Practical: Solution to The HALD Knowledge Graph#
This section has been inspired by the work of Robert Haas on Biomedical Knowledge Graphs which can be found at robert-haas/awesome-biomedical-knowledge-graphs
The source of the data is the webpage on Figshare. This include versions in JSON and CSV. The CSV versions are structured for a particular package which we will not be using, so we will use the json packages which are more general.
First we’ll create a data directory.
import os
Download = False
datadir = "HALD_Dataset"
if not os.path.exists(datadir):
os.mkdir(datadir)
Now we define the list of the files that we want to download. We’ll define a list of tuples, with each tuple representing one of the files that we want to fetch, specifying three things:
The name that we want the file to be called.
The URL from where it will be downloaded.
The MD5 checksum which will allow us to verify the downloaded file’s integrity.
# List of files to download
filelist = [
("Entity_info.json", "https://figshare.com/ndownloader/files/43612509", '1746cde24a1bac0460f1ccf646608cc9'),
("Literature_Info.json", "https://figshare.com/ndownloader/files/43612512", "10b78e8ec30f5b85f2a58d8fe24f056b"),
("Longevity_Biomarkers.json", "https://figshare.com/ndownloader/files/43612497", "0dbd9c3f8474dc3cd744ed38af460d75"),
("Relation_Info.json", "https://figshare.com/ndownloader/files/43612506", "0c1fa199269adc58f64ad4d5b9fd87b9"),
("Aging_Biomarkers.json", "https://figshare.com/ndownloader/files/43612503", "abd0eb6cb7295ae500c5d676b7797324")
]
Now we can download the files. For each file in filelist we will:
Download the file from the URL.
If the download request indicates that the download is unsuccessful, print an error.
If the download is successfull, verify the checksum and if that is correct, write the file to disk in
datadir
import requests
import hashlib
if Download:
for f in filelist:
response = requests.get(f[1])
file_Path = datadir + "/" + f[0]
if response.status_code != 200:
print('Failed to download file {f[0]} from {f[1]}')
else:
m = hashlib.md5()
m.update(response.content)
if m.hexdigest() == f[2]:
print(f"SUCCESS: File {f[0]} downloaded from {f[1]} with correct checksum {f[2]}")
with open(file_Path, 'wb') as file:
file.write(response.content)
else:
print(f"ERROR: File {f[0]} downloaded from {f[1]} with incorrect checksum {m.hexdigest()} (should be {f[2]})")
What does the data look like?#
Let us inspect these files. The two key files here are those containing the entities (nodes) and the edges (relations).
import json
def load_json(fname):
with open(fname, 'rb') as file:
return json.load(file)
nodes = load_json(f"{datadir}/{filelist[0][0]}")
edges = load_json(f"{datadir}/{filelist[3][0]}")
What are these new data structures?
print(type(nodes))
print(type(edges))
<class 'dict'>
<class 'dict'>
How big are they?
print(f"There are {len(nodes)} and {len(edges)} edges")
There are 12257 and 116495 edges
There are several nodes in the dataset which seem somehow upsetting to OWLReady2. We need to remove the nodes and their edges.
edges.keys()
dict_keys(['Pulmonary Disease, Chronic Obstructive-defined-Inflammation', 'Anorexia-associate-Sarcopenia', 'Sarcopenia-associate-Anorexia', 'GPT-recognized-Death', 'GPT-increase-Death', 'Dementia-cope-Vision Disorders', 'Dementia-include-Endotoxemia', 'Death-develop-Aggressive Periodontitis', 'CD8A-expanded-Lung Neoplasms', 'Constipation-associated-Sarcopenia', 'Sarcopenia-associated-Constipation', 'Dementia-commence-Cholesterol', 'Head and Neck Neoplasms-exclude-Melanoma', 'Atrial Fibrillation-coexist with-Hypertension', 'Atrial Fibrillation-multiply-Stroke', 'Atrial Fibrillation-multiply-Death', 'Atrial Fibrillation-coexist-Hypertension', 'Hypertension-multiply-Death', 'Communicable Diseases-infect-Infections', 'HIV Infections-live-Heart Diseases', 'HIV Infections-managed-Chronic Disease', 'Blindness-noted-Uveitis', 'Blindness-noted-Panuveitis', 'Pituitary Neoplasms-considered-Diabetes Mellitus, Type 2', 'Doxorubicin-stratify-Liposarcoma', 'Nervous System Diseases-reduce-Diabetes Mellitus, Type 1', 'Glucose-prevent-Nervous System Diseases', 'Glucose-reduce nerve conduction abnormalities in-Diabetes Mellitus, Type 1', 'Hip Fractures-result-Death', 'Seizures-improve-Hearing Disorders', 'Pneumonia-prophylactic use of-Ascorbic Acid', 'Pneumonia-investigated-Ascorbic Acid', 'Cholecalciferol-decrease-Death', 'alpha-Linolenic Acid-induce-Cerebral Infarction', 'Insulin Glargine-result-INS', 'Colonic Diseases-associated-Infections', 'Infections-associated-Colonic Diseases', 'Dementia-treated-Hip Fractures', 'EPO-delay-Anemia', 'EPO-delay-Kidney Failure, Chronic', 'GHRH-elevate-GGH', 'Obesity-identified-Osteoporosis', 'CD8A-considered-CD4', 'Erectile Dysfunction-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-Erectile Dysfunction', 'Erectile Dysfunction-vary-Diabetes Mellitus', 'Sarcopenia-studied-Scleroderma, Systemic', 'Sarcopenia-studied-Autoimmune Diseases', 'Pain-cope-Ulcer', 'Pain-caused-Neoplasms', 'Pain-caused-Drug-Related Side Effects and Adverse Reactions', 'Lymphoma-treated-Neoplasms', 'Chronic Disease-associated-Death', 'Death-associated-Chronic Disease', 'GPT-associated-Non-alcoholic Fatty Liver Disease', 'Non-alcoholic Fatty Liver Disease-associated-GPT', 'Rupture-include-Infections', 'Dementia-be with-Infections', 'PLP1-exacerbated-Infections', 'Death-underlie-Heart Diseases', 'Nausea-affect-Sleep Wake Disorders', 'Hemorrhage-develop-Hip Fractures', 'Coronary Artery Disease-observed-Pulmonary Disease, Chronic Obstructive', 'Heart Failure-observed-Pulmonary Disease, Chronic Obstructive', 'Heart Failure-increase-Infections', 'Diabetes Mellitus-increase-Infections', 'Kidney Failure, Chronic-increase-Infections', 'Obesity-increase-Infections', 'Colorectal Neoplasms-reported-Neoplasms', 'Fractures, Bone-treated-Wounds and Injuries', 'Obesity-undergo-Glucose', 'Cholesterol-screened-Dementia', 'Chemical and Drug Induced Liver Injury-measured-Congenital Hyperinsulinism', 'CRP-followed-Death', 'Neoplasms-exclude-Neoplasm Metastasis', 'Alzheimer Disease-genotype-C9orf72', 'C9orf72-recruited-Alzheimer Disease', 'C9orf72-genotype-Alzheimer Disease', 'Renal Insufficiency, Chronic-evaluate-Cardiovascular Diseases', 'UMOD-measure-Chronic Kidney Disease-Mineral and Bone Disorder', 'Dyspnea-associated-Death', 'Death-associated-Dyspnea', 'Tachypnea-associated-Death', 'Death-associated-Tachypnea', 'Delirium-associated-Death', 'Death-associated-Delirium', 'Ezetimibe, Simvastatin Drug Combination-compared-Acute Coronary Syndrome', 'Alzheimer Disease-include-Dementia', 'Diabetes Mellitus-increase-Death', 'Diabetes Mellitus-increase-Heart Block', 'Arrhythmias, Cardiac-increase-Death', 'Psychomotor Agitation-associated-Death', 'Death-associated-Psychomotor Agitation', 'Arrhythmias, Cardiac-increase-Heart Block', 'Coma-associated-Death', 'Death-associated-Coma', 'Death-increase-Heart Block', 'Bradycardia-associated-Death', 'Death-associated-Bradycardia', 'Rhabdomyolysis-associated-Death', 'Death-associated-Rhabdomyolysis', 'Hypothermia-associated-Death', 'Death-associated-Hypothermia', 'Cardiovascular Diseases-experience-Myocardial Infarction', 'Fever-associated-Death', 'Death-associated-Fever', 'Cardiovascular Diseases-experience-Coronary Artery Disease', 'Cardiovascular Diseases-experience-Cerebral Infarction', 'Cardiovascular Diseases-experience-Stroke', 'Pneumoperitoneum-require-Hypertension, Pulmonary', 'Pneumoperitoneum-complications-Bronchial Spasm', 'Pneumoperitoneum-require-Bronchial Spasm', 'Erectile Dysfunction-said-Prostatic Neoplasms', 'Erectile Dysfunction-manage-Diabetes Mellitus', 'Prostatic Neoplasms-manage-Diabetes Mellitus', 'Triglycerides-associated-Hypertension', 'Hypertension-associated-Triglycerides', 'Fatty Acids-indicate-Diabetes Mellitus, Type 2', 'Memory Disorders-predict-Dementia', 'Myocardial Infarction-identified-Angina Pectoris', 'Stroke-identified-Angina Pectoris', 'Heart Failure-identified-Angina Pectoris', 'Fatigue-base-Parkinson Disease', 'Parkinsonian Disorders-base-Parkinson Disease', 'Arterial Occlusive Diseases-identified-Angina Pectoris', 'Phosphatidylcholines-contain-Fatty Acids, Monounsaturated', 'Pain-seem-Joint Diseases', 'Dementia-increase-Cerebrovascular Disorders', 'Ceramides-reduce-SLC2A4', 'Ceramides-reduce-AKT1', 'Ceramides-reduce-Glucose', 'Seizures-include-Adenomatous Polyposis Coli', 'Seizures-include-Hypereosinophilic Syndrome', 'Plaque, Amyloid-Establish-Alzheimer Disease', 'Hypertension-associated-Low Back Pain', 'Low Back Pain-associated-Hypertension', 'CISD3-share-CISD2', 'Alzheimer Disease-phosphorylated-LYN', 'Heart Diseases-associated-Low Back Pain', 'Low Back Pain-associated-Heart Diseases', 'Cerebrovascular Disorders-associated-Low Back Pain', 'Low Back Pain-associated-Cerebrovascular Disorders', 'Hypertension-correlated-Death', 'Respiratory Tract Infections-present-Death', 'Neoplasms-include-Death', 'Immunologic Deficiency Syndromes-lead-Meibomian Gland Dysfunction', 'Skin Neoplasms-include-Death', 'Immunologic Deficiency Syndromes-lead-Dry Eye Syndromes', "Sjogren's Syndrome-lead-Meibomian Gland Dysfunction", 'Androgen-Insensitivity Syndrome-lead-Meibomian Gland Dysfunction', 'Alzheimer Disease-develop-Dementia, Vascular', 'Alzheimer Disease-develop-Dementia', 'Obesity-associated-Death', 'Death-associated-Obesity', 'Alzheimer Disease-differentiate-Dementia', 'Alzheimer Disease-predict-Dementia', 'Carcinoma, Hepatocellular-disrupt-FOXA1', 'NOX1-activated-Infliximab', 'NOX4-activated-Infliximab', 'Infliximab-activated-NOX5', 'Ceramides-observed-Pulmonary Alveolar Proteinosis', 'Death-raise-Arrhythmias, Cardiac', 'Death-reduce-Heart Diseases', 'Death-raise-Coronary Artery Disease', 'Arrhythmias, Cardiac-associated-Death, Sudden', 'Death, Sudden-associated-Arrhythmias, Cardiac', 'Heart Diseases-associated-Death, Sudden', 'Death, Sudden-associated-Heart Diseases', 'Coronary Artery Disease-associated-Death, Sudden', 'Death, Sudden-associated-Coronary Artery Disease', 'Coronary Artery Disease-tolerated-Aortic Valve Insufficiency', 'Death, Sudden-tolerated-Aortic Valve Insufficiency', 'Hyperpigmentation-develop-Erythema', 'CD4-associated-CD8A', 'CD8A-associated-CD4', 'Ceramides-down-regulated-Neoplasms', 'Inflammation-show-Infections', 'Mitochondrial Diseases-caused-Genetic Diseases, Inborn', 'Polycystic Ovary Syndrome-used-AMH', 'LCAT-transfer-Lecithins', 'Cholesterol-increase-LCAT', 'GH1-determine-FSHR', 'GH1-determine-LHCGR', 'GH1-determine-BMPR1B', 'L1CAM-induced-CDKN2A', 'GH1-determine-GHR', 'L1CAM-induced-TGFA', 'L1CAM-induced-SLC25A6', 'TGFA-induced-SLC25A6', 'S100A8-associated-Neoplasms', 'Neoplasms-associated-S100A8', 'S100A9-associated-Neoplasms', 'Neoplasms-associated-S100A9', 'HIV Infections-assess-Respiratory Tract Infections', 'Neoplasms-categorized-Vascular Neoplasms', 'Stroke-associated-Death', 'Death-associated-Stroke', 'MIR22-identify-HDAC4', 'MIR22-identify-RCOR1', 'MIR22-identify-RGS2', 'NFE2L2-stabilized-NQO1', 'Oleic Acid-comprise-Fatty Acids', 'NFE2L2-stabilized-GCLM', 'Metabolic Syndrome-defined-Hypertension', 'Metabolic Syndrome-defined-Diabetes Mellitus', 'Metabolic Syndrome-defined-Dyslipidemias', 'Metabolic Syndrome-defined-Glucose', 'Metabolic Syndrome-defined-Triglycerides', 'Metabolic Syndrome-defined-Cholesterol', 'Hypertension-associated-Albuminuria', 'Albuminuria-associated-Hypertension', 'Diabetes Mellitus-associated-Albuminuria', 'Albuminuria-associated-Diabetes Mellitus', 'Pancreatitis, Acute Necrotizing-identify-Death', 'Hypotension, Orthostatic-associated-Malnutrition', 'Malnutrition-associated-Hypotension, Orthostatic', 'Heart Failure-detected-Pulmonary Disease, Chronic Obstructive', 'Hypertension-found-Infections', 'Diabetes Mellitus-found-Infections', 'Heart Failure-found-Infections', 'PKD1-lead-Kidney Diseases', 'PKD2-lead-Kidney Diseases', 'Endocarditis-contribute out-Death', 'Osteoporotic Fractures-increase-Venous Thromboembolism', 'Atrial Fibrillation-increase-Venous Thromboembolism', 'Neoplasms-associated-Death', 'Death-associated-Neoplasms', 'Hypertension-associated-Atrial Fibrillation', 'Atrial Fibrillation-associated-Hypertension', 'Pancreatitis, Acute Necrotizing-classified-Necrosis', 'Renal Insufficiency-associated-Death', 'Death-associated-Renal Insufficiency', 'Cough-associated-Death', 'Death-associated-Cough', 'NR1H3-contribute-FOXA1', 'Anorexia-associated-Death', 'Death-associated-Anorexia', 'NR1H3-associated-INS', 'INS-associated-NR1H3', 'FOXA1-associated-INS', 'INS-associated-FOXA1', 'Pain-associated-Sarcopenia', 'Sarcopenia-associated-Pain', 'Diabetes Mellitus-treated-Glucose', 'FMR1-determined-Primary Ovarian Insufficiency', 'Infertility, Female-undergo-Ovarian Diseases', 'Pericardial Effusion-raise-Thromboembolism', 'Phosphatidylcholines-contain-Phosphatidylethanolamines', 'Phosphatidylcholines-contain-Fatty Acids, Unsaturated', 'Neoplasm Invasiveness-show-Neoplasm Metastasis', 'Osteoporosis-defined-Fractures, Bone', 'Vertigo-Most patients with-Benign Paroxysmal Positional Vertigo', 'Vertigo-notice-Benign Paroxysmal Positional Vertigo', 'Coronary Artery Disease-matched-Abnormalities, Drug-Induced', 'Phosphatidylcholines-associated-Glucose', 'Glucose-associated-Phosphatidylcholines', 'Lung Neoplasms-reduce-Death', 'CD4-reduce-Lung Neoplasms', 'CD4-reduce-Death', 'Pain-base-Myalgia', 'Myalgia-base-Pain', 'Obesity-linked-Alzheimer Disease', 'Heparin-protect-Venous Thrombosis', 'Fractures, Bone-increase-Obesity', 'Fractures, Bone-develop-Bone Diseases, Metabolic', 'Fractures, Stress-increase-Obesity', 'Fractures, Stress-develop-Bone Diseases, Metabolic', 'Obesity-develop-Bone Diseases, Metabolic', 'Osteochondritis-localize-Osteoporotic Fractures', 'Osteochondritis-develop-Bone Diseases, Metabolic', 'Osteochondrodysplasias-develop-Bone Diseases, Metabolic', 'Osteoporotic Fractures-develop-Bone Diseases, Metabolic', 'Chronic Disease-associated-Hypertension', 'Hypertension-associated-Chronic Disease', 'Neurotoxicity Syndromes-reveal-Alzheimer Disease', 'Chronic Disease-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-Chronic Disease', 'Chronic Disease-associated-Respiratory Tract Diseases', 'Respiratory Tract Diseases-associated-Chronic Disease', 'VWF-Rise-Ristocetin', 'Delirium-precede-Death', 'Delirium-exclude-Death', 'SIRT1-induce-Heart Arrest', 'Dementia-precede-Death', 'Dementia-exclude-Death', 'FOXO3-induce-Heart Arrest', 'CHARGE Syndrome-provided-Cardiovascular Diseases', 'Tauopathies-propose-Dementia', 'Tauopathies-propose-Alzheimer Disease', 'Dementia-propose-Alzheimer Disease', 'Werner Syndrome-compare-Inflammation', 'Werner Syndrome-examined-FASLG', 'Alzheimer Disease-see-Headache Disorders, Secondary', 'FASLG-compare-Inflammation', 'Dyspnea-identified-Hip Fractures', 'Nervous System Diseases-prove-Death', 'Cardiovascular Abnormalities-decrease-Ventricular Premature Complexes', 'Spondylitis, Ankylosing-prove-Death', 'Cerebral Infarction-predict-Hypertension', 'Coronary Artery Disease-stratified-FNDC5', 'Cerebral Infarction-controlled-Hypertension', 'Ceramides-associated-Alzheimer Disease', 'Alzheimer Disease-associated-Ceramides', 'Headache-codified-Migraine Disorders', 'Diabetes Mellitus-include-Cardiovascular Diseases', 'CD4-include-Cardiovascular Diseases', 'Cholesterol-include-Cardiovascular Diseases', 'Drug-Related Side Effects and Adverse Reactions-induced-Ascorbic Acid', 'Atrial Fibrillation-associated-Coronary Artery Disease', 'Coronary Artery Disease-associated-Atrial Fibrillation', 'Atrial Fibrillation-associated-Cerebrovascular Disorders', 'Cerebrovascular Disorders-associated-Atrial Fibrillation', 'Diabetes Mellitus-undergo-Cataract', 'Infections-include-Hemolytic-Uremic Syndrome', 'Infections-include-Purpura, Thrombotic Thrombocytopenic', 'Ceramides-associated-Dementia', 'Dementia-associated-Ceramides', 'Renal Insufficiency, Chronic-increase-Diabetes Mellitus', 'Renal Insufficiency, Chronic-increase-Myotonic Dystrophy', 'Death-related-Epilepsy', 'Cholesterol-account-Atherosclerosis', 'rs1805124-associated-rs7626962', 'rs7626962-associated-rs1805124', 'Death-caused-Fever', 'Death-caused-Pulmonary Edema', 'Drug-Related Side Effects and Adverse Reactions-occur-Neutropenia', 'APOE-include-BDNF', 'APOE-include-MAOA', 'BDNF-include-MAOA', 'Drug-Related Side Effects and Adverse Reactions-consist-Vomiting', 'Drug-Related Side Effects and Adverse Reactions-consist-Bone Marrow Diseases', 'Drug-Related Side Effects and Adverse Reactions-consist-Leukopenia', 'Sarcopenia-measured-Ataxia', 'Drug-Related Side Effects and Adverse Reactions-consist-Anemia', 'Drug-Related Side Effects and Adverse Reactions-consist-Thrombocytopenia', 'Dementia-stem-Memory Disorders', 'Drug-Related Side Effects and Adverse Reactions-consist-Kidney Diseases', 'Drug-Related Side Effects and Adverse Reactions-consist-Neurotoxicity Syndromes', 'Stroke-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-Stroke', 'Stroke-associated-Hypertension', 'Hypertension-associated-Stroke', 'TFRC-stearoylate-MAPK8', 'Death-estimate-Respiratory Tract Diseases', 'Death-estimate-Cardiovascular Diseases', 'Lymphoma, Non-Hodgkin-contain-Anthracyclines', 'Colonic Neoplasms-correlate-Neoplasms', 'Triglycerides-be in-Prostatic Hyperplasia', 'Triglycerides-be in-Metabolic Syndrome', 'Triglycerides-notice-Metabolic Syndrome', 'Respiratory Distress Syndrome-associated-Death', 'Death-associated-Respiratory Distress Syndrome', 'Thrombocytopenia-associated-Death', 'Death-associated-Thrombocytopenia', 'Diabetes Mellitus-associated-Hypertension', 'Hypertension-associated-Diabetes Mellitus', 'Cardiac Output, Low-decrease-HEBP1', 'CRP-associated-Hypertension', 'Hypertension-associated-CRP', 'PDGFRB-diagnose-Parkinson Disease', 'FOS-diagnose-Parkinson Disease', 'Calcinosis-associated-Osteosarcoma', 'Osteosarcoma-associated-Calcinosis', 'Calcinosis-correlated-Osteosarcoma', 'IGFBP3-diagnose-Parkinson Disease', 'Calcinosis-correlated-SIRT7', 'Infliximab-followed-Inflammatory Bowel Diseases', 'Calcinosis-associated-RUNX2', 'RUNX2-associated-Calcinosis', 'Calcinosis-correlated-RUNX2', 'Alzheimer Disease-reflect-VEGFA', 'Aneurysm-reflect-VEGFA', 'VEGFA-reflect-Alzheimer Disease', 'Adalimumab-followed-Inflammatory Bowel Diseases', 'VEGFA-reflect-Aneurysm', 'KL-associated-Triglycerides', 'Triglycerides-associated-KL', 'Ustekinumab-followed-Inflammatory Bowel Diseases', 'KL-associated-Cholesterol', 'Cholesterol-associated-KL', 'KL-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-KL', 'Autoimmune Diseases of the Nervous System-include-Autoimmune Diseases', 'INS-involve-Hyperglycemia', 'Rituximab-used-Autoimmune Diseases', 'Rituximab-used-Autoimmune Diseases of the Nervous System', 'Cerebral Infarction-activate-NFE2L2', 'Glycogen Storage Disease Type II-activate-NFE2L2', 'Atrophy-associated-Choroidal Neovascularization', 'Choroidal Neovascularization-associated-Atrophy', 'Atrophy-associated-Anophthalmos', 'Anophthalmos-associated-Atrophy', 'Atrophy-evaluate-Anophthalmos', 'Atrophy-associated-VEGFA', 'VEGFA-associated-Atrophy', 'FGF23-play-Renal Insufficiency, Chronic', 'FGF23-play-Cardiovascular Diseases', 'Fasciculation-associate-Myalgia', 'Myalgia-associate-Fasciculation', 'Fasciculation-associate-Edema', 'Edema-associate-Fasciculation', 'Fasciculation-associate-MB', 'MB-associate-Fasciculation', 'Periodontitis-develop-Cardiomyopathies', 'Tooth Loss-develop-Cardiomyopathies', 'ALPL-exhibit-Periodontitis', 'ALPL-exhibit-Tooth Loss', 'ALPL-develop-Cardiomyopathies', 'CD8A-associated-Arbovirus Infections', 'Arbovirus Infections-associated-CD8A', 'CD8A-associated-Autoimmune Diseases', 'Autoimmune Diseases-associated-CD8A', 'CD8A-associated-Neoplasms', 'Neoplasms-associated-CD8A', 'BACE1-measured-Cardiovascular Diseases', 'BACE1-measured-Coronary Artery Disease', 'BACE1-measured-Acute Coronary Syndrome', 'INS-alleviate-Dyslipidemias', 'INS-reduce-Inflammation', 'Glioblastoma-sent-Brain Neoplasms', 'Porphyrias-confer-Carcinoma, Hepatocellular', 'Porphyrias-caused-HMBS', 'MGMT-sent-Brain Neoplasms', 'USP17L2-used-SIRT7', 'CD8A-restrict-GZMB', 'GZMB-assessed-SELL', 'GZMB-assessed-B3GAT1', 'GZMB-assessed-CD8A', 'Death-burdened-Cardiovascular Diseases', 'Metabolic Syndrome-characterized-Metabolic Diseases', 'Acute Kidney Injury-associated-Death', 'Death-associated-Acute Kidney Injury', 'Sepsis-associated-Death', 'Death-associated-Sepsis', 'Obesity-exist-Death', 'Obesity-presented-Death', 'Euthyroid Sick Syndromes-related-Fractures, Bone', 'Euthyroid Sick Syndromes-related-Wounds and Injuries', 'Cerebral Hemorrhage-treated-Wounds and Injuries', 'Pneumonia-detect-Lung Diseases', 'Lung Neoplasms-detect-Neoplasms', 'Osteoporosis-lead-Fractures, Bone', 'HIV Infections-control-Death', 'Acquired Immunodeficiency Syndrome-control-Death', 'Infections-increase-Death', 'Diabetes Mellitus-lead-Obesity', 'Angina Pectoris-occur-Myocardial Infarction', 'Pain-improve-Movement Disorders', 'Tuberculosis-remain-Death', 'Tuberculosis-remain-Communicable Diseases', 'Death-associated-Heredodegenerative Disorders, Nervous System', 'Heredodegenerative Disorders, Nervous System-associated-Death', 'Chronic Disease-contribute-Death', 'Aneurysm-experience-Headache Disorders, Secondary', 'Aneurysm-associated-Headache Disorders, Secondary', 'Headache Disorders, Secondary-associated-Aneurysm', 'Neoplasms-collected-Communicable Diseases', 'Cardiovascular Diseases-emerging-Death', 'Cardiovascular Diseases-attributed-Dyslipidemias', 'Delirium-used-Basal Ganglia Diseases', 'Delirium-used-Cardiovascular Diseases', 'Eyelid Diseases-lead-Eye Diseases', 'Renal Insufficiency, Chronic-categorized-Kidney Diseases', 'Death-include-Pulmonary Disease, Chronic Obstructive', 'Osteoarthritis-result-Muscle Weakness', 'Osteoporosis-associated-Death', 'Death-associated-Osteoporosis', 'Diabetes Mellitus, Type 2-associated-Sarcopenia', 'Sarcopenia-associated-Diabetes Mellitus, Type 2', 'Neoplasms-result-Death', 'Neoplasms-used-Osteosarcoma', 'HIV Infections-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-HIV Infections', 'Stroke-include-Death', 'Dementia-avoided-Hypertension', 'Dementia-treat-Hypertension', 'Dementia-avoided-Diabetes Mellitus', 'Dementia-treat-Diabetes Mellitus', 'Stroke-include-Cerebral Infarction', 'Stroke-occur-Cerebral Infarction', 'Death-include-Cerebral Infarction', 'Death-occur-Cerebral Infarction', 'Diabetes Mellitus-associated-Atherosclerosis', 'Atherosclerosis-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-Diabetes Mellitus', 'Diabetes Mellitus-result-Cardiovascular Diseases', 'Diabetes Mellitus-associated-Death', 'Death-associated-Diabetes Mellitus', 'Atherosclerosis-result-Cardiovascular Diseases', 'Atherosclerosis-result-Death', 'Abnormalities, Drug-Induced-include-Parkinson Disease', 'Obesity-accompany-Sarcopenia', 'Tuberculosis-cause-Death', 'Hip Fractures-become-Death', 'Hip Fractures-associated-Death', 'Death-associated-Hip Fractures', 'Communicable Diseases-cause-Death', 'Alzheimer Disease-diagnosed-Memory Disorders', 'Acromegaly-include-Adenoma', 'Nervous System Diseases-contribute-Blood Coagulation Disorders', 'Osteoporotic Fractures-decrease-Wounds and Injuries', 'Diabetes Mellitus-contribute-Blood Coagulation Disorders', 'Liver Failure-manage-Carcinoma, Hepatocellular', 'Blood Coagulation Disorders-result-Coronary Artery Disease', 'Blood Coagulation Disorders-contribute-Nervous System Diseases', 'Sarcopenia-live-HIV Infections', 'Craniocerebral Trauma-associated-Death', 'Death-associated-Craniocerebral Trauma', 'Inflammatory Bowel Diseases-use-Death', 'Death-estimate-Neoplasms', 'Dementia-estimate-Neoplasms', 'Colitis, Ulcerative-include-Inflammatory Bowel Diseases', 'Hypotension-associated-Cardiomyopathies', 'Cardiomyopathies-associated-Hypotension', 'Hypotension-associated-Death', 'Death-associated-Hypotension', 'Cardiomyopathies-associated-Death', 'Death-associated-Cardiomyopathies', 'Dyslipidemias-associated-Death', 'Death-associated-Dyslipidemias', 'Heart Diseases-associated-Death', 'Death-associated-Heart Diseases', 'Dyslipidemias-increase-Death', 'Hypotension-undergo-Hip Fractures', 'Chronic Disease-associated-Malnutrition', 'Malnutrition-associated-Chronic Disease', 'Diabetes Mellitus-associated-Malnutrition', 'Malnutrition-associated-Diabetes Mellitus', 'Cardiovascular Diseases-associated-Malnutrition', 'Malnutrition-associated-Cardiovascular Diseases', 'Dementia-diagnosed-Alzheimer Disease', 'Intermittent Claudication-cause-Pain', 'Cerebral Infarction-enrol-Stroke', 'Cerebral Infarction-aged-Stroke', 'Pulmonary Embolism-include-Venous Thromboembolism', 'Venous Thrombosis-include-Venous Thromboembolism', 'Coronavirus Infections-include-Venous Thromboembolism', 'Myelodysplastic Syndromes-characterized-Hematologic Diseases', 'Aortic Valve Stenosis-associated-Death', 'Death-associated-Aortic Valve Stenosis', 'Myelodysplastic Syndromes-characterized-Dysplastic Nevus Syndrome', 'Myelodysplastic Syndromes-characterized-Genetic Diseases, Inborn', 'Hyperthyroidism-associated-Hypotrichosis', 'Hypotrichosis-associated-Hyperthyroidism', 'Hyperthyroidism-known-Hypotrichosis', 'Diabetes Mellitus-surveyed-Signs and Symptoms, Digestive', 'Prediabetic State-surveyed-Signs and Symptoms, Digestive', 'Prediabetic State-use-Diabetes Mellitus', 'Signs and Symptoms, Digestive-use-Diabetes Mellitus', 'Death-related-Wounds and Injuries', 'Signs and Symptoms, Digestive-occur-Diabetes Mellitus', 'Malocclusion-code-Death', 'Death-code-Pneumonia', 'Chronic Pain-vary-Pain', 'Chronic Pain-base-Pain', 'Pelvic Neoplasms-increase-Death', 'Death-influence-Atrial Fibrillation', 'Death-increase-Pelvic Neoplasms', 'Alzheimer Disease-play-Neurogenic Inflammation', 'Cerebral Arterial Diseases-consider-Cerebral Small Vessel Diseases', 'Stroke, Lacunar-consider-Cerebral Small Vessel Diseases', 'Edema-remit-Synovitis', 'Renal Insufficiency-increase-Death', 'Hip Fractures-treat-Wounds and Injuries', 'Heart Failure-face-Death', 'Sleep Wake Disorders-associated-Hypertension', 'Hypertension-associated-Sleep Wake Disorders', 'Hip Fractures-include-Fractures, Bone', 'Fractures, Bone-occur-Femoral Neck Fractures', 'Hip Fractures-occur-Femoral Neck Fractures', 'Frailty-occur-Diabetes Mellitus', 'Atherosclerosis-inhibit-Inflammation', 'Neoplasms-associated-Drug-Related Side Effects and Adverse Reactions', 'Drug-Related Side Effects and Adverse Reactions-associated-Neoplasms', 'Pain-put-Death', 'Atrial Fibrillation-associate-Death', 'Death-associate-Atrial Fibrillation', 'Infarction, Middle Cerebral Artery-lead-Hypotension', 'Hypertension-known-Chronic Disease', 'Neutropenia-cause-Pain', 'Neutropenia-aggravate-Thrombocytopenia', 'Neutropenia-cause-Anemia', 'Neutropenia-cause-Myelodysplastic Syndromes', 'Neutropenia-cause-Leukemia, Myeloid, Acute', 'Pain-aggravate-Thrombocytopenia', 'Pain-cause-Anemia', 'Pain-cause-Myelodysplastic Syndromes', 'Sarcopenia-associated-Drug-Related Side Effects and Adverse Reactions', 'Drug-Related Side Effects and Adverse Reactions-associated-Sarcopenia', 'Pain-cause-Leukemia, Myeloid, Acute', 'Thrombocytopenia-cause-Myelodysplastic Syndromes', 'Anemia-cause-Myelodysplastic Syndromes', 'HIV Infections-experience-Pain', 'Pain-link-Inflammation', 'Infections-associated-Venous Thromboembolism', 'Venous Thromboembolism-associated-Infections', 'Venous Thromboembolism-include-Infections', 'Venous Thromboembolism-occur-Infections', 'Death-observed-Breast Neoplasms, Male', 'Obesity-seem-Renal Insufficiency, Chronic', 'Atherosclerosis-lead-Myocardial Infarction', 'Obesity, Abdominal-seem-Renal Insufficiency, Chronic', 'Death-observed-Heart Failure', 'Atherosclerosis-lead-Death', 'Breast Neoplasms, Male-observed-Death', 'Cardiovascular Diseases-lead-Myocardial Infarction', 'Cardiovascular Diseases-lead-Death', 'Arbovirus Infections-result-Death', 'Chronic Disease-associated-Infections', 'Infections-associated-Chronic Disease', 'Diabetes Mellitus-characterized-Hyperglycemia', 'Metabolic Diseases-characterized-Hyperglycemia', 'Pain-presented-Ankle Injuries', 'Gait Disorders, Neurologic-known-Sarcopenia', 'Cerebral Infarction-tend-Death', 'Death-suggest-Blood Coagulation Disorders', 'Wounds and Injuries-involve-Inflammation', 'Osteoporosis-occur-Carotid Artery Diseases', 'Wounds and Injuries-involve-Blood Coagulation Disorders', 'Osteoporosis-cause-Calcinosis', 'Carotid Artery Diseases-cause-Calcinosis', 'Bone Diseases, Metabolic-coincide-Inflammation', 'Bone Diseases, Metabolic-coincide-Osteoporosis', 'Death-continue-Stroke', 'Bone Diseases, Metabolic-coincide-Fractures, Bone', 'Stroke-represent-Cardiovascular Diseases', 'Inflammation-coincide-Osteoporosis', 'Inflammation-increase-Osteoporosis', 'Inflammation-coincide-Fractures, Bone', 'Fatigue-related-Neoplasms', 'Cardiovascular Diseases-drive-Pneumonia', 'Seizures-associated-Death', 'Death-associated-Seizures', 'Sensation Disorders-hear-Vision Disorders', 'Scoliosis-compare-Osteoporotic Fractures', 'Ocular Hypertension-develop-Cataract', 'Postoperative Complications-undergo-Hip Fractures', 'Fractures, Bone-lead-Death', 'Stroke-associated-Aphasia', 'Aphasia-associated-Stroke', 'Osteoporosis-publish-Fractures, Bone', 'Osteoporosis-develop-Fractures, Bone', 'Sleepiness-associated-Coronary Artery Disease', 'Coronary Artery Disease-associated-Sleepiness', 'Blood Coagulation Disorders-suffer-Headache Disorders, Secondary', 'Sleepiness-associated-Brain Infarction', 'Brain Infarction-associated-Sleepiness', 'Infections-exacerbate-Malnutrition', 'Hemostatic Disorders-exacerbate-Malnutrition', 'Fatigue-defined-Vision Disorders', 'Death-admitted-Cardiac Complexes, Premature', 'Tuberculosis, Pulmonary-used-Adenomatous Polyposis Coli', 'Tuberculosis-used-Adenomatous Polyposis Coli', 'Tibial Neuropathy-used-Osteoarthritis', 'Osteoporosis-put-Fractures, Bone', 'Bone Diseases, Metabolic-put-Fractures, Bone', 'Atrial Fibrillation-associated-Thromboembolism', 'Thromboembolism-associated-Atrial Fibrillation', 'Atrial Fibrillation-confer-Cerebral Infarction', 'Atrial Fibrillation-confer-Ischemia', 'Subarachnoid Hemorrhage-associated-Death', 'Death-associated-Subarachnoid Hemorrhage', 'Death-related-Neoplasms', 'Inflammation-play-Intracranial Arteriosclerosis', 'Death-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-Death', 'Creutzfeldt-Jakob Syndrome-associated-Brain Diseases', 'Brain Diseases-associated-Creutzfeldt-Jakob Syndrome', 'Death-associated-Hypertension', 'Hypertension-associated-Death', 'Cardiac Output, Low-fall-Myoclonic Epilepsies, Progressive', 'Sarcopenia-associated-Carcinoma, Hepatocellular', 'Carcinoma, Hepatocellular-associated-Sarcopenia', 'Muscular Diseases-use-Myositis', 'HIV Infections-diagnosed-Neoplasms', 'Cerebral Small Vessel Diseases-associated-Stroke', 'Stroke-associated-Cerebral Small Vessel Diseases', 'Sarcopenia-associated-Fractures, Bone', 'Fractures, Bone-associated-Sarcopenia', 'Death-occur-Hypertension', 'Death-occur-Diabetes Mellitus', 'Hypertension-reflect-Metabolic Diseases', 'Heart Block-undergo-Stomach Neoplasms', 'Hypertension-reflect-Genetic Diseases, Inborn', 'Metabolic Diseases-reflect-Genetic Diseases, Inborn', 'Death-increase-Hemorrhage', 'Death-increase-Stroke', 'Cerebral Hemorrhage-caused-Cerebral Small Vessel Diseases', 'Cerebral Hemorrhage-caused-Hypertension', 'Cerebral Hemorrhage-caused-Arteriolosclerosis', 'Carpal Tunnel Syndrome-develop-Fractures, Bone', 'Lymphoma, B-Cell-minimize-Drug-Related Side Effects and Adverse Reactions', 'Hip Fractures-increase-Death', 'Chronic Disease-cause-Headache Disorders, Secondary', 'Hemorrhage-increase-Stroke', 'Infections-refer-Diabetic Foot', 'Diabetic Foot-refer-Diabetes Mellitus', 'Diabetic Foot-caused-Diabetes Mellitus', 'Infections-caused-Diabetes Mellitus', 'Nervous System Diseases-caused-Diabetes Mellitus', 'Diabetes Mellitus-identify-Myotonic Dystrophy', 'Dementia-develop-Thyroid Diseases', 'Hypothyroidism-associated-Dementia', 'Dementia-associated-Hypothyroidism', 'Hypothyroidism-diagnosed-Dementia', 'Adenomatous Polyposis Coli-avoid-Osteoporosis', 'Pain-live-Dementia', 'Neurodegenerative Diseases-present-Movement Disorders', 'Hepatitis B-put-Hepatitis, Viral, Human', 'Hepatitis B-correspond-Infections', 'Sarcopenia-associated-Neoplasms', 'Neoplasms-associated-Sarcopenia', 'Pulmonary Disease, Chronic Obstructive-carry-Death', 'Genetic Diseases, Inborn-associated-Dementia', 'Dementia-associated-Genetic Diseases, Inborn', 'Tuberculosis, Pulmonary-follow-Tuberculosis', 'Vascular System Injuries-increase-Diabetes Mellitus', 'Hypotension-associated-Syncope', 'Syncope-associated-Hypotension', 'Death-follow-Stroke', 'Infections-occur-Diabetes Mellitus', 'Death-computed-Anemia', 'Tooth Loss-monitored-Hypertension', 'Psychomotor Agitation-improve-Dementia', 'Acquired Immunodeficiency Syndrome-use-Chronic Disease', 'Acquired Immunodeficiency Syndrome-determine-Chronic Disease', 'Diabetes Mellitus-receive-Diabetic Foot', 'Diabetes Mellitus-complicated-Kidney Failure, Chronic', 'Neoplasms-decrease-Death', 'Osteoarthritis-work-Pain', 'Inflammation-associated-Neoplasms', 'Neoplasms-associated-Inflammation', 'Inflammation-associated-Death', 'Death-associated-Inflammation', 'Delirium-increase-Death', 'Spinal Dysraphism-reviewed-Wounds and Injuries', 'Aortic Aneurysm, Thoracic-undergo-Glycogen Storage Disease Type III', 'Aortic Aneurysm, Thoracic-followed-Aortic Aneurysm', 'Glycogen Storage Disease Type III-followed-Aortic Aneurysm', 'Tibial Meniscus Injuries-incorporate-Neural Tube Defects', 'Sarcopenia-seem-Osteoporosis', 'Diabetes Mellitus-identified-Cardiovascular Diseases', 'Hypertension-identified-Cardiovascular Diseases', 'Hyperlipidemias-identified-Cardiovascular Diseases', 'Ischemia-threatening-Death', 'Osteoporotic Fractures-considered-Neurologic Manifestations', 'Osteoporotic Fractures-considered-Kyphosis', 'Fatigue-experience-Infections', 'Cardiac Output, Low-fall-Diabetic Neuropathies', 'Astigmatism-shift-Cataract', 'Delirium-superimposed-Dementia', 'Atrial Fibrillation-observe-Stroke', 'Aortic Aneurysm, Abdominal-decrease-Death', 'Inflammation-observed-Respiratory Tract Infections', 'Obesity-associated-Back Pain', 'Back Pain-associated-Obesity', 'Diabetes Mellitus-observed-Respiratory Tract Infections', 'Obesity-observed-Respiratory Tract Infections', 'Asthma-observed-Respiratory Tract Infections', 'Pulmonary Disease, Chronic Obstructive-observed-Respiratory Tract Infections', 'Renal Insufficiency, Chronic-observed-Respiratory Tract Infections', 'Hypertension-observed-Respiratory Tract Infections', 'Cancer Pain-collected-Pain', 'HIV Infections-contribute-Cardiovascular Diseases', 'HIV Infections-contribute-Death', 'HIV Infections-associated-Inflammation', 'Inflammation-associated-HIV Infections', 'HIV Infections-lead-Inflammation', 'Appendicitis-assessed-Hemorrhagic Fever with Renal Syndrome', 'HIV Infections-associated-Chronobiology Disorders', 'Chronobiology Disorders-associated-HIV Infections', 'HIV Infections-lead-Chronobiology Disorders', 'Leprosy-present-Dysgeusia', 'Leprosy-caused-Infections', 'Dysgeusia-caused-Infections', 'Neural Tube Defects-identified-Dementia', 'Neural Tube Defects-include-Dementia', 'MIR942-associated-ROCK2', 'ROCK2-associated-MIR942', 'CAT-decrease-Glutathione', 'INS-improve-Glucose', 'SIRT7-involve-Glucose', 'BDNF-moderate-Hypertension', 'Glucose-involve-Calcinosis', 'Glucose-drive-Calcinosis', 'FKBP5-associated-HIV Infections', 'HIV Infections-associated-FKBP5', 'Adenocarcinoma of Lung-comprise-ERBB2', 'INSL3-assessed-Hypogonadism', 'Inflammation-contribute-INS', 'FGF23-measured-Chronic Kidney Disease-Mineral and Bone Disorder', 'GBA-associated-Parkinson Disease', 'Parkinson Disease-associated-GBA', 'PDGFB-mistaken-Hyperparathyroidism', 'ALPL-display-Tooth Loss', 'TNFRSF4-identified-Neoplasms', 'CRP-contribute-Obesity', 'Cardiovascular Diseases-receive-P2RY12', 'CD38-promote-Fibrosis', 'TNFSF15-identified-Neoplasms', 'INS-associated-Sarcopenia', 'Sarcopenia-associated-INS', 'INS-correlate-Cardiovascular Diseases', 'INS-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-INS', 'HMBS-identify-Neoplasms', 'Hip Fractures-compare-Tramadol', 'Metabolic Syndrome-diagnosed-Cholesterol', 'Fractures, Bone-act-HDAC2', 'Hyperinsulinism-expose-TP53', 'Diabetes Mellitus-found-Pancreatic Neoplasms', 'Diabetes Mellitus-utilize-GCG', 'Pancreatic Neoplasms-utilize-GCG', 'CD4-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-CD4', 'Diabetes Mellitus-utilize-INS', 'SIRT1-induced-Obesity', 'Pancreatic Neoplasms-utilize-INS', 'Arthritis, Rheumatoid-got-Rituximab', 'VEGFA-present-Alzheimer Disease', 'Lipopolysaccharides-provide-Syncope, Vasovagal', 'AR-mediate-KLK3', 'RETN-associated-INS', 'INS-associated-RETN', 'KLK3-mediate-Prostatic Neoplasms', 'Inflammation-exert-Hypertrophy', 'ADARB2-associated-ADIPOQ', 'ADIPOQ-associated-ADARB2', 'RETN-associated-Inflammation', 'Inflammation-associated-RETN', 'ADARB2-associated-Triglycerides', 'Triglycerides-associated-ADARB2', 'RETN-exert-Hypertrophy', 'rs2805533-associated-ADIPOQ', 'ADIPOQ-associated-rs2805533', 'rs2805533-associated-Triglycerides', 'Triglycerides-associated-rs2805533', 'HIV Infections-associated-Eicosanoids', 'Eicosanoids-associated-HIV Infections', 'Nijmegen Breakage Syndrome-lead-Lymphoma', 'CDX2-related-Death', 'CDX2-related-Osteoporotic Fractures', 'QRSL1-related-Death', 'QRSL1-related-Osteoporotic Fractures', 'NEFL-associated-Neurodegenerative Diseases', 'Neurodegenerative Diseases-associated-NEFL', 'KL-correlate-GH1', 'KL-correlate-Neoplasms', 'FOXO1-associated-Coronary Artery Disease', 'Coronary Artery Disease-associated-FOXO1', 'FOXO3-associated-Coronary Artery Disease', 'Coronary Artery Disease-associated-FOXO3', 'Carcinoma, Non-Small-Cell Lung-harbour-EGFR', 'Inflammation-elevated-Chronic Disease', 'Inflammation-known-Chronic Disease', 'Carcinoma, Non-Small-Cell Lung-harbour-ALK', 'Inflammation-elevated-Pulmonary Disease, Chronic Obstructive', 'Inflammation-known-Pulmonary Disease, Chronic Obstructive', 'Inflammation-indicate-Pulmonary Disease, Chronic Obstructive', 'Pulmonary Disease, Chronic Obstructive-include-Chronic Disease', 'INS-related-Dementia', 'INS-related-Metabolic Diseases', 'INS-related-Neoplasms', 'IL6-associated-Death', 'Death-associated-IL6', 'CRP-associated-Death', 'Death-associated-CRP', 'Immunologic Deficiency Syndromes-associated-Death', 'Death-associated-Immunologic Deficiency Syndromes', 'Immunologic Deficiency Syndromes-associated-Renal Insufficiency, Chronic', 'Renal Insufficiency, Chronic-associated-Immunologic Deficiency Syndromes', 'FGF23-associated-Death', 'Death-associated-FGF23', 'FGF23-associated-Renal Insufficiency, Chronic', 'Renal Insufficiency, Chronic-associated-FGF23', 'PTH-associated-Death', 'Death-associated-PTH', 'PTH-associated-Renal Insufficiency, Chronic', 'Renal Insufficiency, Chronic-associated-PTH', 'ESR1-define-Breast Neoplasms', 'MAPT-predict-Atrophy', 'PGR-define-Breast Neoplasms', 'MAPT-predict-Alzheimer Disease', 'EGFR-define-Breast Neoplasms', 'Atrophy-provide-Neurodegenerative Diseases', 'Atrophy-provide-Alzheimer Disease', 'MAPT-provide-Neurodegenerative Diseases', 'Idiopathic Pulmonary Fibrosis-paralleled-Hypotension', 'Hearing Loss, Central-correspond-GSTM1', 'IL6-involved-Intervertebral Disc Degeneration', 'CILP-involved-Intervertebral Disc Degeneration', 'Peripheral Arterial Disease-accelerate-IL6', 'Peripheral Arterial Disease-accelerate-VWF', 'Spinal Cord Injuries-provide-CRP', 'RBP4-evaluate-INS', 'Diabetes Mellitus-evaluate-Glucose Metabolism Disorders', 'Diabetes Mellitus-include-Glucose Metabolism Disorders', 'RBP4-evaluate-Glucose Metabolism Disorders', 'RBP4-play-INS', 'Diabetes Mellitus-evaluate-INS', 'Diabetes Mellitus-include-INS', 'RBP4-play-Diabetes Mellitus', 'PSMD11-associated-FOXO4', 'FOXO4-associated-PSMD11', 'NLRP3-implicated-Periodontitis', 'Hypertension-avoid-INS', 'FOXO4-associated-SOX9', 'SOX9-associated-FOXO4', 'FOXO4-associated-ACAN', 'ACAN-associated-FOXO4', 'IL1B-implicated-Periodontitis', 'rs4612666-implicated-Periodontitis', 'PSMD11-promote-Osteoarthritis', 'FOXO4-promote-Osteoarthritis', 'rs1143634-implicated-Periodontitis', 'FGFR2-correlated-Pulmonary Disease, Chronic Obstructive', 'FOXO4-promote-Lymphoproliferative Disorders', 'SST-result-INS', 'CTSK-include-Osteoporosis', 'SOST-include-Osteoporosis', 'Stroke-related-Neoplasms', 'CYP17A1-associated-CYP19A1', 'CYP19A1-associated-CYP17A1', 'CXCR4-include-HIV Infections', 'CCR5-include-HIV Infections', 'Melanoma-exclude-Sarcoma', 'ALOX15-associated-CRP', 'CRP-associated-ALOX15', 'TP63-exclude-Melanoma', 'rs2619112-associated-CRP', 'CRP-associated-rs2619112', 'ALOX15-associated-Fractures, Bone', 'Fractures, Bone-associated-ALOX15', 'KL-identify-RAB8A', 'rs2619112-associated-Fractures, Bone', 'Fractures, Bone-associated-rs2619112', 'TP63-exclude-Sarcoma', 'DES-exclude-Melanoma', 'DES-exclude-Sarcoma', 'Alzheimer Disease-assessed-CYP19A1', 'LOXL2-considered-Microaneurysm', 'LOXL4-considered-Microaneurysm', 'Coronary Artery Disease-determined-VEGFA', 'Coronary Artery Disease-determined-PGF', 'Doxorubicin-associated-MIR375', 'MIR375-associated-Doxorubicin', 'Inflammation-associated-CRP', 'CRP-associated-Inflammation', 'CD4-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-CD4', 'Inflammation-associated-IL6', 'IL6-associated-Inflammation', 'CD8A-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-CD8A', 'Neurodegenerative Diseases-compared-Dementia', 'MAPT-compared-Dementia', 'NRGN-compared-Dementia', 'IL10-foster-rs1800795', 'FGF23-include-KL', 'Parkinson Disease-include-KL', 'Obesity-analyzed-SIRT1', 'Obesity-analyzed-rs7895833', 'Parkinson Disease-associated-Parkinson Disease, Secondary', 'Parkinson Disease, Secondary-associated-Parkinson Disease', 'TNFSF12-associated-Sarcopenia', 'Sarcopenia-associated-TNFSF12', 'MAPT-associated-Parkinson Disease, Secondary', 'Parkinson Disease, Secondary-associated-MAPT', 'MAPT-associated-Parkinson Disease', 'Parkinson Disease-associated-MAPT', 'Sarcopenia-associated-ADIPOQ', 'ADIPOQ-associated-Sarcopenia', 'CCDC62-associated-Parkinson Disease, Secondary', 'Parkinson Disease, Secondary-associated-CCDC62', 'CCDC62-remain-Parkinson Disease', 'rs2942168-associated-Parkinson Disease, Secondary', 'Parkinson Disease, Secondary-associated-rs2942168', 'rs2942168-associated-Parkinson Disease', 'Parkinson Disease-associated-rs2942168', 'rs12817488-associated-Parkinson Disease, Secondary', 'Parkinson Disease, Secondary-associated-rs12817488', 'rs12817488-remain-Parkinson Disease', 'Inflammation-induced-CRP', 'Huntington Disease-produce-NFKB1', 'Huntington Disease-produce-NFKB2', 'GGH-confounded-Visceral Pain', 'IGF1-associated-Alzheimer Disease', 'Alzheimer Disease-associated-IGF1', 'IGFBP3-associated-Alzheimer Disease', 'Alzheimer Disease-associated-IGFBP3', 'Alzheimer Disease-affect-IGF1', 'LEP-linked-Inflammation', 'Alzheimer Disease-affect-IGFBP3', 'RECQL4-lead-Neoplasms', 'Periodontitis-consider-CD4', 'Periodontitis-consider-CD8A', 'FGF23-related-Cardiovascular Diseases', 'KL-related-Cardiovascular Diseases', 'CRP-predict-Death', 'CD4-associated-ALB', 'ALB-associated-CD4', 'CD4-associated-Triglycerides', 'Triglycerides-associated-CD4', 'CYP24A1-associated-Calcinosis', 'Calcinosis-associated-CYP24A1', 'KL-associated-Calcinosis', 'Calcinosis-associated-KL', 'PTEN-suppress-AKT1', 'Disorders of Sex Development-provide-Osteoporosis', 'PTEN-suppress-Disorders of Sex Development', 'PTEN-provide-Osteoporosis', 'Disorders of Sex Development-suppress-AKT1', 'AKT1-provide-Osteoporosis', 'Metabolic Syndrome-alter-INS', 'SHBG-involved-INS', 'ADIPOQ-involved-INS', 'SHBG-involved-Metabolic Syndrome', 'ADIPOQ-involved-Metabolic Syndrome', 'Metabolic Syndrome-alter-GCG', 'Glioma-arrayed-CCL2', 'Glioma-arrayed-CCL7', 'CRP-compare-CST3', 'CRP-reflect-CST3', 'CRP-reflect-Inflammation', 'CRP-compare-Inflammation', 'Inflammation-reflect-CST3', 'Glioma-arrayed-CDKN1A', 'Glioma-arrayed-COPG1', 'Glioma-arrayed-CSF2RB', 'SIRT1-regulate-ATG7', 'SIRT1-become-Osteoarthritis', 'Glioma-arrayed-CXCL1', 'CRP-associated-EPO', 'EPO-associated-CRP', 'CRP-associated-Anemia', 'Anemia-associated-CRP', 'Glioma-arrayed-SAA4', 'Glioma-arrayed-TP53', 'SYP-reduced-Alzheimer Disease', 'SYP-reduced-Death', 'CHAT-reduced-Alzheimer Disease', 'CHAT-reduced-Death', 'CRP-associated-Sarcopenia', 'Sarcopenia-associated-CRP', 'CST3-associated-Sarcopenia', 'Sarcopenia-associated-CST3', 'ALB-associated-Sarcopenia', 'Sarcopenia-associated-ALB', 'Papilledema-treated-COL17A1', 'Tonsillitis-enrolled-VDR', 'Tonsillitis-undergo-ZNF410', 'CD8A-identified-Death', 'TRPM8-treat-TRPV1', 'Starch-treat-TRPV1', 'Atrial Fibrillation-include-Immune Complex Diseases', 'PRRX1-include-Immune Complex Diseases', 'CAV1-include-Immune Complex Diseases', 'CAV2-include-Immune Complex Diseases', 'ZFHX3-include-Immune Complex Diseases', 'ADIPOQ-related-INS', 'Plaque, Amyloid-compare-Alzheimer Disease', 'Plaque, Amyloid-compare-CHAT', 'Plaque, Amyloid-immunostaining-CHAT', 'Plaque, Amyloid-compare-SYP', 'Plaque, Amyloid-immunostaining-SYP', 'Lipodystrophy-result-BSCL2', 'Lipodystrophy-encode-BSCL2', 'Lipodystrophy-result-AGPAT2', 'BDNF-associated-Atrophy', 'Atrophy-associated-BDNF', 'SLTM-associated-Atrophy', 'Atrophy-associated-SLTM', 'PLCL1-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-PLCL1', 'GGH-increase-INS', 'TMPRSS5-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-TMPRSS5', 'INS-associated-ADIPOQ', 'ADIPOQ-associated-INS', 'ADIPOQ-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-ADIPOQ', 'ITGB1-used-Alzheimer Disease', 'RAB7A-used-Alzheimer Disease', 'ALDOA-treat-Osteosarcoma', 'Death-related-Cardiovascular Diseases', 'Death-predict-IGF1', 'BCL2L11-correlated-CRP', 'GGTLC3-associated-Metabolic Syndrome', 'Metabolic Syndrome-associated-GGTLC3', 'BCL2L11-correlated-Uremia', 'ALPP-associated-Metabolic Syndrome', 'Metabolic Syndrome-associated-ALPP', 'Uremia-set-CRP', 'Uremia-set-IL6', 'PRDX5-include-Mitochondrial Diseases', 'TLR2-increased-Myocardial Infarction', 'Glucose Metabolism Disorders-involve-LEP', 'Glucose Metabolism Disorders-involve-BGLAP', 'TLR3-increased-Myocardial Infarction', 'TLR4-increased-Myocardial Infarction', 'PIK3CG-sequence-Atherosclerosis', 'ACP2-associated-Hypoglycemia', 'Hypoglycemia-associated-ACP2', 'NR1H3-associated-Hypoglycemia', 'Hypoglycemia-associated-NR1H3', 'SPI1-associated-Hypoglycemia', 'Hypoglycemia-associated-SPI1', 'PIK3CG-demonstrate-Atherosclerosis', 'SLC17A4-demonstrate-Atherosclerosis', 'PTX3-associated-CRP', 'CRP-associated-PTX3', 'PTX3-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-PTX3', 'CD8A-applied-Immune System Diseases', 'APOE-related-Dementia', 'HK3-show-Primary Ovarian Insufficiency', 'ESR1-show-Primary Ovarian Insufficiency', 'BRSK1-show-Primary Ovarian Insufficiency', 'rs2278493-show-Primary Ovarian Insufficiency', 'rs2234693-show-Primary Ovarian Insufficiency', 'rs12611091-show-Primary Ovarian Insufficiency', 'KL-inhibit-MAPK1', 'Eicosapentaenoic Acid-normalise-Triglycerides', 'KL-inhibit-Glucose Metabolism Disorders', 'Docosahexaenoic Acids-normalise-Triglycerides', 'Glucose Metabolism Disorders-inhibit-MAPK1', 'Eicosapentaenoic Acid-normalise-LEP', 'Triglycerides-normalise-LEP', 'Triglycerides-normalise-ADIPOQ', 'SIRT1-interact-Atherosclerosis', 'FOXO1-control-Atherosclerosis', 'Drug Hypersensitivity-associated-IL4', 'IL4-associated-Drug Hypersensitivity', 'Death-predict-MDM2', 'Leukemia, Myeloid, Acute-correlated-NPM1', 'Carcinoma, Non-Small-Cell Lung-predict-MDM2', 'IL6R-associated-CRP', 'CRP-associated-IL6R', 'TLR4-decreased-Angina Pectoris', 'SOD3-decreased-Angina Pectoris', 'PPARG-associated-INS', 'INS-associated-PPARG', 'PPARG-associated-Obesity', 'Obesity-associated-PPARG', 'PPARG-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-PPARG', 'PPARG-associated-Hypertension', 'Hypertension-associated-PPARG', 'PPARG-associated-Neoplasms', 'Neoplasms-associated-PPARG', 'PPARG-associated-Osteoarthritis', 'Osteoarthritis-associated-PPARG', 'MAPT-emerge-Neurodegenerative Diseases', 'Alzheimer Disease-tabulate-BIN1', 'NEFL-emerge-Neurodegenerative Diseases', 'Alzheimer Disease-tabulate-CLU', 'Alzheimer Disease-tabulate-PICALM', 'LCN2-Elevated-Neurologic Manifestations', 'LCN2-relate-Neurologic Manifestations', 'Neurologic Manifestations-relate-B2M', 'Peripheral Arterial Disease-associated-Atherosclerosis', 'Atherosclerosis-associated-Peripheral Arterial Disease', 'MIR99B-compared-Melanoma', 'GAD1-divided-INS', 'MAPT-associated-APOE', 'APOE-associated-MAPT', 'GAD1-screened-Diabetes Mellitus', 'GAD1-compare-Diabetes Mellitus', 'MAPT-associated-Amyloidosis', 'Amyloidosis-associated-MAPT', 'Diabetes Mellitus-divided-INS', 'APOE-associated-Metabolic Diseases', 'Metabolic Diseases-associated-APOE', 'Inflammation-associated-Osteoarthritis', 'Osteoarthritis-associated-Inflammation', 'IL6-associated-Osteoarthritis', 'Osteoarthritis-associated-IL6', 'GH1-impair-INS', 'PRKAA1-mitigate-Drug-Related Side Effects and Adverse Reactions', 'CRP-predict-Acute Kidney Injury', 'ALB-predict-Death', 'ALB-predict-Acute Kidney Injury', 'GIP-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-GIP', 'Glucose-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-Glucose', 'INS-known-GIP', 'ESR1-associated-Breast Neoplasms', 'Breast Neoplasms-associated-ESR1', 'ESR1-associated-Osteoporosis', 'Osteoporosis-associated-ESR1', 'ESR2-associated-Breast Neoplasms', 'Breast Neoplasms-associated-ESR2', 'ESR2-associated-Osteoporosis', 'Osteoporosis-associated-ESR2', 'NEK2-mediate-PTEN', 'NEK2-mediate-Carcinoma, Hepatocellular', 'Carcinoma, Hepatocellular-mediate-PTEN', 'FGF21-associated-INS', 'INS-associated-FGF21', 'FGF21-associated-Glucose Metabolism Disorders', 'Glucose Metabolism Disorders-associated-FGF21', 'Atherosclerosis-study-Renal Insufficiency, Chronic', 'VTN-include-MYOC', 'ELN-include-MYOC', 'Atherosclerosis-study-HIV Infections', 'Hyaluronic Acid-include-MYOC', 'Atherosclerosis-study-Immunologic Deficiency Syndromes', 'SRD5A1-alter-Prostatic Hyperplasia', 'AZGP1-implicated-INS', 'AZGP1-implicated-Obesity', 'IL6-elevated-Dementia', 'APOE-increase-Neurodegenerative Diseases', 'MAPT-increase-Neurodegenerative Diseases', 'NEFL-phosphorylated-MAPT', 'GSTM1-sulfate-GSTP1', 'INS-associated-SIRT1', 'SIRT1-associated-INS', 'Atherosclerosis-associated-SIRT1', 'SIRT1-associated-Atherosclerosis', 'Nerve Degeneration-treat-AKT1', 'Nerve Degeneration-treat-MTOR', 'BGLAP-assessed-PTH', 'Calcitriol-measured-Calcifediol', 'BGLAP-assessed-Calcifediol', 'Calcitriol-assessed-PTH', 'SIRT1-influence-SOST', 'SIRT1-play-Osteoporotic Fractures', 'Osteoporotic Fractures-influence-SOST', 'IL6-associated-Aortic Aneurysm, Abdominal', 'Aortic Aneurysm, Abdominal-associated-IL6', 'SIRT1-determined-Osteoporotic Fractures', 'MAPT-assessed-Drug Hypersensitivity', 'Hyperhomocysteinemia-explain-Atherosclerosis', 'DRD2-examined-Alzheimer Disease', 'SESN2-compare-SESN1', 'SESN3-compare-SESN1', 'INS-contribute-SLC2A4', 'CD4-associated-AMH', 'AMH-associated-CD4', 'ENC1-expand-TMEM106B', 'UNC5C-expand-TMEM106B', 'ENC1-expand-TDP-43 Proteinopathies', 'IL2-compared-Dementia', 'IL6-compared-Dementia', 'UNC5C-expand-TDP-43 Proteinopathies', 'IL10-compared-Dementia', 'NOS3-upregulate-PRKCA', 'NOS3-upregulate-Infliximab', 'ALB-associated-Diabetes Mellitus, Type 2', 'Diabetes Mellitus, Type 2-associated-ALB', 'ALB-measured-Diabetes Mellitus, Type 2', 'ADIPOQ-include-INS', 'ADIPOQ-associated-Obesity', 'Obesity-associated-ADIPOQ', 'ADIPOQ-include-Obesity', 'ADIPOQ-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-ADIPOQ', 'ADIPOQ-include-Diabetes Mellitus', 'LMNA-encode-EMD', 'IGF1-associated-Aortic Aneurysm, Abdominal', 'Aortic Aneurysm, Abdominal-associated-IGF1', 'INS-evidence-TNF', 'EMD-encode-Muscular Dystrophy, Emery-Dreifuss', 'IGFBP3-associated-Aortic Aneurysm, Abdominal', 'Aortic Aneurysm, Abdominal-associated-IGFBP3', 'Insulin Resistance-associated-Glucose Intolerance', 'Glucose Intolerance-associated-Insulin Resistance', 'Insulin Resistance-associated-INS', 'INS-associated-Insulin Resistance', 'Insulin Resistance-associated-TNF', 'TNF-associated-Insulin Resistance', 'Insulin Resistance-evidence-TNF', 'Glucose Intolerance-evidence-TNF', 'CST3-contribute-INS', 'TEP1-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-TEP1', 'TEP1-associated-Cerebral Infarction', 'Cerebral Infarction-associated-TEP1', 'TNKS-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-TNKS', 'TNKS-associated-Cerebral Infarction', 'Cerebral Infarction-associated-TNKS', 'TERT-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-TERT', 'TERT-evaluated-Inflammation', 'TERT-associated-Cerebral Infarction', 'Cerebral Infarction-associated-TERT', 'IL6-associated-Ataxia', 'Ataxia-associated-IL6', 'TERF2IP-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-TERF2IP', 'CRP-associated-Ataxia', 'Ataxia-associated-CRP', 'TERF2IP-associated-Cerebral Infarction', 'Cerebral Infarction-associated-TERF2IP', 'TNKS2-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-TNKS2', 'TNKS2-associated-Cerebral Infarction', 'Cerebral Infarction-associated-TNKS2', 'UCP2-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-UCP2', 'UCP2-associated-Cerebral Infarction', 'Cerebral Infarction-associated-UCP2', 'CXCL5-determined-NPEPPS', 'CXCL5-demonstrate-NPEPPS', 'CXCL12-determined-NPEPPS', 'CXCL12-demonstrate-NPEPPS', 'CXCL5-determined-Prostatic Neoplasms', 'CXCL5-use-Prostatic Neoplasms', 'CXCL12-determined-Prostatic Neoplasms', 'CXCL12-use-Prostatic Neoplasms', 'IL6-associated-Pain', 'Pain-associated-IL6', 'Diabetes Mellitus-result-FST', 'Diabetes Mellitus-result-SHBG', 'APOE-precede-CRP', 'APOE-precede-Death', 'NEFL-phosphorylate-MAPT', 'NRGN-phosphorylate-MAPT', 'CHI3L1-phosphorylate-MAPT', 'GFAP-phosphorylate-MAPT', 'IL6-phosphorylate-MAPT', 'MAPT-phosphorylate-Alzheimer Disease', 'MAPT-use-Alzheimer Disease', 'CST3-assessed-Stroke', 'Coronary Artery Disease-associated-LMNA', 'LMNA-associated-Coronary Artery Disease', 'Coronary Artery Disease-associated-KL', 'KL-associated-Coronary Artery Disease', 'ADIPOQ-examine-Obesity', 'Inflammatory Bowel Diseases-contain-TNF', 'SIRT1-decrease-Obesity', 'BRCA1-associated-Breast Neoplasms', 'Breast Neoplasms-associated-BRCA1', 'BRCA2-associated-Breast Neoplasms', 'Breast Neoplasms-associated-BRCA2', 'Delirium-associated-CRP', 'CRP-associated-Delirium', 'Hip Fractures-associated-CRP', 'CRP-associated-Hip Fractures', 'Delirium-associated-IL6', 'IL6-associated-Delirium', 'Hip Fractures-associated-IL6', 'IL6-associated-Hip Fractures', 'CDKN2A-expose-Diabetes Mellitus', 'IL6-measured-Hypertension', 'CXCL8-measured-Hypertension', 'SHBG-contribute-Bone Diseases', 'IGF1-contribute-Bone Diseases', 'PTH-contribute-Bone Diseases', 'USP18-reduce-INS', 'USP18-reduce-Inflammation', 'Diabetes Mellitus-associated-IL6', 'IL6-associated-Diabetes Mellitus', 'Cardiovascular Diseases-associated-IL6', 'IL6-associated-Cardiovascular Diseases', 'Diabetes Mellitus-associated-CXCL8', 'CXCL8-associated-Diabetes Mellitus', 'Cardiovascular Diseases-associated-CXCL8', 'CXCL8-associated-Cardiovascular Diseases', 'Diabetes Mellitus-associated-CCL2', 'CCL2-associated-Diabetes Mellitus', 'Cardiovascular Diseases-associated-CCL2', 'CCL2-associated-Cardiovascular Diseases', 'ZMPSTE24-result-LMNA', 'LMNA-result-Atherosclerosis', 'AMH-related-INS', 'AMH-related-Polycystic Ovary Syndrome', 'EPOR-expressed-Carcinoma, Merkel Cell', 'ANXA5-used-BCL2', 'BTG2-result-Heart Arrest', 'EPO-expressed-Carcinoma, Merkel Cell', 'KCNE2-influence-Atrial Fibrillation', 'GJA5-influence-Atrial Fibrillation', 'Heart Arrest-maintain-MMP3', 'NEFL-associated-Death', 'Death-associated-NEFL', 'MAPT-associated-Death', 'Death-associated-MAPT', 'TLR3-expressed-Aortic Aneurysm, Abdominal', 'Carcinogenesis-induced-Werner Syndrome', 'WRN-induced-Carcinogenesis', 'TP53-play-Carcinogenesis', 'APOE-appear-Alzheimer Disease', 'Inflammation-involve-Atherosclerosis', 'SMAD7-involve-Inflammation', 'Inflammation-measured-IL6', 'Inflammation-measured-CRP', 'Inflammation-measured-IL1RN', 'NFKBIA-involve-Inflammation', 'VEGFA-assess-Hypoxia', 'EPO-assess-Hypoxia', 'CD4-include-CD8A', 'KLRG1-include-CD4', 'KLRG1-include-CD8A', 'Lupus Erythematosus, Systemic-measured-CD4', 'Lupus Erythematosus, Systemic-measured-CD8A', 'Lupus Erythematosus, Systemic-measured-KLRG1', 'TNFRSF11B-play-Vascular Calcification', 'Memory Disorders-correlate-Death', 'CD8A-correlate-Death', 'TNFSF11-play-Vascular Calcification', 'Sarcopenia-related-Osteoporosis', 'Sarcopenia-related-Osteoarthritis', 'CD8A-associated-Death', 'Death-associated-CD8A', 'AHCY-related-CBS', 'AHCY-related-Cerebral Infarction', 'CBS-related-Cerebral Infarction', 'Muscular Atrophy-evaluated-Osteoporotic Fractures', 'BMP4-evaluated-Osteoporotic Fractures', 'ALDH2-inactivate-AQP4', 'ALDH2-inactivate-Inflammation', 'ALDH2-inactivate-Malformations of Cortical Development, Group I', 'rs5746092-alter-SOD2', 'PTH-linked-INS', 'rs2758343-alter-SOD2', 'Inflammation-related-Sarcopenia', 'IL6-related-Sarcopenia', 'CLU-identify-Alzheimer Disease', 'CP-complement-Prostatic Neoplasms', 'PICALM-identify-Alzheimer Disease', 'PCSK9-result-Coronary Artery Disease', 'APOB-result-Coronary Artery Disease', 'APOB-confer-Coronary Artery Disease', 'CYP19A1-assessed-APOE', 'APOB-associate-Atherosclerosis', 'Atherosclerosis-associate-APOB', 'APOE-associate-Atherosclerosis', 'Atherosclerosis-associate-APOE', 'Thyroid Neoplasms-trigger-CCL17', 'Thyroid Neoplasms-trigger-CCL18', 'Malnutrition-related-Peripheral Arterial Disease', 'CRP-related-Peripheral Arterial Disease', 'TNFRSF11B-related-Peripheral Arterial Disease', 'DDIT4-upregulate-MTOR', 'Sleep Initiation and Maintenance Disorders-downregulate-DDIT4', 'BPIFB4-opening-Cardiovascular Diseases', 'TP53-associated-Lung Neoplasms', 'Lung Neoplasms-associated-TP53', 'Sleep Initiation and Maintenance Disorders-upregulate-MTOR', 'CXCR4-opening-Cardiovascular Diseases', 'XRCC1-associated-Lung Neoplasms', 'Lung Neoplasms-associated-XRCC1', 'SIRT4-investigate-Neoplasm Metastasis', 'Prostatic Hyperplasia-treated-NFASC', 'Prostatic Hyperplasia-treated-NFE2L2', 'SIRT4-suppress-Colorectal Neoplasms', 'Tooth Diseases-related-TNFSF11', 'Tooth Diseases-related-TNFRSF11B', 'Hypertension-related-INS', 'Alzheimer Disease-demonstrated-MTHFR', 'KL-associated-LCN2', 'LCN2-associated-KL', 'Infections-increase-PGC', 'Infections-increase-GAST', 'DTX3L-analyzed-Prostatic Neoplasms', 'PARP14-analyzed-Prostatic Neoplasms', 'PARP9-analyzed-Prostatic Neoplasms', 'Fibrosis-associate-Obesity', 'Obesity-associate-Fibrosis', 'GDF11-associate-Fibrosis', 'Fibrosis-associate-GDF11', 'GDF11-associate-Obesity', 'Obesity-associate-GDF11', 'CPT1A-associate-Fibrosis', 'Fibrosis-associate-CPT1A', 'CPT1A-associate-Obesity', 'Obesity-associate-CPT1A', 'PPARG-associate-Fibrosis', 'Fibrosis-associate-PPARG', 'PPARG-associate-Obesity', 'Obesity-associate-PPARG', 'COL1A1-associate-Fibrosis', 'Fibrosis-associate-COL1A1', 'COL1A1-associate-Obesity', 'Obesity-associate-COL1A1', 'CLU-correlate-IL6', 'Osteoporosis-correlate-IL6', 'BGLAP-correlate-INS', 'BGLAP-correlate-Glucose', 'Glucose-attenuated-INS', 'NAMPT-related-INS', 'NAMPT-related-Obesity', 'NAMPT-related-Inflammation', 'SHBG-associated-INS', 'INS-associated-SHBG', 'LEP-involved-Glucose', 'SHBG-associated-Metabolic Syndrome', 'Metabolic Syndrome-associated-SHBG', 'LEP-involved-Inflammation', 'TAT-inhibit-MME', 'Kidney Failure, Chronic-reach-Diabetic Nephropathies', 'Alcoholism-found-Hypertension', 'MIR132-compare-Diabetic Nephropathies', 'Alcoholism-found-Diabetes Mellitus', 'MIR223-compare-Diabetic Nephropathies', 'MIR326-compare-Diabetic Nephropathies', 'Osteosarcoma-promote-MBTD1', 'Fructosamine-associated-Death', 'Death-associated-Fructosamine', 'TALAM1-regulate-MALAT1', 'Fructosamine-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-Fructosamine', 'Breast Neoplasms-regulate-TALAM1', 'Breast Neoplasms-regulate-MALAT1', 'Glucose-associated-Death', 'Death-associated-Glucose', 'Galactose-related-Inflammation', 'N-Acetylneuraminic Acid-related-Inflammation', 'Acetylglucosamine-related-Inflammation', 'Galactose-involve-Cerebral Infarction', 'N-Acetylneuraminic Acid-involve-Cerebral Infarction', 'Acetylglucosamine-involve-Cerebral Infarction', 'Acetylglucosamine-contribute-Cerebral Infarction', 'Cerebral Infarction-control-Obesity', 'Cerebral Infarction-control-Diabetes Mellitus', 'Cerebral Infarction-control-Hypertension', 'Polysaccharides-derive-Obesity', 'Polysaccharides-control-Obesity', 'Polysaccharides-derive-Diabetes Mellitus', 'Polysaccharides-control-Diabetes Mellitus', 'Polysaccharides-derive-Hypertension', 'Polysaccharides-control-Hypertension', 'Monosaccharides-associated-Obesity', 'Obesity-associated-Monosaccharides', 'Monosaccharides-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-Monosaccharides', 'Monosaccharides-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-Monosaccharides', 'Disaccharides-associated-Obesity', 'Obesity-associated-Disaccharides', 'Disaccharides-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-Disaccharides', 'Disaccharides-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-Disaccharides', 'Fructose-associated-Irritable Bowel Syndrome', 'Irritable Bowel Syndrome-associated-Fructose', 'Fructose-associated-Pain', 'Pain-associated-Fructose', 'Nadroparin-show-Heparin', 'Lactose-associated-Irritable Bowel Syndrome', 'Irritable Bowel Syndrome-associated-Lactose', 'Lactose-associated-Pain', 'Pain-associated-Lactose', 'Nadroparin-show-Heparin, Low-Molecular-Weight', 'Neoplasms-require-Fractures, Bone', 'Heparin-require-Fractures, Bone', 'Heparin, Low-Molecular-Weight-require-Fractures, Bone', 'Heparin-compare-Heparin, Low-Molecular-Weight', 'Enoxaparin-compare-Heparin, Low-Molecular-Weight', 'Heparin-compare-Venous Thrombosis', 'Heparin, Low-Molecular-Weight-compare-Venous Thrombosis', 'Enoxaparin-compare-Venous Thrombosis', 'Acarbose-attenuate-Hypotension', 'Heparin, Low-Molecular-Weight-replace-Renal Insufficiency', 'Heparin-replace-Renal Insufficiency', 'Venous Thromboembolism-related-Neoplasms', 'Heparin-recommended-Venous Thromboembolism', 'Enoxaparin-reduce-Death', 'Etoposide-studied-Anthracyclines', 'Leukemia, Myeloid, Acute-studied-Anthracyclines', 'Fatty Acids, Nonesterified-use-Diabetes Mellitus', 'Lactulose-given-Sorbitol', 'Sphingomyelins-use-Diabetes Mellitus', 'Gait Disorders, Neurologic-use-Cholesterol', 'Constipation-given-Lactulose', 'Constipation-given-Sorbitol', 'Sphingomyelins-diagnosed-Diabetes Mellitus', 'Triglycerides-shift-Dyslipidemias', 'Fatty Acids, Omega-3-recognized-Dyslipidemias', 'Phosphatidylcholines-use-Diabetes Mellitus', 'Fatty Acids, Omega-3-influence-Hypertriglyceridemia', 'Lysophosphatidylcholines-diagnosed-Diabetes Mellitus', 'Inflammation-suggested-Fatty Acids, Omega-3', 'Cardiovascular Diseases-associated-Triglycerides', 'Triglycerides-associated-Cardiovascular Diseases', 'Inflammation-suggested-Fatty Acids, Unsaturated', 'Cardiovascular Diseases-associated-Cholesterol', 'Cholesterol-associated-Cardiovascular Diseases', 'Ceramides-include-Sphingolipids', 'Sphingolipids-associated-Death', 'Death-associated-Sphingolipids', 'Cholesterol-compare-Prediabetic State', 'Ceramides-associated-Death', 'Death-associated-Ceramides', 'Triglycerides-compare-Prediabetic State', 'Fatty Acids-measured-Leg Ulcer', 'Glaucoma-treated-Travoprost', 'Glaucoma-treated-Bimatoprost', 'Sphingomyelins-altered-Alzheimer Disease', 'Sphingomyelins-associated-Alzheimer Disease', 'Alzheimer Disease-associated-Sphingomyelins', 'Ceramides-vary-APOE', 'Phosphatidylcholines-altered-Alzheimer Disease', 'Sphingomyelins-vary-APOE', 'Metabolic Syndrome-accompanied-Diabetes Mellitus', 'Obesity-accompanied-Diabetes Mellitus', 'Fatty Acids-recruit-Triglycerides', 'Triglycerides-accompanied-Diabetes Mellitus', 'Glucose-recruit-Fatty Acids', 'Glucose-recruit-Triglycerides', 'Metabolic Syndrome-accompanied-Cholesterol', 'Metabolic Syndrome-control-Cholesterol', 'Cholesterol-accompanied-Diabetes Mellitus', 'Fatty Acids, Omega-3-attenuate-Alzheimer Disease', 'Fatty Acids-attenuate-Alzheimer Disease', 'Docosahexaenoic Acids-attenuate-Alzheimer Disease', 'Eicosapentaenoic Acid-associated-Dementia', 'Dementia-associated-Eicosapentaenoic Acid', 'Docosahexaenoic Acids-associated-Dementia', 'Dementia-associated-Docosahexaenoic Acids', 'Fatty Acids, Omega-3-associated-Fractures, Bone', 'Fractures, Bone-associated-Fatty Acids, Omega-3', 'Eicosapentaenoic Acid-associated-Fractures, Bone', 'Fractures, Bone-associated-Eicosapentaenoic Acid', 'Cholesterol-associated-Glucose', 'Glucose-associated-Cholesterol', 'Cholesterol-defined-Glucose', 'Triglycerides-associated-Glucose', 'Glucose-associated-Triglycerides', 'Triglycerides-defined-Glucose', 'Diabetes Mellitus-defined-Glucose', 'Diabetes Mellitus-associated-Cholesterol', 'Cholesterol-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-Triglycerides', 'Triglycerides-associated-Diabetes Mellitus', 'Fatty Acids, Omega-3-associated-Inflammation', 'Inflammation-associated-Fatty Acids, Omega-3', 'Eicosapentaenoic Acid-associated-Inflammation', 'Inflammation-associated-Eicosapentaenoic Acid', 'Docosahexaenoic Acids-associated-Inflammation', 'Inflammation-associated-Docosahexaenoic Acids', 'Dementia-include-Sphingomyelins', 'Dementia-include-Ceramides', 'Docosahexaenoic Acids-related-Dementia', 'Eicosapentaenoic Acid-related-Dementia', 'Cardiovascular Diseases-presented-Dyslipidemias', 'Cardiovascular Diseases-observed-Triglycerides', 'INS-measured-Glucose', '3-Hydroxybutyric Acid-measured-Glucose', 'Triglycerides-measured-Glucose', 'Cholesterol-measured-Glucose', 'Fatty Acids-measured-Glucose', 'Cholesterol-reduced-Diabetes Mellitus', 'Triglycerides-reduced-Diabetes Mellitus', 'Triglycerides-lower-Glucose Intolerance', 'Cholesterol-lower-Glucose Intolerance', 'Cholesterol-associated-APOB', 'APOB-associated-Cholesterol', 'Phospholipids-change-Coronary Artery Disease', 'Cholesterol-associated-Migraine with Aura', 'Migraine with Aura-associated-Cholesterol', 'Cholesterol-associated-Headache', 'Headache-associated-Cholesterol', 'Triglycerides-contained-Diglycerides', 'Triglycerides-associated-Migraine with Aura', 'Migraine with Aura-associated-Triglycerides', 'Triglycerides-associated-Headache', 'Headache-associated-Triglycerides', 'Cholesterol-generate-Oxysterols', 'Smith-Lemli-Opitz Syndrome-generate-Oxysterols', 'Atorvastatin-associated-Cholesterol', 'Cholesterol-associated-Atorvastatin', 'Atorvastatin-associated-Death', 'Death-associated-Atorvastatin', 'Atorvastatin-associated-Ischemia', 'Ischemia-associated-Atorvastatin', 'Starch-observed-Fatty Acids, Unsaturated', 'Phosphatidylcholines-degraded-Fatty Acids, Nonesterified', 'Triglycerides-receive-Fatty Acids', 'Thioctic Acid-affect-Glucose', 'Phosphatidylcholines-degraded-Brain Ischemia', 'Triglycerides-receive-INS', 'Capsaicin-affect-Glucose', 'Nervous System Diseases-affect-Glucose', 'Triglycerides-receive-Obesity', 'Thioctic Acid-receive-Diabetic Neuropathies', 'Triglycerides-receive-Diabetes Mellitus', 'Capsaicin-receive-Diabetic Neuropathies', 'Obesity-constitute-Metabolic Syndrome', 'Obesity, Abdominal-constitute-Metabolic Syndrome', 'Dyslipidemias-constitute-Metabolic Syndrome', 'Hyperglycemia-constitute-Metabolic Syndrome', 'Hypertension-constitute-Metabolic Syndrome', 'Triglycerides-constitute-Metabolic Syndrome', 'Cholesterol-constitute-Metabolic Syndrome', 'Insulin Lispro-compare-Insulin Glargine', 'Insulin Lispro-compare-Glucose', 'Insulin Lispro-added-Glucose', 'Insulin Glargine-added-Glucose', 'Cholesterol-increase-Coronary Artery Disease', 'Triglycerides-increase-Coronary Artery Disease', 'Daptomycin-compared-Vancomycin', 'Daptomycin-receive-Vancomycin', 'Daptomycin-compared-Gentamicins', 'Daptomycin-receive-Gentamicins', 'Glutathione-follow-HMOX1', 'Glutathione Disulfide-follow-HMOX1', 'Nivolumab-evaluate-Ipilimumab', 'rs4988300-associated-LRP5', 'LRP5-associated-rs4988300', 'LRP5-associated-Osteoporosis', 'Osteoporosis-associated-LRP5', 'VEGFA-contribute-Thromboembolism', 'LRP5-associated-Fractures, Bone', 'Fractures, Bone-associated-LRP5', 'rs4988300-associated-Osteoporosis', 'Osteoporosis-associated-rs4988300', 'Ranibizumab-contribute-Thromboembolism', 'rs4988300-associated-Fractures, Bone', 'Fractures, Bone-associated-rs4988300', 'Bevacizumab-contribute-Thromboembolism', 'rs634008-associated-Osteoporosis', 'Osteoporosis-associated-rs634008', 'rs634008-associated-Fractures, Bone', 'Fractures, Bone-associated-rs634008', 'rs2420915-reduce-rs6430491', 'rs2420915-reduce-rs2593704', 'rs2420915-enhance-Pulmonary Disease, Chronic Obstructive', 'Pulmonary Disease, Chronic Obstructive-reduce-rs6430491', 'Pulmonary Disease, Chronic Obstructive-reduce-rs2593704', 'rs104893877-indicate-rs768838511', 'rs104893877-indicate-rs749476922', 'Neurotoxicity Syndromes-indicate-rs768838511', 'Neurotoxicity Syndromes-indicate-rs749476922', 'PLA2G6-associated-Ataxia', 'Ataxia-associated-PLA2G6', 'rs199935023-associated-Ataxia', 'Ataxia-associated-rs199935023', 'rs7903146-associated-rs7902146', 'rs7902146-associated-rs7903146', 'TCF7L2-associated-rs7902146', 'rs7902146-associated-TCF7L2', 'TCF7L2-affect-rs7902146', 'TCF7L2-associated-Bradycardia', 'Bradycardia-associated-TCF7L2', 'TCF7L2-associated-Glucose Metabolism Disorders', 'Glucose Metabolism Disorders-associated-TCF7L2', 'rs7903146-associated-Bradycardia', 'Bradycardia-associated-rs7903146', 'rs7903146-associated-Glucose Metabolism Disorders', 'Glucose Metabolism Disorders-associated-rs7903146', 'Bradycardia-affect-rs7902146', 'rs7902146-affect-Glucose Metabolism Disorders', 'rs917997-associated-rs20544', 'rs20544-associated-rs917997', 'rs2234693-include-Alzheimer Disease', 'rs9340799-include-Alzheimer Disease', 'rs2736122-associated-Coronary Artery Disease', 'Coronary Artery Disease-associated-rs2736122', 'rs2736122-associated-Stroke', 'Stroke-associated-rs2736122', 'Alzheimer Disease-associated-ESR2', 'ESR2-associated-Alzheimer Disease', 'rs2853668-associated-Coronary Artery Disease', 'Coronary Artery Disease-associated-rs2853668', 'rs10757278-associated-Coronary Artery Disease', 'Coronary Artery Disease-associated-rs10757278', 'rs10757278-marked-Coronary Artery Disease', 'rs2853668-associated-Stroke', 'Stroke-associated-rs2853668', 'Alzheimer Disease-associated-rs944045', 'rs944045-associated-Alzheimer Disease', 'Alzheimer Disease-associated-rs1256062', 'rs1256062-associated-Alzheimer Disease', 'Alzheimer Disease-associated-rs10144225', 'rs10144225-associated-Alzheimer Disease', 'Alzheimer Disease-associated-rs2274705', 'rs2274705-associated-Alzheimer Disease', 'rs10757278-associated-Peripheral Vascular Diseases', 'Peripheral Vascular Diseases-associated-rs10757278', 'rs10757278-marked-Peripheral Vascular Diseases', 'rs1333049-associated-Coronary Artery Disease', 'Coronary Artery Disease-associated-rs1333049', 'rs1333049-marked-Coronary Artery Disease', 'rs1333049-associated-Peripheral Vascular Diseases', 'Peripheral Vascular Diseases-associated-rs1333049', 'rs1333049-marked-Peripheral Vascular Diseases', 'rs1079866-associated-Breast Neoplasms', 'Breast Neoplasms-associated-rs1079866', 'rs7821178-associated-Breast Neoplasms', 'Breast Neoplasms-associated-rs7821178', 'rs7069102-associated-Metabolic Diseases', 'Metabolic Diseases-associated-rs7069102', 'rs7069102-associated-Vascular Calcification', 'Vascular Calcification-associated-rs7069102', 'rs2517388-associated-Breast Neoplasms', 'Breast Neoplasms-associated-rs2517388', 'rs2273773-associated-Metabolic Diseases', 'Metabolic Diseases-associated-rs2273773', 'rs2273773-associated-Vascular Calcification', 'Vascular Calcification-associated-rs2273773', 'rs2222823-associated-Cerebral Small Vessel Diseases', 'Cerebral Small Vessel Diseases-associated-rs2222823', 'rs2811712-associated-Cerebral Small Vessel Diseases', 'Cerebral Small Vessel Diseases-associated-rs2811712', 'APOE-determined-rs429358', 'APOE-find-rs7412', 'rs10757278-associated-Myocardial Infarction', 'Myocardial Infarction-associated-rs10757278', 'KL-associated-Glucose Metabolism Disorders', 'Glucose Metabolism Disorders-associated-KL', 'TP53-mutated-Myelodysplastic Syndromes', 'TP53-mutated-Leukemia, Myeloid, Acute', 'Obesity-met-Hypotension', 'Obesity-met-Triglycerides', 'Hypertension-associated-Obesity', 'Obesity-associated-Hypertension', 'Infections-compare-ACE2', 'Lewy Body Disease-include-Alzheimer Disease', 'Dementia-include-Alzheimer Disease', 'Dementia, Vascular-include-Alzheimer Disease', 'Brain Diseases-include-Alzheimer Disease', 'Lewy Body Disease-include-Dementia', 'Dementia, Vascular-include-Dementia', 'Brain Diseases-include-Dementia', 'TARDBP-include-Alzheimer Disease', 'TARDBP-include-Dementia', 'Hypocalcemia-use-Denosumab', 'Denosumab-use-Osteoporosis', 'Graft Occlusion, Vascular-associated-Hypertension', 'Hypertension-associated-Graft Occlusion, Vascular', 'Graft Occlusion, Vascular-associated-CRP', 'CRP-associated-Graft Occlusion, Vascular', 'EGFR-harbor-Lung Neoplasms', 'Endometriosis-carry-rs2016347', 'Polycystic Ovary Syndrome-carry-rs2016347', 'Neurotoxicity Syndromes-decrease-Parkinson Disease', 'Leishmaniasis, Visceral-decrease-Parkinson Disease', 'Neurotoxicity Syndromes-regarded-Leishmaniasis, Visceral', 'rs2016347-show-Hypertension', 'Cholesterol-associated-Death', 'Death-associated-Cholesterol', 'Hyperuricemia-associated-Inflammation', 'Inflammation-associated-Hyperuricemia', 'TERT-observed-Thyroid Neoplasms', 'TERT-observed-Neoplasms', 'TERT-observed-Thyroid Carcinoma, Anaplastic', 'PTCSC3-involved-Thyroid Neoplasms', 'PTCSC3-involved-Glioma', 'KL-associated-Renal Insufficiency, Chronic', 'Renal Insufficiency, Chronic-associated-KL', 'KL-associated-Chronic Kidney Disease-Mineral and Bone Disorder', 'Chronic Kidney Disease-Mineral and Bone Disorder-associated-KL', 'KL-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-KL', 'Nervous System Diseases-evaluate-Alzheimer Disease', 'Nervous System Diseases-reflect-Alzheimer Disease', 'H1-4-caused-Genetic Diseases, Inborn', 'Alzheimer Disease-investigate-APOE', 'Breast Neoplasms-diagnosed-Neoplasms', 'RUFY3-diagnosed-Neoplasms', 'Neoplasms-measured-Fluorodeoxyglucose F18', 'Fluorodeoxyglucose F18-measured-Carcinoma, Non-Small-Cell Lung', 'Atorvastatin-reduce-Hematoma', 'NEFL-suggested-Neurodegenerative Diseases', 'Atorvastatin-reduce-Hematoma, Subdural, Chronic', 'NEFL-suggested-Dementia', 'Amyloidosis-associated-Heredodegenerative Disorders, Nervous System', 'Heredodegenerative Disorders, Nervous System-associated-Amyloidosis', 'Amyloidosis-associated-Carpal Tunnel Syndrome', 'Carpal Tunnel Syndrome-associated-Amyloidosis', 'Amyloidosis-associated-Polyneuropathies', 'Polyneuropathies-associated-Amyloidosis', 'TTR-associated-Heredodegenerative Disorders, Nervous System', 'Heredodegenerative Disorders, Nervous System-associated-TTR', 'TTR-associated-Carpal Tunnel Syndrome', 'Carpal Tunnel Syndrome-associated-TTR', 'TTR-associated-Polyneuropathies', 'Polyneuropathies-associated-TTR', 'Glucose Intolerance-impair-Diabetes Mellitus', 'Glucose-impair-Glucose Intolerance', 'Inflammation-play-Atherosclerosis', 'SIRT6-play-Atherosclerosis', 'Hypertension-stop-Fatty Acids, Unsaturated', 'SIRT6-decreased-Angina, Stable', 'SIRT6-decreased-Acute Coronary Syndrome', 'Glucose Metabolism Disorders-expose-Death', 'Glucose-expose-Death', 'CAMSAP3-promote-Lung Neoplasms', 'CAMSAP3-induce-Heart Arrest', 'Cardiovascular Diseases-associated-Neuroaxonal Dystrophies', 'Neuroaxonal Dystrophies-associated-Cardiovascular Diseases', 'KLK11-related-Neoplasms', 'Cardiovascular Diseases-associated-APOE', 'APOE-associated-Cardiovascular Diseases', 'Neuronal Ceroid-Lipofuscinoses-caused-Metabolism, Inborn Errors', 'Genetic Diseases, Inborn-caused-Metabolism, Inborn Errors', 'MAPT-connected-Alzheimer Disease', 'Neuronal Ceroid-Lipofuscinoses-caused-TPP1', 'Genetic Diseases, Inborn-caused-TPP1', 'Non-alcoholic Fatty Liver Disease-associated-Metabolic Syndrome', 'Metabolic Syndrome-associated-Non-alcoholic Fatty Liver Disease', 'Non-alcoholic Fatty Liver Disease-associated-INS', 'INS-associated-Non-alcoholic Fatty Liver Disease', 'Valproic Acid-associated-Heart Failure', 'Heart Failure-associated-Valproic Acid', 'Valproic Acid-associated-Death', 'Death-associated-Valproic Acid', 'BACE1-involve-Alzheimer Disease', 'Acquired Immunodeficiency Syndrome-compare-Long QT Syndrome', 'Acquired Immunodeficiency Syndrome-compare-CD4', 'Cerebral Hemorrhage-related-NOTCH3', 'Cerebral Hemorrhage-screened-NOTCH3', 'Stroke-screened-NOTCH3', 'Cerebral Hemorrhage-screened-rs201118034', 'Stroke-screened-rs201118034', 'Diabetes Mellitus-considered-Alzheimer Disease', 'Diabetes Mellitus-share-MAPT', 'Alzheimer Disease-share-MAPT', 'Sleep Initiation and Maintenance Disorders-associated-Neurodegenerative Diseases', 'Neurodegenerative Diseases-associated-Sleep Initiation and Maintenance Disorders', 'Sleep Initiation and Maintenance Disorders-suggest-Neurodegenerative Diseases', 'Sleep Initiation and Maintenance Disorders-associated-APOE', 'APOE-associated-Sleep Initiation and Maintenance Disorders', 'APOE-suggest-Neurodegenerative Diseases', 'Death-compare-Viremia', 'Death-compare-CD4', 'Blister-occur-Neoplasms', 'Blister-occur-BRAF', 'Obesity-mount-Osteoarthritis', 'CRP-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-CRP', 'Obesity-implicate-LEP', 'Obesity-implicate-Fatty Acids', 'Neurodegenerative Diseases-differentiate-Alzheimer Disease', 'CDKN2A-differentiate-Alzheimer Disease', 'Encephalomyelitis-followed-Optic Neuritis', 'WWP1-increased-Hypertrophy', 'WWP1-increased-Heart Failure', 'Dementia-determine-WNT5A', 'Psychomotor Agitation-associated-WNT5A', 'WNT5A-associated-Psychomotor Agitation', 'Psychomotor Agitation-determine-WNT5A', 'Diabetes Mellitus-increase-Cardiovascular Diseases', 'INS-increase-Cardiovascular Diseases', 'Immunologic Deficiency Syndromes-suspected-Pulmonary Emphysema', 'Immunologic Deficiency Syndromes-suspected-Pulmonary Disease, Chronic Obstructive', 'Cardiomyopathies-considered-Heart Diseases', 'SERPINA1-suspected-Pulmonary Emphysema', 'TTR-considered-Heart Diseases', 'Obesity-play-INS', 'SERPINA1-suspected-Pulmonary Disease, Chronic Obstructive', 'SLC5A2-associated-Atrial Fibrillation', 'Atrial Fibrillation-associated-SLC5A2', 'SLC5A2-associated-Diabetes Mellitus, Type 2', 'Diabetes Mellitus, Type 2-associated-SLC5A2', 'AHR-involved-Metabolic Syndrome', 'AHR-involved-Diabetes Mellitus', 'Cardiovascular Diseases-include-Chronic Disease', 'Diabetes Mellitus-include-Chronic Disease', 'Oils-link-Diabetes Mellitus', 'Death-associated-Hypoglycemia', 'Hypoglycemia-associated-Death', 'rs25487-play-Carcinoma, Squamous Cell', 'Dementia-associated-Glucose', 'Glucose-associated-Dementia', 'rs25487-play-Leukoplakia, Oral', 'INS-predispose-Genetic Diseases, Inborn', 'INS-predispose-Death', 'Osteoarthritis-differentiate-Joint Diseases', 'MIF-differentiate-Joint Diseases', 'GDF15-induced-Inflammation', 'GDF15-receive-Mitochondrial Diseases', 'Glycosides-used-Heart Failure', 'Glycosides-treat-Heart Failure', 'Langer-Giedion Syndrome-suspend-Diabetes Mellitus', 'Glycosides-used-Arrhythmias, Cardiac', 'INS-suspend-Langer-Giedion Syndrome', 'INS-start-Diabetes Mellitus', 'ALB-associated-Death', 'Death-associated-ALB', 'ACE2-reported-Myocardial Infarction', 'ACE2-reported-Heart Failure', 'CRP-correlate-Infections', 'Dementia-explore-Inflammation', 'Dementia-increase-Inflammation', 'APOE-increase-Inflammation', 'Heparin, Low-Molecular-Weight-associated-Death', 'Death-associated-Heparin, Low-Molecular-Weight', 'PWRN2-protect-Death', 'Neoplasms-integrate-TERT', 'PWRN2-protect-Mitochondrial Diseases', 'INS-associated-Lung Injury', 'Lung Injury-associated-INS', 'KL-associated-Vascular Calcification', 'Vascular Calcification-associated-KL', 'KL-associated-Acromegaly', 'Acromegaly-associated-KL', 'KL-associated-Neoplasms', 'Neoplasms-associated-KL', 'Acromegaly-associated-Joint Diseases', 'Joint Diseases-associated-Acromegaly', 'KL-associated-Colonic Polyps', 'Colonic Polyps-associated-KL', 'GH1-associated-Joint Diseases', 'Joint Diseases-associated-GH1', 'NGF-provide-Pain', 'NGF-provide-Osteoarthritis', 'NOTCH3-associated-Cerebral Small Vessel Diseases', 'Cerebral Small Vessel Diseases-associated-NOTCH3', 'Parkinson Disease, Secondary-exhibit-SLC6A3', 'NOTCH3-associated-Infarction', 'Infarction-associated-NOTCH3', 'SLC6A3-exhibit-Parkinson Disease', 'NOTCH3-associated-Leukoencephalopathies', 'Leukoencephalopathies-associated-NOTCH3', 'Dementia-increase-Diabetes Mellitus', 'Diabetic Neuropathies-play-Obesity', 'Obesity-represent-Diabetic Neuropathies', 'Obesity-play-Diabetes Mellitus', 'Diabetic Neuropathies-play-INS', 'INS-represent-Diabetic Neuropathies', 'INS-play-Diabetes Mellitus', 'Tauopathies-base-Dementia', 'Tauopathies-cause-Dementia', 'Heart Failure-identify-Cardiovascular Diseases', 'Atherosclerosis-identify-Cardiovascular Diseases', 'SIRT6-unveiled-Heart Failure', 'SIRT6-unveiled-Cardiovascular Diseases', 'Death-treated-Doxorubicin', 'SIRT6-identify-Atherosclerosis', 'Seizures-alleviate-Inflammation', 'Hodgkin Disease-treated-Doxorubicin', 'SIRT6-identify-Cardiovascular Diseases', 'Death-treated-Bleomycin', 'Hodgkin Disease-treated-Bleomycin', 'Diabetes Mellitus-accord-Albuminuria', 'Neurodegenerative Diseases-termed-Synucleinopathies', 'Diabetes Mellitus-accord-ALB', 'Neurodegenerative Diseases-termed-Parkinson Disease', 'Ceramides-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-Ceramides', 'Neurodegenerative Diseases-include-Parkinson Disease', 'Parkinson Disease-include-Synucleinopathies', 'Ceramides-associated-Cerebral Small Vessel Diseases', 'Cerebral Small Vessel Diseases-associated-Ceramides', 'Ovarian Neoplasms-associated-Infertility', 'Infertility-associated-Ovarian Neoplasms', 'TERT-underlie-Ovarian Neoplasms', 'IL6-obtained-Stroke', 'NRGN-known-Alzheimer Disease', 'NRGN-known-Neurodegenerative Diseases', 'APOE-associated-Dementia', 'Dementia-associated-APOE', 'SERPINC1-diagnosed-Alzheimer Disease', 'Metabolic Diseases-linked-Mitochondrial Diseases', 'INS-linked-Mitochondrial Diseases', 'Polycystic Ovary Syndrome-compare-INS', 'Diabetes Mellitus-associated-LEP', 'LEP-associated-Diabetes Mellitus', 'Hypertension-associated-LEP', 'LEP-associated-Hypertension', 'LEP-limited-Obesity', 'Alzheimer Disease-shifting-Death', 'Alzheimer Disease-shifting-APOE', 'Sarcopenia-base-ACTN3', 'Sarcopenia-show-ACTN3', 'Seizures-base-ACTN3', 'Seizures-show-ACTN3', 'Death-present-Hyperglycemia', 'Sarcopenia-base-rs1815739', 'Sarcopenia-show-rs1815739', 'Werner Syndrome-characterized-WRN', 'MGLL-produce-Arachidonic Acid', 'Dementia-subdivided-Alzheimer Disease', 'Seizures-base-rs1815739', 'Seizures-show-rs1815739', 'Genetic Diseases, Inborn-characterized-WRN', 'Arachidonic Acid-produce-Neurodegenerative Diseases', 'MAPT-measured-Parkinson Disease', 'MAPT-measured-Parkinson Disease, Secondary', 'Fragile X Syndrome-associated-Movement Disorders', 'Movement Disorders-associated-Fragile X Syndrome', 'Doxorubicin-elevated-Trastuzumab', 'Cardiotoxicity-elevated-Trastuzumab', 'Ataxia-associated-Movement Disorders', 'Movement Disorders-associated-Ataxia', 'Breast Neoplasms-elevated-Trastuzumab', 'FMR1-associated-Movement Disorders', 'Movement Disorders-associated-FMR1', 'TP53-involve-Parkinson Disease', 'TP53-associated-Parkinson Disease', 'Parkinson Disease-associated-TP53', 'UMOD-associated-Death', 'Death-associated-UMOD', 'Synucleinopathies-associated-TP53', 'TP53-associated-Synucleinopathies', 'UMOD-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-UMOD', 'UMOD-associated-Renal Insufficiency', 'Renal Insufficiency-associated-UMOD', 'UMOD-associated-Chronic Kidney Disease-Mineral and Bone Disorder', 'Chronic Kidney Disease-Mineral and Bone Disorder-associated-UMOD', 'Heart Failure-include-Diabetes Mellitus', 'SELENOP-cause-Diabetes Mellitus', 'SELENOP-cause-Heart Failure', 'SELENOP-cause-Myocardial Reperfusion Injury', 'Lung Diseases-increase-Pleural Effusion', 'Lung Diseases-increase-Glucose', 'TSC2-describe-rs34245038', 'TSC2-diagnosed-Dental Plaque', 'Polymyositis-associated-Lung Diseases, Interstitial', 'Lung Diseases, Interstitial-associated-Polymyositis', 'Nervous System Diseases-attributed-BDNF', 'TSC2-followed-Epilepsy', 'Dermatomyositis-associated-Lung Diseases, Interstitial', 'Lung Diseases, Interstitial-associated-Dermatomyositis', 'rs34245038-diagnosed-Dental Plaque', 'rs34245038-followed-Epilepsy', 'TRPA1-reduce-Kidney Diseases', 'TRPA1-reduce-Esophageal Neoplasms', 'Malocclusion-use-TNF', 'Parkinson Disease-develop-Parkinson Disease, Secondary', 'rs421016-identified-Parkinson Disease', 'rs421016-develop-Parkinson Disease, Secondary', 'MIR182-determined-Adenocarcinoma of Lung', 'MIR182-base-Adenocarcinoma of Lung', 'MIR182-determined-Carcinoma, Squamous Cell', 'MIR182-base-Carcinoma, Squamous Cell', 'CRP-associated-Diabetes Mellitus, Type 2', 'Diabetes Mellitus, Type 2-associated-CRP', 'Alzheimer Disease-define-Neurodegenerative Diseases', 'Alzheimer Disease-detect-Neurodegenerative Diseases', 'Alzheimer Disease-define-MAPT', 'Alzheimer Disease-detect-MAPT', 'Prediabetic State-defined-Diabetes Mellitus', 'Prediabetic State-defined-Glucose', 'Neurodegenerative Diseases-use-Alzheimer Disease', 'Fibrosis-associated-Kidney Diseases', 'Kidney Diseases-associated-Fibrosis', 'KITLG-participate-Fibrosis', 'ANGPTL2-associated-Death', 'Death-associated-ANGPTL2', 'Hypertension-followed-Death', 'Glucose-followed-Death', 'Metabolic Syndrome-associated-Obesity', 'Obesity-associated-Metabolic Syndrome', 'Dementia-stratified-APOE', 'Muscle Weakness-diagnosed-Sarcopenia', 'APOE-associated-Hearing Loss', 'Hearing Loss-associated-APOE', 'Epilepsy, Temporal Lobe-stratified-APOE', 'Hypertension-diagnosed-Sarcopenia', 'Muscle Weakness-diagnosed-H19', 'Hypertension-diagnosed-H19', 'Diabetes Mellitus-categorize-INS', 'Glucose-serve-Diabetes Mellitus', 'Glucose-serve-Prediabetic State', 'Alzheimer Disease-investigated-Neurodegenerative Diseases', 'Glucose-improve-INS', 'NEFL-investigated-Neurodegenerative Diseases', 'Diabetes Mellitus-improve-INS', 'Glucose-improve-Diabetes Mellitus', 'Polycystic Ovary Syndrome-correlated-Inflammation', 'Obesity-correlated-Inflammation', 'Polycystic Ovary Syndrome-correlated-INS', 'Obesity-correlated-INS', 'Dyslipidemias-include-Metabolic Diseases', 'IDUA-serve-Osteoporotic Fractures', 'rs6831280-serve-Osteoporotic Fractures', 'LPA-associated-Coronary Artery Disease', 'Coronary Artery Disease-associated-LPA', 'UMOD-associated-Fibrosis', 'Fibrosis-associated-UMOD', 'UMOD-associated-Adenocarcinoma', 'Adenocarcinoma-associated-UMOD', 'Herpes Zoster-found-Adenoma', 'CYP11B2-found-Adenoma', 'Spinal Stenosis-obtained-Spinal Diseases', 'Lung Neoplasms-treated-ALK', 'Neoplasms-treated-ALK', 'F2RL1-associated-Hypotension', 'Hypotension-associated-F2RL1', 'F2RL1-associated-Fibrosis', 'Fibrosis-associated-F2RL1', 'Glucose Metabolism Disorders-play-Metabolic Diseases', 'Glucose Metabolism Disorders-play-Diabetes Mellitus', 'MTOR-regulate-Glucose Metabolism Disorders', 'Hypertension-detect-Aneurysm', 'AMH-lead-Hypertension', 'AMH-detect-Aneurysm', 'KL-associated-Metabolic Syndrome', 'Metabolic Syndrome-associated-KL', 'Neoplasms-develop-Venous Thromboembolism', 'Venous Thromboembolism-develop-Heparin', 'UNC5C-predict-Atrophy', 'Carcinoma, Non-Small-Cell Lung-performed-EGFR', 'Carcinoma, Non-Small-Cell Lung-performed-rs121434569', 'INS-impact-Tooth, Impacted', 'Sarcopenia-associated-Muscle Weakness', 'Muscle Weakness-associated-Sarcopenia', 'INS-impact-Diabetes Mellitus', 'Sarcopenia-result-Obesity', 'Sarcopenia-associated-Metabolic Syndrome', 'Metabolic Syndrome-associated-Sarcopenia', 'Glucose Intolerance-occurring-INS', 'Muscle Weakness-result-Obesity', 'INS-associated-Muscle Weakness', 'Muscle Weakness-associated-INS', 'INS-result-Obesity', 'INS-associated-Metabolic Syndrome', 'Metabolic Syndrome-associated-INS', 'Triglycerides-associated-Death', 'Death-associated-Triglycerides', 'KL-contribute-Hypertension', 'KL-contribute-Coronary Artery Disease', 'INS-measured-Memory Disorders', 'INS-measured-Dementia', 'Glucose-measured-Memory Disorders', 'Glucose-measured-Dementia', 'CRP-represent-Cardiovascular Diseases', 'Paraneoplastic Syndromes-characterized-Hypoglycemia', 'INS-administered-Diabetes Mellitus', 'Paraneoplastic Syndromes-characterized-Solitary Fibrous Tumors', 'TARDBP-associated-Alzheimer Disease', 'Alzheimer Disease-associated-TARDBP', 'Paraneoplastic Syndromes-secrete-IGF2', 'TARDBP-associated-Atrophy', 'Atrophy-associated-TARDBP', 'Solitary Fibrous Tumors-secrete-IGF2', 'Inflammation-compared-Infections', 'Inflammation-present-CRP', 'CRP-compared-Infections', 'Genetic Diseases, Inborn-caused-CTC1', 'Inflammation-influence-Psoriasis', 'Prediabetic State-influence-Psoriasis', 'CRP-influence-Psoriasis', 'Hypertrophy, Left Ventricular-predict-Hypertension', 'SIRT1-predict-Hypertrophy, Left Ventricular', 'SIRT1-predict-Hypertension', 'Epilepsy-associated-Fractures, Bone', 'Fractures, Bone-associated-Epilepsy', 'Fractures, Bone-associated-Topiramate', 'Topiramate-associated-Fractures, Bone', 'Heart Failure-associated-IGFBP7', 'IGFBP7-associated-Heart Failure', 'CRP-identify-Colorectal Neoplasms', 'IGFBP7-associated-Hypotension', 'Hypotension-associated-IGFBP7', 'Osteoarthritis-possess-Necrosis', 'MAPT-induce-Nerve Degeneration', 'Insulin Glargine-compare-Diabetes Mellitus', 'Insulin Glargine-compare-Cardiovascular Diseases', 'Breast Neoplasms-result-Heart Diseases', 'Anthracyclines-used-Breast Neoplasms', 'Anthracyclines-treat-Breast Neoplasms', 'Anthracyclines-used-Heart Diseases', 'Anthracyclines-result-Heart Diseases', 'JAK1-show-Arthritis, Rheumatoid', 'JAK1-show-Crohn Disease', 'Brain Injuries, Traumatic-differ-Alzheimer Disease', 'Brain Injuries, Traumatic-differ-MAPT', 'Renal Insufficiency, Chronic-associated-Inflammation', 'Inflammation-associated-Renal Insufficiency, Chronic', 'DIAPH1-localize-Lipid Metabolism Disorders', 'Renal Insufficiency, Chronic-associated-CRP', 'CRP-associated-Renal Insufficiency, Chronic', 'VEGFA-determined-Alzheimer Disease', 'VEGFA-determined-Dementia, Vascular', 'Liver Failure-predict-Death', 'GPT-serve-Liver Failure', 'GPT-predict-Death', 'Genetic Diseases, Inborn-associated-Hypertension', 'Hypertension-associated-Genetic Diseases, Inborn', 'Heart Diseases-emerge-Heart Failure', 'TTR-emerge-Heart Failure', 'Colorectal Neoplasms-include-Neoplasms', 'KL-identified-Neoplasms', 'KL-characterized-Neoplasms', 'KL-identified-Colorectal Neoplasms', 'KL-characterized-Colorectal Neoplasms', 'Acute Coronary Syndrome-treated-Cholesterol', 'Cardiomyopathy, Dilated-lead-Heart Failure', 'LMNA-lead-Heart Failure', 'Lung Neoplasms-reduce-CD4', 'Inflammation-associated-Obesity', 'Obesity-associated-Inflammation', 'Brain Diseases-known-Synucleinopathies', 'Obesity-associated-IL6', 'IL6-associated-Obesity', 'Bone Diseases, Metabolic-explain-Renal Insufficiency, Chronic', 'DCTN1-evoke-Tauopathies', 'Bone Diseases, Metabolic-explain-Cardiovascular Diseases', 'rs886039227-evoke-Tauopathies', 'KL-emerge-Bone Diseases, Metabolic', 'KL-explain-Renal Insufficiency, Chronic', 'KL-explain-Cardiovascular Diseases', 'ADIPOQ-associated-Weight Loss', 'Weight Loss-associated-ADIPOQ', 'Prostatic Neoplasms-treat-Neoplasms', 'Prostatic Neoplasms-inhibit-Neoplasms', 'Prostatic Neoplasms-treat-GADD45B', 'Prostatic Neoplasms-increase-GADD45B', 'GADD45B-inhibit-Neoplasms', 'MAPK9-identify-Atrial Remodeling', 'MAPK9-make-Atrial Remodeling', 'MAPK9-make-Atrial Fibrillation', 'CRP-related-Bone Marrow Diseases', 'Kearns-Sayre Syndrome-increase-ERBB2', 'CRP-related-Pleural Effusion', 'AMH-associated-Multiple Sclerosis', 'Multiple Sclerosis-associated-AMH', 'Ovarian Diseases-associated-Multiple Sclerosis', 'Multiple Sclerosis-associated-Ovarian Diseases', 'Arthritis, Rheumatoid-remain-Neoplasms', 'TNF-remain-Neoplasms', 'KL-associated-Leukoencephalopathies', 'Leukoencephalopathies-associated-KL', 'Sarcopenia-associated-Obesity', 'Obesity-associated-Sarcopenia', 'INS-associated-Obesity', 'Obesity-associated-INS', 'Inflammation-examine-Atherosclerosis', 'CRP-examine-Inflammation', 'Hypoglycemia-treated-gamma-Linolenic Acid', 'Weight Gain-treated-gamma-Linolenic Acid', 'Hypoglycemia-treated-Insulin Glargine', 'Weight Gain-treated-Insulin Glargine', 'INS-associated-Parkinson Disease', 'Parkinson Disease-associated-INS', 'Mucopolysaccharidosis III-characterized-Heparitin Sulfate', 'Lysosomal Storage Diseases-characterized-Heparitin Sulfate', 'KL-contribute-Sclerosis', 'KL-contribute-Multiple Sclerosis', 'MAPT-cause-Neurodegenerative Diseases', 'MAPT-cause-Dementia', 'TARDBP-considered-Atrophy', 'Obesity-lead-Weight Loss', 'Cardiovascular Diseases-associated-Heart Failure', 'Heart Failure-associated-Cardiovascular Diseases', 'LEP-lead-Weight Loss', 'Cardiovascular Diseases-associated-Dementia', 'Dementia-associated-Cardiovascular Diseases', 'Drug Overdose-overdose-Hemorrhage', 'Enoxaparin-overdose-Drug Overdose', 'Kidney Failure, Chronic-treated-Venous Thrombosis', 'Enoxaparin-decrease-Hemorrhage', 'Enoxaparin-treated-Venous Thrombosis', 'Renal Insufficiency, Chronic-include-Diabetes Mellitus, Type 2', 'Dementia-include-Diabetes Mellitus, Type 2', 'Neoplasms-associated-Heart Diseases', 'Heart Diseases-associated-Neoplasms', 'Brugada Syndrome-associated-Anthracyclines', 'Anthracyclines-associated-Brugada Syndrome', 'Neoplasms-associated-Anthracyclines', 'Anthracyclines-associated-Neoplasms', 'Paralysis-induced-PMP22', 'TARDBP-related-Sclerosis', 'Nervous System Diseases-distinguish-Retinal Degeneration', 'ALDH2-associated-Asthma', 'Asthma-associated-ALDH2', 'Nervous System Diseases-emphasize-Alzheimer Disease', 'ALDH2-associated-Pulmonary Disease, Chronic Obstructive', 'Pulmonary Disease, Chronic Obstructive-associated-ALDH2', 'Dementia-predict-Glucose Intolerance', 'Dementia-predict-Alzheimer Disease', 'Constipation-increase-Urinary Incontinence', 'Fractures, Bone-detect-Diabetes Mellitus, Type 2', 'Dementia-predict-Atherosclerosis', 'CRP-detect-Fractures, Bone', 'Constipation-decrease-Triglycerides', 'CRP-detect-Diabetes Mellitus, Type 2', 'Urinary Incontinence-decrease-Triglycerides', 'Cholesterol-predict-Dementia', 'Cholesterol-predict-Glucose Intolerance', 'Cholesterol-predict-Alzheimer Disease', 'Cholesterol-predict-Atherosclerosis', 'Carcinoma, Hepatocellular-develop-Fibrosis', 'Carcinoma, Hepatocellular-develop-Neoplasms', 'CCR5-reduce-Atherosclerosis', 'Hemophilia B-include-Hypoxia', 'CXCL8-include-Hypoxia', 'Glucose-include-Hypoxia', 'VEGFA-reported-Synovitis', 'Pulmonary Disease, Chronic Obstructive-combined-Cerebral Infarction', 'KL-linked-Osteoporosis', 'KL-linked-Sarcopenia', 'HIV Infections-associated-Death', 'Death-associated-HIV Infections', 'HIV Infections-associated-IL6', 'IL6-associated-HIV Infections', 'Neutropenia-receive-Bone Marrow Diseases', 'Neoplasms-receive-Bone Marrow Diseases', 'Inflammation-related-Coronary Artery Disease', 'TERC-improve-Inflammation', 'rs12696304-improve-Inflammation', 'HIV Infections-measured-IL6', 'Death-demonstrate-Stomach Neoplasms', 'Dyslipidemias-include-Coronary Artery Disease', 'Myotonic Dystrophy-include-Coronary Artery Disease', 'Stomach Neoplasms-associated-Epstein-Barr Virus Infections', 'Epstein-Barr Virus Infections-associated-Stomach Neoplasms', 'Coronary Artery Disease-associated-AMH', 'AMH-associated-Coronary Artery Disease', 'Progeria-caused-LMNA', 'Citrullinemia-caused-ASS1', 'Aging, Premature-caused-LMNA', 'Urea Cycle Disorders, Inborn-caused-ASS1', 'Hypogonadism-measure-KLK3', 'Infertility, Female-measure-KLK3', 'Metabolic Syndrome-base-Diabetes Mellitus', 'Metabolic Syndrome-base-INS', 'Huntington Disease-manifest-HTT', 'Heredodegenerative Disorders, Nervous System-manifest-HTT', 'Sleep Wake Disorders-associated-Alzheimer Disease', 'Alzheimer Disease-associated-Sleep Wake Disorders', 'TCF7L2-associated-Pancreatitis', 'Pancreatitis-associated-TCF7L2', 'APOE-associated-Alzheimer Disease', 'Alzheimer Disease-associated-APOE', 'TCF7L2-associated-Liver Failure', 'Liver Failure-associated-TCF7L2', 'TCF7L2-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-TCF7L2', 'rs7903146-associated-Pancreatitis', 'Pancreatitis-associated-rs7903146', 'rs7903146-associated-Liver Failure', 'Liver Failure-associated-rs7903146', 'rs7903146-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-rs7903146', 'Glucose-associated-Coma', 'Coma-associated-Glucose', 'MFN2-associated-Sarcopenia', 'Sarcopenia-associated-MFN2', 'Heart Failure-remain-Drug-Related Side Effects and Adverse Reactions', 'Digoxin-remain-Drug-Related Side Effects and Adverse Reactions', 'Death-related-Dementia', 'Denosumab-shown-Osteoporosis', 'Denosumab-shown-Bone Diseases', 'PRL-associated-Delirium', 'Delirium-associated-PRL', 'PRL-associated-Chiari-Frommel Syndrome', 'Chiari-Frommel Syndrome-associated-PRL', 'Crohn Disease-suggest-Infections', 'Crohn Disease-suggest-Skin Neoplasms', 'Glutathione-associated-Sleep Wake Disorders', 'Sleep Wake Disorders-associated-Glutathione', 'Crohn Disease-suggest-Lymphoma', 'Heart Failure-associated-EPO', 'EPO-associated-Heart Failure', 'Metabolic Syndrome-associated-Obesity, Abdominal', 'Obesity, Abdominal-associated-Metabolic Syndrome', 'Metabolic Syndrome-associated-Cholesterol', 'Cholesterol-associated-Metabolic Syndrome', 'EPO-associated-Death', 'Death-associated-EPO', 'RETN-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-RETN', 'RETN-associated-Metabolic Diseases', 'Metabolic Diseases-associated-RETN', 'RETN-attenuate-Inflammation', 'LBP-associated-Obesity', 'Obesity-associated-LBP', 'LBP-associated-Metabolic Diseases', 'Metabolic Diseases-associated-LBP', 'Heart Failure-caused-Amyloidosis', 'Heart Failure-caused-TTR', 'Glucose Metabolism Disorders-develop-INS', 'TMEM106B-identified-Frontotemporal Lobar Degeneration', 'TMEM106B-identified-Dementia', 'Fibrosis-associated-Carcinoma, Hepatocellular', 'Carcinoma, Hepatocellular-associated-Fibrosis', 'Metabolic Syndrome-increase-Cardiovascular Diseases', 'Fibrosis-associated-Hepatitis C', 'Hepatitis C-associated-Fibrosis', 'Metabolic Syndrome-include-Obesity', 'Metabolic Syndrome-include-Inflammation', 'Metabolic Syndrome-include-INS', 'Calcinosis-modulated-SPP1', 'LEP-associated-Death', 'Death-associated-LEP', 'LEP-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-LEP', 'Dementia-fit-Seizures', 'Dementia-affect-Alzheimer Disease', 'Seizures-affect-Alzheimer Disease', 'Seizures-mediate-APOE', 'Alzheimer Disease-mediate-APOE', 'LGR5-suggested-Neoplasms', 'LGR5-suggested-Colorectal Neoplasms', 'FXN-implicated-Friedreich Ataxia', 'PTX3-predict-Death', 'CST3-seem-Renal Insufficiency, Chronic', 'CST3-seem-Lupus Erythematosus, Systemic', 'LILRB1-associated-Joint Diseases', 'Joint Diseases-associated-LILRB1', 'IFNA1-associated-Neoplasms', 'Neoplasms-associated-IFNA1', 'IFNA1-associated-Prostatic Neoplasms', 'Prostatic Neoplasms-associated-IFNA1', 'IFNA1-play-Carcinogenesis', 'APOE-associated-Delirium', 'Delirium-associated-APOE', 'Metabolic Syndrome-associated-Glucose', 'Glucose-associated-Metabolic Syndrome', 'Deglutition Disorders-result-Death', 'Lisinopril-given-Deglutition Disorders', 'Lisinopril-result-Death', 'SIRT4-serve-Colorectal Neoplasms', 'Polyneuropathies-associated-Hypertension', 'Hypertension-associated-Polyneuropathies', 'ITLN1-associated-Cholesterol', 'Cholesterol-associated-ITLN1', 'ITLN1-associated-Polyneuropathies', 'Polyneuropathies-associated-ITLN1', 'ITLN1-associated-Hypertension', 'Hypertension-associated-ITLN1', 'Polyneuropathies-associated-Cholesterol', 'Cholesterol-associated-Polyneuropathies', 'rs104893877-induce-Neurodegenerative Diseases', 'rs104893877-induce-Synucleinopathies', 'Constipation-correlate-Olfaction Disorders', 'ITLN1-reduced-Polyneuropathies', 'Constipation-correlate-Parkinson Disease', 'Parkinson Disease-correlate-Olfaction Disorders', 'SNCA-correlate-Olfaction Disorders', 'SNCA-correlate-Parkinson Disease', 'rs11931074-correlate-Olfaction Disorders', 'rs11931074-correlate-Parkinson Disease', 'ACLY-associated-Neoplasms', 'Neoplasms-associated-ACLY', 'ACLY-correlate-Neoplasm Metastasis', 'POSTN-detected-Diabetes Mellitus', 'POSTN-detected-Albuminuria', 'Anemia-appear-Hypoalbuminemia', 'Anemia-appear-Malnutrition', 'Anemia-warrant-ALB', 'Hypoalbuminemia-warrant-ALB', 'Malnutrition-warrant-ALB', 'Inflammation-associated-TTR', 'TTR-associated-Inflammation', 'VEGFA-associated-Ossification of Posterior Longitudinal Ligament', 'Ossification of Posterior Longitudinal Ligament-associated-VEGFA', 'Tooth, Impacted-impact-White Dot Syndromes', 'Tooth, Impacted-impact-Lipofuscin', 'Malnutrition-associated-Death', 'Death-associated-Malnutrition', 'TTR-associated-Death', 'Death-associated-TTR', 'CRP-associated-Headache Disorders, Secondary', 'Headache Disorders, Secondary-associated-CRP', 'Lymphoma, B-Cell-cured-Anthracyclines', 'Lymphoma, B-Cell-cured-Rituximab', 'Diabetes Mellitus, Type 2-base-Glucose', 'Diabetes Mellitus, Type 2-classified-Glucose', 'INS-occur-Obesity', 'INS-occur-Diabetes Mellitus, Type 2', 'Death-caused-Infections', 'CD8A-contribute-Death', 'Leukopenia-accompanied-FGF2', 'Colonic Neoplasms-collected-Colorectal Neoplasms', 'Colonic Neoplasms-collected-SST', 'Colorectal Neoplasms-collected-SST', 'Cartilage Diseases-implicated-Osteoarthritis', 'Cartilage Diseases-associated-Osteoarthritis', 'Osteoarthritis-associated-Cartilage Diseases', 'HDAC4-implicated-Osteoarthritis', 'HDAC4-associated-Osteoarthritis', 'Osteoarthritis-associated-HDAC4', 'LEP-associated-Dementia', 'Dementia-associated-LEP', 'Prostaglandins-cause-Atrophy', 'Prostaglandins-lead-Eyelid Diseases', 'RECQL-contribute-Neoplasms', 'Prostaglandins-lead-Musculoskeletal Diseases', 'LCN2-become-Diabetic Nephropathies', 'LCN2-become-Diabetes Mellitus, Type 2', 'INS-proposed-Diabetes Mellitus', 'INS-determine-Cardiovascular Diseases', 'INS-proposed-Cardiovascular Diseases', 'Diabetes Mellitus-proposed-INS', 'Cardiovascular Diseases-proposed-INS', 'SAG-translate-Neoplasms', 'Retinal Diseases-examined-Diabetes Mellitus', 'Diabetes Mellitus-examined-INS', 'Retinal Diseases-examined-INS', 'INS-examined-Diabetes Mellitus', 'RPTOR-associated-Obesity', 'Obesity-associated-RPTOR', 'KL-related-Proteinuria', 'Heart Failure-increase-Glucose Intolerance', 'Heart Failure-increase-Diabetes Mellitus', 'Glucose-increase-Heart Failure', 'IGF1R-implicated-Carcinogenesis', 'IGF1R-implicated-Drug-Related Side Effects and Adverse Reactions', 'Nervous System Diseases-include-Atrophy', 'Metabolic Syndrome-associated-Inflammation', 'Inflammation-associated-Metabolic Syndrome', 'Diabetes Mellitus-defined-Hyperglycemia', 'Nervous System Diseases-include-Gentamicins', 'Hyperglycemia-result-Insulin Resistance', 'Hyperglycemia-defined-Insulin Resistance', 'Glucose-defined-Hyperglycemia', 'CST3-associated-Inflammation', 'Inflammation-associated-CST3', 'CRP-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-CRP', 'Insulin Resistance-result-Glucose', 'Calcinosis-modulate-Inflammation', 'Calcinosis-foster-Weight Gain', 'Inflammation-foster-Weight Gain', 'AHSG-contribute-Calcinosis', 'AHSG-modulate-Inflammation', 'AHSG-foster-Weight Gain', 'AVP-associated-Death', 'Death-associated-AVP', 'Osteoporosis-associated-Sarcopenia', 'Sarcopenia-associated-Osteoporosis', 'Neoplasms-analyzed-TERT', 'TERT-identified-Carcinoma, Hepatocellular', 'Carcinoma, Hepatocellular-analyzed-TERT', 'TERT-associated-Hepatitis C', 'Hepatitis C-associated-TERT', 'TERT-identified-Hepatitis C', 'Carcinoid Tumor-related-Vipoma', 'HIV Infections-cause-Inflammation', 'HIV Infections-contribute-Hypertriglyceridemia', 'Carcinoid Tumor-delay-Neoplasms', 'HIV Infections-contribute-Atherosclerosis', 'Sarcopenia-related-Death', 'Sarcopenia-compare-Death', 'Inflammation-contribute-Atherosclerosis', 'Carcinoid Tumor-delay-Neuroendocrine Tumors', 'Sarcopenia-related-H19', 'HIV Infections-cause-INS', 'Carcinoid Tumor-indicated-Neuroendocrine Tumors', 'Cholesterol-contribute-Atherosclerosis', 'Diarrhea-delay-Neoplasms', 'Diarrhea-delay-Neuroendocrine Tumors', 'Hemorrhage-evolve-von Willebrand Diseases', 'VWF-evolve-von Willebrand Diseases', 'Vipoma-delay-Neoplasms', 'MAP2K4-establish-Atrial Fibrillation', 'MAP2K4-treat-Atrial Fibrillation', 'Vipoma-delay-Neuroendocrine Tumors', 'Vipoma-indicated-Neuroendocrine Tumors', 'Neoplasms-delay-Neuroendocrine Tumors', 'Nerve Degeneration-subdivided-Dementia', 'Octreotide-indicated-Carcinoid Tumor', 'ALB-subdivided-Dementia', 'Octreotide-indicated-Diarrhea', 'Octreotide-indicated-Vipoma', 'Octreotide-delay-Neoplasms', 'Octreotide-delay-Neuroendocrine Tumors', 'Hyperglycemia-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-Hyperglycemia', 'Hyperglycemia-associated-INS', 'INS-associated-Hyperglycemia', 'Prediabetic State-enrol-Glucose', 'Diabetes Mellitus-increase-Glucose Metabolism Disorders', 'Diabetes Mellitus-increase-Diabetes Mellitus, Type 2', 'Diabetes Mellitus-increase-Glucose', 'Non-alcoholic Fatty Liver Disease-associate-Hyperhomocysteinemia', 'Hyperhomocysteinemia-associate-Non-alcoholic Fatty Liver Disease', 'Non-alcoholic Fatty Liver Disease-associate-rs1801131', 'rs1801131-associate-Non-alcoholic Fatty Liver Disease', 'Diabetes Mellitus-suggest-Hypotension', 'Diabetes Mellitus-suggest-Glucose', 'TNFRSF11B-correlated-Kidney Failure, Chronic', 'TNFRSF11B-correlated-Diabetes Mellitus', 'PRL-associated-Metabolic Syndrome', 'Metabolic Syndrome-associated-PRL', 'PRL-associated-Erectile Dysfunction', 'Erectile Dysfunction-associated-PRL', 'Glucose Metabolism Disorders-base-Diabetes Mellitus', 'Glucose Metabolism Disorders-base-Glucose', 'Glucose-base-Diabetes Mellitus', 'Alzheimer Disease-include-Glucose', 'Inflammation-associated-Dyslipidemias', 'Dyslipidemias-associated-Inflammation', 'Arthralgia-imaged-Infections', 'Arthralgia-included-Fluorodeoxyglucose F18', 'Fluorodeoxyglucose F18-imaged-Infections', 'Hepatitis C-show-Carcinoma, Hepatocellular', 'COL18A1-involved-Cardiovascular Diseases', 'COL18A1-involved-Neoplasms', 'INS-believed-Metabolic Syndrome', 'INS-believed-Diabetes Mellitus, Type 2', 'Death-estimate-rs13038305', 'Cardiovascular Diseases-estimate-rs13038305', 'INS-play-Alzheimer Disease', 'Alzheimer Disease-undergo-Death', 'Hyperglycemia-undergo-Death', 'Hyperinsulinism-undergo-Death', 'Glucose Intolerance-undergo-Death', 'INS-undergo-Death', 'Fish Oils-attenuate-Sick Sinus Syndrome', 'Hypoglycemia-require-Diabetes Mellitus', 'Diabetes Mellitus-treat-Glucose', 'Glucose-undergo-Death', 'Glucose-treat-Diabetes Mellitus', 'Stroke-increase-Death', 'Infections-increase-Stroke', 'Pneumonia-increase-Stroke', 'Pneumonia-increase-Death', 'Stroke-increase-IL6', 'Death-increase-IL6', 'Metabolic Diseases-promote-Cerebrovascular Disorders', 'Metabolic Diseases-promote-IAPP', 'Inflammation-occur-Metabolic Diseases', 'Pancreatitis-cause-Diabetes Mellitus', 'Inflammation-occur-Obesity', 'Inflammation-linked-Obesity', 'IAPP-cause-Diabetes Mellitus', 'Inflammation-occur-Diabetes Mellitus', 'Inflammation-linked-Diabetes Mellitus', 'KL-linked-Inflammation', 'Weight Loss-reduce-Cardiovascular Diseases', 'Ascorbic Acid-associated-Heart Failure', 'Heart Failure-associated-Ascorbic Acid', 'Weight Loss-reduce-LEP', 'KL-occur-Metabolic Diseases', 'Ascorbic Acid-associated-Myocardial Infarction', 'Myocardial Infarction-associated-Ascorbic Acid', 'LEP-reduce-Cardiovascular Diseases', 'KL-occur-Obesity', 'KL-occur-Diabetes Mellitus', 'C9orf72-underlie-Dementia', 'C9orf72-underlie-Amyotrophic Lateral Sclerosis', 'APOE-modify-Hypertension', 'APOE-modify-Cardiovascular Diseases', 'APOE-modify-Diabetes Mellitus', 'Alzheimer Disease-screen-Dementia', 'C9orf72-explain-Alzheimer Disease', 'C9orf72-screen-Dementia', 'CADASIL-caused-NOTCH3', 'Leukoencephalopathies-caused-NOTCH3', 'Cerebral Small Vessel Diseases-caused-NOTCH3', 'Atherosclerosis-lead-Mitochondrial Diseases', 'INS-lead-Atherosclerosis', 'INS-lead-Mitochondrial Diseases', 'Diabetes Mellitus-predict-Death', 'ADIPOQ-predict-Diabetes Mellitus', 'LPA-associated-Aortic Valve Stenosis', 'Aortic Valve Stenosis-associated-LPA', 'Genetic Diseases, Inborn-encode-SLC12A3', 'ADIPOQ-demonstrate-Obesity', 'ADIPOQ-demonstrate-Diabetes Mellitus', 'ADIPOQ-demonstrate-Cardiovascular Diseases', 'Neoplasms-undergo-Colorectal Neoplasms', 'Metabolic Syndrome-shown-Obesity', 'Metabolic Syndrome-shown-Hypertension', 'Metabolic Syndrome-include-Hypertension', 'Metabolic Syndrome-shown-Dyslipidemias', 'Metabolic Syndrome-include-Dyslipidemias', 'Obesity-include-Metabolic Syndrome', 'Obesity-shown-Metabolic Syndrome', 'Hypertension-include-Metabolic Syndrome', 'Hypertension-shown-Metabolic Syndrome', 'Dyslipidemias-include-Metabolic Syndrome', 'Dyslipidemias-shown-Metabolic Syndrome', 'Metabolic Syndrome-shown-INS', 'INS-include-Metabolic Syndrome', 'INS-shown-Metabolic Syndrome', 'Anemia-refuse-Parkinson Disease', 'EPO-increase-Anemia', 'Dyslipidemias-increase-Cardiovascular Diseases', 'Lipodystrophy-increase-Cardiovascular Diseases', 'Octreotide-considered-Poisoning', 'Octreotide-considered-Hypoglycemia', 'Hypertension-recorded-Octreotide', 'Apnea-recorded-Octreotide', 'Chronic Disease-contribute-Obesity', 'Chronic Disease-contribute-Hypertension', 'Chronic Disease-contribute-Stroke', 'Hypertension-include-Obesity', 'Stroke-include-Obesity', 'Death-include-Obesity', 'Genetic Diseases, Inborn-induce-Epilepsy', 'Chronic Disease-contribute-INS', 'Hypertension-include-INS', 'Stroke-include-INS', 'HCN1-induce-Genetic Diseases, Inborn', 'Death-include-INS', 'HCN1-induce-Epilepsy', 'Inflammation-predict-Death', 'Inflammation-predict-Pulmonary Disease, Chronic Obstructive', 'Bone Diseases, Metabolic-founded-Hypocalcemia', 'Bone Diseases, Metabolic-founded-PTH', 'Ghrelin-elevated-Metabolic Syndrome', 'Ghrelin-bear-Metabolic Syndrome', 'Ceramides-associated-Memory Disorders', 'Memory Disorders-associated-Ceramides', 'CTTN-predict-Prostatic Neoplasms', 'RORA-contribute-Emphysema', 'Fatty Acids, Unsaturated-protect-Dementia', 'LEP-associated-Obesity, Abdominal', 'Obesity, Abdominal-associated-LEP', 'LEP-display-Diabetes Mellitus, Type 2', 'Glucose-display-Diabetes Mellitus, Type 2', 'CRP-emerge-Cardiovascular Diseases', 'CRP-emerge-Inflammation', 'Arthritis, Rheumatoid-remain-Alemtuzumab', 'Metabolic Diseases-associate-AIDS Arteritis, Central Nervous System', 'AIDS Arteritis, Central Nervous System-associate-Metabolic Diseases', 'Blood Glucose-associate-AIDS Arteritis, Central Nervous System', 'AIDS Arteritis, Central Nervous System-associate-Blood Glucose', 'MAPT-differentiate-Alzheimer Disease', 'ACE-associated-Death', 'Death-associated-ACE', 'ACE-associated-Atherosclerosis', 'Atherosclerosis-associated-ACE', 'ACE-associated-Hypertension', 'Hypertension-associated-ACE', 'ACE-associated-Myocardial Infarction', 'Myocardial Infarction-associated-ACE', 'Hypothyroidism-persist-Euthyroid Sick Syndromes', 'Hypothyroidism-persist-Thyrotropin', 'Hypothermia-reduce-Surgical Wound Infection', 'Glucose-reduce-Surgical Wound Infection', 'Diabetes Mellitus, Type 2-associated-Fibrosis', 'Fibrosis-associated-Diabetes Mellitus, Type 2', 'Diabetes Mellitus, Type 2-associated-Cerebrovascular Disorders', 'Cerebrovascular Disorders-associated-Diabetes Mellitus, Type 2', 'Diabetes Mellitus, Type 2-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-Diabetes Mellitus, Type 2', 'Diabetes Mellitus, Type 2-associated-INS', 'INS-associated-Diabetes Mellitus, Type 2', 'Breast Neoplasms-include-Neoplasms', 'CCND1-play-Neoplasms', 'CCND1-play-Breast Neoplasms', 'H19-associated-Metabolic Diseases', 'Metabolic Diseases-associated-H19', 'Hypertension-associated-IGF1', 'IGF1-associated-Hypertension', 'Dyslipidemias-associated-IGF1', 'IGF1-associated-Dyslipidemias', 'Diabetes Mellitus-associated-IGF1', 'IGF1-associated-Diabetes Mellitus', 'Coronary Artery Disease-associated-IGF1', 'IGF1-associated-Coronary Artery Disease', 'ACE-treat-Hypertension', 'GPT-measured-Diabetes Mellitus, Type 2', 'GPT-measured-Diabetes Mellitus', 'Neoplasms-determine-Carcinoma, Hepatocellular', 'AFP-determine-Carcinoma, Hepatocellular', 'Glucose-investigate-Death', 'Inflammation-affect-Chronic Disease', 'INS-affect-Chronic Disease', 'Melkersson-Rosenthal Syndrome-associated-Alzheimer Disease', 'Alzheimer Disease-associated-Melkersson-Rosenthal Syndrome', 'Inositol-associated-Alzheimer Disease', 'Alzheimer Disease-associated-Inositol', 'Heart Failure-result-Fibrosis', 'Obesity-determine-Inflammation', 'Tinzaparin-receive-Venous Thromboembolism', 'Heart Diseases-treated-Trastuzumab', 'Diabetes Mellitus-treated-Trastuzumab', 'Heart Failure-characterize-NPPA', 'PTH-associated-Hip Fractures', 'Hip Fractures-associated-PTH', 'Amyloidosis-characterize-NPPA', 'APOE-accelerate-HIV Infections', 'Hyperglycemia-include-Diabetes Mellitus', 'Hyperinsulinism-include-Diabetes Mellitus', 'INS-include-Diabetes Mellitus', 'Acute Coronary Syndrome-receive-Glucose', 'Death-provide-Heart Failure', 'RBP4-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-RBP4', 'RBP4-associated-Metabolic Syndrome', 'Metabolic Syndrome-associated-RBP4', 'Glioma-related-VEGFA', 'EGFR-tend-Neoplasms', 'EGFR-tend-Drug-Related Side Effects and Adverse Reactions', 'Hypertension-identified-Lupus Erythematosus, Systemic', 'Digoxin-control-Heart Failure', 'Digoxin-control-Atrial Fibrillation', 'GSTM1-associated-Death', 'Death-associated-GSTM1', 'GSTM1-associated-Inflammation', 'Inflammation-associated-GSTM1', 'Cyclosporine-proving-Inflammation', 'Cyclosporine-proving-Asthma', 'Cyclosporine-proving-Muscular Dystrophies', 'Coronary Artery Disease-include-Chronic Disease', 'CRP-associated-Chronic Disease', 'Chronic Disease-associated-CRP', 'CRP-associated-Coronary Artery Disease', 'Coronary Artery Disease-associated-CRP', 'Dementia-carry-APOE', 'Alzheimer Disease-carry-APOE', 'Metabolic Syndrome-support-Death', 'Glucose-potentiate-Death', 'Glucose-support-Metabolic Syndrome', 'Genetic Diseases, Inborn-caused-rs1346044', 'Diabetes Mellitus-occur-Obesity', 'Diabetes Mellitus-occur-INS', 'Arthritis, Rheumatoid-treated-TNF', 'Diabetes Mellitus-exhibit-INS', 'Polycystic Ovary Syndrome-decrease-INS', 'Metabolic Syndrome-comprise-Obesity', 'Metabolic Syndrome-comprise-Hypertension', 'Metabolic Syndrome-comprise-Dyslipidemias', 'Metabolic Syndrome-comprise-Diabetes Mellitus', 'Metabolic Syndrome-comprise-Cardiovascular Diseases', 'Metabolic Syndrome-comprise-INS', 'INS-associated-Metabolic Diseases', 'Metabolic Diseases-associated-INS', 'Hyperparathyroidism-include-Parathyroid Neoplasms', 'PTH-distinguish-Parathyroid Neoplasms', 'PTH-distinguish-Hyperparathyroidism', 'KL-observed-Neoplasms', 'KL-observed-Neoplasm Invasiveness', 'Dementia-demonstrate-S100B', 'Delirium-demonstrate-S100B', 'GH1-use-Huntington Disease', 'Progeria-caused-ZMPSTE24', 'H19-associated-Metabolic Syndrome', 'Metabolic Syndrome-associated-H19', 'Genetic Diseases, Inborn-caused-ZMPSTE24', 'Cardiovascular Diseases-increase-Diabetes Mellitus', 'Cardiovascular Diseases-increase-Cholesterol', 'APOE-linked-Alzheimer Disease', 'INS-associated-Coronary Artery Disease', 'Coronary Artery Disease-associated-INS', 'INS-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-INS', 'AMH-increased-Ovarian Diseases', 'MAT1A-examined-Hypertension', 'MAT1A-examined-Stroke', 'MAT1A-examined-Cardiovascular Diseases', 'CST3-assess-Kidney Diseases', 'CST3-assess-Death', 'Hypertension-associated-MTHFR', 'MTHFR-associated-Hypertension', 'Stroke-associated-MTHFR', 'MTHFR-associated-Stroke', 'Death-compare-INS', 'Stroke-compare-INS', 'Arthritis, Rheumatoid-genotyped-rs10818488', 'Arthritis-genotyped-rs10818488', 'MAT1A-associated-Hypertension', 'Hypertension-associated-MAT1A', 'MAT1A-associated-Stroke', 'Stroke-associated-MAT1A', 'rs5882-associated-Dementia', 'Dementia-associated-rs5882', 'rs5882-associated-Alzheimer Disease', 'Alzheimer Disease-associated-rs5882', 'Death-associated-Multiple Organ Failure', 'Multiple Organ Failure-associated-Death', 'Metabolic Syndrome-predispose-Cardiovascular Diseases', 'Death-associated-Dementia', 'Dementia-associated-Death', 'Alzheimer Disease-associated-Dementia', 'Dementia-associated-Alzheimer Disease', 'Alzheimer Disease-precede-Dementia', 'Death-associated-Pneumonia', 'Pneumonia-associated-Death', 'Diabetes Mellitus-predispose-Cardiovascular Diseases', 'APOE-precede-Dementia', 'INS-predispose-Cardiovascular Diseases', 'Cholesterol-associated-Multiple Organ Failure', 'Multiple Organ Failure-associated-Cholesterol', 'Cholesterol-associated-Dementia', 'Dementia-associated-Cholesterol', 'Cholesterol-associated-Pneumonia', 'Pneumonia-associated-Cholesterol', 'Cholesterol-associated-Sepsis', 'Sepsis-associated-Cholesterol', 'Cholesterol-associated-Neoplasms', 'Neoplasms-associated-Cholesterol', 'INS-associated-Carcinoma, Hepatocellular', 'Carcinoma, Hepatocellular-associated-INS', 'Alcoholism-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-Alcoholism', 'Alcoholism-associated-CD4', 'CD4-associated-Alcoholism', 'LEP-relate-Dementia', 'Obesity-accumulate-Triglycerides', 'Diabetes Mellitus-accumulate-Triglycerides', 'LEP-associated-Alzheimer Disease', 'Alzheimer Disease-associated-LEP', 'Dementia-associated-Agnosia', 'Agnosia-associated-Dementia', 'Alzheimer Disease-associated-Agnosia', 'Agnosia-associated-Alzheimer Disease', 'Retinal Vein Occlusion-reported-Bevacizumab', 'APOE-associated-Agnosia', 'Agnosia-associated-APOE', 'Aneurysm-reported-Bevacizumab', 'Glucose-include-Metabolic Syndrome', 'Retinal Vein Occlusion-cause-Hypotension', 'Retinal Vein Occlusion-cause-Bevacizumab', 'Bevacizumab-cause-Hypotension', 'Ischemia-delay-Subarachnoid Hemorrhage', 'Ischemia-reduce-Subarachnoid Hemorrhage', 'EPO-reduce-Vasospasm, Intracranial', 'EPO-reduce-Subarachnoid Hemorrhage', 'Sepsis-obtain-Vasospasm, Intracranial', 'Sepsis-obtain-EPO', 'EPO-obtain-Vasospasm, Intracranial', 'Alzheimer Disease-undergo-MAPT', 'Fructose-increased-Diabetes Mellitus', 'Fructose-increased-Myocardial Infarction', 'INS-defined-Heart Failure', 'Hypotension, Orthostatic-compare-Prostaglandins', 'Diabetes Mellitus-associated-Alzheimer Disease', 'Alzheimer Disease-associated-Diabetes Mellitus', 'Cholesterol-associated-Alzheimer Disease', 'Alzheimer Disease-associated-Cholesterol', 'INS-influence-Polycystic Ovary Syndrome', 'Glucose Intolerance-performed-Hypertension', 'Glucose-performed-Hypertension', 'Dementia-Establish-Alzheimer Disease', 'GBA-assessed-Dementia', 'Obesity-mediate-Vascular System Injuries', 'Diabetes Mellitus-recognized-Cardiovascular Diseases', 'Hypertension-recognized-Cardiovascular Diseases', 'INS-recognized-Cardiovascular Diseases', 'Death-predicted-Diabetes Mellitus', 'Metabolic Syndrome-include-Obesity, Abdominal', 'Metabolic Syndrome-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-Metabolic Syndrome', 'Fructose-increased-Cataract', 'Metabolic Syndrome-associated-Cerebrovascular Disorders', 'Cerebrovascular Disorders-associated-Metabolic Syndrome', 'IGF1-associated-Death', 'Death-associated-IGF1', 'IGF1-cause-Death', 'IGF1-associated-Heart Failure', 'Heart Failure-associated-IGF1', 'IGF1-cause-Heart Failure', 'IGF1-observed-Cardiovascular Diseases', 'Diabetes Mellitus-exposed-Hypoxia', 'Fructose-induce-Cataract', 'Streptozocin-exposed-Hypoxia', 'Hypertension-treated-Atorvastatin', 'Kidney Diseases-associated-Calcinosis', 'Calcinosis-associated-Kidney Diseases', 'Hyperlipoproteinemia Type II-treated-Atorvastatin', 'CST3-associated-Calcinosis', 'Calcinosis-associated-CST3', 'Seizures-associated-CRP', 'CRP-associated-Seizures', 'Hereditary Breast and Ovarian Cancer Syndrome-reach-KLK3', 'Prostatic Neoplasms-reach-KLK3', 'Fat Necrosis-differ-Seizures', 'Fat Necrosis-differ-Inflammation', 'Obesity-associated-CRP', 'CRP-associated-Obesity', 'Seizures-differ-Inflammation', 'Fat Necrosis-differ-CRP', 'Fat Necrosis-associated-CRP', 'CRP-associated-Fat Necrosis', 'CRP-differ-Seizures', 'CRP-differ-Inflammation', 'Obesity-associated-Chronic Disease', 'Chronic Disease-associated-Obesity', 'Metabolic Syndrome-associated-APOE', 'APOE-associated-Metabolic Syndrome', 'Obesity-associated-Cholesterol', 'Cholesterol-associated-Obesity', 'CYP19A1-expressed-Osteoarthritis', 'CYP19A1-expressed-Hip Fractures', 'Heart Failure-include-Cardiovascular Diseases', 'Metabolic Syndrome-relate-Cardiovascular Diseases', 'Metabolic Syndrome-relate-Diabetes Mellitus, Type 2', 'Metabolic Syndrome-relate-Diabetes Mellitus', 'Metabolic Syndrome-relate-Cholesterol', 'Spinal Cord Injuries-associated-Bone Neoplasms', 'Bone Neoplasms-associated-Spinal Cord Injuries', 'Spinal Cord Injuries-place-Bone Neoplasms', 'Spinal Cord Injuries-associated-TNFRSF11B', 'TNFRSF11B-associated-Spinal Cord Injuries', 'TNFRSF11B-place-Bone Neoplasms', 'Inflammation-associated-INS', 'INS-associated-Inflammation', 'Autoimmune Diseases-represent-Primary Ovarian Insufficiency', 'Hypothalamic Neoplasms-indicate-SHBG', 'Obesity, Abdominal-dysregulate-Fatty Acids', 'Diabetes Mellitus-thought-INS', 'Octreotide-evaluate-Hyperinsulinism', 'Inflammation-confoun-Death', 'ADIPOQ-associated-Metabolic Syndrome', 'Metabolic Syndrome-associated-ADIPOQ', 'Inflammation-confoun-ALB', 'Octreotide-used-Hyperinsulinism', 'Immunologic Deficiency Syndromes-involved-Neurodegenerative Diseases', 'Immunologic Deficiency Syndromes-involved-Alzheimer Disease', 'Coronary Artery Disease-observed-Cardiovascular Diseases', 'Death-observed-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-Metabolic Syndrome', 'Metabolic Syndrome-associated-Cardiovascular Diseases', 'CRP-associated-Metabolic Syndrome', 'Metabolic Syndrome-associated-CRP', 'Coronary Artery Disease-assess-Cholesterol', 'Death-assess-Cholesterol', 'Hearing Loss-hear-Tinnitus', 'Atorvastatin-hear-Hearing Loss', 'Atorvastatin-result-Tinnitus', 'PON1-suffer-Cataract', 'PON1-evaluate-Diabetes Mellitus', 'INS-lead-Diabetes Mellitus', 'Heart Failure-improve-Muscular Atrophy', 'INS-lead-Coronary Artery Disease', 'Pulmonary Disease, Chronic Obstructive-improve-Muscular Atrophy', 'Ghrelin-improve-Muscular Atrophy', 'Death-suspect-Coronary Artery Disease', 'CRP-related-Death', 'CRP-related-Coronary Artery Disease', 'CRP-related-Myocardial Infarction', 'CRP-related-Stroke', 'CRP-related-Cerebral Infarction', 'Calcitriol-decrease-Cardiac Output, Low', 'Calcitriol-decrease-Renal Insufficiency', 'Primary Ovarian Insufficiency-associated-Turner Syndrome', 'Turner Syndrome-associated-Primary Ovarian Insufficiency', 'PLAU-diagnosed-Carcinoma, Non-Small-Cell Lung', 'KLK3-determined-Prostatic Neoplasms', 'INS-compare-Primary Ovarian Insufficiency', 'Breast Neoplasms-show-Neoplasms', 'INS-compare-Turner Syndrome', 'Cerebrovascular Disorders-vary-APOE', 'Breast Neoplasms-show-TP53', 'KL-proposed-Cardiovascular Diseases', 'KL-proposed-Glucose Metabolism Disorders', 'Glaucoma, Open-Angle-develop-Tooth Erosion', 'Glaucoma, Open-Angle-develop-Latanoprost', 'Small Fiber Neuropathy-associated-Pain', 'Pain-associated-Small Fiber Neuropathy', 'Hypertension-affect-INS', 'Diabetes Mellitus-associated-Pain', 'Pain-associated-Diabetes Mellitus', 'Obesity-associated-Pain', 'Pain-associated-Obesity', 'INS-associated-Pain', 'Pain-associated-INS', 'Acute Coronary Syndrome-associated-Atherosclerosis', 'Atherosclerosis-associated-Acute Coronary Syndrome', 'Cardiovascular Diseases-emerging-Inflammation', 'CRP-emerging-Cardiovascular Diseases', 'Leukemia, Myelogenous, Chronic, BCR-ABL Positive-assess-Liver Failure', 'CRP-emerging-Inflammation', 'AGER-assess-Liver Failure', 'APOE-represent-Dementia', 'Obesity-associated-Prostatic Hyperplasia', 'Prostatic Hyperplasia-associated-Obesity', 'Diabetes Mellitus-associated-Prostatic Hyperplasia', 'Prostatic Hyperplasia-associated-Diabetes Mellitus', 'Glucose-associated-Prostatic Hyperplasia', 'Prostatic Hyperplasia-associated-Glucose', 'Atherosclerosis-randomized-ACE', 'Erectile Dysfunction-randomized-ACE', 'Seizures-continue-Obesity, Abdominal', 'Seizures-continue-INS', 'INS-continue-Obesity, Abdominal', 'APOE-predict-Alzheimer Disease', 'Glucose Metabolism Disorders-occur-Obesity', 'Stomach Neoplasms-investigated-S100A8', 'Ulcer-investigated-S100A8', 'Gout-associated-Musculoskeletal Diseases', 'Musculoskeletal Diseases-associated-Gout', 'Coronary Artery Disease-associated-Musculoskeletal Diseases', 'Musculoskeletal Diseases-associated-Coronary Artery Disease', 'Triglycerides-associated-Musculoskeletal Diseases', 'Musculoskeletal Diseases-associated-Triglycerides', 'Heart Failure-receive-ACE', 'Infections-cause-TFF2', 'Ventricular Dysfunction, Left-receive-ACE', 'Sleep Deprivation-cause-TFF2', 'Myocardial Infarction-receive-ACE', 'IL6-associated-Osteoporosis', 'Osteoporosis-associated-IL6', 'IL6-associated-Sarcopenia', 'Sarcopenia-associated-IL6', 'Fatty Acids, Omega-3-associated-Alzheimer Disease', 'Alzheimer Disease-associated-Fatty Acids, Omega-3', 'Fatty Acids, Omega-3-associated-Stroke', 'Stroke-associated-Fatty Acids, Omega-3', 'Weight Loss-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-Weight Loss', 'Weight Loss-associated-Cholesterol', 'Cholesterol-associated-Weight Loss', 'Hyperbilirubinemia-complicated-Jaundice, Chronic Idiopathic', 'ABCC2-complicated-rs777902199', 'Hyperbilirubinemia-complicated-ABCC2', 'Jaundice, Chronic Idiopathic-complicated-ABCC2', 'Neoplasms-result-Small Cell Lung Carcinoma', 'Hyperbilirubinemia-remain-rs777902199', 'Jaundice, Chronic Idiopathic-remain-rs777902199', 'Neoplasms-result-Etoposide', 'Etoposide-result-Small Cell Lung Carcinoma', 'Lung Injury-follow-Neoplasms', 'ACE-affect-Lung Injury', 'Death-lowering-Cholesterol', 'Neoplasms-lowering-Cholesterol', 'Atherosclerosis-reflect-Diabetes Mellitus', 'N-Acetylneuraminic Acid-reflect-Atherosclerosis', 'N-Acetylneuraminic Acid-reflect-Diabetes Mellitus', 'N-Acetylneuraminic Acid-affect-Atherosclerosis', 'N-Acetylneuraminic Acid-affect-Diabetes Mellitus', 'ADIPOQ-contribute-Atherosclerosis', 'IL1RN-associated-Surgical Wound Infection', 'Surgical Wound Infection-associated-IL1RN', 'ADIPOQ-contribute-Progeria', 'Coronary Artery Disease-associated-NOS3', 'NOS3-associated-Coronary Artery Disease', 'Cholesterol-contribute-Progeria', 'Psychomotor Disorders-serve-Cardiovascular Diseases', 'Psychomotor Disorders-serve-MAOA', 'Lung Neoplasms-relate-QRSL1', 'Non-alcoholic Fatty Liver Disease-linked-Metabolic Syndrome', 'Non-alcoholic Fatty Liver Disease-linked-INS', 'APOE-related-Alzheimer Disease', 'MAPT-related-Glucose Metabolism Disorders', 'IBSP-based-Calcinosis', 'Glucose Intolerance-followed-Glucose', 'CRP-found-Infections', 'Diabetes Mellitus, Type 2-followed-Glucose', 'Diabetes Mellitus-followed-Glucose', 'CRP-found-Delirium', 'CRP-found-Cardiovascular Diseases', 'Diabetes Mellitus-take-INS', 'Stroke-take-INS', 'Death-take-INS', 'Crohn Disease-increased-Inflammation', 'Crohn Disease-decrease-Infliximab', 'Inflammation-decrease-Infliximab', 'Colonic Neoplasms-obtained-Crohn Disease', 'Colonic Neoplasms-obtained-Infliximab', 'Hepatitis C-associated-Cholesterol', 'Cholesterol-associated-Hepatitis C', 'HGF-reflect-Carotid Artery Diseases', 'HGF-influence-Carotid Artery Diseases', 'VDR-associated-Prostatic Hyperplasia', 'Prostatic Hyperplasia-associated-VDR', 'VDR-associated-Prostatic Neoplasms', 'Prostatic Neoplasms-associated-VDR', 'Dyslipidemias-associated-Obesity', 'Obesity-associated-Dyslipidemias', 'Erectile Dysfunction-contribute-Aneurysm', 'RHOA-contribute-Erectile Dysfunction', 'RHOA-contribute-Aneurysm', 'Diabetes Mellitus-harbor-Mitochondrial Encephalomyopathies', 'Diabetes Mellitus-harbor-Acidosis, Lactic', 'Cyclosporine-associated-Psychomotor Disorders', 'Psychomotor Disorders-associated-Cyclosporine', 'Cyclosporine-associated-Intellectual Disability', 'Intellectual Disability-associated-Cyclosporine', 'Cholesterol-increase-Myositis', 'Cholesterol-increase-Rhabdomyolysis', 'Cholesterol-increase-Neoplasms', 'Hypertension-predict-Atherosclerosis', 'INS-contribute-Metabolic Syndrome', 'VIP-assayed-Heart Failure', 'VIP-assayed-Cardiomyopathy, Dilated', 'CCND2-identified-Adenocarcinoma', 'Stroke-present-Infarction', 'ELN-test-Cerebrovascular Disorders', 'ELN-associated-Coronary Artery Disease', 'Coronary Artery Disease-associated-ELN', 'AVP-involved-Hyponatremia', 'AVP-involved-Adrenal Insufficiency', 'AVP-become-Hyponatremia', 'Venous Thrombosis-undergo-Hip Fractures', 'Pulmonary Embolism-undergo-Hip Fractures', 'Kidney Diseases-restored-Proteinuria', 'Heparin-undergo-Hip Fractures', 'Glomerulosclerosis, Focal Segmental-restored-Proteinuria', 'Nephrotic Syndrome-restored-Proteinuria', 'CLU-reduced-Kidney Diseases', 'Obesity, Abdominal-correlate-Glucose Intolerance', 'CLU-reduced-Glomerulosclerosis, Focal Segmental', 'Obesity, Abdominal-correlate-Glucose', 'CLU-reduced-Nephrotic Syndrome', 'CLU-restored-Proteinuria', 'Tramadol-tolerate-Osteoarthritis', 'Tramadol-tolerate-Pain', 'Cholesterol-associated-Body Weight Changes', 'Body Weight Changes-associated-Cholesterol', 'NGF-compared-Dementia', 'Acidosis, Lactic-produce-Pyruvate Carboxylase Deficiency Disease', 'Atherosclerosis-associated-Cerebral Amyloid Angiopathy', 'Cerebral Amyloid Angiopathy-associated-Atherosclerosis', 'PON1-associated-Cerebral Amyloid Angiopathy', 'Cerebral Amyloid Angiopathy-associated-PON1', 'AGER-prime-Atherosclerosis', 'AGER-prime-Inflammation', 'ACE-halt-Hypertension', 'Cholesterol-recorded-Coronary Artery Disease', 'Cholesterol-recorded-Death', 'Coronary Artery Disease-associated-Death', 'Death-associated-Coronary Artery Disease', 'Coronary Artery Disease-associated-Cholesterol', 'Cholesterol-associated-Coronary Artery Disease', 'Trastuzumab-overexpressed-Neoplasms', 'Trastuzumab-overexpressed-Breast Neoplasms', 'Fractures, Bone-reflect-CYP27A1', 'Hip Fractures-reflect-CYP27A1', 'Valproic Acid-exclude-Epilepsy', 'HFE-associated-Hemochromatosis', 'Hemochromatosis-associated-HFE', 'HFE-associated-Death', 'Death-associated-HFE', 'MAPT-determined-Alzheimer Disease', 'Glucose-affected-Alzheimer Disease', 'Alzheimer Disease-increased-Parkinson Disease', 'MAPT-increased-Alzheimer Disease', 'MAPT-increased-Parkinson Disease', 'Hypertension-compared-Glucose', 'Endometrial Neoplasms-arise-Muscular Disorders, Atrophic', 'EREG-correlate-Endometrial Neoplasms', 'EREG-determine-Endometrial Neoplasms', 'EREG-correlate-Muscular Disorders, Atrophic', 'Death-identify-Cardiovascular Diseases', 'Diabetes Mellitus, Type 2-mimic-Obesity', 'Diabetes Mellitus, Type 2-contribute-INS', 'Hyperglycemia-recognized-Cardiovascular Diseases', 'INS-contribute-Obesity', 'Hyperglycemia-recognized-Diabetes Mellitus', 'Diabetes Mellitus, Type 2-contribute-Glucose', 'ACE-assess-Heart Failure', 'ACE-treat-Heart Failure', 'Cardiovascular Diseases-begin-Glucose', 'Diabetes Mellitus-begin-Glucose', 'Obesity-contribute-Glucose', 'Digoxin-receive-Heart Failure', 'Digoxin-receive-Atrial Fibrillation', 'Digoxin-receive-Tachycardia', 'CRP-raised-Myocardial Infarction', 'CRP-raised-Death', 'Myocardial Infarction-measured-Death', 'CRP-measured-Myocardial Infarction', 'CRP-measured-Death', 'Cerebral Amyloid Angiopathy-investigated-Alzheimer Disease', 'Octreotide-control-Gastrointestinal Hemorrhage', 'Octreotide-control-Angiodysplasia', 'Atrophy-measure-Alzheimer Disease', 'KLK3-diagnosed-Prostatic Neoplasms', 'Atrophy-measure-Dementia, Vascular', 'KLK3-diagnosed-Neoplasms', 'Atrophy-measure-Dementia', 'Leukoencephalopathies-measure-Alzheimer Disease', 'Leukoencephalopathies-measure-Dementia, Vascular', 'Leukoencephalopathies-measure-Dementia', 'Cholesterol-associated-Stroke', 'Stroke-associated-Cholesterol', 'Neoplasms-recognized-GH1', 'Breast Neoplasms-treated-Heart Failure', 'Breast Neoplasms-treated-Doxorubicin', 'Dementia-result-Death', 'APOE-associated-Death', 'Death-associated-APOE', 'Kidney Diseases-develop-Drug-Related Side Effects and Adverse Reactions', 'Kidney Diseases-related-Aminoglycosides', 'Glucosamine-provide-Pain', 'Glucosamine-improve-Osteoarthritis', 'Idarubicin-employed-Leukemia, Myeloid, Acute', 'Heparin-used-Myocardial Infarction', 'Coronary Artery Disease-reduce-Gemfibrozil', 'Leukemia, Myeloid, Acute-receive-Idarubicin', 'Gemfibrozil-reduce-Myocardial Infarction', 'Disease Progression-receive-Idarubicin', 'Neoplasms-receive-Idarubicin', 'Diabetes Mellitus-compare-Glucose Intolerance', 'Diabetes Mellitus-compare-Glucose', 'Cholesterol-associated-Infections', 'Infections-associated-Cholesterol', 'AGT-associated-Hypertension', 'Hypertension-associated-AGT', 'Hypertension-aged-Heart Failure', 'Glucose Intolerance-revert-Glucose', 'Hypertension-selected-Hyperlipoproteinemia Type II', 'Hypertension-selected-Diabetes Mellitus', 'Glucose-excluded-Hyperlipoproteinemia Type II', 'Glucose-excluded-Diabetes Mellitus', 'Hypertension-selected-Cholesterol', 'Inflammation-elevated-Heart Failure', 'TNF-elevated-Heart Failure', 'Cholesterol-selected-Hyperlipoproteinemia Type II', 'Cholesterol-selected-Diabetes Mellitus', 'Cholesterol-associated-Myocardial Infarction', 'Myocardial Infarction-associated-Cholesterol', 'Cholesterol-associated-Angina, Unstable', 'Angina, Unstable-associated-Cholesterol', 'Glucose-predict-Stroke', 'Glucose-predict-Death', 'Glucose-predict-Cerebral Infarction', 'Heart Failure-defined-Digoxin', 'Glucose Intolerance-develop-Weight Gain', 'Chronic Disease-related-Neoplasms', 'Chronic Disease-related-Infections', 'Hyperinsulinism-associated-Glucose Intolerance', 'Glucose Intolerance-associated-Hyperinsulinism', 'Hyperinsulinism-develop-Glucose Intolerance', 'INS-associated-Glucose Intolerance', 'Glucose Intolerance-associated-INS', 'INS-develop-Glucose Intolerance', 'Coronary Artery Disease-reduce-Cholesterol', 'Death-reduce-Cholesterol', 'Lactose Intolerance-measure-Dyspnea', 'Lactose-measure-Dyspnea', 'LEP-correlate-CRP', 'MAPK8-correlated-GJA1', 'TP53-related-IGF1', 'ACE-increase-ACE2', 'INS-correlate-CRP', 'TP53-play-IGF1', 'GH1-enhance-GHRH', 'ING1-interact-MAP3K4', 'ING1-show-RAD50', 'HSPB1-increase-HSF1', 'BUB1B-reduce-NOS3', 'HSPB1-increase-HSPD1', 'DPP4-associated-BDNF', 'BDNF-associated-DPP4', 'SAA1-compare-CRP', 'ESR2-associated-SHBG', 'SHBG-associated-ESR2', 'CYP19A1-associated-SHBG', 'SHBG-associated-CYP19A1', 'LHB-associated-SHBG', 'SHBG-associated-LHB', 'ESR2-associated-INS', 'INS-associated-ESR2', 'CYP19A1-associated-INS', 'INS-associated-CYP19A1', 'KL-mediate-FGF23', 'LHB-associated-INS', 'INS-associated-LHB', 'SOX9-involved-COL2A1', 'TNFRSF11B-compare-CST3', 'GGH-compare-GHRH', 'SIRT1-bind-ZYX', 'TAT-affect-CD4', 'CD4-activated-TAT', 'TAT-favor-IL2', 'TAT-favor-CD4', 'IL1B-exert-IL6', 'TAT-favor-EOMES', 'MMP1-up-regulated-TIMP1', 'MMP1-up-regulated-LOXL4', 'GDF15-phosphorylate-SMAD2', 'EIF3E-shown-EIF3A', 'EIF3E-shown-COPS8', 'CST3-show-CRP', 'TRPV1-stimulate-TRPM8', 'NAA40-impact-INS', 'SYP-precede-CHAT', 'CRP-demonstrate-AKT1', 'BMPR1B-compare-GH1', 'LHCGR-compare-GH1', 'GHR-compare-GH1', 'TSHB-measure-BAX', 'TSHB-measure-CCAR2', 'TSHB-measure-TP53', 'TSHB-measure-TNF', 'LEP-associated-INS', 'INS-associated-LEP', 'SERPINA1-force-CFTR', 'ACADM-force-CFTR', 'ACADM-force-SERPINA1', 'LRRK2-decrease-PTGS2', 'LRRK2-decrease-TNFAIP3', 'IL6-decline-CRP', 'MCM8-sequenced-MCM9', 'LEP-known-TTR', 'GRM7-associated-DIRAS3', 'DIRAS3-associated-GRM7', 'SLPI-thought-LYZ', 'SLPI-compare-LYZ', 'GH1-increase-INS', 'CCN1-suppress-YAP1', 'NR1D1-reside-THRA', 'SIRT1-increase-KLF2', 'SIRT1-define-KLF2', 'IL6-associated-CRP', 'CRP-associated-IL6', 'KL-decrease-HSPA5', 'KL-decrease-DDIT3', 'PGK1-expressed-PGK2', 'KL-required-FGF23', 'LBP-associated-INS', 'INS-associated-LBP', 'TGFBR1-carried-MTOR', 'PTEN-carried-MTOR', 'MAP1LC3A-upregulate-CTSB', 'RARG-emphasized-RBP4', 'BACE1-initiate-ASS1', 'MMP3-increased-TIMP1', 'KL-associated-PTH', 'PTH-associated-KL', 'LEP-decrease-ADIPOQ', 'GGH-quantified-SST', 'MMP1-include-IL1A', 'MMP3-include-IL1A', 'MMP9-include-IL1A', 'MMP1-include-CXCL8', 'MMP3-include-CXCL8', 'MMP9-include-CXCL8', 'CRP-vary-APOE', 'AGT-associated-REN', 'REN-associated-AGT', 'NFASC-activate-NFE2L2', 'NFASC-activate-NQO1', 'CRP-seen-APOE', 'GH1-drive-GHRH', 'PPARG-affect-INS', 'ADAM17-regulate-TNF', 'Acarbose-decrease-Glucose', 'Heparin, Low-Molecular-Weight-receive-Heparin', 'GPER1-include-CYP19A1', 'Sucrose-receive-Acarbose', 'Eicosapentaenoic Acid-include-Fatty Acids', 'Glucosamine-increase-Glycosaminoglycans', 'Docosahexaenoic Acids-include-Fatty Acids', 'Eicosanoids-include-Oxylipins', 'Phosphatidylcholines-form-Lipid Bilayers', 'Oxylipins-produced-Fatty Acids, Unsaturated', 'Eicosanoids-produced-Fatty Acids, Unsaturated', 'Triglycerides-control-Cholesterol', 'Triglycerides-decrease-Cholesterol', 'Triglycerides-increase-Fish Oils', 'Fish Oils-improve-Triglycerides', 'Cholesterol-increase-Fish Oils', 'Fish Oils-increase-Eicosanoids', 'Atorvastatin-reduce-Triglycerides', 'Atorvastatin-reduce-Cholesterol', 'Fatty Acids-investigate-Trans Fatty Acids', 'Cholesterol-assessed-Cholestanol', 'Cholesterol-reflect-Cholestanol', 'Tetrodotoxin-consist-Muscimol', 'rs3755166-compare-rs2075252', 'rs3755166-compare-rs4668123', 'rs2075252-compare-rs4668123', 'Psychomotor Agitation-treat-Pain', 'Diabetes Mellitus-show-Death', 'Renal Insufficiency, Chronic-show-Death', 'Drug-Related Side Effects and Adverse Reactions-undergo-Neoplasms', 'Psychomotor Agitation-manage-Dementia', 'Drug-Related Side Effects and Adverse Reactions-receive-Neoplasms', 'Adenomatous Polyposis Coli-predict-Neoplasms', 'Neoplasms-associated-Dementia', 'Dementia-associated-Neoplasms', 'Fractures, Bone-caused-Wounds and Injuries', 'Death-related-Pneumonia', 'Infections-associated-Death', 'Death-associated-Infections', 'Death-include-Diabetes Mellitus', 'Death-occur-Silicosis', 'Hyperglycemia-associated-Death', 'Death-associated-Hyperglycemia', 'Hyperglycemia-associated-Pregnancy Complications, Infectious', 'Pregnancy Complications, Infectious-associated-Hyperglycemia', 'Hyperglycemia-associated-Stroke', 'Stroke-associated-Hyperglycemia', 'Mitochondrial Diseases-implicated-Glycogen Storage Disease Type II', 'Neoplasms-obtained-Diverticular Diseases', 'Lung Diseases-progress-Idiopathic Pulmonary Fibrosis', 'Neoplasms-obtained-Inflammatory Bowel Diseases', 'Hypotension, Orthostatic-associated-Death', 'Death-associated-Hypotension, Orthostatic', 'Bone Neoplasms-hear-Hearing Loss', 'Hypotension-related-Death', 'Cerebral Infarction-result-Death', 'Wounds and Injuries-enrolled-Spinal Cord Injuries', 'Ischemia-enrolled-Spinal Cord Injuries', 'Malnutrition-associated-Xerostomia', 'Xerostomia-associated-Malnutrition', 'Fragile X Syndrome-result-Death', 'Osteoporotic Fractures-result-Death', 'Stomach Neoplasms-diagnosed-Neoplasms', 'Alzheimer Disease-live-Dementia', 'Femoral Neck Fractures-combined-Respiratory Insufficiency', 'Femoral Neck Fractures-combined-Heart Failure', 'Femoral Neck Fractures-combined-Hypertension, Pulmonary', 'Inflammation-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-Inflammation', 'Femoral Neck Fractures-combined-Cerebral Infarction', 'Femoral Neck Fractures-combined-Atrial Fibrillation', 'Lymphedema-related-Breast Neoplasms', 'Graft Occlusion, Vascular-related-Hypertension', 'Graft Occlusion, Vascular-related-Inflammation', 'Brain Injuries, Traumatic-involve-Brain Injuries', 'Heredodegenerative Disorders, Nervous System-involve-Brain Injuries', 'Neoplasms-involve-Brain Injuries', 'Intellectual Disability-involve-Brain Injuries', 'Cardiovascular Diseases-exhibit-Inflammation', 'Death-exhibit-Inflammation', 'Diabetes Mellitus-confined-Inflammation', 'Diabetes Mellitus-exhibit-Inflammation', 'Neurogenic Inflammation-contribute-Alzheimer Disease', 'Lung Neoplasms-treat-Carcinoma, Non-Small-Cell Lung', 'Chronic Kidney Disease-Mineral and Bone Disorder-include-Anemia', 'Colorectal Neoplasms-rank-Neoplasms', 'Heart Failure-remain-Death', 'Tooth Loss-lead-Malnutrition', 'Carcinoma, Small Cell-diagnosed-Lung Neoplasms', 'Neoplasms-survey-Lung Neoplasms', 'Dementia-diagnosed-Death', 'Headache-approach-Dementia', 'Acute Pain-undertreat-Dementia', 'Death-approach-Dementia', 'Pain-undertreat-Dementia', 'Neoplasms-diagnosed-Urologic Neoplasms', 'Brain Neoplasms-serve-Death', 'Parkinson Disease-increase-Death', 'Aortic Valve Stenosis-diagnosed-Death', 'Angiodysplasia-diagnosed-Death', 'Hemophilia A-recognised-Blood Coagulation Disorders, Inherited', 'von Willebrand Diseases-recognised-Blood Coagulation Disorders, Inherited', 'Hyperalgesia-suffer-Death', 'Wasting Syndrome-coexist-Obesity', 'Wasting Syndrome-coexist-Frailty', 'Obesity-coexist-Frailty', 'Stroke-include-Chronic Disease', 'Hypertension-drive-Myotonic Dystrophy', 'Brain Injuries, Traumatic-considered-Alzheimer Disease', 'Vision Disorders-include-Dementia', 'Osteoporosis-address-Muscular Dystrophy, Duchenne', 'HIV Infections-experience-Inflammation', 'Albuminuria-associated-Vision Disorders', 'Vision Disorders-associated-Albuminuria', 'Dementia-associated-Vision Disorders', 'Vision Disorders-associated-Dementia', 'Dementia-include-Vision Disorders', 'Dementia-consider-Vision Disorders', 'Obesity-follow-Weight Loss', 'Atrial Fibrillation-associated-Death', 'Death-associated-Atrial Fibrillation', 'Weight Loss-improve-Diabetes Mellitus, Type 2', 'Arrhythmias, Cardiac-associated-Death', 'Death-associated-Arrhythmias, Cardiac', 'Weight Loss-improve-Obesity', 'Neoplasms-collected-Death', 'HIV Infections-lead-Death', 'Osteoporosis-become-Fractures, Bone', 'Osteoporosis-become-Death', 'Fractures, Bone-become-Death', 'Myocardial Infarction-associated-Death', 'Death-associated-Myocardial Infarction', 'Erectile Dysfunction-associated-Death', 'Death-associated-Erectile Dysfunction', 'Inflammation-associated-Dementia', 'Dementia-associated-Inflammation', 'Headache Disorders, Secondary-predict-Death', 'Erectile Dysfunction-predict-Death', 'Neurodegenerative Diseases-associated-Infections', 'Infections-associated-Neurodegenerative Diseases', 'Neurodegenerative Diseases-triggered-Infections', 'Lupus Erythematosus, Systemic-adhere-Hypertension', 'Osteoporosis-based-Fractures, Bone', 'Osteoporosis-used-Fractures, Bone', 'Osteoporosis-prevent-Fractures, Bone', 'Alzheimer Disease-considered-Dementia', 'Fractures, Bone-present-Wounds and Injuries', 'Fractures, Open-present-Wounds and Injuries', 'Hip Fractures-associated-Delirium', 'Delirium-associated-Hip Fractures', 'Liver Diseases-leverage-HIV Infections', 'Malaria-increase-Diabetes Mellitus', 'Malaria-increase-Cardiovascular Diseases', 'Hyperglycemia-associated-Delirium', 'Delirium-associated-Hyperglycemia', 'Non-alcoholic Fatty Liver Disease-renamed-Fatty Liver', 'Colorectal Neoplasms-reduce-Death', 'Adenomatous Polyps-reduce-Death', 'Precancerous Conditions-reduce-Death', 'Hip Dislocation-combined-Granuloma, Plasma Cell', 'Coronary Artery Disease-categorized-Mesenteric Vascular Occlusion', 'Coronary Artery Disease-lead-Hypoxia', 'Coronary Artery Disease-lead-Necrosis', 'Mesenteric Vascular Occlusion-lead-Coronary Artery Disease', 'Mesenteric Vascular Occlusion-lead-Hypoxia', 'Cardiovascular Diseases-include-Death', 'Mesenteric Vascular Occlusion-lead-Necrosis', 'Infections-compare-Heart Diseases', 'Infections-associated-Colonic Neoplasms', 'Colonic Neoplasms-associated-Infections', 'Pneumonia-treat-Femoral Fractures', 'Pneumonia-identify-Infections', 'Femoral Fractures-identify-Infections', 'Pneumonia-treat-Fractures, Bone', 'Death-associated-Sarcoidosis', 'Sarcoidosis-associated-Death', 'Cheilitis-present-Fibroma', 'Venous Thrombosis-associated-Tachycardia, Ventricular', 'Tachycardia, Ventricular-associated-Venous Thrombosis', 'Arthritis, Rheumatoid-include-Hyperplasia', 'Hypothyroidism-examine-Cardiac Output, Low', 'Hypothyroidism-fall-Cardiac Output, Low', 'Cardiovascular Diseases-confer-Death', 'Diabetes Mellitus, Type 2-confer-Death', 'Liver Cirrhosis-identify-HIV Infections', 'Death-increase-HIV Infections', 'Aortic Aneurysm, Abdominal-lead-Rupture', 'Rupture-lead-Aortic Diseases', 'Alzheimer Disease-superimposed-Leukoencephalopathies', 'Colorectal Neoplasms-undergo-Muscular Dystrophy, Duchenne', 'Headache-suffer-Vertigo', 'Neoplasms-suffer-Azoospermia', 'Kidney Diseases-associated-Death', 'Death-associated-Kidney Diseases', 'Neoplasms-know-Erectile Dysfunction', 'Breast Neoplasms, Male-know-Erectile Dysfunction', 'Heart Diseases-diagnosed-Aortic Valve Stenosis', 'Dementia-include-Lewy Body Disease', 'Venous Thrombosis-delay-Fractures, Bone', 'Diabetes Mellitus-incorporate-Hemophilia A', 'Hypertension-associate-Cardiovascular Diseases', 'Cardiovascular Diseases-associate-Hypertension', 'Hypertension-associate-Dementia', 'Dementia-associate-Hypertension', 'Dementia-assess-Delirium', 'Tetany-included-Death', 'Osteoporosis-reduce-Death', 'Fractures, Bone-reduce-Death', 'Death-found-Polycystic Ovary Syndrome', 'Hypotension, Orthostatic-include-Hypertension', 'Sarcopenia-reversed-Infections', 'Malnutrition-reversed-Infections', 'Myocardial Infarction-associated-Acute Coronary Syndrome', 'Acute Coronary Syndrome-associated-Myocardial Infarction', 'Neurodegenerative Diseases-implicated-Alzheimer Disease', 'Glycogen Storage Disease Type II-remain-Vision Disorders', 'Fibrosis-explain-Xerostomia', 'Vasculitis-manifested-Glomerulonephritis', 'Acute Kidney Injury-manifested-Glomerulonephritis', 'Brain Ischemia-investigate-Ischemia', 'Headache-associated-Cerebral Small Vessel Diseases', 'Cerebral Small Vessel Diseases-associated-Headache', 'Headache Disorders, Secondary-associated-Cerebral Small Vessel Diseases', 'Cerebral Small Vessel Diseases-associated-Headache Disorders, Secondary', 'Pneumonia-account-Infections', 'Pneumonia-account-Death', 'Death-related-Infections', 'Infections-include-Chronic Disease', 'Infections-present-Nervous System Diseases', 'Sarcopenia-involve-Inflammation', 'Osteoporosis-decrease-Disorders of Sex Development', 'Dementia-ascertained-Death', 'Muscular Diseases-elevate-Diabetes Mellitus, Type 2', 'Obesity-protect-Death', 'Hydrocephalus-present-Leukoencephalopathies', 'Atherosclerosis-study-Cardiovascular Diseases', 'Death-use-Cryoglobulinemia', 'Parkinson Disease-diagnosed-Neurodegenerative Diseases', 'Brain Injuries, Traumatic-contribute-Chronic Disease', 'Brain Injuries, Traumatic-contribute-Death', 'Brain Injuries, Traumatic-associated-Death', 'Death-associated-Brain Injuries, Traumatic', 'Sarcopenia-associated-Hypertension', 'Hypertension-associated-Sarcopenia', 'Sarcopenia-correlate-Death', 'Wounds and Injuries-encouraged-Pulmonary Embolism', 'Wounds and Injuries-prevent-Pulmonary Embolism', 'Mastocytosis, Systemic-contribute-Alzheimer Disease', 'Wounds and Injuries-encouraged-Venous Thrombosis', 'Dementia-undertake-Infections', 'Arthritis, Rheumatoid-linked-Cardiovascular Diseases', 'Hypertension-related-Death', 'Muscle Weakness-prevent-Weight Loss', 'Muscle Weakness-prevent-Obesity', 'Diabetes Mellitus-change-Death', 'Hypertension-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-Hypertension', 'Death-hospitalized-Pneumonia', 'Death-related-Prediabetic State', 'Death-related-Diabetes Mellitus', 'Tauopathies-compare-Craniocerebral Trauma', 'Anemia-associated-Death', 'Death-associated-Anemia', 'Cerebrovascular Disorders-increase-Alzheimer Disease', 'Cerebral Infarction-reduced-Infarction, Middle Cerebral Artery', 'Myocardial Infarction-reported-Death', 'Muscular Dystrophy, Duchenne-diagnose-Osteoporosis', 'Heredodegenerative Disorders, Nervous System-represent-Sensation Disorders', 'Musculoskeletal Diseases-represent-Sensation Disorders', 'Nerve Degeneration-observed-Alzheimer Disease', 'Atrophy-associated-Alzheimer Disease', 'Alzheimer Disease-associated-Atrophy', 'Vision Disorders-fall-Cardiac Output, Low', 'Neoplasms-identify-Stomach Neoplasms', 'Osteoporosis-cause-Death', 'Atrial Fibrillation-associated-Dementia', 'Dementia-associated-Atrial Fibrillation', 'Asthma-associated-Atherosclerosis', 'Atherosclerosis-associated-Asthma', 'Asthma-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-Asthma', 'Long QT Syndrome-prevent-Arrhythmias, Cardiac', 'Breast Neoplasms-obtained-Neoplasms', 'Neoplasms-obtained-Breast Neoplasms', 'Renal Insufficiency, Chronic-associated-Arrhythmias, Cardiac', 'Arrhythmias, Cardiac-associated-Renal Insufficiency, Chronic', 'Chronic Kidney Disease-Mineral and Bone Disorder-associated-Arrhythmias, Cardiac', 'Arrhythmias, Cardiac-associated-Chronic Kidney Disease-Mineral and Bone Disorder', 'Joint Diseases-lead-Pain', 'Osteoarthritis-characterized-Pain', 'Osteoarthritis-characterized-Edema', 'Sarcopenia-increase-Fractures, Bone', 'Neurodegenerative Diseases-characterized-Pain', 'Neurodegenerative Diseases-characterized-Edema', 'Sarcopenia-affect-Death', 'HIV Infections-associated-Atrophy', 'Atrophy-associated-HIV Infections', 'HIV Infections-localise-Atrophy', 'Sleep Initiation and Maintenance Disorders-assess-Sleep Wake Disorders', 'Alzheimer Disease-assess-Sleep Wake Disorders', 'Osteoporosis-increase-Fractures, Bone', 'Cardiovascular Diseases-linked-Atrophy', 'Osteoporosis-affect-Death', 'Fractures, Bone-affect-Death', 'Alzheimer Disease-include-Neurodegenerative Diseases', 'Sarcopenia-screen-Stomach Neoplasms', 'Sarcopenia-include-Stomach Neoplasms', 'Parkinson Disease-enrol-Parkinson Disease, Secondary', 'Polycystic Ovary Syndrome-characterized-Metabolic Diseases', 'Factor XII Deficiency-protected-Hypertension', 'Factor XII Deficiency-protected-Kidney Diseases', 'Hypertension-protected-Kidney Diseases', 'HIV Infections-reduce-Death', 'Hip Dislocation, Congenital-use-Stroke', 'HIV Infections-predispose-Pneumococcal Infections', 'Death-predispose-Pneumococcal Infections', 'Adenomatous Polyposis Coli-derived-Myoclonic Epilepsies, Progressive', 'Joint Dislocations-associated-Myotonic Dystrophy', 'Myotonic Dystrophy-associated-Joint Dislocations', 'Sarcopenia-associated-Lipid Metabolism Disorders', 'Lipid Metabolism Disorders-associated-Sarcopenia', 'Sarcopenia-based-Ataxia', 'Gout-develop-Parkinson Disease', 'Liver Neoplasms-report-Pain', 'Atrial Fibrillation-develop-Stroke', 'Neurodegenerative Diseases-associated-Death', 'Death-associated-Neurodegenerative Diseases', 'Lymphatic Diseases-appear-Neoplasms', 'Cerebral Infarction-combined-Hip Fractures', 'Severe Acute Respiratory Syndrome-infect-Infections', 'Cerebral Infarction-lead-Death', 'Hip Fractures-lead-Death', 'Bradycardia-associated-Ventricular Dysfunction, Left', 'Ventricular Dysfunction, Left-associated-Bradycardia', 'Cerebrovascular Disorders-include-Polycystic Kidney Diseases', 'Bradycardia-associated-Heart Failure', 'Heart Failure-associated-Bradycardia', 'Eye Abnormalities-prevent-Vision Disorders', 'Pulmonary Disease, Chronic Obstructive-contribute-Death', 'Dementia-develop-Urinary Incontinence', 'Metabolic Syndrome-drawe-Osteoarthritis', 'Obesity-drawe-Osteoarthritis', 'Turner Syndrome-prevent-Osteoporosis', 'Turner Syndrome-reduce-Fractures, Bone', 'Osteoporosis-undergo-Fractures, Compression', 'Osteoporosis-reduce-Fractures, Bone', 'Neoplasms-associated-Melanoma', 'Melanoma-associated-Neoplasms', 'Neoplasms-associated-Autoimmune Diseases', 'Autoimmune Diseases-associated-Neoplasms', 'Melanoma-associated-Autoimmune Diseases', 'Autoimmune Diseases-associated-Melanoma', 'Melanoma-occur-Autoimmune Diseases', 'Autoimmune Diseases-occur-Neoplasms', 'Diabetes Mellitus-cause-Vision Disorders', 'Vasculitis-cause-Vision Disorders', 'Mesenteric Vascular Occlusion-cause-Vision Disorders', 'Neoplasms-estimate-Death', 'Obesity-capture-Communicable Diseases', 'Osteoporosis-experience-Low Back Pain', 'Osteoporosis-experience-Fractures, Bone', 'Low Back Pain-experience-Fractures, Bone', 'Hematoma, Subdural, Acute-found-Brain Injuries, Traumatic', 'Inflammation-linked-Stroke', 'Sarcopenia-associated-Death', 'Death-associated-Sarcopenia', 'Cushing Syndrome-cause-Sarcopenia', 'Calcinosis-associated-Cardiomyopathy, Hypertrophic', 'Cardiomyopathy, Hypertrophic-associated-Calcinosis', 'Diabetes Mellitus-associated-Obesity', 'Obesity-associated-Diabetes Mellitus', 'Dementia-associated-Obesity', 'Obesity-associated-Dementia', 'Chronic Pain-mediate-Sleep Wake Disorders', 'Drug-Related Side Effects and Adverse Reactions-proved-Hip Fractures', 'Femoral Neck Fractures-treat-Renal Insufficiency, Chronic', 'Delirium-reduce-Hip Fractures', 'Diabetes Mellitus-associated-Muscular Diseases', 'Muscular Diseases-associated-Diabetes Mellitus', 'Death-observed-Sarcopenia', 'Death-occur-Cardiovascular Diseases', 'Brain Injuries, Traumatic-present-Wounds and Injuries', 'Gastritis-diagnose-Infections', 'Weight Loss-associated-Heart Failure', 'Heart Failure-associated-Weight Loss', 'Cachexia-associated-Heart Failure', 'Heart Failure-associated-Cachexia', 'Blindness-caused-Glaucoma', 'Epilepsy-come-Seizures', 'Hematoma, Subdural, Acute-followed-Diabetes Mellitus', 'Stroke-assessed-Delirium', 'Atrophy-predict-Delirium', 'Death-calculated-Myocardial Infarction', 'Death-calculated-Coronary Artery Disease', 'Mitochondrial Diseases-contribute-Alzheimer Disease', 'Infections-estimated-Coronavirus Infections', 'Death-reduce-Stomach Neoplasms', 'Pneumonia-reduce-Stomach Neoplasms', 'Pulmonary Disease, Chronic Obstructive-derived-Death', 'Parkinson Disease, Secondary-predate-Sleep Initiation and Maintenance Disorders', 'Parkinson Disease, Secondary-predate-Disorders of Excessive Somnolence', 'Parkinson Disease, Secondary-predate-Apnea', 'Parkinson Disease, Secondary-predate-Restless Legs Syndrome', 'Constriction, Pathologic-identify-Uterine Cervicitis', 'Fractures, Bone-associated-Death', 'Death-associated-Fractures, Bone', 'Delirium-undergo-Hip Fractures', 'Death-associated-Cholecystitis', 'Cholecystitis-associated-Death', 'Cholecystitis, Acute-undergo-Fractures, Open', 'Bone Neoplasms-treat-Osteoporosis', 'Bone Neoplasms-treat-Bone Diseases, Metabolic', 'Fractures, Open-represent-Gallstones', 'Fractures, Open-represent-Death', 'Mitochondrial Diseases-linked-Delirium', 'Gallstones-represent-Death', 'Adrenal Insufficiency-determine-Sarcopenia', 'Pain-manage-Sarcopenia', 'Weight Loss-fall-Chronic Disease', 'Weight Loss-fall-Fatigue', 'Neoplasms-contribute-Heart Arrest', 'Wounds and Injuries-reduce-Vascular System Injuries', 'Cerebrovascular Disorders-associated-Parkinson Disease, Secondary', 'Parkinson Disease, Secondary-associated-Cerebrovascular Disorders', 'Pancreatic Neoplasms-become-Neoplasms', 'Pancreatic Neoplasms-become-Death', 'Neoplasms-become-Death', 'Neoplasms-related-Death', 'Weight Loss-reduce-Hypertension', 'Parkinson Disease, Secondary-use-Parkinson Disease', 'Hypoalbuminemia-increase-Infections', 'Death-obtained-Communicable Diseases', 'Hypoalbuminemia-predict-Hypoproteinemia', 'Pancreatic Neoplasms-obtained-Communicable Diseases', 'Infections-predict-Hypoproteinemia', 'Lipoma-increase-Metabolic Syndrome', 'Scoliosis-combined-Spinal Stenosis', 'Diabetes Mellitus, Type 2-produce-Diabetes Mellitus', 'Sarcopenia-defined-Muscular Atrophy', 'Dysentery-decline-Death', 'Progeria-characterized-Death', 'Progeria-characterized-Myocardial Infarction', 'Progeria-characterized-Stroke', 'Progeria-characterized-Heart Failure', 'Death-characterized-Myocardial Infarction', 'Fractures, Bone-associate-Death', 'Death-associate-Fractures, Bone', 'Death-characterized-Stroke', 'Death-characterized-Heart Failure', 'Progeria-include-Lipodystrophy', 'Progeria-thrive-Lipodystrophy', 'Progeria-include-Fibrosis', 'Progeria-thrive-Fibrosis', 'Death-include-Progeria', 'Lipodystrophy-thrive-Fibrosis', 'Lipodystrophy-thrive-Death', 'Fibrosis-thrive-Death', 'Neoplasms-differentiated-Kidney Failure, Chronic', 'Neoplasms-differentiated-Nervous System Diseases', 'Arteritis-involve-Radiculopathy', 'Bacteremia-experience-Sepsis', 'Arthritis, Rheumatoid-identify-Cardiac Output, Low', 'Ventricular Fibrillation-associated-Parkinson Disease', 'Parkinson Disease-associated-Ventricular Fibrillation', 'Hearing Loss-co-occur-Dementia', 'Neoplasms-diagnosed-Dementia', 'Hematoma-assess-Death', 'Hearing Loss-aid-Dementia', 'Blood Coagulation Disorders-induced-Sepsis', 'Hip Fractures-associate-Death', 'Death-associate-Hip Fractures', 'Low Back Pain-base-Hip Dislocation, Congenital', 'Low Back Pain-identify-Hip Dislocation, Congenital', 'Infections-associated-Hypothermia', 'Hypothermia-associated-Infections', 'Oculocerebrorenal Syndrome-increase-Diabetes Mellitus', 'Myocardial Infarction-include-Cardiovascular Diseases', 'Stroke-include-Cardiovascular Diseases', 'Death-include-Coma', 'Coma-include-Hematoma, Subdural', 'Renal Insufficiency, Chronic-associated-Fractures, Bone', 'Fractures, Bone-associated-Renal Insufficiency, Chronic', 'Hemorrhage-associated-Death', 'Death-associated-Hemorrhage', 'Soft Tissue Infections-associated-Death', 'Death-associated-Soft Tissue Infections', 'Cerebrovascular Disorders-associated-Atrophy', 'Atrophy-associated-Cerebrovascular Disorders', 'Cerebrovascular Disorders-associated-Alzheimer Disease', 'Alzheimer Disease-associated-Cerebrovascular Disorders', 'Cerebrovascular Disorders-associated-Neurodegenerative Diseases', 'Neurodegenerative Diseases-associated-Cerebrovascular Disorders', 'Sleep Initiation and Maintenance Disorders-associated-Hypertension', 'Hypertension-associated-Sleep Initiation and Maintenance Disorders', 'Sleep Initiation and Maintenance Disorders-associated-Myocardial Infarction', 'Myocardial Infarction-associated-Sleep Initiation and Maintenance Disorders', 'Sleep Initiation and Maintenance Disorders-associated-Stroke', 'Stroke-associated-Sleep Initiation and Maintenance Disorders', 'Sleep Initiation and Maintenance Disorders-associated-Metabolic Syndrome', 'Metabolic Syndrome-associated-Sleep Initiation and Maintenance Disorders', 'Sleep Initiation and Maintenance Disorders-associated-Prostatic Neoplasms', 'Prostatic Neoplasms-associated-Sleep Initiation and Maintenance Disorders', 'Coronary Artery Disease-complicated-Renal Insufficiency', 'Coronary Artery Disease-exhibit-Cerebrovascular Disorders', 'Coronary Artery Disease-exhibit-Dementia', 'Hypoxia-result-Peripheral Arterial Disease', 'Spinal Cord Injuries-respond-Wounds and Injuries', 'Inflammation-increase-Cardiovascular Diseases', 'Arbovirus Infections-present-Death', 'Sarcopenia-associated-Renal Insufficiency, Chronic', 'Renal Insufficiency, Chronic-associated-Sarcopenia', 'Fractures, Bone-combine-Osteoporosis', 'Pelvic Neoplasms-combine-Fractures, Open', 'Osteoporosis-combine-Fractures, Open', 'Hypokinesia-affect-Parkinson Disease', 'Hypokinesia-include-Parkinson Disease', 'Tremor-include-Parkinson Disease', 'Thromboembolism-related-Aortic Arch Syndromes', 'Muscle Rigidity-include-Parkinson Disease', 'Bursitis-cause-Pain', 'Thrombophlebitis-cause-Thrombosis', 'Thrombophlebitis-caused-Cerebral Infarction', 'Thrombosis-cause-Cerebral Infarction', 'Pneumonia-affect-Death', 'Sarcopenia-elevate-Metabolic Diseases', 'Cerebral Small Vessel Diseases-associated-Dementia', 'Dementia-associated-Cerebral Small Vessel Diseases', 'Seizures-associated-Stroke', 'Stroke-associated-Seizures', 'Chronic Pain-associated-Dementia', 'Dementia-associated-Chronic Pain', 'Atrophy-associated-Abnormalities, Drug-Induced', 'Abnormalities, Drug-Induced-associated-Atrophy', 'Chronic Disease-understand-Lung Neoplasms', 'Chronic Disease-understand-Death', 'Dementia-predict-Diabetes Mellitus', 'Pneumonia-predict-Death', 'Obesity-show-Inflammation', 'Sarcopenia-occur-Chronic Disease', 'Sarcopenia-link-Obesity', 'HIV Infections-live-Fractures, Bone', 'Sarcopenia-link-Non-alcoholic Fatty Liver Disease', 'Chronic Disease-link-Obesity', 'Prostatic Neoplasms-reduce-Death', 'Arthritis, Rheumatoid-identify-Death', 'Arthritis, Rheumatoid-experience-Death', 'Sarcopenia-associated-Coronary Artery Disease', 'Coronary Artery Disease-associated-Sarcopenia', 'Brain Injuries, Traumatic-prioritised-Wounds and Injuries', 'Stomach Neoplasms-become-Neoplasms', 'Gitelman Syndrome-associated-Chondrocalcinosis', 'Chondrocalcinosis-associated-Gitelman Syndrome', 'Sarcopenia-attributed-Diabetes Mellitus', 'Sarcopenia-attributed-Obesity', 'Sarcopenia-attributed-Coronary Artery Disease', 'Vasculitis-characterised-Inflammation', 'Chondrocalcinosis-include-Gitelman Syndrome', 'Autoimmune Diseases-characterised-Inflammation', 'Magnesium Deficiency-associated-Critical Illness', 'Critical Illness-associated-Magnesium Deficiency', 'Malnutrition-influence-Chronic Disease', 'Stroke-treat-Inflammation', 'Hemophilia B-treated-Hemophilia A', 'Muscle Weakness-fall-Cardiac Output, Low', 'Pelvic Organ Prolapse-tolerated-Obesity', 'Osteoporosis-present-Fractures, Bone', 'Narcolepsy-result-Mastocytosis, Systemic', 'Weight Gain-observed-Narcolepsy', 'Obesity, Abdominal-observed-Narcolepsy', 'Narcolepsy-associated-Immunologic Deficiency Syndromes', 'Immunologic Deficiency Syndromes-associated-Narcolepsy', 'Immunologic Deficiency Syndromes-associated-Obesity, Abdominal', 'Obesity, Abdominal-associated-Immunologic Deficiency Syndromes', 'Narcolepsy-show-Obesity, Abdominal', 'Pelvic Pain-live-HIV Infections', 'Hemorrhage-associated-Fistula', 'Fistula-associated-Hemorrhage', 'Substance-Related Disorders-promote-Death', 'Fractures, Bone-occur-Wounds and Injuries', 'Fractures, Bone-occur-Wounds, Nonpenetrating', 'Hearing Loss-co-exist-Dementia', 'Neurodegenerative Diseases-cause-Vision Disorders', 'Immunologic Deficiency Syndromes-consider-Infections', 'Sleep Initiation and Maintenance Disorders-keep-Pain', 'Stroke-associated-Hemorrhage', 'Hemorrhage-associated-Stroke', 'Renal Insufficiency, Chronic-live-HIV Infections', 'Severe Acute Respiratory Syndrome-caused-Cushing Syndrome', 'Kidney Diseases-associated-Leukoencephalopathies', 'Leukoencephalopathies-associated-Kidney Diseases', 'Kidney Diseases-associated-Renal Insufficiency, Chronic', 'Renal Insufficiency, Chronic-associated-Kidney Diseases', 'Retinal Arterial Macroaneurysm-seen-Hypertension', 'Hemorrhage-occur-Cushing Syndrome', 'Purpura Fulminans-occur-Cushing Syndrome', 'Peripheral Nervous System Diseases-become-Chronic Disease', 'Inflammation-increase-Chronic Disease', 'Cushing Syndrome-cause-Inflammation', 'Cushing Syndrome-increase-Purpura Fulminans', 'Inflammation-increase-Purpura Fulminans', 'Hypertension-seem-Nausea', 'Cardiovascular Diseases-associated-Stroke', 'Stroke-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-Myocardial Infarction', 'Myocardial Infarction-associated-Cardiovascular Diseases', 'Obesity, Abdominal-present-Hypertension', 'Fractures, Bone-carry-Death', 'Delirium-precipitate-Dementia', 'Keratitis, Dendritic-include-Inflammation', 'Keratitis, Dendritic-include-Pain', 'Cerebral Infarction-admitted-Stroke', 'Ischemia-admitted-Stroke', 'Death-lead-Infections', 'Death-lead-Neoplasms', 'Glucose Intolerance-diagnosed-Diabetes Mellitus', 'Deglutition Disorders-associated-Dehydration', 'Dehydration-associated-Deglutition Disorders', 'Diabetes Mellitus-influence-Thrombosis', 'Tuberculosis, Pulmonary-create-Death', 'Infections-create-Death', 'Atherosclerosis-influence-Thrombosis', 'Sarcopenia-related-Obesity', 'Sarcopenia-related-Diabetes Mellitus', 'Renal Insufficiency, Chronic-face-Death', 'Pre-Eclampsia-characterized-Proteinuria', 'Hypertension-characterized-Proteinuria', 'Peripheral Nervous System Diseases-include-Neoplasms', 'Sarcopenia-aid-Death', 'Progeria-associated-Aneurysm', 'Aneurysm-associated-Progeria', 'Progeria-associated-Death', 'Death-associated-Progeria', 'Progeria-associated-Stroke', 'Stroke-associated-Progeria', 'Catatonia-present-Chronic Disease', 'Inflammation-measured-Diabetes Mellitus', 'Heart Failure-involved-Inflammation', 'Diabetes Mellitus-involved-Inflammation', 'Infections-use-Myositis', 'Death-consist-Dementia', 'Ossification of Posterior Longitudinal Ligament-detect-Alzheimer Disease', 'Hip Fractures-diagnosed-Cross Infection', 'Sleep Wake Disorders-associated-Tinnitus', 'Tinnitus-associated-Sleep Wake Disorders', 'Dementia-experience-Headache Disorders, Secondary', 'Headache Disorders, Secondary-associated-Brain Diseases', 'Brain Diseases-associated-Headache Disorders, Secondary', 'Pelvic Neoplasms-associated-Osteoporosis', 'Osteoporosis-associated-Pelvic Neoplasms', 'Seizures-used-Epilepsy', 'Obesity, Abdominal-include-Obesity', 'Metabolic Syndrome-observed-Acute Coronary Syndrome', 'Fever-involve-Diabetes Mellitus', 'Fever-involve-Asthma', 'Hypotension-result-Osteoarthritis', 'Fever-associated-Infections', 'Infections-associated-Fever', 'Diabetes Mellitus-associated-Infections', 'Infections-associated-Diabetes Mellitus', 'Asthma-associated-Infections', 'Infections-associated-Asthma', 'Atrial Fibrillation-suffer-Gastrointestinal Hemorrhage', 'Atrial Fibrillation-associated-Gastrointestinal Hemorrhage', 'Gastrointestinal Hemorrhage-associated-Atrial Fibrillation', 'Hypertension-associated-Alzheimer Disease', 'Alzheimer Disease-associated-Hypertension', 'Hypertension-associated-Dementia', 'Dementia-associated-Hypertension', 'Psychomotor Agitation-occur-Dementia', 'Cardiomyopathies-studied-Death', 'Heart Failure-studied-Death', 'Pneumonia, Aspiration-account-Pneumonia', 'Death-included-Alzheimer Disease', 'Breast Neoplasms-result-Fatigue', 'Neoplasms-used-Death', 'Inflammation-play-Alzheimer Disease', 'Death-associated-Pulmonary Disease, Chronic Obstructive', 'Pulmonary Disease, Chronic Obstructive-associated-Death', 'Gastrointestinal Hemorrhage-include-Gastrointestinal Stromal Tumors', 'Osteoporosis-characterized-Fatigue', 'Osteoporosis-improve-Fatigue', 'Fatigue-improve-Fractures, Bone', 'Osteoporotic Fractures-subjected-Fatigue', 'Deglutition Disorders-result-Shock', 'Deglutition Disorders-result-Wounds and Injuries', 'Neoplasms-include-Orbital Neoplasms', 'Deglutition Disorders-result-Head and Neck Neoplasms', 'Deglutition Disorders-result-Cerebrovascular Disorders', 'Deglutition Disorders-result-Neurodegenerative Diseases', 'Sleep Initiation and Maintenance Disorders-associated-Memory Disorders', 'Memory Disorders-associated-Sleep Initiation and Maintenance Disorders', 'Neoplasms-infected-Infections', 'Infections-avoid-Death', 'Atrial Fibrillation-proposed-Stroke', 'Migraine Disorders-associated-Irritable Bowel Syndrome', 'Irritable Bowel Syndrome-associated-Migraine Disorders', 'Migraine Disorders-associated-Peptic Ulcer', 'Peptic Ulcer-associated-Migraine Disorders', 'Migraine Disorders-associated-Ulcer', 'Ulcer-associated-Migraine Disorders', 'Dementia-result-Essential Tremor', 'Sepsis-associated-Wounds and Injuries', 'Wounds and Injuries-associated-Sepsis', 'Death-associated-Wounds and Injuries', 'Wounds and Injuries-associated-Death', 'Sarcopenia-lead-Respiratory Insufficiency', 'Death-increased-Tremor', 'Shock, Cardiogenic-remain-Death', 'Myocardial Infarction-remain-Death', 'Respiratory Distress Syndrome-known-Obesity', 'Respiratory Distress Syndrome-known-Diabetes Mellitus', 'Respiratory Distress Syndrome-cause-Hypertension', 'Neoplasms-challenge-Death', 'Ischemia-include-Stroke', 'Sarcopenia-defined-Obesity', 'Pelvic Neoplasms-associated-Death', 'Death-associated-Pelvic Neoplasms', 'Ischemia-include-Cerebral Infarction', 'Liver Diseases-include-Death', 'Alzheimer Disease-contribute-Metabolic Diseases', 'Heart Failure-include-Death', 'Anemia-include-Death', 'Kyphosis-related-Paraplegia', 'Pneumonia-cause-Death', 'Stroke-include-Atrial Fibrillation', 'Ischemia-include-Atrial Fibrillation', 'Hemorrhage-include-Atrial Fibrillation', 'Death-include-Atrial Fibrillation', 'Delirium-develop-Stroke', 'Diabetes Mellitus-associated-Neurodegenerative Diseases', 'Neurodegenerative Diseases-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-Cerebral Small Vessel Diseases', 'Cerebral Small Vessel Diseases-associated-Diabetes Mellitus', 'Mitral Valve Insufficiency-diagnosed-Heart Failure', 'Chronic Disease-use-Xerostomia', 'Chronic Disease-evaluate-Xerostomia', 'Neoplasms-used-Drug-Related Side Effects and Adverse Reactions', 'Mitral Valve Insufficiency-associate-Death', 'Death-associate-Mitral Valve Insufficiency', 'Hip Fractures-undergo-Femoral Neck Fractures', 'Death-live-HIV Infections', 'Lymphoma, Non-Hodgkin-experience-Neoplasms', 'Hypotension-serve-Fractures, Bone', 'Hypotension-serve-Intra-Articular Fractures', 'Parkinson Disease-report-Fatigue', 'Scoliosis-alleviate-Pain', 'Scoliosis-improve-Musculoskeletal Diseases', 'Pain-improve-Musculoskeletal Diseases', 'Cardiovascular Diseases-based-Atherosclerosis', 'Infections-associated-Dementia', 'Dementia-associated-Infections', 'Infections-associated-Dementia, Vascular', 'Dementia, Vascular-associated-Infections', 'Infections-associated-Alzheimer Disease', 'Alzheimer Disease-associated-Infections', 'Alzheimer Disease-documented-Death', 'Infections-increase-Dementia', 'Death-fall-Cardiac Output, Low', 'Fasciculation-associated-Death', 'Death-associated-Fasciculation', 'Gangliosidosis, GM1-suggest-Atherosclerosis', 'Cardiomegaly-lead-Heart Failure', 'Respiratory Tract Diseases-associated-Death', 'Death-associated-Respiratory Tract Diseases', 'Stroke-distinguish-Atrial Fibrillation', 'Stroke-underlie-Atrial Fibrillation', 'Atrial Fibrillation-distinguish-Stroke', 'Obesity-increase-Cardiovascular Diseases', 'Atrial Fibrillation-associated-Stroke', 'Stroke-associated-Atrial Fibrillation', 'Cerebral Hemorrhage-demonstrate-Coma', 'Cardiovascular Diseases-associated-Obesity', 'Obesity-associated-Cardiovascular Diseases', 'Death-develop-Dementia', 'Ulcer-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-Ulcer', 'Carcinoma, Squamous Cell-included-Tachycardia, Atrioventricular Nodal Reentry', 'Skin Neoplasms-include-Melanoma', 'Death-improve-Infections', 'Melanoma-remain-Death', 'Inflammatory Bowel Diseases-demonstrate-Necrosis', 'Vision Disorders-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-Vision Disorders', 'Alcoholism-increase-Stroke', 'Heredodegenerative Disorders, Nervous System-associated-Inflammation', 'Inflammation-associated-Heredodegenerative Disorders, Nervous System', 'Neoplasms-compare-Death', 'Pneumonia-become-Respiration Disorders', 'Pneumonia-become-Severe Acute Respiratory Syndrome', 'Tuberculosis-address-Tuberculosis, Meningeal', 'Death-defined-Cardiovascular Diseases', 'Pneumothorax-described-Infections', 'Pulmonary Atelectasis-caused-Osteonecrosis', 'Death-elicit-Shock', 'Death-elicit-Neoplasms', 'Breast Neoplasms-quantify-Neoplasm Metastasis', 'Hip Fractures-experience-Pain', 'Albuminuria-exhibit-Kidney Diseases', 'Glomerulonephritis-exhibit-Kidney Diseases', 'Neoplasms-include-Angina Pectoris', 'Neoplasms-include-Diabetes Mellitus', 'Neoplasms-include-Heart Diseases', 'Fractures, Bone-tend-Death', 'Fractures, Bone-suffer-Death', 'Stroke-display-Neurologic Manifestations', 'Pulmonary Disease, Chronic Obstructive-become-Death', 'Sarcopenia-increase-Death', 'Myalgia-increase-Fractures, Bone', 'Obesity-include-Malnutrition', 'Myalgia-increase-Death', 'Seizures-linked-Death', 'Neoplasm Metastasis-include-Neoplasms', 'Carcinoma, Hepatocellular-include-Neoplasms', 'Periodontitis-related-Alzheimer Disease', 'Osteoarthritis-become-Pain', 'Musculoskeletal Diseases-pose-Pain', 'Back Pain-considered-Osteomyelitis', 'Back Pain-considered-Fever', 'Cardiac Output, Low-fall-Vision Disorders', 'Back Pain-considered-Nervous System Diseases', 'Osteomyelitis-considered-Fever', 'Osteomyelitis-considered-Nervous System Diseases', 'Alzheimer Disease-accelerated-Hypercholesterolemia', 'Brain Diseases-associated-Acute Kidney Injury', 'Acute Kidney Injury-associated-Brain Diseases', 'Dementia, Vascular-accelerated-Hypercholesterolemia', 'Brain Diseases-reported-Kidney Diseases', 'Camurati-Engelmann Syndrome-remain-Memory Disorders', 'Osteoporosis-associated-Hearing Loss', 'Hearing Loss-associated-Osteoporosis', 'Uterine Cervicitis-followed-Erythema Nodosum', 'Dendritic Cell Sarcoma, Follicular-represent-Hematologic Neoplasms', 'Dendritic Cell Sarcoma, Follicular-manifest-Skin Diseases', 'Hematologic Neoplasms-manifest-Skin Diseases', 'Wounds and Injuries-compare-Spinal Cord Injuries', 'Death-associated-Liver Diseases', 'Liver Diseases-associated-Death', 'Urinary Incontinence-associated-Death', 'Death-associated-Urinary Incontinence', 'Obesity-include-Atrial Fibrillation', 'Hypertension-include-Atrial Fibrillation', 'Diabetes Mellitus-include-Atrial Fibrillation', 'Hypertriglyceridemic Waist-related-Renal Insufficiency, Chronic', 'Coxa Magna-occur-Brain Injuries, Traumatic', 'Neurodegenerative Diseases-include-Nervous System Diseases', 'Prostatic Neoplasms-associated-Neoplasms', 'Neoplasms-associated-Prostatic Neoplasms', 'Renal Insufficiency, Chronic-constituted-Inflammation', 'Hip Fractures-reduce-Death', 'Sarcopenia-associated-Deglutition Disorders', 'Deglutition Disorders-associated-Sarcopenia', 'Sarcopenia-associated-Fibrosis', 'Fibrosis-associated-Sarcopenia', 'Diarrhea-admitted-Pneumonia', 'Drug-Related Side Effects and Adverse Reactions-determined-Death', 'Drug-Related Side Effects and Adverse Reactions-assess-Death', 'Migraine Disorders-manifest-Hyperkinesis', 'Migraine Disorders-manifest-Wounds and Injuries', 'Hip Fractures-reduce-Migraine Disorders', 'Wounds and Injuries-queried-Femoral Fractures', 'Wounds and Injuries-undergo-Femoral Fractures', 'Diabetes Mellitus, Type 2-include-Cardiovascular Diseases', 'Neoplasms-associated-Fatigue', 'Fatigue-associated-Neoplasms', 'Cataract-performed-Alzheimer Disease', 'Malnutrition-assess-Sarcopenia', 'Obesity-reduce-Dementia', 'Death-related-Delirium', 'Dementia-understand-Death', 'Sarcopenia-fall-Cardiac Output, Low', 'Hypotension-increase-Death', 'Weight Loss-increase-Sarcopenia', 'Wounds and Injuries-require-Pain', 'Pain, Postoperative-related-Delirium', 'Xerostomia-involve-Vulvovaginitis', 'Pruritus-involve-Vulvovaginitis', 'Dyspareunia-involve-Vulvovaginitis', 'Dysuria-involve-Vulvovaginitis', 'Infections-involve-Vulvovaginitis', 'Sleep Wake Disorders-associated-Glaucoma', 'Glaucoma-associated-Sleep Wake Disorders', 'Xerostomia-involve-Atrophic Vaginitis', 'Pruritus-involve-Atrophic Vaginitis', 'Dyspareunia-involve-Atrophic Vaginitis', 'Dysuria-involve-Atrophic Vaginitis', 'Infections-involve-Atrophic Vaginitis', 'Asthma-associated-Pulmonary Disease, Chronic Obstructive', 'Pulmonary Disease, Chronic Obstructive-associated-Asthma', 'Lung Neoplasms-associated-Pulmonary Disease, Chronic Obstructive', 'Pulmonary Disease, Chronic Obstructive-associated-Lung Neoplasms', 'Heart Failure-associated-Pulmonary Disease, Chronic Obstructive', 'Pulmonary Disease, Chronic Obstructive-associated-Heart Failure', 'Arrhythmias, Cardiac-evaluate-Atrial Fibrillation', 'Renal Insufficiency, Chronic-associated-Cardiac Output, Low', 'Cardiac Output, Low-associated-Renal Insufficiency, Chronic', 'Arrhythmias, Cardiac-evaluate-Cerebral Infarction', 'Glaucoma-associated-Vision Disorders', 'Vision Disorders-associated-Glaucoma', 'Arrhythmias, Cardiac-evaluate-Heart Failure', 'Arrhythmias, Cardiac-evaluate-Stroke', 'Renal Insufficiency, Chronic-defined-Sarcopenia', 'Alzheimer Disease-associated-Nerve Degeneration', 'Nerve Degeneration-associated-Alzheimer Disease', 'Delirium-focus-Dementia', 'Neurodegenerative Diseases-associated-Nerve Degeneration', 'Nerve Degeneration-associated-Neurodegenerative Diseases', 'Heredodegenerative Disorders, Nervous System-associated-Dementia', 'Dementia-associated-Heredodegenerative Disorders, Nervous System', 'Heredodegenerative Disorders, Nervous System-associated-Stroke', 'Stroke-associated-Heredodegenerative Disorders, Nervous System', 'Ovarian Neoplasms-associate-Endometriosis', 'Endometriosis-associate-Ovarian Neoplasms', 'Coronary Artery Disease-decrease-Dementia', 'Stroke-decrease-Dementia', 'Fasciculation-associated-Fractures, Bone', 'Fractures, Bone-associated-Fasciculation', 'Brain Injuries, Traumatic-lead-Neoplasms', 'Brain Damage, Chronic-caused-Alzheimer Disease', 'Pulmonary Embolism-occur-Death', 'Pneumonia-occur-Death', 'Death-occur-Pneumonia', 'Wounds and Injuries-diagnose-Craniocerebral Trauma', 'Inflammation-contribute-Multiple Organ Failure', 'Inflammation-contribute-Death', 'Inflammation-contribute-HIV Infections', 'Hypothyroidism-associated-Non-alcoholic Fatty Liver Disease', 'Non-alcoholic Fatty Liver Disease-associated-Hypothyroidism', 'Hemangiosarcoma-considered-Blister', 'Hypothyroidism-related-Non-alcoholic Fatty Liver Disease', 'Death-compare-Myocardial Infarction', 'Death-identify-Myocardial Infarction', 'HIV Infections-become-Chronic Disease', 'HIV Infections-become-Death', 'Arrhythmias, Cardiac-related-Diabetes Mellitus, Type 2', 'Cerebral Infarction-find-Dementia', 'Infections-increase-Cardiovascular Diseases', 'Colorectal Neoplasms-selected-Neoplasms', 'Hip Dislocation, Congenital-co-exist-Osteopoikilosis', 'Cerebral Hemorrhage-associated-Death', 'Death-associated-Cerebral Hemorrhage', 'Metabolic Syndrome-occur-Diabetes Mellitus, Type 2', 'Kidney Diseases-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-Kidney Diseases', 'Adrenal Insufficiency-found-Diabetes Mellitus', 'Metabolic Syndrome-found-Diabetes Mellitus', 'Pulmonary Disease, Chronic Obstructive-shown-Death', 'Kidney Diseases-associated-Heart Diseases', 'Heart Diseases-associated-Kidney Diseases', 'Sarcopenia-cause-Death', 'Wounds and Injuries-result-Pain', 'Cardiovascular Diseases-linked-Death', 'Neoplasms-linked-Death', 'Death-offer-Aneurysm', 'Anemia-recognized-Death', 'Neoplasms-outnumber-Brain Neoplasms', 'Femoral Fractures-sustain-Neoplasms', 'Upper Extremity Deformities, Congenital-initiate-Renal Insufficiency', 'Pneumococcal Infections-prevent-Respiratory Tract Diseases', 'Death-related-Lung Neoplasms', 'Lung Neoplasms-obtained-Communicable Diseases', 'Dementia-experience-Delirium', 'Dementia-experience-Hip Fractures', 'Delirium-experience-Hip Fractures', 'Dysbiosis-related-Prostatic Hyperplasia', 'Weight Loss-associated-Dementia', 'Dementia-associated-Weight Loss', 'Weight Loss-associated-Alzheimer Disease', 'Alzheimer Disease-associated-Weight Loss', 'Movement Disorders-associated-Dementia', 'Dementia-associated-Movement Disorders', 'Movement Disorders-associated-Cerebrovascular Disorders', 'Cerebrovascular Disorders-associated-Movement Disorders', 'Movement Disorders-associated-Infections', 'Infections-associated-Movement Disorders', 'Dementia-associated-Headache Disorders, Secondary', 'Headache Disorders, Secondary-associated-Dementia', 'Cerebrovascular Disorders-associated-Headache Disorders, Secondary', 'Headache Disorders, Secondary-associated-Cerebrovascular Disorders', 'Leg Ulcer-treated-Venous Thrombosis', 'Infections-associated-Headache Disorders, Secondary', 'Headache Disorders, Secondary-associated-Infections', 'Movement Disorders-identified-Delirium', 'Movement Disorders-use-Delirium', 'Peripheral Arterial Disease-reduce-Stroke', 'Peripheral Arterial Disease-seem-Death', 'Peripheral Arterial Disease-reduce-Myocardial Infarction', 'Peripheral Arterial Disease-reduce-Hemorrhage', 'Factor XIII Deficiency-modify-Hemorrhage', 'Cardiovascular Diseases-underlie-Atherosclerosis', 'HIV Infections-exposed-Coronary Artery Disease', 'Neutropenia-treat-Leukemia, Myeloid, Acute', 'Thrombocytopenia-treat-Leukemia, Myeloid, Acute', 'Breast Neoplasms-need-Spinal Cord Injuries', 'Pneumonia-treat-Leukemia, Myeloid, Acute', 'Polymyalgia Rheumatica-characterised-Inflammation', 'Inflammation-characterised-Pain', 'Hypertension-undergo-Cataract', 'Parkinson Disease-undergo-Seizures', 'Heart Failure-included-Alzheimer Disease', 'Neoplasms-undergo-Cardiac Complexes, Premature', 'Lewy Body Disease-distinguish-Alzheimer Disease', 'Neoplasms-undergo-Anastomotic Leak', 'Dementia-distinguish-Alzheimer Disease', 'Obesity-used-Myotonic Dystrophy', 'Infections-associated-Deglutition Disorders', 'Deglutition Disorders-associated-Infections', 'Infections-develop-Deglutition Disorders', 'Alzheimer Disease-differ-Basal Ganglia Diseases', 'Alzheimer Disease-differ-Hallucinations', 'Alzheimer Disease-differ-REM Sleep Behavior Disorder', 'Alzheimer Disease-differ-Sleep Wake Disorders', 'Hip Fractures-evaluated-Death', 'Death-cause-Liver Diseases', 'Lewy Body Disease-consist-Dementia', 'Dementia-reveal-Lewy Body Disease', 'Hematoma, Subdural-carry-Death', 'Neurodegenerative Diseases-recognized-Arbovirus Infections', 'Neurodegenerative Diseases-reduce-Death', 'Arbovirus Infections-reduce-Death', 'Alzheimer Disease-related-Diabetes Mellitus', 'Alzheimer Disease-suggest-Hypertension', 'Head and Neck Neoplasms-demonstrate-Infections', 'Diabetes Mellitus-associated-Colorectal Neoplasms', 'Colorectal Neoplasms-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-Prostatic Neoplasms', 'Prostatic Neoplasms-associated-Diabetes Mellitus', 'Seizures-remain-Hematologic Neoplasms', 'Pulmonary Embolism-remain-Death', 'Gait Disorders, Neurologic-characterized-Musculoskeletal Pain', 'Dementia-fall-Cardiac Output, Low', 'Musculoskeletal Pain-include-Gait Disorders, Neurologic', 'Cardiac Output, Low-fall-Chronic Pain', 'Obesity-function-Hip Fractures', 'Sarcopenia-function-Hip Fractures', 'Psychomotor Agitation-found-Alzheimer Disease', 'Myelodysplastic Syndromes-include-Neoplasms', 'Leukemia, Myeloid, Acute-include-Neoplasms', 'Infections-recommended-Cardiovascular Diseases', 'Stroke-follow-Neoplasms', 'Stroke-follow-Diabetes Mellitus', 'Prostatitis-associated-Hyperlipidemias', 'Hyperlipidemias-associated-Prostatitis', 'Death-admitted-Sepsis', 'Diabetes Mellitus-develop-Heart Diseases', 'Stroke-develop-Heart Diseases', 'Stroke-improve-Death', 'Stroke-improve-Heart Failure', 'Femoral Neck Fractures-investigated-Death', 'Ketosis-use-Alzheimer Disease', 'Muscular Diseases-observed-Heart Failure', 'Muscular Diseases-associated-Heart Failure', 'Heart Failure-associated-Muscular Diseases', 'Intestinal Diseases-increase-Infections', 'Renal Insufficiency, Chronic-focus-Death', 'Delirium-remain-Death', 'Hyperparathyroidism, Primary-mistaken-Dementia', 'Fatigue-estimate-Pain', 'Inflammation-acquire-Infections', 'Pain-estimate-Arthritis, Rheumatoid', 'Chronic Pain-compare-Pain', 'Myelodysplastic Syndromes-obtain-Drug-Related Side Effects and Adverse Reactions', 'Chronic Pain-tend-Pain', 'Atrial Fibrillation-lead-Death', 'Diabetes Mellitus-include-Metabolic Diseases', 'Arrhythmias, Cardiac-lead-Death', 'Hypertension-include-Metabolic Diseases', 'Cerebral Infarction-carry-Coma', 'Hepatitis B-include-Hepatitis, Viral, Human', 'Carcinoma, Hepatocellular-related-Hepatitis B', 'Carcinoma, Hepatocellular-related-Arbovirus Infections', 'Diabetes Mellitus-share-Metabolic Diseases', 'Carcinoma, Hepatocellular-collected-Hepatitis B', 'Carcinoma, Hepatocellular-collected-Chemical and Drug Induced Liver Injury', 'Death-collected-Hepatitis B', 'Death-collected-Chemical and Drug Induced Liver Injury', 'Pain-reduce-Osteoarthritis', 'Venous Thromboembolism-predict-Hip Fractures', 'Sarcopenia-correlate-Obesity', 'Sarcopenia-correlate-Fractures, Bone', 'Hip Fractures-selected-Thrombosis', 'Venous Thromboembolism-admitted-Wounds and Injuries', 'Endocarditis-present-Death', 'Venous Thromboembolism-selected-Thrombosis', 'Wounds and Injuries-selected-Thrombosis', 'Neurodegenerative Diseases-affect-Alzheimer Disease', 'Neurodegenerative Diseases-affect-Parkinson Disease', 'Neurodegenerative Diseases-affect-Dementia', 'Primary Ovarian Insufficiency-associated-Osteoporosis', 'Osteoporosis-associated-Primary Ovarian Insufficiency', 'Heart Failure-fall-Cardiac Output, Low', 'Diabetes Mellitus, Type 2-increase-Fractures, Bone', 'Subarachnoid Hemorrhage-fall-Cardiac Output, Low', 'Infections-cause-Gastroenteritis', 'Stroke-fall-Cardiac Output, Low', 'Atrial Fibrillation-fall-Cardiac Output, Low', 'Hypotension-fall-Cardiac Output, Low', 'Dyslipidemias-fall-Cardiac Output, Low', 'Adenocarcinoma of Lung-related-Neoplasms', 'Atrial Fibrillation-assess-Coronary Artery Disease', 'Atrial Fibrillation-assess-Communicable Diseases', 'Atrial Fibrillation-assess-Inflammation', 'Diabetes Mellitus-suffer-Ischemia', 'Inflammation-associated-Lung Injury', 'Lung Injury-associated-Inflammation', 'Neoplasms-identify-Carcinoma, Pancreatic Ductal', 'Weight Gain-associated-Death', 'Death-associated-Weight Gain', 'Cough-protect-Pneumonia', 'Aortitis-emphasize-Mastocytosis, Systemic', 'Infections-defined-Death', 'Sleep Initiation and Maintenance Disorders-associated-Alzheimer Disease', 'Alzheimer Disease-associated-Sleep Initiation and Maintenance Disorders', 'Myocardial Infarction-complicated-Shock, Cardiogenic', 'Sleep Initiation and Maintenance Disorders-associated-Dementia', 'Dementia-associated-Sleep Initiation and Maintenance Disorders', 'Shock, Cardiogenic-associated-Death', 'Death-associated-Shock, Cardiogenic', 'Sarcopenia-associated-Anemia', 'Anemia-associated-Sarcopenia', 'Renal Insufficiency, Chronic-associated-Anemia', 'Anemia-associated-Renal Insufficiency, Chronic', 'Periodontitis-caused-Bacterial Infections', 'Periodontitis-modify-Inflammation', 'Inflammation-caused-Bacterial Infections', 'Atrial Fibrillation-cause-Stroke', 'Neoplasms-measure-Hypertrophy', 'Arrhythmias, Cardiac-cause-Stroke', 'HIV Infections-live-Cardiovascular Diseases', 'HIV Infections-live-Neoplasms', 'HIV Infections-live-Diabetes Mellitus', 'Glaucoma-associated-Ocular Hypertension', 'Ocular Hypertension-associated-Glaucoma', 'Glaucoma-associated-Myopia', 'Myopia-associated-Glaucoma', 'Hip Fractures-admitted-Wounds and Injuries', 'Dyspnea-reveal-Lung Diseases, Obstructive', 'Metabolic Syndrome-associated-Periodontitis', 'Periodontitis-associated-Metabolic Syndrome', 'Sarcopenia-linked-Chronic Disease', 'Myalgia-linked-Chronic Disease', 'Diabetes Mellitus-refer-Metabolic Diseases', 'Wounds and Injuries-associated-Fractures, Open', 'Fractures, Open-associated-Wounds and Injuries', 'Arrhythmias, Cardiac-predict-Death', 'Neoplasms-obtained-Ossification of Posterior Longitudinal Ligament', 'Syncope-include-Syncope, Vasovagal', 'Syncope-investigated-Syncope, Vasovagal', 'Liver Diseases-predict-Death', 'Death-follow-Cardiovascular Diseases', 'Tuberculosis-enhance-Diabetes Mellitus', 'Diverticulosis, Colonic-lead-Diverticular Diseases', 'Atrial Fibrillation-represent-Death', 'Fibrosis-slow-Heart Failure', 'Inflammation-slow-Heart Failure', 'Thrombosis-slow-Heart Failure', 'Tendinopathy-caused-Contracture', 'Vision Disorders-describe-Anophthalmos', 'Hypertension-involved-Hypotension', 'Sleep Wake Disorders-associated-Malnutrition', 'Malnutrition-associated-Sleep Wake Disorders', 'Diabetes Mellitus-prevent-HIV Infections', 'HIV Infections-prevent-Diabetes Mellitus', 'Chronic Disease-associated-Dementia', 'Dementia-associated-Chronic Disease', 'Seizures-diagnosed-Epilepsy', 'Asthma-compare-Signs and Symptoms, Respiratory', 'Prostatic Hyperplasia-result-Urinary Bladder Neck Obstruction', 'Nausea-cause-Constipation', 'Vomiting-cause-Constipation', 'Chronic Disease-result-Urinary Bladder Neck Obstruction', 'Crohn Disease-include-Inflammatory Bowel Diseases', 'Restless Legs Syndrome-undergo-Ovarian Diseases', 'Seizures-associated-Gait Disorders, Neurologic', 'Gait Disorders, Neurologic-associated-Seizures', 'Acute Kidney Injury-hospitalize-Critical Illness', 'Sarcopenia-increase-Hip Fractures', 'Acute Kidney Injury-associated-Mitochondrial Diseases', 'Mitochondrial Diseases-associated-Acute Kidney Injury', 'Sarcopenia-prevent-Hip Fractures', 'Hip Fractures-prevent-Sarcopenia', 'Hip Fractures-require-Pain', 'Deglutition Disorders-caused-Dementia', 'Sexual Dysfunction, Physiological-met-Erectile Dysfunction', 'Non-alcoholic Fatty Liver Disease-suggested-Metabolic Syndrome', 'Immunologic Deficiency Syndromes-associated-Metabolic Syndrome', 'Metabolic Syndrome-associated-Immunologic Deficiency Syndromes', 'Sarcopenia-identified-Scleroderma, Systemic', 'Stroke-represent-Cerebral Small Vessel Diseases', 'HIV Infections-reduce-Seizures', 'Coronary Artery Disease-exhibit-Death', 'Atrophy-reflect-Polyneuropathies', 'Coronary Artery Disease-reduce-Fibrosis', 'Low Back Pain-suffer-Intervertebral Disc Degeneration', 'Death-seen-Urologic Neoplasms', 'Constipation-increase-Stroke', 'Diabetes Mellitus, Type 2-cause-Death', 'Death-infect-Infections', 'Hemorrhage-account-Cerebral Infarction', 'Tooth, Impacted-exacerbate-Alzheimer Disease', 'Dementia-associated-Brain Diseases', 'Brain Diseases-associated-Dementia', 'Hypotension-treated-Hypertension', 'Hypertension-treated-Cardiovascular Diseases', 'Diabetes Mellitus-linked-Prediabetic State', 'Sarcopenia-associate-Death', 'Death-associate-Sarcopenia', 'Hyperlipoproteinemia Type II-associated-Atherosclerosis', 'Atherosclerosis-associated-Hyperlipoproteinemia Type II', 'Hyperlipoproteinemia Type II-associated-Hypercholesterolemia', 'Hypercholesterolemia-associated-Hyperlipoproteinemia Type II', 'Delirium-detected-Hip Fractures', 'Diabetes Mellitus-associated-Cerebrovascular Disorders', 'Cerebrovascular Disorders-associated-Diabetes Mellitus', 'Diabetes Mellitus-affect-Ovarian Diseases', 'Cerebrovascular Disorders-associated-Microvascular Angina', 'Microvascular Angina-associated-Cerebrovascular Disorders', 'Cerebrovascular Disorders-affect-Ovarian Diseases', 'Microvascular Angina-affect-Ovarian Diseases', 'Neoplasms-predict-Drug-Related Side Effects and Adverse Reactions', 'Breast Neoplasms-evaluated-Drug-Related Side Effects and Adverse Reactions', 'Breast Neoplasms-treated-Drug-Related Side Effects and Adverse Reactions', 'Neoplasms-predict-Breast Neoplasms', 'Breast Neoplasms-predict-Drug-Related Side Effects and Adverse Reactions', 'Bone Neoplasms-reduce-Osteoporosis', 'HIV Infections-suffer-Pulmonary Disease, Chronic Obstructive', 'Pulmonary Disease, Chronic Obstructive-obtained-Death', 'Death-related-Pulmonary Disease, Chronic Obstructive', 'Vascular Calcification-contribute-Death', 'Vascular Calcification-contribute-Kidney Failure, Chronic', 'Myocardial Infarction-result-Atherosclerosis', 'Myocardial Infarction-result-Rupture', 'Myocardial Infarction-enrolled-Diabetes Mellitus', 'Sepsis-remain-Death', 'Wounds and Injuries-exert-Death', 'Hypotension-show-Heart Failure', 'Hypertension-live-HIV Infections', 'Fractures, Bone-provide-Pain', 'HIV Infections-associated-Hypertension', 'Hypertension-associated-HIV Infections', 'Pain, Postoperative-associated-Neoplasms', 'Neoplasms-associated-Pain, Postoperative', 'Renal Insufficiency, Chronic-represent-Death', 'Hyponatremia-visit-Memory Disorders', 'Aspergillosis, Allergic Bronchopulmonary-complicate-Asthma', 'Aspergillosis, Allergic Bronchopulmonary-complicate-Cystic Fibrosis', 'Prostatic Hyperplasia-include-Prostatitis', 'Prostatic Neoplasms-include-Prostatitis', 'Psychomotor Disorders-predict-Chronic Disease', 'Aneurysm-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-Aneurysm', 'Spondylolysis-show-Lordosis', 'Renal Insufficiency, Chronic-associated-Death', 'Death-associated-Renal Insufficiency, Chronic', 'Renal Insufficiency, Chronic-associated-Acute Kidney Injury', 'Acute Kidney Injury-associated-Renal Insufficiency, Chronic', 'Muscular Atrophy-associated-Sarcopenia', 'Sarcopenia-associated-Muscular Atrophy', 'Mitochondrial Diseases-associated-HIV Infections', 'HIV Infections-associated-Mitochondrial Diseases', 'Neoplasms-exist-Sarcopenia', 'Stenosis, Pulmonary Artery-result-Hypertension, Pulmonary', 'Stenosis, Pulmonary Artery-result-Death', 'Neoplasms-screen-Sarcopenia', 'Atrial Fibrillation-associated-Embolism', 'Embolism-associated-Atrial Fibrillation', 'Stenosis, Pulmonary Artery-associated-Death', 'Death-associated-Stenosis, Pulmonary Artery', 'Pain-underrecognized-Dementia', 'Communicable Diseases-collect-Death', 'Carcinoma, Hepatocellular-associated-Neoplasms', 'Neoplasms-associated-Carcinoma, Hepatocellular', 'Fractures, Bone-report-Pain', 'Delirium-increase-Dementia', 'Death-associated-Heart Failure', 'Heart Failure-associated-Death', 'Hematoma, Subdural-remove-Hematoma', 'Huntington Disease-associated-Death', 'Death-associated-Huntington Disease', 'Huntington Disease-compare-Death', 'Vascular Calcification-analyzed-Coronary Artery Disease', 'Pain-predict-Dementia', 'Fetal Alcohol Spectrum Disorders-characterized-Death', 'Fetal Alcohol Spectrum Disorders-characterized-Abnormalities, Drug-Induced', 'Fetal Alcohol Spectrum Disorders-characterized-Sepsis', 'Sleep Wake Disorders-associated-Chronic Disease', 'Chronic Disease-associated-Sleep Wake Disorders', 'Fetal Alcohol Spectrum Disorders-characterized-Neoplasms', 'Pain-influence-Dementia', 'Pancreatic Neoplasms-rank-Neoplasms', 'Pain-reported-Obesity', 'Albuminuria-associated-Dementia', 'Dementia-associated-Albuminuria', 'Pain-include-Chronic Disease', 'Dementia-investigated-Olfaction Disorders', 'Compartment Syndromes-provide-Pain', 'Compartment Syndromes-provide-Hip Fractures', 'Pain-provide-Hip Fractures', 'Death-occur-Weight Loss', 'Cerebral Infarction-reduce-Heterotaxy Syndrome', 'Atrial Fibrillation-reduce-Heterotaxy Syndrome', 'Infertility, Female-associated-Ovarian Diseases', 'Ovarian Diseases-associated-Infertility, Female', 'Blindness-need-Vision Disorders', 'Heart Diseases-combined-Death', 'Sarcopenia-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-Sarcopenia', 'Epilepsy, Temporal Lobe-demonstrate-Memory Disorders', 'Heart Diseases-compare-Death', 'Heart Diseases-increase-Death', 'Unconsciousness-associated-Craniocerebral Trauma', 'Craniocerebral Trauma-associated-Unconsciousness', 'Diabetes Mellitus-diagnosed-Sarcopenia', 'Hepatic Encephalopathy-associated-Osteoporotic Fractures', 'Osteoporotic Fractures-associated-Hepatic Encephalopathy', 'Arthritis, Rheumatoid-associated-Anemia', 'Anemia-associated-Arthritis, Rheumatoid', 'Diabetes Mellitus-associated-Anemia', 'Anemia-associated-Diabetes Mellitus', 'Neoplasms-associated-Anemia', 'Anemia-associated-Neoplasms', 'Kidney Failure, Chronic-associated-Anemia', 'Anemia-associated-Kidney Failure, Chronic', 'Crohn Disease-compare-Colitis, Ulcerative', 'Radius Fractures-indicate-Fractures, Bone', 'Sensation Disorders-associated-Hearing Loss', 'Hearing Loss-associated-Sensation Disorders', 'Sensation Disorders-hear-Hearing Loss', 'Dementia-associated-Fractures, Bone', 'Fractures, Bone-associated-Dementia', 'Dementia-associated-Stroke', 'Stroke-associated-Dementia', 'Arthritis, Psoriatic-include-Spondylitis, Ankylosing', 'Wounds and Injuries-caused-Occupational Injuries', 'Fractures, Bone-displace-Osteoporosis', 'Venous Thromboembolism-associated-Thromboembolism', 'Thromboembolism-associated-Venous Thromboembolism', 'Alzheimer Disease-related-Neurodegenerative Diseases', 'Alzheimer Disease-influence-Neurodegenerative Diseases', 'Renal Insufficiency, Chronic-favour-Vascular Calcification', 'HIV Infections-end-Acquired Immunodeficiency Syndrome', 'Hypotension-caused-Hypertension', 'Hypotension-caused-Diabetes Mellitus', 'Color Vision Defects-quantify-Cataract', 'Pain-associated-Adrenal Insufficiency', 'Adrenal Insufficiency-associated-Pain', 'Pain-perceive-Adrenal Insufficiency', 'Albuminuria-associated-Stroke', 'Stroke-associated-Albuminuria', 'Albuminuria-associated-Death', 'Death-associated-Albuminuria', 'Obesity-associated-Chronic Pain', 'Chronic Pain-associated-Obesity', 'Fatigue-fall-Cardiac Output, Low', 'HIV Infections-result-Fibrosis', 'Carcinoma, Hepatocellular-result-Fibrosis', 'Carcinoma, Hepatocellular-develop-HIV Infections', 'Carcinoma, Hepatocellular-develop-Carcinogenesis', 'Proteinuria-related-Renal Insufficiency', 'Neoplasms-associated-Coinfection', 'Coinfection-associated-Neoplasms', 'Death-associated-Alzheimer Disease', 'Alzheimer Disease-associated-Death', 'Coinfection-associated-Death', 'Death-associated-Coinfection', 'Multiple Sclerosis-compare-Pain', 'Neuralgia-compare-Pain', 'Neuralgia-compared-Multiple Sclerosis', 'Neuralgia-compared-Pain', 'Multiple Sclerosis-compared-Pain', 'Ulcer-included-Varicose Ulcer', 'Arteriolosclerosis-included-Varicose Ulcer', 'Femoral Neck Fractures-occur-Pain', 'Osteoporotic Fractures-associated-Osteoporosis', 'Osteoporosis-associated-Osteoporotic Fractures', 'Lysosomal Storage Diseases-induce-Mitochondrial Diseases', 'Hip Fractures-compare-Death', 'Venous Thromboembolism-carry-Death', 'Death-associated-Weight Loss', 'Weight Loss-associated-Death', 'Dementia-complicate-Neoplasms', 'Alcoholic Neuropathy-determined-Pain Insensitivity, Congenital', 'Diabetes Mellitus, Type 2-reduce-Cardiovascular Diseases', 'Sleep Deprivation-associated-Death', 'Death-associated-Sleep Deprivation', 'Acute Pain-induce-Spinal Cord Diseases', 'Wounds and Injuries-sustain-Facial Injuries', 'Polymyalgia Rheumatica-occur-Giant Cell Arteritis', 'Musculoskeletal Diseases-occur-Giant Cell Arteritis', 'Death-hospitalized-Respiratory Insufficiency', 'Hereditary Breast and Ovarian Cancer Syndrome-defined-Osteoporosis', 'Stroke-prevent-Atrial Fibrillation', 'Stroke-prevent-Hemorrhage', 'Atrial Fibrillation-prevent-Hemorrhage', 'Leukemia, Lymphoid-evidence-Anemia', 'Fractures, Bone-incorporate-Osteoporosis', 'Fractures, Bone-incorporate-Sarcopenia', 'Fractures, Bone-incorporate-Obesity', 'Neoplasms-report-Respiratory Distress Syndrome', 'Atrial Fibrillation-prevent-Stroke', 'Leukemia, Lymphoid-include-Neoplasms', 'Atrial Fibrillation-warranted-Carotid Stenosis', 'Lymphoma, Mantle-Cell-include-Neoplasms', 'Lymphoma, B-Cell, Marginal Zone-include-Neoplasms', 'Stroke-warranted-Carotid Stenosis', 'HIV Infections-develop-AIDS Arteritis, Central Nervous System', 'Tendon Injuries-divided-Rupture', 'Tendon Injuries-divided-Cumulative Trauma Disorders', 'Parkinson Disease-increase-Respiratory Tract Infections', 'Cardiovascular Diseases-categorize-Obesity', 'Hip Fractures-observed-Obesity', 'Glucose Metabolism Disorders-indicate-Hyperglycemia', 'Cholangiocarcinoma-identified-Neoplasms', 'Vision Disorders-imply-Death', 'Nervous System Diseases-related-Hip Dislocation', 'Nervous System Diseases-related-Femoral Neck Fractures', 'Hip Fractures-live-Death', 'Fractures, Bone-live-Death', 'Brain Injuries, Traumatic-show-Wounds and Injuries', 'Pain, Postoperative-suggest-Osteoporosis', 'Obesity-associated-Diabetes Mellitus, Type 2', 'Diabetes Mellitus, Type 2-associated-Obesity', 'Neoplasms-complete-Headache Disorders, Secondary', 'Neoplasms-complete-Respiratory Distress Syndrome', 'Restless Legs Syndrome-associated-Atherosclerosis', 'Atherosclerosis-associated-Restless Legs Syndrome', 'Diabetes Mellitus-conduct-Diabetes Mellitus, Type 2', 'Dementia-induced-Brain Diseases', 'Alzheimer Disease-compare-Dementia', 'Pneumonia-defined-Cross Infection', 'Restless Legs Syndrome-based-Atherosclerosis', 'Parkinson Disease-develop-Diabetes Mellitus', 'Capillary Leak Syndrome-present-Heart Failure', 'Capillary Leak Syndrome-present-Anemia, Hemolytic', 'Arthritis-associated-Death', 'Death-associated-Arthritis', 'Cataract-associated-Death', 'Death-associated-Cataract', 'Glaucoma-cause-Blindness', 'Arthritis, Rheumatoid-establish-Osteoarthritis', 'Osteoporosis-result-Fractures, Bone', 'Arthritis, Rheumatoid-establish-Pleural Effusion', 'Fractures, Bone-associated-Back Pain', 'Back Pain-associated-Fractures, Bone', 'Paroxysmal Hemicrania-joine-Stroke', 'Paroxysmal Hemicrania-joine-Hemiplegia', 'Paroxysmal Hemicrania-joine-Headache', 'Stroke-include-Delirium', 'Hyponatremia-include-Delirium', 'Mitochondrial Diseases-manifest-Alzheimer Disease', 'Seizures-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-Seizures', 'Dementia-shared-Death', 'Hypertension-represent-Cardiovascular Diseases', 'Hypertension-represent-Coronary Artery Disease', 'Hypertension-represent-Stroke', 'Cerebrovascular Disorders-associated-Death', 'Death-associated-Cerebrovascular Disorders', 'Nervous System Diseases-calculated-Death', 'Renal Insufficiency, Chronic-associated-Kidney Failure, Chronic', 'Kidney Failure, Chronic-associated-Renal Insufficiency, Chronic', 'Hypertension-predict-Death', 'Fractures, Bone-detected-Wounds and Injuries', 'Death-admitted-Hypotension', 'Osteoarthritis-defined-Pain', 'Cartilage Diseases-lead-Osteoarthritis', 'Stroke-focus-Atrial Fibrillation', 'Stroke-recommend-Atrial Fibrillation', 'Alzheimer Disease-avoided-Dementia', 'Alzheimer Disease-coordinate-Dementia', 'Carcinoma, Squamous Cell-register-Neoplasms', 'Death-experience-Wounds and Injuries', 'Delirium-experience-Wounds and Injuries', 'Liver Diseases-represent-Death', 'Liver Diseases-represent-HIV Infections', 'Neoplasms-develop-Tuberculosis', 'Endometrial Neoplasms-associated-Obesity', 'Obesity-associated-Endometrial Neoplasms', 'Stroke-explained-Migraine with Aura', 'Sleep Wake Disorders-associated-Stroke', 'Stroke-associated-Sleep Wake Disorders', 'Wounds and Injuries-address-Hip Fractures', 'Diabetes Mellitus, Type 2-characterized-Dementia', 'Diabetes Mellitus-characterized-Dementia', 'Alzheimer Disease-fall-Cardiac Output, Low', 'Osteoporotic Fractures-fall-Cardiac Output, Low', 'Cardiac Output, Low-fall-Death', 'Sarcopenia-considered-Neoplasms', 'Neoplasms-increase-Death', 'Asthma-associated-Death', 'Death-associated-Asthma', 'Heart Failure, Systolic-associated-Dementia', 'Dementia-associated-Heart Failure, Systolic', 'Heart Failure, Systolic-associated-Alzheimer Disease', 'Alzheimer Disease-associated-Heart Failure, Systolic', 'Heart Failure, Systolic-associated-Dementia, Vascular', 'Dementia, Vascular-associated-Heart Failure, Systolic', 'Hypertension-associated-Dementia, Vascular', 'Dementia, Vascular-associated-Hypertension', 'Infections-associated-Kidney Diseases', 'Kidney Diseases-associated-Infections', 'Breast Neoplasms-linked-Hypertension', 'Calcinosis-associated-Death', 'Death-associated-Calcinosis', 'Lymphoma-include-Death', 'Lymphoma-include-Hodgkin Disease', 'Hodgkin Disease-face-Death', 'Deglutition Disorders-pose-Death', 'Renal Insufficiency-defined-Kidney Diseases', 'Cardiovascular Diseases-become-HIV Infections', 'Obesity-associated-Renal Tubular Transport, Inborn Errors', 'Renal Tubular Transport, Inborn Errors-associated-Obesity', 'Cardiac Output, Low-defined-Sarcopenia', 'Osteoporotic Fractures-undergo-Death', 'Hypoalbuminemia-deteriorate-Cough', 'Hypoalbuminemia-deteriorate-Death', 'Hypoalbuminemia-deteriorate-Pneumonia', 'Atrial Fibrillation-deteriorate-Cough', 'Atrial Fibrillation-deteriorate-Death', 'Atrial Fibrillation-deteriorate-Pneumonia', 'Alzheimer Disease-improve-Dementia', 'Infections-compare-Tuberculosis', 'Obesity-related-Microvascular Angina', 'Aneurysm-decrease-Death', 'Atrial Fibrillation-associated-Heart Failure', 'Heart Failure-associated-Atrial Fibrillation', 'Atrial Fibrillation-associated-Hip Fractures', 'Hip Fractures-associated-Atrial Fibrillation', 'Atrial Fibrillation-undergo-Hip Fractures', 'Hypertension-associated-Heart Failure', 'Heart Failure-associated-Hypertension', 'Hypertension-associated-Hip Fractures', 'Hip Fractures-associated-Hypertension', 'Hypertension-undergo-Hip Fractures', 'Heart Failure-undergo-Hip Fractures', 'Heart Failure-scheduled-Hip Fractures', 'Dementia-understand-Neurodegenerative Diseases', 'Cardiovascular Diseases-followed-Stroke', 'Glucosephosphate Dehydrogenase Deficiency-cause-Anemia, Hemolytic', 'Anemia, Hemolytic-cause-Cardiovascular Diseases', 'Infections-include-Cardiovascular Diseases', 'Discitis-lead-Back Pain', 'Discitis-lead-Musculoskeletal Diseases', 'Discitis-lead-Neurologic Manifestations', 'Delirium-decrease-Ulcer', 'Seizures-associated-Inflammation', 'Inflammation-associated-Seizures', 'Arthritis, Rheumatoid-lead-Joint Diseases', 'Hypotension, Orthostatic-compare-Myocardial Infarction', 'Hypotension, Orthostatic-associated-Myocardial Infarction', 'Myocardial Infarction-associated-Hypotension, Orthostatic', 'Hypotension, Orthostatic-compare-Syncope', 'Hypotension, Orthostatic-associated-Syncope', 'Syncope-associated-Hypotension, Orthostatic', 'Autoimmune Diseases-lead-Joint Diseases', 'Hypotension, Orthostatic-compare-Death', 'Sarcopenia-associated-Arthritis, Rheumatoid', 'Arthritis, Rheumatoid-associated-Sarcopenia', 'Biliary Tract Diseases-rank-Hypertriglyceridemia', 'Pulmonary Disease, Chronic Obstructive-verify-Death', 'Gastrointestinal Diseases-prevent-Musculoskeletal Diseases', 'Scoliosis-participate-Movement Disorders', 'Olfaction Disorders-associate-Dementia', 'Dementia-associate-Olfaction Disorders', 'Olfaction Disorders-associate-Death', 'Death-associate-Olfaction Disorders', 'Aneurysm-influence-Aortic Aneurysm', 'Pain-reduce-Hypercapnia', 'Appendiceal Neoplasms-identified-Neoplasms', 'Appendiceal Neoplasms-diagnose-Neoplasms', 'Hemophilia A-result-Thrombosis', 'Genetic Diseases, X-Linked-result-Thrombosis', 'Hemophilia A-associated-Death', 'Death-associated-Hemophilia A', 'Calcinosis-correlate-Cardiovascular Diseases', 'Appendicitis-associated-Death', 'Death-associated-Appendicitis', 'Olfaction Disorders-associated-Dementia', 'Dementia-associated-Olfaction Disorders', 'Infections-appear-Death', 'Breast Neoplasms-suffer-Vulvovaginitis', 'Infections-appear-Hip Fractures', 'Neoplasms-assess-Fatigue', 'Hip Fractures-treated-Wounds and Injuries', 'Neoplasms-used-Colorectal Neoplasms', 'Neoplasms-identify-Colorectal Neoplasms', 'Neoplasms-affect-Vulvar Neoplasms', 'Neoplasm Metastasis-affect-Vulvar Neoplasms', 'Telangiectasis-known-Angiodysplasia', 'Dementia-reduce-Psychomotor Agitation', 'Telangiectasis-refer-Arteriovenous Malformations', 'Angiodysplasia-refer-Arteriovenous Malformations', 'Hypogonadism-reduce-Obesity', 'Neoplasms-threat-Malnutrition', 'Cerebrovascular Disorders-precede-Alzheimer Disease', 'Sleep Apnea, Obstructive-increase-Cerebral Infarction', 'Neoplasms-validate-Urinary Bladder Neoplasms', 'Aortic Valve Insufficiency-remain-Mitral Valve Insufficiency', 'Delirium-associate-Death', 'Death-associate-Delirium', 'Neurodegenerative Diseases-taken-Cerebral Infarction', 'Neurodegenerative Diseases-influence-Cerebral Infarction', 'Parkinson Disease-include-Progeria', 'Gaucher Disease-feature-Fatty Liver', 'Headache Disorders, Secondary-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-Headache Disorders, Secondary', 'Gaucher Disease-associated-Metabolic Diseases', 'Metabolic Diseases-associated-Gaucher Disease', 'Ocular Hypertension-used-Cataract', 'Ocular Hypertension-replace-Cataract', 'Gaucher Disease-associated-Weight Gain', 'Weight Gain-associated-Gaucher Disease', 'Gaucher Disease-reverted-Weight Gain', 'Metabolic Diseases-reverted-Weight Gain', 'Lupus Erythematosus, Systemic-result-Eye Diseases', 'Communicable Diseases-used-Neoplasms', 'Communicable Diseases-prepare-Neoplasms', 'Dementia-result-Alzheimer Disease', 'Heart Diseases-account-Death', 'Heart Diseases-account-Abnormalities, Drug-Induced', 'Diabetes Mellitus-exhibit-Death', 'Death-account-Abnormalities, Drug-Induced', 'Pulmonary Emphysema-include-Lung Diseases', 'Pneumonia-include-Lung Diseases', 'Death-show-Neoplasms', 'Stomach Diseases-cause-Death', 'Diabetes Mellitus-increase-Dementia', 'Pulmonary Emphysema-associated-Pneumothorax', 'Pneumothorax-associated-Pulmonary Emphysema', 'Heart Diseases-increase-Dementia', 'Sarcopenia-correlate-Hypertension', 'Hyperparathyroidism-associated-Death', 'Death-associated-Hyperparathyroidism', 'Stroke-increase-Dementia', 'Sarcopenia-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-Sarcopenia', 'Sarcopenia-considered-Inflammation', 'Bone Diseases-remove-Fractures, Bone', 'Epilepsy-represent-Nervous System Diseases', 'Infarction-share-Dementia', 'Delirium-undergo-Kidney Failure, Chronic', 'Death-undergo-Kidney Failure, Chronic', 'Myocardial Infarction-reduce-Death', 'Hypertension-reduce-Diabetes Mellitus', 'Death-documented-Hypertension', 'Osteoarthritis-affect-Obesity', 'Ocular Hypertension-modulate-Glaucoma, Open-Angle', 'Cardiovascular Diseases-become-Death', 'Obesity-represented-Infections', 'Ocular Hypertension-associated-Refractive Errors', 'Refractive Errors-associated-Ocular Hypertension', 'Ocular Hypertension-associated-Hypertension', 'Hypertension-associated-Ocular Hypertension', 'Fractures, Bone-reduce-Obesity', 'Hip Fractures-diagnose-Dementia', 'Anemia-identified-Stroke', 'Anemia-identified-Death', 'Inflammatory Bowel Diseases-provide-Death', 'Inflammatory Bowel Diseases-affected-Aneurysm', 'Death-affected-Aneurysm', 'Osteoporosis-associated-Fractures, Bone', 'Fractures, Bone-associated-Osteoporosis', 'Renal Insufficiency, Chronic-associated-Fatigue', 'Fatigue-associated-Renal Insufficiency, Chronic', 'Renal Insufficiency, Chronic-result-Fatigue', 'Heart Diseases-recommended-Death, Sudden, Cardiac', 'Multiple Sclerosis-experience-Neurologic Manifestations', 'Multiple Sclerosis-experience-Cardiac Output, Low', 'Death-compare-Infections', 'Wounds and Injuries-recommend-Fractures, Bone', 'Dermatitis-associated-Urinary Incontinence', 'Urinary Incontinence-associated-Dermatitis', 'HIV Infections-specialized-Communicable Diseases', 'Hypotension, Orthostatic-associated-Dementia', 'Dementia-associated-Hypotension, Orthostatic', 'Hypotension, Orthostatic-develop-Dementia', 'Vascular Calcification-associate-Kidney Failure, Chronic', 'Kidney Failure, Chronic-associate-Vascular Calcification', 'Rib Fractures-carry-Lung Diseases', 'Rib Fractures-ensue-Pain', 'Sarcopenia-progress-Parkinson Disease', 'Communicable Diseases-indicate-Dementia, Vascular', 'Parkinson Disease-found-Inflammation', 'Neurodegenerative Diseases-related-Inflammation', 'Neurodegenerative Diseases-found-Inflammation', 'Carcinoma, Embryonal-include-Neoplasms', 'Teratoma-include-Neoplasms', 'Seminoma-include-Neoplasms', 'Pneumonia, Aspiration-increase-Death', 'Diabetes Mellitus-contribute-Critical Illness', 'Obesity-contribute-Critical Illness', 'Sarcopenia-diagnosed-Ataxia', 'Renal Insufficiency, Chronic-exacerbated-Diabetes Mellitus', 'Hypotension, Orthostatic-remain-Hypertension', 'Death-suffer-Neoplasms', 'Parkinson Disease-pay-Chronic Disease', 'Sexual Dysfunction, Physiological-affected-Parkinson Disease', 'Infections-get-Cardiovascular Diseases', 'Death-operated-Hip Fractures', 'Infections-get-Diabetes Mellitus, Type 2', 'Urinary Incontinence-estimated-Neoplasms', 'Urinary Incontinence-affect-Neoplasms', 'Infections-get-Neoplasms', 'Infections-get-Respiratory Distress Syndrome', 'Infections-get-Kidney Diseases', 'Infections-get-Death', 'Aortic Aneurysm, Abdominal-reduce-Death', 'Diabetes Mellitus-reduce-Obesity', 'Hematologic Neoplasms-require-Multiple Myeloma', 'Hypertension, Pulmonary-reflect-Heart Failure', 'Hypoplastic Left Heart Syndrome-reflect-Heart Failure', 'Fractures, Bone-include-Osteoporotic Fractures', 'Death-recognised-Cardiomyopathy, Dilated', 'Carcinoma, Hepatocellular-increased-Fatty Liver', 'Shoulder Fractures-treated-Hematoma', 'Penile Induration-promote-Fibrosis', 'Penile Induration-trigger-Erectile Dysfunction', 'Diabetes Mellitus-promote-Fibrosis', 'Diabetes Mellitus-trigger-Erectile Dysfunction', 'Wounds and Injuries-promote-Fibrosis', 'Wounds and Injuries-trigger-Erectile Dysfunction', 'Fibrosis-trigger-Erectile Dysfunction', 'Anemia-go-Fatigue', 'Infections-tend-Fractures, Bone', 'Cardiovascular Diseases-avoid-Death', 'Cardiovascular Diseases-avoid-Dementia', 'Hypertension-remain-Cardiovascular Diseases', 'Hypertension-remain-Death', 'Osteoporosis-related-Periodontitis', 'Fasciculation-associated-Polycystic Ovary Syndrome', 'Polycystic Ovary Syndrome-associated-Fasciculation', 'Menopause, Premature-associated-Adrenal Insufficiency', 'Adrenal Insufficiency-associated-Menopause, Premature', 'Pain-related-Musculoskeletal Diseases', 'Muscle Weakness-accelerate-Death', 'Ossification of Posterior Longitudinal Ligament-control-Alzheimer Disease', 'Ossification of Posterior Longitudinal Ligament-control-Lewy Body Disease', 'Ossification of Posterior Longitudinal Ligament-control-Sclerosis', 'Inflammation-used-Neoplasms', 'Ossification of Posterior Longitudinal Ligament-control-Infarction', 'Ossification of Posterior Longitudinal Ligament-control-Cerebral Small Vessel Diseases', 'Breast Neoplasms-develop-Myotonic Dystrophy', 'Osteoarthritis-represent-Neurodegenerative Diseases', 'Osteoarthritis-characterized-Cartilage Diseases', 'Neurodegenerative Diseases-characterized-Cartilage Diseases', 'Sleep Apnea Syndromes-associated-Hypoxia', 'Hypoxia-associated-Sleep Apnea Syndromes', 'Diverticulosis, Colonic-associated-Abdominal Pain', 'Abdominal Pain-associated-Diverticulosis, Colonic', 'Sleep Apnea Syndromes-associated-Inflammation', 'Inflammation-associated-Sleep Apnea Syndromes', 'Mitochondrial Diseases-cause-Neurodegenerative Diseases', 'Mitochondrial Diseases-cause-Neoplasms', 'Mitochondrial Diseases-cause-Metabolic Diseases', 'HIV Infections-arise-Infections', 'Malnutrition-compare-Death', 'Pneumonia-lead-Death', 'Chronic Disease-related-Cardiac Output, Low', 'Kidney Diseases-progress-Diabetes Mellitus', 'Kidney Diseases-accompany-Hypertension', 'Diabetes Mellitus-accompany-Hypertension', 'Lymphoma, B-Cell-constitute-Hodgkin Disease', 'Dementia-remain-Obesity', 'Obesity, Abdominal-associated-Dementia', 'Dementia-associated-Obesity, Abdominal', 'Obesity, Abdominal-increase-Dementia', 'Congenital Microtia-associated-Goldenhar Syndrome', 'Goldenhar Syndrome-associated-Congenital Microtia', 'Fractures, Bone-associated-Pain', 'Pain-associated-Fractures, Bone', 'Renal Insufficiency, Chronic-accompanied-Acidosis', 'Weight Loss-use-Cardiovascular Diseases', 'Bone Diseases-compare-Renal Insufficiency, Chronic', 'Bone Diseases-improve-Renal Insufficiency, Chronic', 'Bone Diseases-compare-Acidosis', 'Cardiovascular Diseases-analyzed-Obesity', 'Cardiovascular Diseases-analyzed-Diabetes Mellitus, Type 2', 'Obesity-aged-Diabetes Mellitus, Type 2', 'Nephrotic Syndrome-enrolled-Kidney Diseases', 'Kidney Diseases-include-Nephrotic Syndrome', 'Inflammation-play-Neurodegenerative Diseases', 'Visceral Pain-associated-Death', 'Death-associated-Visceral Pain', 'Urinary Incontinence-associated-Critical Illness', 'Critical Illness-associated-Urinary Incontinence', 'Hypertension-associated-Critical Illness', 'Critical Illness-associated-Hypertension', 'Neurodegenerative Diseases-result-Radiculopathy', 'Diabetes Mellitus-associated-Critical Illness', 'Critical Illness-associated-Diabetes Mellitus', 'Leukoaraiosis-reflect-Aneurysm', 'Ichthyosiform Erythroderma, Congenital-observed-Skin Diseases', 'Hemarthrosis-caused-Vascular System Injuries', 'Hemorrhage-caused-Vascular System Injuries', 'Glaucoma-associated-Dementia', 'Dementia-associated-Glaucoma', 'Cataract-associated-Dementia', 'Dementia-associated-Cataract', 'Hip Fractures-show-Adrenal Insufficiency', 'Venous Thromboembolism-place-Wounds and Injuries', 'Death-base-Airway Obstruction', 'Death-identify-Airway Obstruction', 'Wounds and Injuries-develop-Venous Thromboembolism', 'Death-associated-Periodontal Diseases', 'Periodontal Diseases-associated-Death', 'Prostatic Neoplasms-include-Death', 'Periodontal Diseases-associated-Neoplasms', 'Neoplasms-associated-Periodontal Diseases', 'Periodontal Diseases-associated-Prostatic Neoplasms', 'Prostatic Neoplasms-associated-Periodontal Diseases', 'Prostatic Neoplasms-include-Neoplasms', 'Periodontitis-induce-Inflammation', 'Chemical and Drug Induced Liver Injury-associate-Emphysema', 'Emphysema-associate-Chemical and Drug Induced Liver Injury', 'Lymphohistiocytosis, Hemophagocytic-associated-Autoimmune Diseases', 'Autoimmune Diseases-associated-Lymphohistiocytosis, Hemophagocytic', 'Fever-accompanied-Exanthema', 'Fever-accompanied-Fatigue', 'Fever-accompanied-Anorexia', 'Fever-develop-Shock', 'Cardiovascular Diseases-mediated-Inflammation', 'Alzheimer Disease-associated-Chronic Periodontitis', 'Chronic Periodontitis-associated-Alzheimer Disease', 'Alzheimer Disease-associated-Tooth Loss', 'Tooth Loss-associated-Alzheimer Disease', 'Alzheimer Disease-determine-Tooth Loss', 'Coronavirus Infections-lead-Respiratory Distress Syndrome', 'Parkinson Disease-experience-Pneumonia', 'Blood Coagulation Disorders-associated-Death', 'Death-associated-Blood Coagulation Disorders', 'Pneumonia-known-Parkinson Disease', 'Fatty Liver-remain-Hepatitis B', 'Fibrosis-associated-Hypertension', 'Hypertension-associated-Fibrosis', 'Fibrosis-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-Fibrosis', 'Fibrosis-associated-Hepatitis B', 'Hepatitis B-associated-Fibrosis', 'Fibrosis-documented-Hepatitis B', 'Fibrosis-related-Hypertension', 'Fibrosis-related-Diabetes Mellitus', 'Fibrosis-related-Hepatitis B', 'Heart Failure-determine-Osteoporosis', 'Dementia-propose-Sleep Wake Disorders', 'Osteoporosis-become-Osteoporotic Fractures', 'Malnutrition-report-Pain', 'Tuberculosis-obtained-Communicable Diseases', 'Tuberculosis-fall-Cardiac Output, Low', 'Sleep Wake Disorders-considered-Dementia', 'Sarcopenia-generalize-Death', 'Fasciculation-generalize-Death', 'Pneumonia-result-Death', 'Arthralgia-characterize-Arthritis', 'Renal Insufficiency, Chronic-undergo-Bone Diseases', 'Dementia-include-Nervous System Diseases', 'Ossification of Posterior Longitudinal Ligament-display-Atrophy', 'Dementia-recruited-Alzheimer Disease', 'Sleep Apnea Syndromes-associated-Atrial Fibrillation', 'Atrial Fibrillation-associated-Sleep Apnea Syndromes', 'Sleep Apnea Syndromes-associated-Atrial Flutter', 'Atrial Flutter-associated-Sleep Apnea Syndromes', 'Cardiotoxicity-reported-Breast Neoplasms', 'Atrial Flutter-associated-Cheyne-Stokes Respiration', 'Cheyne-Stokes Respiration-associated-Atrial Flutter', 'Obesity-defined-Sarcopenia', 'Acute Kidney Injury-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-Acute Kidney Injury', 'Sleep Initiation and Maintenance Disorders-associated-Pain', 'Pain-associated-Sleep Initiation and Maintenance Disorders', 'Memory Disorders-increase-Alzheimer Disease', 'Progeria-characterized-Arthritis', 'Deglutition Disorders-suffer-Stroke', 'Progeria-characterized-Atherosclerosis', 'Deglutition Disorders-suffer-Head and Neck Neoplasms', 'Deglutition Disorders-suffer-Neurodegenerative Diseases', 'Leukemia, Myelogenous, Chronic, BCR-ABL Positive-quantified-Renal Insufficiency, Chronic', 'Polycystic Ovary Syndrome-manifest-Headache Disorders, Secondary', 'Delirium-use-Dementia', 'Delirium-impair-Mitochondrial Diseases', 'Dementia-impair-Mitochondrial Diseases', 'Corneal Diseases-induced-Diabetes Mellitus', 'Intellectual Disability-combine-Diabetes Mellitus', 'Dementia-include-Diabetes Mellitus', 'Dysarthria-seen-Stroke', 'Aphasia-seen-Stroke', 'Diabetes Mellitus-divided-Hypotension', 'HIV Infections-classified-Death', 'Hypotension-vary-Diabetes Mellitus', 'HIV Infections-classified-Drug Overdose', 'Musculoskeletal Diseases-characterised-Bone Diseases', 'Musculoskeletal Diseases-characterised-Fractures, Bone', 'Musculoskeletal Diseases-characterised-Pain', 'Ischemia-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-Ischemia', 'Obesity-predispose-Fractures, Bone', 'Fractures, Bone-suffer-Sarcopenia', 'Dysarthria-identify-Stroke', 'Hyperlipidemias-see-Atherosclerosis', 'Hyperlipidemias-see-Cardiovascular Diseases', 'Endocarditis-associate-Death', 'Death-associate-Endocarditis', 'Dementia, Vascular-considered-Cerebral Small Vessel Diseases', 'Dementia-considered-Cerebral Small Vessel Diseases', 'Respiratory Tract Diseases-estimated-Death', 'Sarcopenia-assess-Neoplasms', 'Pain-caused-Fractures, Bone', 'Coxa Valga-associated-Cerebral Palsy', 'Cerebral Palsy-associated-Coxa Valga', 'Coxa Valga-associated-Myelodysplastic Syndromes', 'Myelodysplastic Syndromes-associated-Coxa Valga', 'Sarcopenia-exist-Neoplasms', 'Diabetes Mellitus-show-Fibrosis', 'Death-compare-Abdominal Pain', 'Hypogonadism-associated-Postoperative Complications', 'Postoperative Complications-associated-Hypogonadism', 'Hypogonadism-associated-Infections', 'Infections-associated-Hypogonadism', 'Hypogonadism-associated-Venous Thrombosis', 'Venous Thrombosis-associated-Hypogonadism', 'Hypogonadism-associated-Joint Dislocations', 'Joint Dislocations-associated-Hypogonadism', 'Inflammation-considered-Stomach Neoplasms', 'Obesity-increase-Diabetes Mellitus', 'Fractures, Bone-include-Facial Nerve Injuries', 'Wounds and Injuries-include-Facial Nerve Injuries', 'Fractures, Bone-include-Wounds and Injuries', 'Arteriovenous Fistula-show-Huntington Disease', 'Obesity-admitted-Heart Failure', 'Obesity-worsen-Heart Failure', 'Death-complicate-Melanoma', 'Atherosclerosis-confirm-Cardiovascular Diseases', 'Hepatic Encephalopathy-associated-Ascites', 'Ascites-associated-Hepatic Encephalopathy', 'Calcinosis-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-Calcinosis', 'Leukoaraiosis-show-Hemorrhage', 'Leukoaraiosis-show-Intracranial Hemorrhages', 'Leukoaraiosis-associated-Hemorrhage', 'Hemorrhage-associated-Leukoaraiosis', 'Leukoaraiosis-associated-Cerebral Infarction', 'Cerebral Infarction-associated-Leukoaraiosis', 'Neoplasms-diagnosed-Cardiovascular Diseases', 'Diabetes Mellitus-associated-Hemorrhage', 'Hemorrhage-associated-Diabetes Mellitus', 'Diabetes Mellitus-account-Death', 'Hemorrhage-account-Death', 'Carcinoma, Small Cell-include-Nevus, Blue', 'Lymphoma-include-Nevus, Blue', 'Melanoma-include-Nevus, Blue', 'Desmoplastic Small Round Cell Tumor-include-Nevus, Blue', 'Neoplasms-include-Nevus, Blue', 'Aortic Aneurysm, Abdominal-associated-Death', 'Death-associated-Aortic Aneurysm, Abdominal', 'Bone Diseases, Metabolic-sustain-Fractures, Bone', 'Fatigue-reduce-Pain', 'Fatigue-reduce-Chronic Pain', 'Chronic Pain-report-Fatigue', 'Fatigue-associated-Pain', 'Pain-associated-Fatigue', 'Fatigue-associated-Chronic Pain', 'Chronic Pain-associated-Fatigue', 'Olfaction Disorders-used-Parkinson Disease', 'Dyslipidemias-develop-Hyperglycemia', 'Neoplasms-diagnosed-Colorectal Neoplasms', 'Colorectal Neoplasms-analysed-Neoplasms', 'Colorectal Neoplasms-diagnosed-Death', 'Emphysematous Cholecystitis-present-Infections', 'Dermatitis, Atopic-involve-Skin Diseases, Eczematous', 'Dermatitis, Atopic-characterize-Skin Diseases, Eczematous', 'Dermatitis, Atopic-involve-Eczema', 'Skin Diseases, Eczematous-involve-Eczema', 'Cardiovascular Diseases-include-HIV Infections', 'Hypertension-associated-Liver Diseases', 'Liver Diseases-associated-Hypertension', 'Hypertension-underlie-Liver Diseases', 'Adenoma-recommended-Colorectal Neoplasms', 'Neoplasms-recommended-Colorectal Neoplasms', 'Adenoma-recommended-Neoplasms', 'Hypertension-reported-Pain', 'Neoplasms-display-Death', 'Parental Death-complete-Acquired Immunodeficiency Syndrome', 'Osteoporosis-increase-Sarcopenia', 'Sarcopenia-recommended-Pulmonary Disease, Chronic Obstructive', 'Deglutition Disorders-seen-Sarcopenia', 'Nutrition Disorders-seen-Sarcopenia', 'Hypertension-related-Cerebrovascular Disorders', 'Hypertension-associated-Cerebrovascular Disorders', 'Cerebrovascular Disorders-associated-Hypertension', 'Sepsis-suffer-Death', 'Postpartum Hemorrhage-suspected-Fractures, Bone', 'Sepsis-decrease-Death', 'Death-progress-Sepsis', 'Delirium-superimposed-Alzheimer Disease', 'Atrophy-related-Multiple Sclerosis', 'Sarcopenia-cause-Neuromuscular Diseases', 'Inflammation-lead-Dementia', 'Sarcopenia-cause-Heart Failure', 'Aneurysm-lead-Dementia', 'Sarcopenia-characterized-Cardiovascular Abnormalities', 'Dementia-lead-Alzheimer Disease', 'Neuromuscular Diseases-characterized-Cardiovascular Abnormalities', 'Multiple Sclerosis-monitor-Neurodegenerative Diseases', 'Osteoporosis-receive-Fractures, Bone', 'Sarcopenia-combined-Obesity', 'Obesity-associated-Communicable Diseases', 'Communicable Diseases-associated-Obesity', 'Delirium-presented-Dementia', 'Dementia-show-Delirium', 'Vasospasm, Intracranial-differ-Subarachnoid Hemorrhage', 'Diabetes Mellitus-related-Obesity', 'Critical Illness-judged-Dementia', 'Myotonic Dystrophy-associated-Death', 'Death-associated-Myotonic Dystrophy', 'Addison Disease-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-Addison Disease', 'Atrophy-develop-Delirium', 'Neurodegenerative Diseases-include-Alzheimer Disease', 'Neurodegenerative Diseases-associated-Olfaction Disorders', 'Olfaction Disorders-associated-Neurodegenerative Diseases', 'Alzheimer Disease-associated-Olfaction Disorders', 'Olfaction Disorders-associated-Alzheimer Disease', 'Death-related-Colorectal Neoplasms', 'Stroke-account-Cerebral Infarction', 'Dementia-live-Immunologic Deficiency Syndromes', 'Arthritis, Rheumatoid-reported-Death', 'Neonatal Sepsis-cause-Meningitis, Bacterial', 'Delirium-determined-Death', 'Infections-cause-Meningitis, Bacterial', 'Lymphatic Diseases-presented-Fever', 'Lymphatic Diseases-presented-Weight Loss', 'Lymphatic Diseases-presented-Splenomegaly', 'Ocular Hypertension-managed-Glaucoma', 'Dementia-associate-Cardiovascular Diseases', 'Cardiovascular Diseases-associate-Dementia', 'Heart Valve Diseases-affect-Atrial Fibrillation', 'Thromboembolism-affect-Atrial Fibrillation', 'Death-affect-Atrial Fibrillation', 'Fever-compared-Heart Arrest', 'Prostatic Neoplasms-identified-Neoplasms', 'Sleep Wake Disorders-increase-Alzheimer Disease', 'Cerebral Infarction-result-Neurologic Manifestations', 'Anorexia-associated-Sarcopenia', 'Sarcopenia-associated-Anorexia', 'Memory Disorders-develop-Dementia', 'HIV Infections-associated-Tachycardia, Sinus', 'Tachycardia, Sinus-associated-HIV Infections', 'Hematoma-evaluate-Abdominal Pain', 'HIV Infections-associated-Ataxia Telangiectasia', 'Ataxia Telangiectasia-associated-HIV Infections', 'Pancreatitis-associated-Multiple Organ Failure', 'Multiple Organ Failure-associated-Pancreatitis', 'Chronic Disease-fall-Cardiac Output, Low', 'Hypertension-present-Cardiac Complexes, Premature', 'Hematoma-cause-Abdominal Pain', 'Multiple Sclerosis-report-Movement Disorders', 'Seizures-associated-Metabolic Syndrome', 'Metabolic Syndrome-associated-Seizures', 'Seizures-show-Metabolic Syndrome', 'Immunologic Deficiency Syndromes-studied-Osteoporosis', 'Sarcopenia-associated-Lung Diseases', 'Lung Diseases-associated-Sarcopenia', 'Osteoporosis-linked-Lung Diseases', 'Heart Valve Diseases-include-Cardiovascular Diseases', 'Atrial Fibrillation-include-Cardiovascular Diseases', 'Chronic Disease-challenge-Death', 'Necrosis-predict-Heart Failure', 'Death-predict-Dementia', 'Heart Failure-misdiagnosed-Edema', 'Muscle Weakness-related-Fractures, Bone', 'Bone Diseases, Metabolic-related-Fractures, Bone', 'Heart Diseases-associated-Hypotension', 'Hypotension-associated-Heart Diseases', 'Heart Diseases-place-Alzheimer Disease', 'Heart Diseases-place-Neurodegenerative Diseases', 'Hypotension-place-Alzheimer Disease', 'Hypotension-place-Neurodegenerative Diseases', 'Dementia-undergo-Neurodegenerative Diseases', 'Death-undergo-Neurodegenerative Diseases', 'Polymyalgia Rheumatica-characterised-Pain', 'Pain-reduce-Osteoarthritis, Knee', 'Ovarian Neoplasms-use-Neoplasms', 'Ovarian Neoplasms-contain-Neoplasms', 'Anorexia-diagnosed-Esophageal Achalasia', 'Deglutition Disorders-diagnosed-Esophageal Achalasia', 'Weight Loss-diagnosed-Esophageal Achalasia', 'Fractures, Bone-cause-Death', 'Leukemia, Myeloid, Acute-arise-Hematologic Diseases', 'Leukemia, Myeloid, Acute-classified-Hematologic Diseases', 'Death-highlight-Drug Overdose', 'Cardiovascular Diseases-remain-Death', 'Thoracic Injuries-included-Death', 'Brain Injuries, Traumatic-show-Sleep Apnea, Obstructive', 'Brain Injuries, Traumatic-show-Sleep Initiation and Maintenance Disorders', 'Brain Injuries, Traumatic-show-Sleep Wake Disorders', 'Hydrocephalus-affect-Hemorrhage', 'Sarcopenia-met-Parkinsonian Disorders', 'Coronary Artery Disease-include-Communicable Diseases', 'Osteoporotic Fractures-associated-Death', 'Death-associated-Osteoporotic Fractures', 'Peripheral Arterial Disease-include-Communicable Diseases', 'Lung Neoplasms-obtained-Neoplasms', 'Coronary Artery Disease-reduce-Communicable Diseases', 'Peripheral Arterial Disease-reduce-Communicable Diseases', 'Heart Arrest-accord-Acute Kidney Injury', 'Seizures-associated-Ventricular Fibrillation', 'Ventricular Fibrillation-associated-Seizures', 'Obesity-associated-Ventricular Fibrillation', 'Ventricular Fibrillation-associated-Obesity', 'Neurodegenerative Diseases-account-Death', 'Cerebrovascular Disorders-implicated-Alzheimer Disease', 'Takotsubo Cardiomyopathy-considered-Death', 'Sarcopenia-lead-Deglutition Disorders', 'Meningococcal Infections-reduce-Meningitis, Meningococcal', 'Neoplasms-associated-Venous Thrombosis', 'Venous Thrombosis-associated-Neoplasms', 'Sarcopenia-characterized-Muscular Diseases', 'Liver Cirrhosis-associated-Heart Failure', 'Heart Failure-associated-Liver Cirrhosis', 'Eyelid Diseases-accompanied-Hypesthesia', 'Hearing Disorders-cause-Hearing Loss', 'Asthma-based-Signs and Symptoms, Respiratory', 'Wounds and Injuries-identify-Wounds, Nonpenetrating', 'Death-related-Hypotrichosis', 'Pain-identify-Delirium', 'Fibromyalgia-include-Pain', 'Sleep Wake Disorders-associated-Parkinson Disease', 'Parkinson Disease-associated-Sleep Wake Disorders', 'Pain-base-Delirium', 'Osteoporosis-characterized-Fractures, Bone', 'Hypotension, Orthostatic-regarded-Ischemia', 'Atrial Fibrillation-regarded-Ischemia', 'Cardiovascular Diseases-implicated-Multiple Organ Failure', 'Death-cited-HIV Infections', 'HIV Infections-cited-Death', 'Leukoaraiosis-accepted-Cerebral Small Vessel Diseases', 'Leukoaraiosis-associated-Parkinson Disease', 'Parkinson Disease-associated-Leukoaraiosis', 'Constriction, Pathologic-associated-Leukoaraiosis', 'Leukoaraiosis-associated-Constriction, Pathologic', 'Inflammation-associated-Coronary Artery Disease', 'Coronary Artery Disease-associated-Inflammation', 'Sarcopenia-detect-Neoplasms', 'Neoplasms-queried-Hemangiosarcoma', 'Neoplasms-select-Hemangiosarcoma', 'Lip Diseases-followed-Cheilitis', 'Lip Diseases-followed-Aneurysm', 'Neoplasms-understood-Pain', 'Cardiovascular Diseases-investigate-Coronary Artery Disease', 'Neurodegenerative Diseases-culminate-Nerve Degeneration', 'Coronary Artery Disease-include-Cardiovascular Diseases', 'Neoplasms-achieve-Death', 'Dementia-achieve-Death', 'Obesity, Abdominal-predispose-Hyperglycemia', 'Hypotension-associated-Cerebral Infarction', 'Cerebral Infarction-associated-Hypotension', 'Colorectal Neoplasms-affected-Neoplasms', 'Neoplastic Syndromes, Hereditary-affected-Neoplasms', 'HIV Infections-transform-Chronic Disease', 'Arrhythmias, Cardiac-associated-Stroke', 'Stroke-associated-Arrhythmias, Cardiac', 'Death-increase-Fatty Liver', 'Cardiac Output, Low-register-Wounds and Injuries', 'Abnormalities, Drug-Induced-associated-Sarcopenia', 'Sarcopenia-associated-Abnormalities, Drug-Induced', 'Chronic Disease-associated-Sarcopenia', 'Sarcopenia-associated-Chronic Disease', 'Bronchitis-associated-Sarcopenia', 'Sarcopenia-associated-Bronchitis', 'Weight Loss-exacerbate-Sarcopenia', 'Obesity-exacerbate-Sarcopenia', 'Sarcopenia-evaluated-Neoplasms', 'Vision Disorders-associated-Death', 'Death-associated-Vision Disorders', 'Pain-associated-Neuromuscular Junction Diseases', 'Neuromuscular Junction Diseases-associated-Pain', 'Ovarian Hyperstimulation Syndrome-associated-Breast Neoplasms', 'Breast Neoplasms-associated-Ovarian Hyperstimulation Syndrome', 'Ovarian Hyperstimulation Syndrome-follow-Amenorrhea', "Fuchs' Endothelial Dystrophy-referred-Vision Disorders", 'Atrial Fibrillation-increase-Stroke', 'Atrial Fibrillation-increase-Heart Failure', 'Atrial Fibrillation-increase-Death', 'Inflammatory Bowel Diseases-show-Heart Failure', 'Hearing Loss-hear-Mobility Limitation', 'Giant Cell Arteritis-calculate-Death', 'Cholecystitis-followed-Gallbladder Diseases', 'Wounds and Injuries-hospitalised-Brain Injuries, Traumatic', 'Urinary Bladder Neoplasms-yield-Sarcopenia', 'Delirium-undergo-Colorectal Neoplasms', 'Death-increase-Neoplasms', 'Hypertension-include-Heart Failure', 'Coronary Artery Disease-include-Heart Failure', 'Atrial Fibrillation-correlate-Fibrosis', 'Neoplasms-document-Death', 'Neoplasms-document-Gallbladder Neoplasms', 'Patellar Dislocation-referred-Wounds and Injuries', 'Diabetes Mellitus-interact-Cataract', 'Communicable Diseases-influence-Diabetes Mellitus', 'Aneurysm-associated-Death', 'Death-associated-Aneurysm', 'Colorectal Neoplasms-identified-Neoplasms', 'Diabetes Mellitus, Type 2-increase-Dementia', 'Dementia-defined-Headache Disorders, Secondary', 'Chronobiology Disorders-characterized-Sleepiness', 'Pulmonary Disease, Chronic Obstructive-diagnosed-Tuberculosis', 'Ocular Hypertension-affect-Glaucoma', 'Status Epilepticus-associated-Death', 'Death-associated-Status Epilepticus', 'Pain, Postoperative-undergo-Neoplasms', 'Renal Insufficiency-undergo-Osteoporosis', 'Cachexia-defined-Weight Loss', 'Ventricular Premature Complexes-include-Hyperthyroidism', 'Death-undergo-Hip Dislocation, Congenital', 'Intestinal Diseases-termed-Dysbiosis', 'Neoplasms-related-Muscle Weakness', 'Neoplasms-related-Delayed Emergence from Anesthesia', 'Neoplasms-report-Pain', 'Neoplasms-occur-Pain', 'Neoplasms-occur-Fatigue', 'Infections-lead-Death', 'Sarcopenia-worsen-Liver Cirrhosis', 'Osteoporosis-worsen-Liver Cirrhosis', 'Neoplasms-associated-Malnutrition', 'Malnutrition-associated-Neoplasms', 'Fractures, Bone-affect-Osteoporotic Fractures', 'Fractures, Bone-represent-Death', 'Neoplasms-considered-Hernia', 'Adenomatous Polyposis Coli-undergo-Colorectal Neoplasms', 'Adenomatous Polyposis Coli-reduce-Colorectal Neoplasms', 'Adenomatous Polyposis Coli-undergo-Death', 'Adenomatous Polyposis Coli-reduce-Death', 'Meningeal Neoplasms-treated-Death', 'Fractures, Bone-define-Osteoarthritis', 'Infections-divide-Sepsis', 'Hypotension-associated-Kidney Diseases', 'Kidney Diseases-associated-Hypotension', 'HIV Infections-associated-Acquired Immunodeficiency Syndrome', 'Acquired Immunodeficiency Syndrome-associated-HIV Infections', 'HIV Infections-associated-Neoplasms', 'Neoplasms-associated-HIV Infections', 'Acquired Immunodeficiency Syndrome-associated-Neoplasms', 'Neoplasms-associated-Acquired Immunodeficiency Syndrome', 'Inflammation-play-Kidney Diseases', 'Dyspepsia-report-Abdominal Pain', 'Dyspepsia-report-Constipation', 'Dyspepsia-report-Diarrhea', 'Diabetes Mellitus-investigate-Stroke', 'Hypothyroidism-associated-Death', 'Death-associated-Hypothyroidism', 'HIV Infections-suggest-Inflammation', 'Melanosis-appear-Colonic Neoplasms', 'Melanosis-appear-Pigmentation Disorders', 'Colonic Neoplasms-appear-Pigmentation Disorders', 'Melanosis-associated-Neoplasms', 'Neoplasms-associated-Melanosis', 'Hemochromatosis-lead-Joint Diseases', 'Hemochromatosis-cause-Joint Diseases', 'Hemochromatosis-associated-Joint Diseases', 'Joint Diseases-associated-Hemochromatosis', 'Hemochromatosis-suggest-Joint Diseases', 'Tooth Loss-associate-Hypertension', 'Hypertension-associate-Tooth Loss', 'Tooth Loss-associate-Vomiting', 'Vomiting-associate-Tooth Loss', 'Weight Loss-reflect-Alzheimer Disease', 'Hip Fractures-predict-Death', 'Hydrocephalus-characterized-Gait Apraxia', 'Hydrocephalus-characterized-Dementia', 'Hydrocephalus-characterized-Urinary Incontinence', 'Sarcopenia-discussed-Death', 'Sarcopenia-discussed-Diabetes Mellitus, Type 2', 'Peripheral Arterial Disease-experience-Pain', 'Back Pain-experience-Pain', 'Dementia-assess-Cerebral Hemorrhage', 'Vision Disorders-result-Anophthalmos', 'Retinal Diseases-result-Anophthalmos', 'Diabetes Mellitus-linked-Alzheimer Disease', 'Leukoencephalopathies-occur-Parkinson Disease', 'Dyspnea-result-Heart Failure', 'Dyspnea-result-Pulmonary Disease, Chronic Obstructive', 'Osteoarthritis, Hip-follow-Osteoarthritis', 'Chronic Disease-incorporated-HIV Infections', 'Mitochondrial Diseases-incorporated-HIV Infections', 'Cardiovascular Diseases-linked-Dementia', 'Carcinoma, Small Cell-occur-Lung Neoplasms', 'Death-base-Ischemia', 'Death-base-Infections', 'Obesity-influence-Chronic Disease', 'Liver Cirrhosis-result-Liver Failure', 'Fibrosis-result-Liver Failure', 'Mesothelioma-considered-Pleural Effusion', 'Composite Lymphoma-play-Peripheral Nervous System Diseases', 'Sleep Wake Disorders-result-Inflammation', 'Common Cold-result-Inflammation', 'Retinal Neoplasms-reported-Alzheimer Disease', 'Albuminuria-delay-Diabetes Mellitus', 'Death-explained-Dementia', 'Endocarditis-contribute-Death', 'Sclerosis-associated-Alzheimer Disease', 'Alzheimer Disease-associated-Sclerosis', 'Endocarditis-associated-Death', 'Death-associated-Endocarditis', 'Venous Thrombosis-associated-Inflammatory Bowel Diseases', 'Inflammatory Bowel Diseases-associated-Venous Thrombosis', 'Bacterial Infections-associated-Death', 'Death-associated-Bacterial Infections', 'Venous Thrombosis-undergo-Neoplasms', 'Dementia-compare-Periodontal Diseases', 'Inflammatory Bowel Diseases-undergo-Neoplasms', 'Cerebrovascular Disorders-associated-Parkinson Disease', 'Parkinson Disease-associated-Cerebrovascular Disorders', 'Herpes Zoster-correlated-Hypotension', 'Wounds and Injuries-implicated-Pulmonary Fibrosis', 'Diabetes Mellitus-receive-Glaucoma', 'Muscle Hypotonia-receive-Glaucoma', 'Exfoliation Syndrome-receive-Glaucoma', 'Glaucoma-receive-Iris Diseases', 'Atherosclerosis-implicated-Stroke', 'Diabetes Mellitus-integrate-Dementia', 'Cardiovascular Diseases-integrate-Dementia', 'Diabetes Mellitus-result-Dementia', 'Atrial Fibrillation-differ-Thromboembolism', 'Pain-related-Neoplasms', 'Hypertension-refine-Atherosclerosis', 'Sarcopenia-known-Pulmonary Disease, Chronic Obstructive', 'Hypertension-associated-Heart Valve Diseases', 'Heart Valve Diseases-associated-Hypertension', 'Hyperuricemia-related-Heart Failure', 'Dyspepsia-exclude-Hallucinations', 'Gait Disorders, Neurologic-fall-Pulmonary Disease, Chronic Obstructive', 'Hyperuricemia-associated-Heart Failure', 'Heart Failure-associated-Hyperuricemia', 'Cardiac Output, Low-attributed-Psychomotor Disorders', 'Diabetes Mellitus-characterized-Hemorrhage', 'Barth Syndrome-experience-Fatigue', 'Barth Syndrome-experience-Muscle Weakness', 'Colorectal Neoplasms-associated-Death', 'Death-associated-Colorectal Neoplasms', 'Hypogonadism-increase-Obesity', 'Genetic Diseases, X-Linked-characterized-Cardiomyopathies', 'Genetic Diseases, X-Linked-characterized-Neutropenia', 'Genetic Diseases, X-Linked-characterized-Muscular Diseases', 'Fragile X Syndrome-hospitalised-Pain', 'Fractures, Bone-expected-Osteoporosis', 'Seizures-associated-Dementia', 'Dementia-associated-Seizures', 'Fibrosis-increase-Viremia', 'Fibrosis-increase-Carcinoma, Hepatocellular', 'Sleep Wake Disorders-measured-Death', 'Sleep Wake Disorders-follow-Death', 'HIV Infections-affect-AIDS Arteritis, Central Nervous System', 'Obesity-considered-Cardiovascular Diseases', 'Obesity-considered-Death', 'Obesity-considered-Coronary Artery Disease', 'Coronary Artery Disease-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-Coronary Artery Disease', 'Coronary Artery Disease-associated-Hypertension', 'Hypertension-associated-Coronary Artery Disease', 'Coronary Artery Disease-associated-Dyslipidemias', 'Dyslipidemias-associated-Coronary Artery Disease', 'Gait Disorders, Neurologic-decreased-Musculoskeletal Diseases', 'Death-listed-Coronary Artery Disease', 'Sleep Wake Disorders-associated-Memory Disorders', 'Memory Disorders-associated-Sleep Wake Disorders', 'Polyuria-increase-Weight Loss', 'Diabetes Mellitus-predict-Acute Coronary Syndrome', 'Fractures, Bone-follow-Death', 'Colorectal Neoplasms-pose-Diabetes Mellitus, Type 2', 'Cardiac Output, Low-fall-Neoplasms', 'Ventricular Septal Rupture-complicated-Mitral Valve Insufficiency', 'Death-related-Asthma', 'Ventricular Septal Rupture-complicated-Aortic Valve Stenosis', 'Mitral Valve Insufficiency-complicated-Ductus Arteriosus, Patent', 'Ductus Arteriosus, Patent-complicated-Aortic Valve Stenosis', 'Dementia-include-Cardiac Output, Low', 'Dementia-live-Cardiac Output, Low', 'Pneumococcal Infections-remain-Death', 'Dementia-include-Sleep Wake Disorders', 'Dementia-precipitate-Sleep Wake Disorders', 'Acquired Immunodeficiency Syndrome-estimate-Death', 'Deglutition Disorders-identify-Pneumonia', 'Deglutition Disorders-identify-Xerostomia', 'Deglutition Disorders-identify-Halitosis', 'Stroke-use-Cerebral Infarction', 'Stroke-use-Ischemia', 'Seizures-associated-Sarcopenia', 'Sarcopenia-associated-Seizures', 'Lung Neoplasms-associated-Pneumonia', 'Pneumonia-associated-Lung Neoplasms', 'Lung Neoplasms-hospitalised-Pneumonia', 'Lung Neoplasms-associated-Gastroesophageal Reflux', 'Gastroesophageal Reflux-associated-Lung Neoplasms', 'Lung Neoplasms-hospitalised-Gastroesophageal Reflux', 'Stroke-extracted-Death', 'Hyponatremia-increase-Death', 'Asthma-include-Drug Hypersensitivity', 'Hypertension-associated-Leukoencephalopathies', 'Leukoencephalopathies-associated-Hypertension', 'Death-decline-Hypertension', 'Coronary Artery Disease-refer-Myocardial Infarction', 'Critical Illness-refer-Myocardial Infarction', 'Fractures, Bone-include-Musculoskeletal Diseases', 'Memory Disorders-live-HIV Infections', 'Lymphoproliferative Disorders-overlap-Sinusitis', 'Death-reduce-Obesity', 'Status Epilepticus-include-Seizures', 'Atrial Fibrillation-indicate-Cardiomyopathy, Hypertrophic', 'Ovarian Diseases-associated-Polycystic Ovary Syndrome', 'Polycystic Ovary Syndrome-associated-Ovarian Diseases', 'Neoplasms-experience-Drug-Related Side Effects and Adverse Reactions', 'Neoplasms-include-Chronic Disease', 'Carcinoma, Hepatocellular-understand-Neoplasms', 'Low Back Pain-caused-Spondylosis', 'Retinal Degeneration-caused-Metabolic Diseases', 'Atrial Fibrillation-carry-Death', 'Atherosclerosis-reduce-Death', 'Colorectal Neoplasms-adapted-Multiple Chronic Conditions', 'Neoplasms-adapted-Multiple Chronic Conditions', 'Metabolic Syndrome-screened-Diabetes Mellitus', 'Delirium-develop-Dementia', 'Heart Failure-include-Atrial Fibrillation', 'Diabetes Mellitus-identified-Colorectal Neoplasms', 'Parkinson Disease-recruited-Parkinson Disease, Secondary', 'Neoplasms-screen-Chronic Disease', 'Colorectal Neoplasms-screen-Chronic Disease', 'Dry Eye Syndromes-reported-Xerostomia', 'Idiopathic Pulmonary Fibrosis-include-Lung Diseases, Interstitial', 'Heart Failure-follow-Cerebrovascular Disorders', 'Gastroenteritis-follow-Heart Failure', 'HIV Infections-structured-Death', 'Parkinson Disease-associated-Death', 'Death-associated-Parkinson Disease', 'Stroke-include-Diabetes Mellitus', 'Stroke-include-Coronary Artery Disease', 'Stroke-include-Heart Failure', 'Stroke-include-Arterial Occlusive Diseases', 'Death-include-Coronary Artery Disease', 'Death-include-Heart Failure', 'Hearing Loss-associated-Dementia', 'Dementia-associated-Hearing Loss', 'Death-include-Arterial Occlusive Diseases', 'Inflammation-associated-Chronic Disease', 'Chronic Disease-associated-Inflammation', 'Inflammation-associated-Metabolic Diseases', 'Metabolic Diseases-associated-Inflammation', 'Inflammation-range-Metabolic Diseases', 'Inflammation-range-Neoplasms', 'Chronic Disease-range-Metabolic Diseases', 'Arthritis, Psoriatic-result-Gaucher Disease', 'Chronic Disease-range-Neoplasms', 'Arthritis, Psoriatic-result-Osteonecrosis', 'Gaucher Disease-result-Osteonecrosis', 'Hearing Loss-associated-Neurodegenerative Diseases', 'Neurodegenerative Diseases-associated-Hearing Loss', 'Hearing Loss-cause-Neurodegenerative Diseases', 'Dementia-cause-Neurodegenerative Diseases', 'Sarcopenia-receive-Nerve Degeneration', 'Dementia-analyzed-Hearing Loss', 'Fatigue-lead-Death', 'Mastocytosis, Systemic-associated-Fractures, Bone', 'Fractures, Bone-associated-Mastocytosis, Systemic', 'Migraine Disorders-include-Headache', 'Migraine Disorders-associated-Dementia', 'Dementia-associated-Migraine Disorders', 'Migraine Disorders-associated-Alzheimer Disease', 'Alzheimer Disease-associated-Migraine Disorders', 'Osteoporosis-predict-Fractures, Bone', 'Dupuytren Contracture-described-Chronic Disease', 'Neoplasms-associated-Meningeal Neoplasms', 'Meningeal Neoplasms-associated-Neoplasms', 'Edema-associated-Meningeal Neoplasms', 'Meningeal Neoplasms-associated-Edema', 'Hypotension-occur-Diabetes Mellitus', 'Death-reduce-Wounds and Injuries', 'Echinococcosis-caused-Infections', 'Infections-caused-Zoonoses', 'Diabetes Mellitus-focused-Death', 'Cardiovascular Diseases-represent-Death', 'Diabetes Mellitus, Type 2-associated-Dementia', 'Dementia-associated-Diabetes Mellitus, Type 2', 'Atherosclerosis-represent-Death', 'Diabetes Mellitus-drive-Obesity', 'Diabetes Mellitus-lead-Heart Diseases', 'Fatty Liver-lead-Heart Diseases', 'Kidney Diseases-lead-Heart Diseases', 'Stomach Neoplasms-observed-Death', 'Liver Diseases-treat-Fibrosis', 'Hepatitis C-treat-Fibrosis', 'Death-related-Stroke', 'Obesity-remain-Death', 'Obesity-reduce-Death', 'Stroke-linked-Death', 'Ovarian Diseases-related-Ovarian Neoplasms', 'Huntington Disease-develop-Dementia', 'Huntington Disease-associated-Dementia', 'Dementia-associated-Huntington Disease', 'Dementia-include-Huntington Disease', 'Deglutition Disorders-lead-Pneumonia', 'Deglutition Disorders-lead-Malnutrition', 'Weight Loss-observed-Pulmonary Atresia', 'Deglutition Disorders-lead-Dehydration', 'Galactosemias-develop-Primary Ovarian Insufficiency', 'Fractures, Bone-admitted-Wounds and Injuries', 'Breast Neoplasms-involve-Neoplasms', 'Neoplasms-predict-Death', 'Hypertension-compare-Cardiovascular Diseases', 'Hypertension-compare-Diabetes Mellitus', 'Cardiovascular Diseases-compare-Diabetes Mellitus', 'Myotonic Dystrophy-worsen-Vision Disorders', 'Cardiovascular Diseases-managed-Hypertension', 'Cardiovascular Diseases-managed-Diabetes Mellitus', 'Deglutition Disorders-identified-Death', 'Neoplasms-utilize-Drug-Related Side Effects and Adverse Reactions', 'Cardiovascular Diseases-linked-Hearing Loss', 'Osteoarthritis-included-Sarcopenia', 'Osteoarthritis-suffer-Sarcopenia', 'Sensation Disorders-include-Hearing Loss', 'Inflammation-contribute-Osteoporosis', 'Inflammation-contribute-Fractures, Bone', 'Cachexia-proposed-Malnutrition', 'Heart Failure-focus-Obesity', 'Prostatic Neoplasms-present-Leukoencephalopathies', 'Hip Fractures-lead-Lung Diseases', 'Neuroleptic Malignant Syndrome-used-Parkinson Disease', 'Neuroleptic Malignant Syndrome-distinguish-Parkinson Disease', 'Neuroleptic Malignant Syndrome-used-Parkinson Disease, Secondary', 'Neuroleptic Malignant Syndrome-distinguish-Parkinson Disease, Secondary', 'Neuroleptic Malignant Syndrome-used-Tremor', 'Neuroleptic Malignant Syndrome-distinguish-Tremor', 'Parkinson Disease-distinguish-Parkinson Disease, Secondary', 'Parkinson Disease-distinguish-Tremor', 'Musculoskeletal Diseases-undergo-Spinal Injuries', 'Neuroma, Acoustic-tend-Neoplasms', 'Cataract-associated-Carotid Artery Diseases', 'Carotid Artery Diseases-associated-Cataract', 'Death-serve-Dementia', 'Cerebral Amyloid Angiopathy-mimic-Cerebral Hemorrhage', 'Cerebral Amyloid Angiopathy-mimic-Amyloidosis', 'Skin Neoplasms-meet-Neoplasms', 'Death-identified-Ulcer', 'Death-identified-Peripheral Arterial Disease', 'Neoplasms-used-Meningeal Neoplasms', 'Neoplasms-confirmed-Meningeal Neoplasms', 'Sarcopenia-show-Death', 'Weight Loss-use-Hearing Loss', 'Muscle Weakness-use-Hearing Loss', 'Osteoporosis-use-Hearing Loss', 'Neurologic Manifestations-use-Hearing Loss', 'Fractures, Bone-happen-Osteoporosis', 'Hypertension-associated-Inflammation', 'Inflammation-associated-Hypertension', 'Parkinson Disease-experience-Low Back Pain', 'Hypotension, Orthostatic-considered-Stroke', 'Hypotension, Orthostatic-considered-Dementia', 'Amnesia-fall-Parkinson Disease', 'Malaria-associated-Death', 'Death-associated-Malaria', 'Renal Insufficiency, Chronic-observed-Proteinuria', 'Multiple Sclerosis-increase-Death', 'Delirium-live-Death', 'Dyspnea-caused-Airway Obstruction', 'Hyperuricemia-considered-Cerebral Infarction', 'Dyslipidemias-considered-Cerebral Infarction', 'Paraplegia-occur-Spinal Cord Injuries', 'Supranuclear Palsy, Progressive-characterized-Parkinson Disease, Secondary', 'Nocturia-fall-Cardiac Output, Low', 'Atherosclerosis-staged-Renal Insufficiency, Chronic', 'Atherosclerosis-staged-Kidney Diseases', 'Renal Insufficiency, Chronic-staged-Kidney Diseases', 'Aortic Valve Stenosis-coexist-Diabetes Mellitus', 'HIV Infections-become-Communicable Diseases', 'Acquired Immunodeficiency Syndrome-become-Death', 'Acquired Immunodeficiency Syndrome-become-Communicable Diseases', 'Appendiceal Neoplasms-misdiagnosed-Appendicitis', 'Osteoarthritis-accompanied-Pain', 'Neurodegenerative Diseases-accompanied-Pain', 'Diabetes Mellitus-verified-Neoplasms', 'Diabetes Mellitus-verified-Pancreatic Neoplasms', 'Pancreatitis-verified-Neoplasms', 'Pancreatitis-verified-Pancreatic Neoplasms', 'Fragile X Syndrome-associate-Death', 'Death-associate-Fragile X Syndrome', 'Neoplasms-verified-Pancreatic Neoplasms', 'Death-linked-Kidney Failure, Chronic', 'HIV Infections-decimated-Death', 'Death-related-Acquired Immunodeficiency Syndrome', 'Hearing Disorders-lead-Hearing Loss', 'Osteoarthritis-account-Arthritis', 'Gait Disorders, Neurologic-increase-Dementia', 'Arthritis-account-Osteoarthritis', 'Arthritis-account-Joint Diseases', 'Arthritis-result-Pain', 'Hearing Disorders-associated-Hearing Loss', 'Hearing Loss-associated-Hearing Disorders', 'Hearing Disorders-considered-Hearing Loss', 'Hyperhomocysteinemia-considered-Cardiovascular Diseases', 'Fractures, Bone-exclude-Facial Injuries', 'Liver Cirrhosis-exhibit-Hyperammonemia', 'Foot Ulcer-associated-Atrial Fibrillation', 'Atrial Fibrillation-associated-Foot Ulcer', 'Foot Ulcer-associated-Heart Failure', 'Heart Failure-associated-Foot Ulcer', 'Inflammation-associated-Adrenal Insufficiency', 'Adrenal Insufficiency-associated-Inflammation', 'Thyroid Diseases-associated-Muscle Weakness', 'Muscle Weakness-associated-Thyroid Diseases', 'Signs and Symptoms, Respiratory-predict-Death', 'Musculoskeletal Diseases-caused-Osteoarthritis', 'Polycystic Ovary Syndrome-classified-Obesity', 'Hepatitis E-result-Death', 'Chemical and Drug Induced Liver Injury-result-Death', 'Polycystic Ovary Syndrome-increase-Cardiovascular Diseases', 'Polycystic Ovary Syndrome-increase-Infertility, Female', 'Low Back Pain-include-Chronic Pain', 'Neuralgia-include-Chronic Pain', 'Hemorrhage-occur-Glaucoma', 'Endocrine System Diseases-increase-Cardiovascular Diseases', 'Endocrine System Diseases-increase-Infertility, Female', 'Lung Diseases, Obstructive-associated-Death', 'Death-associated-Lung Diseases, Obstructive', 'Neoplasms-treated-Drug-Related Side Effects and Adverse Reactions', 'Hemorrhage-correlated-Glaucoma', 'Drug-Related Side Effects and Adverse Reactions-suggest-Neoplasms', 'Heart Failure-recognized-Heart Failure, Diastolic', 'Neoplasms-follow-Death', 'Death-cause-Cardiovascular Diseases', 'Death-cause-Neoplasms', 'Cardiovascular Diseases-cause-Neoplasms', 'Pneumonia-remain-Death', 'Pneumonia-live-HIV Infections', 'HIV Infections-decrease-Pneumonia', 'Wounds and Injuries-known-Death', 'Sarcopenia-identify-Alzheimer Disease', 'Diabetes Mellitus, Type 2-compare-Prediabetic State', 'Diabetes Mellitus, Type 2-compare-Glucose Metabolism Disorders', 'Airway Obstruction-provide-Death', 'Deglutition Disorders-associated-Neurodegenerative Diseases', 'Neurodegenerative Diseases-associated-Deglutition Disorders', 'Deglutition Disorders-associated-Chronic Disease', 'Chronic Disease-associated-Deglutition Disorders', 'Cerebral Infarction-caused-Atrial Fibrillation', 'Atrophy-caused-Neurodegenerative Diseases', 'Stroke-caused-Atrial Fibrillation', 'Fractures, Bone-cause-Wounds and Injuries', 'Glaucoma-associated-Obesity', 'Obesity-associated-Glaucoma', 'Glaucoma-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-Glaucoma', 'Sarcopenia-undergo-Lung Neoplasms', 'Lymphoma, B-Cell-presented-Abdominal Pain', 'Lymphoma, B-Cell-presented-Nausea', 'Lymphoma, B-Cell-presented-Vomiting', 'Sarcopenia-characterized-Fasciculation', 'Sepsis-presented-Ovarian Diseases', 'Pain-control-Osteonecrosis', 'Death-collected-Communicable Diseases', 'Prostatic Neoplasms-collected-Communicable Diseases', 'Diabetes Mellitus-compare-Coronary Artery Disease', 'Sleep Initiation and Maintenance Disorders-related-Sleep Wake Disorders', 'Parkinson Disease-related-Sleep Wake Disorders', 'Skin Neoplasms-represent-Neoplasms', 'Sarcopenia-assess-Stroke', 'Neoplasms-develop-Skin Neoplasms', 'Atrial Fibrillation-induced-Fibrosis', 'Atrial Fibrillation-associated-Fibrosis', 'Fibrosis-associated-Atrial Fibrillation', 'Fibrosis-associated-Death', 'Death-associated-Fibrosis', 'Fibrosis-associated-Chronic Disease', 'Chronic Disease-associated-Fibrosis', 'Intracranial Aneurysm-associated-Death', 'Death-associated-Intracranial Aneurysm', 'Rupture-associated-Death', 'Death-associated-Rupture', 'Rib Fractures-admitted-Wounds and Injuries', 'Urinary Incontinence-report-Nocturia', 'Communicable Diseases-affect-Dementia', 'Anemia-shown-Hypertension', 'Anemia-shown-Atherosclerosis', 'Hereditary Breast and Ovarian Cancer Syndrome-include-Musculoskeletal Diseases', 'Pain-include-Musculoskeletal Diseases', 'Pain-show-Parkinson Disease', 'Memory Disorders-attribute-Alzheimer Disease', 'Hereditary Breast and Ovarian Cancer Syndrome-associated-Pain', 'Pain-associated-Hereditary Breast and Ovarian Cancer Syndrome', 'Sarcopenia-characterized-Death', 'Skin Diseases-provide-Acne Vulgaris', 'Death-provide-Hypertension', 'Weight Loss-report-Death', 'Invasive Fungal Infections-cause-Death', 'Invasive Fungal Infections-cause-Leukemia, Myeloid, Acute', 'Death-cause-Leukemia, Myeloid, Acute', 'Delirium-increase-Postoperative Cognitive Complications', 'Death-combined-Neurodegenerative Diseases', 'Supranuclear Palsy, Progressive-follow-Parkinson Disease', 'Alzheimer Disease-follow-Parkinson Disease', 'Fatigue-decrease-Cardiac Output, Low', 'Atrial Fibrillation-reduce-Arrhythmias, Cardiac', 'Osteoarthritis-exacerbated-Pain', 'Musculoskeletal Diseases-exacerbated-Pain', 'Immunologic Deficiency Syndromes-linked-Chronic Disease', 'HIV Infections-found-Lymphopenia', 'Infections-found-Lymphopenia', 'Hypothermia-induce-Blood Coagulation Disorders', 'Hypothermia-increase-Postpartum Hemorrhage', 'Hypothermia-precipitate-Arrhythmias, Cardiac', 'Blood Coagulation Disorders-increase-Postpartum Hemorrhage', 'Blood Coagulation Disorders-precipitate-Arrhythmias, Cardiac', 'Postpartum Hemorrhage-precipitate-Arrhythmias, Cardiac', 'Biliary Tract Diseases-reduce-Gallstones', 'Biliary Tract Diseases-reduce-Pancreatitis', 'Death-lost-Spinal Cord Injuries', 'Death-decreasing-Pancreatic Neoplasms', 'Heart Failure-suggest-Atrial Fibrillation', 'Hydrocephalus-cause-Gait Disorders, Neurologic', 'Brain Injuries, Traumatic-show-Death', 'Diabetes Mellitus-increase-Hepatic Encephalopathy', 'Diabetes Mellitus-increase-Fibrosis', 'Pelvic Neoplasms-considered-Death', 'Peripheral Arterial Disease-associated-Death', 'Death-associated-Peripheral Arterial Disease', 'Urinary Incontinence-define-Fecal Incontinence', 'Genetic Diseases, Inborn-lead-Cardiovascular Diseases', 'Genetic Diseases, Inborn-cause-Death', 'Sarcopenia-predict-Stroke', 'Atrial Fibrillation-cause-Bradycardia', 'Inflammation-associated-Brain Neoplasms', 'Brain Neoplasms-associated-Inflammation', 'Hypertelorism-seen-Hand Deformities, Congenital', 'Precursor Cell Lymphoblastic Leukemia-Lymphoma-include-Neoplasms', 'Spinal Dysraphism-use-Wounds and Injuries', 'Dementia-associated-Aneurysm', 'Aneurysm-associated-Dementia', 'Neoplasms-identify-Drug-Related Side Effects and Adverse Reactions', 'Ocular Motility Disorders-increase-Short Bowel Syndrome', 'Ocular Motility Disorders-increase-Constipation', 'Colonic Neoplasms-increase-Short Bowel Syndrome', 'Colonic Neoplasms-increase-Constipation', 'Lung Diseases-include-Respiratory Tract Diseases', 'Pulmonary Disease, Chronic Obstructive-include-Respiratory Tract Diseases', 'Anomia-recount-Stroke', 'Toothache-prevent-Xerostomia', 'Arbovirus Infections-recognized-Pneumonia', 'Diabetes Mellitus-associated-Hip Fractures', 'Hip Fractures-associated-Diabetes Mellitus', 'Death-conferred-Diabetes Mellitus', 'Death-follow-Hip Fractures', 'Death-decrease-Hip Fractures', 'Diabetes Mellitus-follow-Hip Fractures', 'Diabetes Mellitus-decrease-Hip Fractures', 'Paralysis-contribute-Muscular Dystrophy, Emery-Dreifuss', 'Kidney Diseases-analyzed-Hypertension', 'Muscle Weakness-linked-Neoplasms', 'Muscle Weakness-linked-Death', 'Vision, Low-associate-Hip Fractures', 'Hip Fractures-associate-Vision, Low', 'Vision, Low-associate-Dementia', 'Dementia-associate-Vision, Low', 'Obesity-support-Prostatic Hyperplasia', 'Obesity-support-Hypogonadism', 'Dementia-drawn-Death', 'Glioblastoma-experience-Postoperative Complications', 'Chronic Disease-associated-Osteoarthritis', 'Osteoarthritis-associated-Chronic Disease', 'Neoplasm Metastasis-diagnosed-Neoplasms', 'Neoplasm Metastasis-diagnosed-Lung Neoplasms', 'Chronic Disease-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-Chronic Disease', 'Neoplasm Metastasis-diagnosed-Breast Neoplasms', 'Neoplasm Metastasis-diagnosed-Melanoma', 'Hypertension-elevate-Cardiovascular Diseases', 'Hypertension-elevate-Death', 'Osteoporosis-linked-Malnutrition', 'Pulmonary Disease, Chronic Obstructive-yield-Pneumonia', 'Pulmonary Disease, Chronic Obstructive-yield-Death', 'Wounds and Injuries-preserve-Inflammation', 'Parkinson Disease-produce-Tremor', 'Parkinson Disease-produce-Muscle Rigidity', 'Inflammation-linked-Vascular Calcification', 'Nervous System Diseases-produce-Tremor', 'Nervous System Diseases-produce-Muscle Rigidity', 'Cerebral Infarction-enrol-Intracranial Arteriosclerosis', 'Cerebral Infarction-enrol-Hypertension', 'Signs and Symptoms, Respiratory-increase-Pulmonary Disease, Chronic Obstructive', 'Glucose Intolerance-delay-Diabetes Mellitus', 'Glucose Intolerance-reduce-Cardiovascular Diseases', 'Glucose Intolerance-reduce-Death', 'Osteoporosis-treat-Pain', 'Osteoporosis-benefit-Pain', 'Myocardial Infarction-followed-Cardiovascular Diseases', 'Stroke-followed-Cardiovascular Diseases', 'Leukoencephalopathies-termed-Leukoaraiosis', 'Leukoaraiosis-termed-Microvascular Angina', 'Sarcopenia-lead-Death', 'Demyelinating Diseases-feature-Multiple Sclerosis', 'Demyelinating Diseases-feature-Demyelinating Autoimmune Diseases, CNS', 'Nerve Degeneration-feature-Multiple Sclerosis', 'Nerve Degeneration-feature-Demyelinating Autoimmune Diseases, CNS', 'Venous Thromboembolism-associated-Postpartum Hemorrhage', 'Postpartum Hemorrhage-associated-Venous Thromboembolism', 'Fatigue-associated-Colorectal Neoplasms', 'Colorectal Neoplasms-associated-Fatigue', 'Fatigue-undergo-Colorectal Neoplasms', 'Wounds and Injuries-examined-Brain Injuries, Traumatic', 'HIV Infections-suffer-Neuralgia', 'Wounds and Injuries-complicated-Intracranial Hemorrhages', 'Coma-examined-Brain Injuries, Traumatic', 'HIV Infections-suffer-AIDS-Associated Nephropathy', 'Coma-complicated-Intracranial Hemorrhages', 'Neuralgia-suffer-AIDS-Associated Nephropathy', 'Cardiac Output, Low-fall-Fractures, Bone', 'Neoplasms-related-Infections', 'Alzheimer Disease-quantified-Death', 'Dementia-confound-Delirium', 'Death-related-Sepsis', 'Low Back Pain-include-Pain', 'Inflammation-represent-Alzheimer Disease', 'Inflammation-associated-Alzheimer Disease', 'Alzheimer Disease-associated-Inflammation', 'Inflammatory Bowel Diseases-challenge-Infections', 'Osteoporosis-constitute-Fractures, Bone', 'Seizures-identify-Status Epilepticus', 'Atrioventricular Block-increased-Diabetes Mellitus', 'Osteomyelitis-complicated-Infections', 'Fractures, Bone-leading-Osteoporosis', 'Osteoarthritis-characterized-Hypertrophy', 'Weight Loss-linked-Death', 'Osteoporosis-undergo-Hip Fractures', 'Neurodegenerative Diseases-characterized-Hypertrophy', 'Osteoporosis-undergo-Osteoarthritis, Hip', 'Carcinoma, Basal Cell-treat-Carcinoma, Squamous Cell', 'Neoplasms-include-Skin Diseases', 'Dementia-undergo-Cataract', 'Keratosis, Seborrheic-reduced-Graft vs Host Disease', 'Telangiectasis-reduced-Graft vs Host Disease', 'Skin Neoplasms-reduced-Graft vs Host Disease', 'Chordoma-compared-Neoplasms', 'Hypercalcemia-cause-Nervous System Diseases', 'Hypertension-associated-Urinary Incontinence', 'Urinary Incontinence-associated-Hypertension', 'Hypertension-associated-Neoplasms', 'Neoplasms-associated-Hypertension', 'Coronary Artery Disease-underlie-Cardiovascular Diseases', 'Xerostomia-decrease-Malnutrition', 'Dry Eye Syndromes-affect-Vision Disorders', 'Obesity-associated-Vascular System Injuries', 'Vascular System Injuries-associated-Obesity', 'Atrial Fibrillation-evaluate-Stroke', 'Atrial Fibrillation-evaluate-Hemorrhage', 'Heterotaxy Syndrome-evaluate-Stroke', 'Vision Disorders-impact-Dementia', 'Diabetes Mellitus, Type 2-compare-Diabetes Mellitus', 'Lung Neoplasms-develop-Venous Thrombosis', 'Cardiac Output, Low-fall-Stroke', 'Parkinson Disease-exceed-Nerve Degeneration', 'Venous Thrombosis-enlarged-Neoplasms', 'Dementia-increase-Alzheimer Disease', 'Death-report-Hip Fractures', 'Pneumonia, Pneumocystis-develop-Autoimmune Diseases', 'Movement Disorders-affect-Pain', 'Diabetes Mellitus-followed-Neoplasms', 'Diabetes Mellitus-followed-Hematologic Diseases', 'Diabetes Mellitus-followed-Pulmonary Disease, Chronic Obstructive', 'Diabetes Mellitus-followed-Autoimmune Diseases', 'Diabetes Mellitus-followed-Liver Cirrhosis', 'Diabetes Mellitus-followed-Immunologic Deficiency Syndromes', 'Hypogonadism-associated-Urolithiasis', 'Urolithiasis-associated-Hypogonadism', 'Death-explained-Stroke', 'Death-associated-Hematoma, Subdural, Acute', 'Hematoma, Subdural, Acute-associated-Death', 'Overbite-diagnosed-Diabetes Mellitus', 'Stroke-include-Heredodegenerative Disorders, Nervous System', 'Neurodegenerative Diseases-included-Thoracic Diseases', 'Pulmonary Disease, Chronic Obstructive-lead-Dementia', 'Pulmonary Disease, Chronic Obstructive-associated-Dementia', 'Dementia-associated-Pulmonary Disease, Chronic Obstructive', 'Hip Fractures-assessed-Delirium', 'Delirium-decrease-Hip Fractures', 'Parkinson Disease-make-Gait Disorders, Neurologic', 'Urinary Incontinence, Stress-caused-Muscle Hypertonia', 'Diabetes Mellitus-increase-Cardiac Output, Low', 'Heart Diseases-predict-Death', 'Anemia-associate-Death', 'Death-associate-Anemia', 'Dementia-predict-Death', 'Infections-associated-Anemia', 'Anemia-associated-Infections', 'Chronic Disease-underestimated-Obesity', 'Dementia, Vascular-associated-Death', 'Death-associated-Dementia, Vascular', 'Glioblastoma-evaluated-Drug-Related Side Effects and Adverse Reactions', 'Colorectal Neoplasms-evaluated-Drug-Related Side Effects and Adverse Reactions', 'Renal Insufficiency, Chronic-associated-Hypertension', 'Hypertension-associated-Renal Insufficiency, Chronic', 'Inflammation-associated-Neurodegenerative Diseases', 'Neurodegenerative Diseases-associated-Inflammation', 'Heart Failure-exhibit-Lung Diseases', 'Neoplasms-exhibit-Tuberculosis', 'Neoplasms-screened-Tuberculosis', 'Acute Coronary Syndrome-considered-Hemorrhage', 'Pain-fall-Cardiac Output, Low', 'Femoral Fractures-associated-Death', 'Death-associated-Femoral Fractures', 'Sleep Wake Disorders-play-Alzheimer Disease', 'Dementia-identify-Death', 'Hypocalcemia-related-Respiratory Tract Infections', 'Neoplasm Metastasis-occur-Visceral Pain', 'Osteoporosis-given-Fractures, Bone', 'Death-diagnosed-Colorectal Neoplasms', 'Adenoma-diagnosed-Colorectal Neoplasms', 'Chronic Disease-contribute-Inflammation', 'Polyps-contribute-Inflammation', 'Waterborne Diseases-associated-Death', 'Death-associated-Waterborne Diseases', 'Dementia-associated-Pain', 'Pain-associated-Dementia', 'Drug-Related Side Effects and Adverse Reactions-balance-Multiple Myeloma', 'Dementia-recognise-Pain', 'Pain-misinterpreted-Dementia', 'Wounds and Injuries-fall-Cardiac Output, Low', 'Alzheimer Disease-account-Death', 'Epilepsies, Partial-defined-Seizures', 'Inflammation-termed-Sarcopenia', 'Sleep Initiation and Maintenance Disorders-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-Sleep Initiation and Maintenance Disorders', 'Osteoporotic Fractures-cause-Death', 'Sleep Initiation and Maintenance Disorders-fall-Cardiac Output, Low', 'Diabetes Mellitus-associated-Dementia', 'Dementia-associated-Diabetes Mellitus', 'Dementia-occur-Death', 'Liver Failure-associated-Death', 'Death-associated-Liver Failure', 'Respiratory Tract Diseases-characterized-Signs and Symptoms, Respiratory', 'Pneumothorax-occur-Rupture', 'Pneumothorax-occur-Blister', 'Diabetes Mellitus-characterized-Diabetes Mellitus, Type 1', 'Fractures, Bone-cause-Pain', 'Anastomotic Leak-follow-Neoplasms', 'Anastomotic Leak-result-Death', 'Hypertension-result-Death', 'Diabetes Mellitus-result-Death', 'Adrenal Insufficiency-play-Osteoporosis', 'Infections-induce-Pneumonia', 'Hypertension-increase-Parkinson Disease', 'Pain-associated-Sleep Wake Disorders', 'Sleep Wake Disorders-associated-Pain', 'Nocturia-associated-Sleep Wake Disorders', 'Sleep Wake Disorders-associated-Nocturia', 'Subarachnoid Hemorrhage-admitted-Wounds and Injuries', 'Spinal Injuries-occur-Thoracic Injuries', 'Spinal Injuries-occur-Uterine Cervicitis', 'Wounds and Injuries-diagnosed-Thoracic Injuries', 'Wounds and Injuries-diagnosed-Uterine Cervicitis', 'Uterine Cervicitis-outnumber-Thoracic Injuries', 'Retinal Telangiectasis-used-Neurologic Manifestations', 'Spinal Injuries-move-Wounds and Injuries', 'Hip Fractures-show-Death', 'Sarcopenia-live-Deglutition Disorders', 'Stroke-display-Infarction', 'Stroke-display-Embolism', 'Neoplasms-augmented-Lymphoma', 'Carcinoma, Non-Small-Cell Lung-undergo-Hemorrhage', 'Prostatic Hyperplasia-exhibit-Fractures, Compression', 'Prostatic Hyperplasia-develop-Fractures, Bone', 'Prostatic Hyperplasia-exhibit-Hip Fractures', 'Prostatic Hyperplasia-develop-Hip Fractures', 'Prostatic Hyperplasia-exhibit-Fractures, Bone', 'Fractures, Bone-develop-Hip Fractures', 'Osteoporosis-cause-Hip Fractures', 'Deglutition Disorders-associated-Pneumonia, Aspiration', 'Pneumonia, Aspiration-associated-Deglutition Disorders', 'Cerebral Infarction-increase-Diabetes Mellitus', 'Sarcopenia-represent-Death', 'Dental Caries-associated-Alzheimer Disease', 'Alzheimer Disease-associated-Dental Caries', 'Mouth Diseases-associated-Alzheimer Disease', 'Alzheimer Disease-associated-Mouth Diseases', 'Mouth Diseases-associated-Dementia', 'Dementia-associated-Mouth Diseases', 'Diabetes Mellitus-help-Hypotension', 'Dermatitis, Atopic-decrease-Dendritic Cell Sarcoma, Follicular', 'Seizures-fit-Urinary Incontinence, Stress', 'Inflammation-base-HIV Infections', 'HIV Infections-linked-Inflammation', 'Diabetic Angiopathies-accumulate-Diabetes Mellitus', 'Dysphonia-report-Atrophy', 'Myocardial Infarction-indicate-Coronary Artery Disease', 'Eye Abnormalities-occur-Amyloid Neuropathies', 'Dementia-exhibit-Psychomotor Agitation', 'Atrial Fibrillation-associated-Hemorrhage', 'Hemorrhage-associated-Atrial Fibrillation', 'Erectile Dysfunction-associated-Atherosclerosis', 'Atherosclerosis-associated-Erectile Dysfunction', 'Stroke-include-Nervous System Diseases', 'Inflammation-play-Asthma', 'Neoplasms-remain-Death', 'HIV Infections-experience-Death', 'Sleep Initiation and Maintenance Disorders-suffer-Stroke', 'Glomerulonephritis-show-Kidney Failure, Chronic', 'Glomerulonephritis-show-Lupus Nephritis', 'Spinal Fractures-represent-Fractures, Bone', 'Spinal Fractures-represent-Wounds and Injuries', 'Fractures, Bone-represent-Wounds and Injuries', 'Glomerulonephritis-exhibit-Kidney Failure, Chronic', 'Glomerulonephritis-exhibit-Lupus Nephritis', 'Heart Diseases-associated-Heart Failure', 'Heart Failure-associated-Heart Diseases', 'Stroke-follow-Hypertension', 'Hypertension-follow-Death', 'Sleep Initiation and Maintenance Disorders-associated-Death', 'Death-associated-Sleep Initiation and Maintenance Disorders', 'Inflammation-explain-Osteoarthritis', 'Epilepsy-characterized-Seizures', 'Nervous System Diseases-characterized-Seizures', 'Cerebral Infarction-increase-Fractures, Bone', 'Diabetes Mellitus-increasing-Death', 'Fractures, Bone-associated-Stroke', 'Stroke-associated-Fractures, Bone', 'Diabetes Mellitus-represent-Diabetes Mellitus, Type 2', 'Diabetes Mellitus-associated-Sensation Disorders', 'Sensation Disorders-associated-Diabetes Mellitus', 'Sensation Disorders-associated-Hyperglycemia', 'Hyperglycemia-associated-Sensation Disorders', 'Carcinoma, Transitional Cell-account-Urinary Bladder Neoplasms', 'Adrenal Insufficiency-lead-Bone Neoplasms', 'Adrenal Insufficiency-lead-Fractures, Bone', 'Carcinoma, Transitional Cell-account-Neoplasms', 'Death-protect-Obesity', 'Heart Failure-make-Death', 'Dementia-protect-Obesity', 'Atherosclerosis-associated-Metabolic Syndrome', 'Metabolic Syndrome-associated-Atherosclerosis', 'Urinary Bladder Neoplasms-account-Neoplasms', 'Cardiovascular Diseases-contribute-Death', 'Dementia, Vascular-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-Dementia, Vascular', 'Dementia, Vascular-increasing-Diabetes Mellitus', 'Dementia, Vascular-increasing-Hypertension', 'Dementia, Vascular-associated-Hyperlipidemias', 'Hyperlipidemias-associated-Dementia, Vascular', 'Dementia, Vascular-increasing-Hyperlipidemias', 'Dementia, Vascular-associated-Obesity', 'Obesity-associated-Dementia, Vascular', 'Dementia, Vascular-increasing-Obesity', 'Cholelithiasis-result-Death', 'Stroke-increase-Hemorrhage', 'Cholelithiasis-determined-Pancreatitis', 'Embolism-increase-Hemorrhage', 'Hypertension-assessed-Dementia', 'Pain-associated-Osteoarthritis', 'Osteoarthritis-associated-Pain', 'Polyendocrinopathies, Autoimmune-share-Thrombosis', 'Sleep Initiation and Maintenance Disorders-work-Chronic Disease', 'Hypothalamic Diseases-observed-Alzheimer Disease', 'Bone Neoplasms-observed-Alzheimer Disease', 'Bone Neoplasms-related-Atrophy', 'Bone Neoplasms-related-Hypothalamic Neoplasms', 'Alzheimer Disease-related-Atrophy', 'Alzheimer Disease-related-Hypothalamic Neoplasms', 'Alzheimer Disease-alter-Hypothalamic Diseases', 'Hypothalamic Diseases-contribute-Bone Neoplasms', 'Atrial Fibrillation-experience-Hemorrhage', 'Stomach Neoplasms-induce-Drug-Related Side Effects and Adverse Reactions', 'Alzheimer Disease-recruited-Dementia', 'Cardiomyopathy, Dilated-done-Hemorrhage', 'Ischemia-defined-Pain', 'Ischemia-caused-Vertebrobasilar Insufficiency', 'Pain-defined-Ischemia', 'Vertebrobasilar Insufficiency-defined-Ischemia', 'Pain-associated-Heart Failure', 'Heart Failure-associated-Pain', 'Adrenal Insufficiency-associated-Heart Failure', 'Heart Failure-associated-Adrenal Insufficiency', 'Bradycardia-improve-Heart Failure', 'Bradycardia-used-Heart Failure', 'Ventricular Remodeling-display-Heart Failure', 'Sleep Apnea, Obstructive-identified-Apnea', 'Neurodegenerative Diseases-occur-Parkinson Disease', 'Ulcer-focus-Chronic Disease', 'Cardiovascular Diseases-focus-Chronic Disease', 'Diabetes Mellitus-focus-Chronic Disease', 'Lung Diseases-focus-Chronic Disease', 'Death-become-Lymphoma, Non-Hodgkin', 'Kidney Diseases-focus-Chronic Disease', 'Neurodegenerative Diseases-focus-Chronic Disease', 'Anemia-focus-Chronic Disease', 'Communicable Diseases-focus-Chronic Disease', 'Acute Coronary Syndrome-result-Cardiovascular Diseases', 'Acute Coronary Syndrome-live-Cardiovascular Diseases', 'Malnutrition-focus-Chronic Disease', 'Urinary Incontinence-focus-Chronic Disease', 'Neoplasms-report-Sexual Dysfunction, Physiological', 'Periprosthetic Fractures-associated-Death', 'Death-associated-Periprosthetic Fractures', 'Polyneuropathies-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-Polyneuropathies', 'Alzheimer Disease-recruited-Memory Disorders', 'Chronic Disease-associate-Ischemia', 'Ischemia-associate-Chronic Disease', 'Osteoporosis-increased-HIV Infections', 'Fractures, Bone-increased-HIV Infections', 'Alzheimer Disease-present-Malnutrition', 'Atrophy-present-Headache Disorders, Secondary', 'Alzheimer Disease-present-Headache Disorders, Secondary', 'Idiopathic Pulmonary Fibrosis-present-Fibrosis', 'Anemia, Aplastic-present-Fibrosis', 'Dementia-related-Diabetes Mellitus', 'Syncope-expand-Cardiomyopathies', 'Syncope-expand-Channelopathies', 'Syncope-expand-Epilepsy', 'Osteoarthritis-cause-Pain', 'Chronic Disease-associated-Frailty', 'Frailty-associated-Chronic Disease', 'Death-delay-Intracranial Hemorrhage, Traumatic', 'Hearing Loss-delay-Intracranial Hemorrhage, Traumatic', 'Facial Paralysis-delay-Intracranial Hemorrhage, Traumatic', 'Dementia-combined-Cerebrovascular Disorders', 'Neoplasms-include-Osteoporosis', 'Neoplasms-cope-Osteoporosis', 'Alzheimer Disease-combined-Cerebrovascular Disorders', 'Lewy Body Disease-combined-Cerebrovascular Disorders', 'Retroperitoneal Neoplasms-participate-Sarcoma', 'Cerebrovascular Disorders-related-Cerebral Amyloid Angiopathy', 'Brain Injuries, Traumatic-result-Malformations of Cortical Development', 'Infarction, Middle Cerebral Artery-involve-Edema', 'Cardiac Output, Low-associated-Fractures, Bone', 'Fractures, Bone-associated-Cardiac Output, Low', 'Infarction, Middle Cerebral Artery-involve-Death', 'Infarction-involve-Edema', 'Infarction-involve-Death', 'Neoplasms-detect-Breast Neoplasms', 'Blindness-include-Vision Disorders', 'Gastrointestinal Diseases-defend-Colorectal Neoplasms', 'Death-reported-Heart Failure', 'Cystic Fibrosis-lead-Respiratory Insufficiency', 'Death-reported-Dementia', 'Constipation-defend-Colorectal Neoplasms', 'Death-suffer-Hip Fractures', 'Dementia-undergo-Hip Fractures', 'Inflammatory Bowel Diseases-defend-Colorectal Neoplasms', 'Cystic Fibrosis-lead-Death', 'Death-undergo-Hip Fractures', 'Migraine Disorders-associated-Sleep Wake Disorders', 'Sleep Wake Disorders-associated-Migraine Disorders', 'Genetic Diseases, Inborn-lead-Respiratory Insufficiency', 'Migraine Disorders-associated-Sleep Initiation and Maintenance Disorders', 'Sleep Initiation and Maintenance Disorders-associated-Migraine Disorders', 'Genetic Diseases, Inborn-lead-Death', 'Pneumonia-decide-Death', 'Hyponatremia-occur-Pituitary Neoplasms', 'Stroke-reported-Memory Disorders', 'Coronary Artery Disease-forecast-Death', 'Diabetes Mellitus-diagnosed-Cardiovascular Diseases', 'Vision Disorders-hear-Hearing Loss', 'Dementia-include-Pain', 'Myocardial Infarction-classified-Angina Pectoris', 'Hernia, Diaphragmatic-associated-Signs and Symptoms, Respiratory', 'Signs and Symptoms, Respiratory-associated-Hernia, Diaphragmatic', 'Hearing Loss-produced-Hearing Disorders', 'Tinnitus-produced-Hearing Disorders', 'Hearing Loss, Central-produced-Hearing Disorders', 'Alzheimer Disease-fulfil-Dementia', 'Cerebrovascular Disorders-fulfil-Dementia', 'Gout-increase-Dementia', 'Dry Eye Syndromes-range-Osteoarthritis', 'Infections-used-Endophthalmitis', 'Alzheimer Disease-contribute-Nervous System Diseases', 'Multiple Sclerosis-include-Alzheimer Disease', 'Death-include-Infections', 'Lysosomal Storage Diseases-contribute-Parkinson Disease', 'Death-control-Cardiovascular Diseases', 'Death-assess-Breast Neoplasms', 'Death-assess-Colorectal Neoplasms', 'Dysgeusia-assessed-Neoplasms', 'Dysgeusia-receive-Neoplasms', 'Dysgeusia-occur-Pancreatic Neoplasms', 'Tachycardia, Ventricular-represent-Death', 'Osteoporosis-associated-Inflammation', 'Inflammation-associated-Osteoporosis', 'Dysgeusia-undergo-Neoplasms', 'Disease-associated-Inflammation', 'Inflammation-associated-Disease', 'Autoimmune Diseases-result-Osteoporosis', 'Wounds and Injuries-compare-Hip Fractures', 'Wounds and Injuries-submitted-Hip Fractures', 'Huntington Disease-contribute-Death', 'Brain Injuries, Traumatic-known-Death', 'Prostatic Neoplasms-treated-Prostatic Hyperplasia', 'Prostatic Hyperplasia-identify-Venous Thromboembolism', 'Craniocerebral Trauma-identified-Wounds and Injuries', 'Dementia-estimated-Death', 'Hematoma, Subdural, Acute-admitted-Wounds and Injuries', 'Apnea-associated-Migraine Disorders', 'Migraine Disorders-associated-Apnea', 'Peripheral Arterial Disease-become-Diabetes Mellitus', 'Neuromyelitis Optica-distinguish-Autoimmune Diseases', 'Memory Disorders-associated-Alzheimer Disease', 'Alzheimer Disease-associated-Memory Disorders', 'Cardiovascular Abnormalities-associated-Dementia', 'Dementia-associated-Cardiovascular Abnormalities', 'Osteoporosis-associated-Glycogen Storage Disease Type II', 'Glycogen Storage Disease Type II-associated-Osteoporosis', 'Inflammation-aggravate-Sarcopenia', 'Vision Disorders-ascertained-Cardiac Output, Low', 'Hypertension-evolve-Cardiovascular Diseases', 'Psoriasis-regarded-Mastocytosis, Systemic', 'Peripheral Arterial Disease-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-Peripheral Arterial Disease', 'Metabolic Syndrome-raise-Diabetes Mellitus', 'Wounds and Injuries-predict-Death', 'Coronary Artery Disease-include-Death', 'Cerebral Infarction-include-Death', 'Coronary Artery Disease-include-Heart Arrest', 'Cerebral Infarction-include-Heart Arrest', 'Death-prevent-Cardiac Output, Low', 'Olfaction Disorders-occur-Parkinson Disease', 'Dementia-placed-Alzheimer Disease', 'Dementia-caused-Alzheimer Disease', 'Osteoporotic Fractures-compare-Prostatic Neoplasms', 'Prostatic Neoplasms-associated-Fractures, Bone', 'Fractures, Bone-associated-Prostatic Neoplasms', 'Osteoarthritis-feature-Inflammation', 'Diabetes Mellitus-associated-Postoperative Cognitive Complications', 'Postoperative Cognitive Complications-associated-Diabetes Mellitus', 'Headache Disorders, Secondary-follow-Hip Fractures', 'Headache Disorders, Secondary-experience-Hip Fractures', 'Epilepsy-associated-Coronary Artery Disease', 'Coronary Artery Disease-associated-Epilepsy', 'Obesity-associated-Postoperative Cognitive Complications', 'Postoperative Cognitive Complications-associated-Obesity', 'Hypertension-associated-Postoperative Cognitive Complications', 'Postoperative Cognitive Complications-associated-Hypertension', 'Dementia-defined-Malocclusion', 'Dementia-defined-Alzheimer Disease', 'Keratosis, Actinic-progress-Carcinoma, Squamous Cell', 'Skin Diseases-progress-Carcinoma, Squamous Cell', 'Parkinson Disease, Secondary-introduce-Parkinson Disease', 'Obesity-increase-Adrenal Insufficiency', 'Obesity-associated-Adrenal Insufficiency', 'Adrenal Insufficiency-associated-Obesity', 'Neoplasms-provide-Kidney Neoplasms', 'Death-decrease-Aortic Aneurysm, Abdominal', 'Cataract-remain-Vision Disorders', 'Myocardial Infarction-undergo-Shock, Cardiogenic', 'Death-categorized-Cardiovascular Diseases', 'Death-categorized-Stroke', 'Death-categorized-Neoplasms', 'Death-categorized-Dementia', 'Death-categorized-Infections', 'Death-reduce-Cardiovascular Diseases', 'Death-reduce-Stroke', 'Death-reduce-Kidney Diseases', 'Atherosclerosis-assess-Dystonia', 'Atherosclerosis-assess-Diabetes Mellitus', 'Diabetes Mellitus-undergo-Vascular Calcification', 'Diabetes Mellitus-carry-Death', 'Diabetes Mellitus-associate-Atherosclerosis', 'Atherosclerosis-associate-Diabetes Mellitus', 'Death-associate-Atherosclerosis', 'Atherosclerosis-associate-Death', 'Neoplasms-searched-Melanoma', 'Vascular Calcification-associated-Retinal Diseases', 'Retinal Diseases-associated-Vascular Calcification', 'Vascular Calcification-associated-Nervous System Diseases', 'Nervous System Diseases-associated-Vascular Calcification', 'Vascular Calcification-associated-Calcinosis', 'Calcinosis-associated-Vascular Calcification', 'Diabetes Mellitus-associated-Retinal Diseases', 'Retinal Diseases-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-Nervous System Diseases', 'Nervous System Diseases-associated-Diabetes Mellitus', 'Pulmonary Disease, Chronic Obstructive-increase-Renal Insufficiency, Chronic', 'Sarcopenia-associated-Respiratory Insufficiency', 'Respiratory Insufficiency-associated-Sarcopenia', 'Hypertension-associated-Headache', 'Headache-associated-Hypertension', 'Brain Injuries, Traumatic-develop-Dementia', 'Diabetes Mellitus-identify-Fatigue', 'Diabetes Mellitus-identify-Weight Loss', 'Death-entail-Diabetes Mellitus', 'Cardiovascular Diseases-entail-Diabetes Mellitus', 'Death-use-Atrial Fibrillation', 'Dementia-associated-Brain Injuries, Traumatic', 'Brain Injuries, Traumatic-associated-Dementia', 'Death-half-Atrial Fibrillation', 'Peritoneal Neoplasms-achieve-Death', 'Inflammation-linked-Dementia', 'Hypertension-treat-Syncope', 'Alexander Disease-show-Fibrosis', 'Cardiovascular Diseases-associated-Coronary Artery Disease', 'Coronary Artery Disease-associated-Cardiovascular Diseases', 'Pain-function-Low Back Pain', 'Wounds and Injuries-searched-Death', 'Wounds and Injuries-decrease-Death', 'Microvascular Angina-associated-Dementia', 'Dementia-associated-Microvascular Angina', 'Neurodegenerative Diseases-associated-Dementia', 'Dementia-associated-Neurodegenerative Diseases', 'Somatosensory Disorders-lead-Stomach Neoplasms', 'Somatosensory Disorders-associated-Stenosis, Pulmonary Vein', 'Stenosis, Pulmonary Vein-associated-Somatosensory Disorders', 'Mandibular Nerve Injuries-lead-Stomach Neoplasms', 'Mandibular Nerve Injuries-associated-Stenosis, Pulmonary Vein', 'Stenosis, Pulmonary Vein-associated-Mandibular Nerve Injuries', 'Stomach Neoplasms-associated-Stenosis, Pulmonary Vein', 'Stenosis, Pulmonary Vein-associated-Stomach Neoplasms', 'Cardiac Output, Low-fall-Dementia', 'Prostatic Neoplasms-develop-Obesity', 'Prostatic Neoplasms-develop-Metabolic Syndrome', 'Drug-Related Side Effects and Adverse Reactions-predict-Neoplasms', 'Osteochondritis-associated-Chronic Pain', 'Chronic Pain-associated-Osteochondritis', 'Osteochondritis-associated-Edema', 'Edema-associated-Osteochondritis', 'Contracture-associated-Chronic Pain', 'Chronic Pain-associated-Contracture', 'Contracture-associated-Edema', 'Edema-associated-Contracture', 'Death-related-Alzheimer Disease', 'Low Back Pain-occur-Parkinson Disease', 'Low Back Pain-occur-Pain', 'Obesity-increase-Diverticulitis', 'Parotid Neoplasms-present-Neoplasms', 'Parkinson Disease-inquired-Low Back Pain', 'Parotid Neoplasms-present-Carcinoma, Squamous Cell', 'Parkinson Disease-inquired-Pain', 'Low Back Pain-inquired-Pain', 'Acute Kidney Injury-progress-Renal Insufficiency, Chronic', 'Renal Insufficiency, Chronic-related-Diabetes Mellitus', 'Dementia-increase-Death', 'Dementia-increase-Hip Fractures', 'Death-increase-Hip Fractures', 'Obesity-offer-Hemorrhage', 'Heart Failure-tolerate-Hyperkalemia', 'Rib Fractures-signify-Fractures, Bone', 'Rib Fractures-signify-Death', 'Osteoarthritis-considered-Pain', 'Acute Kidney Injury-compare-Death', 'Renal Insufficiency, Chronic-compare-Death', 'Chronic Disease-associated-Pain', 'Pain-associated-Chronic Disease', 'Hypotension-recognized-Death', 'Hydrocephalus-mimic-Parkinson Disease', 'Hydrocephalus-mimic-Supranuclear Palsy, Progressive', 'Hydrocephalus-mimic-Dementia', 'Focal Nodular Hyperplasia-mimic-Neoplasms', 'Cerebral Small Vessel Diseases-associated-Hypertension', 'Hypertension-associated-Cerebral Small Vessel Diseases', 'Atrophy-related-Alzheimer Disease', 'Seizures-related-Cardiovascular Diseases', 'Psoriasis-associated-Metabolic Syndrome', 'Metabolic Syndrome-associated-Psoriasis', 'Renal Insufficiency, Chronic-include-Acquired Immunodeficiency Syndrome', 'Cardiovascular Diseases-include-Acquired Immunodeficiency Syndrome', 'Glucose Metabolism Disorders-involve-Alzheimer Disease', 'Gout-associated-Hearing Loss', 'Hearing Loss-associated-Gout', 'Diabetes Mellitus, Type 2-associated-Fractures, Bone', 'Fractures, Bone-associated-Diabetes Mellitus, Type 2', 'Hearing Loss-identified-Malocclusion', 'Hearing Loss-include-Sensation Disorders', 'Renal Insufficiency, Chronic-increase-Osteoporosis', 'Nervous System Diseases-observed-Multiple Sclerosis', 'Pulmonary Embolism-associated-Death', 'Death-associated-Pulmonary Embolism', 'Nocturia-result-Polyuria', 'Atrial Fibrillation-share-Cardiovascular Diseases', 'Non-alcoholic Fatty Liver Disease-associated-Atrial Fibrillation', 'Atrial Fibrillation-associated-Non-alcoholic Fatty Liver Disease', 'Non-alcoholic Fatty Liver Disease-share-Cardiovascular Diseases', 'Nervous System Diseases-include-Parkinson Disease', 'Syncope-associated-Death', 'Death-associated-Syncope', 'Heart Diseases-herald-Death', 'Syncope-compare-Death', 'Syncope-herald-Death', 'Nervous System Diseases-include-Dementia', 'Metabolic Syndrome-associated-Alzheimer Disease', 'Alzheimer Disease-associated-Metabolic Syndrome', 'Hearing Loss, Central-known-Hearing Loss, Sudden', 'Death-associated-Glaucoma', 'Glaucoma-associated-Death', 'Delirium-result-Death', 'Diabetes Mellitus, Type 2-associated-Aneurysm', 'Aneurysm-associated-Diabetes Mellitus, Type 2', 'Ocular Hypertension-understand-Glaucoma', 'Bone Neoplasms-associated-Wounds and Injuries', 'Wounds and Injuries-associated-Bone Neoplasms', 'Sarcoma-limited-Drug-Related Side Effects and Adverse Reactions', 'Cholangiocarcinoma-performed-Death', 'Diabetes Mellitus, Type 2-affected-Cardiovascular Diseases', 'Astrocytoma-associated-Hemorrhage', 'Hemorrhage-associated-Astrocytoma', 'Weight Loss-counteract-Obesity', 'Psoriasis-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-Psoriasis', 'Tuberculosis-promote-Calcinosis', 'Death-evaluated-Heart Failure', 'Epilepsy-observed-Onchocerciasis', 'Urogenital Abnormalities-occur-Pain Insensitivity, Congenital', 'Uremia-refer-Kidney Diseases', 'Pain-reduce-Pain Insensitivity, Congenital', 'Alzheimer Disease-followed-Death', 'Fractures, Stress-diagnosed-Pain', 'Radiculopathy-consider-Intervertebral Disc Degeneration', 'Ankle Fractures-treated-Fractures, Bone', 'Death-related-Cerebral Infarction', 'Cerebral Infarction-enrolled-Death', 'Sarcopenia-emerge-Non-alcoholic Fatty Liver Disease', 'Osteoarthritis-manifest-Mitochondrial Diseases', 'Myopia-become-Deaf-Blind Disorders', 'Facial Dermatoses-yield-Pain', 'Vision Disorders-live-Anophthalmos', 'Pneumococcal Infections-prevent-Sepsis', 'Stroke-perform-Mutism', 'Dyspnea-get-Pulmonary Disease, Chronic Obstructive', 'Dementia-related-Stroke', 'Colorectal Neoplasms-associated-Colitis', 'Colitis-associated-Colorectal Neoplasms', 'Pain-contribute-Memory Disorders', 'Drug Hypersensitivity-require-Gingivitis', 'Adrenal Insufficiency-associated-Death', 'Death-associated-Adrenal Insufficiency', 'Seizures-compounds-Fatigue', 'Spinal Cord Injuries-increase-Cardiovascular Diseases', 'Sleep Initiation and Maintenance Disorders-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-Sleep Initiation and Maintenance Disorders', 'Critical Illness-account-Postpartum Hemorrhage', "Infections-placed-Legionnaires' Disease", 'Seizures-associated-Chronic Disease', 'Chronic Disease-associated-Seizures', 'Gout-associated-Osteoporotic Fractures', 'Osteoporotic Fractures-associated-Gout', 'Gout-associated-Rheumatic Fever', 'Rheumatic Fever-associated-Gout', 'Hypertrophy, Left Ventricular-associated-Cerebrovascular Disorders', 'Cerebrovascular Disorders-associated-Hypertrophy, Left Ventricular', 'Gout-associated-Osteoporosis', 'Osteoporosis-associated-Gout', 'Kidney Diseases-associated-Osteoporosis', 'Osteoporosis-associated-Kidney Diseases', 'Kidney Diseases-associated-Fractures, Bone', 'Fractures, Bone-associated-Kidney Diseases', 'Neoplasms-tend-Digestive System Neoplasms', 'Tinnitus-see-Dementia', 'Nervous System Diseases-characterize-Dementia', 'Hematoma, Subdural-include-Alcoholism', 'Hematoma, Subdural-include-Diabetes Mellitus', 'Hematoma, Subdural-include-Arachnoid Cysts', 'Hematoma, Subdural-include-Blood Coagulation Disorders', 'Respiratory Tract Infections-present-Fever', 'Nervous System Diseases-define-Neuralgia', 'Parkinson Disease, Secondary-associated-Dementia', 'Dementia-associated-Parkinson Disease, Secondary', 'Parkinson Disease, Secondary-associated-Hypertension', 'Hypertension-associated-Parkinson Disease, Secondary', 'Cataract-represent-Exfoliation Syndrome', 'Neurodegenerative Diseases-cause-Mitochondrial Diseases', 'Exfoliation Syndrome-represent-Sclerosis', 'Neuralgia-compare-Nervous System Diseases', 'Neuralgia-demonstrate-Nervous System Diseases', 'Sleep Apnea Syndromes-associated-Heart Failure', 'Heart Failure-associated-Sleep Apnea Syndromes', 'Diabetes Mellitus, Type 2-involve-Inflammation', 'HIV Infections-performed-Pulmonary Disease, Chronic Obstructive', 'Pulmonary Disease, Chronic Obstructive-diagnose-Signs and Symptoms, Respiratory', 'Signs and Symptoms, Respiratory-compare-HIV Infections', 'Vascular Calcification-known-Cardiovascular Diseases', 'Vascular Calcification-known-Death', 'Hyponatremia-associated-Fractures, Bone', 'Fractures, Bone-associated-Hyponatremia', 'Pneumonia-reported-Rib Fractures', 'Death-reported-Rib Fractures', 'Pneumonia-occur-Rib Fractures', 'Death-occur-Rib Fractures', 'Weight Loss-predict-Body Weight Changes', 'Obesity-lose-Weight Loss', 'Stroke-enrol-Cerebral Hemorrhage', 'Kidney Neoplasms-associated-Death', 'Death-associated-Kidney Neoplasms', 'Cardiac Output, Low-mediate-Neurodegenerative Diseases', 'Atherosclerosis-determinate-Acute Coronary Syndrome', 'Foot Ulcer-lead-Pain', 'Arthralgia-fill-Pain', 'Chronic Disease-fill-Pain', 'Lipid Metabolism Disorders-related-Diabetes Mellitus', 'Adrenal Insufficiency-define-Xerostomia', 'Iatrogenic Disease-result-Muscle Weakness', 'Iatrogenic Disease-result-Pain', 'Colonic Neoplasms-identified-Neoplasms', 'Gout-associated-Myocardial Infarction', 'Myocardial Infarction-associated-Gout', 'Sepsis-result-Neurologic Manifestations', 'Inflammation-result-Neurologic Manifestations', 'Hypothyroidism-associated-Atherosclerosis', 'Atherosclerosis-associated-Hypothyroidism', 'Sleep Initiation and Maintenance Disorders-remain-Sleep Wake Disorders', 'Sleep Wake Disorders-characterized-Cardiac Output, Low', 'Sleep Wake Disorders-fall-Cardiac Output, Low', 'Stroke-accompanied-Hemorrhage', 'Cerebral Infarction-accompanied-Hemorrhage', 'Anemia-increase-Diabetes Mellitus', 'Death-assess-Coma', 'Paraneoplastic Syndromes-accompanied-Adenocarcinoma', 'Small Cell Lung Carcinoma-accompanied-Adenocarcinoma', 'Inflammation-implicated-Fatigue', 'Diabetes Mellitus-established-Heredodegenerative Disorders, Nervous System', 'Death-base-Pneumonia', 'Sleep Initiation and Maintenance Disorders-associate-Restless Legs Syndrome', 'Restless Legs Syndrome-associate-Sleep Initiation and Maintenance Disorders', 'Weight Loss-create-Short Bowel Syndrome', 'Meningeal Neoplasms-associated-Pain, Postoperative', 'Pain, Postoperative-associated-Meningeal Neoplasms', 'Uremia-remain-Peptic Ulcer', 'Osteoporosis-followed-Hip Fractures', 'Osteoporosis-occur-Hip Fractures', 'Pain-relieve-Ischemia', 'Mitral Valve Insufficiency-worsen-Aortic Valve Stenosis', 'Osteoporosis-followed-Diabetes Mellitus, Type 2', 'Osteoporosis-followed-Hypertension', 'Death-followed-Diabetes Mellitus, Type 2', 'Death-followed-Hypertension', 'Fractures, Open-related-Death', 'Inflammation-investigate-Anemia', 'Inflammation-associated-Anemia', 'Anemia-associated-Inflammation', 'Thyroid Neoplasms-registered-Neoplasms', 'Death-reduced-Neoplasms', 'Musculoskeletal Diseases-increase-Cardiac Output, Low', 'Death-analysed-Neoplasms', 'Death-recorded-Neoplasms', 'Hearing Disorders-exacerbate-Hearing Loss', 'Renal Insufficiency, Chronic-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-Renal Insufficiency, Chronic', 'Breast Neoplasms-satisfy-Desmoplastic Small Round Cell Tumor', 'Breast Neoplasms-satisfy-Oculocerebrorenal Syndrome', 'Pain-undergo-Alcoholism', 'Diabetes Mellitus-confer-Death', 'Bone Neoplasms-require-Fractures, Bone', 'Sleep Wake Disorders-include-Sleep Apnea, Obstructive', 'Sleep Wake Disorders-assess-Sleep Apnea, Obstructive', 'Infections-undergo-Tibial Fractures', 'Obesity-improve-Protein S Deficiency', 'Diabetes Mellitus, Type 2-include-Diabetes Mellitus', 'Anemia-avoid-Drug-Related Side Effects and Adverse Reactions', 'Hemorrhage-interpret-Heart Failure', 'Blood Loss, Surgical-increase-Venous Thrombosis', 'Neoplasms-linked-Carcinoma, Non-Small-Cell Lung', 'Arteriovenous Fistula-compare-Diabetes Mellitus', 'Delirium-studied-Dementia', 'Dementia-develop-Delirium', 'Fractures, Bone-accompain-Neurologic Manifestations', 'Infarction, Middle Cerebral Artery-cause-Neurodegenerative Diseases', 'Neurodegenerative Diseases-cause-Brain Edema', 'Glucose Metabolism Disorders-related-Alzheimer Disease', 'Multiple Sclerosis-report-Neurologic Manifestations', 'Inflammation-improve-Kidney Failure, Chronic', 'Vertebrobasilar Insufficiency-associated-Cerebral Infarction', 'Cerebral Infarction-associated-Vertebrobasilar Insufficiency', 'Vertebrobasilar Insufficiency-associated-Hydrocephalus', 'Hydrocephalus-associated-Vertebrobasilar Insufficiency', 'Hypertension-contribute-Vertebrobasilar Insufficiency', 'Spinal Fractures-associated-Death', 'Death-associated-Spinal Fractures', 'Common Cold-associated-Hearing Loss', 'Hearing Loss-associated-Common Cold', 'Leukemia, Lymphocytic, Chronic, B-Cell-encounter-Drug-Related Side Effects and Adverse Reactions', 'Lymphoma, Non-Hodgkin-encounter-Drug-Related Side Effects and Adverse Reactions', 'Atrial Fibrillation-increase-Chronic Disease', 'Neoplasms-suffer-Drug-Related Side Effects and Adverse Reactions', 'Death-considered-Stomach Neoplasms', 'Hypertension-included-Cardiovascular Diseases', 'Arthritis, Rheumatoid-attributed-Atherosclerosis', 'Leishmaniasis-replicate-Infections', 'Metabolic Syndrome-associated-Communicable Diseases', 'Communicable Diseases-associated-Metabolic Syndrome', 'Sarcopenia-related-Stomach Neoplasms', 'Peripheral Arterial Disease-associated-Fatigue', 'Fatigue-associated-Peripheral Arterial Disease', 'Cerebral Infarction-represent-Cerebral Small Vessel Diseases', 'Acute Coronary Syndrome-range-Pain', 'Neoplasms-used-Chordoma', 'Neoplasms-diagnosed-Chordoma', 'Acute Coronary Syndrome-range-Epilepsy', 'Renal Insufficiency, Chronic-associated-Neoplasms', 'Neoplasms-associated-Renal Insufficiency, Chronic', 'Renal Insufficiency, Chronic-undergo-Neoplasms', 'Pain-range-Epilepsy', 'Death-undergo-Neoplasms', 'Peripheral Nervous System Diseases-associated-Parkinson Disease', 'Parkinson Disease-associated-Peripheral Nervous System Diseases', 'Dementia-related-Parkinson Disease, Secondary', 'Glioblastoma-obtained-Neoplasms', 'Idiopathic Pulmonary Fibrosis-result-Fibrosis', 'Idiopathic Pulmonary Fibrosis-result-Respiratory Insufficiency', 'Idiopathic Pulmonary Fibrosis-result-Death', 'Pneumonia-result-Fibrosis', 'Pneumonia-result-Respiratory Insufficiency', 'Fibrosis-result-Respiratory Insufficiency', 'Fibrosis-result-Death', 'Trigger Finger Disorder-cause-Gait Ataxia', 'Muscle Weakness-cause-Gait Ataxia', 'Esophageal Motility Disorders-characterized-Esophageal Neoplasms', 'Glioma-used-Neoplasms', 'Peripheral Arterial Disease-linked-Obesity', 'Muscle Weakness-appear-Death', 'Diverticulum, Colon-reduced-Colitis, Ulcerative', 'Colitis, Ulcerative-aged-Inflammatory Bowel Diseases', 'Sarcopenia-associated-Lung Neoplasms', 'Lung Neoplasms-associated-Sarcopenia', 'Hip Fractures-compare-Multiple Sclerosis', 'Peripheral Arterial Disease-accelerate-Arteriosclerosis', 'Diabetes Mellitus-show-Obesity', 'Obesity-observed-Prediabetic State', 'Brain Injuries, Traumatic-code-Death', 'Death-associated-Neurologic Manifestations', 'Neurologic Manifestations-associated-Death', 'Death-associated-Pathological Conditions, Anatomical', 'Pathological Conditions, Anatomical-associated-Death', 'Ataxia Telangiectasia-characterized-Cerebellar Ataxia', 'Ataxia Telangiectasia-characterized-Telangiectasis', 'Ataxia Telangiectasia-characterized-Immunologic Deficiency Syndromes', 'Chest Pain-recognised-Myocardial Infarction', 'Ataxia Telangiectasia-characterized-Neoplasms', 'Neoplasms-increase-Postoperative Cognitive Complications', 'Heredodegenerative Disorders, Nervous System-characterized-Cerebellar Ataxia', 'Heredodegenerative Disorders, Nervous System-characterized-Telangiectasis', 'Heredodegenerative Disorders, Nervous System-characterized-Immunologic Deficiency Syndromes', 'Heredodegenerative Disorders, Nervous System-characterized-Neoplasms', 'Metabolic Syndrome-refer-Metabolic Diseases', 'Vascular Calcification-related-Diabetes Mellitus', 'Osteoporosis-assess-Hearing Loss', 'Leukemia, Myeloid, Acute-occur-Neoplasms', 'Cockayne Syndrome-characterised-Growth Disorders', 'Hematologic Diseases-occur-Neoplasms', 'Cockayne Syndrome-characterised-Nervous System Diseases', 'Genetic Diseases, Inborn-characterised-Growth Disorders', 'Genetic Diseases, Inborn-characterised-Nervous System Diseases', 'Fever-worsen-Nervous System Diseases', 'Fever-worsen-Subarachnoid Hemorrhage', 'Nervous System Diseases-worsen-Subarachnoid Hemorrhage', 'Neoplasms-accelerate-Death', 'Multiple Chronic Conditions-accelerate-Death', 'Death-associate-Respiratory Tract Diseases', 'Respiratory Tract Diseases-associate-Death', 'Blood Loss, Surgical-provide-Neoplasms', 'Wounds and Injuries-result-Fractures, Bone', 'Obesity-associated-Genetic Diseases, Inborn', 'Genetic Diseases, Inborn-associated-Obesity', 'Fractures, Bone-contribute-Death', 'Wounds and Injuries-contribute-Death', 'Cardiac Output, Low-fall-Hip Fractures', 'Death-associated-Venous Thromboembolism', 'Venous Thromboembolism-associated-Death', 'Leukoencephalopathies-associated-Stroke', 'Stroke-associated-Leukoencephalopathies', 'Sepsis-identified-Malocclusion', 'Sepsis-identified-Infections', 'Stomatognathic Diseases-impose-Tooth Loss', 'Infections-associated-Peripheral Arterial Disease', 'Peripheral Arterial Disease-associated-Infections', 'Leukoencephalopathies-performed-Ischemia', 'Infections-associated-Atherosclerosis', 'Atherosclerosis-associated-Infections', 'Leukoencephalopathies-performed-Stroke', 'Sleep Wake Disorders-associated-Dementia', 'Dementia-associated-Sleep Wake Disorders', 'Sleep Wake Disorders-associated-Ossification of Posterior Longitudinal Ligament', 'Ossification of Posterior Longitudinal Ligament-associated-Sleep Wake Disorders', 'Psychoses, Substance-Induced-confined-Hallucinations', 'Leukoencephalopathies-associate-Ossification of Posterior Longitudinal Ligament', 'Ossification of Posterior Longitudinal Ligament-associate-Leukoencephalopathies', 'Osteoporosis-increase-Gait Disorders, Neurologic', 'Osteoporosis-follow-Osteoarthritis', 'Low Back Pain-increase-Gait Disorders, Neurologic', 'Gait Disorders, Neurologic-follow-Osteoarthritis', 'Gait Disorders, Neurologic-follow-Spinal Stenosis', 'Death-operated-Meningeal Neoplasms', 'Diabetes Mellitus-model-Death', 'Heart Diseases-model-Death', 'Dementia-model-Death', 'Diabetes Mellitus-include-Cachexia', 'Obesity-include-Cachexia', 'Sleep Apnea, Obstructive-associated-Death', 'Death-associated-Sleep Apnea, Obstructive', 'Renal Insufficiency-include-Cachexia', 'Osteoporosis-include-Cachexia', 'Asthma-Chronic Obstructive Pulmonary Disease Overlap Syndrome-associated-Death', 'Death-associated-Asthma-Chronic Obstructive Pulmonary Disease Overlap Syndrome', 'Craniocerebral Trauma-present-Wounds and Injuries', 'Craniocerebral Trauma-treat-Wounds and Injuries', 'Intestinal Diseases-associated-Venous Thrombosis', 'Venous Thrombosis-associated-Intestinal Diseases', 'Peri-Implantitis-cause-Death', 'Peri-Implantitis-cause-Neoplasms', 'Death-come-Cardiovascular Diseases', 'HIV Infections-associated-Neurodegenerative Diseases', 'Neurodegenerative Diseases-associated-HIV Infections', 'Thromboembolism-associated-Hemorrhage', 'Hemorrhage-associated-Thromboembolism', 'Malnutrition-related-Death', 'Malnutrition-influence-Death', 'Low Back Pain-ranked-Neck Pain', 'Low Back Pain-ranked-Coronary Artery Disease', 'Low Back Pain-ranked-Cerebrovascular Disorders', 'Low Back Pain-ranked-Respiratory Tract Infections', 'Low Back Pain-ranked-Back Pain', 'Neck Pain-ranked-Coronary Artery Disease', 'Neck Pain-ranked-Cerebrovascular Disorders', 'Neck Pain-ranked-Respiratory Tract Infections', 'Neck Pain-ranked-Back Pain', 'Back Pain-ranked-Coronary Artery Disease', 'Back Pain-ranked-Cerebrovascular Disorders', 'Intestinal Diseases-prevent-Thrombosis', 'Back Pain-ranked-Respiratory Tract Infections', 'Venous Thrombosis-prevent-Thrombosis', 'Neoplasms-associated-Breast Neoplasms', 'Breast Neoplasms-associated-Neoplasms', 'Hemorrhage-display-Acute Coronary Syndrome', 'Colorectal Neoplasms-suggest-Death', 'Dementia-suffer-Hallucinations', 'Atrial Fibrillation-associated-Cerebral Infarction', 'Cerebral Infarction-associated-Atrial Fibrillation', 'Dementia-suffer-Psychomotor Agitation', 'Sarcopenia-diagnosed-Obesity', 'Atrial Fibrillation-cause-Death', 'Renal Insufficiency, Chronic-associated-Cerebral Infarction', 'Cerebral Infarction-associated-Renal Insufficiency, Chronic', 'Renal Insufficiency, Chronic-associated-Hemorrhage', 'Hemorrhage-associated-Renal Insufficiency, Chronic', 'Renal Insufficiency, Chronic-cause-Death', 'Cerebral Infarction-cause-Death', 'Hemorrhage-cause-Death', 'Gastrointestinal Hemorrhage-cause-Death', 'Atrial Fibrillation-use-Renal Insufficiency, Chronic', 'Headache Disorders, Secondary-predispose-Breast Neoplasms', 'Headache Disorders, Secondary-predict-Breast Neoplasms', 'Osteoporotic Fractures-coupled-Osteoporosis', 'Osteoblastoma-considered-Bone Diseases', 'Neoplasms-considered-Bone Diseases', 'Communicable Diseases-associated-Death', 'Death-associated-Communicable Diseases', 'Communicable Diseases-reduce-Infections', 'Death-reduce-Infections', 'Pulmonary Disease, Chronic Obstructive-set-Death', 'Sarcopenia-suffer-Pulmonary Disease, Chronic Obstructive', 'Aneurysm-treated-Aneurysm, Ruptured', 'Facial Nerve Diseases-develop-Carpal Tunnel Syndrome', 'Malnutrition-found-Pulmonary Disease, Chronic Obstructive', 'Sarcopenia-found-Pulmonary Disease, Chronic Obstructive', 'Brain Diseases-associated-Obesity', 'Obesity-associated-Brain Diseases', 'Neoplasms-affected-Kidney Diseases', 'Hyperuricemia-associated-Renal Insufficiency, Chronic', 'Renal Insufficiency, Chronic-associated-Hyperuricemia', 'Sarcopenia-predict-Death', 'Lung Injury-characterized-Respiratory Distress Syndrome', 'Persistent Vegetative State-associated-Hydrocephalus', 'Hydrocephalus-associated-Persistent Vegetative State', 'Persistent Vegetative State-associated-Headache', 'Headache-associated-Persistent Vegetative State', 'Fractures, Bone-compare-Pain', 'Osteoarthritis-lead-Pain', 'Muscle Weakness-associated-Death', 'Death-associated-Muscle Weakness', 'Muscle Weakness-associated-Muscular Diseases', 'Muscular Diseases-associated-Muscle Weakness', 'Death-increase-Muscular Diseases', 'Neoplasms-queried-Glioblastoma', 'Neoplasms-diagnose-Glioblastoma', 'Calcinosis-increase-Peripheral Arterial Disease', 'Infections-cause-Pneumonia', 'Foot Ulcer-associate-Pain', 'Pain-associate-Foot Ulcer', 'Inflammatory Bowel Diseases-managed-Colitis, Ulcerative', 'Alzheimer Disease-define-Dementia', 'Atrophy-associated-Fractures, Bone', 'Fractures, Bone-associated-Atrophy', 'Alcoholism-related-Death', 'Delirium-underreport-Dementia', 'Pheochromocytoma-arise-Paraganglioma', 'Alzheimer Disease-resemble-Dementia', 'Alzheimer Disease-arise-Dementia', 'Fractures, Bone-occur-Macular Degeneration', 'Osteoporosis-evaluate-Fractures, Bone', 'Osteoporosis-developed-Fractures, Bone', 'Kidney Diseases-cause-Renal Insufficiency, Chronic', 'Dementia-develop-Hypertension', 'Stroke-investigate-Hypertension', 'Neoplasms-live-HIV Infections', 'Respiratory Tract Infections-associated-Myocardial Infarction', 'Myocardial Infarction-associated-Respiratory Tract Infections', 'Stroke-investigate-Dementia', 'Myoclonus-associated-Parkinson Disease, Secondary', 'Parkinson Disease, Secondary-associated-Myoclonus', 'Respiratory Tract Infections-associated-Stroke', 'Stroke-associated-Respiratory Tract Infections', 'Myoclonus-related-Dementia', 'Mouth Diseases-contribute-Pain', 'Osteoporosis-undergo-Neoplasm Invasiveness', 'Myoclonus-related-Mastocytosis, Systemic', 'Hematoma-performed-Intermittent Claudication', 'Chronic Disease-related-Metabolic Syndrome', 'Atrophy-used-Neurodegenerative Diseases', 'Atrophy-slow-Neurodegenerative Diseases', 'Hearing Loss-associated-Arthritis, Rheumatoid', 'Arthritis, Rheumatoid-associated-Hearing Loss', 'Multiple Trauma-extracted-Wounds and Injuries', 'Sarcopenia-associated-Cardiac Output, Low', 'Cardiac Output, Low-associated-Sarcopenia', 'Inflammation-linked-Alzheimer Disease', 'Hypertension-include-Cardiovascular Diseases', 'Sarcopenia-associated-Non-alcoholic Fatty Liver Disease', 'Non-alcoholic Fatty Liver Disease-associated-Sarcopenia', 'Fatty Liver-associated-Sarcopenia', 'Sarcopenia-associated-Fatty Liver', 'Carcinoma, Hepatocellular-recruit-Neoplasms', 'Fractures, Bone-related-Osteoporosis', 'Death-associated-Spinal Cord Injuries', 'Spinal Cord Injuries-associated-Death', 'Shock, Septic-associated-Death', 'Death-associated-Shock, Septic', 'Osteomyelitis-compare-Diabetes Mellitus', 'Osteomyelitis-compare-Osteoporosis', 'Arrhythmias, Cardiac-cause-Death', 'Osteomyelitis-diagnosed-Fractures, Bone', 'Osteoporosis-shown-Oculocerebrorenal Syndrome', 'Osteoporosis-shown-Death', 'Osteoporosis-shown-Heart Failure', 'Osteoporosis-shown-Fractures, Bone', 'Fractures, Bone-investigate-Osteomyelitis', 'Acquired Immunodeficiency Syndrome-account-Death', 'Acquired Immunodeficiency Syndrome-remain-Death', 'Cardiovascular Diseases-reported-Diabetes Mellitus', 'Tachycardia, Ventricular-associated-Heart Failure', 'Heart Failure-associated-Tachycardia, Ventricular', 'Status Epilepticus-reviewed-Death', 'Cerebral Amyloid Angiopathy-defined-Cerebral Hemorrhage', 'Cerebral Amyloid Angiopathy-associated-Cerebral Hemorrhage', 'Cerebral Hemorrhage-associated-Cerebral Amyloid Angiopathy', 'Neoplasms-obtain-Death', 'Kidney Neoplasms-extracted-Neoplasms', 'Parkinson Disease-characterised-Hypokinesia', 'Parkinson Disease-characterised-Tremor', 'Parkinson Disease-characterised-Muscle Rigidity', 'Movement Disorders-characterised-Hypokinesia', 'Movement Disorders-characterised-Tremor', 'Movement Disorders-characterised-Muscle Rigidity', 'Colorectal Neoplasms-register-Neoplasms', 'Neoplasms-associate-Death', 'Death-associate-Neoplasms', 'Immune System Diseases-known-Sinusitis', 'Immune System Diseases-known-Respiratory Tract Infections', 'Wounds and Injuries-associate-Hypothalamic Neoplasms', 'Hypothalamic Neoplasms-associate-Wounds and Injuries', 'Death-diagnosed-Sepsis', 'Death-diagnosed-Shock, Septic', 'Cerebrovascular Disorders-related-Delirium', 'Pulmonary Heart Disease-related-Delirium', 'Wounds and Injuries-associated-Fractures, Bone', 'Fractures, Bone-associated-Wounds and Injuries', 'Anemia-associated-Dementia', 'Dementia-associated-Anemia', 'Hypertension-find-Anemia', 'Diabetes Mellitus-find-Anemia', 'Osteosarcoma-termed-Osteoma', 'Osteosarcoma-termed-Bone Neoplasms', 'Osteoma-termed-Bone Neoplasms', 'Metabolic Diseases-associated-Obesity, Abdominal', 'Obesity, Abdominal-associated-Metabolic Diseases', 'Obesity, Abdominal-associated-Obesity', 'Obesity-associated-Obesity, Abdominal', 'Hematoma-observed-Coma', 'Death-arise-Hypertension', 'Death-arise-Obesity', 'Death-arise-Albuminuria', 'Hyperkalemia-tolerated-Renal Insufficiency, Chronic', 'Hematoma, Subdural, Acute-undergo-Hematoma', 'Hematoma, Subdural-undergo-Hematoma', 'Neoplasms-queried-Endometrial Neoplasms', 'Cardiovascular Diseases-tend-Infections', 'Cardiovascular Diseases-appear-Infections', 'Hyperkalemia-predisposed-Kidney Diseases', 'Pneumonia, Aspiration-reduce-Death', 'Atrial Fibrillation-associated-Alzheimer Disease', 'Alzheimer Disease-associated-Atrial Fibrillation', 'Dementia-exceed-Delirium', 'Non-alcoholic Fatty Liver Disease-associated-Fatty Liver', 'Fatty Liver-associated-Non-alcoholic Fatty Liver Disease', 'Non-alcoholic Fatty Liver Disease-point-Fatty Liver', 'Immunologic Deficiency Syndromes-associated-Dementia', 'Dementia-associated-Immunologic Deficiency Syndromes', 'Spinal Dysraphism-associated-Synovial Cyst', 'Synovial Cyst-associated-Spinal Dysraphism', 'Spinal Cord Injuries-used-Spinal Injuries', 'Spinal Fractures-used-Spinal Injuries', 'Heart Diseases-associated-Atrial Fibrillation', 'Atrial Fibrillation-associated-Heart Diseases', 'Atrial Fibrillation-found-Stroke', 'Heart Diseases-associated-Arrhythmias, Cardiac', 'Arrhythmias, Cardiac-associated-Heart Diseases', 'Neurodegenerative Diseases-lead-Dementia', 'Heart Diseases-include-Endocarditis', 'Neoplasms-undertreated-Death', 'Obesity-diagnosed-Arthritis', 'Hypertension-diagnosed-Arthritis', 'Neoplasms-contribute-Urologic Neoplasms', 'Cardiovascular Diseases-related-Hypertension', 'Cardiovascular Diseases-related-Dyslipidemias', 'Memory Disorders-under-reported-Hepatitis C', 'Inflammation-alter-Pulmonary Heart Disease', 'Hypertension-associated-Hypotension', 'Hypotension-associated-Hypertension', 'Dementia-associated-Hypotension', 'Hypotension-associated-Dementia', 'Inflammatory Bowel Diseases-correspond-Colitis, Ulcerative', 'Gastroenteritis-cause-Death', 'Idiopathic Pulmonary Fibrosis-diagnosed-Lung Neoplasms', 'Mental Fatigue-characterized-Fatigue', 'Lung Neoplasms-develop-Idiopathic Pulmonary Fibrosis', 'Lung Neoplasms-develop-Adenocarcinoma', 'Delirium-contribute-Death', 'Discitis-associated-Death', 'Death-associated-Discitis', 'Parkinson Disease-associated-Sleep Initiation and Maintenance Disorders', 'Sleep Initiation and Maintenance Disorders-associated-Parkinson Disease', 'Neoplasms-rising-Hematologic Neoplasms', 'Neoplasms-associated-Neurotoxicity Syndromes', 'Neurotoxicity Syndromes-associated-Neoplasms', 'Acromegaly-undergo-Pituitary Neoplasms', 'Pneumococcal Infections-prevent-Infections', 'Infections-control-Death', 'Osteoporosis-correlated-Cardiovascular Diseases', 'Osteoporosis-correlated-Hypertension', 'Osteoporosis-correlated-Coronary Artery Disease', 'Osteoporosis-correlated-Hyperlipidemias', 'Pneumococcal Infections-associated-Death', 'Death-associated-Pneumococcal Infections', 'Brain Injuries, Traumatic-admitted-Wounds and Injuries', 'Arthritis, Rheumatoid-compare-Hip Fractures', 'Dementia-provide-Neurodegenerative Diseases', 'Hyponatremia-associated-Death', 'Death-associated-Hyponatremia', 'Mitochondrial Diseases-play-Atherosclerosis', 'Death-extracted-Neoplasms', 'Colorectal Neoplasms-extracted-Neoplasms', 'Infections-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-Infections', 'Cardiovascular Diseases-defined-Coronary Artery Disease', 'Cardiovascular Diseases-combine-Coronary Artery Disease', 'Cardiovascular Diseases-defined-Myocardial Infarction', 'Cardiovascular Diseases-defined-Death', 'Cardiovascular Diseases-defined-Stroke', 'Coronary Artery Disease-defined-Myocardial Infarction', 'Coronary Artery Disease-defined-Death', 'Stroke-reduced-Hip Fractures', 'Coronary Artery Disease-defined-Stroke', 'Myocardial Infarction-defined-Death', 'Myocardial Infarction-defined-Stroke', 'Death-defined-Stroke', 'Seizures-regain-Prostatic Neoplasms', 'Death-increase-Cardiovascular Diseases', 'Chemical and Drug Induced Liver Injury-compare-HIV Infections', 'Cardiovascular Diseases-increased-Chemical and Drug Induced Liver Injury', 'Overbite-associated-Hypertension', 'Hypertension-associated-Overbite', 'Colorectal Neoplasms-increase-Obesity', 'Death-suggest-Diabetes Mellitus', 'Obesity-contribute-Colorectal Neoplasms', 'Atrial Fibrillation-share-Hypertension', 'Stroke-reduce-Hemorrhage', 'Sclerosis-characterized-Fibrosis', 'Dementia-certify-Death', 'Hepatic Insufficiency-result-Limb Deformities, Congenital', 'Hepatic Insufficiency-result-Ischemia', 'Muscular Atrophy-include-Metabolic Diseases', 'Diabetes Mellitus, Type 2-alter-Obesity', 'Diabetes Mellitus, Type 2-induce-Hypertension', 'Death-evaluated-Diabetes Mellitus, Type 2', 'Death-occur-HIV Infections', 'Death-classify-Immunologic Deficiency Syndromes', 'HIV Infections-classify-Death', 'HIV Infections-classify-Immunologic Deficiency Syndromes', 'Immunologic Deficiency Syndromes-apply-Death', 'Neoplasms-searched-Breast Neoplasms', 'Weight Loss-associated-Obesity', 'Obesity-associated-Weight Loss', 'Dementia-classified-Dementia, Vascular', 'Breast Neoplasms-identified-Neoplasms', 'Asthma-associated-Airway Obstruction', 'Airway Obstruction-associated-Asthma', 'Asthma-present-Inflammation', 'Neoplasms-result-Breast Neoplasms', 'Exanthema-complete-Breast Neoplasms', 'Exanthema-attribute-Neoplasms', 'Nervous System Diseases-rank-Death', 'Headache Disorders, Secondary-use-Peritoneal Neoplasms', 'Fractures, Bone-evaluated-Pain', 'Atrial Fibrillation-occur-Cerebral Infarction', 'Fractures, Bone-treat-Arthritis', 'Tauopathies-characterize-Plaque, Amyloid', 'Obesity-associated-Venous Thromboembolism', 'Venous Thromboembolism-associated-Obesity', 'Death-obtain-Neoplasms', 'Hyponatremia-identified-Hypopituitarism', 'Hyponatremia-treated-Hypopituitarism', 'Infections-show-Stomach Neoplasms', 'Gastritis, Atrophic-show-Stomach Neoplasms', 'Hyponatremia-recorded-Hypopituitarism', 'Neoplasms-assess-Malnutrition', 'Neoplasms-occur-Death', 'Colitis, Ulcerative-predispose-Infections', 'Agranulocytosis-remain-Sepsis', 'Agranulocytosis-remain-Infections', 'Agranulocytosis-remain-Pneumonia', 'Agranulocytosis-remain-Shock, Septic', 'Aneuploidy-characterized-Carcinoma, Squamous Cell', 'Anemia-demonstrated-Myelodysplastic Syndromes', 'Arthritis-suffer-Arthritis, Rheumatoid', 'Metabolic Syndrome-contribute-Cardiovascular Diseases', 'Obesity, Abdominal-contribute-Cardiovascular Diseases', 'Hyponatremia-associated-Osteoporosis', 'Osteoporosis-associated-Hyponatremia', 'Microvascular Angina-associated-Malaria', 'Malaria-associated-Microvascular Angina', 'Heart Failure-characterized-Hypotension', 'Heart Failure-characterized-Hypertrophy, Left Ventricular', 'Headache-assess-Brain Injuries', 'Arrhythmias, Cardiac-increase-Acute Coronary Syndrome', 'Psychoses, Substance-Induced-related-Alzheimer Disease', 'Arrhythmias, Cardiac-increase-Heart Arrest', 'Arrhythmias, Cardiac-increase-Heart Failure', 'Arrhythmias, Cardiac-increase-Pulmonary Edema', 'Acute Coronary Syndrome-increase-Heart Arrest', 'Alzheimer Disease-related-Psychoses, Substance-Induced', 'Alzheimer Disease-report-Psychoses, Substance-Induced', 'Stroke-reduce-Death', 'Anophthalmos-cause-Blindness', 'Thromboembolism-reduce-Death', 'Stroke-develop-Hemorrhage', 'Fractures, Bone-receive-Osteoporosis', 'Death-obtained-Neoplasms', 'Atrial Fibrillation-implicate-Cerebral Infarction', 'Hyperthyroidism-associated-Dementia', 'Dementia-associated-Hyperthyroidism', 'Stroke-identify-Atrial Fibrillation', 'Hip Fractures-under-treated-Osteoporosis', 'Carcinoma, Pancreatic Ductal-cause-Death', 'Ulcer-associate-Death', 'Death-associate-Ulcer', 'Atherosclerosis-associated-Coronary Artery Disease', 'Coronary Artery Disease-associated-Atherosclerosis', 'Neoplasms-show-Neoplasm Metastasis', 'Infections-remain-Death', 'Frailty-fall-Cardiac Output, Low', 'Death-defined-Albuminuria', 'Renal Insufficiency, Chronic-defined-Albuminuria', 'Pneumococcal Infections-followed-Infections', 'Glaucoma-raise-Blindness', 'Chronic Disease-associated-Arthritis', 'Arthritis-associated-Chronic Disease', 'Chronic Disease-cause-Pain', 'Arthritis-cause-Pain', 'Prostatic Neoplasms-associated-Death', 'Death-associated-Prostatic Neoplasms', 'Coronary Artery Disease-become-Death', 'Coronary Artery Disease-focus-Death', 'Purpura-characterized-Skin Diseases', 'Stomach Neoplasms-affect-Sarcopenia', 'HIV Infections-inform-Cardiovascular Diseases', 'Low Back Pain-evaluated-Pain', 'Stroke-assigned-Arthritis', 'Muscular Diseases-contribute-Obesity', 'Torsades de Pointes-associated-Death', 'Death-associated-Torsades de Pointes', 'Migraine Disorders-sustain-Chest Pain', 'Upper Extremity Deep Vein Thrombosis-undergo-Arteriovenous Fistula', 'Sensation Disorders-treat-Deglutition Disorders', 'Candidiasis-attributed-Dysbiosis', 'Arrhythmias, Cardiac-present-Heart Diseases', 'Mycoses-attributed-Dysbiosis', 'Hearing Loss, Central-hear-Language Development Disorders', 'Death-undergo-Fractures, Bone', 'Fractures, Bone-compare-Femoral Neck Fractures', 'Fractures, Bone-associated-Femoral Neck Fractures', 'Femoral Neck Fractures-associated-Fractures, Bone', 'Hypertension-increase-Death', 'Cardiovascular Diseases-increase-Death', 'Leukemia, Myeloid, Acute-diagnosed-Neoplasms', 'Retinal Diseases-protect-Retinitis', 'Osteoarthritis-associated-Death', 'Death-associated-Osteoarthritis', 'Sarcopenia-complicated-Heart Failure', 'Neurologic Manifestations-reported-HIV Infections', 'Ataxia-considered-Sarcopenia', 'Musculoskeletal Diseases-include-Rotator Cuff Injuries', 'Drug-Related Side Effects and Adverse Reactions-observed-Neoplasms', 'Drug-Related Side Effects and Adverse Reactions-show-Neoplasms', 'Neoplasms-introduce-Pain', 'Pain-include-Neoplasms', 'Angina Pectoris-include-Coronary Artery Disease', 'Angina, Unstable-include-Coronary Artery Disease', 'Myocardial Infarction-include-Coronary Artery Disease', 'Infections-induce-Chemical and Drug Induced Liver Injury', 'Diabetes Mellitus-include-Dystocia', 'Infections-accelerate-Liver Cirrhosis', 'Diabetes Mellitus-include-Abnormalities, Drug-Induced', 'Hepatitis C, Chronic-accelerate-Liver Cirrhosis', 'Diabetes Mellitus-include-Fractures, Bone', 'Diabetes Mellitus-include-Paralysis', 'Chemical and Drug Induced Liver Injury-accelerate-Liver Cirrhosis', 'Liver Cirrhosis-increase-Death', 'Death-quantify-Hip Fractures', 'Respiratory Tract Diseases-administered-Diabetes Mellitus', 'Dyspnea-reported-Cough', 'Sarcopenia-measured-Death', 'Diabetes Mellitus-reported-Cough', 'Pneumonia-caused-Infections', 'Respiratory Tract Diseases-caused-Infections', 'Inflammation-associated-Aortitis', 'Aortitis-associated-Inflammation', 'Renal Insufficiency, Chronic-complicate-Hypertension', 'Renal Insufficiency, Chronic-complicate-Diabetes Mellitus', 'Cardiovascular Diseases-associated-Hearing Loss', 'Hearing Loss-associated-Cardiovascular Diseases', 'Sarcopenia-lead-Obesity', 'Malaria-related-Death', 'Malaria-contribute-Death', 'Death-used-Sepsis', 'Death-represent-Sepsis', 'Epilepsy, Temporal Lobe-associated-Brain Damage, Chronic', 'Brain Damage, Chronic-associated-Epilepsy, Temporal Lobe', 'Sepsis-related-Death', 'Sepsis-reveal-Death', 'Sepsis-reveal-Chronic Disease', 'Peptic Ulcer-associated-Death', 'Death-associated-Peptic Ulcer', 'Diabetes Mellitus-become-Death', 'Dementia-related-Neurodegenerative Diseases', 'Atherosclerosis-associated-Intracranial Arteriosclerosis', 'Intracranial Arteriosclerosis-associated-Atherosclerosis', 'Atherosclerosis-associated-Stroke', 'Stroke-associated-Atherosclerosis', 'Dementia-lead-Neurodegenerative Diseases', 'Arthritis, Rheumatoid-undergo-Spinal Diseases', 'Death-present-Acute Coronary Syndrome', 'Dementia-related-Leukoencephalopathies', 'Death-understand-HIV Infections', 'Retinal Artery Occlusion-include-Carotid Stenosis', 'Retinal Artery Occlusion-include-Diabetes Mellitus', 'Retinal Artery Occlusion-include-Hyperlipidemias', 'Retinal Artery Occlusion-include-Stroke', 'Abdominal Pain-cause-Obesity', 'Pneumonia-associated-Sepsis', 'Sepsis-associated-Pneumonia', 'Death-increase-Hyperkalemia', 'Heart Failure-increase-Hyperkalemia', 'Low Back Pain-associated-Retinal Degeneration', 'Retinal Degeneration-associated-Low Back Pain', 'Hypertension-associated-Hypotension, Orthostatic', 'Hypotension, Orthostatic-associated-Hypertension', 'Obesity-associated-Glucose Metabolism Disorders', 'Glucose Metabolism Disorders-associated-Obesity', 'Pain-lead-Fractures, Bone', 'Ischemia-associated-Death', 'Death-associated-Ischemia', 'Pulmonary Disease, Chronic Obstructive-found-Prostatic Hyperplasia', 'Diabetes Mellitus-linked-Dementia', 'Dementia-remain-Diabetes Mellitus', 'Diabetes Mellitus-associated-Prediabetic State', 'Prediabetic State-associated-Diabetes Mellitus', 'Carotid Artery Diseases-associated-Alzheimer Disease', 'Alzheimer Disease-associated-Carotid Artery Diseases', 'Atrial Fibrillation-increase-Thromboembolism', 'Death-reduce-Hemorrhage', 'Arrhythmias, Cardiac-increase-Thromboembolism', 'Huntington Disease-involve-Testicular Diseases', 'Neurodegenerative Diseases-involve-Testicular Diseases', 'Cystadenocarcinoma, Serous-characterized-Neoplasms', 'Cerebrovascular Disorders-develop-Stroke', 'Nervous System Diseases-longstand-Pain', 'Diabetes Mellitus-shown-Obesity', 'Diabetes Mellitus-shown-Hypertension', 'Fasciitis, Necrotizing-defined-Infections', 'Fasciitis, Necrotizing-defined-Necrosis', 'Metabolic Syndrome-related-Obesity', 'Metabolic Syndrome-increase-Obesity', 'Chronic Pain-reflect-Pain', 'Papillomavirus Infections-underlie-Neoplasms', 'Papillomavirus Infections-underlie-Precancerous Conditions', 'Tibial Neuropathy-used-Pain', 'Atrial Fibrillation-prevent-Thromboembolism', 'Thromboembolism-prevent-Hemorrhage', 'Delirium-detect-Dementia', 'Candidiasis-treat-Mycoses', 'Obesity-predict-Metabolic Syndrome', 'Alzheimer Disease-assess-Brain Diseases', 'Mitochondrial Diseases-associated-Sarcopenia', 'Sarcopenia-associated-Mitochondrial Diseases', 'Frailty-exert-Hypertension', 'Hearing Loss-decrease-Vision Disorders', 'Sarcopenia-assess-Inflammation', 'Sarcopenia-use-Inflammation', 'Cardiovascular Diseases-diagnose-Sarcopenia', 'Vision Disorders-associated-Sensation Disorders', 'Sensation Disorders-associated-Vision Disorders', 'Auditory Perceptual Disorders-contribute-Communication Disorders', 'Cataract-reflect-Death', 'Obesity-needed-Ossification of Posterior Longitudinal Ligament', 'Neoplasm Metastasis-include-Breast Neoplasms', 'Muscular Atrophy-associated-Inflammation', 'Inflammation-associated-Muscular Atrophy', 'Olfaction Disorders-reported-Ageusia', 'Mastocytosis, Systemic-characterized-Metabolic Diseases', 'Diabetes Mellitus, Type 2-develop-HIV Infections', 'Pneumonia-remain-Infections', 'Carcinoma, Non-Small-Cell Lung-undergo-Lymphoma, Large-Cell, Anaplastic', 'Carcinoma, Non-Small-Cell Lung-undergo-Adenocarcinoma of Lung', 'Hypertension-stratify-Cardiovascular Diseases', 'Hypertension-stratify-Diabetes Mellitus', 'Diabetes Mellitus, Type 2-include-Metabolic Syndrome', 'Death-predict-Kidney Failure, Chronic', 'Cardiovascular Diseases-stand-Angina Pectoris', 'Diabetes Mellitus-coexist-Diabetes Mellitus, Type 2', 'Hypertension-coexist-Diabetes Mellitus, Type 2', 'Dementia-evaluate-Memory Disorders', 'Atrial Fibrillation-use-Cerebral Infarction', 'Delirium-associated-Dementia', 'Dementia-associated-Delirium', 'Myalgia-involved-Heart Arrest', 'Exanthema-complicated-Pain', 'Exanthema-complicated-Neuralgia', 'Sarcoma, Clear Cell-followed-Fractures, Bone', 'Neoplasms-identify-Kidney Neoplasms', 'Neoplasms-account-Adenoma', 'Pulmonary Disease, Chronic Obstructive-associated-Muscular Atrophy', 'Muscular Atrophy-associated-Pulmonary Disease, Chronic Obstructive', 'Pain-report-Alzheimer Disease', 'Diabetic Foot-associated-Death', 'Death-associated-Diabetic Foot', 'Atrophy-suffer-Alzheimer Disease', 'Fatigue-faced-Neoplasms', 'Pain-faced-Neoplasms', 'Dementia-diagnose-Psychoses, Substance-Induced', 'Hypotension-associated-Atrioventricular Block', 'Atrioventricular Block-associated-Hypotension', 'Spondylosis-observed-Spinal Cord Diseases', 'Wounds and Injuries-diagnose-Hemorrhage', 'Inflammation-associated-Multiple Organ Failure', 'Multiple Organ Failure-associated-Inflammation', 'Wounds and Injuries-used-Rupture', 'Wounds and Injuries-classify-Rupture', 'Hemorrhage-diagnose-Craniocerebral Trauma', 'Wounds and Injuries-used-Anophthalmos', 'Wounds and Injuries-classify-Anophthalmos', 'Wounds and Injuries-used-Ocular Hypertension', 'Death-experience-Spondylosis', 'Hypokinesia-exist-Parkinson Disease', 'Sarcopenia-identified-Neoplasms', 'Acute Kidney Injury-undergo-Hip Fractures', 'Atherosclerosis-cause-Myocardial Infarction', 'Atherosclerosis-cause-Heart Failure', 'Atherosclerosis-cause-Stroke', 'Dementia-confound-Sleep Wake Disorders', 'Seizures-confound-Sleep Wake Disorders', 'Kyphosis-related-Death', 'Cardiovascular Diseases-cause-Myocardial Infarction', 'Cardiovascular Diseases-cause-Heart Failure', 'Sleep Wake Disorders-confound-Seizures', 'Cardiovascular Diseases-cause-Stroke', 'Alzheimer Disease-characterized-Atrophy', 'Temporomandibular Joint Disorders-associated-Arthritis, Rheumatoid', 'Arthritis, Rheumatoid-associated-Temporomandibular Joint Disorders', 'Arthritis, Rheumatoid-reduce-Glaucoma, Open-Angle', 'Temporomandibular Joint Disorders-reduce-Glaucoma, Open-Angle', 'Death-obtained-Fibrosis', 'Ascites-diagnose-Sarcopenia', 'Ascites-predict-Death', 'Carcinoma, Ovarian Epithelial-analyzed-Neoplasms, Cystic, Mucinous, and Serous', 'Heart Failure-become-HIV Infections', 'Hypoxia, Brain-described-Heart Arrest', 'Kidney Diseases-avoid-Hypertension', 'Kidney Diseases-avoid-Diabetes Mellitus', 'Heart Failure-run-Dementia', 'Obesity-outline-Death', 'Diabetes Mellitus-outline-Death', 'Obesity-prevent-Osteoporosis', 'Somatosensory Disorders-play-Shoulder Impingement Syndrome', 'Cardiomyopathy, Dilated-benefit-Peri-Implantitis', 'Death-benefit-Peri-Implantitis', 'Dementia-superimposed-Delirium', 'Cardiovascular Diseases-manifested-Aneurysm', 'Cardiovascular Diseases-manifested-Heart Failure', 'Death-mention-Hepatitis C', 'Cardiovascular Diseases-manifested-Stroke', 'Cardiovascular Diseases-manifested-Peripheral Arterial Disease', 'Death-associated-Hepatitis B', 'Hepatitis B-associated-Death', 'Inflammation-associate-Cardiovascular Diseases', 'Cardiovascular Diseases-associate-Inflammation', 'Parkinsonian Disorders-associate-Parkinson Disease', 'Parkinson Disease-associate-Parkinsonian Disorders', 'Mucopolysaccharidosis III-associate-Parkinson Disease', 'Parkinson Disease-associate-Mucopolysaccharidosis III', 'Hypertrophy-considered-Spinal Stenosis', 'Hypotension-recognised-Syncope', 'Death-affect-Hip Fractures', 'Hypotension-recognised-Death', 'Death-calculated-Neoplasms', 'Dementia-resemble-Death', 'Death-calculated-Cardiovascular Diseases', 'Dementia-compare-Death', 'Fractures, Open-related-Sexual Dysfunction, Physiological', 'Death-calculated-Wounds and Injuries', 'Delirium-undergo-Head and Neck Neoplasms', 'Anemia-linked-Sleep Initiation and Maintenance Disorders', 'Anemia, Iron-Deficiency-experience-Sleep Initiation and Maintenance Disorders', 'Muscle Weakness-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-Muscle Weakness', 'Fractures, Bone-collected-Death', 'Fractures, Bone-spent-Death', 'Ventricular Remodeling-observed-Hypertension', 'Ventricular Remodeling-observed-Heart Failure', 'Spinal Cord Injuries-achieve-Seizures', 'Cerebellar Diseases-contribute-Alzheimer Disease', 'Cachexia-found-Neoplasms', 'Neoplasms-found-Muscular Atrophy', 'Unconsciousness-predict-Death', 'Unconsciousness-predict-Aortic Aneurysm', 'Ischemia-predict-Death', 'Ischemia-predict-Aortic Aneurysm', 'Leukoencephalopathies-associated-Dementia', 'Dementia-associated-Leukoencephalopathies', 'Death-predict-Aortic Aneurysm', 'Cataract-enhance-Skin Neoplasms', 'Hyperalgesia-affected-Pain', 'Hyperalgesia-found-Osteoarthritis', 'Sleep Wake Disorders-relate-Dementia', 'Neoplasms-associated-Heart Failure, Systolic', 'Heart Failure, Systolic-associated-Neoplasms', 'Neoplasms-associated-Myocardial Infarction', 'Myocardial Infarction-associated-Neoplasms', 'Neoplasms-associated-Atrial Fibrillation', 'Atrial Fibrillation-associated-Neoplasms', 'Heart Failure, Systolic-associated-Myocardial Infarction', 'Myocardial Infarction-associated-Heart Failure, Systolic', 'Atrial Fibrillation-associated-Myocardial Infarction', 'Myocardial Infarction-associated-Atrial Fibrillation', 'Stroke-increase-Infections', 'Infections-examine-Stroke', 'Appendicitis-provide-Inflammation', 'Takotsubo Cardiomyopathy-differentiate-Acute Coronary Syndrome', 'Pulmonary Disease, Chronic Obstructive-demonstrate-Neurologic Manifestations', 'Neurologic Manifestations-reported-Dementia', 'Hypertension-increase-Diabetes Mellitus', 'Hypertension-increase-Heart Diseases', 'Hypertension-influenced-Stroke', 'Diabetes Mellitus-play-Atherosclerosis', 'Sarcopenia-associated-Dyspnea', 'Dyspnea-associated-Sarcopenia', 'Diabetes Mellitus-affect-Cardiovascular Diseases', 'Diabetes Mellitus-affect-Death', 'Diabetes Mellitus-affect-Heart Failure', 'Neoplasms-undergo-Adenocarcinoma', 'Sleep Wake Disorders-associated-Rhinitis, Allergic', 'Rhinitis, Allergic-associated-Sleep Wake Disorders', 'Osteoporosis-diagnosed-Sarcopenia', 'Breast Neoplasms-ascertained-Neoplasms', 'Memory Disorders-studied-Dementia', 'Cerebral Hemorrhage-carry-Stroke', 'Cerebral Hemorrhage-carry-Death', 'Atrial Fibrillation-carry-Stroke', 'Coronary Artery Disease-increase-Death', 'Cerebral Hemorrhage-become-Atrial Fibrillation', 'Cerebral Small Vessel Diseases-contribute-Dementia', 'Neurodegenerative Diseases-progress-Dementia', 'Dyspnea, Paroxysmal-associated-Heart Failure', 'Heart Failure-associated-Dyspnea, Paroxysmal', 'Aneurysm-become-Aortic Aneurysm', 'Peripheral Nervous System Diseases-affect-Breast Neoplasms', 'Pain-associated-Death', 'Death-associated-Pain', 'Sleep Wake Disorders-associated-Heart Failure', 'Heart Failure-associated-Sleep Wake Disorders', 'Melanoma-present-Neoplasms', 'Hypertension-include-Dementia', 'Hypertension-include-Aneurysm', 'Hip Fractures-collected-Neoplasms', 'Hip Fractures-collected-Respiratory Tract Diseases', 'Hip Fractures-report-Respiratory Tract Diseases', 'Muscular Disorders, Atrophic-compare-Osteoarthritis', 'Microaneurysm-considered-Aneurysm', 'Atrial Fibrillation-associated-Obesity', 'Obesity-associated-Atrial Fibrillation', 'Femoral Neck Fractures-associated-Osteonecrosis', 'Osteonecrosis-associated-Femoral Neck Fractures', 'Hypoxia-include-Delirium', 'Mitochondrial Diseases-include-Delirium', 'Parkinson Disease-diagnosed-Dementia', 'Immunologic Deficiency Syndromes-linked-Death', 'Immunologic Deficiency Syndromes-linked-Neoplasms', 'Pulmonary Disease, Chronic Obstructive-related-Bronchitis', 'Neoplasms-comprise-Colorectal Neoplasms', 'Albuminuria-suggested-Hypertension', 'Albuminuria-suggested-Diabetes Mellitus', 'Atherosclerosis-predict-Death', 'Atherosclerosis-predict-Dementia', 'Chorioretinitis-result-Ocular Hypertension', 'Chorioretinitis-associated-Sarcoidosis', 'Sarcoidosis-associated-Chorioretinitis', 'Postoperative Hemorrhage-undergo-Hematoma, Subdural, Chronic', 'Mitochondrial Diseases-lead-Hearing Loss', 'Pleural Effusion-cause-Death', 'Diabetes Mellitus-associated-Glomerulonephritis', 'Glomerulonephritis-associated-Diabetes Mellitus', 'Kidney Diseases-associated-Hypertension', 'Hypertension-associated-Kidney Diseases', 'Kidney Diseases-associated-Glomerulonephritis', 'Glomerulonephritis-associated-Kidney Diseases', 'Hypertension-associated-Glomerulonephritis', 'Glomerulonephritis-associated-Hypertension', 'Hip Fractures-fall-Cardiac Output, Low', 'Parkinson Disease-represent-Neurodegenerative Diseases', 'Kidney Diseases-superimposed-Diabetic Nephropathies', 'Cardiac Output, Low-occur-Hip Fractures', 'Myocardial Infarction-classified-Diabetes Mellitus', 'Parkinson Disease-go-Retinal Degeneration', 'Vascular Calcification-associated-Death', 'Death-associated-Vascular Calcification', 'Vascular Calcification-associated-Myocardial Infarction', 'Myocardial Infarction-associated-Vascular Calcification', 'Stomach Neoplasms-considered-Communicable Diseases', 'Delirium-observed-Dementia', 'Diabetes Mellitus-associated-Hypoglycemia', 'Hypoglycemia-associated-Diabetes Mellitus', 'Atherosclerosis-associated-Urinary Bladder, Overactive', 'Urinary Bladder, Overactive-associated-Atherosclerosis', 'Cardiac Output, Low-fall-Pain', 'Cardiac Output, Low-fall-Diabetes Mellitus', 'Cardiac Output, Low-differ-Diabetes Mellitus', 'Hip Fractures-cause-Death', 'Arthritis-associated-Cardiac Output, Low', 'Cardiac Output, Low-associated-Arthritis', 'Arthritis-fall-Cardiac Output, Low', 'Rheumatic Diseases-associated-Cardiac Output, Low', 'Cardiac Output, Low-associated-Rheumatic Diseases', 'Rheumatic Diseases-fall-Cardiac Output, Low', 'Weight Gain-contribute-Obesity', 'Delirium-assess-Hip Fractures', 'Hip Fractures-treat-Delirium', 'Ankle Fractures-treated-Wounds and Injuries', 'Infections-known-Diarrhea', 'Clostridium Infections-known-Diarrhea', 'Hip Fractures-define-Acute Kidney Injury', 'Anophthalmos-prevent-Vision Disorders', 'Neoplasms-found-Carcinoma, Squamous Cell', 'Stroke-present-Deglutition Disorders', 'Osteoporotic Fractures-treat-Back Pain', 'Osteoporotic Fractures-alleviate-Back Pain', 'Osteoporotic Fractures-correct-Musculoskeletal Diseases', 'Back Pain-correct-Musculoskeletal Diseases', 'Fractures, Bone-treat-Back Pain', 'Fractures, Bone-alleviate-Back Pain', 'Fractures, Bone-correct-Musculoskeletal Diseases', 'Hepatitis E-occur-Infections', 'Hip Fractures-induce-Lung Injury', 'Coronary Artery Disease-coexist-Heart Defects, Congenital', 'Hip Fractures-induce-Respiratory Tract Infections', 'Hip Fractures-induce-Death', 'Colitis-associated-Infections', 'Infections-associated-Colitis', 'Dry Eye Syndromes-characterized-Vision Disorders', 'Disease-characterized-Vision Disorders', 'Osteoporosis-associated-Pain', 'Pain-associated-Osteoporosis', 'Death-described-Fractures, Bone', 'Carcinoma, Hepatocellular-remain-Neoplasms', 'Fibrosis-remain-Neoplasms', 'Memory Disorders-classify-Dementia', 'Pelvic Floor Disorders-include-Urinary Incontinence, Stress', 'Pelvic Floor Disorders-include-Fecal Incontinence', 'Neoplasms-report-Death', 'Alzheimer Disease-compare-Neoplasms', 'Dementia-compare-Neoplasms', 'Death-compare-Neoplasms', 'Osteoporosis-characterized-Bone Neoplasms', 'Hallucinations-reported-Epilepsy', 'Neoplasms-reduce-Alzheimer Disease', 'Joint Diseases-obtained-Alkaptonuria', 'Alkaptonuria-obtained-Wounds and Injuries', 'Metabolism, Inborn Errors-result-Genetic Diseases, Inborn', 'Sarcopenia-correlated-Bone Diseases, Metabolic', 'Sarcopenia-correlated-Pulmonary Disease, Chronic Obstructive', 'Osteoporosis-fail-Fractures, Bone', 'Osteoporosis-recognize-Fractures, Bone', 'Niemann-Pick Disease, Type A-studied-Pneumonia', 'Hypotension, Orthostatic-observed-Parkinson Disease', 'Malocclusion-select-Spondylosis', 'Death-assess-Hypertension', 'Colitis, Ulcerative-exhibit-Death', 'Crohn Disease-exhibit-Death', 'Stroke-decrease-Death', 'Weight Loss-develop-Dementia', 'Death-favor-Tuberculosis', 'Hypertension-affect-Frailty', 'Hip Fractures-change-Death', 'Hip Fractures-improve-Death', 'Stroke-associated-Neurodegenerative Diseases', 'Neurodegenerative Diseases-associated-Stroke', 'Stroke-associated-Cerebral Infarction', 'Cerebral Infarction-associated-Stroke', 'Inflammation-known-Peripheral Arterial Disease', 'Atherosclerosis-known-Peripheral Arterial Disease', 'Death-explore-Coronary Artery Disease', 'Headache Disorders, Secondary-follow-Wounds and Injuries', 'Alzheimer Disease-documented-Adrenal Insufficiency', 'Headache Disorders, Secondary-referred-Wounds and Injuries', 'Urinary Incontinence-associated-Parkinson Disease, Secondary', 'Parkinson Disease, Secondary-associated-Urinary Incontinence', 'Stroke-registered-Cerebral Infarction', 'Obesity-include-Metabolic Diseases', 'Lipid Metabolism Disorders-include-Metabolic Diseases', 'Urinary Incontinence-accumulate-Parkinson Disease', 'Parkinson Disease, Secondary-accumulate-Parkinson Disease', 'Death-hospitalised-Hip Fractures', 'Neoplasms-use-Lung Neoplasms', 'Death-use-Neoplasms', 'Hip Fractures-identify-Death', 'Hip Fractures-describe-Death', 'Acute Coronary Syndrome-compare-Angina Pectoris', 'HIV Infections-associated-Lung Neoplasms', 'Lung Neoplasms-associated-HIV Infections', 'Spinal Fractures-admitted-Wounds and Injuries', 'Death-occur-Renal Insufficiency, Chronic', 'Hip Fractures-malnourished-Fractures, Bone', 'Seizures-associated-Neoplasms', 'Neoplasms-associated-Seizures', 'Skin Diseases-evidence-Erythema', 'Brain Injuries, Traumatic-relate-Death', 'Chronic Disease-related-Malnutrition', 'Chronic Disease-related-Anemia', 'Chronic Disease-related-Stroke', 'Chronic Disease-related-Peptic Ulcer', 'Hypotension-defined-Hypertension', 'Atherosclerosis-associate-Coronary Artery Disease', 'Coronary Artery Disease-associate-Atherosclerosis', 'Heart Failure-classified-Atherosclerosis', 'Anemia-increase-Death', 'Hypogonadism-identified-Ataxia Telangiectasia', 'Spinal Cord Injuries-identified-Ataxia Telangiectasia', 'Spinal Cord Injuries-performed-Hypogonadism', 'Hypertension-include-Hypotension, Orthostatic', 'Spinal Cord Injuries-trigger-Hypogonadism', 'Death-offset-Heart Diseases', 'Death-decline-Heart Diseases', 'Death-offset-Neoplasms', 'Death-decline-Neoplasms', 'Intracranial Aneurysm-carry-Rupture', 'Fractures, Bone-reduce-Postpartum Hemorrhage', 'Vestibulocochlear Nerve Diseases-associated-Atrophy', 'Atrophy-associated-Vestibulocochlear Nerve Diseases', 'Epilepsy-suspect-Seizures', 'Hip Fractures-undergo-Atrial Fibrillation', 'Heart Failure, Diastolic-related-Heart Failure', 'Neoplasms-caused-Peritoneal Neoplasms', 'Bone Marrow Diseases-associated-Neutropenia', 'Neutropenia-associated-Bone Marrow Diseases', 'Paraproteinemias-range-Multiple Myeloma', 'Muscular Atrophy-known-Sarcopenia', 'Muscular Atrophy-identified-Heart Failure', 'Atrial Fibrillation-improve-Heart Failure', 'Anemia-associated-Obesity', 'Obesity-associated-Anemia', 'Soft Tissue Injuries-stabilized-Fractures, Bone', 'Heart Failure-associated-Sarcopenia', 'Sarcopenia-associated-Heart Failure', 'Epilepsy-reported-Drug Resistant Epilepsy', 'Gastrointestinal Hemorrhage-recognized-Colonic Neoplasms', 'Malnutrition-associated-Hip Fractures', 'Hip Fractures-associated-Malnutrition', 'Aneurysm-characterized-Constriction, Pathologic', 'Osteoporosis-affect-Hip Fractures', 'Obesity-explain-Diabetes Mellitus, Type 2', 'Dementia-include-Delirium', 'Prostatic Neoplasms-treat-Drug-Related Side Effects and Adverse Reactions', 'Neoplasms-select-Colorectal Neoplasms', 'Meibomian Gland Dysfunction-involve-Chronic Disease', 'Stroke-used-Cerebral Hemorrhage', 'Stroke-assess-Cerebral Hemorrhage', 'Sleep Initiation and Maintenance Disorders-help-Disorders of Excessive Somnolence', 'Cardiovascular Diseases-investigate-Cerebrovascular Disorders', 'Infections-reduce-Inflammation', 'Inflammation-reduce-Pneumococcal Infections', 'Inflammation-reduce-Infections', 'Atrophy-reported-Alzheimer Disease', 'Cardiovascular Diseases-account-Death', 'Leukoencephalopathies-include-Aneurysm', 'Stroke, Lacunar-include-Aneurysm', 'Cardiovascular Diseases-become-Heart Failure', 'Nociceptive Pain-reported-Muscle Spasticity', 'Neuralgia-reported-Muscle Spasticity', 'Breast Neoplasms-participate-Weight Loss', 'Colorectal Neoplasms-occupy-Neoplasms', 'Halitosis-associated-Xerostomia', 'Xerostomia-associated-Halitosis', 'Halitosis-occur-Xerostomia', 'Halitosis-associated-Periodontal Diseases', 'Periodontal Diseases-associated-Halitosis', 'Halitosis-occur-Periodontal Diseases', 'Halitosis-associated-Calculi', 'Calculi-associated-Halitosis', 'Halitosis-occur-Calculi', 'Halitosis-associated-Dementia', 'Dementia-associated-Halitosis', 'Halitosis-found-Dementia', 'Chronic Disease-affected-Death', 'Neoplasms-reduce-Death', 'Colorectal Neoplasms-undergo-Neoplasms', 'Skin Neoplasms-include-Carcinoma, Basal Cell', 'Carcinoma, Basal Cell-extracted-Neoplasms', 'Skin Neoplasms-include-Carcinoma, Squamous Cell', 'Carcinoma, Squamous Cell-extracted-Neoplasms', 'Skin Neoplasms-extracted-Neoplasms', 'Hypotension-predict-Diabetes Mellitus', 'Hypotension-predict-Cardiovascular Diseases', 'Hypotension-predict-Dementia', 'Metabolic Diseases-related-Chronic Disease', 'Renal Insufficiency, Chronic-associated-Dyslipidemias', 'Dyslipidemias-associated-Renal Insufficiency, Chronic', 'Lip Diseases-include-Seizures', 'Mitochondrial Diseases-accompanied-Inflammation', 'Renal Insufficiency, Chronic-associated-Obesity', 'Obesity-associated-Renal Insufficiency, Chronic', 'Lip Diseases-associated-Seizures', 'Seizures-associated-Lip Diseases', 'Neoplasms-include-HIV Infections', 'Neoplasms-occur-HIV Infections', 'Death-understudied-Venous Thromboembolism', 'Ulcer-Perforated-Death', 'Ulcer-associated-Death', 'Death-associated-Ulcer', 'Fatigue-found-Hypogonadism', 'Inflammation-get-Respiratory Distress Syndrome', 'Parkinsonian Disorders-associated-Neurodegenerative Diseases', 'Neurodegenerative Diseases-associated-Parkinsonian Disorders', 'Fibrosis-treated-Hepatitis B', 'Fibrosis-related-Hepatitis B, Chronic', 'Atrial Fibrillation-observed-Heart Defects, Congenital', 'Coronary Artery Disease-follow-Death', 'Dyspnea-determine-Hypoxia', 'Inflammation-associated-Arthritis', 'Arthritis-associated-Inflammation', 'Tooth Loss-linked-Chronic Disease', 'Choledocholithiasis-represent-Gallstones', 'Diabetes Mellitus-followed-Death', 'Neoplasms-followed-Urinary Bladder Neoplasms', 'Prostatic Neoplasms-followed-Urinary Bladder Neoplasms', 'Prostatic Neoplasms-diagnosed-Neoplasms', 'Prostatic Neoplasms-followed-Neoplasms', 'Death-predict-Fibrosis', 'Pain-related-Osteoarthritis', 'Pick Disease of the Brain-include-Cerebral Amyloid Angiopathy', 'Pick Disease of the Brain-compared-Cerebral Amyloid Angiopathy', 'Hypertension-target-Respiratory Tract Diseases', 'Heart Failure-target-Respiratory Tract Diseases', 'Hepatitis B-examine-Cholangiocarcinoma', 'Hypesthesia-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-Hypesthesia', 'Joint Diseases-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-Joint Diseases', 'Acanthosis Nigricans-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-Acanthosis Nigricans', 'Neurodegenerative Diseases-underlie-Alzheimer Disease', 'Intermittent Claudication-caused-Peripheral Arterial Disease', 'Diabetes Mellitus, Type 2-increase-Alzheimer Disease', 'Hypernatremia-associated-Death', 'Death-associated-Hypernatremia', 'Osteoporosis-expose-Fractures, Bone', 'Leukoencephalopathies-observed-Migraine Disorders', 'Arthritis, Rheumatoid-associated-Death', 'Death-associated-Arthritis, Rheumatoid', 'Dementia-suggest-Neurodegenerative Diseases', 'Death-considered-Hip Fractures', 'Neurodegenerative Diseases-associated-Movement Disorders', 'Movement Disorders-associated-Neurodegenerative Diseases', 'Pneumonia-induce-Death', 'Angiodysplasia-increase-Hemorrhage', 'Heart Diseases-increase-Hemorrhage', 'Heart Diseases-stay-Death', 'Pneumonia-remain-Streptococcal Infections', 'Asthma-compare-Inflammation', 'Oculocerebrorenal Syndrome-enrolled-Diabetes Mellitus', 'Pneumonia-identified-Meningitis, Bacterial', 'Pneumonia-identified-Meningitis', 'Pneumonia-associated-Meningitis', 'Meningitis-associated-Pneumonia', 'Pneumonia-identified-Sepsis', 'Pneumonia-identified-Empyema', 'Pneumonia-associated-Empyema', 'Empyema-associated-Pneumonia', 'Meningitis-associated-Meningitis, Bacterial', 'Meningitis, Bacterial-associated-Meningitis', 'Sepsis-associated-Meningitis, Bacterial', 'Meningitis, Bacterial-associated-Sepsis', 'Empyema-associated-Meningitis, Bacterial', 'Meningitis, Bacterial-associated-Empyema', 'Critical Illness-suffering-Dementia', 'Subarachnoid Hemorrhage-harbor-Aneurysm', 'Death-explain-Weight Loss', 'Hematoma, Subdural, Chronic-make-Liver Diseases', 'Osteoporosis-cause-Fractures, Bone', 'HIV Infections-cause-Kidney Diseases', 'Pancreatitis, Chronic-associated-Death', 'Death-associated-Pancreatitis, Chronic', 'Alzheimer Disease-characterized-Nerve Degeneration', 'Pancreatic Neoplasms-associated-Death', 'Death-associated-Pancreatic Neoplasms', 'Alzheimer Disease-defined-Neurodegenerative Diseases', 'Death-related-Appendicitis', 'Diabetes Mellitus-compare-Death', 'Fallopian Tube Diseases-receive-Neoplasms', 'Cardiovascular Diseases-receive-Myocardial Infarction', 'Cardiovascular Diseases-comprise-Angina Pectoris', 'Hip Fractures-reduce-Pain', 'Cardiovascular Diseases-comprise-Cerebral Infarction', 'Cardiovascular Diseases-comprise-Peripheral Arterial Disease', 'Atrial Fibrillation-recognized-Cerebral Infarction', 'Atrial Fibrillation-disable-Cerebral Infarction', 'Pneumonia-result-Pneumococcal Infections', 'Psychomotor Disorders-explain-Leukoencephalopathies', 'Alzheimer Disease-outline-Dementia', 'Muscle Weakness-related-Osteoporosis', 'Muscle Weakness-collected-Osteoporosis', 'Obesity-drive-Diabetes Mellitus', 'Osteoporosis-related-Sarcopenia', 'Osteoporosis-related-Fractures, Bone', 'Penile Neoplasms-remain-Neoplasms', 'Pain-associate-Obesity', 'Obesity-associate-Pain', 'Carcinoma, Hepatocellular-associated-Death', 'Death-associated-Carcinoma, Hepatocellular', 'Osteomyelitis-associated-Atrial Fibrillation', 'Atrial Fibrillation-associated-Osteomyelitis', 'HIV Infections-reach-Infections', 'Parkinson Disease, Secondary-affect-Hydrocephalus', 'Death-identify-Hip Fractures', 'Death-treated-Aortic Valve Stenosis', 'Kidney Diseases-increase-Acute Kidney Injury', 'Diabetes Mellitus-act-Tuberculosis', 'Hyperlipidemias-associated-Obesity', 'Obesity-associated-Hyperlipidemias', 'Fractures, Compression-caused-Osteoporosis', 'Diabetes Mellitus, Type 2-compare-Alzheimer Disease', 'Ventricular Dysfunction, Left-associated-Stroke', 'Stroke-associated-Ventricular Dysfunction, Left', 'Ventricular Dysfunction, Left-associated-Death', 'Death-associated-Ventricular Dysfunction, Left', 'Ventricular Dysfunction, Left-associated-Cerebral Infarction', 'Cerebral Infarction-associated-Ventricular Dysfunction, Left', 'Dyslipidemias-modified-HIV Infections', 'Hernia-carry-Death', 'Infections-associated-Ulcer', 'Ulcer-associated-Infections', 'Ulcer-become-Obesity', 'Atrial Fibrillation-use-Death', 'Atrial Fibrillation-appear-Stroke', 'Multiple Sclerosis-work-Memory Disorders', 'Death-defined-Sarcopenia', 'Stroke-cause-Cardiovascular Diseases', 'Vertigo-grade-Headache Disorders, Secondary', 'Vasospasm, Intracranial-develop-Subarachnoid Hemorrhage', 'Ulcer-result-Death', 'Lung Neoplasms-comprise-End Stage Liver Disease', 'Lung Neoplasms-comprise-Neoplasms', 'Neoplasms-comprise-End Stage Liver Disease', 'Nephritis, Hereditary-progress-Kidney Diseases', 'Unconsciousness-associated-Alzheimer Disease', 'Alzheimer Disease-associated-Unconsciousness', 'Coronary Artery Disease-associated-Osteoporosis', 'Osteoporosis-associated-Coronary Artery Disease', 'Bone Diseases, Metabolic-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-Bone Diseases, Metabolic', 'Osteoporosis-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-Osteoporosis', 'Diabetic Foot-receive-Death', 'Lung Neoplasms-remain-Death', 'Atrial Fibrillation-fail-Stroke', 'Atrial Fibrillation-obtain-Stroke', 'Diabetic Foot-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-Diabetic Foot', 'Diabetes Mellitus-reduce-Pain', 'Carcinoma, Hepatocellular-become-Neoplasms', 'Carcinoma, Hepatocellular-become-Death', 'Renal Insufficiency, Chronic-experience-Myocardial Infarction', 'Proteinuria-predict-Renal Insufficiency, Chronic', 'Vascular Calcification-develop-Diabetes Mellitus', 'Vascular Calcification-develop-Renal Insufficiency, Chronic', 'Hepatitis B-contribute-Death', 'Albuminuria-predict-Death', 'Optic Neuropathy, Ischemic-cause-Vision Disorders', 'Digestive System Neoplasms-associated-Death', 'Death-associated-Digestive System Neoplasms', 'Breast Neoplasms-account-Neoplasms', 'Osteoporosis-assess-Fractures, Bone', 'Fragile X Syndrome-known-Neurodegenerative Diseases', 'Breast Neoplasms-spare-Neoplasms', 'Neoplasm Metastasis-performed-Death', 'Hypercholesterolemia-undergo-Carcinoma, Hepatocellular', 'Cardiovascular Diseases-undergo-Carcinoma, Hepatocellular', 'Diabetes Mellitus-undergo-Carcinoma, Hepatocellular', 'Colorectal Neoplasms-develop-Neoplasm Metastasis', 'Charles Bonnet Syndrome-suffer-Vision Disorders', 'Charles Bonnet Syndrome-tend-Hallucinations', 'Delirium-affect-Dementia', 'Obesity-observed-Arthritis, Rheumatoid', 'Infections-avoid-Airway Obstruction', 'Thyroid Diseases-develop-Renal Insufficiency, Chronic', 'Intellectual Disability-associated-Death', 'Death-associated-Intellectual Disability', 'Pain-increase-Osteoarthritis', 'Edema-increase-Osteoarthritis', 'Carcinoma, Intraductal, Noninfiltrating-undergo-Breast Neoplasms', 'Intracranial Arteriosclerosis-associated-Alzheimer Disease', 'Alzheimer Disease-associated-Intracranial Arteriosclerosis', 'Arteriolosclerosis-associated-Alzheimer Disease', 'Alzheimer Disease-associated-Arteriolosclerosis', 'Hemorrhage-present-Cerebral Infarction', 'Hemolytic-Uremic Syndrome-known-Acute Kidney Injury', 'Coronary Artery Disease-seen-Hemorrhage', 'Atrial Fibrillation-benefit-Death', 'Cardiovascular Diseases-share-Hypertension', 'Carcinoma, Non-Small-Cell Lung-undergo-Neoplasms', 'Cardiovascular Diseases-share-Obesity', 'Cardiovascular Diseases-share-Diabetes Mellitus', 'Drug Overdose-associated-Coma', 'Coma-associated-Drug Overdose', 'Drug Overdose-associated-Pneumonia, Aspiration', 'Pneumonia, Aspiration-associated-Drug Overdose', 'Drug Overdose-associated-Respiratory Insufficiency', 'Respiratory Insufficiency-associated-Drug Overdose', 'Drug Overdose-associated-Death', 'Death-associated-Drug Overdose', 'Metabolic Syndrome-associated-Bone Diseases', 'Bone Diseases-associated-Metabolic Syndrome', 'Chronic Disease-compared-Fatigue', 'Chronic Disease-explain-Fatigue', 'Osteoarthritis-associated-Obesity', 'Obesity-associated-Osteoarthritis', 'Osteoarthritis-found-Obesity', 'Osteoarthritis-divided-Obesity', 'Obesity-compare-Osteoarthritis', 'Critical Illness-associated-Death', 'Death-associated-Critical Illness', 'Alzheimer Disease-play-Inflammation', 'Eclampsia-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-Eclampsia', 'Multiple Sclerosis-show-Atrophy', 'Gingival Hemorrhage-found-Calculi', 'Multiple Sclerosis-associated-Drug-Related Side Effects and Adverse Reactions', 'Drug-Related Side Effects and Adverse Reactions-associated-Multiple Sclerosis', 'Osteoarthritis-fall-Cardiac Output, Low', 'Atrophy-associated-Drug-Related Side Effects and Adverse Reactions', 'Drug-Related Side Effects and Adverse Reactions-associated-Atrophy', 'End Stage Liver Disease-enrolled-Hepatitis B', 'Cerebral Infarction-caused-Intracranial Arteriosclerosis', 'Cerebral Infarction-caused-Coronary Artery Disease', 'Intracranial Arteriosclerosis-caused-Coronary Artery Disease', 'Delirium-test-Dementia', 'Malocclusion-associated-Hernia, Hiatal', 'Hernia, Hiatal-associated-Malocclusion', 'Osteoarthritis-affect-Musculoskeletal Diseases', 'Dementia-associated-Occupational Stress', 'Occupational Stress-associated-Dementia', 'Hyponatremia-associated-Hip Fractures', 'Hip Fractures-associated-Hyponatremia', 'Anemia-related-Chronic Disease', 'Anemia-related-Kidney Failure, Chronic', 'Delirium-predict-Hip Fractures', 'Anemia-related-Arthritis', 'Anemia-related-Neoplasms', 'Hip Fractures-produce-Death', 'Fractures, Bone-produce-Death', 'Hip Fractures-occur-Fragile X Syndrome', 'Cerebral Small Vessel Diseases-involve-Carotid Artery Injuries', 'Hypertension-induced-Cerebrovascular Disorders', 'Hypertension-underlie-Cerebrovascular Disorders', 'Cerebral Small Vessel Diseases-characterized-Hypertrophy', 'Hemorrhage-contribute-Atrial Fibrillation', 'Carotid Artery Injuries-characterized-Hypertrophy', 'Cerebrovascular Disorders-mediated-Hypertension', 'Skin Diseases-give-Occupational Diseases', 'Myocardial Infarction-increase-Stroke', 'Stroke-assessed-Cerebral Infarction', 'Cerebral Infarction-undergo-Dementia', 'Death-increased-Brain Injuries, Traumatic', 'Stroke-undergo-Dementia', 'Neoplasms-demonstrate-Lung Neoplasms', 'Renal Insufficiency, Chronic-affect-Death', 'Diabetes Mellitus, Type 2-associated-Coronary Artery Disease', 'Coronary Artery Disease-associated-Diabetes Mellitus, Type 2', 'Fractures, Bone-compare-Osteoarthritis', 'Diabetes Mellitus, Type 2-enrolled-Diabetes Mellitus', 'Mobility Limitation-associated-Hearing Loss', 'Hearing Loss-associated-Mobility Limitation', 'Mobility Limitation-perceive-Hearing Loss', 'Osteoarthritis, Hip-compare-Osteoarthritis', 'Hearing Loss-implicated-Death', 'Neoplasms-follow-Cardiovascular Diseases', 'Long QT Syndrome-provide-Death', 'Long QT Syndrome-provide-Cardiovascular Diseases', 'Learning Disabilities-linked-Atrophy', 'Dementia-recorded-Death', 'Dengue-extracted-Communicable Diseases', 'Back Pain-represent-Muscle Weakness', 'Drug Hypersensitivity-associated-Death', 'Death-associated-Drug Hypersensitivity', 'Hypertension-diagnosed-Diabetes Mellitus', 'Hypertension-diagnosed-Obesity', 'Hypertension-diagnosed-Renal Insufficiency, Chronic', 'Drug Hypersensitivity-defined-Heart Arrest', 'Hypertension-diagnosed-Coronary Artery Disease', 'Hypertension-diagnosed-Heart Failure', 'Dementia-occur-Stroke', 'Cerebral Hemorrhage-include-Dementia', 'Sleep Wake Disorders-recognized-Metabolic Syndrome', 'Sleep Wake Disorders-coexist-Metabolic Syndrome', 'Sleep Wake Disorders-coexist-Hypertension', 'Alzheimer Disease-associated-Neurogenic Inflammation', 'Neurogenic Inflammation-associated-Alzheimer Disease', 'Fractures, Compression-related-Osteoporosis', 'Hypoxia-cause-Lung Diseases', 'Obesity-associated-Heart Failure', 'Heart Failure-associated-Obesity', 'Hypoxia-cause-Hypertension, Pulmonary', 'Infections-include-Communicable Diseases', 'Neoplasms-associated-Alzheimer Disease', 'Alzheimer Disease-associated-Neoplasms', 'Obesity, Metabolically Benign-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-Obesity, Metabolically Benign', 'Carcinoma, Non-Small-Cell Lung-use-Drug-Related Side Effects and Adverse Reactions', 'Vision Disorders-occur-Alzheimer Disease', 'Kidney Diseases-play-HIV Infections', 'Breast Neoplasms-analyzed-Neoplasms', 'Coronary Artery Disease-associated-Obesity', 'Obesity-associated-Coronary Artery Disease', 'Inflammation-prevent-Atherosclerosis', 'Prostatic Neoplasms-compared-Neoplasms', 'Corneal Diseases-described-Wounds and Injuries', 'Spinal Fractures-include-Wounds and Injuries', 'Dementia-detect-Delirium', 'Spinal Cord Injuries-include-Wounds and Injuries', 'Atrophy-become-Voice Disorders', 'Death-measure-Leg Injuries', 'Diabetes Mellitus-associated-Peripheral Arterial Disease', 'Peripheral Arterial Disease-associated-Diabetes Mellitus', 'Peripheral Arterial Disease-associated-Prediabetic State', 'Prediabetic State-associated-Peripheral Arterial Disease', 'Brain Infarction-prevent-Dementia, Vascular', 'Lung Diseases-associated-Death', 'Death-associated-Lung Diseases', 'Cerebral Amyloid Angiopathy-characterize-Dementia', 'Sinusitis-associated-Asthma', 'Asthma-associated-Sinusitis', 'Obesity-associated-Asthma', 'Asthma-associated-Obesity', 'Cancer Pain-report-Pain', 'Pain-comprise-Cancer Pain', 'Cerebral Hemorrhage-account-Stroke', 'Kidney Diseases-contribute-Anemia', 'Pancreatic Intraductal Neoplasms-defined-Pancreatic Neoplasms', 'Hypertension-associated-Delirium', 'Delirium-associated-Hypertension', 'Tachycardia-associated-Delirium', 'Delirium-associated-Tachycardia', 'Arteriovenous Fistula-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-Arteriovenous Fistula', 'Prostatic Neoplasms-associated-Nervous System Diseases', 'Nervous System Diseases-associated-Prostatic Neoplasms', 'Metabolic Syndrome-correlated-Diabetes Mellitus', 'Metabolic Syndrome-correlated-Cardiovascular Diseases', 'Stroke-involve-Cerebral Hemorrhage', 'Arthritis-follow-Hypertension', 'Arthritis-follow-Neoplasms', 'Pulmonary Disease, Chronic Obstructive-explained-Inflammation', 'Precursor Cell Lymphoblastic Leukemia-Lymphoma-treat-Endocrine System Diseases', 'Osteoporosis-approximate-Fractures, Bone', 'Hip Fractures-approximate-Fractures, Bone', 'Atrial Fibrillation-increase-Cerebral Infarction', 'Arrhythmias, Cardiac-increase-Cerebral Infarction', 'Neoplasms-reduced-Parkinson Disease', 'Parkinson Disease-compare-Neoplasms', 'Anophthalmos-cause-Vision Disorders', 'Tuberculosis, Spinal-remain-Kyphosis', 'Hip Fractures-represent-Death', 'Alzheimer Disease-contribute-Neurodegenerative Diseases', 'Metabolic Syndrome-associated-Polyneuropathies', 'Polyneuropathies-associated-Metabolic Syndrome', 'Arthritis-associated-Dementia', 'Dementia-associated-Arthritis', 'Rheumatic Diseases-follow-Communicable Diseases', 'Aortic Diseases-associated-Alzheimer Disease', 'Alzheimer Disease-associated-Aortic Diseases', 'Memory Disorders-induced-Alzheimer Disease', 'Parkinson Disease-lead-Gait Disorders, Neurologic', 'Alzheimer Disease-characterized-Memory Disorders', 'Carcinoma, Basal Cell-excised-Tongue, Fissured', 'Infections-cause-Lung Diseases', 'Nocturia-associated-Death', 'Death-associated-Nocturia', 'Pancreatic Neoplasms-represent-Neoplasms', 'Pancreatic Neoplasms-lead-Death', 'Neoplasms-lead-Death', 'Nocturia-associated-Sleep Initiation and Maintenance Disorders', 'Sleep Initiation and Maintenance Disorders-associated-Nocturia', 'Intracranial Hemorrhage, Hypertensive-associated-Myocardial Infarction', 'Myocardial Infarction-associated-Intracranial Hemorrhage, Hypertensive', 'Hypertension-investigated-Atrial Fibrillation', 'Myocardial Infarction-prescribed-Infarction', 'Chemical and Drug Induced Liver Injury-investigated-Atrial Fibrillation', 'Stroke-investigated-Atrial Fibrillation', 'HIV Infections-reflect-Neoplasms', 'Asthma-associated-Sleep Wake Disorders', 'Sleep Wake Disorders-associated-Asthma', 'Sleep Wake Disorders-compare-Signs and Symptoms, Respiratory', 'Sleep Wake Disorders-report-Signs and Symptoms, Respiratory', 'Mitral Valve Stenosis-defined-Calcinosis', 'Osteoarthritis-administered-Knee Injuries', 'Death-undergo-Femoral Neck Fractures', 'Hypertension-live-Diabetes Mellitus, Type 2', 'Diabetes Mellitus, Type 2-live-Death', 'Diabetes Mellitus, Type 2-associated-Death', 'Death-associated-Diabetes Mellitus, Type 2', 'Atherosclerosis-evaluate-Death', 'Atherosclerosis-evaluate-Dementia', 'Neoplasms-resemble-Breast Neoplasms', 'Atherosclerosis-evaluate-Coronary Artery Disease', 'Crohn Disease-identify-Colitis, Ulcerative', 'Metabolic Syndrome-associated-Dementia', 'Dementia-associated-Metabolic Syndrome', 'Hearing Loss-detect-Neoplasms', 'Chronic Pain-invited-Pain', 'Stroke-diagnosed-Aphasia', 'Pelvic Neoplasms-compare-Hip Fractures', 'Pelvic Neoplasms-compare-Fractures, Bone', 'Fractures, Bone-compare-Hip Fractures', 'Fractures, Bone-compare-Pelvic Neoplasms', 'Death-used-Heart Valve Diseases', 'Death-examine-Heart Valve Diseases', 'Low Back Pain-improve-Pain', 'Infections-cause-Death', 'Obesity-observed-Stroke', 'Sarcopenia-observed-Stroke', 'Pneumococcal Infections-prevent-Pneumonia', 'Malnutrition-observed-Stroke', 'Hypothyroidism-associated-Alzheimer Disease', 'Alzheimer Disease-associated-Hypothyroidism', 'Hyperthyroidism-associated-Alzheimer Disease', 'Alzheimer Disease-associated-Hyperthyroidism', 'Colonic Polyps-increase-Polyps', 'Postoperative Complications-follow-Urinary Bladder Neoplasms', 'Adrenal Insufficiency-link-Cardiovascular Diseases', 'Adrenal Insufficiency-link-Osteoporotic Fractures', 'Sarcopenia-decrease-Obesity', 'Obesity-receive-Sarcopenia', 'Renal Insufficiency, Chronic-underlie-Pulmonary Disease, Chronic Obstructive', 'Pulmonary Disease, Chronic Obstructive-associated-Renal Insufficiency, Chronic', 'Renal Insufficiency, Chronic-associated-Pulmonary Disease, Chronic Obstructive', 'Pulmonary Disease, Chronic Obstructive-account-Death', 'Wounds and Injuries-linked-Death', 'Death-exhibit-Hip Fractures', 'Hypertension-under-reported-Dementia', 'Infections-related-Neoplasms', 'Myotonic Dystrophy-exacerbate-Parkinson Disease', 'Choledocholithiasis-combined-Gallstones', 'Sleep Wake Disorders-represent-Dementia', 'Atherosclerosis-associated-HIV Infections', 'HIV Infections-associated-Atherosclerosis', 'Gingivitis-associated-Periodontitis', 'Periodontitis-associated-Gingivitis', 'Fatigue-feel-Death', 'Inflammation-use-Chronic Disease', 'Atrophy-identify-Urinary Bladder, Overactive', 'Inflammation-use-Cardiovascular Diseases', 'Hypoxia-associated-Dementia', 'Dementia-associated-Hypoxia', 'Hypoxia-contribute-Canavan Disease', 'Sleep Wake Disorders-contribute-Canavan Disease', 'Glucose Metabolism Disorders-play-Inflammation', 'Epilepsy-include-Seizures', 'Epilepsy-include-Status Epilepticus', 'Atrial Fibrillation-occur-Heart Diseases', 'Vision Disorders-measured-Blindness', 'Cardiac Output, Low-defined-Fractures, Bone', 'Cardiac Output, Low-result-Fractures, Bone', 'Cardiac Output, Low-defined-Wounds and Injuries', 'Pleural Effusion-differ-Pleural Effusion, Malignant', 'Pleural Effusion-distinguish-Pleural Effusion, Malignant', 'Immunologic Deficiency Syndromes-linked-Dementia', 'Weight Loss-increase-Death', 'Obesity-involved-Glucose Metabolism Disorders', 'Metabolic Syndrome-pose-Death', 'Non-alcoholic Fatty Liver Disease-related-Coronary Artery Disease', 'Parkinson Disease, Secondary-recruited-Movement Disorders', 'Parkinson Disease, Secondary-randomised-Constipation', 'Parkinson Disease, Secondary-manage-Constipation', 'Movement Disorders-manage-Constipation', 'Wounds and Injuries-evaluate-Fractures, Bone', 'Intermittent Claudication-suffer-Spinal Stenosis', 'Intermittent Claudication-experience-Pain', 'Hyperalgesia-assess-Pain', 'Weight Loss-malnourished-Malnutrition', 'Death-associated-Breast Neoplasms', 'Breast Neoplasms-associated-Death', 'Death-follow-Hernia, Hiatal', 'Death-reduce-Arrhythmias, Cardiac', 'Ischemia-reduce-Arrhythmias, Cardiac', 'Sleep Wake Disorders-predicted-Obesity', 'Neuromuscular Junction Diseases-associated-Back Pain', 'Back Pain-associated-Neuromuscular Junction Diseases', 'Neuromuscular Junction Diseases-vary-Back Pain', 'Alzheimer Disease-make-Neurodegenerative Diseases', 'Vitelliform Macular Dystrophy-lead-Vision Disorders', 'Corneal Diseases-result-Vision Disorders', 'Stroke, Lacunar-admitted-Stroke', 'Vascular Calcification-associated-Renal Insufficiency, Chronic', 'Renal Insufficiency, Chronic-associated-Vascular Calcification', 'Death-result-Arbovirus Infections', 'Breast Neoplasms-derive-Drug-Related Side Effects and Adverse Reactions', 'Diabetes Mellitus-included-Dementia', 'Peripheral Arterial Disease-mediate-Frailty', 'Asthma-resemble-Pulmonary Disease, Chronic Obstructive', 'Drug Hypersensitivity-precede-Headache Disorders, Secondary', 'Death-occur-Stroke', 'Glomerulonephritis-followed-Kidney Failure, Chronic', 'Diabetes Mellitus-followed-Kidney Failure, Chronic', 'Stroke-associated-Cerebrovascular Disorders', 'Cerebrovascular Disorders-associated-Stroke', 'Bone Diseases-seen-Renal Insufficiency, Chronic', 'Neoplasms-derived-Death', 'Intestinal Neoplasms-include-Neoplasms', 'Neoplasms-comprise-Carcinoma, Squamous Cell', 'Arthritis-included-Osteoarthritis', 'Fractures, Bone-included-Osteoarthritis', 'Metabolic Syndrome-predict-Cardiovascular Diseases', 'Metabolic Syndrome-predict-Diabetes Mellitus', 'Alcoholism-associated-Sleep Wake Disorders', 'Sleep Wake Disorders-associated-Alcoholism', 'Erectile Dysfunction-predict-Cardiovascular Diseases', 'Pain-sustain-Femoral Neck Fractures', 'Fistula-become-Neurologic Manifestations', 'Constriction, Pathologic-become-Neurologic Manifestations', 'Atrioventricular Block-differ-Graft vs Host Disease', 'Hypogonadism-associated-Obesity', 'Obesity-associated-Hypogonadism', 'Hypogonadism-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-Hypogonadism', 'Muscular Dystrophy, Duchenne-cause-Muscle Weakness', 'Neuromuscular Diseases-cause-Muscle Weakness', 'Muscle Weakness-report-Deglutition Disorders', 'Dementia-use-Cardiovascular Diseases', 'Sleep Apnea Syndromes-increase-Stroke', 'Deglutition Disorders-worsen-Muscular Dystrophy, Duchenne', 'Encephalitis, Tick-Borne-administered-Arthritis, Rheumatoid', 'Hip Fractures-limit-Fatigue', 'Breast Neoplasms-take-Death', 'Death-occur-Neoplasms', 'Hematologic Neoplasms-impose-Hypotension', 'Kidney Diseases-include-Diabetes Mellitus, Type 2', 'Delirium-predict-Death', 'Sarcopenia-function-Death', 'Memory Disorders-recruited-Alzheimer Disease', 'Gait Disorders, Neurologic-associated-Osteoporosis', 'Osteoporosis-associated-Gait Disorders, Neurologic', 'Death-occur-Tuberculosis', 'Tibial Fractures-accompanied-Oculocerebrorenal Syndrome', 'Tibial Fractures-accompanied-Compartment Syndromes', 'Oculocerebrorenal Syndrome-accompanied-Compartment Syndromes', 'Hypertension-comprise-Heart Failure', 'Hypertension-comprise-Coronary Artery Disease', 'Hypertension-comprise-Atrial Fibrillation', 'Sleep Wake Disorders-explain-Sleep Deprivation', 'Sleep Wake Disorders-associated-Sleep Deprivation', 'Sleep Deprivation-associated-Sleep Wake Disorders', 'Chronic Disease-act-Mastocytosis, Systemic', 'Respiratory Tract Infections-comprise-Death', 'Hypertension-contribute-Atherosclerosis', 'Dyslipidemias-contribute-Atherosclerosis', 'Diabetes Mellitus-contribute-Atherosclerosis', 'Carotid Artery Diseases-include-Atherosclerosis', 'Genetic Diseases, Inborn-cause-Cerebellar Ataxia', 'Genetic Diseases, Inborn-cause-Neoplasms', 'Chronic Disease-targeted-Colorectal Neoplasms', 'Neoplasms-targeted-Colorectal Neoplasms', 'Leukemia, Myelogenous, Chronic, BCR-ABL Positive-include-Leukemia', 'Leukemia, Lymphocytic, Chronic, B-Cell-occur-Death', 'Pancreatic Neoplasms-poise-Neoplasms', 'Pulmonary Disease, Chronic Obstructive-considered-Death', 'Hypogonadism-represent-Erectile Dysfunction', 'Neurodegenerative Diseases-characterized-Neurologic Manifestations', 'Neurodegenerative Diseases-characterized-Nerve Degeneration', 'Neurologic Manifestations-characterized-Nerve Degeneration', 'Diabetes Mellitus-become-Hypoglycemia', 'Diabetes Mellitus-become-Weight Gain', 'Neurologic Manifestations-cure-Neurodegenerative Diseases', 'Femoral Neck Fractures-lead-Death', 'Carotid Stenosis-associated-Atherosclerosis', 'Atherosclerosis-associated-Carotid Stenosis', 'Glycogen Storage Disease Type II-predict-Death', 'Glycogen Storage Disease Type II-predict-Stroke', 'Stroke-exclude-Arachnoiditis', 'Stroke-contribute-Death', 'Astigmatism-undergo-Cataract', 'Hypothyroidism-known-Psychoses, Substance-Induced', 'Hypothyroidism-known-Myxedema', 'Dementia-known-Psychoses, Substance-Induced', 'Dementia-known-Myxedema', 'Appendicitis-treat-Obesity', 'Psychoses, Substance-Induced-known-Myxedema', 'Myxedema-kept-Psychoses, Substance-Induced', 'Myxedema-kept-Hypothyroidism', 'Cerebrovascular Disorders-defined-Heart Failure', 'Bone Marrow Diseases-use-Myocardial Infarction', 'Bone Marrow Diseases-treat-Myocardial Infarction', 'Diabetes Mellitus, Type 2-recognize-Dementia', 'Diabetes Mellitus, Type 2-observed-Hypoglycemia', 'Dementia-observed-Hypoglycemia', 'Peripheral Vascular Diseases-obtained-Communicable Diseases', 'Dehydration-associated-Death', 'Death-associated-Dehydration', 'Renal Insufficiency, Chronic-increase-Death', 'Cardiovascular Diseases-occur-Myocardial Infarction', 'Alzheimer Disease-selected-Dementia', 'Death-occur-Myocardial Infarction', 'Hallucinations-relate-Psychoses, Substance-Induced', 'Hallucinations-associated-Psychoses, Substance-Induced', 'Psychoses, Substance-Induced-associated-Hallucinations', 'Hearing Loss, Central-divide-Tinnitus', 'Cerebral Amyloid Angiopathy-related-Alzheimer Disease', 'Tinnitus-hear-Hearing Loss', 'Multiple Organ Failure-associated-Hematologic Neoplasms', 'Hematologic Neoplasms-associated-Multiple Organ Failure', 'Death-diagnosed-Hematologic Neoplasms', 'Cardiac Output, Low-mediated-Muscle Weakness', 'Death, Sudden-include-Cardiovascular Diseases', 'Parkinson Disease-studied-Neurodegenerative Diseases', 'Coronary Artery Disease-remain-Death', 'Infections-cause-Respiratory Tract Diseases', 'Chronic Disease-complicated-HIV Infections', 'Neurocysticercosis-categorize-Subarachnoid Hemorrhage', 'Death-complicated-HIV Infections', 'Stroke-estimated-Communicable Diseases', 'Death-estimated-Communicable Diseases', 'Osteoarthritis-experience-Pain', 'Sleep Wake Disorders-analyzed-Osteoporotic Fractures', 'Stroke-related-Atrial Fibrillation', 'Frailty-exhibit-Death', 'Airway Obstruction-identify-Heart Failure', 'Airway Obstruction-identify-Ventricular Dysfunction, Left', 'Chemical and Drug Induced Liver Injury-result-Heart Failure', 'Cerebral Infarction-spend-Leukoencephalopathies', 'Headache Disorders, Secondary-associated-Multiple Sclerosis', 'Multiple Sclerosis-associated-Headache Disorders, Secondary', 'Pain-differ-Delirium', 'Pain-reported-Neoplasms', 'Delirium-reported-Neoplasms', 'Hereditary Breast and Ovarian Cancer Syndrome-associated-Dementia', 'Dementia-associated-Hereditary Breast and Ovarian Cancer Syndrome', 'Intervertebral Disc Degeneration-lead-Back Pain', 'Metabolic Diseases-live-Diabetes Mellitus', 'Metabolic Diseases-live-Cardiovascular Diseases', 'Bone Neoplasms-result-Congenital, Hereditary, and Neonatal Diseases and Abnormalities', 'Neoplasms-result-Congenital, Hereditary, and Neonatal Diseases and Abnormalities', 'Death-known-Coronary Artery Disease', 'Diabetes Mellitus-undergo-Fatty Liver', 'Diabetes Mellitus-include-Fatty Liver', 'HIV Infections-progress-Acquired Immunodeficiency Syndrome', 'Diabetes Mellitus-undergo-Liver Cirrhosis', 'Diabetes Mellitus-include-Liver Cirrhosis', 'Hypoglycemia-include-Diabetes Mellitus, Type 2', 'Infections-progress-Acquired Immunodeficiency Syndrome', 'Diabetes Mellitus-undergo-Inflammation', 'Diabetes Mellitus-include-Inflammation', 'Leukoencephalopathies-related-Stroke', 'Atrial Fibrillation-confer-Stroke', 'Atrial Fibrillation-confer-Heart Failure', 'Arrhythmias, Cardiac-confer-Stroke', 'Arrhythmias, Cardiac-confer-Heart Failure', 'Epilepsy-develop-Cerebrovascular Disorders', 'Alzheimer Disease-base-Amyloidosis', 'Alzheimer Disease-base-Neurodegenerative Diseases', 'Bone Marrow Failure Disorders-include-Myelodysplastic Syndromes', 'Bone Marrow Failure Disorders-form-Myelodysplastic Syndromes', 'Hearing Loss-associated-Cardiac Output, Low', 'Cardiac Output, Low-associated-Hearing Loss', 'Hearing Loss-fall-Cardiac Output, Low', 'Diabetes Mellitus, Type 1-demonstrate-Acute Kidney Injury', 'Diabetes Mellitus, Type 2-demonstrate-Acute Kidney Injury', 'Retinitis-observed-Glaucoma', 'Retinal Vein Occlusion-followed-Retinal Artery Occlusion', 'Diabetes Mellitus-suffer-Acute Kidney Injury', 'Diabetes Mellitus, Type 1-suffer-Acute Kidney Injury', 'Neoplasms-confronted-Urinary Bladder Neoplasms', 'Parkinson Disease-hear-Tinnitus', 'Parkinson Disease-hear-Blindness', 'Parkinson Disease-hear-Vertigo', 'Parkinson Disease-hear-Scleroderma, Systemic', 'Parkinson Disease-hear-Epilepsy', 'Dementia-hear-Tinnitus', 'Dementia-hear-Blindness', 'Parkinson Disease-suffer-Dementia', 'Dementia-hear-Vertigo', 'Dementia-hear-Scleroderma, Systemic', 'Dementia-hear-Epilepsy', 'Stroke-hear-Tinnitus', 'Stroke-hear-Blindness', 'Stroke-hear-Vertigo', 'Stroke-hear-Scleroderma, Systemic', 'Memory Disorders-leading-Neoplasms', 'Memory Disorders-leading-Infections', 'Stroke-hear-Epilepsy', 'Alzheimer Disease-represent-Nervous System Diseases', 'Hydrocephalus-resemble-Brain Diseases', 'Brain Injuries, Traumatic-associated-Alzheimer Disease', 'Alzheimer Disease-associated-Brain Injuries, Traumatic', 'Alzheimer Disease-base-Brain Injuries, Traumatic', 'Pain-increase-Fractures, Bone', 'Blindness-associated-Death', 'Death-associated-Blindness', 'Stroke-collected-Ischemia', 'Stroke-collected-Myocardial Infarction', 'Stroke-collected-Diabetes Mellitus', 'Stroke-collected-Hypertension', 'Chronic Disease-range-Hypertension', 'Stroke-range-Atrial Fibrillation', 'Death-consist-Inflammation', 'Diabetes Mellitus-occur-Glucose Intolerance', 'Atrial Fibrillation-accompanied-Cerebrovascular Disorders', 'Ataxia Telangiectasia-consist-Genetic Diseases, Inborn', 'Genetic Diseases, Inborn-consist-Cerebellar Ataxia', 'Hepatitis C-result-Death', 'Hepatitis C-result-End Stage Liver Disease', 'Hepatitis C-result-Carcinoma, Hepatocellular', 'Genetic Diseases, Inborn-consist-Immunologic Deficiency Syndromes', 'Genetic Diseases, Inborn-consist-Infections', 'Telangiectasis-consist-Genetic Diseases, Inborn', 'Genetic Diseases, Inborn-consist-Neoplasms', 'Osteoporosis-include-Hallucinations', 'Muscular Atrophy-include-Hallucinations', 'Metabolic Syndrome-include-Metabolic Diseases', 'Infarction-associated-Cerebrovascular Disorders', 'Cerebrovascular Disorders-associated-Infarction', 'Dry Eye Syndromes-base-Peritoneal Neoplasms', 'Dry Eye Syndromes-include-Corneal Diseases', "Sjogren's Syndrome-include-Corneal Diseases", 'Respiratory Insufficiency-administered-Pneumonia', "Sjogren's Syndrome-lead-Xerostomia", "Sjogren's Syndrome-lead-Dry Eye Syndromes", 'Parkinsonian Disorders-documented-Parkinson Disease', 'Parkinsonian Disorders-assessed-Parkinson Disease', 'HIV Infections-predict-Cardiovascular Diseases', 'Neoplasms-involved-Inflammation', 'Essential Tremor-compare-Tremor', 'Sarcopenia-detected-Hip Fractures', 'Muscle Weakness-perform-Sleep Initiation and Maintenance Disorders', 'Wounds and Injuries-sustain-Hip Fractures', 'Hyperphosphatemia-suffer-Calcinosis', 'Atrial Fibrillation-study-End Stage Liver Disease', 'Rupture-associated-Aneurysm, Ruptured', 'Aneurysm, Ruptured-associated-Rupture', 'Pain-diagnose-Dementia', 'Urinary Incontinence-include-Pelvic Floor Disorders', 'Fecal Incontinence-include-Pelvic Floor Disorders', 'Dementia-include-Neurodegenerative Diseases', 'Plaque, Amyloid-met-Dementia', 'Cardiac Output, Low-increase-Pain', 'Cardiac Output, Low-increase-Muscle Weakness', 'Mobility Limitation-report-Fatigue', 'Dementia-met-Delirium', 'Fecal Incontinence-associated-Heart Diseases', 'Heart Diseases-associated-Fecal Incontinence', 'Fecal Incontinence-associated-Urinary Incontinence', 'Urinary Incontinence-associated-Fecal Incontinence', 'Obesity-manage-Joint Diseases', 'Acute Pain-manage-Joint Diseases', 'Mobility Limitation-experience-Fatigue', 'Mobility Limitation-hear-Hearing Loss', 'Obesity-reflect-Metabolic Diseases', 'Fatigue-experience-Hearing Loss', 'Lung Injury-cause-Hodgkin Disease', 'Inflammation-contribute-Sarcopenia', 'Death-include-Cardiovascular Diseases', 'Delirium-underlie-Dementia', 'Intracranial Arteriovenous Malformations-pose-Hemorrhage', 'Death-reduce-AIDS-Related Opportunistic Infections', 'Ovarian Diseases-associated-Cardiovascular Abnormalities', 'Cardiovascular Abnormalities-associated-Ovarian Diseases', 'Inflammation-play-Neoplasms', 'Carcinogenesis-related-Inflammation', 'Leukoencephalopathies-found-Aneurysm', 'Pain-identify-Hip Fractures', 'Neoplasm Metastasis-scheduled-Neoplasms', 'Cardiac Output, Low-fall-Wounds and Injuries', 'Cerebral Infarction-related-Atrial Fibrillation', 'Ischemia-related-Atrial Fibrillation', 'Hip Fractures-treated-Hypotension', 'Diabetes Mellitus-confirm-Hypertension', 'Cockayne Syndrome-characterized-Microcephaly', 'Cockayne Syndrome-characterized-Growth Disorders', 'Genetic Diseases, Inborn-characterized-Microcephaly', 'Chronic Pain-associated-Pain', 'Pain-associated-Chronic Pain', 'Genetic Diseases, Inborn-characterized-Growth Disorders', 'Heart Arrest-recognized-Neoplasms', 'Heart Arrest-interfere-Neoplasms', 'Kidney Diseases-associated-Dementia', 'Dementia-associated-Kidney Diseases', 'Hypothyroidism-associated-Hyperthyroidism', 'Hyperthyroidism-associated-Hypothyroidism', 'Communicable Diseases-considered-Fragile X Syndrome', 'Weight Loss-lead-Malnutrition', 'Femoral Neck Fractures-assess-Pain', 'Hip Fractures-report-Pain', 'Thyrotoxicosis-account-Atrial Fibrillation', 'Thyrotoxicosis-account-Osteoporosis', 'Thyrotoxicosis-associated-Atrial Fibrillation', 'Atrial Fibrillation-associated-Thyrotoxicosis', 'Renal Insufficiency, Chronic-diagnosed-Kidney Failure, Chronic', 'Diabetes Mellitus-receive-Tetany', 'Infections-associated-Diabetes Mellitus, Type 2', 'Diabetes Mellitus, Type 2-associated-Infections', 'Fibrosis-associated-Fatty Liver', 'Fatty Liver-associated-Fibrosis', 'Heart Failure-complicate-Hypertension', 'Heart Failure-complicate-Diabetes Mellitus', 'Aortic Diseases-associate-Death', 'Death-associate-Aortic Diseases', 'Aortic Diseases-associate-Wounds and Injuries', 'Wounds and Injuries-associate-Aortic Diseases', 'Polycystic Ovary Syndrome-consist-Obesity', 'Renal Insufficiency, Chronic-transfer-Chronic Disease', 'Renal Insufficiency, Chronic-transfer-Diabetes Mellitus', 'Lymphoma-include-Neoplastic Syndromes, Hereditary', 'Renal Insufficiency, Chronic-transfer-Hypertension', 'Communicable Diseases-transfer-Chronic Disease', 'Communicable Diseases-transfer-Diabetes Mellitus', 'Communicable Diseases-transfer-Hypertension', 'Inflammation-accelerate-Diabetes Mellitus, Type 2', 'Neoplasms-increase-Kidney Neoplasms', 'Hernia-compared-Hernia, Ventral', 'Inflammation-associated-Atherosclerosis', 'Atherosclerosis-associated-Inflammation', 'Aortic Aneurysm, Abdominal-reduce-Rupture', 'Olfaction Disorders-identified-Alzheimer Disease', 'Neoplasms-used-Fractures, Bone', 'Olfaction Disorders-identified-Parkinson Disease', 'Olfaction Disorders-identified-Dementia', 'Death-predict-Neoplasms', 'Pseudotumor Cerebri-evaluate-Vision Disorders', 'Pseudotumor Cerebri-updated-Vestibular Diseases', 'Pseudotumor Cerebri-updated-Anophthalmos', 'Pseudotumor Cerebri-play-Cerebellar Diseases', 'Pseudotumor Cerebri-evaluate-Paralysis', 'Pseudotumor Cerebri-evaluate-Cerebellar Diseases', 'Heart Failure-associated-Myocardial Infarction', 'Myocardial Infarction-associated-Heart Failure', 'Pulmonary Disease, Chronic Obstructive-include-Respiratory Insufficiency', 'Vision Disorders-play-Cerebellar Diseases', 'Vision Disorders-play-Paralysis', 'Vestibular Diseases-play-Cerebellar Diseases', 'Vestibular Diseases-evaluate-Paralysis', 'Hypertension, Pulmonary-characterized-Stenosis, Pulmonary Artery', 'Hypertension, Pulmonary-carry-Death', 'Anophthalmos-play-Cerebellar Diseases', 'Stenosis, Pulmonary Artery-increase-Death', 'Anophthalmos-evaluate-Paralysis', 'Carotid Artery Diseases-enrolled-Stroke', 'Respiratory Tract Diseases-include-Respiratory Insufficiency', 'Respiratory Tract Diseases-include-Airway Obstruction', 'Pulmonary Disease, Chronic Obstructive-include-Airway Obstruction', 'Brain Injuries-result-Stroke', 'Tremor-show-Death', 'Polyneuropathies-estimated-Diabetes Mellitus, Type 2', 'Epilepsy-associated-Death', 'Death-associated-Epilepsy', 'Hypothalamic Neoplasms-reach-Cataract', 'Brain Diseases-associated-Death', 'Death-associated-Brain Diseases', 'Death-ascribed-Epilepsy', 'Hyperuricemia-protect-Fractures, Bone', 'Anemia-find-Stomach Neoplasms', 'Neoplasms-experience-Death', 'Heart Failure-associated-Chronic Disease', 'Chronic Disease-associated-Heart Failure', 'Aortic Diseases-associated-Albuminuria', 'Albuminuria-associated-Aortic Diseases', 'Hypertension-randomized-Cardiovascular Diseases', 'Hypertension-divided-Hypotension, Orthostatic', 'Sleep Wake Disorders-defined-Sleepiness', 'Subarachnoid Hemorrhage-show-Death', 'Arrhythmias, Cardiac-diagnosed-Stroke', 'Lung Diseases-involve-Inflammation', 'Lung Diseases-involve-Infections', 'Cystic Fibrosis-involve-Inflammation', 'Cystic Fibrosis-involve-Infections', 'Breast Neoplasms, Male-include-Anophthalmos', 'Cerebrovascular Disorders-manifested-Cerebral Infarction', 'Subarachnoid Hemorrhage-experience-Death', 'Osteogenesis Imperfecta-show-Muscle Weakness', 'Hyponatremia-contribute-Fractures, Bone', 'Hyponatremia-contribute-Death', 'Brain Infarction-defined-Infarction', 'Inflammation-provoke-Dilatation, Pathologic', 'Inflammation-induce-Microaneurysm', 'Death-assess-Kidney Failure, Chronic', 'Inflammation-promote-Cerebral Hemorrhage', 'Dilatation, Pathologic-induce-Microaneurysm', 'Dilatation, Pathologic-promote-Cerebral Hemorrhage', 'Microaneurysm-promote-Cerebral Hemorrhage', 'Diabetes Mellitus-develop-Glaucoma, Open-Angle', 'Hypotension, Orthostatic-associated-Cerebral Infarction', 'Cerebral Infarction-associated-Hypotension, Orthostatic', 'Cerebral Infarction-diagnosed-Cerebral Hemorrhage', 'Cerebral Infarction-occur-Cerebral Hemorrhage', 'Hepatitis B, Chronic-lead-Hepatitis', 'Fatty Liver-reported-Metabolic Syndrome', 'Hepatitis B, Chronic-lead-Carcinoma, Hepatocellular', 'Cardiovascular Diseases-develop-Diabetes Mellitus, Type 2', 'Neoplasms-associated-Carcinoma, Squamous Cell', 'Carcinoma, Squamous Cell-associated-Neoplasms', 'Hyperkinesis-lead-Dyspareunia', 'Hyperkinesis-lead-Vulvodynia', 'Hyperkinesis-contribute-Cystitis', 'Dyspareunia-lead-Vaginitis', 'Cystitis-contribute-Vaginitis', 'Crohn Disease-characterized-Necrosis', 'Thrombosis-demonstrate-Hemorrhage', 'Hypothalamic Neoplasms-associated-Hypothalamic Diseases', 'Hypothalamic Diseases-associated-Hypothalamic Neoplasms', 'HIV Infections-turn-Chronic Disease', 'Hearing Loss-increase-Alzheimer Disease', 'Breast Neoplasms-reduce-Death', 'Neoplasms-examined-Death', 'Cushing Syndrome-characterized-Sarcopenia', 'Neoplasms-examined-Lung Neoplasms', 'Cushing Syndrome-characterized-Obesity', 'Cushing Syndrome-characterized-Osteoporosis', 'Atrial Fibrillation-control-Hypertension', 'Stroke-control-Hypertension', 'Hemorrhage-control-Hypertension', 'Cholecystitis, Acute-occur-Gallstones', 'Constipation-associated-Pelvic Floor Disorders', 'Pelvic Floor Disorders-associated-Constipation', 'Femoral Fractures-vary-Wounds and Injuries', 'Arthritis-overlooked-Pain', 'Pain-associate-Joint Diseases', 'Joint Diseases-associate-Pain', 'Cardiovascular Diseases-cause-Death', 'Cardiomyopathy, Hypertrophic-associated-Central Nervous System Diseases', 'Central Nervous System Diseases-associated-Cardiomyopathy, Hypertrophic', 'Cardiomyopathy, Hypertrophic-associated-Death, Sudden', 'Death, Sudden-associated-Cardiomyopathy, Hypertrophic', 'Cardiomyopathy, Hypertrophic-associated-Heart Failure', 'Heart Failure-associated-Cardiomyopathy, Hypertrophic', 'Death, Sudden-include-Central Nervous System Diseases', 'Heart Failure-include-Central Nervous System Diseases', 'Heart Failure-hospitalized-Death', 'Contracture-characterized-Musculoskeletal Diseases', 'Contracture-characterized-Pain', 'Leukemia, Myeloid, Acute-achieve-Fatigue', 'Diabetes Mellitus-predict-Hearing Loss', 'Fistula-occur-Tuberculosis, Pulmonary', 'Sarcopenia-associated-Muscular Dystrophy, Duchenne', 'Muscular Dystrophy, Duchenne-associated-Sarcopenia', 'Leukemia, Myeloid, Acute-associated-Drug-Related Side Effects and Adverse Reactions', 'Drug-Related Side Effects and Adverse Reactions-associated-Leukemia, Myeloid, Acute', 'Neurodegenerative Diseases-associated-Parkinson Disease', 'Parkinson Disease-associated-Neurodegenerative Diseases', 'Obesity-expected-Osteoarthritis', 'Hypertension-contribute-Cardiovascular Diseases', 'Inflammation-contribute-Cardiovascular Diseases', 'Alzheimer Disease-lead-Dementia', 'Neurodegenerative Diseases-characterized-Memory Disorders', 'Neurodegenerative Diseases-characterized-Dementia', 'Memory Disorders-lead-Dementia', 'Rhinitis-suffer-Chronic Disease', 'Breast Neoplasms-experience-Arthralgia', 'Breast Neoplasms-cause-Arthralgia', 'Alzheimer Disease-treat-Headache Disorders, Secondary', 'Olfaction Disorders-play-Parkinson Disease', 'Pulmonary Disease, Chronic Obstructive-associated-Death, Sudden, Cardiac', 'Death, Sudden, Cardiac-associated-Pulmonary Disease, Chronic Obstructive', 'Death-associate-Hypotension', 'Hypotension-associate-Death', 'Diabetes Mellitus-associate-Hypotension', 'Hypotension-associate-Diabetes Mellitus', 'Death-associate-Diabetes Mellitus', 'Diabetes Mellitus-associate-Death', 'Femoral Neck Fractures-exposed-Cardiac Output, Low', 'Diabetes Mellitus-reduce-Foot Ulcer', 'Metabolic Syndrome-reduce-Death', 'Optic Neuropathy, Ischemic-characterized-Blindness', 'Optic Neuropathy, Ischemic-cause-Blindness', 'Infarction-cause-Blindness', 'Hypotension-result-Blindness', 'Optic Neuropathy, Ischemic-result-Blindness', 'Sleep Wake Disorders-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-Sleep Wake Disorders', 'Sleep Wake Disorders-associated-Cardiomyopathy, Hypertrophic', 'Cardiomyopathy, Hypertrophic-associated-Sleep Wake Disorders', 'Aortic Aneurysm, Abdominal-precede-Aneurysm', 'Arrhythmias, Cardiac-occur-Atrial Fibrillation', 'Atrial Fibrillation-associated-Arrhythmias, Cardiac', 'Arrhythmias, Cardiac-associated-Atrial Fibrillation', 'Paraganglioma-present-Tinnitus', 'Paraganglioma-present-Hearing Loss', 'Paraganglioma-manifest-Vertigo', 'Thrombocytosis-develop-Venous Thrombosis', 'Heredodegenerative Disorders, Nervous System-encountered-Neurodegenerative Diseases', 'Death-acknowledged-Anemia', 'Heredodegenerative Disorders, Nervous System-encountered-Dementia', 'Heredodegenerative Disorders, Nervous System-encountered-Stroke', 'Heredodegenerative Disorders, Nervous System-encountered-Headache', 'Atrophy-convert-Alzheimer Disease', 'Pain-relieve-Fractures, Bone', 'Pain-relieve-Osteoporotic Fractures', 'Dementia-live-Death', 'Polyuria-used-Hyponatremia', 'HIV Infections-associated-Cerebral Infarction', 'Cerebral Infarction-associated-HIV Infections', 'Brain Injuries-affect-Heart Arrest', 'Cerebral Amyloid Angiopathy-reflect-Cerebral Hemorrhage', 'Hypertension-reflect-Cerebral Hemorrhage', 'Fractures, Compression-performed-Pain', 'Gastroesophageal Reflux-occur-Diabetes Mellitus', 'Pneumonia of Calves, Enzootic-evaluate-Death', 'Hyperhomocysteinemia-differentiate-Retinal Vein Occlusion', 'Hip Fractures-increase-Hemorrhage', 'Diabetes Mellitus-undergo-Liver Failure', 'Diabetes Mellitus-undergo-Fibrosis', 'Diabetes Mellitus-undergo-Hypertension', 'Anophthalmos-acquire-Cataract', 'Hip Fractures-limited-Osteoporosis', 'Hip Fractures-prevent-Osteoporosis', 'Fractures, Bone-limited-Osteoporosis', 'Oculocerebrorenal Syndrome-caused-Osteoporosis', 'Fractures, Bone-caused-Osteoporosis', 'Sarcopenia-cause-Renal Tubular Transport, Inborn Errors', 'Sarcopenia-cause-Deglutition Disorders', 'Deglutition Disorders-include-Renal Tubular Transport, Inborn Errors', 'Renal Insufficiency, Chronic-include-Chronic Disease', 'Heart Failure-characterized-Death', 'Urinary Tract Infections-lead-Death', 'Bacterial Infections-lead-Death', 'Death-predict-Fractures, Bone', 'Cushing Syndrome-coexist-Hypertension', 'Cushing Syndrome-coexist-Obesity', 'Death-occur-Fractures, Bone', 'Heart Failure-continue-Death', 'Thrombosis-associated-Neoplasms', 'Neoplasms-associated-Thrombosis', 'Neoplasms-include-Venous Thromboembolism', 'Death-alter-Sleep Initiation and Maintenance Disorders', 'Sleep Initiation and Maintenance Disorders-alter-Diabetes Mellitus', 'Sleep Initiation and Maintenance Disorders-alter-Cardiovascular Diseases', 'Shock-protect-Neurodegenerative Diseases', 'Shock-protect-Brain Ischemia', 'Colonic Neoplasms-collected-Inflammatory Bowel Diseases', 'Fibrosis-increased-Kidney Diseases', 'Diabetes Mellitus-undergo-Cardiac Output, Low', 'Diabetes Mellitus-fall-Cardiac Output, Low', 'Osteolysis-represent-Neoplasms', 'Osteolysis-represent-Infections', 'Osteolysis-represent-Wounds and Injuries', 'Hypogonadism-lead-Muscle Weakness', 'Hypogonadism-lead-Protein-Energy Malnutrition', 'Tuberculosis-related-Death', 'Glucose Metabolism Disorders-worsen-Myocardial Infarction', 'Cardiovascular Diseases-worsen-Myocardial Infarction', 'Tuberculosis-compare-Death', 'Stroke-suffer-Dementia', 'Stroke-screened-Syncope', 'Syncope-describe-Stroke', 'Lung Diseases, Obstructive-controlled-Inflammation', 'Osteoporotic Fractures-reveal-Pain', 'Chronic Kidney Disease-Mineral and Bone Disorder-lead-Renal Insufficiency, Chronic', 'Fractures, Bone-reveal-Pain', 'Neoplasms-comprise-Angiomyolipoma', 'Hematoma-detect-Hemorrhage', 'Diabetes Mellitus, Type 2-consult-Erectile Dysfunction', 'Glucose Intolerance-consult-Erectile Dysfunction', 'Atrial Fibrillation-experience-Stroke', 'Obesity-consult-Erectile Dysfunction', 'Death-manifest-Tuberculosis', 'Metabolic Diseases-involved-Erectile Dysfunction', 'Metabolic Diseases-cause-Erectile Dysfunction', 'Coinfection-consult-Erectile Dysfunction', 'Myocardial Infarction-see-Metabolic Syndrome', 'Hypoglycemia-associated-Dementia', 'Dementia-associated-Hypoglycemia', 'Hypoglycemia-associated-Diabetes Mellitus, Type 2', 'Diabetes Mellitus, Type 2-associated-Hypoglycemia', 'Urethral Neoplasms-identified-Neoplasms', 'Urethral Neoplasms-undergo-Neoplasms', 'Death-consider-Myocardial Infarction', 'Diabetes Mellitus-display-Coronary Artery Disease', 'Psychomotor Agitation-increase-Dementia', 'Psychomotor Agitation-elevate-Dementia', 'Immune System Diseases-promote-Inflammation', 'Obesity-show-Seizures', 'Nervous System Diseases-include-Erectile Dysfunction', 'Diabetes Mellitus-include-Erectile Dysfunction', 'Aneurysm-include-Erectile Dysfunction', 'Seizures-associated-Obesity', 'Obesity-associated-Seizures', 'Amyloidosis-include-Alzheimer Disease', 'Atrophy-include-Alzheimer Disease', 'Infections-remain-Obesity', 'Alzheimer Disease-include-Amyloidosis', 'Dementia-witness-Heart Arrest', 'Chronic Disease-affected-Olfaction Disorders', 'Infections-reflect-Renal Insufficiency, Chronic', 'Infections-increase-Renal Insufficiency, Chronic', 'Hyperparathyroidism-linked-Death', 'Rhinitis, Allergic-include-Drug Hypersensitivity', 'Eczema-include-Drug Hypersensitivity', 'Proteinuria-associated-Death', 'Death-associated-Proteinuria', 'Diabetes Mellitus-predict-Dementia', 'Proteinuria-associated-Pneumonia', 'Pneumonia-associated-Proteinuria', 'Proteinuria-associated-Sepsis', 'Sepsis-associated-Proteinuria', 'Proteinuria-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-Proteinuria', 'Death-follow-Pneumonia', 'Death-follow-Sepsis', 'Death-follow-Diabetes Mellitus', 'Eyelid Diseases-correct-Intestinal Pseudo-Obstruction', 'Constriction, Pathologic-associated-Death', 'Death-associated-Constriction, Pathologic', 'Constriction, Pathologic-progress-Death', 'Death-progress-Aortic Valve Stenosis', 'Alzheimer Disease-linked-Neurotoxicity Syndromes', 'Coronary Artery Disease-reduce-Myocardial Infarction', 'Parkinsonian Disorders-associated-Parkinson Disease', 'Parkinson Disease-associated-Parkinsonian Disorders', 'Cardiac Output, Low-cause-Fractures, Bone', 'Sleep Wake Disorders-correlated-Parkinson Disease', 'Skin Diseases-include-Hyperpigmentation', 'Skin Diseases-include-Agnosia', 'Skin Diseases-include-Telangiectasis', 'Death-suggest-Drug Overdose', 'Osteoarthritis-cause-Chronic Pain', 'Pulmonary Disease, Chronic Obstructive-correspond-Muscular Atrophy', 'Liposarcoma-represent-Sarcoma', 'Heart Diseases-lead-Heart Failure', 'Patellofemoral Pain Syndrome-result-Pain', 'Periodontal Diseases-considered-Tooth Loss', 'Periodontitis-considered-Tooth Loss', 'Death-compare-Shock, Cardiogenic', 'Sarcopenia-affect-Pulmonary Disease, Chronic Obstructive', 'Death-complicate-Myocardial Infarction', 'Shock, Cardiogenic-complicate-Myocardial Infarction', 'Anemia-reduce-Death', 'Kidney Diseases-reduce-Death', 'Erectile Dysfunction-associated-Hypertension', 'Hypertension-associated-Erectile Dysfunction', 'Erectile Dysfunction-associated-Chronic Disease', 'Chronic Disease-associated-Erectile Dysfunction', 'Sarcopenia-derived-Death', 'Blister-occur-Sclerosis', 'Neoplasms-used-Prostatic Neoplasms', 'Chest Pain-suspected-Coronary Artery Disease', 'Chest Pain-present-Coronary Artery Disease', 'Brain Injuries, Traumatic-account-Death', 'Death-follow-Myocardial Infarction', 'Brain Injuries, Traumatic-account-Wounds and Injuries', 'Ulcer-known-Peptic Ulcer', 'Death-reduce-Myocardial Infarction', 'Craniocerebral Trauma-transferred-Wounds and Injuries', 'Pneumonia-increasing-Death', 'Birt-Hogg-Dube Syndrome-characterised-Kidney Neoplasms', 'Birt-Hogg-Dube Syndrome-characterised-Lung Diseases', 'Neoplasms-characterised-Kidney Neoplasms', 'Hypoxia-related-Dementia', 'Neoplasms-characterised-Lung Diseases', 'Neoplasms-characterised-Birt-Hogg-Dube Syndrome', 'Alzheimer Disease-reduce-Dehydration', 'Death-related-Brain Injuries, Traumatic', 'Sleep Wake Disorders-associated-Metabolic Syndrome', 'Metabolic Syndrome-associated-Sleep Wake Disorders', 'Skin Neoplasms-include-Neoplasms', 'Salivary Gland Neoplasms-identified-Neoplasms', 'Heart Diseases-potentiated-Hypotension', 'Carcinoma, Non-Small-Cell Lung-receive-Drug-Related Side Effects and Adverse Reactions', 'Obesity-suffer-Hypertension', 'Obesity-suffer-Diabetes Mellitus', 'Obesity-suffer-Neoplasms', 'Diabetes Mellitus-contribute-Death', 'Obesity-suffer-Heart Diseases', 'Obesity-suffer-Stroke', 'Obesity-suffer-Arthritis', 'Hip Fractures-studied-Death', 'Kidney Neoplasms-generate-Kidney Diseases', 'Pyomyositis-become-Epidural Abscess', 'Infections-become-Epidural Abscess', 'Diabetes Mellitus-associated-Parkinson Disease', 'Parkinson Disease-associated-Diabetes Mellitus', 'Polymyalgia Rheumatica-characterized-Pelvic Girdle Pain', 'Polymyalgia Rheumatica-characterized-Pain', 'Inflammation-characterized-Pelvic Girdle Pain', 'Inflammation-characterized-Pain', 'Cross Infection-compare-Hematologic Neoplasms', 'Diabetes Mellitus-show-Coma', 'Cross Infection-cause-Death', 'Cross Infection-cause-Hematologic Neoplasms', 'Stroke, Lacunar-known-Cerebral Small Vessel Diseases', 'Fractures, Bone-judge-Hip Fractures', 'Cross Infection-observed-Hematologic Neoplasms', 'Cross Infection-observed-Leukemia, Myeloid', 'Cross Infection-observed-Lymphoma', 'Heart Arrest-caused-Pneumoperitoneum', 'Myocardial Infarction-include-Stroke', 'Myocardial Infarction-include-Ischemia', 'Myocardial Infarction-include-Hemorrhage', 'Cerebrovascular Disorders-include-Stroke', 'Cerebrovascular Disorders-include-Ischemia', 'Cerebrovascular Disorders-include-Hemorrhage', 'Ankle Injuries-fall-Cardiac Output, Low', 'Hyperglycemia-mediated-Peripheral Nervous System Diseases', 'Diabetes Mellitus-accelerate-Muscular Diseases', 'Neoplasms-underestimated-Death', 'Peptic Ulcer-prevent-Atherosclerosis', 'Sarcopenia-develop-Cardiovascular Diseases', 'Sarcopenia-show-Cardiovascular Diseases', 'Sarcopenia-show-Stroke', 'Obesity-increase-Dementia', 'Aneurysm-increase-Dementia', 'Metabolic Syndrome-increase-Dementia', 'Critical Illness-include-Stroke', 'Critical Illness-meet-Stroke', 'Critical Illness-include-Brain Injuries, Traumatic', 'Critical Illness-meet-Brain Injuries, Traumatic', 'Critical Illness-include-Sepsis', 'Critical Illness-meet-Sepsis', 'Hypertension-receive-Stomach Neoplasms', 'Ulcer-related-Diabetes Mellitus', 'Anemia-associated-Chronic Disease', 'Chronic Disease-associated-Anemia', 'Vision Disorders-assess-Fractures, Bone', 'Bone Neoplasms-prevent-Osteoporosis', 'Bone Neoplasms-minimise-Fractures, Bone', 'Osteoporosis-minimise-Fractures, Bone', 'Vision Disorders-associated-Fractures, Bone', 'Fractures, Bone-associated-Vision Disorders', 'Carcinoma, Squamous Cell-associated-Pneumonia', 'Pneumonia-associated-Carcinoma, Squamous Cell', 'Carcinoma, Squamous Cell-associated-Death', 'Death-associated-Carcinoma, Squamous Cell', 'Vascular System Injuries-predict-Death', 'Hyperlipidemias-identify-Dementia', 'Hyperlipidemias-identify-Alzheimer Disease', 'Inflammation-link-Death', 'Death-associated-Sleep Wake Disorders', 'Sleep Wake Disorders-associated-Death', 'Carcinoma, Squamous Cell-include-Skin Neoplasms', 'Carcinoma, Basal Cell-include-Skin Neoplasms', 'Prostatic Intraepithelial Neoplasia-include-Cutaneous Fistula', 'Obesity-show-Cardiovascular Diseases', 'Obesity-show-Death', 'Hypertension-develop-Hyponatremia', 'Malnutrition-predict-Death', 'Head and Neck Neoplasms-restricted-Death', 'Sleep Wake Disorders-associated-Inflammation', 'Inflammation-associated-Sleep Wake Disorders', 'Sleep Wake Disorders-associated-Communicable Diseases', 'Communicable Diseases-associated-Sleep Wake Disorders', 'Sleep Apnea Syndromes-measure-Sleepiness', 'Sleep Wake Disorders-associated-Sleepiness', 'Sleepiness-associated-Sleep Wake Disorders', 'Sleep Wake Disorders-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-Sleep Wake Disorders', 'Obesity-linked-Death', 'Hip Fractures-diagnosed-Sarcopenia', 'Leukoaraiosis-defined-Atherosclerosis', 'Leukoaraiosis-caused-Atherosclerosis', 'Obesity, Abdominal-considered-Death', 'Arthritis-return-Pain', 'Breast Neoplasms-limited-Neoplasms', 'Voice Disorders-aggravated-Parkinson Disease', 'Drug Hypersensitivity-recruited-Asthma', 'Diabetes Mellitus-predispose-Liver Abscess, Pyogenic', 'Endophthalmitis-associated-Liver Abscess, Pyogenic', 'Liver Abscess, Pyogenic-associated-Endophthalmitis', 'Infections-predispose-Liver Abscess, Pyogenic', 'Dementia-allocated-Death', 'Dementia-improve-Death', 'Death-predict-Wounds and Injuries', 'Inflammation-associated-Kidney Failure, Chronic', 'Kidney Failure, Chronic-associated-Inflammation', 'Sleepiness-compare-Polycystic Ovary Syndrome', 'Sarcopenia-describe-Brain Injuries, Traumatic', 'Sarcopenia-related-Brain Injuries, Traumatic', 'Colorectal Neoplasms-related-Neoplasms', 'Pain-undertreated-Dementia', 'Hypotension-sustain-Fractures, Bone', 'Spinal Stenosis-caused-Hypertrophy', 'Cardiovascular Diseases-initiate-Atherosclerosis', 'Pain-compare-Osteoarthritis, Hip', 'Sialic Acid Storage Disease-identify-Apnea', 'Neurodegenerative Diseases-mark-Leukoencephalopathies', 'Neurodegenerative Diseases-mark-Atrophy', 'Sialic Acid Storage Disease-exhibit-Osteoporosis', 'Inflammation-include-Asthma', 'Airway Obstruction-include-Asthma', 'Diabetes Mellitus-investigated-Leukoencephalopathies', 'Polymyalgia Rheumatica-remain-Arteritis', 'Peutz-Jeghers Syndrome-associated-Neoplasms', 'Neoplasms-associated-Peutz-Jeghers Syndrome', 'Bacteremia-use-Infections', 'Sepsis-determine-Bacteremia', 'Neurodegenerative Diseases-share-Mitochondrial Diseases', 'Gliosis-implicate-Neurodegenerative Diseases', 'Herpes Zoster-treat-Renal Insufficiency, Chronic', 'Delirium-predispose-Dementia', 'Death-observed-Pain', 'Death-use-Dementia', 'Diabetes Mellitus-coincide-Obesity', 'Cerebral Infarction-experience-Brain Injuries, Traumatic', 'Pain-result-Pain Insensitivity, Congenital', 'Carcinoma, Intraductal, Noninfiltrating-account-Breast Neoplasms', 'Inflammation-relate-Chronic Disease', 'Esophageal Neoplasms-develop-Neoplasms', 'Goiter-choke-Dyspnea', 'Goiter-choke-Sleep Apnea Syndromes', 'Goiter-choke-Deglutition Disorders', 'Dyspnea-choke-Sleep Apnea Syndromes', 'Dyspnea-choke-Deglutition Disorders', 'Sleep Apnea Syndromes-choke-Deglutition Disorders', 'Lung Diseases-include-Chronic Disease', 'Chronic Disease-trigger-Atherosclerosis', 'Cardiovascular Diseases-apply-Death', 'Cardiovascular Diseases-apply-Neoplasms', 'Death-apply-Neoplasms', 'Kidney Diseases-associated-Aortic Diseases', 'Aortic Diseases-associated-Kidney Diseases', 'Hemorrhage-receive-Venous Thromboembolism', 'Pneumonia-considered-Death', 'Sepsis-increase-Death', 'Death-undergo-Musculoskeletal Diseases', 'Fever-related-Infections', 'Neoplasms-undergo-Tibial Meniscus Injuries', 'Adrenal Insufficiency-associated-Osteoporotic Fractures', 'Osteoporotic Fractures-associated-Adrenal Insufficiency', 'Pain-increase-Sleep Initiation and Maintenance Disorders', 'Neurologic Manifestations-participate-Somatosensory Disorders', 'Cardiovascular Diseases-remain-Hypertension', 'Cardiovascular Diseases-remain-Metabolic Diseases', 'Cardiovascular Diseases-remain-Dyslipidemias', 'Cardiovascular Diseases-remain-Metabolic Syndrome', 'Metabolic Diseases-known-Metabolic Syndrome', 'Adrenal Insufficiency-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-Adrenal Insufficiency', 'Dyslipidemias-known-Metabolic Syndrome', 'Nervous System Diseases-relate-HIV Infections', 'Nervous System Diseases-relate-Acquired Immunodeficiency Syndrome', 'Arthritis-associated-Vision Disorders', 'Vision Disorders-associated-Arthritis', 'Stroke-associated-Vision Disorders', 'Vision Disorders-associated-Stroke', 'Death-base-Colorectal Neoplasms', 'Ataxia-lead-Death', 'Death-increase-Colorectal Neoplasms', 'Carcinoma, Hepatocellular-related-Hepatitis C', 'Colorectal Neoplasms-identify-Drug-Related Side Effects and Adverse Reactions', 'Hallucinations-associated-REM Sleep Behavior Disorder', 'REM Sleep Behavior Disorder-associated-Hallucinations', 'Hallucinations-associated-Parkinson Disease', 'Parkinson Disease-associated-Hallucinations', 'Polyuria-increase-Dehydration', 'Spinal Stenosis-cause-Pain', 'Polyuria-increase-Drug-Related Side Effects and Adverse Reactions', 'Spinal Stenosis-occur-Spinal Diseases', 'Scoliosis-cause-Pain', 'Scoliosis-occur-Spinal Diseases', 'Lung Diseases-lead-Death', 'Fractures, Bone-distinguish-Musculoskeletal Diseases', 'Head and Neck Neoplasms-assessed-Death', 'Neoplasms-assessed-Death', 'Chronic Disease-include-Cardiovascular Diseases', 'Chronic Disease-include-Diabetes Mellitus, Type 2', 'Chronic Disease-include-Osteoporosis', 'Hip Fractures-decrease-Hypotension', 'Diabetes Mellitus-associate-Aortic Aneurysm, Abdominal', 'Aortic Aneurysm, Abdominal-associate-Diabetes Mellitus', 'Diabetes Mellitus-associate-Aortic Aneurysm, Thoracic', 'Aortic Aneurysm, Thoracic-associate-Diabetes Mellitus', 'Acquired Immunodeficiency Syndrome-associated-Death', 'Death-associated-Acquired Immunodeficiency Syndrome', 'Infarction, Middle Cerebral Artery-reduce-Death', 'Polycystic Ovary Syndrome-represent-Metabolic Diseases', 'Cerebrovascular Disorders-associated-Dementia', 'Dementia-associated-Cerebrovascular Disorders', 'Labyrinth Diseases-lead-Neurologic Manifestations', 'Obesity, Abdominal-associated-Chronic Disease', 'Chronic Disease-associated-Obesity, Abdominal', 'Macular Degeneration-included-Alzheimer Disease', 'Adrenal Insufficiency-associated-Macular Degeneration', 'Macular Degeneration-associated-Adrenal Insufficiency', 'Pneumonia-identify-Death', 'Fractures, Stress-observed-Osteoporotic Fractures', 'Parkinson Disease-present-Hallucinations', 'Gastritis, Atrophic-associated-Osteoporosis', 'Osteoporosis-associated-Gastritis, Atrophic', 'Hyperuricemia-associated-Atrial Fibrillation', 'Atrial Fibrillation-associated-Hyperuricemia', 'Prediabetic State-develop-Diabetes Mellitus', 'Diabetes Mellitus-follow-Hearing Loss', 'Hypertension-hear-Hearing Loss', 'Pancreatic Neoplasms-followed-Colorectal Neoplasms', 'Neoplasms-followed-Colorectal Neoplasms', 'Hepatitis C-play-Carcinogenesis', 'Neurodegenerative Diseases-used-Parkinson Disease', 'Fractures, Bone-incorporate-Osteoporotic Fractures', 'Arrhythmias, Cardiac-increase-Stroke', 'Metabolic Syndrome-associated-Death', 'Death-associated-Metabolic Syndrome', 'Pain-measured-Osteoarthritis', 'Fractures, Bone-comprise-Hip Fractures', 'Inflammation-associated-Sepsis', 'Sepsis-associated-Inflammation', 'Thyroid Diseases-accelerate-Atherosclerosis', 'Drug Hypersensitivity-associated-Syncope', 'Syncope-associated-Drug Hypersensitivity', 'Drug Hypersensitivity-use-Hypotension', 'Metabolic Syndrome-lead-Atherosclerosis', 'Metabolic Syndrome-lead-Diabetes Mellitus', 'Stroke-mimic-Meningitis', 'Stroke-known-Alzheimer Disease', 'Stroke-known-Dementia', 'Alzheimer Disease-known-Dementia', 'Pain-associated-Arthritis', 'Arthritis-associated-Pain', 'Low Back Pain-associated-Arthritis', 'Arthritis-associated-Low Back Pain', 'Musculoskeletal Pain-associated-Arthritis', 'Arthritis-associated-Musculoskeletal Pain', 'Arthritis-associated-Headache', 'Headache-associated-Arthritis', 'Arthritis-associated-Acute Pain', 'Acute Pain-associated-Arthritis', 'Arthritis-associated-Dysmenorrhea', 'Dysmenorrhea-associated-Arthritis', 'Diabetes Mellitus-modify-Death', 'Inflammation-represent-Death', 'Coma-used-Nervous System Diseases', 'Coma-define-Nervous System Diseases', 'Foodborne Diseases-associate-Infections', 'Infections-associate-Foodborne Diseases', 'Coma-used-Brain Injuries, Traumatic', 'Coma-define-Brain Injuries, Traumatic', 'Arthritis-originate-Abnormalities, Drug-Induced', 'Obesity-associated-Sleep Wake Disorders', 'Sleep Wake Disorders-associated-Obesity', 'Atrial Fibrillation-face-Stroke', 'Dementia-pose-Alzheimer Disease', 'Death-certified-Pneumonia', 'Pneumonia-certified-Neoplasms', 'Pneumonia-certified-Ischemia', 'Pneumonia-certified-Heart Diseases', 'Hemorrhage-result-Hemophilia A', 'Parkinson Disease-occur-Inflammation', 'Parkinson Disease-caused-Respiratory Tract Infections', 'Parkinson Disease-caused-Pneumonia', 'Parkinson Disease-result-Delirium', 'Inflammation-caused-Respiratory Tract Infections', 'Inflammation-caused-Pneumonia', 'Inflammation-result-Delirium', 'Respiratory Tract Infections-result-Delirium', 'Pneumonia-result-Delirium', 'Acidosis, Lactic-thought-Ischemia', 'Prostatic Neoplasms-represent-Neoplasms', 'Cardiovascular Diseases-result-Death', 'Muscular Diseases-associated-Inflammation', 'Inflammation-associated-Muscular Diseases', 'Cardiac Output, Low-experienced-Parkinson Disease', 'Hypothyroidism-compare-Euthyroid Sick Syndromes', 'Hypothyroidism-found-Euthyroid Sick Syndromes', 'Hip Fractures-compare-Euthyroid Sick Syndromes', 'Hip Fractures-found-Euthyroid Sick Syndromes', 'Muscular Atrophy-link-Inflammation', 'Neoplasms-link-Inflammation', 'Acquired Immunodeficiency Syndrome-link-Inflammation', 'Chronic Disease-link-Inflammation', 'Asthma-associate-Rhinitis', 'Rhinitis-associate-Asthma', 'Acidosis, Lactic-influence-Critical Illness', 'Chronic Disease-influence-Diabetes Mellitus', 'Aneurysm-develop-Diabetes Mellitus', 'Death-remain-Gastrointestinal Diseases', 'Gastrointestinal Diseases-remain-HIV Infections', 'Neoplasms-account-Breast Neoplasms', 'Neoplasms-account-Death', 'Osteoporosis-remain-HIV Infections', 'Osteoporosis-remain-Death', 'Wounds and Injuries-used-Death', 'Wounds and Injuries-evaluate-Death', 'Wounds and Injuries-used-Fractures, Bone', 'Wounds and Injuries-present-Fractures, Bone', 'Death-present-Fractures, Bone', 'Fibromyalgia-understudied-Pain', 'Death-suffer-Pain', 'Hypertension-associate-Diabetes Mellitus', 'Diabetes Mellitus-associate-Hypertension', 'Hypertension-associate-Hypercholesterolemia', 'Hypercholesterolemia-associate-Hypertension', 'Vision Disorders-increased-Glaucoma', 'Mitochondrial Diseases-linked-Neurodegenerative Diseases', 'Fibrosis-underlie-Hepatitis, Viral, Human', 'Fibrosis-underlie-Alcoholism', 'Fibrosis-contribute-Liver Diseases', 'Hepatitis, Viral, Human-contribute-Liver Diseases', 'Liver Diseases-attributed-Coinfection', 'Alcoholism-contribute-Liver Diseases', 'Death-attributed-Coinfection', 'Hip Fractures-associated-Craniocerebral Trauma', 'Craniocerebral Trauma-associated-Hip Fractures', 'Nocturnal Enuresis-associated-Nocturia', 'Nocturia-associated-Nocturnal Enuresis', 'Heart Diseases-increase-Alzheimer Disease', 'Alzheimer Disease-related-Atrial Fibrillation', 'Inflammation-caused-HIV Infections', 'Lipodystrophy-caused-HIV Infections', 'Chronic Pain-consist-Musculoskeletal Pain', 'Chronic Pain-consist-Pain', 'Pain-consist-Musculoskeletal Pain', 'Stroke-concern-Atrial Fibrillation', 'Hypertension-followed-Coronary Artery Disease', 'Hypertension-followed-Arrhythmias, Cardiac', 'Fractures, Bone-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-Fractures, Bone', 'Pulmonary Disease, Chronic Obstructive-coexist-Carcinoma, Non-Small-Cell Lung', 'Synovitis-associated-Fractures, Bone', 'Fractures, Bone-associated-Synovitis', 'Synovitis-compare-Fractures, Bone', 'Hypertension-include-Myocardial Infarction', 'Hypertension-aged-Myocardial Infarction', 'Hypertension-aged-Atrial Fibrillation', 'Hypertension-include-Diabetes Mellitus', 'Hypertension-aged-Diabetes Mellitus', 'Hypertension-include-Kidney Diseases', 'Hypertension-aged-Kidney Diseases', 'Hypogonadism-consult-Sexual Dysfunction, Physiological', 'Nocturia-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-Nocturia', 'Nocturia-associated-Hypertension', 'Hypertension-associated-Nocturia', 'Nocturia-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-Nocturia', 'Progeria-result-Stroke', 'Obesity-appear-Neoplasms', 'Neurodegenerative Diseases-associated-Epilepsy', 'Epilepsy-associated-Neurodegenerative Diseases', 'Uterine Inertia-implement-Chronic Disease', 'Uterine Inertia-implement-Arthritis, Rheumatoid', 'Dementia-referred-Alzheimer Disease', 'Dementia-screened-Alzheimer Disease', 'Death-use-Chronic Disease', 'Parkinson Disease, Secondary-include-Basal Ganglia Diseases', 'Critical Illness-treat-Infections', 'Fibromyalgia-exhibit-Demyelinating Diseases', 'Fibromyalgia-exhibit-Guillain-Barre Syndrome', 'Respiratory Tract Diseases-monitored-Infections', 'Diabetes Mellitus-monitored-Infections', 'Parkinson Disease-associated-Fractures, Bone', 'Fractures, Bone-associated-Parkinson Disease', 'Pneumonia-include-Infections', 'Liver Abscess, Pyogenic-associated-Colonic Diseases', 'Colonic Diseases-associated-Liver Abscess, Pyogenic', 'Hypogonadism-cause-Erectile Dysfunction', 'Hypogonadism-cause-Obesity, Abdominal', 'Erectile Dysfunction-reduce-Obesity', 'Erectile Dysfunction-improve-Metabolic Syndrome', 'Obesity-improve-Metabolic Syndrome', 'Osteoporosis-lead-Osteoporotic Fractures', 'Osteoporosis-lead-Back Pain', 'Osteoporotic Fractures-cause-Back Pain', 'Diabetes Mellitus-associated-Neoplasms', 'Neoplasms-associated-Diabetes Mellitus', 'Periodontitis-associated-Inflammation', 'Inflammation-associated-Periodontitis', 'Obesity-experience-Weight Loss', 'Diabetes Mellitus, Type 2-undergo-Fatty Liver', 'Parkinsonian Disorders-associated-Aneurysm', 'Aneurysm-associated-Parkinsonian Disorders', 'Parkinsonian Disorders-associated-Dementia', 'Dementia-associated-Parkinsonian Disorders', 'Mucopolysaccharidosis III-associated-Aneurysm', 'Aneurysm-associated-Mucopolysaccharidosis III', 'Mucopolysaccharidosis III-associated-Dementia', 'Dementia-associated-Mucopolysaccharidosis III', 'Dementia-associated-Parkinson Disease', 'Parkinson Disease-associated-Dementia', 'Critical Illness-develop-Kidney Diseases', 'Lung Injury-lead-Pulmonary Edema', 'Lung Injury-lead-Respiratory Insufficiency', 'Brain Neoplasms-associated-Wounds and Injuries', 'Wounds and Injuries-associated-Brain Neoplasms', 'Kidney Diseases-assess-Albuminuria', 'Brain Neoplasms-associated-Hypertension', 'Hypertension-associated-Brain Neoplasms', 'Heart Failure-assess-Albuminuria', 'Diabetes Mellitus-enhance-Glucose Metabolism Disorders', 'Diabetes Mellitus-enhance-Alzheimer Disease', 'Hyponatremia-found-Hypernatremia', 'Prostatic Neoplasms-associated-Drug-Related Side Effects and Adverse Reactions', 'Drug-Related Side Effects and Adverse Reactions-associated-Prostatic Neoplasms', 'Infections-worsen-Stroke', 'Leukoencephalopathies-increase-Heart Failure, Diastolic', 'Infections-exacerbated-Brain Injuries', 'Infections-exacerbated-Atherosclerosis', 'Brain Injuries-exacerbated-Atherosclerosis', 'Tachycardia, Ventricular-associated-Death', 'Death-associated-Tachycardia, Ventricular', 'Ventricular Fibrillation-associated-Death', 'Death-associated-Ventricular Fibrillation', 'Death-compare-Osteoporotic Fractures', 'Sarcopenia-accelerate-Frailty', 'Atherosclerosis-exacerbate-Brain Injuries', 'Atherosclerosis-augment-Inflammation', 'Brain Injuries-augment-Inflammation', 'Femoral Neck Fractures-comprise-Wounds and Injuries', 'Diabetes Mellitus-observed-Hypercholesterolemia', 'Psoriasis-associated-Erectile Dysfunction', 'Erectile Dysfunction-associated-Psoriasis', 'Diabetes Mellitus-observed-Hypertension', 'Diabetes Mellitus-observed-Renal Insufficiency', 'Arthritis-followed-Diabetes Mellitus', 'Arthritis-followed-Asthma', 'Skin Diseases-associated-Erectile Dysfunction', 'Erectile Dysfunction-associated-Skin Diseases', 'Arthritis-followed-Coronary Artery Disease', 'Metabolic Syndrome-demonstrated-Neoplasms', 'Metabolic Syndrome-diagnosed-Stomach Neoplasms', 'Metabolic Syndrome-associated-Neoplasms', 'Neoplasms-associated-Metabolic Syndrome', 'Metabolic Syndrome-associated-Stomach Neoplasms', 'Stomach Neoplasms-associated-Metabolic Syndrome', 'Obesity, Abdominal-associated-Hip Fractures', 'Hip Fractures-associated-Obesity, Abdominal', 'Osteoarthritis-influenced-Arthralgia', 'Head and Neck Neoplasms-associated-Death', 'Death-associated-Head and Neck Neoplasms', 'Hypotension-associated-Peripheral Arterial Disease', 'Peripheral Arterial Disease-associated-Hypotension', 'Metabolic Syndrome-associated-Hyperglycemia', 'Hyperglycemia-associated-Metabolic Syndrome', 'Metabolic Syndrome-drive-Hyperglycemia', 'Cytomegalovirus Infections-decrease-HIV Infections', 'Heart Failure-assess-Aneurysm', 'Heart Failure-assess-Cerebrovascular Disorders', 'Dyslipidemias-associated-HIV Infections', 'HIV Infections-associated-Dyslipidemias', 'Dyslipidemias-increase-Atherosclerosis', 'Alzheimer Disease-recruited-Psychoses, Substance-Induced', 'Alzheimer Disease-recruited-Psychomotor Agitation', 'Heart Failure-develop-Aneurysm', 'Hypercholesterolemia-include-Obesity', 'Wounds and Injuries-receive-Death', 'Death-decrease-Myocardial Infarction', 'Dystonia-associated-Essential Tremor', 'Essential Tremor-associated-Dystonia', 'Atrial Fibrillation-estimated-Hip Fractures', 'Infections-related-Malnutrition', 'Pneumonia-associated-Meningeal Neoplasms', 'Meningeal Neoplasms-associated-Pneumonia', 'Heart Failure-increase-Death', 'Erectile Dysfunction-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-Erectile Dysfunction', 'Aneurysm-contribute-Muscle Weakness', 'Enterocolitis, Pseudomembranous-include-Neoplasms', 'Neoplasms-diagnosed-Pancreatic Neoplasms', 'Eunuchism-associated-Death', 'Death-associated-Eunuchism', 'Neoplasms-underlie-Enterocolitis, Pseudomembranous', 'Sleep Wake Disorders-associated-Sleep Initiation and Maintenance Disorders', 'Sleep Initiation and Maintenance Disorders-associated-Sleep Wake Disorders', 'Hypoxia-associated-Sleep Initiation and Maintenance Disorders', 'Sleep Initiation and Maintenance Disorders-associated-Hypoxia', 'Uremia-contribute-Death', 'Kidney Failure, Chronic-used-Diabetes Mellitus', 'Aneurysm-related-Hypertension', 'Sleep Wake Disorders-associated-Hypoxia', 'Hypoxia-associated-Sleep Wake Disorders', 'Renal Insufficiency-correspond-Inflammation', 'Pneumonia-represent-Infections', 'Pneumonia-represent-Death', 'Hypertension-reported-Leukoaraiosis', 'Dementia-include-Stroke', 'Dementia-validate-Chediak-Higashi Syndrome', 'Dementia-validate-Myoclonic Epilepsies, Progressive', 'Delirium-distress-Dementia', 'Hypoalbuminemia-associated-Death', 'Death-associated-Hypoalbuminemia', 'Hypoalbuminemia-associated-Critical Illness', 'Critical Illness-associated-Hypoalbuminemia', 'Quadriplegia-provide-Spinal Cord Injuries', 'Nervous System Diseases-predict-Death', 'Bone Neoplasms-increase-Fractures, Bone', 'Metabolic Syndrome-initiate-Atherosclerosis', 'Drug-Related Side Effects and Adverse Reactions-used-Lung Neoplasms', 'Hyperhomocysteinemia-associated-Leukoencephalopathies', 'Leukoencephalopathies-associated-Hyperhomocysteinemia', 'Hyperhomocysteinemia-associated-Stroke, Lacunar', 'Stroke, Lacunar-associated-Hyperhomocysteinemia', 'Metabolic Diseases-consider-Hyperlipidemias', 'Hyperlipidemias-consider-Peripheral Nervous System Diseases', 'Carcinoma, Squamous Cell-cause-Drug-Related Side Effects and Adverse Reactions', 'Hyperlipidemias-precede-Peripheral Nervous System Diseases', 'Fractures, Bone-use-Coxa Magna', 'Hyperalgesia-result-Wounds and Injuries', 'Hip Fractures-sustain-Spinal Injuries', 'Renal Insufficiency, Chronic-characterized-Myopathies, Structural, Congenital', 'Memory Disorders-identify-Alzheimer Disease', 'Occupational Stress-seen-Vision Disorders', 'Thalassemia-exposed-Communicable Diseases', 'Vascular Calcification-demonstrate-Renal Insufficiency, Chronic', 'Seizures-reflect-Dementia', 'Seizures-increase-Dementia', 'Infections-recorded-Pneumonia', 'Infections-recorded-Respiratory Tract Infections', 'Infections-recorded-Arthritis, Infectious', 'Kidney Diseases-contribute-Diabetes Mellitus', 'Kidney Diseases-contribute-Hypertension', 'Heart Failure, Diastolic-observed-Heart Diseases', 'Diabetes Mellitus-deserve-Carcinoma, Hepatocellular', 'Death-limit-Pain', 'Diabetes Mellitus-reduce-Death', 'Hypogonadism-defined-Death', 'Muscle Weakness-associated-Fatigue', 'Fatigue-associated-Muscle Weakness', 'Kidney Failure, Chronic-preceded-Death', 'Amyloidosis-increased-Neoplasms', 'Craniocerebral Trauma-associated-Dementia', 'Dementia-associated-Craniocerebral Trauma', 'Amyloidosis-increased-Multiple Myeloma', 'Tuberculosis-develop-Acute Kidney Injury', 'Amyloidosis-increased-Lymphoma, Non-Hodgkin', 'Amyloidosis-increased-Carcinoma, Squamous Cell', 'Cardiovascular Diseases-lead-Cardiomyopathies', 'Dementia-identify-Pain', 'Dementia-define-Pain', 'Death-result-Subarachnoid Hemorrhage', 'Neoplasms-receive-Ureteral Obstruction', 'Death-ascribed-Tuberculosis', 'Craniocerebral Trauma-associated-Alzheimer Disease', 'Alzheimer Disease-associated-Craniocerebral Trauma', 'Wounds and Injuries-associated-Neurodegenerative Diseases', 'Neurodegenerative Diseases-associated-Wounds and Injuries', 'Pneumococcal Infections-associated-Endocarditis', 'Endocarditis-associated-Pneumococcal Infections', 'Pneumococcal Infections-associated-Colorectal Neoplasms', 'Colorectal Neoplasms-associated-Pneumococcal Infections', 'Pneumonia-associated-Dementia', 'Dementia-associated-Pneumonia', 'Diabetes Mellitus-become-Kidney Failure, Chronic', 'Myotonic Dystrophy-become-Kidney Failure, Chronic', 'Renal Insufficiency, Chronic-become-Kidney Failure, Chronic', 'Diabetic Nephropathies-become-Kidney Failure, Chronic', 'Pneumococcal Infections-associated-Colonic Neoplasms', 'Colonic Neoplasms-associated-Pneumococcal Infections', 'Delirium-constitute-Hip Fractures', 'Delirium-constitute-Fractures, Bone', 'Fractures, Bone-remain-Heart Failure', 'Appendicitis-progress-Inflammation', 'Appendicitis-progress-Necrosis', 'Inflammation-progress-Necrosis', 'Dementia-account-Alzheimer Disease', 'Memory Disorders-include-Dementia', 'Psychomotor Agitation-include-Dementia', 'Fibrosis-implicated-Heart Failure', 'Fibrosis-predict-Death', 'Inflammation-implicated-Heart Failure', 'Heart Failure-predict-Death', 'Neoplasms-related-Colorectal Neoplasms', 'Diabetes Mellitus-influence-Glucose Metabolism Disorders', 'Parkinson Disease-detect-Neurodegenerative Diseases', 'Memory Disorders-detect-Parkinson Disease', 'Constipation-detect-Parkinson Disease', 'Hypotension, Orthostatic-detect-Parkinson Disease', 'REM Sleep Behavior Disorder-detect-Parkinson Disease', 'Diabetes Mellitus-followed-Hypoglycemia', 'Memory Disorders-appear-Parkinson Disease', 'Neuromyelitis Optica-defined-Myelitis', 'Heart Failure-appear-Parkinson Disease', 'Cardiovascular Diseases-followed-Hypoglycemia', 'Myelitis-defined-Neuromyelitis Optica', 'Constipation-appear-Parkinson Disease', 'Hypotension-appear-Parkinson Disease', 'Sleep Wake Disorders-appear-Parkinson Disease', 'REM Sleep Behavior Disorder-appear-Parkinson Disease', 'Pruritus-cause-Pain', 'Olfaction Disorders-appear-Parkinson Disease', 'Kidney Calculi-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-Kidney Calculi', 'Kidney Calculi-associated-Stroke', 'Stroke-associated-Kidney Calculi', 'Peripheral Arterial Disease-associated-Mesenteric Vascular Occlusion', 'Mesenteric Vascular Occlusion-associated-Peripheral Arterial Disease', 'Glucose Metabolism Disorders-decrease-Alzheimer Disease', 'HIV Infections-accelerate-Liver Diseases', 'Liver Diseases-accelerate-Hepatitis C', 'Chemical and Drug Induced Liver Injury-examined-Liver Failure', 'Prostatic Neoplasms-lead-Respiratory Distress Syndrome', 'Acquired Immunodeficiency Syndrome-live-Death', 'Chronic Disease-classified-Polyps', 'Hematoma, Subdural, Chronic-evaluate-Coma', 'Fractures, Bone-complicated-Femur Head Necrosis', 'Upper Extremity Deep Vein Thrombosis-affect-Breast Neoplasms', 'Breast Neoplasms-represent-Death', 'Coronary Artery Disease-cause-Death', 'Mucopolysaccharidosis III-indicate-Atherosclerosis', 'Mucopolysaccharidosis III-indicate-Coronary Artery Disease', 'Osteoporosis-considered-Bone Diseases', 'Osteoporosis-considered-Fractures, Bone', 'Fractures, Bone-viewed-Bone Diseases', 'Endometrial Neoplasms-rise-Obesity', 'Arthritis-involved-Acute Pain', 'Chronic Disease-represent-Sleep Wake Disorders', 'Dyspnea-measured-Death', 'Wounds and Injuries-account-Death', 'Wounds and Injuries-account-HIV Infections', 'Wounds and Injuries-help-Malaria', 'Death-include-Chronic Disease', 'Neurodegenerative Diseases-mediate-Diabetes Mellitus', 'Skin Diseases-estimate-Death', 'Skin Diseases-underlie-Death', 'Skin Diseases-used-Death', 'Hypertension-demonstrate-Cardiac Output, Low', 'Obesity-predict-Death', 'Cardiovascular Diseases-occur-Stroke', 'Heart Failure-occur-Stroke', 'Pain-assess-Osteoarthritis', 'Chemical and Drug Induced Liver Injury-associate-Heart Failure', 'Heart Failure-associate-Chemical and Drug Induced Liver Injury', 'Aneurysm-associate-Heart Failure', 'Heart Failure-associate-Aneurysm', 'Sleep Apnea Syndromes-related-Stroke', 'Sleep Apnea Syndromes-related-Cardiovascular Diseases', 'Atrial Fibrillation-occur-Obesity', 'Adrenal Insufficiency-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-Adrenal Insufficiency', 'Breast Neoplasms-account-Death', 'Death-undergo-Aortic Aneurysm', 'Cytomegalovirus Infections-associated-Death', 'Death-associated-Cytomegalovirus Infections', 'Sleep Wake Disorders-improve-Dementia', 'Hypotension, Orthostatic-accompanied-Headache', 'Hypotension, Orthostatic-fall-Cardiac Output, Low', 'Femoral Neck Fractures-suggest-Death', 'Alzheimer Disease-initiate-Neurodegenerative Diseases', 'Hereditary Breast and Ovarian Cancer Syndrome-show-Renal Insufficiency, Chronic', 'Coronary Artery Disease-target-Pulmonary Disease, Chronic Obstructive', 'Delirium-increase-Alzheimer Disease', 'Respiratory Distress Syndrome-associated-Drug-Related Side Effects and Adverse Reactions', 'Drug-Related Side Effects and Adverse Reactions-associated-Respiratory Distress Syndrome', 'Constipation-associated-Drug-Related Side Effects and Adverse Reactions', 'Drug-Related Side Effects and Adverse Reactions-associated-Constipation', 'Optic Nerve Glioma-include-Brain Neoplasms', 'Hypotension, Orthostatic-associated-Aneurysm', 'Aneurysm-associated-Hypotension, Orthostatic', 'Aortic Aneurysm, Abdominal-lead-Death', 'Neurodegenerative Diseases-lead-Death', 'Atherosclerosis-associated-Psychomotor Disorders', 'Psychomotor Disorders-associated-Atherosclerosis', 'Stroke-implicate-Diabetes Mellitus', 'Carcinoma, Hepatocellular-include-Liver Cirrhosis', 'Carcinoma, Hepatocellular-include-Tremor', 'Death-show-Dementia', 'Corneal Diseases-related-Anisometropia', 'Coronary Artery Disease-understand-Chest Pain', 'Osteoporosis-estimated-Fractures, Bone', 'Osteoporosis-estimated-Hip Fractures', 'Obesity-associated-Thromboembolism', 'Thromboembolism-associated-Obesity', 'Stroke-associated-Weight Loss', 'Weight Loss-associated-Stroke', 'Stroke-associated-Thromboembolism', 'Thromboembolism-associated-Stroke', 'Weight Loss-associated-Thromboembolism', 'Thromboembolism-associated-Weight Loss', 'Dementia-increase-Memory Disorders', 'Neurodegenerative Diseases-predispose-Delirium', 'Headache Disorders, Secondary-reduce-Death', 'Sarcopenia-related-Cardiac Output, Low', 'Aortic Aneurysm, Abdominal-show-Death', 'Carcinoma, Hepatocellular-derived-Liver Failure', 'Aortic Aneurysm, Abdominal-undergo-Aneurysm', 'Sarcopenia-examine-Cardiac Output, Low', 'Pneumonia-present-Respiratory Tract Infections', 'Fractures, Compression-conditioned-Osteoporosis', 'Dyslipidemias-include-Cardiovascular Diseases', 'Thrombosis-include-Cardiovascular Diseases', 'Arrhythmias, Cardiac-include-Cardiovascular Diseases', 'Immunologic Deficiency Syndromes-increase-Glaucoma', 'Diabetes Mellitus-associated-Ventricular Dysfunction', 'Ventricular Dysfunction-associated-Diabetes Mellitus', 'Atherosclerosis-related-Hypertension, Renovascular', 'Atherosclerosis-mediated-Cardiovascular Diseases', 'Joint Diseases-sustain-Fractures, Bone', 'Fractures, Bone-sustain-Osteoporotic Fractures', 'Cerebral Infarction-present-Atrial Fibrillation', 'Ischemia-present-Atrial Fibrillation', 'Albuminuria-serve-Microvascular Angina', 'Albuminuria-associated-Atherosclerosis', 'Atherosclerosis-associated-Albuminuria', 'Albuminuria-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-Albuminuria', 'Microvascular Angina-associated-Atherosclerosis', 'Atherosclerosis-associated-Microvascular Angina', 'Microvascular Angina-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-Microvascular Angina', 'Atrophy-regarded-Neurodegenerative Diseases', 'Atrophy-regarded-Alzheimer Disease', 'Diabetes Mellitus-associated-Urinary Incontinence', 'Urinary Incontinence-associated-Diabetes Mellitus', 'Arthritis-result-Kyphosis', 'Intervertebral Disc Degeneration-result-Kyphosis', 'Bone Diseases-result-Kyphosis', 'Nervous System Diseases-associated-Death', 'Death-associated-Nervous System Diseases', 'Fractures, Bone-occur-Osteoporotic Fractures', 'Osteoporosis-reached-Fractures, Bone', 'Death-follow-Meningeal Neoplasms', 'Death-reflect-Meningeal Neoplasms', 'Pectus Carinatum-increase-Scoliosis', 'Rib Fractures-result-Pain', 'Sleep Wake Disorders-precede-Alzheimer Disease', 'Gastric Outlet Obstruction-impacted-Gallstones', 'Gastric Outlet Obstruction-impacted-Fistula', 'Endophthalmitis-result-Vision Disorders', 'Cataract-result-Vision Disorders', 'Rib Fractures-associated-Death', 'Death-associated-Rib Fractures', 'Status Epilepticus-associated-Epilepsy', 'Epilepsy-associated-Status Epilepticus', 'Leukemoid Reaction-carry-Sepsis', 'Lung Diseases-associated-Hypogonadism', 'Hypogonadism-associated-Lung Diseases', 'Lung Diseases-known-Hypogonadism', 'Renal Insufficiency, Chronic-increase-Anemia', 'Fatigue-associated-Death', 'Death-associated-Fatigue', 'Hypertension-assess-Stroke', 'Hypertension-assess-Kidney Diseases', 'Thalamic Diseases-associated-Thrombosis', 'Thrombosis-associated-Thalamic Diseases', 'Sleep Apnea, Obstructive-exhibit-Kidney Diseases', 'Sleep Apnea Syndromes-characterized-Kidney Diseases', 'Pain-continue-Neoplasms', 'Delirium-prolong-Dementia', 'Death-report-Neoplasms', 'Delirium-undergo-Dementia', 'Colorectal Neoplasms-follow-Lung Neoplasms', 'Diabetes Mellitus-associated-Communicable Diseases', 'Communicable Diseases-associated-Diabetes Mellitus', 'Hip Fractures-decrease-Death', 'Fractures, Bone-decrease-Death', 'Infarction-associated-Periodontal Diseases', 'Periodontal Diseases-associated-Infarction', 'Death-include-Respiratory Insufficiency', 'Signs and Symptoms, Respiratory-include-Respiratory Insufficiency', 'Memory Disorders-seen-Alzheimer Disease', 'Stroke-develop-Alzheimer Disease', 'Sialic Acid Storage Disease-associated-Death', 'Death-associated-Sialic Acid Storage Disease', 'Sick Sinus Syndrome-increase-Atrial Fibrillation', 'Alzheimer Disease-associated-Osteoporosis', 'Osteoporosis-associated-Alzheimer Disease', 'Stroke-associated-Osteoporosis', 'Osteoporosis-associated-Stroke', 'INS-associated-Dementia', 'Dementia-associated-INS', 'Cystic Fibrosis-relate-Respiratory Insufficiency', 'Pulmonary Disease, Chronic Obstructive-impact-Death', 'Infections-occur-Stroke', 'Parkinson Disease-lead-Central Nervous System Diseases', 'Hyperkinesis-refer-Cardiac Output, High', 'Neurotoxicity Syndromes-influence-Alzheimer Disease', 'Ovarian Neoplasms-removed-Endometrial Neoplasms', 'Hypertension-seen-Cardiomyopathy, Dilated', 'Cardiomyopathy, Hypertrophic-seen-Cardiomyopathy, Dilated', 'Airway Obstruction-seen-Cardiomyopathy, Dilated', 'Dementia-investigate-Death', 'Neurologic Manifestations-compare-Osteoporotic Fractures', 'Neurologic Manifestations-treat-Osteoporotic Fractures', 'Infections-enter-Inflammation', 'Infections-cause-Nerve Degeneration', 'Dehydration-diagnose-Stroke', 'Diabetic Nephropathies-observed-Diabetes Mellitus', 'Diabetic Nephropathies-observed-Albuminuria', 'Dehydration-detect-Stroke', 'Epilepsy-associated-Alzheimer Disease', 'Alzheimer Disease-associated-Epilepsy', 'Chronic Urticaria-characterized-Angioedema', 'Drug Hypersensitivity-collect-Urticaria', 'Multiple Myeloma-based-Kidney Diseases', 'Prostatic Neoplasms-suited-Chronic Disease', 'Alzheimer Disease-contribute-Dementia', 'Atherosclerosis-contribute-Dementia', 'Malnutrition-treat-Dementia', 'Arteriosclerosis Obliterans-include-Aneurysm', 'Respiratory Tract Infections-followed-Communicable Diseases', 'Communicable Diseases-followed-Urinary Bladder Diseases', 'Communicable Diseases-followed-Respiratory Tract Infections', 'Communicable Diseases-followed-Infections', 'Glaucoma-lead-Vision Disorders', 'Optic Nerve Diseases-lead-Vision Disorders', 'Osteoarthritis, Hip-play-Pain', 'Osteonecrosis-lead-Osteoarthritis', 'Pain-lead-Osteoarthritis', 'Hypotension-noted-Renal Insufficiency, Chronic', 'Death-occur-Arrhythmias, Cardiac', 'Renal Insufficiency, Chronic-occur-Arrhythmias, Cardiac', 'Neoplasm Metastasis-detected-Musculoskeletal Diseases', 'Cardiomyopathy, Hypertrophic-undergo-Airway Obstruction', 'Cardiomyopathy, Hypertrophic-undergo-Atrial Fibrillation', 'Seizures-exclude-Wounds and Injuries', 'Renal Insufficiency, Chronic-associated-Heart Failure', 'Heart Failure-associated-Renal Insufficiency, Chronic', 'Heredodegenerative Disorders, Nervous System-exclude-Wounds and Injuries', 'Myotonic Dystrophy-seem-Hypoglycemia', 'Myotonic Dystrophy-seem-Dementia', 'Liver Diseases-followed-Hypertension', 'Hepatitis B-followed-Hypertension', 'Hypoglycemia-occur-Diabetes Mellitus', 'Hypoglycemia-occur-Myotonic Dystrophy', 'Neurodegenerative Diseases-associated-Mitochondrial Diseases', 'Mitochondrial Diseases-associated-Neurodegenerative Diseases', 'Liver Failure-treat-Mycoses', 'Liver Failure-treat-Onychomycosis', 'Cardiovascular Diseases-decrease-Hypercholesterolemia', 'Memory Disorders-included-Gait Disorders, Neurologic', 'Melanoma-seen-Pigmentation Disorders', 'Inflammation-link-Hearing Loss', 'Sarcoma, Kaposi-increase-Neoplasms', 'Lymphoma-increase-Neoplasms', 'Diabetes Mellitus-associated-Hepatic Encephalopathy', 'Hepatic Encephalopathy-associated-Diabetes Mellitus', 'Urinary Retention-cause-Urinary Bladder Diseases', 'Infections-prevent-Kidney Calculi', 'Colorectal Neoplasms-rank-Death', 'Sarcopenia-decrease-Inflammation', 'Death-rank-Neoplasms', 'Stroke, Lacunar-considered-Cerebral Small Vessel Diseases', 'Leukoencephalopathies-considered-Cerebral Small Vessel Diseases', 'Hypertension-contribute-Hyperparathyroidism', 'Neurodegenerative Diseases-predict-Death', 'Neoplasm Invasiveness-remain-Death', 'Necrosis-include-Inflammation', 'Carcinoma, Hepatocellular-diagnose-Liver Diseases', 'Weight Loss-treat-Obesity', 'Burkitt Lymphoma-develop-Pneumonia', 'Fractures, Bone-compared-Wounds and Injuries', 'Kidney Diseases-follow-Glomerulonephritis', 'Delirium-treat-Psychomotor Agitation', 'Hernia-engulfed-Edema', 'Migraine without Aura-assessed-Hypertension', 'Migraine without Aura-suffer-Hypertension', 'Migraine without Aura-assessed-Diabetes Mellitus', 'Migraine without Aura-suffer-Diabetes Mellitus', 'Migraine without Aura-assessed-Cardiovascular Diseases', 'Migraine without Aura-suffer-Cardiovascular Diseases', 'Nerve Degeneration-categorized-Alzheimer Disease', 'Thyroid Diseases-associated-Death', 'Death-associated-Thyroid Diseases', 'Cardiovascular Diseases-result-Calcinosis', 'Myelodysplastic Syndromes-measured-Urinary Incontinence', 'Communicable Diseases-study-Cerebral Small Vessel Diseases', 'Delirium-include-Dementia', 'Glucose Metabolism Disorders-compare-Alzheimer Disease', 'Death-compared-Nervous System Diseases', 'Death-compared-Alzheimer Disease', 'Death-rose-Nervous System Diseases', 'Death-rose-Alzheimer Disease', 'Pain-associated-Intervertebral Disc Degeneration', 'Intervertebral Disc Degeneration-associated-Pain', 'Dementia-suffer-Alzheimer Disease', 'Aortic Arch Syndromes-associated-Intracranial Embolism', 'Intracranial Embolism-associated-Aortic Arch Syndromes', 'Infarction-associated-Intracranial Embolism', 'Intracranial Embolism-associated-Infarction', 'Atrial Fibrillation-associated-Inflammation', 'Inflammation-associated-Atrial Fibrillation', 'Prostatic Neoplasms-report-Urinary Incontinence', 'Peripheral Arterial Disease-contribute-Cardiomyopathy, Hypertrophic', 'Hypotension-occur-Takotsubo Cardiomyopathy', 'Shock-occur-Takotsubo Cardiomyopathy', 'Urinary Incontinence-compare-Prostatic Neoplasms', 'Death-interact-Alzheimer Disease', 'Wounds and Injuries-reduce-Death', 'Renal Insufficiency, Chronic-investigate-Death', 'Aortic Valve Stenosis-lead-Dyspnea', 'Aortic Valve Stenosis-lead-Syncope', 'Psychoses, Substance-Induced-define-Alzheimer Disease', 'Psychoses, Substance-Induced-define-Death', 'Werner Syndrome-associated-Neoplasms', 'Neoplasms-associated-Werner Syndrome', 'Alzheimer Disease-define-Death', 'Genetic Diseases, Inborn-associated-Neoplasms', 'Neoplasms-associated-Genetic Diseases, Inborn', 'Asthma-associated-Dementia', 'Dementia-associated-Asthma', 'Urinary Incontinence, Stress-include-Urinary Incontinence', 'Stroke-relate-Alzheimer Disease', 'Dementia-represent-Heart Diseases', 'Pain-include-Cancer Pain', 'Dementia-represent-Neoplasms', 'Kidney Diseases-correlated-Airway Obstruction', 'Kidney Diseases-correlated-Inflammation', 'Pulmonary Disease, Chronic Obstructive-correlated-Airway Obstruction', 'Pulmonary Disease, Chronic Obstructive-correlated-Inflammation', 'Heart Diseases-related-Takotsubo Cardiomyopathy', 'Hip Fractures-followed-Death', 'Fractures, Bone-recommended-Death, Sudden', 'Fractures, Bone-prevent-Death, Sudden', 'Fractures, Bone-recommended-Spinal Cord Diseases', 'Fractures, Bone-prevent-Spinal Cord Diseases', 'Death-associated-Inflammatory Bowel Diseases', 'Inflammatory Bowel Diseases-associated-Death', 'Colorectal Neoplasms-increase-Death', 'Death-came-Neoplasms', 'Cardiovascular Diseases-thought-Death', 'Neoplasms-suffer-Job Syndrome', 'Neoplasms-suffer-Fatigue', 'Metabolic Syndrome-contain-Cardiovascular Diseases', 'Metabolic Syndrome-contain-Diabetes Mellitus', 'Hepatitis B-cause-Kidney Diseases', 'Kidney Diseases-associated-Hypophosphatemia', 'Hypophosphatemia-associated-Kidney Diseases', 'Fanconi Anemia-associated-Hypophosphatemia', 'Hypophosphatemia-associated-Fanconi Anemia', 'Kidney Diseases-develop-Hypophosphatemia', 'Adrenal Insufficiency-characterized-Esotropia', 'Diabetes Mellitus-linked-Death', 'Infections-infect-Tuberculosis', 'Inflammation-play-Diabetes Mellitus, Type 2', 'Airway Obstruction-undergo-Drug Hypersensitivity', 'Death-diagnosed-Chordoma', 'Hip Fractures-develop-Myocardial Infarction', 'Neoplasms-affect-Death', 'Fatigue-apply-Neoplasms', 'Fatigue-detect-Neoplasms', 'Neoplasms-affect-Neoplasm Metastasis', 'Fatigue-shown-Arthritis, Rheumatoid', 'Fatigue-contribute-Pain', 'Stroke-treat-Death', 'Gastrointestinal Hemorrhage-eradicate-Infections', 'Syncope-validated-Heart Diseases', 'Pneumococcal Infections-lead-Death', 'Stroke-lower-Death', 'Cerebral Infarction-occur-Stroke', 'Death-sustain-Fractures, Bone', 'Infections-compare-Myocardial Infarction', 'Spinal Injuries-compare-Fractures, Bone', 'Spinal Injuries-show-Fractures, Bone', 'Infections-associated-Myocardial Infarction', 'Myocardial Infarction-associated-Infections', 'Metabolic Syndrome-prove-Cardiovascular Diseases', 'Spinal Cord Injuries-related-Fractures, Bone', 'Lupus Erythematosus, Systemic-exhibit-Tetany', 'Myasthenia Gravis-exhibit-Tetany', 'Metabolic Syndrome-prove-Diabetes Mellitus, Type 2', 'Cerebral Amyloid Angiopathy-associated-Dementia', 'Dementia-associated-Cerebral Amyloid Angiopathy', 'Spinal Cord Injuries-cause-Death', 'Osteoarthritis-cause-Arthralgia', 'Arthritis-cause-Arthralgia', 'Neoplasms-compare-Urinary Bladder Neoplasms', 'Atherosclerosis-perform-Cardiovascular Diseases', 'Pulmonary Disease, Chronic Obstructive-lead-Emphysema', 'Pulmonary Disease, Chronic Obstructive-associated-Ventricular Dysfunction, Left', 'Ventricular Dysfunction, Left-associated-Pulmonary Disease, Chronic Obstructive', 'Emphysema-associated-Ventricular Dysfunction, Left', 'Ventricular Dysfunction, Left-associated-Emphysema', 'Breast Neoplasms-hinder-Neutropenia', 'Inflammation-include-Skin Diseases', 'Fever-caused-Boutonneuse Fever', 'Multiple Organ Failure-defined-Death', 'Pulmonary Disease, Chronic Obstructive-become-Emphysema', 'Retroperitoneal Neoplasms-occur-Wounds and Injuries', 'Arthralgia-predict-Arthritis', 'Gastritis-suggested-Stomach Neoplasms', 'Lung Neoplasms-performed-Death', 'Pneumonia-contribute-Death', 'Venous Insufficiency-associated-Multiple Sclerosis', 'Multiple Sclerosis-associated-Venous Insufficiency', 'Inflammation-involved-Cardiovascular Diseases', 'Head and Neck Neoplasms-account-Neoplasms', 'Plaque, Amyloid-associated-Alzheimer Disease', 'Alzheimer Disease-associated-Plaque, Amyloid', 'Lipodystrophy-occur-HIV Infections', 'Gastrointestinal Hemorrhage-compared-Renal Insufficiency, Chronic', 'Anterior Cruciate Ligament Injuries-observed-Osteoarthritis', 'Anterior Cruciate Ligament Injuries-observed-Joint Diseases', 'Acute Coronary Syndrome-linked-Death', 'Myocardial Infarction-linked-Acute Coronary Syndrome', 'Death-linked-Acute Coronary Syndrome', 'Aphasia-think-Alzheimer Disease', 'Malocclusion-include-Headache Disorders, Secondary', 'Fractures, Bone-associated-Spinal Cord Injuries', 'Spinal Cord Injuries-associated-Fractures, Bone', 'Hepatitis C-become-Death', 'Hepatitis C-become-Infections', 'Spinal Cord Diseases-associated-Fractures, Bone', 'Fractures, Bone-associated-Spinal Cord Diseases', 'Hypotension-become-Death', 'Hyperuricemia-accelerate-Acute Kidney Injury', 'Bone Diseases-associated-Dystonia', 'Dystonia-associated-Bone Diseases', 'Flatfoot-related-Death', 'Immunologic Deficiency Syndromes-result-Osteoporotic Fractures', 'Neurologic Manifestations-appear-Sleep Initiation and Maintenance Disorders', 'Postoperative Cognitive Complications-lead-Respiratory Tract Infections', 'Postoperative Cognitive Complications-lead-Death', 'Myocardial Infarction-recorded-Acute Coronary Syndrome', 'Cardiomyopathy, Hypertrophic-characterized-Mastocytosis, Systemic', 'Stroke-associated-Cerebrovascular Trauma', 'Cerebrovascular Trauma-associated-Stroke', 'Cerebrovascular Disorders-expected-Death', 'Psychoses, Substance-Induced-develop-Dementia', 'Thyroid Neoplasms-control-Death', 'Obesity-affect-Death', 'Trigeminal Neuralgia-characterized-Shock', 'Trigeminal Neuralgia-characterized-Pain', 'Pain-characterized-Shock', 'Aneurysm-result-Diabetes Mellitus', 'Infections-result-Diabetes Mellitus', 'Neoplasms-include-Peripheral Nervous System Diseases', 'Osteoporosis-characterized-Pain', 'Osteoporosis-characterized-Death', 'Arbovirus Infections-recover-Infections', 'Tennis Elbow-show-Hyperplasia', 'Heart Diseases-associated-Vision Disorders', 'Vision Disorders-associated-Heart Diseases', 'Hematoma-found-Blood Coagulation Disorders', 'Lung Diseases-associated-Obesity, Abdominal', 'Obesity, Abdominal-associated-Lung Diseases', 'Stroke-exist-Cerebrovascular Disorders', 'Colonic Neoplasms-estimated-Neoplasms', 'Multiple Myeloma-cause-Death', 'Calculi-originate-Fistula', 'Gallstones-treated-Fistula', 'Osteoporosis-compare-Fractures, Bone', 'Neoplasms-hospitalized-Venous Thromboembolism', 'Menorrhagia-associated-Myoma', 'Myoma-associated-Menorrhagia', 'Death-occur-Infections', 'Delirium-identified-Death', 'Renal Insufficiency, Chronic-reach-Kidney Failure, Chronic', 'Hypothermia-contribute-Death', 'Diabetes Mellitus-show-Memory Disorders', 'Pulmonary Disease, Chronic Obstructive-noted-Hip Fractures', 'Pulmonary Disease, Chronic Obstructive-undergo-Hip Fractures', 'Endocarditis-present-Renal Insufficiency', 'Endocarditis-cause-Heart Failure', 'Endocarditis-affect-Death', 'Chronic Disease-cause-Heart Failure', 'Chronic Disease-affect-Death', 'Death, Sudden-cause-Heart Failure', 'Death, Sudden-affect-Death', 'Heart Failure-affect-Death', 'Skin Diseases-associated-Death', 'Death-associated-Skin Diseases', 'Nervous System Diseases-apply-Stroke', 'Osteoarthritis-performed-Death', 'Sepsis-associated-Dementia', 'Dementia-associated-Sepsis', 'Nervous System Diseases-associated-Dementia', 'Dementia-associated-Nervous System Diseases', 'Spinal Cord Diseases-diagnose-Multiple Sclerosis', 'Respiratory Distress Syndrome-related-Stroke', 'Atherosclerosis-manifest-Heart Arrest', 'Death-admitted-Hip Fractures', 'Intracranial Aneurysm-result-Headache', 'Death-develop-Acidosis, Lactic', 'Atherosclerosis-give-Cardiovascular Diseases', 'Atherosclerosis-used-Cardiovascular Diseases', 'Metabolic Syndrome-increase-Death', 'Metabolic Syndrome-associated-Myocardial Infarction', 'Myocardial Infarction-associated-Metabolic Syndrome', 'Metabolic Syndrome-associated-Renal Insufficiency', 'Renal Insufficiency-associated-Metabolic Syndrome', 'Fractures, Bone-increase-Headache', 'Sarcopenia-associated-Kidney Diseases', 'Kidney Diseases-associated-Sarcopenia', 'Death-increase-Renal Insufficiency', 'Death-related-Malaria', 'Atherosclerosis-include-Cerebrovascular Disorders', 'Thyroid Neoplasms-register-Neoplasms', 'Sensation Disorders-result-Neurologic Manifestations', 'Peripheral Nervous System Diseases-result-Neurologic Manifestations', 'Glaucoma-comprise-Neurodegenerative Diseases', 'Renal Insufficiency-derived-Death', 'Death-attributed-Renal Insufficiency', 'Death, Sudden, Cardiac-include-Cardiovascular Diseases', 'Obesity-followed-Weight Loss', 'Heart Failure-include-Death, Sudden, Cardiac', 'Psoriasis-affected-Neoplasms', 'Psoriasis-known-Skin Neoplasms', 'Psoriasis-known-Lymphoma', 'Psoriasis-known-Melanoma', 'Psoriasis-carry-Lymphoma', 'Stroke-distort-Leukoencephalopathies', 'Stroke-distort-Atrophy', 'Alzheimer Disease-cause-Memory Disorders', 'Coronary Artery Disease-measure-Hypothyroidism', 'Heart Failure-measure-Hypothyroidism', 'Death-attributed-Chronic Disease', 'Hypertension-identified-Hip Fractures', 'Wounds and Injuries-attributed-Chronic Disease', 'Glucose Intolerance-indicate-Diabetes Mellitus', 'Dementia-diagnosed-Atrial Fibrillation', 'Diarrhea-become-Sepsis', 'Diarrhea-cause-Dehydration', 'Osteoporotic Fractures-represent-Death', 'Wounds and Injuries-queried-Wounds, Nonpenetrating', 'Leukoaraiosis-reflect-Cerebral Small Vessel Diseases', 'Cerebral Small Vessel Diseases-reflect-Leukoaraiosis', 'Digestive System Neoplasms-increase-Death', 'Kidney Diseases-cause-Kidney Failure, Chronic', 'Kidney Diseases-known-Basal Ganglia Cerebrovascular Disease', 'Glomerulonephritis-cause-Kidney Failure, Chronic', 'Glomerulonephritis-known-Basal Ganglia Cerebrovascular Disease', 'Kidney Failure, Chronic-known-Basal Ganglia Cerebrovascular Disease', 'Atherosclerosis-demonstrate-Death', 'Appendicitis-considered-Abdominal Pain', 'Death-vary-Brain Injuries, Traumatic', 'Brain Injuries, Traumatic-increase-Death', 'Leukoencephalopathies-associated-Hepatomegaly', 'Hepatomegaly-associated-Leukoencephalopathies', 'Leukoencephalopathies-associated-Atrophy', 'Atrophy-associated-Leukoencephalopathies', 'Musculoskeletal Diseases-lead-Pain', 'Carotid Artery Diseases-assessed-Dementia', 'Prostatic Intraepithelial Neoplasia-upregulated-Carcinoma, Squamous Cell', 'Neoplasms-upregulated-Carcinoma, Squamous Cell', 'Lung Neoplasms-queried-Carcinoma, Non-Small-Cell Lung', 'Carotid Artery Diseases-associated-Dementia', 'Dementia-associated-Carotid Artery Diseases', 'Peripheral Arterial Disease-increase-Diabetes Mellitus', 'Death-continue-HIV Infections', 'Atrophy-affected-Alzheimer Disease', 'Cerebral Small Vessel Diseases-reported-Cerebral Infarction', 'Cerebral Small Vessel Diseases-reported-Diabetes Mellitus', 'Aniseikonia-attributed-Retinal Detachment', 'Aniseikonia-attributed-Retinal Degeneration', 'Neoplasms-continue-Death', 'Fatty Liver-lead-Chemical and Drug Induced Liver Injury', 'Fatty Liver-lead-Inflammation', 'Brain Neoplasms-attributed-Death', 'Brain Neoplasms-associated-Death', 'Death-associated-Brain Neoplasms', 'Glomerulonephritis-include-Acute Kidney Injury', 'Death-influence-Neoplasms', 'Hypertension-impair-Diabetes Mellitus', 'Death-related-Aortic Aneurysm', 'Death-listed-Aortic Aneurysm', 'Death-associated-Arbovirus Infections', 'Arbovirus Infections-associated-Death', 'Anorexia-lead-Weight Loss', 'Anorexia-lead-Sarcopenia', 'Anorexia-lead-Death', 'Renal Insufficiency, Chronic-seen-Diabetes Mellitus, Type 2', 'Renal Insufficiency, Chronic-remain-Albuminuria', 'Diabetes Mellitus, Type 2-remain-Albuminuria', 'Mesothelioma-use-Death', 'Asbestosis-use-Death', 'Uremia-reduce-Kidney Failure, Chronic', 'Alzheimer Disease-associated-Leukoencephalopathies', 'Leukoencephalopathies-associated-Alzheimer Disease', 'Wounds and Injuries-identify-Fractures, Bone', 'Anemia-investigated-Neoplasms', 'Dementia-associated-Acute Coronary Syndrome', 'Acute Coronary Syndrome-associated-Dementia', 'Acute Coronary Syndrome-hospitalized-Dementia', 'Hip Fractures-impact-Death', 'Inflammation-involved-Kidney Diseases', 'Diabetes Mellitus-identify-Osteomyelitis', 'Diabetes Mellitus-identify-Ulcer', 'Pneumonia, Aspiration-regarded-Pneumonia', 'Death-considered-Pneumonia, Aspiration', 'Pneumonia, Aspiration-consider-Death', 'Pneumonia-followed-Bronchiolitis', 'Pneumonia-present-Bronchiolitis', 'Bronchiolitis-followed-Bronchopneumonia', 'Bronchiolitis-present-Deglutition Disorders', 'Neoplasms-monitored-Arthritis, Psoriatic', 'Neoplasms-monitored-Diabetes Mellitus', 'Arthritis, Psoriatic-monitored-Diabetes Mellitus', 'Coma-provide-Wounds and Injuries', 'Craniocerebral Trauma-associated-Trauma, Nervous System', 'Trauma, Nervous System-associated-Craniocerebral Trauma', 'Glucose Metabolism Disorders-suggest-Dementia', 'Diabetes Mellitus-become-Obesity', 'Heart Failure-become-Obesity', 'Alzheimer Disease-require-Amyloidosis', 'Fatigue-predict-Coronary Artery Disease', 'Fatigue-predict-Death', 'Fatigue-predict-Cardiovascular Diseases', 'Diabetes Mellitus-experience-Diabetic Nephropathies', 'Osteoporosis-address-Osteoporotic Fractures', 'Death-relate-Breast Neoplasms', 'Skin Diseases-lead-Rosacea', 'Obesity-thought-Death', 'Fatigue-progress-Nausea', 'Anorexia-progress-Nausea', 'Anorexia-progress-Vomiting', 'HIV Infections-live-Death', 'Anorexia-progress-Arthralgia', 'Anorexia-progress-Jaundice', 'Wounds and Injuries-include-Death', 'Myelodysplastic Syndromes-result-Hematologic Diseases', 'Stroke-decrease-Obesity', 'Myelodysplastic Syndromes-result-Leukemia, Myeloid, Acute', 'Death-decrease-Obesity', 'Death-diagnosed-Breast Neoplasms', 'Obesity-document-Death', 'Stroke-document-Death', 'Craniocerebral Trauma-known-Death', 'Neoplasms-influence-Death', 'Status Epilepticus-characterized-Persistent Vegetative State', 'Status Epilepticus-characterized-Seizures', 'Fractures, Bone-related-Sleep Initiation and Maintenance Disorders', 'Seizures-characterized-Persistent Vegetative State', 'Death-benefit-Infections', 'Urinary Bladder, Overactive-associated-Nocturia', 'Nocturia-associated-Urinary Bladder, Overactive', 'Sarcopenia-predict-Neoplasms', 'Heart Failure-treated-Ventricular Dysfunction, Left', 'Heart Failure-result-Ventricular Dysfunction, Left', 'Hip Fractures-develop-Delirium', 'Ventricular Dysfunction, Left-treated-Heart Failure', 'Heart Failure-account-Death', 'Stroke-continue-Cerebral Infarction', 'Stroke-continue-Death', 'Hepatitis C-known-Hepatitis B', 'Hepatitis C-known-Chemical and Drug Induced Liver Injury', 'HIV Infections-recruited-Acquired Immunodeficiency Syndrome', 'Death-use-Sepsis', 'Death-use-Renal Insufficiency', 'Infections-proposed-Death', 'HIV Infections-proposed-Death', 'Non-alcoholic Fatty Liver Disease-related-Aortic Diseases', 'Death-develop-Renal Insufficiency', 'Neoplasms-conduct-Colonic Neoplasms', 'Dementia-manage-Hypertension', 'Non-alcoholic Fatty Liver Disease-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-Non-alcoholic Fatty Liver Disease', 'Diabetes Mellitus-include-Hepatitis, Viral, Human', 'Non-alcoholic Fatty Liver Disease-associated-Coronary Artery Disease', 'Coronary Artery Disease-associated-Non-alcoholic Fatty Liver Disease', 'Genetic Diseases, Inborn-characterized-Diabetes Insipidus', 'Genetic Diseases, Inborn-characterized-Diabetes Mellitus', 'Genetic Diseases, Inborn-characterized-Optic Atrophy', 'Atrophy-obtained-Spinal Cord Injuries', 'Hematoma, Subdural, Chronic-associated-Death', 'Death-associated-Hematoma, Subdural, Chronic', 'Eye Diseases-associated-Vision Disorders', 'Vision Disorders-associated-Eye Diseases', 'Heart Failure-co-exist-Atrial Fibrillation', 'Erectile Dysfunction-include-Sexual Dysfunction, Physiological', 'Death-associated-Arthritis, Psoriatic', 'Arthritis, Psoriatic-associated-Death', 'Deaf-Blind Disorders-include-Vision Disorders', 'Mitochondrial Diseases-reported-Muscle Weakness', 'Mitochondrial Diseases-reported-Respiratory Insufficiency', 'Stroke-examine-Ossification of Posterior Longitudinal Ligament', 'Arthritis, Psoriatic-increased-Death', 'Takotsubo Cardiomyopathy-adopted-Ischemia', 'Neoplasms-observed-Lupus Erythematosus, Systemic', 'Hypertension-change-Hypotension', 'Colorectal Neoplasms-function-Prostatic Neoplasms', 'Hypertension-complicated-Renal Insufficiency, Chronic', 'Hypertension-recommend-Renal Insufficiency, Chronic', 'Pain-associated-Cartilage Diseases', 'Cartilage Diseases-associated-Pain', 'Albuminuria-correlated-Proteinuria', 'Hemangiosarcoma-kept-Neoplasms', 'Common Cold-cause-Hearing Loss', 'Immunologic Deficiency Syndromes-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-Immunologic Deficiency Syndromes', 'Melanoma-selected-Neoplasms', 'Carcinoma, Squamous Cell-made-Neoplasms', 'Coma-admitted-Wounds and Injuries', 'Inflammation-play-Dermatitis, Atopic', 'Death-decrease-Stroke', 'Aortic Diseases-associated-Death', 'Death-associated-Aortic Diseases', 'Stroke-ascertain-Death', 'Atrioventricular Block-complicate-Heart Defects, Congenital', 'Alzheimer Disease-improve-Memory Disorders', 'Death-related-Hypertension', 'Gastric Outlet Obstruction-associate-Death', 'Death-associate-Gastric Outlet Obstruction', 'Immunologic Deficiency Syndromes-contribute-Glucose Metabolism Disorders', 'Wounds and Injuries-diagnosed-Venous Thromboembolism', 'Hirsutism-referred-Polycystic Ovary Syndrome', 'Immunologic Deficiency Syndromes-contribute-Diabetes Mellitus', 'Urticaria-follow-Drug Eruptions', 'Osteoporosis-found-HIV Infections', 'Hypotension-compare-Fibromyalgia', 'Hypotension-show-Fibromyalgia', 'Retinal Detachment-associated-Choroidal Effusions', 'Choroidal Effusions-associated-Retinal Detachment', 'Retinal Detachment-occur-Myopia', 'Retinal Detachment-associated-Ocular Hypertension', 'Ocular Hypertension-associated-Retinal Detachment', 'Carotid Stenosis-caused-Atherosclerosis', 'Embolism-identify-Cerebral Infarction', 'Embolism-identify-Cerebrovascular Disorders', 'Mitochondrial Diseases-related-Metabolic Diseases', 'Pain-presented-Mouth Diseases', 'Myocardial Infarction-associated-Cardiomyopathy, Dilated', 'Cardiomyopathy, Dilated-associated-Myocardial Infarction', 'Myocardial Infarction-associated-Heart Diseases', 'Heart Diseases-associated-Myocardial Infarction', 'Acute Disease-impair-Status Epilepticus', 'Atrial Fibrillation-determine-Death', 'Bacteremia-cause-Death', 'Arrhythmias, Cardiac-determine-Death', 'Erectile Dysfunction-suffer-Chronic Disease', 'Carcinoma, Hepatocellular-associated-Chemical and Drug Induced Liver Injury', 'Chemical and Drug Induced Liver Injury-associated-Carcinoma, Hepatocellular', 'Lung Neoplasms-limited-Death', 'Osteoporotic Fractures-include-Spinal Fractures', 'Spinal Fractures-caused-Neoplasms', 'Moyamoya Disease-characterized-Constriction, Pathologic', 'Cerebrovascular Disorders-characterized-Constriction, Pathologic', 'Stroke-increase-Hypertension', 'Peripheral Arterial Disease-increase-Hypertension', 'Peripheral Arterial Disease-decrease-Death', 'Diabetes Mellitus-increase-Hypertension', 'Diabetes Mellitus-decrease-Death', 'Infections-associated-Acquired Immunodeficiency Syndrome', 'Acquired Immunodeficiency Syndrome-associated-Infections', 'Renal Insufficiency-increase-Hypertension', 'Renal Insufficiency-decrease-Death', 'Anemia-increase-Hypertension', 'Anemia-decrease-Death', 'Death-increase-Hypertension', 'Drug-Related Side Effects and Adverse Reactions-result-Cerebrovascular Disorders', 'Hypertension-decrease-Death', 'Aneurysm-present-Rupture', 'Airway Obstruction-quantify-Pelvic Floor Disorders', 'Neoplasms-identify-Carcinoma, Non-Small-Cell Lung', 'Neoplasm Metastasis-threat-Prostatic Neoplasms', 'Anemia-undergo-Hip Fractures', 'Cardiomyopathies-present-Stroke', 'Kidney Diseases-recommend-Bone Diseases', 'Kidney Diseases-recommend-Fractures, Bone', 'Venous Thromboembolism-associated-Lymphoma', 'Lymphoma-associated-Venous Thromboembolism', 'Glaucoma-evaluate-Ocular Hypertension', 'Anemia-include-Hemorrhage', 'Atrial Fibrillation-develop-Acute Kidney Injury', 'Hypothyroidism-accompanied-Acute Kidney Injury', 'Atrial Fibrillation-develop-Gastrointestinal Hemorrhage', 'Hypothyroidism-accompanied-Sleep Initiation and Maintenance Disorders', 'Atrophy-related-Pain', 'Atrophy-involved-Pain', 'Cerebral Infarction-classified-Stroke, Lacunar', 'Liver Failure-develop-Carcinoma, Hepatocellular', 'Liver Failure-develop-Infections', 'Carcinoma, Hepatocellular-develop-Infections', 'Gastroenteritis-identified-Death', 'Gastroenteritis-recognized-Death', 'Death-associated-Gastroenteritis', 'Gastroenteritis-associated-Death', 'Neurologic Manifestations-described-Dementia', 'Neurologic Manifestations-described-Alzheimer Disease', 'Hyponatremia-associated-Pneumonia', 'Pneumonia-associated-Hyponatremia', 'Hyponatremia-associated-Pneumonia, Aspiration', 'Pneumonia, Aspiration-associated-Hyponatremia', 'Oligomenorrhea-associated-Metabolic Syndrome', 'Metabolic Syndrome-associated-Oligomenorrhea', 'Polycystic Ovary Syndrome-associated-Metabolic Syndrome', 'Metabolic Syndrome-associated-Polycystic Ovary Syndrome', 'Colorectal Neoplasms-decrease-Cardiac Output, Low', 'Atherosclerosis-develop-Thrombosis', 'Inflammation-found-Coronary Artery Disease', 'Hemorrhage-found-Coronary Artery Disease', 'Malaria-include-Malaria, Falciparum', 'Malaria-include-Death', 'Arthritis, Rheumatoid-include-Autoimmune Diseases', 'Autoimmune Diseases-associated-Lymphopenia', 'Lymphopenia-associated-Autoimmune Diseases', 'Arthritis, Rheumatoid-associated-Lymphopenia', 'Lymphopenia-associated-Arthritis, Rheumatoid', 'Dyslipidemias-include-Diabetes Mellitus', 'Proteinuria-include-Diabetes Mellitus', 'Pain-preserved-Dementia', 'Metabolic Syndrome-use-Obesity', 'Stroke-treat-Vision Disorders', 'Diabetes Mellitus-recognized-Alzheimer Disease', 'Malaria-produce-Malaria, Falciparum', 'Ankylosis-lead-Inflammation', 'Diabetes Mellitus-hospitalized-Communicable Diseases', 'Stroke-hospitalized-Communicable Diseases', 'Osteoporosis-undertreat-Fractures, Bone', 'Malnutrition-lead-Dementia', 'Gastritis, Atrophic-characterized-Stomach Diseases', 'Hematoma-present-Intracranial Hemorrhages', 'Hematoma-recorded-Death', 'Colitis, Ischemic-regarded-Hypertension', 'Colitis, Ischemic-regarded-Communicable Diseases', 'Colitis, Ischemic-develop-Hypertension', 'Hydrocephalus-extracted-Infections', 'Weight Loss-live-Sleep Apnea, Obstructive', 'Neoplasms-occur-Uterine Cervical Neoplasms', 'Rhinitis-referred-Drug Hypersensitivity', 'Fractures, Bone-exclude-Osteoporotic Fractures', 'Osteoporotic Fractures-exclude-Fractures, Bone', 'Hypertension-associated-Cerebral Hemorrhage', 'Cerebral Hemorrhage-associated-Hypertension', 'Hypertension-compare-Cerebral Infarction', 'Hypertension-associated-Subarachnoid Hemorrhage', 'Subarachnoid Hemorrhage-associated-Hypertension', 'Atherosclerosis-considered-Blepharoptosis', 'Inflammation-determine-Cardiovascular Diseases', 'Inflammation-determine-Death', 'Kyphosis-clarify-Obesity', 'Aortic Aneurysm, Thoracic-undergo-Aneurysm', 'Kyphosis-clarify-Osteoporosis', 'Metabolic Diseases-affect-Diabetes Mellitus', 'Hypertension-assess-Diabetes Mellitus', 'Cerebral Infarction-associated-Death', 'Death-associated-Cerebral Infarction', 'Lung Neoplasms-associated-Neoplasms', 'Neoplasms-associated-Lung Neoplasms', 'Inflammatory Bowel Diseases-identified-Colitis, Ulcerative', 'Inflammatory Bowel Diseases-identified-Crohn Disease', 'Acute Kidney Injury-associated-Kidney Diseases', 'Kidney Diseases-associated-Acute Kidney Injury', 'Parkinson Disease-occur-Primary Dysautonomias', 'Renal Insufficiency, Chronic-include-Acute Kidney Injury', 'Shock, Cardiogenic-include-Acute Kidney Injury', 'Diabetes Mellitus-include-Acute Kidney Injury', 'Heart Failure-include-Acute Kidney Injury', 'Parkinson Disease-involve-Cardiovascular Diseases', 'Acute Kidney Injury-continue-Kidney Diseases', 'Death-compare-Leukemia, Myelogenous, Chronic, BCR-ABL Positive', 'Death-assessed-Myocarditis', 'Heart Diseases-assessed-Myocarditis', 'Hypercalcemia-result-Hyperparathyroidism', 'Hypercalcemia-cause-Dystonia', 'Hypercalcemia-cause-Muscle Weakness', 'Hypotension-identified-Heart Failure', 'Hyperparathyroidism-cause-Dystonia', 'Hyperparathyroidism-cause-Muscle Weakness', 'Neurodegenerative Diseases-occur-Uterine Cervicitis', 'Renal Insufficiency, Chronic-predict-Death', 'Polymyalgia Rheumatica-associated-Inflammation', 'Inflammation-associated-Polymyalgia Rheumatica', 'Polymyalgia Rheumatica-improve-Inflammation', 'Proteinuria-predict-Death', 'Cerebral Hemorrhage-related-Cerebral Amyloid Angiopathy', 'Epilepsy, Absence-compare-Tinnitus', 'Epilepsy, Absence-hear-Tinnitus', 'Vascular System Injuries-perform-Anophthalmos', 'Pain-restore-End Stage Liver Disease', 'Ocular Hypertension-explained-Myopia', 'Kidney Failure, Chronic-predict-Kidney Diseases', 'Hyperthyroidism-influence-Heart Failure', 'Immunologic Deficiency Syndromes-arise-Malabsorption Syndromes', 'Lung Neoplasms-tolerate-Death', 'Obesity-examined-Hypertension', 'Brain Infarction-contribute-Dementia', 'Hypothyroidism-associated-Coronary Artery Disease', 'Coronary Artery Disease-associated-Hypothyroidism', 'Non-alcoholic Fatty Liver Disease-associated-Obesity, Abdominal', 'Obesity, Abdominal-associated-Non-alcoholic Fatty Liver Disease', 'Non-alcoholic Fatty Liver Disease-associated-Metabolic Diseases', 'Metabolic Diseases-associated-Non-alcoholic Fatty Liver Disease', 'Subdural Effusion-develop-Hydrocephalus', 'Fatty Liver-associate-Metabolic Diseases', 'Metabolic Diseases-associate-Fatty Liver', 'Fractures, Bone-reduce-Osteoporotic Fractures', 'Infarction-associated-Dementia', 'Dementia-associated-Infarction', 'Hypothyroidism-associated-Metabolic Syndrome', 'Metabolic Syndrome-associated-Hypothyroidism', 'Death, Sudden-remain-Death', 'Death, Sudden-remain-Heart Failure, Systolic', 'Ventricular Fibrillation-remain-Death', 'Ventricular Fibrillation-remain-Heart Failure, Systolic', 'Atherosclerosis-result-Sarcopenia', 'Atherosclerosis-result-Frailty', 'Muscular Diseases-improve-Sarcopenia', 'Hepatitis, Viral, Human-include-Infections', 'Drug-Related Side Effects and Adverse Reactions-include-Infections', 'Death-affect-Chronic Disease', 'Diabetes Mellitus-compare-Dementia', 'Osteoporosis-predispose-Fractures, Bone', 'Fractures, Bone-result-Death', 'Nephritis, Interstitial-considered-Acute Kidney Injury', 'Nephritis, Interstitial-encountered-Infections', 'Bone Neoplasms-ameliorate-Spinal Cord Injuries', 'Osteoarthritis-give-Pain', 'Venous Insufficiency-differ-Venous Thrombosis', 'Obesity-linked-Metabolic Syndrome', 'Retinal Diseases-found-Diabetes Mellitus', 'Bone Diseases-predispose-Fractures, Bone', 'Anemia-associated-Drug-Related Side Effects and Adverse Reactions', 'Drug-Related Side Effects and Adverse Reactions-associated-Anemia', 'Obesity-associated-Drug-Related Side Effects and Adverse Reactions', 'Drug-Related Side Effects and Adverse Reactions-associated-Obesity', 'Stroke-include-Cerebrovascular Disorders', 'Anorexia-lead-Malnutrition', 'Spinal Stenosis-result-Hypertrophy', 'Hearing Loss-receive-Inflammation', 'Diabetes Mellitus-influence-Arteriovenous Fistula', 'Peripheral Vascular Diseases-influence-Arteriovenous Fistula', 'Hypotension-influence-Arteriovenous Fistula', 'Polymyalgia Rheumatica-associated-Stroke', 'Stroke-associated-Polymyalgia Rheumatica', 'Chronic Disease-include-Inflammation', 'Chronic Disease-involve-Inflammation', 'Hypogonadism-associated-Immunologic Deficiency Syndromes', 'Immunologic Deficiency Syndromes-associated-Hypogonadism', 'Neoplasms-identified-Colorectal Neoplasms', 'Carcinoma, Hepatocellular-identify-Fibrosis', 'Hypotension-increase-Neoplasms', 'Headache Disorders, Primary-occur-Sleep Wake Disorders', 'Inflammation-caused-Hepatitis B', 'Headache-occur-Sleep Wake Disorders', 'Inflammation-caused-Hepatitis C', 'Inflammation-lead-Fibrosis', 'Inflammation-lead-Carcinoma, Hepatocellular', 'Acute Kidney Injury-compare-Diabetes Mellitus', 'Gallstones-evaluated-Skin Diseases', 'Hepatitis B-compare-Carcinoma, Hepatocellular', 'Neoplasms-evaluated-Iatrogenic Disease', 'Death-used-Wounds and Injuries', 'Death-assess-Wounds and Injuries', 'Death-differ-Cardiovascular Diseases', 'Trauma, Nervous System-associated-Death', 'Death-associated-Trauma, Nervous System', 'Tachycardia, Supraventricular-result-Syncope', 'Tachycardia, Supraventricular-result-Myocardial Infarction', 'Hypertension-include-Hypotension', 'Arrhythmias, Cardiac-result-Syncope', 'Arrhythmias, Cardiac-result-Myocardial Infarction', 'Death-complete-Tuberculosis', 'Acquired Immunodeficiency Syndrome-define-Multiple Chronic Conditions', 'Acquired Immunodeficiency Syndrome-define-Diabetes Mellitus', 'Acquired Immunodeficiency Syndrome-define-Lung Diseases, Obstructive', 'Acquired Immunodeficiency Syndrome-define-Liver Diseases', 'Acquired Immunodeficiency Syndrome-define-Anemia', 'Acquired Immunodeficiency Syndrome-define-Obesity', 'Acquired Immunodeficiency Syndrome-define-Kidney Diseases', 'Acquired Immunodeficiency Syndrome-define-Hypertension', 'Death-used-Arbovirus Infections', 'Metabolic Syndrome-related-Hyperuricemia', 'Heart Septal Defects, Atrial-improve-Death', 'Dementia-lose-Weight Loss', 'Sleep Wake Disorders-associated-Kidney Failure, Chronic', 'Kidney Failure, Chronic-associated-Sleep Wake Disorders', 'Hypoxia-exacerbate-Coinfection', 'Immunologic Deficiency Syndromes-mediated-Cerebral Infarction', 'Neoplasms-ensure-Pain', 'Nocturia-cited-Sleep Wake Disorders', 'Nocturia-cited-Fatigue', 'Hemostatic Disorders-enable-Hemorrhage', 'Tuberculosis-associated-Death', 'Death-associated-Tuberculosis', 'Stroke-comprise-Hemiplegia', 'Frailty-associated-Death', 'Death-associated-Frailty', 'Diabetes Mellitus-associated-Pancreatic Neoplasms', 'Pancreatic Neoplasms-associated-Diabetes Mellitus', 'Fractures, Bone-associated-Blood Loss, Surgical', 'Blood Loss, Surgical-associated-Fractures, Bone', 'Ascites-misdiagnosed-Peritoneal Neoplasms', 'Diabetes Mellitus-evaluated-Hereditary Breast and Ovarian Cancer Syndrome', 'Peritonitis, Tuberculous-misdiagnosed-Peritoneal Neoplasms', 'Fractures, Bone-screened-Osteoporosis', 'Stomach Neoplasms-present-Drug-Related Side Effects and Adverse Reactions', 'Ovarian Neoplasms-complicated-Ascites', 'Ovarian Neoplasms-complicated-Stomach Neoplasms', 'Ascites-complicated-Stomach Neoplasms', 'Drug-Related Side Effects and Adverse Reactions-considered-Stomach Neoplasms', 'Aneurysm-associated-Tricuspid Valve Insufficiency', 'Tricuspid Valve Insufficiency-associated-Aneurysm', 'Thrombosis-originate-Stomach Neoplasms', 'Heart Diseases-use-Death', 'Hypothyroidism-induce-Hyperthyroidism', 'Urinary Bladder Neoplasms-tend-Neoplasms', 'Infarction-include-Cerebrovascular Disorders', 'Arteriolosclerosis-include-Cerebrovascular Disorders', 'Parkinsonian Disorders-unrecognized-Cerebrovascular Disorders', 'Neoplasms-followed-Asthma', 'Neoplasms-stratify-Death', 'Diabetes Mellitus-relate-Hypogonadism', 'Death-reduce-Aortic Aneurysm', 'Sepsis-combined-Death', 'Dyskinesia, Drug-Induced-associated-Central Nervous System Diseases', 'Central Nervous System Diseases-associated-Dyskinesia, Drug-Induced', 'Opportunistic Infections-associated-Diarrhea', 'Diarrhea-associated-Opportunistic Infections', 'Psychoses, Substance-Induced-associated-Central Nervous System Diseases', 'Central Nervous System Diseases-associated-Psychoses, Substance-Induced', 'Opportunistic Infections-associated-Acquired Immunodeficiency Syndrome', 'Acquired Immunodeficiency Syndrome-associated-Opportunistic Infections', 'Colorectal Neoplasms-encounter-Critical Illness', 'Chondrocalcinosis-associated-Osteoarthritis', 'Osteoarthritis-associated-Chondrocalcinosis', 'Neoplasms-carry-Death', 'Infarction-associated-Heart Failure', 'Heart Failure-associated-Infarction', 'Infarction-associated-Stroke', 'Stroke-associated-Infarction', 'Infarction-associated-Death', 'Death-associated-Infarction', 'Infarction-associated-Ischemia', 'Ischemia-associated-Infarction', 'Infarction-associated-Angina Pectoris', 'Angina Pectoris-associated-Infarction', 'Infarction-associated-Myocardial Infarction', 'Myocardial Infarction-associated-Infarction', 'Carcinoma-comprise-Rheumatic Diseases', 'Aneurysm-identify-Heart Failure', 'Arthritis-comprise-Rheumatic Diseases', 'Aneurysm-identify-Stroke', 'Aneurysm-identify-Death', 'Amyloidosis-proven-Heart Failure', 'Hypertension-associated-Cerebrovascular Trauma', 'Cerebrovascular Trauma-associated-Hypertension', 'Hypertension-associated-Atrophy', 'Atrophy-associated-Hypertension', 'Diabetes Mellitus-associated-Cerebrovascular Trauma', 'Cerebrovascular Trauma-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-Atrophy', 'Atrophy-associated-Diabetes Mellitus', 'Obesity-associated-Cerebrovascular Trauma', 'Cerebrovascular Trauma-associated-Obesity', 'Obesity-associated-Atrophy', 'Atrophy-associated-Obesity', 'Coronary Artery Disease-coexist-Heart Diseases', 'Deglutition Disorders-describe-Aneurysm', 'Delirium-worsen-Dementia', 'Death-worsen-Dementia', 'Tooth Loss-associated-Fatigue', 'Fatigue-associated-Tooth Loss', 'Neoplasms-result-Carcinoma, Non-Small-Cell Lung', 'Muscular Atrophy-result-Kyphosis', 'Death-undergo-Gallbladder Diseases', 'Communicable Diseases-affect-Cerebrovascular Disorders', 'Death-admitted-Pneumonia', 'Airway Obstruction-suffer-Dementia', 'Chronic Disease-include-Hypertension', 'Chronic Disease-include-Asthma', 'Chronic Disease-include-Diabetes Mellitus', 'Dementia-undergo-Alzheimer Disease', 'Dementia-influence-Pulmonary Disease, Chronic Obstructive', 'Death-use-Musculoskeletal Diseases', 'Leukoencephalopathies-attributed-Cerebrovascular Disorders', 'Hepatitis C-cause-Death', 'Liver Diseases-become-Death', 'Musculoskeletal Diseases-follow-Optic Nerve Diseases', 'Musculoskeletal Diseases-follow-Osteoarthritis', 'Urethral Neoplasms-do-Kidney Failure, Chronic', 'Death-predict-Cerebral Infarction', 'Cerebral Infarction-linked-Kidney Diseases', 'Arrhythmias, Cardiac-associated-Heart Failure', 'Heart Failure-associated-Arrhythmias, Cardiac', 'Low Back Pain-compare-Pain', 'Atrial Fibrillation-associated-Ventricular Remodeling', 'Ventricular Remodeling-associated-Atrial Fibrillation', 'Diabetes Mellitus-occur-Metabolic Syndrome', 'Metabolic Syndrome-show-Diabetes Mellitus', 'Coinfection-shown-Infections', 'Kidney Diseases-used-Renal Insufficiency, Chronic', 'Eunuchism-identify-Ataxia Telangiectasia', 'Alzheimer Disease-link-Dementia, Vascular', 'Urolithiasis-treat-Renal Colic', 'Stroke-base-Death', 'Obesity-include-Diabetes Mellitus', 'Xerostomia-measure-Headache Disorders, Secondary', 'Venous Thrombosis-remain-Hemorrhage', 'Wounds and Injuries-associate-Osteoarthritis', 'Osteoarthritis-associate-Wounds and Injuries', 'Seizures-cause-Cardiovascular Diseases', 'Atherosclerosis-underlie-Coronary Artery Disease', 'Heart Failure-associated-Endocarditis', 'Endocarditis-associated-Heart Failure', 'Kidney Diseases-study-Death', 'Renal Insufficiency, Chronic-study-Death', 'Cardiovascular Diseases-play-Hearing Loss', 'Anemia-include-Hematologic Neoplasms', 'Anemia-reveal-Hematologic Neoplasms', 'Renal Insufficiency, Chronic-include-Hyperkalemia', 'Renal Insufficiency, Chronic-include-Hypotension, Orthostatic', 'Drug Hypersensitivity-associated-Motor Neuron Disease', 'Motor Neuron Disease-associated-Drug Hypersensitivity', 'Drug Hypersensitivity-associated-Metabolic Diseases', 'Metabolic Diseases-associated-Drug Hypersensitivity', 'Inflammation-associated-Motor Neuron Disease', 'Motor Neuron Disease-associated-Inflammation', 'Neoplasm Metastasis-detect-Melanoma', 'Heart Failure-characterized-Dyspnea', 'Heart Failure-characterized-Fatigue', 'Memory Disorders-represent-Alzheimer Disease', 'Dementia-represent-Alzheimer Disease', 'Obesity, Abdominal-evaluate-Chronic Disease', 'Obesity-evaluate-Chronic Disease', 'Myoclonus-associated-Neurodegenerative Diseases', 'Neurodegenerative Diseases-associated-Myoclonus', 'Myoclonus-associated-Retinal Degeneration', 'Retinal Degeneration-associated-Myoclonus', 'Eosinophilia-include-Rhinitis, Allergic', 'Amyloidosis-consult-Xerostomia', 'Amyloidosis-consult-Corneal Ulcer', 'Hereditary Breast and Ovarian Cancer Syndrome-lead-Facial Paralysis', 'Death-described-Wounds and Injuries', 'Death-exposed-Wounds and Injuries', 'Constipation-associated-Short Bowel Syndrome', 'Short Bowel Syndrome-associated-Constipation', 'Neoplasm Metastasis-cause-Hemorrhage', 'Neoplasm Metastasis-cause-Pain', 'Death-use-Myocardial Infarction', 'Myocardial Infarction-use-Cerebral Infarction', 'Cerebral Infarction-use-Myocardial Infarction', 'Myocardial Infarction-use-Heart Failure', 'Hypothermia-use-Heart Arrest', 'Hypothermia-treat-Heart Arrest', 'Hypothermia-use-Ventricular Fibrillation', 'Inflammation-associated-Ataxia', 'Ataxia-associated-Inflammation', 'Communicable Diseases-diagnosed-Fever', 'Aneurysm-relate-Dementia', 'Death-examine-Dementia', 'Nephrotic Syndrome-observed-Kidney Diseases', 'Nephrotic Syndrome-follow-Amyloidosis', 'Nephrotic Syndrome-observed-Glomerulosclerosis, Focal Segmental', 'Dementia-report-Death', 'Breast Neoplasms-sustain-Neoplasms', 'Ischemia-pose-Death', 'Thyroid Diseases-associated-Liver Diseases', 'Liver Diseases-associated-Thyroid Diseases', 'Hypertension-associated-Carpal Tunnel Syndrome', 'Carpal Tunnel Syndrome-associated-Hypertension', 'Arrhythmias, Cardiac-associated-Carpal Tunnel Syndrome', 'Carpal Tunnel Syndrome-associated-Arrhythmias, Cardiac', 'Venous Thromboembolism-repaired-Hernia, Hiatal', 'Hernia, Hiatal-repaired-Death', 'Stomach Neoplasms-compared-Tuberculosis', 'Stomach Neoplasms-identify-Tuberculosis', 'Osteoporosis-used-Dementia', 'Rhinitis-taken-Drug Hypersensitivity', 'Dermatitis, Atopic-taken-Drug Hypersensitivity', 'Ischemia-associated-Vasospasm, Intracranial', 'Vasospasm, Intracranial-associated-Ischemia', 'Carcinoma, Hepatocellular-accompanied-Hemorrhage', 'Immunologic Deficiency Syndromes-use-Genetic Diseases, Inborn', 'Neoplasms-driven-Acquired Immunodeficiency Syndrome', 'Neoplasms-associated-Edema', 'Edema-associated-Neoplasms', 'Sleep Wake Disorders-participate-Alzheimer Disease', 'Stroke-account-Epilepsy', 'Neurodegenerative Diseases-account-Epilepsy', 'Atherosclerosis-contribute-Cardiovascular Diseases', 'Arthritis, Juvenile-based-Neoplasms', 'Arthritis, Juvenile-based-Meningitis, Aseptic', 'Arthritis, Juvenile-based-Pericarditis', 'Arthritis, Juvenile-based-Fever', 'Hip Fractures-prevent-Fractures, Bone', 'Parkinson Disease-induce-Dyskinesia, Drug-Induced', 'Fractures, Bone-followed-Death', 'Death-associate-Coronary Artery Disease', 'Coronary Artery Disease-associate-Death', 'Neoplasms-fall-Cardiac Output, Low', 'Nausea-suggest-HIV Infections', 'Fatigue-suggest-HIV Infections', 'Diabetes Mellitus-increase-Optic Neuropathy, Ischemic', 'Chronic Kidney Disease-Mineral and Bone Disorder-associated-Death', 'Death-associated-Chronic Kidney Disease-Mineral and Bone Disorder', 'Chronic Kidney Disease-Mineral and Bone Disorder-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-Chronic Kidney Disease-Mineral and Bone Disorder', 'Dementia-take-Pain', 'Dementia-receive-Pain', 'Lung Diseases-associated-Heart Failure', 'Heart Failure-associated-Lung Diseases', 'Sepsis-fulfil-Shock, Septic', 'Common Cold-cause-Pain', 'Spinal Cord Injuries-involve-Nervous System Diseases', 'Spinal Cord Injuries-involve-Constriction, Pathologic', 'Nervous System Diseases-defined-Fractures, Bone', 'Aneurysm-associated-Heart Failure', 'Heart Failure-associated-Aneurysm', 'Heart Failure-associated-Hypertension, Pulmonary', 'Hypertension, Pulmonary-associated-Heart Failure', 'Kyphosis-applied-Colorectal Neoplasms', 'Vascular System Injuries-compared-Wounds and Injuries', 'Vascular System Injuries-use-Wounds and Injuries', 'Fractures, Bone-used-Hip Fractures', 'Fractures, Bone-treat-Hip Fractures', 'Arthritis-experience-Fractures, Bone', 'Death-imply-Kidney Diseases', 'Polyps-include-Colorectal Neoplasms', 'Diabetes Mellitus-increase-Hypoglycemia', 'Constipation-linked-Infections', 'Constipation-linked-Enuresis', 'Prostatic Diseases-rise-Obesity', 'Cerebral Infarction-registered-Stroke', 'Sleep Deprivation-increase-Hypertension', 'HIV Infections-associated-Fractures, Bone', 'Fractures, Bone-associated-HIV Infections', 'Multiple Myeloma-associated-Death', 'Death-associated-Multiple Myeloma', 'Hypertension-assess-Death', 'Death-compare-Hypertension', 'Alzheimer Disease-enhancing-Dementia', 'Soft Tissue Infections-become-Infections', 'Memory Disorders-associated-Leukoencephalopathies', 'Leukoencephalopathies-associated-Memory Disorders', 'Intervertebral Disc Degeneration-categorized-Fractures, Bone', 'Carotid Stenosis-associated-Ischemia', 'Ischemia-associated-Carotid Stenosis', 'Bone Marrow Diseases-progress-Leukemia, Myeloid, Acute', 'Carotid Artery Diseases-reduce-Ischemia', 'Carcinoma, Hepatocellular-include-Fibrosis', 'Carcinoma, Hepatocellular-underlie-Fibrosis', 'Sclerosis-associated-Neurodegenerative Diseases', 'Neurodegenerative Diseases-associated-Sclerosis', 'Neurodegenerative Diseases-accepted-Multiple Sclerosis', 'Esophageal Achalasia-referred-Neoplasm Invasiveness', 'Heart Block-compare-Pain', 'Infections-complicated-Bacteremia', 'Hypertrophy-related-Intervertebral Disc Degeneration', 'Esophageal Achalasia-undergo-Neoplasm Invasiveness', 'Acquired Immunodeficiency Syndrome-screened-Peripheral Nervous System Diseases', 'Peripheral Nervous System Diseases-defined-Hand-Arm Vibration Syndrome', 'Peripheral Nervous System Diseases-defined-Metatarsus Varus', 'Alzheimer Disease-assess-Dementia', 'Metabolic Syndrome-investigated-Obesity', 'Metabolic Syndrome-investigated-Metabolic Diseases', 'Hypogonadism-investigated-Obesity', 'Hypogonadism-investigated-Metabolic Diseases', 'Renal Insufficiency, Chronic-defined-Kidney Diseases', 'Femoral Fractures-associated-Bone Neoplasms', 'Bone Neoplasms-associated-Femoral Fractures', 'Femoral Fractures-associated-Osteoporosis', 'Osteoporosis-associated-Femoral Fractures', 'Femoral Fractures-associated-Arthritis', 'Arthritis-associated-Femoral Fractures', 'Hearing Loss-associated-Alzheimer Disease', 'Alzheimer Disease-associated-Hearing Loss', 'Fractures, Bone-sustain-Hyperalgesia', 'Femoral Fractures-associated-Bone Diseases, Metabolic', 'Bone Diseases, Metabolic-associated-Femoral Fractures', 'Femoral Fractures-associated-Contracture', 'Contracture-associated-Femoral Fractures', 'Obesity-control-Chronic Disease', 'Vascular Calcification-proposed-Coronary Artery Disease', 'Vascular Calcification-proposed-Hypotension', 'Tinnitus-fall-Cardiac Output, Low', 'Stroke-develop-Delirium', 'Wounds and Injuries-control-Hypotension', 'Delirium-associated-Stroke', 'Stroke-associated-Delirium', 'Delirium-occur-Stroke', 'Delirium-associated-Infections', 'Infections-associated-Delirium', 'Stroke-screened-Delirium', 'Infections-play-Neoplasms', 'Metabolic Syndrome-increase-Atrial Fibrillation', 'Carcinoma, Ductal-receive-Breast Neoplasms', 'Cardiovascular Diseases-induced-Hypertension', 'Leukoencephalopathies-related-Obesity', 'Leukoencephalopathies-related-Hypertension', 'Thyroid Cancer, Papillary-growing-Neoplasms', 'Neoplasms-used-Breast Neoplasms', 'Dyspnea-used-Infections', 'Heart Failure-cause-Urinary Bladder Neoplasms', 'Hepatitis B-investigated-Carcinoma, Hepatocellular', 'Hepatitis B-undergo-Carcinoma, Hepatocellular', 'Headache-report-Migraine Disorders', 'Alzheimer Disease-extended-Parkinson Disease', 'Headache-report-Headache Disorders, Secondary', 'Alzheimer Disease-extended-Dementia', 'Migraine Disorders-report-Headache Disorders, Secondary', 'Hernia-involve-Encephalocele', 'Hernia, Hiatal-involve-Encephalocele', 'Diabetes Mellitus-affected-Ulcer', 'Chronic Pain-related-Pain', 'Obesity-associated-Cerebral Hemorrhage', 'Cerebral Hemorrhage-associated-Obesity', 'Delirium-constitute-Dementia', 'Obesity-suggest-Infant, Premature, Diseases', 'Anemia, Aplastic-result-Death', 'Epilepsy-fail-Death', 'Memory Disorders-proposed-Alzheimer Disease', 'Fractures, Bone-require-Death', 'HIV Infections-characterized-Cerebrovascular Disorders', 'Hemangioma-known-Aneurysm', 'Nocturia-associated-Heart Diseases', 'Heart Diseases-associated-Nocturia', 'Myocardial Infarction-arrive-Pain', 'Acquired Immunodeficiency Syndrome-assessed-Death', 'HIV Infections-assessed-Death', 'Aneurysm-caused-Atherosclerosis', 'Erectile Dysfunction-associated-Prostatic Neoplasms', 'Prostatic Neoplasms-associated-Erectile Dysfunction', 'Wounds and Injuries-characterized-Subarachnoid Hemorrhage', 'Sleep Apnea, Obstructive-cover-Sleep Wake Disorders', 'Endometrial Neoplasms-relate-Obesity', 'Hematoma-include-Cerebrovascular Disorders', 'Endometrial Neoplasms-relate-Cardiac Output, Low', 'Subarachnoid Hemorrhage-include-Cerebrovascular Disorders', 'Renal Insufficiency, Chronic-derived-Proteinuria', 'Fractures, Bone-observed-Anemia', 'Metabolic Diseases-related-Obesity', 'Anemia, Iron-Deficiency-related-Hemorrhage', 'Kidney Failure, Chronic-appear-Death', 'Fractures, Bone-prevent-Heart Failure', 'Coronary Artery Disease-contribute-Cerebrovascular Disorders', 'Alzheimer Disease-prevent-Hip Fractures', 'Alzheimer Disease-undergo-Hip Fractures', 'Granulomatous Disease, Chronic-characterized-Primary Immunodeficiency Diseases', 'Granulomatous Disease, Chronic-impair-Genetic Diseases, Inborn', 'Infections-recognized-Granulomatous Disease, Chronic', 'Hypertension-recognized-Granulomatous Disease, Chronic', 'Arrhythmias, Cardiac-impact-Death', 'Primary Immunodeficiency Diseases-characterized-Inflammation', 'Primary Immunodeficiency Diseases-comprise-Genetic Diseases, Inborn', 'Primary Immunodeficiency Diseases-impair-Genetic Diseases, Inborn', 'Inflammation-comprise-Genetic Diseases, Inborn', 'Inflammation-impair-Genetic Diseases, Inborn', 'Arrhythmias, Cardiac-increase-Atrial Fibrillation', 'Neoplasms-determined-Colorectal Neoplasms', 'Carcinoma, Neuroendocrine-differ-Lung Neoplasms', 'Wounds and Injuries-vary-Hip Fractures', 'Neuralgia-represent-Skin Neoplasms', 'Pain-associated-Hyperuricemia', 'Hyperuricemia-associated-Pain', 'Endocarditis-remain-Death', 'Pain-disable-Joint Diseases', 'Arthritis-associated-Hyperuricemia', 'Hyperuricemia-associated-Arthritis', 'Arthritis-disable-Joint Diseases', 'Lymphomatoid Papulosis-associated-Neuralgia', 'Neuralgia-associated-Lymphomatoid Papulosis', 'Diabetes Mellitus-associated-Infarction', 'Infarction-associated-Diabetes Mellitus', 'Atrioventricular Block-dominate-Bradycardia', 'Cardiac Complexes, Premature-occur-Hypoxia', 'Death-affect-Infections', 'Cerebral Infarction-recruited-Stroke', 'Leukoaraiosis-associated-Cerebral Hemorrhage', 'Cerebral Hemorrhage-associated-Leukoaraiosis', 'Stroke-follow-Cerebral Infarction', 'Nervous System Diseases-incur-Brain Ischemia', 'Cerebrovascular Disorders-result-Neurologic Manifestations', 'Cerebrovascular Disorders-determined-Neurologic Manifestations', 'Cardiovascular Diseases-result-Neurologic Manifestations', 'Cardiovascular Diseases-determined-Neurologic Manifestations', 'Polyps-associated-Adenoma', 'Adenoma-associated-Polyps', 'Polyps-associated-Neoplasms', 'Neoplasms-associated-Polyps', 'Pulmonary Disease, Chronic Obstructive-characterized-Inflammation', 'Sleep Apnea, Obstructive-explain-Obesity', 'Obesity-explain-Cardiovascular Diseases', 'Chronic Pain-work-Memory Disorders', 'Alzheimer Disease-lead-Amnesia', 'Neurodegenerative Diseases-lead-Amnesia', 'Fractures, Bone-cause-Diabetes Mellitus', 'Dementia-carried-Alzheimer Disease', 'Thyroid Diseases-associated-Obesity', 'Obesity-associated-Thyroid Diseases', 'Death-readmitted-Heart Failure', 'Fractures, Bone-exposed-Death', 'Cardiac Output, Low-fall-Osteoporosis', 'Cardiac Output, Low-fall-Hypotension, Orthostatic', 'Cardiac Output, Low-fall-Urinary Incontinence', 'Nail Diseases-compare-Hip Fractures', 'Heart Failure, Diastolic-reported-Heart Failure', 'Osteoarthritis-see-Arthralgia', 'Hypertension-increase-Cardiovascular Diseases', 'Parkinson Disease-fall-Cardiac Output, Low', 'Death-observed-Metabolic Syndrome', 'Metabolic Syndrome-predict-Death', 'Diabetes Mellitus-contribute-Microvascular Angina', 'Microvascular Angina-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-Microvascular Angina', 'Death-associated-Memory Disorders', 'Memory Disorders-associated-Death', 'Progeria-exhibit-Cardiovascular Diseases', 'Progeria-cause-Death', 'Dyslipidemias-associated-Cerebrovascular Disorders', 'Cerebrovascular Disorders-associated-Dyslipidemias', 'Heart Failure-associated-Cerebrovascular Disorders', 'Cerebrovascular Disorders-associated-Heart Failure', 'Progeria-cause-Myocardial Infarction', 'Progeria-cause-Stroke', 'Death-compared-Neoplasms', 'Dementia-evaluate-Ischemia', 'Dementia-evaluate-Stroke', 'Death-cause-Myocardial Infarction', 'Death-cause-Stroke', 'Hypertension-treated-Stroke', 'Hypertension-treated-Myocardial Infarction', 'Hypertension-treated-Renal Insufficiency, Chronic', 'Hematoma, Subdural, Acute-impart-Death', 'Pulmonary Disease, Chronic Obstructive-known-Malnutrition', 'Proteinuria-associated-HIV Infections', 'HIV Infections-associated-Proteinuria', 'Hyperuricemia-increase-Cardiovascular Diseases', 'Diabetes Mellitus-accelerate-Dementia', 'Sleep Wake Disorders-reduce-Heart Failure', 'Stroke-include-Ischemia', 'Scoliosis-suggest-Pain', 'Atherosclerosis-suggest-Alzheimer Disease', 'Dementia-suggest-Alzheimer Disease', 'Skin Diseases-related-Diabetes Mellitus', 'Sclerosis-manifest-Aortic Aneurysm, Abdominal', 'Alzheimer Disease-extracted-Death', 'Dementia-extracted-Death', 'Heart Diseases-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-Heart Diseases', 'Heart Diseases-contribute-Brain Injuries', 'Cardiovascular Diseases-contribute-Brain Injuries', 'Cerebral Hemorrhage-include-Hemorrhage', 'Alzheimer Disease-reported-Death', 'Insulin Resistance-result-Diabetes Mellitus', 'Skin Diseases-associated-Heredodegenerative Disorders, Nervous System', 'Heredodegenerative Disorders, Nervous System-associated-Skin Diseases', 'Myoclonic Epilepsies, Progressive-charged-Heart Diseases', 'Myoclonic Epilepsies, Progressive-conduct-Heart Diseases', 'Non-alcoholic Fatty Liver Disease-consider-Cardiovascular Diseases', 'Skin Neoplasms-diagnosed-Neoplasms', 'Craniocerebral Trauma-consider-Wounds and Injuries', 'Fractures, Bone-initiate-Osteoporosis', 'Aortic Aneurysm, Abdominal-result-Death', 'Osteoarthritis-claimed-Musculoskeletal Pain', 'Lung Neoplasms-include-Neoplasms', 'Pancreatic Neoplasms-include-Neoplasms', 'Death-occur-Chronic Disease', 'Osteoarthritis-belong-Pain', 'Hearing Loss-hear-Diabetes Mellitus', 'Arrhythmias, Cardiac-occur-Tachycardia, Ventricular', 'Neoplasms-obtained-Glioma', 'Arrhythmias, Cardiac-occur-Tachycardia, Supraventricular', 'Arrhythmias, Cardiac-occur-Ventricular Fibrillation', 'Heterotaxy Syndrome-determine-Carcinoma, Skin Appendage', 'Neoplasms-impose-Death', 'Hypogonadism-defined-Headache Disorders, Secondary', 'Sleep Initiation and Maintenance Disorders-perform-Fatigue', 'Tuberculosis-followed-Death', 'Constipation-constipate-Alzheimer Disease', 'Arthralgia-prevent-Sleep Initiation and Maintenance Disorders', 'Metabolic Syndrome-associated-Erectile Dysfunction', 'Erectile Dysfunction-associated-Metabolic Syndrome', 'Metabolic Syndrome-associated-Hematologic Diseases', 'Hematologic Diseases-associated-Metabolic Syndrome', 'Delirium-suggest-Nerve Degeneration', 'Lymphangiectasis, Intestinal-associated-Angiodysplasia', 'Angiodysplasia-associated-Lymphangiectasis, Intestinal', 'Hypertension-increase-Hematuria', 'Delirium-experience-Metabolic Diseases', 'Heart Defects, Congenital-undergo-Endocarditis', 'Renal Insufficiency, Chronic-associated-Renal Insufficiency', 'Renal Insufficiency-associated-Renal Insufficiency, Chronic', 'Deglutition Disorders-present-Death', 'Hypogonadism-include-Metabolic Syndrome', 'Postpartum Hemorrhage-reduce-Death', 'Hip Fractures-decrease-Fractures, Bone', 'Osteoarthritis-avoid-Cardiac Output, Low', 'Neoplasms-rank-Breast Neoplasms', 'Breast Neoplasms-rank-Neoplasms', 'Breast Neoplasms-consider-Fatigue', 'Wounds and Injuries-cause-Neurologic Manifestations', 'Migraine Disorders-present-Headache', 'Dementia-include-Sleep Initiation and Maintenance Disorders', 'Staphylococcal Infections-predict-Death', 'Death-increase-Metabolic Syndrome', 'Osteoporosis-focus-Fractures, Bone', 'Femoral Neck Fractures-represent-Fractures, Bone', 'Obesity, Abdominal-impair-Dyslipidemias', 'Obesity, Abdominal-impair-Glucose Intolerance', 'Obesity, Abdominal-impair-Hypertension', 'Dyslipidemias-impair-Glucose Intolerance', 'Dyslipidemias-impair-Hypertension', 'Death-undergo-Aortic Valve Stenosis', 'Infections-introduce-Gastroenteritis', 'Vascular System Injuries-associated-Atherosclerosis', 'Atherosclerosis-associated-Vascular System Injuries', 'Heart Failure-present-Dyspnea', 'Vascular System Injuries-associated-Myocardial Infarction', 'Myocardial Infarction-associated-Vascular System Injuries', 'Vascular System Injuries-associated-Stroke', 'Stroke-associated-Vascular System Injuries', 'Arthritis, Rheumatoid-followed-Death', 'Inflammation-associated-Heart Failure', 'Heart Failure-associated-Inflammation', 'Upper Extremity Deformities, Congenital-associated-Lipodystrophy', 'Lipodystrophy-associated-Upper Extremity Deformities, Congenital', 'Pain-improve-Osteolysis', 'Breast Neoplasms-decrease-Death', 'Respiratory Tract Infections-associated-Infections', 'Infections-associated-Respiratory Tract Infections', 'Sclerosis-play-Atherosclerosis', 'Psychomotor Agitation-combined-Fever', 'Inflammation-play-Muscle Weakness', 'Death-undergo-Colonic Neoplasms', 'HIV Infections-manage-Hypertension', 'HIV Infections-manage-Diabetes Mellitus', 'Prostatic Hyperplasia-associated-Hypogonadism', 'Hypogonadism-associated-Prostatic Hyperplasia', 'Prostatic Hyperplasia-associated-Metabolic Syndrome', 'Metabolic Syndrome-associated-Prostatic Hyperplasia', 'Colonic Neoplasms-undergo-Colorectal Neoplasms', 'HIV Infections-receive-Communicable Diseases', 'Cerebrovascular Disorders-convey-Death', 'Sleep Apnea, Obstructive-show-Memory Disorders', 'Atrial Fibrillation-increasing-Cardiovascular Diseases', 'Seizures-associated-Weight Loss', 'Weight Loss-associated-Seizures', 'Drug Hypersensitivity-compared-Rhinitis, Allergic, Seasonal', 'Fractures, Bone-occur-Dementia', 'Fractures, Bone-occur-Respiratory Tract Diseases', 'Chronic Disease-predict-Death', 'Anemia-associate-Heart Failure', 'Heart Failure-associate-Anemia', 'Melanoma-regulate-Inflammation', 'Coronary Artery Disease-noted-Cardiovascular Diseases', 'Fractures, Bone-include-Osteoporosis', 'Fecal Incontinence-associated-Death', 'Death-associated-Fecal Incontinence', 'Hypoglycemia-associated-Sepsis', 'Sepsis-associated-Hypoglycemia', 'Hypoglycemia-associated-Pneumonia', 'Pneumonia-associated-Hypoglycemia', 'Heart Failure-result-Psychomotor Disorders', 'Musculoskeletal Diseases-associated-Neoplasms', 'Neoplasms-associated-Musculoskeletal Diseases', 'Musculoskeletal Diseases-associated-Death', 'Death-associated-Musculoskeletal Diseases', 'Infections-develop-Discitis', 'Constipation-improve-Chronic Disease', 'Multiple Myeloma-extracted-Neoplasms', 'Cholecystitis, Acute-undergo-Cholecystolithiasis', 'Polyps-undergo-Cholecystolithiasis', 'Neoplasms-undergo-Cholecystolithiasis', 'Anemia-affect-Renal Insufficiency', 'Kidney Diseases-affect-Renal Insufficiency', 'Neurodegenerative Diseases-contribute-Inflammation', 'Hemolysis-associated-Basal Ganglia Cerebrovascular Disease', 'Basal Ganglia Cerebrovascular Disease-associated-Hemolysis', 'Femoral Fractures-present-Fractures, Bone', 'Lupus Erythematosus, Systemic-associated-Atherosclerosis', 'Atherosclerosis-associated-Lupus Erythematosus, Systemic', 'Ossification of Posterior Longitudinal Ligament-associated-Dementia', 'Dementia-associated-Ossification of Posterior Longitudinal Ligament', 'Osteoarthritis-reveal-Diabetes Mellitus', 'Hypertension-established-Dementia', 'Hypertension-investigate-Dementia', 'Hypertension-predict-Dementia', 'Hypertension-predict-Memory Disorders', 'Constipation-increase-Tics', 'Hip Fractures-remain-Death', 'Hip Fractures-remain-Myocardial Infarction', 'Hip Fractures-remain-Venous Thromboembolism', 'Death-remain-Myocardial Infarction', 'Death-remain-Venous Thromboembolism', 'Heart Failure-accompany-Renal Insufficiency, Chronic', 'Coronary Artery Disease-i-Cerebral Infarction', 'Coronary Artery Disease-assessed-Atherosclerosis', 'Cerebral Infarction-assessed-Atherosclerosis', 'Atherosclerosis-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-Atherosclerosis', 'Polyarteritis Nodosa-include-Granulomatosis with Polyangiitis', 'Urinary Incontinence-select-Urinary Incontinence, Stress', 'Cardiac Output, Low-thought-Hip Fractures', 'Alzheimer Disease-assessed-Dementia', 'Bone Diseases, Metabolic-found-Fractures, Bone', 'Alzheimer Disease-affect-Dementia', 'Subarachnoid Hemorrhage-suggest-Cerebral Amyloid Angiopathy', 'Vision Disorders-associated-Hip Fractures', 'Hip Fractures-associated-Vision Disorders', 'Eye Diseases-associated-Hip Fractures', 'Hip Fractures-associated-Eye Diseases', 'Hepatitis C-increase-Death', 'Ischemia-induced-Pain', 'Muscle Weakness-identify-Peripheral Nervous System Diseases', 'Muscle Weakness-identify-Muscular Diseases', 'Hyperuricemia-encountered-Renal Insufficiency, Chronic', 'Infections-become-Cross Infection', 'Infections-result-Death', 'Cross Infection-result-Death', 'Renal Tubular Transport, Inborn Errors-characterized-Alzheimer Disease', 'Atrophy-predispose-Alzheimer Disease', 'Alzheimer Disease-correlate-Headache Disorders, Secondary', 'Polycythemia-associated-Hypoxia', 'Hypoxia-associated-Polycythemia', 'Polycythemia-associated-Obesity', 'Obesity-associated-Polycythemia', 'Status Epilepticus-diagnose-Epilepsy', 'Pulmonary Disease, Chronic Obstructive-result-Death', 'Pulmonary Disease, Chronic Obstructive-result-Hypertension', 'Kyphosis-equated-Osteoporosis', 'Memory Disorders-portend-Alzheimer Disease', 'Kyphosis-assumed-Fractures, Bone', 'Lordosis-equated-Osteoporosis', 'Lordosis-assumed-Fractures, Bone', 'Wounds and Injuries-query-Fractures, Bone', 'Osteoporosis-assumed-Fractures, Bone', 'Pulmonary Disease, Chronic Obstructive-included-Hypertension', 'Diabetes Mellitus, Type 2-enrol-Diabetes Mellitus', 'Headache Disorders, Secondary-increase-Neoplasms', 'Metabolic Syndrome-select-Inflammation', 'Dementia, Vascular-select-Inflammation', 'Hypopituitarism-attributed-Dwarfism, Pituitary', 'Atrial Fibrillation-seem-Obesity', 'Obesity-seem-Arrhythmias, Cardiac', 'Takotsubo Cardiomyopathy-used-Acute Coronary Syndrome', 'Heart Failure-publish-Death', 'Death-related-Aortic Aneurysm, Abdominal', 'Kidney Diseases-take-Seizures', 'Arthritis, Infectious-considered-Arthralgia', 'Arthritis, Infectious-considered-Edema', 'Myocardial Infarction-decrease-Death', 'Fractures, Bone-associated-Hip Fractures', 'Hip Fractures-associated-Fractures, Bone', 'Fractures, Bone-recruit-Hip Fractures', 'Delirium-occur-Hearing Loss', 'Diabetes Mellitus-include-Arthritis', 'Diabetes Mellitus-include-Heart Failure', 'Cyanosis-create-Arteriovenous Fistula', 'Spinal Cord Injuries-suffer-Neuralgia', 'Spinal Cord Diseases-examined-Delirium', 'Retinal Vein Occlusion-associated-Hypertension', 'Hypertension-associated-Retinal Vein Occlusion', 'Death-occur-Obesity', 'Retinal Vein Occlusion-associated-Glaucoma', 'Glaucoma-associated-Retinal Vein Occlusion', 'Erectile Dysfunction-explore-Diabetes Mellitus', 'Neurocysticercosis-present-Epilepsy', 'Kidney Diseases-reflect-Cerebral Small Vessel Diseases', 'Leukoencephalopathies-reflect-Cerebral Small Vessel Diseases', 'Fatty Liver-associated-Obesity, Abdominal', 'Obesity, Abdominal-associated-Fatty Liver', 'Cardiovascular Diseases-carry-Death', 'Metabolic Syndrome-associated-Aneurysm', 'Aneurysm-associated-Metabolic Syndrome', 'Renal Insufficiency, Chronic-recognized-Cardiovascular Diseases', 'Hyperhomocysteinemia-promote-Atherosclerosis', 'Pancreatitis-implicated-Diabetes Mellitus', 'Pneumonia-related-Fistula', 'Peritonitis, Tuberculous-followed-Infections', 'Infections-followed-Tuberculosis, Hepatic', 'Alzheimer Disease-contribute-Leukoencephalopathies', 'Infections-followed-Tuberculoma', 'Alzheimer Disease-enrolled-Cardiovascular Diseases', 'Vitamin K Deficiency-include-Osteoporosis', 'Vitamin K Deficiency-include-Vascular Calcification', 'Glaucoma-associated-Optic Nerve Diseases', 'Optic Nerve Diseases-associated-Glaucoma', 'Cerebral Hemorrhage-base-Stroke', 'Spinal Cord Injuries-modeled-Ossification of Posterior Longitudinal Ligament', 'Hemolytic-Uremic Syndrome-caused-Infections', 'Infections-develop-Hemolytic-Uremic Syndrome', 'Hypertension-provide-Death', 'Infections-participate-Foodborne Diseases', 'Hemolytic-Uremic Syndrome-participate-Foodborne Diseases', 'Cerebrovascular Disorders-include-Death', 'Syncope-receive-Hypotension, Orthostatic', 'Syncope-receive-Drug Hypersensitivity', 'Infections-improve-Stomach Neoplasms', 'Fibrosis-reflect-Heart Failure', 'Fibrosis-associated-Heart Failure', 'Heart Failure-associated-Fibrosis', 'Metabolic Syndrome-associated-Heart Failure', 'Heart Failure-associated-Metabolic Syndrome', 'Metabolic Syndrome-provide-Heart Failure', 'Inflammation-provide-Heart Failure', 'Death-account-Myocardial Infarction', 'Death-account-Cerebral Infarction', 'Sleep Wake Disorders-related-Cardiac Output, Low', 'Osteosarcoma-face-Bone Diseases', 'Venous Thrombosis-include-Wounds and Injuries', 'Venous Thrombosis-include-Neoplasms', 'Back Pain-become-Low Back Pain', 'Memory Disorders-detect-Dementia', 'Musculoskeletal Diseases-associated-Contracture', 'Contracture-associated-Musculoskeletal Diseases', 'Drug-Related Side Effects and Adverse Reactions-benefit-Small Cell Lung Carcinoma', 'Colitis, Ulcerative-reflect-Inflammatory Bowel Diseases', 'Atrophy-become-Neurodegenerative Diseases', 'Atrophy-become-Alzheimer Disease', 'von Willebrand Diseases-investigate-Aneurysm', 'von Willebrand Diseases-investigate-Coronary Artery Disease', 'von Willebrand Diseases-investigate-Stroke', 'Colitis-present-Diarrhea', 'von Willebrand Diseases-investigate-Dementia', 'Metabolic Syndrome-delineate-Death', 'Hypertension-delineate-Death', 'Cardiovascular Diseases-delineate-Death', 'Body Weight-delineate-Death', 'Neoplasms-delineate-Death', 'Arthritis, Rheumatoid-delineate-Death', 'Neurodegenerative Diseases-delineate-Death', 'Psychomotor Agitation-include-Genetic Diseases, Inborn', 'Tremor-associated-Dementia', 'Dementia-associated-Tremor', 'Pulmonary Disease, Chronic Obstructive-recommended-Hypercapnia', 'Atrial Fibrillation-recommend-Cerebral Infarction', 'Heart Diseases-diagnose-Pain', 'Adrenal Insufficiency-play-Dementia', 'Gastritis-associated-Infections', 'Infections-associated-Gastritis', 'Kidney Diseases-performed-Arteriovenous Fistula', 'Aortic Diseases-regarded-Aortic Valve Stenosis', 'Coronary Artery Disease-account-Cardiovascular Diseases', 'Hearing Disorders-perceive-Hearing Loss', 'Hearing Disorders-hear-Hearing Loss', 'Pain-reduce-Delirium', 'Parasomnias-characterized-Myalgia', 'Kidney Diseases-associated-Heart Failure', 'Heart Failure-associated-Kidney Diseases', 'Colorectal Neoplasms-analyzed-Neoplasms', 'Osteoporosis-found-Bone Diseases, Metabolic', 'Diverticulum-analyzed-Neoplasms', 'Alzheimer Disease-used-Dementia', 'Arthritis, Rheumatoid-diagnosed-Arthralgia', 'Arthritis, Rheumatoid-diagnosed-Pain', 'Hearing Loss-caused-Tinnitus', 'Arthritis-diagnosed-Arthralgia', 'Arthritis-diagnosed-Pain', 'Alzheimer Disease-arise-Movement Disorders', 'Myocardial Infarction-compared-Atrial Fibrillation', 'Cardiovascular Diseases-explain-Death', 'Inflammation-tend-Death', 'Alzheimer Disease-demonstrate-Stroke', 'Melanoma-arise-Neoplasms', 'Stroke-implicated-Alzheimer Disease', 'Diabetes Mellitus-caused-Hyperglycemia', 'Disease-caused-Hyperglycemia', 'Gastrointestinal Diseases-used-Abdominal Pain', 'Gastrointestinal Diseases-used-Hemorrhage', 'Diabetes Mellitus, Type 2-enrol-Hyperpigmentation', 'Cardiovascular Diseases-combined-Renal Insufficiency', 'Cardiovascular Diseases-combined-Pulmonary Disease, Chronic Obstructive', 'Cardiovascular Diseases-combined-Hypertension', 'Cardiovascular Diseases-combined-Cerebrovascular Disorders', 'Severe Acute Respiratory Syndrome-derived-Communicable Diseases', 'Carcinoma, Hepatocellular-receive-Neoplasms', 'Osteoporotic Fractures-recruited-Fractures, Bone', 'Glioblastoma-found-Neoplasms', 'Neoplasms-used-Glioblastoma', 'Neoplasms-identify-Glioblastoma', 'Dementia-enrol-Alzheimer Disease', 'Death-treated-Wounds and Injuries', 'Polyneuropathies-accompany-Pain', 'Ventricular Fibrillation-associated-Retinal Degeneration', 'Retinal Degeneration-associated-Ventricular Fibrillation', 'Ventricular Fibrillation-associated-Osteoarthritis', 'Osteoarthritis-associated-Ventricular Fibrillation', 'Pain-undetected-Dementia', 'Diabetes Mellitus-remain-Erectile Dysfunction', 'Intestinal Obstruction-occur-Cystic Fibrosis', 'Kyphosis-associated-Death', 'Death-associated-Kyphosis', 'Kyphosis-associated-Fractures, Bone', 'Fractures, Bone-associated-Kyphosis', 'Diabetes Mellitus, Type 2-include-Neurodegenerative Diseases', 'Atrophy-related-HIV Infections', 'Lung Neoplasms-result-Pleural Effusion, Malignant', 'Headache Disorders, Secondary-reported-Multiple Sclerosis', 'Headache-seen-Hypertension', 'Headache-seen-Diabetes Mellitus', 'Multiple Sclerosis-indicate-Headache Disorders, Secondary', 'Hallucinations-occur-Hearing Loss', 'Glucose Intolerance-determine-Hypertension', 'Diabetes Mellitus-determine-Hypertension', 'Acute Kidney Injury-present-Gastrointestinal Diseases', 'Sleepiness-suffer-Narcolepsy', 'Hallucinations-known-Parkinson Disease', 'Hypertension-determined-Stroke', 'Hypertension-determined-Hypercholesterolemia', 'Diabetes Mellitus-determined-Stroke', 'Diabetes Mellitus-determined-Hypercholesterolemia', 'Obesity-determined-Stroke', 'Spinal Cord Injuries-manifest-Cardiovascular Diseases', 'Obesity-determined-Hypercholesterolemia', 'Cerebrovascular Disorders-include-Cardiovascular Diseases', 'Peripheral Vascular Diseases-include-Cardiovascular Diseases', 'Irritable Bowel Syndrome-associated-Colonic Neoplasms', 'Colonic Neoplasms-associated-Irritable Bowel Syndrome', 'Sarcopenia-increase-Cardiovascular Diseases', 'Irritable Bowel Syndrome-associated-Lethargy', 'Lethargy-associated-Irritable Bowel Syndrome', 'Irritable Bowel Syndrome-associated-Back Pain', 'Back Pain-associated-Irritable Bowel Syndrome', 'Irritable Bowel Syndrome-associated-Chest Pain', 'Chest Pain-associated-Irritable Bowel Syndrome', 'Lethargy-include-Colonic Neoplasms', 'Back Pain-include-Colonic Neoplasms', 'Infections-associated-Carcinogenesis', 'Carcinogenesis-associated-Infections', 'Chest Pain-include-Colonic Neoplasms', 'Pain-investigate-Osteoarthritis', 'Death-reported-Neoplasms', 'Fasciitis, Necrotizing-carry-Death', "Hutchinson's Melanotic Freckle-assess-Melanoma", 'Leukoaraiosis-quantified-Cerebral Infarction', 'Peripheral Arterial Disease-associated-Fractures, Bone', 'Fractures, Bone-associated-Peripheral Arterial Disease', 'Learning Disabilities-develop-Dementia', 'Edema-related-Infections', 'Cardiac Output, Low-involve-Drug Hypersensitivity', 'Osteoarthritis-affect-Joint Diseases', 'Calcinosis-associated-Atherosclerosis', 'Atherosclerosis-associated-Calcinosis', 'Ocular Motility Disorders-prevent-Diarrhea', 'Syncope-refer-Unconsciousness', 'Hypotension-refer-Syncope', 'Hypotension, Orthostatic-refer-Unconsciousness', 'Hypotension, Orthostatic-caused-Unconsciousness', 'Hypotension-refer-Hypotension, Orthostatic', 'Hypotension-refer-Unconsciousness', 'Hypotension-caused-Unconsciousness', 'Neoplasms-associated-Immunologic Deficiency Syndromes', 'Immunologic Deficiency Syndromes-associated-Neoplasms', 'Arteritis-result-Vision Disorders', 'Vasculitis-result-Vision Disorders', 'Diabetes Mellitus-coexist-Hypotension', "Sjogren's Syndrome-associated-Headache Disorders, Secondary", "Headache Disorders, Secondary-associated-Sjogren's Syndrome", "Sjogren's Syndrome-associated-Dry Eye Syndromes", "Dry Eye Syndromes-associated-Sjogren's Syndrome", 'Ataxia Telangiectasia-characterized-Cerebellar Diseases', 'Heart Neoplasms-include-Stomach Neoplasms', 'Pneumonia-caused-Pneumococcal Infections', 'Trigeminal Neuralgia-lancinate-Facial Pain', 'Death-result-Infections', 'Pancreatitis-associated-Death', 'Death-associated-Pancreatitis', 'Atherosclerosis-associated-Brain Ischemia', 'Brain Ischemia-associated-Atherosclerosis', 'Dementia-compare-Osteoarthritis', 'Dementia-get-Osteoarthritis', 'Hypertension-recruit-Dementia', 'Aneurysm-complicated-Fractures, Bone', 'Death-estimate-Heart Failure', 'Death-use-Malocclusion', 'Radicular Cyst-cause-Kidney Diseases, Cystic', 'Deglutition Disorders-confirmed-Stroke', 'Osteoporosis-protect-Pulmonary Disease, Chronic Obstructive', 'Lung Diseases-show-Emphysematous Cholecystitis', 'Sleep Wake Disorders-confirm-Sleep Apnea, Obstructive', 'Hypertension-protect-Pulmonary Disease, Chronic Obstructive', 'Diabetes Mellitus-protect-Pulmonary Disease, Chronic Obstructive', 'Infections-protect-Pulmonary Disease, Chronic Obstructive', 'Hemophilia A-compared-Hemorrhage', 'Sarcoidosis-show-Neoplasms', 'Neoplasms-noted-Sarcoidosis', 'Aging, Premature-manifest-Infertility, Female', 'Death-followed-Diabetes Mellitus', 'Chronic Disease-deserve-Kidney Failure, Chronic', 'Diabetes Mellitus-respond-Ischemia', 'Infections-consider-Coronary Artery Disease', 'Myocardial Infarction-stratified-Angina, Unstable', 'Angina, Unstable-confer-Death', 'Angina, Unstable-confer-Myocardial Infarction', 'Ischemia-confer-Death', 'Ischemia-confer-Myocardial Infarction', 'Neuroendocrine Tumors-vary-Neoplasms', 'Neoplasms-vary-Neuroendocrine Tumors', 'Cardiovascular Diseases-involve-Obesity', 'Erectile Dysfunction-involve-Cardiovascular Diseases', 'Aortic Valve Stenosis-considered-Atherosclerosis', 'Skin Neoplasms-include-Erythema', 'Osteoporosis-caused-Bone Neoplasms', 'Hypoalphalipoproteinemias-associated-Dementia', 'Dementia-associated-Hypoalphalipoproteinemias', 'Stroke-suffer-Carotid Artery Thrombosis', 'Stroke-develop-Hypertension', 'Hypertension-identified-Stroke', 'Hypertension-identified-Cerebral Infarction', 'Fasciitis, Necrotizing-result-Death', 'Disease Progression-result-Death', 'Hip Fractures-result-Cardiac Output, Low', 'Infections-appear-Prostatic Neoplasms', 'Thrombophilia-appear-Pneumoperitoneum', 'Pneumoperitoneum-make-Venous Thrombosis', 'Coma-become-Drug Overdose', 'Prostatic Neoplasms-demonstrated-Neoplasms', 'Prostatic Neoplasms-demonstrated-Carcinoma, Merkel Cell', 'Acute Kidney Injury-associated-HIV Infections', 'HIV Infections-associated-Acute Kidney Injury', 'Diabetes Mellitus-associated-Neurologic Manifestations', 'Neurologic Manifestations-associated-Diabetes Mellitus', 'Brain Infarction-associated-Neurologic Manifestations', 'Neurologic Manifestations-associated-Brain Infarction', 'Hernia-report-Weight Gain', 'Hernia-obtained-Weight Gain', 'Hypotension-result-Syncope', 'Hypotension-lead-Syncope', 'Hypotension-result-Muscle Weakness', 'Hypotension-lead-Muscle Weakness', 'Hypotension-result-Angina Pectoris', 'Hypotension-lead-Angina Pectoris', 'Cardiovascular Diseases-diagnosed-Death', 'Hypotension-result-Stroke', 'Hypotension-lead-Stroke', 'Tuberculosis-reported-Death', 'Stroke-compared-Atrial Fibrillation', 'Erectile Dysfunction-report-Sexual Dysfunction, Physiological', 'Colorectal Neoplasms-recruited-Neoplasms', 'Stroke-stratify-Atrial Fibrillation', 'Mitochondrial Diseases-contribute-Sarcopenia', 'Dementia-precede-Weight Loss', 'Unconsciousness-refer-Syncope', 'Dementia-include-Substance-Related Disorders', 'Delirium-include-Substance-Related Disorders', 'Breast Neoplasms-consist-Lymphedema', 'Death-undergo-Lung Neoplasms', 'Breast Neoplasms-consist-Neoplasms', 'Neoplasms-consist-Lymphedema', 'Lung Neoplasms-treated-Death', 'Pain-include-Dementia', 'Pulmonary Embolism-tolerate-Hemorrhage', 'Hearing Loss, Central-caused-Nephritis, Hereditary', 'Hearing Loss-caused-Nephritis, Hereditary', 'Emphysema-exhibit-Werner Syndrome', 'Salmonella Infections-cause-Gastroenteritis', 'Werner Syndrome-compare-Emphysema', 'Death-use-Sleep Deprivation', 'Neoplasms-identify-Alcoholism', 'Stroke-manifested-Paresis', 'Neoplasms-lead-Infertility, Female', 'Inflammation-promote-Brain Injuries, Diffuse', 'Inflammation-promote-Stroke', 'Colorectal Neoplasms-elevated-Colitis, Ulcerative', 'Alzheimer Disease-include-Diabetes Mellitus', 'Alzheimer Disease-include-Hypertension', 'Hypertension-reduce-Heart Failure', 'Fractures, Bone-registered-Hip Fractures', 'Inflammation-emerge-Amyotrophic Lateral Sclerosis', 'Arthritis-include-Chronic Disease', 'Osteoarthritis-manifested-Pain', 'Neurodegenerative Diseases-manifested-Pain', 'Hypoglycemia-collected-Diabetes Mellitus', 'Anemia-contribute-Death', 'Dementia-mediated-Sarcopenia', 'Kidney Failure, Chronic-associated-Metabolic Syndrome', 'Metabolic Syndrome-associated-Kidney Failure, Chronic', 'Sleep Apnea, Obstructive-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-Sleep Apnea, Obstructive', 'Sleep Apnea, Obstructive-mediate-Atherosclerosis', 'Renal Insufficiency, Chronic-use-Kidney Diseases', 'Cardiovascular Diseases-mediate-Atherosclerosis', 'Anemia-related-Death', 'Osteoarthritis-develop-Obesity', 'Fractures, Stress-considered-Low Back Pain', 'Neurologic Manifestations-associated-Intracranial Hemorrhages', 'Intracranial Hemorrhages-associated-Neurologic Manifestations', 'Hypotension-associated-Intracranial Hemorrhages', 'Intracranial Hemorrhages-associated-Hypotension', 'Takotsubo Cardiomyopathy-offered-Aortic Valve Stenosis', 'Carcinoma, Hepatocellular-diagnosed-Chemical and Drug Induced Liver Injury', 'Low Back Pain-compared-Pain', 'X-Linked Combined Immunodeficiency Diseases-link-Sleep Initiation and Maintenance Disorders', 'Infections-observed-Hematologic Neoplasms', 'Hypothalamic Neoplasms-suggested-Coronary Artery Disease', 'Brain Diseases-characterized-Seizures', 'Stomatitis-investigated-Cleft Palate', 'Mouth Diseases-investigated-Cleft Palate', 'Acute Kidney Injury-associated-Liver Failure, Acute', 'Liver Failure, Acute-associated-Acute Kidney Injury', 'Parkinson Disease-associate-Vestibular Diseases', 'Vestibular Diseases-associate-Parkinson Disease', 'Hallucinations-cause-Vision Disorders', 'Vision Disorders-associated-Hallucinations', 'Hallucinations-associated-Vision Disorders', 'Vision Disorders-act-Hallucinations', 'Hearing Loss, Central-investigate-Cerebral Infarction', 'Metabolic Diseases-result-Galactosemias', 'Carcinoma, Hepatocellular-correlate-Liver Cirrhosis', 'Hepatitis C-correlate-Liver Cirrhosis', 'Acute Kidney Injury-carry-Kidney Diseases', 'Urinary Incontinence-linked-Obesity', 'Obesity-associated-Urinary Incontinence', 'Urinary Incontinence-associated-Obesity', 'Tuberculosis, Pulmonary-differ-Signs and Symptoms, Respiratory', 'Seizures-associated-Alzheimer Disease', 'Alzheimer Disease-associated-Seizures', 'Hypotension-include-Prediabetic State', 'Metabolic Syndrome-considered-Atherosclerosis', 'Seizures-reduced-Alzheimer Disease', 'Seizures-reduced-Dementia', 'Chemical and Drug Induced Liver Injury-tested-Hepatitis E', 'Chemical and Drug Induced Liver Injury-followed-Death', 'Hepatitis E-followed-Death', 'Huntington Disease-associated-Arteriovenous Fistula', 'Arteriovenous Fistula-associated-Huntington Disease', 'Scleroderma, Systemic-undergo-Pulmonary Arterial Hypertension', 'Inflammation-accompany-Osteoarthritis', 'Hip Fractures-result-Wounds and Injuries', 'Fractures, Bone-related-Neoplasm Metastasis', 'Fractures, Bone-related-Multiple Myeloma', 'Myocardial Infarction-associated-Ventricular Remodeling', 'Ventricular Remodeling-associated-Myocardial Infarction', 'Pain-suffer-Osteoarthritis', 'Osteoporosis-result-Pain', 'Osteoporosis-result-Musculoskeletal Diseases', 'Cerebral Infarction-identified-Death', 'Delirium-occur-Neoplasms', 'Gastrointestinal Hemorrhage-associated-Death', 'Death-associated-Gastrointestinal Hemorrhage', 'Colorectal Neoplasms-place-Neoplasms', 'Neoplasms-place-Colorectal Neoplasms', 'Colitis-associated-Diverticular Diseases', 'Diverticular Diseases-associated-Colitis', 'Thrombosis-include-Ischemia', 'Death-admitted-Pancreatitis', 'Asthenia-diagnosed-Neoplasms', 'Osteoporosis-fall-Fractures, Bone', 'Arrhythmogenic Right Ventricular Dysplasia-associated-Death, Sudden', 'Death, Sudden-associated-Arrhythmogenic Right Ventricular Dysplasia', 'Arrhythmogenic Right Ventricular Dysplasia-associated-Heart Failure', 'Heart Failure-associated-Arrhythmogenic Right Ventricular Dysplasia', 'Heart Diseases-moderate-Stroke', 'Memory Disorders-detect-Alzheimer Disease', 'Stroke-sustain-Wounds and Injuries', 'Stroke-sustain-Fractures, Bone', 'Wounds and Injuries-sustain-Fractures, Bone', 'Atrial Fibrillation-estimated-Stroke', 'Inflammation-associate-Gallstones', 'Gallstones-associate-Inflammation', 'Atrial Fibrillation-estimated-Cerebral Infarction', 'Neoplasms-study-Carcinoma, Non-Small-Cell Lung', 'Death-increase-Coronary Artery Disease', 'Death-hospitalized-Heart Failure', 'Fatigue-recognized-Rheumatic Diseases', 'Hypoxia-influence-Neoplasms', 'Fatigue-recognized-Arthritis, Rheumatoid', 'Fatigue-recognized-Lupus Erythematosus, Systemic', 'Delirium-shown-Death', 'Vision Disorders-predict-Death', 'Eye Diseases-shown-Birdshot Chorioretinopathy', 'Eye Diseases-shown-Endophthalmitis', 'Autoimmune Diseases-shown-Birdshot Chorioretinopathy', 'Autoimmune Diseases-shown-Endophthalmitis', 'Heart Septal Defects, Atrial-prevent-Heart Failure', 'Death-remain-Heart Failure', 'Peptic Ulcer-affect-Hemorrhage', 'Obesity-clarify-Death', 'Diabetes Mellitus-use-Sleep Initiation and Maintenance Disorders', 'Cardiovascular Diseases-increased-Renal Insufficiency, Chronic', 'Drug-Related Side Effects and Adverse Reactions-occur-Anorexia', 'Drug-Related Side Effects and Adverse Reactions-occur-Nausea', 'Drug-Related Side Effects and Adverse Reactions-occur-Vomiting', 'Drug-Related Side Effects and Adverse Reactions-occur-Diarrhea', 'Drug-Related Side Effects and Adverse Reactions-occur-Stomatitis', 'Pulmonary Disease, Chronic Obstructive-associated-Respiratory Tract Infections', 'Respiratory Tract Infections-associated-Pulmonary Disease, Chronic Obstructive', 'Drug-Related Side Effects and Adverse Reactions-occur-Pain Insensitivity, Congenital', 'Drug-Related Side Effects and Adverse Reactions-occur-Motor Neuron Disease', 'Drug-Related Side Effects and Adverse Reactions-occur-Dyspnea', 'Drug-Related Side Effects and Adverse Reactions-occur-Hyperglycemia', 'Infertility, Female-presented-Primary Ovarian Insufficiency', 'Infertility, Female-present-Primary Ovarian Insufficiency', 'Drug-Related Side Effects and Adverse Reactions-occur-Infections', 'Hypercholesterolemia-found-Hypertension', 'Periodontitis-suggest-Coronary Artery Disease', 'Jaw Diseases-include-Parkinson Disease, Secondary', 'Chronic Periodontitis-associated-Coronary Artery Disease', 'Coronary Artery Disease-associated-Chronic Periodontitis', 'Diabetes Mellitus-observed-Heart Failure', 'Anemia-associated-Muscle Weakness', 'Muscle Weakness-associated-Anemia', 'Stroke-extract-Myocardial Infarction', 'Hip Fractures-extract-Myocardial Infarction', 'Gastrointestinal Hemorrhage-extract-Myocardial Infarction', 'Heart Failure-extract-Myocardial Infarction', 'Anemia-associated-Cardiac Output, Low', 'Cardiac Output, Low-associated-Anemia', 'Pneumonia-extract-Myocardial Infarction', 'Death-dissipate-Leishmaniasis, Visceral', 'Hypertension-related-Alzheimer Disease', 'Heart Diseases-related-Alzheimer Disease', 'Stroke-related-Alzheimer Disease', 'Testicular Neoplasms-analyzed-Neoplasms', 'Testicular Neoplasms-analyzed-Seminoma', 'Death-increase-Shock, Septic', 'Testicular Neoplasms-treated-Neoplasms', 'Death-increase-Multiple Organ Failure', 'Hypertension-increase-Stroke', 'Heart Failure-raise-Death', 'Brain Injuries, Traumatic-carry-Death', 'Spinal Cord Injuries-carry-Death', 'Headache-seen-Stroke', 'Heart Failure-caused-Ventricular Dysfunction', 'Osteoporosis-reach-Hip Fractures', 'Headache-reveal-Intracranial Hemorrhages', 'Hip Fractures-facilitate-Osteoporosis', 'Osteolysis-increase-Fractures, Bone', 'Osteolysis-complicate-Bone Neoplasms', 'Fractures, Bone-required-Osteoporosis', 'Fractures, Bone-complicate-Bone Neoplasms', 'Metabolic Syndrome-associate-Cardiovascular Diseases', 'Cardiovascular Diseases-associate-Metabolic Syndrome', 'Hip Fractures-required-Osteoporosis', 'Erectile Dysfunction-associated-Communicable Diseases', 'Communicable Diseases-associated-Erectile Dysfunction', 'Familial Primary Pulmonary Hypertension-culminate-Ventricular Dysfunction, Right', 'Familial Primary Pulmonary Hypertension-culminate-Death', 'Disease Progression-culminate-Ventricular Dysfunction, Right', 'Disease Progression-culminate-Death', 'Glucose Metabolism Disorders-associated-Death', 'Death-associated-Glucose Metabolism Disorders', 'Glucose Metabolism Disorders-associated-Dementia', 'Dementia-associated-Glucose Metabolism Disorders', 'Hemochromatosis-associated-Kyphosis', 'Kyphosis-associated-Hemochromatosis', 'Hemochromatosis-associated-Obesity', 'Obesity-associated-Hemochromatosis', 'Brain Diseases-associated-Heart Diseases', 'Heart Diseases-associated-Brain Diseases', 'Leukoencephalopathies-associated-Heart Diseases', 'Heart Diseases-associated-Leukoencephalopathies', 'Heart Failure, Diastolic-defined-Heart Failure', 'Heart Failure, Diastolic-defined-Heart Valve Diseases', 'Hypotension-made-Atrial Fibrillation', 'Heart Failure-defined-Heart Valve Diseases', 'Progeria-lead-Death', 'Progeria-lead-Myocardial Infarction', 'Progeria-lead-Stroke', 'Genetic Diseases, Inborn-involve-Death', 'Genetic Diseases, Inborn-involve-Myocardial Infarction', 'Genetic Diseases, Inborn-lead-Myocardial Infarction', 'Contracture-documented-Cardiovascular Diseases', 'Aneurysm-associated-Acute Kidney Injury', 'Acute Kidney Injury-associated-Aneurysm', 'Genetic Diseases, Inborn-involve-Stroke', 'Genetic Diseases, Inborn-lead-Stroke', 'Bone Diseases-documented-Cardiovascular Diseases', 'Cushing Syndrome-associated-Muscle Weakness', 'Muscle Weakness-associated-Cushing Syndrome', 'Oculocerebrorenal Syndrome-cause-Fractures, Bone', 'Wounds and Injuries-used-Hip Fractures', 'Wounds and Injuries-present-Hip Fractures', 'Tuberculosis, Pulmonary-cause-Death', 'Atrophy-harbor-Alzheimer Disease', 'Tooth Loss-associated-Death', 'Death-associated-Tooth Loss', 'Tooth Loss-follow-Death', 'Mitral Valve Stenosis-documented-Ventricular Fibrillation', 'Cerebral Palsy-include-Musculoskeletal Diseases', 'Death-related-Tuberculosis', 'Dementia-suggested-Genetic Diseases, Inborn', 'Atherosclerosis-include-Hypertension', 'Atherosclerosis-include-Diabetes Mellitus', 'Atherosclerosis-include-Dyslipidemias', 'Atherosclerosis-include-Obesity', 'Muscular Diseases-induced-Hyponatremia', 'Alzheimer Disease-screen-Malnutrition', 'Fibrosis-prevent-Liver Failure', 'Renal Insufficiency-recognized-Death', 'Wounds and Injuries-removed-Neoplasms', 'Neck Injuries-treated-Wounds and Injuries', 'Wounds and Injuries-removed-Infections', 'Wounds and Injuries-removed-Eye Pain', 'Neoplasms-removed-Eye Pain', 'Infections-removed-Eye Pain', 'Olfaction Disorders-associated-Parkinson Disease', 'Parkinson Disease-associated-Olfaction Disorders', 'Femoral Fractures-related-Osteoporosis', 'Hypertension-relate-Alzheimer Disease', 'Gastritis-show-Stomach Neoplasms', 'Hip Fractures-affect-Death', 'Osteoarthritis-suffered-Osteoporosis', 'Intervertebral Disc Degeneration-precede-Neurodegenerative Diseases', 'Atherosclerosis-characterized-Pain', 'Atherosclerosis-characterized-Limb Deformities, Congenital', 'Angina, Unstable-play-Coronary Stenosis', 'Erectile Dysfunction-recognized-Cardiovascular Diseases', 'Chronic Disease-related-Obesity', 'Cardiovascular Diseases-include-Erectile Dysfunction', 'Hypertension-include-Erectile Dysfunction', 'Dyslipidemias-include-Erectile Dysfunction', 'Cardiovascular Diseases-identify-Dyslipidemias', 'Epilepsy-screened-Sleep Wake Disorders', 'Sleep Wake Disorders-coexist-Epilepsy', 'Urinary Incontinence-undergo-Weight Loss', 'Fecal Incontinence-undergo-Weight Loss', 'Obesity-undergo-Weight Loss', 'Genetic Diseases, Inborn-identified-Neoplasms', 'Genetic Diseases, Inborn-identified-Colorectal Neoplasms', 'Genetic Diseases, Inborn-identified-Hematologic Neoplasms', 'Hypotension, Orthostatic-associated-Cerebrovascular Disorders', 'Cerebrovascular Disorders-associated-Hypotension, Orthostatic', 'Atherosclerosis-associated-Dementia', 'Dementia-associated-Atherosclerosis', 'Atherosclerosis-associated-Dementia, Vascular', 'Dementia, Vascular-associated-Atherosclerosis', 'Infarction-increase-Cardiomyopathies', 'Infarction-increase-Heart Diseases', 'Lordosis-measured-Spondylolysis', 'Stroke-assess-Atrial Fibrillation', 'Stroke-cause-Atrial Fibrillation', 'Pain-noted-Brucellosis', 'Inflammation-play-Demyelinating Diseases', 'Inflammation-play-Multiple Sclerosis', 'Fever-noted-Brucellosis', 'Alzheimer Disease-improve-Psychoses, Substance-Induced', 'Renal Insufficiency, Chronic-increase-Hypertension', 'Inflammation-play-Chronic Disease', 'Cardiac Output, Low-represent-Fatigue', 'Stroke-limit-Hemorrhage', 'Atrial Fibrillation-analyzed-Stroke', 'Atrial Fibrillation-limit-Hemorrhage', 'Atrial Fibrillation-randomized-Stroke', 'Atrial Fibrillation-analyzed-Hemorrhage', 'Stroke-analyzed-Hemorrhage', 'Cerebral Infarction-target-Dementia', 'Fractures, Bone-lessen-Osteoporosis', 'Blood Coagulation Disorders-associated-Thrombosis', 'Thrombosis-associated-Blood Coagulation Disorders', 'Dyskinesia, Drug-Induced-associated-Brain Diseases', 'Brain Diseases-associated-Dyskinesia, Drug-Induced', 'Pain-affect-Osteoarthritis', 'Neoplasms-defined-Colorectal Neoplasms', 'Alzheimer Disease-observed-Dementia', 'Neoplasms-defined-Adenoma', 'Alzheimer Disease-observed-Dementia, Vascular', 'Anemia-classify-Death', 'Muscular Dystrophy, Duchenne-predict-Fractures, Bone', 'Thrombosis-associated-Venous Thromboembolism', 'Venous Thromboembolism-associated-Thrombosis', 'Inflammation-followed-Hemorrhage', 'Inflammation-followed-Choledocholithiasis', 'Inflammation-followed-Gallbladder Neoplasms', 'Inflammation-followed-Cholestasis', 'Inflammation-followed-Gallstones', 'Neuralgia-occur-Infections', 'Neuralgia-follow-Infections', 'Muscular Atrophy-associated-Fractures, Bone', 'Fractures, Bone-associated-Muscular Atrophy', 'Stroke-decreasing-Death', 'Death-targeted-Stroke', 'Pneumatosis Cystoides Intestinalis-indicate-Ischemia', 'Pleural Effusion-diagnosed-Death', 'Empyema-diagnosed-Death', 'Death-triggered-Carcinoma, Hepatocellular', 'Memory Disorders-evolve-Dementia', 'Memory Disorders-meet-Alzheimer Disease', 'Dementia-meet-Alzheimer Disease', 'Neoplasms-associated-Cardiac Output, Low', 'Cardiac Output, Low-associated-Neoplasms', 'Neoplasms-decrease-Cardiac Output, Low', 'Ulcer-include-Stomach Diseases', 'Stroke-precede-Cerebral Infarction', 'Neoplasms-identify-Central Nervous System Neoplasms', 'Bacteremia-complicated-Infections', 'Gastroesophageal Reflux-include-Stomatognathic Diseases', 'Pain-relieve-Osteoarthritis, Hip', 'Metabolic Syndrome-related-Alzheimer Disease', 'Scoliosis-associated-Constriction, Pathologic', 'Constriction, Pathologic-associated-Scoliosis', 'Carcinoma, Squamous Cell-undergo-Neoplasms', 'Hemangiosarcoma-undergo-Neoplasms', 'Headache Disorders, Secondary-associated-Substance-Related Disorders', 'Substance-Related Disorders-associated-Headache Disorders, Secondary', 'Hernia-associated-Death', 'Death-associated-Hernia', 'Short Bowel Syndrome-associated-Death', 'Death-associated-Short Bowel Syndrome', 'Leukoaraiosis-regarded-Stroke', 'Hypotension, Orthostatic-occur-Alzheimer Disease', 'Stomach Neoplasms-associated-Head and Neck Neoplasms', 'Head and Neck Neoplasms-associated-Stomach Neoplasms', 'Aneurysm-associated-Head and Neck Neoplasms', 'Head and Neck Neoplasms-associated-Aneurysm', 'Kidney Diseases-treated-Hypertension', 'Nervous System Diseases-compare-Hypertension', 'Peripheral Nervous System Diseases-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-Peripheral Nervous System Diseases', 'Chronic Disease-result-Death', 'Colorectal Neoplasms-associated-Osteoarthritis', 'Osteoarthritis-associated-Colorectal Neoplasms', 'Heart Failure, Diastolic-increasing-Hypotension', 'Cytomegalovirus Infections-result-Communicable Diseases', 'Cytomegalovirus Infections-result-Death', 'Kidney Diseases-considered-Hyperkalemia', 'Diabetes Mellitus-considered-Hyperkalemia', 'Obesity-become-Hypertension', 'Obesity-become-Diabetes Mellitus', 'Obesity-become-Dyslipidemias', 'Neoplasms-undergo-Neoplasm Invasiveness', 'Sleep Initiation and Maintenance Disorders-defined-Death', 'Cardiovascular Diseases-occur-Spinal Cord Injuries', 'Dementia-function-Cardiovascular Diseases', 'Carcinoma, Hepatocellular-defined-Chemical and Drug Induced Liver Injury', 'Metabolic Diseases-increase-Cardiovascular Diseases', 'Metabolic Diseases-increase-Diabetes Mellitus', 'Osteoarthritis-participate-Arthritis', 'Osteoarthritis-participate-Rheumatic Diseases', 'Arthritis, Rheumatoid-participate-Arthritis', 'Arthritis, Rheumatoid-participate-Rheumatic Diseases', 'Delirium-discriminated-Dementia', 'Infarction-increase-Dementia', 'Diabetes Mellitus-assess-Death', 'Alzheimer Disease-Examine-Infarction', 'Dementia-Examine-Infarction', 'Hepatitis E-thought-Zoonoses', 'Lung Neoplasms-extrapolated-Drug-Related Side Effects and Adverse Reactions', 'Spinal Cord Injuries-enrolled-Spinal Injuries', 'Neoplasm Metastasis-associated-Death', 'Death-associated-Neoplasm Metastasis', 'Spinal Cord Injuries-associated-Aortic Aneurysm', 'Aortic Aneurysm-associated-Spinal Cord Injuries', 'Blind Loop Syndrome-occur-Achlorhydria', 'Blind Loop Syndrome-accompany-Parkinson Disease', 'Cerebrovascular Disorders-represent-Dementia', 'Stroke-rank-Death', 'Carotid Stenosis-include-Stroke', 'Atherosclerosis-include-Stroke', 'Peripheral Vascular Diseases-include-Stroke', 'Cardiomyopathies-followed-Ventricular Remodeling', 'Cardiomyopathies-followed-Heart Failure', 'Tooth, Impacted-impact-Malnutrition', 'Leukoaraiosis-correlate-Hypertension', 'Myocardial Infarction-associated-Coronary Artery Disease', 'Coronary Artery Disease-associated-Myocardial Infarction', 'Death-associated-Angina Pectoris', 'Angina Pectoris-associated-Death', 'Myocardial Infarction-show-Death', 'Calcinosis-associated-Coronary Artery Disease', 'Coronary Artery Disease-associated-Calcinosis', 'Calcinosis-associated-Plaque, Atherosclerotic', 'Plaque, Atherosclerotic-associated-Calcinosis', 'Calcinosis-observed-Plaque, Atherosclerotic', 'Gallstones-coded-Malocclusion', 'Neurodegenerative Diseases-occur-Dementia', 'Anorexia-increase-Death', 'Stroke-investigated-Cerebral Infarction', 'Dementia-investigated-Cerebral Infarction', 'Aphasia-distinguish-Frontotemporal Lobar Degeneration', 'Aphasia-distinguish-Alzheimer Disease', 'Frontotemporal Lobar Degeneration-compared-Alzheimer Disease', 'Diabetes Mellitus-occur-Death', 'HIV Infections-report-Hemorrhage', 'Atherosclerosis-induced-Hypertension', 'Alzheimer Disease-distinguish-Frontotemporal Lobar Degeneration', 'Tachypnea-associated-Cartilage Diseases', 'Cartilage Diseases-associated-Tachypnea', 'Tachypnea-cause-Cartilage Diseases', 'Subarachnoid Hemorrhage-investigated-Stroke', 'Subarachnoid Hemorrhage-use-Stroke', 'Obesity-associated-Breast Neoplasms', 'Breast Neoplasms-associated-Obesity', 'Death-include-Neoplasms', 'Death-compared-Fractures, Bone', 'Death-include-Fractures, Bone', 'Death-compared-Heart Failure', 'Death-compared-Stroke', 'Death-include-Stroke', 'Eye Diseases-remain-Pituitary Neoplasms', 'Fat Necrosis-associated-HIV Infections', 'HIV Infections-associated-Fat Necrosis', 'Movement Disorders-searched-Myoclonus', 'Movement Disorders-diagnosed-Myoclonus', 'Neurodegenerative Diseases-result-Pain', 'Chronic Disease-result-Pain', 'Diabetes Mellitus-affected-Hypertension', 'Obesity-increase-Chronic Disease', 'Memory Disorders-associated-Dementia', 'Dementia-associated-Memory Disorders', 'Hypertension-confer-Atrial Fibrillation', 'Vision Disorders-result-Cataract', 'Headache Disorders, Secondary-related-Urinary Incontinence', 'Arthritis-live-Pain', 'Muscular Diseases-associated-Fatigue', 'Fatigue-associated-Muscular Diseases', 'Primary Ovarian Insufficiency-affect-Infertility, Female', 'Hematoma, Subdural-reported-Death', 'Leukoencephalopathies-increased-Dementia, Vascular', 'Dementia, Vascular-compare-Alzheimer Disease', 'Leukoencephalopathies-compare-Alzheimer Disease', 'Hip Fractures-associated-Osteoporosis', 'Osteoporosis-associated-Hip Fractures', 'Neoplasms-diagnosed-Skin Neoplasms', 'Neoplasms-exclude-Skin Neoplasms', 'Skin Neoplasms-exclude-Death', 'Fractures, Bone-categorized-Fractures, Stress', 'Deglutition Disorders-fed-Dehydration', 'Pulmonary Disease, Chronic Obstructive-diagnose-Headache Disorders, Secondary', 'Fractures, Bone-experience-Pain', 'Atrial Fibrillation-cause-Heart Failure', 'Fractures, Stress-undergo-Death', 'Intestinal Atresia-associated-Death', 'Death-associated-Intestinal Atresia', 'Cardiovascular Diseases-reflected-Death', 'Cardiovascular Diseases-worsen-Death', 'Death-examine-Pulmonary Disease, Chronic Obstructive', 'Wounds and Injuries-overlooked-Fractures, Bone', 'Intracranial Hemorrhages-overlooked-Fractures, Bone', 'Wounds and Injuries-query-Intracranial Hemorrhages', 'Wounds and Injuries-show-Intracranial Hemorrhages', 'Neurologic Manifestations-overlooked-Fractures, Bone', 'Arrhythmias, Cardiac-prevent-Thromboembolism', 'Aneurysm-fail-Ischemia', 'Neoplasms-diagnosed-Carcinoma, Non-Small-Cell Lung', 'Sleep Initiation and Maintenance Disorders-experience-Headache Disorders, Secondary', 'Sleep Initiation and Maintenance Disorders-experience-Pain', 'Carcinoma, Merkel Cell-mimic-Meningeal Neoplasms', 'Neoplasms-mimic-Meningeal Neoplasms', 'Infections-precipitate-Respiratory Tract Diseases', 'Obesity-compare-Cardiovascular Diseases', 'Obesity-predispose-Cardiovascular Diseases', 'Neurodegenerative Diseases-characterized-Tremor', 'Neoplasms-enroll-Death', 'Neurodegenerative Diseases-characterized-Hypokinesia', 'Neurodegenerative Diseases-characterized-Muscle Rigidity', 'Weight Loss-stop-Malnutrition', 'Death-enrolled-Cardiovascular Diseases', 'Fractures, Stress-excluded-Osteoporotic Fractures', 'Ventricular Fibrillation-terminate-Pain', 'Fractures, Stress-present-Polyradiculopathy', 'Osteoporotic Fractures-present-Polyradiculopathy', 'Arrhythmias, Cardiac-classified-Tachycardia, Ventricular', 'Neoplasm Metastasis-accepted-Hydatidiform Mole', 'Alzheimer Disease-related-Memory Disorders', 'Alzheimer Disease-reflect-Memory Disorders', 'Cerebral Infarction-include-Dementia', 'Colorectal Neoplasms-document-Colonic Polyps', 'Stroke-comprise-Cerebral Infarction', 'Death-compare-Alzheimer Disease', 'Death-increase-Alzheimer Disease', 'Gastrointestinal Hemorrhage-relate-Colorectal Neoplasms', 'Chronic Disease-associated-Calcinosis', 'Calcinosis-associated-Chronic Disease', 'Pulmonary Disease, Chronic Obstructive-distinguish-Asthma', 'Brain Infarction-reduce-Pain', 'Neoplasms-estimated-Colorectal Neoplasms', 'Neoplasms-cause-Death', 'Neoplasms-estimated-Death', 'Malnutrition-characterized-Hypoalbuminemia', 'Hemorrhage-guide-Atrial Fibrillation', 'Wounds and Injuries-admitted-Death', 'Death-increase-Wounds and Injuries', 'Atrial Fibrillation-combined-Hemorrhage', 'Atrial Fibrillation-identify-Hemorrhage', 'Tachycardia-treat-Arrhythmias, Cardiac', 'Tachycardia-affect-Fractures, Bone', 'Hypotension-measured-Neoplasms', 'Subarachnoid Hemorrhage-include-Stroke', 'Cerebral Hemorrhage-include-Stroke', 'Stroke-compare-Cerebral Infarction', 'Subarachnoid Hemorrhage-compare-Cerebral Infarction', 'Cerebral Hemorrhage-compare-Cerebral Infarction', 'Alzheimer Disease-trigger-Pulmonary Disease, Chronic Obstructive', 'Atherosclerosis-become-Hypertension', 'Atherosclerosis-become-Kidney Diseases', 'Ulcer-produce-Pain', 'Muscle Hypertonia-report-Fecal Incontinence', 'Spondylolysis-occur-Back Pain', 'Muscle Hypertonia-report-Urinary Incontinence', 'Spondylolysis-occur-Low Back Pain', 'Thyroid Diseases-met-Hyperthyroidism', 'Thyroid Diseases-met-Hypothyroidism', 'Delirium-prevent-Dementia', 'Glycogen Storage Disease-lead-Hepatomegaly', 'Gerstmann-Straussler-Scheinker Disease-lead-Hepatomegaly', 'Diabetes Mellitus-lead-Dementia', 'Fractures, Bone-followed-Hip Fractures', 'Cardiovascular Diseases-estimated-Death', 'Wounds and Injuries-categorized-Myoclonus', 'Dementia-follow-Alzheimer Disease', 'Coronary Artery Disease-defined-Angina Pectoris', 'Epidermolysis Bullosa Acquisita-include-Skin Diseases', 'Pain-associated-Movement Disorders', 'Movement Disorders-associated-Pain', 'Arthritis-associated-Movement Disorders', 'Movement Disorders-associated-Arthritis', 'Heart Failure-associated-Anemia', 'Anemia-associated-Heart Failure', 'Death-increased-Memory Disorders', 'Heart Diseases-progress-Alzheimer Disease', 'Heart Diseases-control-Dementia', 'Stroke-progress-Alzheimer Disease', 'Stroke-control-Dementia', 'Alzheimer Disease-control-Dementia', 'Death-cause-Asthma', 'Dwarfism, Pituitary-identify-Glucose Metabolism Disorders', 'Dwarfism, Pituitary-improve-Glucose Metabolism Disorders', 'Dementia-share-Alzheimer Disease', 'Alzheimer Disease-study-Amnesia', 'Aortitis-emerging-Aortic Aneurysm', 'Thyroid Diseases-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-Thyroid Diseases', 'Hypogonadism-accumulate-Headache Disorders, Secondary', 'Mesial Movement of Teeth-operated-Epilepsy, Temporal Lobe', 'Infections-caused-Pelvic Floor Disorders', 'Alzheimer Disease-reclassified-Aneurysm', 'Heart Failure-tend-Death, Sudden', 'Heart Failure-induce-Death, Sudden', 'Hypertension-diagnosed-Atrial Fibrillation', 'Sleep Apnea, Obstructive-defined-Cerebral Infarction', 'Spinal Cord Injuries-treated-Spinal Injuries', 'Cataract-undergo-Ocular Hypertension', 'Death-develop-Heart Failure', 'Cerebrovascular Disorders-identified-Leukoaraiosis', 'Death-develop-Myocardial Infarction', 'Parkinson Disease-received-Urinary Incontinence', 'Epilepsy-modified-Stroke', 'Epilepsy-modified-Dementia', 'Bone Diseases-increase-Hypertension', 'Epilepsy-modified-Craniocerebral Trauma', 'Dementia-favour-Alzheimer Disease', 'Hip Fractures-suggested-Pain', 'Hip Fractures-suggested-Cardiac Output, Low', 'Migraine Disorders-forced-Headache', 'Photophobia-forced-Headache', 'Sleep Initiation and Maintenance Disorders-discouraged-Amnesia', 'Sleep Initiation and Maintenance Disorders-include-Amnesia', 'Sleep Initiation and Maintenance Disorders-discouraged-Ataxia', 'Sleep Initiation and Maintenance Disorders-include-Ataxia', 'Cardiac Output, Low-predict-Hip Fractures', 'Pain-predict-Hip Fractures', 'Glaucoma-characterized-Ocular Hypertension', 'Wounds and Injuries-influence-Death', 'HIV Infections-seen-Communicable Diseases', 'Neoplasms-include-Colorectal Neoplasms', 'Death-focus-Neoplasms', 'Polyuria-screened-Muscle Hypertonia', 'Nocturia-recognized-Polyuria', 'Polyuria-recognized-Nocturia', 'Dementia-differ-Alzheimer Disease', 'Hyperplasia-induced-Hypoxia', 'Blindness-experience-Heart Arrest', 'Brain Diseases-associated-Alzheimer Disease', 'Alzheimer Disease-associated-Brain Diseases', 'Alzheimer Disease-found-Dementia', 'Death-performed-Neoplasms', 'Hallucinations-occur-Vision Disorders', 'Aortic Valve Stenosis-remain-Heart Valve Diseases', 'Memory Disorders-fall-Alzheimer Disease', 'Mitral Valve Stenosis-compare-Death', 'Mitral Valve Stenosis-show-Death', 'Movement Disorders-occur-Stroke', 'Aortic Aneurysm, Abdominal-represent-Atherosclerosis', 'Lymphoma, B-Cell-correlated-Hepatitis C', 'Death-represent-Atherosclerosis', 'Inflammatory Bowel Diseases-diagnosed-Crohn Disease', 'Inflammatory Bowel Diseases-diagnosed-Colitis, Ulcerative', 'Multiple Myeloma-assess-Neoplasms', 'Multiple Myeloma-use-Neoplasms', 'Neoplasms-quantify-Multiple Myeloma', 'Obesity, Metabolically Benign-linked-Diabetes Mellitus, Type 2', 'Lung Neoplasms-reflect-Neoplasms', 'Lung Neoplasms-influence-Neoplasms', 'Arrhythmias, Cardiac-vary-Ventricular Premature Complexes', 'Diabetes Mellitus-retain-Stroke', 'Dementia-detect-Stroke', 'Metabolic Syndrome-associated-Stroke', 'Stroke-associated-Metabolic Syndrome', 'Urinary Bladder, Overactive-characterized-Urinary Incontinence, Urge', 'Urinary Bladder, Overactive-accompany-Nocturia', 'Poliomyelitis-develop-Infections', 'Long QT Syndrome-range-Death, Sudden', 'Myoclonus-associated-Anemia', 'Anemia-associated-Myoclonus', 'Diabetes Mellitus, Type 2-investigated-Cataract', 'Atherosclerosis-investigated-Cataract', 'Pulmonary Disease, Chronic Obstructive-investigated-Cataract', 'Hypertension-investigated-Cataract', 'Gait Disorders, Neurologic-associated-Cardiac Output, Low', 'Cardiac Output, Low-associated-Gait Disorders, Neurologic', 'Carcinoma, Basal Cell-compare-Neoplasms', 'Jaundice, Obstructive-diagnosed-Neoplasms', 'Hypogonadism-treated-Immunologic Deficiency Syndromes', 'Dyspareunia-treated-Immunologic Deficiency Syndromes', 'Dementia-influence-Delirium', 'Aneurysm-associated-Muscle Rigidity', 'Muscle Rigidity-associated-Aneurysm', 'Urinary Incontinence, Stress-include-Syncope', 'Urinary Bladder, Overactive-include-Syncope', 'Alzheimer Disease-related-Dementia', 'Chromosome Aberrations-associated-Primary Ovarian Insufficiency', 'Primary Ovarian Insufficiency-associated-Chromosome Aberrations', 'Liver Cirrhosis, Biliary-occur-Cholestasis', 'Periodontitis-include-Infections', 'Infections-linked-Atherosclerosis', 'Periodontitis-include-Inflammation', 'Atherosclerosis-treated-Cardiovascular Diseases', 'Inflammation-linked-Atherosclerosis', 'Liver Cirrhosis, Biliary-treated-Cardiovascular Diseases', 'Periodontitis-linked-Atherosclerosis', 'Coronary Artery Disease-related-Diabetes Mellitus', 'Acute Kidney Injury-identified-Severe Acute Respiratory Syndrome', 'Femoral Fractures-modulate-Osteoporosis', 'Heart Failure-decreased-Sensation Disorders', 'Heart Failure-decreased-Fatigue', 'Heart Failure-decreased-Dyspnea', 'Heart Failure-decreased-Nausea', 'Osteoarthritis-report-Pain', 'Neoplasms-become-Ovarian Neoplasms', 'Neoplasms-become-Breast Neoplasms', 'Aneurysm-comprise-Coronary Artery Disease', 'Aneurysm-comprise-Cerebrovascular Disorders', 'Genetic Diseases, Inborn-increase-Fractures, Bone', 'Fractures, Bone-predict-Death', 'Pulmonary Embolism-associated-Ventricular Dysfunction', 'Ventricular Dysfunction-associated-Pulmonary Embolism', 'Aneurysm-seem-Kidney Diseases', 'Cerebrovascular Disorders-seem-Kidney Diseases', 'Colorectal Neoplasms-known-Adenoma', 'Radius Fractures-used-Osteoporotic Fractures', 'Prostatic Hyperplasia-associated-Sexual Dysfunction, Physiological', 'Sexual Dysfunction, Physiological-associated-Prostatic Hyperplasia', 'Renal Insufficiency-related-Death', 'Stroke-include-Aneurysm', 'Alzheimer Disease-increased-Diabetes Mellitus', 'Atrophy-involved-Alzheimer Disease', 'Atrophy-increase-Alzheimer Disease', 'Musculoskeletal Diseases-reduce-Fractures, Bone', 'Neoplasms-treated-Pain', 'Musculoskeletal Diseases-reduce-Kyphosis', 'Fractures, Bone-reduce-Kyphosis', 'Drug-Related Side Effects and Adverse Reactions-clarify-Coronary Artery Disease', 'Pulmonary Disease, Chronic Obstructive-admitted-Pneumonia', 'Respiratory Tract Diseases-become-Death', 'Gait Disorders, Neurologic-base-Death', 'Atrial Fibrillation-include-Arrhythmias, Cardiac', 'Gait Disorders, Neurologic-associated-Death', 'Death-associated-Gait Disorders, Neurologic', 'Neoplasms-minimize-Drug-Related Side Effects and Adverse Reactions', 'Coronary Artery Disease-reflect-Malocclusion', 'Respiratory Tract Diseases-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-Respiratory Tract Diseases', 'Neoplasms-include-Carcinoma, Small Cell', 'Carcinoma, Squamous Cell-include-Neoplasms', 'Adenocarcinoma-include-Neoplasms', 'Stomach Neoplasms-improve-Neoplasms', 'Carcinoma, Squamous Cell-include-Carcinoma, Small Cell', 'Adenocarcinoma-include-Carcinoma, Small Cell', 'Diabetes Mellitus-associated-Cardiac Output, Low', 'Cardiac Output, Low-associated-Diabetes Mellitus', 'Carcinoma, Hepatocellular-show-Inflammation', 'Pain-occur-Osteoarthritis', 'Brain Diseases-characterized-Headache', 'Brain Diseases-characterized-Perceptual Disorders', 'Brain Diseases-characterized-Hypertension', 'Brain Diseases-identify-Pre-Eclampsia', 'Headache-identify-Pre-Eclampsia', 'Seizures-identify-Pre-Eclampsia', 'Brain Diseases-follow-Sepsis', 'Perceptual Disorders-identify-Pre-Eclampsia', 'Hypertension-identify-Pre-Eclampsia', 'Neoplasms-identify-Pulmonary Embolism', 'Breast Neoplasms-compare-Venous Thrombosis', 'Breast Neoplasms-diagnosed-Pulmonary Embolism', 'Cardiovascular Diseases-show-Hypertriglyceridemia', 'Respiratory Tract Infections-caused-Infections', 'Heart Septal Defects, Atrial-result-Heart Diseases', 'Heart Septal Defects, Atrial-result-Hypertension', 'Lens Diseases-associated-Cataract', 'Cataract-associated-Lens Diseases', 'Hip Fractures-increase-Fractures, Bone', 'Wounds and Injuries-invest-Hip Fractures', 'Diabetes Mellitus-include-Vascular Calcification', 'Death-include-Communicable Diseases', 'Hyperphosphatemia-include-Vascular Calcification', 'Wounds and Injuries-invest-Fractures, Bone', 'Hyperparathyroidism-include-Vascular Calcification', 'Death-include-Tuberculosis', 'Death-include-Pneumonia', 'Death-include-Diarrhea', 'Death-include-Hepatitis B', 'Communicable Diseases-include-Death', 'Rubella-report-Communicable Diseases', 'Communicable Diseases-report-Rubella', 'Wounds and Injuries-become-Death', 'Heart Failure-tend-Obesity', 'Dehydration-defined-Muscle Hypotonia', 'Carcinogenesis-include-Stomach Diseases', 'Dementia-admitted-Psychomotor Agitation', 'Dementia-increase-Psychomotor Agitation', 'Vision, Low-notice-Wounds and Injuries', 'Neurodegenerative Diseases-seem-Alzheimer Disease', 'Fractures, Bone-contribute-Muscular Dystrophy, Duchenne', 'Hypertrophy-caused-Fibrosis', 'Renal Insufficiency, Chronic-measured-Kidney Diseases', 'Death-associated-Leukemia, Myeloid, Acute', 'Leukemia, Myeloid, Acute-associated-Death', 'Low Back Pain-associated-Death', 'Death-associated-Low Back Pain', 'Heart Arrest-prevent-Hypothermia', 'Heart Arrest-prevent-Delirium', 'Hypothermia-prevent-Delirium', 'Infections-shorten-Neutropenia', 'Infections-receive-Neoplasms', 'Neutropenia-receive-Neoplasms', 'Diabetes Mellitus-compare-Muscle Hypertonia', 'Neoplasms-include-Stomach Neoplasms', 'Heart Failure-prevent-Cerebral Infarction', 'Renal Insufficiency, Chronic-prevent-Cerebral Infarction', 'Atrial Fibrillation-prevent-Cerebral Infarction', 'Blind Loop Syndrome-associated-Malnutrition', 'Malnutrition-associated-Blind Loop Syndrome', 'Blind Loop Syndrome-associated-Diarrhea', 'Diarrhea-associated-Blind Loop Syndrome', 'Blind Loop Syndrome-associated-Weight Loss', 'Weight Loss-associated-Blind Loop Syndrome', 'Carcinoma, Non-Small-Cell Lung-experience-Drug-Related Side Effects and Adverse Reactions', 'Stroke-recruited-Dementia', 'Dementia-develop-Seizures', 'Seizures-occur-Stroke', 'Cardiovascular Diseases-involve-Nervous System Diseases', 'Death-reported-Meningeal Neoplasms', 'Gallstones-associated-Pancreatitis', 'Pancreatitis-associated-Gallstones', 'Osteoporosis-treat-Fractures, Bone', 'Hip Fractures-occur-Death', 'Memory Disorders-seen-Dementia', 'Cerebral Amyloid Angiopathy-increased-Parkinson Disease', 'Pain-result-Hyperkeratosis, Epidermolytic', 'Intracranial Hemorrhage, Hypertensive-increased-Parkinson Disease', 'Pulmonary Embolism-defined-Dyspnea', 'Pulmonary Embolism-defined-Chest Pain', 'Cardiovascular Diseases-identified-Death', 'Hyperkinesis-decrease-Dyspareunia', 'Hip Fractures-predict-Fractures, Bone', 'Infertility, Female-present-Ovarian Diseases', 'Hip Fractures-separated-Fractures, Bone', 'Infertility, Female-present-Oculocerebrorenal Syndrome', 'Memory Disorders-develop-Alzheimer Disease', 'Dementia-develop-Alzheimer Disease', 'Endometrial Neoplasms-receive-Neoplasms', 'Wounds and Injuries-caused-Femoral Fractures', 'Fractures, Bone-sustain-Oculocerebrorenal Syndrome', 'Wounds and Injuries-caused-Death', 'Retinal Diseases-develop-Diabetes Mellitus', 'Hypotension-occur-Dwarfism, Pituitary', 'Atherosclerosis-occur-Dwarfism, Pituitary', 'Dystonia-distinguished-Gait Disorders, Neurologic', 'Neoplasms-use-Death', 'Fibrosis-related-Hepatitis C', 'Hyperlipidemias-associated-Periodontitis', 'Periodontitis-associated-Hyperlipidemias', 'Glioblastoma-excluded-Neoplasms', 'Stroke-treated-Infarction, Middle Cerebral Artery', 'Bacterial Infections-classified-Inflammation', 'Retinal Diseases-associated-Acute Kidney Injury', 'Acute Kidney Injury-associated-Retinal Diseases', 'Ovarian Diseases-become-Neurologic Manifestations', 'Parkinson Disease-characterized-Hypokinesia', 'Parkinson Disease-characterized-Tremor', 'Diabetes Mellitus-affect-Cerebral Infarction', 'Parkinson Disease-characterized-Muscle Rigidity', 'Diabetes Mellitus-affect-Stroke', 'Osteoarthritis-confirmed-Pain', 'Calcinosis-associated-Carotid Artery Diseases', 'Carotid Artery Diseases-associated-Calcinosis', 'Calcinosis-associated-Brain Ischemia', 'Brain Ischemia-associated-Calcinosis', 'Calcinosis-found-Diabetes Mellitus', 'Sepsis-associated-Infections', 'Infections-associated-Sepsis', 'Calcinosis-found-Hyperlipidemias', 'Atrioventricular Block-associated-Heart Failure', 'Heart Failure-associated-Atrioventricular Block', 'Diabetes Mellitus-increase-Fractures, Bone', 'Infarction, Middle Cerebral Artery-characterized-Death', 'Lung Neoplasms-undergo-Neoplasms', 'Diabetes Mellitus-associated-Fractures, Bone', 'Fractures, Bone-associated-Diabetes Mellitus', 'Pneumococcal Infections-increase-Drug-Related Side Effects and Adverse Reactions', 'Glucose Intolerance-associated-Fractures, Bone', 'Fractures, Bone-associated-Glucose Intolerance', 'Glucose Intolerance-differ-Diabetes Mellitus', 'Diabetes Mellitus-differ-Fractures, Bone', 'Malocclusion-fall-Cardiac Output, Low', 'Immunologic Deficiency Syndromes-result-Fractures, Bone', 'Cardiac Output, Low-fall-Vestibular Diseases', 'Death-associated-Aneurysm, Infected', 'Aneurysm, Infected-associated-Death', 'Alcoholism-result-Dementia', 'Cerebrovascular Trauma-performed-Stroke', 'Obesity-remain-Chronic Disease', 'Stroke-performed-Aneurysm', 'Kidney Diseases-reduce-Diabetes Mellitus', 'Anophthalmos-measure-Retinal Artery Occlusion', 'Lung Diseases-characterised-Airway Obstruction', 'Signs and Symptoms, Respiratory-recognise-Asthma', 'Osteoporotic Fractures-appear-Osteoporosis', 'Vestibular Diseases-experience-Vertigo', 'Headache-accepted-Hydrocephalus', 'Hydrocephalus-remain-Dementia', 'Hydrocephalus-remain-Gait Apraxia', 'Hydrocephalus-remain-Urinary Incontinence', 'Pneumothorax-differentiate-Parkinson Disease', 'Atrophy-include-Stroke', 'Leukoaraiosis-leave-Dementia', 'Headache Disorders, Secondary-prevent-Osteoporosis', 'Obesity-prevent-Diabetes Mellitus', 'Dyslipidemias-prevent-Diabetes Mellitus', 'Diabetes Mellitus-impair-Hypoglycemia', 'Dementia-misdiagnosed-Alzheimer Disease', 'Hallux Valgus-lead-Pain', 'Diabetes Mellitus-lower-Coronary Artery Disease', 'Metabolic Syndrome-lower-Coronary Artery Disease', 'Fractures, Bone-undergo-Heel Spur', 'Hyperparathyroidism, Secondary-increase-Fractures, Bone', 'Alzheimer Disease-examine-Death', 'Hyperhomocysteinemia-contribute-Osteoporosis', 'Psychomotor Disorders-identify-Dementia', 'Chemical and Drug Induced Liver Injury-cause-Hepatitis B, Chronic', 'Infections-enhance-Inflammation', 'Hepatitis B, Chronic-monitored-Hepatitis B', 'Hypertension-include-Coronary Artery Disease', 'Diabetes Mellitus-include-Coronary Artery Disease', 'Hypercholesterolemia-include-Coronary Artery Disease', 'Death-obtained-Wounds and Injuries', 'Diabetes Mellitus-regarded-Death', 'Mucocutaneous Lymph Node Syndrome-indicate-Inflammation', 'Retinal Artery Occlusion-differentiate-Ischemia', 'Retinal Artery Occlusion-help-Ocular Hypertension', 'Retinal Artery Occlusion-represent-Ocular Hypertension', 'Hypertension-affect-Stroke', 'Stroke-followed-Carotid Stenosis', 'Stroke-followed-Hypercholesterolemia', 'Retinal Vein Occlusion-differentiate-Ischemia', 'Stroke-followed-Ischemia', 'Retinal Vein Occlusion-help-Ocular Hypertension', 'Stroke-followed-Diabetes Mellitus', 'Diabetes Mellitus-appear-Death', 'Stroke-followed-Heart Diseases', 'Ischemia-differentiate-Retinal Artery Occlusion', 'Ischemia-help-Ocular Hypertension', 'Ischemia-differentiate-Ocular Hypertension', 'Ischemia-differentiate-Venous Thrombosis', 'Diabetes Mellitus-cause-Death', 'Glaucoma, Neovascular-help-Ocular Hypertension', 'Severe Acute Respiratory Syndrome-associated-Death', 'Death-associated-Severe Acute Respiratory Syndrome', 'Severe Acute Respiratory Syndrome-cause-Death', 'Severe Acute Respiratory Syndrome-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-Severe Acute Respiratory Syndrome', 'Ocular Hypertension-help-Venous Thrombosis', 'Chronic Disease-sustain-Malnutrition', 'Arthritis-followed-Stroke', 'Diabetes Mellitus-suggest-Metabolic Diseases', 'Metabolic Diseases-suggest-Diabetes Mellitus, Type 2', 'Hypertension-treated-Diabetes Mellitus', 'Carcinoma, Squamous Cell-obtained-Neoplasms', 'Carcinoma, Basal Cell-obtained-Neoplasms', 'Death-recorded-Cardiovascular Diseases', 'Hip Fractures-affected-Anemia', 'Hypertension-include-Atherosclerosis', 'Obesity-include-Atherosclerosis', 'Cytomegalovirus Infections-include-Atherosclerosis', 'Heart Diseases-present-Heart Failure', 'Atrophy-observed-Multiple Sclerosis', 'Postthrombotic Syndrome-related-Thrombosis', 'Osteoporosis-caused-Death', 'Stroke-associated-Dyslipidemias', 'Dyslipidemias-associated-Stroke', 'Memory Disorders-sent-Urinary Bladder Neoplasms', 'Stroke-present-Atrophy', 'Death-remain-Neoplasms', 'Coronary Artery Disease-predict-Dementia', 'Stroke-predict-Dementia', 'Aneurysm-predict-Dementia', 'Pain-used-Chronic Pain', 'Parkinsonian Disorders-associated-Death', 'Death-associated-Parkinsonian Disorders', 'Osteoporosis-associated-Chronic Disease', 'Chronic Disease-associated-Osteoporosis', 'Alzheimer Disease-suffer-Dementia', 'Arteriovenous Malformations-caused-Constriction, Pathologic', 'Death-suspected-Aneurysm', 'Coronary Artery Disease-suspected-Aneurysm', 'Cerebral Infarction-include-Stroke', 'Postpartum Hemorrhage-considered-Endometrial Neoplasms', 'Death-considered-Endometrial Neoplasms', 'Neoplasms-patterned-Lung Neoplasms', 'Atrial Fibrillation-predispose-Stroke', 'Infections-involved-Asthma', 'Heart Failure-caused-Hypotension', 'Osteoporotic Fractures-lead-Pain', 'Osteoporotic Fractures-lead-Musculoskeletal Diseases', 'Heart Failure-evidence-Death', 'Skin Neoplasms-comprise-Neoplasms', 'Seizures-associated-Epilepsies, Partial', 'Epilepsies, Partial-associated-Seizures', 'Seizures-associated-Thinness', 'Thinness-associated-Seizures', 'Seizures-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-Seizures', 'Seizures-constitute-Metabolic Syndrome', 'Skin Neoplasms-occur-Carcinoma, Squamous Cell', 'Epilepsies, Partial-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-Epilepsies, Partial', 'Epilepsies, Partial-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-Epilepsies, Partial', 'Skin Neoplasms-include-Carcinoma, Merkel Cell', 'Skin Neoplasms-occur-Carcinoma, Merkel Cell', 'Skin Neoplasms-consist-Neoplasm Metastasis', 'Epilepsies, Partial-associated-Metabolic Syndrome', 'Metabolic Syndrome-associated-Epilepsies, Partial', 'Epilepsies, Partial-constitute-Metabolic Syndrome', 'Death-include-Carcinoma, Squamous Cell', 'Death-occur-Carcinoma, Squamous Cell', 'Thinness-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-Thinness', 'Thinness-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-Thinness', 'Death-include-Carcinoma, Merkel Cell', 'Death-occur-Carcinoma, Merkel Cell', 'Thinness-associated-Metabolic Syndrome', 'Metabolic Syndrome-associated-Thinness', 'Thinness-constitute-Metabolic Syndrome', 'Cardiovascular Diseases-include-Metabolic Syndrome', 'Cardiovascular Diseases-constitute-Metabolic Syndrome', 'Diabetes Mellitus-include-Metabolic Syndrome', 'Diabetes Mellitus-constitute-Metabolic Syndrome', 'Ossification of Posterior Longitudinal Ligament-use-Chest Pain', 'Appendicitis-carry-Death', 'Neurodegenerative Diseases-based-Death', 'HIV Infections-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-HIV Infections', 'Heart Failure-magnified-Renal Insufficiency, Chronic', 'Heart Failure-magnified-Anemia', 'Colitis-considered-Gastrointestinal Diseases', 'Myotonic Dystrophy-characterize-Intellectual Disability', 'Parkinson Disease-known-Cardiac Output, Low', 'Colitis, Collagenous-considered-Gastrointestinal Diseases', 'Colitis, Lymphocytic-considered-Gastrointestinal Diseases', 'Cold Injury-associated-Death', 'Death-associated-Cold Injury', 'Memory Disorders-precede-Dementia', 'Heart Failure-increasing-Death', 'Atrial Fibrillation-compare-Dementia', 'Communicable Diseases-chondrocytes-Joint Diseases', 'Neoplasms-used-Neoplasm Invasiveness', 'Neoplasms-identify-Neoplasm Invasiveness', 'Prostatic Neoplasms-compare-Neoplasms', 'Prostatic Neoplasms-compare-Death', 'Neck Pain-bear-Multiple Myeloma', 'Nervous System Diseases-bear-Multiple Myeloma', 'Eyelid Diseases-described-Obesity', 'Eyelid Diseases-described-Headache Disorders, Secondary', 'Arthritis-undergo-Pain', 'Stomach Neoplasms-affect-Infections', 'Diabetes Mellitus-compared-Hypertension', 'Diabetes Mellitus-increase-Dementia, Vascular', 'Calcinosis-represent-Atherosclerosis', 'Pain-assessed-Osteoarthritis, Hip', 'Pain-assessed-Rheumatic Diseases', 'Muscle Rigidity-include-Parkinsonian Disorders', 'Gait Disorders, Neurologic-include-Parkinsonian Disorders', 'Hypokinesia-include-Parkinsonian Disorders', 'Muscle Rigidity-associated-Death', 'Death-associated-Muscle Rigidity', 'Hypokinesia-associated-Death', 'Death-associated-Hypokinesia', 'Retinal Vein Occlusion-associated-Vascular System Injuries', 'Vascular System Injuries-associated-Retinal Vein Occlusion', 'Hyperhomocysteinemia-associated-Coronary Artery Disease', 'Coronary Artery Disease-associated-Hyperhomocysteinemia', 'Coronary Artery Disease-examine-Chronic Disease', 'Diabetes Mellitus-examine-Chronic Disease', 'Coronary Artery Disease-examine-Hypertension', 'Diabetes Mellitus-examine-Hypertension', 'Coronary Artery Disease-examine-Hypercholesterolemia', 'Diabetes Mellitus-examine-Hypercholesterolemia', 'Coronary Artery Disease-examine-Gastritis', 'Diabetes Mellitus-examine-Gastritis', 'Death-cause-Coronary Artery Disease', 'Kidney Diseases-considered-Hypertension', 'Pneumonia-associated-Arbovirus Infections', 'Arbovirus Infections-associated-Pneumonia', 'Nocturia-associated-Dry Eye Syndromes', 'Dry Eye Syndromes-associated-Nocturia', 'Nocturia-associated-Xerostomia', 'Xerostomia-associated-Nocturia', 'Inflammation-demonstrated-Cardiovascular Diseases', 'Ventricular Dysfunction, Left-associated-Heart Diseases', 'Heart Diseases-associated-Ventricular Dysfunction, Left', 'Ventricular Dysfunction, Left-associated-Hypertrophy', 'Hypertrophy-associated-Ventricular Dysfunction, Left', 'Kidney Failure, Chronic-calculated-Kidney Diseases', 'Hypertension-examine-Cardiovascular Diseases', 'Appendicitis-perforated-Acute Coronary Syndrome', 'Appendicitis-masquerade-Acute Coronary Syndrome', 'Nausea-occur-Diarrhea', 'Musculoskeletal Diseases-reported-Neoplasms', 'Optic Neuropathy, Ischemic-refer-Ischemia', 'Optic Neuropathy, Ischemic-refer-Vision Disorders', 'Atrial Fibrillation-associated-Ventricular Dysfunction, Left', 'Ventricular Dysfunction, Left-associated-Atrial Fibrillation', 'Wounds and Injuries-lead-Tricuspid Valve Insufficiency', 'Vision Disorders-implicated-Cardiac Output, Low', 'Bone Diseases, Metabolic-found-Prostatic Neoplasms', 'Vision Disorders-fall-Fractures, Bone', 'Osteoporosis-found-Prostatic Neoplasms', 'Cerebrovascular Disorders-develop-Dementia', 'Seizures-remain-Epilepsy', 'Seizures-include-Epilepsy', 'Muscle Hypertonia-associated-Death', 'Death-associated-Muscle Hypertonia', 'Alkaptonuria-characterized-Cartilage Diseases', 'Inflammation-associated-Neurocysticercosis', 'Neurocysticercosis-associated-Inflammation', 'Parasitic Diseases-associated-Neurocysticercosis', 'Neurocysticercosis-associated-Parasitic Diseases', 'Cardiovascular Diseases-play-Death', 'Hyperglycemia-alter-Glucose Metabolism Disorders', 'Diabetes Mellitus-alter-Glucose Metabolism Disorders', 'Renal Insufficiency-alter-Glucose Metabolism Disorders', 'Aortic Valve Stenosis-resemble-Atherosclerosis', 'Diabetes Mellitus-regard-Stroke', 'Diabetes Mellitus-known-Stroke', 'Diabetes Mellitus-regard-Death', 'Diabetes Mellitus-known-Death', 'Peripheral Nervous System Diseases-include-Paraplegia', 'Deglutition Disorders-evaluate-Stroke', 'Brain Injuries, Traumatic-qualify-Wounds and Injuries', 'Weight Loss-increase-Obesity', 'Calcinosis-associate-Coronary Artery Disease', 'Coronary Artery Disease-associate-Calcinosis', 'Low Back Pain-associated-Back Pain', 'Back Pain-associated-Low Back Pain', 'Stroke-include-Embolism', 'Cerebral Infarction-include-Embolism', 'Heart Diseases-include-Embolism', 'Rheumatic Diseases-include-Embolism', 'Heart Valve Diseases-include-Embolism', 'Hypertension-include-Embolism', 'Heart Failure-include-Embolism', 'Ventricular Dysfunction, Left-include-Embolism', 'Arterial Occlusive Diseases-occur-Arteriosclerosis', 'Diabetes Mellitus-include-Embolism', 'Coronary Artery Disease-include-Embolism', 'Kyphosis-associated-Dyspnea', 'Dyspnea-associated-Kyphosis', 'Neoplasms-performed-Death', 'Breast Neoplasms-result-Death', 'Hypertrophy-justified-Cardiomyopathy, Hypertrophic', 'Neoplasms-followed-Multiple Organ Failure', 'Pneumonia-followed-Heart Failure', 'Pneumonia-followed-Myocardial Infarction', 'Pain-regain-Osteoporotic Fractures', 'Breast Neoplasms-develop-Neoplasm Metastasis', 'Dementia, Vascular-identified-Dementia', 'Dementia, Vascular-include-Infarction', 'Dementia, Vascular-identified-Infarction', 'Ulcer-seen-Wounds and Injuries', 'Ulcer-seen-Spinal Cord Injuries', 'Ulcer-seen-Neurologic Manifestations', 'Ulcer-seen-Peripheral Vascular Diseases', 'Ulcer-seen-Stroke', 'Glomerulonephritis-treated-Polymyalgia Rheumatica', 'Myasthenia Gravis-improve-Headache Disorders, Secondary', 'Kidney Diseases-associated-Nephrotic Syndrome', 'Nephrotic Syndrome-associated-Kidney Diseases', 'Death-implicate-Dementia', 'Dementia-implicate-Death', 'Diabetes Mellitus-known-Retinal Diseases', 'Periodontal Diseases-measured-Periodontal Attachment Loss', 'Periodontal Diseases-measured-Hemorrhage', 'Periodontal Diseases-measured-Inflammation', 'Macular Degeneration-precipitate-Retinal Diseases', 'Inflammation-precipitate-Retinal Diseases', 'Retinal Diseases-precipitate-Retinal Neoplasms', 'Alzheimer Disease-associated-Stroke', 'Stroke-associated-Alzheimer Disease', 'Periodontal Diseases-increase-Death', 'Bone Diseases, Metabolic-take-Immunologic Deficiency Syndromes', 'Osteoporosis-take-Immunologic Deficiency Syndromes', 'Hypotension, Orthostatic-investigate-Myocardial Infarction', 'Rupture-identified-Heart Arrest', 'Alzheimer Disease-suggest-Dementia', 'Rupture-identified-Death, Sudden', 'Heart Arrest-caused-Rupture', 'Heart Arrest-remain-Death', 'Rupture-remain-Death', 'Urinary Incontinence-perceived-Neoplasms', 'Chickenpox-carry-Death', 'Alzheimer Disease-characterized-Glucose Metabolism Disorders', 'Brain Diseases-characterized-Glucose Metabolism Disorders', 'Thrombosis-avoid-Hemorrhage', 'Death-control-Alzheimer Disease', 'Diabetes Mellitus-contribute-Coronary Artery Disease', 'Hypertension-contribute-Coronary Artery Disease', 'Vision Disorders-attributed-Cataract', 'Heart Arrest-evaluated-Atrial Fibrillation', 'Colorectal Neoplasms-undergo-Adenomatous Polyps', 'Immunologic Deficiency Syndromes-linked-Parkinson Disease', 'Immunologic Deficiency Syndromes-linked-Alzheimer Disease', 'Death-related-Meningitis, Bacterial', 'Nocturia-attributed-Prostatitis', 'Meningitis-associated-Death', 'Death-associated-Meningitis', 'Osteoarthritis, Hip-gain-Pain', 'Dyskeratosis Congenita-characterized-Bone Marrow Failure Disorders', 'Dyskeratosis Congenita-caused-Genetic Diseases, Inborn', 'Skin Diseases-consist-Blister', 'Skin Diseases-consist-Skin Neoplasms', 'Osteoporosis-combine-Fractures, Bone', 'Osteoporosis-make-Fractures, Bone', 'Low Back Pain-associated-Pain', 'Pain-associated-Low Back Pain', 'Weight Loss-measured-Obesity', 'Kidney Diseases-associated-Anemia', 'Anemia-associated-Kidney Diseases', 'Stroke-confer-Dementia', 'Dementia-examine-Stroke', 'Atherosclerosis-associated-Kidney Diseases', 'Kidney Diseases-associated-Atherosclerosis', 'Dementia, Vascular-include-Nervous System Diseases', 'Dementia, Vascular-include-Stroke', 'Dementia-recognized-Alzheimer Disease', 'Embolism, Cholesterol-avoid-Atherosclerosis', 'Blindness-defined-Vision Disorders', 'Leukoencephalopathies-associated-Gait Disorders, Neurologic', 'Gait Disorders, Neurologic-associated-Leukoencephalopathies', 'Leukoencephalopathies-associated-Urinary Incontinence', 'Urinary Incontinence-associated-Leukoencephalopathies', 'Colorectal Neoplasms-associated-Neoplasms', 'Neoplasms-associated-Colorectal Neoplasms', 'Dyskinesias-induce-Brain Diseases', 'Dyskinesias-related-Brain Diseases', 'Neuralgia-develop-Herpes Zoster', 'Chronic Pain-develop-Herpes Zoster', 'Thrombosis-place-Venous Thrombosis', 'Alzheimer Disease-treated-Pain', 'Arthritis-treated-Pain', 'Rheumatic Diseases-treated-Pain', 'Coronary Artery Disease-divided-Myocardial Infarction', 'Death-compared-Arm Injuries', 'Femoral Neck Fractures-undergo-Fractures, Bone', 'Death, Sudden-attributed-Heart Failure', 'Death-attributed-Heart Failure', 'Death, Sudden-attributed-Stroke', 'Death-attributed-Stroke', 'Pain-use-Osteoarthritis', 'Prostatic Hyperplasia-caused-Sexual Dysfunction, Physiological', 'Neutropenia-represent-Neoplasms', 'Coronary Artery Disease-studied-Death', 'Death-use-Osteoporotic Fractures', 'Death-estimate-Osteoporotic Fractures', 'Dementia-associated-Leukoaraiosis', 'Leukoaraiosis-associated-Dementia', 'Stroke-associated-Leukoaraiosis', 'Leukoaraiosis-associated-Stroke', 'Hypertension-affect-Cerebral Hemorrhage', 'Obesity-affect-Cerebral Hemorrhage', 'Systemic Vasculitis-cause-Vision Disorders', 'Femoral Neck Fractures-attributed-Bone Neoplasms', 'Hip Fractures-attributed-Bone Neoplasms', 'Ischemia-contribute-Cardiomyopathies', 'Wounds and Injuries-sustain-Upper Extremity Deformities, Congenital', 'Inflammation-play-Cardiovascular Diseases', 'Stroke-obtained-Death', 'Pelvic Inflammatory Disease-associated-Mastocytosis, Systemic', 'Mastocytosis, Systemic-associated-Pelvic Inflammatory Disease', 'Cerebral Infarction-found-Hypertension', 'Optic Atrophy-appear-Vascular System Injuries', 'Tetany-monitor-Neuromuscular Manifestations', 'Diabetes Mellitus-tested-Albuminuria', 'Obesity-tested-Albuminuria', 'Shock-result-Death', 'Sleep Wake Disorders-screen-Alzheimer Disease', 'Epilepsy-associated-Stroke', 'Stroke-associated-Epilepsy', 'Epilepsy-associated-Dementia', 'Dementia-associated-Epilepsy', 'Drug-Related Side Effects and Adverse Reactions-make-Neoplasms', 'Headache-correspond-Hypertension', 'Adenoma-followed-Hyperthyroidism', 'Colorectal Neoplasms-based-Neoplasms', 'Mitral Valve Insufficiency-identify-Diabetes Mellitus', 'Mitral Valve Insufficiency-matched-Diabetes Mellitus', 'Dementia-surveyed-Stroke', 'Stroke-met-Dementia', 'Mitral Valve Insufficiency-undergo-Aortic Valve Stenosis', 'Neoplasms-perform-Lung Neoplasms', 'Neoplasms-perform-Carcinoma, Non-Small-Cell Lung', 'Drug-Related Side Effects and Adverse Reactions-receive-Carcinoma, Non-Small-Cell Lung', 'Pneumonia-receive-Carcinoma, Non-Small-Cell Lung', 'Heart Failure-differentiate-Dyspnea', 'Drug-Related Side Effects and Adverse Reactions-assess-Lymphoma', 'Parkinson Disease, Secondary-reflect-Parkinsonian Disorders', 'Pain-associated-Dysmenorrhea', 'Dysmenorrhea-associated-Pain', 'Fractures, Bone-associated-Oculocerebrorenal Syndrome', 'Oculocerebrorenal Syndrome-associated-Fractures, Bone', 'Carcinoma, Non-Small-Cell Lung-avoided-Weight Loss', 'Breast Neoplasms-cause-Bone Marrow Diseases', 'Delirium-associated-Respiratory Tract Infections', 'Respiratory Tract Infections-associated-Delirium', 'Delirium-treated-Respiratory Tract Infections', 'Coronary Artery Disease-screen-Atherosclerosis', 'Adenoma-cure-Hyperparathyroidism', 'Hyperparathyroidism, Primary-denied-Parathyroid Neoplasms', 'Hypothyroidism-mistaken-Muscle Weakness', 'Hypothyroidism-mistaken-Lethargy', 'Hypothyroidism-mistaken-Fatigue', 'Dementia-discriminate-Alzheimer Disease', 'Pain, Postoperative-result-Ocular Hypertension', 'Pain, Postoperative-occur-Cataract', 'Dementia-discriminate-Parkinson Disease', 'Ocular Hypertension-occur-Cataract', 'Thyroid Neoplasms-show-Neoplasm Metastasis', 'Diabetes Mellitus-follow-Death', 'Joint Diseases-examined-Arthritis, Rheumatoid', 'Death-achieve-Tuberculosis', 'Lower Extremity Deformities, Congenital-include-Infections', 'Lower Extremity Deformities, Congenital-protect-Infections', 'Wounds and Injuries-include-Lower Extremity Deformities, Congenital', 'Lower Extremity Deformities, Congenital-develop-Neoplasms', 'Airway Obstruction-associated-Sleep Wake Disorders', 'Sleep Wake Disorders-associated-Airway Obstruction', 'Airway Obstruction-verify-Pulmonary Disease, Chronic Obstructive', 'Adenoma-account-Polyps', 'Communicable Diseases-increase-Death', 'Death-revise-Dementia', 'Stroke-develop-Dementia', 'Stroke-contribute-Dementia', 'Adenocarcinoma-affected-Cholecystitis', 'Osteoarthritis-influence-Pain', 'Myocardial Infarction-repeated-Heart Failure', 'Stroke-complete-Cerebral Infarction', 'Hyperhomocysteinemia-associated-Gastritis, Atrophic', 'Gastritis, Atrophic-associated-Hyperhomocysteinemia', 'Myocardial Infarction-seen-Heart Failure', 'Heart Failure-hospitalized-Myocardial Infarction', 'Myocardial Infarction-hospitalized-Hyperlipidemias', 'Stroke-observe-Cerebral Infarction', 'Prostatic Hyperplasia-analyzed-Gangliosidosis, GM1', 'Alzheimer Disease-reflect-Dementia', 'Alzheimer Disease-begin-Dementia', 'Metabolic Diseases-compare-Coronary Artery Disease', 'Leukoencephalopathies-provide-Alzheimer Disease', 'Coronary Artery Disease-promote-Metabolic Diseases', 'Metabolic Diseases-predispose-Atherosclerosis', 'Alzheimer Disease-cause-Confusion', 'Alzheimer Disease-associated-Vision Disorders', 'Vision Disorders-associated-Alzheimer Disease', 'Confusion-associated-Atrophy', 'Atrophy-associated-Confusion', 'Confusion-associated-Vision Disorders', 'Vision Disorders-associated-Confusion', 'Memory Disorders-accompany-Alzheimer Disease', 'Kidney Failure, Chronic-caused-Hypertension', 'Hypertrophy, Left Ventricular-caused-Hypertension', 'Hypertension-show-Hypotension', 'Spinal Diseases-associated-Osteoporosis', 'Osteoporosis-associated-Spinal Diseases', 'Colorectal Neoplasms-investigate-Neoplasms', 'Renal Insufficiency-affected-Renal Artery Obstruction', 'Hypertension-affected-Renal Artery Obstruction', 'Renal Artery Obstruction-affected-Renal Insufficiency', 'Giant Cell Arteritis-consist-Pain', 'Ischemia-increase-Heart Failure', 'Hyponatremia-occur-Hypopituitarism', 'Ischemia-increase-Death', 'Hypertension, Pulmonary-associated-Hypertension', 'Hypertension-associated-Hypertension, Pulmonary', 'Weight Loss-manage-Obesity', 'Cardiovascular Diseases-assess-Diabetes Mellitus, Type 2', 'Nerve Degeneration-lead-Spinal Stenosis', 'Neoplasms-registered-Niemann-Pick Disease, Type C', 'Heart Failure-ascribed-Hypotension', 'Cardiac Output, Low-include-Urinary Incontinence', 'Peptic Ulcer-associated-Xerostomia', 'Xerostomia-associated-Peptic Ulcer', 'Progeria-admitted-Craniocerebral Trauma', 'Periodontal Diseases-caused-Infections', 'Aneurysm-suffer-Subarachnoid Hemorrhage', 'Sarcopenia-prevent-Chronic Disease', 'Cataract-exhibit-Diabetes Mellitus', 'Diabetes Mellitus-associated-Myocardial Infarction', 'Myocardial Infarction-associated-Diabetes Mellitus', 'Death-underlie-Pneumonia', 'Bone Marrow Diseases-develop-Carcinoma, Squamous Cell', 'Dementia-evaluate-Diabetes Mellitus', 'Dementia, Vascular-develop-Diabetes Mellitus', 'Breast Neoplasms-put-Death', 'Diabetes Mellitus-related-Dementia', 'Weight Loss-lead-Cachexia', 'Melanoma-result-Drug-Related Side Effects and Adverse Reactions', 'Heart Failure-reduce-Stroke', 'Periodontal Diseases-prevent-Tooth Loss', 'Myocardial Infarction-reduce-Stroke', 'Carcinoma, Hepatocellular-show-Infections', 'Pain, Postoperative-differ-Postoperative Complications', 'Hypotension-associated-Atrial Fibrillation', 'Atrial Fibrillation-associated-Hypotension', 'Hypotension-associated-Arrhythmias, Cardiac', 'Arrhythmias, Cardiac-associated-Hypotension', 'Pulmonary Disease, Chronic Obstructive-decrease-Death', 'Fractures, Bone-identified-Wounds and Injuries', 'Fibrosis-decrease-Death', 'Heart Failure-demonstrate-Death', 'Myocardial Infarction-cross-validate-Heart Diseases', 'Musculoskeletal Pain-followed-Muscle Weakness', 'Refractive Errors-studied-Eye Diseases', 'Hip Fractures-undergo-Venous Thrombosis', 'Alzheimer Disease-associated-Brain Damage, Chronic', 'Brain Damage, Chronic-associated-Alzheimer Disease', 'Metabolic Syndrome-become-Obesity', 'Pelvic Neoplasms-associated-Rectal Diseases', 'Rectal Diseases-associated-Pelvic Neoplasms', 'Death-associated-Fractures, Open', 'Fractures, Open-associated-Death', 'Fractures, Open-associated-Rectal Diseases', 'Rectal Diseases-associated-Fractures, Open', 'Aneurysm-defined-Renal Artery Obstruction', 'Stroke-preexist-Dementia', 'Graft vs Host Disease-include-Drug-Related Side Effects and Adverse Reactions', 'Death-include-Drug-Related Side Effects and Adverse Reactions', 'Inflammation-support-Alzheimer Disease', 'Inflammation-support-Atherosclerosis', 'Malformations of Cortical Development-detected-Dementia', 'Polycystic Kidney Diseases-found-Ovarian Cysts', 'Calcinosis-result-Constriction, Pathologic', 'Ovarian Neoplasms-found-Ovarian Cysts', 'Femoral Neck Fractures-undertreated-Osteoporosis', 'Hypotension-recognized-Syncope', 'Weight Loss-controlled-Hypertension', 'Spinal Cord Injuries-involve-Myoclonus', 'Unconsciousness-associated-Edema', 'Edema-associated-Unconsciousness', 'Unconsciousness-associated-Contusions', 'Contusions-associated-Unconsciousness', 'Hemangiosarcoma-arise-Lymphedema', 'Stomach Ulcer-include-Peptic Ulcer', 'Ulcer-include-Peptic Ulcer', 'Atherosclerosis-associated-Cerebral Infarction', 'Cerebral Infarction-associated-Atherosclerosis', 'Stomach Ulcer-include-Ulcer', 'Glucose Intolerance-precede-Diabetes Mellitus', 'Sclerosis-linked-Seizures', 'Chorea-associated-Hyperglycemia', 'Hyperglycemia-associated-Chorea', 'Diabetes Mellitus-present-Fever', 'Diabetes Mellitus-present-Urinary Tract Infections', 'Diabetes Mellitus-harbour-Prostatitis', 'Fever-harbour-Prostatitis', 'Urinary Tract Infections-harbour-Prostatitis', 'Acute Coronary Syndrome-develop-Delirium', 'Infections-develop-Delirium', 'Brain Injuries-develop-Delirium', 'Neoplastic Syndromes, Hereditary-develop-Delirium', 'Hyperkinesis-result-Fatigue', 'Delirium-associated-Drug-Related Side Effects and Adverse Reactions', 'Drug-Related Side Effects and Adverse Reactions-associated-Delirium', 'Delirium-reported-Drug-Related Side Effects and Adverse Reactions', 'Neoplasms-found-Prostatic Neoplasms', 'Pain-experienced-Arthritis', 'Dementia-contribute-Alzheimer Disease', 'Tuberculosis-obtained-Asthma', 'Tibial Fractures-treated-Wounds and Injuries', 'Infections-related-Cardiovascular Diseases', 'Sleep Wake Disorders-based-Substance-Related Disorders', 'Alzheimer Disease-show-Infections', 'Atrophy-evaluated-Alzheimer Disease', 'Hepatomegaly-evaluated-Alzheimer Disease', 'Cerebral Hemorrhage-diagnosed-Stroke', 'Stroke-diagnosed-Cerebral Hemorrhage', 'Cerebral Hemorrhage-show-Death', 'Death-show-Cerebral Hemorrhage', 'Cerebral Amyloid Angiopathy-related-Atherosclerosis', 'Hydrocephalus-relieve-Neurocysticercosis', 'Headache Disorders, Secondary-measured-Delirium', 'Diabetes Mellitus-compare-Malnutrition', 'Hepatitis C, Chronic-reduce-Death', 'Myocardial Infarction-identify-Cerebral Infarction', 'Atrophy-associated-Dementia', 'Dementia-associated-Atrophy', 'Alzheimer Disease-confirmed-Dementia', 'Alzheimer Disease-confirmed-Dementia, Vascular', 'Dementia, Vascular-follow-Dementia', 'Stroke-impair-Aneurysm', 'Sleep Wake Disorders-diagnosed-Dementia', 'Cardiac Output, Low-admitted-Hip Fractures', 'Gastritis, Atrophic-associated-Infections', 'Infections-associated-Gastritis, Atrophic', 'Shock-implicated-Cartilage Diseases', 'Shock-implicated-Arthritis, Rheumatoid', 'Shock-implicated-Osteoarthritis', 'Parkinson Disease-include-Alzheimer Disease', 'Diabetes Mellitus-include-Hemochromatosis', 'Joint Diseases-include-Hemochromatosis', 'Diabetes Mellitus-include-Myocardial Infarction', 'Arrhythmias, Cardiac-include-Hemochromatosis', 'Erectile Dysfunction-include-Hemochromatosis', 'Adenocarcinoma-include-Colorectal Neoplasms', 'Lymphoma-include-Colorectal Neoplasms', 'Streptococcal Infections-continue-Infections', 'Streptococcal Infections-found-Diabetes Mellitus', 'Lewy Body Disease-develop-Parkinson Disease', 'Stroke-assess-Cardiomyopathy, Hypertrophic', 'Dementia-develop-Parkinson Disease', 'Adrenal Insufficiency-appreciated-Cardiomyopathy, Hypertrophic', 'Stroke-show-Cardiomyopathy, Hypertrophic', 'Diabetes Mellitus-prevent-Hypertension', 'Meniere Disease-appear-Tinnitus', 'Neoplasms-account-Colorectal Neoplasms', 'Musculoskeletal Pain-defined-Pain', 'Rheumatic Diseases-involve-Arthritis, Rheumatoid', 'Vascular Calcification-assess-Cardiovascular Diseases', 'Venous Thrombosis-occur-Neoplasms', 'Carotid Artery Diseases-assess-Constriction, Pathologic', 'Dry Eye Syndromes-undergo-Arterial Occlusive Diseases', 'Huntington Disease-associated-Anemia', 'Anemia-associated-Huntington Disease', 'Ischemia-associated-Coronary Artery Disease', 'Coronary Artery Disease-associated-Ischemia', 'Angina, Unstable-protect-Death', 'Angina, Unstable-protect-Myocardial Infarction', 'Airway Obstruction-determine-Asthma', 'Hematologic Diseases-undergo-Death', 'Macular Degeneration-suffer-Breast Neoplasms', 'Polymyalgia Rheumatica-associated-Mitochondrial Diseases', 'Mitochondrial Diseases-associated-Polymyalgia Rheumatica', 'Stroke-evaluate-Dementia', 'Breast Neoplasms-treated-Neoplasms', 'Restless Legs Syndrome-lead-Sleep Initiation and Maintenance Disorders', 'Nervous System Diseases-lead-Sleep Initiation and Maintenance Disorders', 'Neurologic Manifestations-associated-Leukoencephalopathies', 'Leukoencephalopathies-associated-Neurologic Manifestations', 'Atrial Fibrillation-reduce-Stroke', 'Heterotaxy Syndrome-associated-Death', 'Death-associated-Heterotaxy Syndrome', 'Heterotaxy Syndrome-inhibit-Hypertrophy, Left Ventricular', 'Death-inhibit-Hypertrophy, Left Ventricular', 'Hip Fractures-receive-Osteoporosis', 'Sleep Initiation and Maintenance Disorders-defined-Cardiac Output, Low', 'Carcinoma, Squamous Cell-remain-Dysphonia', 'Diabetic Neuropathies-increase-Foot Ulcer', 'Central Serous Chorioretinopathy-present-Back Pain', 'Giant Cell Arteritis-cause-Blindness', 'Vasculitis-cause-Blindness', 'Asthma-defined-Airway Obstruction', 'Pulmonary Disease, Chronic Obstructive-defined-Airway Obstruction', 'Fractures, Bone-fall-Cardiac Output, Low', 'Dementia-found-Diabetes Mellitus', 'Spinal Cord Injuries-survive-Cardiovascular Diseases', 'Status Epilepticus-associate-Death', 'Death-associate-Status Epilepticus', 'Atherosclerosis-include-Cerebral Infarction', 'Drug-Related Side Effects and Adverse Reactions-used-Pancreatic Neoplasms', 'Dementia-account-Cerebrovascular Disorders', 'Sleep Initiation and Maintenance Disorders-related-Obesity', 'Sleep Initiation and Maintenance Disorders-related-Alcoholism', 'Inflammatory Bowel Diseases-conducted-Erectile Dysfunction', 'Dyspnea-identify-Respiratory Tract Diseases', 'Constriction, Pathologic-progress-Airway Obstruction', 'Asthma-recruited-Drug Hypersensitivity', 'Colorectal Neoplasms-performed-Death', 'Death-undergo-Cataract', 'Death-occur-Coronary Artery Disease', 'Delirium-attributed-Lupus Erythematosus, Systemic', 'Fractures, Bone-occur-Oculocerebrorenal Syndrome', 'Stroke-compare-Atrial Fibrillation', 'Stroke-suffer-Atrial Fibrillation', 'Headache-suffer-Migraine Disorders', 'Headache-obtain-Cerebral Infarction', 'Headache-hospitalized-Cerebral Infarction', 'Migraine Disorders-develop-Cerebral Infarction', 'Obesity-appear-Diabetes Mellitus', 'Heart Arrest-performed-Death', 'Heart Arrest-performed-Stroke', 'Xeroderma Pigmentosum-associate-Skin Neoplasms', 'Skin Neoplasms-associate-Xeroderma Pigmentosum', 'Psoriasis-monitor-Bone Marrow Diseases', 'Tuberculosis-used-Death', 'Hypothalamic Neoplasms-promote-Neurodegenerative Diseases', 'Pruritus Ani-predominate-Neoplasms', 'Hypothalamic Neoplasms-reported-Alzheimer Disease', 'Neurodegenerative Diseases-reported-Alzheimer Disease', 'Heart Diseases-predominate-Neoplasms', 'Hepatitis, Viral, Human-superimposed-Liver Diseases', 'Hepatitis B-superimposed-Liver Diseases', 'Hepatitis C, Chronic-superimposed-Liver Diseases', 'Atrophy-show-Alzheimer Disease', 'Death-decline-Coronary Artery Disease', 'Infections-indicated-Arthritis', 'Obesity-contribute-Sleep Wake Disorders', 'Sleep Wake Disorders-increase-Respiratory Insufficiency', 'Eyelid Diseases-related-Blepharoptosis', 'Aneurysm-elevated-Kidney Diseases', 'Shock, Septic-enrolled-Sepsis', 'Peptic Ulcer-include-Gastritis, Atrophic', 'Dyspepsia-determined-Atrophy', 'Hypertension-contribute-Death', 'Death-contribute-Hypertension', 'Cockayne Syndrome-cause-Cachexia', 'Cockayne Syndrome-cause-Nervous System Diseases', 'Shy-Drager Syndrome-cause-Cachexia', 'Shy-Drager Syndrome-cause-Nervous System Diseases', 'Immunologic Deficiency Syndromes-manifested-Chemical and Drug Induced Liver Injury', 'Hemangioma-include-Neoplasms', 'Hemangiosarcoma-include-Neoplasms', 'Communicable Diseases-include-Neoplasms', 'Inflammation-related-Death', 'Inflammation-found-Death', 'Granuloma, Pyogenic-include-Neoplasms', 'Osteoarthritis-represent-Pain', 'Hyperthyroidism-increase-Dementia', 'Cerebral Infarction-found-Scleroderma, Systemic', 'Heart Block-associated-Myocardial Infarction', 'Myocardial Infarction-associated-Heart Block', 'Esophageal Neoplasms-associated-Gastroesophageal Reflux', 'Gastroesophageal Reflux-associated-Esophageal Neoplasms', 'Microsatellite Instability-occur-Colonic Neoplasms', 'Weight Gain-implicated-Coronary Artery Disease', 'Weight Gain-implicated-Diabetes Mellitus, Type 2', 'Ovarian Neoplasms-undergo-Ovarian Diseases', 'Hyperlipidemias-treat-Coronary Artery Disease', 'Chlamydia Infections-recognised-Pelvic Infection', 'Chlamydia Infections-recognised-Infertility, Female', 'Seizures-fit-Inflammation', 'Alzheimer Disease-result-Heart Failure', 'Sleep Wake Disorders-assess-Death', 'Psychoses, Substance-Induced-followed-Death', 'Bone Diseases, Metabolic-observed-Arthritis, Rheumatoid', 'Abnormalities, Drug-Induced-caused-Rubella', 'Sleep Wake Disorders-associated-Cardiac Output, Low', 'Cardiac Output, Low-associated-Sleep Wake Disorders', 'Delirium-associated-Muscle Weakness', 'Muscle Weakness-associated-Delirium', 'Osteoporosis-exceed-Death', 'Aneurysm-increase-Rupture', 'Osteoporosis-exceed-Hip Fractures', 'Kidney Failure, Chronic-treated-Sepsis', 'Death-caused-Sepsis', 'Shock-seen-Ventricular Septal Rupture', 'Atrophy-differ-Alzheimer Disease', 'Hemianopsia-caused-Cerebral Infarction', 'Glucose Intolerance-increase-Hypotension', 'Myocardial Infarction-precipitate-Heart Failure', 'Atrophy-match-Alzheimer Disease', 'Neoplasms-combine-Melanoma', 'Melanoma-combine-Lymphoma, Non-Hodgkin', 'Weight Loss-change-Obesity', 'Proteinuria-cause-Death', 'Proteinuria-cause-Cardiovascular Diseases', 'Metabolic Diseases-appear-Urolithiasis', 'Heart Failure-related-Coronary Artery Disease', 'Death-related-Coronary Artery Disease', 'Pneumococcal Infections-carry-Death', 'Disease Susceptibility-recognized-Parkinson Disease', 'Disease Susceptibility-recognized-Alzheimer Disease', 'Hypertension-decrease-Stroke', 'Psychomotor Agitation-tolerate-Basal Ganglia Diseases', 'Stroke-include-Hemorrhage', 'Rhinitis, Allergic-include-Nose Diseases', 'Thrombocytosis-referred-Optic Neuropathy, Ischemic', 'Thrombocytosis-referred-Diplopia', 'Thrombocytosis-referred-Amaurosis Fugax', 'Thrombocytosis-referred-Headache', 'Dementia-demonstrate-Stroke', 'Coronary Artery Disease-account-Death', 'Movement Disorders-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-Movement Disorders', 'Movement Disorders-recal-Cardiovascular Diseases', 'Chest Pain-sustain-Death', 'Aortic Aneurysm, Abdominal-associated-Atherosclerosis', 'Atherosclerosis-associated-Aortic Aneurysm, Abdominal', 'Hip Fractures-associated-Coronary Artery Disease', 'Coronary Artery Disease-associated-Hip Fractures', 'Hip Fractures-associated-Neoplasms', 'Neoplasms-associated-Hip Fractures', 'Osteoarthritis-determined-Pain', 'Osteoarthritis-determined-Obesity', 'Atrophy-define-Hypertension', 'Hyperlipidemias-related-Atherosclerosis', 'Ischemia-present-Pain', 'Colitis, Ischemic-present-Pain', 'Heart Failure-related-Inflammation', 'Edema-live-Inflammation', 'Edema-live-Drug-Related Side Effects and Adverse Reactions', 'Edema-live-Brain Injuries, Traumatic', 'Angina Pectoris-associated-Ischemia', 'Ischemia-associated-Angina Pectoris', 'Edema-live-Alzheimer Disease', 'Myocardial Infarction-associated-Ischemia', 'Ischemia-associated-Myocardial Infarction', 'Edema-live-Stroke', 'Edema-live-Genetic Diseases, Inborn', 'Inflammation-live-Drug-Related Side Effects and Adverse Reactions', 'Gastroesophageal Reflux-reduce-Mucositis', 'Inflammation-live-Brain Injuries, Traumatic', 'Inflammation-live-Alzheimer Disease', 'Inflammation-live-Stroke', 'Inflammation-live-Genetic Diseases, Inborn', 'Drug-Related Side Effects and Adverse Reactions-associated-Brain Injuries, Traumatic', 'Brain Injuries, Traumatic-associated-Drug-Related Side Effects and Adverse Reactions', 'Prodromal Symptoms-associated-Death', 'Death-associated-Prodromal Symptoms', 'Drug-Related Side Effects and Adverse Reactions-associated-Alzheimer Disease', 'Alzheimer Disease-associated-Drug-Related Side Effects and Adverse Reactions', 'Drug-Related Side Effects and Adverse Reactions-associated-Stroke', 'Stroke-associated-Drug-Related Side Effects and Adverse Reactions', 'Drug-Related Side Effects and Adverse Reactions-associated-Genetic Diseases, Inborn', 'Genetic Diseases, Inborn-associated-Drug-Related Side Effects and Adverse Reactions', 'Gout-associated-Hyperuricemia', 'Hyperuricemia-associated-Gout', 'Respiratory Tract Infections-associated-Death', 'Death-associated-Respiratory Tract Infections', 'Osteoarthritis-characterized-Neurodegenerative Diseases', 'Wounds and Injuries-demonstrate-Death', 'Death-influenced-Gangrene', 'Intestinal Atresia-influenced-Gangrene', 'Subarachnoid Hemorrhage-mediate-Vasospasm, Intracranial', 'Subarachnoid Hemorrhage-cause-Ischemia', 'Coronary Artery Disease-obtained-Hypertension', 'Cerebrovascular Disorders-obtained-Hypertension', 'HIV Infections-predict-Acquired Immunodeficiency Syndrome', 'Diabetes Mellitus-obtained-Hypertension', 'Coronary Artery Disease-manifest-Erectile Dysfunction', 'Neoplasms-obtained-Hypertension', 'Death-decrease-Atrial Fibrillation', 'Peptic Ulcer-cause-Death', 'Infections-associated-Scabies', 'Scabies-associated-Infections', 'Infections-associated-Trench Fever', 'Trench Fever-associated-Infections', 'HIV Infections-associated-Scabies', 'Scabies-associated-HIV Infections', 'Hydrocephalus-follow-Subarachnoid Hemorrhage', 'Periodontal Attachment Loss-indicate-Death', 'Infections-associated-Mastocytosis, Systemic', 'Mastocytosis, Systemic-associated-Infections', 'Atrial Fibrillation-influence-Death', 'Cerebral Infarction-develop-Pneumonia', 'Neoplasms-rank-Lung Neoplasms', 'Neoplasms-rank-Prostatic Neoplasms', 'Sleep Wake Disorders-assessed-Cardiovascular Diseases', 'Lung Neoplasms-rank-Prostatic Neoplasms', 'Myocardial Infarction-include-Death', 'Lung Neoplasms-rank-Breast Neoplasms', 'Porphyria Cutanea Tarda-taken-Fibrosis', 'Lung Injury-associated-Pneumonia', 'Pneumonia-associated-Lung Injury', 'Lung Injury-associated-Death', 'Death-associated-Lung Injury', 'Adrenal Gland Neoplasms-associated-Virilism', 'Virilism-associated-Adrenal Gland Neoplasms', 'Headache Disorders, Secondary-suffer-Hereditary Angioedema Type III', 'Plaque, Atherosclerotic-associated-Cerebral Infarction', 'Cerebral Infarction-associated-Plaque, Atherosclerotic', 'Cardiovascular Diseases-influenced-Diabetes Mellitus', 'Death-influenced-Diabetes Mellitus', 'Death-use-Brain Injuries, Traumatic', 'Leukoaraiosis-predict-Death', 'Hip Fractures-associated-Hypotension', 'Hypotension-associated-Hip Fractures', 'Leukoaraiosis-predict-Pneumonia', 'Leukoaraiosis-predict-Neurologic Manifestations', 'Infections-include-Streptococcal Infections', 'Dementia-appear-Alzheimer Disease', 'Protein S Deficiency-seem-Retinal Vein Occlusion', 'Bloom Syndrome-cause-Growth Disorders', 'Bloom Syndrome-cause-Immunologic Deficiency Syndromes', 'Genetic Diseases, Inborn-cause-Growth Disorders', 'Genetic Diseases, Inborn-cause-Immunologic Deficiency Syndromes', 'Death-assessed-Mitral Valve Stenosis', 'Delirium-appear-Dementia', 'Delirium-appear-Death', 'Hypertension-increased-Cardiovascular Diseases', 'Neoplasms-represent-Death', 'Cholecystitis, Acute-constitute-Death', 'Plaque, Atherosclerotic-shown-Cerebral Infarction', 'Bacteremia-defined-Infections', 'Dementia-followed-Death', 'Dementia-obtained-Death', 'Aneurysm-implicated-Gastrointestinal Hemorrhage', 'Atherosclerosis-prevent-Hematoma', 'Breast Neoplasms-associated-Obesity, Abdominal', 'Obesity, Abdominal-associated-Breast Neoplasms', 'Nervous System Diseases-mediated-Brain Diseases', 'Parkinson Disease-complicated-Dyskinesia, Drug-Induced', 'Diabetes Mellitus-considered-Infections', 'Aortic Diseases-studied-Heart Arrest', 'Heart Diseases-mentioned-Hypertension', 'Ovarian Diseases-play-Neoplasms', 'Arthritis-used-Osteoarthritis', 'Arthritis-measure-Osteoarthritis', 'Osteoarthritis-recruited-Arthritis', 'Leukoencephalopathies-indicate-Leukoaraiosis', 'Reflex, Abnormal-indicate-Leukoaraiosis', 'Leukoaraiosis-associated-Urinary Bladder, Neurogenic', 'Urinary Bladder, Neurogenic-associated-Leukoaraiosis', 'Leukemia-employed-Leukemia, Myeloid, Acute', 'Leukemia-evolve-Leukemia, Myeloid, Acute', 'Leukemia-employed-Myelodysplastic Syndromes', 'Leukemia-evolve-Myelodysplastic Syndromes', 'Asthma-accompanied-Chest Pain', 'Leukemia, Myeloid, Acute-evolve-Myelodysplastic Syndromes', 'Asthma-accompanied-Dyspnea', 'Glaucoma-target-Glaucoma, Open-Angle', 'Rheumatic Diseases-associated-Neoplasms', 'Neoplasms-associated-Rheumatic Diseases', 'Neoplasms-include-Rheumatic Diseases', 'Rheumatic Diseases-justify-Neoplasms', 'Central Nervous System Neoplasms-declining-Death', 'Neoplasms-declining-Death', 'Cardiovascular Diseases-associated-Glucose Metabolism Disorders', 'Glucose Metabolism Disorders-associated-Cardiovascular Diseases', 'Seizures-cause-Death', 'Death-calculated-Dementia', 'Death-calculated-Alzheimer Disease', 'Death-calculated-Dementia, Vascular', 'Peptic Ulcer-treated-Cardiomyopathy, Dilated', 'Neoplasms-induce-Thyroid Carcinoma, Anaplastic', 'Blindness-caused-Cataract', 'Dementia, Vascular-attributed-Infarction', 'Dementia, Vascular-related-Infarction', 'Pituitary Diseases-associated-Hypopituitarism', 'Hypopituitarism-associated-Pituitary Diseases', 'Nervous System Diseases-selected-Dementia', 'Death-associated-Hypopituitarism', 'Hypopituitarism-associated-Death', 'Hypopituitarism-associated-Aneurysm', 'Aneurysm-associated-Hypopituitarism', 'Dementia, Vascular-compared-Stroke', 'Stroke-associated-Dementia, Vascular', 'Dementia, Vascular-associated-Stroke', 'Polyps-exclude-Gallstones', 'Stroke-reduce-Atrial Fibrillation', 'Death-compare-Atrial Fibrillation', 'Death-reduce-Atrial Fibrillation', 'Aortic Valve Stenosis-increase-Heart Valve Diseases', 'Aortic Diseases-associated-Myocardial Infarction', 'Myocardial Infarction-associated-Aortic Diseases', 'Aortic Diseases-associated-Ventricular Outflow Obstruction', 'Ventricular Outflow Obstruction-associated-Aortic Diseases', 'Death-joine-Ventricular Septal Rupture', 'Heart Diseases-replace-Aortic Aneurysm', 'Heart Diseases-treat-Infections', 'Tuberculosis-diagnosed-Death', 'Bacteremia-associated-Death', 'Death-associated-Bacteremia', 'Lung Neoplasms-associated-Neoplastic Syndromes, Hereditary', 'Neoplastic Syndromes, Hereditary-associated-Lung Neoplasms', 'Hypoadrenocorticism, Familial-produce-Endocrine Gland Neoplasms', 'Adrenal Gland Diseases-produce-Endocrine Gland Neoplasms', 'Joint Diseases-demonstrated-Arthritis, Psoriatic', 'Diabetes Mellitus-related-Cystic Fibrosis', 'Diabetes Mellitus-become-Cystic Fibrosis', 'Hypertension-involve-Weight Loss', 'Weight Loss-provide-Hypertension', 'Death-predicted-Heart Failure', 'Diabetes Mellitus-predicted-Heart Failure', 'Aortic Aneurysm, Abdominal-determine-Death', 'Neoplasms-done-Pancreatic Neoplasms', 'Hypertrophy, Left Ventricular-associated-Heart Diseases', 'Heart Diseases-associated-Hypertrophy, Left Ventricular', 'Hypertrophy, Left Ventricular-associated-Arrhythmias, Cardiac', 'Arrhythmias, Cardiac-associated-Hypertrophy, Left Ventricular', 'Hypertrophy, Left Ventricular-compared-Hypertension', 'Eye Diseases-include-Breast Neoplasms, Male', 'Headache-include-Breast Neoplasms, Male', 'Erectile Dysfunction-include-Breast Neoplasms, Male', 'Infections-caused-Nervous System Diseases', 'Gastritis-involve-Esophageal Neoplasms', 'Neoplasms-compared-Thyroid Neoplasms', 'Werner Syndrome-compared-Thyroid Neoplasms', 'Thyroid Neoplasms-compared-Neoplasms', 'Werner Syndrome-compared-Neoplasms', 'Hyperparathyroidism-caused-Kidney Diseases', 'Hyperparathyroidism-confer-Fractures, Bone', 'Alzheimer Disease-result-Cardiac Output, Low', 'Lung Diseases-follow-Breast Neoplasms', 'Headache Disorders, Secondary-tend-Drug Hypersensitivity', 'Headache Disorders, Secondary-become-Drug Hypersensitivity', 'Headache Disorders, Secondary-decrease-Drug Hypersensitivity', 'Heart Failure-ascertain-Death', 'Inflammatory Bowel Diseases-occur-Death', 'Vision Disorders-exite-Hypertension', 'Myocardial Infarction-increase-Death', 'Prostatitis-associated-Prostatic Hyperplasia', 'Prostatic Hyperplasia-associated-Prostatitis', 'Stroke-request-Cerebrovascular Disorders', 'Chronic Disease-contribute-Femoral Neuropathy', 'Ischemia-request-Cerebrovascular Disorders', 'Osteoarthritis-used-Pain', 'Stroke-define-Death', 'Hypoxia-implicated-Kidney Diseases', 'Hypoxia-implicated-Acute Kidney Injury', 'Hematoma-stem-Wounds and Injuries', 'Hematoma-occur-Neoplasms', 'Tachycardia-compare-Arrhythmias, Cardiac', 'Tachycardia-affected-Arrhythmias, Cardiac', 'Kyphosis-taken-Pain', 'Scoliosis-taken-Pain', 'Kyphosis-measure-Quadriplegia', 'Scoliosis-measure-Quadriplegia', 'Neoplasms-withstand-Hypoxia', 'Stroke-contribute-Alzheimer Disease', 'Heart Failure, Systolic-matched-Hypertrophy', 'Necrosis-misdiagnosed-Vision Disorders', 'Death-suffer-Wounds and Injuries', 'Drug-Related Side Effects and Adverse Reactions-measure-Postpartum Hemorrhage', 'Death-document-Heart Failure', 'Hypertension-overlap-Cardiomyopathy, Hypertrophic', 'Blindness-related-Cataract', 'Wounds and Injuries-suffer-Death', 'Postpartum Hemorrhage-compare-Osteoarthritis', 'Arteritis-present-Vision Disorders', 'Immunologic Deficiency Syndromes-include-Sleep Initiation and Maintenance Disorders', 'Immunologic Deficiency Syndromes-include-Muscle Weakness', 'Immunologic Deficiency Syndromes-include-Erectile Dysfunction', 'Stroke-related-Dementia', 'Arbovirus Infections-play-Meningitis, Bacterial', 'Death-increase-Lung Diseases', 'Death-increased-Peptic Ulcer', 'Cardiac Output, Low-fall-Leukoencephalopathies', 'Heart Arrest-acquire-Death', 'Arthritis-associated-Gallstones', 'Gallstones-associated-Arthritis', 'Death-associated-Lung Neoplasms', 'Lung Neoplasms-associated-Death', 'Glaucoma-undergo-Cataract', 'Microaneurysm-found-Cerebral Amyloid Angiopathy', 'Necrosis-found-Cerebral Amyloid Angiopathy', 'Psychoses, Substance-Induced-based-Severe Acute Respiratory Syndrome', 'Nervous System Diseases-include-Alzheimer Disease', 'Epiglottitis-describe-Deglutition Disorders', 'Epiglottitis-impair-Deglutition Disorders', 'Central Serous Chorioretinopathy-present-Retinal Diseases', 'Ischemia-include-Ischemic Attack, Transient', 'Atherosclerosis-include-Ischemic Attack, Transient', 'Urinary Incontinence, Stress-caused-Cough', 'Cardiomyopathy, Hypertrophic-contrast-Hypertrophy', 'Hypertension-decrease-Renal Insufficiency', 'Adenocarcinoma-influenced-Neoplasms', 'Euthyroid Sick Syndromes-associated-Hypoalbuminemia', 'Hypoalbuminemia-associated-Euthyroid Sick Syndromes', 'Euthyroid Sick Syndromes-associated-Death', 'Death-associated-Euthyroid Sick Syndromes', 'Euthyroid Sick Syndromes-diagnosed-Death', 'Neoplasms-treated-Colonic Neoplasms', 'Cerebral Infarction-increase-Death', 'Craniocerebral Trauma-use-Amnesia', 'Colonic Neoplasms-operated-Neoplasms', 'Hypertension-lower-Cardiovascular Diseases', 'Death-decrease-Ulcer', 'Myelodysplastic Syndromes-precede-Leukemia, Myeloid, Acute', 'Thrombosis-considered-Arteriovenous Malformations', 'Heart Failure-hospitalized-Cardiovascular Diseases', 'Memory Disorders-diagnosed-Alzheimer Disease', 'Weight Loss-constitute-Hypertension', 'Neoplasms-occur-Pituitary Neoplasms', 'Neoplasms-occur-Adenoma', 'Neoplasms-occur-Neurologic Manifestations', 'Neoplasms-occur-Endocrine System Diseases', 'Nervous System Diseases-associated-Wasting Disease, Chronic', 'Wasting Disease, Chronic-associated-Nervous System Diseases', 'Nervous System Diseases-associated-Long QT Syndrome', 'Long QT Syndrome-associated-Nervous System Diseases', 'Sleep Wake Disorders-describe-Cardiovascular Diseases', 'Leukemia, Lymphocytic, Chronic, B-Cell-increase-Skin Neoplasms', 'Neoplasms-increase-Skin Neoplasms', 'Abdominal Pain-reflect-Colonic Neoplasms', 'Headache Disorders, Secondary-reflect-Colonic Neoplasms', 'Neoplasms-occur-Skin Neoplasms', 'Death-decrease-Cardiovascular Diseases', 'Genetic Diseases, Inborn-associated-Venous Thromboembolism', 'Venous Thromboembolism-associated-Genetic Diseases, Inborn', 'Neurologic Manifestations-include-Glomerulonephritis', 'Stroke-assessed-Death', 'Cerebral Infarction-assessed-Death', 'Carcinoma, Hepatocellular-complicated-Liver Abscess', 'Hypertension-screened-Aneurysm', 'Infections-associated-Stomach Ulcer', 'Stomach Ulcer-associated-Infections', 'Infections-associated-Gastrointestinal Hemorrhage', 'Gastrointestinal Hemorrhage-associated-Infections', 'Atherosclerosis-assessed-Myocardial Infarction', 'Atherosclerosis-assessed-Stroke', 'Cardiovascular Diseases-assessed-Myocardial Infarction', 'Gastroesophageal Reflux-present-Deglutition Disorders', 'Cardiovascular Diseases-assessed-Stroke', 'Gastroesophageal Reflux-present-Chest Pain', 'Cerebral Small Vessel Diseases-exacerbated-Hypertension', 'Cerebral Small Vessel Diseases-exacerbated-Diabetes Mellitus', 'Dyspnea-ascribed-Hypotension', 'Death-accumulate-Hip Fractures', 'Carotid Stenosis-diagnose-Hypertension', 'Hypertrophy, Left Ventricular-associated-Hypertension', 'Hypertension-associated-Hypertrophy, Left Ventricular', 'Bronchitis-associated-Death', 'Death-associated-Bronchitis', 'Heredodegenerative Disorders, Nervous System-identify-Respiratory Tract Infections', 'Diabetes Mellitus-include-Polyneuropathies', 'Coronary Artery Disease-include-Aneurysm', 'Death-number-Wounds and Injuries', 'Varicose Ulcer-base-Ulcer', 'Coronary Artery Disease-predict-Death', 'Skin Neoplasms-attributed-Melanoma', 'Death-attributed-Melanoma', 'Cholangitis-undergo-Choledocholithiasis', 'Arthritis-include-Stroke', 'Hypertension-reduce-Cardiovascular Diseases', 'Stroke-show-Hypertension', 'Death-undergo-Colorectal Neoplasms', 'Stupor-associated-Cerebrovascular Disorders', 'Cerebrovascular Disorders-associated-Stupor', 'Psychomotor Agitation-associated-Dementia', 'Dementia-associated-Psychomotor Agitation', 'Psychoses, Substance-Induced-associated-Dementia', 'Dementia-associated-Psychoses, Substance-Induced', 'Atherosclerosis-reported-Coronary Artery Disease', 'Heart Failure-preceded-Hypertension', 'Death-admitted-Myocardial Infarction', 'Hypertension-preceded-Heart Failure', 'Spondylitis-diagnosed-Pain', 'Spondylitis-diagnosed-Inflammation', 'Glucose Intolerance-impaired-Hypertension', 'Diabetes Mellitus-predispose-Atherosclerosis', 'Hypertension-predispose-Atherosclerosis', 'Infections-affected-Chronic Disease', 'Infections-affected-Immunologic Deficiency Syndromes', 'Death-affected-Chronic Disease', 'Death-affected-Immunologic Deficiency Syndromes', 'Dementia, Vascular-differentiate-Alzheimer Disease', 'Coronary Artery Disease-include-Myocardial Infarction', 'Coronary Artery Disease-include-Angina Pectoris', 'Dementia-occur-Learning Disabilities', 'Learning Disabilities-occur-Dementia', 'Death-attributed-Coronary Artery Disease', 'Coronary Artery Disease-attributed-Myocardial Infarction', 'Carcinoma, Merkel Cell-behave-Neoplasm Metastasis', 'Carcinoma, Merkel Cell-behave-Neoplasms', 'Obesity-include-Osteoarthritis', 'Carcinoma, Merkel Cell-treated-Neoplasms', 'Alzheimer Disease-associated-Anemia', 'Anemia-associated-Alzheimer Disease', 'Coronary Artery Disease-associated-Stroke', 'Stroke-associated-Coronary Artery Disease', 'Coronary Artery Disease-associated-Neoplasms', 'Neoplasms-associated-Coronary Artery Disease', 'Hypoglycemia-experience-Cardiac Output, Low', 'Cerebrovascular Disorders-related-Dementia', 'Astrocytoma-followed-Optic Nerve Glioma', 'Hip Fractures-related-Death', 'Oligodendroglioma-followed-Optic Nerve Glioma', 'Oligodendroglioma-followed-Astrocytoma', 'Optic Nerve Glioma-reviewed-Neoplasms', 'Astrocytoma-reviewed-Neoplasms', 'Oligodendroglioma-reviewed-Neoplasms', 'Dementia-recognize-Memory Disorders', 'Diabetes Mellitus, Type 1-diagnosed-Diabetes Mellitus', 'Heart Valve Diseases-predispose-Endocarditis', 'Atrial Fibrillation-diagnosed-Dementia', 'Dementia-related-Atrial Fibrillation', 'Dementia, Vascular-related-Atrial Fibrillation', 'Heart Block-cause-Ocular Hypertension', 'Death-suffer-Lung Neoplasms', 'Stroke-predict-Death', 'Aortic Aneurysm, Abdominal-screen-Hypertension', 'Parkinson Disease, Secondary-aggravate-Parkinson Disease', 'Ischemia-include-Hypertension', 'Stroke-include-Hypertension', 'Leukoencephalopathies-associated-Infarction', 'Infarction-associated-Leukoencephalopathies', 'Leukoencephalopathies-occur-Infarction', 'Tendinopathy-predict-Chondrocalcinosis', 'Primary Ovarian Insufficiency-investigated-Cardiovascular Diseases', 'Cardiomyopathy, Hypertrophic-characterized-Arrhythmias, Cardiac', 'Cardiomyopathy, Hypertrophic-characterized-Death, Sudden', 'Genetic Diseases, Inborn-characterized-Cardiomyopathy, Hypertrophic', 'Genetic Diseases, Inborn-characterized-Arrhythmias, Cardiac', 'Genetic Diseases, Inborn-characterized-Death, Sudden', 'Colitis, Ischemic-considered-Colitis', 'Hip Fractures-associated-Urinary Incontinence', 'Urinary Incontinence-associated-Hip Fractures', 'Macular Degeneration-observed-Atrophy', 'Stroke-increase-Cerebral Infarction', 'Shock, Septic-include-Streptococcal Infections', 'Fasciitis, Necrotizing-include-Streptococcal Infections', 'Plaque, Atherosclerotic-suggested-Cerebral Infarction', 'Ulcer-tend-Stroke', 'Plaque, Atherosclerotic-suggested-Stroke', 'Plaque, Atherosclerotic-tend-Stroke', 'Weight Loss-associated-Hip Fractures', 'Hip Fractures-associated-Weight Loss', 'Pulmonary Embolism-experience-Choroid Hemorrhage', 'Pulmonary Embolism-experience-Retinal Detachment', 'Hyperphosphatemia-describe-Colonic Diseases', 'Musculoskeletal Pain-associated-Respiratory Distress Syndrome', 'Respiratory Distress Syndrome-associated-Musculoskeletal Pain', 'Heat Stroke-investigated-Fever', 'Heat Stroke-admitted-Fever', 'Death-occur-Meningeal Carcinomatosis', 'Hyperparathyroidism-cause-Bone Neoplasms', 'Hyperparathyroidism-cause-Fractures, Bone', 'Gastritis-cause-Infections', 'Infections-cause-Gastritis', 'Respiratory Distress Syndrome-identified-Substance-Related Disorders', 'Infections-cause-Stomach Neoplasms', 'Brain Neoplasms-include-Neoplasms', 'Glioblastoma-include-Neoplasms', 'Deglutition Disorders-cause-Death', 'Vascular Calcification-associated-Atherosclerosis', 'Atherosclerosis-associated-Vascular Calcification', 'Hearing Disorders-precede-Alzheimer Disease', 'Neoplasms-originate-Hernia, Hiatal', 'Hypertension-associated-Hyperkinesis', 'Hyperkinesis-associated-Hypertension', 'Gastrointestinal Diseases-result-Neoplasms', 'Gastrointestinal Diseases-result-Hernia, Hiatal', 'Neoplasms-associated-Hernia, Hiatal', 'Hernia, Hiatal-associated-Neoplasms', 'Death-examine-Amnesia', 'Nocturia-determine-Sleep Wake Disorders', 'Atherosclerosis-exist-Coronary Artery Disease', 'Carcinoma, Non-Small-Cell Lung-account-Death', 'Fasciitis-misdiagnosed-Sarcoma', 'Brain Neoplasms-reported-Neoplasms', 'Dementia-describe-Learning Disabilities', 'Corneal Diseases-measure-Diabetes Mellitus', 'Dehydration-formulate-Death', 'Diabetes Mellitus-recognized-Heart Failure', 'Diabetes Mellitus-recognized-Myocardial Infarction', 'Subarachnoid Hemorrhage-review-Death', 'Death-highlight-Neoplasms', 'Retinal Diseases-include-Neurodegenerative Diseases', 'Glaucoma, Open-Angle-cause-Vision Disorders', 'Syncope-caused-Hypotension', 'Dyskinesia, Drug-Induced-present-Brain Damage, Chronic', 'Dyskinesia, Drug-Induced-present-Brain Injuries, Traumatic', 'Cardiac Output, Low-lead-Fractures, Bone', 'Gastroesophageal Reflux-diagnosed-Heartburn', 'Gastroesophageal Reflux-diagnosed-Esophageal Neoplasms', 'Gastrointestinal Diseases-diagnosed-Heartburn', 'Gastrointestinal Diseases-diagnosed-Esophageal Neoplasms', 'Hypertension-cause-Death', 'Hypertension-cause-Obesity', 'Death-cause-Obesity', 'Heartburn-require-Gastrointestinal Diseases', 'Gastrointestinal Diseases-require-Gastroesophageal Reflux', 'Gastrointestinal Diseases-require-Esophageal Diseases', 'Gastrointestinal Diseases-require-Esophageal Neoplasms', 'Skin Neoplasms-diagnosed-Purpura', 'Hyperthyroidism-found-Hip Fractures', 'Neoplasms-considered-Microsatellite Instability', 'Hematoma-associated-Death', 'Death-associated-Hematoma', 'Hyperhomocysteinemia-identify-Atherosclerosis', 'Agnosia-examine-Alzheimer Disease', 'Infarction-present-Vertigo', 'Carcinoma, Hepatocellular-contribute-Carcinogenesis', 'Infections-treat-Enterocolitis, Pseudomembranous', 'Infections-used-Enterocolitis, Pseudomembranous', 'Carcinoma, Hepatocellular-cause-Infections', 'Colorectal Neoplasms-compare-Adenocarcinoma', 'Colorectal Neoplasms-examine-Adenocarcinoma', 'Gastrointestinal Hemorrhage-defined-Death', 'Dementia-applied-Alzheimer Disease', 'Dementia-applied-Dementia, Vascular', 'Heart Diseases-differ-Cerebral Infarction', 'Neoplasms-reported-Seminoma', 'Coronary Artery Disease-experience-Death, Sudden, Cardiac', 'Thyroid Neoplasms-obtained-Neoplasms', 'Arthritis-given-Heart Diseases', 'Arthritis-follow-Wounds and Injuries', 'Arthritis-given-Lung Diseases', 'Melanoma-increase-Neoplasms', 'Hypertension-produce-Death', 'Stomach Neoplasms-predict-Neoplasms', 'Death-attributed-Infections', 'Breast Neoplasms-started-Nijmegen Breakage Syndrome', "Dermatitis-complicate-Sjogren's Syndrome", "Dermatitis-show-Sjogren's Syndrome", 'Leukemia, Lymphocytic, Chronic, B-Cell-report-Death', 'Gallstones-associated-Death', 'Death-associated-Gallstones', 'Arrhythmias, Cardiac-differ-Cardiovascular Diseases', 'Neoplastic Syndromes, Hereditary-influence-Drug-Related Side Effects and Adverse Reactions', 'Headache Disorders, Secondary-include-Colonic Neoplasms', 'Weight Loss-associated-Isolated Noncompaction of the Ventricular Myocardium', 'Isolated Noncompaction of the Ventricular Myocardium-associated-Weight Loss', 'Spondylitis-result-Hematoma', 'Polyradiculopathy-result-Hematoma', 'Bacteriuria-defined-Death', 'Neoplasms-present-Rectal Neoplasms', 'Atrophy-associated-Stroke', 'Stroke-associated-Atrophy', 'Stroke-associated-Hip Fractures', 'Hip Fractures-associated-Stroke', 'Stroke-associated-Osteoarthritis', 'Osteoarthritis-associated-Stroke', 'Stroke-associated-Heart Diseases', 'Heart Diseases-associated-Stroke', 'Stroke-associated-Heart Failure', 'Heart Failure-associated-Stroke', 'Stroke-associated-Pulmonary Disease, Chronic Obstructive', 'Pulmonary Disease, Chronic Obstructive-associated-Stroke', 'Hypertension-slow-Carotid Stenosis', 'Hip Fractures-associated-Osteoarthritis', 'Osteoarthritis-associated-Hip Fractures', 'Hip Fractures-associated-Heart Failure', 'Heart Failure-associated-Hip Fractures', 'Acquired Immunodeficiency Syndrome-remain-HIV Infections', 'Aneurysm-cause-Neurologic Manifestations', 'Aneurysm-cause-Mastocytosis, Systemic', 'Cardiovascular Diseases-use-Glaucoma', 'Atrophy-associated-Memory Disorders', 'Memory Disorders-associated-Atrophy', 'Death-indicate-Tuberculosis', 'Hypercholesterolemia-alter-Hypertension', 'Lymphoma-focus-Death', 'Hypercholesterolemia-attenuate-Atherosclerosis', 'Breast Neoplasms-focus-Death', 'Multiple Myeloma-focus-Death', 'Melanoma-focus-Death', 'Ovarian Neoplasms-undergo-Uterine Cervical Neoplasms', 'Thyrotoxicosis-found-Hyperthyroidism', 'Calcinosis-attributed-Osteoporosis', 'Calcinosis-caused-Osteoporosis', 'Neoplasms-occur-Neoplasm Metastasis', 'Obesity-avoid-Death', 'Constriction, Pathologic-found-Hypertension', 'Obesity-avoid-Coronary Artery Disease', 'Pain-associated-Back Pain', 'Back Pain-associated-Pain', 'Angiodysplasia-considered-Gastrointestinal Hemorrhage', 'Dyskinesia, Drug-Induced-associated-Pinealoma', 'Pinealoma-associated-Dyskinesia, Drug-Induced', 'Glaucoma-caused-Uveitis', 'Pinealoma-increase-Dyskinesia, Drug-Induced', 'Hypertension-avoid-Ischemia', 'Spherocytosis, Hereditary-encompass-Genetic Diseases, Inborn', 'Weight Loss-associated-Coronary Artery Disease', 'Coronary Artery Disease-associated-Weight Loss', 'Weight Loss-cause-Coronary Artery Disease', 'Weight Loss-associated-Neoplasms', 'Neoplasms-associated-Weight Loss', 'Weight Loss-cause-Neoplasms', 'Weight Gain-associated-Coronary Artery Disease', 'Coronary Artery Disease-associated-Weight Gain', 'Weight Gain-associated-Neoplasms', 'Neoplasms-associated-Weight Gain', 'Cerebral Infarction-produce-Hemorrhage', 'Atrial Fibrillation-produce-Hemorrhage', 'Infections-include-Bacteriuria', 'Hypertension-offset-Stroke', 'Heart Diseases-underlie-Tachycardia, Supraventricular', 'Heart Diseases-underlie-Sick Sinus Syndrome', 'Diabetes Mellitus-rose-Communicable Diseases', 'Asthma-appear-Drug Hypersensitivity', 'Asthma-start-Pulmonary Disease, Chronic Obstructive', 'Death-increase-Prostatic Neoplasms', 'Neoplasms-increase-Prostatic Neoplasms', 'Quadriplegia-range-Neurodegenerative Diseases', 'Quadriplegia-range-Hyperostosis, Diffuse Idiopathic Skeletal', 'Quadriplegia-range-Spondylosis', 'Quadriplegia-range-Spondylitis, Ankylosing', 'Hypertrophy, Left Ventricular-caused-Cardiovascular Diseases', 'Stomach Neoplasms-derived-Neoplasms', 'Stomach Neoplasms-recorded-Death', 'Neutropenia-related-Psoriasis', 'Neutropenia-related-Arthritis, Rheumatoid', 'Fractures, Bone-show-Lactose Intolerance', 'Sleepiness-use-Sleep Deprivation', 'Stroke-complicate-Myocardial Infarction', 'Stroke-become-Arrhythmias, Cardiac', 'Ulcer-identify-Infections', 'Headache Disorders, Primary-confirm-Infarction', 'Coronary Artery Disease-confirm-Infarction', 'Foodborne Diseases-control-Infections', 'Hypercapnia-show-Thrombosis', 'Heart Failure-signify-Ventricular Fibrillation', 'Headache Disorders, Secondary-associated-Sleep Wake Disorders', 'Sleep Wake Disorders-associated-Headache Disorders, Secondary', 'Myoclonus-exercise-Hypertension', 'Myoclonus-exercise-Obesity', 'Myoclonus-exercise-Coronary Artery Disease', 'Sepsis-treated-Urinary Tract Infections', 'Sepsis-started-Cross Infection', 'Sepsis-treated-Infections', 'Sepsis-started-Infections', 'Sepsis-develop-Cross Infection', 'Infections-extenuate-Sinus Thrombosis, Intracranial', 'Urinary Tract Infections-started-Cross Infection', 'Urinary Tract Infections-started-Infections', 'Adenocarcinoma, Scirrhous-show-Stomach Diseases', 'TERC-result-Dyskeratosis Congenita', 'Urinary Tract Infections-acquired-Cross Infection', 'Infections-include-Cross Infection', 'Infections-started-Cross Infection', 'Infections-acquired-Cross Infection', 'INS-associated-Hypoglycemia', 'Hypoglycemia-associated-INS', 'Glucose-associated-Hypoglycemia', 'Hypoglycemia-associated-Glucose', 'GHRH-increased-Inositol', 'GHRH-increase-Inositol', 'Acarbose-rise-INS', 'Acarbose-rise-Hypotension', 'Obesity-associated-GIP', 'GIP-associated-Obesity', 'Glucose-increase-Diabetes Mellitus', 'Obesity-associated-Glucose', 'Glucose-associated-Obesity', 'Mannitol-up-regulate-CAT', 'INS-base-Glucose', 'INS-reduce-Glucose', 'INS-base-Congenital Hyperinsulinism', 'Necrosis-sulfated-Glycosaminoglycans', 'Osteoarthritis-cultured-Alginates', 'Diabetes Mellitus-pertain-INS', 'Diabetes Mellitus-pertain-Glucose', 'INS-induced-Glucose', 'Glucose-decrease-INS', 'GCKR-play-Glucose Metabolism Disorders', 'rs1260326-associated-Glucose', 'Glucose-associated-rs1260326', 'rs1260326-associated-Triglycerides', 'Triglycerides-associated-rs1260326', 'SIRT1-induced-Glucose', 'Digoxin-compare-CST3', 'INS-increased-Diabetes Mellitus', 'Sugars-related-INS', 'Glucose-increased-Diabetes Mellitus', 'MLXIPL-respond-Sugars', 'Diabetes Mellitus-related-INS', 'Diabetes Mellitus-related-Glucose', 'Diabetes Mellitus-produce-INS', 'INS-predict-Glucose', 'INS-reflected-Glucose', 'INS-predict-Glucose Intolerance', 'Glucose Intolerance-predict-Glucose', 'FGF21-associated-Glucose', 'Glucose-associated-FGF21', 'Eicosapentaenoic Acid-inhibit-SIRT1', 'Diabetes Mellitus-undergo-Glucose', 'INS-measure-Glucose', 'ADIPOQ-decrease-Glucose', 'ADIPOQ-decrease-Cardiovascular Diseases', 'ADIPOQ-associated-Glucose', 'Glucose-associated-ADIPOQ', 'SLC5A2-manage-Diabetes Mellitus', 'INS-reduce-Hyperglycemia', 'Canagliflozin-manage-Diabetes Mellitus', 'Glucose-reduce-Hyperglycemia', 'INS-calculated-Glucose', 'Canagliflozin-belong-SLC5A2', 'Canagliflozin-belong-Hypoglycemia', 'Glucose-used-INS', 'Glucose Metabolism Disorders-used-INS', 'GCG-elevated-Diabetes Mellitus', 'Glucosamine-identify-NOX4', 'Glucose-elevated-Diabetes Mellitus', 'Glucosamine-identify-Hepatic Encephalopathy', 'FGF21-play-Glucose', 'GCK-facilitate-Glucose', 'APOB-include-Cardiovascular Diseases', 'Glucose-include-Cardiovascular Diseases', 'Glucose Intolerance-involve-INS', 'Glucose Intolerance-involve-Glucose', 'INS-determined-Glucose', 'VDR-associated-Fibrosis', 'Fibrosis-associated-VDR', 'GGH-associated-Eicosapentaenoic Acid', 'Eicosapentaenoic Acid-associated-GGH', 'Capsaicin-elevate-SIRT1', 'Fatty Acids, Unsaturated-associated-INS', 'INS-associated-Fatty Acids, Unsaturated', 'Fatty Acids, Unsaturated-associated-Glucose Metabolism Disorders', 'Glucose Metabolism Disorders-associated-Fatty Acids, Unsaturated', 'MLXIPL-protect-Triglycerides', 'IGF1-associated-Triglycerides', 'Triglycerides-associated-IGF1', 'IGF1-associated-Metabolic Syndrome', 'Metabolic Syndrome-associated-IGF1', 'Triglycerides-linked-INS', 'INS-remain-Weight Loss', 'CYP2D6-treated-Venlafaxine Hydrochloride', 'Cholecalciferol-decrease-KL', 'ADIPOQ-decrease-Progeria', 'Cholesterol-decrease-Progeria', 'CD4-infected-Atorvastatin', 'Ischemia-studied-KNG1', 'FABP2-involved-Fatty Acids', 'Ischemia-studied-Epoprostenol', 'APOB-contain-Atherosclerosis', 'Cholesterol-contain-Atherosclerosis', 'NR3C1-modify-Cholesterol', 'Atorvastatin-produce-CRP', 'CD4-induce-HIV Infections', 'SELENOP-distribute-Glutathione', 'APOE-associated-Cholesterol', 'Cholesterol-associated-APOE', 'GSTM1-affect-Glutathione', 'Ghrelin-stimulate-GGH', 'APOE-stratified-Checkpoint Kinase 1', 'Nivolumab-establish-VEGFA', 'PTH-associated-Infliximab', 'Infliximab-associated-PTH', 'Fractures, Bone-genotyped-NR3C1', 'KL-associated-Hypertension', 'Hypertension-associated-KL', 'rs9536314-associated-Hypertension', 'Hypertension-associated-rs9536314', 'COL2A1-associated-Scoliosis', 'Scoliosis-associated-COL2A1', 'ADAM12-associated-Osteoarthritis', 'Osteoarthritis-associated-ADAM12', 'ADAM12-used-Osteoarthritis', 'rs3740199-used-Osteoarthritis', 'rs2276454-associated-Scoliosis', 'Scoliosis-associated-rs2276454', 'rs3740199-associated-Osteoarthritis', 'Osteoarthritis-associated-rs3740199', 'rs13038305-tend-CST3', 'rs13038305-associated-CST3', 'CST3-associated-rs13038305', 'rs13038305-associated-Renal Insufficiency, Chronic', 'Renal Insufficiency, Chronic-associated-rs13038305', 'GBA-lead-Parkinson Disease', 'rs13038305-explain-CST3', 'NOTCH3-account-Cerebral Hemorrhage', 'LMNA-associated-Diabetes Mellitus, Type 2', 'Diabetes Mellitus, Type 2-associated-LMNA', 'LMNA-impact-Diabetes Mellitus, Type 2', 'rs201118034-account-Cerebral Hemorrhage', 'rs4641-associated-Diabetes Mellitus, Type 2', 'Diabetes Mellitus, Type 2-associated-rs4641', 'rs4641-impact-Diabetes Mellitus, Type 2', 'Cerebral Hemorrhage-carry-NOTCH3', 'Cerebral Hemorrhage-carry-rs201118034', 'VDR-associated-rs1544410', 'rs1544410-associated-VDR', 'TERT-assessed-Atrial Fibrillation', 'rs2736100-assessed-Atrial Fibrillation', 'rs2802292-associated-FOXO3', 'FOXO3-associated-rs2802292', 'FOXO3-associated-Chemical and Drug Induced Liver Injury', 'Chemical and Drug Induced Liver Injury-associated-FOXO3', 'rs2802292-associated-Chemical and Drug Induced Liver Injury', 'Chemical and Drug Induced Liver Injury-associated-rs2802292', 'rs1799941-associated-SHBG', 'SHBG-associated-rs1799941', 'rs751713049-include-SRSF2', 'ABCB1-predict-Renal Insufficiency, Chronic', 'rs1045642-predict-Renal Insufficiency, Chronic', 'IL6R-associated-Atrial Fibrillation', 'Atrial Fibrillation-associated-IL6R', 'rs2802292-characterize-FOXO3', 'rs2802292-type-Peutz-Jeghers Syndrome', 'IDO1-related-Cataract', 'rs4613984-related-Cataract', 'ABCA7-associated-Alzheimer Disease', 'Alzheimer Disease-associated-ABCA7', 'rs3764-associated-Alzheimer Disease', 'Alzheimer Disease-associated-rs3764', 'Alzheimer Disease-genotyped-ABCA7', 'TACR3-associated-Headache Disorders, Secondary', 'Headache Disorders, Secondary-associated-TACR3', 'rs2066479-investigate-HSD17B3', 'rs2066479-replaced-HSD17B3', 'rs74827081-associated-Headache Disorders, Secondary', 'Headache Disorders, Secondary-associated-rs74827081', 'HSD17B3-investigate-Prostatic Neoplasms', 'rs2066479-investigate-Prostatic Neoplasms', 'LMNA-associated-Progeria', 'Progeria-associated-LMNA', 'F5-predispose-Venous Thrombosis', 'rs1207568-associated-Hypertension', 'Hypertension-associated-rs1207568', 'PON1-associated-Alzheimer Disease', 'Alzheimer Disease-associated-PON1', 'rs662-associated-Alzheimer Disease', 'Alzheimer Disease-associated-rs662', 'rs10149146-lie-TECPR2', 'MMP12-associated-Asthma', 'Asthma-associated-MMP12', 'rs2276109-associated-Asthma', 'Asthma-associated-rs2276109', 'ABCG2-associated-Hyperuricemia', 'Hyperuricemia-associated-ABCG2', 'rs2231142-associated-Hyperuricemia', 'Hyperuricemia-associated-rs2231142', 'ABCG2-reinforce-Hyperuricemia', 'rs2231143-reinforce-Hyperuricemia', 'FGB-associate-Stroke', 'Stroke-associate-FGB', 'XRCC4-associated-Endometriosis', 'Endometriosis-associated-XRCC4', 'Neoplasms-used-BRCA2', 'PSEN2-associated-Parkinson Disease', 'Parkinson Disease-associated-PSEN2', 'rs75733498-associated-Parkinson Disease', 'Parkinson Disease-associated-rs75733498', 'SIRT1-implicated-Diabetes Mellitus', 'SIRT1-associated-Kidney Diseases', 'Kidney Diseases-associated-SIRT1', 'Diabetes Mellitus-use-INS', 'TREM2-confer-Alzheimer Disease', 'BMI1-confer-Alzheimer Disease', 'Immunologic Deficiency Syndromes-lead-CRP', 'DNASE1-damage-Neoplasms', 'EFEMP1-associated-Alzheimer Disease', 'Alzheimer Disease-associated-EFEMP1', 'AMH-compare-Neoplasms', 'Hypertension-linked-KCNA3', 'ERBB2-amplified-Breast Neoplasms', 'KLK3-diagnosed-Prostatic Hyperplasia', 'KLK3-used-Prostatic Neoplasms', 'KLK3-associated-Prostatic Neoplasms', 'Prostatic Neoplasms-associated-KLK3', 'COL17A1-suggest-Stroke', 'WRN-cause-Werner Syndrome', 'PRKAA2-improve-Osteoarthritis', 'APOE-determined-Myocardial Infarction', 'LCN2-increase-Diabetes Mellitus, Type 2', 'Diabetes Mellitus-predicted-SHBG', 'CISD2-related-Mitochondrial Diseases', 'CISD2-span-Mitochondrial Diseases', 'SYP-determine-Metabolic Syndrome', 'SLC12A1-explain-Dehydration', 'CLEC4M-studied-Arbovirus Infections', 'CRP-known-Cardiovascular Diseases', 'Alzheimer Disease-layer-APOE', 'SHBG-reflect-Ovarian Diseases', 'DPP4-approved-Diabetes Mellitus, Type 2', 'CRP-associated-Atherosclerosis', 'Atherosclerosis-associated-CRP', 'FOXO1-implicated-Osteoarthritis', 'VEGFA-assess-Rheumatic Diseases', 'VDR-associated-Death', 'Death-associated-VDR', 'VDR-translate-Death', 'CRP-calculated-Stomach Neoplasms', 'COL2A1-investigated-Scoliosis', 'CRP-associated-Macular Degeneration', 'Macular Degeneration-associated-CRP', 'CTSB-describe-Neoplasms', 'Acute Kidney Injury-predict-LCN2', 'AGER-associated-Anemia', 'Anemia-associated-AGER', 'LEP-correlate-Obesity', 'FMR1-investigate-Infertility, Female', 'Bone Neoplasms-associated-PTH', 'PTH-associated-Bone Neoplasms', 'LEP-associated-Obesity', 'Obesity-associated-LEP', 'Critical Illness-include-ALB', 'Fibrosis-increase-GGH', 'Hemorrhage-reduced-F8', 'Renal Insufficiency, Chronic-correlated-ALB', 'HIV Infections-characterized-CD4', 'DUSP22-facilitate-Skin Neoplasms', 'Hyperparathyroidism-stimulate-PTH', 'CRP-measured-Aneurysm', 'Skin Neoplasms-transfected-DUSP22', 'PTH-performed-Hypocalcemia', 'Atrial Fibrillation-show-CCN2', 'Acute Coronary Syndrome-carry-CYP2C19', 'INS-measured-Glucose Metabolism Disorders', 'Hypoxia-lead-INS', 'GPT-identify-Death', 'NPPA-correlate-Mitral Valve Stenosis', 'CST3-proposed-Renal Insufficiency, Chronic', 'GPX3-protect-Thrombosis', 'APOE-compared-Cerebral Hemorrhage', 'SIRT1-protect-Death', 'AR-stimulate-Prostatic Neoplasms', 'ALB-identify-Death', 'TP53-lead-Pulmonary Disease, Chronic Obstructive', 'INS-tolerated-Diabetes Mellitus', 'LEP-associated-HIV Infections', 'HIV Infections-associated-LEP', 'AMH-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-AMH', 'LEP-include-Alzheimer Disease', 'FGF23-linked-Cardiovascular Diseases', 'SIRT1-established-Breast Neoplasms', 'Inflammation-reflect-IL6', 'MAPT-manifest-Alzheimer Disease', 'TNF-implicated-Rheumatic Diseases', 'SPP1-increased-Hip Fractures', 'INS-associated-Death', 'Death-associated-INS', 'Diabetes Mellitus, Type 2-prescribe-INS', 'LRRK2-resemble-Parkinson Disease', 'CRP-predict-Dementia', 'Neoplasms-assessed-CDKN2A', 'Stroke-include-APOE', 'Renal Insufficiency, Chronic-report-CST3', 'S100A3-related-Muscle Rigidity', 'CRP-diagnose-Pneumonia', 'Weight Loss-improve-INS', 'Cardiac Output, Low-differ-APOE', 'PARP1-affected-Autoimmune Diseases', 'PARP1-described-Autoimmune Diseases', 'EGFR-correlate-Neoplasms', 'Dementia-associated-AIF1', 'AIF1-associated-Dementia', 'WRN-associated-Breast Neoplasms', 'Breast Neoplasms-associated-WRN', 'Pain-suppress-AVP', 'CYP3A4-associated-Prostatic Neoplasms', 'Prostatic Neoplasms-associated-CYP3A4', 'TOMM40-affected-Alzheimer Disease', "Sjogren's Syndrome-associate-GNL3", "GNL3-associate-Sjogren's Syndrome", 'MUC1-used-Lung Diseases', 'LRRTM3-associated-Alzheimer Disease', 'Alzheimer Disease-associated-LRRTM3', 'Neoplasms-associated-KLK3', 'KLK3-associated-Neoplasms', 'IL1B-increased-Alzheimer Disease', 'Diabetes Mellitus-receive-INS', 'Renal Insufficiency, Chronic-use-CST3', 'Werner Syndrome-associated-LMNA', 'LMNA-associated-Werner Syndrome', 'TNF-associated-Heart Failure', 'Heart Failure-associated-TNF', 'SAR1B-associated-Alzheimer Disease', 'Alzheimer Disease-associated-SAR1B', 'CRP-operated-Hip Fractures', 'ESR1-affect-Alzheimer Disease', 'ADIPOQ-decrease-Death', 'ALDH2-use-Neoplasms', 'Pulpitis-show-ALPP', 'MAPT-correlated-Memory Disorders', 'INS-initiated-Dyskinesias', 'H2AX-assessed-Pulmonary Disease, Chronic Obstructive', 'ALB-distinguish-Sarcopenia', 'EFEMP1-reduced-Osteoarthritis', 'S100A9-found-Parkinson Disease', 'CLDN5-associated-Alzheimer Disease', 'Alzheimer Disease-associated-CLDN5', 'Leukemia, Myeloid, Acute-found-NPM1', 'CCND1-comprise-Necrosis', 'Tachycardia, Atrioventricular Nodal Reentry-reflect-PGR', 'CRP-associated-Stroke', 'Stroke-associated-CRP', 'FMR1-associate-Primary Ovarian Insufficiency', 'Primary Ovarian Insufficiency-associate-FMR1', 'PTN-induce-Brain Ischemia', 'Seizures-associated-KL', 'KL-associated-Seizures', 'SHBG-associated-Diabetes Mellitus, Type 2', 'Diabetes Mellitus, Type 2-associated-SHBG', 'AGER-expressed-IgA Vasculitis', 'Leukemia, Myeloid, Acute-observed-ABCB1', 'SIRT1-reduced-Atherosclerosis', 'NEFL-indicate-Basal Ganglia Diseases', 'Mitochondrial Diseases-result-COQ7', 'Acromegaly-lead-INS', 'CDC26-represent-Chromosome Aberrations', 'CLU-show-Ossification of Posterior Longitudinal Ligament', 'MAPT-performed-Alzheimer Disease', 'CCL2-involved-Alzheimer Disease', 'PAX3-distinguish-Rhabdomyosarcoma', 'Renal Insufficiency, Chronic-affected-CST3', 'APOE-investigate-Cerebral Amyloid Angiopathy', 'WRN-follow-Carcinoma, Squamous Cell', 'WRN-increased-Carcinoma, Squamous Cell', 'LEP-mediate-Narcolepsy', 'MFAP4-evaluate-Diabetes Mellitus', 'Stomach Neoplasms-undergo-EREG', 'SIRT1-improved-Sleep Apnea, Obstructive', 'Glucose Intolerance-measured-PROM1', 'ESR2-affect-Alzheimer Disease', 'NFE2L2-enhance-Alzheimer Disease', 'Diabetes Mellitus-reimbursed-INS', 'CST3-associated-Peripheral Arterial Disease', 'Peripheral Arterial Disease-associated-CST3', 'Sleep Apnea, Obstructive-restore-SIRT1', 'SPP1-correlated-Kidney Calculi', 'CRH-associated-Polymyalgia Rheumatica', 'Polymyalgia Rheumatica-associated-CRH', 'KL-predict-Cardiovascular Diseases', 'COL18A1-associated-Albuminuria', 'Albuminuria-associated-COL18A1', 'KL-obtained-Renal Insufficiency, Chronic', 'ADIPOQ-associated-Dementia', 'Dementia-associated-ADIPOQ', 'Infections-compared-ALB', 'CD8A-identify-HIV Infections', 'TNFRSF1A-underlie-Inflammation', 'ALB-associated-Ataxia', 'Ataxia-associated-ALB', 'Diabetes Mellitus-focus-INS', 'INS-substitute-Diabetes Mellitus, Type 2', 'CCND1-characterize-Neoplasms', 'CCND1-strengthen-Neoplasms', 'CCND1-seen-Neoplasms', 'CDKN2A-result-Hypertension', 'Acquired Immunodeficiency Syndrome-assessed-CD4', 'Genetic Diseases, Inborn-caused-ABCC6', 'Infections-attenuate-TFF2', 'ADIPOQ-associated-Death', 'Death-associated-ADIPOQ', 'PPIA-involved-Infections', 'CRP-evaluate-Communicable Diseases', 'CRP-predict-Cerebral Infarction', 'LRRK2-account-Parkinson Disease', 'AMH-emerge-Ovarian Diseases', 'Seizures-produce-RGN', 'LEP-increased-Diabetes Mellitus', 'GLO1-reduced-Carotid Artery Diseases', 'GLO1-studied-Atherosclerosis', 'APOE-associated-Fractures, Bone', 'Fractures, Bone-associated-APOE', 'ACE-underused-Kidney Diseases', 'LEP-show-Obesity', 'LEP-cause-Weight Loss', 'INS-receive-Diabetes Mellitus', 'NINJ2-associated-Stroke', 'Stroke-associated-NINJ2', 'SERPINA12-increase-Glucose Metabolism Disorders', 'BMI1-Determine-Corneal Diseases', 'CCL11-exert-Metabolic Diseases', 'DNER-assessed-Pulmonary Disease, Chronic Obstructive', 'CRP-related-Hypertension', 'DNER-reveal-Pulmonary Disease, Chronic Obstructive', 'DNER-localised-Pulmonary Disease, Chronic Obstructive', 'DNER-induced-Pulmonary Disease, Chronic Obstructive', 'CRP-seem-Atherosclerosis', 'KL-involved-Inflammation', 'ACHE-decreased-Alzheimer Disease', 'INSR-associated-AIDS Arteritis, Central Nervous System', 'AIDS Arteritis, Central Nervous System-associated-INSR', 'GBA-associated-Lewy Body Disease', 'Lewy Body Disease-associated-GBA', 'CRP-remain-Neoplasms', 'GBA-found-Alzheimer Disease', 'GBA-associated-Alzheimer Disease', 'Alzheimer Disease-associated-GBA', 'CST3-show-Renal Insufficiency, Chronic', 'CST3-define-Renal Insufficiency, Chronic', 'BGLAP-associated-Obesity', 'Obesity-associated-BGLAP', 'Obesity-reduced-INS', 'Seizures-include-INS', 'IL6-associated-Coronary Artery Disease', 'Coronary Artery Disease-associated-IL6', 'HIV Infections-started-CD4', 'PGF-found-Pre-Eclampsia', 'Alzheimer Disease-reflect-MAPT', 'MPO-associated-Glomerulonephritis', 'Glomerulonephritis-associated-MPO', 'MTOR-include-Osteoarthritis', 'DDIT4-reduce-Osteoarthritis', 'Alzheimer Disease-stratified-APOE', 'Alzheimer Disease-accord-APOE', 'Renal Insufficiency, Chronic-estimate-EGFR', 'MAPT-change-Alzheimer Disease', 'PTHLH-assessed-Neoplasms', 'CRP-enhance-Cardiovascular Diseases', 'SIRT6-exert-Cerebral Infarction', 'FNDC5-use-Myocardial Infarction', 'MKX-decreased-Osteoarthritis', 'Seizures-improve-INS', 'TF-enhanced-Inflammation', 'SIRT1-decreased-Atherosclerosis', 'COL18A1-associated-Death', 'Death-associated-COL18A1', 'AGER-associated-Inflammation', 'Inflammation-associated-AGER', 'MAPT-measured-Neurodegenerative Diseases', 'FGF23-implicated-Cardiovascular Diseases', 'IL6-used-Dementia', 'AR-reveal-Myelodysplastic Syndromes', 'Infertility, Female-investigate-FMR1', 'Infertility, Female-correlate-FMR1', 'PLIN2-modulated-Neurodegenerative Diseases', 'AMH-measured-Amenorrhea', 'PTGER4-serve-Aortic Aneurysm, Abdominal', 'Death-modulate-MAPK14', 'CRP-presented-Diverticulitis', 'IL6-determined-Sarcopenia', 'APOE-spe-Diabetic Nephropathies', 'Inflammation-tend-APOE', 'ACAN-reduced-Cartilage Diseases', 'MSTN-proposed-Sarcopenia', 'Glycogen Storage Disease Type II-comprise-VEGFA', 'Glycogen Storage Disease Type II-undergo-VEGFA', 'SIRT3-counteract-Mitochondrial Diseases', 'TP53-minimize-Neoplasms', 'ADIPOQ-increased-Obesity', 'FAM83H-demonstrate-Hantavirus Pulmonary Syndrome', 'MAPT-associated-Dementia', 'Dementia-associated-MAPT', 'INS-induce-Sialic Acid Storage Disease', 'CDKN2B-associated-Myelodysplastic Syndromes', 'Myelodysplastic Syndromes-associated-CDKN2B', 'ESR1-increase-Diabetes Mellitus, Type 2', 'CDKN2B-performed-Myelodysplastic Syndromes', 'Multiple Sclerosis-show-KCNJ10', 'Alzheimer Disease-trigger-MAPT', 'APOE-receive-Alzheimer Disease', 'IGF1-influence-Cardiovascular Diseases', 'ELN-include-Urinary Incontinence, Stress', 'MEOX2-treat-Urinary Incontinence', 'CTLA4-used-Neoplasms', 'KLK3-detect-Prostatic Neoplasms', 'UCP2-show-Hearing Loss, Sudden', 'CRP-regulate-Inflammation', 'Aortic Diseases-associated-INS', 'INS-associated-Aortic Diseases', 'Dementia-phosphorylate-MAPT', 'Cerebral Small Vessel Diseases-associated-MAPT', 'MAPT-associated-Cerebral Small Vessel Diseases', 'AHR-linked-Diabetes Mellitus', 'Inflammation-examine-CRP', 'Inflammation-assess-CRP', 'GH1-determined-Arthritis, Rheumatoid', 'SERPINB5-identify-Neoplasms', 'Arbovirus Infections-occur-TLR7', 'Peptic Ulcer-take-PTGS2', 'SERPINB5-determined-Neoplasms', 'MTOR-identified-Neoplasms', 'CASR-predict-Death', 'MTOR-obtained-Endometrial Neoplasms', 'Rhabdomyolysis-associated-CYP3A4', 'CYP3A4-associated-Rhabdomyolysis', 'Optic Nerve Glioma-involve-MGMT', 'Retinal Degeneration-associated-FMOD', 'FMOD-associated-Retinal Degeneration', 'Infections-reflect-CRP', 'Rhabdomyolysis-provide-CYP3A4', 'ELN-result-Skin Diseases', 'SHBG-measured-Hypogonadism', 'CST3-associated-Metabolic Syndrome', 'Metabolic Syndrome-associated-CST3', 'APLN-proposed-Sarcopenia', 'Amyloidosis-caused-TTR', 'NEFL-increase-Alzheimer Disease', 'PRL-measured-Sepsis', 'WRN-associated-Cerebral Infarction', 'Cerebral Infarction-associated-WRN', 'HOXA4-associated-Aortic Aneurysm, Abdominal', 'Aortic Aneurysm, Abdominal-associated-HOXA4', 'RPE-observed-Anophthalmos', 'CCN4-play-Osteoarthritis', 'SIRT7-demonstrate-Ovarian Neoplasms', 'CCL2-associated-Hearing Loss', 'Hearing Loss-associated-CCL2', 'LRP5-associated-Muscular Dystrophy, Duchenne', 'Muscular Dystrophy, Duchenne-associated-LRP5', 'CCN4-reported-Osteoarthritis', 'Cardiomyopathy, Dilated-immunostained-NAMPT', 'Cardiovascular Diseases-measure-APOE', 'IGF1-play-Alzheimer Disease', 'IGF1-involved-Acromegaly', 'NINJ2-associated-Cerebral Infarction', 'Cerebral Infarction-associated-NINJ2', 'Anemia-interact-EPO', 'INS-accelerated-Glucose Intolerance', 'Glucose Metabolism Disorders-improve-INS', 'PON1-related-Stroke', 'FMR1-associated-Primary Ovarian Insufficiency', 'Primary Ovarian Insufficiency-associated-FMR1', 'PTH-obtained-Heart Failure', 'ADIPOQ-identified-Diabetes Mellitus, Type 2', 'CXCR1-associated-Pulmonary Disease, Chronic Obstructive', 'Pulmonary Disease, Chronic Obstructive-associated-CXCR1', 'Neoplasms-associated-SIRT2', 'SIRT2-associated-Neoplasms', 'IGF1R-observed-Carcinoma, Squamous Cell', 'PTH-measured-Osteoarthritis', 'NEFL-released-Nerve Degeneration', 'NGF-compare-Urinary Bladder, Overactive', 'NGF-correlate-Urinary Bladder, Overactive', 'MPO-treat-Erectile Dysfunction', 'KLK3-obtained-Prostatic Diseases', 'AMH-associated-Aneuploidy', 'Aneuploidy-associated-AMH', 'KL-measured-Dwarfism, Pituitary', 'KL-increase-Dwarfism, Pituitary', 'PGR-include-Neoplasms', 'LCN2-gain-Chronic Disease', 'FABP2-associated-Hearing Loss', 'Hearing Loss-associated-FABP2', 'AMH-explained-Polycystic Ovary Syndrome', 'EZR-associated-Neurodegenerative Diseases', 'Neurodegenerative Diseases-associated-EZR', 'SHBG-associated-Death', 'Death-associated-SHBG', 'Parkinson Disease-modify-SHBG', 'Sleep Initiation and Maintenance Disorders-associated-CD8A', 'CD8A-associated-Sleep Initiation and Maintenance Disorders', 'MUC1-provided-Mouth Diseases', 'KL-act-Neoplasms', 'SIRT1-reduced-Diabetes Mellitus', 'KL-associated-Parkinson Disease', 'Parkinson Disease-associated-KL', 'APOE-diagnosed-Alzheimer Disease', 'TERT-reported-Thyroid Cancer, Papillary', 'ESR1-identify-Muscular Dystrophy, Duchenne', 'IGF1-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-IGF1', 'Inflammation-investigate-CRP', 'APOE-linked-Dementia', 'TNFRSF11B-associated-Metabolic Syndrome', 'Metabolic Syndrome-associated-TNFRSF11B', 'KL-linked-Hypertrophy', 'Breast Neoplasms-constructed-TP53', 'Breast Neoplasms-stain-TP53', 'Bronchial Neoplasms-used-AGER', 'Bronchial Neoplasms-investigate-AGER', 'Heart Failure-predict-REN', 'MIB1-use-Pituitary Neoplasms', 'ADIPOQ-influence-Coronary Artery Disease', 'ADIPOQ-associated-Coronary Artery Disease', 'Coronary Artery Disease-associated-ADIPOQ', 'CD4-include-HIV Infections', 'INS-enhance-Glucose Intolerance', 'CFAP97-isolated-Cataract', 'GGTLC3-result-Coronary Artery Disease', 'CRP-account-Arthritis', 'INS-confer-Glucose Metabolism Disorders', 'CYP19A1-affect-Alzheimer Disease', 'INS-improved-Polycystic Ovary Syndrome', 'ACE-report-Urinary Bladder, Overactive', 'Alzheimer Disease-associated-CHAT', 'CHAT-associated-Alzheimer Disease', 'CHAT-occur-Alzheimer Disease', 'CST3-associated-Cerebral Infarction', 'Cerebral Infarction-associated-CST3', 'ITGAM-associated-Death', 'Death-associated-ITGAM', 'INS-measured-Diabetes Mellitus', 'CD4-established-HIV Infections', 'TNFRSF11B-associated-Kidney Diseases', 'Kidney Diseases-associated-TNFRSF11B', 'Leukemia, Myelomonocytic, Chronic-recruit-SRSF2', 'Alzheimer Disease-reduce-MAPT', 'KL-associated-Kidney Diseases', 'Kidney Diseases-associated-KL', 'FNDC5-used-Sarcopenia', 'ADIPOQ-impact-Alzheimer Disease', 'FNDC5-evaluate-Sarcopenia', 'APOE-increase-Cerebral Infarction', 'INS-linked-Chronic Disease', 'Glucose Metabolism Disorders-related-MAPT', 'CD79A-appear-Death', 'APOE-report-Alzheimer Disease', 'INS-associated-Obesity, Abdominal', 'Obesity, Abdominal-associated-INS', 'EGFR-harbor-Carcinoma, Squamous Cell', 'DDAH2-associate-Erectile Dysfunction', 'Erectile Dysfunction-associate-DDAH2', 'Ovarian Neoplasms-show-WFDC2', 'KL-associated-Dementia', 'Dementia-associated-KL', 'Carcinoma, Non-Small-Cell Lung-affected-EGFR', 'SHBG-associated-Peripheral Arterial Disease', 'Peripheral Arterial Disease-associated-SHBG', 'BDNF-known-Nerve Degeneration', 'GIP-involved-Diabetes Mellitus', 'IL6-associated-Psychomotor Disorders', 'Psychomotor Disorders-associated-IL6', 'HHLA2-serve-Neoplasms', 'SIRT1-elevated-Asthma', 'HHLA2-predict-Neoplasms', 'ITLN1-related-Diabetic Neuropathies', 'APOE-rated-Epilepsy, Temporal Lobe', 'SIRT1-quantified-Asthma', 'MAPT-fail-HIV Infections', 'AGER-coincide-Macular Degeneration', 'Lung Neoplasms-connect-CD4', 'FGF23-associated-Cerebral Small Vessel Diseases', 'Cerebral Small Vessel Diseases-associated-FGF23', 'FGF23-associated-Dementia', 'Dementia-associated-FGF23', 'APOE-altered-Alzheimer Disease', 'SHBG-involved-Coronary Artery Disease', 'INS-delivered-Alzheimer Disease', 'SHBG-calculated-Coronary Artery Disease', 'HIV Infections-stratified-CD4', 'HLA-DRB1-suffer-Carcinoma, Hepatocellular', 'Diabetes Mellitus-decreased-REN', 'APOE-found-Alzheimer Disease', 'Corneal Diseases-down-regulated-CISD2', 'GGH-associated-Sarcopenia', 'Sarcopenia-associated-GGH', 'Genetic Diseases, Inborn-associated-LMNA', 'LMNA-associated-Genetic Diseases, Inborn', 'AMH-considered-Ovarian Diseases', 'AMH-reflect-Ovarian Diseases', 'Diabetes Mellitus-involve-INS', 'KLK3-utilized-Prostatic Neoplasms', 'Diabetes Mellitus-treated-INS', 'Glaucoma-determine-YAP1', 'INS-affect-Brain Diseases, Metabolic', 'Fever-improve-CRP', 'Gastrointestinal Stromal Tumors-show-KIT', 'GRN-promote-Neoplasms', 'Diabetes Mellitus-require-INS', 'INS-use-Diabetes Mellitus', 'CCND2-detected-Ovarian Diseases', 'Ovarian Diseases-measured-CCND2', 'Asthenozoospermia-show-PGK2', 'TERT-chosen-Neoplasms', 'NDRG2-regulated-Cataract', 'Renal Insufficiency, Chronic-measured-KL', 'GSR-differ-Periodontitis', 'INS-associated-Hypertension', 'Hypertension-associated-INS', 'SFRP5-implicated-Cardiovascular Diseases', 'PTX3-associated-Obesity', 'Obesity-associated-PTX3', 'CTTN-play-Neoplasms', 'NOS1-lead-Ischemia', 'LCT-associated-Fractures, Bone', 'Fractures, Bone-associated-LCT', 'MGLL-assessed-Alzheimer Disease', 'IL17A-compare-Atrial Fibrillation', 'IL17A-related-Atrial Fibrillation', 'SIRT1-associated-Glucose Metabolism Disorders', 'Glucose Metabolism Disorders-associated-SIRT1', 'SIRT1-improve-Glucose Metabolism Disorders', 'FABP3-used-Heart Diseases', 'TNF-associated-Infections', 'Infections-associated-TNF', 'Coronary Artery Disease-lead-CD8A', 'ACE-associated-Dementia', 'Dementia-associated-ACE', 'TCN2-associated-Peripheral Nervous System Diseases', 'Peripheral Nervous System Diseases-associated-TCN2', 'EPO-increased-Hypoxia', 'Inflammation-improve-INS', 'SOST-involved-Osteoporosis', 'NEFL-elevated-Alzheimer Disease', 'IL6R-identify-Atrial Fibrillation', 'NFE2L2-ameliorated-Pigmentation Disorders', 'IAPP-identified-Diabetes Mellitus', 'RRM1-improve-Carcinoma, Non-Small-Cell Lung', 'AMH-proposed-Ovarian Diseases', 'Hypertrophy-accompanied-VEGFA', 'APOE-affect-Dementia', 'CRP-establish-Appendicitis', 'VEGFA-increased-Hypertrophy', 'SHBG-associated-Hepatitis C', 'Hepatitis C-associated-SHBG', 'INS-compare-Metabolic Syndrome', 'Inflammation-signified-ITGAM', 'MTHFR-associated-Hearing Loss', 'Hearing Loss-associated-MTHFR', 'Dementia-involve-MAPT', 'CRP-underlie-Neoplasms', 'Hypothalamic Neoplasms-exhibit-GGH', 'Pituitary Diseases-defined-GGH', 'Atrial Fibrillation-associated-IL6', 'IL6-associated-Atrial Fibrillation', 'ATF4-activate-Muscular Atrophy', 'BRAF-increased-Thyroid Cancer, Papillary', 'CD1D-expressed-Leukemia, Lymphocytic, Chronic, B-Cell', 'HIV Infections-recommended-CD4', 'CCR5-benefit-Heart Failure', 'Heart Failure-measured-IGFBP7', 'IGFBP7-associated-Obesity', 'Obesity-associated-IGFBP7', 'DPP4-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-DPP4', 'ADAR-associated-Atherosclerosis', 'Atherosclerosis-associated-ADAR', 'ADARB2-associated-Metabolic Diseases', 'Metabolic Diseases-associated-ADARB2', 'Alzheimer Disease-remain-APOE', 'HIV Infections-diagnosed-CD4', 'BSG-increase-Stroke', 'FNDC5-associated-Coronary Artery Disease', 'Coronary Artery Disease-associated-FNDC5', 'CST3-possess-Renal Insufficiency, Chronic', 'AMH-associated-Infertility, Female', 'Infertility, Female-associated-AMH', 'CDK6-expressed-Stomach Neoplasms', 'BRCA2-carry-Hereditary Breast and Ovarian Cancer Syndrome', 'Dementia-defined-APOE', 'ADIPOQ-increased-Heart Failure', 'BGLAP-evaluate-Osteoporotic Fractures', 'Neoplasms-overcome-TNFSF10', 'SIRT6-expressed-Cartilage Diseases', 'Hyperinsulinism-improve-INS', 'ACE-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-ACE', 'STAT3-involved-Sclerosis', 'Infections-obtained-CRP', 'APOE-confer-Dementia', 'Hemorrhage-evaluate-APOE', 'CFH-associated-Glycogen Storage Disease Type II', 'Glycogen Storage Disease Type II-associated-CFH', 'Cachexia-exhibit-FGF21', 'THBS1-compare-Hypertension', 'CBS-used-Cerebral Infarction', 'CHI3L1-up-regulated-Neoplasms', 'CRP-associate-Cardiovascular Diseases', 'Cardiovascular Diseases-associate-CRP', 'USP22-play-Retinoblastoma', 'CHI3L1-induced-Heredodegenerative Disorders, Nervous System', 'Death-associated-CST3', 'CST3-associated-Death', 'CST3-warrant-Death', 'GCK-associated-Coronary Artery Disease', 'Coronary Artery Disease-associated-GCK', 'TERC-identified-rs2293607', 'CCDC26-associated-Metabolic Syndrome', 'Metabolic Syndrome-associated-CCDC26', 'Glioblastoma-enhance-NFE2L2', 'H19-associated-Non-alcoholic Fatty Liver Disease', 'Non-alcoholic Fatty Liver Disease-associated-H19', 'SOD2-implicated-Hearing Loss', 'CDKN2B-AS1-promote-Heart Arrest', 'MIR200C-identify-Breast Neoplasms', 'MIR155-described-Communicable Diseases', 'PTCSC3-upregulated-Osteoporosis', 'MIR155-elevated-Critical Illness', 'PTCSC3-serve-Osteoporosis', 'Glucose-treat-Capsaicin', 'H19-found-Arthritis, Rheumatoid', 'MIR146A-develop-Neurodegenerative Diseases', 'Atherosclerosis-assessed-Glucose', 'Atherosclerosis-assessed-Cholesterol', 'Heparitin Sulfate-contain-Glycosylphosphatidylinositols', 'Glucose-elevate-Triglycerides', 'Ghrelin-reflect-Glucose', 'Hodgkin Disease-treated-Etoposide', 'Hodgkin Disease-contain-Etoposide', 'Lymphoma, B-Cell-treated-Daunorubicin', 'Lymphoma, B-Cell-treated-Rituximab', 'Rituximab-combined-Doxorubicin', 'Doxorubicin-include-Trastuzumab', 'Cardiotoxicity-associated-Doxorubicin', 'Doxorubicin-associated-Cardiotoxicity', 'Cardiotoxicity-include-Trastuzumab', 'Doxorubicin-accepted-Lymphoma, B-Cell', 'Rituximab-accepted-Lymphoma, B-Cell', 'Arthritis, Rheumatoid-compare-Gentamicins', 'Lincomycin-disappear-Epilepsy', 'Canagliflozin-tolerated-Diabetes Mellitus', 'Sarcoma-receive-Anthracyclines', 'Alzheimer Disease-underutilize-Glucose', 'Starch-lead-Dysbiosis', 'Pigmentation Disorders-modify-Ascorbic Acid', 'Cataract-glycated-Ascorbic Acid', 'Ascorbic Acid-increased-Cataract', 'Cataract-test-Ascorbic Acid', 'Glucose-play-Diabetes Mellitus', 'Anthracyclines-show-Small Cell Lung Carcinoma', 'Heart Failure-affect-Heparin', 'Hemangiosarcoma-consist-Anthracyclines', 'Gentamicins-administered-Streptococcal Infections', 'Glycerol-improve-Glomerulonephritis', 'Diabetes Mellitus-ascertained-Glucose', 'Hyaluronic Acid-incorporated-Arthritis', 'Glucose-considered-Dementia', 'Breast Neoplasms-require-Anthracyclines', 'Lactose-affect-Fractures, Bone', 'Heparin, Low-Molecular-Weight-improve-Infarction, Anterior Cerebral Artery', 'Diabetes Mellitus-fast-Glucose', 'Acarbose-improve-Diabetes Mellitus', 'Glucose-selected-Polycystic Ovary Syndrome', 'Hyaluronic Acid-present-Edema', 'Heparin, Low-Molecular-Weight-become-Venous Thromboembolism', 'Ascorbic Acid-decrease-Hyperpigmentation', 'Hemorrhage-use-Heparin, Low-Molecular-Weight', 'Anthracyclines-reduce-Drug-Related Side Effects and Adverse Reactions', 'Drug-Related Side Effects and Adverse Reactions-related-Anthracyclines', 'Diabetes Mellitus, Type 2-manage-Glucose', 'Diabetes Mellitus-diagnose-Glucose', 'Inositol-characterize-Alzheimer Disease', 'Glucose-compare-Mesial Movement of Teeth', 'Diabetes Mellitus-receive-Glucose', 'Glucose-determined-Congenital Hyperinsulinism', 'Ascorbic Acid-suggested-Pulmonary Disease, Chronic Obstructive', 'Ascorbic Acid-provide-Pulmonary Disease, Chronic Obstructive', 'Alzheimer Disease-compared-Lactose', 'Ascorbic Acid-related-Myocardial Infarction', 'Icodextrin-reduce-Heart Failure', 'Inositol-linked-Alzheimer Disease', 'Icodextrin-attenuate-Diabetes Mellitus', 'Genetic Diseases, Inborn-take-Glucose', 'Glyceraldehyde-induce-Death', 'Glucose-classify-Muscle Hypertonia', 'Venous Thrombosis-treated-Heparin', 'Mucopolysaccharidosis III-caused-Heparitin Sulfate', 'Hemorrhage-related-Heparin', 'Heart Failure-receive-Digoxin', 'Lip Diseases-Linked-Hyaluronic Acid', 'Glucose-include-Alzheimer Disease', 'Hearing Loss-associated-Ascorbic Acid', 'Ascorbic Acid-associated-Hearing Loss', 'Leukemia, Myeloid, Acute-contribute-Anthracyclines', 'Glucose-implicated-Alzheimer Disease', 'Glucose-assess-Glucose Metabolism Disorders', 'Glucose-used-Dehydration', 'Glucose-classify-Dehydration', 'Digoxin-treat-Heart Failure', 'Weight Gain-protect-Glucose', 'Glucose-calculate-Death', 'Diabetes Mellitus-determine-Glucose', 'Lysosomal Storage Diseases-result-Glycosaminoglycans', 'N-Acetylneuraminic Acid-investigate-Diabetes Mellitus', 'Glucose-compare-Hypotension', 'Neoplasms-assess-Doxorubicin', 'Idarubicin-associated-Drug-Related Side Effects and Adverse Reactions', 'Drug-Related Side Effects and Adverse Reactions-associated-Idarubicin', 'Ascorbic Acid-reduce-Muscular Diseases', 'Diabetes Mellitus-use-Streptozocin', 'Hyaluronic Acid-occur-Wounds and Injuries', 'Enoxaparin-require-Venous Thromboembolism', 'Galactose-given-Galactosemias', 'Glucose-associated-Post-Dural Puncture Headache', 'Post-Dural Puncture Headache-associated-Glucose', 'Glucose-affect-Fatigue', 'Glucose-inputt-Fatigue', 'Glucose-contribute-Diabetes Mellitus', 'Polysaccharides-mediate-Inflammation', 'Diabetes Mellitus, Type 2-undergo-Glucose', 'Glucose-categorized-Glucose Intolerance', 'Sepsis-receive-Amikacin', 'Doxorubicin-represent-Breast Neoplasms', 'Ascorbic Acid-assess-Pneumonia', 'Heart Failure-related-Doxorubicin', 'Glucose-measured-Alzheimer Disease', 'Heparin-used-Flushing', 'Ascorbic Acid-reduce-Cold Injury', 'Glucose-compare-Ketosis', 'Glucose-differ-Ketosis', 'Lymphoma, Non-Hodgkin-rely-Anthracyclines', 'Alzheimer Disease-increase-Ribose', 'Ascorbic Acid-prevent-Vision Disorders', 'Gallstones-give-Ascorbic Acid', 'Death-evaluated-Alginates', 'Lymphoma, B-Cell-diagnosed-Doxorubicin', 'Glucose-observed-Diabetes Mellitus', 'Aminoglycosides-reduce-Drug-Related Side Effects and Adverse Reactions', 'Urethral Neoplasms-change-Doxorubicin', 'Enoxaparin-treat-Venous Thromboembolism', 'Hyaluronic Acid-shown-Pain', 'Hyaluronic Acid-provide-Pain', 'Aminoglycosides-induced-Kidney Diseases', 'Enoxaparin-treated-Hemorrhage', 'Glucose-collected-Diabetes Mellitus', 'Heparin-associated-Bone Diseases, Metabolic', 'Bone Diseases, Metabolic-associated-Heparin', 'Glucose-exacerbate-Aneurysm', 'Glucose-complement-Diabetes Mellitus, Type 2', 'Glucose-associated-Tooth Diseases', 'Tooth Diseases-associated-Glucose', 'Neoplasms-assigned-Epirubicin', 'Breast Neoplasms-receive-Doxorubicin', 'Doxorubicin-combine-Breast Neoplasms', 'Doxorubicin-fit-Breast Neoplasms', 'Acute Kidney Injury-allocated-Heparin', 'Breast Neoplasms-progress-Anthracyclines', 'Kidney Diseases-receive-Aminoglycosides', 'Diabetes Mellitus, Type 2-improve-Canagliflozin', 'Weight Loss-impact-Glucose', 'Weight Loss-reduce-Glucose', 'Ouabain-induce-Death', 'Ascorbic Acid-prevent-Prostatic Neoplasms', 'Kidney Diseases-lead-Heparin', 'Diabetes Mellitus-define-Glucose', 'Glucose-used-Diabetes Mellitus', 'Glucose-manage-Diabetes Mellitus', 'Weight Loss-result-Polysaccharides', 'Ascorbic Acid-associated-Alzheimer Disease', 'Alzheimer Disease-associated-Ascorbic Acid', 'Hyaluronic Acid-reduce-Pain', 'Diabetes Mellitus-tend-Glucose', 'Heparin-involved-Neoplasms', 'Glucose-undergo-Diabetes Mellitus', 'Glucose-identify-Diabetes Mellitus', 'Drug-Related Side Effects and Adverse Reactions-treated-Aminoglycosides', 'Thioctic Acid-assess-rs63750424', 'Anthracyclines-remain-Leukemia, Myeloid, Acute', 'Heparin-use-Myocardial Infarction', 'Cholesterol-shown-Cardiovascular Diseases', 'Ceramides-associated-Diabetes Mellitus, Type 2', 'Diabetes Mellitus, Type 2-associated-Ceramides', 'gamma-Linolenic Acid-associated-Graft vs Host Disease', 'Graft vs Host Disease-associated-gamma-Linolenic Acid', 'Ergocalciferols-affect-Fractures, Bone', 'Cardiovascular Diseases-extend-Cholesterol', 'Cholesterol-calculate-Death', 'Atorvastatin-augment-Hyperemia', 'Cholecalciferol-associated-Death', 'Death-associated-Cholecalciferol', 'Cholecalciferol-prevent-Death', 'Fatty Acids, Omega-3-associated-Coronary Artery Disease', 'Coronary Artery Disease-associated-Fatty Acids, Omega-3', 'Fatty Acids, Omega-3-result-Atrial Fibrillation', 'Venlafaxine Hydrochloride-exhibit-Hyponatremia', 'Cholesterol-decrease-Aneurysm', 'Sodium Dodecyl Sulfate-associated-Psychomotor Disorders', 'Psychomotor Disorders-associated-Sodium Dodecyl Sulfate', 'Docosahexaenoic Acids-associated-Periodontal Diseases', 'Periodontal Diseases-associated-Docosahexaenoic Acids', 'Fatty Acids, Unsaturated-associated-Alzheimer Disease', 'Alzheimer Disease-associated-Fatty Acids, Unsaturated', 'Cholesterol-use-Metabolic Syndrome', 'Cholesterol-define-Metabolic Syndrome', 'Cholesterol-continue-Coronary Artery Disease', 'Oleic Acid-known-Death', 'Cholesterol-recommend-Coronary Artery Disease', 'Cholesterol-known-Coronary Artery Disease', 'Triglycerides-increase-Pain Insensitivity, Congenital', 'Obesity, Abdominal-examine-Fatty Acids, Nonesterified', 'Triglycerides-associated-Hypotension', 'Hypotension-associated-Triglycerides', 'Diabetes Mellitus-correlate-Cholesterol', 'Cholesterol-associated-Critical Illness', 'Critical Illness-associated-Cholesterol', 'Cholesterol-associated-Glucose Metabolism Disorders', 'Glucose Metabolism Disorders-associated-Cholesterol', 'Diabetes Mellitus-relate-Cholesterol', 'Calcitriol-measured-Heart Failure', 'Triglycerides-predict-Diabetes Mellitus', 'Latanoprost-reduce-Ocular Hypertension', 'Cholesterol-associate-Death', 'Death-associate-Cholesterol', 'Diabetes Mellitus, Type 2-assigned-Cholecalciferol', 'Fatty Acids, Unsaturated-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-Fatty Acids, Unsaturated', 'Triglycerides-associated-Cerebral Small Vessel Diseases', 'Cerebral Small Vessel Diseases-associated-Triglycerides', 'Fatty Acids, Omega-3-stimulate-Sarcopenia', 'Latanoprost-lower-Ocular Hypertension', 'Cholesterol-predict-Death', 'Epilepsy-treated-Valproic Acid', 'Cerebral Infarction-examined-Cholesterol', 'Hip Fractures-follow-Cholecalciferol', 'Metabolic Syndrome-use-Cholesterol', 'Ocular Hypertension-remain-Prostaglandins', 'Cholesterol-assess-Coronary Artery Disease', 'Dementia-follow-Cholesterol', 'Dementia-aged-Cholesterol', 'Coronary Artery Disease-associate-Cholesterol', 'Cholesterol-associate-Coronary Artery Disease', 'Coronary Artery Disease-randomized-Atorvastatin', 'Triglycerides-considered-Coronary Artery Disease', 'Asthma-associated-Leukotrienes', 'Leukotrienes-associated-Asthma', 'Fatty Acids, Unsaturated-play-Fractures, Bone', 'Cholesterol-show-Death', 'Hyponatremia-prescribe-Venlafaxine Hydrochloride', 'Cholesterol-considered-Cerebral Infarction', 'Atorvastatin-treat-Hematoma, Subdural, Chronic', 'Atherosclerosis-seem-Cholesterol', 'Phosphatidic Acids-counteract-Sarcopenia', 'Cholesterol-related-Death', 'Cholesterol-decrease-Death', 'Latanoprost-appear-Glaucoma', 'Valproic Acid-prolong-Seizures', 'Cholesterol-compared-Dementia', 'Fatty Acids, Unsaturated-supplemented-Osteoporosis', 'Lipofuscin-considered-Glycogen Storage Disease Type II', 'Tramadol-provide-Pain', 'Fatty Acids, Omega-3-associated-Death, Sudden', 'Death, Sudden-associated-Fatty Acids, Omega-3', 'Atrial Fibrillation-compare-Lipofuscin', 'Fatty Acids-associated-Neoplasms', 'Neoplasms-associated-Fatty Acids', 'Cholesterol-measured-Death', 'Fatty Acids, Unsaturated-involved-Inflammation', 'Tramadol-used-Pain', 'Tramadol-treat-Pain', 'Cholesterol-diagnosed-Diabetes Mellitus, Type 2', 'Coronary Artery Disease-provide-Fatty Acids', 'Valproic Acid-considered-Epilepsy', 'Prostaglandins-used-Glaucoma', 'Prostaglandins-treat-Glaucoma', 'Leukotrienes-compose-Asthma', 'Cholesterol-associated-Atrial Fibrillation', 'Atrial Fibrillation-associated-Cholesterol', 'Cholesterol-correlate-Seizures', 'Gaucher Disease-involved-Ceramides', 'Margarine-associated-Death', 'Death-associated-Margarine', 'gamma-Linolenic Acid-associated-Weight Gain', 'Weight Gain-associated-gamma-Linolenic Acid', 'Fatty Acids, Omega-3-associated-Cataract', 'Cataract-associated-Fatty Acids, Omega-3', 'Fatty Acids, Omega-3-protect-Dementia', 'Atorvastatin-use-Coronary Artery Disease', 'Atrial Fibrillation-derived-Lipofuscin', 'Epilepsy-receive-Valproic Acid', 'Cholesterol-prevent-Coronary Artery Disease', 'Cholesterol-appear-Death', 'Cholesterol-put-Heart Diseases', 'Cholesterol-correlate-Death', 'Acetates-related-Dementia', 'Hip Fractures-assigned-Cholecalciferol', 'Hip Fractures-receive-Cholecalciferol', 'Lisinopril-prescribed-Hypertension', 'Hypothyroidism-decrease-Thyrotropin', 'Glutathione-involved-Carcinogenesis', 'Glutathione-noted-Neurodegenerative Diseases', 'Octreotide-stop-Hemorrhage', 'Vancomycin-treated-Infections', 'Myocardial Infarction-undergo-Abciximab', 'Glutathione-associated-Alzheimer Disease', 'Alzheimer Disease-associated-Glutathione', 'Infections-result-Vancomycin', 'Aspartame-result-Insulin Resistance', 'Hypertension-treat-Enalapril', 'Ghrelin-lost-Metabolic Syndrome', 'Drug-Related Side Effects and Adverse Reactions-associated-Vancomycin', 'Vancomycin-associated-Drug-Related Side Effects and Adverse Reactions', 'Ghrelin-contribute-Metabolic Syndrome', 'Atazanavir Sulfate-approved-HIV Infections', 'Infections-followed-Vancomycin', 'Glutathione-measure-Anemia', 'Diarrhea-develop-Piperacillin, Tazobactam Drug Combination', 'Pain-compare-Lidocaine, Prilocaine Drug Combination', 'Omalizumab-improve-Asthma', 'Checkpoint Kinase 1-associated-Neoplasms', 'Neoplasms-associated-Checkpoint Kinase 1', 'Nivolumab-relapsed-Carcinoma, Non-Small-Cell Lung', 'Nivolumab-tolerate-Carcinoma, Non-Small-Cell Lung', 'Checkpoint Kinase 1-suggested-Carcinogenesis', 'Checkpoint Kinase 1-contain-Carcinogenesis', 'Neoplasms-receive-Checkpoint Kinase 1', 'Bevacizumab-receive-Drug-Related Side Effects and Adverse Reactions', 'Nivolumab-administered-Drug-Related Side Effects and Adverse Reactions', 'Alemtuzumab-associated-Death', 'Death-associated-Alemtuzumab', 'Bevacizumab-combined-Colorectal Neoplasms', 'Cardiomyopathy, Hypertrophic-encode-Infliximab', 'Infliximab-lead-Neurodegenerative Diseases', 'Alzheimer Disease-seen-Infliximab', 'Cetuximab-treated-Neoplasms', 'Carcinoma, Squamous Cell-treated-Cetuximab', 'Nivolumab-investigate-Squamous Cell Carcinoma of Head and Neck', 'Fractures, Bone-given-Denosumab', 'Arthritis, Rheumatoid-obtained-Alemtuzumab', 'Carcinoma, Squamous Cell-treat-Cetuximab', 'Rituximab-seem-Hemophilia A', 'Cardiomyopathies-explain-Infliximab', 'Trastuzumab-become-Breast Neoplasms', 'Denosumab-induce-Bisphosphonate-Associated Osteonecrosis of the Jaw', 'Ranibizumab-enable-Glycogen Storage Disease Type II', 'Lipopolysaccharides-induce-Inflammation', 'Trastuzumab-improve-Breast Neoplasms', 'Lipopolysaccharides-alter-Sepsis', 'rs11948613-associated-Alzheimer Disease', 'Alzheimer Disease-associated-rs11948613', 'rs1800562-associated-Hemochromatosis', 'Hemochromatosis-associated-rs1800562', 'rs5744455-related-Neoplasms', 'Lipopolysaccharides-relate-Heart Failure', 'Neurodegenerative Diseases-reflect-rs104893877', 'rs34637584-demonstrated-Parkinson Disease', 'rs1061170-related-Glycogen Storage Disease Type II', 'rs696217-associated-Metabolic Syndrome', 'Metabolic Syndrome-associated-rs696217', 'rs1801133-associated-Migraine with Aura', 'Migraine with Aura-associated-rs1801133', 'rs79658334-classified-Thyroid Neoplasms', 'rs58596362-result-Progeria', 'rs12252-associated-Infections', 'Infections-associated-rs12252', 'rs28365927-genotyped-Non-alcoholic Fatty Liver Disease', 'rs10824026-mediate-Atrial Fibrillation', 'rs28365927-confer-Non-alcoholic Fatty Liver Disease', 'Carcinogenesis-play-FASLG', 'Neoplasms-play-FASLG', 'FAS-play-Carcinogenesis', 'FAS-play-Neoplasms', 'rs17081935-associated-Atherosclerosis', 'Atherosclerosis-associated-rs17081935', 'ABCG2-recruited-Lung Neoplasms', 'ABCB1-recruited-Lung Neoplasms', 'TP53-aging-HNRNPC', 'FANCG-demonstrate-Osteogenesis Imperfecta', 'FANCG-demonstrate-Blast Injuries', 'Drug-Related Side Effects and Adverse Reactions-associated-CYP19A1', 'CYP19A1-associated-Drug-Related Side Effects and Adverse Reactions', 'APOE-point-Glaucoma', 'Thyrotropin-elevated-Death', 'Thyrotropin-contribute-Death', 'Thyrotropin-elevated-Hypothyroidism', 'Thyrotropin-contribute-Hypothyroidism', 'NR3C2-drive-Aneurysm', 'NR3C2-drive-Hypertension', 'Hematologic Diseases-demonstrate-Drug-Related Side Effects and Adverse Reactions', 'Hematologic Diseases-demonstrate-Etoposide', 'Cholecalciferol-reduce-Hip Fractures', 'Cholecalciferol-reduce-Fractures, Bone', 'ALB-associated-Osteoporosis', 'Osteoporosis-associated-ALB', 'ALB-associated-Inflammation', 'Inflammation-associated-ALB', 'CD34-co-express-PROM1', 'HECTD1-ubiquitinate-RUBCN', 'Glucosephosphate Dehydrogenase Deficiency-inhibit-Ventricular Remodeling', 'Fractures, Bone-increase-Death', 'Dementia-include-Chronic Disease', 'Brain Injuries, Traumatic-result-Death', 'Scrub Typhus-associated-Dementia', 'Dementia-associated-Scrub Typhus', 'Postpartum Hemorrhage-performed-Fractures, Bone', 'Drug-Related Side Effects and Adverse Reactions-associated-Breast Neoplasms', 'Breast Neoplasms-associated-Drug-Related Side Effects and Adverse Reactions', 'Obesity-increase-Hodgkin Disease', 'Sarcopenia-reduce-Death', 'Hemorrhage-categorized-Hematoma', 'Hemorrhage-categorized-Hematoma, Epidural, Spinal', 'Hemorrhage-categorized-Hematoma, Subdural', 'Hemorrhage-categorized-Subarachnoid Hemorrhage', 'Colorectal Neoplasms-develop-Anemia', 'Cerebral Intraventricular Hemorrhage-include-Hemorrhage', 'Subarachnoid Hemorrhage-include-Hemorrhage', 'Headache Disorders, Primary-separate-Headache', 'Hip Fractures-combined-Pelvic Neoplasms', 'Hemorrhage-account-Stroke', 'Skin Diseases-involve-Dermatitis, Atopic', 'Headache-include-Cough', 'Headache-precipitated-Cough', 'Skin Diseases-involve-Acne Vulgaris', 'Headache-include-Heart Diseases', 'Headache-brought-Heart Diseases', 'Skin Diseases-involve-Dermatitis, Contact', 'Skin Diseases-involve-Psoriasis', 'Skin Diseases-involve-Eczema', 'Inflammation-repair-Skin Diseases', 'Hyperuricemia-known-Cardiovascular Diseases', 'Accidental Injuries-minimize-Death', 'Seizures-concern-Sarcopenia', 'Seizures-discriminate-Sarcopenia', 'Muscle Weakness-defined-Adenomatous Polyposis Coli', 'Adenomatous Polyposis Coli-defined-Obesity', 'Muscle Weakness-apply-Sarcopenia', 'Spinal Cord Injuries-experience-Cardiovascular Diseases', 'Spinal Cord Injuries-experience-Diabetes Mellitus', 'Death-shown-Diabetes Mellitus', 'Dementia, Vascular-emerging-Neurodegenerative Diseases', 'Diabetes Mellitus-suffer-Death', 'Parkinson Disease-used-Osteoporosis', 'Diabetes Mellitus-include-Mastocytosis, Systemic', 'Obesity-include-Mastocytosis, Systemic', 'Hypertension-compare-Chronic Disease', 'Dementia-diagnosed-Fibrosis', 'Dementia-correlate-Brain Injuries', 'Dyspnea-admitted-Pleural Effusion', 'Bacteremia-include-Neoplasm Invasiveness', 'Sepsis-include-Neoplasm Invasiveness', 'Hydrocephalus-affect-Urinary Incontinence', 'Hypercholesterolemia-associated-Atherosclerosis', 'Atherosclerosis-associated-Hypercholesterolemia', 'Inflammation-correlate-Cardiovascular Diseases', 'Death-attributed-Hypertension', 'Inflammation-live-HIV Infections', 'Cardiovascular Diseases-live-HIV Infections', 'Alzheimer Disease-rank-Nervous System Diseases', 'Hearing Loss-include-Hearing Disorders', 'Obesity, Abdominal-shown-Death', 'Polyradiculoneuropathy, Chronic Inflammatory Demyelinating-measure-Hereditary Sensory and Motor Neuropathy', 'Obesity, Abdominal-associated-Death', 'Death-associated-Obesity, Abdominal', 'Digestive System Neoplasms-observed-Lung Neoplasms', 'Hepatitis C-increase-Osteoporosis', 'Delirium-occur-Hip Fractures', 'Hip Dislocation-associated-Pain', 'Pain-associated-Hip Dislocation', 'Delirium-related-Respiratory Insufficiency', 'Cardiac Output, Low-live-Dementia', 'Hemorrhage-reduce-Stroke', 'Infections-follow-Hip Fractures', 'Trichiasis-attributed-Trachoma', 'Dementia-identified-Death', 'Frailty-drawn-Myoclonic Epilepsies, Progressive', 'Sarcopenia-depend-Obesity', 'Chronic Disease-reduce-Atherosclerosis', 'Obesity-suffer-Sarcopenia', 'Malnutrition-suffer-Sarcopenia', 'Sarcopenia-associated-Malnutrition', 'Malnutrition-associated-Sarcopenia', 'Calculi-associated-Gingivitis', 'Gingivitis-associated-Calculi', 'Neurodegenerative Diseases-detect-Dementia', 'Neoplasms-diagnosed-Breast Neoplasms', 'Arthralgia-associated-Headache', 'Headache-associated-Arthralgia', 'Neck Pain-associated-Headache', 'Headache-associated-Neck Pain', 'Femoral Neck Fractures-result-Wounds and Injuries', 'Psoriasis-evaluated-Infections', 'Obesity, Abdominal-regarded-Obesity', 'Non-alcoholic Fatty Liver Disease-become-Liver Diseases', 'Obesity-associated-Muscle Weakness', 'Muscle Weakness-associated-Obesity', 'Muscular Diseases-associated-Sarcopenia', 'Sarcopenia-associated-Muscular Diseases', 'Neurologic Manifestations-induced-Sepsis', 'Pain-associated-Cardiac Output, Low', 'Cardiac Output, Low-associated-Pain', 'HIV Infections-shift-Acquired Immunodeficiency Syndrome', 'HIV Infections-shift-Chronic Disease', 'Bone Diseases-lead-Fractures, Bone', 'Ovarian Neoplasms-collected-Death', 'Inflammation-initiate-Cachexia', 'Inflammation-initiate-Fasciculation', 'Hallucinations-associated-Death', 'Death-associated-Hallucinations', 'Hallucinations-associated-Dementia', 'Dementia-associated-Hallucinations', 'Cardiac Output, Low-live-HIV Infections', 'Death-include-HIV Infections', 'Sarcopenia-associated-Bone Diseases, Metabolic', 'Bone Diseases, Metabolic-associated-Sarcopenia', 'Hallucinations-confounded-Dementia', 'Death-confounded-Dementia', 'Diabetes Mellitus, Type 2-include-Metabolic Diseases', 'Metabolic Diseases-rising-HIV Infections', 'Diabetes Mellitus, Type 2-rising-HIV Infections', 'Death-hospitalized-Myocardial Infarction', 'Thrombosis-initiated-Inflammation', 'Arbovirus Infections-include-HIV Infections', 'Carotid Artery Thrombosis-occur-Arterial Occlusive Diseases', 'Diabetes Mellitus, Type 2-associated-Neoplasms', 'Neoplasms-associated-Diabetes Mellitus, Type 2', 'Diabetes Mellitus, Type 2-diagnose-Neoplasms', 'Thyroid Diseases-related-Arrhythmias, Cardiac', 'Cerebral Infarction-linked-Neurodegenerative Diseases', 'Cerebral Infarction-linked-Alzheimer Disease', 'Death-considered-Kyphosis', 'Fractures, Bone-associated-Pneumonia', 'Pneumonia-associated-Fractures, Bone', "Sjogren's Syndrome-lead-Pain", "Sjogren's Syndrome-lead-Fatigue", "Sjogren's Syndrome-cause-Muscular Diseases", 'Pain-cause-Muscular Diseases', 'Dysbiosis-linked-Infections', 'Dysbiosis-linked-Diabetes Mellitus', 'Nerve Degeneration-manifest-Alzheimer Disease', 'Diabetes Mellitus-increase-Carcinoma, Hepatocellular', 'Diabetes Mellitus-increase-Hepatitis C, Chronic', 'Diabetes Mellitus-associated-Hepatitis C, Chronic', 'Hepatitis C, Chronic-associated-Diabetes Mellitus', 'Myotonic Dystrophy-associated-Hepatitis C, Chronic', 'Hepatitis C, Chronic-associated-Myotonic Dystrophy', 'Hematoma, Subdural, Chronic-caused-Rupture', 'Seizures-follow-Brain Injuries, Traumatic', 'Epilepsy-follow-Brain Injuries, Traumatic', 'Autoimmune Lymphoproliferative Syndrome-involved-Parkinson Disease', 'Autoimmune Lymphoproliferative Syndrome-involved-Sleep Wake Disorders', 'Cushing Syndrome-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-Cushing Syndrome', 'Parkinson Disease-exhibit-Autoimmune Lymphoproliferative Syndrome', 'Glaucoma-visit-Cataract', 'Fractures, Bone-undergo-Death', 'Low Back Pain-associated-Intervertebral Disc Degeneration', 'Intervertebral Disc Degeneration-associated-Low Back Pain', 'Cardiomyopathies-recognized-Heart Failure', 'Bradycardia-considered-Arrhythmias, Cardiac', 'Anomia-associated-Stroke', 'Stroke-associated-Anomia', 'Fatty Liver-associated-Death', 'Death-associated-Fatty Liver', 'Sarcopenia-investigate-Death', 'Sarcopenia-investigate-Kidney Failure, Chronic', 'Retinal Perforations-appear-Fatigue', 'Urinary Bladder Neoplasms-include-Neoplasms', 'Hyperpigmentation-appear-Fatigue', 'Coronavirus Infections-elicit-Infections', 'Neoplasms-include-Inflammatory Bowel Diseases', 'Inflammatory Bowel Diseases-associated-Neoplasms', 'Neoplasms-associated-Inflammatory Bowel Diseases', 'Inflammatory Bowel Diseases-associated-Breast Neoplasms, Male', 'Breast Neoplasms, Male-associated-Inflammatory Bowel Diseases', 'Glycogen Storage Disease Type II-present-Vision Disorders', 'Melanoma-constitute-Neoplasms', 'Osteoporosis-use-Fractures, Bone', 'Cardiac Output, Low-result-Brain Injuries, Traumatic', 'Dry Eye Syndromes-include-Headache Disorders, Secondary', 'Atrial Fibrillation-derived-Muscular Diseases', 'Ankle Fractures-manage-Chromosomal Instability', 'Lacrimal Apparatus Diseases-associated-Dacryocystitis', 'Dacryocystitis-associated-Lacrimal Apparatus Diseases', 'Charles Bonnet Syndrome-defined-Diabetes Mellitus', 'Osteoporosis-considered-Arthritis, Rheumatoid', 'Inflammation-assessed-Alzheimer Disease', 'Genetic Diseases, Inborn-cover-Neuromuscular Diseases', 'Restless Legs Syndrome-divided-Sleep Wake Disorders', 'Death-related-Hip Fractures', 'Tendinopathy-recognized-Fractures, Bone', 'Death-related-Fractures, Bone', 'Fractures, Bone-challenge-Osteoporotic Fractures', 'Fractures, Bone-increase-Osteoporosis', 'Fractures, Bone-operate-Death', 'Peripheral Arterial Disease-reflect-Pain', 'Adrenal Insufficiency-indicate-Edema', 'Vascular System Injuries-associate-Craniocerebral Trauma', 'Craniocerebral Trauma-associate-Vascular System Injuries', 'Vascular System Injuries-associate-Brachial Plexus Neuropathies', 'Brachial Plexus Neuropathies-associate-Vascular System Injuries', 'Skin Diseases-characterized-COL17A1', 'CRP-measured-Colorectal Neoplasms', 'ERBB2-observed-Breast Neoplasms', 'DAPK1-involved-Alzheimer Disease', 'Hepatitis C, Chronic-play-BGLAP', 'CLU-associated-Alzheimer Disease', 'Alzheimer Disease-associated-CLU', 'APOE-associated-Glaucoma', 'Glaucoma-associated-APOE', 'SLC5A2-show-Dementia', 'GPT-contribute-Death', 'SLC5A2-compare-Dementia', 'SLC5A2-associated-Dementia', 'Dementia-associated-SLC5A2', 'DYRK1A-investigate-Alzheimer Disease', 'DYRK1A-contribute-Alzheimer Disease', 'MAPT-associated-Retinal Degeneration', 'Retinal Degeneration-associated-MAPT', 'ADIPOQ-function-Death', 'EZH2-suppress-Aneurysm', 'CDKN2A-undergo-Breast Neoplasms', 'Anthocyanins-tolerate-Genetic Diseases, Inborn', 'MTNR1B-predict-Atherosclerosis', 'Vancomycin-code-Hip Fractures', 'Fatty Acids, Omega-3-result-Ataxia', 'Fatty Acids-involve-Parkinson Disease', 'Fatty Acids, Omega-3-affect-Sarcopenia', 'Drug-Related Side Effects and Adverse Reactions-associated-Lipofuscin', 'Lipofuscin-associated-Drug-Related Side Effects and Adverse Reactions', 'Angiotensin II-associated-Dementia', 'Dementia-associated-Angiotensin II', 'Inflammatory Bowel Diseases-treated-Crohn Disease', 'Cholecalciferol-prevent-Hip Fractures', 'TXNIP-exacerbate-Pancreatitis', 'TXNIP-induce-Heart Arrest', 'Glucose-considered-INS', 'Triglycerides-considered-INS', 'CRP-produced-Inflammation', 'CRP-produced-Brain Injuries, Traumatic', 'Vision Disorders-include-Sensation Disorders', 'Cholesterol-decrease-Triglycerides', 'Kidney Diseases-associate-Ventricular Remodeling', 'Ventricular Remodeling-associate-Kidney Diseases', 'Craniocerebral Trauma-lead-Hemorrhage', 'Craniocerebral Trauma-lead-Hematoma', 'Weight Loss-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-Weight Loss', 'Hypertension-associated-Neurodegenerative Diseases', 'Neurodegenerative Diseases-associated-Hypertension', 'Hypertension-show-Atrial Fibrillation', 'Hyperoxia-associated-Death', 'Death-associated-Hyperoxia', 'Hyperoxia-associated-Hypothermia', 'Hypothermia-associated-Hyperoxia', 'Hydrocephalus-result-Dementia', 'Hydrocephalus-result-Urinary Incontinence', 'Neoplasms-appear-Sarcopenia', 'Sarcopenia-occur-Neoplasms', 'Osteoporosis-pose-Death', 'Neurodegenerative Diseases-include-Chronic Disease', 'Endometrial Neoplasms-collected-Neoplasms', 'Renal Insufficiency-seen-Fractures, Bone', 'Hypertension-recognized-Dementia', 'Delirium-associated-Hearing Loss', 'Hearing Loss-associated-Delirium', 'Delirium-associated-Chronic Disease', 'Chronic Disease-associated-Delirium', 'Liver Cirrhosis-lead-Carcinoma, Hepatocellular', 'Liver Cirrhosis-lead-Fibrosis', 'Hemophilia A-initiate-Blood Coagulation Disorders, Inherited', 'Infertility, Female-postponed-Weight Loss', 'Infertility, Female-promote-Weight Loss', 'Obesity-promote-Weight Loss', 'Fractures, Bone-hospitalised-Death', 'Deglutition Disorders-characterized-Sleep Initiation and Maintenance Disorders', 'Ventricular Fibrillation-evaluate-Deglutition Disorders', 'Inflammatory Bowel Diseases-experience-Infections', 'Death-taken-Neoplasms', 'Neurodegenerative Diseases-underlie-Aneurysm', 'Diabetes Mellitus-cause-Hyperglycemia', 'Autoimmune Diseases-cause-Hyperglycemia', 'Seizures-fall-Cardiac Output, Low', 'Metabolic Diseases-increase-Death', 'Accidental Injuries-influenced-Sarcopenia', 'Abetalipoproteinemia-influenced-Sarcopenia', 'Sarcopenia-present-Muscular Diseases', 'Sarcopenia-present-Heart Failure', 'Dementia-underlie-Nervous System Diseases', 'Dementia-characterize-Nervous System Diseases', 'Aneurysm-known-Giant Cell Arteritis', 'Dementia-consist-Alzheimer Disease', 'HIV Infections-develop-Neoplasms', 'Hearing Loss-explained-Gait Disorders, Neurologic', 'Death-result-Respiratory Tract Diseases', 'Guillain-Barre Syndrome-diagnose-Infections', 'Periodontitis-associated-Tooth Loss', 'Tooth Loss-associated-Periodontitis', 'Psychomotor Agitation-receive-Cerebral Infarction', 'Sleep Initiation and Maintenance Disorders-receive-Cerebral Infarction', 'Erythema-consider-Psoriasis', 'Erythema-examine-Psoriasis', 'Alzheimer Disease-include-Erectile Dysfunction', 'Alzheimer Disease-include-Gait Disorders, Neurologic', 'Alzheimer Disease-include-Hearing Loss', 'Vision Disorders-use-Heterotaxy Syndrome', 'Alzheimer Disease-include-Taste Disorders', 'Pulmonary Arterial Hypertension-associated-Vascular Remodeling', 'Vascular Remodeling-associated-Pulmonary Arterial Hypertension', 'Epilepsies, Partial-recruited-Seizures', 'Fractures, Bone-seen-Osteoporosis', 'Fractures, Bone-seen-Wounds and Injuries', 'Pain-seen-Osteoporosis', 'Pain-seen-Wounds and Injuries', 'Osteoporosis-seen-Wounds and Injuries', 'Obesity, Abdominal-increase-Diabetes Mellitus', 'Glioblastoma-assigned-Neoplasms', 'Glioblastoma-present-Neoplasms', 'Myoclonus-followed-Death', 'Nervous System Diseases-experience-Tremor', 'Nervous System Diseases-experience-Gait Disorders, Neurologic', 'Nervous System Diseases-experience-Paralysis', 'Infections-remain-Hip Fractures', 'Colorectal Neoplasms-improve-Adenoma', 'Alzheimer Disease-begin-Tauopathies', 'Gout-develop-Dementia', 'Alzheimer Disease-begin-Neurodegenerative Diseases', 'Delirium-precipitated-Death', 'Alzheimer Disease-accumulating-Tauopathies', 'Glycogen Storage Disease Type II-characterised-Vision Disorders', 'Alzheimer Disease-accumulating-Neurodegenerative Diseases', 'Huntington Disease-cost-Parkinson Disease', 'Gait Disorders, Neurologic-indicate-Musculoskeletal Diseases', 'Muscle Weakness-augmented-Diabetes Mellitus', 'Diabetes Mellitus-show-Postoperative Complications', 'Myasthenia Gravis-cause-Muscle Weakness', 'Autoimmune Diseases-cause-Muscle Weakness', 'INS-found-Polycystic Ovary Syndrome', 'EREG-associated-Alzheimer Disease', 'Alzheimer Disease-associated-EREG', 'AMH-compare-HIV Infections', 'Pancreatitis-detect-TXNIP', 'BGLAP-associated-Polycystic Ovary Syndrome', 'Polycystic Ovary Syndrome-associated-BGLAP', 'MAPT-include-Alzheimer Disease', 'Diabetes Mellitus-affect-Glucose', 'Cholesterol-associated-Osteoporosis', 'Osteoporosis-associated-Cholesterol', 'Lysosomal-Associated Membrane Protein 2-involved-Pulmonary Disease, Chronic Obstructive', 'SF3B1-lead-EIF2AK1', 'SF3B1-lead-Protoporphyria, Erythropoietic', 'SOD1-indicate-GPX1', 'GPX1-investigated-Cataract', 'CAT-indicate-GPX1', 'SOD1-investigated-Cataract', 'CAT-investigated-Cataract', 'rs1800668-investigated-Cataract', 'GPX1-accelerate-Cataract', 'Inflammation-confer-Seizures', 'rs1001179-investigated-Cataract', 'CDKN1A-confer-Seizures', 'EGR1-confer-Seizures', 'CPT1A-silence-TP53', 'Fatty Acids-silence-CPT1A', 'ACAN-chosen-COL11A1', 'WNT3-associated-Sclerosis', 'Sclerosis-associated-WNT3', 'TNIP1-associated-Sclerosis', 'Sclerosis-associated-TNIP1', 'Dementia-associated-BIN1', 'BIN1-associated-Dementia', 'Dementia-associated-CR1', 'CR1-associated-Dementia', 'Dementia-associated-COX7C', 'COX7C-associated-Dementia', 'Dementia-associated-PICALM', 'PICALM-associated-Dementia', 'Neoplasms-obtained-ROS1', 'Neoplasms-obtained-ALK', 'PRKAA2-represent-Brain Injuries', 'PER2-activate-Hyperplasia', 'CYP1A1-mediated-NR1I2', 'Nervous System Diseases-associated-Disease', 'Disease-associated-Nervous System Diseases', 'TNF-associated-Nervous System Diseases', 'Nervous System Diseases-associated-TNF', 'HBEGF-associated-Nervous System Diseases', 'Nervous System Diseases-associated-HBEGF', 'Glioblastoma-evaluated-TARDBP', 'Coronary Artery Disease-associated-GDNF', 'GDNF-associated-Coronary Artery Disease', 'Drug-Related Side Effects and Adverse Reactions-attenuate-CYP1A1', 'ACOX1-dysregulated-Neoplasms', 'ACOX2-dysregulated-Neoplasms', 'ACOX3-dysregulated-Neoplasms', 'SIRT1-highlight-Inflammation', 'CRP-highlight-Inflammation', 'MTOR-upregulate-PRKN', 'ATG7-upregulate-PRKN', 'CD5L-related-Dementia', 'CD14-related-Dementia', 'Lipofuscin-upregulate-PRKN', 'NCAM1-related-Dementia', 'CD40LG-related-Dementia', 'BAX-cleave-PARP1', 'CD163-related-Dementia', 'CXCL16-related-Dementia', 'TP53-cleave-PARP1', 'CXCL12-related-Dementia', 'DPP4-related-Dementia', 'BAK1-cleave-PARP1', 'TP53-correlate-PARP1', 'BAX-correlate-PARP1', 'TP53-correlate-Neoplasms', 'PARP1-cleave-Neoplasms', 'BAX-correlate-Neoplasms', 'YAP1-contribute-PIEZO1', 'YAP1-target-PIEZO1', 'PIEZO1-delay-Cartilage Diseases', 'Breast Neoplasms-correlated-SIRT7', 'Breast Neoplasms-correlated-USP17L2', 'LMX1B-increase-Dinoprostone', 'LMX1B-suppress-Inflammation', 'Dinoprostone-include-Inflammation', 'CD47-contribute-CD24', 'CD24-compensate-Genetic Diseases, Inborn', 'Calcinosis-accompany-RUNX2', 'SIRT6-promote-Calcinosis', 'Calcinosis-induced-BMP2', 'Ovarian Diseases-base-MAPK1', 'Ovarian Diseases-established-MAPK1', 'Ovarian Diseases-base-AREG', 'Ovarian Diseases-established-AREG', 'CLU-prevent-Drug-Related Side Effects and Adverse Reactions', 'Ovarian Diseases-base-STK24', 'Ovarian Diseases-established-STK24', 'HERPUD1-prevent-Drug-Related Side Effects and Adverse Reactions', 'Ovarian Diseases-base-ANXA1', 'Ovarian Diseases-established-ANXA1', 'Ovarian Diseases-base-ATG7', 'Ovarian Diseases-established-ATG7', 'HMBS-synergize-CTNNB1', 'HMBS-lead-Neoplasms', 'NR4A1-identified-Sleep Wake Disorders', 'NR4A1-linked-Sleep Wake Disorders', 'IL1B-identified-Sleep Wake Disorders', 'IL1B-linked-Sleep Wake Disorders', 'SIRT6-enforce-Glycogen', 'Glycogen Storage Disease Type II-modulate-Inflammation', 'NR4A2-modulate-Inflammation', 'Pulmonary Disease, Chronic Obstructive-divided-CRP', 'Pulmonary Disease, Chronic Obstructive-collect-TNF', 'IGF1-affect-TXNIP', 'IGF1-affect-Glucose', 'Pain-assayed-CRP', 'S100A1-display-Alzheimer Disease', 'AIF1-display-Alzheimer Disease', 'TET2-yield-Leukemia, Myelomonocytic, Juvenile', 'LRG1-investigate-LEP', 'LRG1-include-LEP', 'LRG1-investigate-Obesity', 'SRSF2-yield-Leukemia, Myelomonocytic, Juvenile', 'LEP-include-Obesity', 'SRSF2-occur-TET2', 'Leukemia, Myelomonocytic, Chronic-occur-SRSF2', 'Leukemia, Myelomonocytic, Juvenile-occur-SRSF2', 'Leukemia, Myelomonocytic, Chronic-occur-TET2', 'Leukemia, Myelomonocytic, Juvenile-occur-TET2', 'MRPS26-linked-Carcinoma, Non-Small-Cell Lung', 'CHI3L1-increase-Disorders of Sex Development', 'CHI3L1-promote-BMP2', 'BMP2-induce-Disorders of Sex Development', 'CHI3L1-induce-Disorders of Sex Development', 'CRP-associated-Pain', 'Pain-associated-CRP', 'BRCA1-carry-Breast Neoplasms', 'BRCA2-carry-Breast Neoplasms', 'Heart Failure-couple-AKT1', 'IGF1R-couple-Heart Failure', 'IGF1R-overexpressed-Heart Failure', 'Heart Failure-couple-PTK2B', 'Heart Failure-overexpressed-PTK2B', 'Heart Failure-couple-ULK1', 'Heart Failure-overexpressed-ULK1', 'NOS3-increased-NOX1', 'NOX1-increased-Alzheimer Disease', 'NOS3-increased-Alzheimer Disease', 'POU5F1-observed-Multiple Chronic Conditions', 'FASLG-related-Neoplasms', 'FASLG-related-Hyperplasia', 'BCL2-related-Neoplasms', 'BCL2-related-Hyperplasia', 'BAX-related-Neoplasms', 'BAX-related-Hyperplasia', 'Alzheimer Disease-decrease-TP53', 'CXCL8-arrested-Alzheimer Disease', 'Alzheimer Disease-increase-CDKN2A', 'IL1B-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-IL1B', 'TNF-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-TNF', 'FPR2-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-FPR2', 'VEGFA-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-VEGFA', 'ITGAX-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-ITGAX', 'CXCL1-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-CXCL1', 'PTGS2-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-PTGS2', 'CYBB-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-CYBB', 'CEACAM8-increase-SELL', 'CCR5-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-CCR5', 'CEACAM8-decrease-FCGR3A', 'CEACAM8-increase-CXCR4', 'CEACAM8-decrease-ICAM1', 'Butyrates-increase-Propionates', 'Butyrates-decrease-CEACAM8', 'CEACAM8-increase-Propionates', 'Butyrates-increase-SELL', 'SELL-increase-Propionates', 'Butyrates-decrease-FCGR3A', 'FCGR3A-increase-Propionates', 'Butyrates-increase-CXCR4', 'Propionates-increase-CXCR4', 'Butyrates-decrease-ICAM1', 'Propionates-increase-ICAM1', 'Alzheimer Disease-involved-HDAC1', 'Alzheimer Disease-involved-HDAC2', 'TP53-limited-Neoplasms', 'Alzheimer Disease-aggravate-Neurogenic Inflammation', 'Alzheimer Disease-aggravate-Mitochondrial Diseases', 'CWC27-lead-Alzheimer Disease', 'CWC27-aggravate-Neurogenic Inflammation', 'TULP4-lead-Alzheimer Disease', 'TULP4-aggravate-Neurogenic Inflammation', 'SHOX2-hinder-CACNA1G', 'SHOX2-find-Neurologic Manifestations', 'PTK2-lead-Alzheimer Disease', 'GLS-accompanied-SLC14A1', 'KLRC2-associated-Coronary Artery Disease', 'Coronary Artery Disease-associated-KLRC2', 'KLRC2-associated-HIV Infections', 'HIV Infections-associated-KLRC2', 'B3GAT1-associated-Coronary Artery Disease', 'Coronary Artery Disease-associated-B3GAT1', 'GLS-induce-Mitochondrial Diseases', 'B3GAT1-associated-HIV Infections', 'HIV Infections-associated-B3GAT1', 'HDAC9-lead-Alzheimer Disease', 'CAMP-associated-Lung Diseases', 'Lung Diseases-associated-CAMP', 'HDAC9-aggravate-Neurogenic Inflammation', 'MSTN-lead-Muscular Atrophy', 'Adrenal Insufficiency-inhibit-SHOX2', 'MSTN-lead-Fibrosis', 'STMN1-associated-Lung Diseases', 'Lung Diseases-associated-STMN1', 'HOMER1-lead-Alzheimer Disease', 'HOMER1-aggravate-Neurogenic Inflammation', 'SCGB1D4-increase-Hypoxia', 'Hypoxia-associated-SCGB1D4', 'SCGB1D4-associated-Hypoxia', 'Hypoxia-associated-MTOR', 'MTOR-associated-Hypoxia', 'Infliximab-affect-ORAI1', 'Infliximab-affect-TRPM2', 'VEGFA-involved-Brain Diseases', 'PGF-involved-Brain Diseases', 'CCL11-involved-Brain Diseases', 'Polycystic Kidney, Autosomal Dominant-increase-PKD2', 'CGAS-target-Neoplasms', 'Hyperalgesia-associated-NGF', 'NGF-associated-Hyperalgesia', 'Hyperalgesia-reduce-NGF', 'Hyperalgesia-associated-CALCA', 'CALCA-associated-Hyperalgesia', 'CGAS-activate-Death', 'Hyperalgesia-associated-NTRK1', 'NTRK1-associated-Hyperalgesia', 'TNFRSF11B-maintain-Osteoporotic Fractures', 'TNFSF11-maintain-Osteoporotic Fractures', 'Neoplasms-induced-KL', 'Muscular Atrophy-lead-FBXO32', 'Inflammation-promote-NFE2L2', 'Inflammation-promote-SIRT1', 'KL-indicate-Colorectal Neoplasms', 'ADGRA2-promote-Osteoporosis', 'CD27-associated-Death', 'Death-associated-CD27', 'CD28-associated-Death', 'Death-associated-CD28', 'Mitochondrial Diseases-restore-NFE2L2', 'Microcephaly-arise-ERCC8', 'Microcephaly-arise-ERCC6', 'RUNX1-mutated-Leukemia, Myeloid, Acute', 'CEBPA-mutated-Leukemia, Myeloid, Acute', 'VDR-influence-Sarcopenia', 'Cardiotoxicity-lead-Death', 'Glucose-measured-Dyspnea', 'Doxorubicin-lead-Death', 'Glycerol-measured-Dyspnea', 'Fatty Acids-measured-Dyspnea', 'Anthracyclines-lead-Death', 'rs199473071-subjected-Doxorubicin', 'rs199473071-treated-Doxorubicin', 'rs199473071-exhibit-Hypertrophy', 'Sphingolipids-promote-Ceramides', 'Sphingolipids-promote-Adenocarcinoma of Lung', 'Oxylipins-derived-Fatty Acids, Unsaturated', 'Oxylipins-involved-Inflammation', 'Fatty Acids, Volatile-reported-Vaginosis, Bacterial', 'Acetates-reported-Vaginosis, Bacterial', 'Butyrates-reported-Vaginosis, Bacterial', 'Propionates-reported-Vaginosis, Bacterial', 'Hypotension-decrease-Cholesterol', 'Hypotension-decrease-Triglycerides', 'Lysophosphatidylcholines-differ-HIV Infections', 'Ceramides-differ-HIV Infections', 'rs534125149-identify-rs201988637', 'rs534125149-identify-MFGE8', 'rs534125149-identify-Coronary Artery Disease', 'Werner Syndrome-diagnosed-rs1389340786', 'NAGLU-prevent-Neurodegenerative Diseases', 'NAGLU-prevent-Alzheimer Disease', 'Death-mediated-ANGPT2', 'INSL3-associated-Hypertension', 'Hypertension-associated-INSL3', 'INSL3-reflect-Hypertension', 'INSL3-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-INSL3', 'INSL3-reflect-Cardiovascular Diseases', 'INSL3-associated-Neoplasms', 'Neoplasms-associated-INSL3', 'INSL3-reflect-Neoplasms', 'INSL3-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-INSL3', 'rs57629361-altered-rs267607547', 'INSL3-associate-Hypertension', 'Hypertension-associate-INSL3', 'Progeria-farnesylate-Polyendocrinopathies, Autoimmune', 'INSL3-associate-Cardiovascular Diseases', 'Cardiovascular Diseases-associate-INSL3', 'Neurodegenerative Diseases-used-Glucose Metabolism Disorders', 'Neurodegenerative Diseases-evaluate-Glucose Metabolism Disorders', 'Neurodegenerative Diseases-indicate-Nerve Degeneration', 'Glucose Metabolism Disorders-indicate-Nerve Degeneration', 'Chronobiology Disorders-develop-Pulmonary Disease, Chronic Obstructive', 'ARNTL-develop-Pulmonary Disease, Chronic Obstructive', 'Progeria-altered-rs57629361', 'Polyendocrinopathies, Autoimmune-altered-rs57629361', 'Polyendocrinopathies, Autoimmune-farnesylate-rs267607547', 'Death-decrease-Alzheimer Disease', 'MAPT-decrease-Death', 'INS-tested-Alzheimer Disease', 'MAPT-find-Alzheimer Disease', 'MAPT-find-Congenital, Hereditary, and Neonatal Diseases and Abnormalities', 'Hypoxia-suppress-Metabolic Diseases', 'Glucose-stimulate-Hypoxia', 'Glucose-suppress-Metabolic Diseases', 'MAPT-associated-Neurodegenerative Diseases', 'Neurodegenerative Diseases-associated-MAPT', 'INS-lead-Hyperglycemia', 'Hypoproteinemia-reveal-Neoplasms', 'SIRT6-attenuate-Calcinosis', 'Cystadenocarcinoma, Serous-reveal-Neoplasms', 'Hypoalbuminemia-associated-ALB', 'ALB-associated-Hypoalbuminemia', 'Neoplasms-reveal-Respiratory Insufficiency', 'Prostaglandins E-associated-Death', 'Death-associated-Prostaglandins E', 'Prostaglandins E-associated-Communicable Diseases', 'Communicable Diseases-associated-Prostaglandins E', 'Parkinson Disease-characterized-Nerve Degeneration', 'Inflammation-involve-NLRP3', 'SIRT1-used-Huntington Disease', 'SIRT1-used-Psoriasis', 'Glycogen Storage Disease Type II-characterized-Muscular Disorders, Atrophic', 'BDNF-associated-Dementia', 'Dementia-associated-BDNF', 'Inflammation-examined-Chronic Kidney Disease-Mineral and Bone Disorder', 'Inflammation-induced-Obesity', 'NFE2L2-triggered-Inflammation', 'NFE2L2-examined-Chronic Kidney Disease-Mineral and Bone Disorder', 'Muscular Atrophy-include-Fasciculation', 'Sarcopenia-include-Fasciculation', 'Fasciculation-include-Chronic Kidney Disease-Mineral and Bone Disorder', 'Fasciculation-associated-Chronic Kidney Disease-Mineral and Bone Disorder', 'Chronic Kidney Disease-Mineral and Bone Disorder-associated-Fasciculation', 'Muscular Atrophy-associated-Chronic Kidney Disease-Mineral and Bone Disorder', 'Chronic Kidney Disease-Mineral and Bone Disorder-associated-Muscular Atrophy', 'Sarcopenia-associated-Chronic Kidney Disease-Mineral and Bone Disorder', 'Chronic Kidney Disease-Mineral and Bone Disorder-associated-Sarcopenia', 'NFE2L2-involved-Chronic Kidney Disease-Mineral and Bone Disorder', 'Cholesterol-reveal-Dementia', 'IGF1-associated-Oculocerebrorenal Syndrome', 'Oculocerebrorenal Syndrome-associated-IGF1', 'IGF1-associated-Metabolic Diseases', 'Metabolic Diseases-associated-IGF1', 'FOXO1-play-Neoplasms', 'Deglutition Disorders-cause-Malabsorption Syndromes', 'Chronic Disease-increase-Inflammation', 'Sarcopenia-increase-Inflammation', 'Dementia-cause-Malabsorption Syndromes', 'Anorexia-cause-Malabsorption Syndromes', 'Fatigue-cause-Malabsorption Syndromes', 'Malabsorption Syndromes-cause-Malnutrition', 'Malabsorption Syndromes-cause-Hypoalbuminemia', 'Malabsorption Syndromes-cause-Anemia', 'Amyotrophic Lateral Sclerosis-include-Neurodegenerative Diseases', 'Stroke-include-Neurodegenerative Diseases', 'Malabsorption Syndromes-cause-CRP', 'Multiple Sclerosis-include-Neurodegenerative Diseases', 'Bacterial Infections-observed-Atherosclerosis', 'CHI3L1-show-Alzheimer Disease', 'NEFL-classify-Alzheimer Disease', 'NEFL-classify-Frontotemporal Lobar Degeneration', 'NFE2L2-involved-Neurodegenerative Diseases', 'NFE2L2-involved-Alzheimer Disease', 'Anthocyanins-retain-Vision Disorders', 'NFE2L2-involved-Parkinson Disease', 'NFE2L2-involved-Huntington Disease', 'NFE2L2-involved-Amyotrophic Lateral Sclerosis', 'NFE2L2-involved-Stroke', 'Anthocyanins-reduce-Glaucoma', 'NFE2L2-involved-Multiple Sclerosis', 'Anthocyanins-decrease-Dry Eye Syndromes', 'Anthocyanins-decrease-Cataract', 'Sialic Acid Storage Disease-associated-Myoclonic Epilepsies, Progressive', 'Myoclonic Epilepsies, Progressive-associated-Sialic Acid Storage Disease', 'Nerve Degeneration-mediate-Leukoencephalopathies', 'Nerve Degeneration-account-Atrophy', 'Sialic Acid Storage Disease-associated-Charles Bonnet Syndrome', 'Charles Bonnet Syndrome-associated-Sialic Acid Storage Disease', 'Leukoencephalopathies-account-Atrophy', 'Nerve Degeneration-mediate-MAPT', 'CST3-associated-Sialic Acid Storage Disease', 'Sialic Acid Storage Disease-associated-CST3', 'MAPT-account-Atrophy', 'CST3-associated-Myoclonic Epilepsies, Progressive', 'Myoclonic Epilepsies, Progressive-associated-CST3', 'CST3-associated-Charles Bonnet Syndrome', 'Charles Bonnet Syndrome-associated-CST3', 'Polycystic Ovary Syndrome-characterized-Obesity', 'Polycystic Ovary Syndrome-characterized-Hyperglycemia', 'Polycystic Ovary Syndrome-develop-Dyslipidemias', 'Polycystic Ovary Syndrome-characterized-Dyslipidemias', 'Polycystic Ovary Syndrome-develop-INS', 'Polycystic Ovary Syndrome-characterized-Proteinuria', 'Weight Loss-prevent-Metabolic Diseases', 'INS-improved-Weight Loss', 'Death-prevent-Parkinson Disease', 'NFE2L2-prevent-Parkinson Disease', 'Muscular Atrophy, Spinal-caused-SMN1', 'Neuromuscular Diseases-caused-SMN1', 'Amyloidosis-induce-Neurodegenerative Diseases', 'Amyloidosis-promote-MAPT', 'MAPT-induce-Neurodegenerative Diseases', 'MSTN-mediated-Hypoadrenocorticism, Familial', 'CRP-associated-Renal Insufficiency', 'Renal Insufficiency-associated-CRP', 'Glucose-reduce-Dementia', 'Sleep Initiation and Maintenance Disorders-regulated-Fatty Acids', 'Aneurysm-occur-Tauopathies', 'rs63751438-occur-Aneurysm', 'rs63751438-occur-Tauopathies', 'Dementia-increase-PDE11A', 'Neoplasms-investigate-Colorectal Neoplasms', 'KL-investigate-Colorectal Neoplasms', 'Osteoarthritis-associated-Mitochondrial Diseases', 'Mitochondrial Diseases-associated-Osteoarthritis', 'LONP1-accelerate-Osteoarthritis', 'LONP1-accelerate-Mitochondrial Diseases', 'Huntington Disease-associated-HTT', 'HTT-associated-Huntington Disease', 'Cholesterol-disrupted-Inflammation', 'KL-used-Colorectal Neoplasms', 'Cholesterol-disrupted-Metabolic Diseases', 'Neurodegenerative Diseases-associated-HTT', 'HTT-associated-Neurodegenerative Diseases', 'Fibrosis-occur-Cardiovascular Diseases', 'Hypertrophy-occur-Cardiovascular Diseases', 'Glucose-induce-Coronary Artery Disease', 'Cerebral Infarction-reduce-Wounds and Injuries', 'Cerebral Infarction-rescue-SIRT3', 'SIRT3-reduce-Wounds and Injuries', 'Inflammation-drive-End Stage Liver Disease', 'CD38-mitigate-Inflammation', 'Hesperidin-ameliorate-Mitochondrial Diseases', 'Hesperidin-ameliorate-Heart Arrest', 'Cardiovascular Diseases-identify-Death', 'Obesity-determine-Immunologic Deficiency Syndromes', 'Neoplasms-include-Communicable Diseases', 'Heart Failure-include-Communicable Diseases', 'Diabetes Mellitus-include-Communicable Diseases', 'Obesity-determine-INS', 'Obesity-include-Communicable Diseases', 'Atrial Fibrillation-suggested-Obesity', 'LRG1-implicated-Communicable Diseases', 'Atrial Fibrillation-suggested-Diabetes Mellitus', 'LRG1-implicated-Neoplasms', 'LRG1-implicated-Heart Failure', 'Atrial Fibrillation-shift-Heart Failure', 'LRG1-implicated-Diabetes Mellitus', 'Atrial Fibrillation-shift-Hypertension', 'LRG1-implicated-Obesity', 'Atrial Fibrillation-shift-Fatty Acids', 'Cholesterol-tend-Heart Diseases', 'Cholesterol-tend-Diabetes Mellitus', 'Cholesterol-tend-Respiratory Tract Diseases', 'Chronic Traumatic Encephalopathy-associated-Craniocerebral Trauma', 'Craniocerebral Trauma-associated-Chronic Traumatic Encephalopathy', 'Neurodegenerative Diseases-associated-Craniocerebral Trauma', 'Craniocerebral Trauma-associated-Neurodegenerative Diseases', 'Chronic Traumatic Encephalopathy-characterised-MAPT', 'Neurodegenerative Diseases-characterised-MAPT', 'Craniocerebral Trauma-characterised-MAPT', 'Lung Injury-associated-Fibrosis', 'Fibrosis-associated-Lung Injury', 'UCP2-support-Fibrosis', 'CD200-alter-Critical Illness', 'Ventricular Remodeling-collect-Hypertension', 'Fatty Acids-aggravate-Alzheimer Disease', 'Infections-generate-Calcitriol', 'Sepsis-generate-Calcitriol', 'Hyperinsulinism-seen-Obesity', 'Respiratory Tract Infections-generate-Calcitriol', 'Hyperinsulinism-seen-Metabolic Syndrome', 'Hyperinsulinism-studied-Doxorubicin', 'Leukemia, Myeloid, Acute-eradicate-Leukemia', 'Sarcopenia-include-Inflammation', 'Sarcopenia-share-Inflammation', 'Symptom Flare Up-worsen-Diabetes Mellitus', 'Sarcopenia-include-Hyperammonemia', 'Sarcopenia-share-Hyperammonemia', 'Inflammation-include-Fibrosis', 'Symptom Flare Up-worsen-Alzheimer Disease', 'Hyperammonemia-include-Fibrosis', 'Sarcopenia-include-INS', 'Sarcopenia-share-INS', 'INS-include-Fibrosis', 'Diabetes Mellitus-worsen-Alzheimer Disease', 'LEP-worsen-Symptom Flare Up', 'LEP-worsen-Diabetes Mellitus', 'Coronary Artery Disease-increase-Glucose', 'Glucose-associated-Hypertension', 'Hypertension-associated-Glucose', 'GPT-reflect-Sarcopenia', 'GPT-reflect-Malnutrition', 'GPT-reflect-Cardiovascular Diseases', 'Tramadol-indicated-Pain', 'Tramadol-indicated-Cough', 'Sotos Syndrome-predispose-Glucose', 'Neurodegenerative Diseases-lower-Dementia', 'Glucose-resemble-Diabetes Mellitus', 'Neurodegenerative Diseases-impact-Cholesterol', 'Dementia-impact-Cholesterol', 'Cholesterol-impact-Alzheimer Disease', 'Muscular Diseases-enhance-Muscular Dystrophy, Duchenne', 'METRNL-enhance-Muscular Dystrophy, Duchenne', 'Obesity-play-Metabolic Syndrome', 'METRNL-activate-Inflammation', 'METRNL-activate-Fasciculation', 'Diabetes Mellitus-play-Metabolic Syndrome', 'Weight Loss-play-Metabolic Syndrome', 'Heart Diseases-play-Metabolic Syndrome', 'Obesity-involved-METRNL', 'Diabetes Mellitus-involved-METRNL', 'Weight Loss-involved-METRNL', 'Heart Diseases-involved-METRNL', 'METRNL-play-Metabolic Syndrome', 'METRNL-regarded-Inflammation', 'Werner Syndrome-caused-WRN', 'Aging, Premature-caused-WRN', 'Lipodystrophy-diagnose-Werner Syndrome', 'Osteoarthritis-played-TRIB3', 'TRIB3-played-Inflammation', 'Adrenal Insufficiency-predict-Cardiovascular Diseases', 'Aortic Diseases-influence-MAPT', 'Adrenal Insufficiency-predict-Death', 'Adrenal Insufficiency-uncarboxylated-MGP', 'Neoplasms-delay-Hypotension', 'MGP-predict-Cardiovascular Diseases', 'Neoplasms-delay-Inflammation', 'MGP-predict-Death', 'Neoplasms-delay-INS', 'Cerebral Amyloid Angiopathy-accelerate-MAPT', 'Cerebral Amyloid Angiopathy-promote-MAPT', 'SREBF1-diagnose-Sarcopenia', 'TARDBP-associated-Dementia', 'Dementia-associated-TARDBP', 'Osteosarcoma-worsen-Calcinosis', 'SIRT7-activate-Glucose', 'SIRT7-activate-Osteosarcoma', 'SIRT7-worsen-Calcinosis', 'Calcinosis-activate-Glucose', 'Genetic Diseases, Inborn-caused-TP63', 'Alzheimer Disease-correlate-MAPT', 'Breast Neoplasms-occur-TP53', 'Precursor Cell Lymphoblastic Leukemia-Lymphoma-associated-Eosinophilia', 'Eosinophilia-associated-Precursor Cell Lymphoblastic Leukemia-Lymphoma', 'PDGFRB-associated-Aneurysm', 'Aneurysm-associated-PDGFRB', 'PDGFRB-associated-Precursor Cell Lymphoblastic Leukemia-Lymphoma', 'Precursor Cell Lymphoblastic Leukemia-Lymphoma-associated-PDGFRB', 'Muscular Dystrophy, Duchenne-caused-DMD', 'PDGFRB-associated-Eosinophilia', 'Eosinophilia-associated-PDGFRB', 'Neuromuscular Diseases-caused-DMD', 'LEP-affect-Obesity', 'LEP-play-Asthma', 'LEP-play-Pulmonary Disease, Chronic Obstructive', 'SIRT1-involved-Heart Failure', 'SIRT1-play-Death', 'CRP-assessed-Heart Diseases', 'CRP-assessed-Stroke', 'Neoplasms-described-Lung Neoplasms', 'Neoplasms-deleted-Lung Neoplasms', 'Hypotension-associated-Back Pain', 'Back Pain-associated-Hypotension', 'Cardiotoxicity-known-Hypoxia', 'Tauopathies-include-Alzheimer Disease', 'Cardiotoxicity-stimulate-Ischemia', 'Supranuclear Palsy, Progressive-include-Alzheimer Disease', 'Triglycerides-associated-Back Pain', 'Back Pain-associated-Triglycerides', 'TUSC2-deleted-Lung Neoplasms', 'Hypoxia-stimulate-Ischemia', 'Doxorubicin-cause-Cardiotoxicity', 'Doxorubicin-stimulate-Ischemia', 'Sleep Wake Disorders-associated-CRP', 'CRP-associated-Sleep Wake Disorders', 'FNDC5-stabilize-SIRT6', 'SLC29A1-correlate-UCP1', 'CTNNB1-inhibit-CCL19', 'MAPK14-suppressed-NR3C1', 'TERT-increase-SIRT1', 'TBK1-engage-MYD88', 'IRF3-engage-MYD88', 'STAT1-engage-MYD88', 'TUG1-decrease-VEGFA', 'CD14-find-MPO', 'CD14-find-CD40LG', 'SIRT6-suppress-CHMP2B', 'NTRK2-elevate-BCL2L2', 'NTRK2-activate-MAPK7', 'BDNF-elevate-BCL2L2', 'MAPK7-elevate-BCL2L2', 'BDNF-activate-MAPK7', 'TEAD1-increase-ACAN', 'YAP1-increase-ACAN', 'PRKAA1-evoke-NFE2L2', 'PRKAA1-evoke-ARNTL', 'USP17L2-regulate-SIRT7', 'SIRT6-enhance-LMNA', 'NLRP3-silence-LMX1B', 'CD40LG-delivered-CXCL12', 'CD47-augmented-QPCT', 'CD4-upregulate-CTLA4', 'CD8A-upregulate-CTLA4', 'JAK2-stimulated-GH1', 'LRG1-correlated-LEP', 'LRG1-correlated-CRP', 'LRG1-correlated-RARRES2', 'RETSAT-downregulated-GSTM2', 'RETSAT-downregulated-PER2', 'MAPK1-involved-FLNA', 'YAP1-involved-FLNA', 'CHI3L1-increase-BMP2', 'AKT1-used-PPARG', 'CD28-diagnosed-FCGR3A', 'FASLG-compare-NPEPPS', 'NPEPPS-compare-BCL2', 'CD8A-diagnosed-FCGR3A', 'FASLG-compare-BCL2', 'CD8A-diagnosed-CD28', 'CD28-diagnosed-LAMP1', 'CD8A-diagnosed-LAMP1', 'SETD2-trigger-ATM', 'SETD2-interact-ATM', 'SIRT1-regulated-CCAR2', 'SIRT1-regulated-TAT', 'GRIA3-increase-GRIP1', 'GDF15-implicated-MAPK14', 'AZU1-compare-CRP', 'GLS-regulated-MAPK8', 'ERRFI1-identified-NDRG1', 'SOCS1-identified-NDRG1', 'IGFBP4-identified-NDRG1', 'BIRC3-identified-NDRG1', 'IRS2-identified-NDRG1', 'PRKAA1-induce-MTOR', 'SIRT1-related-SIRT2', 'SIRT2-identified-SIRT1', 'SIRT2-found-SIRT1', 'RUNX1-bind-TET2', 'CEBPA-bind-TET2', 'Etoposide-substitute-Doxorubicin', 'Calcitriol-consider-Calcifediol', 'Fatty Acids-characterized-Fatty Acids, Omega-3', 'Obesity-compared-Sarcopenia', 'Obesity-correlated-Sarcopenia', 'Obesity-present-Sarcopenia', 'Respiration Disorders-cause-Communicable Diseases', 'Alzheimer Disease-face-Metabolic Diseases', 'Respiratory Insufficiency-reported-Pulmonary Disease, Chronic Obstructive', 'Death-noted-Fragile X Syndrome', 'Breast Neoplasms-discuss-Death', 'Anemia, Sickle Cell-associated-Death', 'Death-associated-Anemia, Sickle Cell', 'Hypertension, Pulmonary-include-Infections', 'Hypertension, Pulmonary-include-Pain', 'HIV Infections-reduce-Chronic Disease', 'Kidney Diseases-include-Pain', 'Inflammation-persist-HIV Infections', 'Aneuploidy-cause-Neoplasms', 'Gilbert Disease-cause-Anemia', 'Gilbert Disease-contribute-Aneuploidy', 'Anemia-contribute-Aneuploidy', 'Neoplasms-reduce-Aneuploidy', 'Aneuploidy-lead-Sotos Syndrome', 'Communicable Diseases-include-Spinal Dysraphism', 'Glycogen Storage Disease Type II-involve-Vision Disorders', 'Vision Disorders-involve-Blindness', 'Skin Diseases-show-Atrophy', 'Immunologic Deficiency Syndromes-associated-Sarcopenia', 'Sarcopenia-associated-Immunologic Deficiency Syndromes', 'Myotonic Dystrophy-recognize-Death', 'Stroke-suffer-Sarcopenia', 'Obesity-achieve-Weight Loss', 'Lung Neoplasms-receive-Death', 'Cross Infection-prevent-Infections', 'Alzheimer Disease-maintain-Corneal Diseases', 'Fatty Liver-maintain-Corneal Diseases', 'Delirium-incorporated-Pain', 'Inflammation-involved-Hypertension', 'Mitochondrial Diseases-contribute-Inflammation', 'Hyperuricemia-affect-Chronic Disease', 'Obesity-found-Diabetes Mellitus', 'Muscular Dystrophy, Duchenne-help-HIV Infections', 'Muscular Dystrophy, Duchenne-help-Osteoporosis', 'Sepsis-predict-Death', 'Sepsis-contribute-Death', 'Neoplasms-defined-Idiopathic Pulmonary Fibrosis', 'Idiopathic Pulmonary Fibrosis-resemble-Hypertension', 'Hereditary Breast and Ovarian Cancer Syndrome-diagnose-Cataract', 'Cataract-consider-Werner Syndrome', 'Cataract-used-Werner Syndrome', 'Werner Syndrome-present-Cataract', 'Werner Syndrome-show-Retinal Diseases', 'Nephrosis, Lipoid-follow-Kidney Diseases', 'Glomerulosclerosis, Focal Segmental-follow-Kidney Diseases', 'Diabetic Nephropathies-follow-Kidney Diseases', 'Cataract-show-Retinal Diseases', 'Hypertension-follow-Kidney Diseases', 'Hematoma, Subdural, Acute-caused-Craniocerebral Trauma', 'Consciousness Disorders-worsen-Nervous System Diseases', 'Inflammation-include-Inflammatory Bowel Diseases', 'Dysbiosis-include-Inflammatory Bowel Diseases', 'Nervous System Diseases-lead-Hypertension', 'Nervous System Diseases-lead-Fibrosis', 'Acute Pain-differ-Pain', 'Pain-applied-Acute Pain', 'Williams Syndrome-included-Scleroderma, Systemic', 'Stroke-examined-Atrial Fibrillation', 'Arbovirus Infections-exacerbate-Pneumonia', 'Osteoarthritis-characterized-Inflammation', 'Joint Diseases-characterized-Inflammation', 'Mastocytosis, Systemic-characterized-Fractures, Bone', 'Inflammatory Bowel Diseases-related-Death', 'Inflammatory Bowel Diseases-increase-Death', 'Obesity-predispose-Embolism', 'Fatigue-associated-Sarcopenia', 'Sarcopenia-associated-Fatigue', 'Fatigue-determined-Sarcopenia', 'Bone Diseases-associate-Osteoporosis', 'Osteoporosis-associate-Bone Diseases', 'Diabetes Mellitus-associate-Osteoporosis', 'Osteoporosis-associate-Diabetes Mellitus', 'Death-diagnose-Dementia', 'Dementia-use-Death', 'Leukemia-classified-Leukemia, Myeloid, Acute', 'Leukemia-classified-Precursor Cell Lymphoblastic Leukemia-Lymphoma', 'Neoplasms-result-Cerebrovascular Disorders', 'Pulmonary Disease, Chronic Obstructive-confirm-Asthma', 'Aneurysm-linked-Ischemia', 'Aneurysm-linked-Diabetes Mellitus', 'Aneurysm-linked-Hyperlipidemias', 'Obesity, Abdominal-remain-Death', 'Cerebral Hemorrhage-prescribed-Brain Injuries, Traumatic', 'Hemorrhage-include-Cerebral Hemorrhage', 'Adenomatous Polyposis Coli-fall-Cardiac Output, Low', 'Glycogen Storage Disease Type II-implicated-Vision Disorders', 'Cardiovascular Diseases-predict-Death', 'Death-present-Respiratory Distress Syndrome', 'Death-present-Dyspnea', 'Severe Acute Respiratory Syndrome-present-Respiratory Distress Syndrome', 'Severe Acute Respiratory Syndrome-present-Dyspnea', 'Hemoglobinopathies-include-alpha-Thalassemia', 'Hemoglobinopathies-include-Thalassemia', 'Ovarian Hyperstimulation Syndrome-create-Kidney Diseases', 'Infections-impart-Death', 'Obesity-increasing-Hypertension', 'Death-persist-Communicable Diseases', 'Glycogen Storage Disease Type II-cause-Vision Disorders', 'Glycogen Storage Disease Type II-lead-Blindness', 'Anophthalmos-lead-Blindness', 'Vision Disorders-lead-Blindness', 'Vaccinia-approved-Infections', 'Atrial Fibrillation-demonstrate-Stroke', 'HIV Infections-associated-Cardiomyopathies', 'Cardiomyopathies-associated-HIV Infections', 'HIV Infections-associated-Hypotension', 'Hypotension-associated-HIV Infections', 'Hypertension-occur-Diabetes Mellitus', 'Acute Kidney Injury-increase-Death', 'Vomiting-noted-Nausea', 'Vomiting-noted-Headache', 'Vomiting-noted-Delirium', 'Vomiting-noted-Hyponatremia', 'Dementia-increase-Adenomatous Polyposis Coli', 'Aneurysm-defined-Atherosclerosis', 'Aneurysm-defined-Angina Pectoris', 'Aneurysm-defined-Myocardial Infarction', 'Aneurysm-defined-Ischemia', 'Cataract-followed-Refractive Errors', 'Aneurysm-defined-Stroke', 'Refractive Errors-followed-Blindness', 'Aneurysm-defined-Headache Disorders, Secondary', 'Glaucoma-followed-Blindness', 'Corneal Opacity-followed-Blindness', 'Atherosclerosis-related-Headache Disorders, Secondary', 'Atherosclerosis-defined-Headache Disorders, Secondary', 'Aneurysm-explain-Stroke', 'Headache Disorders, Secondary-explain-Stroke', 'Ankle Fractures-seen-Wounds and Injuries', 'Atherosclerosis-lead-Cardiovascular Diseases', 'Tibial Neuropathy-relieve-Pain', 'Weight Loss-achieve-Cardiovascular Diseases', 'Weight Loss-reduce-Death', 'Heredodegenerative Disorders, Nervous System-remain-Neurodegenerative Diseases', 'Huntington Disease-drive-Retinal Degeneration', 'Nerve Degeneration-occur-Huntington Disease', 'Osteoarthritis-increase-Obesity', 'Stroke-lead-Lower Extremity Deformities, Congenital', 'Sarcopenia-confirmed-Hip Fractures', 'Nervous System Diseases-observed-Death', 'Pain-confirmed-Nervous System Diseases', 'Neurodegenerative Diseases-account-Nerve Degeneration', 'Death-understand-Asthma', 'Inflammation-contribute-Asthma', 'Asthma-exhibit-Inflammation', 'Asthma-contribute-Lung Diseases', 'Asthma-contribute-Pulmonary Disease, Chronic Obstructive', 'Cold Injury-compare-Death', 'Death-estimated-Cold Injury', 'Death-increase-Cold Injury', 'Death-experience-Cold Injury', 'Arthritis, Rheumatoid-associated-Adrenal Insufficiency', 'Adrenal Insufficiency-associated-Arthritis, Rheumatoid', 'Arthritis, Rheumatoid-associated-Metabolic Diseases', 'Metabolic Diseases-associated-Arthritis, Rheumatoid', 'Wasting Syndrome-characterized-Weight Loss', 'Dementia-base-Atrophy', 'Dementia-use-Atrophy', 'Pulmonary Arterial Hypertension-caused-Pulmonary Heart Disease', 'Atrophy-predict-Dementia', 'Osteoporosis-decrease-Fractures, Bone', 'Osteosarcoma-considered-Neoplasms', 'Death-censor-Cardiovascular Diseases', 'Hip Fractures-prescribed-Osteoporosis', 'Osteoporosis-admitted-Hip Fractures', 'Seizures-establish-Epilepsy', 'Epilepsy-optimize-Seizures', 'Neoplasms-promote-Arbovirus Infections', 'Melanoma-promote-Arbovirus Infections', 'Sarcopenia-estimate-Death', 'Mitochondrial Diseases-assess-Parkinson Disease', 'Asthma-do-Death', 'Weight Loss-include-Neoplasms', 'Fatigue-include-Neoplasms', 'Inflammation-include-Neoplasms', 'Neoplasms-include-Obesity', 'Weight Loss-include-Obesity', 'Fatigue-include-Obesity', 'Inflammation-include-Obesity', 'Obesity-include-Neoplasms', 'Neoplasms-considered-Death', 'Alzheimer Disease-include-Disease', 'Nervous System Diseases-cause-Blindness', 'Glycogen Storage Disease Type II-cause-Blindness', 'Nervous System Diseases-prevent-Vision Disorders', 'Nervous System Diseases-used-Glycogen Storage Disease Type II', 'Vision Disorders-suffer-Glycogen Storage Disease Type II', 'Respiratory Distress Syndrome-related-Infections', 'Sleep Deprivation-result-Memory Disorders', 'Multiple Myeloma-induce-Heart Failure', 'Williams Syndrome-lead-Neoplasms', 'Acro-Osteolysis-diagnosed-Werner Syndrome', 'Dysbiosis-induce-Parkinson Disease', 'Spina Bifida Occulta-involve-Skin Diseases', 'Death-result-Neoplasms', 'Intracranial Aneurysm-account-Rupture', 'Intracranial Aneurysm-account-Subarachnoid Hemorrhage', 'Rupture-account-Subarachnoid Hemorrhage', 'Osteoporosis-transpire-Bone Resorption', 'Obesity, Abdominal-associated-Adrenal Insufficiency', 'Adrenal Insufficiency-associated-Obesity, Abdominal', 'Osteoporosis-transpire-Bone Neoplasms', 'Osteoporosis-transpire-Adrenal Insufficiency', 'Bone Resorption-transpire-Adrenal Insufficiency', 'Bone Neoplasms-transpire-Adrenal Insufficiency', 'Obesity, Abdominal-increase-Adrenal Insufficiency', 'Obesity, Abdominal-increase-Immunologic Deficiency Syndromes', 'Deglutition Disorders-increase-Malnutrition', 'Drug-Related Side Effects and Adverse Reactions-become-Diabetes Mellitus', 'Drug-Related Side Effects and Adverse Reactions-become-Neoplasms', 'Drug-Related Side Effects and Adverse Reactions-become-Cardiovascular Diseases', 'Drug-Related Side Effects and Adverse Reactions-become-Neurodegenerative Diseases', 'Malaria-reflect-Glucosephosphate Dehydrogenase Deficiency', 'Glucosephosphate Dehydrogenase Deficiency-reflect-Hypotension', 'Neoplasms-include-Coronaviridae Infections', 'Diabetes Mellitus-include-Coronaviridae Infections', 'HIV Infections-experience-Bone Diseases, Metabolic', 'Cardiovascular Diseases-include-Coronaviridae Infections', 'HIV Infections-experience-Osteoporosis', 'Fasciculation-include-Glucosephosphate Dehydrogenase Deficiency', 'Hypoxia-perpetuate-Fibrosis', 'Neurologic Manifestations-associated-HIV Infections', 'HIV Infections-associated-Neurologic Manifestations', 'Neurologic Manifestations-impact-HIV Infections', 'Intracranial Aneurysm-lead-Thromboembolism', 'Chronic Pain-accompanied-Sleep Initiation and Maintenance Disorders', 'Pain-become-Diabetes Mellitus', 'Pain-become-Neoplasms', 'Pain-become-Wounds and Injuries', 'Pain-become-Infections', 'Death-cause-Alzheimer Disease', 'Neurodegenerative Diseases-suffer-Alzheimer Disease', 'Neoplasms-present-Communicable Diseases', 'Death-inform-Severe Acute Respiratory Syndrome', 'Alzheimer Disease-induced-Gliosis', 'Alzheimer Disease-show-Communicable Diseases', 'Alzheimer Disease-show-Inflammation', 'Communicable Diseases-show-Inflammation', 'Ischemia-attenuate-Reperfusion Injury', 'Reperfusion Injury-preceded-Hypoxia', 'Hypoxia-attenuate-Reperfusion Injury', 'Reperfusion Injury-attenuate-Ischemia', 'Hypertension-considered-Cardiovascular Diseases', 'Dyslipidemias-considered-Cardiovascular Diseases', 'Infections-develop-Fever', 'Infections-develop-Cough', 'Dyspnea-result-Death', 'Infections-develop-Fatigue', 'Memory Disorders-induced-Inflammation', 'Cardiovascular Diseases-linked-Neurologic Manifestations', 'Diabetes Mellitus-linked-Neurologic Manifestations', 'Neoplasms-linked-Neurologic Manifestations', 'Lung Neoplasms-receive-Neoplasms', 'Neoplasms-suggest-Death', 'Central Nervous System Infections-followed-Cerebrovascular Disorders', 'Neoplasms-associated-Hematologic Neoplasms', 'Hematologic Neoplasms-associated-Neoplasms', 'Cardiomyopathies-result-Heart Failure', 'Neurodegenerative Diseases-result-Nerve Degeneration', 'Cardiomyopathies-result-Arrhythmias, Cardiac', 'Dementia-result-Nerve Degeneration', 'Cardiomyopathies-result-Atrioventricular Block', 'Neoplasms-associated-Cardiomyopathies', 'Cardiomyopathies-associated-Neoplasms', 'Neoplasms-persist-Cardiomyopathies', 'Chronic Disease-begin-Arthritis', 'Alzheimer Disease-account-Dementia', 'Fibrosis-mediated-Inflammation', 'Kearns-Sayre Syndrome-characterise-Glycogen Storage Disease Type II', 'Glycogen Storage Disease Type II-characterise-Retinal Neoplasms', 'Glycogen Storage Disease Type II-show-Vision Disorders', 'Atrophy-show-Vision Disorders', 'Inflammation-play-Glycogen Storage Disease Type II', 'Hypertension-prevent-Neurodegenerative Diseases', 'Neoplasms-downregulated-Chordoma', 'Constriction, Pathologic-lead-Pain', 'Multiple Myeloma-increase-Pain', 'Amnesia-harbor-Nervous System Diseases', 'Dementia-harbor-Nervous System Diseases', 'Alzheimer Disease-associated-Nervous System Diseases', 'Nervous System Diseases-associated-Alzheimer Disease', 'Alzheimer Disease-influence-Nervous System Diseases', 'Death-result-Atrial Fibrillation', 'Cardiovascular Diseases-caused-Atherosclerosis', 'Osteoporosis-defined-Mastocytosis, Systemic', 'Mastocytosis, Systemic-lead-Fractures, Bone', 'Communicable Diseases-increase-Inflammation', 'Respiratory Tract Infections-include-Infections', 'Sarcopenia-reveal-Arthritis, Rheumatoid', 'Chronic Disease-live-Sleep Wake Disorders', 'Chronic Pain-live-Sleep Wake Disorders', 'Critical Illness-reveal-Alzheimer Disease', 'Myalgia-define-Sarcopenia', 'Retinal Arterial Macroaneurysm-cause-Hemorrhage', 'Retinal Arterial Macroaneurysm-lead-Vision Disorders', 'Hemorrhage-lead-Vision Disorders', 'Stroke-include-Communicable Diseases', 'Cataract-account-Vision Disorders', 'Cardiac Output, Low-fall-Sleep Initiation and Maintenance Disorders', 'Cardiac Output, Low-associated-Death', 'Death-associated-Cardiac Output, Low', 'Death-progress-Kidney Failure, Chronic', 'Urinary Bladder, Overactive-include-Urinary Incontinence', 'Prostatic Hyperplasia-defined-Prostatic Neoplasms', 'Urinary Incontinence-identified-Constipation', 'Urinary Incontinence-identified-Obesity', 'Urinary Incontinence-identified-Cough', "Legionnaires' Disease-cause-Legionellosis", 'Fistula-felt-Urinary Incontinence', 'Pulmonary Disease, Chronic Obstructive-associated-Respiratory Tract Diseases', 'Respiratory Tract Diseases-associated-Pulmonary Disease, Chronic Obstructive', 'Infections-place-Death', 'Osteoporosis-caused-Pain', 'Death-use-Hypoxia', 'Cerebrovascular Disorders-followed-Encephalitis', 'Hypoxia-associated-Death', 'Death-associated-Hypoxia', 'Neoplasms-associated-Postoperative Hemorrhage', 'Postoperative Hemorrhage-associated-Neoplasms', 'Delirium-subtyp-Movement Disorders', 'Delirium-subtyp-Hyperkinesis', 'Fractures, Bone-started-Osteoporosis', 'Abdominal Injuries-result-Death', 'Cardiac Output, High-cause-Death', 'Leukemia-suffer-Immune System Diseases', 'Neoplasms-suffer-Immune System Diseases', 'Sarcopenia-occur-Shy-Drager Syndrome', 'Nerve Degeneration-alleviate-Neurodegenerative Diseases', 'Neoplasms-related-Sphingolipidoses', 'Nerve Degeneration-enhance-Alzheimer Disease', 'Nerve Degeneration-enhance-Parkinson Disease', 'Nerve Degeneration-alleviate-Brain Ischemia', 'Chemical and Drug Induced Liver Injury-include-Chronic Disease', 'Liver Failure-associated-Obesity', 'Obesity-associated-Liver Failure', 'Liver Failure-associated-Hypertension', 'Hypertension-associated-Liver Failure', 'Liver Failure-associated-Dyslipidemias', 'Dyslipidemias-associated-Liver Failure', 'Muscular Atrophy-defined-Retinal Degeneration', 'Muscular Atrophy-triggered-Neoplasms', 'Muscular Atrophy-triggered-Wounds and Injuries', 'Muscular Atrophy-triggered-Inflammation', 'Hypoxia-play-Kidney Diseases', 'Hypoxia-inhibit-Pseudohypoparathyroidism', 'Obesity-modulate-Diabetes Mellitus', 'Deafness-hear-Hearing Loss', 'Drug-Related Side Effects and Adverse Reactions-use-Neoplasms', 'Neoplasms-remain-Drug-Related Side Effects and Adverse Reactions', 'Acute Kidney Injury-mark-Death', 'Coinfection-increase-Myocardial Infarction', 'Alzheimer Disease-play-Cerebrovascular Disorders', 'Alzheimer Disease-play-Hereditary Central Nervous System Demyelinating Diseases', 'Thyroid Diseases-present-Muscle Weakness', 'Liver Failure-implicated-Alzheimer Disease', 'Liver Failure-implicated-Liver Diseases', 'Liver Diseases-relate-Ossification of Posterior Longitudinal Ligament', 'Liver Diseases-relate-Alzheimer Disease', 'Liver Diseases-relate-Neurodegenerative Diseases', 'Liver Diseases-associated-Alzheimer Disease', 'Alzheimer Disease-associated-Liver Diseases', 'Liver Diseases-demonstrate-Chemical and Drug Induced Liver Injury', 'Glucose Metabolism Disorders-resemble-Diabetes Mellitus', 'Liver Diseases-accelerate-Brain Diseases', 'Cerebrovascular Disorders-contribute-Cardiovascular Diseases', 'Fractures, Bone-related-Inflammation', 'Cerebrovascular Disorders-reduce-Cardiovascular Diseases', 'Breast Neoplasms-characterized-Neoplasms', 'Hypertension-followed-Diabetes Mellitus', 'Joint Diseases-followed-Hypertension', 'Breast Neoplasms-develop-Neoplasms', 'Neoplasms-develop-Breast Neoplasms', 'Immunologic Deficiency Syndromes-modify-Osteoporosis', 'Adrenal Insufficiency-modify-Osteoporosis', 'Macular Degeneration-occur-Glycogen Storage Disease Type II', 'Astrocytoma-reveal-Glioblastoma', 'Sleep Initiation and Maintenance Disorders-associated-Obesity', 'Obesity-associated-Sleep Initiation and Maintenance Disorders', 'Astrocytoma-reveal-Neoplasms', 'Chronobiology Disorders-find-Obesity', 'Progeria-compare-Polyendocrinopathies, Autoimmune', 'Mitral Valve Insufficiency-compare-Death', 'Arthritis, Rheumatoid-exposed-Drug-Related Side Effects and Adverse Reactions', 'Metabolic Syndrome-consist-Obesity', 'Metabolic Syndrome-consist-Hypertension', 'Metabolic Syndrome-consist-Atherosclerosis', 'Death-descend-Aortic Aneurysm, Thoracic', 'HIV Infections-live-Psychomotor Disorders', 'Mitochondrial Diseases-associated-Progeria', 'Progeria-associated-Mitochondrial Diseases', 'Fractures, Bone-needed-Hip Fractures', 'Tauopathies-suffer-Brain Diseases', 'Tauopathies-pick-Alzheimer Disease', 'Tauopathies-pick-Dementia', 'Neurodegenerative Diseases-afflict-Brain Diseases', 'Neurodegenerative Diseases-suffer-Brain Diseases', 'Neurodegenerative Diseases-pick-Alzheimer Disease', 'Neurodegenerative Diseases-pick-Dementia', 'Renal Insufficiency, Chronic-demonstrate-Death', 'Pleural Diseases-associated-Neoplasms', 'Neoplasms-associated-Pleural Diseases', 'Osteoarthritis-describe-Joint Diseases', 'Diabetes Mellitus, Type 2-prevent-Alzheimer Disease', 'Death-range-Heart Failure', 'Malnutrition-associated-Peripheral Arterial Disease', 'Peripheral Arterial Disease-associated-Malnutrition', 'Psychomotor Disorders-confirm-Hyperthyroidism', 'Headache Disorders, Secondary-confirm-Hyperthyroidism', 'Lupus Nephritis-followed-Diabetic Nephropathies', 'Sarcopenia-investigate-Obesity', 'Sarcopenia-associated-Respiratory System Abnormalities', 'Respiratory System Abnormalities-associated-Sarcopenia', 'Sarcopenia-associated-Heredodegenerative Disorders, Nervous System', 'Heredodegenerative Disorders, Nervous System-associated-Sarcopenia', 'Drug-Related Side Effects and Adverse Reactions-induce-Mitochondrial Diseases', 'Drug-Related Side Effects and Adverse Reactions-associated-Mitochondrial Diseases', 'Mitochondrial Diseases-associated-Drug-Related Side Effects and Adverse Reactions', 'Stomach Neoplasms-investigate-Neoplasms', 'Polycystic Ovary Syndrome-associated-Inflammation', 'Inflammation-associated-Polycystic Ovary Syndrome', 'Endocrine System Diseases-associated-Inflammation', 'Inflammation-associated-Endocrine System Diseases', 'Pancreatitis-cause-Death', 'Necrosis-cause-Death', 'Multiple Organ Failure-cause-Death', 'Pneumonia-increase-Pulmonary Disease, Chronic Obstructive', 'Neurodegenerative Diseases-hinder-Neurotoxicity Syndromes', 'Cystic Fibrosis-result-Lung Diseases', 'Neoplasms-associated-Neurodegenerative Diseases', 'Neurodegenerative Diseases-associated-Neoplasms', 'Neurodegenerative Diseases-associated-Alzheimer Disease', 'Alzheimer Disease-associated-Neurodegenerative Diseases', 'Dementia-associated-Inflammatory Bowel Diseases', 'Inflammatory Bowel Diseases-associated-Dementia', 'Liver Diseases-associated-Rheumatic Diseases', 'Rheumatic Diseases-associated-Liver Diseases', 'Dementia-associated-Rheumatic Diseases', 'Rheumatic Diseases-associated-Dementia', 'Sarcopenia-investigate-Lung Neoplasms', 'Sarcopenia-involved-Lung Neoplasms', 'Sarcopenia-investigate-Carcinoma, Non-Small-Cell Lung', 'Sarcopenia-involved-Carcinoma, Non-Small-Cell Lung', 'Cachexia-accompanied-Muscular Atrophy', 'Cachexia-accompanied-Sarcopenia', 'Cachexia-accompanied-Mitochondrial Diseases', 'Muscular Atrophy-accompanied-Sarcopenia', 'Muscular Atrophy-accompanied-Mitochondrial Diseases', 'Mitochondrial Diseases-include-Sarcopenia', 'Pelvic Neoplasms-identified-Malocclusion', 'Arbovirus Infections-associated-Atherosclerosis', 'Atherosclerosis-associated-Arbovirus Infections', 'HIV Infections-induce-Heart Arrest', 'Atherosclerosis-caused-Arbovirus Infections', 'Breast Neoplasms-remain-Death', 'Canavan Disease-associated-Heredodegenerative Disorders, Nervous System', 'Heredodegenerative Disorders, Nervous System-associated-Canavan Disease', 'Canavan Disease-associated-Alzheimer Disease', 'Alzheimer Disease-associated-Canavan Disease', 'Neurodegenerative Diseases-linked-Lysosomal Storage Diseases', 'Lysosomal Storage Diseases-linked-Neurodegenerative Diseases', 'Skin Diseases-correlate-Eczema', 'Chest Pain-peak-Dyspnea', 'Sepsis-complicated-Diabetes Mellitus', 'Sepsis-complicated-Diabetes Mellitus, Type 2', 'Sepsis-complicated-Hypothyroidism', 'Sepsis-complicated-Hypertension', 'Sepsis-complicated-Kidney Failure, Chronic', 'Sepsis-complicated-Ischemia', 'Sepsis-complicated-Atrial Fibrillation', 'Infections-complicated-Sepsis', 'Alzheimer Disease-speak-Death', 'Hypertension-reclassified-Cardiovascular Diseases', 'Hypertension-reclassified-Diabetes Mellitus', 'Nocturia-caused-Urologic Diseases', 'Nocturia-caused-Mastocytosis, Systemic', 'Heterotaxy Syndrome-associated-Nocturia', 'Nocturia-associated-Heterotaxy Syndrome', 'Nocturia-caused-Heart Diseases', 'Heart Diseases-include-Urologic Diseases', 'Heart Diseases-include-Mastocytosis, Systemic', 'Nocturia-predict-Hypertrophy, Left Ventricular', 'Neurodegenerative Diseases-include-Strabismus', 'Ataxia-defined-Sarcopenia', 'Ataxia-use-Sarcopenia', 'Rosacea-increase-Inflammation', 'Ovarian Diseases-cause-Osteoporosis', 'Infections-modulate-Bone Neoplasms', 'Inflammation-mediate-Bone Neoplasms', 'Inflammation-cause-Osteoporosis', 'Diabetes Mellitus, Type 2-exacerbate-Inflammation', 'Inflammation-play-Diabetes Mellitus', 'Inflammation-play-Cutaneous Fistula', 'Myotonic Dystrophy-characterized-Muscle Weakness', 'Myotonic Dystrophy-characterized-Shy-Drager Syndrome', 'Genetic Diseases, Inborn-characterized-Muscle Weakness', 'Genetic Diseases, Inborn-characterized-Shy-Drager Syndrome', 'Diabetes Mellitus-represent-Metabolic Diseases', 'Weight Loss-indicate-Heart Diseases', 'Death-triggered-Acute Coronary Syndrome', 'Arrhythmias, Cardiac-triggered-Acute Coronary Syndrome', 'Acute Pain-masked-Coronary Artery Disease', 'Acute Pain-appear-Coronary Artery Disease', 'Death-make-Cardiovascular Diseases', 'Neoplasms-contribute-Mastocytosis, Systemic', 'Dyslipidemias-increase-Hypertriglyceridemia', 'Heart Failure-occur-Ischemia', 'Heart Failure-occur-Coronary Artery Disease', 'Kidney Failure, Chronic-identify-Sarcopenia', 'Kidney Failure, Chronic-associated-Sarcopenia', 'Sarcopenia-associated-Kidney Failure, Chronic', 'Sarcopenia-identified-Renal Insufficiency, Chronic', 'Afibrinogenemia-halt-Hemorrhage', 'Heart Failure-stop-Hemorrhage', 'Synovitis-develop-Polymyalgia Rheumatica', 'Edema-develop-Polymyalgia Rheumatica', 'Pain-develop-Polymyalgia Rheumatica', 'Fatigue-develop-Polymyalgia Rheumatica', 'Pelvic Girdle Pain-associated-Asthenia', 'Asthenia-associated-Pelvic Girdle Pain', 'Synovitis-associated-Neoplasms', 'Neoplasms-associated-Synovitis', 'Synovitis-appear-Polymyalgia Rheumatica', 'Edema-appear-Polymyalgia Rheumatica', 'Femoral Fractures-grouped-Fractures, Bone', 'Fractures, Bone-grouped-Hip Fractures', 'Femoral Fractures-grouped-Hip Fractures', 'Infections-require-Chemical and Drug Induced Liver Injury', 'Infections-remain-Sleep Disorders, Circadian Rhythm', 'Chemical and Drug Induced Liver Injury-seen-Sleep Disorders, Circadian Rhythm', 'Hypogonadism-fulfilled-Huntington Disease', 'Erectile Dysfunction-decrease-Huntington Disease', 'Obesity-increase-Osteoporosis', 'Inflammation-delineated-Thrombosis', 'Colonic Diseases-show-Death', 'Heart Arrest-measured-Alzheimer Disease', 'Alzheimer Disease-characterized-Dementia', 'Infections-seem-Prostatitis', 'Death-hospitalized-Hernia', 'Gangrene-associated-Death', 'Death-associated-Gangrene', 'Death-admitted-Hernia', 'Neck Pain-experience-Uterine Cervicitis', 'Neck Pain-experience-Spinal Cord Diseases', 'Myotonic Dystrophy-use-Diabetes Mellitus', 'Myotonic Dystrophy-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-Myotonic Dystrophy', 'Muscular Atrophy-associated-Multiple Myeloma', 'Multiple Myeloma-associated-Muscular Atrophy', 'Prader-Willi Syndrome-associated-Multiple Myeloma', 'Multiple Myeloma-associated-Prader-Willi Syndrome', 'Macular Degeneration-decreased-Parkinson Disease', 'Death-made-Machado-Joseph Disease', 'Salmonella Infections-lead-Infections', 'Infections-lead-Sepsis', 'Dysuria-diagnosed-Urinary Bladder, Neurogenic', 'Dysuria-diagnosed-Cystitis', 'Rectal Diseases-alleviated-Low Back Pain', 'Sarcopenia-diagnosed-Muscular Diseases', 'White Dot Syndromes-cause-Vision Disorders', 'Leukemia, Myeloid-share-Leukemia, Myeloid, Acute', 'Death-live-Dementia', 'Obesity-generate-Metabolic Syndrome', 'Obesity-generate-Diabetes Mellitus', 'Obesity-generate-Hypertension', 'Obesity-generate-Cardiovascular Diseases', 'Obesity-generate-Neoplasms', 'Obesity-generate-Neurodegenerative Diseases', 'Spinal Cord Diseases-associated-Death', 'Death-associated-Spinal Cord Diseases', 'Sarcopenia-characterized-Muscular Atrophy', 'Neuromuscular Diseases-characterized-Muscular Atrophy', 'Neutropenia-include-Neoplasms', 'Anemia-include-Neoplasms', 'Thrombocytopenia-include-Neoplasms', 'Lymphopenia-include-Neoplasms', 'Mucositis-include-Neoplasms', 'Drug-Related Side Effects and Adverse Reactions-contribute-Death', 'Drug-Related Side Effects and Adverse Reactions-contribute-Neoplasms', 'Mucositis-include-Drug-Related Side Effects and Adverse Reactions', 'Diarrhea-include-Drug-Related Side Effects and Adverse Reactions', 'Pulmonary Disease, Chronic Obstructive-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-Pulmonary Disease, Chronic Obstructive', 'Cerebral Small Vessel Diseases-promoted-Hypertension', 'Prehypertension-found-Hypertension', 'Hypercholesterolemia-correlated-Hypertension', 'Glaucoma-understand-Nervous System Diseases', 'Syncope-divided-Heart Arrest', 'Heart Arrest-begin-Unconsciousness', 'Thrombophilia-associated-Venous Thromboembolism', 'Venous Thromboembolism-associated-Thrombophilia', 'Osteoporosis-provide-Headache Disorders, Secondary', 'Death-hospitalize-Arthritis, Infectious', 'Death-increase-Heart Failure', 'Death-increase-Dementia', 'Death-increase-Myocardial Infarction', 'Death-increase-Renal Insufficiency, Chronic', 'Arthritis, Infectious-hospitalize-Heart Failure', 'Arthritis, Infectious-hospitalize-Dementia', 'Arthritis, Infectious-hospitalize-Myocardial Infarction', 'Arthritis, Infectious-hospitalize-Renal Insufficiency, Chronic', 'Dementia-associated-Sleepiness', 'Sleepiness-associated-Dementia', 'Death-found-Heart Failure', 'Arrhythmias, Cardiac-followed-Heart Failure', 'Rhinitis-compare-Bronchitis', 'Asthma-compare-Bronchitis', 'HIV Infections-associated-Chronic Disease', 'Chronic Disease-associated-HIV Infections', 'Weight Loss-associated-Fractures, Bone', 'Fractures, Bone-associated-Weight Loss', 'Muscular Dystrophy, Duchenne-develop-Fractures, Bone', 'Fractures, Bone-surpass-Diabetes Mellitus', 'Fractures, Bone-surpass-Hypertension', 'Death-surpass-Diabetes Mellitus', 'Death-surpass-Hypertension', 'Glomerulosclerosis, Focal Segmental-lower-Proteinuria', 'Proteinuria-ameliorate-Glomerulosclerosis, Focal Segmental', 'Albuminuria-defined-Acute Kidney Injury', 'Albuminuria-indicate-Acute Kidney Injury', 'Multiple Myeloma-inhibit-Neoplasms', 'Hyperoxia-cause-Drug-Related Side Effects and Adverse Reactions', 'Cerebrovascular Disorders-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-Cerebrovascular Disorders', 'Fractures, Bone-use-Hip Fractures', 'Genetic Diseases, Inborn-classified-Aortic Aneurysm, Thoracic', 'Atherosclerosis-play-Mitochondrial Diseases', 'Genetic Diseases, Inborn-related-Hypertension', 'Aortic Aneurysm, Thoracic-manage-Hypertension', 'Pneumonia-observed-Bronchopneumonia', 'Infections-linked-Death', 'Infections-show-Lung Diseases', 'Alzheimer Disease-identify-Osteoporosis', 'Fractures, Bone-recommended-Osteoporosis', 'Fractures, Bone-identify-Osteoporosis', 'Fatty Liver-recommended-Osteoporosis', 'Fatty Liver-identify-Osteoporosis', 'Hyperglycemia-reduce-Diabetes Mellitus', 'Muscular Atrophy-accelerate-Critical Illness', 'Sarcopenia-accentuate-Obesity', 'Arrhythmias, Cardiac-intertwined-Atrial Fibrillation', 'Atrial Fibrillation-intertwined-Metabolic Diseases', 'Arrhythmias, Cardiac-intertwined-Metabolic Diseases', 'Obesity-underestimate-Fractures, Bone', 'Chronic Disease-associated-Stroke', 'Stroke-associated-Chronic Disease', 'Hearing Disorders-lead-Hearing Loss, Central', 'Nerve Degeneration-lead-Hearing Loss, Central', 'Inflammatory Bowel Diseases-defined-Colitis, Ulcerative', 'Osteoarthritis-lead-Cartilage Diseases', 'Joint Diseases-lead-Cartilage Diseases', 'Chronic Disease-rise-Obesity', 'Cardiovascular Diseases-rise-Obesity', 'Memory Disorders-associated-Fractures, Bone', 'Fractures, Bone-associated-Memory Disorders', 'Atrial Fibrillation-decrease-Death', 'Heart Failure-decrease-Death', 'Osteoporotic Fractures-defined-Glucose Intolerance', 'Cataract-associated-Astigmatism', 'Astigmatism-associated-Cataract', 'Myopia-associated-Astigmatism', 'Astigmatism-associated-Myopia', 'Critical Illness-develop-Muscular Atrophy', 'Peripheral Arterial Disease-caused-Atherosclerosis', 'Muscular Atrophy-reduce-Critical Illness', 'Sleep Wake Disorders-associate-Metabolic Diseases', 'Metabolic Diseases-associate-Sleep Wake Disorders', 'Infections-mediate-Sleep Wake Disorders', 'Stroke, Lacunar-associated-Kidney Diseases', 'Kidney Diseases-associated-Stroke, Lacunar', 'Kidney Diseases-predict-Infarction', 'Marfan Syndrome-associated-Stroke, Lacunar', 'Stroke, Lacunar-associated-Marfan Syndrome', 'Inflammation-link-Obesity', 'Inflammation-link-Pain', 'Obesity-link-Pain', 'Fatty Liver-become-Liver Diseases', 'Fatty Liver-become-Fibrosis', 'Liver Diseases-become-Fibrosis', 'Fever-followed-Cough', 'Diabetes Mellitus-dominate-Hypertension', 'Mitochondrial Diseases-associated-Idiopathic Pulmonary Fibrosis', 'Idiopathic Pulmonary Fibrosis-associated-Mitochondrial Diseases', 'Hyperlipidemias-dominate-Hypertension', 'Hyperuricemia-dominate-Hypertension', 'Osteoporosis-dominate-Hypertension', 'Pulmonary Disease, Chronic Obstructive-dominate-Hypertension', 'Prediabetic State-diagnosed-Diabetes Mellitus', 'Metabolism, Inborn Errors-represent-Immunologic Deficiency Syndromes', 'Death-driven-Respiratory Tract Diseases', 'Cough-relieve-Asthma', 'Death-reflect-Adenomatous Polyposis Coli', 'Wounds and Injuries-exhibit-Inflammation', 'Wounds and Injuries-exhibit-Blood Coagulation Disorders', 'Blood Coagulation Disorders-include-Inflammation', 'Sarcopenia-identified-Obesity', 'Wounds and Injuries-lead-Death', 'Cardiovascular Diseases-increase-Chronic Kidney Disease-Mineral and Bone Disorder', 'Cardiovascular Diseases-increase-Heart Failure', 'Chronic Kidney Disease-Mineral and Bone Disorder-increase-Heart Failure', 'Stroke-accompanied-Cardiac Complexes, Premature', 'Death-undergo-Stomach Neoplasms', 'Stroke-accompanied-Delirium', 'Death-undergo-Pancreatic Diseases', 'Death-undergo-Esophageal Neoplasms', 'Cardiac Output, Low-associated-Hip Fractures', 'Hip Fractures-associated-Cardiac Output, Low', 'Stroke-suggest-Leukoaraiosis', 'Respiratory Insufficiency-result-Death', 'Pain, Postoperative-underlie-Sleep Wake Disorders', 'Sarcopenia-determine-Osteoarthritis', 'Chemical and Drug Induced Liver Injury-include-Death', 'Zellweger Syndrome-forecast-Dementia', 'Zellweger Syndrome-forecast-Alzheimer Disease', 'Infections-cause-Periodontitis', 'Infections-cause-Inflammation', 'Infections-cause-Chronic Disease', 'Periodontitis-cause-Inflammation', 'Inflammation-cause-Chronic Disease', 'Periodontitis-demonstrate-Diabetes Mellitus', 'Osteoporosis-cause-Osteoporotic Fractures', 'Osteoporosis-occur-Death', 'Fatigue-follow-Pruritus', 'Pain-occur-Hypoxia', 'Pain-occur-Cough', 'Dyspnea-include-Musculoskeletal Pain', 'Cough-include-Musculoskeletal Pain', 'Inflammatory Bowel Diseases-suffer-Alzheimer Disease', 'Alzheimer Disease-aggravate-Inflammatory Bowel Diseases', 'Inflammatory Bowel Diseases-targeting-Alzheimer Disease', 'Immunologic Deficiency Syndromes-thought-Blood Coagulation Disorders', 'Immunologic Deficiency Syndromes-consider-Chemical and Drug Induced Liver Injury', 'Blood Coagulation Disorders-show-Hemorrhage', 'Blood Coagulation Disorders-consider-Chemical and Drug Induced Liver Injury', 'Pain-block-Nausea', 'Low Back Pain-block-Nausea', 'Hypertension-observed-Ventricular Remodeling', 'Ventricular Remodeling-induced-Hypertension', 'Pain-reported-Fractures, Open', 'Hypertension-recognized-Heart Failure', 'Cardiovascular Diseases-linked-Diabetes Mellitus', 'Hypertension-recognized-Atrial Fibrillation', 'Hypertension-provoke-Stroke', 'Atherosclerosis-develop-Cardiovascular Diseases', 'Sarcopenia-modify-Death', 'Sarcopenia-assess-Death', 'Ovarian Diseases-result-Infertility, Female', 'Colorectal Neoplasms-reduce-Neoplasms', 'Colonic Polyps-reduce-Neoplasms', 'Muscular Atrophy-accompanied-Death', 'Wounds and Injuries-triggered-Diabetes Mellitus', 'Wounds and Injuries-triggered-Infections', 'Pain-control-Inflammation', 'Joint Diseases-reduce-Myalgia', 'Joint Diseases-prevent-Dyskinesia, Drug-Induced', 'Myalgia-prevent-Dyskinesia, Drug-Induced', 'Urinary Incontinence-fall-Cardiac Output, Low', 'Postpartum Hemorrhage-tolerated-Anemia', 'Heart Failure-tolerate-Anemia', 'Cerebrovascular Disorders-tolerate-Anemia', 'Anemia-include-Malnutrition', 'Anemia-include-Chronic Disease', 'Anemia-include-Leukemia, Lymphocytic, Chronic, B-Cell', 'Anemia-include-Multiple Myeloma', 'Anemia-include-Myelodysplastic Syndromes', 'Fractures, Bone-assess-Pain, Postoperative', 'Diabetes Mellitus-reduce-Cardiomyopathy, Dilated', 'Muscular Atrophy-caused-Cachexia', 'Muscular Atrophy-result-Muscular Diseases', 'Cachexia-result-Muscular Diseases', 'Obesity-derived-Osteoporotic Fractures', 'Cachexia-represent-Multiple Organ Failure', 'Cachexia-associated-Neoplasms', 'Neoplasms-associated-Cachexia', 'Cachexia-associated-Chronic Disease', 'Chronic Disease-associated-Cachexia', 'Multiple Organ Failure-associated-Neoplasms', 'Neoplasms-associated-Multiple Organ Failure', 'Multiple Organ Failure-associated-Chronic Disease', 'Chronic Disease-associated-Multiple Organ Failure', 'Muscular Diseases-known-Sarcopenia', 'Cachexia-understand-Muscular Atrophy', 'Sarcopenia-understand-Muscular Atrophy', 'Infections-reduce-Death', 'Weight Loss-prevent-Death', 'Diabetes Mellitus-related-Inflammation', 'Sepsis-include-Infections', 'Shock-delay-Diabetes Mellitus', 'Arthritis, Rheumatoid-use-Arthritis', 'Respiratory Insufficiency-obtained-Sarcopenia', 'Sarcopenia-associate-Cardiac Output, Low', 'Cardiac Output, Low-associate-Sarcopenia', 'Memory Disorders-include-Constipation', 'Alzheimer Disease-include-Brain Diseases', 'Dementia-include-Brain Diseases', 'Cough-show-Dyspnea', 'Aortic Diseases-reported-Alzheimer Disease', 'Aortic Diseases-amyloid-Alzheimer Disease', 'Ageusia-show-Dyspnea', 'Inflammation-induced-HIV Infections', 'Fibrosis-resemble-Cardiovascular Abnormalities', 'Prostatic Neoplasms-arise-Neoplasms', 'Cerebral Infarction-occur-Death', 'Atrial Fibrillation-occur-Death', 'Opportunistic Infections-lead-Death', 'Chronic Kidney Disease-Mineral and Bone Disorder-increase-Death', 'Blood Protein Disorders-referred-Synucleinopathies', 'Cardiovascular Diseases-predict-Sexual Dysfunction, Physiological', 'Asthma-characterized-Dyspnea', 'Chronic Disease-characterized-Dyspnea', 'Seizures-surplus-Death', 'Vision Disorders-associated-Cataract', 'Cataract-associated-Vision Disorders', 'Chronic Disease-associated-Vision Disorders', 'Vision Disorders-associated-Chronic Disease', 'Myocardial Infarction-show-Atherosclerosis', 'Cardiovascular Diseases-account-Atherosclerosis', 'Heart Diseases-followed-Low Back Pain', 'Melanoma-informed-Neoplasms', 'Melanoma-represent-Neoplasms', 'Leukemia, Myeloid, Acute-identify-Drug-Related Side Effects and Adverse Reactions', 'Neoplasms-group-Infections', 'Hypoxia-hinder-Alzheimer Disease', 'Abnormalities, Drug-Induced-associated-Inflammation', 'Inflammation-associated-Abnormalities, Drug-Induced', 'Abnormalities, Drug-Induced-associated-Arthritis, Rheumatoid', 'Arthritis, Rheumatoid-associated-Abnormalities, Drug-Induced', 'Abnormalities, Drug-Induced-associated-Osteoarthritis', 'Osteoarthritis-associated-Abnormalities, Drug-Induced', 'Abnormalities, Drug-Induced-associated-Asthma', 'Asthma-associated-Abnormalities, Drug-Induced', 'Abnormalities, Drug-Induced-associated-Coronary Artery Disease', 'Coronary Artery Disease-associated-Abnormalities, Drug-Induced', 'Neurodegenerative Diseases-studied-Alzheimer Disease', 'Abnormalities, Drug-Induced-associated-Arrhythmias, Cardiac', 'Arrhythmias, Cardiac-associated-Abnormalities, Drug-Induced', 'Abnormalities, Drug-Induced-associated-Obesity', 'Obesity-associated-Abnormalities, Drug-Induced', 'Abnormalities, Drug-Induced-associated-Diabetes Mellitus, Type 2', 'Diabetes Mellitus, Type 2-associated-Abnormalities, Drug-Induced', 'Heart Diseases-reduced-Lung Diseases', 'Dementia-identify-Alzheimer Disease', 'Hematoma-include-Seizures', 'Hematoma-tied-Seizures', 'Hypertension-tied-Seizures', 'Mitochondrial Diseases-include-Drug-Related Side Effects and Adverse Reactions', 'Hypertension-follow-Diabetes Mellitus', 'Hypertension-follow-Coronary Artery Disease', 'Hypertension-follow-Cerebrovascular Disorders', 'Hypertension-represent-Death', 'Hyperglycemia-play-Diabetes Mellitus', 'Sarcopenia-associated-Atrial Fibrillation', 'Atrial Fibrillation-associated-Sarcopenia', 'Malnutrition-associated-Atrial Fibrillation', 'Atrial Fibrillation-associated-Malnutrition', 'Infections-related-Dementia', 'Infections-caused-Dementia', 'Heart Failure-linked-Death', 'Cardiovascular Diseases-increase-Cardiac Output, High', 'Immune System Diseases-reported-Arbovirus Infections', 'Immune System Diseases-reported-Neoplasms', 'Dementia-develop-Parkinson Disease, Secondary', 'Atrial Fibrillation-followed-Airway Obstruction', 'Atrial Fibrillation-include-Airway Obstruction', 'Airway Obstruction-shown-Heart Failure', 'Airway Obstruction-relieve-Atrial Fibrillation', 'Mitral Valve Insufficiency-shown-Heart Failure', 'Mitral Valve Insufficiency-relieve-Atrial Fibrillation', 'Heart Failure-shown-Atrial Fibrillation', 'Pigmentation Disorders-vary-Glycogen Storage Disease Type II', 'Pigmentation Disorders-used-Glycogen Storage Disease Type II', 'Glycogen Storage Disease Type II-polarize-Pigmentation Disorders', 'Chemical and Drug Induced Liver Injury-associated-Glycogen Storage Disease Type II', 'Glycogen Storage Disease Type II-associated-Chemical and Drug Induced Liver Injury', 'Inflammation-linked-Bone Neoplasms', 'Muscular Dystrophy, Duchenne-increase-Osteoporosis', 'Multiple Myeloma-show-Drug-Related Side Effects and Adverse Reactions', 'Lymphoma-target-Multiple Myeloma', 'Hypertension-lead-Death', 'Death-used-Pancreatitis', 'Nervous System Diseases-recognized-Neuralgia', 'Death-related-Pancreatitis', 'Dementia-seen-Parkinson Disease', 'Sarcopenia-linked-Heredodegenerative Disorders, Nervous System', 'Psychomotor Disorders-associated-Leukemia, Myeloid, Acute', 'Leukemia, Myeloid, Acute-associated-Psychomotor Disorders', 'Coronary Artery Disease-carry-Death', 'Obesity-result-Coronary Artery Disease', 'Diabetes Mellitus-result-Coronary Artery Disease', 'Hemorrhage-need-Urethral Diseases', 'Obesity, Abdominal-compare-Flatfoot', 'HIV Infections-remain-Nerve Degeneration', 'HIV Infections-associated-AIDS Arteritis, Central Nervous System', 'AIDS Arteritis, Central Nervous System-associated-HIV Infections', 'Adenomatous Polyposis Coli-associated-Dementia', 'Dementia-associated-Adenomatous Polyposis Coli', 'Constipation-treat-Neoplasms', 'Chemical and Drug Induced Liver Injury-treat-Neoplasms', 'Arteriosclerosis-treat-Neoplasms', 'Chemical and Drug Induced Liver Injury-treat-Constipation', 'Arteriosclerosis-treat-Constipation', 'Neurodegenerative Diseases-include-Inflammation', 'Alzheimer Disease-include-Inflammation', 'Parkinson Disease-include-Inflammation', 'Cardiovascular Diseases-include-Inflammation', 'Myotonic Dystrophy-include-Inflammation', 'Renal Insufficiency, Chronic-include-Inflammation', 'Chronic Kidney Disease-Mineral and Bone Disorder-include-Inflammation', 'Parkinson Disease-include-Neurodegenerative Diseases', 'Cardiovascular Diseases-include-Neurodegenerative Diseases', 'Diabetes Mellitus-include-Neurodegenerative Diseases', 'Myotonic Dystrophy-include-Neurodegenerative Diseases', 'Renal Insufficiency, Chronic-include-Neurodegenerative Diseases', 'Chronic Kidney Disease-Mineral and Bone Disorder-include-Neurodegenerative Diseases', 'Retinal Degeneration-implicated-Vision Disorders', 'Cardiovascular Diseases-occupy-Death', 'Death-reduce-Breast Neoplasms', 'Hypertension-reduce-Death', 'Cleidocranial Dysplasia-reinforce-Alzheimer Disease', 'Leukemia-play-Leukemia, Myeloid, Acute', 'Parkinson Disease-matched-Pain', 'Parkinson Disease-matched-Back Pain', 'Radiculopathy-demonstrate-Parkinson Disease', 'Venous Thromboembolism-occur-Hemorrhage', 'Thromboembolism-occur-Hemorrhage', 'Genetic Diseases, Inborn-characterized-Death', 'Fucosidosis-apply-Learning Disabilities', 'Hypertension-develop-Alzheimer Disease', 'Hypertension-thought-Death', 'Alzheimer Disease-decreased-Nerve Degeneration', 'Atherosclerosis-driven-Hyperlipidemias', 'Atherosclerosis-driven-Inflammation', 'Cardiovascular Diseases-driven-Hyperlipidemias', 'Cardiovascular Diseases-driven-Inflammation', 'Osteoporosis-result-Immunologic Deficiency Syndromes', 'Immunologic Deficiency Syndromes-increase-Fractures, Bone', 'Drug-Related Side Effects and Adverse Reactions-develop-Neoplasms', 'Neoplasms-develop-Drug-Related Side Effects and Adverse Reactions', 'Stroke-diagnosed-Dementia, Vascular', 'Parkinson Disease-include-Nervous System Diseases', 'Liver Cirrhosis-related-Fatty Liver', 'Sclerosis-include-Nervous System Diseases', 'Alzheimer Disease-include-Nervous System Diseases', 'Immunologic Deficiency Syndromes-associated-Hearing Loss', 'Hearing Loss-associated-Immunologic Deficiency Syndromes', 'Immunologic Deficiency Syndromes-associated-Hearing Loss, Central', 'Hearing Loss, Central-associated-Immunologic Deficiency Syndromes', 'Immunologic Deficiency Syndromes-occur-Hearing Loss, Central', 'Hearing Loss-hear-Hearing Loss, Central', 'Death-sustain-Wounds and Injuries', 'Myocardial Infarction-combined-Liver Failure, Acute', 'Respiratory Distress Syndrome-do-Lethargy', 'Biliary Tract Diseases-suspected-Bacteremia', 'Gitelman Syndrome-reduce-Fractures, Bone', 'Adenomatous Polyposis Coli-reduce-Fractures, Bone', 'Cardiac Output, Low-reversed-Adenomatous Polyposis Coli', 'Leprosy-diagnosed-Chromoblastomycosis', 'Diabetes Mellitus-become-Diabetic Foot', 'Diabetes Mellitus-become-Ulcer', 'Wounds and Injuries-suffer-Parkinson Disease', 'Death-suffer-Parkinson Disease', 'Heredodegenerative Disorders, Nervous System-suffer-Parkinson Disease', 'Cerebral Amyloid Angiopathy-co-occur-Alzheimer Disease', 'Aortic Diseases-accelerate-Dementia', 'Alzheimer Disease-accelerate-Dementia', 'Parkinson Disease-point-Inflammation', 'Memory Disorders-show-Alzheimer Disease', 'Nerve Degeneration-promote-Alzheimer Disease', 'Psoriasis-include-Skin Diseases', 'Eczema-include-Skin Diseases', 'Epidermal Cyst-contribute-Inflammation', 'Death-use-Carcinoma, Hepatocellular', 'Death-use-Fibrosis', 'Death-use-Hepatitis B', 'Neoplasms-receive-End Stage Liver Disease', 'End Stage Liver Disease-diagnosed-Neoplasms', 'Arbovirus Infections-employ-Infections', 'Headache Disorders, Secondary-prevent-Fractures, Bone', 'Sarcopenia-associated-Carcinoma, Non-Small-Cell Lung', 'Carcinoma, Non-Small-Cell Lung-associated-Sarcopenia', 'Acromegaly-associated-Arthritis', 'Arthritis-associated-Acromegaly', 'Acromegaly-associated-Carpal Tunnel Syndrome', 'Carpal Tunnel Syndrome-associated-Acromegaly', 'Acromegaly-associated-Metabolic Diseases', 'Metabolic Diseases-associated-Acromegaly', 'Acromegaly-associated-Gastrointestinal Diseases', 'Gastrointestinal Diseases-associated-Acromegaly', 'Death-compare-Sleep Initiation and Maintenance Disorders', 'Sjogren-Larsson Syndrome-associated-Metabolic Diseases', 'Metabolic Diseases-associated-Sjogren-Larsson Syndrome', 'Sjogren-Larsson Syndrome-associated-Alzheimer Disease', 'Alzheimer Disease-associated-Sjogren-Larsson Syndrome', 'Inflammation-promote-Neoplasms', 'Wounds and Injuries-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-Wounds and Injuries', 'Bone Diseases, Metabolic-control-Hyperlipidemias', 'Osteoporosis-control-Hyperlipidemias', 'Death-used-Diabetes Mellitus', 'Death-test-Diabetes Mellitus', 'Pneumonia-delineate-Pulmonary Disease, Chronic Obstructive', 'Heart Diseases-related-Breast Neoplasms', 'Heart Diseases-related-Neoplasms', 'Perceptual Disorders-reflect-Learning Disabilities', 'Stroke-comprise-Dementia', 'Diabetes Mellitus-comprise-Dementia', 'Chronic Pain-diagnose-Dementia', 'Calcinosis-associated-Diabetic Angiopathies', 'Diabetic Angiopathies-associated-Calcinosis', 'Periodontitis-contribute-Neurodegenerative Diseases', 'Inflammation-contribute-Neurodegenerative Diseases', 'Inflammation-show-Neurodegenerative Diseases', 'Periodontal Diseases-initiate-Alzheimer Disease', 'Parkinson Disease-preceded-Signs and Symptoms, Digestive', 'Hereditary Breast and Ovarian Cancer Syndrome-related-Hypertension', 'Hereditary Breast and Ovarian Cancer Syndrome-related-Cerebral Small Vessel Diseases', 'Hereditary Breast and Ovarian Cancer Syndrome-related-Leukoencephalopathies', 'Hereditary Breast and Ovarian Cancer Syndrome-related-Hemostatic Disorders', 'Hereditary Breast and Ovarian Cancer Syndrome-related-Inflammation', 'Lupus Erythematosus, Systemic-enable-Neoplasms', 'Myelodysplastic Syndromes-result-Hypotension', 'Fractures, Bone-examined-Death', 'Severe Acute Respiratory Syndrome-include-Zoonoses', 'Hypotension, Orthostatic-related-Nervous System Diseases', 'Digestive System Neoplasms-remain-Adenocarcinoma', 'Kidney Diseases-associated-Hypertrophy, Left Ventricular', 'Hypertrophy, Left Ventricular-associated-Kidney Diseases', 'Kidney Diseases-increase-Death', 'Hypertrophy, Left Ventricular-increase-Death', 'Nerve Degeneration-associated-HIV Infections', 'HIV Infections-associated-Nerve Degeneration', 'HIV Infections-interact-Neurodegenerative Diseases', 'Leukoencephalopathies-linked-Alzheimer Disease', 'Anemia, Sickle Cell-assess-Alzheimer Disease', 'Liver Diseases-cause-Fibrosis', 'Hypertension-prevent-Tooth Loss', 'Parkinson Disease-modulate-Drug-Related Side Effects and Adverse Reactions', 'Nervous System Diseases-linked-Parkinson Disease', 'Muscular Atrophy-include-Neurologic Manifestations', 'Nerve Degeneration-include-Neurologic Manifestations', 'Huntington Disease-aimed-Sarcopenia', 'Cerebrovascular Disorders-occur-Neurodegenerative Diseases', 'Mastocytosis, Systemic-act-Hypertension', 'Mastocytosis, Systemic-act-Hyperglycemia', 'Mastocytosis, Systemic-act-Dyslipidemias', 'Mastocytosis, Systemic-act-Sleep Wake Disorders', 'Pain-predict-Death', 'Aortic Aneurysm-complicated-Hypovolemia', 'Aortic Aneurysm-complicated-Myocardial Infarction', 'Malnutrition-reduce-Chronic Disease', 'Sleep Wake Disorders-culminate-Respiratory Insufficiency', 'Hypoventilation-culminate-Respiratory Insufficiency', 'Respiratory Insufficiency-associated-Muscular Dystrophy, Duchenne', 'Muscular Dystrophy, Duchenne-associated-Respiratory Insufficiency', 'Fibrosis-investigate-Dementia', 'Neurologic Manifestations-associated-Wounds and Injuries', 'Wounds and Injuries-associated-Neurologic Manifestations', 'Neurologic Manifestations-associated-Alzheimer Disease', 'Alzheimer Disease-associated-Neurologic Manifestations', 'Fatigue-show-Fractures, Bone', 'Neoplasms-explain-Lymphoma, T-Cell', 'Colorectal Neoplasms-calculate-Neoplasms', 'Immunologic Deficiency Syndromes-associated-Carcinogenesis', 'Carcinogenesis-associated-Immunologic Deficiency Syndromes', 'Hearing Loss-characterized-Hearing Loss, Central', 'Glaucoma-occur-Vision Disorders', 'Glaucoma-affect-Vision Disorders', 'Cardiovascular Diseases-observed-Genetic Diseases, Inborn', 'Cardiovascular Diseases-present-Death', 'Sarcopenia-play-Mitochondrial Diseases', 'Mycoses-cause-Death', 'Infections-compared-Diabetes Mellitus', 'Diabetes Mellitus-trigger-Obesity', 'Infections-trigger-Obesity', 'Infections-trigger-Diabetes Mellitus', 'Acquired Immunodeficiency Syndrome-require-Headache Disorders, Secondary', 'Retinal Diseases-judged-Birdshot Chorioretinopathy', 'Common Variable Immunodeficiency-predispose-Immunologic Deficiency Syndromes', 'Immunologic Deficiency Syndromes-fail-Primary Immunodeficiency Diseases', 'Hypertension-associated-Melanoma', 'Melanoma-associated-Hypertension', 'Hyperglycemia-trigger-Dyslipidemias', 'Hyperglycemia-accelerate-Cataract', 'Dyslipidemias-lead-Cataract', 'Hypercholesterolemia-demonstrate-Cataract', 'Hypercholesterolemia-demonstrate-Hyperglycemia', 'Hypertriglyceridemia-demonstrate-Cataract', 'Hypertriglyceridemia-demonstrate-Hyperglycemia', 'Neoplasms-increasing-Death', 'Lymphoma, T-Cell-include-Hereditary Breast and Ovarian Cancer Syndrome', 'Neoplasms-include-Hereditary Breast and Ovarian Cancer Syndrome', 'Atrial Fibrillation-include-Renal Insufficiency', 'Neurologic Manifestations-linked-Idiopathic Pulmonary Fibrosis', 'Neurologic Manifestations-linked-Emphysema', 'Lung Diseases-linked-Idiopathic Pulmonary Fibrosis', 'Lung Diseases-linked-Emphysema', 'Thrombosis-cause-Embolism', 'Thrombosis-cause-Stroke', 'Embolism-cause-Stroke', 'Atrial Fibrillation-cause-Thrombosis', 'Atrial Fibrillation-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-Atrial Fibrillation', 'Atrial Fibrillation-associated-Thyroid Diseases', 'Thyroid Diseases-associated-Atrial Fibrillation', 'Alzheimer Disease-impair-Memory Disorders', 'Neurodegenerative Diseases-impair-Memory Disorders', 'Stroke-associated-Migraine Disorders', 'Migraine Disorders-associated-Stroke', 'Death-occur-Blood Coagulation Disorders', 'Death-associated-Migraine Disorders', 'Migraine Disorders-associated-Death', 'Blood Coagulation Disorders-related-Neoplasms', 'Blood Coagulation Disorders-occur-Migraine Disorders', 'Migraine Disorders-associated-Communicable Diseases', 'Communicable Diseases-associated-Migraine Disorders', 'Obesity-investigate-Muscular Dystrophy, Duchenne', 'Sarcopenia-investigate-Muscular Dystrophy, Duchenne', 'Foot Ulcer-diagnose-Sarcopenia', 'Sarcopenia-affect-Upper Extremity Deformities, Congenital', 'Pneumonia, Pneumocystis-occur-HIV Infections', 'Pneumonia, Pneumocystis-show-Death', 'HIV Infections-occur-Pneumonia, Pneumocystis', 'HIV Infections-show-Death', 'Pneumonia-used-Dysbiosis', 'Pneumonia-used-Pneumonia, Pneumocystis', 'Osteogenesis Imperfecta-prevent-Bone Diseases, Metabolic', 'Alzheimer Disease-exhibit-Cardiac Output, Low', 'Dementia-exhibit-Cardiac Output, Low', 'Hydrocephalus-found-Dementia', 'Death-seen-Substance-Related Disorders', 'Death-remain-Sarcopenia', 'Fractures, Bone-include-Delirium', 'Arrhythmias, Cardiac-show-Death', 'Ascites-diagnose-Lupus Erythematosus, Systemic', 'Ascites-exhibit-Ovarian Neoplasms', 'Pleural Effusion-diagnose-Lupus Erythematosus, Systemic', 'Pleural Effusion-exhibit-Ovarian Neoplasms', 'Mitochondrial Diseases-induce-Osteoporosis', 'Mitochondrial Diseases-induce-Alzheimer Disease', 'Neoplasms-affect-Taste Disorders', 'Pain Insensitivity, Congenital-enhance-Pain', 'Pain-consist-Pain Insensitivity, Congenital', 'Neoplasms-defined-Thrombosis', 'Stroke-defined-Thrombosis', 'Hemorrhage-defined-Thrombosis', 'Joint Diseases-become-Obesity', 'Osteoporosis-found-Sarcopenia', 'Chemical and Drug Induced Liver Injury-runn-Fibrosis', 'Hepatitis, Viral, Human-runn-Fibrosis', 'Death-identified-Neoplasms', 'Death-prevent-Delirium', 'Death-prevent-Anemia', 'Immunologic Deficiency Syndromes-known-Eunuchism', 'Delirium-confer-Death', 'Xerostomia-caused-Neoplasms', 'Death-compare-Aneurysm', 'Death-compare-Coronary Artery Disease', 'Death-compare-Heart Failure', 'Death-compare-Kidney Diseases', 'Death-observed-Aneurysm', 'Dementia-manage-Sleep Wake Disorders', 'Sleep Wake Disorders-experienced-Dementia', 'Critical Illness-pose-Death', 'Critical Illness-include-Respiratory Distress Syndrome', 'Critical Illness-associated-Respiratory Distress Syndrome', 'Respiratory Distress Syndrome-associated-Critical Illness', 'Critical Illness-include-Pneumonia', 'Critical Illness-associated-Pneumonia', 'Pneumonia-associated-Critical Illness', 'Inflammation-include-Critical Illness', 'Infections-lead-Critical Illness', 'Critical Illness-cause-Death', 'Diabetes Mellitus-infect-Infections', 'Hypertension-infect-Infections', 'Coronary Artery Disease-infect-Infections', 'Pulmonary Disease, Chronic Obstructive-infect-Infections', 'Cerebrovascular Disorders-infect-Infections', 'Kidney Diseases-infect-Infections', 'Vision Disorders-defined-Hearing Loss', 'Alzheimer Disease-include-Chronic Disease', 'Death-follow-Delirium', 'Eyelid Diseases-applied-Muscle Hypotonia', 'HIV Infections-occur-Gait Disorders, Neurologic', 'Cardiovascular Diseases-believed-Neoplasms', 'Alzheimer Disease-believed-Neoplasms', 'Heart Diseases-investigate-Brain Injuries', 'Pain-resolve-Nervous System Diseases', 'Delirium-followed-Embolism', 'Embolism-followed-Infections', 'Tachycardia-include-Arrhythmias, Cardiac', 'Tachycardia, Supraventricular-include-Arrhythmias, Cardiac', 'Atrioventricular Block-include-Arrhythmias, Cardiac', 'Arrhythmias, Cardiac-contribute-Death', 'Tachycardia-occur-Arrhythmias, Cardiac', 'Arrhythmias, Cardiac-include-Tachycardia, Supraventricular', 'Arrhythmias, Cardiac-include-Atrioventricular Block', 'Arrhythmias, Cardiac-occur-Atrioventricular Block', 'Arrhythmias, Cardiac-include-Tachycardia', 'Arrhythmias, Cardiac-occur-Tachycardia', 'Arrhythmias, Cardiac-include-Atrial Fibrillation', 'Arrhythmias, Cardiac-determined-Congenital, Hereditary, and Neonatal Diseases and Abnormalities', 'Arrhythmias, Cardiac-referred-Heart Diseases', 'Neurodegenerative Diseases-induced-Neoplasms', 'Pain-hypothesize-Neuralgia', 'Nervous System Diseases-begin-Headache Disorders, Secondary', 'Pain-extend-Pain Insensitivity, Congenital', 'Kidney Diseases-develop-Fever', 'Proteinuria-develop-Fever', 'Proteinuria-seen-IgA Deficiency', 'Cardiovascular Diseases-show-Sleep Wake Disorders', 'Drug-Related Side Effects and Adverse Reactions-observed-Neutropenia', 'Drug-Related Side Effects and Adverse Reactions-observed-Anemia', 'Drug-Related Side Effects and Adverse Reactions-observed-Mouth Diseases', 'Neutropenia-observed-Anemia', 'Neutropenia-observed-Acute Kidney Injury', 'Neutropenia-observed-Mouth Diseases', 'Drug-Related Side Effects and Adverse Reactions-observed-Deglutition Disorders', 'Arthritis-followed-Hypothyroidism', 'Arthritis-followed-Neoplasms', 'Arthritis-followed-Liver Diseases', 'Arthritis-followed-Kidney Diseases', 'Arthritis-followed-Osteoporosis', 'Arthritis-followed-Lung Diseases', 'Arthritis-followed-Peripheral Vascular Diseases', 'Hypoxia-gain-Chronic Disease', 'Hypoxia-gain-Nervous System Diseases', 'Nervous System Diseases-include-Chronic Disease', 'KIF1B-revert-MIR107', 'KIF1B-target-Inflammation', 'KIF1B-mediate-Neurotoxicity Syndromes', 'SIRT7-prevent-Calcinosis', 'Glucose-target-SIRT7', 'SIRT7-associated-Calcinosis', 'Calcinosis-associated-SIRT7', 'Glucose-associated-Calcinosis', 'Calcinosis-associated-Glucose', 'HOTAIR-exert-CDKN2B', 'Glucose-increase-GDF15', 'Fatty Acids-foster-Glucose', 'INS-stimulated-Glucose', 'Cardiovascular Diseases-shift-INS', 'Cardiovascular Diseases-shift-Glucose', 'TTR-disturbed-Dithiothreitol', 'TTR-disturbed-Infliximab', 'Ascorbic Acid-increase-ADIPOQ', 'Doxorubicin-induce-CDKN2A', 'Ascorbic Acid-prevent-NOS3', 'CD38-associated-Glycosaminoglycans', 'Glycosaminoglycans-associated-CD38', 'Glucose-result-CXCL10', 'MAPK8-restore-Heart Arrest', 'Hesperidin-restore-Heart Arrest', 'Hesperidin-reduce-JUN', 'Stigmasterol-inhibit-IGF1R', 'LRG1-suppress-Fatty Acids', 'Fatty Acids-regulate-ACLY', 'CHI3L1-characterized-Alzheimer Disease', 'INS-exceed-Insulin Lispro', 'Fibrosis-induced-Bleomycin', 'Infliximab-buffer-CALB1', 'CALB1-buffer-Infliximab', 'Infliximab-report-CALB1', 'LMNA-restore-rs387906871', 'rs534125149-encode-MFGE8', 'Rupture-restore-rs387906871', 'MFGE8-encode-Coronary Artery Disease', 'MAPT-increase-rs63751273', 'SLC29A1-associated-Obesity', 'Obesity-associated-SLC29A1', 'rs45573936-associated-Obesity', 'Obesity-associated-rs45573936', 'Glycogen Storage Disease Type II-genotyped-CFH', 'Glycogen Storage Disease Type II-genotyped-rs10801555', 'SIRT3-serve-Cerebral Infarction', 'YAP1-promote-Fibrosis', 'STAT3-induce-Death', 'Sleepiness-associated-APOE', 'APOE-associated-Sleepiness', 'Sleepiness-observed-APOE', 'CRP-increase-Death', 'SPHK1-result-Adenocarcinoma of Lung', 'CD38-drive-Inflammation', 'LRRN2-serve-Heart Failure', 'METRNL-play-Heart Diseases', 'SHBG-related-Obesity', 'CD4-point-Inflammation', 'TSPO-focus-Hypothalamic Neoplasms', 'Hypothalamic Neoplasms-reflect-TSPO', 'SIRT6-compare-Neoplasms', 'SIRT6-kill-Neoplasms', 'SIRT6-alleviate-Atherosclerosis', 'SIRT6-decreased-Vascular Calcification', 'SIRT6-represent-Vascular Calcification', 'SIRT6-inhibit-Calcinosis', 'SIRT6-upregulate-Calcinosis', 'Heart Arrest-play-NAGLU', 'Neoplasms-redirect-NR1I3', 'EGFR-resemble-Neoplasms', 'Alzheimer Disease-suggest-NLRP1', 'Neurotoxicity Syndromes-cause-SPP1', 'IGF1R-induce-Cardiomegaly', 'Hyperuricemia-compare-KL', 'Fractures, Bone-exclude-ALB', 'SPP1-regulate-Inflammation', 'PDCD1-increase-Glomerulonephritis', 'TTR-become-Amyloidosis', 'BACE1-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-BACE1', 'AKAP4-demonstrated-Multiple Myeloma', 'AKAP4-induced-Multiple Myeloma', 'DAO-measured-Alzheimer Disease', 'CDKN2A-investigate-Colorectal Neoplasms', 'CDKN2A-used-Colorectal Neoplasms', 'CST3-use-Renal Insufficiency, Chronic', 'KL-shown-Neoplasms', 'Hearing Loss-show-NEFL', 'TMEM106B-form-Neurodegenerative Diseases', 'TMEM106B-shed-Neurodegenerative Diseases', 'LPCAT4-prevent-Glioma', 'Diabetes Mellitus-manage-INS', 'Drug-Related Side Effects and Adverse Reactions-induce-CYP1A1', 'NOTCH2-associated-Alzheimer Disease', 'Alzheimer Disease-associated-NOTCH2', 'LONP1-contribute-Osteoarthritis', 'Acute Kidney Injury-expose-ALB', 'FOLH1-increased-Inflammation', 'Inflammation-measure-CRP', 'Cardiovascular Diseases-decrease-IL6', 'LRG1-play-Insulin Resistance', 'LRG1-increased-Obesity', 'TP53-enhance-Neurotoxicity Syndromes', 'MAPT-affected-Alzheimer Disease', 'SF3B1-occur-Myelodysplastic Syndromes', 'NR4A2-characterize-Glycogen Storage Disease Type II', 'NR4A2-involved-Glycogen Storage Disease Type II', 'MAPT-encode-Alzheimer Disease', 'Death-divided-ALB', 'MAPT-antecede-Extranodal Extension', 'DEK-associated-Inflammation', 'Inflammation-associated-DEK', 'DEK-characterize-Dementia', 'DEK-impact-Tooth, Impacted', 'TNFRSF4-test-Melanoma', 'TNFRSF4-express-Melanoma', 'Huntington Disease-impair-STAT3', 'HIV Infections-provide-CD4', 'SPARC-elevate-Obesity', 'SPARC-reduce-Inflammation', 'TRIB3-contribute-Fibrosis', 'Neoplasms-observed-TERT', 'FHL2-involved-Glucose Metabolism Disorders', 'SH2D3A-combate-Neurodegenerative Diseases', 'CRP-reported-Obesity', 'CDKN2A-mutated-Carcinoma, Squamous Cell', 'Glycogen Storage Disease Type II-treated-VEGFA', 'MAPT-occur-Dementia', 'Neoplasms-characterized-CTNNB1', 'CD38-induced-Idiopathic Pulmonary Fibrosis', 'PPP2R2C-identify-Neoplasms', 'Alzheimer Disease-stratified-CHI3L1', 'MAPT-predispose-Tauopathies', 'Neurodegenerative Diseases-related-MAPT', 'Glycogen Storage Disease Type II-used-VEGFA', 'GFAP-explain-Atrophy', 'GFAP-associated-Atrophy', 'Atrophy-associated-GFAP', 'GFAP-contribute-Memory Disorders', 'Pulmonary Disease, Chronic Obstructive-show-ARNTL', 'Williams Syndrome-associated-WRN', 'WRN-associated-Williams Syndrome', 'SMN1-affected-Muscular Atrophy, Spinal', 'SMN1-require-Muscular Atrophy, Spinal', 'MAPK15-control-Mitochondrial Diseases', 'PARP1-moving-Neoplasms', 'LMNA-lead-Progeria', 'SIRT3-suppress-Cardiomegaly', 'SIRT2-protect-Reperfusion Injury', 'SIRT6-linked-Cardiomegaly', 'Hyperinsulinism-undergo-INS', 'GJA1-associated-Cartilage Diseases', 'Cartilage Diseases-associated-GJA1', 'Pneumonia-adjusted-CRP', 'FNDC5-alleviate-Aneurysm', 'Viremia-suppress-CD4', 'ABCA1-prevent-Atherosclerosis', 'IGF1-correlated-Sarcopenia', 'Muscular Dystrophy, Duchenne-associated-INS', 'INS-associated-Muscular Dystrophy, Duchenne', 'TP53-contribute-Neoplasms', 'TP53-result-Giant Cell Tumors', 'HMBS-cause-Porphyrias', 'BANF1-bind-Rupture', 'HMBS-involved-Carcinoma, Hepatocellular', 'NEFL-remain-Death', 'SIRT1-prevent-Obesity', 'SIRT1-restore-Obesity', 'HIF1A-activated-Myalgia', 'Alzheimer Disease-cleave-MAPT', 'SIRT7-lead-Neoplasms', 'Fractures, Bone-accompanied-HDAC2', 'CHI3L1-prevent-Osteoporosis', 'CHI3L1-decrease-Osteoporosis', 'TOMM40-associated-Mitochondrial Diseases', 'Mitochondrial Diseases-associated-TOMM40', 'SLC29A3-listed-Histiocytosis', 'SLC29A1-cause-Calcinosis', 'FOXO1-related-Myelodysplastic Syndromes', 'FOXO1-associated-Myelodysplastic Syndromes', 'Myelodysplastic Syndromes-associated-FOXO1', 'TTR-include-Amyloidosis', 'TTR-treat-Amyloidosis', 'CRP-suggest-Shock, Septic', 'Meningitis, Bacterial-focus-CRP', 'ANGPT2-link-Death', 'Pulpitis-show-CAT', 'Ischemia-overexpress-MIR29A', 'MIR21-associated-Hypertrophy', 'Hypertrophy-associated-MIR21', 'PRAL-associated-Hip Fractures', 'Hip Fractures-associated-PRAL', 'Atrial Fibrillation-trigger-Glucose', 'Atrial Fibrillation-trigger-Fatty Acids', 'Triglycerides-improve-Glucose', 'Glucose-identify-Death', 'Cholesterol-identify-Death', 'Infliximab-triggered-Glucose', 'Hyperglycemia-show-Glucose', 'Blood Glucose-taken-Central Nervous System Diseases', 'Neoplasms-interrogate-Glycogen', 'Doxorubicin-affect-Cardiomyopathies', 'Hesperidin-attenuate-Heart Arrest', 'Anthracyclines-associated-Cardiotoxicity', 'Cardiotoxicity-associated-Anthracyclines', 'Alzheimer Disease-consist-Oligosaccharides', 'Anthracyclines-used-Drug-Related Side Effects and Adverse Reactions', 'Ascorbic Acid-contribute-Intervertebral Disc Degeneration', 'Enoxaparin-associated-Death', 'Death-associated-Enoxaparin', 'Diabetes Mellitus-induced-Streptozocin', 'Glucose-found-Diabetes Mellitus', 'Plaque, Amyloid-compare-Glycogen', 'Plaque, Amyloid-possess-Glycogen', 'Cholesterol-stabilize-Atherosclerosis', 'Cholesterol-elevated-Alzheimer Disease', 'Triglycerides-consider-Alzheimer Disease', 'Triglycerides-correlate-Dementia', 'Triglycerides-correlate-Alzheimer Disease', 'Withanolides-mediate-Seizures', 'Cholesterol-offer-Alzheimer Disease', 'Calcitriol-overcome-Infections', 'Fatty Acids-ameliorate-Cardiovascular Diseases', 'Phosphatidylcholines-reduce-Memory Disorders', 'Eicosanoids-work-Memory Disorders', 'Dinoprostone-associated-Chronic Periodontitis', 'Chronic Periodontitis-associated-Dinoprostone', 'Atorvastatin-modulate-Hyperlipoproteinemia Type II', 'Triglycerides-associated-Muscular Dystrophy, Duchenne', 'Muscular Dystrophy, Duchenne-associated-Triglycerides', 'Inflammation-stimulate-Endocannabinoids', 'Dyslipidemias-defined-Cholesterol', 'Glycogen Storage Disease Type II-observe-Fatty Acids', 'Dinoprostone-enhance-Infections', 'Angiotensins-associated-Death', 'Death-associated-Angiotensins', 'Death-increase-Infliximab', 'Prostaglandins E-associated-Obesity, Abdominal', 'Obesity, Abdominal-associated-Prostaglandins E', 'Obesity-associated-rs9939609', 'rs9939609-associated-Obesity', 'TNXB-exert-SKIV2L', 'FKBPL-exert-SKIV2L', 'rs12153855-exert-SKIV2L', 'rs9391734-exert-SKIV2L', 'FGF23-include-PTH', 'FGF23-include-Calcitriol', 'FGF23-include-Inflammation', 'ULK1-reduced-Osteoarthritis', 'MAP1LC3A-reduced-Osteoarthritis', 'FERMT2-show-Malocclusion, Angle Class II', 'Sleep Wake Disorders-apply-CRP', 'CFH-associated-Vision Disorders', 'Vision Disorders-associated-CFH', 'CFI-associated-Vision Disorders', 'Vision Disorders-associated-CFI', 'BECN1-enhanced-Neoplasms', 'TET2-activate-HIF1A', 'ASXL1-activate-HIF1A', 'RUNX1-activate-HIF1A', 'KMT2A-activate-HIF1A', 'ADARB2-related-Atherosclerosis', 'CDKN2A-comprise-CDKN2B', 'CDKN2A-encode-Neoplasms', 'WRN-increase rate in-PCNA', 'WRN-increase-PCNA', 'CFAP97-associated-INS', 'INS-associated-CFAP97', 'S100A8-exacerbate-Osteoarthritis', 'MMP1-exacerbate-Osteoarthritis', 'Cholesterol-associated-Triglycerides', 'Triglycerides-associated-Cholesterol', 'ADIPOQ-associated-Triglycerides', 'Triglycerides-associated-ADIPOQ', 'CFAP97-associated-Triglycerides', 'Triglycerides-associated-CFAP97', 'Cholesterol-associated-INS', 'INS-associated-Cholesterol', 'Acquired Immunodeficiency Syndrome-associated-CD4', 'CD4-associated-Acquired Immunodeficiency Syndrome', 'SMURF2-result-SP7', 'SMURF2-result-RUNX2', 'APOE-involved-Cholesterol', 'ABCA1-involved-Cholesterol', 'rs4986790-show-APOE', 'FOXO3-correlate-SKP2', 'FOXO3-related-SKP2', 'rs4986790-show-Cholesterol', 'FOXO3-correlate-Neoplasms', 'SKP2-correlate-Neoplasms', 'FOXO3-investigate-Carcinoma, Hepatocellular', 'SKP2-investigate-Carcinoma, Hepatocellular', 'FOXO3-considered-Carcinoma, Hepatocellular', 'SKP2-considered-Carcinoma, Hepatocellular', 'Inflammation-measure-IL6', 'RECQL-related-Neoplasms', 'RECQL-related-Rothmund-Thomson Syndrome', 'WRN-related-Neoplasms', 'WRN-related-Rothmund-Thomson Syndrome', 'RECQL4-related-Neoplasms', 'RECQL4-related-Rothmund-Thomson Syndrome', 'KL-examine-TNFSF10', 'Death-induce-Neoplasms', 'TNFSF10-induce-Neoplasms', 'KL-examine-Death', 'LMNA-identified-Lipodystrophy', 'FOXP1-decreased-CCND1', 'E2F1-decreased-CCND1', 'FOXP1-induce-Heart Arrest', 'Heart Arrest-induce-E2F1', 'Heart Arrest-decreased-CCND1', 'Disease Progression-observed-GABRA2', 'DES-contribute-Mitochondrial Diseases', 'Disease Progression-observed-HOXA1', 'MYOT-contribute-Mitochondrial Diseases', 'Disease Progression-observed-NEUROD1', 'Disease Progression-observed-NEUROD2', 'Disease Progression-observed-PGR', 'Disease Progression-observed-STK11', 'Disease Progression-observed-SYK', 'MAPT-result-Alzheimer Disease', 'NAGLU-show-RBP4', 'NAGLU-show correlation significant Among-Fanconi Syndrome', 'Fanconi Syndrome-show-RBP4', 'NAGLU-detect-Fanconi Syndrome', 'RBP4-detect-Fanconi Syndrome', 'TAT-induce-MAPT', 'MAPT-induce-Alzheimer Disease', 'CDX2-associated-Death', 'Death-associated-CDX2', 'QRSL1-associated-Death', 'Death-associated-QRSL1', 'Renal Insufficiency, Chronic-of composition be-Hemolytic-Uremic Syndrome', 'TRPC6-investigate-TRPC1', 'TRPC6-investigate-Carcinoma, Hepatocellular', 'TRPC6-associated-Carcinoma, Hepatocellular', 'Carcinoma, Hepatocellular-associated-TRPC6', 'Anemia-investigate-EPO', 'KL-associated-Pituitary Neoplasms', 'Pituitary Neoplasms-associated-KL', 'IL6-made-Inflammation', 'SIRT1-downregulated-Neoplasms', 'SIRT2-downregulated-Neoplasms', 'SIRT3-downregulated-Neoplasms', 'SIRT5-downregulated-Neoplasms', 'SIRT6-downregulated-Neoplasms', 'SIRT7-downregulated-Neoplasms', 'ECM1-discuss-Heart Arrest', 'ADCY4-protect-KL', 'Heart Failure-protect-Mitochondrial Diseases', 'Delirium-include-CRP', 'ADCY4-protect-Heart Failure', 'ADCY4-protect-Mitochondrial Diseases', 'Delirium-include-AZGP1', 'IL6-include-Delirium', 'IL2-include-Delirium', 'CXCL9-increase in-Chagas Disease', 'CXCL10-increase in-Chagas Disease', 'KL-protect-Mitochondrial Diseases', 'ALB-measured-GPT', 'Pulmonary Disease, Chronic Obstructive-detected-USP7', 'Pulmonary Disease, Chronic Obstructive-detected-EP300', 'ALB-measured-Triglycerides', 'ALB-measured-Hypoglycemia', 'GJA1-linked-MAPK8', 'GJA1-linked-Basal Ganglia Diseases', 'TAT-reduce-Death', 'GALC-encode-GLB1', 'TAT-reduce mortality in-Infections', 'BECN1-reduce-Death', 'BECN1-reduce mortality in-Infections', 'Progeria-show-NLRP3', 'Progeria-show-CASP1', 'Parkinson Disease-linked-Mitochondrial Diseases', 'Parkinson Disease-linked-PARK7', 'PARK7-linked-Mitochondrial Diseases', 'Parkinson Disease-linked-PINK1', 'PINK1-linked-Mitochondrial Diseases', 'Neurotoxicity Syndromes-induced-Alzheimer Disease', 'Neurotoxicity Syndromes-attenuate-Alzheimer Disease', 'Neurotoxicity Syndromes-induced-TNFAIP1', 'Neurotoxicity Syndromes-target-TNFAIP1', 'TNFAIP1-attenuate-Alzheimer Disease', 'TOMM40-be in-APOE', 'TOMM40-influence-Alzheimer Disease', 'TP53-controlled-MDM2', 'Neoplasms-controlled-MDM2', 'FGF21-inhibit-TP53', 'FGF21-protect in-PRKAA2', 'FGF21-highlight-Neurodegenerative Diseases', 'TP53-inhibit-Stroke', 'TP53-inhibit-Neurodegenerative Diseases', 'Progeria-be with-ZMPSTE24', 'MDK-use-CST3', 'Death-related-Renal Insufficiency, Chronic', 'MDK-use-Renal Insufficiency, Chronic', 'CXCL8-upregulated-Infections', 'TP53-occur at-CDKN1A', 'CXCL10-upregulated-Infections', 'Infections-found-TNF', 'EEF1E1-repressed-Hypoxia', 'Infections-found-CXCL8', 'Infections-found-CXCL10', 'Hypoxia-repressed-CDKN2A', 'LEP-play-Arthritis', 'RETN-play-Arthritis', 'GRN-investigate-Alzheimer Disease', 'ADIPOQ-play-Arthritis', 'PSAP-investigate-Alzheimer Disease', 'NAMPT-play-Arthritis', 'Neoplasms-be with-TET2', 'Neoplasms-occur-TET2', 'Neoplasms-occur-SRSF2', 'KL-inhibit-WNT1', 'KL-inhibit-Mitochondrial Diseases', 'MGP-linked-BGLAP', 'KL-inhibit-Blister', 'ACAT2-suggest-Cholesterol Esters', 'Hashimoto Disease-show-Thyroiditis, Autoimmune', 'Thyroiditis, Autoimmune-show-CD4', 'Hashimoto Disease-show-CD4', 'Thyroiditis, Autoimmune-show-CD8A', 'Hashimoto Disease-show-CD8A', 'Neoplasms-regulate-NFKB1', 'SMAD4-mediated-PRKAA2', 'Diabetes Mellitus-mediated-PRKAA2', 'Nervous System Diseases-mediated-PRKAA2', 'Kidney Diseases-mediated-PRKAA2', 'IL6-show-Cardiovascular Diseases', 'TNF-show-Cardiovascular Diseases', 'IL10-show-Cardiovascular Diseases', 'Neoplasms-up-regulated-EGF', 'TGFA-induce-Osteosarcoma', 'EGF-play-Neoplasms', 'LOX-include-MIR30A', 'AVEN-include-MIR30A', 'DLL1-observed-NOS3', 'DLL1-express-Neoplasms', 'VWF-stained-NOS3', 'Cockayne Syndrome-give-ERCC8', 'Cockayne Syndrome-give-ERCC6', 'Cockayne Syndrome-give-ERCC3', 'Cockayne Syndrome-give-ERCC4', 'Cockayne Syndrome-give-ERCC1', 'Alzheimer Disease-evaluate-MAPT', 'Alzheimer Disease-evaluate-VEGFA', 'VEGFA-evaluate-Alzheimer Disease', 'NOS3-associated-Hearing Loss, Central', 'Hearing Loss, Central-associated-NOS3', 'CAV1-associated-Hearing Loss, Central', 'Hearing Loss, Central-associated-CAV1', 'VEGFA-interact with-MAPT', 'IGF1-focuss-AKT1', 'VEGFA-predict-Ossification of Posterior Longitudinal Ligament', 'AKT1-focuss-MTOR', 'MAPT-predict-Ossification of Posterior Longitudinal Ligament', 'Sarcopenia-focuss-AKT1', 'TFAM-reverse-Mitochondrial Diseases', 'Hyperlipidemias-associated-Coronary Artery Disease', 'Coronary Artery Disease-associated-Hyperlipidemias', 'INS-of Assessment be-Glucose', 'Hypothalamic Neoplasms-distinguished-GH1', 'DNMT3A-targeted-LOXL1', 'DNMT3A-restore-Drug-Related Side Effects and Adverse Reactions', 'LOXL1-restore-Drug-Related Side Effects and Adverse Reactions', 'APOE-include-Alzheimer Disease', 'Seizures-fit-INS', 'Seizures-fit-GH1', 'MAPT-serve-MSRB2', 'MAPT-serve-Alzheimer Disease', 'MSRB2-serve-Alzheimer Disease', 'Acromegaly-characterized-GGH', 'Acromegaly-characterized-IGF1', 'MAPT-attenuate-CASP1', 'MAPT-in hyperphosphorylation be-SYP', 'Cockayne Syndrome-regulate-ERCC8', 'rs9536314-associated-BRCA1', 'BRCA1-associated-rs9536314', 'rs9536314-associated-BRCA2', 'BRCA2-associated-rs9536314', 'Neoplasms-be in-BRCA1', 'rs9536314-associated-Neoplasms', 'Neoplasms-associated-rs9536314', 'rs1043618-be in-HSPA1A', 'FOXO3-antagonize-CDKN2A', 'CDKN2A-antagonize-ETS2', 'Huntington Disease-transcriptional targets of-FOXO3', 'Huntington Disease-reprogram-FOXO3', 'Huntington Disease-antagonize-CDKN2A', 'Huntington Disease-reprogram-ETS2', 'Heart Diseases-accompany-Inflammation', 'PINK1-increased-Alzheimer Disease', 'ALB-markers of-Malnutrition', 'WRN-associate-PCNA', 'PCNA-associate-WRN', 'WRN-associate-Werner Syndrome', 'Werner Syndrome-associate-WRN', 'Cardiac Output, Low-observe-RUNX2', 'Cardiac Output, Low-observe-ALPP', 'HBEGF-include-Prostatic Neoplasms', 'HOXC13-include-Prostatic Neoplasms', 'IGFBP2-include-Prostatic Neoplasms', 'SATB1-include-Prostatic Neoplasms', 'Alzheimer Disease-be in-APOE', 'Lymphoma, Large-Cell, Anaplastic-known-Astrocytoma', 'NPM1-known-Lymphoma, Large-Cell, Anaplastic', 'Lymphoma, Large-Cell, Anaplastic-known-JAK2', 'Lymphoma, Large-Cell, Anaplastic-known-STAT5A', 'STAT5B-be independent prognostic marker of-Astrocytoma', 'INS-contribute-NGF', 'INS-contribute-Urinary Bladder, Overactive', 'DLG4-investigated-Alzheimer Disease', 'DLG3-investigated-Alzheimer Disease', 'PAK1-known-Neoplasms', 'PAK1-known-Alzheimer Disease', 'PAK1-known-Acquired Immunodeficiency Syndrome', 'PAK1-known-Bacterial Infections', 'PAK1-known-Inflammation', 'PAK1-known-Asthma', 'PAK1-known-Arthritis', 'PAK1-known-Diabetes Mellitus', 'PAK1-known-Tuberous Sclerosis', 'PAK1-known-Epilepsy', 'PAK1-known-Learning Disabilities', 'CRP-determined-KL', 'Glucose-determined-KL', 'Genetic Diseases, Inborn-associated-ARMS2', 'ARMS2-associated-Genetic Diseases, Inborn', 'Vision Disorders-associated-ARMS2', 'ARMS2-associated-Vision Disorders', 'Genetic Diseases, Inborn-associated-HTRA1', 'HTRA1-associated-Genetic Diseases, Inborn', 'Vision Disorders-associated-HTRA1', 'HTRA1-associated-Vision Disorders', 'Infections-promote-NFKBIA', 'CXCL8-enhance-Infections', 'Infections-induce-CCL5', 'MAPT-suggested-Alzheimer Disease', 'DIRAS3-activation of-AKT1', 'DIRAS3-induce-AKT1', 'DIRAS3-activation of-MTOR', 'DIRAS3-induce-MTOR', 'DIRAS3-induce-Heart Arrest', 'Ghrelin-increased-INS', 'Ghrelin-increased-GCG', 'Ghrelin-increased-CCK', 'Ghrelin-increased-GIP', 'Ghrelin-increased-Glucose', 'NFE2L2-associate with-CDKN2A', 'NFE2L2-remain-CDKN2A', 'NFE2L2-associate-Diabetes Mellitus', 'Diabetes Mellitus-associate-NFE2L2', 'CDKN2A-associate-Diabetes Mellitus', 'Diabetes Mellitus-associate-CDKN2A', 'Renal Insufficiency, Chronic-show-FGF23', 'Renal Insufficiency, Chronic-show-PTH', 'Chemical and Drug Induced Liver Injury-observed-rs769217', 'NOX4-induce-HSP90AA1', 'NOS3-dissociate-HSP90AA1', 'Breast Neoplasms-evaluated-EREG', 'Breast Neoplasms-evaluated-PGR', 'Breast Neoplasms-evaluated-CTSD', 'Anthracyclines-account-ABCB1', 'Anthracyclines-account-C19orf48', 'Anthracyclines-account-MVP', 'CD200R1-correlate with-Parkinson Disease', 'Heart Arrest-inhibit-POLD3', 'Heart Arrest-inhibit-TP53', 'Heart Arrest-reduce-CDKN2A', 'LEP-shown-Osteoarthritis', 'LEP-shown-Osteoporosis', 'TNFRSF11B-shown-Osteoarthritis', 'Osteoporosis-shown-TNFRSF11B', 'PPARG-regulate-Alzheimer Disease', 'YY1-regulate-Alzheimer Disease', 'SREBF2-regulate-Alzheimer Disease', 'EGR1-identified-Alzheimer Disease', 'EGR1-regulate-Alzheimer Disease', 'Eye Infections-associated-Retinal Degeneration', 'Retinal Degeneration-associated-Eye Infections', 'Inflammation-associated-Retinal Degeneration', 'Retinal Degeneration-associated-Inflammation', 'IDO1-influence-Eye Infections', 'IDO1-associated-Retinal Degeneration', 'Retinal Degeneration-associated-IDO1', 'BAMBI-associated-Retinal Degeneration', 'Retinal Degeneration-associated-BAMBI', 'Inflammation-support-Asthma', 'Infections-include-IDO1', 'Infections-regulated-IDO1', 'Infections-include-BAMBI', 'Infections-regulated-BAMBI', 'Infections-include-ATF3', 'Infections-regulated-ATF3', 'Infections-include-TNFRSF10D', 'Infections-regulated-TNFRSF10D', 'Inflammation-assessed-IL6', 'Inflammation-derived-IL6', 'GHRH-reflect-GGH', 'Movement Disorders-be in-Hypothalamic Neoplasms', 'Movement Disorders-reflect-GHRH', 'Hyperkinesis-reflect-GHRH', 'GHRH-be in-Hypothalamic Neoplasms', 'GHRH-reflect-Hypothalamic Neoplasms', 'Movement Disorders-reflect-GGH', 'Hyperkinesis-reflect-GGH', 'GGH-be in-Hypothalamic Neoplasms', 'GGH-reflect-Hypothalamic Neoplasms', 'Atherosclerosis-associated-REN', 'REN-associated-Atherosclerosis', 'Diabetes Mellitus-associated-REN', 'REN-associated-Diabetes Mellitus', 'Renal Insufficiency, Chronic-associated-REN', 'REN-associated-Renal Insufficiency, Chronic', 'NFE2L2-induce-HMOX1', 'Atherosclerosis-associated-NFE2L2', 'NFE2L2-associated-Atherosclerosis', 'NFE2L2-enhance-Glutathione', 'Diabetes Mellitus-associated-NFE2L2', 'NFE2L2-associated-Diabetes Mellitus', 'HMOX1-enhance-Glutathione', 'Renal Insufficiency, Chronic-associated-NFE2L2', 'NFE2L2-associated-Renal Insufficiency, Chronic', 'KL-activate-NFE2L2', 'KL-protect-Neurologic Manifestations', 'NFE2L2-protect-Neurologic Manifestations', 'SMURF2-elevated-TP53', 'PINK1-remove-RHOT1', 'RHOT1-clear-LRRK2', 'LRRK2-remove-RHOT1', 'RHOT1-clear-PINK1', 'RHOT1-clear-Parkinson Disease', 'Parkinson Disease-remove-RHOT1', 'NPC1-affect-Sphingolipids', 'NPC2-affect-Sphingolipids', 'NPC2-affect-Sterols', 'LEP-secrete-CCL5', 'ADIPOQ-secrete-CCL5', 'Neurodegenerative Diseases-result-NPC1', 'Neurodegenerative Diseases-result-NPC2', 'Neurodegenerative Diseases-result-Sphingolipids', 'Neurodegenerative Diseases-affect-Sphingolipids', 'Neurodegenerative Diseases-result-Sterols', 'Neurodegenerative Diseases-affect-Sterols', 'LEP-secrete-Glutathione', 'CCL5-increased-Pulmonary Disease, Chronic Obstructive', 'ADIPOQ-secrete-Glutathione', 'CCL5-secrete-Glutathione', 'TRIB3-play-AKT1', 'AKT1-play-Osteoarthritis', 'TRIB3-play-Osteoarthritis', 'TP53-be target by-SIRT1', 'Hypoglycemia-reduce-Hyperglycemia', 'Osteoarthritis-decrease-FOXO4', 'Osteoarthritis-demonstrate-FOXO4', 'SYP-known-SV2A', 'SV2A-known-SLC17A7', 'Osteoarthritis-decrease-PSMD11', 'Osteoarthritis-demonstrate-PSMD11', 'DPP4-reduce-Hyperglycemia', 'Acarbose-reduce-Hyperglycemia', 'TPP2-exhibit-MTOR', 'SV2A-known-Dementia', 'VEGFA-found-CDH1', 'VEGFA-found-Neoplasms', 'TPP2-affect-Glucose', 'SIRT6-affect-Glucose', 'HFE-appear-APOE', 'Pancreatitis-reduce-Hyperglycemia', 'PSMD11-increase levels of-ACAN', 'HFE-appear-Leukoencephalopathies', 'CRP-appear-Venous Thromboembolism', 'Glucose-stimulate-INS', 'F8-appear-Venous Thromboembolism', 'Glucose-stimulate-GCG', 'Pancreatitis-inhibit-INS', 'Pancreatitis-inhibit-GCG', 'GCG-reduce-Hyperglycemia', 'Obesity-improve-Glucose Intolerance', 'Obesity-improve-CDKN2A', 'Obesity-improve-INS', 'NHP2-lead-TERC', 'TERC-lead-GAR1', 'GAR1-different impact on-TERC', 'rs7759938-be in-LIN28B', 'rs16991615-be in-MCM8', 'rs2947411-be in-TMEM18', 'Cardiovascular Diseases-associated-VWF', 'VWF-associated-Cardiovascular Diseases', 'EPO-review-Neoplasms', 'EPO-review-Anemia', 'EPOR-make-Neoplasms', 'EPOR-make-Anemia', 'WRN-exhibit-KAT2B', 'WRN-immortalize-KAT2B', 'ERBB2-granted-Breast Neoplasms', 'ERBB4-granted-Breast Neoplasms', 'Amnesia-immortalize-Werner Syndrome', 'WRN-transactivate-Amnesia', 'CXCR2-altered-Alzheimer Disease', 'WRN-immortalize-Amnesia', 'WRN-diminish-Amnesia', 'Werner Syndrome-exhibit-KAT2B', 'Werner Syndrome-immortalize-KAT2B', 'LCN2-include-Colorectal Neoplasms', 'DUOX2-include-Colorectal Neoplasms', 'DNMT1-suppress-CDKN2A', 'Werner Syndrome-maintain-Heart Arrest', 'Werner Syndrome-maintain-CDKN2A', 'KIT-approved-Gastrointestinal Stromal Tumors', 'Heart Arrest-base-CDKN2A', 'Heart Arrest-maintain-CDKN2A', 'FLT3-approved-Gastrointestinal Stromal Tumors', 'Werner Syndrome-maintain-TP53', 'Heart Arrest-base-TP53', 'Heart Arrest-maintain-TP53', 'BAG5-bind alpha synuclein in-Parkinson Disease', 'INSR-associated-Dementia', 'Dementia-associated-INSR', 'INSR-associated-Neurodegenerative Diseases', 'Neurodegenerative Diseases-associated-INSR', 'INSR-associated-Alzheimer Disease', 'Alzheimer Disease-associated-INSR', 'INS-associated-Neurodegenerative Diseases', 'Neurodegenerative Diseases-associated-INS', 'Atherosclerosis-predict-Coronary Artery Disease', 'CRP-predict-Coronary Artery Disease', 'Neoplasms-be with-Pancreatic Neoplasms', 'Neoplasms-include-Pancreatic Neoplasms', 'BECN1-upregulate-Neoplasms', 'Prostatitis-compromise-RB1CC1', 'Neoplasms-upregulate-RB1CC1', 'Pancreatic Neoplasms-compromise-RB1CC1', 'SST-regulate metabolism through-MME', 'SST-catalyzed-MME', 'SST-metabolism of-Alzheimer Disease', 'SST-regulate-Alzheimer Disease', 'Alzheimer Disease-catalyzed-MME', 'KL-play-Diabetes Mellitus', 'SIRT1-play-Diabetes Mellitus', 'Diabetes Mellitus, Type 2-mediate-Inflammation', 'Glucose-correlate with-VWF', 'Inflammation-implicate-IRS1', 'Glucose-correlate-TFPI', 'Inflammation-implicate-MAPK8', 'Inflammation-implicate-EIF2AK2', 'Doxorubicin-evaluate-CAT', 'Doxorubicin-evaluate-GSR', 'Doxorubicin-evaluate-Lipid Peroxides', 'Doxorubicin-evaluate-Glutathione', 'Doxorubicin-evaluate-Breast Neoplasms', 'Cystic Fibrosis-result-Hepatolenticular Degeneration', 'Cystic Fibrosis-result-ATP7B', 'GHRH-synthesis of-GGH', 'GHRH-stimulate-GGH', 'Ghrelin-co-localize-GHRH', 'GGH-show-KL', 'ACAN-display-Osteoarthritis', 'SOX9-display-Osteoarthritis', 'ARNTL-associated-NPAS2', 'NPAS2-associated-ARNTL', 'ARNTL-associated-rs3816358', 'rs3816358-associated-ARNTL', 'ARNTL-associated-rs3768984', 'rs3768984-associated-ARNTL', 'NPAS2-associated-rs3816358', 'rs3816358-associated-NPAS2', 'NPAS2-associated-rs3768984', 'rs3768984-associated-NPAS2', 'rs1047776-associated-rs2238114', 'rs2238114-associated-rs1047776', 'rs1047776-associated-LRRC23', 'LRRC23-associated-rs1047776', 'rs2238114-associated-LRRC23', 'LRRC23-associated-rs2238114', 'Hemolysis-quantified-HP', 'Niemann-Pick Disease, Type C-lead-NPC1', 'Hemolysis-quantified-HPX', 'Neurodegenerative Diseases-lead-NPC1', 'Niemann-Pick Disease, Type C-lead-NPC2', 'Neurodegenerative Diseases-lead-NPC2', 'Niemann-Pick Disease, Type C-lead-Cholesterol', 'Neurodegenerative Diseases-lead-Cholesterol', 'Niemann-Pick Disease, Type C-lead-Sphingolipids', 'Neurodegenerative Diseases-lead-Sphingolipids', 'Alzheimer Disease-related-PSEN1', 'POMC-decreased-INS', 'POMC-decreased-Diabetes Mellitus', 'INS-decreased-Diabetes Mellitus', 'NRF1-lead-Mitochondrial Diseases', 'Alzheimer Disease-cause-MAPT', 'Alzheimer Disease-lead-MAPT', 'INS-associated-TLR4', 'TLR4-associated-INS', 'Sarcopenia-associated-Endotoxemia', 'Endotoxemia-associated-Sarcopenia', 'INS-associated-Endotoxemia', 'Endotoxemia-associated-INS', 'Sarcopenia-associated-TLR4', 'TLR4-associated-Sarcopenia', 'SMARCA4-mitigate-PINK1', 'Kidney Diseases, Cystic-include-Chemical and Drug Induced Liver Injury', 'Kidney Diseases-include-Chemical and Drug Induced Liver Injury', 'PKD1-include-Chemical and Drug Induced Liver Injury', 'PKD2-include-Chemical and Drug Induced Liver Injury', 'GHRH-peak-Stroke', 'VEGFA-enhance-Salivary Gland Diseases', 'FGF9-enhance-Salivary Gland Diseases', 'CD4-alter-IL21', 'Infections-alter-Inflammation', 'Infections-alter-CD4', 'Infections-trigger-CD4', 'Basal Ganglia Diseases-include-Alzheimer Disease', 'NRGN-include-Alzheimer Disease', 'TRPV1-target-TRPM3', 'TRPA1-target-TRPM3', 'TRPV1-include-Pain', 'ANGPTL2-associated-CRP', 'CRP-associated-ANGPTL2', 'ANGPTL2-associated-Triglycerides', 'Triglycerides-associated-ANGPTL2', 'TRPA1-include-Pain', 'Pain-include-TRPM3', 'Pain-target-TRPM3', 'SIRT1-include-EREG', 'Inflammation-include-Kidney Diseases', 'SH2B3-associated-ATXN2', 'ATXN2-associated-SH2B3', 'Inflammation-include-EREG', 'SH2B3-associated-BRAP', 'BRAP-associated-SH2B3', 'Kidney Diseases-include-SIRT1', 'CD4-contribute-HIV Infections', 'PSENEN-intersect-ATP6AP1', 'CCR5-contribute-HIV Infections', 'CXCR4-contribute-HIV Infections', 'Lung Neoplasms-linked-Death', 'PSENEN-intersect-PRKAB1', 'SIRT6-impair-Nervous System Diseases', 'SH2B3-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-SH2B3', 'SH2B3-associated-Lung Neoplasms', 'Lung Neoplasms-associated-SH2B3', 'SH2B3-associated-Death', 'Death-associated-SH2B3', 'SH2B3-linked-Death', 'Glucose-suppressed-INS', 'Glucose-suppressed-GCG', 'Glucose-be higher during-INS', 'rs3184504-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-rs3184504', 'rs3184504-associated-Lung Neoplasms', 'Lung Neoplasms-associated-rs3184504', 'rs3184504-linked-Death', 'HOPX-implicated-Endometrial Neoplasms', 'PCNA-implicated-Endometrial Neoplasms', 'HSF2-trigger-HSF1', 'HSF2-trigger-Neoplasms', 'Neoplasms-trigger-HSF1', 'HSF2-interact-HSF1', 'HSF2-participate-Neoplasms', 'HSF1-participate-Neoplasms', 'ALB-observed-Hypersplenism', 'SRC-decrease-BAX', 'PCNA-decrease-BAX', 'CCND1-increase-BAX', 'APOE-carry-TREM2', 'APOE-observed-Alzheimer Disease', 'Alzheimer Disease-carry-TREM2', 'Lewy Body Disease-associated-TMEM106B', 'TMEM106B-associated-Lewy Body Disease', 'Lewy Body Disease-associated-GRN', 'GRN-associated-Lewy Body Disease', 'Lewy Body Disease-associated-rs1990622', 'rs1990622-associated-Lewy Body Disease', 'Lewy Body Disease-associated-rs5848', 'rs5848-associated-Lewy Body Disease', 'COL3A1-decrease-Glucose', 'BCL2-prevent-Neoplasms', 'TCL1A-prevent-Neoplasms', 'Glucose-downregulate-COL1A1', 'Glucose-downregulate-COL3A1', 'MEST-found-Infertility, Female', 'TP53-inactivated-G6PD', 'Neoplasms-inactivated-TP53', 'Infertility, Male-associated-IGF2', 'IGF2-associated-Infertility, Male', 'Infertility, Male-associated-MEST', 'MEST-associated-Infertility, Male', 'INS-be in-Hypertension', 'Neoplasms-contain-EREG', 'Neoplasms-contain-PGR', 'ACE-assess-Glucose', 'INS-assess-Glucose', 'ACE-be in-Hypertension', 'Hypertension-assess-Glucose', 'Neoplasms-compared-EREG', 'Neoplasms-compared-PGR', 'TNFSF12-promote-Atherosclerosis', 'TNFSF12-decrease-ACTA2', 'TNFRSF12A-promote-Atherosclerosis', 'TNFSF12-increase-MYH11', 'TNFSF12-increase-BMP2', 'TNFSF12-increase-MMP9', 'TNFRSF12A-decrease-ACTA2', 'Necrosis-measure-Lipopolysaccharides', 'TNFRSF12A-increase-MYH11', 'TNFRSF12A-increase-BMP2', 'TNFRSF12A-increase-MMP9', 'ACTA2-increase-BMP2', 'ACTA2-increase-MMP9', 'MYH11-increase-BMP2', 'MYH11-increase-MMP9', 'BMP2-increase-MMP9', 'TNFSF12-promote-Calcinosis', 'TNFRSF12A-promote-Calcinosis', 'Calcinosis-decrease-ACTA2', 'Calcinosis-decrease-MYH11', 'Calcinosis-increase-BMP2', 'Calcinosis-increase-MMP9', 'TNFSF12-favor-Calcinosis', 'TNFRSF12A-favor-Calcinosis', 'TLR4-combined-HSP90AA1', 'Leukemia, Myeloid, Acute-combined-HSP90AA1', 'DNMT1-detected-Neoplasms', 'MSTN-be in-Sarcopenia', 'Neoplasms-promote-FASLG', 'Neoplasms-promote-BCL2L11', 'GCG-include-Diabetes Mellitus', 'Inflammation-inhibit-SIRT3', 'Fibrosis-inhibit-SIRT3', 'Inflammation-evaluated-CRP', 'Inflammation-include-ALB', 'Inflammation-evaluated-ALB', 'Abnormalities, Drug-Induced-increased-PRL', 'Sick Sinus Syndrome-shown-CACNA1C', 'Sick Sinus Syndrome-shown-CACNA1D', 'Stomach Neoplasms-be with-BUB1B', 'BUB1B-evaluated-Stomach Neoplasms', 'NOS3-evaluated-Stomach Neoplasms', 'Glucose Metabolism Disorders-controlled-INS', 'NFE2L2-evidenced-Erectile Dysfunction', 'Glucose Metabolism Disorders-controlled-INSR', 'CACNA1C-confirm-MIR1976', 'CACNA1D-confirm-MIR1976', 'TNFSF11-trigger-POSTN', 'TNFSF11-trigger-CTSK', 'POSTN-trigger-CTSK', 'TNFSF11-induce-Bone Neoplasms', 'Bone Neoplasms-trigger-POSTN', 'Bone Neoplasms-trigger-CTSK', 'TMPRSS2-facilitate-Arbovirus Infections', 'TMPRSS4-facilitate-Arbovirus Infections', 'DPP4-facilitate-Arbovirus Infections', 'IDH1-through-NPM1', 'IDH1-be in-Leukemia, Myeloid, Acute', 'Leukemia, Myeloid, Acute-through-NPM1', 'Death-predict-CRP', 'Werner Syndrome-prevent-Carcinogenesis', 'WRN-prevent-Carcinogenesis', 'ANKS1B-involved-Alzheimer Disease', 'Alzheimer Disease-propose-ADAMTS3', 'Alzheimer Disease-propose-PPFIA1', 'FABP2-correlated-MMP1', 'Lymphoma-be with-MYC', 'IL2-considered-Infliximab', 'Alzheimer Disease-include-BACE1', 'Alzheimer Disease-involved-BACE1', 'Alzheimer Disease-include-MAPT', 'Alzheimer Disease-involved-MAPT', 'CISD2-regulate-Neoplasms', 'CISD2-regulate-TXNIP', 'CISD2-regulate-Neurodegenerative Diseases', 'CISD2-result-TXNIP', 'CISD2-result in-Neoplasms', 'SIRT1-induced-PML', 'SIRT1-induced-Neoplasms', 'Kidney Diseases-participate-Glomerulonephritis', 'Mitral Valve Prolapse-increase-SIRT1', 'Ventricular Dysfunction-increase-SIRT1', 'Mitral Valve Prolapse-increase-PRKAA1', 'Ventricular Dysfunction-increase-PRKAA1', 'Inflammation-include-Alzheimer Disease', 'CXCR2-include-Inflammation', 'CXCR2-linked-Alzheimer Disease', 'FPR2-include-Inflammation', 'FPR2-linked-Alzheimer Disease', 'GRB2-include-Inflammation', 'MAP1LC3A-lost-RECQL4', 'GRB2-linked-Alzheimer Disease', 'IFNAR1-include-Inflammation', 'IFNAR1-linked-Alzheimer Disease', 'Genetic Diseases, Inborn-characterized-Neoplasms', 'WRN-linked-Genetic Diseases, Inborn', 'RECQL4-linked-Genetic Diseases, Inborn', 'CRH-stimulate-POMC', 'Diabetes Insipidus, Neurogenic-stimulate-Hypernatremia', 'Disease Progression-associated-Hypernatremia', 'Hypernatremia-associated-Disease Progression', 'Disease Progression-stimulate-Hypernatremia', 'Diabetes Insipidus, Neurogenic-supply-CRH', 'Disease Progression-associated-CRH', 'CRH-associated-Disease Progression', 'Disease Progression-supply-CRH', 'CRH-stimulate-Hypernatremia', 'Diabetes Insipidus, Neurogenic-stimulate-POMC', 'Disease Progression-associated-POMC', 'POMC-associated-Disease Progression', 'Disease Progression-stimulate-POMC', 'POMC-stimulate-Hypernatremia', 'AQR-reveal-Hyperglycemia', 'AQR-confirm-CDKN1A', 'PLAU-induced-AQR', 'PLAU-reveal-Hyperglycemia', 'AQR-promote-Heart Arrest', 'PLAU-rescue-Inflammation', 'Inflammation-be in-AQR', 'Inflammation-induced-AQR', 'CDKN2B-encode-CDKN2A', 'CDKN2B-encode-CDKN2B-AS1', 'CDKN2A-encode-CDKN2B-AS1', 'CDKN2A-in RNA be-CDKN2B-AS1', 'CDKN2B-associated-Neoplasms', 'Neoplasms-associated-CDKN2B', 'CDKN2B-encode-Neoplasms', 'CDKN2A-associated-Neoplasms', 'Neoplasms-associated-CDKN2A', 'CDKN2B-AS1-associated-Neoplasms', 'Neoplasms-associated-CDKN2B-AS1', 'CELSR2-correlated-Coronary Artery Disease', 'PSRC1-correlated-Coronary Artery Disease', 'SORT1-correlated-Coronary Artery Disease', 'RUNX2-observed-Calcinosis', 'MGP-observed-Calcinosis', 'Inflammation-use-NFKB1', 'CISD2-selected-APOE', 'Dementia-modify-Hypertension', 'rs223330-selected-CISD2', 'rs223331-modify-APOE', 'CISD2-selected-Hypertension', 'Dementia-modify-APOE', 'COL1A1-downregulate-Osteoporotic Fractures', 'rs223331-modify-Hypertension', 'MMP2-downregulate-Osteoporotic Fractures', 'MMP13-downregulate-Osteoporotic Fractures', 'CAV1-play-Triglycerides', 'Osteoporosis-associated-CD4', 'CD4-associated-Osteoporosis', 'AGPAT2-play-Triglycerides', 'MMP9-downregulate-Osteoporotic Fractures', 'Osteoporosis-associated-IL2', 'IL2-associated-Osteoporosis', 'LPIN1-play-Triglycerides', 'PDGFA-downregulate-Osteoporotic Fractures', 'Osteoporosis-return-Cholecalciferol', 'INS-play role besides-MAPT', 'MAPT-hallmark of-Alzheimer Disease', 'GPC5-include-Carcinogenesis', 'SST-include-Carcinogenesis', 'MYOC-cause-Glaucoma', 'Atherosclerosis-co-localize-WNT3A', 'PTEN-result-Fibrosis', 'PTEN-be in-Idiopathic Pulmonary Fibrosis', 'Bleomycin-reduced-PTEN', 'MLKL-involved-Alzheimer Disease', 'RIPK3-involved-Alzheimer Disease', 'CD7-be deficient on-Lymphoma, T-Cell, Cutaneous', 'Weight Loss-remain-Dwarfism, Pituitary', 'Weight Loss-present-Obesity', 'Obesity-correlate-SHBG', 'SHBG-studied-Dwarfism, Pituitary', 'GGH-remain after-Weight Loss', 'INS-studied-Dwarfism, Pituitary', 'Weight Loss-remain-SHBG', 'Obesity-present-SHBG', 'Weight Loss-remain-INS', 'Severe Acute Respiratory Syndrome-dysregulate-ANXA3', 'Obesity-present-INS', 'CTCF-influence-TMEM106B', 'IGF1-release-CCN2', 'Severe Acute Respiratory Syndrome-dysregulate-H1-2', 'rs1990620-recruit-CTCF', 'Severe Acute Respiratory Syndrome-dysregulate-RASA3', 'IGF1-release-Idiopathic Pulmonary Fibrosis', 'Severe Acute Respiratory Syndrome-dysregulate-HBA1', 'Severe Acute Respiratory Syndrome-dysregulate-TFRC', 'CD4-terminate-Infections', 'CD8A-terminate-Infections', 'CTSB-visualize-VWF', 'Neoplasms-visualize-VWF', 'KITLG-induce-Gastrointestinal Stromal Tumors', 'KIT-induce-Gastrointestinal Stromal Tumors', 'Alzheimer Disease-expressed-GPM6A', 'Alzheimer Disease-expressed-IGF2BP2', 'Infliximab-activate-NOS3', 'Infliximab-activate-NOS1', 'Pigmentation Disorders-identify-IRF4', 'Pigmentation Disorders-identify-MC1R', 'Pigmentation Disorders-identify-rs12203592', 'Pigmentation Disorders-identify-rs6059655', 'IRF4-contribute-Pigmentation Disorders', 'MC1R-contribute-Pigmentation Disorders', 'BNC2-contribute-Pigmentation Disorders', 'KLF2-factor against-Atherosclerosis', 'ADIPOQ-associate-Diabetes Mellitus', 'Diabetes Mellitus-associate-ADIPOQ', 'IL6-associate-Diabetes Mellitus', 'Diabetes Mellitus-associate-IL6', 'Inflammation-include-TNFRSF1A', 'Inflammation-include-TNFRSF1B', 'Inflammation-include-CRP', 'FGFR2-risk of-Pulmonary Disease, Chronic Obstructive', 'FGFR2-affect-Pulmonary Disease, Chronic Obstructive', 'MGAT5-affect-Pulmonary Disease, Chronic Obstructive', 'FGFR2-be in-Pulmonary Disease, Chronic Obstructive', 'Osteosarcoma-mediated-SIRT1', 'EGFR-lead-STAT3', 'Osteosarcoma-mediated-FOXO3', 'Lung Injury-activate-EGFR', 'Lung Injury-lead to-STAT3', 'OGG1-prevent-Death', 'SIRT3-prevent-Death', 'STAT1-inhibit-STAT3', 'VIP-drive-GNRH1', 'Hypothalamic Diseases-remain-GNRH1', 'IGF1-lead-SIRT1', 'TTR-reduced-Alzheimer Disease', 'GFAP-found-Wounds and Injuries', 'GFAP-found-Seizures', 'GFAP-found-Gliosis', 'WRN-influence-ISYNA1', 'BACE1-contribute-OCLN', 'BACE1-contribute-Cerebral Amyloid Angiopathy', 'BACE1-contribute-Hemorrhage', 'Inflammation-reflect-Cardiomyopathies', 'Inflammation-reflect-CRP', 'COMT-associated-Deglutition Disorders', 'Deglutition Disorders-associated-COMT', 'BDNF-associated-Deglutition Disorders', 'Deglutition Disorders-associated-BDNF', 'Infections-associated-CD4', 'CD4-associated-Infections', 'Infections-associated-CD8A', 'CD8A-associated-Infections', 'Aortic Aneurysm, Abdominal-decrease-PTGER4', 'SIRT6-inhibit-COL1A1', 'SIRT6-prompt-MMP1', 'COL1A1-prompt-MMP1', 'COMT-predict-Deglutition Disorders', 'MMP1-prompt-COL3A1', 'BDNF-predict-Deglutition Disorders', 'rs165599-predict-Deglutition Disorders', 'rs10835211-predict-Deglutition Disorders', 'PAX8-presented-MTOR', 'CRP-determined-Death', 'STMN1-presented-MTOR', 'CRP-determined-Infections', 'Ovarian Neoplasms-presented-MTOR', 'SAA1-determined-Death', 'SAA1-determined-Infections', 'Leukemia, Myeloid, Acute-mediated-SPI1', 'Leukemia, Myeloid, Acute-mediated-IRF8', 'DOT1L-related-CDKN1A', 'DOT1L-related-Heart Arrest', 'Coronary Artery Disease-show-Triglycerides', 'Cholesterol-be in-Coronary Artery Disease', 'QPCT-associated-Hypertension', 'Hypertension-associated-QPCT', 'CYP11B2-associated-Hypertension', 'Hypertension-associated-CYP11B2', 'NR2C2-regulate-ATM', 'NR2C2-function-Neoplasms', 'NR2C2-prevent-Neoplasms', 'Neoplasms-regulate-ATM', 'Thymoma-involve-Myasthenia Gravis', 'Myasthenia Gravis-be with-Thymoma', 'Thymoma-involved-Myasthenia Gravis', 'IL2-involved-Myasthenia Gravis', 'IL6-involved-Myasthenia Gravis', 'INS-generate-Death', 'MMP12-co-express-ATL1', 'MMP12-co-express in-Neurodegenerative Diseases', 'MMP12-found-Neurodegenerative Diseases', 'Heart Arrest-follow-CDKN2A', 'TP53-follow-Heart Arrest', 'Carcinoma, Non-Small-Cell Lung-provide-RAB8A', 'RAB8A-provide-Neoplasms', 'RAB8A-involved-Carcinoma, Non-Small-Cell Lung', 'VASH1-augment-SIRT1', 'VASH1-augment-SOD2', 'VASH1-prevent-SIRT1', 'VASH1-prevent-Lung Injury', 'SOD2-prevent-Lung Injury', 'VASH1-improve-SOD2', 'VASH1-improve-SIRT1', 'SIRT1-prevent-Lung Injury', 'UAP1-show-UAP1L1', 'UAP1L1-involved-Sugars', 'UAP1-involved-Sugars', 'HDAC1-compare-CDK5', 'HDAC1-compare-Neurodegenerative Diseases', 'HDAC1-implicated-Neurodegenerative Diseases', 'CDK5-implicated-Neurodegenerative Diseases', 'FABP4-act-INS', 'FABP4-reported-Atherosclerosis', 'FABP4-associated-INS', 'INS-associated-FABP4', 'FABP4-associated-Obesity', 'Obesity-associated-FABP4', 'FABP4-associated-Dyslipidemias', 'Dyslipidemias-associated-FABP4', 'FABP4-associated-PCSK9', 'PCSK9-associated-FABP4', 'FABP4-associated-Atherosclerosis', 'Atherosclerosis-associated-FABP4', 'FABP4-associated-Cholesterol', 'Cholesterol-associated-FABP4', 'FABP4-associated-Kidney Diseases', 'Kidney Diseases-associated-FABP4', 'PCSK9-correlated-FABP4', 'Cholesterol-correlated-FABP4', 'FABP4-lead-Dyslipidemias', 'PCSK9-lead-Dyslipidemias', 'ASGR1-reversed-CERS2', 'ASGR1-decrease-Carcinoma, Hepatocellular', 'Carcinoma, Hepatocellular-reversed-CERS2', 'Carcinoma, Hepatocellular-be with-CERS2', 'ASGR1-act-Carcinoma, Hepatocellular', 'Carcinoma, Hepatocellular-act-CERS2', 'SIRT1-render-Doxorubicin', 'Prostatic Neoplasms-investigated-Prostatic Hyperplasia', 'CYP3A4-investigated-Prostatic Hyperplasia', 'VDR-investigated-Prostatic Hyperplasia', 'ACE2-related-Obesity', 'ACE2-related-Diabetes Mellitus', 'FOXO3-be in-Ovarian Neoplasms', 'RREB1-target-Melanoma', 'MYB-target-Melanoma', 'PARP1-approve-VCAM1', 'CCND1-target-Melanoma', 'APLN-drive-AKT1', 'APLN-shown-AKT1', 'PARP1-approve-Cerebral Infarction', 'TNFSF11-grant-Osteolysis', 'TNF-grant-Osteolysis', 'Neoplasms-suggest-Lymphoma, B-Cell', 'CXCL8-elevated-Malaria', 'IL5-compare-Malaria', 'CXCL8-compare-Malaria', 'UBE2C-ubiquitinate-von Hippel-Lindau Disease', 'UBE2C-mediate-Inflammation', 'SORL1-linked-Alzheimer Disease', 'MAP4K3-phosphorylate-IQGAP1', 'MAP4K3-phosphorylate-CDC42', 'Breast Neoplasms-contribute-PLAU', 'MAP4K3-activate-Neoplasms', 'Breast Neoplasms-contribute-PLAUR', 'IQGAP1-activate-Neoplasms', 'MAP4K3-cloned-MAPK8', 'MAP4K3-identify-MAPK8', 'Ataxia-associated-GGH', 'GGH-associated-Ataxia', 'Ataxia-associated-IGF1', 'IGF1-associated-Ataxia', 'INS-support-ADIPOQ', 'INS-support-Hyperinsulinism', 'Osteoporosis-target-MAPK8', 'HIV Infections-associated-CD4', 'CD4-associated-HIV Infections', 'Osteoporosis-target-AKT1', 'Osteoporosis-target-MAPK1', 'ADIPOQ-Fasting-Ghrelin', 'INS-Fasting-Ghrelin', 'Glucose-Fasting-Ghrelin', 'MVP-linked-ABCB1', 'Leukemia, Myeloid, Acute-linked-Coinfection', 'TNFSF11-be lower compare-Osteoporosis', 'MVP-linked-Coinfection', 'TNFRSF11B-be lower compare-Osteoporosis', 'MVP-be important predictor In-Neoplasms', 'MVP-be important predictor of-Leukemia, Myeloid, Acute', 'Leukemia, Myeloid, Acute-linked-ABCB1', 'Adenomatous Polyposis Coli-linked-Neoplasms', 'Leukemia, Myeloid, Acute-associated-RUNX1', 'RUNX1-associated-Leukemia, Myeloid, Acute', 'Leukemia, Myeloid, Acute-associated-IDH2', 'IDH2-associated-Leukemia, Myeloid, Acute', 'SDC2-linked-Neoplasms', 'VIM-linked-Neoplasms', 'MGMT-linked-Neoplasms', 'SFRP1-linked-Neoplasms', 'SFRP2-linked-Neoplasms', 'NDRG4-linked-Neoplasms', 'Hypothalamic Neoplasms-recognized-INS', 'Hypothalamic Neoplasms-recognized-HCRT', 'Hypothalamic Neoplasms-recognized-LEP', 'LEP-associated-Hypothalamic Neoplasms', 'Hypothalamic Neoplasms-associated-LEP', 'INS-associated-Hypothalamic Neoplasms', 'Hypothalamic Neoplasms-associated-INS', 'BGLAP-compare-Osteoporosis', 'BGLAP-compare-Osteoarthritis', 'SPP1-compare-Osteoporosis', 'SPP1-compare-Osteoarthritis', 'BGLAP-characterize-Osteoporotic Fractures', 'BGLAP-found-SPP1', 'BGLAP-found-SOST', 'BGLAP-lost-Osteoporosis', 'BGLAP-lost-Osteoarthritis', 'Osteoporosis-found-BGLAP', 'SPP1-characterize-Osteoporotic Fractures', 'Osteoarthritis-found-BGLAP', 'LXN-correlate-Sarcopenia', 'SPP1-lost-Osteoporosis', 'CIB2-correlate-Sarcopenia', 'SPP1-lost-Osteoarthritis', 'PEA15-correlate-Sarcopenia', 'FGD1-correlate-Sarcopenia', 'PLCB1-correlate-Sarcopenia', 'SEMA4G-correlate-Sarcopenia', 'ADARB1-correlate-Sarcopenia', 'UPF3A-correlate-Sarcopenia', 'CSTB-correlate-Sarcopenia', 'COL3A1-correlate-Sarcopenia', 'HMOX1-show-NFE2L2', 'CD99-correlate-Sarcopenia', 'NQO1-show-NFE2L2', 'ETV3-correlate-Sarcopenia', 'FJX1-correlate-Sarcopenia', 'NFE2L2-show-KEAP1', 'Progeria-show-HMOX1', 'Progeria-show-NFE2L2', 'MAPT-enhance-CDK5', 'MAPT-enhance-Drug-Related Side Effects and Adverse Reactions', 'CDK5-enhance-Drug-Related Side Effects and Adverse Reactions', 'RBMS3-expressed-Melanoma', 'SIRT1-regulate cell survival via-TP53', 'Infections-raised-ACE2', 'Infections-raised-ACE', 'Bone Diseases, Endocrine-emerge-Renal Insufficiency, Chronic', 'Bone Diseases, Endocrine-mediated-FGF23', 'FGF23-emerge-Renal Insufficiency, Chronic', 'Bone Diseases, Endocrine-mediated-KL', 'KL-emerge-Renal Insufficiency, Chronic', 'Dementia-increase-SIRT1', 'Dementia-increase-TLR4', 'Nerve Degeneration-reflect-Demyelinating Diseases', 'SIRT1-be with-Inflammation', 'RACK1-demonstrated-PRRT2', 'SIRT1-be in-Dementia', 'TLR4-increase-Dementia', 'PRRT2-demonstrated-Alzheimer Disease', 'MBP-reflect-Demyelinating Diseases', 'TLR4-increase-Alzheimer Disease', 'SIRT1-increase-Dementia', 'SIRT1-increase-Alzheimer Disease', 'CD4-lack-CCR7', 'Infections-lack-CD4', 'Infections-express-TNFRSF18', 'Neoplasms-express-MYOD1', 'Neoplasms-express-DES', 'Neoplasms-express-MYOG', 'ASAH1-treat-Parkinson Disease', 'GBA2-treat-Parkinson Disease', 'Neoplasms-block-GZMB', 'Werner Syndrome-characterized-Neoplasms', 'WRN-associated-Genetic Diseases, Inborn', 'Genetic Diseases, Inborn-associated-WRN', 'WRN-associated-Werner Syndrome', 'Werner Syndrome-associated-WRN', 'WRN-associated-Neoplasms', 'Neoplasms-associated-WRN', 'RECQL4-associated-Genetic Diseases, Inborn', 'Genetic Diseases, Inborn-associated-RECQL4', 'RECQL4-associated-Werner Syndrome', 'Werner Syndrome-associated-RECQL4', 'RECQL4-associated-Neoplasms', 'Neoplasms-associated-RECQL4', 'PIF1-reduce-Neoplasms', 'IAPP-suggest-CALCA', 'IAPP-suggest-Pancreatitis', 'SLC20A1-affected-Calcitriol', 'XPR1-affected-Calcitriol', 'CDKN1A-upregulated-Pulmonary Disease, Chronic Obstructive', 'HIF1A-associate-Pulmonary Disease, Chronic Obstructive', 'Pulmonary Disease, Chronic Obstructive-associate-HIF1A', 'HIF1A-upregulated-Pulmonary Disease, Chronic Obstructive', 'MXD1-associate-Pulmonary Disease, Chronic Obstructive', 'Pulmonary Disease, Chronic Obstructive-associate-MXD1', 'MXD1-upregulated-Pulmonary Disease, Chronic Obstructive', 'SOD2-associate-Pulmonary Disease, Chronic Obstructive', 'Pulmonary Disease, Chronic Obstructive-associate-SOD2', 'HIC1-inhibitor of-SIRT1', 'INS-result in-AKT1', 'INS-result-AKT1', 'INS-be impaired by-Fructose', 'Fructose-result-AKT1', 'SERPINF1-result-CASP3', 'DYNLT3-reduce-Breast Neoplasms', 'ALX4-reduce-Breast Neoplasms', 'PCSK9-bind-LDLR', 'Primary Ovarian Insufficiency-show-PRKAA2', 'Primary Ovarian Insufficiency-show-LEP', 'PCSK9-underlie-Aneurysm', 'TNFSF13-bind sulfate proteoglycans Contrary-TNFSF13B', 'TNFSF13B-bind-Heparitin Sulfate', 'TNFSF13-bind-Heparitin Sulfate', 'ABCA1-associated-CFH', 'CFH-associated-ABCA1', 'ABCA1-associated-rs1061170', 'rs1061170-associated-ABCA1', 'Heart Arrest-give-PLK1', 'Heart Arrest-give-MCM2', 'Heart Arrest-give-MCM3', 'NGF-antagonize-NTRK1', 'MTOR-actions in-Intellectual Disability', 'MTOR-parallel-Intellectual Disability', 'Pain-treated-NGF', 'Pain-antagonize-NGF', 'KL-parallel-Intellectual Disability', 'VDR-parallel-Intellectual Disability', 'Pain-antagonize-NTRK1', 'Death-correlate-CD4', 'Death-correlate-CD8A', 'Ghrelin-measured-INS', 'rs6311-be in-HTR2A', 'Inflammation-defined-CRP', 'rs690705-be in-RFC3', 'HTR2A-include-Alzheimer Disease', 'SIRT1-discuss-PRKAB1', 'RFC3-include-Alzheimer Disease', 'rs6311-include-Alzheimer Disease', 'rs6313-include-Alzheimer Disease', 'rs690705-include-Alzheimer Disease', 'NFE2L2-activated-Neoplasms', 'Neoplasms-activated-KEAP1', 'Pulmonary Disease, Chronic Obstructive-reduce-Heart Arrest', 'Pulmonary Disease, Chronic Obstructive-reduce-MMP9', 'NPY4R-identify-Memory Disorders', 'Dementia-observed-GDF15', 'Colonic Neoplasms-include-Neoplasms', 'MUTYH-encode-TFAM', 'OGG1-encode-TFAM', 'POLB-encode-TFAM', 'Neoplasms-detected-GSN', 'POLG-encode-TFAM', 'TFAM-encode-Alzheimer Disease', 'BCHE-associated-Alzheimer Disease', 'Alzheimer Disease-associated-BCHE', 'MLKL-contribute-APOE', 'MLKL-contribute-Alzheimer Disease', 'Colorectal Neoplasms-show-Adenoma', 'Colorectal Neoplasms-show-EREG', 'EREG-progress-Adenoma', 'Colorectal Neoplasms-show-IGF2', 'IGF2-progress-Adenoma', 'Colorectal Neoplasms-show-TUSC3', 'TUSC3-progress-Adenoma', 'Colorectal Neoplasms-show-MYOD1', 'MYOD1-progress-Adenoma', 'Glomerulonephritis-associated-Fibrosis', 'Fibrosis-associated-Glomerulonephritis', 'Glomerulonephritis-correlate-Adenocarcinoma', 'Glomerulonephritis-correlate with-CDKN2A', 'CDKN2A-associated-Fibrosis', 'Fibrosis-associated-CDKN2A', 'Adenocarcinoma-associated-CDKN2A', 'CDKN2A-associated-Adenocarcinoma', 'Glomerulonephritis-correlate-TP53', 'Fibrosis-associated-TP53', 'TP53-associated-Fibrosis', 'Adenocarcinoma-associated-TP53', 'TP53-associated-Adenocarcinoma', 'Glomerulonephritis-correlate-HSPA5', 'DKC1-pose-TERT', 'DKC1-pose-TERC', 'Bone Marrow Failure Disorders-involve-DKC1', 'Trichothiodystrophy Syndromes-identified-ERCC3', 'Idiopathic Pulmonary Fibrosis-involve-DKC1', 'Genetic Diseases, Inborn-linked-Neoplasms', 'Bone Marrow Failure Disorders-pose-TERT', 'Bone Marrow Failure Disorders-pose-TERC', 'APOE-validate-Alzheimer Disease', 'NTRK1-validate-Alzheimer Disease', 'MST1-regulate-Death', 'Brain Neoplasms-include-Nervous System Diseases', 'Cerebrovascular Disorders-include-Nervous System Diseases', 'Neuromuscular Diseases-include-Nervous System Diseases', 'STK3-shed-Nervous System Diseases', 'BFSP1-cause-Cataract', 'BFSP2-cause-Cataract', 'FOXO3-contain-Lipofuscin', 'SIRT1-deacetylate-TP53', 'SIRT1-deacetylate-RELA', 'SIRT1-known-RELA', 'TP53-known-RELA', 'SIRT1-limit-Inflammation', 'PARK7-mediate-Parkinson Disease', 'Inflammation-known-RELA', 'SMAD3-reduce-Inflammation', 'Bone Diseases-related-Spinal Cord Injuries', 'TNFSF11-related-Spinal Cord Injuries', 'TNFRSF11B-related-Spinal Cord Injuries', 'PABPN1-show-Ocular Motility Disorders', 'NOX4-include-Bloom Syndrome', 'PARP1-include-Bloom Syndrome', 'SLC2A4-associated-INS', 'INS-associated-SLC2A4', 'TNFSF11-be in-Prolactinoma', 'TNFSF11-be higher in-Prolactinoma', 'ALPP-associated-TNFSF11', 'TNFSF11-associated-ALPP', 'TNFRSF11B-be higher in-Prolactinoma', 'TNFRSF11B-exclude-Prolactinoma', 'TNFSF11-play role in-Prolactinoma', 'TNFRSF11B-play role in-Prolactinoma', 'Heart Arrest-decrease-COL1A1', 'Heart Arrest-increase-ELN', 'MAPT-associated-SREBF1', 'SREBF1-associated-MAPT', 'Parkinson Disease-associated-Hypokinesia', 'Hypokinesia-associated-Parkinson Disease', 'Parkinson Disease-associated-Gait Disorders, Neurologic', 'Gait Disorders, Neurologic-associated-Parkinson Disease', 'Parkinson Disease-associated-Muscle Rigidity', 'Muscle Rigidity-associated-Parkinson Disease', 'Parkinson Disease-discover-Tremor', 'Hypokinesia-discover-Gait Disorders, Neurologic', 'Hypokinesia-base-Muscle Rigidity', 'Hypokinesia-discover-Muscle Rigidity', 'Hypokinesia-discover-Tremor', 'MAPT-associated-Hypokinesia', 'Hypokinesia-associated-MAPT', 'MAPT-base-Muscle Rigidity', 'Parkinson Disease-associated-CCDC62', 'CCDC62-associated-Parkinson Disease', 'CCDC62-associated-Hypokinesia', 'Hypokinesia-associated-CCDC62', 'CCDC62-base-Muscle Rigidity', 'Parkinson Disease-associated-SREBF1', 'SREBF1-associated-Parkinson Disease', 'Hypokinesia-associated-SREBF1', 'SREBF1-associated-Hypokinesia', 'SREBF1-base-Muscle Rigidity', 'Parkinson Disease-associated-GAK', 'GAK-associated-Parkinson Disease', 'Hypokinesia-discover-GAK', 'Parkinson Disease-associated-rs11868035', 'rs11868035-associated-Parkinson Disease', 'Hypokinesia-associated-rs11868035', 'rs11868035-associated-Hypokinesia', 'rs11868035-base-Muscle Rigidity', 'Parkinson Disease-associated-rs356220', 'rs356220-associated-Parkinson Disease', 'Hypokinesia-associated-rs356220', 'rs356220-associated-Hypokinesia', 'Parkinson Disease-associated-rs1564282', 'rs1564282-associated-Parkinson Disease', 'Hypokinesia-associated-rs1564282', 'rs1564282-associated-Hypokinesia', 'NPM1-decrease-Leukemia, Myeloid, Acute', 'Inflammation-enhanced-Huntington Disease', 'NFKB1-enhanced-Huntington Disease', 'NFKB2-enhanced-Huntington Disease', 'CIAO2B-decrease-TERT', 'KL-observed-Renal Insufficiency', 'CRP-associated-FTO', 'FTO-associated-CRP', 'KL-associated-FGF23', 'FGF23-associated-KL', 'Weight Loss-involve-TNF', 'Weight Loss-involve-CFD', 'Cardiovascular Diseases-characterized-Inflammation', 'Cardiovascular Diseases-linked-Myocardial Infarction', 'Cardiovascular Diseases-characterized-CRP', 'Plaque, Amyloid-be in-Alzheimer Disease', 'Plaque, Amyloid-nonaggregating-Alzheimer Disease', 'SOD1-decreased-Cartilage Diseases', 'SOD2-decreased-Cartilage Diseases', 'SOD3-decreased-Cartilage Diseases', 'SIRT7-silencing-ICAM1', 'SIRT7-attenuate-ICAM1', 'Prostatic Hyperplasia-include-KLF4', 'SIRT7-silencing-VCAM1', 'SIRT7-attenuate-VCAM1', 'Prostatic Hyperplasia-include-THBS4', 'SIRT7-silencing-CXCL8', 'SIRT7-attenuate-CXCL8', 'SIRT7-silencing-IL6', 'SIRT7-induce-IL6', 'Prostatic Hyperplasia-include-TGM3', 'Prostatic Hyperplasia-include-GRP', 'SIRT7-induce-PECAM1', 'SIRT7-attenuate-SNAI1', 'SIRT7-silencing-Lipopolysaccharides', 'SIRT7-induce-Lipopolysaccharides', 'Lipopolysaccharides-induce-ICAM1', 'Lipopolysaccharides-induce-VCAM1', 'TFRC-be common biomarkers-TF', 'Lipopolysaccharides-induce-CXCL8', 'Lipopolysaccharides-induce-IL6', 'Lipopolysaccharides-induce-PECAM1', 'Lipopolysaccharides-induce-SNAI1', 'SIRT7-be in-Stenosis, Pulmonary Artery', 'SIRT7-silencing-Stenosis, Pulmonary Artery', 'ICAM1-silencing-Stenosis, Pulmonary Artery', 'VCAM1-silencing-Stenosis, Pulmonary Artery', 'CXCL8-silencing-Stenosis, Pulmonary Artery', 'IL6-silencing-Stenosis, Pulmonary Artery', 'TFRC-be common biomarkers-Inflammation', 'TF-be common biomarkers-Inflammation', 'Stenosis, Pulmonary Artery-silencing-Lipopolysaccharides', 'Stenosis, Pulmonary Artery-induce-Lipopolysaccharides', 'MAP3K7-result-RUNX2', 'Alzheimer Disease-suggest-PICALM', 'Alzheimer Disease-suggest-TNK1', 'MAP3K7-result-Cleidocranial Dysplasia', 'REN-include-Cardiovascular Diseases', 'AGT-include-Cardiovascular Diseases', 'APOE-suggest-PICALM', 'APOE-suggest-TNK1', 'rs11722228-be in-SLC2A9', 'rs11722228-be in-ABCG2', 'TREM2-demonstrate-KLRK1', 'rs75932628-demonstrate-KLRK1', 'Alzheimer Disease-demonstrate-KLRK1', 'CDH1-suggest-Neoplasms', 'Leukoencephalopathies-caused-TREM2', 'Alzheimer Disease-be with-rs75932628', 'PRKAB1-accompanied-Death', 'SIRT1-deacetylate-FOXO3', 'SIRT1-deacetylate-FOXO4', 'SIRT1-potentiate-Heart Arrest', 'FOXO3-potentiate-Heart Arrest', 'FOXO4-potentiate-Heart Arrest', 'ATP5IF1-identify-PINK1', 'ATP5IF1-promote by-PRKN', 'ATP5IF1-identify-PRKN', 'ATP5IF1-trigger-PRKN', 'PINK1-underlie-Parkinsonian Disorders', 'Colorectal Neoplasms-measure-Neoplasms', 'IL17A-measure-Neoplasms', 'PRKN-underlie-Parkinsonian Disorders', 'Leukemia, Lymphoid-be in-IKZF3', 'IL6-measure-Neoplasms', 'IGF1R-reduced-Alzheimer Disease', 'Adenocarcinoma-demonstrate-PCNA', 'GH1-release-GHRH', 'GH1-release-Hypothalamic Diseases', 'HSP90AA1-activated-NLRP3', 'HSP90AA1-promote-Inflammation', 'NLRP3-promote-Inflammation', 'Femoral Neck Fractures-associated-INS', 'INS-associated-Femoral Neck Fractures', 'Femoral Neck Fractures-associated-CRP', 'CRP-associated-Femoral Neck Fractures', 'Femoral Neck Fractures-associated-ADIPOQ', 'ADIPOQ-associated-Femoral Neck Fractures', 'Femoral Neck Fractures-associated-BGLAP', 'BGLAP-associated-Femoral Neck Fractures', 'NTRK1-receptor for-NGF', 'NTRK1-expressed-Pigmentation Disorders', 'INS-mediated-AKT1', 'BRCA2-be with-Breast Neoplasms', 'ETFA-encoded-ETFDH', 'INS-exert-Glucose', 'INS-exert-Glycogen', 'Glucose-include-AKT1', 'ETFB-encoded-ETFDH', 'Glycogen-include-AKT1', 'INS-exert-Fatty Acids, Nonesterified', 'Fatty Acids, Nonesterified-include-AKT1', 'Fatty Acids-encoded-ETFA', 'FABP4-related-Fatty Acids', 'PLIN1-related-Fatty Acids', 'Fatty Acids-encoded-ETFB', 'ADIPOQ-related-Fatty Acids', 'Multiple Acyl Coenzyme A Dehydrogenase Deficiency-encoded-ETFA', 'Genetic Diseases, Inborn-encoded-ETFA', 'Multiple Acyl Coenzyme A Dehydrogenase Deficiency-encoded-ETFB', 'Genetic Diseases, Inborn-encoded-ETFB', 'TDRD7-linked-Cataract', 'CAPRIN2-linked-Cataract', 'HAVCR2-compare-ITGAE', 'CXCL12-altered-Neoplasms', 'Heart Arrest-recover-SIRT1', 'Heart Arrest-reveal-NOS3', 'Heart Arrest-recover-NOS3', 'Heart Failure-have increase-PTH', 'Heart Failure-increase-ADIPOQ', 'Heart Failure-increase-TNFRSF11B', 'MSTN-increase-FST', 'CRP-related-Diabetes Mellitus', 'MTOR-block-CRTC1', 'MTOR-lead-Infections', 'CRTC1-lead to-Infections', 'HSD11B1-contribute-INS', 'Myocardial Infarction-mobilized-GFAP', 'BMPR1B-associated-Death', 'Death-associated-BMPR1B', 'IFITM3-associated-Death', 'Death-associated-IFITM3', 'HSD11B1-contribute-Obesity, Abdominal', 'Cerebral Infarction-mobilized-GFAP', 'NLRC5-associated-Death', 'Death-associated-NLRC5', 'Myocardial Infarction-mobilized-OLIG1', 'MIR1973-associated-Death', 'Death-associated-MIR1973', 'Cerebral Infarction-mobilized-OLIG1', 'Myocardial Infarction-mobilized-OLIG2', 'Cerebral Infarction-mobilized-OLIG2', 'Myocardial Infarction-mobilized-SOX2', 'Cerebral Infarction-mobilized-SOX2', 'Myocardial Infarction-mobilized-VWF', 'Cerebral Infarction-mobilized-VWF', 'SERINC2-associated-Death', 'Death-associated-SERINC2', 'CHST12-associated-Death', 'Death-associated-CHST12', 'FSTL3-investigate-ACVR2A', 'FSTL3-use-ACVR2A', 'IFITM3-linked-Communicable Diseases', 'TRIM63-linked-Communicable Diseases', 'NLRC5-linked-Communicable Diseases', 'MT2A-linked-Communicable Diseases', 'SMURF1-identified-ACVR2A', 'MARCKSL1-linked-Communicable Diseases', 'Heart Failure-investigate-ACVR2A', 'Heart Failure-use-ACVR2A', 'IAPP-result-CAT', 'IAPP-enhance-NOS2', 'IAPP-result-Glutathione', 'BACH1-include-NFE2L2', 'BACH1-include-KEAP1', 'Space Motion Sickness-include-NFE2L2', 'Space Motion Sickness-include-KEAP1', 'BACH1-increase-Space Motion Sickness', 'ARID1A-observed-Neoplasms', 'MLH1-indicate-ARID1A', 'Neoplasms-indicate-Microsatellite Instability', 'MLH1-observed-Neoplasms', 'MLH1-indicate-Microsatellite Instability', 'PPM1D-aggravate-OCLN', 'PPM1D-induced-Lipopolysaccharides', 'OCLN-induced-Lipopolysaccharides', 'PPM1D-protect-SHH', 'PPM1D-protect-Lipopolysaccharides', 'MYOD1-retained-Muscular Diseases', 'NOS1-miss-DMD', 'Muscular Dystrophy, Duchenne-miss-NOS1', 'Muscular Dystrophy, Duchenne-miss-DMD', 'MYPN-associated-SRF', 'SRF-associated-MYPN', 'Muscle Weakness-associated-SRF', 'SRF-associated-Muscle Weakness', 'GALC-support-Parkinson Disease', 'Psychosine-support-Parkinson Disease', 'Cholesterol-upregulation of-LDLR', 'Infections-associated-EOMES', 'EOMES-associated-Infections', 'TRIM59-found-Alzheimer Disease', 'KLF14-found-Alzheimer Disease', 'SERPINA4-inhibit-SIRT1', 'FGF21-activate-PRKAB1', 'FGF21-discuss-Metabolic Diseases', 'SOD2-increase-Hip Fractures', 'GPX3-increase-Hip Fractures', 'INS-fast-Glucose', 'FGF21-enhance-INS', 'FGF21-increase-Glucose', 'INS-increase-Glucose', 'FGF21-decrease-Hyperglycemia', 'INS-decrease-Hyperglycemia', 'Glucose-decrease-Hyperglycemia', 'Glucose-lower-PPARG', 'Glucose-decrease-SLC2A4', 'rs139438201-be in-PMS2', 'rs139438201-show-GABRR3', 'rs199781816-show-GABRR3', 'CAT-include-PTK2B', 'PICALM-associated-Alzheimer Disease', 'Alzheimer Disease-associated-PICALM', 'Glutathione-include-PTK2B', 'rs1801133-associated-Alzheimer Disease', 'Alzheimer Disease-associated-rs1801133', 'SRSF2-correlate-Leukemia, Myeloid, Acute', 'rs11136000-associated-Alzheimer Disease', 'Alzheimer Disease-associated-rs11136000', 'rs6701713-associated-Alzheimer Disease', 'Alzheimer Disease-associated-rs6701713', 'SF3B1-correlate-Leukemia, Myeloid, Acute', 'Myelodysplastic Syndromes-be with-U2AF1', 'U2AF1-associated-Myelodysplastic Syndromes', 'Myelodysplastic Syndromes-associated-U2AF1', 'SRSF2-associated-Myelodysplastic Syndromes', 'Myelodysplastic Syndromes-associated-SRSF2', 'SIRT6-known-SIRT7', 'USF3-transactivate-WNT16', 'USF3-antagonize-WNT16', 'SIRT6-demonstrated-Cardiomegaly', 'SIRT6-attenuate-Cardiomegaly', 'Cardiomegaly-known-SIRT7', 'USF3-antagonize repression by-TWIST1', 'rs4531631-confer-USF3', 'rs4531631-transactivate-TCF12', 'Osteoporosis-located in-WNT16', 'Osteoporosis-confer-USF3', 'TNFSF11-in allele be-rs4531631', 'rs28384991-associated-Breast Neoplasms', 'Breast Neoplasms-associated-rs28384991', 'rs799917-associated-Breast Neoplasms', 'Breast Neoplasms-associated-rs799917', 'GH1-attribute-CRH', 'Alzheimer Disease-associated-IL4', 'IL4-associated-Alzheimer Disease', 'Alzheimer Disease-associated-IL5', 'IL5-associated-Alzheimer Disease', 'Obesity-quantify-LEP', 'Obesity-quantify-ADIPOQ', 'Docosahexaenoic Acids-attenuate-CASP3', 'VEGFB-associated-Death', 'Death-associated-VEGFB', 'FLT4-associated-Death', 'Death-associated-FLT4', 'PSEN1-cause-Alzheimer Disease', 'PSEN2-cause-Alzheimer Disease', 'CRP-associated-Breast Neoplasms', 'Breast Neoplasms-associated-CRP', 'CRP-evaluate-Neoplasms', 'CAMK4-activate-AKT1', 'CAMK4-activate-SIRT1', 'CAMK4-find-FOXO3', 'FGF23-correlate-CST3', 'FGF23-correlate-LCN2', 'FGF23-correlate-Hypertension', 'MTOR-implicated-Neoplasms', 'MTOR-include-Neoplasms', 'AKT1-include-Neoplasms', 'UCP2-involved-INS', 'UCP2-involved-Neoplasms', 'FOXD3-treated-MIR377', 'UTF1-treated-MIR377', 'FOXO1-fill-Neoplasms', 'FOXO1-fill-Diabetes Mellitus', 'FOXO1-fill-Infertility, Female', 'FOXO1-fill-Neurodegenerative Diseases', 'Mastocytosis, Systemic-fill-FOXO1', 'FOXO3-fill-Neoplasms', 'Drug-Related Side Effects and Adverse Reactions-include-Skin Diseases', 'IL6-include-Skin Diseases', 'FOXO3-fill-Diabetes Mellitus', 'FOXO3-fill-Infertility, Female', 'FOXO3-fill-Neurodegenerative Diseases', 'Mastocytosis, Systemic-fill-FOXO3', 'Neoplasms-fill-FOXO4', 'Diabetes Mellitus-fill-FOXO4', 'Infertility, Female-fill-FOXO4', 'Neurodegenerative Diseases-fill-FOXO4', 'Mastocytosis, Systemic-fill-FOXO4', 'Diabetes Mellitus-extend-INS', 'Diabetes Mellitus-extend-Glucose', 'Progeria-reduced-TIMP1', 'Progeria-reduced-TIMP2', 'Alzheimer Disease-implicated-DOC2A', 'Alzheimer Disease-implicated-SNX32', 'Alzheimer Disease-implicated-STX4', 'Alzheimer Disease-implicated-STX6', 'WDFY3-required-HTT', 'WDFY3-confer-Huntington Disease', 'Lipopolysaccharides-use-CD163', 'Lipopolysaccharides-use-CCL18', 'CAT-lead-GSR', 'CAT-lead-Ascorbic Acid', 'CAT-lead-Glutathione', 'SIRT1-lead-MMP1', 'Glucosamine-observed-VIM', 'MIR27A-lead-MMP1', 'Glucosamine-observed-FMOD', 'GBA-associate-Gaucher Disease', 'Gaucher Disease-associate-GBA', 'NFKBIZ-including-IL17A', 'ZC3H12A-including-IL17A', 'PIGR-including-IL17A', 'Colorectal Neoplasms-including-IL17A', 'ZC3H12A-be genes-Colorectal Neoplasms', 'PIGR-be genes-Colorectal Neoplasms', 'APOE-associated-Dementia, Vascular', 'Dementia, Vascular-associated-APOE', 'CRP-associated-Dementia, Vascular', 'Dementia, Vascular-associated-CRP', 'CRH-result-Hypogonadism', 'GNRH1-result-Hypogonadism', 'VDR-participate-FGF23', 'Calcitriol-participate-FGF23', 'TAT-associated-CD4', 'CD4-associated-TAT', 'TAT-impact-CD4', 'PPARG-receive-INS', 'PPARG-compare-Death', 'PPARG-show-Death', 'Death-receive-INS', 'CRP-associated-Alzheimer Disease', 'Alzheimer Disease-associated-CRP', 'IL6-associated-Alzheimer Disease', 'Alzheimer Disease-associated-IL6', 'Death-depend-MAPK1', 'Alzheimer Disease-include-CRP', 'ADH5-promote-UTRN', 'Alzheimer Disease-associated-TOMM40', 'TOMM40-associated-Alzheimer Disease', 'Alzheimer Disease-associated-ABCG1', 'ABCG1-associated-Alzheimer Disease', 'Alzheimer Disease-associated-MEF2C', 'MEF2C-associated-Alzheimer Disease', 'Death-be in-Diabetes Mellitus', 'Death-investigate-CRP', 'C1QA-include-Inflammation', 'FOXO3-include-Inflammation', 'Death-investigate-ALB', 'IL6-related-Fatty Acids, Omega-3', 'TERT-analyzed-Neoplasms', 'BRAF-analyzed-Neoplasms', 'CCK-delayed-Glucose', 'ADIPOQ-associated-Anemia', 'Anemia-associated-ADIPOQ', 'LEP-associated-Anemia', 'Anemia-associated-LEP', 'CDKN2A-reduce-MMP13', 'IL4-include-CXCL8', 'IL15-include-CXCL8', 'CHEK2-mutate-TP53', 'Ataxia Telangiectasia-mutate-CHEK2', 'Ataxia Telangiectasia-mutate-TP53', 'SIRT1-cause-FOXO1', 'SIRT1-cause-Prostatic Neoplasms', 'SIRT1-contribute-FOXO1', 'SIRT1-inhibit-FOXO1', 'SIRT1-contribute-Prostatic Neoplasms', 'FOXO1-contribute-Prostatic Neoplasms', 'PRKAB1-mediated-Neoplasms', 'Colorectal Neoplasms-cooperate-PRDX1', 'Colorectal Neoplasms-cooperate-NUDT1', 'SIRT1-function-PRKAB1', 'SIRT1-modulate-Neoplasms', 'PRKAB1-modulate-Neoplasms', 'Genetic Diseases, Inborn-be in-Dementia', 'Genetic Diseases, Inborn-include-Nerve Degeneration', 'Dementia-include-Nerve Degeneration', 'Dementia-lead-Nerve Degeneration', 'Genetic Diseases, Inborn-include-LRP1', 'Dementia-include-LRP1', 'Genetic Diseases, Inborn-include-TNF', 'Dementia-include-TNF', 'Genetic Diseases, Inborn-include-ACE', 'Dementia-include-ACE', 'Genetic Diseases, Inborn-include-BACE1', 'Dementia-include-BACE1', 'Genetic Diseases, Inborn-include-BCHE', 'Dementia-include-BCHE', 'Genetic Diseases, Inborn-include-CST3', 'Dementia-include-CST3', 'Genetic Diseases, Inborn-include-NOS3', 'Dementia-include-NOS3', 'Death-persist-Diabetes Mellitus', 'Death-persist-CRP', 'Tinnitus-improve in-Diabetes Mellitus', 'INS-improve in-Diabetes Mellitus', 'INS-interact-MAPT', 'INS-interact-Alzheimer Disease', 'MAPT-interact-Alzheimer Disease', 'LEP-reflect-ADIPOQ', 'Polycystic Ovary Syndrome-found-INS', 'Polycystic Ovary Syndrome-found-ADIPOQ', 'SELENOH-be sensitive than-SELENOT', 'SELENOH-be sensitive than-Immunologic Deficiency Syndromes', 'Progeria-encode-LMNA', 'Aging, Premature-caused-ZMPSTE24', 'TMEM106B-associated-Dementia', 'Dementia-associated-TMEM106B', 'GRN-associated-Dementia', 'Dementia-associated-GRN', 'IL6-associated-Neoplasms', 'Neoplasms-associated-IL6', 'IL6-associated-Prostatic Neoplasms', 'Prostatic Neoplasms-associated-IL6', 'OSM-elevated-Myasthenia Gravis', 'IL6-elevated-Myasthenia Gravis', 'KITLG-elevated-Myasthenia Gravis', 'DAG1-associated-MAPT', 'MAPT-associated-DAG1', 'DTNA-associated-MAPT', 'MAPT-associated-DTNA', 'SNTA1-associated-MAPT', 'MAPT-associated-SNTA1', 'DAG1-associated-Dementia', 'Dementia-associated-DAG1', 'DTNA-associated-Dementia', 'Dementia-associated-DTNA', 'SNTA1-associated-Dementia', 'Dementia-associated-SNTA1', 'SIRT1-associated-Neoplasms', 'Neoplasms-associated-SIRT1', 'PPARGC1A-compare-Lordosis', 'IL6-compare-Lordosis', 'S100A8-used-Infections', 'CXCL8-measured-Stomach Diseases', 'NAGLU-degrade-Glycosaminoglycans', 'INS-include-DMPK', 'DMPK-include-Neurologic Manifestations', 'Cataract-include-DMPK', 'Dyslipidemias-include-DMPK', 'Erectile Dysfunction-include-DMPK', 'REST-alter-GHR', 'DMPK-include-Hypogonadism', 'TAL1-alter-GHR', 'TCF12-alter-GHR', 'rs4130113-influence-REST', 'rs4130113-influence-TAL1', 'Glucose-fasting of-INS', 'rs4130113-influence-TCF12', 'Necrosis-characterize-IL6', 'rs4130113-alter-GHR', 'Nasal Polyps-expressed-SIRT6', 'SIRT6-studied-Inflammation', 'SIRT6-studied-Neoplasms', 'SIRT6-inhibit-HMGB1', 'SIRT6-enhance-HMGB1', 'SIRT6-stimulated-Lipopolysaccharides', 'HMGB1-stimulated-Lipopolysaccharides', 'SDHB-result-Head and Neck Neoplasms', 'SDHC-result-Head and Neck Neoplasms', 'SDHD-result-Head and Neck Neoplasms', 'rs11136000-link-CLU', 'rs11136000-link-APOE', 'Alzheimer Disease-associated-Lipid Metabolism Disorders', 'Lipid Metabolism Disorders-associated-Alzheimer Disease', 'SIRT1-enhance-NR3C1', 'rs11136000-link-Dementia', 'Glucose Intolerance-increase formation-INS', 'Amyloidosis-increase formation-INS', 'EGFR-benefit-Neoplasms', 'ALK-benefit-Neoplasms', 'AGER-cause-Inflammation', 'FGF23-expressed-Multiple Myeloma', 'KL-expressed-Multiple Myeloma', 'FGF23-increase mRNA for-EGR1', 'FGF23-increase-HPSE', 'FGF23-increase-Multiple Myeloma', 'HPSE-factor in-Multiple Myeloma', 'SRSF5-identify-LMNA', 'SRSF5-increase-LMNA', 'SRSF5-identify-Progeria', 'SRSF5-increase-Progeria', 'CNKSR1-cause-Drug Hypersensitivity', 'CD163-correlate-CCR2', 'CD163-correlate with-Fibrosis', 'CCR2-related to-Fibrosis', 'Hypoglycemia-represent-Pancreatitis', 'PPY-induce-Hypoglycemia', 'MTOR-be with-Immunologic Deficiency Syndromes', 'PPY-represent-Pancreatitis', 'INS-induce-Hypoglycemia', 'WRN-be with-Immunologic Deficiency Syndromes', 'INS-represent-Pancreatitis', 'Neoplasms-bind-Necrosis', 'RRM1-be prone to-Ventricular Fibrillation', 'RRM1-underscore-Ventricular Fibrillation', 'TNFAIP3-bind-Neoplasms', 'RRM2-be prone to-Ventricular Fibrillation', 'RRM2-underscore-Ventricular Fibrillation', 'TNFAIP3-bind to-Necrosis', 'SIRT1-induce-FOXO3', 'SIRT1-alleviate-Venous Thrombosis', 'Venous Thrombosis-induce-FOXO3', 'Thrombosis-play-Atherosclerosis', 'HNRNPA1-contain-Alzheimer Disease', 'AGER-evoke-Thrombosis', 'ANKRD26-play-Thrombocytopenia', 'RUNX1-play-Thrombocytopenia', 'ETV6-play-Thrombocytopenia', 'rs754486509-show-RUNX1', 'DAPK1-associated-Death', 'Death-associated-DAPK1', 'TERT-alter-INS', 'Neoplasms-downregulated-Colorectal Neoplasms', 'KL-serve-Colorectal Neoplasms', 'CDC20-show-BUB1B', 'BUB1B-show-Adenomatous Polyposis Coli', 'KL-inhibit-Colorectal Neoplasms', 'Colorectal Neoplasms-inhibit-PCNA', 'CHAT-correlate-SYP', 'Death-correlate-CHAT', 'CHAT-include-Alzheimer Disease', 'Death-correlate-SYP', 'SYP-include-Alzheimer Disease', 'SIRT6-improve-PRKAA2', 'SIRT6-improve-Metabolic Diseases', 'SIRT6-improve-Hypercholesterolemia', 'SIRT6-improve-Diabetes Mellitus', 'Metabolic Diseases-improve-PRKAA2', 'Hypercholesterolemia-improve-PRKAA2', 'Diabetes Mellitus-improve-PRKAA2', 'APOE-carry-Alzheimer Disease', 'COMT-carry-Alzheimer Disease', 'ERCC6-promote-HTRA3', 'ERCC6-promote-Mitochondrial Diseases', 'ERCC6-result-Mitochondrial Diseases', 'HTRA3-result-Mitochondrial Diseases', 'RECQL4-stimulate-POLB', 'RECQL4-display-Rothmund-Thomson Syndrome', 'POLB-display-Rothmund-Thomson Syndrome', 'Diabetes Mellitus, Type 2-show-INS', 'Diabetes Mellitus, Type 2-show-GIP', 'rs2155209-influence-Death', 'rs2155209-influence-Coronary Artery Disease', 'rs7963551-influence-Death', 'rs7963551-influence-Coronary Artery Disease', 'rs17105278-influence-Death', 'rs17105278-influence-Coronary Artery Disease', 'rs2735383-influence-Death', 'rs2735383-influence-Coronary Artery Disease', 'Heart Arrest-mediated-CDKN2A', 'Heart Arrest-regulate-CDKN1A', 'CDKN2A-associated-Heart Arrest', 'Heart Arrest-associated-CDKN2A', 'CDKN1A-associated-Heart Arrest', 'Heart Arrest-associated-CDKN1A', 'LEP-relate-INS', 'LEP-relate-IAPP', 'LEP-associated-IAPP', 'IAPP-associated-LEP', 'INS-associated-IAPP', 'IAPP-associated-INS', 'LEP-associated-Glucose', 'Glucose-associated-LEP', 'Heart Arrest-recruit-TNFRSF10B', 'INS-associated-Glucose', 'Glucose-associated-INS', 'INS-relate-Glucose', 'Heart Arrest-recruit-FAS', 'IAPP-associated-Glucose', 'Glucose-associated-IAPP', 'IAPP-relate-Glucose', 'Amyotrophic Lateral Sclerosis-play-TOLLIP', 'Amyotrophic Lateral Sclerosis-play-MAPK9', 'Amyotrophic Lateral Sclerosis-associated-CXCL1', 'CXCL1-associated-Amyotrophic Lateral Sclerosis', 'Coinfection-associated-Inflammation', 'Inflammation-associated-Coinfection', 'Coinfection-associated-CD4', 'CD4-associated-Coinfection', 'Coinfection-associated-CD8A', 'CD8A-associated-Coinfection', 'Coinfection-associated-CD38', 'CD38-associated-Coinfection', 'PRKAB1-regulate-FOXO3', 'PRKAB1-find-Neoplasms', 'APLN-associated-Sarcopenia', 'Sarcopenia-associated-APLN', 'HTRA1-associated-Sarcopenia', 'Sarcopenia-associated-HTRA1', 'von Willebrand Diseases-reviewed-F8', 'Hypercholesterolemia-associated-BDNF', 'BDNF-associated-Hypercholesterolemia', 'Hypercholesterolemia-associated-VEGFA', 'VEGFA-associated-Hypercholesterolemia', 'PRKAA2-limit-Osteoarthritis', 'AIF1-investigate-CFL1', 'AIF1-investigate-P2RY12', 'AIF1-use-MAPT', 'CFL1-investigate-CORO1A', 'CFL1-use-MAPT', 'AIF1-show-Alzheimer Disease', 'P2RY12-show-Alzheimer Disease', 'CORO1A-investigate-P2RY12', 'CORO1A-use-MAPT', 'P2RY12-use-MAPT', 'Alzheimer Disease-compare-AIF1', 'Alzheimer Disease-increased-AIF1', 'Alzheimer Disease-compare-P2RY12', 'Alzheimer Disease-increased-P2RY12', 'KIF1A-link-FGF5', 'rs59733750-link-rs7680591', 'Ocular Motility Disorders-investigate-CFL1', 'KIF1A-link-rs7680591', 'Alzheimer Disease-investigate-CFL1', 'rs59733750-link-FGF5', 'Ocular Motility Disorders-investigate-P2RY12', 'Alzheimer Disease-investigate-P2RY12', 'Ocular Motility Disorders-use-MAPT', 'Alzheimer Disease-use-MAPT', 'IL6-include-Inflammation', 'VWF-include-Inflammation', 'KL-link-Colonic Neoplasms', 'MTOR-link-Colonic Neoplasms', 'Neurodegenerative Diseases-related-APOE', 'Carcinogenesis-propose-KL', 'Carcinogenesis-propose-MTOR', 'Dementia-correlate-APOE', 'CHAT-used-Alzheimer Disease', 'SLC18A3-used-Alzheimer Disease', 'CHAT-preserved-Alzheimer Disease', 'SLC18A3-preserved-Alzheimer Disease', 'Alzheimer Disease-compare-APOE', 'KDM4B-control-Bone Diseases, Metabolic', 'KDM4B-present-Osteoporosis', 'KDM6B-lead-Bone Diseases, Metabolic', 'INS-be in-Obesity', 'KDM6B-present-Osteoporosis', 'CS-caused-ERCC6', 'EGF-enhance-INS', 'Corneal Diseases-enhance-INS', 'MRE11-result-CASP1', 'MRE11-result-Inflammation', 'NPTXR-identify-Alzheimer Disease', 'NEFL-warrant further investigation into-Alzheimer Disease', 'NEFL-identify-Alzheimer Disease', 'NPTXR-emerge-Alzheimer Disease', 'NEFL-emerge-Alzheimer Disease', 'SRSF1-shown-Progeria', 'SRSF6-shown-Progeria', 'rs58596362-shown-Progeria', 'INS-related-Obesity', 'NANOG-upregulated-SOX2', 'POU5F1-upregulated-SOX2', 'NANOG-upregulated-Neoplasms', 'POU5F1-upregulated-Neoplasms', 'SOX2-upregulated-Neoplasms', 'SYT9-underlie-BDNF', 'Nervous System Malformations-be in-Cockayne Syndrome', 'MAPK1-cause-Obesity', 'SYT9-downregulated-Cockayne Syndrome', 'SYT9-underlie-Nervous System Malformations', 'BDNF-downregulated-Cockayne Syndrome', 'BDNF-underlie-Nervous System Malformations', 'BDNF-neurological defects in-Cockayne Syndrome', 'BDNF-underlie-Cockayne Syndrome', 'Neuromuscular Diseases-affect-TTN', 'Neuromuscular Diseases-affect-NEB', 'GH1-prompt-INS', 'GH1-involved-INS', 'GHR-involved-INS', 'GH1-prompt-Hyperplasia', 'GH1-involved-Hyperplasia', 'GHR-involved-Hyperplasia', 'INS-involved-Hyperplasia', 'HACE1-augment-NFE2L2', 'Ghrelin-differ-LEP', 'HACE1-provide-Drug Hypersensitivity', 'Drug Hypersensitivity-augment-NFE2L2', 'Cerebral Amyloid Angiopathy-investigated-APOE', 'Cerebral Amyloid Angiopathy-investigated-PSEN1', 'Prostatic Hyperplasia-exist-FGF7', 'Prostatic Hyperplasia-exist-TGFA', 'HACE1-play role in-NFE2L2', 'Neoplasms-play role in-Neurodegenerative Diseases', 'HACE1-play role in-Neurodegenerative Diseases', 'Neoplasms-play role in-NFE2L2', 'F2RL1-lead-NLRP3', 'JUNB-accelerate-Cartilage Diseases', 'FBXO21-accelerate-Cartilage Diseases', 'Atorvastatin-reduce-ALPP', 'Atorvastatin-reduce-BGLAP', 'ALPP-induced-Osteosarcoma', 'BGLAP-induced-Osteosarcoma', 'Atorvastatin-induced-Osteosarcoma', 'SIRT1-promote tumorigenesis through-PTEN', 'SIRT1-promote tumorigenesis through-AKT1', 'SIRT1-tumorigenesis of-Carcinoma, Hepatocellular', 'SIRT1-promote-Carcinoma, Hepatocellular', 'Carcinoma, Hepatocellular-promote-PTEN', 'CD28-associated-Cytomegalovirus Infections', 'Cytomegalovirus Infections-associated-CD28', 'Carcinoma, Hepatocellular-promote-AKT1', 'CD8A-associated-Cytomegalovirus Infections', 'Cytomegalovirus Infections-associated-CD8A', 'rs909253-determined-Death', 'LRP8-mediate-RELN', 'CHEK1-mutate-CHEK2', 'Pancreatic Neoplasms-mutate-CHEK1', 'Pancreatic Neoplasms-mutate-CHEK2', 'CTTN-associated-KLK3', 'KLK3-associated-CTTN', 'CTTN-associated-Prostatic Neoplasms', 'Prostatic Neoplasms-associated-CTTN', 'Leukemia, Myeloid, Acute-demonstrate-SRC', 'Leukemia, Myeloid, Acute-demonstrate-TNF', 'SIRT1-lead-BAX', 'UMOD-identified-Albuminuria', 'UMOD-associated-Albuminuria', 'Albuminuria-associated-UMOD', 'UMOD-identified-Renal Insufficiency, Chronic', 'SHROOM3-associated-Albuminuria', 'Albuminuria-associated-SHROOM3', 'SHROOM3-identified-Albuminuria', 'SHROOM3-identified-Renal Insufficiency, Chronic', 'Fatigue-related-CRP', 'Fatigue-related-IL6', 'GRN-include-Alzheimer Disease', 'GRN-include-Dementia', 'NOTCH3-include-Alzheimer Disease', 'NOTCH3-include-Dementia', 'rs514492-be in-VCP', 'rs33949390-be in-LRRK2', 'VCP-show-Alzheimer Disease', 'Bone Diseases-associated-Renal Insufficiency, Chronic', 'Renal Insufficiency, Chronic-associated-Bone Diseases', 'Alzheimer Disease-show-LRRK2', 'Bone Diseases-understand-FGF23', 'Renal Insufficiency, Chronic-understand-FGF23', 'Bone Diseases-understand-SOST', 'rs514492-show-Alzheimer Disease', 'Renal Insufficiency, Chronic-understand-SOST', 'rs33949390-protective effect on-Alzheimer Disease', 'rs33949390-show-Alzheimer Disease', 'rs33949390-be in-Lewy Body Disease', 'Alzheimer Disease-show-rs33949390', 'FNDC5-play-INS', 'INS-contribute-FNDC5', 'FNDC5-play-Obesity', 'Obesity-contribute-FNDC5', 'FNDC5-associated-INS', 'INS-associated-FNDC5', 'rs16835198-associated-INS', 'INS-associated-rs16835198', 'rs726344-associated-INS', 'INS-associated-rs726344', 'GGH-increase-Glucose', 'Neoplasms-analysed-PGR', 'Neoplasms-analysed-ERBB2', 'HIF1A-evaluated-Hypoxia', 'SLC2A1-evaluated-Hypoxia', 'ATM-overcome-Heart Arrest', 'ATR-overcome-Heart Arrest', 'NOS1-found-NOS2', 'NOS1-show-NOS2', 'TMPRSS5-associated-ANGPTL4', 'ANGPTL4-associated-TMPRSS5', 'rs1879417-found-rs2297518', 'rs1879417-show-rs2297518', 'TMPRSS5-associated-Coronary Artery Disease', 'Coronary Artery Disease-associated-TMPRSS5', 'LDLRAD1-associated-Coronary Artery Disease', 'Coronary Artery Disease-associated-LDLRAD1', 'NOS1-found-rs2297518', 'NOS1-show-rs2297518', 'ANGPTL4-associated-Coronary Artery Disease', 'Coronary Artery Disease-associated-ANGPTL4', 'rs1879417-found-NOS2', 'rs1879417-show-NOS2', 'Glucose-affect-FGF19', 'Glucose-affect-FGF23', 'CRP-increase-Dementia', 'Glucose-affect-FGF21', 'CD4-include-Parkinson Disease', 'CD8A-include-Parkinson Disease', 'CLEC12A-identify-FLT3', 'CLEC12A-identify-Leukemia, Myeloid, Acute', 'Alzheimer Disease-determine-Atrophy', 'Alzheimer Disease-determine-Leukoencephalopathies', 'Alzheimer Disease-determine-APOE', 'Alzheimer Disease-determine-MAPT', 'Carcinoma, Non-Small-Cell Lung-harbor-EML4', 'Carcinoma, Non-Small-Cell Lung-harbor-ALK', 'Fibromyalgia-associated-LEP', 'LEP-associated-Fibromyalgia', 'CSF1R-use-Neoplasms', 'FGFR1-amplified-FGFR2', 'FGFR1-amplified-Breast Neoplasms', 'FGFR1-amplified-Stomach Neoplasms', 'FGFR2-be in-Stomach Neoplasms', 'FGFR1-be in-Myeloproliferative Disorders', 'FGFR1-be in-Neoplasms', 'Obesity-produce-CD8A', 'Memory Disorders-undergo-SORL1', 'Memory Disorders-undergo-BDNF', 'Memory Disorders-undergo-TOMM40', 'Memory Disorders-undergo-WWC1', 'Memory Disorders-undergo-COMT', 'IRF3-associated-INS', 'INS-associated-IRF3', 'IRF3-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-IRF3', 'IGFBP1-occur-IGF1', 'IGFBP3-occur-IGF1', 'IGFBP1-associated-Death', 'Death-associated-IGFBP1', 'IGFBP3-associated-Death', 'Death-associated-IGFBP3', 'rs199968569-be in-PLAA', 'Death-occur-IGF1', 'rs138487371-be in-PCDH8', 'INS-improve-Glucose Metabolism Disorders', 'CST3-affected-Inflammation', 'B2M-affected-Inflammation', 'Infections-lead-FOXO1', 'UVSSA-implicated-USP7', 'GDF5-associated-Osteoarthritis', 'Osteoarthritis-associated-GDF5', 'DIO3-associated-Osteoarthritis', 'Osteoarthritis-associated-DIO3', 'ASPN-associated-Osteoarthritis', 'Osteoarthritis-associated-ASPN', 'Cachexia-associated-TNF', 'TNF-associated-Cachexia', 'Cachexia-associated-IL6', 'IL6-associated-Cachexia', 'Cachexia-associated-IFNG', 'IFNG-associated-Cachexia', 'FKBP5-promote-Inflammation', 'Myocardial Infarction-linked-Inflammation', 'FKBP5-enhance-Myocardial Infarction', 'Breast Neoplasms-assessed-Small Cell Lung Carcinoma', 'FKBP5-mediate-Inflammation', 'FKBP5-driven-Inflammation', 'Neoplasms-be with-TSC1', 'GRK2-reverse-Heart Failure', 'S100A1-reverse-Heart Failure', 'Neoplasms-express-Lymphoma, Mantle-Cell', 'Lymphoma, Mantle-Cell-express-CD5', 'Neoplasms-express-CD5', 'Lymphoma, Mantle-Cell-express-CCND1', 'Neoplasms-express-CCND1', 'Facial Dermatoses-use-TP53', 'Facial Dermatoses-use-VDR', 'TP53-increase-VDR', 'Keratosis, Actinic-be in-Carcinogenesis', 'TP53-increase-Keratosis, Actinic', 'AKT1-involved-Disorders of Sex Development', 'TP53-increase-Carcinogenesis', 'HNF4A-decrease-Parkinson Disease', 'Disorders of Sex Development-involved-RUNX2', 'PTBP1-decrease-Parkinson Disease', 'Disorders of Sex Development-involved-SP7', 'Disorders of Sex Development-involved-IBSP', 'Disorders of Sex Development-involved-SPP1', 'RHOA-decrease-SRF', 'HNF4A-provide-INS', 'PTBP1-provide-INS', 'HNF4A-observed-Parkinson Disease', 'PTBP1-observed-Parkinson Disease', 'INS-observed-Parkinson Disease', 'Neoplasms-monitored-Viremia', 'CDKN1B-required-Glioblastoma', 'RNF123-required-Glioblastoma', 'FOXO3-demonstrate-rs1935949', 'INS-be in-Osteoporotic Fractures', 'IGF1-be in-Osteoporotic Fractures', 'von Willebrand Diseases-extend-F8', 'EIF4A2-represent-Alzheimer Disease', 'MAPT-represent-Alzheimer Disease', 'TMEM106B-influence-TARDBP', 'TMEM106B-influence-TDP-43 Proteinopathies', 'EIF4A2-reduce-MAPT', 'EIF4A2-involved-Alzheimer Disease', 'APOE-increase-GRIN2B', 'Neurotoxicity Syndromes-contribute-Neurodegenerative Diseases', 'INS-contribute-Neurotoxicity Syndromes', 'INS-contribute-Neurodegenerative Diseases', 'APOE-increase-Dementia', 'PRKAA2-contribute-Neurotoxicity Syndromes', 'Dementia-enhance-GRIN2B', 'PRKAA2-contribute-Neurodegenerative Diseases', 'Hypoxia-cause of-Alzheimer Disease', 'Ischemia-cause of-Alzheimer Disease', 'Alzheimer Disease-driven-TREM2', 'SIRT1-regulate chondrocyte activity in-Osteoarthritis', 'Osteoarthritis-regulate-RUNX2', 'SIRT1-regulate chondrocyte lineage through-RUNX2', 'Hypertrophy-regulate-Osteosarcoma', 'SIRT1-regulate-Hypertrophy', 'SIRT1-regulate-Cartilage Diseases', 'SIRT1-regulate chondrocyte lineage through-Osteosarcoma', 'SIRT1-regulate-Osteoarthritis', 'Hypertrophy-regulate-RUNX2', 'SIRT1-express-RUNX2', 'SIRT1-observed-Osteoarthritis', 'RUNX2-express-Osteoarthritis', 'BAX-implemented-Phosphatidylserines', 'ATR-modulate-WRN', 'ATM-modulate-WRN', 'ATR-modulate-Heart Arrest', 'ATM-modulate-Heart Arrest', 'WRN-modulate-Heart Arrest', 'WRN-include-RECQL4', 'Neoplasms-include-RECQL4', 'TP53-binding between-FOXO4', 'TP53-mediate-FOXO4', 'FOXO4-interact with-TP53', 'Neoplasms-collected-SIRT2', 'Neoplasms-collected-SIRT3', 'FOXO4-interact-ADAT2', 'Neoplasms-collected-SIRT4', 'Neoplasms-collected-SIRT5', 'Hypoalphalipoproteinemias-interact-ADAT2', 'Neoplasms-collected-SIRT6', 'SIRT2-reduced-Neoplasms', 'SIRT3-reduced-Neoplasms', 'Pain-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-Pain', 'Atrophy-contain-Stroke', 'Atrophy-contain-Myocardial Infarction', 'PRTN3-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-PRTN3', 'Diabetes Mellitus-include-Hyperglycemia', 'Atrophy-contain-Cardiomyopathies', 'Diabetes Mellitus-include-Microvascular Angina', 'Diabetes Mellitus-underlie-Microvascular Angina', 'Atrophy-contain-Heart Diseases', 'Diabetes Mellitus-include-MAPT', 'Diabetes Mellitus-underlie-MAPT', 'WNT1-express-Osteoporosis', 'WNT5A-express-Osteoporosis', 'WNT7A-express-Osteoporosis', 'WNT9A-express-Osteoporosis', 'FGF23-decreased-KL', 'FGF23-be elevated In-Renal Insufficiency, Chronic', 'Renal Insufficiency, Chronic-decreased-KL', 'Infections-eliminated-IL6', 'Infections-eliminated-CXCL8', 'ACE2-reduce-Inflammation', 'ACE2-reduce-Thrombosis', 'ACE2-reduce-Death', 'Parkinson Disease-co-localize-SYP', 'Adenocarcinoma, Mucinous-associated-Adenocarcinoma', 'Adenocarcinoma-associated-Adenocarcinoma, Mucinous', 'Adenocarcinoma, Mucinous-associated-MUC5AC', 'MUC5AC-associated-Adenocarcinoma, Mucinous', 'Adenocarcinoma, Mucinous-associated-MUC2', 'MUC2-associated-Adenocarcinoma, Mucinous', 'Phenylketonurias-observe-CRH', 'SIRT1-inhibit-Inflammation', 'CD8A-extend-CD4', 'rs6910534-be in-CYP19A1', 'Death-identified-FOXO1', 'Leukemia, Myeloid, Acute-show-IRF7', 'Death-identified-KL', 'Death-identified-LEPR', 'Cetuximab-target-EGFR', 'SIRT1-undergo degradation as-MAPK8', 'SIRT1-undergo-Obesity', 'Obesity-undergo-MAPK8', 'Death-identified-PON1', 'Death-identified-PSEN1', 'Death-identified-SOD2', 'Hesperidin-tested-Drug-Related Side Effects and Adverse Reactions', 'SLC13A5-accompanied-Heart Arrest', 'Heart Arrest-accompanied-CCNB1', 'rs3842755-show-rs9456497', 'rs13251813-show-rs9456497', 'MLH1-associated-Death', 'Death-associated-MLH1', 'rs10047589-associated-Death', 'Death-associated-rs10047589', 'rs207444-associated-Death', 'Death-associated-rs207444', 'rs26802-associated-Death', 'Death-associated-rs26802', 'rs13320360-associated-Death', 'Death-associated-rs13320360', 'rs2509049-associated-Death', 'Death-associated-rs2509049', 'rs705649-associated-Death', 'Death-associated-rs705649', 'PTX3-reflect-CRP', 'PTX3-reflect-Inflammation', 'FOXO3-be key downstream target of-AKT1', 'FOXO3-proposed-Neoplasms', 'INS-proposed-Neoplasms', 'MMP2-correlated-MMP9', 'MMP2-correlated-Choroiditis', 'MMP9-be in-Choroiditis', 'CDKN2AIP-cause-TP53', 'CDKN2AIP-cause-Neoplasms', 'CDKN2AIP-interact-TP53', 'CDKN2AIP-get-MDM2', 'CDKN2AIP-interact-MDM2', 'TP53-get-MDM2', 'CDKN2AIP-interact with-Acute Kidney Injury', 'Acute Kidney Injury-get-MDM2', 'Obesity-observed-Hyperuricemia', 'NRGN-predict-Alzheimer Disease', 'COX10-develop-Alzheimer Disease', 'COX15-develop-Alzheimer Disease', 'SIRT6-phosphorylated-AKT1', 'Breast Neoplasms-phosphorylated-SIRT6', 'Breast Neoplasms-find-AKT1', 'Breast Neoplasms-find-MDM2', 'SIRT6-correlate with-AKT1', 'SIRT6-correlate In-Breast Neoplasms', 'Atrial Fibrillation-show-Parkinson Disease, Secondary', 'Atrial Fibrillation-show-BAX', 'SIRT3-correlated-AFP', 'SIRT3-correlated-Neoplasms', 'ALPP-stain-SOST', 'SIRT1-regulate-INS', 'SIRT1-regulate-ADIPOQ', 'SIRT1-regulate-Inflammation', 'SIRT3-play-Glucose', 'SIRT1-represent-INS', 'SIRT1-represent-Diabetes Mellitus, Type 2', 'SIRT1-regulate-Glucose', 'SIRT6-discuss-Diabetes Mellitus, Type 2', 'OPA1-associated-Optic Atrophy, Autosomal Dominant', 'Optic Atrophy, Autosomal Dominant-associated-OPA1', 'CD8A-differ-CD4', 'Myocardial Infarction-be with-CD8A', 'Myocardial Infarction-differ-CD4', 'SORL1-associated-Alzheimer Disease', 'Alzheimer Disease-associated-SORL1', 'BIN1-associated-Alzheimer Disease', 'Alzheimer Disease-associated-BIN1', 'SIRT6-deacetylate-WRN', 'SIRT6-mutated-Werner Syndrome', 'WRN-mutated-Werner Syndrome', 'Endocrine System Diseases-include-INS', 'Endocrine System Diseases-include-MTOR', 'Endocrine System Diseases-link-MTOR', 'LRP5-lead-Osteoporosis', 'WNT1-lead-Osteoporosis', 'ACE2-converting-ACE', 'Intestinal Neoplasms-suppress-Neoplasms', 'SIRT1-suppress-Intestinal Neoplasms', 'SIRT1-suppress-Neoplasms', 'Anemia-differ-ALB', 'Anemia-differ-TF', 'Anemia-exhibit-CRP', 'Anemia-differ-Cholesterol', 'FGF21-be in-Diabetes Mellitus', 'IL9-used-Neoplasms', 'STAT3-used-Neoplasms', 'Fatty Acids-used-Neoplasms', 'Fatty Acids-regulate-Neoplasms', 'PAX3-identified-Rhabdomyosarcoma, Alveolar', 'PAX3-confirm-Rhabdomyosarcoma, Alveolar', 'FOXO1-identified-Rhabdomyosarcoma, Alveolar', 'FOXO1-confirm-Rhabdomyosarcoma, Alveolar', 'PAX7-identified-Rhabdomyosarcoma, Alveolar', 'PAX7-confirm-Rhabdomyosarcoma, Alveolar', 'LMNA-cause-Progeria', 'ZMPSTE24-cause-Progeria', 'ADIPOQ-ascertained-Death', 'CRP-ascertained-Death', 'IGF1-associated-IGFBP1', 'IGFBP1-associated-IGF1', 'IGFBP1-be relevant as-INS', 'IGF1-associated-IGFBP3', 'IGFBP3-associated-IGF1', 'IGFBP1-be relevant in-Metabolic Syndrome', 'INS-induced-GH1', 'INS-induced-Fatty Acids, Nonesterified', 'PRKAA2-increase-Osteoarthritis', 'Osteoarthritis-be deficient in-PRKAA2', 'KL-inhibition with-PAK1', 'KL-elevate-PAK1', 'KL-reverse-Carcinoma, Hepatocellular', 'PAK1-reverse-Carcinoma, Hepatocellular', 'KL-facilitate-Carcinoma, Hepatocellular', 'KDR-mediated-KL', 'KDR-block-Carcinoma, Hepatocellular', 'KL-reversed-PAK1', 'TRPV6-prevent-Calcinosis', 'KL-block-Carcinoma, Hepatocellular', 'CEACAM1-prevent-Calcinosis', 'SPP1-prevent-Calcinosis', 'LRP5-prevent-Calcinosis', 'TNFSF11-prevent-Calcinosis', 'Calcinosis-govern-CYP24A1', 'Calcinosis-govern-PTH', 'Calcinosis-govern-FGF23', 'Calcinosis-govern-PHEX', 'Calcinosis-govern-KL', 'Pigmentation Disorders-regulate-Inflammation', 'KITLG-regulate-Pigmentation Disorders', 'KITLG-regulate-Inflammation', 'HGF-regulate-Pigmentation Disorders', 'CRH-activated-Nerve Degeneration', 'POMC-activated-Nerve Degeneration', 'WRN-made-RECQL5', 'RECQL4-made-RECQL5', 'Genetic Diseases, Inborn-result-Neoplasms', 'Genetic Diseases, Inborn-made-RECQL5', 'ANGPT1-activate-TEK', 'Erectile Dysfunction-activate-TEK', 'AQP9-impair glycerol import into-CD8A', 'CALCA-decrease in-Osteoporosis', 'BGLAP-used-Osteoporosis', 'AQP9-impair-Glycerol', 'AQP9-impair glycerol import for-Fatty Acids', 'AQP9-impair-Triglycerides', 'Glycerol-impair-Fatty Acids', 'Glycerol-impair-Triglycerides', 'Drug-Related Side Effects and Adverse Reactions-suggest-Alzheimer Disease', 'MAPT-decrease-Drug-Related Side Effects and Adverse Reactions', 'Respiratory Tract Diseases-enhance-IL6', 'CRP-enhance-Respiratory Tract Diseases', 'CRP-monitor-Respiratory Tract Diseases', 'CSNK2A2-phosphorylate-TERF1', 'INS-disturb-GGH', 'Hyperinsulinism-shift-INS', 'Hyperinsulinism-disturb-GGH', 'Myocardial Infarction-influence-Inflammation', 'IRS1-identified-ADAMTSL3', 'rs2934656-identified-rs4842924', 'IRS1-identified-rs4842924', 'rs2934656-identified-ADAMTSL3', 'Inflammation-influence-TLR4', 'Inflammation-influence-IL10', 'Inflammation-influence-rs61752717', 'Inflammation-influence-rs1764391', 'Inflammation-influence-rs4986790', 'Inflammation-influence-rs1800896', 'ABCB5-show-Neoplasms', 'C16orf96-show-Neoplasms', 'ABCB5-share-C16orf96', 'Sarcoma-shown-ABCB5', 'ABCB5-share-Melanoma', 'Hypothalamic Diseases-act-GGH', 'Hypothalamic Diseases-act-GHRH', 'Hyperplasia-include-Neoplasms', 'Adenoma-include-Neoplasms', 'SHH-expressed-Hyperplasia', 'MSTN-play-Obesity', 'SHH-expressed-Adenoma', 'CRP-defined-IL6', 'Metabolic Syndrome-defined-CRP', 'Metabolic Syndrome-defined-IL6', 'Metabolic Syndrome-associated-IL6', 'IL6-associated-Metabolic Syndrome', 'Neurologic Manifestations-characterized-Heart Arrest', 'Neurologic Manifestations-involved-Inflammation', 'Neurologic Manifestations-characterized-RBL1', 'Neurologic Manifestations-characterized-BUB1B', 'Neurologic Manifestations-increase-CDKN1A', 'Polyploidy-conferred-NAMPT', 'ERBB2-include-EGFR', 'EGFR-involved-Skin Neoplasms', 'ERBB2-involved-Skin Neoplasms', 'GSTP1-analyzed-SOD3', 'GSTP1-analyzed-ESR1', 'Alzheimer Disease-include-PSEN1', 'Alzheimer Disease-include-PSEN2', 'rs2153157-show-rs4886238', 'Idiopathic Pulmonary Fibrosis-exhibit-FASLG', 'Idiopathic Pulmonary Fibrosis-exhibit-AKT1', 'SYCP2L-obtained-Ovarian Diseases', 'TDRD3-obtained-Ovarian Diseases', 'rs2153157-associated-Ovarian Diseases', 'Ovarian Diseases-associated-rs2153157', 'rs4886238-show-Ovarian Diseases', 'FSHB-affect-FSHR', 'CRP-be in-Pneumonia', 'Osteoarthritis-associated-IL1RN', 'IL1RN-associated-Osteoarthritis', 'DNMT3A-retain-Death', 'DNMT3A-exhibit-Death', 'Fractures, Bone-confer-LRP6', 'Necrosis-activate-TNFRSF12A', 'Neoplasms-activate-TNFRSF12A', 'Acute Kidney Injury-induced-Drug Overdose', 'Acute Kidney Injury-induced-Ureteral Obstruction', 'CETP-be with-Atherosclerosis', 'TNFSF12-increased-Acute Kidney Injury', 'LIPC-be with-Atherosclerosis', 'Atherosclerosis-focus-CETP', 'TNFSF12-target-Ureteral Obstruction', 'TNFRSF12A-increased-Acute Kidney Injury', 'Atherosclerosis-characterize-LIPC', 'TNFRSF12A-target-Ureteral Obstruction', 'NLRP3-inhibit-S100A9', '3-Hydroxybutyric Acid-inhibit-NLRP3', '3-Hydroxybutyric Acid-inhibit-S100A9', 'PTK2B-observed-Parkinson Disease', 'GALR2-attenuate-INS', 'KL-be anti-aging protein-KDR', 'KL-involved-KDR', 'GALR2-attenuate-Alzheimer Disease', 'KL-involved-TRPC1', 'FUS-detect-Neoplasms', 'KL-involved-Infliximab', 'XRCC1-be with-Endometriosis', 'Mitochondrial Diseases-upregulate-ATG5', 'Mitochondrial Diseases-upregulate-ATG12', 'SIRT1-blocked-PRKAB1', 'SIRT1-target-Hypoxia', 'SIRT1-target-Carcinoma, Non-Small-Cell Lung', 'SIRT1-overcome-Carcinoma, Non-Small-Cell Lung', 'PRKAB1-target-Hypoxia', 'PRKAB1-target-Carcinoma, Non-Small-Cell Lung', 'PRKAB1-overcome-Carcinoma, Non-Small-Cell Lung', 'SIRT1-regulate-PPARG', 'SIRT1-regulate-TP53', 'SIRT1-regulate-Neoplasms', 'IGFBP7-result-GPHA2', 'ACHE-develop-Alzheimer Disease', 'IGFBP7-be in-Prostatic Neoplasms', 'Prostatic Neoplasms-result-GPHA2', 'IL27-exploited-IL27RA', 'IL27-benefit-IL27RA', 'Prostatic Neoplasms-act-Neoplasms', 'Prostatic Neoplasms-bear-Neoplasms', 'IL27-exploited-Prostatic Neoplasms', 'Neoplasms-benefit-IL27', 'Prostatic Neoplasms-exploited-IL27RA', 'BACH1-increase-NFE2L2', 'rs238358-associated-AKAP11', 'AKAP11-associated-rs238358', 'rs238358-incorporate-AKAP11', 'BACH1-increase-GCLC', 'rs238358-associated-TNFSF11', 'TNFSF11-associated-rs238358', 'rs238358-incorporate-TNFSF11', 'BACH1-increase-GCLM', 'GCLC-include-NFE2L2', 'GCLM-include-NFE2L2', 'HMOX1-include-NFE2L2', 'TNFRSF11B-play role in-Vascular System Injuries', 'TNFSF11-play role in-Vascular System Injuries', 'TNFRSF11A-play role in-Vascular System Injuries', 'BACH1-increase-Sjogren-Larsson Syndrome', 'Sjogren-Larsson Syndrome-include-NFE2L2', 'NFE2L2-activated-EIF2AK3', 'ATF4-activated-EIF2AK3', 'NFE2L2-postpone-Cataract', 'ATF4-postpone-Cataract', 'Diabetes Mellitus, Type 2-show-ADIPOQ', 'Diabetes Mellitus, Type 2-show-Triglycerides', 'PLA2G4A-found-Alzheimer Disease', 'PTGS2-found-Alzheimer Disease', 'GRM7-characterized-NAT2', 'Keratitis, Dendritic-induce-ITGAE', 'GRHL2-characterized-NAT2', 'GRM7-characterized-GRHL2', 'rs11928865-characterized-rs1799930', 'rs10955255-characterized-rs1799930', 'rs13263539-characterized-rs1799930', 'Keratitis, Dendritic-induce-CD8A', 'rs1981361-characterized-rs1799930', 'rs11928865-characterized-rs13263539', 'rs11928865-characterized-rs1981361', 'rs10955255-characterized-rs13263539', 'rs10955255-characterized-rs1981361', 'rs13263539-characterized-rs1981361', 'rs11928865-characterized-NAT2', 'rs10955255-characterized-NAT2', 'rs13263539-characterized-NAT2', 'rs1981361-characterized-NAT2', 'GRM7-characterized-rs1799930', 'NFIB-over-expressing-Heart Arrest', 'GRM7-characterized-rs13263539', 'CDC25A-over-expressing-Heart Arrest', 'GRM7-characterized-rs1981361', 'GRHL2-characterized-rs1799930', 'rs11928865-characterized-GRHL2', 'rs10955255-characterized-GRHL2', 'GRHL2-characterized-rs13263539', 'GRHL2-characterized-rs1981361', 'Deafness-characterized-NAT2', 'Deafness-characterized-GRHL2', 'Deafness-characterized-rs1799930', 'Deafness-characterized-rs13263539', 'Deafness-characterized-rs1981361', 'ADNP-result in-CTNNBL1', 'Muscular Diseases-deregulated-Myalgia', 'Myalgia-result in-Muscular Diseases', 'ADNP-deregulated-Muscular Diseases', 'Myalgia-result in-ADNP', 'ADNP-result in-Muscular Diseases', 'Muscular Diseases-deregulated-CTNNBL1', 'Myalgia-result in-CTNNBL1', 'ADNP-predict-Myalgia', 'ADNP-be with-Myalgia', 'Myalgia-predict-MAPRE1', 'rs9486902-be in-FOXO3', 'Tendinopathy-associated-PTX3', 'PTX3-associated-Tendinopathy', 'Tendinopathy-associated-CXCL1', 'CXCL1-associated-Tendinopathy', 'Tendinopathy-associated-CXCL6', 'CXCL6-associated-Tendinopathy', 'Tendinopathy-associated-CXCL8', 'CXCL8-associated-Tendinopathy', 'Tendinopathy-associated-PDPN', 'PDPN-associated-Tendinopathy', 'LCN2-correlate-Arthritis, Rheumatoid', 'Fibrosis-silence-FSHR', 'AKT1-induce-SIRT1', 'AKT1-induce downregulation to-Hypoxia', 'PTH-prevent-Osteoporotic Fractures', 'Osteoporotic Fractures-prevent-SOST', 'Fatty Acids, Nonesterified-increase-SIRT1', 'Fatty Acids, Nonesterified-activate-PRKAB1', 'TOMM40-included-APOE', 'TOMM40-differentiate-APOE', 'rs10524523-included-APOE', 'rs10524523-differentiate-APOE', 'ADIPOQ-related-Glucose Metabolism Disorders', 'SLC2A4-related-Glucose Metabolism Disorders', 'Sleep Wake Disorders-involved-Neoplasms', 'Sleep Wake Disorders-involved-CLOCK', 'Sleep Wake Disorders-involved-ARNTL', 'Sleep Wake Disorders-low expression of-CRY2', 'Sleep Wake Disorders-involved-CRY2', 'Diabetes Mellitus-be with-GAD2', 'SERPINB5-upregulated-Heart Arrest', 'Death-reprogrammed-SOX2', 'Death-reprogrammed-POU5F1', 'Death-reprogrammed-KLF4', 'Heart Failure-associated-GDF15', 'GDF15-associated-Heart Failure', 'Heart Failure-associated-HAVCR1', 'HAVCR1-associated-Heart Failure', 'Heart Failure-associated-SPON1', 'SPON1-associated-Heart Failure', 'Heart Failure-associated-FST', 'FST-associated-Heart Failure', 'C9orf72-constitute mutation behind-PSEN1', 'Heart Failure-associated-TNFRSF11B', 'TNFRSF11B-associated-Heart Failure', 'C9orf72-constitute mutation behind-rs63749824', 'C9orf72-constitute mutation In-Alzheimer Disease', 'Alzheimer Disease-constitute-PSEN1', 'Alzheimer Disease-constitute-rs63749824', 'WRN-affect-Ascorbic Acid', 'RUNX3-utilized-Neoplasms', 'CADM1-utilized-Neoplasms', 'Adenomatous Polyposis Coli-include-Neoplasms', 'DCC-include-Neoplasms', 'GSTP1-include-Neoplasms', 'PTEN-include-Neoplasms', 'RUNX3-include-Neoplasms', 'CADM1-include-Neoplasms', 'AKT1-be in-Osteoarthritis', 'HEXA-implicated-Bone Neoplasms', 'HEXB-implicated-Bone Neoplasms', 'CTSK-implicated-Bone Neoplasms', 'SULF1-implicated-Bone Neoplasms', 'ADAMTS5-implicated-Bone Neoplasms', 'WRN-rescue-RAD50', 'WRN-fail-Bloom Syndrome', 'Bloom Syndrome-rescue-RAD50', 'SPP1-implicated-Bone Neoplasms', 'COL8A2-implicated-Bone Neoplasms', 'Hodgkin Disease-express-TNFRSF8', 'TNFRSF8-be in-Hodgkin Disease', 'TNFRSF8-express-Hodgkin Disease', 'GPNMB-implicated-Bone Neoplasms', 'PAX5-express-Hodgkin Disease', 'TNFAIP6-implicated-Bone Neoplasms', 'FUT4-express-Hodgkin Disease', 'BCL6-express-Hodgkin Disease', 'BCL2-express-Hodgkin Disease', 'GSTP1-include-CDKN2A', 'Acute Kidney Injury-include-CDKN2A', 'Epilepsy-investigate-REST', 'Epilepsy-investigate-BDNF', 'PTEN-involved-Kidney Diseases', 'Drug-Related Side Effects and Adverse Reactions-affected-Carotid Stenosis', 'IL6-compare-Carotid Stenosis', 'IL10-compare-Carotid Stenosis', 'SMARCA5-analyzed-Alzheimer Disease', 'ALB-important role in-Breast Neoplasms, Male', 'Chromothripsis-occur-ATM', 'Chromothripsis-occur-LIG4', 'Chromothripsis-occur-WRN', 'Chromothripsis-occur-XRCC6', 'WRN-mutate-PRKDC', 'AREG-triggered-EGFR', 'AREG-triggered-Neoplasms', 'AREG-mediated-Neoplasms', 'Neoplasms-enter-EGFR', 'Neoplasms-include-EGFR', 'Neoplasms-mediated-EGFR', 'DES-identified-Muscular Atrophy', 'MYF5-identified-Muscular Atrophy', 'MYF6-identified-Muscular Atrophy', 'MYOD1-identified-Muscular Atrophy', 'MSTN-recognized-Muscular Atrophy', 'AREG-induce-Neoplasms', 'KL-inhibit-Thyroid Neoplasms', 'KL-inhibit-Neoplasms', 'Neoplasms-be with-Colitis, Ulcerative', 'Dysplastic Nevus Syndrome-methylated-CDKN2A', 'Lysosomal Storage Diseases-caused-NPC1', 'Lysosomal Storage Diseases-caused-NPC2', 'TGFA-confer-Neurodegenerative Diseases', 'VIT-associate-INS', 'INS-associate-VIT', 'Immunologic Deficiency Syndromes-associate with-Musculoskeletal Diseases', 'Heart Failure-reduced-BAX', 'VIT-associate-Cholesterol', 'Cholesterol-associate-VIT', 'VIT-associate-Triglycerides', 'Triglycerides-associate-VIT', 'VIT-associate with-Musculoskeletal Diseases', 'Immunologic Deficiency Syndromes-associate-INS', 'INS-associate-Immunologic Deficiency Syndromes', 'INS-include-Musculoskeletal Diseases', 'Immunologic Deficiency Syndromes-associate-Cholesterol', 'Cholesterol-associate-Immunologic Deficiency Syndromes', 'Cholesterol-include-Musculoskeletal Diseases', 'Immunologic Deficiency Syndromes-associate-Triglycerides', 'Triglycerides-associate-Immunologic Deficiency Syndromes', 'Triglycerides-include-Musculoskeletal Diseases', 'PTHLH-include-GFUS', 'PTHLH-inhibit-GFUS', 'PTHLH-inhibit-ALK', 'PTHLH-include-ALK', 'PTHLH-inhibit-CIAO1', 'PTHLH-include-CIAO1', 'PTHLH-inhibit-NOTCH3', 'PTHLH-include-NOTCH3', 'PTHLH-inhibit-Chemical and Drug Induced Liver Injury', 'PTHLH-include-Chemical and Drug Induced Liver Injury', 'NOTCH3-be in-Chemical and Drug Induced Liver Injury', 'GGH-be common in-Cholesterol', 'GGH-play-Cholesterol', 'INS-compare-GH1', 'INS-of indices be-Glucose', 'INS-of indices be-Myalgia', 'Hypercholesterolemia-be common in-GGH', 'Hypercholesterolemia-play-GGH', 'Hypercholesterolemia-regulate-Cholesterol', 'MTOR-foster-Wounds and Injuries', 'SIRT1-foster-Wounds and Injuries', 'CCL2-found-CCR2', 'CCL2-blocked-CCR2', 'CCL2-accelerate-Colorectal Neoplasms', 'Colorectal Neoplasms-blocked-CCR2', 'Neoplasms-correlate-Colorectal Neoplasms', 'KL-block-CCL2', 'KL-suppress-Doxorubicin', 'KL-inhibit-CCL2', 'KL-suppress-Colorectal Neoplasms', 'IGFBP1-counter-AKT1', 'IGFBP1-correlated-Coronary Artery Disease', 'Coronary Artery Disease-counter-AKT1', 'CISD1-required-Neoplasms', 'MMP3-stimulated-Infections', 'MMP9-stimulated-Infections', 'IL1B-stimulated-Infections', 'CCN2-decreased-DNMT1', 'TOE1-exhibit-RBFOX3', 'Alzheimer Disease-exhibit-RBFOX3', 'Disease-defined-Insulin Resistance', 'SPARC-members include-CCN1', 'Disease-defined-INS', 'INS-include-Insulin Resistance', 'rs369958038-alter-PCNA', 'rs369958038-alter-LIG1', 'SPARC-involved-Myocardial Infarction', 'SPARC-involved-Cardiomegaly', 'SPARC-involved-Fibrosis', 'FTO-of Association be-Glucose', 'SPARC-involved-Myocarditis', 'SPARC-involved-Diabetic Cardiomyopathies', 'SPARC-involved-Heart Valve Diseases', 'SPP1-involved-Myocardial Infarction', 'SPP1-involved-Cardiomegaly', 'SPP1-involved-Fibrosis', 'SPP1-involved-Myocarditis', 'SPP1-involved-Diabetic Cardiomyopathies', 'ETV6-detected-Neoplasms', 'SPP1-involved-Heart Valve Diseases', 'POSTN-involved-Myocardial Infarction', 'NTRK3-detected-Neoplasms', 'POSTN-involved-Cardiomegaly', 'POSTN-involved-Fibrosis', 'POSTN-involved-Myocarditis', 'POSTN-involved-Diabetic Cardiomyopathies', 'POSTN-involved-Heart Valve Diseases', 'CCN1-involved-Myocardial Infarction', 'CCN1-include-Myocardial Infarction', 'CCN1-involved-Cardiomegaly', 'CCN1-include-Cardiomegaly', 'CCN1-involved-Fibrosis', 'CCN1-involved-Myocarditis', 'CCN1-include-Myocarditis', 'CCN1-involved-Diabetic Cardiomyopathies', 'CCN1-include-Diabetic Cardiomyopathies', 'CCN1-involved-Heart Valve Diseases', 'CCN2-involved-Myocardial Infarction', 'CCN2-involved-Cardiomegaly', 'CCN2-involved-Fibrosis', 'CCN2-involved-Myocarditis', 'CCN2-involved-Diabetic Cardiomyopathies', 'CCN2-involved-Heart Valve Diseases', 'Neoplasms-classified-Bone Marrow Failure Disorders', 'Neoplasms-associated-Myelodysplastic Syndromes', 'Myelodysplastic Syndromes-associated-Neoplasms', 'Neoplasms-associated-Leukemia, Myeloid, Acute', 'Leukemia, Myeloid, Acute-associated-Neoplasms', 'FGF23-affect-Glucose Metabolism Disorders', 'KL-affect-Glucose Metabolism Disorders', 'CD4-associated-Death', 'Death-associated-CD4', 'CD4-model-Death', 'CD8A-model-Death', 'Vascular Calcification-suppress-ENPP1', 'Vascular Calcification-suppress-ABCC6', 'FOXO3-associated-Osteoarthritis', 'Osteoarthritis-associated-FOXO3', 'RPA3-associated-Osteoarthritis', 'Osteoarthritis-associated-RPA3', 'ENPP1-serve-Vascular Calcification', 'ABCC6-serve-Vascular Calcification', 'NPM1-indicate-TET2', 'NPM1-indicate-SRSF2', 'NPM1-compare-DNMT3A', 'TET2-indicate-SRSF2', 'Vascular Calcification-caused-Immunologic Deficiency Syndromes', 'TET2-compare-DNMT3A', 'SRSF2-compare-DNMT3A', 'Leukemia, Myeloid, Acute-indicate-TET2', 'Leukemia, Myeloid, Acute-compare-DNMT3A', 'MAPT-play-Alzheimer Disease', 'BACE1-play-Alzheimer Disease', 'APOE-play-Alzheimer Disease', 'ESR1-associated-INS', 'INS-associated-ESR1', 'ESR1-associated-Cholesterol', 'Cholesterol-associated-ESR1', 'rs3798577-associated-INS', 'INS-associated-rs3798577', 'rs3798577-associated-Cholesterol', 'Cholesterol-associated-rs3798577', 'YAP1-facilitate-TAFAZZIN', 'Neoplasms-release-YAP1', 'Neoplasms-release-TAFAZZIN', 'IAPP-be in-BRAF', 'IAPP-be in-Neoplasms', 'TRH-associated-CRP', 'CRP-associated-TRH', 'TRH-associated-Inflammation', 'Inflammation-associated-TRH', 'TP53-associated-Glutathione', 'Glutathione-associated-TP53', 'GSTM1-associated-Glutathione', 'Glutathione-associated-GSTM1', 'TP53-associated-Pulmonary Disease, Chronic Obstructive', 'Pulmonary Disease, Chronic Obstructive-associated-TP53', 'GSTM1-associated-Pulmonary Disease, Chronic Obstructive', 'Pulmonary Disease, Chronic Obstructive-associated-GSTM1', 'TNF-include-Drug-Related Side Effects and Adverse Reactions', 'APOE-produced-Inflammation', 'SIRT1-associated-MAPT', 'MAPT-associated-SIRT1', 'SIRT1-associated-Alzheimer Disease', 'Alzheimer Disease-associated-SIRT1', 'Genetic Diseases, Inborn-reveal-PAX8', 'Genetic Diseases, Inborn-reveal-NKX2-5', 'RAB10-associated-Parkinson Disease', 'Parkinson Disease-associated-RAB10', 'CXCL8-associated-Death', 'Death-associated-CXCL8', 'IL10-associated-Death', 'Death-associated-IL10', 'LRRK2-associated-Parkinson Disease', 'Parkinson Disease-associated-LRRK2', 'Metabolic Diseases-used-Immunologic Deficiency Syndromes', 'SHBG-used-Metabolic Diseases', 'SHBG-used-Immunologic Deficiency Syndromes', 'SREBF1-known-NFE2L1', 'NRF1-known-NFE2L1', 'CXCL12-linked-NRGN', 'Neoplasms-stimulate program of-Tuberous Sclerosis', 'ACE2-induced-IL7', 'CXCL12-linked-CHI3L1', 'Tuberous Sclerosis-known-NFE2L1', 'CXCL12-shown-Alzheimer Disease', 'Ascorbic Acid-block-ACE2', 'Neoplasms-known-NFE2L1', 'NRGN-shown-Alzheimer Disease', 'CXCR4-play-Alzheimer Disease', 'Alzheimer Disease-express-CXCR4', 'CXCL12-play-Alzheimer Disease', 'Alzheimer Disease-express-CHI3L1', 'Alzheimer Disease-express-CXCL12', 'Alzheimer Disease-express-NRGN', 'Progeria-stood-ITPR1', 'Progeria-stood-ITPR3', 'Progeria-stood-CACNA2D1', 'Progeria-stood-CAMK2N1', 'SIRT6-promote angiogenesis under-Hypoxia', 'Vascular Calcification-be in-Diabetes Mellitus', 'TNFSF11-involve-Vascular Calcification', 'TNFSF11-involve-Diabetes Mellitus', 'TNFRSF11B-involve-Vascular Calcification', 'TNFRSF11B-involve-Diabetes Mellitus', 'TNFSF11-target-AGER', 'Diabetes Mellitus-include-TNFSF11', 'Diabetes Mellitus-target-TNFSF11', 'Cardiovascular Diseases-be in-Diabetes Mellitus', 'Neoplasms-demonstrated-ALB', 'Diabetes Mellitus-include-AGER', 'Diabetes Mellitus-target-AGER', 'TNFSF11-alter-Cardiovascular Diseases', 'Glucose-include-Diabetes Mellitus', 'TNFSF11-alter-Diabetes Mellitus', 'TNFRSF11B-alter-Cardiovascular Diseases', 'TNFRSF11B-alter-Diabetes Mellitus', 'AGER-alter-Cardiovascular Diseases', 'AGER-alter-Diabetes Mellitus', 'INS-use-Glucose', 'CDKN2A-repress-HNRNPD', 'BMP2-differ-Osteoarthritis', 'SMAD6-differ between-Osteoarthritis', 'ID1-lead-BMP2', 'ID1-be lower compare-Osteoarthritis', 'ID1-be lower in-Osteoarthritis', 'ID1-derived-Osteoarthritis', 'Osteoarthritis-lead-BMP2', 'BBC3-upregulated-Osteoarthritis', 'Idiopathic Pulmonary Fibrosis-demonstrate-NFE2L2', 'Lung Diseases-demonstrate-NFE2L2', 'EGLN3-compare-EGLN2', 'EGLN3-find-EGLN2', 'EGLN3-compare-EGLN1', 'EGLN3-find-EGLN1', 'Sphingolipids-elevate-Palmitic Acid', 'Ischemia-compare-EGLN2', 'CERS5-elevate-Sphingolipids', 'Hypoxia-compare-EGLN2', 'CERS5-elevate-Palmitic Acid', 'CERS5-increase-Palmitic Acid', 'Sphingolipids-elevate-CERS4', 'Ischemia-compare-EGLN1', 'Palmitic Acid-elevate-CERS4', 'Hypoxia-compare-EGLN1', 'Meibomian Gland Dysfunction-show-IGFBP3', 'Meibomian Gland Dysfunction-show-CLU', 'MYC-respond-INS', 'MYC-induced-Glucose', 'Glucose-respond-INS', 'Neoplasms-implicated-TERF1', 'Neoplasms-implicated-TERF2', 'Neoplasms-implicated-TERF2IP', 'Neoplasms-implicated-TINF2', 'Neoplasms-implicated-TNKS', 'Neoplasms-implicated-PINX1', 'INS-be in-Diabetes Mellitus', 'CRP-measure of-Inflammation', 'Stomach Diseases-studied-GSTP1', 'Stomach Diseases-studied-THBS1', 'Stomach Diseases-studied-TIMP3', 'Eicosapentaenoic Acid-inhibit-MAPK1', 'Eicosapentaenoic Acid-inhibit-MAPK8', 'Eicosapentaenoic Acid-inhibit-MAP2K1', 'CD8A-be lower in-Carcinoma, Non-Small-Cell Lung', 'GJB1-respond-Ischemia', 'GJA1-respond-Ischemia', 'GJB1-increased-Ischemia', 'GJC1-respond-Ischemia', 'TP53-investigated-Stomach Neoplasms', 'GJC1-increased-Ischemia', 'WRN-investigated-Stomach Neoplasms', 'Death-related-NFKB1', 'Osteoarthritis-activate-NLRP3', 'NLRP3-found-Osteoarthritis', 'NFE2L2-found-Osteoarthritis', 'NLRP3-upregulated-Osteoarthritis', 'NFE2L2-upregulated-Osteoarthritis', 'SOD2-induce-Glutathione', 'SOD2-restore-Glutathione', 'TP53-induce-Glutathione', 'TP53-restore-Glutathione', 'Fatty Acids-produce-TNF', 'TERF2-induce-Glutathione', 'TERF2-restore-Glutathione', 'WFS1-involve-CISD2', 'Wolfram Syndrome-involve-CISD2', 'Acute Coronary Syndrome-associated-CD4', 'CD4-associated-Acute Coronary Syndrome', 'Acute Coronary Syndrome-associated-CD8A', 'CD8A-associated-Acute Coronary Syndrome', 'MFGE8-enhanced-Amyloidosis', 'APOE-enhanced-Amyloidosis', 'Thrombosis-result-Thrombocytopenia', 'Stroke-result-Thrombocytopenia', 'Autoimmune Diseases-result-Thrombocytopenia', 'GP6-involved-Thrombosis', 'GP6-initiate-Thrombosis', 'GP6-involved-Stroke', 'GP6-involved-Autoimmune Diseases', 'GP6-initiate-Autoimmune Diseases', 'GP1BA-associated-Thrombosis', 'Thrombosis-associated-GP1BA', 'GP6-involved-Thrombocytopenia', 'GP6-initiate-Thrombocytopenia', 'GP6-associated-Thrombosis', 'Thrombosis-associated-GP6', 'GP1BA-involved-Thrombosis', 'GP1BA-involved-Stroke', 'GP1BA-involved-Autoimmune Diseases', 'GP1BA-involved-Thrombocytopenia', 'GP1BA-initiate-Thrombocytopenia', 'Myelodysplastic Syndromes-acquire-CRAT', 'Myelodysplastic Syndromes-acquire-SLC22A5', 'Aneurysm-consider-LEP', 'Aneurysm-consider-ADIPOQ', 'Aneurysm-consider-Triglycerides', 'TF-perturbed-Parkinson Disease', 'Aneurysm-consider-Cholesterol', 'TFR2-perturbed-Parkinson Disease', 'Kidney Failure, Chronic-occur in-PKD2', 'BCL6-show-Lymphoma', 'MYC-show-Lymphoma', 'SOX11-be useful in-CCND1', 'SOX11-be useful in-Lymphoma, Mantle-Cell', 'SOX11-differentiate-Lymphoma, Mantle-Cell', 'CCND1-differentiate-Lymphoma, Mantle-Cell', 'TP53-be in-Melanoma', 'TP53-associated-Melanoma', 'Melanoma-associated-TP53', 'Muscular Atrophy, Spinal-linked-SMN1', 'Motor Neuron Disease-linked-SMN1', 'SMN1-lack-SMN2', 'Muscular Atrophy, Spinal-lack-SMN1', 'ADH1B-performed-Esophageal Squamous Cell Carcinoma', 'Cardiovascular Diseases-present-KL', 'ALDH2-performed-Esophageal Squamous Cell Carcinoma', 'Cardiovascular Diseases-present-DNMT1', 'Cardiovascular Diseases-present-DNMT3A', 'TOR1A-restore-SOD1', 'ADH1B-confer-Neoplasms', 'ALDH2-confer-Neoplasms', 'ADH1B-determine-Esophageal Squamous Cell Carcinoma', 'ALDH2-determine-Esophageal Squamous Cell Carcinoma', 'Kidney Failure, Chronic-exhibit-Kidney Diseases', 'Kidney Failure, Chronic-become-Inflammation', 'Cytomegalovirus Infections-exhibit-Kidney Diseases', 'AR-used-KLK3', 'CD4-include-Kidney Diseases', 'NPY-label-Muscular Dystrophies', 'Prostatic Neoplasms-contain-AR', 'Prostatic Neoplasms-used-AR', 'Prostatic Neoplasms-used-KLK3', 'CD8A-include-Kidney Diseases', 'INS-contribute-GGH', 'INS-remain-Glucose', 'Albuminuria-associate-Cardiovascular Diseases', 'Cardiovascular Diseases-associate-Albuminuria', 'CRP-associate with-Albuminuria', 'CRP-remain-Albuminuria', 'SH2D1A-remain-Albuminuria', 'SH2D1A-associate-Albuminuria', 'Albuminuria-associate-SH2D1A', 'SH2D1A-associate-Cardiovascular Diseases', 'Cardiovascular Diseases-associate-SH2D1A', 'APOE-interact dysfunction with-MAPT', 'APOE-interact-Glucose Metabolism Disorders', 'CDKN2A-target-SMAD4', 'TP53-target-SMAD4', 'Metabolic Syndrome-lowered-ADIPOQ', 'Metabolic Syndrome-increase-INS', 'Prostatic Hyperplasia-induce-FGF2', 'NFE2L2-be in-Neoplasms', 'LEP-be in-LEPR', 'Obesity-changes in-LEP', 'Obesity-develop-LEP', 'Hypertension-contain-NOX1', 'Hypertension-contain-CYBB', 'GLO1-reduce-NOS3', 'CRP-investigated-Inflammation', 'IL5-investigated-Inflammation', 'IL17A-investigated-Inflammation', 'LMNA-control-INS', 'Lipodystrophy, Familial Partial-caused-LMNA', 'LMNA-control-Atherosclerosis', 'Lipodystrophy, Familial Partial-associated-INS', 'INS-associated-Lipodystrophy, Familial Partial', 'Lipoma-indicated-LEP', 'Lipoma-associated-LEP', 'LEP-associated-Lipoma', 'Infections-play-MME', 'Lipoma-associated-ADIPOQ', 'ADIPOQ-associated-Lipoma', 'LGI1-associated-Sleep Wake Disorders', 'Sleep Wake Disorders-associated-LGI1', 'Sleep Wake Disorders-associated-IGLON5', 'IGLON5-associated-Sleep Wake Disorders', 'Sleep Wake Disorders-associated-CNTNAP2', 'CNTNAP2-associated-Sleep Wake Disorders', 'FOS-be higher in-Melanoma', 'Muscle Rigidity-associated-DPP6', 'DPP6-associated-Muscle Rigidity', 'Alzheimer Disease-consider-Metabolic Diseases', 'Alzheimer Disease-suggest-INS', 'Metabolic Diseases-suggest-INS', 'Alzheimer Disease-suggest-ADIPOQ', 'Metabolic Diseases-suggest-ADIPOQ', 'AR-cause-HMMR', 'CCL2-analyzed-Cholesterol', 'CX3CR1-analyzed-Cholesterol', 'VEGFA-analyzed-Cholesterol', 'Malformations of Cortical Development, Group II-associated-CXCR4', 'CXCR4-associated-Malformations of Cortical Development, Group II', 'Malformations of Cortical Development, Group II-observed-CXCR4', 'Malformations of Cortical Development, Group II-associated-ACKR3', 'ACKR3-associated-Malformations of Cortical Development, Group II', 'Malformations of Cortical Development, Group II-determined-ACKR3', 'INSR-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-INSR', 'SORT1-associated-GRN', 'GRN-associated-SORT1', 'rs5848-associated-GRN', 'GRN-associated-rs5848', 'rs646776-associated-GRN', 'GRN-associated-rs646776', 'Rothmund-Thomson Syndrome-characterized-Neoplasms', 'WRN-characterized-Neoplasms', 'Amyloidosis-include-TTR', 'SLC5A2-administered-INS', 'Glucose-administered-SLC5A2', 'INS-include-Glucose', 'SLC5A2-administered-Diabetes Mellitus, Type 2', 'Diabetes Mellitus, Type 2-include-Glucose', 'SLC5A2-be useful addition to-Diabetes Mellitus, Type 2', 'Bone Diseases-cause-Atrophy', 'Chronic Kidney Disease-Mineral and Bone Disorder-cause-Atrophy', 'PTH-cause-Atrophy', 'FGF23-cause-Atrophy', 'Neurodegenerative Diseases-modulate-Amyloidosis', 'APOE-risk for-Neurodegenerative Diseases', 'APOE-modulate-Neurodegenerative Diseases', 'APOE-modulate-Amyloidosis', 'MAPT-modulate-Neurodegenerative Diseases', 'Glucose-explore-SIRT1', 'Glucose-explore-MAPK8', 'Glucose-explore-NAMPT', 'Glucose-reduce-SIRT1', 'Palmitates-reduce-SIRT1', 'Fatty Acids-explore-SIRT1', 'Fatty Acids-explore-MAPK8', 'Fatty Acids-explore-NAMPT', 'MET-enhance-STAT3', 'HGF-enhance-STAT3', 'Leukemia, Lymphoid-express-MET', 'Leukemia, Lymphoid-express-HGF', 'Leukemia, Lymphoid-enhance-STAT3', 'Neoplasms-of risk be-Bloom Syndrome', 'RECQL-linked-Neoplasms', 'WRN-linked-Neoplasms', 'RECQL4-linked-Neoplasms', 'NUAK1-suffer-Aneuploidy', 'Aneuploidy-show-LATS1', 'SIRT1-reduce-TP53', 'CCL5-associated-Parkinson Disease', 'Parkinson Disease-associated-CCL5', 'CCR5-associated-Parkinson Disease', 'Parkinson Disease-associated-CCR5', 'rs1799864-associated-Parkinson Disease', 'Parkinson Disease-associated-rs1799864', 'AKT1-be of-Neurodegenerative Diseases', 'MTOR-be of-Neurodegenerative Diseases', 'SIRT1-identify-CD8A', 'FOXO1-identify-CD8A', 'INS-highlight-Diabetes Mellitus', 'SIRT1-identify-Metabolic Diseases', 'FOXO1-identify-Metabolic Diseases', 'SERPINE1-go-INS', 'INS-include-Obesity', 'Werner Syndrome-be with-WRN', 'Werner Syndrome-be with-LMNA', 'INS-preserve-Alzheimer Disease', 'Alzheimer Disease-understand-IGF1', 'IGF1-increase-IGF1R', 'IGF1-be in-Alzheimer Disease', 'IGF1R-increase-Alzheimer Disease', 'TP53-regulated-MDM2', 'Neoplasms-regulated-MDM2', 'CCL5-mediate-MAPK8', 'CCL5-elevate-Osteosarcoma', 'MAPK8-elevate-Osteosarcoma', 'CCL5-reduce-Atherosclerosis', 'SIRT1-exert-SNAI1', 'SIRT1-exert-Colorectal Neoplasms', 'SIRT1-lead-DLL4', 'SIRT1-lead-TBX3', 'SIRT1-lead-PAX6', 'APCS-remain-CRP', 'SIRT1-lead-Retinitis', 'Cardiovascular Diseases-remain-APCS', 'TP53-formulated-Carcinoma, Hepatocellular', 'PROM1-formulated-Carcinoma, Hepatocellular', 'VIP-induce-SCT', 'Neoplasms-harbor-EGFR', 'VIP-elicit-Headache', 'Neoplasms-known-EGFR', 'Neoplasms-known-ALK', 'Headache-induce-SCT', 'Carcinoma, Non-Small-Cell Lung-report-Neoplasm Metastasis', 'Carcinoma, Non-Small-Cell Lung-treat-EGFR', 'Carcinoma, Non-Small-Cell Lung-treat-ALK', 'FYN-inhibitory activity against-DYRK1A', 'FYN-show-DYRK1A', 'FYN-inhibitory activity against-Alzheimer Disease', 'DYRK1A-target in-Alzheimer Disease', 'Alzheimer Disease-enhance-GH1', 'Alzheimer Disease-enhance-GHRH', 'GH1-releasing stimulation tests to-GHRH', 'GH1-releasing stimulation tests to-Alzheimer Disease', 'GH1-be in-Alzheimer Disease', 'GHRH-be in-Alzheimer Disease', 'PSEN1-exhibit-Cholesterol', 'BACE1-exhibit-Cholesterol', 'H2AX-of phosphorylation be-TP53', 'Necrosis-contribute-IRF1', 'Necrosis-contribute-ACOD1', 'Atrophy-predict-Alzheimer Disease', 'NEFL-predict-Atrophy', 'Atrophy-predict-MAPT', 'SHBG-fall-INS', 'SHBG-fall-Hyperinsulinism', 'INS-fall-Hyperinsulinism', 'CAT-restore-ESR1', 'rs2075555-be in-COL1A1', 'rs9594738-be in-TNFSF11', 'rs4870044-be in-ESR1', 'Tramadol-decrease-CRP', 'Erectile Dysfunction-occur-Nerve Degeneration', 'Erectile Dysfunction-assumed-DYNLL1', 'Erectile Dysfunction-assumed-NOS2', 'LEP-constitute-ADIPOQ', 'LEP-constitute-INS', 'Pulmonary Disease, Chronic Obstructive-be with-LEP', 'NCOR2-associate-ADIPOQ', 'ADIPOQ-associate-NCOR2', 'Pulmonary Disease, Chronic Obstructive-be with-ADIPOQ', 'Pulmonary Disease, Chronic Obstructive-constitute-ADIPOQ', 'Pulmonary Disease, Chronic Obstructive-constitute-INS', 'NCOR2-associate-Diabetes Mellitus', 'Diabetes Mellitus-associate-NCOR2', 'NCOR2-found-Diabetes Mellitus', 'SIRT6-regulator of-COL1A1', 'COL1A1-repress-SIRT6', 'AVP-increase-AVPR2', 'INSR-develop-Glucose', 'INS-develop-Glucose', 'INSR-develop-Glucose Intolerance', 'INSR-develop-Diabetes Mellitus', 'INS-develop-Diabetes Mellitus', 'BECN1-exert-BCL2L11', 'Drug-Related Side Effects and Adverse Reactions-exert-BECN1', 'Drug-Related Side Effects and Adverse Reactions-exert-BCL2L11', 'EPHA1-result-Infections', 'EPHA1-result-Nerve Degeneration', 'EPHA1-result-Inflammation', 'IL6-associated-Hypertension', 'Hypertension-associated-IL6', 'KLRK1-associated-MICA', 'MICA-associated-KLRK1', 'KLRK1-associated-Multiple Myeloma', 'Multiple Myeloma-associated-KLRK1', 'Multiple Myeloma-display-MICA', 'Multiple Myeloma-increased-PDIA6', 'PPM1D-promote-TP53', 'PPM1D-promote-Neoplasms', 'Parkinson Disease, Secondary-include-Mitochondrial Diseases', 'MAPT-be glycate in-Alzheimer Disease', 'Alzheimer Disease-glycate-LYZ', 'SIRT5-represent-Mitochondrial Diseases', 'SIRT5-represent-Parkinson Disease, Secondary', 'Neoplasms-observed-PRL', 'PRL-reveal-Neoplasms', 'WRN-result-Genetic Diseases, Inborn', 'WRN-result-Neoplasms', 'RECQL4-result-Genetic Diseases, Inborn', 'RECQL4-result-Neoplasms', 'RECQL4-characterized-Neoplasms', 'RECQL5-result-Genetic Diseases, Inborn', 'RECQL5-result-Neoplasms', 'RECQL5-characterized-Neoplasms', 'CD4-identical transcriptome to-CD8A', 'CD4-exhibit heterogeneity in-Drug-Related Side Effects and Adverse Reactions', 'INS-associated-CRP', 'CRP-associated-INS', 'Necrosis-measured-Lipopolysaccharides', 'Osteogenesis Imperfecta-increase-RUNX2', 'Osteogenesis Imperfecta-downregulate-PPARG', 'ADIPOQ-circulate-Ceramides', 'FGF21-circulate-Ceramides', 'STAT1-underlie-Inflammation', 'C1QTNF9-inhibit senescence through-PRKAB1', 'C1QTNF9-recover-PRKAB1', 'C1QTNF9-inhibit-Palmitic Acid', 'Kidney Diseases-generate-MTRR', 'Kidney Diseases-generate-MSRA', 'Kidney Diseases-generate-MSRB1', 'Arthritis, Rheumatoid-correlated-CP', 'IL5-induced-AKT1', 'IL5-suggest-AKT1', 'IL5-promote-Neoplasms', 'Neoplasms-suggest-AKT1', 'DDIT4-represent-MTOR', 'DDIT4-represent-Osteoarthritis', 'DDIT4-observed-Osteoarthritis', 'Gastrointestinal Stromal Tumors-drive-Myofibroma', 'MTOR-observed-Osteoarthritis', 'Polyps-drive-Myofibroma', 'Glioma-drive-Myofibroma', 'PDGFRA-found-Gastrointestinal Stromal Tumors', 'PDGFRA-found-Polyps', 'PDGFRA-drive-Glioma', 'PDGFRA-drive-Myofibroma', 'S100A1-include-Brain Injuries', 'Gastrointestinal Stromal Tumors-found-PDGFRB', 'ENO2-include-Brain Injuries', 'Polyps-found-PDGFRB', 'Glioma-drive-PDGFRB', 'PDGFRB-drive-Myofibroma', 'Neoplasms-target-STAT3', 'STAT3-deregulated-Neoplasms', 'EGFR-survival in-Colorectal Neoplasms', 'Neoplasms-be with-EML4', 'Neoplasms-be with-ALK', 'AKT1S1-correlate-MAPT', 'SIRT6-identify-ACLY', 'SIRT6-identify-Neoplasms', 'Neoplasms-promote-Neoplasm Invasiveness', 'SIRT6-promote-Neoplasm Invasiveness', 'ACLY-promote-Neoplasm Invasiveness', 'ECE1-carry-APOE', 'SIRT1-lead-Colorectal Neoplasms', 'IL10-associated-Sarcopenia', 'Sarcopenia-associated-IL10', 'Adalimumab-receive-Psoriasis', 'SIRT1-increased-SOST', 'SIRT1-increased-Osteoarthritis', 'SOST-increased-Osteoarthritis', 'SOST-compare-Osteoarthritis', 'rs1800795-associated-IL6', 'IL6-associated-rs1800795', 'SHMT1-catalyzed-MTHFR', 'SHMT1-affect-Cardiovascular Diseases', 'Cardiovascular Diseases-affect-MTHFR', 'MTHFR-vary-SHMT1', 'rs1801133-vary-rs1979277', 'MTHFR-vary-rs1979277', 'rs1801133-vary-SHMT1', 'Cardiovascular Diseases-vary-SHMT1', 'Cardiovascular Diseases-vary-rs1979277', 'RHOA-express-RUNX2', 'RHOA-express-LEP', 'RHOA-express-Glucose', 'CYBB-lead-DUOX2', 'Lead Poisoning-present-Congenital Hypothyroidism', 'Kidney Failure, Chronic-show-CD4', 'CYBB-lead-Congenital Hypothyroidism', 'CYBB-present-Congenital Hypothyroidism', 'DUOX2-present as-Congenital Hypothyroidism', 'Arthritis, Rheumatoid-examined-XRCC1', 'Arthritis, Rheumatoid-examined-XRCC4', 'Arthritis, Rheumatoid-examined-rs25487', 'XRCC1-associated-Arthritis, Rheumatoid', 'Arthritis, Rheumatoid-associated-XRCC1', 'XRCC4-associated-Arthritis, Rheumatoid', 'Arthritis, Rheumatoid-associated-XRCC4', 'AQP5-entail-AQP4', 'AQP5-entail-Hearing Loss, Central', 'AQP5-entail-Meniere Disease', 'SIRT1-regulate-NOS3', 'SIRT1-involved-Cardiovascular Diseases', 'NOS3-regulate-Cardiovascular Diseases', 'Inflammation-associated-Pain', 'Pain-associated-Inflammation', 'CCL11-associated-Pain', 'Pain-associated-CCL11', 'IL7-associated-Pain', 'Pain-associated-IL7', 'CXCL8-associated-Pain', 'Pain-associated-CXCL8', 'IL13-associated-Pain', 'Pain-associated-IL13', 'IL16-associated-Pain', 'Pain-associated-IL16', 'CXCL10-associated-Pain', 'Pain-associated-CXCL10', 'CCL17-associated-Pain', 'Pain-associated-CCL17', 'Alzheimer Disease-increase-MAOA', 'Dyskinesia, Drug-Induced-result-DRD1', 'Dyskinesia, Drug-Induced-result-DRD2', 'Dyskinesia, Drug-Induced-cause-DRD2', 'ALK-be in-Adenocarcinoma of Lung', 'Alzheimer Disease-caused-PSEN1', 'Alzheimer Disease-caused-PSEN2', 'Cardiomyopathy, Dilated-evaluated-PSEN1', 'Cardiomyopathy, Dilated-evaluated-PSEN2', 'Cardiomyopathy, Dilated-implicate-Cardiomyopathies', 'Heart Failure-implicate-Cardiomyopathies', 'PSEN1-associated-Cardiomyopathy, Dilated', 'Cardiomyopathy, Dilated-associated-PSEN1', 'Cardiovascular Diseases-induce-NKX2-5', 'INS-accompanied-Hyperinsulinism', 'PSEN1-associated-Heart Failure', 'Heart Failure-associated-PSEN1', 'Cardiovascular Diseases-induce-GATA4', 'PSEN1-implicate-Cardiomyopathies', 'PSEN2-associated-Cardiomyopathy, Dilated', 'Cardiomyopathy, Dilated-associated-PSEN2', 'PSEN2-associated-Heart Failure', 'Heart Failure-associated-PSEN2', 'PSEN2-implicate-Cardiomyopathies', 'PPIB-inhibit-BAX', 'ENC1-alter-UNC5C', 'PPIB-attenuate-Mitochondrial Diseases', 'PPIB-decrease-SOD2', 'PPIB-prevent-CAT', 'CAMSAP3-delayed-CCND1', 'Neoplasms-delayed-CAMSAP3', 'Cardiovascular Diseases-mediated-DKK1', 'Cardiovascular Diseases-caused-DKK1', 'CXCL10-known-Alzheimer Disease', 'Neoplasms-delayed-CCND1', 'HIV Infections-observed-Arbovirus Infections', 'CD4-live-HIV Infections', 'CD4-observed-Arbovirus Infections', 'HIV Infections-live-TERF2', 'TERF2-observed-Arbovirus Infections', 'DANCR-decrease-RUNX2', 'DANCR-decrease-BGLAP', 'DANCR-decrease-SP7', 'Aging, Premature-caused-Cockayne Syndrome', 'Cockayne Syndrome-caused-ERCC8', 'PTEN-caused-STK11', 'Hamartoma Syndrome, Multiple-caused-STK11', 'Aging, Premature-caused-ERCC8', 'Cockayne Syndrome-caused-ERCC6', 'Aging, Premature-caused-ERCC6', 'BDNF-use-Neuroblastoma', 'ARC-use-Neuroblastoma', 'ADIPOQ-associate-INS', 'INS-associate-ADIPOQ', 'ADIPOQ-associate-Obesity', 'Obesity-associate-ADIPOQ', 'ADIPOQ-associate-Cardiovascular Diseases', 'Cardiovascular Diseases-associate-ADIPOQ', 'ADIPOQ-act-Cardiovascular Diseases', 'TNFRSF11B-include-Calcinosis', 'BGLAP-include-Calcinosis', 'SPP1-include-Calcinosis', 'SOST-include-Calcinosis', 'CA2-include-Calcinosis', 'Infliximab-inhibit-IGF1', 'Infliximab-inhibit-INS', 'Obesity-lead-Diabetes Mellitus, Type 2', 'Calcitriol-activate-VDR', 'Calcitriol-activate-KL', 'Obesity-lead-INS', 'Obesity-lead-LEP', 'Obesity-lead-Fatty Acids, Nonesterified', 'HIV Infections-associated-AMH', 'AMH-associated-HIV Infections', 'CD4-control-AMH', 'CD4-control-HIV Infections', 'PRKAA2-reverse-Urinary Bladder Neoplasms', 'Genetic Diseases, Inborn-induce-Carcinogenesis', 'BLM-associated-Genetic Diseases, Inborn', 'Genetic Diseases, Inborn-associated-BLM', 'NUP62-induce-Urinary Bladder Neoplasms', 'MAP1LC3A-induce-Urinary Bladder Neoplasms', 'Breast Neoplasms-target-ERBB2', 'Breast Neoplasms-target-VEGFA', 'AR-include-Neoplasms', 'CDKN1A-include-Neoplasms', 'SIRT1-include-Neoplasms', 'HDAC3-include-Neoplasms', 'CD4-of counts be-Memory Disorders', 'CD4-play-Infections', 'CD8A-play-Infections', 'Anemia, Aplastic-associated-Hematologic Neoplasms', 'Hematologic Neoplasms-associated-Anemia, Aplastic', 'Genetic Diseases, Inborn-caused-ERCC8', 'Genetic Diseases, Inborn-caused-ERCC6', 'INS-explain-Diabetes Mellitus', 'CRP-identify-Sepsis', 'MTOR-shown-Pulmonary Disease, Chronic Obstructive', 'KL-shown-Pulmonary Disease, Chronic Obstructive', 'GHRH-restore-GH1', 'GHRH-restore-Triglycerides', 'Neuroblastoma-depleted-ATG5', 'Neuroblastoma-depleted-RAB27A', 'MIR34A-associated-SIRT1', 'SIRT1-associated-MIR34A', 'MIR34C-associated-SIRT1', 'SIRT1-associated-MIR34C', 'MIR34A-associated-JAG1', 'JAG1-associated-MIR34A', 'MIR34C-associated-JAG1', 'JAG1-associated-MIR34C', 'MIR34A-associated-NOTCH2', 'NOTCH2-associated-MIR34A', 'MIR34C-associated-NOTCH2', 'NOTCH2-associated-MIR34C', 'MIR34A-associated-CTNNB1', 'CTNNB1-associated-MIR34A', 'MIR34C-associated-CTNNB1', 'CTNNB1-associated-MIR34C', 'MIR34A-associated-ATF1', 'ATF1-associated-MIR34A', 'MIR34C-associated-ATF1', 'ATF1-associated-MIR34C', 'LGR5-increased-Colorectal Neoplasms', 'CLOCK-upregulated-Prostatic Neoplasms', 'PER2-upregulated-Prostatic Neoplasms', 'ARNTL-upregulated-Prostatic Neoplasms', 'Neoplasms-express-KRT7', 'Lipid Metabolism Disorders-impacted-Cardiovascular Diseases', 'Lipid Metabolism Disorders-linked-GCKR', 'GCKR-impacted-Cardiovascular Diseases', 'KL-be in-Neoplasms', 'Lipid Metabolism Disorders-linked-PNPLA3', 'PNPLA3-impacted-Cardiovascular Diseases', 'TAC1-improve-ACE', 'Deglutition Disorders-elevate-Dementia', 'ADAMTS5-reverse-SPG11', 'Deglutition Disorders-elevate-TAC1', 'TAC1-elevate-Dementia', 'Deglutition Disorders-improve-ACE', 'Dementia-improve-ACE', 'ADAMTS5-inhibition in-Osteoarthritis', 'ADAMTS5-reverse-Osteoarthritis', 'Infections-show-Memory Disorders', 'Infections-show-CD4', 'NBN-be part of-MRE11', 'NBN-mutated-MRE11', 'NBN-mutated-RAD50', 'NBN-mutated-Nijmegen Breakage Syndrome', 'Nijmegen Breakage Syndrome-mutated-MRE11', 'Nijmegen Breakage Syndrome-mutated-RAD50', 'TMEM37-describe-Breast Neoplasms', 'ERBB2-describe-Breast Neoplasms', 'Coronary Artery Disease-increase-Diabetes Mellitus', 'Coronary Artery Disease-increase-SESN2', 'Obesity-increase-SESN2', 'Diabetes Mellitus-increase-SESN2', 'Atrophy-assess-TMEM106B', 'Coronary Artery Disease-increase-SESN3', 'Atrophy-assess-ABCC9', 'Diabetes Mellitus-increase-SESN3', 'Spinal Cord Injuries-regulation of-VEGFA', 'VEGFA-play-Spinal Cord Injuries', 'PRKAA2-be high Despite-ADIPOQ', 'PRKAA2-be high in-Obesity', 'Diabetes Mellitus-be with-Renal Insufficiency', 'ALB-levels of be-Coronary Artery Disease', 'ACE2-depleted-Hyperoxia', 'TMPRSS2-depleted-Hyperoxia', 'SIRT6-protective effects against-Pulmonary Disease, Chronic Obstructive', 'Alzheimer Disease-associated-IL10', 'IL10-associated-Alzheimer Disease', 'Alzheimer Disease-associated-DBH', 'DBH-associated-Alzheimer Disease', 'SIRT1-shown-SIRT6', 'SIRT1-improve-Pulmonary Disease, Chronic Obstructive', 'SIRT1-describe-Pulmonary Disease, Chronic Obstructive', 'SIRT6-describe-Pulmonary Disease, Chronic Obstructive', 'SIRT6-improve-Pulmonary Disease, Chronic Obstructive', 'SIRT6-shown-Pulmonary Disease, Chronic Obstructive', 'Muscular Atrophy-result-Cyclosporine', 'Stomach Neoplasms-be with-Microsatellite Instability', 'ITLN1-additional adjustment for-ADIPOQ', 'ITLN1-correlated-ADIPOQ', 'ITLN1-correlated-Necrosis', 'Parkinson Disease-associated-CCND3', 'CCND3-associated-Parkinson Disease', 'Parkinson Disease-associated-CDK6', 'CDK6-associated-Parkinson Disease', 'CCND3-found-Parkinson Disease', 'CDK6-found-Parkinson Disease', 'Glucose-divided-CRP', 'Glucose-accord-CRP', 'Glucose Metabolism Disorders-calculate-PRL', 'MFN2-protect-Mitochondrial Diseases', 'MIEF2-protect-Mitochondrial Diseases', 'CDKN2A-increased-CCND1', 'TP53-include-Urinary Bladder Neoplasms', 'KDM6A-include-Urinary Bladder Neoplasms', 'RB1-include-Urinary Bladder Neoplasms', 'CD79A-correlate-Infections', 'CD79A-correlate-Inflammation', 'HP-correlate-Infections', 'HP-correlate-Inflammation', 'FGF21-be lower in-Alzheimer Disease', 'Angioedemas, Hereditary-associated-PLG', 'PLG-associated-Angioedemas, Hereditary', 'IRX2-identify-SPP1', 'CCL7-involved-Prostatic Neoplasms', 'IRX2-identify-Neoplasms', 'CYP2C9-be with-VKORC1', 'CYP2C9-be with-rs9934438', 'VKORC1-be in-Thromboembolism', 'rs9934438-be in-Thromboembolism', 'WRN-involved-Werner Syndrome', 'Metabolic Syndrome-include-Chronic Disease', 'Heart Diseases-release-MALAT1', 'Metabolic Syndrome-include-Peripheral Arterial Disease', 'Metabolic Syndrome-include-SHBG', 'WNT4-involved-Diverticulum', 'RHOU-involved-Diverticulum', 'FOXC1-promote cell proliferation by-AKT1', 'FOXC1-promote-Inflammation', 'PLAG1-display-Prostatic Neoplasms', 'Acute Kidney Injury-Loss of be-Neoplasms', 'CDKN2A-Loss of be-Neoplasms', 'FOXC1-regulate synoviocytes proliferation by-AKT1', 'FOXC1-provide-Arthritis, Rheumatoid', 'CDKN2B-Loss of be-Neoplasms', 'Alzheimer Disease-require-NGF', 'CHAT-co-localize-NTRK1', 'NTRK1-suggest-BDNF', 'NTRK1-suggest-Alzheimer Disease', 'IGF1R-overexpressed-MET', 'IGF1R-show-TERT', 'MET-show-TERT', 'Inflammation-show-IGF1R', 'Inflammation-overexpressed-MET', 'Inflammation-show-TERT', 'FGF21-proposed-INS', 'MSTN-proposed-INS', 'FGF21-proposed-Metabolic Diseases', 'MSTN-proposed-Metabolic Diseases', 'Diabetes Mellitus, Type 2-include-INS', 'RCAN1-facilitate-MAPT', 'RCAN1-facilitate-Nerve Degeneration', 'RCAN1-lead-Nerve Degeneration', 'Dermatitis, Atopic-increase-Hyperplasia', 'Dermatitis, Atopic-increase-S100A8', 'IL20-related-CXCL9', 'PNPLA3-drove-Fibrosis', 'HP-drove-Fibrosis', 'rs738409-drove-Fibrosis', 'IL5-decrease-Dermatitis, Atopic', 'IL13-decrease-Dermatitis, Atopic', 'Neoplasms-be with-AREG', 'Neoplasms-discern-AREG', 'Breast Neoplasms-be with-AREG', 'Breast Neoplasms-discern-AREG', 'AREG-express-ESR1', 'Neoplasms-discern-ESR1', 'Breast Neoplasms-discern-ESR1', 'APOC1-associated-Alzheimer Disease', 'Alzheimer Disease-associated-APOC1', 'GGH-suggest-GHRH', 'LEP-modulate-GGH', 'LEP-regulate-GGH', 'LEP-modulate-Hypothalamic Neoplasms', 'GGH-modulate-Hypothalamic Neoplasms', 'GHRH-be in-Obesity', 'GGH-be in-Obesity', 'GGH-suggest-Obesity', 'Fatty Acids, Essential-suppress-Fatty Acids', 'Fatty Acids, Essential-suppress-INS', 'Fatty Acids, Essential-suppress-Obesity', 'Fatty Acids, Essential-suppress-Diabetes Mellitus, Type 2', 'TRH-suggested-Neurologic Manifestations', 'Neurologic Manifestations-suggested-PRL', 'Capsaicin-restore-PRKAA1', 'Capsaicin-restore-TRPV1', 'TRPV1-suppress-SIRT1', 'TRPV1-abolish-Capsaicin', 'SIRT1-abolish-Capsaicin', 'TRPV1-evaluate-Capsaicin', 'PRKAA1-be in-Capsaicin', 'PRKAA1-evaluate-Capsaicin', 'SIRT1-be in-Capsaicin', 'SIRT1-evaluate-Capsaicin', 'CRP-include-Inflammation', 'HTRA1-associated-Glycogen Storage Disease Type II', 'Glycogen Storage Disease Type II-associated-HTRA1', 'CFH-exert-Glycogen Storage Disease Type II', 'HTRA1-exert-Glycogen Storage Disease Type II', 'Ischemia-mediate-CDK5', 'Idiopathic Pulmonary Fibrosis-be with-Lung Neoplasms', 'Coronary Artery Disease-regulate-CDK5', 'IL1B-decrease-Hyaluronic Acid', 'TTR-increase-Hyaluronic Acid', 'MATN3-increase-Hyaluronic Acid', 'HSF1-induce-FOXO3', 'rs2802292-create-HSF1', 'rs2802292-induce-FOXO3', 'HSF1-mediate-FOXO3', 'HSF1-mediate-rs2802292', 'FOXO3-involve-rs2802292', 'AKT1-indicate-MAPK8', 'Heart Arrest-indicate-AKT1', 'Heart Arrest-indicate-MAPK8', 'NEFL-differentiate-PSEN1', 'NEFL-begin-PSEN1', 'NEFL-differentiate-rs63750231', 'NEFL-begin-rs63750231', 'Hyperinsulinism-promote-SLC2A4', 'Hyperinsulinism-promote-LNPEP', 'NEFL-begin-Alzheimer Disease', 'BCL2-colocalized-Alzheimer Disease', 'BCL2-colocalized-Infarction', 'Sleep Initiation and Maintenance Disorders-investigate-FGF21', 'Sleep Initiation and Maintenance Disorders-suffer-FGF21', 'Sleep Initiation and Maintenance Disorders-investigate-GDF15', 'Sleep Initiation and Maintenance Disorders-suffer-GDF15', 'GGH-exert-Stroke', 'Leukemia-associated-VIM', 'VIM-associated-Leukemia', 'BRCA2-show-Neoplasms', 'ERCC2-show-Neoplasms', 'EGFR-induce-Neoplasms', 'AKT2-induce-Neoplasms', 'AK1-induce-Neoplasms', 'KL-verify-SIRT1', 'AKT3-induce-Neoplasms', 'KL-mediate-Calcinosis', 'SIRT1-mediate-Calcinosis', 'Prostatic Neoplasms-associated-Carcinogenesis', 'Carcinogenesis-associated-Prostatic Neoplasms', 'Prostatic Neoplasms-associated-GJB1', 'GJB1-associated-Prostatic Neoplasms', 'Carcinogenesis-associated-GJB1', 'GJB1-associated-Carcinogenesis', 'Carcinogenesis-associated-GJA1', 'GJA1-associated-Carcinogenesis', 'KL-attenuate-Calcinosis', 'MSTN-associated-CST3', 'CST3-associated-MSTN', 'MSTN-associated-H19', 'H19-associated-MSTN', 'MSTN-associated-Ataxia', 'Ataxia-associated-MSTN', 'Inflammation-improve-Fibromyalgia', 'Muscular Atrophy-improve-Fibromyalgia', 'Wilms Tumor-shown-OGG1', 'Wilms Tumor-shown-FEN1', 'Wilms Tumor-shown-rs1052133', 'CRP-improve-Fibromyalgia', 'Wilms Tumor-shown-rs174538', 'Wilms Tumor-shown-rs4246215', 'FOXM1-exert-SHH', 'RBP4-decreased-Alzheimer Disease', 'HP-decreased-Alzheimer Disease', 'Carcinoma, Basal Cell-exert-SHH', 'SHH-lead to-Neoplasms', 'SHH-exert-Neoplasms', 'ELN-correlated-APOA1', 'KLF2-involved-Inflammation', 'PLPP3-involved-Inflammation', 'Inflammation-contain-CTHRC1', 'Inflammation-involved-SCG2', 'rs10490924-be in-ARMS2', 'rs10490924-be in-HTRA1', 'rs10490924-found-CFB', 'SFRP2-secrete-Melanoma', 'Melanoma-result-MITF', 'TNFRSF11B-correlated-ADIPOQ', 'TNFRSF11B-correlated-Glucose', 'TNFRSF11B-correlated-Triglycerides', 'Hematuria-used-BDNF', 'Arthritis, Infectious-predict-Infections', 'CRP-predict-Infections', 'Infections-present-CRP', 'HFE-exceed-TF', 'rs1800562-exceed-TF', 'rs1799945-exceed-TF', 'Hemochromatosis-exceed-TF', 'MGP-mediate-Osteoporosis', 'BGLAP-mediate-Osteoporosis', 'SPP1-mediate-Osteoporosis', 'SIRT1-be promising effective therapeutics for-Parkinson Disease', 'SIRT2-be promising effective therapeutics for-Parkinson Disease', 'LEP-be in-Diabetes Mellitus', 'Diabetes Mellitus, Type 2-linked-Obesity', 'ADIPOQ-seem-Obesity', 'ADIPOQ-linked-Obesity', 'VEGFA-be in-Stomach Neoplasms', 'TP53-be important factors in-Neoplasms', 'VEGFA-be important factors in-Neoplasms', 'EPHB2-be responsible for-Mitochondrial Diseases', 'PTH-explain-Hyperparathyroidism, Primary', 'PTH-up-regulate-Hypoparathyroidism', 'POMC-measured-Glucose', 'MALAT1-guarantee-SOD1', 'MALAT1-guarantee-SOD2', 'Fatty Acids, Nonesterified-measured-Glucose', 'Seizures-high expression of-SOD1', 'Seizures-guarantee-SOD1', 'Seizures-guarantee-SOD2', 'MALAT1-guarantee-Seizures', 'IGF2BP2-stimulate-IGF2', 'HMGA1-stimulate-IGF2', 'IGF2BP2-stimulate-Neoplasms', 'IGF2BP2-drive-Neoplasms', 'IGF2BP2-account-Neoplasms', 'HMGA1-drive-Neoplasms', 'HMGA1-account-Neoplasms', 'IGF2-drive-Neoplasms', 'IGF2-account-Neoplasms', 'NOS3-co-stimulate-KNG1', 'NOS3-occur-Inflammation', 'Inflammation-co-stimulate-KNG1', 'GAS6-be better than-CST3', 'SIRT1-study-Myalgia', 'SIRT1-study-Myositis', 'Fibrosis-used-ARMS2', 'Fibrosis-used-HTRA1', 'SPP1-compare-Hypertension', 'RB1-restore-GAS6', 'RB1-mechanisms of-Calcinosis', 'RB1-inhibit-Calcinosis', 'Calcinosis-restore-GAS6', 'BHLHE40-treated-Glucose', 'Glucose-decreased-BATF', 'AR-effects through-GAS6', 'AR-effects on-Calcinosis', 'ACSS2-interact-KAT8', 'ACSS2-required-Acetates', 'KAT8-required-Acetates', 'BHLHE40-alleviate-Calcinosis', 'BATF-alleviate-Calcinosis', 'CRP-adjusted-LEP', 'CRP-adjusted-Death', 'CRP-adjusted-Cardiovascular Diseases', 'Death-be with-LEP', 'MAPT-phosphorylated-Alzheimer Disease', 'IL6-find-Multiple Myeloma', 'MAP1LC3A-enhanced-BANF1', 'SIRT1-be in-Retinal Degeneration', 'PARP1-associated-TP53', 'TP53-associated-PARP1', 'Hyperoxia-activator of-PARP1', 'Hyperoxia-associated-TP53', 'TP53-associated-Hyperoxia', 'INS-underlie-ADIPOQ', 'Obesity-associated-Prostatic Neoplasms', 'Prostatic Neoplasms-associated-Obesity', 'INS-associated-Prostatic Neoplasms', 'Prostatic Neoplasms-associated-INS', 'Obesity-underlie-ADIPOQ', 'ADIPOQ-association between-Prostatic Neoplasms', 'ADIPOQ-underlie-Prostatic Neoplasms', 'TLR4-increase-GAP43', 'SIRT1-be in-Obesity', 'SIRT2-correlate with-SIRT1', 'SIRT2-correlate with-Cholesterol', 'INS-reduce-Cardiovascular Diseases', 'INS-reduce-Diabetes Mellitus', 'CACNA1S-associate-Infliximab', 'Infliximab-associate-CACNA1S', 'RYR2-associate-Infliximab', 'Infliximab-associate-RYR2', 'SNCA-implicated-Parkinson Disease', 'UCHL1-implicated-Parkinson Disease', 'PINK1-implicated-Parkinson Disease', 'LRRK2-implicated-Parkinson Disease', 'rs2274924-show-rs11558471', 'rs2274924-show-rs3740393', 'AKT1-linked-Neoplasms', 'rs2274924-be in-TRPM6', 'TRPM6-show-rs11558471', 'rs2274924-show-SLC30A8', 'rs11558471-be in-SLC30A8', 'rs2274924-show-Glucose', 'Glucose-show-rs11558471', 'Glucose-show-rs3740393', 'Double Outlet Right Ventricle-driven-DNMT3A', 'BUB1B-involved-Hearing Loss', 'PHC2-involved-Hearing Loss', 'rs138684936-be in-NEB', 'TOP2A-involved-Hearing Loss', 'DDR2-involved-Hearing Loss', 'KLF13-involved-Hearing Loss', 'RYR2-involved-Hearing Loss', 'SMAD7-be with-Hyperplasia', 'SMAD7-correlate-Hyperplasia', 'Glutathione-commit-MTR', 'Glutathione-inhibit-CBS', 'MT2A-associated-IL6', 'IL6-associated-MT2A', 'Dyslipidemias-provoke-INS', 'MT2A-associated-Inflammation', 'Inflammation-associated-MT2A', 'rs1610216-associated-Inflammation', 'Inflammation-associated-rs1610216', 'CXCL10-be in-Osteoarthritis', 'DKK3-decrease mild with-Arthritis', 'Lung Neoplasms-defined-EGFR', 'Lung Neoplasms-defined-ALK', 'OXTR-investigated-Prostatic Hyperplasia', 'AR-investigated-Prostatic Hyperplasia', 'Ascorbic Acid-decrease-FTH1', 'Ascorbic Acid-decrease-FTL', 'Ascorbic Acid-cause-FTH1', 'Ascorbic Acid-cause-FTL', 'CD2AP-involve-Alzheimer Disease', 'SPON1-involve-Alzheimer Disease', 'Fractures, Bone-increase-GPT', 'Fractures, Bone-increase-SLC17A5', 'HMOX1-code-rs1695', 'rs1695-be in-GSTP1', 'rs1695-code-GSTP1', 'CCAR2-form-SIRT1', 'Breast Neoplasms-deleted-SIRT1', 'Hyperhomocysteinemia-define-Alzheimer Disease', 'Hyperhomocysteinemia-define-Dementia, Vascular', 'Hyperhomocysteinemia-define-Dementia', 'PENK-affected-Parkinson Disease', 'PDYN-affected-Parkinson Disease', 'CRP-associated-Hyperhomocysteinemia', 'Hyperhomocysteinemia-associated-CRP', 'IL6-define-Hyperhomocysteinemia', 'IL6-associated-Hyperhomocysteinemia', 'Hyperhomocysteinemia-associated-IL6', 'IL6-modulate-Astrocytoma', 'CXCL8-modulate-Astrocytoma', 'Adenomatous Polyposis Coli-observed-SMAD4', 'FOS-implicated-Scleroderma, Systemic', 'JUNB-implicated-Scleroderma, Systemic', 'SIRT1-proposed-SIRT2', 'ESR2-associated-Colorectal Neoplasms', 'Colorectal Neoplasms-associated-ESR2', 'SIRT1-proposed-Neoplasms', 'SIRT1-proposed-Arbovirus Infections', 'SIRT1-proposed-Fragile X Syndrome', 'SIRT1-prevent-Parasitic Diseases', 'SIRT1-prevent-Neurodegenerative Diseases', 'Parasitic Diseases-proposed-SIRT2', 'SIRT2-prevent-Neurodegenerative Diseases', 'CD4-result-Prostaglandins', 'NEFL-correlate-ALB', 'CD8A-result-Prostaglandins', 'Lipid Peroxides-measured-CAT', 'Lipid Peroxides-measured-GSR', 'Lipid Peroxides-measured-Glutathione', 'Lipid Peroxides-measured-Breast Neoplasms', 'Glutathione-measured-Breast Neoplasms', 'Lung Neoplasms-associated-CD4', 'CD4-associated-Lung Neoplasms', 'Lung Neoplasms-associated-CD8A', 'CD8A-associated-Lung Neoplasms', 'CYP2C8-associated-Neurodegenerative Diseases', 'Neurodegenerative Diseases-associated-CYP2C8', 'EPHX2-associated-Neurodegenerative Diseases', 'Neurodegenerative Diseases-associated-EPHX2', 'CYP4A11-associated-Neurodegenerative Diseases', 'Neurodegenerative Diseases-associated-CYP4A11', 'Dactinomycin-decreased-RGN', 'rs17110453-associated-Neurodegenerative Diseases', 'Neurodegenerative Diseases-associated-rs17110453', 'rs751141-associated-Neurodegenerative Diseases', 'Neurodegenerative Diseases-associated-rs751141', 'rs9333025-associated-Neurodegenerative Diseases', 'Neurodegenerative Diseases-associated-rs9333025', 'NGFR-targets in-Brain Diseases', 'Carcinoma, Hepatocellular-promote-EGFR', 'SIRT1-deacetylate-XRCC6', 'SIRT1-sequester-BAX', 'XRCC6-sequester-BAX', 'SIRT1-inhibit-Death', 'CCND1-be in-Breast Neoplasms', 'XRCC6-inhibit-Death', 'BAX-inhibit-Death', 'DNMT3A-associated-Leukemia', 'Leukemia-associated-DNMT3A', 'TET2-associated-Leukemia', 'Leukemia-associated-TET2', 'ASXL1-associated-Leukemia', 'Leukemia-associated-ASXL1', 'VDR-affect-Hypertension', 'Neoplasms-carry-BRCA1', 'Neoplasms-carry-BRCA2', 'Neoplasms-promote-Pigmentation Disorders', 'TP53-promote-Pigmentation Disorders', 'Pigmentation Disorders-demonstrated-POMC', 'FASLG-expressed-BAG3', 'Dementia-examine-APOE', 'CTSW-expressed-BAG3', 'FASLG-associated-Inflammation', 'Inflammation-associated-FASLG', 'CTSW-associated-Inflammation', 'Inflammation-associated-CTSW', 'IL10-result-Inflammation', 'CTSE-associated-Inflammation', 'Inflammation-associated-CTSE', 'VCAM1-associated-Inflammation', 'Inflammation-associated-VCAM1', 'BAG3-associated-Inflammation', 'Inflammation-associated-BAG3', 'Alzheimer Disease-have increase-VWF', 'Alzheimer Disease-increase-VWF', 'Alzheimer Disease-increase-THBD', 'HLA-DRB1-compare-Tuberculosis, Pulmonary', 'CD4-decline-Infections', 'CD8A-decline-Infections', 'NBEAL1-lead-rs2351524', 'WDR12-lead-rs2351524', 'SIRT1-of inhibition be-FOXO1', 'PARP1-lead-SIRT1', 'Cockayne Syndrome-result-PARP1', 'PARP1-lead-Mitochondrial Diseases', 'PARP1-activate-SIRT1', 'Neoplasms-altered-Leukemia, Myeloid, Acute', 'USP18-increased-INS', 'INS-worsen-USP18', 'Atazanavir Sulfate-worsen-INS', 'Hyperinsulinism-supply-Hypothalamic Neoplasms', 'Hypothalamic Neoplasms-supply-Hyperglycemia', 'Hypothalamic Neoplasms-prevent-Hyperglycemia', 'Diabetes Mellitus-supply-Hypothalamic Neoplasms', 'Obesity-supply-Hypothalamic Neoplasms', 'LEP-restrain-INS', 'Hyperglycemia-prevent-Diabetes Mellitus', 'Hyperglycemia-supply-Obesity', 'INS-supply-Hypothalamic Neoplasms', 'LEP-upregulate-Glucose', 'INS-prevent-Hyperglycemia', 'INS-upregulate-Glucose', 'LEP-be in-Hypothalamic Neoplasms', 'LEP-produced-Obesity', 'INS-initiate-Obesity', 'INS-restrain-Diabetes Mellitus', 'Hypothalamic Neoplasms-upregulate-Glucose', 'Glucose-upregulate-Obesity', 'Glucose-restrain-Diabetes Mellitus', 'TP53-progression with-SIRT1', 'TP53-increase-SIRT1', 'TP53-increase progression in-Osteoarthritis', 'Skin Neoplasms-prevent-Melanoma', 'Skin Neoplasms-reduce-MC1R', 'Skin Neoplasms-prevent-CDKN2A', 'SLC27A2-overcome resistance to-BRAF', 'SLC27A2-inhibit-BRAF', 'SLC27A2-inhibit-Neoplasms', 'Heart Arrest-induce-CDK2', 'Heart Arrest-induce-CCNB1', 'GIP-suppress-INS', 'Heart Arrest-induce-CDK1', 'GIP-suppress-GCG', 'INS-suppress-GIP', 'INS-suppress-GCG', 'INS-suppress-Glucose', 'PLA2G4A-contribute-Memory Disorders', 'PLA2G6-contribute-Alzheimer Disease', 'PLA2G6-contribute-Memory Disorders', 'APOE-protective against-Dementia', 'FOXO3-protective against-Dementia', 'SLPI-identified-Acanthosis Nigricans', 'SLPI-identified-Hyperkeratosis, Epidermolytic', 'SPRR2D-identified-Acanthosis Nigricans', 'SPRR2D-identified-Hyperkeratosis, Epidermolytic', 'ADIPOQ-affect-INS', 'ADIPOQ-associated-CRP', 'CRP-associated-ADIPOQ', 'ADIPOQ-associated-Cholesterol', 'Cholesterol-associated-ADIPOQ', 'CXCL8-discriminate-Cystitis', 'Colorectal Neoplasms-show-HMGB1', 'Colorectal Neoplasms-show-TRIM28', 'TCF3-show-Colorectal Neoplasms', 'Colorectal Neoplasms-show-TCF3', 'Calcitriol-repress-IL13', 'Colorectal Neoplasms-show-CERS5', 'ZNF346-show-Colorectal Neoplasms', 'Calcitriol-repress-Inflammation', 'Calcitriol-upregulate-SIRT1', 'Calcitriol-upregulate-VDR', 'Kidney Diseases-prevent-Multiple Chronic Conditions', 'Kidney Diseases-affect-MTOR', 'Kidney Diseases-affect-SIRT1', 'SIRT3-inhibited-SOD2', 'SIRT3-inhibited-Glucose', 'SIRT3-inhibited-Glycogen', 'SIRT3-reprogram-Stomach Neoplasms', 'SOD2-reprogram-Stomach Neoplasms', 'Glucose-reprogram-Stomach Neoplasms', 'Glutathione-induce-CFTR', 'Glycogen-reprogram-Stomach Neoplasms', 'Glutathione-induce-ABCC1', 'CCL20-associated-Asthma', 'Asthma-associated-CCL20', 'rs76349024-abilities of-GDF9', 'rs76349024-reduce-GDF9', 'Cardiovascular Diseases-be with-EPO', 'LEP-associated-Fractures, Bone', 'Fractures, Bone-associated-LEP', 'ADIPOQ-associated-Fractures, Bone', 'Fractures, Bone-associated-ADIPOQ', 'AQP1-affected-MAPT', 'AQP1-observed-Alzheimer Disease', 'AQP1-affected-Alzheimer Disease', 'TMEM37-overexpressed-Neoplasms', 'BCL2-overexpressed-Neoplasms', 'CTSD-overexpressed-Neoplasms', 'TNFRSF11B-be higher in-Diabetes Mellitus, Type 2', 'CCL5-be higher in-Diabetes Mellitus, Type 2', 'Obesity-be with-Diabetes Mellitus, Type 2', 'Obesity-reduce-TNFRSF11B', 'TRG-assessed-CD8A', 'TRB-assessed-CD8A', 'TRG-assessed-Rheumatic Diseases', 'TRG-assessed-Lymphocytosis', 'TRB-assessed-Rheumatic Diseases', 'TRB-assessed-Lymphocytosis', 'GADD45A-associated-Heart Arrest', 'Heart Arrest-associated-GADD45A', 'PMP22-associated-Heart Arrest', 'Heart Arrest-associated-PMP22', 'BEX2-associated-Heart Arrest', 'Heart Arrest-associated-BEX2', 'CGREF1-associated-Heart Arrest', 'Heart Arrest-associated-CGREF1', 'CCN1-associated-Heart Arrest', 'Heart Arrest-associated-CCN1', 'CD8A-be in-Atherosclerosis', 'CD8A-operate-CX3CL1', 'CD8A-drive-TNF', 'CD8A-demonstrate-Atherosclerosis', 'CX3CL1-drive-TNF', 'GSTM1-observed-Parkinson Disease', 'GSTP1-observed-Parkinson Disease', 'Atherosclerosis-operate-CX3CL1', 'Atherosclerosis-drive-TNF', 'TNFRSF12A-play-Muscular Atrophy', 'TNFRSF12A-play-Fibrosis', 'IL6-associated-MT1A', 'MT1A-associated-IL6', 'BAX-include-Death', 'BCL2-include-Death', 'TP53-include-Death', 'ESR1-decreased-MAPT', 'ESR1-decreased-Alzheimer Disease', 'Alzheimer Disease-be with-MAPT', 'APOE-modulate-MAPT', 'POSTN-involved-IL4', 'POSTN-involved-IL13', 'POSTN-play role in-Fibrosis', 'Fibrosis-involved-IL4', 'Fibrosis-involved-IL13', 'ADIPOQ-correlate with-INS', 'ADIPOQ-correlate-Triglycerides', 'FGF21-base-VWF', 'FGF21-increased-Hypertension', 'TNF-correlate-ADIPOQ', 'CRP-prevent-Metabolic Diseases', 'MAPT-generate-Neurotoxicity Syndromes', 'TNF-prevent-Metabolic Diseases', 'ADIPOQ-prevent-Metabolic Diseases', 'Obesity-be with-Polycystic Ovary Syndrome', 'INS-contribute-Polycystic Ovary Syndrome', 'AMH-contribute in-Obesity', 'AMH-contribute in-Polycystic Ovary Syndrome', 'Glucose-reduce-FOXO1', 'Glucose-reduce-CAT', 'M6PR-of allele be-GPX6', 'M6PR-of allele be-TXN2', 'rs1805754-of allele be-rs406113', 'rs1805754-of allele be-rs2281082', 'Thrombocythemia, Essential-mediated-JAK2', 'Primary Myelofibrosis-mediated-JAK2', 'Thrombocythemia, Essential-mediated-MPL', 'Primary Myelofibrosis-mediated-MPL', 'EGF-associated-SIRT1', 'SIRT1-associated-EGF', 'M6PR-of allele be-rs406113', 'EGF-associated-Heart Arrest', 'Heart Arrest-associated-EGF', 'M6PR-of allele be-rs2281082', 'rs1805754-of allele be-GPX6', 'SIRT3-antagonize senescence via-FOXO1', 'SIRT3-antagonize-Glucose', 'rs1805754-of allele be-TXN2', 'M6PR-variant allele of be-Fractures, Bone', 'SIRT1-prevent-NOS3', 'rs1805754-variant allele of be-Fractures, Bone', 'KL-associate-IL10', 'IL10-associate-KL', 'KL-constitute-IL10', 'KL-associate-CRP', 'CRP-associate-KL', 'KL-show-CRP', 'Cardiovascular Diseases-constitute-IL10', 'Cardiovascular Diseases-show-CRP', 'Glucose-fast-INS', 'Cholesterol-confirm-Glucose', 'CAT-chaperone for-SOD1', 'PLA2G4A-linked-PLA2G6', 'Arachidonic Acid-released-Phospholipids', 'Arachidonic Acid-linked-Docosahexaenoic Acids', 'Docosahexaenoic Acids-linked-Phospholipids', 'Arachidonic Acid-released-PLA2G4A', 'Phospholipids-released-PLA2G4A', 'PLA2G4A-linked-Docosahexaenoic Acids', 'Arachidonic Acid-linked-PLA2G6', 'Phospholipids-linked-PLA2G6', 'Docosahexaenoic Acids-linked-PLA2G6', 'NPPA-associated-PDE10A', 'PDE10A-associated-NPPA', 'HIF1A-associated-AP2B1', 'AP2B1-associated-HIF1A', 'NPPA-associated-Dementia', 'Dementia-associated-NPPA', 'HIF1A-associated-PTK2', 'PTK2-associated-HIF1A', 'NPPA-associated-Alzheimer Disease', 'Alzheimer Disease-associated-NPPA', 'HIF1A-associated-CNTFR', 'CNTFR-associated-HIF1A', 'NPPA-associated-Huntington Disease', 'Huntington Disease-associated-NPPA', 'HIF1A-associated-ACVR1B', 'ACVR1B-associated-HIF1A', 'NPPA-associated-Parkinson Disease', 'Parkinson Disease-associated-NPPA', 'EPO-noted-Neoplasms', 'EPOR-noted-Neoplasms', 'HIF1A-associated-CNTF', 'CNTF-associated-HIF1A', 'HIF1A-associated-TRHR', 'TRHR-associated-HIF1A', 'HIF1A-associated-MSTN', 'MSTN-associated-HIF1A', 'HIF1A-associated-COL1A1', 'COL1A1-associated-HIF1A', 'PDE10A-be in-Huntington Disease', 'HIF1A-associated-FTO', 'FTO-associated-HIF1A', 'EPO-examined-Carcinoma, Merkel Cell', 'EPOR-examined-Carcinoma, Merkel Cell', 'VEGFA-examined-Carcinoma, Merkel Cell', 'KDR-examined-Carcinoma, Merkel Cell', 'rs11549465-associated-rs4341', 'rs4341-associated-rs11549465', 'rs11549465-associated-rs7460', 'rs7460-associated-rs11549465', 'rs11549465-associated-rs2070802', 'rs2070802-associated-rs11549465', 'DYNLRB2-identified-Kartagener Syndrome', 'DYNLRB2-identified-Alzheimer Disease', 'ZMYND10-identified-Kartagener Syndrome', 'ZMYND10-identified-Alzheimer Disease', 'rs11549465-associated-rs17421511', 'rs17421511-associated-rs11549465', 'DNAH5-identified-Kartagener Syndrome', 'DNAH5-identified-Alzheimer Disease', 'CFAP52-identified-Kartagener Syndrome', 'CFAP52-identified-Alzheimer Disease', 'ODAD2-identified-Kartagener Syndrome', 'ODAD2-identified-Alzheimer Disease', 'rs11549465-associated-rs10783485', 'rs10783485-associated-rs11549465', 'rs11549465-associated-rs1800169', 'rs1800169-associated-rs11549465', 'rs11549465-associated-rs1801131', 'rs1801131-associated-rs11549465', 'rs11549465-associated-rs1537516', 'rs1537516-associated-rs11549465', 'rs11549465-associated-rs7832552', 'rs7832552-associated-rs11549465', 'rs11549465-associated-rs1805086', 'rs1805086-associated-rs11549465', 'rs11549465-associated-rs1800012', 'rs1800012-associated-rs11549465', 'rs11549465-associated-rs9939609', 'rs9939609-associated-rs11549465', 'RBP4-contribute-INS', 'RBP4-contribute-Diabetes Mellitus', 'INS-contribute-Diabetes Mellitus', 'RBP4-identify-INS', 'RBP4-identify-Glucose', 'RBP4-increase-Glucose', 'GDF15-maintain-INS', 'Inflammation-maintain-Glucose Metabolism Disorders', 'RBP4-correlate-INS', 'RBP4-correlate-Glucose', 'GDF15-be indispensable for-Inflammation', 'GDF15-attenuate-Inflammation', 'GDF15-maintain-Glucose Metabolism Disorders', 'Inflammation-maintain-INS', 'TP53-lead-Neoplasms', 'ATM-lead-Neoplasms', 'TERF2-lead-Neoplasms', 'IL6-associated-TNF', 'TNF-associated-IL6', 'IL6-associated-Lung Diseases, Obstructive', 'Lung Diseases, Obstructive-associated-IL6', 'TNF-associated-Lung Diseases, Obstructive', 'Lung Diseases, Obstructive-associated-TNF', 'HIF1A-associated-rs4341', 'rs4341-associated-HIF1A', 'HIF1A-associated-rs7460', 'rs7460-associated-HIF1A', 'HIF1A-associated-rs2070802', 'rs2070802-associated-HIF1A', 'HIF1A-associated-rs17421511', 'rs17421511-associated-HIF1A', 'HIF1A-associated-rs10783485', 'rs10783485-associated-HIF1A', 'HIF1A-associated-rs1800169', 'rs1800169-associated-HIF1A', 'HIF1A-associated-rs1801131', 'rs1801131-associated-HIF1A', 'HIF1A-associated-rs1537516', 'rs1537516-associated-HIF1A', 'HIF1A-associated-rs7832552', 'rs7832552-associated-HIF1A', 'HIF1A-associated-rs1805086', 'rs1805086-associated-HIF1A', 'HIF1A-associated-rs1800012', 'rs1800012-associated-HIF1A', 'HIF1A-associated-rs9939609', 'rs9939609-associated-HIF1A', 'rs11549465-associated-AP2B1', 'AP2B1-associated-rs11549465', 'rs11549465-associated-PTK2', 'PTK2-associated-rs11549465', 'rs11549465-associated-CNTFR', 'CNTFR-associated-rs11549465', 'rs11549465-associated-ACVR1B', 'ACVR1B-associated-rs11549465', 'rs11549465-associated-CNTF', 'CNTF-associated-rs11549465', 'rs11549465-associated-TRHR', 'TRHR-associated-rs11549465', 'rs11549465-associated-MSTN', 'MSTN-associated-rs11549465', 'INS-include-SHBG', 'Triglycerides-include-SHBG', 'rs11549465-associated-COL1A1', 'COL1A1-associated-rs11549465', 'rs11549465-associated-FTO', 'FTO-associated-rs11549465', 'WWC1-involved-Alzheimer Disease', 'APOE-involved-Alzheimer Disease', 'Metabolic Syndrome-demonstrate-TF', 'ITPR1-use-MAPK1', 'ITPR1-suggest-Sarcopenia', 'Sarcopenia-use-MAPK1', 'Inflammation-regulate-Atherosclerosis', 'LEP-regulate-Inflammation', 'ADIPOQ-involved-Inflammation', 'ADIPOQ-regulate-Inflammation', 'LEP-associated-Inflammation', 'Inflammation-associated-LEP', 'ADIPOQ-associated-Inflammation', 'Inflammation-associated-ADIPOQ', 'LEP-report-ADIPOQ', 'Eicosapentaenoic Acid-measure-LEP', 'Docosahexaenoic Acids-measure-LEP', 'Eicosapentaenoic Acid-measure-ADIPOQ', 'Docosahexaenoic Acids-measure-ADIPOQ', 'Eicosapentaenoic Acid-assess-Docosahexaenoic Acids', 'LEP-assess-Eicosapentaenoic Acid', 'LEP-assess-Docosahexaenoic Acids', 'ADIPOQ-assess-Eicosapentaenoic Acid', 'ADIPOQ-assess-Docosahexaenoic Acids', 'IL15-include-Pulmonary Disease, Chronic Obstructive', 'TNF-include-Pulmonary Disease, Chronic Obstructive', 'JUP-include-Pulmonary Disease, Chronic Obstructive', 'CD4-indicate-Dendritic Cell Sarcoma, Follicular', 'IL3RA-indicate-Dendritic Cell Sarcoma, Follicular', 'CLTC-associated-Neoplasms', 'Neoplasms-associated-CLTC', 'ALK-associated-Neoplasms', 'Neoplasms-associated-ALK', 'ERCC2-implicated-GTF2H5', 'ERCC2-implicated-Trichothiodystrophy Syndromes', 'Trichothiodystrophy Syndromes-implicated-GTF2H5', 'INS-result-BSCL2', 'INS-result-AGPAT2', 'INS-result-Triglycerides', 'HMGCR-increase-Cholesterol', 'Lipodystrophy, Congenital Generalized-characterized-INS', 'UBIAD1-increase-Cholesterol', 'UBIAD1-prevent-HMGCR', 'Genetic Diseases, Inborn-characterized-INS', 'Lipodystrophy, Congenital Generalized-result-BSCL2', 'Lipodystrophy, Congenital Generalized-characterized-Triglycerides', 'Lipodystrophy, Congenital Generalized-result-Triglycerides', 'Genetic Diseases, Inborn-characterized-Triglycerides', 'RYR1-depleted-FKBP1A', 'Heart Failure-depleted-FKBP1A', 'Glutathione-include-CAT', 'Glutathione-include-GSR', 'Pneumonia-depend-RORA', 'Osteoarthritis-induced-Obesity', 'CD8A-compare-CD40', 'CD4-compare-CD40', 'Bleomycin-reversed-AKT2', 'CD8A-compare-CD4', 'Bleomycin-reversed-AKT1', 'CD40-reduce-Breast Neoplasms', 'CCND1-reduce-Breast Neoplasms', 'Neoplasms-function-CDC42', 'ARHGEF2-function In-Neoplasms', 'Hip Fractures-be with-Delirium', 'Obesity-lead-Myotonic Dystrophy', 'Neoplasms-identified-Fanconi Anemia', 'Neoplasms-designated-Fanconi Anemia', 'SLTM-associated-COG2', 'COG2-associated-SLTM', 'Neoplasms-identified-WRN', 'Neoplasms-inhibit-WRN', 'SLTM-associated-Cholesterol', 'Cholesterol-associated-SLTM', 'Neoplasms-identified-RECQL', 'Neoplasms-designated-RECQL', 'MEF2C-include-Gout', 'NFATC2-include-Gout', 'MAPK14-over-express-BAX', 'Glutathione-over-express-BAX', 'APOE-use-Porencephaly', 'BIN1-use-Porencephaly', 'MS4A6A-use-Porencephaly', 'CD2AP-use-Porencephaly', 'PICALM-use-Porencephaly', 'CLU-use-Porencephaly', 'EPHA1-use-Porencephaly', 'LEP-increase-ADIPOQ', 'CRP-increase-ADIPOQ', 'Inflammation-decreased-LEP', 'Inflammation-decreased-CRP', 'Inflammation-increase-ADIPOQ', 'Weight Loss-lead-ADIPOQ', 'Weight Loss-lead-LEP', 'BDNF-interact-SORL1', 'Heart Arrest-lead-CCND1', 'TLR2-implicated-Synucleinopathies', 'TLR2-be elevated in-Parkinson Disease', 'Pneumonia-collected-IL6', 'Pneumonia-collected-CXCL10', 'Pneumonia-collected-CD163', 'HOXB5-associated-Obesity', 'Obesity-associated-HOXB5', 'OLFM4-associated-Obesity', 'Obesity-associated-OLFM4', 'MC4R-associated-Obesity', 'Obesity-associated-MC4R', 'GJA5-associated-Atrial Fibrillation', 'Atrial Fibrillation-associated-GJA5', 'TFAP2B-associated-Obesity', 'Obesity-associated-TFAP2B', 'KCNJ2-associated-Atrial Fibrillation', 'Atrial Fibrillation-associated-KCNJ2', 'rs12970134-associated-Obesity', 'Obesity-associated-rs12970134', 'rs35594137-associated-Atrial Fibrillation', 'Atrial Fibrillation-associated-rs35594137', 'rs987237-associated-Obesity', 'Obesity-associated-rs987237', 'rs8079702-associated-Atrial Fibrillation', 'Atrial Fibrillation-associated-rs8079702', 'CNP-evaluate-Alzheimer Disease', 'DPYSL2-evaluate-Alzheimer Disease', 'HIV Infections-marked-IL2', 'SIRT3-lie-HRAS', 'SIRT3-test-rs11555236', 'WWOX-contain-Alzheimer Disease', 'WWOX-implicated-Alzheimer Disease', 'MAF-contain-Alzheimer Disease', 'MAF-implicated-Alzheimer Disease', 'Retinal Diseases-cells including-Retinal Degeneration', 'Blood Coagulation Disorders-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-Blood Coagulation Disorders', 'Blood Coagulation Disorders-associated-Opportunistic Infections', 'Opportunistic Infections-associated-Blood Coagulation Disorders', 'Atherosclerosis-observed-VEGFA', 'BRCA1-be modifiers of-Breast Neoplasms', 'BRCA2-be modifiers of-Breast Neoplasms', 'IL6-associated-Opportunistic Infections', 'Opportunistic Infections-associated-IL6', 'PTEN-activate-AKT1', 'Death-show-CRP', 'PTEN-inhibit-Neurotoxicity Syndromes', 'AKT1-inhibit-Neurotoxicity Syndromes', 'Anemia-show-CRP', 'AKT1-upregulate-NFE2L2', 'AKT1-upregulate-NANOG', 'APLP2-found-Fractures, Bone', 'BACE1-found-Fractures, Bone', 'NFE2L2-activate-INS', 'NANOG-activate-INS', 'Drug-Related Side Effects and Adverse Reactions-activate-Alzheimer Disease', 'Drug-Related Side Effects and Adverse Reactions-activate-AKT1', 'Drug-Related Side Effects and Adverse Reactions-upregulate-NFE2L2', 'NFE2L2-activate-Alzheimer Disease', 'Drug-Related Side Effects and Adverse Reactions-upregulate-NANOG', 'NANOG-reduced-Alzheimer Disease', 'LARP7-reduced-Alzheimer Disease', 'NANOG-activate-Alzheimer Disease', 'Drug-Related Side Effects and Adverse Reactions-activate-INS', 'ACE2-evidenced-Peripheral Arterial Disease', 'Heart Arrest-studied-MMP3', 'Heart Arrest-studied-COL1A1', 'Heart Arrest-studied-TIMP3', 'Heart Arrest-studied-TERT', 'TP53-altered-Neoplasms', 'HSPD1-suppress-Drug-Related Side Effects and Adverse Reactions', 'DCTN6-altered-Neoplasms', 'CDKN2A-altered-Neoplasms', 'GDF15-determined-Lipopolysaccharides', 'Colorectal Neoplasms-be with-CLCA4', 'Colorectal Neoplasms-screened-CLCA4', 'Colorectal Neoplasms-screened-GUCA2A', 'Colorectal Neoplasms-screened-SST', 'Colorectal Neoplasms-screened-MS4A12', 'Colorectal Neoplasms-screened-PLP1', 'Colorectal Neoplasms-screened-PYY', 'Colorectal Neoplasms-screened-VIP', 'Colorectal Neoplasms-screened-GUCA2B', 'NXNL1-be important for-MSRA', 'NXNL1-be important for-Cataract', 'MEG8-interact with-CIRBP', 'MEG8-interact-HADHB', 'Acalculous Cholecystitis-be in-CD4', 'Acalculous Cholecystitis-be in-CD8A', 'CST3-show-Death', 'CRP-show-Death', 'Death-follow-CST3', 'TGFA-involved-ZEB2', 'ZEB2-repress-CDH1', 'IL1A-involved-ZEB2', 'ZEB2-repress-CLDN4', 'AKT1-involved-ZEB2', 'ZEB2-repress-CCND1', 'ZEB2-repress-TERT', 'ZEB2-repress-SFRP1', 'Hypoxia-involved-ZEB2', 'ZEB2-repress-ALPL', 'TGFA-upregulate-ZEB2', 'IL1A-upregulate-ZEB2', 'Hypoxia-upregulate-ZEB2', 'ZEB2-induce-Heart Arrest', 'Death-be in-Heredodegenerative Disorders, Nervous System', 'NEFL-serve-Death', 'NEFL-associated-Heredodegenerative Disorders, Nervous System', 'Heredodegenerative Disorders, Nervous System-associated-NEFL', 'MAPT-serve-Death', 'MAPT-associated-Heredodegenerative Disorders, Nervous System', 'Heredodegenerative Disorders, Nervous System-associated-MAPT', 'ACE-differ-KNG1', 'ACE-differ-Cough', 'Cough-related-KNG1', 'CD4-correlate-Acquired Immunodeficiency Syndrome', 'CD8A-correlate-Acquired Immunodeficiency Syndrome', 'Atherosclerosis-regulate-Calcinosis', 'Atherosclerosis-regulate-Vascular Calcification', 'SPP1-expressed-Atherosclerosis', 'SPP1-regulate-Calcinosis', 'SPP1-regulate-Vascular Calcification', 'MGP-expressed-Atherosclerosis', 'MGP-regulate-Calcinosis', 'MGP-regulate-Vascular Calcification', 'BGLAP-expressed-Atherosclerosis', 'BGLAP-regulate-Calcinosis', 'BGLAP-regulate-Vascular Calcification', 'Atherosclerosis-regulate-Cholecalciferol', 'Cholecalciferol-regulate-Calcinosis', 'Cholecalciferol-regulate-Vascular Calcification', 'RARRES2-be in-Carcinoma, Squamous Cell', 'RARRES2-Silencing-Carcinoma, Squamous Cell', 'CMKLR1-upregulated-Carcinoma, Squamous Cell', 'RARRES2-trigger MAPK cascade via-MAPK8', 'CCRL2-upregulated-Carcinoma, Squamous Cell', 'RARRES2-impair-CMKLR2', 'MAPK8-trigger-CCRL2', 'MAPK8-impair-CMKLR2', 'TET2-impair-Inflammation', 'MAPK3-impair-CMKLR2', 'DNMT3A-impair-Inflammation', 'CCRL2-impair-CMKLR2', 'RARRES2-trigger-Carcinoma, Squamous Cell', 'MAPK8-trigger-Carcinoma, Squamous Cell', 'Carcinoma, Squamous Cell-trigger-CCRL2', 'Carcinoma, Squamous Cell-impair-CMKLR2', 'CX3CL1-represent-INS', 'CX3CL1-regulatory mechanism for-Pancreatitis', 'CX3CL1-represent-Pancreatitis', 'Dementia-characterized-MAPT', 'Dementia-characterized-MAP2', 'ITGAE-correlate-Neoplasms', 'CD8A-correlate-Neoplasms', 'SENP2-act-Neoplasms', 'CRP-measured-CYP11B2', 'CRP-measured-rs1799998', 'EIF2AK3-associated-Heart Arrest', 'Heart Arrest-associated-EIF2AK3', 'ERN1-associated-Heart Arrest', 'Heart Arrest-associated-ERN1', 'Rhabdoid Tumor-be positive for-SLC4A1', 'Rhabdoid Tumor-be positive for-SLC4A3', 'Death-mediated-PTK2B', 'Death-mediated-FOXO3', 'GPER1-prevent fibrosis through-NOX1', 'GPER1-associated-NOX1', 'NOX1-associated-GPER1', 'GPER1-reduce-Hypertension', 'GPER1-associated-Hypertension', 'Hypertension-associated-GPER1', 'GPER1-prevent-Fibrosis', 'GPER1-associated-Fibrosis', 'Fibrosis-associated-GPER1', 'GPER1-associated-Cerebrovascular Disorders', 'Cerebrovascular Disorders-associated-GPER1', 'Hypertension-reduce-NOX1', 'Fibrosis-prevent-NOX1', 'Cerebrovascular Disorders-prevent-NOX1', 'Parkinson Disease-characterised-VAMP2', 'Parkinson Disease-characterised-STX1A', 'Parkinson Disease-characterised-PAK1', 'OGG1-bind-PARP1', 'OGG1-bind-Nervous System Diseases', 'Delirium-rise-MAPT', 'Dementia-rise-MAPT', 'Delirium-rise-NEFL', 'BNIP3-implicated-Heart Diseases', 'BNIP3-implicated-Coronary Artery Disease', 'BNIP3L-implicated-Heart Diseases', 'BNIP3L-implicated-Coronary Artery Disease', 'BNIP3-implicated-Neurodegenerative Diseases', 'BNIP3L-implicated-Neurodegenerative Diseases', 'Alzheimer Disease-diminish-IDE', 'Alzheimer Disease-diminish-MME', 'Calcitriol-increase-ALPP', 'Calcitriol-increase-BGLAP', 'Adrenal Gland Neoplasms-increase-GGH', 'NEFL-assessed-Alzheimer Disease', 'NEFL-show-MAPT', 'NEFL-affected-Alzheimer Disease', 'Alzheimer Disease-affected-MAPT', 'GCLC-involved-Glutathione', 'GCLM-involved-Glutathione', 'BDNF-include-Parkinson Disease', 'Parkinson Disease-include-NTRK2', 'NTRK2-include-Parkinson Disease', 'Hypoxia-decrease-PTK2B', 'Hypoxia-decrease-AKT1', 'Hypoxia-decrease-MTOR', 'Inflammation-promote-Atherosclerosis', 'RAB7B-compare-RAB5A', 'ABCA1-treated-VEGFA', 'CYP4F2-treated-VEGFA', 'rs1883025-treated-VEGFA', 'rs9257445-associated-rs6060627', 'rs6060627-associated-rs9257445', 'rs9257445-associated-BCL2L1', 'BCL2L1-associated-rs9257445', 'rs2108622-treated-VEGFA', 'rs9257445-associated-Neoplasms', 'Neoplasms-associated-rs9257445', 'ALPP-be with-Death', 'ALPP-be with-Neoplasms', 'ANGPTL2-correlated-Coronary Artery Disease', 'IL18-express-IL17A', 'Ionomycin-express-IL17A', 'MME-remain-IDE', 'MME-remain-ECE1', 'MME-down-regulated-Alzheimer Disease', 'Heart Arrest-mediated-TP53', 'MME-down-regulated-Dementia', 'ELK1-mediate-TGFA', 'Idiopathic Pulmonary Fibrosis-develop-Fibrosis', 'Idiopathic Pulmonary Fibrosis-lack-ELK1', 'ELK1-develop-Fibrosis', 'Idiopathic Pulmonary Fibrosis-mediate-TGFA', 'Fibrosis-mediate-TGFA', 'SIRT1-activate-PRKAA1', 'NFE2L2-activate-PRKAA1', 'Neoplasms-related-SIRT1', 'Neoplasms-related-NFE2L2', 'Neoplasms-activate-PRKAA1', 'Neoplasms-include-Prostatic Neoplasms', 'IGF1R-associated-IGF1', 'IGF1-associated-IGF1R', 'Death-include-Prostatic Neoplasms', 'Prostatic Neoplasms-include-MAPK1', 'Prostatic Neoplasms-cause-MAPK1', 'Neoplasms-include-MAPK1', 'Neoplasms-cause-MAPK1', 'MAPK1-cause-Death', 'Prostatic Neoplasms-include-CCND1', 'Prostatic Neoplasms-cause-CCND1', 'Neoplasms-include-CCND1', 'Neoplasms-cause-CCND1', 'Death-cause-CCND1', 'IGF1R-cause delay after-IGF1', 'IGF1R-indicate-Neurologic Manifestations', 'IGF1-indicate-Neurologic Manifestations', 'Adenocarcinoma of Lung-associated-Parkinson Disease', 'Parkinson Disease-associated-Adenocarcinoma of Lung', 'EEF1A1-associated-Parkinson Disease', 'Parkinson Disease-associated-EEF1A1', 'CTSS-associated-Parkinson Disease', 'Parkinson Disease-associated-CTSS', 'MALAT1-associated-Parkinson Disease', 'Parkinson Disease-associated-MALAT1', 'EGFR-be with-ALB', 'FOXE1-associated-Thyroid Neoplasms', 'Thyroid Neoplasms-associated-FOXE1', 'TTF2-associated-Thyroid Neoplasms', 'Thyroid Neoplasms-associated-TTF2', 'FOXM1-lead by-CCNB1', 'FOXM1-upregulate-CCNB1', 'FOXM1-upregulate-AURKB', 'Glucose-be with-ALB', 'FOXM1-upregulate-MYC', 'FOXM1-upregulate-SKP2', 'FOXM1-upregulate-ZEB1', 'Hypertension-associate-EGFR', 'EGFR-associate-Hypertension', 'FOXM1-upregulate-ZEB2', 'CCNB1-upregulate-ZEB1', 'AURKB-upregulate-ZEB1', 'MYC-upregulate-ZEB1', 'INS-include-Cardiovascular Diseases', 'SKP2-upregulate-ZEB1', 'Cardiovascular Diseases-linked-Diabetes Mellitus, Type 2', 'Cardiovascular Diseases-reflect-ADIPOQ', 'Diabetes Mellitus, Type 2-reflect-ADIPOQ', 'FNDC5-reflect-INS', 'Diabetes Mellitus-be with-Obesity', 'FNDC5-reflect-Diabetes Mellitus', 'FNDC5-reflect-Obesity', 'PLIN1-analyzed-Triglycerides', 'SNAP23-analyzed-Triglycerides', 'Triglycerides-analyzed-Glycogen', 'FOXO1-be important player in-INS', 'FOXO1-be important player due-Glucose', 'VWF-increase-Hemorrhage', 'F8-increase-Hemorrhage', 'ABCG1-prevent-Atherosclerosis', 'Cholesterol-prevent-Atherosclerosis', 'RPS6KB2-involved-MTOR', 'RPS6KB2-involved-Idiopathic Pulmonary Fibrosis', 'Neoplasms-known-DiGeorge Syndrome', 'SLC25A1-delete-Neoplasms', 'SLC25A1-known-DiGeorge Syndrome', 'CIC-delete-Neoplasms', 'CIC-known-DiGeorge Syndrome', 'FUS-associated-Neurodegenerative Diseases', 'Neurodegenerative Diseases-associated-FUS', 'INS-drive-MTOR', 'MTOR-drive-Diabetes Mellitus', 'ALB-compared-Hypocalcemia', 'CRP-compared-Hypocalcemia', 'SIRT1-of knockdown be-Neoplasms', 'SIRT1-induce-Neoplasms', 'SIRT2-induce-Neoplasms', 'Cardiovascular Diseases-exhibit-NOS3', 'Cardiovascular Diseases-exhibit-MT-CO2', 'Cardiovascular Diseases-exhibit-TERF1', 'BGLAP-associated-INS', 'INS-associated-BGLAP', 'YAP1-associated-PGR', 'PGR-associated-YAP1', 'YAP1-be localized within-Neoplasms', 'YAP1-be independent favorable predictors among-Breast Neoplasms', 'PGR-be independent favorable predictors among-Breast Neoplasms', 'ENPP2-associated-Inflammation', 'Inflammation-associated-ENPP2', 'ENPP2-associated-Fibrosis', 'Fibrosis-associated-ENPP2', 'LPAR1-associated-Inflammation', 'Inflammation-associated-LPAR1', 'LPAR1-associated-Fibrosis', 'Fibrosis-associated-LPAR1', 'LPAR1-reduce-Inflammation', 'Kidney Diseases-include-Genetic Diseases, Inborn', 'Peripheral Nervous System Diseases-include-Genetic Diseases, Inborn', 'Thrombocytopenia-include-Genetic Diseases, Inborn', 'Primary Ovarian Insufficiency-include-Genetic Diseases, Inborn', 'Hearing Loss-include-Genetic Diseases, Inborn', 'Cardiomyopathies-include-Genetic Diseases, Inborn', 'LEP-possess-APOE', 'LEP-exhibit-Alzheimer Disease', 'Alzheimer Disease-possess-APOE', 'PLIN2-associated-IL6', 'IL6-associated-PLIN2', 'PLIN2-be higher with-Tauopathies', 'INF2-identified-Genetic Diseases, Inborn', 'INF2-identified-Kidney Diseases', 'INF2-identified-Peripheral Nervous System Diseases', 'INF2-identified-Thrombocytopenia', 'INF2-identified-Primary Ovarian Insufficiency', 'FHOD3-identified-Genetic Diseases, Inborn', 'FHOD3-identified-Kidney Diseases', 'FHOD3-identified-Peripheral Nervous System Diseases', 'FHOD3-identified-Thrombocytopenia', 'FHOD3-identified-Primary Ovarian Insufficiency', 'ACE2-include-Cerebral Hemorrhage', 'IL2-associated-Delirium', 'Delirium-associated-IL2', 'ACE-include-Cerebral Hemorrhage', 'VDR-improve-BRCA1', 'VDR-improve-TP53BP1', 'Progeria-expression of-VDR', 'Progeria-reduce-VDR', 'VDR-improve-Progeria', 'VDR-reconstitute-Progeria', 'Progeria-improve-BRCA1', 'Progeria-improve-TP53BP1', 'Progeria-reduce-BRCA1', 'Progeria-stabilize-TP53BP1', 'Hypertension-be in-CALCA', 'Prostatic Hyperplasia-have elevated levels in-POMC', 'Fatty Acids, Essential-reverse-INS', 'MIF-be lower in-Osteoarthritis', 'Alzheimer Disease-found-F3', 'Alzheimer Disease-found-TFR2', 'MIF-associated-Osteoarthritis', 'Osteoarthritis-associated-MIF', 'Alzheimer Disease-found-ACO1', 'Alzheimer Disease-found-SLC40A1', 'Papilledema-upregulated-HGF', 'Papilledema-upregulated-VEGFA', 'SHBG-associated-Triglycerides', 'Triglycerides-associated-SHBG', 'CX3CR1-associated-Atherosclerosis', 'Atherosclerosis-associated-CX3CR1', 'ARID5B-associated-Atherosclerosis', 'Atherosclerosis-associated-ARID5B', 'Arachidonic Acid-involved-Phosphatidylcholines', 'PLA2G4B-belong-Arachidonic Acid', 'PLA2G4B-correlate-Phosphatidylcholines', 'ALOX15B-belong-Arachidonic Acid', 'ALOX15B-correlate-Phosphatidylcholines', 'PDCD4-mitigate-BAX', 'Polycystic Ovary Syndrome-show-Infertility, Female', 'Polycystic Ovary Syndrome-show-Obesity', 'Polycystic Ovary Syndrome-show-INS', 'Polycystic Ovary Syndrome-show-INSR', 'KL-inhibit-IGF1', 'PRKCB-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-PRKCB', 'KL-function by as-Neoplasms', 'PRKCB-associated-Neoplasms', 'Neoplasms-associated-PRKCB', 'REG4-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-REG4', 'REG4-associated-Neoplasms', 'Neoplasms-associated-REG4', 'Neoplasms-inhibit-IGF1', 'CYP27A1-prevent-Retinal Degeneration', 'CYP46A1-prevent-Retinal Degeneration', 'Drug-Related Side Effects and Adverse Reactions-shown-CYP2C19', 'Drug-Related Side Effects and Adverse Reactions-needed-CYP2C19', 'Drug-Related Side Effects and Adverse Reactions-needed-CYP2C9', 'Heart Failure-suffer-Muscular Atrophy', 'CERS1-reduced-Heart Failure', 'CERS1-reduced-Muscular Atrophy', 'CERS5-reduced-Heart Failure', 'CERS5-suffer-Heart Failure', 'CERS5-reduced-Muscular Atrophy', 'Drug-Related Side Effects and Adverse Reactions-diminished-CYP2C19', 'Drug-Related Side Effects and Adverse Reactions-diminished-CYP2D6', 'Cardiac Output, Low-fall-Glucose Metabolism Disorders', 'UCP2-correlated-Diabetes Mellitus', 'UCP3-correlated-Diabetes Mellitus', 'rs659366-correlated-Diabetes Mellitus', 'Genetic Diseases, Inborn-found-Anemia, Aplastic', 'Genetic Diseases, Inborn-found-Uniparental Disomy', 'Genetic Diseases, Inborn-found-Neoplasms', 'Genetic Diseases, Inborn-found-PIGA', 'Genetic Diseases, Inborn-found-DNMT3A', 'DNMT3A-include-Neoplasms', 'Genetic Diseases, Inborn-found-ASXL1', 'ASXL1-include-Neoplasms', 'Ventricular Fibrillation-analysis for-TYR', 'Ventricular Fibrillation-conducted-TYR', 'Ventricular Fibrillation-conducted-MAPK1', 'AQP4-evaluate-ALDH2', 'AQP4-exposed-ALDH2', 'AQP4-overexpressed-Inflammation', 'Inflammation-exposed-ALDH2', 'BCOR-include-Neoplasms', 'BCORL1-include-Neoplasms', 'BAX-indicate-Alzheimer Disease', 'PGF-related-Metabolic Syndrome', 'ABCC9-significant associations with-Sclerosis', 'TNNT1-related-Metabolic Syndrome', 'FABP5-decrease-Neoplasms', 'FABP5-decrease-Adenocarcinoma', 'Sarcopenia-associated-FTO', 'FTO-associated-Sarcopenia', 'Sarcopenia-associated-ESR1', 'ESR1-associated-Sarcopenia', 'Sarcopenia-associated-NOS3', 'NOS3-associated-Sarcopenia', 'Sarcopenia-associated-rs9939609', 'rs9939609-associated-Sarcopenia', 'Sarcopenia-associated-rs4870044', 'rs4870044-associated-Sarcopenia', 'Sarcopenia-associated-rs1799983', 'rs1799983-associated-Sarcopenia', 'Sarcopenia-associated-rs7832552', 'rs7832552-associated-Sarcopenia', 'Inflammation-associated-ZMPSTE24', 'ZMPSTE24-associated-Inflammation', 'Inflammation-associated-LMNA', 'LMNA-associated-Inflammation', 'Hepatitis, Autoimmune-associated-FTCD', 'FTCD-associated-Hepatitis, Autoimmune', 'Glutathione-cause-Neuroblastoma', 'FOXO3-investigate-Ovarian Neoplasms', 'SKP2-investigate-Ovarian Neoplasms', 'TECPR2-implicated-Alzheimer Disease', 'CINP-implicated-Alzheimer Disease', 'FOXO3-considered-Ovarian Neoplasms', 'SKP2-considered-Ovarian Neoplasms', 'NBN-phosphorylated-ATM', 'Immunologic Deficiency Syndromes-contribute-NBN', 'LRRK2-suggest-DNM3', 'Immunologic Deficiency Syndromes-phosphorylated-ATM', 'Neoplasms-phosphorylated-ATM', 'LAMP1-bind-NPC1', 'LAMP1-bind-Cholesterol', 'LAMP2-bind-Cholesterol', 'Cholesterol-bind-NPC1', 'Cholesterol-bind-NPC2', 'LAMP2-represent-Cholesterol', 'NPC1-signal-Cholesterol', 'CALB1-play-Infliximab', 'PVALB-play-Infliximab', 'STN1-include-Glioma', 'CTC1-include-Glioma', 'TERC-include-Glioma', 'Ascorbic Acid-involved-MAPK1', 'CD4-provide-Infections', 'CD8A-provide-Infections', 'MAPK8-involved-Osteoarthritis', 'FURIN-cleave-ACE2', 'PAX8-expressed-Endodermal Sinus Tumor', 'Asthma-cleave-ACE2', 'BCAT1-activate-MTOR', 'BCAT1-activate-PRKAA1', 'BCAT1-activate-SIRT1', 'BCAT1-facilitate-Breast Neoplasms', 'MTOR-facilitate-Breast Neoplasms', 'PRKAA1-facilitate-Breast Neoplasms', 'SIRT1-facilitate-Breast Neoplasms', 'AKT1-reverse-SIRT1', 'AKT1-mediated-SIRT1', 'AKT1-reverse-Doxorubicin', 'FASLG-induce-IL6ST', 'FASLG-activate-Death', 'Death-induce-IL6ST', 'FGF7-derived-Hypothalamic Neoplasms', 'Xeroderma Pigmentosum-coordinate repair through-CDK7', 'SIRT6-correspond-CDKN1A', 'HOXA10-result-Splenomegaly', 'SIRT6-correspond-Heart Arrest', 'KIT-expression of-MITF', 'KIT-be lower in-Pigmentation Disorders', 'Arthritis, Rheumatoid-show-Osteoarthritis', 'Arthritis, Rheumatoid-exhibit-TNFSF11', 'TNFSF11-show-Osteoarthritis', 'Arthritis, Rheumatoid-show-STK17A', 'SOX9-be in-Arthritis, Rheumatoid', 'SOX9-be higher than-Osteoarthritis', 'STK17A-show-Osteoarthritis', 'TP53-downregulated-DCTN6', 'CDKN2A-downregulated-DCTN6', 'Neoplasms-downregulated-DCTN6', 'NCF2-lack-NCF1', 'Granulomatous Disease, Chronic-lack-NCF2', 'Granulomatous Disease, Chronic-lack-NCF1', 'rs1800795-be in-IL6', 'rs1800896-be in-IL10', 'Infarction-include-TARDBP', 'Hemorrhage-include-TARDBP', 'Cerebral Small Vessel Diseases-include-TARDBP', 'Diabetes, Gestational-amounts of-LEPR', 'Diabetes, Gestational-modify-LEPR', 'Diabetes, Gestational-amounts of-INS', 'CERS2-induce apoptosis in-Hepatoblastoma', 'CERS2-induce-Heart Arrest', 'NR3C1-determine-INS', 'IGF1R-associated-Death', 'Death-associated-IGF1R', 'ASPM-associated-Death', 'Death-associated-ASPM', 'IRS2-associated-Death', 'Death-associated-IRS2', 'TTN-associate-TNFRSF25', 'TNFRSF25-associate-TTN', 'Myasthenia Gravis-associate-TNFRSF25', 'TNFRSF25-associate-Myasthenia Gravis', 'UCP2-associated-Death', 'Death-associated-UCP2', 'HDAC4-be in-Chondrosarcoma', 'GLUD1-differentiate-GH1', 'Dwarfism, Pituitary-differentiate-GH1', 'CCL2-play role in-Prostatic Neoplasms', 'CCR2-play role in-Prostatic Neoplasms', 'NR2C2-injected-CCR2', 'NR2C2-enhance-Prostatic Neoplasms', 'Prostatic Neoplasms-injected-CCR2', 'XRCC1-explain-Drug-Related Side Effects and Adverse Reactions', 'XRCC1-explain-Carcinoma, Non-Small-Cell Lung', 'rs2228001-explain-Drug-Related Side Effects and Adverse Reactions', 'rs2228001-explain-Carcinoma, Non-Small-Cell Lung', 'DDAH1-associated-Erectile Dysfunction', 'Erectile Dysfunction-associated-DDAH1', 'DDAH2-associated-Erectile Dysfunction', 'Erectile Dysfunction-associated-DDAH2', 'SOD3-decreased-Blister', 'NOS3-decreased-Blister', 'Erectile Dysfunction-show-DDAH1', 'Erectile Dysfunction-show-DDAH2', 'CFTR-involved-Dinoprostone', 'CFTR-regulate-Dinoprostone', 'Death-compare-IL6', 'Death-compare-CRP', 'ACHE-measured-Alzheimer Disease', 'Alzheimer Disease-associated-Auditory Diseases, Central', 'Auditory Diseases, Central-associated-Alzheimer Disease', 'CAT-associated-Alzheimer Disease', 'Alzheimer Disease-associated-CAT', 'ACHE-associated-Alzheimer Disease', 'Alzheimer Disease-associated-ACHE', 'SNCA-reveal-LRRK2', 'SNCA-reveal-Parkinson Disease', 'Parkinson Disease-caused-SNCA', 'LRRK2-be common genetic cause of-Parkinson Disease', 'Neoplasms-studied-Breast Neoplasms', 'VEGFA-measured-INS', 'PGR-studied-Breast Neoplasms', 'VEGFA-measured-Lipopolysaccharides', 'EREG-studied-Breast Neoplasms', 'CCR4-related-Diabetic Nephropathies', 'NTNG1-server-Diabetic Nephropathies', 'NTNG1-related-Diabetic Nephropathies', 'HGF-server-Diabetic Nephropathies', 'HGF-related-Diabetic Nephropathies', 'Diabetic Nephropathies-related-ISL1', 'Diabetic Nephropathies-server-ISL1', 'SLC2A9-show-Gout', 'ABCG2-show-Gout', 'FOXO3-regulate-Inflammation', 'MUC1-correlate with-CREB3L4', 'MUC1-serve-Breast Neoplasms', 'CREB3L4-serve-Breast Neoplasms', 'AKT1-associated-Brain Infarction', 'Brain Infarction-associated-AKT1', 'AKT1-associated-Aortic Diseases', 'Aortic Diseases-associated-AKT1', 'AKT1-associated-Arteriolosclerosis', 'Arteriolosclerosis-associated-AKT1', 'INS-associated-Arteriolosclerosis', 'Arteriolosclerosis-associated-INS', 'CRP-marker of-Inflammation', 'MT-ND2-associated-Hypertension', 'Hypertension-associated-MT-ND2', 'SLTM-associated-Hypertension', 'Hypertension-associated-SLTM', 'Infections-display-CCL5', 'CD4-implicated-Mastocytosis, Systemic', 'CD8A-implicated-Mastocytosis, Systemic', 'CD40LG-implicated-Mastocytosis, Systemic', 'KLHL22-be elevated in-Breast Neoplasms', 'PPM1D-characterized-ATM', 'PPM1D-characterized-CHEK2', 'PPM1D-characterized-TP53', 'PPM1D-characterized-Neoplasms', 'YAP1-required-Myoepithelioma', 'ATM-include-Neoplasms', 'CHEK2-include-Neoplasms', 'TP53-include-Neoplasms', 'TAFAZZIN-required-Myoepithelioma', 'Neoplasms-inactivate-TP53', 'Neoplasms-inactivate-CDKN2A', 'MYOC-causing-Glaucoma', 'OPTN-causing-Glaucoma', 'OPTN-mediate-Inflammation', 'TOMM40-confirm-rs4420638', 'APOE-confirm-rs4420638', 'APOC1-confirm-rs4420638', 'PCNA-alter-Progeria', 'Progeria-bind-ATR', 'Glucose Metabolism Disorders-improve-Diabetes Mellitus', 'Inflammation-improve-Diabetes Mellitus', 'INS-improve-Diabetes Mellitus', 'GSTM1-modify-APOE', 'GSTM1-modify-rs7412', 'GSTM1-modify-rs429358', 'CAT-detected-APOE', 'CAT-detected-rs7412', 'TLR4-associated-Parkinson Disease', 'Parkinson Disease-associated-TLR4', 'TLR2-associated-Parkinson Disease', 'Parkinson Disease-associated-TLR2', 'TLR4-increased-Parkinson Disease', 'TLR2-be in-Parkinson Disease', 'TLR4-affected-Parkinson Disease', 'TLR4-seem-Parkinson Disease', 'TLR2-affected-Parkinson Disease', 'ATOH1-utilized-Hearing Loss', 'Calcinosis-be greater in-SLC20A2', 'Calcinosis-be greater than-PDGFRB', 'Heart Failure-associated-CD4', 'CD4-associated-Heart Failure', 'Heart Failure-associated-CD8A', 'CD8A-associated-Heart Failure', 'CHI3L1-be potent stimulator of-ACE2', 'CHI3L1-co-opt-HM13', 'CHI3L1-augment-Infections', 'HM13-augment-Infections', 'IL6-associated-Heart Failure', 'Heart Failure-associated-IL6', 'CRP-associated-Heart Failure', 'Heart Failure-associated-CRP', 'Cerebral Infarction-independent predictors of be-Stroke', 'NAMPT-prevent-SIRT1', 'NAMPT-prevent-Obesity', 'Infections-promote-CD4', 'Infections-promote-CCR5', 'CRP-be sensitive for-Death', 'ALB-be sensitive for-Death', 'MAPK1-inhibit-Inflammation', 'ACSS2-modulate-GNG2', 'Progeria-sequester-TNPO1', 'SIRT1-show-Death', 'Endometrial Neoplasms-show-SIRT1', 'Endometrial Neoplasms-show-MAP1LC3A', 'Aortic Aneurysm, Abdominal-confirmed-GNG2', 'GNG2-upregulated-Neoplasms', 'Aortic Aneurysm, Abdominal-confirmed-ACSS2', 'ACSS2-upregulated-Neoplasms', 'Metabolic Syndrome-explore-Inflammation', 'Metabolic Syndrome-measure-CRP', 'Metabolic Syndrome-measure-INS', 'Inflammation-measure-INS', 'MAP1LC3A-inhibited-SIRT1', 'Endometrial Neoplasms-transfected-SIRT1', 'MAP1LC3A-inhibited-Endometrial Neoplasms', 'NAT10-rebalance-TNPO1', 'NAT10-ameliorate-Progeria', 'Progeria-rebalance-TNPO1', 'SYNE1-follow-Carcinogenesis', 'CLEC3B-follow-Carcinogenesis', 'Adenoma-differ-DKK3', 'LTBP3-follow-Carcinogenesis', 'SFRP1-follow-Carcinogenesis', 'SIRT3-outline-PGR', 'Adenoma-differ-SDC2', 'Neoplasms-outline-Carcinogenesis', 'Adenoma-differ-SFRP1', 'Adenoma-differ-SYNE1', 'SIRT3-identified-Neoplasms', 'SIRT3-outline-Carcinogenesis', 'Adenoma-differ-SPATA18', 'Neoplasms-outline-PGR', 'ABCG1-associated-Coronary Artery Disease', 'Coronary Artery Disease-associated-ABCG1', 'GALNT2-associated-Coronary Artery Disease', 'Coronary Artery Disease-associated-GALNT2', 'HMGCR-associated-Coronary Artery Disease', 'Coronary Artery Disease-associated-HMGCR', 'Alzheimer Disease-use-PTPRC', 'Alzheimer Disease-raise-APOE', 'CASP6-cleaved-MAPT', 'CASP6-investigated-Alzheimer Disease', 'Alzheimer Disease-cleaved-MAPT', 'BAG3-regulate-MAPT', 'BAG3-regulate-Proteostasis Deficiencies', 'TBC1D10B-activation of-RAB35', 'TBC1D10B-support-RAB35', 'TBC1D10B-interact-RAB35', 'TBC1D10B-activation of-Myoclonic Epilepsies, Progressive', 'TBC1D10B-support-Myoclonic Epilepsies, Progressive', 'TBC1D10B-interact-Myoclonic Epilepsies, Progressive', 'Lipid Peroxides-identified-MAPK9', 'AR-contribute-Osteoporosis', 'KL-contribute-Osteoporosis', 'KL-act-FGF23', 'Idiopathic Pulmonary Fibrosis-contribute-Fibrosis', 'Idiopathic Pulmonary Fibrosis-contribute-Inflammation', 'KL-contribute-Fibrosis', 'KL-contribute-Inflammation', 'Idiopathic Pulmonary Fibrosis-act-FGF23', 'Fibrosis-act-FGF23', 'Inflammation-act-FGF23', 'CXCL5-secreted-Prostatitis', 'CXCL12-secreted-Prostatitis', 'CXCL1-secreted-Prostatitis', 'CXCL6-secreted-Prostatitis', 'TF-be lower In-Anemia', 'ALB-be lower In-Anemia', 'TRAF6-associated-MYC', 'MYC-associated-TRAF6', 'TRAF6-result-Leukemia, Myeloid', 'FASN-be in-METTL3', 'FASN-mediated-METTL3', 'FASN-decrease-Fatty Acids', 'FASN-abrogate-Fatty Acids', 'METTL3-abrogate-Fatty Acids', 'Neurotoxicity Syndromes-be in-Neuroblastoma', 'Neurotoxicity Syndromes-address-Drug-Related Side Effects and Adverse Reactions', 'Neuroblastoma-address-Drug-Related Side Effects and Adverse Reactions', 'Neurotoxicity Syndromes-address-ACHE', 'Neuroblastoma-address-ACHE', 'CDKN2A-be localized in-Idiopathic Pulmonary Fibrosis', 'SOD2-carried-KLK3', 'SOD2-carried-Prostatic Neoplasms', 'Prostatic Neoplasms-carried-KLK3', 'BPIFB4-result-CXCR4', 'Atherosclerosis-result-CXCR4', 'TMEM106B-identify-GFRA2', 'TMEM106B-replicate-rs36196656', 'rs1990622-identify-GFRA2', 'GFRA2-associated-rs36196656', 'rs36196656-associated-GFRA2', 'GFRA2-replicate-rs36196656', 'Inflammation-link-TNF', 'TNF-used-Cardiovascular Diseases', 'IL10-used-Cardiovascular Diseases', 'IL17A-used-Cardiovascular Diseases', 'NEDD4-identify-NEFH', 'Deafness-identify-NEFH', 'CD8A-used-Carcinoma, Non-Small-Cell Lung', 'CD4-used-Carcinoma, Non-Small-Cell Lung', 'NRG3-implicated-Nervous System Diseases', 'BDNF-implicated-Nervous System Diseases', 'FBN2-glycoprotein of-ELN', 'BGLAP-noticed-PTH', 'Diabetes Mellitus-noticed-PTH', 'GFAP-increase-Alzheimer Disease', 'NOS3-activate-NFE2L2', 'Glucose-increase-NOS3', 'Ascorbic Acid-increase-NOS3', 'Glucose-activate-NFE2L2', 'Ascorbic Acid-activate-NFE2L2', 'PIK3CA-lose-PTEN', 'Neoplasms-present-PIK3CA', 'Neoplasms-lose-PTEN', 'PTEN-present-Ovarian Neoplasms', 'Glucose-trigger-FOXO3', 'SIRT1-enhanced-ACAN', 'SIRT1-reduced-Glycosaminoglycans', 'SIRT1-parallel-Glycosaminoglycans', 'ACAN-reduced-Glycosaminoglycans', 'ACAN-parallel-Glycosaminoglycans', 'SIRT1-impact on-MMRN1', 'SIRT1-suppress-Glycosaminoglycans', 'MMRN1-suppress-Glycosaminoglycans', 'CAMK1D-associated-Infarction', 'Infarction-associated-CAMK1D', 'CDC123-associated-Infarction', 'Infarction-associated-CDC123', 'rs12779790-associated-Infarction', 'Infarction-associated-rs12779790', 'ZFAND2A-exhibit-Drug Hypersensitivity', 'IGF2-upregulate-AQP3', 'H19-bind-IGF2', 'MTOR-impacts of-IGF2', 'MTOR-reverse-IGF2', 'OLA1-respond-NFE2L2', 'H19-upregulate-AQP3', 'OLA1-produce-Glutathione', 'Glutathione-respond-NFE2L2', 'APOE-play-Cardiovascular Diseases', 'APOB-play-Cardiovascular Diseases', 'GGH-reduced-Dwarfism, Pituitary', 'MAPK1-depended-INS', 'Prostatic Hyperplasia-complicated-Diabetes Mellitus, Type 2', 'INS-used-Prostatic Hyperplasia', 'INS-used-Diabetes Mellitus, Type 2', 'INS-complicated-Diabetes Mellitus, Type 2', 'MAPK14-include-MIR22', 'TP53INP1-include-MIR22', 'Huntington Disease-comprise-HDAC4', 'Huntington Disease-comprise-RCOR1', 'Huntington Disease-comprise-RGS2', 'CACNA1E-combat-Neurodegenerative Diseases', 'CACNA1E-combat-Parkinson Disease', 'AXL-decrease during-Calcinosis', 'AXL-enhance-Calcinosis', 'SIRT1-decrease during-Calcinosis', 'SIRT1-enhance-Calcinosis', 'SIRT1-exist-Fibrosis', 'SIRT3-exist-Fibrosis', 'SIRT6-exist-Fibrosis', 'IL1B-develop-Infections', 'CCL4-develop-Infections', 'TNF-develop-Infections', 'CD4-increased-CD40LG', 'CD40LG-increased-Infections', 'CD40LG-be in-Infections', 'CD4-increased-Infections', 'CD4-be in-Infections', 'Myoclonic Epilepsies, Progressive-use-CST3', 'Myoclonic Epilepsies, Progressive-use-CRP', 'TERT-regulate-Neoplasms', 'MAPT-display-CHMP2B', 'SIRT7-defined-ELK4', 'SIRT7-comprise-Neoplasms', 'XPA-confer-Carcinogenesis', 'XPC-confer-Carcinogenesis', 'PRKAA1-appear-SIRT1', 'PRKAA1-appear-Cardiomyopathy, Dilated', 'Cardiomyopathy, Dilated-appear-SIRT1', 'TOMM40-detected-Cardiomyopathy, Dilated', 'TIMM23-detected-Cardiomyopathy, Dilated', 'SIRT3-detected-Cardiomyopathy, Dilated', 'SOD2-detected-Cardiomyopathy, Dilated', 'MT-CO1-detected-Cardiomyopathy, Dilated', 'MT-ND4-detected-Cardiomyopathy, Dilated', 'DTX3L-act-IRF1', 'DTX3L-act-Neoplasms', 'GFAP-contain-VIM', 'GFAP-contain-SLC1A3', 'Inflammation-drive-Neoplasms', 'TP53-include-Anemia', 'SF3B1-include-Anemia', 'NFKB1-drive-Neoplasms', 'SLC1A2-increase-GFAP', 'SLC1A2-increase-Adenomatous Polyposis Coli', 'HIF1A-drive-Neoplasms', 'BFSP1-contribute-Cataract', 'SERPINF1-contribute-Cataract', 'ERCC2-function-ERCC3', 'ERCC2-result-CDK7', 'ERCC2-present-Neoplasms', 'GIP-explain-INS', 'SOD1-play-TP53', 'SOD1-regulate-Death', 'GIP-characterized-Hyperglycemia', 'SOD1-regulate-Neoplasms', 'SOD1-play-Neoplasms', 'Hyperglycemia-explain-INS', 'FABP3-lead-Mitochondrial Diseases', 'Brain Stem Neoplasms-require-FABP3', 'GIP-occur-INS', 'GIP-occur-Glucose', 'INS-occur-Glucose', 'TNFRSF11B-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-TNFRSF11B', 'Eicosanoids-bear-TLR4', 'LEP-of concentrations be-INS', 'LEP-of concentrations be-Glucose', 'HMOX1-associated-BACH1', 'BACH1-associated-HMOX1', 'HMOX1-associated-MIR140', 'MIR140-associated-HMOX1', 'MAPT-involved-Alzheimer Disease', 'NAMPT-associated-SIRT1', 'SIRT1-associated-NAMPT', 'NAMPT-abrogated-SIRT1', 'HES1-increase-Inflammation', 'CYBB-support-CD8A', 'CYBB-support-Vasculitis', 'MIR424-result-MAP2K1', 'MIR424-result-CCNE1', 'MAP2K1-increased-Hemangioma', 'CCNE1-increased-Hemangioma', 'MIR424-increased-Hemangioma', 'Fractures, Open-associated-CRP', 'CRP-associated-Fractures, Open', 'CD8A-be in-Alzheimer Disease', 'CST3-predict-Hip Fractures', 'TNFRSF11B-predict-Hip Fractures', 'PTGS2-associated-Osteoarthritis', 'Osteoarthritis-associated-PTGS2', 'PLA2G4A-associated-Osteoarthritis', 'Osteoarthritis-associated-PLA2G4A', 'rs4140564-associated-Osteoarthritis', 'Osteoarthritis-associated-rs4140564', 'PGC-used-Gastritis, Atrophic', 'Acute Kidney Injury-encode-Neoplasms', 'Neoplasms-regulate-Retinoblastoma', 'Acute Kidney Injury-encode-CDKN2A', 'MAS1L-involved-Neoplasms', 'KAT6B-involved-Neoplasms', 'CDKN2A-regulate-Retinoblastoma', 'CXCL8-follow-TLR4', 'CXCL8-follow-Lipopolysaccharides', 'Lipopolysaccharides-associated-TLR4', 'TLR4-associated-Lipopolysaccharides', 'OGG1-see-Neoplasms', 'OGG1-see-Respiratory Insufficiency', 'ACO2-see-Neoplasms', 'ACO2-see-Respiratory Insufficiency', 'DAXX-use-Breast Neoplasms', 'ATRX-use-Breast Neoplasms', 'BGLAP-correct-PTH', 'BGLAP-measure of-Bone Diseases', 'Bone Diseases-correct-PTH', 'Neoplasms-reduce-Cachexia', 'Fatty Acids, Omega-3-include-JUNB', 'Fatty Acids, Omega-3-suppress-JUNB', 'Fatty Acids, Omega-3-include-BCL2', 'Fatty Acids, Omega-3-decrease-BCL2', 'IL6-associated-DEFB4B', 'DEFB4B-associated-IL6', 'Neoplasms-suppress-JUNB', 'rs1800795-associated-DEFB4B', 'DEFB4B-associated-rs1800795', 'JUNB-reduce-Cachexia', 'Neoplasms-decrease-BCL2', 'BCL2-reduce-Cachexia', 'Neoplasms-include-Fatty Acids, Omega-3', 'BRCA1-associated-Hereditary Breast and Ovarian Cancer Syndrome', 'Hereditary Breast and Ovarian Cancer Syndrome-associated-BRCA1', 'BRCA2-associated-Hereditary Breast and Ovarian Cancer Syndrome', 'Hereditary Breast and Ovarian Cancer Syndrome-associated-BRCA2', 'Fatty Acids, Omega-3-include-Cachexia', 'Fatty Acids, Omega-3-reduce-Cachexia', 'PTX3-associated-Glucose', 'Glucose-associated-PTX3', 'CRP-associated-Glucose', 'Glucose-associated-CRP', 'PTX3-associated-Atherosclerosis', 'Atherosclerosis-associated-PTX3', 'Colorectal Neoplasms-include-GCK', 'Colorectal Neoplasms-include-PCSK1', 'Colorectal Neoplasms-include-MTNR1B', 'Hypertension-increased-RENBP', 'Hypertension-increased-ALB', 'Hypertension-increased-NAGLU', 'KIR2DL4-activate-MBL2', 'KIR2DL4-activate-Infections', 'Chronic Disease-related-Osteoporosis', 'KIR2DL4-activate-Inflammation', 'NLRP3-be essential player in-Chronic Disease', 'NLRP3-be essential player in-Osteoporosis', 'MBL2-activate-Infections', 'NLRP3-repress-SIRT1', 'NLRP3-inhibit-SIRT1', 'Osteogenesis Imperfecta-inhibit-SIRT1', 'PKD2-be milder form with-PKD1', 'Dermatitis, Phototoxic-investigate-MAPK1', 'Dermatitis, Phototoxic-investigate-MAPK8', 'Dermatitis, Phototoxic-caused-MAPK8', 'Neurodegenerative Diseases-involve-CCR5', 'Neurodegenerative Diseases-affect-CXCR4', 'Neurotoxicity Syndromes-focus-Neurodegenerative Diseases', 'Neurotoxicity Syndromes-linked-CCR5', 'CCR5-focus-Neurodegenerative Diseases', 'MAOA-explored-Parkinson Disease', 'MAOB-explored-Parkinson Disease', 'CXCR4-focus-Neurodegenerative Diseases', 'Sepsis-discriminate-Wounds and Injuries', 'Sepsis-identify-Wounds and Injuries', 'ITGA2B-be in-Sepsis', 'Glucose-related-TRPV1', 'PIN1-increase-MAPT', 'Glucose-related-Infliximab', 'Sotos Syndrome-increase-MAPT', 'TRPV1-abolish-SIRT1', 'Infliximab-abolish-SIRT1', 'Parkinson Disease-disrupt-AKT1', 'Parkinson Disease-disrupt-MTOR', 'DNMT3A-mutated-Neoplasms', 'ASXL1-mutated-Neoplasms', 'SERPINA12-increase-INS', 'SERPINA12-increase-Obesity', 'Dipeptides-investigated-REN', 'Dipeptides-investigated-AGT', 'Dipeptides-investigated-Hypertension', 'Hypotension-occur-DNMT3A', 'Hypotension-occur-TET2', 'SERPINA12-increase-ADIPOQ', 'SERPINA12-remain-Glucose Metabolism Disorders', 'GRP-stimulated-Lipopolysaccharides', 'IL6-induced-Lipopolysaccharides', 'RUVBL1-correlate-MTOR', 'Glucose Metabolism Disorders-correlate-Carcinoma, Hepatocellular', 'RUVBL1-correlate-Glucose Metabolism Disorders', 'RUVBL1-found-Carcinoma, Hepatocellular', 'RUVBL1-correlate-Carcinoma, Hepatocellular', 'MTOR-correlate-Carcinoma, Hepatocellular', 'GRP-inhibit-Lipopolysaccharides', 'VIP-inhibit-Lipopolysaccharides', 'Pancreatitis-stained-CCND3', 'Pancreatitis-stained-CDKN2A', 'Pancreatitis-stained-DCTN6', 'Pancreatitis-stained-INS', 'PSEN1-up-regulate-Alzheimer Disease', 'PSEN2-up-regulate-Alzheimer Disease', 'Exanthema-occur-Lymphopenia', 'Lymphopenia-occur-CD4', 'Lymphopenia-occur-CD8A', 'SORBS1-associated-Hypertension', 'Hypertension-associated-SORBS1', 'GCK-associated-Hypertension', 'Hypertension-associated-GCK', 'CCN4-associated-Hypertension', 'Hypertension-associated-CCN4', 'BCL2L1-considered-EEF1A1', 'BCL2L1-considered-EEF2', 'EEF1A1-considered-EEF2', 'HNRNPD-considered-EEF1A1', 'PABPN1-considered-EEF1A1', 'HNRNPD-considered-EEF2', 'PABPN1-considered-EEF2', 'BCL2L1-considered-Osteoarthritis', 'EEF1A1-considered-Osteoarthritis', 'EEF2-considered-Osteoarthritis', 'HNRNPD-considered-Osteoarthritis', 'PABPN1-considered-Osteoarthritis', 'Osteoarthritis-considered-RPL37A', 'Osteoarthritis-considered-FN1', 'BAX-be in-Lupus Erythematosus, Systemic', 'LYZ-correspond-Adenoma, Basophil', 'ELN-correspond-Adenoma, Basophil', 'CRP-influence-Renal Insufficiency, Chronic', 'Infections-derived-CCL5', 'CCL5-derived-Infections', 'PSEN1-reported-Parkinson Disease', 'PSEN2-reported-Parkinson Disease', 'rs699-be in-AGT', 'Glucose-compare-GH1', 'Glucose-compare-VEGFA', 'Osteoporosis-restore-CLU', 'Osteoporosis-carry-TGM2', 'ESR1-analyzed-Breast Neoplasms', 'Obesity-confined-CD8A', 'ALK-emerge-EML4', 'rs1057519783-emerge-ALK', 'rs1057519783-emerge-EML4', 'ALPP-detect-SIRT6', 'ALPP-detect-Osteosarcoma', 'TLR4-increase-Cerebral Hemorrhage', 'MYD88-increase-Cerebral Hemorrhage', 'PSEN1-described-Alzheimer Disease', 'PSEN2-described-Alzheimer Disease', 'Infections-display-IL6', 'IL10-coupled-Drug-Related Side Effects and Adverse Reactions', 'NPY-be in-Hypothalamic Neoplasms', 'Alzheimer Disease-determine-ATXN1', 'Alzheimer Disease-determine-ATXN2', 'Alzheimer Disease-determine-TBP', 'PSEN1-encode-Alzheimer Disease', 'Capsaicin-inhibit-EGFR', 'PSEN2-encode-Alzheimer Disease', 'Capsaicin-inhibit-MAPK1', 'CXCR4-be with-CD4', 'HIV Infections-correlate-CXCR4', 'HIV Infections-correlate-CD4', 'ENHO-increase-NOS3', 'ENHO-restore-Neurologic Manifestations', 'INS-associated-Alzheimer Disease', 'Alzheimer Disease-associated-INS', 'Neurologic Manifestations-increase-NOS3', 'SIRT1-protect-SIRT3', 'SIRT1-protect-Dyslipidemias', 'EGF-inhibit-Skin Diseases', 'FGF1-inhibit-Skin Diseases', 'rs1127379-be in-SFRP1', 'Breast Neoplasms-exhibit-GZMB', 'rs3803164-be in-WNT5B', 'AFP-include-Glucose', 'AFP-include-Polysaccharides', 'CEACAM3-include-Glucose', 'CEACAM3-include-Polysaccharides', 'Neoplasms-include-Glucose', 'Neoplasms-include-Polysaccharides', 'GADD45A-activate-MAP3K4', 'GADD45A-promote-Atrophy', 'Atrophy-activate-MAP3K4', 'Neoplasms-suffer-Gout', 'Neoplasms-suffer-Fibrosis', 'Neoplasms-suffer-Nephrotic Syndrome', 'Neoplasms-suffer-Uremia', 'ATF4-contribute-GADD45A', 'ATF4-contribute-Atrophy', 'APOE-predicted-BDNF', 'Alzheimer Disease-evolve-APOE', 'Alzheimer Disease-predicted-BDNF', 'Alzheimer Disease-convert-APOE', 'SLC17A5-associated-Heart Diseases', 'Heart Diseases-associated-SLC17A5', 'Hemolytic-Uremic Syndrome-indicate-Vascular Calcification', 'SPP1-indicate-Vascular Calcification', 'STOML2-take-MFN2', 'STOML2-take-Alzheimer Disease', 'MFN2-take-Alzheimer Disease', 'KL-cause-WNT1', 'BGLAP-indicate-Vascular Calcification', 'KL-cause-NFE2L2', 'KL-cause-HMOX1', 'KL-cause-Drug-Related Side Effects and Adverse Reactions', 'WNT1-cause-Drug-Related Side Effects and Adverse Reactions', 'Parkinson Disease-implicated-SNCA', 'Parkinson Disease-implicated-LRRK2', 'Parkinson Disease-implicated-GBA', 'Parkinson Disease-implicated-PARK7', 'Fatty Acids, Omega-6-elevate-Dinoprostone', 'PON1-increased-Parkinson Disease', 'PON1-metabolized-Neurodegenerative Diseases', 'ABL2-genetic susceptibility to-Parkinson Disease', 'MARCHF8-identify-NR3C2', 'MIR29B1-identify-NR3C2', 'ADIPOQ-exhibit-INS', 'Alzheimer Disease-correlated-LEP', 'Hypoxia-modulate-TP53', 'TP53-result-Neoplasms', 'Hypoxia-modulate-HIF1A', 'HIF1A-result-Neoplasms', 'rs2075650-be in-TOMM40', 'rs2075650-be in-NECTIN2', 'FLNC-identified-rs746478952', 'FLNC-identified-rs121909335', 'SAR1B-use-Alzheimer Disease', 'APOE-use-Alzheimer Disease', 'rs11948613-use-Alzheimer Disease', 'Death-incidence of-Ovarian Neoplasms', 'TIGIT-increase-Neoplasms', 'HAVCR2-increase-Neoplasms', 'LAG3-increase-Neoplasms', 'Brain Injuries, Traumatic-initiated-Neurodegenerative Diseases', 'Brain Injuries, Traumatic-initiated-Dementia', 'Neurodegenerative Diseases-be with-Dementia', 'MAPT-involved-Brain Injuries, Traumatic', 'MAPT-initiated-Brain Injuries, Traumatic', 'MAPT-involved-Neurodegenerative Diseases', 'MAPT-involved-Dementia', 'FGF19-provide-ESR1', 'FGF19-provide-Breast Neoplasms', 'MIR146A-involved-Inflammation', 'MIR203A-associated-MIR31', 'MIR31-associated-MIR203A', 'MIR19B1-associated-Fractures, Bone', 'Fractures, Bone-associated-MIR19B1', 'MIR203A-associated-Fractures, Bone', 'Fractures, Bone-associated-MIR203A', 'KCNQ1OT1-involved-Lipopolysaccharides', 'MIR31-associated-Fractures, Bone', 'Fractures, Bone-associated-MIR31', 'MIR760-involved-Lipopolysaccharides', 'Diabetes Mellitus-consist-Fractures, Bone', 'Diabetes Mellitus-show-Fractures, Bone', 'Diabetes Mellitus-consist-MIR203A', 'Diabetes Mellitus-consist-MIR31', 'Diabetes Mellitus-consist-MIR19B1', 'HOTAIR-involved-MIR126', 'Calcinosis-involved-HOTAIR', 'MIR34A-involved-Aneurysm', 'MIR34B-involved-Aneurysm', 'GAS5-regulate-CD4', 'CD4-derived-MIR21', 'MIR34C-involved-Aneurysm', 'CD4-derived-HIV Infections', 'GAS5-decrease-CD4', 'GAS5-regulate activation in-CD4', 'GAS5-mediated-MIR21', 'CD4-regulate-HIV Infections', 'GAS5-regulate activation during-HIV Infections', 'HIV Infections-mediated-MIR21', 'H19-contribute-APC', 'MIR34C-implicated-Alzheimer Disease', 'DANCR-suppress differentiation through-PROX1', 'TALAM1-cooperate with-MALAT1', 'TALAM1-guid-Breast Neoplasms', 'TALAM1-guid-Neoplasms', 'MALAT1-guid-Breast Neoplasms', 'MALAT1-guid-Neoplasms', 'Stroke-linked-Coronary Artery Disease', 'Stroke-associated-MIR200B', 'MIR200B-associated-Stroke', 'Stroke-associated-MIR21', 'MIR21-associated-Stroke', 'Alzheimer Disease-protect-Dementia', 'SIRT1-observed-Alzheimer Disease', 'SIRT1-protect-Dementia', 'LILRB1-involved-Hyperglycemia', 'LILRB1-involved-Prediabetic State', 'LILRB1-involved-Diabetes Mellitus', 'MIR21-involved-Hyperglycemia', 'MIR21-involved-Prediabetic State', 'MIR21-involved-Diabetes Mellitus', 'MIR34A-involved-Hyperglycemia', 'MIR34A-involved-Prediabetic State', 'MIR34A-involved-Diabetes Mellitus', 'MIR212-involved-Hyperglycemia', 'MIR212-involved-Prediabetic State', 'MIR212-involved-Diabetes Mellitus', 'MIR132-involved-Hyperglycemia', 'MIR132-involved-Prediabetic State', 'MIR132-involved-Diabetes Mellitus', 'MIR184-involved-Hyperglycemia', 'MIR184-involved-Prediabetic State', 'MIR184-involved-Diabetes Mellitus', 'MIR375-involved-Hyperglycemia', 'MIR375-involved-Prediabetic State', 'MIR375-involved-Diabetes Mellitus', 'FOXP1-upregulated-Lymphoma, B-Cell, Marginal Zone', 'MIR34A-include-SIRT1', 'MIR132-include-SIRT1', 'MIR195-include-SIRT1', 'MIR199B-include-SIRT1', 'MIR204-include-SIRT1', 'SIRT1-affect-Atorvastatin', 'SIRT1-obtained-Coronary Artery Disease', 'Coronary Artery Disease-obtained-Atorvastatin', 'Prostatic Intraepithelial Neoplasia-accompanied-Inflammation', 'Glucose-detect-Neurodegenerative Diseases', 'NFE2L2-cause-Pentosephosphates', 'NFE2L2-cause-Sugar Alcohols', 'Sialic Acids-found-Polysaccharides', 'Sialic Acids-found-Glycolipids', 'Pentosephosphates-show-Sugar Alcohols', 'Pentosephosphates-show-Sorbitol', 'Pentosephosphates-show-Xylitol', 'Blood Glucose-facilitate-Glucose', 'Blood Glucose-promote-INS', 'Pentosephosphates-increase-NFE2L2', 'Sugar Alcohols-increase-NFE2L2', 'INS-facilitate-Glucose', 'Sorbitol-increase-NFE2L2', 'Xylitol-increase-NFE2L2', 'Diabetes Mellitus, Type 2-promote-INS', 'Diabetes Mellitus, Type 2-regulate-Blood Glucose', 'Heparin, Low-Molecular-Weight-compare-Heparin', 'Heparin, Low-Molecular-Weight-compare-Wounds and Injuries', 'Heparin-compare-Wounds and Injuries', 'Diabetes Mellitus, Type 2-facilitate-Glucose', 'Trehalose-withstand-Cold Injury', 'Heparin, Low-Molecular-Weight-associated-Heparin', 'Heparin-associated-Heparin, Low-Molecular-Weight', 'Sugars-withstand-Cold Injury', 'Glutathione-induce-Glucose', 'Heparin, Low-Molecular-Weight-associated-Hemorrhage', 'Hemorrhage-associated-Heparin, Low-Molecular-Weight', 'Glutathione-induce-Ascorbic Acid', 'Hemorrhage-compare-Heparin', 'Hemorrhage-associated-Heparin', 'Heparin-associated-Hemorrhage', 'Polysaccharides-resist-Starch', 'Fatty Acids, Volatile-emerge-Polysaccharides', 'Amino Sugars-be among-AMH', 'Sugars-be among-AMH', 'Glucose-measured-Fluorodeoxyglucose F18', 'Alzheimer Disease-show-Glucose', 'Alzheimer Disease-show-Fluorodeoxyglucose F18', 'Inflammation-accompanied-Glycosaminoglycans', 'Diabetes Mellitus-accompanied-Glycosaminoglycans', 'Glycerol-enhance-Glucose', 'Triglycerides-surge in-Fatty Acids, Nonesterified', 'Triglycerides-incorporation of-Glycerol', 'Triglycerides-enhance-Glycerol', 'Triglycerides-incorporation into-Glucose', 'Glycogen-facilitated-INS', 'Glucose-facilitated-INS', 'Diabetes Mellitus-facilitated-INS', 'Xylitol-anti-inflammatory antiglycemic antiviral and antibacterial properties in-Respiratory Tract Infections', 'Xylitol-demonstrate-Respiratory Tract Infections', 'Heparin-used-Venous Thrombosis', 'Heparin, Low-Molecular-Weight-used-Venous Thrombosis', 'Anthocyanins-associated-Alzheimer Disease', 'Alzheimer Disease-associated-Anthocyanins', 'Bone Neoplasms-associated-Bone Diseases, Metabolic', 'Bone Diseases, Metabolic-associated-Bone Neoplasms', 'Bone Neoplasms-associated-Heparin, Low-Molecular-Weight', 'Heparin, Low-Molecular-Weight-associated-Bone Neoplasms', 'Bone Neoplasms-associated-Heparin', 'Heparin-associated-Bone Neoplasms', 'Digoxin-be with-Isosorbide Dinitrate', 'Digoxin-play-Heart Failure', 'Polysaccharides-range-Sugars', 'Hyaluronic Acid-functionalized-Polysaccharides', 'N-Acetylneuraminic Acid-implicated-Sepsis', 'N-Acetylneuraminic Acid-associated-Sepsis', 'Sepsis-associated-N-Acetylneuraminic Acid', 'Glycosaminoglycans-implicated-Sepsis', 'Glycosaminoglycans-associated-Sepsis', 'Sepsis-associated-Glycosaminoglycans', 'Sugars-promote-Cataract', 'Glycogen-associated-Glucose', 'Glucose-associated-Glycogen', 'Glycogen-phosphorylate-Glucose', 'INS-associated-Glycogen', 'Glycogen-associated-INS', 'INS-phosphorylate-Glucose', 'Oligosaccharides-compared-Polysaccharides', 'Hyperinsulinism-phosphorylate-Glucose', 'Myeloproliferative Disorders-compared-Polysaccharides', 'Glucose-used-Pentosan Sulfuric Polyester', 'Glucose-examine-Pentosan Sulfuric Polyester', 'Glucose-used-Inflammation', 'Glucose-examine-Inflammation', 'Lactose-induce-Neurodegenerative Diseases', 'Lactose-used-Neurodegenerative Diseases', 'Renal Insufficiency-used-Heparin', 'Renal Insufficiency-used-Heparin, Low-Molecular-Weight', 'Glucose-released-Glycogen', 'Glucose-use for-Glutathione', 'Glucose-provide-Neoplasms', 'Gentamicins-require-Aminoglycosides', 'Kidney Diseases-administered-Infections', 'Kidney Diseases-require-Infections', 'Gentamicins-administered-Infections', 'Gentamicins-require-Infections', 'Kidney Diseases-require-Aminoglycosides', 'Primary Ovarian Insufficiency-change-Glycogen', 'Primary Ovarian Insufficiency-change-Glycerol', 'Heparitin Sulfate-sulfated-Polysaccharides', 'Primary Ovarian Insufficiency-change-Triglycerides', 'Venous Thromboembolism-underlie-Cardiovascular Diseases', 'Venous Thromboembolism-underlie-Neoplasms', 'Death-compare-Heparin', 'Myocardial Infarction-Treated-Ischemia', 'Myocardial Infarction-Treated-Enoxaparin', 'Myocardial Infarction-Treated-Heparin', 'Dehydroascorbic Acid-play-Cataract', 'Glucose-measured-Hyperinsulinism', 'Glucose-use-Fluorodeoxyglucose F18', 'Glucose-quantified-INS', 'Fluorodeoxyglucose F18-use-INS', 'Fluorodeoxyglucose F18-reveal-Glucose', 'Fluorodeoxyglucose F18-resemble-Alzheimer Disease', 'Glucose-resemble-Alzheimer Disease', 'Pain-related-Irritable Bowel Syndrome', 'Fructose-reduce-Irritable Bowel Syndrome', 'Fructose-reduce-Pain', 'Lactose-reduce-Irritable Bowel Syndrome', 'Lactose-reduce-Pain', 'Irritable Bowel Syndrome-benefit-Lactose', 'Heparin-treated-Pulmonary Embolism', 'Heparin, Low-Molecular-Weight-treated-Pulmonary Embolism', 'Sugars-vary-Glucose', 'Glucose-generated-Hexosamines', 'OGT-vary-Glucose', 'Glucosamine-impair-Glucose Metabolism Disorders', 'Hexosamines-impair-Glucose Metabolism Disorders', 'Mucopolysaccharidosis III-triggered-Oligosaccharides', 'Ascorbic Acid-lack-IL1B', 'SESN3-siRNA mediated silencing of be-Glucose', 'Leukemia, Promyelocytic, Acute-consist-Daunorubicin', 'Leukemia, Promyelocytic, Acute-consist-Idarubicin', 'Fondaparinux-prevent-Venous Thromboembolism', 'Enoxaparin-be in-Venous Thromboembolism', 'Enoxaparin-prevent-Venous Thromboembolism', 'Venous Thromboembolism-recommend-Heparin', 'Venous Thromboembolism-recommend-Heparin, Low-Molecular-Weight', 'Venous Thromboembolism-recommend-Fondaparinux', 'Heparin, Low-Molecular-Weight-use-Dalteparin', 'Coronary Artery Disease-approved-Venous Thromboembolism', 'Coronary Artery Disease-use-Dalteparin', 'Dalteparin-approved-Venous Thromboembolism', 'Coronary Artery Disease-use-Heparin, Low-Molecular-Weight', 'Heparin, Low-Molecular-Weight-approved-Venous Thromboembolism', 'Neoplasms-incur-Venous Thromboembolism', 'Heparin, Low-Molecular-Weight-incur-Venous Thromboembolism', 'Fondaparinux-incur-Venous Thromboembolism', 'Venous Thromboembolism-admitted-Heparin, Low-Molecular-Weight', 'Venous Thromboembolism-admitted-Fondaparinux', 'Heparin-incur-Venous Thromboembolism', 'Sucrose-increase-ANXA5', 'Glucose-increase-ANXA5', 'Hip Fractures-treated-Enoxaparin', 'Hip Fractures-treated-Heparin', 'CLU-found-Dithiothreitol', 'CLU-supported-Ascorbic Acid', 'Heparin-generate-Thrombocytopenia', 'Enoxaparin-generate-Thrombocytopenia', 'Heparin-with heparin be-Heparin, Low-Molecular-Weight', 'Heparin-incidence of-PF4', 'Heparin-with heparin be-PF4', 'Venous Thromboembolism-use-Heparin', 'Venous Thromboembolism-use-Heparin, Low-Molecular-Weight', 'Acarbose-induced-Sucrose', 'Sucrose-induced-Hypotension', 'Heparin, Low-Molecular-Weight-provide-Enoxaparin', 'Heparin, Low-Molecular-Weight-provide-Dalteparin', 'Enoxaparin-provide-Kidney Diseases', 'Dalteparin-provide-Kidney Diseases', 'Fructose-react-Sugars', 'Fructose-account-Myocardial Infarction', 'Sugars-account-Myocardial Infarction', 'Anthracyclines-inhibit-Neoplasms', 'Anthracyclines-inhibit-Heart Arrest', 'Doxorubicin-inhibit-Neoplasms', 'Doxorubicin-inhibit-Heart Arrest', 'Doxorubicin-include-Anthracyclines', 'Anthracyclines-used-Hodgkin Disease', 'Doxorubicin-used-Hodgkin Disease', 'Glucosamine-evaluate-Osteoarthritis', 'Chondroitin Sulfates-evaluate-Osteoarthritis', 'Enoxaparin-be efficacious alternative to-Heparin', 'Enoxaparin-be efficacious alternative after-Cerebral Infarction', 'Glucosamine-self-administered-Osteoarthritis', 'Chondroitin-self-administered-Osteoarthritis', 'Osteoarthritis-be with-Glucosamine', 'Fluorodeoxyglucose F18-conducted-Glucose', 'Fluorodeoxyglucose F18-assess-Nervous System Diseases', 'Venous Thromboembolism-consist-Hemorrhage', 'Venous Thromboembolism-consist-Heparin', 'Venous Thromboembolism-consist-Fondaparinux', 'Glycosaminoglycans-modulate-Hyaluronic Acid', 'Glucose-used-Neoplasms', 'Glucose-restrain-Neoplasms', 'Glucose-used-Neurodegenerative Diseases', 'Glucose-restrain-Neurodegenerative Diseases', 'Glycosaminoglycans-involved-Atherosclerosis', 'Hyaluronic Acid-involved-Atherosclerosis', 'Heparin-include-Venous Thrombosis', 'Fondaparinux-include-Venous Thrombosis', 'Venous Thrombosis-appear-Hemorrhage', 'Venous Thrombosis-appear-Fondaparinux', 'Venous Thrombosis-appear-Heparin, Low-Molecular-Weight', 'Sorbitol-consist-SORD', 'Aminoglycosides-developed-Infections', 'Aminoglycosides-use-Infections', 'Osteosarcoma-derived-Glutathione', 'N-Acetylneuraminic Acid-transfer-Galactose', 'ST6GAL1-transfer-N-Acetylneuraminic Acid', 'ST6GAL1-transfer-Galactose', 'Fondaparinux-reduce-Enoxaparin', 'Venous Thromboembolism-undergo-Hip Fractures', 'Fondaparinux-reduce-Venous Thromboembolism', 'Fondaparinux-undergo-Hip Fractures', 'Enoxaparin-undergo-Hip Fractures', 'Myocardial Infarction-receive-Heparin, Low-Molecular-Weight', 'Heparin, Low-Molecular-Weight-reduce-Death', 'Myocardial Infarction-receive-Heparin', 'Heparin-unfractionated-Death', 'Heparin-reduce-Death', 'Diabetes Mellitus-established-INS', 'Diabetes Mellitus-established-Glucose', 'Diabetes Mellitus-established-Fructosamine', 'Glucose-become-Neoplasms', 'Diabetes Mellitus-fast-INS', 'Fucose-composed-Trisaccharides', 'Fucose-contain-Trisaccharides', 'Neoplasms-become-Fluorodeoxyglucose F18', 'Fucose-composed-Galactose', 'Glucose-be higher in-Diabetes Mellitus', 'Fucose-composed-Polysaccharides', 'Diabetes Mellitus-fast-Fructosamine', 'Trisaccharides-contain-Galactose', 'Polysaccharides-composed-Trisaccharides', 'Polysaccharides-composed-Galactose', 'Disaccharides-fermented-Glucose', 'Disaccharides-fermented-Galactose', 'LCT-ferment-Disaccharides', 'LCT-fermented-Glucose', 'LCT-fermented-Galactose', 'Heparin, Low-Molecular-Weight-be efficient for-Thromboembolism', 'Heparin-be efficient for-Thromboembolism', 'Heparin-unfractionated-Thromboembolism', 'Thromboembolism-unfractionated-Heparin', 'Idarubicin-used-Leukemia, Myeloid, Acute', 'Anthracyclines-used-Leukemia, Myeloid, Acute', 'Death-use-Heparin', 'Death-use-Heparin, Low-Molecular-Weight', 'Glycosaminoglycans-be in-Chondroitin Sulfates', 'Glycosaminoglycans-increase-CTSK', 'Chondroitin Sulfates-increase-CTSK', 'Diabetes Mellitus-exceed-Fructose', 'Diabetes Mellitus-exceed-Glucose', 'Heparin-exist-Heparin, Low-Molecular-Weight', 'Polysaccharides-present-Venous Thromboembolism', 'Heparin-present-Venous Thromboembolism', 'Venous Thromboembolism-exist-Heparin, Low-Molecular-Weight', 'Anthracyclines-test-Doxorubicin', 'Anthracyclines-be with-Cardiotoxicity', 'Anthracyclines-test-Cardiotoxicity', 'Cardiotoxicity-be with-Doxorubicin', 'Cardiotoxicity-reduce-Doxorubicin', 'Arthritis-removed-Chondroitin Sulfates', 'Idarubicin-combine-Etoposide', 'Arthritis-removed-Keratan Sulfate', 'Idarubicin-combine-Leukemia, Myeloid, Acute', 'Idarubicin-assess-Leukemia, Myeloid, Acute', 'Etoposide-combine-Leukemia, Myeloid, Acute', 'Etoposide-assess-Leukemia, Myeloid, Acute', 'Idarubicin-given-Leukemia, Myeloid, Acute', 'Etoposide-given-Leukemia, Myeloid, Acute', 'Daunorubicin-cause-Doxorubicin', 'Cardiotoxicity-cause-Doxorubicin', 'Leukemia, Myeloid, Acute-cause-Doxorubicin', 'Breast Neoplasms-cause-Doxorubicin', 'Heparitin Sulfate-inhibit-Doxorubicin', 'Familial Mediterranean Fever-inhibit-Heparitin Sulfate', 'Heparitin Sulfate-inhibit-Amyloidosis', 'Etoposide-combined-Daunorubicin', 'Drug-Related Side Effects and Adverse Reactions-combined-Leukemia, Myeloid, Acute', 'Etoposide-combined-Leukemia, Myeloid, Acute', 'Streptozocin-found-Alzheimer Disease', 'Hodgkin Disease-receive-Etoposide', 'Hodgkin Disease-receive-Doxorubicin', 'Hodgkin Disease-receive-Bleomycin', 'Cataract-prepared-Sugars', 'Sugars-found-Glucose', 'Sugars-found-Galactose', 'Sugars-found-N-Acetylneuraminic Acid', 'Sugars-compare-Glucose', 'Sugars-compare-Diabetes Mellitus', 'Glucose-be in-Diabetes Mellitus', 'Glucose-compare-Diabetes Mellitus', 'Sugars-suggest-Cataract', 'Sorbitol-recommended-Lactulose', 'Sorbitol-recommended-Constipation', 'Glucose-considered-Diabetes Mellitus', 'Sorbitol-measured-Nausea', 'HBA1-be sensitive than-Glucose', 'HBA1-be sensitive in-Glucose', 'Lactulose-measured-Nausea', 'HBA1-be sensitive in-Glucose Intolerance', 'Fructose-elicit-Glucose', 'Fructose-elicit-INS', 'Infections-include-Aminoglycosides', 'Infections-include-Amikacin', 'Digitalis Glycosides-provoke-Arrhythmias, Cardiac', 'Glycosides-provoke-Arrhythmias, Cardiac', 'Aminoglycosides-recommended-Gentamicins', 'Aminoglycosides-recommended-Tobramycin', 'Aminoglycosides-recommended-Amikacin', 'Pyelonephritis-recommended-Aminoglycosides', 'Pyelonephritis-recommended-Gentamicins', 'Glucose Metabolism Disorders-use-Fluorodeoxyglucose F18', 'Pyelonephritis-recommended-Tobramycin', 'Pyelonephritis-recommended-Amikacin', 'Glycosaminoglycans-contain-Heparitin Sulfate', 'PYCARD-contain-Heparitin Sulfate', 'Heparitin Sulfate-proposed-Cystinosis', 'Glycosaminoglycans-proposed-Cystinosis', 'Cystic Fibrosis-underglycosylated-Galactose', 'Cystic Fibrosis-underglycosylated-N-Acetylneuraminic Acid', 'Cystic Fibrosis-found-Oligosaccharides', 'N-Acetylneuraminic Acid-contribute-Cystic Fibrosis', 'Glucose-supplemented-Hexosephosphates', 'Cataract-produce-Glucose Metabolism Disorders', 'Cataract-produce-Glucose', 'INS-measured-Hypothermia', 'Glucose-measured-Hypothermia', 'Cataract-produce-Hexosephosphates', 'Glycerol-measured-Hypothermia', 'Fatty Acids-measured-Hypothermia', 'Glucose Metabolism Disorders-supplemented-Hexosephosphates', 'Cataract-supplemented-Hexosephosphates', 'Chondroitin Sulfates-excrete-Mucopolysaccharidosis I', 'Mucopolysaccharidosis I-excrete-Dermatan Sulfate', 'Mucopolysaccharidosis I-excrete-Heparitin Sulfate', 'Cholesterol-include-Voice Disorders', 'Cholesterol-include-Lipid Metabolism Disorders', 'Triglycerides-include-Voice Disorders', 'Triglycerides-include-Lipid Metabolism Disorders', 'Sphingolipids-include-Voice Disorders', 'Sphingolipids-include-Lipid Metabolism Disorders', 'Fatty Acids, Nonesterified-include-Voice Disorders', 'Fatty Acids, Nonesterified-include-Lipid Metabolism Disorders', 'Sterols-applied-Phytosterols', 'Fatty Acids, Unsaturated-associated-Arthritis', 'Arthritis-associated-Fatty Acids, Unsaturated', 'Fatty Acids, Omega-3-associated-Arthritis', 'Arthritis-associated-Fatty Acids, Omega-3', 'Sphingolipids-be structural components of-Lipid Bilayers', 'Hypoxia-increase-Gangliosides', 'Ischemia-increase-Gangliosides', 'G(M1) Ganglioside-induced-Hypoxia-Ischemia, Brain', 'G(M3) Ganglioside-induced-Hypoxia-Ischemia, Brain', 'Fatty Acids, Omega-3-associated-Dementia', 'Dementia-associated-Fatty Acids, Omega-3', 'Fatty Acids, Unsaturated-associated-Dementia', 'Dementia-associated-Fatty Acids, Unsaturated', 'Triglycerides-include-Metabolic Syndrome', 'Rapeseed Oil-related-Death', 'Rapeseed Oil-related-Cardiovascular Diseases', 'Rapeseed Oil-related-Diabetes Mellitus', 'Rapeseed Oil-related-Neoplasms', 'Rapeseed Oil-related-Respiratory Tract Diseases', 'Margarine-related-Death', 'Margarine-related-Cardiovascular Diseases', 'Margarine-related-Diabetes Mellitus', 'Margarine-related-Neoplasms', 'Margarine-related-Respiratory Tract Diseases', 'Sphingomyelins-dysregulated-Alzheimer Disease', 'Cholesterol Esters-dysregulated-Alzheimer Disease', 'Phosphatidylcholines-dysregulated-Alzheimer Disease', 'Phosphatidylethanolamines-dysregulated-Alzheimer Disease', 'Phosphatidylinositols-dysregulated-Alzheimer Disease', 'Triglycerides-dysregulated-Alzheimer Disease', 'Margarine-replace-Rapeseed Oil', 'Rapeseed Oil-replace-Death', 'Diabetes Mellitus-define-Metabolic Syndrome', 'Diabetes Mellitus-used-Metabolic Syndrome', 'Diabetes Mellitus-used-Hypotension', 'Diabetes Mellitus-define-Hypotension', 'Diabetes Mellitus-used-Triglycerides', 'Diabetes Mellitus-define-Triglycerides', 'Diabetes Mellitus-used-Cholesterol', 'Diabetes Mellitus-define-Cholesterol', 'Cholesterol-obtained-Triglycerides', 'Blood Glucose-obtained-Triglycerides', 'Triglycerides-show-Metabolic Syndrome', 'Cholesterol-show-Metabolic Syndrome', 'Fatty Acids-be in-Phospholipids', 'Fatty Acids, Omega-3-include-Cardiovascular Diseases', 'Fatty Acids, Omega-3-include-Fatty Liver', 'Fatty Acids, Omega-3-include-Neurodegenerative Diseases', 'Fatty Acids, Omega-3-include-Diabetic Neuropathies', 'Fatty Acids, Omega-3-include-Neoplasms', 'alpha-Linolenic Acid-indicate-Malnutrition', 'Eicosapentaenoic Acid-indicate-Malnutrition', 'Fatty Acids-associated-Dementia', 'Dementia-associated-Fatty Acids', 'Phospholipids-associated-Dementia', 'Dementia-associated-Phospholipids', 'alpha-Linolenic Acid-associated-Dementia', 'Dementia-associated-alpha-Linolenic Acid', 'Linoleic Acid-associated-Dementia', 'Dementia-associated-Linoleic Acid', '8,11,14-Eicosatrienoic Acid-associated-Dementia', 'Dementia-associated-8,11,14-Eicosatrienoic Acid', 'Arachidonic Acid-associated-Dementia', 'Dementia-associated-Arachidonic Acid', 'Phosphatidylcholines-associated-Renal Insufficiency, Chronic', 'Renal Insufficiency, Chronic-associated-Phosphatidylcholines', 'Triglycerides-associated-Renal Insufficiency, Chronic', 'Renal Insufficiency, Chronic-associated-Triglycerides', 'Ceramides-contain-Acetic Acid', 'Skin Diseases-ingest-Acetic Acid', 'Sphingolipids-known-Ceramides', 'Sphingolipids-prevent-Xerostomia', 'Ceramides-prevent-Xerostomia', 'Rapeseed Oil-used-Sarcopenia', 'Oils-used-Sarcopenia', 'Death-result-Fatty Acids, Unsaturated', 'Death-result-Phospholipids', 'Fatty Acids, Omega-3-reduce-Inflammation', 'Docosahexaenoic Acids-reduce-Inflammation', 'Eicosapentaenoic Acid-reduce-Inflammation', 'Diabetes Mellitus-reduce-Cardiovascular Diseases', 'Fatty Acids, Omega-3-used-Diabetes Mellitus', 'Fatty Acids, Omega-3-reduce-Cardiovascular Diseases', 'Eicosapentaenoic Acid-used-Diabetes Mellitus', 'Eicosapentaenoic Acid-reduce-Cardiovascular Diseases', 'Alzheimer Disease-associated-Docosahexaenoic Acids', 'Docosahexaenoic Acids-associated-Alzheimer Disease', 'Docosahexaenoic Acids-used-Diabetes Mellitus', 'Docosahexaenoic Acids-reduce-Cardiovascular Diseases', 'Triglycerides-feature of-Renal Insufficiency, Chronic', 'Pruritus-have increase-Ceramides', 'Pruritus-increase-Ceramides', 'Phospholipids-be elevated in-Myalgia', 'Phosphatidylcholines-elevated-Myalgia', 'Phosphatidylglycerols-elevated-Myalgia', 'Pruritus-increase-Diglycerides', 'Pruritus-increase-Fatty Acids', 'Pruritus-increase-Phosphatidylcholines', 'Pruritus-increase-Phosphatidylethanolamines', 'Pruritus-increase-Triglycerides', 'Anemia, Sickle Cell-elevate-Docosahexaenoic Acids', 'Fatty Acids, Unsaturated-be with-Alzheimer Disease', 'Anophthalmos-associate-Cholesterol', 'Cholesterol-associate-Anophthalmos', 'Anophthalmos-associate-Triglycerides', 'Triglycerides-associate-Anophthalmos', 'Sarcopenia-observed-INS', 'Sarcopenia-observed-Glucose', 'Sarcopenia-observed-Cholesterol', 'Sarcopenia-observed-Triglycerides', 'Hypotension-reported-Diabetes Mellitus', 'Cholesterol-reported-Diabetes Mellitus', 'Triglycerides-reported-Diabetes Mellitus', 'Triglycerides-predict-Diabetes Mellitus, Type 2', 'Cholesterol-involve-Dyslipidemias', 'Fatty Acids-involve-Dyslipidemias', 'Microvascular Angina-associated-Hypertension', 'Hypertension-associated-Microvascular Angina', 'Microvascular Angina-associated-Inflammation', 'Inflammation-associated-Microvascular Angina', 'Microvascular Angina-associated-Cholesterol', 'Cholesterol-associated-Microvascular Angina', 'Microvascular Angina-associated-Triglycerides', 'Triglycerides-associated-Microvascular Angina', 'Dinoprostone-produced-Arachidonic Acid', 'Arachidonic Acid-produced-MMP1', 'Fatty Acids, Omega-3-associated-Brain Diseases', 'Brain Diseases-associated-Fatty Acids, Omega-3', 'Fatty Acids, Omega-6-associated-Brain Diseases', 'Brain Diseases-associated-Fatty Acids, Omega-6', 'Glycosphingolipids-seen-Parkinson Disease', 'Gangliosides-reduce levels of be-Parkinson Disease', 'Gangliosides-seen-Parkinson Disease', 'Cardiovascular Diseases-associate-Diabetes Mellitus', 'Diabetes Mellitus-associate-Cardiovascular Diseases', 'APOE-associate-Cholesterol', 'Cholesterol-associate-APOE', 'APOE-associate-Triglycerides', 'Triglycerides-associate-APOE', 'APOE-associate-Cardiovascular Diseases', 'Cardiovascular Diseases-associate-APOE', 'APOE-associate-Death', 'Death-associate-APOE', 'APOE-associate-Hypertension', 'Hypertension-associate-APOE', 'APOE-associate-Diabetes Mellitus', 'Diabetes Mellitus-associate-APOE', 'CYP27B1-lead-Calcitriol', 'Glucose-be higher in-Erectile Dysfunction', 'Glucose-diagnosed-Erectile Dysfunction', 'Triglycerides-diagnosed-Erectile Dysfunction', 'Cholesterol-diagnosed-Erectile Dysfunction', 'Cardiovascular Diseases-associate-Triglycerides', 'Triglycerides-associate-Cardiovascular Diseases', 'Hyperuricemia-associated-Cholesterol', 'Cholesterol-associated-Hyperuricemia', 'Hyperuricemia-increase-Triglycerides', 'Hyperuricemia-associated-Triglycerides', 'Triglycerides-associated-Hyperuricemia', 'Triglycerides-increase of-Cholesterol', 'Cholesterol-present-Triglycerides', 'Cholesterol-present-Oils', 'Triglycerides-present-Oils', 'Ceramides-linked-INS', 'Diglycerides-linked-INS', 'Ceramides-measured-INS', 'Diglycerides-measured-INS', 'Lipofuscin-suggested-Ceroid', 'Lipofuscin-suggested-Mitochondrial Diseases', 'Atherosclerosis-exist-Lipofuscin', 'Atherosclerosis-exist-Ceroid', 'Cardiovascular Abnormalities-defined-Inflammation', 'Cardiovascular Abnormalities-defined-Obesity, Abdominal', 'Cardiovascular Abnormalities-defined-Hypertension', 'Cardiovascular Abnormalities-defined-Diabetes Mellitus', 'Cardiovascular Abnormalities-defined-Triglycerides', 'Cardiovascular Abnormalities-defined-Cholesterol', 'CD36-include-Cholesterol', 'CD36-include-Triglycerides', 'Oxysterols-include-Cholesterol', 'Cholesterol Esters-include-Cholesterol', 'Neurologic Manifestations-include-Cholesterol', 'Neurodegenerative Diseases-include-Cholesterol', 'Oxysterols-manifest-Neurologic Manifestations', 'Paresthesia-induce-Capsaicin', 'Fluvastatin-reduce-Cholesterol', 'Paresthesia-induce-Menthol', 'Fluvastatin-activate-SIRT6', 'SIRT6-reduce-Cholesterol', 'SIRT6-suggest-Fatty Liver', 'Fluvastatin-suggest-Fatty Liver', 'Cockayne Syndrome-reduced-Fatty Acids', 'Cockayne Syndrome-reduced-Myristic Acid', 'Thyroid Diseases-between association be-Cholesterol', 'Palm Oil-represent-Fatty Acids', 'Palm Oil-attribute-Cardiovascular Diseases', 'Fatty Acids-attribute-Cardiovascular Diseases', 'Alzheimer Disease-include-Sphingolipids', 'Palm Oil-linked-Fatty Acids', 'Sucrose-have mean latency time than-Fish Oils', 'Sphingomyelins-include-Sphingolipids', 'Niemann-Pick Disease, Type A-associated-Alzheimer Disease', 'Alzheimer Disease-associated-Niemann-Pick Disease, Type A', 'Niemann-Pick Disease, Type A-include-Sphingolipids', 'Sphingolipids-include-Alzheimer Disease', 'Sphingolipids-associated-Alzheimer Disease', 'Alzheimer Disease-associated-Sphingolipids', 'Calcinosis-resemble-Heart Neoplasms', 'Calcinosis-resemble-Thrombosis', 'Polycystic Ovary Syndrome-present-Triglycerides', 'Calcinosis-resemble-Fatty Acids', 'Heart Neoplasms-composed-Fatty Acids', 'Thrombosis-composed-Fatty Acids', 'Calcinosis-resemble-Cholesterol', 'Heart Neoplasms-composed-Cholesterol', 'Thrombosis-composed-Cholesterol', 'Triglycerides-be in-Atherosclerosis', 'Cardiovascular Diseases-classified-Communicable Diseases', 'Fatty Acids, Unsaturated-shown-Docosahexaenoic Acids', 'Fatty Acids, Unsaturated-prevent-Parkinson Disease', 'Fatty Acids, Unsaturated-shown-Parkinson Disease', '3-Hydroxybutyric Acid-synthesized-Fatty Acids', '3-Hydroxybutyric Acid-synthesized-Glucose', 'Fatty Acids-involved-Inflammation', 'Fatty Acids-involved-Pain', 'Fatty Acids, Unsaturated-involved-Pain', 'Oxylipins-target-Cardiovascular Diseases', 'Oxylipins-derived-Fatty Acids, Omega-6', 'Cardiovascular Diseases-target-Oxylipins', 'Cardiovascular Diseases-target-Fatty Acids', 'Oxylipins-derived-Arachidonic Acid', 'Oxylipins-be in-Cardiovascular Diseases', 'Cardiovascular Diseases-derived-Fatty Acids, Omega-6', 'Cardiovascular Diseases-derived-Arachidonic Acid', 'Palmitic Acid-mimic-Obesity', 'Fatty Acids-used-Obesity', 'Fatty Acids-mimic-Obesity', 'CRP-classified-Metabolic Diseases', 'Cholesterol-classified-Metabolic Diseases', 'Triglycerides-classified-Metabolic Diseases', 'Fatty Acids, Unsaturated-contain-Triglycerides', 'Muscular Disorders, Atrophic-detect-Fatty Acids, Unsaturated', 'Muscular Disorders, Atrophic-contain-Triglycerides', 'Linoleic Acid-represent-Alzheimer Disease', 'alpha-Linolenic Acid-represent-Alzheimer Disease', 'Arachidonic Acid-represent-Alzheimer Disease', 'Alzheimer Disease-represent-Docosahexaenoic Acids', 'Metabolic Syndrome-assessed-Sugars', 'Metabolic Syndrome-assessed-Triglycerides', 'Metabolic Syndrome-assessed-Cholesterol', 'Cholesterol-provide-Triglycerides', 'Glucose-provide-Cholesterol', 'Glucose-provide-Triglycerides', 'Delirium-include-alpha-Linolenic Acid', 'Delirium-identified-alpha-Linolenic Acid', 'Delirium-include-Eicosapentaenoic Acid', 'Delirium-identified-Eicosapentaenoic Acid', 'Delirium-include-Linoleic Acid', 'Delirium-identified-Linoleic Acid', 'Phytosterols-mediate-Cholesterol', 'Hypotension-produced-Fatty Acids', 'Phytosterols-supplemented-Cholesterol', 'Phytosterols-supplemented-APOE', 'Cholesterol-be in-APOE', 'Cardiovascular Diseases-include-CRP', 'Cardiovascular Diseases-include-Cholesterol', 'Cardiovascular Diseases-include-Triglycerides', 'Inositol Phosphates-induced-Thromboxane A2', 'Inositol Phosphates-induced-15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid', 'Triglycerides-reduce-Cholesterol', 'Glucose-reduce-Cholesterol', 'Glucose-associated-Olfaction Disorders', 'Olfaction Disorders-associated-Glucose', 'Triglycerides-associated-Olfaction Disorders', 'Olfaction Disorders-associated-Triglycerides', 'Cholesterol-associated-Olfaction Disorders', 'Olfaction Disorders-associated-Cholesterol', 'Kidney Diseases-include-Hypoglycemia', 'Albuminuria-include-Hypoglycemia', 'Kidney Diseases-include-Diabetes Mellitus', 'Albuminuria-include-Diabetes Mellitus', 'INS-include-Hypoglycemia', 'Alzheimer Disease-exhibit-Docosahexaenoic Acids', 'Cholesterol-include-Hypoglycemia', 'Cholesterol-include-Diabetes Mellitus', 'Alzheimer Disease-exhibit-Fatty Acids, Unsaturated', 'Triglycerides-include-Hypoglycemia', 'Triglycerides-include-Diabetes Mellitus', 'Docosahexaenoic Acids-attenuate-Fatty Acids, Omega-3', 'Cholesterol-associated-Ceramides', 'Ceramides-associated-Cholesterol', 'Triglycerides-associated-Ceramides', 'Ceramides-associated-Triglycerides', 'Prediabetic State-associated-Ceramides', 'Ceramides-associated-Prediabetic State', 'Diabetes Mellitus-associated-Ceramides', 'Ceramides-associated-Diabetes Mellitus', 'Olive Oil-related-Oleic Acid', 'Olive Oil-related-Inflammation', 'Inflammation-linked-Oleic Acid', 'SHBG-assessed-Glucose', 'Cholesterol-assessed-Glucose', 'Dinoprostone-synthesized-Arachidonic Acid', 'Arachidonic Acid-synthesized-PTGES', 'Glucose-determined-Cholesterol', 'Glucose-determined-Triglycerides', 'Triglycerides-related-Renal Insufficiency, Chronic', 'Cholesterol-be related to-Renal Insufficiency, Chronic', 'Diabetes Mellitus-display-Triglycerides', 'Diabetes Mellitus-display-Cholesterol', 'CRP-correlated-Cholesterol', 'Hyperlipidemias-associated-Triglycerides', 'Triglycerides-associated-Hyperlipidemias', 'Docosahexaenoic Acids-carry-Fatty Acids, Unsaturated', 'Alzheimer Disease-carry-Fatty Acids, Unsaturated', 'Fatty Acids, Omega-3-relate-Atrophy', 'Cholesterol-relate-Atrophy', 'Glucose-associated-Non-alcoholic Fatty Liver Disease', 'Non-alcoholic Fatty Liver Disease-associated-Glucose', 'Triglycerides-associated-Non-alcoholic Fatty Liver Disease', 'Non-alcoholic Fatty Liver Disease-associated-Triglycerides', 'Cholesterol-associated-Non-alcoholic Fatty Liver Disease', 'Non-alcoholic Fatty Liver Disease-associated-Cholesterol', 'Fatty Acids, Unsaturated-handled-Neoplasms', 'Fatty Acids-polyunsaturated-Neoplasms', 'Fatty Acids-handled-Neoplasms', 'Arthritis, Rheumatoid-correlated-Cholesterol', 'Arthritis, Rheumatoid-correlated-Triglycerides', 'Triglycerides-assessed-Cardiovascular Diseases', 'Triglycerides-infer-Cardiovascular Diseases', 'Cholesterol-infer-Cardiovascular Diseases', 'Cholesterol-assessed-Cardiovascular Diseases', 'Cardiovascular Diseases-identified-Triglycerides', 'Docosahexaenoic Acids-suggested-Diabetes Mellitus', 'Inflammation-quantified-Prostaglandins E', 'Breast Neoplasms-quantified-Prostaglandins E', 'Inflammation-metabolite of-Dinoprostone', 'Inflammation-quantified-Dinoprostone', 'Breast Neoplasms-quantified-Dinoprostone', 'Fatty Acids, Unsaturated-associate-Fatty Acids', 'Fatty Acids-associate-Fatty Acids, Unsaturated', 'Glucose-associate-Fatty Acids', 'Fatty Acids-associate-Glucose', 'Fatty Acids, Unsaturated-rise-Dyslipidemias', 'Fatty Acids, Omega-3-rise-Dyslipidemias', 'Fish Oils-help-Fatty Acids, Omega-3', 'Fish Oils-help-Inflammation', 'Ceramides-catalyze-Sphingomyelins', 'Niemann-Pick Disease, Type A-catalyze-Sphingomyelins', 'Ceramides-lead to-Phosphatidylserines', 'Niemann-Pick Disease, Type A-catalyze-Ceramides', 'Ceramides-lead-Phosphatidylserines', 'Ceramides-create-Anemia', 'Ceramides-lead-Inflammation', 'Fatty Acids, Unsaturated-provide-Docosahexaenoic Acids', 'Fatty Acids, Unsaturated-reveal-Ischemia', 'Ischemia-provide-Docosahexaenoic Acids', 'Diabetes Mellitus-be with-Non-alcoholic Fatty Liver Disease', 'Cholesterol-play-Metabolic Syndrome', 'Triglycerides-play-Metabolic Syndrome', 'Cholesterol-associated-Atherosclerosis', 'Atherosclerosis-associated-Cholesterol', 'Triglycerides-associated-Atherosclerosis', 'Atherosclerosis-associated-Triglycerides', 'Diabetes Mellitus, Type 2-correlated-Triglycerides', 'Diabetes Mellitus, Type 2-correlated-Cholesterol', 'Diabetes Mellitus, Type 2-correlate-Triglycerides', 'Diabetes Mellitus, Type 2-correlate-Cholesterol', 'Triglycerides-be higher compare-Blepharoptosis', 'Triglycerides-be higher in-Blepharoptosis', 'Cholesterol-be higher compare-Blepharoptosis', 'Cholesterol-be higher in-Blepharoptosis', 'Cholesterol-associated-Blepharoptosis', 'Blepharoptosis-associated-Cholesterol', 'Blepharoptosis-associated-Triglycerides', 'Triglycerides-associated-Blepharoptosis', 'Calcitriol-used-Osteoporosis', 'Cholecalciferol-used-Osteoporosis', 'Ergocalciferols-undertaken-Kidney Diseases', 'Cholecalciferol-undertaken-Kidney Diseases', 'Cholesterol-seen-Triglycerides', 'Glucose-accompanied-INS', 'Fatty Acids-decrease-Glucose', 'Triglycerides-decrease-Glucose', 'Fish Oils-increase-Glucose Metabolism Disorders', 'Fatty Acids, Omega-3-increase-Glucose Metabolism Disorders', 'Sphingolipids-investigate-Ceramides', 'Leukemia, Myelogenous, Chronic, BCR-ABL Positive-target-Sphingolipids', 'Cholesterol-increase-Fatty Acids', 'Sphingolipids-manipulate-Ceramides', 'Sphingolipids-increase-Leukemia, Myelogenous, Chronic, BCR-ABL Positive', 'Fatty Acids, Omega-3-associated-Cholesterol', 'Cholesterol-associated-Fatty Acids, Omega-3', 'Fatty Acids, Omega-3-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-Fatty Acids, Omega-3', 'Fatty Acids, Monounsaturated-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-Fatty Acids, Monounsaturated', 'Alzheimer Disease-characterized-Phospholipid Ethers', 'Alzheimer Disease-characterized-Phosphatidylcholines', 'Alzheimer Disease-characterized-Sphingomyelins', 'Alzheimer Disease-characterized-Sterols', 'alpha-Linolenic Acid-derived-Fatty Acids, Omega-3', 'alpha-Linolenic Acid-decrease-Dementia', 'Fatty Acids, Omega-3-decrease-Dementia', 'Eicosapentaenoic Acid-decrease-Dementia', 'Docosahexaenoic Acids-decrease-Dementia', 'Triglycerides-predict-Cholesterol', 'Triglycerides-predict-Death', 'Triglycerides-predict-Cerebrovascular Disorders', 'Cholesterol-predict-Cerebrovascular Disorders', 'Triglycerides-increase-Cholesterol', 'HIV Infections-demonstrate-Triglycerides', 'HIV Infections-increase-Cholesterol', 'Niemann-Pick Disease, Type A-result-Ceramides', 'Niemann-Pick Disease, Type A-coupled-Gangliosides', 'Obesity-increase-Triglycerides', 'Obesity-increase-Cholesterol', 'Cholesterol-assessed-Hyperlipidemias', 'Cholesterol-assessed-Coronary Artery Disease', 'Atorvastatin-assessed-Hyperlipidemias', 'Atorvastatin-assessed-Coronary Artery Disease', 'Atorvastatin-produce-Cholesterol', 'Cholesterol-produce-Coronary Artery Disease', 'Prostaglandins-involved-Osteoarthritis', 'Arachidonic Acid-involved-Osteoarthritis', 'Inflammation-shown-Fatty Acids, Omega-3', 'Inflammation-shown-Docosahexaenoic Acids', 'Docosahexaenoic Acids-estimate-Periodontal Diseases', 'Fatty Acids, Omega-3-shown-Inflammation', 'Eicosapentaenoic Acid-estimate-Periodontal Diseases', 'Cardiovascular Diseases-attributed-Blood Platelet Disorders', 'Cardiovascular Diseases-improve-Blood Platelet Disorders', 'Cardiovascular Diseases-attributed-Triglycerides', 'Cardiovascular Diseases-reduce-Triglycerides', 'Triglycerides-improve-Blood Platelet Disorders', 'Cardiovascular Diseases-attributed-Cholesterol', 'Cholesterol-reduce-Blood Platelet Disorders', 'Cholesterol-improve-Blood Platelet Disorders', 'Seizures-related-INS', 'Seizures-related-Cholesterol', 'Seizures-related-Triglycerides', 'FABP5-result in-Triglycerides', 'FABP5-decrease-Cholesterol', 'FABP5-result-Cholesterol', 'Ceramides-play-Neoplasms', 'Sphingolipids-play-Neoplasms', 'Eicosapentaenoic Acid-associated-Arthritis, Rheumatoid', 'Arthritis, Rheumatoid-associated-Eicosapentaenoic Acid', 'Docosahexaenoic Acids-associated-Arthritis, Rheumatoid', 'Arthritis, Rheumatoid-associated-Docosahexaenoic Acids', 'Triglycerides-found-Obesity', 'Cholesterol-found-Obesity', 'Arachidonic Acid-contribute-Seizures', 'Seizures-contribute-Arachidonic Acid', 'Fatty Acids, Nonesterified-found-Obesity', 'Docosahexaenoic Acids-contribute-Seizures', 'Seizures-contribute-Docosahexaenoic Acids', 'Atherosclerosis-include-Inflammation', 'Cholecalciferol-administer-Hyperparathyroidism, Secondary', 'Leukotrienes-implicated-Inflammation', 'Leukotrienes-implicated-Atherosclerosis', 'Cholesterol-point-Sterols', 'Cholesterol-represent-Inflammation', 'Sterols-represent-Inflammation', 'Triglycerides-met-Cholesterol', 'Coronary Artery Disease-met-Metabolic Syndrome', 'Glucose-met-Cholesterol', 'Coronary Artery Disease-decrease-Glucose', 'Cholesterol-associated-Hypertension', 'Hypertension-associated-Cholesterol', 'Glucose-met-Metabolic Syndrome', 'Coronary Artery Disease-decrease-Triglycerides', 'Triglycerides-met-Metabolic Syndrome', 'Coronary Artery Disease-met-Cholesterol', 'Cholesterol-be all higher among-Paraplegia', 'Triglycerides-be all higher among-Paraplegia', 'Metabolic Syndrome-defined-Obesity', 'Hemorrhage-include-Gemfibrozil', 'Hemorrhage-include-Fluvastatin', 'Death-result-Cardiovascular Diseases', 'Death, Sudden-result-Cardiovascular Diseases', 'Myocardial Infarction-result-Cardiovascular Diseases', 'Thrombosis-result-Cardiovascular Diseases', 'Fish Oils-result-Cardiovascular Diseases', 'Death-result-Fish Oils', 'Death, Sudden-result-Fish Oils', 'Myocardial Infarction-result-Fish Oils', 'Fatty Acids, Omega-3-known-Fish Oils', 'Thrombosis-result-Fish Oils', 'Alzheimer Disease-stem-Fatty Acids, Omega-3', 'Fatty Acids, Omega-3-result-Cardiovascular Diseases', 'Alzheimer Disease-stem-Docosahexaenoic Acids', 'Death-result-Fatty Acids, Omega-3', 'Death, Sudden-result-Fatty Acids, Omega-3', 'Fatty Acids, Omega-3-used-Hyperlipidemias', 'Myocardial Infarction-result-Fatty Acids, Omega-3', 'Fatty Acids, Omega-3-used-Coronary Artery Disease', 'Fatty Acids, Omega-3-used-Hypertension', 'Thrombosis-result-Fatty Acids, Omega-3', 'Sterols-be lower in-Coronary Artery Disease', 'Fish Oils-used-Hyperlipidemias', 'Fish Oils-used-Coronary Artery Disease', 'Fish Oils-used-Hypertension', 'Phospholipids-contain-Docosahexaenoic Acids', 'Phospholipids-associated-Alzheimer Disease', 'Alzheimer Disease-associated-Phospholipids', 'Obesity-measured-Glucose', 'Obesity-measured-Cholesterol', 'Obesity-measured-Triglycerides', 'Docosahexaenoic Acids-beneficial effects in-Amnesia', 'Arachidonic Acid-improve-Brain Damage, Chronic', 'Docosahexaenoic Acids-cognitive dysfunction due-Brain Damage, Chronic', 'Docosahexaenoic Acids-improve-Brain Damage, Chronic', 'Fatty Acids, Essential-discovered-Fatty Acids, Omega-3', 'SIRT1-lead to-Acetates', 'Fatty Acids, Essential-shown-Linoleic Acid', 'Fatty Acids, Essential-shown-Peripheral Nervous System Diseases', 'Fatty Acids-transesterified-Glycerophospholipids', 'Obesity-related-Genetic Diseases, Inborn', 'Polycythemia-related-Genetic Diseases, Inborn', 'Leukocytosis-related-Genetic Diseases, Inborn', 'Dyslipidemias-related-Genetic Diseases, Inborn', 'Cholesterol-associated-Polycythemia', 'Polycythemia-associated-Cholesterol', 'INS-made-Triglycerides', 'Cholesterol-associated-Leukocytosis', 'Leukocytosis-associated-Cholesterol', 'INS-made-Cholesterol', 'Cholesterol-associated-Dyslipidemias', 'Dyslipidemias-associated-Cholesterol', 'Cholesterol-associated-Genetic Diseases, Inborn', 'Genetic Diseases, Inborn-associated-Cholesterol', 'Triglycerides-associated-Obesity', 'Obesity-associated-Triglycerides', 'Triglycerides-associated-Polycythemia', 'Polycythemia-associated-Triglycerides', 'Triglycerides-associated-Leukocytosis', 'Leukocytosis-associated-Triglycerides', 'Triglycerides-associated-Dyslipidemias', 'Dyslipidemias-associated-Triglycerides', 'Triglycerides-associated-Genetic Diseases, Inborn', 'Genetic Diseases, Inborn-associated-Triglycerides', 'Triglycerides-associated-Coronary Artery Disease', 'Coronary Artery Disease-associated-Triglycerides', 'Hypogonadism-associated-INS', 'INS-associated-Hypogonadism', 'Hypogonadism-associated-Cholesterol', 'Cholesterol-associated-Hypogonadism', 'Hypogonadism-associated-Triglycerides', 'Triglycerides-associated-Hypogonadism', 'Musculoskeletal Diseases-done-Obesity', 'Renal Insufficiency-done-Obesity', 'Musculoskeletal Diseases-done-Glucose', 'Renal Insufficiency-done-Glucose', 'Musculoskeletal Diseases-done-Cholesterol', 'Renal Insufficiency-done-Cholesterol', 'Musculoskeletal Diseases-done-Triglycerides', 'Renal Insufficiency-done-Triglycerides', 'Triglycerides-associated-Fatty Acids', 'Fatty Acids-associated-Triglycerides', 'GPT-associated-Glucose', 'Glucose-associated-GPT', 'GPT-associated-Fatty Acids', 'Fatty Acids-associated-GPT', 'GPT-predict-Fatty Acids', 'GPT-associated-Glucose Metabolism Disorders', 'Glucose Metabolism Disorders-associated-GPT', 'GPT-predict-Glucose Metabolism Disorders', 'Glucose Metabolism Disorders-correlate-Triglycerides', 'Glucose-predict-Fatty Acids', 'Glucose Metabolism Disorders-correlate-Fatty Acids, Nonesterified', 'Triglycerides-associated-Glucose Metabolism Disorders', 'Glucose Metabolism Disorders-associated-Triglycerides', 'Triglycerides-predict-Glucose Metabolism Disorders', 'Fatty Acids-predict-Glucose Metabolism Disorders', 'Kidney Diseases-related-Prostaglandins', 'Kidney Diseases-seem-Prostaglandins', 'Kidney Diseases-related-Leukotrienes', 'Kidney Diseases-seem-Leukotrienes', 'Fatty Acids, Monounsaturated-associated-Fatty Acids, Unsaturated', 'Fatty Acids, Unsaturated-associated-Fatty Acids, Monounsaturated', 'Fatty Acids, Monounsaturated-associated-Death', 'Death-associated-Fatty Acids, Monounsaturated', 'Fatty Acids, Monounsaturated-increase-Death', 'Fatty Acids, Unsaturated-increase-Death', 'Fatty Acids, Unsaturated-associated-Death', 'Death-associated-Fatty Acids, Unsaturated', 'Cholesterol-similar-Triglycerides', 'Cholesterol-similar-CRP', 'Cholesterol-be similar between-Progeria', 'Thinness-associated-INS', 'INS-associated-Thinness', 'Fatty Acids-increase-Triglycerides', 'Weight Loss-associated-INS', 'INS-associated-Weight Loss', 'Thinness-associated-Cholesterol', 'Cholesterol-associated-Thinness', 'Fatty Acids-impair-INS', 'Phosphatidylinositols-formed-Diglycerides', 'Thinness-associated-Triglycerides', 'Triglycerides-associated-Thinness', 'Weight Loss-associated-Triglycerides', 'Triglycerides-associated-Weight Loss', 'Triglycerides-impair-INS', 'Hepatitis C-associated-Triglycerides', 'Triglycerides-associated-Hepatitis C', 'Kidney Diseases-related-Inflammation', 'Kidney Diseases-seem-Inflammation', 'Kidney Diseases-inhibit-Prostaglandins', 'Kidney Diseases-inhibit-Leukotrienes', 'IAPP-affinity for-Phospholipids', 'IAPP-show-Phospholipids', 'Albuminuria-include-Obesity, Abdominal', 'INS-associated-Triglycerides', 'Triglycerides-associated-INS', 'IAPP-affinity for-Phosphatidylserines', 'IAPP-show-Phosphatidylserines', 'Cholesterol-result-Ceramides', 'Alzheimer Disease-result-Cholesterol', 'IAPP-show affinity-Alzheimer Disease', 'Alzheimer Disease-result-Ceramides', 'INS-associated-Albuminuria', 'Albuminuria-associated-INS', 'Triglycerides-include-Obesity, Abdominal', 'Cholesterol-include-Obesity, Abdominal', 'Sphingomyelins-protect-Death', 'Ceramides-protect-Death', 'Cholesterol-protect-Death', 'Palmitates-induce-Stearates', 'Glucose-induce-Palmitates', 'Glucose-utilize-Palmitates', 'Glucose-utilize-Stearates', 'Cholesterol-performed-Alzheimer Disease', 'Triglycerides-performed-Alzheimer Disease', 'Atherosclerosis-contain-Cholesterol', 'Atherosclerosis-contain-Oxysterols', 'Gemfibrozil-reduce-Cholesterol', 'Gemfibrozil-reduce-Coronary Artery Disease', 'Diabetes Mellitus-show-Cholesterol', 'Diabetes Mellitus-show-Triglycerides', 'Ceramides-be with-Fatty Acids', 'Ceramides-impact-Glycosphingolipids', 'Fatty Acids-impact-Glycosphingolipids', 'CERS1-regulate-Glycosphingolipids', 'Triglycerides-accompanied-Cholesterol', 'Triglycerides-signify-INS', 'Fibrosis-reduce-Muscular Atrophy', 'Prostaglandins-reduce-Muscular Atrophy', 'Diabetes Mellitus-predict-Coronary Artery Disease', 'Diabetes Mellitus-predict-Cerebral Infarction', 'Hypertension-predict-Coronary Artery Disease', 'Hypertension-predict-Cerebral Infarction', 'Coronary Artery Disease-predict-Cerebral Infarction', 'Cholesterol-predict-Coronary Artery Disease', 'Cholesterol-predict-Cerebral Infarction', 'Triglycerides-predict-Coronary Artery Disease', 'Triglycerides-predict-Cerebral Infarction', 'Alzheimer Disease-of plasma be-Dementia', 'Docosahexaenoic Acids-compare-Dementia', 'Fatty Acids-compare-Dementia', 'Heart Arrest-influence-Ceramides', 'Niemann-Pick Disease, Type A-expressed-Sphingolipids', 'Sphingolipids-compete-Niemann-Pick Disease, Type A', 'Ceramides-be in-Dermatitis, Atopic', 'Dermatitis, Atopic-result-Ceramides', 'Hyperoxia-cause-Lipofuscin', 'Hyperoxia-cause-Ceroid', 'LPL-correlate with-Triglycerides', 'LPL-correlate with-Cholesterol', 'Fish Oils-decrease-Arachidonic Acid', 'Fish Oils-reduce-Triglycerides', 'Fish Oils-decrease-Fatty Acids, Omega-6', 'Thrombosis-prevent-Arrhythmias, Cardiac', 'Fish Oils-decrease-Neoplasms', 'Neoplasms-increase-Arachidonic Acid', 'Fish Oils-decrease-Thrombosis', 'Neoplasms-increase-Fatty Acids, Omega-6', 'Fish Oils-prevent-Arrhythmias, Cardiac', 'Triglycerides-be in-Thrombosis', 'Triglycerides-decrease-Thrombosis', 'Triglycerides-prevent-Arrhythmias, Cardiac', 'Diabetes Mellitus-consist-Cholesterol', 'Diabetes Mellitus-consist-Triglycerides', 'Prostaglandins-prevent-Duodenal Ulcer', 'Prostaglandins-prevent-Ulcer', 'Misoprostol-prevent-Duodenal Ulcer', 'Misoprostol-prevent-Ulcer', 'Hypotension, Orthostatic-related-Cholesterol', 'Hypotension, Orthostatic-related-Triglycerides', 'Misoprostol-dissolve-Cholesterol', 'Misoprostol-dissolve-Gallstones', 'Fatty Acids, Essential-help-Dry Eye Syndromes', 'gamma-Linolenic Acid-help-Dry Eye Syndromes', 'Cholesterol-decrease-Coronary Artery Disease', 'Cholesterol-decrease for-Stroke', 'CRP-associated-Cholesterol', 'Cholesterol-associated-CRP', 'CRP-associated-Triglycerides', 'Triglycerides-associated-CRP', 'CRP-associated-Coagulation Protein Disorders', 'Coagulation Protein Disorders-associated-CRP', 'Glucose-correlate-Cholesterol', 'CRP-associated-Brugada Syndrome', 'Brugada Syndrome-associated-CRP', 'Triglycerides-appear-Cholesterol', 'Triglycerides-be level of-Cholesterol', 'Triglycerides-appear-Coronary Artery Disease', 'COG2-remain-Triglycerides', 'Cholesterol-play-Triglycerides', 'Triglycerides-be in-Glucose', 'Triglycerides-be higher in-Obesity, Abdominal', 'Misoprostol-reduce-Stomach Ulcer', 'Fatty Acids-result-Triglycerides', 'Fatty Acids-cause-Hyperlipidemias', 'Misoprostol-reduce-Hemorrhage', 'Triglycerides-cause-Hyperlipidemias', 'Alprostadil-reduce-Stomach Ulcer', 'Alprostadil-reduce-Hemorrhage', 'Triglycerides-include-Fatty Acids, Essential', 'Cholesterol-include-Fatty Acids, Essential', 'Blood Platelet Disorders-include-Fatty Acids, Essential', 'Arrhythmias, Cardiac-include-Fatty Acids, Essential', 'Misoprostol-reduce-Ulcer', 'Gangliosides-composed-G(M1) Ganglioside', 'Gangliosides-be in-Cataract', 'Gangliosides-composed-Cataract', 'Cataract-composed-G(M1) Ganglioside', 'Cholesterol-indicate-Malnutrition', 'Triglycerides-indicate-Malnutrition', 'Ceramides-assess-Sphingolipids', 'Ceramides-quantified-Sphingolipids', 'Ceramides-assess-Skin Diseases', 'Ceramides-quantified-Skin Diseases', 'Eczema-quantified-Ceramides', 'Ouabain-antagonize-Leukotrienes', 'Gangliosides-determined-Alzheimer Disease', 'Gangliosides-determined-Nervous System Diseases', 'G(M1) Ganglioside-determined-Alzheimer Disease', 'G(M1) Ganglioside-determined-Nervous System Diseases', 'Cholesterol-remove-Fat Necrosis', 'Triglycerides-remove-Fat Necrosis', 'Cholesterol-compared-Coronary Artery Disease', 'Triglycerides-compared-Coronary Artery Disease', 'Glucose-investigate-INS', 'INS-investigate-Triglycerides', 'INS-investigate-Cholesterol', 'Glucose Metabolism Disorders-investigate-INS', 'Glucose-investigate-Triglycerides', 'Glucose-investigate-Cholesterol', 'Alzheimer Disease-find-Gangliosides', 'Alzheimer Disease-find-G(M1) Ganglioside', 'Lipid Peroxides-produce-Epoprostenol', 'Heparin-produce-Epoprostenol', 'Arachidonic Acid-seem-Prostaglandins', 'Hypertension-related-Arachidonic Acid', 'Hypertension-related-Prostaglandins', 'Hypertension-seem-Prostaglandins', 'Cholesterol-studied-Coronary Artery Disease', 'PTH-measured-Hip Fractures', 'Hip Fractures-measured-Calcifediol', 'Calcifediol-maintain-Hyperparathyroidism', 'Hip Fractures-measured-Calcitriol', 'Bone Diseases, Metabolic-measured-Phospholipids', 'Bone Diseases, Metabolic-measured-Phosphatidylinositols', 'Breast Neoplasms, Male-confirm-Coronary Artery Disease', 'Cholesterol-studied-Breast Neoplasms, Male', 'Cholesterol-confirm-Coronary Artery Disease', 'Triglycerides-studied-Breast Neoplasms, Male', 'Triglycerides-confirm-Coronary Artery Disease', 'Prostaglandins-be effective in-Wounds and Injuries', 'Dolichols-affected-Neuronal Ceroid-Lipofuscinoses', 'Lipofuscin-affected-Neuronal Ceroid-Lipofuscinoses', 'Aneurysm-elevate-Cholesterol', 'Optic Neuropathy, Ischemic-elevate-Cholesterol', 'Fatty Acids-examined-Coronary Artery Disease', 'Aneurysm-elevate-Triglycerides', 'Phospholipids-examined-Coronary Artery Disease', 'Linoleic Acid-increase-Docosahexaenoic Acids', 'Optic Neuropathy, Ischemic-elevate-Triglycerides', 'Cod Liver Oil-be with-Docosahexaenoic Acids', 'Cod Liver Oil-be with-Phospholipids', 'Cod Liver Oil-fed-Phospholipids', 'Ventricular Fibrillation-fed-Cod Liver Oil', 'Death, Sudden, Cardiac-fed-Cod Liver Oil', 'Fatty Acids, Unsaturated-tend-Triglycerides', 'Fatty Acids, Unsaturated-tend-Phospholipids', 'Alzheimer Disease-compare-Linoleic Acid', 'Alzheimer Disease-compare-Fatty Acids, Unsaturated', 'Sterols-performed-Cholesterol', 'Sterols-performed-Hyperlipoproteinemia Type II', 'Diabetic Nephropathies-be in-Kidney Failure, Chronic', 'Diabetic Nephropathies-characterized-Cholesterol', 'Diabetic Nephropathies-characterized-Triglycerides', 'Fatty Acids-be indicative of-Werner Syndrome', 'Dementia-be with-Dementia, Vascular', 'Cholesterol-determined-Alzheimer Disease', 'Cholesterol-determined-Dementia, Vascular', 'Cholesterol-determined-Dementia', 'Heart Diseases-incurred-Cholesterol', 'Triglycerides-determined-Alzheimer Disease', 'Triglycerides-determined-Dementia, Vascular', 'Diabetes Mellitus-analyzed-Diabetes Mellitus, Type 2', 'Hypotension-analyzed-Diabetes Mellitus, Type 2', 'Triglycerides-determined-Dementia', 'Triglycerides-analyzed-Diabetes Mellitus, Type 2', 'Cholesterol-analyzed-Diabetes Mellitus, Type 2', 'Fats-be cause of-Coronary Artery Disease', 'Coronary Artery Disease-manifest-Cholesterol', 'Cholesterol-evaluated-Death', 'Cholesterol-evaluated-Cardiovascular Diseases', 'Triglycerides-evaluated-Death', 'Triglycerides-evaluated-Cardiovascular Diseases', 'gamma-Linolenic Acid-found-Cholesterol', "gamma-Linolenic Acid-found-Sjogren's Syndrome", 'gamma-Linolenic Acid-cause-Alcoholism', 'KNG1-stimulate-Dinoprostone', 'KNG1-stimulate-Dinoprost', 'Ascorbic Acid-production of-Dinoprostone', 'Ascorbic Acid-stimulate-Dinoprostone', 'Cholesterol-contents-Phospholipids', 'Dinoprostone-synthesize-Ascorbic Acid', 'Dinoprost-synthesize-Ascorbic Acid', 'Epoprostenol-synthesize-Ascorbic Acid', 'N-Acetylneuraminic Acid-measured-Anemia', 'N-Acetylneuraminic Acid-differ-Anemia', 'Thromboxane A2-synthesize-Ascorbic Acid', 'Cholesterol-measured-Anemia', 'Phospholipids-measured-Anemia', 'Pigmentation Disorders-observe-Lipofuscin', 'Cholesterol-correlated-Glucose', 'Hyperlipoproteinemia Type III-cause-Vascular System Injuries', 'Vascular System Injuries-cause-Atherosclerosis', 'Vascular System Injuries-cause-Coronary Occlusion', 'Vascular System Injuries-cause-Myocardial Infarction', 'Cholesterol-cause-Vascular System Injuries', 'Ergocalciferols-cause-Vascular System Injuries', 'Anserine-include-Dipeptides', 'Dementia-prevent-Dipeptides', 'Chemical and Drug Induced Liver Injury-discuss-Vancomycin', 'Chemical and Drug Induced Liver Injury-discuss-Daptomycin', 'Anserine-improve-Memory Disorders', 'Dipeptides-improve-Memory Disorders', 'GLRX-decrease ratio to-Glutathione', 'GLRX-decrease ratio to-Glutathione Disulfide', 'Insulin Detemir-have make-INS', 'Insulin Glargine-have make-INS', 'Insulin Detemir-achieve protection compare-Insulin Glargine', 'Insulin Glargine-achieve-Weight Gain', 'Insulin Detemir-achieve-Weight Gain', 'Vancomycin-be current mainstay of-Infections', 'Glycopeptides-be current mainstay of-Infections', 'LEP-include-Anorexia', 'Cholecystokinin-include-Anorexia', 'Ghrelin-include-Anorexia', 'Enalapril-used-Hypertension', 'Lisinopril-used-Hypertension', 'Amoxicillin-Potassium Clavulanate Combination-treat-Infections', 'Piperacillin, Tazobactam Drug Combination-show-Vancomycin', 'VEGFA-be with-Ranibizumab', 'Heart Diseases-reported-Heart Failure', 'Heart Failure-reported-Mediastinal Diseases', 'Heart Diseases-reported-Bevacizumab', 'Heart Failure-reported-Bevacizumab', 'Bevacizumab-reported-Mediastinal Diseases', 'Heart Diseases-reported-Cetuximab', 'Heart Failure-reported-Cetuximab', 'Cetuximab-reported-Mediastinal Diseases', 'Psoriasis-influence-Cyclosporine', 'Psoriasis-influence-Adalimumab', 'Psoriasis-influence-Infliximab', 'Psoriasis-influence-Ustekinumab', 'Adalimumab-include-Arthritis, Rheumatoid', 'Rituximab-include-Arthritis, Rheumatoid', 'Cetuximab-act-EGFR', 'Panitumumab-act-EGFR', 'Rituximab-follow-Adalimumab', 'Ranibizumab-occur-Thromboembolism', 'Necrosis-treated-Infliximab', 'TNF-include-Arthritis, Rheumatoid', 'Infliximab-include-Arthritis, Rheumatoid', 'Arthritis, Rheumatoid-be with-Infliximab', 'EGFR-inhibit-Cetuximab', 'EGFR-inhibit-Panitumumab', 'KL-associated-Alzheimer Disease', 'Alzheimer Disease-associated-KL', 'rs9536314-associated-Alzheimer Disease', 'Alzheimer Disease-associated-rs9536314', 'rs9527025-associated-Alzheimer Disease', 'Alzheimer Disease-associated-rs9527025', 'Infliximab-undergo-TNF', 'Trastuzumab-used-Neoplasms', 'Adalimumab-undergo-TNF', 'Cetuximab-used-Neoplasms', 'Bevacizumab-used-Neoplasms', 'Infliximab-undergo-Inflammation', 'Infliximab-undergo-Arthritis, Rheumatoid', 'Infliximab-undergo-Spondylitis, Ankylosing', 'Infliximab-undergo-Arthritis, Psoriatic', 'Infliximab-undergo-Skin Diseases', 'Infliximab-undergo-Psoriasis', 'Adalimumab-undergo-Inflammation', 'Adalimumab-undergo-Arthritis, Rheumatoid', 'Adalimumab-undergo-Spondylitis, Ankylosing', 'Adalimumab-undergo-Arthritis, Psoriatic', 'Adalimumab-undergo-Skin Diseases', 'Adalimumab-undergo-Psoriasis', 'ABO-associated-rs8176719', 'rs8176719-associated-ABO', 'ABO-associated-rs687621', 'rs687621-associated-ABO', 'ABO-associated-rs643434', 'rs643434-associated-ABO', 'ABO-associated-rs505922', 'rs505922-associated-ABO', 'ABO-replicate-rs505922', 'rs1800469-show-Femoral Neck Fractures', 'rs371425292-linked-Alzheimer Disease', 'rs572842823-linked-Alzheimer Disease', 'rs1907240-increase-Pulmonary Disease, Chronic Obstructive', 'rs2257129-increase-Pulmonary Disease, Chronic Obstructive', 'rs61753924-cause-FXYD1', 'Fractures, Bone-carry-rs4988300', 'Fractures, Bone-carry-rs634008', 'Osteoporosis-present-rs4988300', 'Osteoporosis-present-rs634008', 'USF3-lead-rs2908007', 'USF3-lead-rs4531631', 'Osteoporosis-lead-rs2908007', 'PLA2G7-associated-rs7756935', 'rs7756935-associated-PLA2G7', 'PLA2G7-associated-rs1421368', 'rs1421368-associated-PLA2G7', 'PLA2G7-associated-rs1805017', 'rs1805017-associated-PLA2G7', 'PLA2G7-associated-rs4498351', 'rs4498351-associated-PLA2G7', 'MT2A-associated-Breast Neoplasms', 'Breast Neoplasms-associated-MT2A', 'rs1514283-belong-ACE2', 'MT2A-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-MT2A', 'rs4646155-belong-ACE2', 'rs4646176-belong-ACE2', 'rs2285666-belong-ACE2', 'MT2A-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-MT2A', 'rs879922-belong-ACE2', 'rs10636-associated-Breast Neoplasms', 'Breast Neoplasms-associated-rs10636', 'rs10636-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-rs10636', 'rs10636-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-rs10636', 'rs398122403-include-SYNJ1', 'rs1060499619-include-SYNJ1', 'rs1286247510-include-SYNJ1', 'Parkinson Disease, Secondary-include-SYNJ1', 'rs2431697-be early predictor of-rs77375493', 'rs2431697-be early predictor of-JAK2', 'rs2431697-be early predictor of-Primary Myelofibrosis', 'DCLRE1C-harbor-Lymphoproliferative Disorders', 'rs8176719-be in-ABO', 'FOXP3-found-Azoospermia', 'FOXP3-identified-Azoospermia', 'rs429358-show-rs7412', 'rs13217795-associated-Hypotension', 'Hypotension-associated-rs13217795', 'rs2764264-associated-Hypotension', 'Hypotension-associated-rs2764264', 'rs2802292-associated-Hypotension', 'Hypotension-associated-rs2802292', 'rs28942074-affect-Hepatolenticular Degeneration', 'rs1173623580-affect-Hepatolenticular Degeneration', 'rs60431989-affect-Hepatolenticular Degeneration', 'FOXO3-associate-Diabetes Mellitus', 'Diabetes Mellitus-associate-FOXO3', 'rs13217795-associate-Diabetes Mellitus', 'Diabetes Mellitus-associate-rs13217795', 'rs2764264-associate-Diabetes Mellitus', 'Diabetes Mellitus-associate-rs2764264', 'rs2802292-associate-Diabetes Mellitus', 'Diabetes Mellitus-associate-rs2802292', 'rs13220810-associate-Diabetes Mellitus', 'Diabetes Mellitus-associate-rs13220810', 'FOXO3-associated-Hypotension', 'Hypotension-associated-FOXO3', 'rs2066462-associated-rs9651118', 'rs9651118-associated-rs2066462', 'rs4846051-linked-Vision Disorders', 'BCHE-of intron be-rs55781031', 'rs2802292-be in-FOXO3', 'rs405509-associated-APOE', 'APOE-associated-rs405509', 'rs405509-linked-APOE', 'APOE-adjust for-rs405509', 'APOE-predict-Dementia', 'rs440446-cause-Death', 'rs440446-associated-APOE', 'APOE-associated-rs440446', 'rs405509-associated-Dementia', 'Dementia-associated-rs405509', 'rs440446-associated-Dementia', 'Dementia-associated-rs440446', 'rs34637584-injected-rs104893877', 'Death-associated-Brain Edema', 'Brain Edema-associated-Death', 'ABCC8-associated-rs2237982', 'rs2237982-associated-ABCC8', 'ABCC8-associated-rs7105832', 'rs7105832-associated-ABCC8', 'ABCC8-associated-Brain Edema', 'Brain Edema-associated-ABCC8', 'Death-associated-rs2237982', 'rs2237982-associated-Death', 'rs9880404-be with-DIRAS3', 'TERT-assessed-rs2735940', 'DIRAS3-found-rs11928865', 'DIRAS3-found-rs1353828', 'TERT-assessed-rs7712562', 'TERT-assessed-rs2853669', 'DIRAS3-found-rs9814809', 'Xeroderma Pigmentosum-underlie-XPC', 'Diabetes Mellitus, Type 2-detect-rs2736098', 'rs928874-associated-rs1788355', 'rs1788355-associated-rs928874', 'ZBTB21-associated-rs928874', 'rs928874-associated-ZBTB21', 'ZBTB21-associated-rs1788355', 'rs1788355-associated-ZBTB21', 'rs9998212-associated-SPARCL1', 'SPARCL1-associated-rs9998212', 'rs7695558-associated-SPARCL1', 'SPARCL1-associated-rs7695558', 'Prostatic Hyperplasia-diagnosed-Metabolic Syndrome', 'Prostatic Hyperplasia-be with-SRD5A2', 'SRD5A2-diagnosed-Metabolic Syndrome', 'LPA-associated-rs10455872', 'rs10455872-associated-LPA', 'Prostatic Hyperplasia-be with-rs523349', 'rs523349-diagnosed-Metabolic Syndrome', 'LPA-associated-rs3798220', 'rs3798220-associated-LPA', 'rs12470143-diagnosed-Metabolic Syndrome', 'rs2253310-significant effect on-FOXO3', 'Parkinson Disease-crossed-rs421016', 'rs1799998-be in-CYP11B2', 'TERT-reported-TERC', 'TERT-reported-rs12696304', 'TERT-reported-rs3772190', 'TERT-reported-rs16847897', 'TFAM-associated-Alzheimer Disease', 'Alzheimer Disease-associated-TFAM', 'rs1130409-associated-Alzheimer Disease', 'Alzheimer Disease-associated-rs1130409', 'DLX3-attenuate-Osteosarcoma', 'rs1937-associated-Alzheimer Disease', 'Alzheimer Disease-associated-rs1937', 'Atrophy-visualized-Alzheimer Disease', 'rs704180-associated-Atrophy', 'Atrophy-associated-rs704180', 'rs704180-visualized-Alzheimer Disease', 'rs73069071-associated-Atrophy', 'Atrophy-associated-rs73069071', 'rs73069071-visualized-Alzheimer Disease', 'Parkinson Disease-express-rs34637584', 'rs73069071-associated-rs704180', 'rs704180-associated-rs73069071', 'Parkinson Disease-express-rs33939927', 'rs73069071-associated-Sclerosis', 'Sclerosis-associated-rs73069071', 'rs704180-associated-ABCC9', 'ABCC9-associated-rs704180', 'rs73069071-associated-ABCC9', 'ABCC9-associated-rs73069071', 'Olfaction Disorders-reported-Parkinson Disease', 'Olfaction Disorders-reported-LRRK2', 'Olfaction Disorders-reported-rs34637584', 'SOD2-correspond to-rs1141718', 'Olfaction Disorders-reported-rs34778348', 'TSC1-mutation in-Urinary Bladder Neoplasms', 'TSC1-be in-Urinary Bladder Neoplasms', 'rs1205-associated-CRP', 'CRP-associated-rs1205', 'rs3093059-associated-CRP', 'CRP-associated-rs3093059', 'ABCC9-associated-Multifocal Choroiditis', 'Multifocal Choroiditis-associated-ABCC9', 'ABCC9-associated-Atrophy', 'Atrophy-associated-ABCC9', 'rs704180-associated-Multifocal Choroiditis', 'Multifocal Choroiditis-associated-rs704180', 'rs7488080-associated-Atrophy', 'Atrophy-associated-rs7488080', 'CYP19A1-associated-rs2899470', 'rs2899470-associated-CYP19A1', 'CYP19A1-associated-rs10046', 'rs10046-associated-CYP19A1', 'CYP19A1-associated-rs700518', 'rs700518-associated-CYP19A1', 'FUS-lead-rs121909668', 'rs2866943-involved-rs6029959', 'rs2866943-act-rs6029959', 'rs2866943-be in-PTPRT', 'PTPRT-involved-rs6029959', 'PTPRT-act-rs6029959', 'PTPRT-involved-Esophageal Squamous Cell Carcinoma', 'rs2866943-involved-Esophageal Squamous Cell Carcinoma', 'Esophageal Squamous Cell Carcinoma-act-rs6029959', 'rs6929846-associated-rs2116519', 'rs2116519-associated-rs6929846', 'rs6929846-associated-rs146021107', 'rs146021107-associated-rs6929846', 'rs6929846-associated-rs1671021', 'rs1671021-associated-rs6929846', 'Parkinson Disease-identify-rs751478142', 'Parkinson Disease-identify-rs1254004006', 'HSPA9-involved-Carcinogenesis', 'SIRT1-show-rs3740051', 'SIRT1-show-rs2236319', 'SIRT1-show-rs10823108', 'SIRT1-show-rs2273773', 'SIRT1-show-rs1467568', 'rs405509-be in-NECTIN2', 'Sclerosis-show-TMEM106B', 'Sclerosis-show-rs5848', 'Sclerosis-show-rs1990622', 'Death-regard-MDM4', 'Death-regard-rs1563828', 'rs1801133-associated-INS', 'INS-associated-rs1801133', 'rs1801131-associated-INS', 'INS-associated-rs1801131', 'rs1801133-associated-Fatty Liver', 'Fatty Liver-associated-rs1801133', 'rs1801131-associated-Fatty Liver', 'Fatty Liver-associated-rs1801131', 'LRRK2-investigate-rs34637584', 'LRRK2-investigate-Parkinson Disease', 'BDNF-associated-rs1157659', 'rs1157659-associated-BDNF', 'BDNF-associated-rs11030094', 'rs11030094-associated-BDNF', 'BDNF-associated-rs11030108', 'rs11030108-associated-BDNF', 'ADRB2-carry-rs1042718', 'ADRB2-carry-rs1042719', 'CFHR1-accounted-rs6677604', 'BDNF-identified-rs12273363', 'BDNF-identified-rs11030094', 'BDNF-identified-rs925946', 'BDNF-identified-rs1050187', 'BDNF-identified-rs2203877', 'BDNF-identified-rs11030104', 'BDNF-identified-rs11030108', 'BDNF-identified-rs10835211', 'BDNF-identified-rs7934165', 'BDNF-identified-rs908867', 'BDNF-identified-rs1491850', 'BDNF-identified-rs1157459', 'Metabolic Syndrome-exhibit-rs11722228', 'Metabolic Syndrome-exhibit-rs2231142', 'Death-observe-SIRT3', 'Death-observe-rs11555236', 'Death-observe-rs4980329', 'CYP1A1-constructed-rs4646421', 'CYP1A1-constructed-rs4646422', 'CYP1A1-constructed-rs1048943', 'rs2758343-found-rs4880', 'IL36G-achieve-Calcinosis', 'rs11574311-associate-rs2725338', 'rs2725338-associate-rs11574311', 'rs11574311-associate with-Cataract', 'rs11574311-remain-Cataract', 'rs1421085-associated-Obesity', 'Obesity-associated-rs1421085', 'MLH1-stratify-rs1800734', 'MLH1-stratify-rs749072', 'MLH1-stratify-rs13098279', 'MLH1-associated-rs1800734', 'rs1800734-associated-MLH1', 'rs749072-associated-MLH1', 'MLH1-associated-rs749072', 'rs13098279-associated-MLH1', 'MLH1-associated-rs13098279', 'MLH1-associated-Colorectal Neoplasms', 'Colorectal Neoplasms-associated-MLH1', 'rs1800734-associated-Colorectal Neoplasms', 'Colorectal Neoplasms-associated-rs1800734', 'rs749072-associated-Colorectal Neoplasms', 'Colorectal Neoplasms-associated-rs749072', 'rs13098279-associated-Colorectal Neoplasms', 'Colorectal Neoplasms-associated-rs13098279', 'KL-investigate-Kidney Diseases', 'rs11850328-associated-PGF', 'PGF-associated-rs11850328', 'rs2268614-associated-PGF', 'PGF-associated-rs2268614', 'Multiple Sclerosis-explore-rs2522129', 'Multiple Sclerosis-explore-rs2675231', 'Multiple Sclerosis-explore-rs2389963', 'rs10801555-be in-CFH', 'rs376556895-be in-ERCC2', 'Neoplasms-carry-rs758439420', 'Neoplasms-carry-rs376556895', 'rs4644-cover-LGALS3', 'rs4652-cover-LGALS3', 'rs1009977-cover-LGALS3', 'Dementia-associated-MT-CYB', 'MT-CYB-associated-Dementia', 'Atorvastatin-reach-rs445925', 'TAS2R50-predict-Coronary Artery Disease', 'rs20455-predict-Coronary Artery Disease', 'rs1376251-predict-Coronary Artery Disease', 'rs11327935-associate-Fractures, Bone', 'Fractures, Bone-associate-rs11327935', 'rs1800012-associate-Fractures, Bone', 'Fractures, Bone-associate-rs1800012', 'rs3772190-reported-rs2853669', 'rs3772190-reported-rs2736098', 'rs3772190-reported-rs33954691', 'TERC-reported-TERT', 'rs3772190-reported-TERT', 'rs12696304-reported-TERT', 'TERC-reported-rs2853669', 'TERC-reported-rs2736098', 'TERC-reported-rs33954691', 'rs147373451-detected-Leukoencephalopathies', 'rs11670799-detected-Leukoencephalopathies', 'rs10408676-detected-Leukoencephalopathies', 'rs141320511-detected-Leukoencephalopathies', 'rs763602970-detected-Leukoencephalopathies', 'rs115582213-detected-Leukoencephalopathies', 'rs1043994-associated-Leukoencephalopathies', 'Leukoencephalopathies-associated-rs1043994', 'rs10404382-associated-Leukoencephalopathies', 'Leukoencephalopathies-associated-rs10404382', 'rs10423702-associated-Leukoencephalopathies', 'Leukoencephalopathies-associated-rs10423702', 'rs1043997-associated-Leukoencephalopathies', 'Leukoencephalopathies-associated-rs1043997', 'rs7895833-carry-Obesity', 'rs7069102-carry-Obesity', 'rs2273773-carry-Obesity', 'rs8192678-affect-Parkinson Disease', 'rs7895833-show-Obesity', 'rs7069102-show-Obesity', 'rs7895833-carry-Hypertension', 'rs7069102-carry-Hypertension', 'rs2273773-carry-Hypertension', 'rs1799945-known-rs5186', 'Alzheimer Disease-characterize-rs371425292', 'rs1800562-known-rs5186', 'Alzheimer Disease-characterize-rs572842823', 'rs1799945-known-AGTR1', 'rs1800562-known-AGTR1', 'rs1127568-associated-Obesity', 'Obesity-associated-rs1127568', 'rs7604576-associated-Obesity', 'Obesity-associated-rs7604576', 'rs753529-associated-Obesity', 'Obesity-associated-rs753529', 'rs4669573-associated-Alzheimer Disease', 'Alzheimer Disease-associated-rs4669573', 'rs10197851-associated-Alzheimer Disease', 'Alzheimer Disease-associated-rs10197851', 'rs11711889-associated-Alzheimer Disease', 'Alzheimer Disease-associated-rs11711889', 'rs1117750-associated-Alzheimer Disease', 'Alzheimer Disease-associated-rs1117750', 'rs7908652-associated-Alzheimer Disease', 'Alzheimer Disease-associated-rs7908652', 'SOD1-related-Amyotrophic Lateral Sclerosis', 'rs11548779-related-Amyotrophic Lateral Sclerosis', 'rs13048019-correspond-SOD1', 'rs371425292-be with-rs63750526', 'MAPT-develop-Alzheimer Disease', 'rs60369023-include-CDA', 'rs397721610-include-CDA', 'rs2072671-include-CDA', 'Neoplasms-include-CDA', 'Pulmonary Disease, Chronic Obstructive-associated-rs2245121', 'rs2245121-associated-Pulmonary Disease, Chronic Obstructive', 'Pulmonary Disease, Chronic Obstructive-associated-rs911887', 'rs911887-associated-Pulmonary Disease, Chronic Obstructive', 'Pulmonary Disease, Chronic Obstructive-associated-rs6413520', 'rs6413520-associated-Pulmonary Disease, Chronic Obstructive', 'Pulmonary Disease, Chronic Obstructive-associated-rs721917', 'rs721917-associated-Pulmonary Disease, Chronic Obstructive', 'Hypertension-associated-rs1800562', 'rs1800562-associated-Hypertension', 'Diabetes Mellitus-associated-rs1800562', 'rs1800562-associated-Diabetes Mellitus', 'rs121434416-created-PNPLA6', 'rs121434415-created-PNPLA6', 'rs121913050-compared-rs121913049', 'rs121913050-compared-ERCC4', 'ERCC4-compared-rs121913049', 'ERCC4-compared-Xeroderma Pigmentosum', 'rs121913050-compared-Xeroderma Pigmentosum', 'Xeroderma Pigmentosum-compared-rs121913049', 'Macular Degeneration-target-Retinal Dystrophies', 'rs12272004-associated-rs3135506', 'rs3135506-associated-rs12272004', 'rs12272004-associated-APOA5', 'APOA5-associated-rs12272004', 'rs3135506-be in-APOA5', 'rs12272004-associated-Triglycerides', 'Triglycerides-associated-rs12272004', 'rs1801133-associated-Urinary Bladder Neoplasms', 'Urinary Bladder Neoplasms-associated-rs1801133', 'rs1801131-associated-Urinary Bladder Neoplasms', 'Urinary Bladder Neoplasms-associated-rs1801131', 'rs1805087-associated-Urinary Bladder Neoplasms', 'Urinary Bladder Neoplasms-associated-rs1805087', 'Urinary Bladder Neoplasms-denote-rs1801133', 'rs3771362-detected-rs7595412', 'PLCL1-detected-rs7595412', 'KL-implicate-Osteoarthritis', 'rs1805007-associated-Melanoma', 'Melanoma-associated-rs1805007', 'rs10040427-found-Cardiomyopathies', 'rs72552732-found-Cardiomyopathies', 'rs1805008-associated-Melanoma', 'Melanoma-associated-rs1805008', 'rs1805009-associated-Melanoma', 'Melanoma-associated-rs1805009', 'rs77300588-found-Cardiomyopathies', 'rs774792831-found-Cardiomyopathies', 'rs28383481-found-Cardiomyopathies', 'rs2230500-draw-PRKCH', 'PRKCH-be with-Stroke, Lacunar', 'rs2230500-draw-Stroke, Lacunar', 'FOXO1-include-Death', 'rs10507486-include-Death', 'rs4943794-include-Death', 'ACE-decrease-Aneurysm', 'ACE-decrease-Cardiovascular Diseases', 'rs699-decrease-Cardiovascular Diseases', 'MT-CYB-associated-Obesity', 'Obesity-associated-MT-CYB', 'rs199951903-associated-Obesity', 'Obesity-associated-rs199951903', 'MFSD11-genotyped-rs5351', 'Familial Mediterranean Fever-play-Coronary Artery Disease', 'Coronary Artery Disease-affected-Myocardial Infarction', 'rs28940578-affected-Myocardial Infarction', 'Coronary Artery Disease-play-rs28940578', 'rs28940579-encoded-Myocardial Infarction', 'VEGFA-be in-Giant Cell Arteritis', 'rs1204100257-change-TGFBI', 'Corneal Dystrophies, Hereditary-change-TGFBI', 'Corneal Dystrophies, Hereditary-change-rs121909210', 'rs1800562-modify-rs1799945', 'rs1800562-be in-HFE', 'rs1800562-be important causes of-Hemochromatosis', 'rs1800562-modify-rs1800730', 'HFE-modify-rs1799945', 'HFE-modify-rs1800730', 'rs1799945-detect-Hemochromatosis', 'rs9536314-harbor-rs9527025', 'KL-harbor-rs9536314', 'rs61754278-lie-CYP17A1', 'rs104894139-lie-CYP17A1', 'Neuroblastoma-overexpress-rs104893877', 'Neuroblastoma-overexpress-rs104893878', 'rs104893877-expressed-rs104893878', 'SIRT1-described-Kidney Diseases', 'SIRT1-described-Diabetic Nephropathies', 'TP53-associated-Leukemia, Myeloid', 'Leukemia, Myeloid-associated-TP53', 'TP53-associated-Myelodysplastic Syndromes', 'Myelodysplastic Syndromes-associated-TP53', 'TP53-improve-Myelodysplastic Syndromes', 'TP53-improve-Leukemia, Myeloid, Acute', 'TP53-associated-Leukemia, Myeloid, Acute', 'Leukemia, Myeloid, Acute-associated-TP53', 'TP53-drive-Myelodysplastic Syndromes', 'TP53-drive-Leukemia, Myeloid, Acute', 'Neoplasms-show-Myelodysplastic Syndromes', 'Neoplasms-show-Leukemia, Myeloid, Acute', 'TP53-show-Myelodysplastic Syndromes', 'TP53-show-Leukemia, Myeloid, Acute', 'Neoplasms-show-TP53', 'TP53-treat-Myelodysplastic Syndromes', 'TP53-treat-Leukemia, Myeloid, Acute', 'Myelodysplastic Syndromes-treat-TP53', 'Leukemia, Myeloid, Acute-treat-TP53', 'TP53-devise-Leukemia, Myeloid', 'TP53-devise-Neoplasms', 'INS-induced-Obesity', 'INS-normalize-Diabetes Mellitus', 'ACKR3-implicated-Neoplasms', 'ACKR3-implicated-Inflammation', 'PRPS2-implicated-Leukemia', 'ACKR3-implicated-Cardiovascular Diseases', 'PRPS2-implicated-Colorectal Neoplasms', 'PRPS2-implicated-Carcinoma, Hepatocellular', 'Diabetes Mellitus-caused-INS', 'Brain Diseases-cause-Heredodegenerative Disorders, Nervous System', 'CTSB-result in-Brain Diseases', 'CTSB-cause-Heredodegenerative Disorders, Nervous System', 'Death-predict-Memory Disorders', 'NEFL-predict-Death', 'Death-be in-Nervous System Diseases', 'NEFL-linked-Death', 'NEFL-linked-Nervous System Diseases', 'Heart Failure-increase-CCL17', 'CCL17-correlate-Heart Diseases', 'Ataxia-associated-Death', 'Death-associated-Ataxia', 'Adenomatous Polyposis Coli-associated-Death', 'Death-associated-Adenomatous Polyposis Coli', 'H19-associated-Death', 'Death-associated-H19', 'IRF1-attributed-Obesity', 'IRF1-attributed-Diabetes Mellitus', 'Death-fulfil-Sarcopenia', 'Death-fulfil-H19', 'Adenomatous Polyposis Coli-used-Death', 'H19-used-Death', 'Cataract-exacerbate-Fibrosis', 'Cataract-provide-NGF', 'Alzheimer Disease-associated-Chemical and Drug Induced Liver Injury', 'Chemical and Drug Induced Liver Injury-associated-Alzheimer Disease', 'Fibrosis-provide-NGF', 'Alzheimer Disease-associated-MAPT', 'MAPT-associated-Alzheimer Disease', 'HEYL-associate-Fever', 'Fever-associate-HEYL', 'HEYL-associate-Pneumonia', 'Pneumonia-associate-HEYL', 'Neurodegenerative Diseases-assess-Dementia', 'HEYL-associate-Cough', 'Cough-associate-HEYL', 'Acute Coronary Syndrome-found-Cholesterol', 'MAPT-differentiate-Neurodegenerative Diseases', 'MAPT-show potential in-Alzheimer Disease', 'Cardiovascular Diseases-confined-Inflammation', 'Death-confined-Inflammation', 'Chronic Kidney Disease-Mineral and Bone Disorder-be in-Osteoporotic Fractures', 'Hypocalcemia-treated-Denosumab', 'Chronic Kidney Disease-Mineral and Bone Disorder-treated-Denosumab', 'Osteoporotic Fractures-treated-Denosumab', 'Amyloidosis-perform-Inflammation', 'MAPT-associated-Inflammation', 'Inflammation-associated-MAPT', 'Amyloidosis-perform-MAPT', 'LEP-involved-Obesity', 'RGN-compare-Cataract', 'RGN-compare-AIDS-Related Complex', 'ELOVL2-disturb-Mitochondrial Diseases', 'Cardiovascular Diseases-be with-Plaque, Atherosclerotic', 'Mitochondrial Diseases-include-Alzheimer Disease', 'Nerve Degeneration-include-Alzheimer Disease', 'SIRT7-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-SIRT7', 'SIRT7-associated-Obesity', 'Obesity-associated-SIRT7', 'SIRT7-associated-Osteoporosis', 'Osteoporosis-associated-SIRT7', 'SIRT7-associated-Neoplasms', 'Neoplasms-associated-SIRT7', 'Cartilage Diseases-alleviate-Pain', 'Cartilage Diseases-use-CDKN2A', 'Pain-use-CDKN2A', 'Werner Syndrome-associated-TOP1', 'TOP1-associated-Werner Syndrome', 'AR-include-Prostatic Neoplasms', 'Kidney Diseases-measured-Death', 'Periodontitis-prevent-Prostatic Neoplasms', 'Vancomycin-associated-Kidney Diseases', 'Kidney Diseases-associated-Vancomycin', 'Vancomycin-induced-Kidney Diseases', 'Vancomycin-measured-Kidney Diseases', 'KLK3-prevent-Prostatic Neoplasms', 'Vancomycin-associated-Death', 'Death-associated-Vancomycin', 'Vancomycin-measured-Death', 'Vancomycin-restart-Death', 'Kidney Diseases-induced-Vancomycin', 'ETS1-alleviate-Lung Diseases', 'Epilepsy, Temporal Lobe-lead-Epilepsy', 'Epilepsy, Temporal Lobe-found-MAPT', 'Epilepsy-lead-MAPT', 'INS-manifested-Diabetes Mellitus, Type 2', 'NONO-observed-Neoplasms', 'NONO-observed-Adenocarcinoma', 'NONO-observed-Melanoma', 'NONO-observed-Colonic Neoplasms', 'INS-accelerated-Obesity', 'INS-accompanied-Lipoma', 'OPRM1-determined-Constipation', 'Basal Ganglia Diseases-linked-Nervous System Diseases', 'NEFL-be potent indicator of-Basal Ganglia Diseases', 'APOE-associated-Parkinson Disease', 'Parkinson Disease-associated-APOE', 'APOE-associated-Parkinsonian Disorders', 'Parkinsonian Disorders-associated-APOE', 'Delirium-be in-Hip Fractures', 'Pulmonary Atresia-culminate-Primary Ovarian Insufficiency', 'SH2B1-play role in-Neurodegenerative Diseases', 'SH2B1-play role in-Parkinson Disease', 'Diabetes Mellitus-of treatment be-Neoplasms', 'Cardiovascular Diseases-assess-rs2016347', 'Hypertension-assess-rs2016347', 'Hypercholesterolemia-assess-rs2016347', 'CDH1-promote-Inflammation', 'SIRT2-identified-Inflammation', 'SIRT2-identified-Neurodegenerative Diseases', 'SIRT2-identified-Neoplasms', 'Inflammation-trigger-Neurodegenerative Diseases', 'SNCA-oligomerize-Inflammation', 'SNCA-oligomerize-Neurodegenerative Diseases', 'Muscular Atrophy-induce-Adenocarcinoma of Lung', 'Ginsenosides-prevent-Tauopathies', 'Tauopathies-use-Ginsenosides', 'Tauopathies-identify-Ginsenosides', 'SHBG-evaluate-Muscular Dystrophy, Duchenne', 'SHBG-evaluate-Femoral Neck Fractures', 'Diabetes Mellitus, Type 2-linked-Alzheimer Disease', 'INS-linked-Diabetes Mellitus, Type 2', 'INS-linked-Alzheimer Disease', 'INS-linked-Neurodegenerative Diseases', 'AQR-demonstrate-Diabetes Mellitus, Type 2', 'Ceramides-result-Niemann-Pick Disease, Type A', 'AQR-demonstrate-Metabolic Syndrome', 'GLO1-induce-Neoplasms', 'GLO1-related-Neoplasms', 'Craniofacial Abnormalities-treat-Bone Diseases', 'Craniofacial Abnormalities-demonstrate-KDM5D', 'KDM5D-treat-Bone Diseases', 'PTEN-deleted-Neoplasms', 'BNIP3-mitigate-Inflammation', 'BNIP3-mitigate-Atrophy', 'Arthritis, Rheumatoid-be with-Sarcopenia', 'Glycogen Storage Disease Type II-exacerbated-Immunologic Deficiency Syndromes', 'AKT1-exacerbated-Immunologic Deficiency Syndromes', 'Genetic Diseases, Inborn-overlap-Hyperbilirubinemia', 'Genetic Diseases, Inborn-overlap-Kidney Diseases', 'Genetic Diseases, Inborn-overlap-Diabetes Mellitus', 'Genetic Diseases, Inborn-overlap-Pain Insensitivity, Congenital', 'Genetic Diseases, Inborn-overlap-PMP22', 'MTOR-become-Neoplasms', 'AKT1-offer-Choroiditis', 'MTOR-become-Nervous System Diseases', 'AKT1-offer-Glycogen Storage Disease Type II', 'Diabetes Mellitus-increase-Kidney Failure, Chronic', 'Hypercholesterolemia-increase-Kidney Failure, Chronic', 'MIF-interact-Diabetes Mellitus', 'MIF-interact-Hypercholesterolemia', 'MIF-interact-Kidney Failure, Chronic', 'MIF-increase-Kidney Failure, Chronic', 'rs755622-interact-Diabetes Mellitus', 'rs755622-interact-Hypercholesterolemia', 'rs755622-interact-Kidney Failure, Chronic', 'rs755622-increase-Kidney Failure, Chronic', 'Inflammation-include-AGER', 'Neoplasms-include-AGER', 'Atrial Remodeling-inhibit-Atrial Fibrillation', 'Mitochondrial Diseases-play-Osteoporosis', 'Atrial Fibrillation-presence of be-Death', 'Sarcopenia-impair-Muscular Diseases', 'Sarcopenia-impair-Glucose', 'MAPT-undergo-Alzheimer Disease', 'Muscular Atrophy-investigated-MSTN', 'Cachexia-investigated-MSTN', 'Pain-measure-CRP', 'Leukocytosis-measure-CRP', 'Cholesterol-transport-Alzheimer Disease', 'Cholesterol-transport-Dementia', 'Cholesterol-associated-Heredodegenerative Disorders, Nervous System', 'Heredodegenerative Disorders, Nervous System-associated-Cholesterol', 'Cholesterol-associated-Parkinson Disease, Secondary', 'Parkinson Disease, Secondary-associated-Cholesterol', 'Cholesterol-associated-Huntington Disease', 'Huntington Disease-associated-Cholesterol', 'Heart Failure-associated-Immunologic Deficiency Syndromes', 'Immunologic Deficiency Syndromes-associated-Heart Failure', 'ADCY4-associated-Immunologic Deficiency Syndromes', 'Immunologic Deficiency Syndromes-associated-ADCY4', 'ADCY4-alleviate-Fibrosis', 'ADCY4-alleviate-Calcinosis', 'Stroke-improve-Heart Diseases', 'ADCY4-increase-Stroke', 'ADCY4-improve-Heart Diseases', 'Mitochondrial Diseases-enhance-INS', 'Mitochondrial Diseases-disturb-Fatty Acids', 'Atrophy-support-Inflammation', 'Atrophy-exacerbate-Obesity', 'Atrophy-exacerbate-INS', 'Coronary Artery Disease-serve-Death', 'Alzheimer Disease-labeled-NEFH', 'Cholesterol-serve-Death', 'Atrophy-evaluate-Alzheimer Disease', 'rs7038172-transition of-Alzheimer Disease', 'rs7038172-accelerate-Alzheimer Disease', 'rs7038172-transition to-Dementia', 'rs7038172-accelerate-Dementia', 'Amyloidosis-be with-Tauopathies', 'Amyloidosis-be with-MAPT', 'Amyloidosis-result-MAPT', 'MAPT-result-Tauopathies', 'Nerve Degeneration-potential mechanisms of be-Neurotoxicity Syndromes', 'Fractures, Bone-be in-Diabetes Mellitus', 'Nerve Degeneration-potential mechanisms of be-Brain Ischemia', 'MIR31-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-MIR31', 'Osteogenesis Imperfecta-prevent-Bone Neoplasms', 'Osteogenesis Imperfecta-accelerate-Fractures, Bone', 'Bone Neoplasms-accelerate-Fractures, Bone', 'FNDC5-promote-Osteogenesis Imperfecta', 'Arteriolosclerosis-linked-MAPT', 'FGF23-analyzed-Chronic Kidney Disease-Mineral and Bone Disorder', 'FGF23-analyzed-Hemolytic-Uremic Syndrome', 'FNDC5-accelerate-Fractures, Bone', 'Chronic Kidney Disease-Mineral and Bone Disorder-emerging-Cardiovascular Diseases', 'Neoplasms-lead-Leukemia, Myeloid, Acute', 'TRAF6-repressed-Neoplasms', 'KL-emerging-Cardiovascular Diseases', 'TRAF6-lead-Leukemia, Myeloid, Acute', 'Cholesterol-be with-Death', 'Cholesterol-evaluate-Death', 'Cholesterol-evaluate-Parkinson Disease', 'Cardiomyopathy, Dilated-include-Heart Diseases', 'Cardiomyopathy, Dilated-include-HSPB8', 'Diabetes Mellitus-accelerate-Fasciculation', 'Diabetes Mellitus-accelerate-Inflammation', 'Diabetes Mellitus-accelerate-Mitochondrial Diseases', 'Diabetes Mellitus-accelerate-Obesity', 'Diabetes Mellitus-accelerate-INS', 'Mastocytosis, Systemic-be characteristic of-Parkinson Disease', 'Tauopathies-result-Neurodegenerative Diseases', 'Tauopathies-result-MAPT', 'MAPT-result-Neurodegenerative Diseases', 'Cholesterol-applied-Tauopathies', 'Neurodegenerative Diseases-defined-MAPT', 'EFEMP1-associated-Dementia', 'Dementia-associated-EFEMP1', 'EFEMP1-associated-Cerebrovascular Trauma', 'Cerebrovascular Trauma-associated-EFEMP1', 'EFEMP1-associated-Brain Infarction', 'Brain Infarction-associated-EFEMP1', 'EFEMP1-associated-Stroke', 'Stroke-associated-EFEMP1', 'Retinal Degeneration-prevent-Sarcopenia', 'Obesity-maintain-Glucose Metabolism Disorders', 'Obesity-contribute-INS', 'INS-maintain-Glucose Metabolism Disorders', 'FOXO3-associated-Neoplasms', 'Neoplasms-associated-FOXO3', 'FOXO3-associated-Death', 'Death-associated-FOXO3', 'RIOK2-correlate in-Myelodysplastic Syndromes', 'RIOK2-correlate-Leukemia, Myeloid, Acute', 'RIOK2-correlate-Renal Insufficiency, Chronic', 'PIN1-discussed-Inflammation', 'PIN1-serve-Aneurysm', 'PIN1-discussed-Diabetes Mellitus', 'PIN1-discussed-Atherosclerosis', 'PIN1-discussed-Hypertension', 'PIN1-discussed-Cardiomegaly', 'Neoplasms-of risks be-Cardiovascular Diseases', 'Denosumab-complicated-Fractures, Bone', 'Lipid Metabolism Disorders-decreased-Dyslipidemias', 'Lipid Metabolism Disorders-decreased-INS', 'Drug-Related Side Effects and Adverse Reactions-enhance-Infections', 'Drug-Related Side Effects and Adverse Reactions-enhance-HS3ST4', 'HS3ST4-enhance-Infections', 'SNCA-involved-Parkinson Disease', 'Neoplasms-include-Hematologic Diseases', 'Lewy Body Disease-compare-Alzheimer Disease', 'Lewy Body Disease-compare-TARDBP', 'Alzheimer Disease-composed-TARDBP', 'Dyspnea-increase-Glucose', 'Obesity, Abdominal-reduce-Cholesterol', 'Hyperglycemia-reduce-Cholesterol', 'Cholesterol-reduce-Hypertension', 'Glyceraldehyde-measure-Musculoskeletal Diseases', 'Pancreatic Diseases-mimic-Diabetes Mellitus, Type 2', 'GDA-be in-Keratosis, Seborrheic', 'Streptozocin-mimic-Diabetes Mellitus, Type 2', 'Colorectal Neoplasms-form-Neoplasms', 'Diabetes Mellitus-used-Prediabetic State', 'Diabetes Mellitus-used-Glomerulosclerosis, Focal Segmental', 'Glucose-used-Prediabetic State', 'Glucose-used-Glomerulosclerosis, Focal Segmental', 'SIRT6-observed-Angina, Stable', 'SIRT6-observed-Acute Coronary Syndrome', 'Edema-result-Rupture', 'Edema-trigger-Inflammation', 'Rupture-result-Inflammation', 'Lipofuscin-present-NLRP3', 'Parkinson Disease-increase-Infliximab', 'Edema-trigger-NLRP3', 'Rupture-result-NLRP3', 'Lipofuscin-cause-Edema', 'SIRT6-correlated-Coronary Artery Disease', 'Lipofuscin-result-Rupture', 'Lipofuscin-present-Inflammation', 'Metabolic Syndrome-overall prevalence of be-Diabetes Mellitus', 'Arthritis, Rheumatoid-described-Renal Insufficiency, Chronic', 'Renal Insufficiency, Chronic-moderated-Kidney Diseases', 'GLP1R-described-Renal Insufficiency, Chronic', 'Renal Insufficiency, Chronic-moderated-Arthritis, Rheumatoid', 'Kidney Diseases-moderated-Arthritis, Rheumatoid', 'Alzheimer Disease-tend-Neurotoxicity Syndromes', 'Fatty Acids, Unsaturated-tend-Alzheimer Disease', 'Fatty Acids, Unsaturated-depleted-Alzheimer Disease', 'CCK-transplanted-Diabetes Mellitus', 'Osteoarthritis-reduced-Joint Diseases', 'DOT1L-protect against-Osteoarthritis', 'DOT1L-reduced-Joint Diseases', 'Cyclosporine-restore-Dry Eye Syndromes', 'CISD2-disrupt-Infliximab', 'CISD2-disrupt-Corneal Diseases', 'Infliximab-disrupt-Corneal Diseases', 'FSTL3-associated-Death', 'Death-associated-FSTL3', 'Macular Degeneration-cause-Vision Disorders', 'Macular Degeneration-developed-VEGFA', 'VEGFA-cause-Vision Disorders', 'INHBE-experience-Respiration Disorders', 'Infections-include-MTOR', 'Inflammation-induced-Arbovirus Infections', 'MTOR-extend-Inflammation', 'MTOR-abrogate-Inflammation', 'MTOR-extend-Arbovirus Infections', 'MTOR-abrogate-Arbovirus Infections', 'Dyslipidemias-include-Aneurysm', 'Hyperglycemia-include-Aneurysm', 'Aneurysm-reduce-Inflammation', 'MIR34A-be in-Aneurysm', 'MIR34A-reduce-Inflammation', 'HDAC3-participate-Neoplasms', 'HDAC3-required-Cardiovascular Diseases', 'HDAC3-participate-Diabetes Mellitus', 'HDAC3-participate-Neurodegenerative Diseases', 'HDAC3-required-Kidney Diseases', 'Neoplasms-associated-KLK11', 'KLK11-associated-Neoplasms', 'Necrosis-associated-KLK11', 'KLK11-associated-Necrosis', 'Calcinosis-associated-KLK11', 'KLK11-associated-Calcinosis', 'DIAPH1-identified-Genetic Diseases, Inborn', 'DIAPH1-identified-Hearing Loss, Central', 'Bone Neoplasms-connected-SIRT1', 'Chemical and Drug Induced Liver Injury-reduce-Glucose Metabolism Disorders', 'Glucose-reduce-Chemical and Drug Induced Liver Injury', 'Cystic Fibrosis-need-Lung Diseases', 'Cystic Fibrosis-need-CFTR', 'Neoplasms-lead-STAT3', 'Latent Tuberculosis-associated-Parkinson Disease', 'Parkinson Disease-associated-Latent Tuberculosis', 'Latent Tuberculosis-associated-CD8A', 'CD8A-associated-Latent Tuberculosis', 'Hyperglycemia-define-Metabolic Syndrome', 'Triglycerides-define-Metabolic Syndrome', 'Retinal Neovascularization-accompanied-VEGFA', 'Endocrine System Diseases-determine-Hyperparathyroidism, Primary', 'Endocrine System Diseases-determine-Fatigue', 'Endocrine System Diseases-determine-Muscle Weakness', 'Endocrine System Diseases-characterized-PTH', 'Alzheimer Disease-phosphorylate-MAPT', 'Parkinson Disease-associated-Tremor', 'Tremor-associated-Parkinson Disease', 'MAPT-underlie-Memory Disorders', 'MAPT-underlie memory impairment in-Alzheimer Disease', 'HSPA5-increase-Obesity', 'HSPA5-increase-Diabetes Mellitus', 'rs17415557-associated-Alzheimer Disease', 'Alzheimer Disease-associated-rs17415557', 'Glucose-model of-Osteoarthritis', 'Glucose-be in-Breast Neoplasms, Male', 'Glucose-increase-Breast Neoplasms, Male', 'Diarrhea-enter-Ocular Motility Disorders', 'Castor Oil-enter-Ocular Motility Disorders', 'LEP-influenced-Weight Loss', 'Death-play-Inflammation', 'Death-show-Inflammation', 'CRP-play-Inflammation', 'Inflammation-expressed-CRP', 'MAPT-predict-Neurodegenerative Diseases', 'Insulin Resistance-affect-Neurodegenerative Diseases', 'INS-affect-Neurodegenerative Diseases', 'Leukemia, Myeloid, Acute-find-Neoplasms', 'Glucose-minimize-Alzheimer Disease', 'Diabetes Mellitus, Type 2-implicated-Alzheimer Disease', 'INS-implicated-Alzheimer Disease', 'Diabetes Mellitus-recognize-Alzheimer Disease', 'Diabetes Mellitus-characterized-INS', 'Death-control-Inflammation', 'Respiratory Insufficiency-control-Inflammation', 'Hypoxia-activate-PRKAB1', 'Alzheimer Disease-assess-Inflammation', 'Sleep Deprivation-activate-PRKAB1', 'FGF23-blocked-Alzheimer Disease', 'FGF23-assess-Inflammation', 'FGF23-regulate-Alzheimer Disease', 'FGF23-regulate-Inflammation', 'CD4-increase-Death, Sudden, Cardiac', 'HIV Infections-live-Death, Sudden, Cardiac', 'Sotos Syndrome-result-Immunologic Deficiency Syndromes', 'Sotos Syndrome-evolve-Neoplasms', 'Immunologic Deficiency Syndromes-evolve-Neoplasms', 'Immunologic Deficiency Syndromes-result from-Infections', 'Immunologic Deficiency Syndromes-target-CD4', 'GATA2-result-Immunologic Deficiency Syndromes', 'GATA2-evolve-Neoplasms', 'Infections-target-CD4', 'Osteosarcoma-include-Neoplasms', 'Osteosarcoma-linked-Neoplasms', 'Rothmund-Thomson Syndrome-linked-Neoplasms', 'Rothmund-Thomson Syndrome-mutated-RECQL4', 'RECQL4-result-Rothmund-Thomson Syndrome', 'RECQL4-deserve-Rothmund-Thomson Syndrome', 'Mitochondrial Diseases-cause-Nerve Degeneration', 'INS-develop-Metabolic Diseases', 'INS-develop-Neoplasms', 'SARM1-cause-Mitochondrial Diseases', 'SARM1-cause-Nerve Degeneration', 'MAPT-underlie-Nervous System Diseases', 'Lymphopenia-levels of-CRP', 'GSDME-suppressed-Neoplasms', 'WRN-explain-Werner Syndrome', 'WRN-explain-Metabolic Diseases', 'Metabolic Syndrome-associate-ALB', 'ALB-associate-Metabolic Syndrome', 'ALB-linked-Death', 'Insulin Resistance-include-INS', 'Obesity-include-INS', 'Heparin, Low-Molecular-Weight-associated-Venous Thrombosis', 'Venous Thrombosis-associated-Heparin, Low-Molecular-Weight', 'Heparin, Low-Molecular-Weight-associated-Pulmonary Embolism', 'Pulmonary Embolism-associated-Heparin, Low-Molecular-Weight', 'KL-associated-Osteoporosis', 'Osteoporosis-associated-KL', 'KL-associated-Death', 'Death-associated-KL', 'Death-induce-Thrombosis', 'Diabetes Mellitus-caused-Hypoglycemia', 'Diabetes Mellitus-administer-INS', 'Hypoglycemia-caused-INS', 'Hypoglycemia-administer-INS', 'HHLA2-associated-Neoplasms', 'Neoplasms-associated-HHLA2', 'HHLA2-associated-Stomach Neoplasms', 'Stomach Neoplasms-associated-HHLA2', 'HHLA2-associated-Cholangiocarcinoma', 'Cholangiocarcinoma-associated-HHLA2', 'HHLA2-associated-Lung Neoplasms', 'Lung Neoplasms-associated-HHLA2', 'HHLA2-associated-Carcinoma, Ovarian Epithelial', 'Carcinoma, Ovarian Epithelial-associated-HHLA2', 'Brain Neoplasms-implicated-Neoplasms', 'Inflammation-include-Muscular Atrophy', 'MTOR-include-Muscular Atrophy', 'Fluvastatin-indicated-Hypercholesterolemia', 'Fluvastatin-administered-Fatigue', 'Fluvastatin-admitted-Fatigue', 'Fluvastatin-administered-Muscle Weakness', 'Fluvastatin-admitted-Muscle Weakness', 'Lung Diseases-demonstrate-Infections', 'Fluvastatin-admitted-Abdominal Pain', 'Fluvastatin-admitted-Vomiting', 'IFIH1-demonstrate-Infections', 'Fluvastatin-admitted-Pruritus', 'Lymphopenia-be contribute factors in-Infections', 'Lymphopenia-be contribute factors in-Myositis', 'Infections-be in-Myositis', 'Myocardial Infarction-upregulate-NPPA', 'IFIH1-be contribute factors in-Infections', 'IFIH1-be contribute factors in-Myositis', 'Death-upregulate-NPPA', 'Chemical and Drug Induced Liver Injury-manage-Hyperinsulinism', 'INS-manage-Hyperinsulinism', 'Thioctic Acid-open-Infections', 'NOTCH3-include-Leukoencephalopathies', 'NOTCH3-selected-Leukoencephalopathies', 'rs201118034-selected-Leukoencephalopathies', 'rs1801133-associated-Hypertension', 'Hypertension-associated-rs1801133', 'Cerebrovascular Disorders-noted-Pneumonia, Aspiration', 'Dementia-noted-Pneumonia, Aspiration', 'Neuromuscular Diseases-noted-Pneumonia, Aspiration', 'CRP-noted-Pneumonia, Aspiration', 'H19-associated-Epilepsy', 'Epilepsy-associated-H19', "Sjogren's Syndrome-proposed-Xerostomia", 'PLIN2-decorated-Inflammation', 'PLIN2-decorated-Neurodegenerative Diseases', 'Hypoglycemia-associated-Fractures, Bone', 'Fractures, Bone-associated-Hypoglycemia', 'Glucose-considered-Hypoglycemia', 'Glucose-considered-Fractures, Bone', 'Glucose-considered-Death', 'Diabetes Mellitus-impact-Neurodegenerative Diseases', 'Diabetes Mellitus-impact-Alzheimer Disease', 'Diabetes Mellitus-impact-MAPT', 'Alzheimer Disease-include-Tauopathies', 'HMGB1-represent-Tauopathies', 'HMGB1-represent-Alzheimer Disease', 'Infections-lowering-Diabetes Mellitus', 'Infections-lowering-Hypertension', 'Infections-lowering-Obesity', 'SLC9C1-cause-Infections', 'SLC9C1-lowering-Diabetes Mellitus', 'SLC9C1-lowering-Hypertension', 'SLC9C1-lowering-Obesity', 'Neoplasms-associated-Lipoma', 'Lipoma-associated-Neoplasms', 'PTEN-cause-Neoplasms', 'APOE-associated-Hyperlipidemias', 'Hyperlipidemias-associated-APOE', 'PTEN-cause-Lipoma', 'PTEN-associated-Lipoma', 'Lipoma-associated-PTEN', 'APOE-associated-Obesity', 'Obesity-associated-APOE', 'Neurodegenerative Diseases-associated-Delirium', 'Delirium-associated-Neurodegenerative Diseases', 'MAPT-associated-Delirium', 'Delirium-associated-MAPT', 'Osteoarthritis-elevated expression of-Cartilage Diseases', 'Osteoarthritis-mimic-Cartilage Diseases', 'GNRHR-involved-Hyperinsulinism', 'GNRHR-involved-Diabetes Mellitus', 'GNRHR-involved-Arthritis', 'GNRHR-involved-Cerebrovascular Disorders', 'GNRHR-involved-Neoplasms', 'Drug-Related Side Effects and Adverse Reactions-observed-Breast Neoplasms', 'Drug-Related Side Effects and Adverse Reactions-observed-Trastuzumab', 'SIRT3-be novel therapeutic focus for-Idiopathic Pulmonary Fibrosis', 'SIRT3-manage-Idiopathic Pulmonary Fibrosis', 'Bleomycin-augmented-SIRT3', 'Fibrosis-augmented-SIRT3', 'Fibrosis-trigger-Denys-Drash Syndrome', 'Fibrosis-boost-FGF23', 'FGF23-trigger-Denys-Drash Syndrome', 'Myeloproliferative Disorders-associated-TET2', 'TET2-associated-Myeloproliferative Disorders', 'Obesity-differ-Hypertension', 'Obesity-differ-Hyperglycemia', 'Obesity-differ-Triglycerides', 'Neurodegenerative Diseases-lead to-Alzheimer Disease', 'Neurodegenerative Diseases-represent-GRIN3A', 'GRIN3A-develop-Olfaction Disorders', 'Alzheimer Disease-represent-GRIN3A', 'GRIN3A-display-Infliximab', 'GRIN3A-display-Hyperkinesis', 'GRIN3A-display-Nerve Degeneration', 'NFKB1-hyperactivated-Myeloproliferative Disorders', 'NFKB1-remodel-Neoplasms', 'Pulmonary Disease, Chronic Obstructive-reflect-Lysosomal Storage Diseases, Nervous System', 'Lipofuscin-reflect-TRIM16', 'Pulmonary Disease, Chronic Obstructive-reflect-TRIM16', 'Lysosomal Storage Diseases, Nervous System-be with-TRIM16', 'Lipofuscin-reflect-Lysosomal Storage Diseases, Nervous System', 'Alzheimer Disease-given-Neurodegenerative Diseases', 'Sepsis-discuss-Neurologic Manifestations', 'Alzheimer Disease-linked-Nerve Degeneration', 'Sepsis-discuss-PARP1', 'Neurodegenerative Diseases-linked-Nerve Degeneration', 'Alzheimer Disease-hypothesized-Neurodegenerative Diseases', 'Alzheimer Disease-drive-Neurodegenerative Diseases', 'Alzheimer Disease-reflect-Neurodegenerative Diseases', 'MAPT-drive-Neurodegenerative Diseases', 'Alzheimer Disease-hypothesized-MAPT', 'MAPT-linked-Nerve Degeneration', 'Necrosis-use-Bone Neoplasms', 'Atrioventricular Block-associated-Hypertension', 'Hypertension-associated-Atrioventricular Block', 'Calcifediol-use-Necrosis', 'Atrioventricular Block-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-Atrioventricular Block', 'Atrioventricular Block-associated-Cholesterol', 'Cholesterol-associated-Atrioventricular Block', 'CLCA1-associated-Immunologic Deficiency Syndromes', 'Immunologic Deficiency Syndromes-associated-CLCA1', 'CLCA1-lead to-Wounds and Injuries', 'CLCA1-associated-Wounds and Injuries', 'Wounds and Injuries-associated-CLCA1', 'Metabolic Diseases-protect-Neurologic Manifestations', 'Multiple Organ Failure-protect-Neurologic Manifestations', 'Sepsis-protect-Neurologic Manifestations', 'PARP1-protect-Neurologic Manifestations', 'PARP1-protect-Metabolic Diseases', 'PARP1-protect-Multiple Organ Failure', 'PARP1-protect-Sepsis', 'Alzheimer Disease-get-ACE2', 'Metabolic Syndrome-represent-Metabolic Diseases', 'Intestinal Diseases-be in-HIV Infections', 'Metabolic Diseases-arise-Lipoma', 'Metabolic Diseases-arise-INS', 'Dyslipidemias-linked-Hypertension', 'SHBG-associated-Dyslipidemias', 'Dyslipidemias-associated-SHBG', 'SHBG-associated-Hypertension', 'Hypertension-associated-SHBG', 'SHBG-linked-Hypertension', 'Glucose Intolerance-associated-Inflammation', 'Inflammation-associated-Glucose Intolerance', 'Diabetes Mellitus-associated-Inflammation', 'Inflammation-associated-Diabetes Mellitus', 'Sarcopenia-evaluated-ALB', 'Death-attenuate-Cardiovascular Diseases', 'PIK3R1-attenuate-Death', 'PIK3R1-attenuate mortality risk by-Cardiovascular Diseases', 'Hyperglycemia-induced-INS', 'Death-estimate-CD4', 'INS-induced-Heart Diseases', 'INS-induced-Heart Failure', 'INS-related-Diabetes Mellitus', 'INS-act-Chemical and Drug Induced Liver Injury', 'INS-regulate-Hypoglycemia', 'Arbovirus Infections-treat-Immunologic Deficiency Syndromes', 'SIRT1-treat-Arbovirus Infections', 'SIRT1-treat-Immunologic Deficiency Syndromes', 'Cholesterol-associated-Leukoencephalopathies', 'Leukoencephalopathies-associated-Cholesterol', 'Cardiovascular Diseases-affect-Heart Failure', 'SIRT2-affect-Cardiovascular Diseases', 'SIRT2-affect-Heart Failure', 'Inflammation-be classic characteristic of-Sepsis', 'Inflammation-suppression of-HMGB1', 'Inflammation-ameliorate-HMGB1', 'Heart Failure-involve-Heart Diseases', 'Heart Diseases-elucidate-Heart Failure', 'Heart Diseases-involve-TTR', 'Heart Failure-involve-TTR', 'Heart Diseases-deposition of-TTR', 'TTR-involve-Heart Diseases', 'TTR-elucidate-Heart Diseases', 'Inflammation-considered-Diabetic Nephropathies', 'AGER-target-Inflammation', 'AGER-considered-Inflammation', 'AGER-considered-Diabetic Nephropathies', 'Inflammation-be major deleterious effect of-Diabetes Mellitus', 'GLS-identified-Neoplasms', 'GLS-target-Neoplasms', 'Cardiovascular Diseases-identified-GLS', 'Atrial Fibrillation-play-Mitochondrial Diseases', 'Bone Neoplasms-inhibit-Inflammation', 'Fish Oils-prevent-Bone Neoplasms', 'Fish Oils-prevent-Inflammation', 'Fish Oils-inhibit-Inflammation', 'Cholesterol-compare-Coronary Artery Disease', 'Cholesterol-compare-Cardiovascular Diseases', 'Osteoporotic Fractures-demonstrated-Teriparatide', 'Inflammation-protect In-Asthma', 'Asthma-protect-Infections', 'Inflammation-protect against-Infections', 'Asthma-produce-ACE2', 'ADNP-drive-Alzheimer Disease', 'Alzheimer Disease-drive-ADNP', 'ADNP-drive-Tauopathies', 'Inflammation-produce-ACE2', 'Infections-produce-ACE2', 'Immunologic Deficiency Syndromes-linked-Metabolic Syndrome', 'TP53INP1-linked-Immunologic Deficiency Syndromes', 'TP53INP1-linked-Neoplasms', 'TP53INP1-linked-Metabolic Syndrome', 'MAPT-support-Dementia', 'Alzheimer Disease-understand-Neurodegenerative Diseases', 'Supranuclear Palsy, Progressive-contribute-Neurodegenerative Diseases', 'Immunologic Deficiency Syndromes-observed-Osteoarthritis', 'Immunologic Deficiency Syndromes-increase-MTOR', 'Frontotemporal Lobar Degeneration-contribute-Neurodegenerative Diseases', 'Tauopathies-contribute-Neurodegenerative Diseases', 'Supranuclear Palsy, Progressive-be neuropathologic subtypes with-MAPT', 'Metabolic Syndrome-use-Diabetes Mellitus', 'MAPT-contribute to-Neurodegenerative Diseases', 'Metabolic Syndrome-use-Glucose', 'Rhinitis, Allergic-induce-ACE', 'Asthma-induce-ACE', 'GPNMB-increased-Alzheimer Disease', 'Osteoporosis-be in-Diabetes Mellitus', 'GPNMB-associated-Parkinson Disease', 'Parkinson Disease-associated-GPNMB', 'PIWIL1-expressed-Neurodegenerative Diseases', 'Cardiovascular Diseases-base-Diabetes Mellitus', 'Cardiovascular Diseases-base-Cholesterol', 'Inflammation-play role in-INS', 'Glucose Metabolism Disorders-compare-Glucose', 'Neurotoxicity Syndromes-drive-Neurodegenerative Diseases', 'Infliximab-shown-Neurotoxicity Syndromes', 'Osteoporosis-gain-Femoral Fractures', 'Denosumab-used-Osteoporosis', 'Denosumab-gain-Femoral Fractures', 'Genetic Diseases, Inborn-caused-WRN', 'Fibrosis-undergo-Hemangioma', 'CHI3L1-be higher in-Fibrosis', 'CHI3L1-undergo-Hemangioma', 'Alzheimer Disease-protect-Nerve Degeneration', 'Congenital Hyperinsulinism-phosphorylation of-AKT1', 'Alzheimer Disease-inhibit-Neurotoxicity Syndromes', 'Nerve Degeneration-inhibit-Neurotoxicity Syndromes', 'Alzheimer Disease-suppress-ACHE', 'Nerve Degeneration-suppress-ACHE', 'CRP-reduce-Inflammation', 'Metabolic Syndrome-develop-Glucose Intolerance', 'AHR-be higher in-Metabolic Syndrome', 'AHR-develop-Glucose Intolerance', 'Alzheimer Disease-investigate-Sucrose', 'KL-consider-Acute Kidney Injury', 'KL-consider-Cardio-Renal Syndrome', 'KL-consider-Diabetes Mellitus', 'Dyslipidemias-defined-Cardiovascular Diseases', 'Cholesterol-be higher base-Cardiovascular Diseases', 'INS-associated-Cerebrovascular Disorders', 'Cerebrovascular Disorders-associated-INS', 'INS-associated-Infarction', 'Infarction-associated-INS', 'HIV Infections-associated-Obesity', 'Obesity-associated-HIV Infections', 'Infections-directed-Neoplasms', 'CD4-associated-Obesity', 'Obesity-associated-CD4', 'Brain Injuries, Traumatic-acetylated-Alzheimer Disease', 'Brain Injuries, Traumatic-induce-MAPT', 'TNNT1-associated-Multiple Organ Failure', 'Multiple Organ Failure-associated-TNNT1', 'MAPT-acetylated-Alzheimer Disease', 'Infections-directed-FURIN', 'Neoplasms-directed-FURIN', 'Alzheimer Disease-be with-Brain Injuries, Traumatic', 'Alzheimer Disease-augmented-Brain Injuries, Traumatic', 'CREBBP-diagnose-Brain Injuries, Traumatic', 'Metabolic Syndrome-contribute-Memory Disorders', 'Cholesterol-contribute-Memory Disorders', 'GPR35-suppressed-Osteoporosis', 'GPR35-suppressed-Osteoporotic Fractures', 'VEGFA-up-regulated-Uremia', 'VEGFA-up-regulated-Inflammation', 'Heart Arrest-preexist-Diabetes Mellitus', 'ADIPOQ-involved-Chronic Disease', 'ADIPOQ-promote-Chronic Disease', 'ADIPOQ-involved-Alzheimer Disease', 'Angioedemas, Hereditary-considered-Angioedema', 'KNG1-treat-Angioedemas, Hereditary', 'KNG1-considered-Angioedema', 'INHBE-promote-Inflammation', 'INHBE-promote-Neoplasms', 'Hyperoxia-reduced-Hypoxia', 'SIRT1-induced-Hyperoxia', 'SIRT1-reduced-Hypoxia', 'Mitochondrial Diseases-result-INS', 'Glutathione-result-Mitochondrial Diseases', 'HPSE-demonstrated-Neoplasms', 'HPSE-suggest-Thrombosis', 'Heparitin Sulfate-demonstrated-Neoplasms', 'Heparitin Sulfate-suggest-Thrombosis', 'Inflammation-link-Metabolic Diseases', 'ADIPOQ-link-Metabolic Diseases', 'TWIST1-contribute-Pulmonary Fibrosis', 'TWIST1-contribute-Atherosclerosis', 'Glioma, Subependymal-include-MAPT', 'Osteoarthritis-found-Hypertension', 'Osteoarthritis-found-Diabetes Mellitus', 'Osteoarthritis-found-Asthma', 'Osteoarthritis-found-Dyslipidemias', 'Atrial Fibrillation-depend-Fibrosis', 'Osteoarthritis-found-PTH', 'C9orf72-cause-Dementia', 'Osteoarthritis-found-Cholesterol', 'MAP3K5-caused-Communicable Diseases', 'Hyperkinesis-prevent-Alzheimer Disease', 'Alzheimer Disease-affect-Infections', 'EDN1-increased-Alzheimer Disease', 'EDN1-affect-Infections', 'Osteosarcoma-promote-Neoplasms', 'FOXP1-be in-Osteosarcoma', 'FOXP1-promote-Neoplasms', 'Neoplasms-correlate-Osteosarcoma', 'Retinoblastoma-interact-Neoplasms', 'FOXP1-correlate with-Neoplasms', 'FOXP1-interact-Retinoblastoma', 'FOXP1-correlate in-Osteosarcoma', 'FOXP1-interact-Neoplasms', 'Inflammation-support-Genetic Diseases, Inborn', 'INS-support-Inflammation', 'INS-associated-Genetic Diseases, Inborn', 'Genetic Diseases, Inborn-associated-INS', 'Pain-relieve-Osteoarthritis', 'Oils-relieve-Pain', 'Oils-relieve-Osteoarthritis', 'Craniocerebral Trauma-damaging-Alzheimer Disease', 'Craniocerebral Trauma-damaging-Neurodegenerative Diseases', 'Craniocerebral Trauma-damaging-NEFL', 'Unconsciousness-associated-NEFL', 'NEFL-associated-Unconsciousness', 'Craniocerebral Trauma-associated-NEFL', 'NEFL-associated-Craniocerebral Trauma', 'ALB-history of-Delirium', 'Cardiovascular Diseases-include-Metabolic Diseases', 'INS-underpin-Metabolic Diseases', 'INS-underpin-Diabetes Mellitus, Type 2', 'INS-underpin-Metabolic Syndrome', 'INS-underpin-Cardiovascular Diseases', 'IGF2-treat-Alzheimer Disease', 'IGF2-treat-Huntington Disease', 'Drug-Related Side Effects and Adverse Reactions-investigate-Death', 'Ouabain-investigate-Death', 'BDNF-associated-Alzheimer Disease', 'Alzheimer Disease-associated-BDNF', 'Infliximab-changed-Diabetes Mellitus', 'Infliximab-changed-Ischemia', 'Deafness-define-Mastocytosis, Systemic', 'Lipodystrophy-define-Mastocytosis, Systemic', 'Deafness-define-POLD1', 'Lipodystrophy-define-POLD1', 'Metabolic Diseases-elevate-INS', 'MIF-mediate-Arthritis, Rheumatoid', 'Inflammation-develop-Atrial Fibrillation', 'CRP-develop-Atrial Fibrillation', 'RUNX3-implicated-Neoplasms', 'Coronary Artery Disease-prevent-Atherosclerosis', 'Breast Neoplasms-characterized-PTX3', 'ACE2-increase in-Lung Injury', 'ACE2-provide-Death', 'PTPN11-play roles in-Neoplasms', 'PTPN11-play roles in-Inflammation', 'PTPN11-play-Neurodegenerative Diseases', 'PTPN11-play-Metabolic Diseases', 'Glucose-assessed-Prediabetic State', 'Glucose-assessed-Glucose Intolerance', 'Glucose-assessed-Diabetes Mellitus', 'Inflammation-induce-Bone Neoplasms', 'Inflammation-protect-Bone Neoplasms', 'Anthocyanins-protect-Inflammation', 'Erectile Dysfunction-correlated-Cholesterol', 'Anthocyanins-protect-Bone Neoplasms', 'Lysosomal Storage Diseases-characterized-Glycosphingolipids', 'Cholesterol-contribute-Cardiovascular Diseases', 'Cholesterol-contribute-Death', 'SQSTM1-associated-Amyotrophic Lateral Sclerosis', 'Amyotrophic Lateral Sclerosis-associated-SQSTM1', 'SQSTM1-associated-Dementia', 'Dementia-associated-SQSTM1', 'Neoplasms-associated-Headache', 'Headache-associated-Neoplasms', 'Fever-associated-Headache', 'Headache-associated-Fever', 'Dehydration-associated-Headache', 'Headache-associated-Dehydration', 'CRP-associated-Headache', 'Headache-associated-CRP', 'Glucose Intolerance-develop-Diabetes Mellitus', 'Glucose Intolerance-develop-INS', 'Hypotension-considered-Diabetes Mellitus', 'INS-show-Alzheimer Disease', 'Cholesterol-considered-Diabetes Mellitus', 'KL-associated-Neurodegenerative Diseases', 'Neurodegenerative Diseases-associated-KL', 'Diabetes Mellitus-history of-Stroke', 'ACE2-altered-Hypertension', 'ACE2-altered-Diabetes Mellitus', 'Friedreich Ataxia-derived-Primary Dysautonomias', 'Glutathione-correct-ELP1', 'ELP1-derived-Primary Dysautonomias', 'Friedreich Ataxia-protect-Glutathione', 'Glutathione-protect-Primary Dysautonomias', 'Bacterial Infections-mediate-Infections', 'PPIA-involved-Bacterial Infections', 'PPIA-mediate-Infections', 'PPIA-play role Besides-Cyclosporine', 'PPIA-play role in-Infections', 'PPIA-play-Cardiovascular Diseases', 'PPIA-play-Liver Diseases', 'ACE2-circulate-Inflammation', 'ACE2-illustrate-Inflammation', 'PPIA-play-Kidney Diseases', 'PPIA-play-Neurodegenerative Diseases', 'ACE2-circulate-Cardiovascular Diseases', 'ACE2-illustrate-Cardiovascular Diseases', 'PPIA-play-Neoplasms', 'PPIA-play-Arthritis, Rheumatoid', 'PPIA-play-Periodontitis', 'PPIA-play-Sepsis', 'PPIA-play-Asthma', 'NEFL-recognized-Basal Ganglia Diseases', 'NEFL-recognized-Alzheimer Disease', 'Cyclosporine-play-Infections', 'Cyclosporine-play-Cardiovascular Diseases', 'Inflammation-prevent-Fibrosis', 'Cyclosporine-play-Liver Diseases', 'Cyclosporine-play-Kidney Diseases', 'Cyclosporine-play-Neurodegenerative Diseases', 'Cyclosporine-play-Neoplasms', 'Cyclosporine-play-Arthritis, Rheumatoid', 'Cyclosporine-play-Periodontitis', 'Cyclosporine-play-Sepsis', 'Cyclosporine-play-Asthma', 'ACE2-be elevated in-Peripheral Arterial Disease', 'Fractures, Bone-indicate-Osteoporosis', 'Osteomalacia-indicate-Osteoporosis', 'ALPP-indicate-Osteoporosis', 'ACE2-implicated-Cardiovascular Diseases', 'ALPP-raised-Heart Failure', 'ALPP-raised-Renal Insufficiency, Chronic', 'Cerebral Amyloid Angiopathy-differentiate-Alzheimer Disease', 'rs1990622-expression of-TMEM106B', 'rs1990622-regulate-TMEM106B', 'rs1990622-show-TMEM106B', 'Fluorodeoxyglucose F18-differentiate-Cerebral Amyloid Angiopathy', 'Fluorodeoxyglucose F18-differentiate-Alzheimer Disease', 'rs1990622-contribute to-Alzheimer Disease', 'Alzheimer Disease-accompanied-Learning Disabilities', 'DMD-include-Fibrosis', 'Alzheimer Disease-accompanied-MAPT', 'ACE2-explain-Asthma', 'ACE2-be lower in-Asthma', 'ELN-involve-Calcinosis', 'Fatigue-involve-ELN', 'Fatty Acids-observed-Metabolic Diseases', 'Myotonic Dystrophy-defined-Glucose', 'KL-decrease-Renal Insufficiency, Chronic', 'Hyperinsulinism-described-Adrenal Hyperplasia, Congenital', 'Hyperinsulinism-described-Diabetes Mellitus', 'INS-described-Adrenal Hyperplasia, Congenital', 'INS-described-Diabetes Mellitus', 'Alzheimer Disease-advanced-HDAC1', 'Amyotrophic Lateral Sclerosis-advanced-HDAC1', 'HDAC1-identified-Alzheimer Disease', 'Mitochondrial Diseases-lead-Alzheimer Disease', 'Alzheimer Disease-activate-HDAC1', 'Inflammation-lead-Alzheimer Disease', 'Parkinson Disease-activate-HDAC1', 'MAPT-lead-Alzheimer Disease', 'Lupus Erythematosus, Systemic-include-Autoimmune Diseases', 'Inflammatory Bowel Diseases-include-Autoimmune Diseases', 'Spondylitis, Ankylosing-include-Autoimmune Diseases', 'Myositis-include-Autoimmune Diseases', 'Multiple Sclerosis-include-Autoimmune Diseases', 'Scleroderma, Systemic-include-Autoimmune Diseases', 'Huntington Disease-include-Neurodegenerative Diseases', 'Alzheimer Disease-produce-MAPT', 'Tauopathies-produce-MAPT', 'WFDC2-predict-Pulmonary Disease, Chronic Obstructive', 'Cholesterol-linked-Neurodegenerative Diseases', 'Cholesterol-linked-Alzheimer Disease', 'Cholesterol-linked-Parkinson Disease', 'WFDC2-enable-Pulmonary Disease, Chronic Obstructive', 'Inflammation-be major pathological hallmark of-Neurodegenerative Diseases', 'Cholesterol-linked-Huntington Disease', 'Phytosterols-implicate-Multiple Sclerosis', 'APOE-take-Death', 'TMEM106B-associated-Pelizaeus-Merzbacher Disease', 'Pelizaeus-Merzbacher Disease-associated-TMEM106B', 'TMEM106B-associated-Neurodegenerative Diseases', 'Neurodegenerative Diseases-associated-TMEM106B', 'TMEM106B-associated-Brain Diseases', 'Brain Diseases-associated-TMEM106B', 'Tramadol-be prescribe analgesic drug for-Pain', 'Tramadol-lead-Pneumonia', 'Leukemia, Myelomonocytic, Chronic-include-Myelodysplastic Syndromes', 'Delirium-apply-Inflammation', 'Inflammation-induced-Delirium', 'Delirium-apply-Lipopolysaccharides', 'Delirium-induced-Lipopolysaccharides', 'Inflammation-induced-Lipopolysaccharides', 'Lipopolysaccharides-induced-Delirium', 'Anemia-generated-Neoplasms', 'Streptozocin-lead-Albuminuria', 'Streptozocin-lead-Kidney Diseases', 'Thrombosis-interact-Cardiovascular Diseases', 'Thrombosis-interact-Sepsis', 'Inflammation-interact-Cardiovascular Diseases', 'MIR146A-implicated-Thrombosis', 'MIR146A-implicated-Inflammation', 'MIR146A-implicated-Cardiovascular Diseases', 'MIR146A-implicated-Sepsis', 'PWRN2-alleviate-Death', 'PWRN2-alleviate-Mitochondrial Diseases', 'Obesity-accelerate-INS', 'Obesity-coexist-Hypertension', 'RBFOX1-implicated-Nervous System Diseases', 'INS-coexist-Hypertension', 'Brain Injuries-result-Fatty Acids, Omega-3', 'Neurodegenerative Diseases-result-Fatty Acids, Omega-3', 'Alzheimer Disease-result-Fatty Acids, Omega-3', 'Chronic Traumatic Encephalopathy-result-Fatty Acids, Omega-3', 'Vascular Calcification-investigated-Coronary Artery Disease', 'KL-investigated-Coronary Artery Disease', 'SIRT6-summarize-Neoplasms', 'SIRT6-summarize-Inflammation', 'SIRT6-summarize-Diabetes Mellitus', 'SIRT6-summarize-Fatty Liver', 'SIRT6-summarize-Arthritis', 'SIRT6-summarize-Cardiovascular Diseases', 'SIRT6-summarize-Neurodegenerative Diseases', 'SIRT6-summarize-Arbovirus Infections', 'SIRT6-summarize-Corneal Diseases', 'Parkinson Disease-include-Mitochondrial Diseases', 'Phosphatidylcholines-be lower in-Alzheimer Disease', 'Phosphatidylcholines-be lower with-Hearing Loss', 'FOXO3-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-FOXO3', 'FOXO3-test-Death', 'FOXO3-associated-Hypertension', 'Hypertension-associated-FOXO3', 'FOXO3-test-Communicable Diseases', 'TTR-abolished-Hypotension', 'TTR-abolished-Drug-Related Side Effects and Adverse Reactions', 'Coronary Artery Disease-be in-Diabetes Mellitus', 'Coronary Artery Disease-associated-SIRT1', 'SIRT1-associated-Coronary Artery Disease', 'Diabetes Mellitus-associated-SIRT1', 'SIRT1-associated-Diabetes Mellitus', 'INS-be cornerstone in-Diabetes Mellitus', 'INS-be cornerstone of-Diabetes Mellitus', 'INS-be cornerstone in-Diabetes Mellitus, Type 2', 'Hypoglycemia-find-Diabetes Mellitus', 'Insulin Glargine-emerge-Hypoglycemia', 'Insulin Glargine-emerge-Diabetes Mellitus', 'Non-alcoholic Fatty Liver Disease-defined-Fatty Liver', 'Glucose-defined-Fatty Liver', 'Triglycerides-defined-Non-alcoholic Fatty Liver Disease', 'Glycerol-associated-Constipation', 'Constipation-associated-Glycerol', 'Glycerol-associated-Leukocytosis', 'Leukocytosis-associated-Glycerol', 'HIV Infections-defined-Acquired Immunodeficiency Syndrome', 'HIV Infections-defined-CD4', 'Heart Failure-be with-Diabetes Mellitus', 'Heart Failure-treat-Diabetes Mellitus', 'Nerve Degeneration-increase-Alzheimer Disease', 'NEFL-increase-Nerve Degeneration', 'NEFL-be related to-Neurodegenerative Diseases', 'NEFL-increase-Neurodegenerative Diseases', 'Alzheimer Disease-considered-Glucose Metabolism Disorders', 'CRP-noted-Venous Thromboembolism', 'Osteoarthritis-degrade-CASZ1', 'Inflammation-degrade-CASZ1', 'CASZ1-prevent-Inflammation', 'CASZ1-prevent-Osteoarthritis', 'Neurodegenerative Diseases-play-ACE2', 'Inflammation-modulate-Infections', 'Ascorbic Acid-modulate-Inflammation', 'Ascorbic Acid-modulate-Infections', 'Respiratory Tract Diseases-clarify-Infections', 'Ascorbic Acid-clarify-Infections', 'Hip Fractures-related-Osteoporosis', 'C9orf72-cause-Amyotrophic Lateral Sclerosis', 'Infections-suggest-Respiratory Tract Diseases', 'Osteogenesis Imperfecta-reduce-Bone Neoplasms', 'Fatty Acids-polyunsaturated-Inflammation', 'Fatty Acids-polyunsaturated-Osteogenesis Imperfecta', 'EREG-emerging-Glucose', 'EREG-contribute-Alzheimer Disease', 'EREG-emerging-Brain Diseases, Metabolic', 'Pneumonia-presented-CRP', 'CENPF-inhibit-Pancreatic Neoplasms', 'CENPF-cause-Heart Arrest', 'Insulin Detemir-reduce-Myoclonus', 'MAPT-drive-Hyperkinesis', 'MAPT-related-Alzheimer Disease', 'INS-reduce-Myoclonus', 'Insulin Glargine-reduce-Myoclonus', 'Chronic Disease-contribute-Diabetes Mellitus', 'Obesity-shown-Diabetes Mellitus', 'Obesity-contribute-Diabetes Mellitus', 'INS-shown-Diabetes Mellitus', 'AIDS Arteritis, Central Nervous System-encompass-AQP4', 'Alzheimer Disease-contribute-HIV Infections', 'Alzheimer Disease-define-Brain Diseases', 'AIDS Arteritis, Central Nervous System-suffer-AQP4', 'HIV Infections-Similar contribute with-AQP4', 'Brain Diseases-define-Sclerosis', 'Aging, Premature-encode-LMNA', 'MTNR1B-associated-Glucose', 'Glucose-associated-MTNR1B', 'MTNR1B-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-MTNR1B', 'MTNR1B-focus-Diabetes Mellitus', 'MTNR1B-associated-Diabetes Mellitus, Type 2', 'Diabetes Mellitus, Type 2-associated-MTNR1B', 'MTNR1B-focus-Diabetes Mellitus, Type 2', 'rs10830963-associated-Glucose', 'Glucose-associated-rs10830963', 'rs10830963-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-rs10830963', 'rs10830963-associated-Diabetes Mellitus, Type 2', 'Diabetes Mellitus, Type 2-associated-rs10830963', 'Muscular Dystrophy, Duchenne-caused-Muscular Atrophy', 'Muscular Dystrophy, Duchenne-caused-Respiratory Insufficiency', 'Muscular Atrophy-caused-Respiratory Insufficiency', 'Renal Insufficiency, Chronic-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-Renal Insufficiency, Chronic', 'Metabolic Diseases-underlie-Renal Insufficiency, Chronic', 'DMD-result-Muscular Atrophy', 'Renal Insufficiency, Chronic-associated-INS', 'INS-associated-Renal Insufficiency, Chronic', 'DMD-result-Respiratory Insufficiency', 'DMD-caused-Respiratory Insufficiency', 'PRKAB1-associated-Metabolic Diseases', 'Metabolic Diseases-associated-PRKAB1', 'PRKAB1-underlie-Renal Insufficiency, Chronic', 'Kidney Diseases-demonstrate-PRKAB1', 'Fanconi Anemia-be in-Neoplasms', 'Metabolic Syndrome-characterized-Obesity', 'Metabolic Syndrome-characterized-Dyslipidemias', 'Metabolic Syndrome-characterized-INS', 'TG-be elevated in-Thyroid Diseases', 'TG-be elevated in-Hyperthyroidism', 'TG-be elevated in-Goiter', 'Metabolic Syndrome-increasing-INS', 'Sarcopenia-current knowledge regard-Heart Failure', 'Sarcopenia-be in-Heart Failure', 'Obesity-increasing-INS', 'Inflammation-include-Heart Failure', 'MSTN-include-Heart Failure', 'Sugars-accumulate-Diabetes Mellitus', 'Lipodystrophy-associated-LMNA', 'LMNA-associated-Lipodystrophy', 'FNDC5-ameliorate-Osteoporosis', 'FNDC5-ameliorate-Muscular Atrophy', 'AMH-compare-Diabetes Mellitus, Type 2', 'AMH-develop-Diabetes Mellitus, Type 2', 'Neurodegenerative Diseases-characterized-MAPT', 'AMH-compare-Diabetes Mellitus', 'AMH-develop-Diabetes Mellitus', 'Dementia-seen-APOE', 'Osteoporosis-experience-Denosumab', 'Fractures, Stress-experience-Denosumab', 'Tuberculosis-tested-IFNG', 'Infections-tested-IFNG', 'Inflammation-perform-Cardiovascular Diseases', 'SIRT6-perform-Glucose', 'SIRT6-perform-Inflammation', 'SIRT6-perform-Cardiovascular Diseases', 'Glucose-perform-Cardiovascular Diseases', 'Muscular Diseases-observed-Diabetes Mellitus', 'Muscular Diseases-observed-Obesity', 'Muscular Diseases-observed-INS', 'LRRK1-treat-Osteoporosis', 'LRRK1-treat-Osteoporotic Fractures', 'Hemolytic-Uremic Syndrome-be in-Renal Insufficiency, Chronic', 'Hemolytic-Uremic Syndrome-activate-AHR', 'Renal Insufficiency, Chronic-activate-AHR', 'Alzheimer Disease-result-Atrophy', 'Alzheimer Disease-result-Death', 'Epilepsy, Absence-accompanied-Atrophy', 'Epilepsy, Absence-accompanied-Neurogenic Inflammation', 'Alzheimer Disease-result-MAPT', 'Inflammation-contribute-Pain', 'Diabetes Mellitus-with patient be-CRP', 'Pain-accompanied-CRP', 'Gerstmann-Straussler-Scheinker Disease-reveal-rs74315408', 'Creutzfeldt-Jakob Syndrome-reveal-rs74315408', 'Non-alcoholic Fatty Liver Disease-characterized-Triglycerides', 'Liver Diseases-characterized-Triglycerides', 'Inflammation-be important for-Death', 'Genetic Diseases, Inborn-associated-Fasciculation', 'Fasciculation-associated-Genetic Diseases, Inborn', 'Genetic Diseases, Inborn-associated-Metabolic Diseases', 'Metabolic Diseases-associated-Genetic Diseases, Inborn', 'Genetic Diseases, Inborn-associated-Cardiovascular Abnormalities', 'Cardiovascular Abnormalities-associated-Genetic Diseases, Inborn', 'LMNA-cause-Genetic Diseases, Inborn', 'LMNA-cause-Fasciculation', 'LMNA-cause-Metabolic Diseases', 'LMNA-cause-Cardiovascular Abnormalities', 'Sleep Initiation and Maintenance Disorders-prognosis of-Alzheimer Disease', 'Sleep Initiation and Maintenance Disorders-influence-Alzheimer Disease', 'Sleep Initiation and Maintenance Disorders-intensify-MAPT', 'Alzheimer Disease-intensify-MAPT', 'Vasculitis-prevent-Bone Diseases, Metabolic', 'Vasculitis-associated-MPO', 'MPO-associated-Vasculitis', 'MPO-prevent-Bone Diseases, Metabolic', 'Fractures, Bone-use-H19', 'H19-associated-Sarcopenia', 'Sarcopenia-associated-H19', 'INS-prevent-Diabetes Mellitus', 'HRAS-show-Heart Arrest', 'DLGAP2-observed-Alzheimer Disease', 'Metabolic Syndrome-dampen-Inflammation', 'Hyaluronic Acid-give-Eyelid Diseases', 'Metabolic Syndrome-improve-Cardiovascular Diseases', 'Hypertension-dampen-Inflammation', 'Hypertension-improve-Cardiovascular Diseases', 'Inflammation-improve-Cardiovascular Diseases', 'Metabolic Syndrome-treat-INS', 'Hypertension-treat-INS', 'INS-dampen-Inflammation', 'INS-improve-Cardiovascular Diseases', 'HIV Infections-alter-Dyslipidemias', 'HIV Infections-contribute-Dyslipidemias', 'HIV Infections-contribute-Weight Gain', 'Weight Gain-contribute-Dyslipidemias', 'INS-contribute-Dyslipidemias', 'PCSK9-be in-Aneurysm', 'PCSK9-contribute-Coronary Artery Disease', 'Sugars-account-Inflammation', 'PCSK9-contribute-Atherosclerosis', 'Sugars-account-Chronic Disease', 'Atherosclerosis-support-PCSK9', 'Intracranial Aneurysm-support-PCSK9', 'PCSK9-contribute-Vasculitis', 'Nocardia Infections-result-Hyponatremia', 'Amoxicillin-Potassium Clavulanate Combination-started-Nocardia Infections', 'Amoxicillin-Potassium Clavulanate Combination-result-Hyponatremia', 'Necrosis-shown-Dementia', 'TNF-shown-Dementia', 'Sleep Apnea, Obstructive-associated-Alzheimer Disease', 'Alzheimer Disease-associated-Sleep Apnea, Obstructive', 'Sleep Apnea, Obstructive-associated-MAPT', 'MAPT-associated-Sleep Apnea, Obstructive', 'VSIR-discuss-Neurodegenerative Diseases', 'ALB-remain-Death', 'Peripheral Arterial Disease-increased-Inflammation', 'CCL5-increased-Peripheral Arterial Disease', 'CCL5-increased-Inflammation', 'Dyslipidemias-identified-Meibomian Gland Dysfunction', 'Triglycerides-identified-Meibomian Gland Dysfunction', 'Dyslipidemias-decrease-Meibomian Gland Dysfunction', 'Triglycerides-have decrease-Meibomian Gland Dysfunction', 'Dyslipidemias-be independent protective factors for-Meibomian Gland Dysfunction', 'Triglycerides-presence of-Kidney Diseases', 'Triglycerides-be independent protective factors for-Meibomian Gland Dysfunction', 'Sleep Wake Disorders-associated-Kidney Diseases', 'Kidney Diseases-associated-Sleep Wake Disorders', 'Sleep Wake Disorders-associated-Glucose', 'Glucose-associated-Sleep Wake Disorders', 'Sleep Wake Disorders-associated-Triglycerides', 'Triglycerides-associated-Sleep Wake Disorders', 'Atherosclerosis-associated-Neurodegenerative Diseases', 'Neurodegenerative Diseases-associated-Atherosclerosis', 'Glucose-associated-Neurodegenerative Diseases', 'Neurodegenerative Diseases-associated-Glucose', 'Aneurysm-related-Alzheimer Disease', 'Aneurysm-related-MAPT', 'Genetic Diseases, Inborn-known-Progeria', 'LMNA-suffer-Genetic Diseases, Inborn', 'LMNA-known-Progeria', 'MAPT-be responsible by-Neurodegenerative Diseases', 'MAPT-contribute-Neurodegenerative Diseases', 'MAPT-contribute-Nerve Degeneration', 'Fatty Liver-associated-Metabolic Syndrome', 'Metabolic Syndrome-associated-Fatty Liver', 'MAPT-contribute-Inflammation', 'Fatty Liver-associated-INS', 'INS-associated-Fatty Liver', 'Metabolic Diseases-play-Diabetes Mellitus, Type 2', 'Dyslipidemias-play-Diabetes Mellitus, Type 2', 'Hyperinsulinism-play-Diabetes Mellitus, Type 2', 'INS-play-Diabetes Mellitus, Type 2', 'Adenocarcinoma of Lung-identified-Lung Neoplasms', 'Adenocarcinoma of Lung-identified-Prostatitis', 'Adenocarcinoma of Lung-identified-Pancreatitis', 'Adenocarcinoma of Lung-identified-Sarcoma', 'Adenocarcinoma of Lung-identified-Multiple Myeloma', 'Adenocarcinoma of Lung-identified-Lymphoma', 'Pancreatitis-include-Neoplasms', 'Sarcoma-include-Neoplasms', 'Multiple Myeloma-include-Neoplasms', 'Lymphoma-include-Neoplasms', 'Sugars-cause-Diabetes Mellitus', 'Sugars-cause-Hyperglycemia', 'MALAT1-identified-Lung Neoplasms', 'MALAT1-identified-Prostatitis', 'MALAT1-identified-Pancreatitis', 'MALAT1-identified-Sarcoma', 'MALAT1-identified-Multiple Myeloma', 'MALAT1-identified-Lymphoma', 'Lymphopenia-predict-Death', 'Blood Platelet Disorders-linked-Rupture', 'Blood Platelet Disorders-linked-Arachidonic Acid', 'Arachidonic Acid-linked-Rupture', 'Atherosclerosis-originated-EREG', 'Glycosaminoglycans-contribute-Neurologic Manifestations', 'Glycosaminoglycans-contribute-Death', 'Mitochondrial Diseases-lead-Metabolic Diseases', 'Mitochondrial Diseases-lead-INS', 'Alzheimer Disease-consider-Disease', 'MAPT-consider-Alzheimer Disease', 'MAPT-consider-Disease', 'Atherosclerosis-associated-Parkinson Disease, Secondary', 'Parkinson Disease, Secondary-associated-Atherosclerosis', 'Arteriolosclerosis-associated-Parkinson Disease, Secondary', 'Parkinson Disease, Secondary-associated-Arteriolosclerosis', 'Cerebral Amyloid Angiopathy-associated-Parkinson Disease, Secondary', 'Parkinson Disease, Secondary-associated-Cerebral Amyloid Angiopathy', 'Alzheimer Disease-associated-Parkinson Disease, Secondary', 'Parkinson Disease, Secondary-associated-Alzheimer Disease', 'Sclerosis-associated-Parkinson Disease, Secondary', 'Parkinson Disease, Secondary-associated-Sclerosis', 'Inflammation-contribute-Dementia', 'TARDBP-associated-Parkinson Disease, Secondary', 'Parkinson Disease, Secondary-associated-TARDBP', 'Inflammation-contribute-Chronic Traumatic Encephalopathy', 'Inflammation-contribute-Headache Disorders, Secondary', 'Arteriolosclerosis-contribute-Dementia', 'Arteriolosclerosis-contribute-Chronic Traumatic Encephalopathy', 'Dementia-contribute-Chronic Traumatic Encephalopathy', 'Dementia-contribute-Headache Disorders, Secondary', 'MAPT-contribute-Dementia', 'MAPT-contribute-Chronic Traumatic Encephalopathy', 'Chronic Traumatic Encephalopathy-experience-Craniocerebral Trauma', 'Immunologic Deficiency Syndromes-contribute to-Bronchopulmonary Dysplasia', 'Immunologic Deficiency Syndromes-contribute to-Hypertension, Pulmonary', 'MAPT-experience-Craniocerebral Trauma', 'KL-contribute to-Bronchopulmonary Dysplasia', 'KL-contribute to-Hypertension, Pulmonary', 'Nerve Degeneration-consist with-MAPT', 'BMI1-be unique to-Alzheimer Disease', 'KL-preserve-Hypertension, Pulmonary', 'KL-preserve-Vascular Remodeling', 'Pneumonia-associate-Inflammation', 'Inflammation-associate-Pneumonia', 'Inflammation-treat-Respiratory Distress Syndrome', 'Pneumonia-treat-Respiratory Distress Syndrome', 'LMNA-include-Cardiomyopathy, Dilated', 'LMNA-include-Muscular Dystrophies', 'LMNA-termed-Progeria', 'MAPT-posttranslational deamidation of be-Alzheimer Disease', 'MAPT-posttranslational deamidation of be-Supranuclear Palsy, Progressive', 'Glucose-mediated-Chemical and Drug Induced Liver Injury', 'PPM1D-treat-Neoplasms', 'PPM1D-treat-Immune System Diseases', 'PPM1D-treat-Asthma', 'Weight Loss-be in-Diabetes Mellitus', 'GDF15-associated-Weight Loss', 'Weight Loss-associated-GDF15', 'GDF15-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-GDF15', 'Mitochondrial Diseases-lead-Diabetes Mellitus', 'Wounds and Injuries-invoke-Edema', 'Wounds and Injuries-present-INS', 'Parkinson Disease-have show-Carcinoma, Merkel Cell', 'Diverticulitis-explore-SERPINA1', 'Disease-explore-SERPINA1', 'CETN1-associated-Alzheimer Disease', 'Alzheimer Disease-associated-CETN1', 'Glucose Metabolism Disorders-define-Alzheimer Disease', 'Glucose Metabolism Disorders-measured-Fluorodeoxyglucose F18', 'Fluorodeoxyglucose F18-define-Alzheimer Disease', 'HUWE1-be in-Neoplasms', 'Wounds and Injuries-induced-Death', 'Death-associated-ACE2', 'ACE2-associated-Death', 'von Willebrand Diseases-be quantitative or qualitative defect in-Headache Disorders, Secondary', 'von Willebrand Diseases-result-Headache Disorders, Secondary', 'von Willebrand Diseases-result-Hemorrhage', 'von Willebrand Diseases-result-Wounds and Injuries', 'Headache Disorders, Secondary-result-Wounds and Injuries', 'Hemorrhage-result-Wounds and Injuries', 'von Willebrand Diseases-be quantitative or qualitative defect in-VWF', 'VWF-result-Wounds and Injuries', 'Death-adjusted-Diabetes Mellitus', 'Death-adjusted-Cardiovascular Diseases', 'Leukemia-include-Neoplasms', 'Death-adjusted-CRP', 'KL-alleviate-Inflammation', 'KL-alleviate-Neuroblastoma', 'Telangiectasis-characterized-Neurodegenerative Diseases', 'ATM-result-Neurodegenerative Diseases', 'ATM-characterized-Neurodegenerative Diseases', 'Diabetes Mellitus-develop-Kidney Failure, Chronic', 'Diabetes Mellitus-develop-Dementia', 'Diabetes Mellitus-develop-Vision Disorders', 'Brain Neoplasms-highlight-Glioblastoma', 'Neoplasms-highlight-Glioblastoma', 'IDO1-highlight-Glioblastoma', 'IDO1-highlight-Brain Neoplasms', 'IDO1-reside-Brain Neoplasms', 'IDO1-highlight-Neoplasms', 'IDO1-reside-Neoplasms', 'NEFL-associated-Atrophy', 'Atrophy-associated-NEFL', 'NEFL-correlate-Atrophy', 'Diabetic Cardiomyopathies-include-Heart Diseases', 'Cardiotoxicity-include-Heart Diseases', 'Anthracyclines-include-Heart Diseases', 'Fatty Acids, Omega-3-use-Coronary Artery Disease', 'Fatty Acids, Omega-3-use-Heart Failure', 'CRP-show-Cardiomyopathies', 'CX3CL1-upregulated-Delirium', 'CX3CL1-upregulated-Alzheimer Disease', 'Critical Illness-develop-Neurodegenerative Diseases', 'REM Sleep Behavior Disorder-be specific marker of-Synucleinopathies', 'REM Sleep Behavior Disorder-develop-Neurodegenerative Diseases', 'Synucleinopathies-develop-Neurodegenerative Diseases', 'Delirium-include-CD200R1', 'Alzheimer Disease-include-CD200R1', 'Amyotrophic Lateral Sclerosis-accompanied-VWF', 'INS-include-Metabolic Diseases', 'Tramadol-reduce-Postoperative Nausea and Vomiting', 'Tramadol-reduce-Vomiting', 'INS-treat-Alzheimer Disease', 'Tramadol-reduce-Xerostomia', 'INS-treat-Dementia', 'PNPLA2-cause-Triglycerides', 'PNPLA2-cause-Muscular Diseases', 'Cardiovascular Diseases-use-Hemorrhage', 'CRP-assess-Alzheimer Disease', 'Cerebral Infarction-use-Hemorrhage', 'Stroke-use-Hemorrhage', 'rs12041331-use-Hemorrhage', 'Glucose-exacerbated-INS', 'Prostatic Hyperplasia-exacerbated-INS', 'Prostatic Neoplasms-exacerbated-INS', 'Glucose-promote EMT process in-Prostatic Hyperplasia', 'Glucose-promote-Prostatic Neoplasms', 'Neurologic Manifestations-contribute-Neurodegenerative Diseases', 'ALB-decreased-Hypotension', 'Arthralgia-prevent-Joint Diseases', 'Arthralgia-treated-Hyaluronic Acid', 'Hyaluronic Acid-prevent-Joint Diseases', 'ABO-associated-Hemorrhage', 'Hemorrhage-associated-ABO', 'ABO-associated-Death', 'Death-associated-ABO', 'Death-done-Hemorrhage', 'Death-give-Cardiovascular Diseases', 'Death-give-Thromboembolism', 'Death-give-Infections', 'Hemorrhage-include-Cardiovascular Diseases', 'Hemorrhage-include-Thromboembolism', 'Hemorrhage-include-Infections', 'RARRES2-act as-Obesity', 'Hypertension-favor-Arbovirus Infections', 'RARRES2-act-Intervertebral Disc Degeneration', 'Hemorrhage-include-ABO', 'Hypertension-influence-ACE2', 'Eclampsia-include-ABO', 'Cardiovascular Diseases-include-ABO', 'ACE2-favor-Arbovirus Infections', 'Thromboembolism-include-ABO', 'Infections-include-ABO', 'Inflammation-act-Hypoglycemia', 'Fatty Acids-bind-Inflammation', 'Fatty Acids-bind-Neoplasms', 'Fatty Acids-inhibit-Atherosclerosis', 'AFP-presence of-Neoplasms', 'Doxorubicin-trigger-Death', 'Doxorubicin-result-Tremor', 'APOE-increase-Coronary Artery Disease', 'APOE-associated-Coronary Artery Disease', 'Coronary Artery Disease-associated-APOE', 'MAPT-be driver of-Atrophy', 'MAPT-provide-Alzheimer Disease', 'MAPT-associated-Atrophy', 'Atrophy-associated-MAPT', 'Obesity-accumulate-Drug-Related Side Effects and Adverse Reactions', 'Fatty Acids-obtained-Obesity', 'Fatty Acids-accumulate-Drug-Related Side Effects and Adverse Reactions', 'Diabetes Mellitus-characterized-Glucose', 'Metabolic Diseases-characterized-Glucose', 'Memory Disorders-exhibit-Myositis', 'Osteoporotic Fractures-reduce-Fractures, Bone', 'Denosumab-prevent-Osteoporotic Fractures', 'Denosumab-reduce-Fractures, Bone', 'PDGFRB-separate-Myofibroma', 'SIRT1-lead-Osteoarthritis', 'Hantavirus Pulmonary Syndrome-contribute-Fractures, Bone', 'Hantavirus Pulmonary Syndrome-contribute-Denosumab', 'Denosumab-contribute-Fractures, Bone', 'Neoplasms-induce-Heart Arrest', 'Hyperplasia-promote-Neoplasms', 'CDKN2A-induce-Heart Arrest', 'CDKN2A-induce-Hyperplasia', 'CDKN2A-promote-Neoplasms', 'Alzheimer Disease-impact-Lipid Metabolism Disorders', 'MGLL-impact-Lipid Metabolism Disorders', 'MGLL-identify-Urinary Bladder, Neurogenic', 'MGLL-impair-Urinary Bladder, Neurogenic', 'Cerebrovascular Disorders-subsequence-Hematologic Diseases', 'MGLL-identify-Alzheimer Disease', 'MGLL-impair-Alzheimer Disease', 'MGLL-identify-Diabetes Mellitus', 'MGLL-identify-Memory Disorders', 'MGLL-prevent-Memory Disorders', 'MTOR-contribute to-Cerebrovascular Disorders', 'MTOR-subsequence-Hematologic Diseases', 'MTOR-drive-Cerebrovascular Disorders', 'MTOR-drive-Alzheimer Disease', 'Hyperkinesis-protect-Alzheimer Disease', 'MTOR-protect-Alzheimer Disease', 'Parkinson Disease-underlined-Neurodegenerative Diseases', 'Oils-associated-Parkinson Disease', 'Parkinson Disease-associated-Oils', 'Oils-found-Neurodegenerative Diseases', 'MYSM1-colocalize-Etoposide', 'MYSM1-colocalize-Leukemia', 'Melanoma-identify-MYSM1', 'Melanoma-colocalize-MYSM1', 'Kidney Diseases-play-Renal Insufficiency, Chronic', 'Fibrosis-aid-Renal Insufficiency, Chronic', 'KL-alleviate-Heart Failure', 'KL-alleviate-Kidney Diseases', 'KL-serve-Fibrosis', 'KL-serve-Renal Insufficiency, Chronic', 'KL-aid-Renal Insufficiency, Chronic', 'KL-play-Renal Insufficiency, Chronic', 'KL-alleviate-Acute Kidney Injury', 'Diabetes Mellitus, Type 2-associated-IAPP', 'IAPP-associated-Diabetes Mellitus, Type 2', 'Thrombosis-illuminate-IL6', 'Death-illuminate-IL6', 'Glutathione-justify-Infections', 'Mitochondrial Diseases-involve-Acute Kidney Injury', 'Heart Arrest-involve-Acute Kidney Injury', 'Mitochondrial Diseases-involve-Renal Insufficiency, Chronic', 'Heart Arrest-involve-Renal Insufficiency, Chronic', 'Diabetes Mellitus-risk of-Death', 'Phosphatidylcholines-associated-Neurodegenerative Diseases', 'Neurodegenerative Diseases-associated-Phosphatidylcholines', 'Phosphatidylcholines-associated-Glucose Metabolism Disorders', 'Glucose Metabolism Disorders-associated-Phosphatidylcholines', 'Ascorbic Acid-related-Parkinsonian Disorders', 'Neurodegenerative Diseases-be in-Alzheimer Disease', 'RELN-postulated-Neurodegenerative Diseases', 'RELN-postulated-Alzheimer Disease', 'RELN-be in-Neurodegenerative Diseases', 'RELN-be in-Alzheimer Disease', 'RELN-measure-Dementia', 'Dry Eye Syndromes-combined-Cataract', 'Hyaluronic Acid-combined-Dry Eye Syndromes', 'Lupus Erythematosus, Systemic-show-C3', 'Lupus Nephritis-show-C3', 'Hyaluronic Acid-combined-Cataract', 'Respiratory Tract Infections-cause-Infections', 'Respiratory Tract Infections-cause-ACE2', 'Sinus Arrest, Cardiac-base-Sick Sinus Syndrome', 'Sick Sinus Syndrome-shared-Bradycardia', 'Sick Sinus Syndrome-shared-rs137854618', 'Sinus Arrest, Cardiac-base-SCN5A', 'Sinus Arrest, Cardiac-base-rs137854618', 'Pneumonia-amended-Pneumococcal Infections', 'Polysaccharides-amended-Pneumonia', 'Alzheimer Disease-pathological feature of be-Neurotoxicity Syndromes', 'Inflammation-be in-Leukemia, Myeloid, Acute', 'MIR146A-identify-Inflammation', 'MIR146A-identify-Leukemia, Myeloid, Acute', 'Dementia-include-MAPT', 'Inflammation-promote-Carcinogenesis', 'CFH-lead-Inflammation', 'CFH-promote-Carcinogenesis', 'Arrhythmias, Cardiac-be in-Communicable Diseases', 'Infliximab-generate-Arrhythmias, Cardiac', 'Infliximab-generate-Communicable Diseases', 'Neoplasms-include-Disease', 'Infections-include-Disease', 'KL-lead-Neurodegenerative Diseases', 'KL-lead-Alzheimer Disease', 'KL-lead-Parkinson Disease, Secondary', 'KL-lead-Amyotrophic Lateral Sclerosis', 'KL-lead-Demyelinating Diseases', 'KL-lead-Multiple Sclerosis', 'Carotid Artery Diseases-impair-Glucose Intolerance', 'Carotid Artery Diseases-impair-Hypertension', 'Carotid Artery Diseases-impair-CRP', 'SIRT1-involved-Coronaviridae Infections', 'SIRT1-involved-Diabetes Mellitus, Type 2', 'SIRT1-involved-Neoplasms', 'SIRT1-involved-Obesity', 'PARN-xenotransplanted-Immunologic Deficiency Syndromes', 'MGP-be potent inhibitor of-Vascular Calcification', 'MGP-be potent inhibitor of-Calcinosis', 'Renal Insufficiency-associated-Anemia', 'Anemia-associated-Renal Insufficiency', 'Glutathione-observed-Nervous System Diseases', 'Glutathione-observed-Alzheimer Disease', 'Glutathione-observed-Parkinson Disease', 'Obesity-associated-Chemical and Drug Induced Liver Injury', 'Chemical and Drug Induced Liver Injury-associated-Obesity', 'Renal Insufficiency-be in-Chronic Kidney Disease-Mineral and Bone Disorder', 'TP53-associated-Neoplasms', 'Neoplasms-associated-TP53', 'TP53-associated-Carcinoma, Hepatocellular', 'Carcinoma, Hepatocellular-associated-TP53', 'Obesity-define-Ataxia', 'INS-define-Obesity', 'INS-investigate-Ataxia', 'SIRT1-reduce-Inflammation', 'SIRT1-increase-Pulmonary Disease, Chronic Obstructive', 'ALOX12-found-Carcinoma, Pancreatic Ductal', 'ALOX12-found-Neoplasms', 'TAT-be responsible for-Fibrosis', 'MAPT-found-Alzheimer Disease', 'LEPR-identified-Osteoarthritis', 'Chiari-Frommel Syndrome-include-Substance-Related Disorders', 'Chiari-Frommel Syndrome-treat-Substance-Related Disorders', 'LEPR-identified-Osteoporotic Fractures', 'Chiari-Frommel Syndrome-include-PRL', 'Chiari-Frommel Syndrome-measure-PRL', 'PRL-include-Substance-Related Disorders', 'PRL-treat-Substance-Related Disorders', 'MAPT-control-Hypertension', 'MAPT-control-Hyperlipidemias', 'MAPT-control-Diabetes Mellitus', 'MAPT-control-Sleep Wake Disorders', 'SIRT7-detected-Leukemia, Myeloid, Acute', 'SIRT7-detected-Leukemia, Myelogenous, Chronic, BCR-ABL Positive', 'Lipodystrophy-acquired-Acquired Immunodeficiency Syndrome', 'Lipodystrophy-treat-Acquired Immunodeficiency Syndrome', 'Lipodystrophy-result-HIV Infections', 'Acquired Immunodeficiency Syndrome-used-HIV Infections', 'Lipodystrophy-result-ZMPSTE24', 'Acquired Immunodeficiency Syndrome-used-ZMPSTE24', 'Obesity-lead-Diabetes Mellitus', 'Kidney Calculi-of formation be-Dehydration', 'Kidney Calculi-aggravated-Dehydration', 'Hemorrhage-correlated-Stroke', 'BSG-correlated-Hemorrhage', 'Leukemia, Myeloid, Acute-restore-SIRT7', 'BSG-correlated-Stroke', 'ALB-associated-Anorexia', 'Anorexia-associated-ALB', 'Leukemia, Myelogenous, Chronic, BCR-ABL Positive-restore-SIRT7', 'Neoplasms-improve-Neurodegenerative Diseases', 'HSPB1-used-Neoplasms', 'HSPB1-improve-Neurodegenerative Diseases', 'Obesity-associate-Hyperuricemia', 'Hyperuricemia-associate-Obesity', 'Obesity-increase-Hyperuricemia', 'Hypertension-associate-Hyperuricemia', 'Hyperuricemia-associate-Hypertension', 'Hypertension-increase-Hyperuricemia', 'Dyslipidemias-associate-Hyperuricemia', 'Hyperuricemia-associate-Dyslipidemias', 'Dyslipidemias-increase-Hyperuricemia', 'ABCG2-associate-Hyperuricemia', 'Hyperuricemia-associate-ABCG2', 'ABCG2-increase-Hyperuricemia', 'rs2231142-associate-Hyperuricemia', 'Hyperuricemia-associate-rs2231142', 'rs2231142-increase-Hyperuricemia', 'WDFY3-be genetic modifier of-Huntington Disease', 'Giant Cell Arteritis-base-Vasculitis', 'Giant Cell Arteritis-base-Fluorodeoxyglucose F18', 'INS-link-Glucose Intolerance', 'SIRT5-associated-Melanoma', 'Melanoma-associated-SIRT5', 'SIRT5-associated-Carcinoma, Basal Cell', 'Carcinoma, Basal Cell-associated-SIRT5', 'SIRT5-associated-Carcinoma, Squamous Cell', 'Carcinoma, Squamous Cell-associated-SIRT5', 'SIRT4-connected-Carcinoma, Basal Cell', 'BDNF-be in-Inflammation', 'BDNF-associated-Inflammation', 'Inflammation-associated-BDNF', 'SIRT4-connected-Carcinoma, Squamous Cell', 'SIRT3-study-Scleroderma, Systemic', 'SIRT3-study-Melanoma', 'SIRT3-study-Carcinoma, Basal Cell', 'SIRT3-study-Carcinoma, Squamous Cell', 'rs2431697-associated-Primary Myelofibrosis', 'Primary Myelofibrosis-associated-rs2431697', 'rs2431697-associated-Polycythemia Vera', 'Polycythemia Vera-associated-rs2431697', 'rs2431697-associated-Thrombocythemia, Essential', 'Thrombocythemia, Essential-associated-rs2431697', 'Primary Myelofibrosis-progress-rs2431697', 'Renal Insufficiency, Chronic-ratified-Kidney Diseases', 'CST3-ratified-Kidney Diseases', 'Neurodegenerative Diseases-encompass-Mitochondrial Diseases', 'Neurodegenerative Diseases-encompass-INS', 'Obesity, Abdominal-associated-Cholesterol', 'Cholesterol-associated-Obesity, Abdominal', 'Obesity-treat-Cardiovascular Diseases', 'Obesity-ameliorate-Nervous System Diseases', 'Cardiovascular Diseases-ameliorate-Nervous System Diseases', 'Anserine-ameliorate-Nervous System Diseases', 'FNDC5-decreased-Diabetes Mellitus', 'FNDC5-upregulate in-Obesity', 'FNDC5-upregulate-Glucose Intolerance', 'Thrombosis-evaluate-Enoxaparin', 'Hyperglycemia-cause-Fatigue', 'Hyperglycemia-cause-Glucose', 'Ventricular Remodeling-be in-Hypertension', 'Triglycerides-elevated-Metabolic Syndrome', 'Triglycerides-carry-Cardiomyopathies', 'Triglycerides-carry-Atrial Fibrillation', 'MAPK8-play-Chemical and Drug Induced Liver Injury', 'NPY-decrease-Progeria', 'Atherosclerosis-affected-Arteriosclerosis', 'Atherosclerosis-affected-ACE', 'Neoplasms-be in-Breast Neoplasms', 'Neoplasms-deleted-Multiple Myeloma', 'Neoplasms-shown-Amyloidosis', 'GLIPR1-deleted-Multiple Myeloma', 'GLIPR1-inhibit-Neoplasms', 'GLIPR1-shown-Amyloidosis', 'GLIPR1-shown-Neoplasms', 'MAPT-correlate-Alzheimer Disease', 'KL-factor for-Cardiovascular Diseases', 'Carcinoma, Pancreatic Ductal-compare-Neoplasms', 'Dyskeratosis Congenita-caused-NHP2', 'Tibial Meniscus Injuries-protect-Osteoarthritis', 'FOXO1-protect-Tibial Meniscus Injuries', 'FOXO1-support-Osteoarthritis', 'Leukoencephalopathies-be in-Stroke, Lacunar', 'CRP-associated-Arthritis', 'Arthritis-associated-CRP', 'Infarction-undergo-Coronary Artery Disease', 'Cyclosporine-reduce-Infarction', 'Cyclosporine-evaluate-Coronary Artery Disease', 'DEPP1-identified-Retinal Diseases', 'DEPP1-connect-Retinal Diseases', 'Alzheimer Disease-exhibit-Sleep Wake Disorders', 'INS-be crucial determinants of-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-Arthritis, Rheumatoid', 'Arthritis, Rheumatoid-associated-Cardiovascular Diseases', 'Fatty Acids, Omega-3-counteract-Myalgia', 'Arthritis, Rheumatoid-improve-Metabolic Diseases', 'Fatty Acids, Omega-3-counteract-Arthritis, Rheumatoid', 'Arthritis, Rheumatoid-limit-Muscular Atrophy', 'Arthritis, Rheumatoid-increased-Cardiovascular Diseases', 'Metabolic Syndrome-associated-Arthritis, Rheumatoid', 'Arthritis, Rheumatoid-associated-Metabolic Syndrome', 'Arthritis, Rheumatoid-exhibit-Cholesterol', 'Arthritis, Rheumatoid-limit-Obesity', 'Metabolic Diseases-limit-Obesity', 'MYOD1-restore-Idiopathic Pulmonary Fibrosis', 'MTOR-implicated-Metabolic Diseases', 'Cholesterol-increased-Cardiovascular Diseases', 'MYOD1-silence-Fibrosis', 'MTOR-implicated-Neurodegenerative Diseases', 'Muscular Atrophy-limit-Obesity', 'Fatty Acids, Omega-3-prevent-Arthritis, Rheumatoid', 'INS-associated-Arthritis, Rheumatoid', 'Arthritis, Rheumatoid-associated-INS', 'Fatty Acids, Omega-3-improve-Metabolic Diseases', 'Fatty Acids, Omega-3-limit-Muscular Atrophy', 'Fatty Acids, Omega-3-limit-Obesity', 'INS-have emerge as-Diabetes Mellitus, Type 2', 'KL-occur-Neurodegenerative Diseases', 'KL-occur-Kidney Diseases', 'KL-occur-Neoplasms', 'AGER-induced-Hyperlipidemias', 'TP53-remain-Neoplasms', 'TP53-implicated-Neoplasms', 'TP53-implicated-Leukemia, Myeloid, Acute', 'AGER-play role in-Atherosclerosis', 'AGER-play role in-Diabetes Mellitus', 'AGER-treat-Diabetes Mellitus', 'AGER-treat-Diabetic Angiopathies', 'Death-be reasons for-Prediabetic State', 'Death-be reasons for-Diabetes Mellitus', 'Death-be reasons for-Glucose', 'Pituitary Neoplasms-harbor-Genetic Diseases, Inborn', 'Pituitary Neoplasms-harbor-MEN1', 'Genetic Diseases, Inborn-harbor-MEN1', 'Alzheimer Disease-indicate-Nervous System Diseases', 'Alzheimer Disease-show-MAPT', 'Inflammation-increase-Atherosclerosis', 'Inflammation-increase-INS', 'Alzheimer Disease-characterized-MAPT', 'Glutathione-reported-Neurodegenerative Diseases', 'Glutathione-reported-Cardiovascular Diseases', 'Glutathione-reported-Metabolic Diseases', 'Diabetes Mellitus-use-AP2B1', 'Alzheimer Disease-characterized-Docosahexaenoic Acids', 'Neurodegenerative Diseases-characterized-Docosahexaenoic Acids', 'Alzheimer Disease-use-Neurodegenerative Diseases', 'HSPD1-use-Neurodegenerative Diseases', 'Diabetes Mellitus-demonstrate-Skin Diseases', 'Skin Diseases-be common complications among-Diabetes Mellitus', 'Diabetes Mellitus-contain-Ceramides', 'Ceramides-contain-Skin Diseases', 'Ovarian Diseases-correlate-Infertility, Female', 'INS-promote-Ovarian Diseases', 'Ceramides-lead-Skin Diseases', 'Ceramides-lead-Diabetes Mellitus', 'Death-obtained-Alzheimer Disease', 'TARDBP-obtained-Alzheimer Disease', 'TGFA-induce-Seizures', 'Lung Neoplasms-use-Bevacizumab', 'Neoplasm Metastasis-use-Bevacizumab', 'Neoplasms-used-Neoplasm Metastasis', 'Neoplasms-treated-Bevacizumab', 'Bevacizumab-associated-Death', 'Death-associated-Bevacizumab', 'Bevacizumab-associated-Neoplasm Metastasis', 'Neoplasm Metastasis-associated-Bevacizumab', 'Neoplasm Metastasis-treated-Bevacizumab', 'Neoplasm Metastasis-do-Intracranial Arterial Diseases', 'Hypoxia-indicate-Dyslipidemias', 'Neoplasm Metastasis-minimize-Brain Edema', 'Niemann-Pick Disease, Type A-coupled-Dyslipidemias', 'Hypoxia-indicate-Obesity', 'Obesity-coupled-Ceramides', 'Intracranial Arterial Diseases-minimize-Brain Edema', 'Bevacizumab-benefit-Neoplasm Metastasis', 'Ceramides-coupled-Dyslipidemias', 'Bevacizumab-do-Intracranial Arterial Diseases', 'Hypoxia-opening-Sphingolipids', 'Dyslipidemias-opening-Sphingolipids', 'Bevacizumab-minimize-Brain Edema', 'Obesity-opening-Sphingolipids', 'Osteoporotic Fractures-respond-BMP2', 'Osteoarthritis-respond to-BMP2', 'CRP-measured-Coronary Artery Disease', 'Metabolic Diseases-be primary feature of-Werner Syndrome', 'Metabolic Diseases-be primary feature of-Aging, Premature', 'Paralysis-include-Amyotrophic Lateral Sclerosis', 'Retinal Degeneration-provide-Amyotrophic Lateral Sclerosis', 'GPX7-protect-Retinal Degeneration', 'GPX7-provide-Amyotrophic Lateral Sclerosis', 'Carcinoma-be in-Pulmonary Fibrosis', 'Renal Insufficiency, Chronic-include-Cardiovascular Diseases', 'DNER-evaluated-Cardiovascular Diseases', 'DNER-evaluated-Renal Insufficiency, Chronic', 'Death-implicate in-Cardiovascular Diseases', 'Cardiovascular Diseases-be in-Renal Insufficiency, Chronic', 'Death-implicate in-Renal Insufficiency, Chronic', 'Huntington Disease-characterized-Neurodegenerative Diseases', 'HTT-characterized-Huntington Disease', 'HTT-characterized-Neurodegenerative Diseases', 'KDM6B-studied-Communicable Diseases', 'KDM6B-studied-Neoplasms', 'Carcinoma, Hepatocellular-associated-Viremia', 'Viremia-associated-Carcinoma, Hepatocellular', 'Carcinoma, Hepatocellular-associated-CD4', 'CD4-associated-Carcinoma, Hepatocellular', 'Diabetes Mellitus-include-Obesity', 'Glucose-include-Obesity', 'Glucose-accord-Diabetes Mellitus', 'MAP3K5-play role in-Cardiovascular Diseases', 'Parkinson Disease-linked-Death', 'MAPT-be microtubule associated protein-Neurodegenerative Diseases', 'Epilepsy-underlie-Lafora Disease', 'Epilepsy-favor-Seizures', 'Glycogen-underlie-Epilepsy', 'Ceramides-differ accord-Fractures, Bone', 'Ceramides-differ-Hip Fractures', 'Pheochromocytoma-include-Neuroendocrine Tumors', 'Neuroblastoma-include-Neuroendocrine Tumors', 'Lafora Disease-formed-Glycogen', 'Neurotoxicity Syndromes-be major pathogenic trait of-Parkinson Disease', 'Cardiomyopathies-promote-AGER', 'Alzheimer Disease-protect-Tauopathies', 'ADNP-protect-Alzheimer Disease', 'ADNP-protect-Tauopathies', 'Alzheimer Disease-frequency to-Tauopathies', 'Alzheimer Disease-correlate-Tauopathies', 'ADNP-frequency to-Tauopathies', 'ADNP-be in-Alzheimer Disease', 'ADNP-show-Alzheimer Disease', 'Glucose-focus-Neoplasms', 'Glucose-link-Neoplasms', 'Fatty Acids-contribute-Sarcopenia', 'Fatty Acids-contribute-Muscular Diseases', 'Fatty Acids-contribute-Inflammation', 'MYPN-associated-Hypertrophy', 'Hypertrophy-associated-MYPN', 'MYPN-associated-Cardiomyopathies', 'Cardiomyopathies-associated-MYPN', 'MYPN-associated-Muscular Diseases', 'Muscular Diseases-associated-MYPN', 'MYPN-associated-Myopathies, Nemaline', 'Myopathies, Nemaline-associated-MYPN', 'MYPN-associated-Myotonia Congenita', 'Myotonia Congenita-associated-MYPN', 'Lung Neoplasms-correlated-Neoplasms', 'Carcinoma, Hepatocellular-correlated-Neoplasms', 'MAP4K3-correlated-Neoplasms', 'MAP4K3-be in-Neoplasms', 'MAP4K3-correlated-Lung Neoplasms', 'Carcinoma, Hepatocellular-correlated-MAP4K3', 'Aging, Premature-lead-Myocardial Infarction', 'Aging, Premature-lead-Stroke', 'Myocardial Infarction-caused-LMNA', 'Stroke-caused-LMNA', 'Alzheimer Disease-include-Obesity', 'Alzheimer Disease-include-Cholesterol', 'Cholesterol-stemm-Acute Kidney Injury', 'Anthocyanins-known-Neoplasms', 'Anthocyanins-known-Diabetes Mellitus', 'SIRT6-be higher In-Cerebral Infarction', 'SIRT6-be higher In-Stroke', 'Erectile Dysfunction-present-Metabolic Syndrome', 'Erectile Dysfunction-present-INS', 'Obesity-associated-Erectile Dysfunction', 'Erectile Dysfunction-associated-Obesity', 'Obesity-present-Erectile Dysfunction', 'Cholesterol-associated-Erectile Dysfunction', 'Erectile Dysfunction-associated-Cholesterol', 'Osteosarcoma-use-Neoplasms', 'MBTD1-use-Neoplasms', 'SIRT6-be in-Neoplasms', 'SLC1A2-associated-Alzheimer Disease', 'Alzheimer Disease-associated-SLC1A2', 'Amyloidosis-recognized-Death', 'Cardiomyopathies-recognized-Death', 'TTR-recognized-Death', 'Cholesterol-adjusted-APOE', 'APOE-adjusted-Cardiovascular Diseases', 'Cholesterol-associate-Cardiovascular Diseases', 'Cardiovascular Diseases-associate-Cholesterol', 'APOE-evaluate-Cardiovascular Diseases', 'APOE-evaluate-Death', 'Hyperkinesis-increase-Gait Disorders, Neurologic', 'MCHR1-found-Hyperkinesis', 'MCHR1-found-Gait Disorders, Neurologic', 'Bone Resorption-introduce-Osteoporosis', 'Bone Resorption-modulate-Osteoporosis', 'Bone Resorption-modulate-Osteoarthritis', 'Arthritis, Rheumatoid-introduce-Bone Resorption', 'Arthritis, Rheumatoid-treat-Bone Resorption', 'Arthritis, Rheumatoid-introduce-Osteoporosis', 'TNFSF11-introduce-Bone Resorption', 'TNFSF11-treat-Bone Resorption', 'TNFSF11-introduce-Osteoporosis', 'TNFSF11-introduce-Arthritis, Rheumatoid', 'FOXA1-be higher in-Breast Neoplasms', 'FOXA1-be higher than-Neoplasms', 'FOXA1-be higher in-Neoplasms', 'Inflammation-include-Diabetes Mellitus', 'MTOR-involved-Neoplasms', 'FAM13A-associated-Lung Diseases', 'Lung Diseases-associated-FAM13A', 'MTOR-involved-Cardiovascular Diseases', 'INS-implicated-Diabetes Mellitus, Type 2', 'FAM13A-associated-Lung Diseases, Obstructive', 'Lung Diseases, Obstructive-associated-FAM13A', 'INS-implicated-Neurodegenerative Diseases', 'FAM13A-associated-Pulmonary Fibrosis', 'Pulmonary Fibrosis-associated-FAM13A', 'FAM13A-show-Pulmonary Fibrosis', 'MTOR-involved-Neurodegenerative Diseases', 'MTOR-involved-Epilepsy', 'SLC2A1-associated-Carcinoma, Squamous Cell', 'Carcinoma, Squamous Cell-associated-SLC2A1', 'SLC2A1-associated-Neoplasms', 'Neoplasms-associated-SLC2A1', 'SLC2A1-associated-Neoplasm Metastasis', 'Neoplasm Metastasis-associated-SLC2A1', 'Low Back Pain-prescribed-Tramadol', 'Neoplasms-prescribed-Tramadol', 'REN-permit-Cardiovascular Diseases', 'REN-permit-Neoplasms', 'SIRT2-rescue-Cardiomyopathies', 'SIRT2-rescue-Neurodegenerative Diseases', 'MAPT-play role in-Alzheimer Disease', 'MAPT-play-Tauopathies', 'MIR532-known-Diabetes Mellitus', 'MIR532-known-Obesity', 'Metabolic Syndrome-involved-Polycystic Ovary Syndrome', 'Obesity-involved-Polycystic Ovary Syndrome', 'INS-involved-Polycystic Ovary Syndrome', 'Hypoxia-improve-Ischemia', 'Hypoxia-promote-VEGFA', 'Ischemia-promote-VEGFA', 'Cholesterol-considered-Dyslipidemias', 'MAPT-describe-Neurodegenerative Diseases', 'Cholesterol-associated-Myotonic Dystrophy', 'Myotonic Dystrophy-associated-Cholesterol', 'Alzheimer Disease-characterized-Gliosis', 'Churg-Strauss Syndrome-be with-Granulomatosis with Polyangiitis', 'Neurodegenerative Diseases-characterized-Gliosis', 'Churg-Strauss Syndrome-confirm-Lymphoproliferative Disorders', 'Granulomatosis with Polyangiitis-confirm-Lymphoproliferative Disorders', 'Mycophenolic Acid-confirm-Lymphoproliferative Disorders', 'Neurogenic Inflammation-induced-HIV Infections', 'Neurogenic Inflammation-lead-Dementia', 'HIV Infections-lead-Dementia', 'Pneumococcal Infections-associated-Renal Insufficiency, Chronic', 'Renal Insufficiency, Chronic-associated-Pneumococcal Infections', 'Polysaccharides-associated-Renal Insufficiency, Chronic', 'Renal Insufficiency, Chronic-associated-Polysaccharides', 'Neurogenic Inflammation-induced-TAT', 'TAT-lead-Dementia', 'GDF15-identify-Idiopathic Pulmonary Fibrosis', 'Glucose Intolerance-known-Diabetes Mellitus', 'INS-improve-Glucose Intolerance', 'Glucose-contribute-Obesity', 'Pain-measured-CRP', 'PRNP-represent-Neurotoxicity Syndromes', 'PRNP-represent-Nerve Degeneration', 'Sarcopenia-associated-GPT', 'GPT-associated-Sarcopenia', 'Glucose Intolerance-predispose-Glucose', 'MALAT1-of targeting be-Lung Neoplasms', 'GDF15-secrete-Adenoma', 'MALAT1-of targeting be-Neoplasms', 'MALAT1-identified-Neoplasms', 'GDF15-secrete-Colorectal Neoplasms', 'GDF15-demonstrate-Colorectal Neoplasms', 'EREG-associate-Inflammation', 'Inflammation-associate-EREG', 'CRP-associated-Vascular Calcification', 'Vascular Calcification-associated-CRP', 'Alzheimer Disease-moderate-Aneurysm', 'APOE-moderate-Aneurysm', 'Sarcoma-driven-rs121913529', 'Hypotension-determine-APOE', 'Inflammation-protect-Infections', 'NLRP3-protect-Inflammation', 'NLRP3-protect-Infections', 'Alzheimer Disease-caused-MAPT', 'Proteostasis Deficiencies-associated-Neurodegenerative Diseases', 'Neurodegenerative Diseases-associated-Proteostasis Deficiencies', 'Neurodegenerative Diseases-associated-TARDBP', 'TARDBP-associated-Neurodegenerative Diseases', 'Epilepsy-sustain-Fractures, Bone', 'Chronic Disease-sustain-Fractures, Bone', 'Valproic Acid-sustain-Fractures, Bone', 'BDNF-evolve-Alzheimer Disease', 'MAPT-identify-Alzheimer Disease', 'KL-correlated-Stroke', 'KL-correlated-Coma', 'KL-correlated-Cerebral Hemorrhage', 'KL-correlated-Hematoma', 'Hyperinsulinism-known-Diabetes Mellitus, Type 2', 'Diabetes Mellitus, Type 2-fight-Alzheimer Disease', 'INS-fight-Alzheimer Disease', 'INS-known-Diabetes Mellitus, Type 2', 'Corneal Dystrophies, Hereditary-result-Cholesterol', 'Genetic Diseases, Inborn-result from-Cholesterol', 'HTT-lead-Nerve Degeneration', 'HTT-lead-Death', 'RB1-associated-Atherosclerosis', 'Atherosclerosis-associated-RB1', 'Inflammation-influence-Wounds and Injuries', 'Inflammation-serve-Multiple Trauma', 'Wounds and Injuries-serve-Multiple Trauma', 'rs2075650-influence-Inflammation', 'rs2075650-influence-Wounds and Injuries', 'rs2075650-serve-Multiple Trauma', 'Metabolic Syndrome-situation with-Obesity, Abdominal', 'INS-result-Metabolic Syndrome', 'INS-result-Obesity, Abdominal', 'INS-result-Fatty Liver', 'Neoplasms-target-CCND1', 'Prostatic Neoplasms-target-CCND1', 'Diabetes Mellitus, Type 2-be traditional predictors for-Cardiovascular Diseases', 'Cardiovascular Diseases-predict-Headache Disorders, Secondary', 'Cholesterol-predict-Cardiovascular Diseases', 'Alzheimer Disease-associated-Parkinsonian Disorders', 'Parkinsonian Disorders-associated-Alzheimer Disease', 'Alzheimer Disease-associated-Myoclonus', 'Myoclonus-associated-Alzheimer Disease', 'Alzheimer Disease-associated-PSEN1', 'PSEN1-associated-Alzheimer Disease', 'Inflammation-predispose-CRP', 'Neurodegenerative Diseases-associated-Neurologic Manifestations', 'Neurologic Manifestations-associated-Neurodegenerative Diseases', 'LMNA-associated-Neurodegenerative Diseases', 'Neurodegenerative Diseases-associated-LMNA', 'LMNA-encode-Neurologic Manifestations', 'HSPA5-o-glcnacylate-Liver Cirrhosis', 'HSPA5-o-glcnacylate-Hepatic Encephalopathy', 'Fractures, Bone-be in-Osteoporosis', 'CTSZ-associated-Fractures, Bone', 'Fractures, Bone-associated-CTSZ', 'CTSZ-associated-Osteoporosis', 'Osteoporosis-associated-CTSZ', 'VEGFA-mediate-Immunologic Deficiency Syndromes', 'Brain Neoplasms-suggest-Melanoma', 'Brain Neoplasms-harbor-rs113488022', 'Melanoma-harbor-rs113488022', 'GPR39-observed-Alzheimer Disease', 'Neurodegenerative Diseases-identify-Dementia', 'GPR39-identify-Dementia', 'Doxorubicin-induce-Breast Neoplasms', 'Doxorubicin-differ-Drug-Related Side Effects and Adverse Reactions', 'CHI3L1-investigated-Alzheimer Disease', 'CHI3L1-investigated-Nervous System Diseases', 'Neoplasms-reduce-Hyperplasia', 'CD4-associated-Pneumonia', 'Pneumonia-associated-CD4', 'Neoplasms-lack-RAB11A', 'RAB11A-reduce-Hyperplasia', 'Meningitis, Bacterial-base-CD4', 'Meningitis, Bacterial-cause-CD4', 'Glucose Metabolism Disorders-reduce-Diabetes Mellitus, Type 2', 'Glucose-improve-Diabetes Mellitus, Type 2', 'KL-reported-Melanoma', 'KL-reported-Mesothelioma', 'KL-reported-Kidney Neoplasms', 'Atrophy-provide-Gliosis', 'TSPO-increased-Atrophy', 'TSPO-provide support as-Gliosis', 'Glucose-lead-Diabetes Mellitus', 'Glucose-lead-Vascular Calcification', 'Glucose-induce-Vascular Calcification', 'Sleep Wake Disorders-serve-Alzheimer Disease', 'Sleep Wake Disorders-delay-Alzheimer Disease', 'MAPT-serve-Sleep Wake Disorders', 'MAPT-delay-Alzheimer Disease', 'Kidney Diseases-be common subtype of-Glomerulonephritis', 'CD79A-be common subtype of-Glomerulonephritis', 'Critical Illness-disengage-Neoplasms', 'Critical Illness-disengage-Heart Arrest', 'Neoplasms-disengage-Heart Arrest', 'Critical Illness-disengage-CDKN2A', 'CDKN2A-disengage-Heart Arrest', 'FNDC5-be in-Bone Neoplasms', 'Hepatolenticular Degeneration-caused-ATP7B', 'Genetic Diseases, Inborn-caused-ATP7B', 'Parkinson Disease-reported-Dyskinesia, Drug-Induced', 'LRRK2-modulate-Parkinson Disease', 'LRRK2-reported-Dyskinesia, Drug-Induced', 'Polycystic Ovary Syndrome-be with-Dyslipidemias', 'Acquired Immunodeficiency Syndrome-suffer-Liver Cirrhosis', 'Alveolitis, Extrinsic Allergic-include-PINK1', 'DNMT3A-associated-Growth Disorders', 'Growth Disorders-associated-DNMT3A', 'DNMT3A-associated-Neoplasms', 'Neoplasms-associated-DNMT3A', 'Lung Diseases, Interstitial-include-PINK1', 'Hypertension-associated-Hyperinsulinism', 'Hyperinsulinism-associated-Hypertension', 'Polycystic Ovary Syndrome-associated-Hyperinsulinism', 'Hyperinsulinism-associated-Polycystic Ovary Syndrome', 'Polycystic Ovary Syndrome-associated-INS', 'INS-associated-Polycystic Ovary Syndrome', 'Hypertension-affect-Metabolic Syndrome', 'Obesity-affect-Metabolic Syndrome', 'INS-affect-Metabolic Syndrome', 'Obesity-considered-Polycystic Ovary Syndrome', 'INS-considered-Polycystic Ovary Syndrome', 'Heart Failure-found-MME', 'Death-found-MME', 'Wounds and Injuries-up-regulate-FKBP5', 'Non-alcoholic Fatty Liver Disease-seen-Metabolic Diseases', 'Non-alcoholic Fatty Liver Disease-seen-Obesity', 'Non-alcoholic Fatty Liver Disease-seen-Sarcopenia', 'Metabolic Diseases-associated-Sarcopenia', 'Sarcopenia-associated-Metabolic Diseases', 'Non-alcoholic Fatty Liver Disease-seen-INS', 'Choroiditis-be with-Retinal Detachment', 'Choroiditis-seen-Ipilimumab', 'Parkinson Disease, Secondary-include-Nervous System Diseases', 'Brain Injuries, Traumatic-include-Nervous System Diseases', 'Eosinophilia-demonstrate-COL17A1', 'Retinal Detachment-demonstrate-COL17A1', 'Hypoxia-reduce-Hypertension', 'Hypoxia-reduce-KL', 'MAPT-aggregated-Nervous System Diseases', 'MAPT-aggregated-Parkinson Disease', 'MAPT-hyperphosphorylate-Parkinson Disease, Secondary', 'Diabetes Mellitus, Type 2-share-Alzheimer Disease', 'MAPT-aggregated-Alzheimer Disease', 'Diabetes Mellitus, Type 2-share-Hyperglycemia', 'MAPT-aggregated-Brain Injuries, Traumatic', 'Diabetes Mellitus, Type 2-share-Hyperinsulinism', 'Diabetes Mellitus, Type 2-share-Dyslipidemias', 'Diabetes Mellitus, Type 2-share-Inflammation', 'Diabetes Mellitus, Type 2-share-INS', 'Diabetes Mellitus, Type 2-share-Glucose', 'Dementia-characterized-Atrophy', 'Dementia-characterized-Memory Disorders', 'Diabetes Mellitus-diagnose-Hypertension', 'FGF23-lead to-Fibrosis', 'FGF23-lead to-Idiopathic Pulmonary Fibrosis', 'Dementia, Vascular-increased-Alzheimer Disease', 'Neoplasms-be with-Leukopenia', 'Neoplasms-treat-Leukopenia', 'Polysaccharides-treat-Neoplasms', 'Polysaccharides-treat-Leukopenia', 'Hypertension-associated-rs7895833', 'rs7895833-associated-Hypertension', 'Neuralgia-remain-Diabetes Mellitus', 'Neuralgia-remain-CD4', 'Fibrosis-base-GPT', 'Hypotension-associate-Inflammation', 'Inflammation-associate-Hypotension', 'Pneumonia-treated-Bacterial Infections', 'CRP-remain-Pneumonia', 'CRP-treated-Bacterial Infections', 'Fibrosis-be severe in-Spinal Stenosis', 'ELN-be severe in-Spinal Stenosis', 'ACE-process of-Neurodegenerative Diseases', 'ACE-counteract-Neurodegenerative Diseases', 'ACE-counteract-Dementia', 'CD4-isolated-Arthritis, Rheumatoid', 'Triglycerides-associated-Sarcopenia', 'Sarcopenia-associated-Triglycerides', 'CD4-isolated-Lupus Erythematosus, Systemic', 'rs121913483-compare-FGFR3', 'CD4-isolated-Multiple Sclerosis', 'Amyloidosis-manifested-Amyloid Neuropathies, Familial', 'CD4-isolated-Inflammation', 'Amyloidosis-manifested-Cardiomyopathies', 'Neoplasms-be with-FGFR3', 'TTR-manifested-Amyloidosis', 'rs121913483-compare-Neoplasms', 'GPT-reviewed-End Stage Liver Disease', 'GPT-used-Fibrosis', 'GPT-evaluate-Fibrosis', 'CLU-involved-Inflammation', 'CLU-involved-Death', 'CLU-involved-Neoplastic Syndromes, Hereditary', 'CLU-involved-Alzheimer Disease', 'Osteoporosis-compare-Osteoarthritis', 'CLU-be in-Osteoporosis', 'CLU-compare-Osteoarthritis', 'CLU-propose-Muscular Diseases', 'Tuberculosis-treated-Hearing Loss', 'Tuberculosis-experience-Hearing Loss', 'Tuberculosis-treated-Aminoglycosides', 'Aminoglycosides-experience-Hearing Loss', 'Aminoglycosides-treated-Tuberculosis', 'Rheumatic Diseases-optimized-Cardiovascular Diseases', 'Arthritis, Rheumatoid-optimized-Cardiovascular Diseases', 'Arthritis, Rheumatoid-monitor-Glucose', 'Arthritis, Rheumatoid-used-TNF', 'Cachexia-characterized-Inflammation', 'Proteinuria-associated-Metabolic Syndrome', 'Metabolic Syndrome-associated-Proteinuria', 'Proteinuria-associated-KL', 'KL-associated-Proteinuria', 'Sleep Deprivation-contribute-FGF21', 'Cachexia-contribute-FGF21', 'Death-subdivided-Critical Illness', 'MIR155-indicate-Death', 'MIR155-subdivided-Critical Illness', 'Metabolic Diseases-linked-Hyperinsulinism', 'Metabolic Diseases-linked-Diabetes Mellitus', 'Metabolic Diseases-linked-Liver Diseases', 'Metabolic Diseases-linked-Neoplasms', 'Metabolic Diseases-linked-Neurodegenerative Diseases', 'Metabolic Diseases-linked-Heart Diseases', 'Metabolic Diseases-linked-Infections', 'Hyperinsulinism-to susceptibility be-Liver Diseases', 'Metabolic Diseases-implicated-SIRT4', 'SIRT4-implicated-Hyperinsulinism', 'SIRT4-implicated-Diabetes Mellitus', 'SIRT4-implicated-Liver Diseases', 'SIRT4-linked-Liver Diseases', 'SIRT4-implicated-Neoplasms', 'SIRT4-implicated-Neurodegenerative Diseases', 'SIRT4-implicated-Heart Diseases', 'SIRT4-linked-Heart Diseases', 'SIRT4-implicated-Infections', 'UMOD-linked-Death', 'UMOD-linked-Cardiovascular Diseases', 'Alcoholism-distinguish-Alzheimer Disease', 'Alcoholism-distinguish-Wounds and Injuries', 'Glucose-include-Myotonic Dystrophy', 'Glucose-include-Diabetes Mellitus, Type 2', 'Neurodegenerative Diseases-include-Muscular Dystrophies', 'Polysaccharides-used-Diabetes Mellitus', 'Neurodegenerative Diseases-include-Lipodystrophy', 'Polysaccharides-used-Neoplasms', 'Neurodegenerative Diseases-include-Progeria', 'Renal Insufficiency, Chronic-base-Death', 'Renal Insufficiency, Chronic-use-Death', 'Renal Insufficiency, Chronic-investigate-CST3', 'Renal Insufficiency, Chronic-base-CST3', 'LMNA-associated-Muscular Dystrophies', 'Muscular Dystrophies-associated-LMNA', 'LMNA-include-Lipodystrophy', 'LMNA-associated-Nervous System Diseases', 'Nervous System Diseases-associated-LMNA', 'LMNA-include-Nervous System Diseases', 'LMNA-include-Progeria', 'Dementia-occur-Cerebrovascular Disorders', 'APOE-implicate-Alzheimer Disease', 'APOE-implicate-Cardiovascular Diseases', 'Obesity, Abdominal-be significant contributors to-Heart Failure, Diastolic', 'Hypertension-be significant contributors to-Heart Failure, Diastolic', 'Glucose-be significant contributors to-Heart Failure, Diastolic', 'Diabetes Mellitus-be with-Atrial Fibrillation', 'Diabetes Mellitus-type-Atrial Fibrillation', 'Delirium-predict-Critical Illness', 'S100A1-predict-Delirium', 'S100A1-predict-Critical Illness', 'Heart Arrest-reverse-Pulmonary Disease, Chronic Obstructive', 'Neurotoxicity Syndromes-attenuate-Inflammation', 'Death-include-Proteinuria', 'Death-include-PTH', 'FGF23-associated-Alzheimer Disease', 'Alzheimer Disease-associated-FGF23', 'Neurotoxicity Syndromes-be in-Parkinson Disease', 'Neurotoxicity Syndromes-exert-Parkinson Disease', 'Neurotoxicity Syndromes-target-STAT1', 'Parkinson Disease-target-STAT1', 'Death, Sudden, Cardiac-include-Death', 'Lipofuscin-observed-Death', 'Lipofuscin-observed-Death, Sudden, Cardiac', 'Valproic Acid-include-Seizures', 'MAPT-processed-Diabetes Mellitus', 'MAPT-play-Diabetes Mellitus', 'KL-contribute-Vascular Calcification', 'KL-protect-Vascular Calcification', 'HIV Infections-contributing-AIDS Arteritis, Central Nervous System', 'HIV Infections-include-AIDS Arteritis, Central Nervous System', 'AIDS Arteritis, Central Nervous System-include-Proteostasis Deficiencies', 'AIDS Arteritis, Central Nervous System-contributing-Proteostasis Deficiencies', 'AIDS Arteritis, Central Nervous System-include-Inflammation', 'AIDS Arteritis, Central Nervous System-contributing-Inflammation', 'TARDBP-associated-Nervous System Diseases', 'Nervous System Diseases-associated-TARDBP', 'Neurodegenerative Diseases-include-AIDS Arteritis, Central Nervous System', 'Kidney Diseases-mitigate-Proteinuria', 'Kidney Diseases-mitigate-Glomerulonephritis', 'Alzheimer Disease-include-AIDS Arteritis, Central Nervous System', 'Kidney Diseases-mitigate-Valproic Acid', 'Valproic Acid-mitigate-Proteinuria', 'Valproic Acid-mitigate-Glomerulonephritis', 'Cardiac Output, Low-bother-Hepatitis C', 'Cardiac Output, Low-bother-Kidney Diseases', 'Cardiac Output, Low-bother-Anemia', 'Sleep Initiation and Maintenance Disorders-bother-Hepatitis C', 'Sleep Initiation and Maintenance Disorders-bother-Kidney Diseases', 'Sleep Initiation and Maintenance Disorders-bother-Anemia', 'Cardiac Output, Low-bother-CD4', 'Sleep Initiation and Maintenance Disorders-bother-CD4', 'Genetic Diseases, Inborn-caused-DMD', 'Aneurysm-include-Diabetes Mellitus', 'Parkinson Disease-delay-Death', 'Alzheimer Disease-delay-Death', 'Heart Diseases-take-INS', 'SNCA-delay-Death', 'Renal Insufficiency, Chronic-take-INS', 'Hypoglycemia-take-INS', 'Diabetes Mellitus-involve-Microvascular Angina', 'Diabetes Mellitus-involve-Inflammation', 'Genetic Diseases, Inborn-characterized-Abnormalities, Drug-Induced', 'RECQL4-suffer-Genetic Diseases, Inborn', 'CBX8-regulate-Neoplasms', 'RECQL4-suffer-Abnormalities, Drug-Induced', 'RECQL4-suffer-Neoplasms', 'GBA-linked-Parkinson Disease', 'GBA-linked-Dementia', 'Hypertriglyceridemia-reconstitute-Immunologic Deficiency Syndromes', 'INS-lead-Chronic Disease', 'INS-lead-Fibrosis', 'Diabetes Mellitus, Type 2-develop-Alzheimer Disease', 'Diabetes Mellitus, Type 2-pose-AKT1', 'Alzheimer Disease-pose-AKT1', 'KL-considered-Cardiovascular Diseases', 'KL-considered-Heart Injuries', 'Lymphoma-associated-Leukoencephalopathy, Progressive Multifocal', 'Leukoencephalopathy, Progressive Multifocal-associated-Lymphoma', 'Lymphoma-treat-Leukoencephalopathy, Progressive Multifocal', 'Lymphoma-treat-Arbovirus Infections', 'Rituximab-treat-Lymphoma', 'Rituximab-associated-Leukoencephalopathy, Progressive Multifocal', 'Leukoencephalopathy, Progressive Multifocal-associated-Rituximab', 'Rituximab-associated-Arbovirus Infections', 'Arbovirus Infections-associated-Rituximab', 'CP-play-Alzheimer Disease', 'ITGB4-involved-Asthma', 'CP-play-Neurodegenerative Diseases', 'Sugars-pose-Hypertension', 'Cholesterol-pose-Hypertension', 'Diabetes Mellitus-be with-Coronary Artery Disease', 'MAPT-discriminate-Alzheimer Disease', 'rs1207568-related-Cardiovascular Diseases', 'KL-associated-Urolithiasis', 'Urolithiasis-associated-KL', 'rs1207568-associated-Urolithiasis', 'Urolithiasis-associated-rs1207568', 'rs1207568-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-rs1207568', 'Alzheimer Disease-followed-MAPT', 'Vascular System Injuries-attenuate-Diabetes Mellitus', 'SERPINA4-attenuate-Vascular System Injuries', 'SERPINA4-attenuate-Diabetes Mellitus', 'SERPINA4-exacerbate-Aortic Diseases', 'SERPINA4-exacerbate-Diabetes Mellitus', 'SERPINA4-novel role in-Vascular System Injuries', 'SERPINA4-display-Vascular System Injuries', 'SERPINA4-inhibit-Inflammation', 'APOE-examine-Stroke', 'AIF1-linked-Obesity', 'AIF1-linked-Liver Diseases', 'Alzheimer Disease-recapitulate-MAPT', 'Dementia-recapitulate-MAPT', 'ACE-tested-Hypertension', 'ACE-tested-Stroke', 'Hypertension-analyzed-Stroke', 'rs650439-associated-KL', 'KL-associated-rs650439', 'Hypertension-analyzed-rs650439', 'KL-associated-Stroke', 'Stroke-associated-KL', 'Hypertension-higher incidence of-Stroke', 'rs650439-associated-Stroke', 'Stroke-associated-rs650439', 'rs650439-associated-Hypertension', 'Hypertension-associated-rs650439', 'Hypertension-be with-rs650439', 'KL-correlated-Hypertension', 'INS-increase in-Immunologic Deficiency Syndromes', 'INS-increase-Adrenal Insufficiency', 'Alzheimer Disease-associated-Hypothalamic Diseases', 'Hypothalamic Diseases-associated-Alzheimer Disease', 'LEP-increase in-Alzheimer Disease', 'LEP-associated-Hypothalamic Diseases', 'Hypothalamic Diseases-associated-LEP', 'Alzheimer Disease-underlie-Memory Disorders', 'FMR1-associated-Aging, Premature', 'Aging, Premature-associated-FMR1', 'Nerve Degeneration-underlie-Memory Disorders', 'FMR1-associated-Infertility, Female', 'Infertility, Female-associated-FMR1', 'Ovarian Diseases-be in-Infertility, Female', 'INSR-underlie-Memory Disorders', 'FMR1-result-Ovarian Diseases', 'FMR1-result-Infertility, Female', 'Huntington Disease-caused-HTT', 'MAPT-implicated-Huntington Disease', 'Genetic Diseases, Inborn-caused-HTT', 'GAS6-be discriminatory for-Venous Thromboembolism', 'GAS6-be discriminatory for-Hemorrhage', 'GAS6-associated-Venous Thromboembolism', 'Venous Thromboembolism-associated-GAS6', 'GAS6-associated-Hemorrhage', 'Hemorrhage-associated-GAS6', 'GAS6-associated-Death', 'Death-associated-GAS6', 'Plaque, Amyloid-obtain-Death', 'Plaque, Amyloid-obtain-Gastrointestinal Hemorrhage', 'GAS6-associate-Venous Thromboembolism', 'Venous Thromboembolism-associate-GAS6', 'GAS6-associate-Hemorrhage', 'Hemorrhage-associate-GAS6', 'GAS6-associate-Death', 'Death-associate-GAS6', 'Coronary Artery Disease-combined-Hypertension', 'KL-combined-Hypertension', 'KL-play-Coronary Artery Disease', 'RORA-associated-Asthma', 'Asthma-associated-RORA', 'GDF11-treat-Heart Diseases', 'RORA-associated-Drug Hypersensitivity', 'Drug Hypersensitivity-associated-RORA', 'Neoplasms-show-Ovarian Neoplasms', 'CERS2-related-Neoplasms', 'CERS2-show-Neoplasms', 'CERS2-show-Ovarian Neoplasms', 'Diabetes Mellitus-measured-Glucose Intolerance', 'Glucose-measured-Glucose Intolerance', 'Diabetes Mellitus-predict-Cardiovascular Diseases', 'Diabetes Mellitus-predict-Cholesterol', 'Cardiovascular Diseases-predict-Cholesterol', 'Cardiovascular Diseases-present-Cholesterol', 'MTOR-revisit-Diabetic Nephropathies', 'Anemia, Aplastic-carry-PIGA', 'PIGA-manifested-Hemoglobinuria, Paroxysmal', 'Neurodegenerative Diseases-caused-HTT', 'Kidney Diseases-be common type of-Glomerulonephritis', 'CD79A-be common type of-Glomerulonephritis', 'Alzheimer Disease-place-Hyperkinesis', 'Hyperkinesis-place-Alzheimer Disease', 'Alzheimer Disease-place-MAPT', 'Hyperkinesis-place-MAPT', 'Hyperkinesis-facilitate-Alzheimer Disease', 'Hyperkinesis-facilitate-MAPT', 'EWSR1-associated-Central Nervous System Diseases', 'Central Nervous System Diseases-associated-EWSR1', 'EWSR1-associated-Amyotrophic Lateral Sclerosis', 'Amyotrophic Lateral Sclerosis-associated-EWSR1', 'EWSR1-associated-Dementia', 'Dementia-associated-EWSR1', 'TOMM40-associated-Parkinson Disease', 'Parkinson Disease-associated-TOMM40', 'TOMM40-associated-Dementia', 'Dementia-associated-TOMM40', 'Death-cause-Extranodal Extension', 'Death-cause-Blindness', 'Extranodal Extension-include-Blindness', 'Extranodal Extension-cause-Blindness', 'Cholesterol-include-Extranodal Extension', 'Hyperglycemia-associated-Glucose', 'Glucose-associated-Hyperglycemia', 'Muscular Atrophy-related-Diabetes Mellitus', 'Glucose-medications on-Diabetes Mellitus', 'Glucose-lowering-Diabetes Mellitus', 'Glucose-medications on-Muscular Atrophy', 'Glucose-lowering-Muscular Atrophy', 'Hypothermia-implicate-Alzheimer Disease', 'Hypothermia-implicate-MAPT', 'Dementia-used-Gout', 'Dementia-assess-Gout', 'Heart Diseases-used-Gout', 'Gout-used-ACE', 'Dementia-used-ACE', 'Heart Diseases-used-ACE', 'SENP2-act-Leukemia, Lymphocytic, Chronic, B-Cell', 'SIRT1-emerge-Diabetes Mellitus, Type 2', 'SIRT1-emerge-Cardiovascular Diseases', 'SIRT1-emerge-Neoplasms', 'Neoplasms-result-Obesity', 'Obesity-result-Parkinson Disease', 'Neoplasms-driven-LEP', 'Obesity-driven-LEP', 'Parkinson Disease-driven-LEP', 'Inflammation-follow-Coronary Artery Disease', 'Coronary Artery Disease-increase-Stroke', 'WNT1-associated-Osteogenesis Imperfecta', 'Osteogenesis Imperfecta-associated-WNT1', 'WNT1-associated-Osteoporosis', 'Osteoporosis-associated-WNT1', 'Skin Neoplasms-enhance-Melanoma', 'AR-enhance-Skin Neoplasms', 'AR-enhance-Melanoma', 'AR-overcome-Vision Disorders', 'TMEM106B-associated-Chronic Traumatic Encephalopathy', 'Chronic Traumatic Encephalopathy-associated-TMEM106B', 'AR-underlie-Skin Neoplasms', 'AR-underlie-Dysplastic Nevus Syndrome', 'Chronic Traumatic Encephalopathy-genotyped-rs3173615', 'Neurodegenerative Diseases-genotyped-rs3173615', 'Inflammation-indexed-CRP', 'STAT3-predict-Neoplasms', 'STAT3-predict-Urinary Bladder Neoplasms', 'Atrial Fibrillation-associate-Arrhythmias, Cardiac', 'Arrhythmias, Cardiac-associate-Atrial Fibrillation', 'Atrial Fibrillation-associate-FAS-AS1', 'FAS-AS1-associate-Atrial Fibrillation', 'Atrial Fibrillation-associated-FAS-AS1', 'FAS-AS1-associated-Atrial Fibrillation', 'Heart Failure-associated-FAS-AS1', 'FAS-AS1-associated-Heart Failure', 'Heart Failure-disease of-Obesity', 'IGFBP7-related-Heart Failure', 'IGFBP7-related-Obesity', 'Inflammation-contribute-Metabolic Syndrome', 'CRP-contribute-Metabolic Syndrome', 'Heart Failure-characterized-Fibrosis', 'Immunologic Deficiency Syndromes-lead-Demyelinating Diseases', 'Immunologic Deficiency Syndromes-lead-Dementia', 'RETN-secreted-Obesity', 'Glutathione-observed-Tuberculosis', 'Glutathione-observed-HIV Infections', 'Glutathione-observed-Diabetes Mellitus', 'Glutathione-observed-Neoplasms', 'Diabetes Mellitus, Type 2-link-Alzheimer Disease', 'RETN-derived-Obesity', 'Metabolic Syndrome-defined-Hyperinsulinism', 'Metabolic Syndrome-include-Hyperinsulinism', 'RETN-alter-Metabolic Diseases', 'RETN-derived-Metabolic Diseases', 'Metabolic Syndrome-defined-Glucose Intolerance', 'Metabolic Syndrome-include-Glucose Intolerance', 'Metabolic Syndrome-include-Diabetes Mellitus', 'Metabolic Syndrome-defined-Obesity, Abdominal', 'Metabolic Syndrome-defined-INS', 'PLIN2-involved-Fatty Liver', 'PLIN2-involved-Diabetes Mellitus, Type 2', 'Obesity-termed-Metabolic Syndrome', 'Metabolic Syndrome-termed-Death', 'Metabolic Syndrome-termed-Diabetes Mellitus', 'INS-elevate-Triglycerides', 'INS-termed-Metabolic Syndrome', 'Obesity-elevate-Triglycerides', 'Triglycerides-termed-Metabolic Syndrome', 'rs1815739-suggest-Muscular Diseases', 'rs1815739-suggest-Glycogen Storage Disease Type V', 'rs1815739-suggest-Muscular Dystrophy, Duchenne', 'LEP-associate-Headache Disorders, Secondary', 'Headache Disorders, Secondary-associate-LEP', 'Lymphoma-driven-MLH1', 'MAPT-lead-Dementia', 'Colorectal Neoplasms-used-Neoplasms', 'MUC1-overexpressed-Neoplasms', 'MUC1-overexpressed-Colorectal Neoplasms', 'MUC1-used-Neoplasms', 'Neoplasms-be in-Colorectal Neoplasms', 'Hypertrophy, Left Ventricular-be in-Hypertension', 'Cardiovascular Diseases-assigned-Myocardial Infarction', 'Cardiovascular Diseases-assigned-Stroke', 'Kidney Diseases-predict-Carcinoma, Hepatocellular', 'Cardiovascular Diseases-assigned-INS', 'Cardiovascular Diseases-assigned-Insulin Glargine', 'Nerve Degeneration-reflect-Alzheimer Disease', 'MARCKS-reflect-Nerve Degeneration', 'Alzheimer Disease-reflect-MARCKS', 'von Willebrand Diseases-include-Hemorrhage', 'Ghrelin-reduce-Nervous System Diseases', 'Ghrelin-reduce-Fibrosis', 'von Willebrand Diseases-include-VWF', 'Diabetes Mellitus-provided-Glucose', 'PCSK9-decreased-Aortic Aneurysm, Abdominal', 'Renal Insufficiency, Chronic-provided-Glucose', 'FBL-reduce-Inflammation', 'ABCA1-lead-Hearing Loss, Central', 'ABCA1-lead-White Dot Syndromes', 'Cholesterol-lead-Hearing Loss, Central', 'Cholesterol-lead-White Dot Syndromes', 'Metabolic Syndrome-associated-Diabetes Mellitus, Type 2', 'Diabetes Mellitus, Type 2-associated-Metabolic Syndrome', 'Neoplasms-engage-Cachexia', 'Neoplasms-engage-Anorexia', 'Hypertension-comprise-Metabolic Syndrome', 'Anorexia-engage-Cachexia', 'Cachexia-engage-Neoplasms', 'Anorexia-associated-Neoplasms', 'Neoplasms-associated-Anorexia', 'Breast Neoplasms-scheduled-Anthracyclines', 'Breast Neoplasms-assigned-Anthracyclines', 'Breast Neoplasms-receive-Anthracyclines', 'Neoplasms-scheduled-Anthracyclines', 'Neoplasms-assigned-Anthracyclines', 'Neoplasms-receive-Anthracyclines', 'TAT-induce-Mitochondrial Diseases', 'TAT-cause-Nerve Degeneration', 'Giant Cell Arteritis-present-Inflammation', 'Cataract-linked-Hypoalphalipoproteinemias', 'Diabetes Mellitus-linked-Hypoalphalipoproteinemias', 'Glaucoma-linked-Hypoalphalipoproteinemias', 'Death-reflected-Sphingolipidoses', 'Death-reflected-Sphingolipids', 'Sphingolipids-reflected-Sphingolipidoses', 'Blood Glucose-linked-Cataract', 'Blood Glucose-linked-Parkinson Disease', 'Blood Glucose-linked-Alzheimer Disease', 'Blood Glucose-linked-Diabetes Mellitus', 'Glaucoma-linked-Blood Glucose', 'APOE-link-Brain Diseases', 'APOE-link-Alzheimer Disease', 'Muscle Weakness-followed-Atrophy', 'SIRT3-play-Ventricular Remodeling', 'MSTN-associated-Muscle Weakness', 'Muscle Weakness-associated-MSTN', 'Cardiomegaly-associated-Heart Failure', 'Heart Failure-associated-Cardiomegaly', 'MSTN-associated-Atrophy', 'Atrophy-associated-MSTN', 'MSTN-induced-Atrophy', 'SIRT3-play-Heart Failure', 'SIRT3-protect-Cardiomegaly', 'SIRT3-protect-Heart Diseases', 'Heart Diseases-characterize-Arrhythmias, Cardiac', 'SIRT3-associated-Heart Failure', 'Heart Failure-associated-SIRT3', 'Heart Diseases-characterize-Ventricular Dysfunction', 'Arrhythmias, Cardiac-referred-Heart Failure', 'Ventricular Dysfunction-referred-Heart Failure', 'LMNA-associated-Heart Diseases', 'Heart Diseases-associated-LMNA', 'LMNA-characterize-Arrhythmias, Cardiac', 'LMNA-characterize-Ventricular Dysfunction', 'LMNA-associated-Heart Failure', 'Heart Failure-associated-LMNA', 'Supranuclear Palsy, Progressive-include-Neurodegenerative Diseases', 'Brain Injuries, Traumatic-include-Neurodegenerative Diseases', 'AR-enable-Drug Hypersensitivity', 'MAPT-be common pathology among-Neurodegenerative Diseases', 'Idiopathic Pulmonary Fibrosis-mitigate-Pulmonary Fibrosis', 'Pulmonary Fibrosis-attenuate-Weight Loss', 'Cardiomyopathy, Dilated-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-Cardiomyopathy, Dilated', 'MAPK1-treated-Ventricular Fibrillation', 'Tauopathies-target-Neurodegenerative Diseases', 'Alzheimer Disease-target-Neurodegenerative Diseases', 'EZR-target-Neurodegenerative Diseases', 'Glucose Metabolism Disorders-altered-Alzheimer Disease', 'INS-altered-Alzheimer Disease', 'Sarcopenia-result-Mitochondrial Diseases', 'Sarcopenia-include-Mitochondrial Diseases', 'Sarcopenia-result-Inflammation', 'Glucose Metabolism Disorders-modulate-Diabetes Mellitus', 'Sarcopenia-result-INS', 'Myelodysplastic Syndromes-require-Neoplasms', 'MYBL2-require-Neoplasms', 'Infections-considered-Alzheimer Disease', 'Infections-induce-Alzheimer Disease', 'Infections-considered-IL17A', 'Aneurysm-associated-Triglycerides', 'Triglycerides-associated-Aneurysm', 'Sphingolipids-associated-Inflammation', 'Inflammation-associated-Sphingolipids', 'Sphingolipids-associated-Neurodegenerative Diseases', 'Neurodegenerative Diseases-associated-Sphingolipids', 'Alzheimer Disease-involved-APOE', 'NRGN-seem-Alzheimer Disease', 'Mitochondrial Diseases-include-Parkinson Disease', 'FGF21-increased-Obesity', 'FGF21-increased-Diabetes Mellitus', 'FGF21-correlated-Glucose Intolerance', 'ALDH2-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-ALDH2', 'ALDH2-involved-Cardiovascular Diseases', 'ALDH2-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-ALDH2', 'ALDH2-involved-Diabetes Mellitus', 'Ataxia-associated-Non-alcoholic Fatty Liver Disease', 'Non-alcoholic Fatty Liver Disease-associated-Ataxia', 'ALDH2-associated-Neurodegenerative Diseases', 'Neurodegenerative Diseases-associated-ALDH2', 'ALDH2-involved-Neurodegenerative Diseases', 'Alzheimer Disease-interact-Glucose Metabolism Disorders', 'PRKAA2-treat-Bone Diseases, Metabolic', 'PRKAA2-treat-Osteoporosis', 'MAPT-interact-Glucose Metabolism Disorders', 'Aortic Valve Stenosis-associated-Angiodysplasia', 'Angiodysplasia-associated-Aortic Valve Stenosis', 'Hemorrhage-associated-Angiodysplasia', 'Angiodysplasia-associated-Hemorrhage', 'VWF-be strongest link between-Aortic Valve Stenosis', 'VWF-associated-Angiodysplasia', 'Angiodysplasia-associated-VWF', 'Nerve Degeneration-recapitulate-Brain Diseases', 'NRXN3-associated-Alzheimer Disease', 'Alzheimer Disease-associated-NRXN3', 'TH-thought-Neurodegenerative Diseases', 'Death-affect-Inflammation', 'Death-affect-Obesity', 'LEP-affect-Death', 'LEP-affect-Inflammation', 'LEP-be related to-Death', 'LEP-be related to-Neoplasms', 'LEP-increase-Neoplasms', 'LEP-related-Death', 'LEP-related-Neoplasms', 'Parkinson Disease, Secondary-associate with-Neurodegenerative Diseases', 'MAPT-associate-Neurodegenerative Diseases', 'Neurodegenerative Diseases-associate-MAPT', 'MAPT-associate-Alzheimer Disease', 'Alzheimer Disease-associate-MAPT', 'MAPT-associate-Parkinson Disease, Secondary', 'Parkinson Disease, Secondary-associate-MAPT', 'APOE-implicated-AIDS Arteritis, Central Nervous System', 'Amyotrophic Lateral Sclerosis-include-Chronic Disease', 'NFE2L2-linked-Chronic Disease', 'NFE2L2-linked-Parkinson Disease', 'Nerve Degeneration-related-Alzheimer Disease', 'APOE-assessed-Brain Injuries, Traumatic', 'NFE2L2-linked-Alzheimer Disease', 'KL-avoid-Nerve Degeneration', 'NFE2L2-linked-Amyotrophic Lateral Sclerosis', 'KL-play-Alzheimer Disease', 'INS-include-Chronic Disease', 'SIRT6-known-Diabetes Mellitus', 'SIRT6-known-Neoplasms', 'Aneurysm-associated-Obesity', 'Obesity-associated-Aneurysm', 'SIRT6-ascertained-Neurodegenerative Diseases', 'Diabetes Mellitus-involved-Liver Diseases', 'SIRT6-known-Heart Diseases', 'SIRT6-understand-Heart Diseases', 'Obesity-associated-Hyperglycemia', 'Hyperglycemia-associated-Obesity', 'Obesity-associated-Cardiomyopathies', 'Cardiomyopathies-associated-Obesity', 'SIRT6-have show-Liver Diseases', 'SIRT6-involved-Liver Diseases', 'SIRT6-understand-Liver Diseases', 'SIRT6-understand-Inflammation', 'NR3C2-prevent-Aneurysm', 'Sugars-associated-Hyperglycemia', 'Hyperglycemia-associated-Sugars', 'NR3C2-demonstrate-Obesity', 'NR3C2-prevent-Acute Kidney Injury', 'Sugars-associated-Cardiomyopathies', 'Cardiomyopathies-associated-Sugars', 'Cholesterol-reduce-Death', 'NR3C2-prevent-Adenocarcinoma', 'Cholesterol-reduce-Ischemia', 'NR3C2-prevent-Reperfusion Injury', 'KL-identified-Lung Neoplasms', 'Kidney Diseases-associated-Femoral Neck Fractures', 'Femoral Neck Fractures-associated-Kidney Diseases', 'Kidney Diseases-associated-PTH', 'PTH-associated-Kidney Diseases', 'Diabetes Mellitus-use-HIV Infections', 'Diabetes Mellitus-use-Glucose', 'Alzheimer Disease-manifested-MAPT', 'VEGFA-altered-Alzheimer Disease', 'VEGFA-altered-Dementia, Vascular', 'FANCC-underlie-Neoplasms', 'FANCC-underlie-Inflammation', 'FANCC-underlie-Diabetes Mellitus', 'HIV Infections-linked-Dyslipidemias', 'HIV Infections-linked-Osteoporosis', 'HIV Infections-linked-INS', 'Renal Insufficiency, Chronic-assessed-Hypertension', 'Renal Insufficiency, Chronic-assessed-Obesity', 'Renal Insufficiency, Chronic-assessed-Obesity, Abdominal', 'Renal Insufficiency, Chronic-assessed-Diabetes Mellitus', 'Renal Insufficiency, Chronic-assessed-Cholesterol', 'Parkinson Disease-diagnosed-Metabolic Syndrome', 'Parkinson Disease-diagnosed-Cholesterol', 'MAPT-associated-Glucose Metabolism Disorders', 'Glucose Metabolism Disorders-associated-MAPT', 'PLXNB1-mediated-Alzheimer Disease', 'Viremia-restore-CD4', 'HIV Infections-identify-CD4', 'MAPT-observed-Cerebral Small Vessel Diseases', 'Alzheimer Disease-decrease-Glucose', 'Diabetes Mellitus, Type 2-decrease-Glucose', 'Diabetes Mellitus-confer-Optic Neuropathy, Ischemic', 'Hypertension-confer-Optic Neuropathy, Ischemic', 'Diabetes Mellitus-confer-ATOH7', 'Hypertension-confer-ATOH7', 'ATOH7-increase risk of-Optic Neuropathy, Ischemic', 'ATOH7-confer-Optic Neuropathy, Ischemic', 'Diabetes Mellitus-develop-Coma', 'Diabetes Mellitus-develop-INS', 'Coma-develop-INS', 'Coma-be in-Diabetes Mellitus', 'Coma-be in-INS', 'Coma-prevent-Diabetes Mellitus', 'INS-prevent-Coma', 'Alzheimer Disease-comprise-MAPT', 'Neurodegenerative Diseases-comprise of-MAPT', 'Hereditary Breast and Ovarian Cancer Syndrome-related-BRCA2', 'Inflammation-lead-Cardiovascular Diseases', 'Inflammation-lead-Cholesterol', 'Cholesterol-show associations with-Mesenteric Vascular Occlusion', 'Cholesterol-show associations with-Death', 'Neurodegenerative Diseases-reduce-IGF1', 'Cholesterol-show-Diabetes Mellitus', 'Cholesterol-associations to-Mesenteric Vascular Occlusion', 'Cholesterol-associations to-Death', 'Alzheimer Disease-reduce-IGF1', 'Congenital Hyperinsulinism-measure-Obesity', 'Diabetes Mellitus-worsened-Glucose Metabolism Disorders', 'Congenital Hyperinsulinism-measure-Diabetes Mellitus', 'Diabetes Mellitus-worsened-INS', 'INS-worsened-Glucose Metabolism Disorders', 'Congenital Hyperinsulinism-measure-INS', 'Congenital Hyperinsulinism-measure-Glucose', 'Glucose-measure-Obesity', 'Glucose-measure-Diabetes Mellitus', 'Pulmonary Disease, Chronic Obstructive-upregulate-PGF', 'PGF-promote-Emphysema', 'Diabetes Mellitus-infer-INS', 'INS-infer-Obesity', 'INS-infer-Diabetes Mellitus, Type 2', 'NLRP3-regulate-Inflammation', 'NLRP3-associated-Chronic Disease', 'Chronic Disease-associated-NLRP3', 'Inflammation-observed-Alzheimer Disease', 'MAPT-observed-Alzheimer Disease', 'Cerebral Infarction-distinguish-Cerebral Arterial Diseases', 'Polysaccharides-distinguish-Cerebral Arterial Diseases', 'Hyperplasia-driven-Inflammation', 'Inflammation-driven-Asthma', 'H19-driven-Inflammation', 'Metabolic Diseases-induced-Fructose', 'Metabolic Syndrome-include-Fatty Liver', 'Fructose-induce-Metabolic Syndrome', 'Fructose-include-Fatty Liver', 'FAR2-associated-Diabetic Nephropathies', 'Diabetic Nephropathies-associated-FAR2', 'FAR2-associated-Lupus Nephritis', 'Lupus Nephritis-associated-FAR2', 'FAR2-associated-Kidney Diseases', 'Kidney Diseases-associated-FAR2', 'NEFL-reflected-Basal Ganglia Diseases', 'Muscular Dystrophies-include-LMNA', 'NEFL-reflected-Alzheimer Disease', 'Peripheral Nervous System Diseases-include-LMNA', 'Lipodystrophy-include-LMNA', 'AGER-therapeutic target of-Peripheral Arterial Disease', 'CDKN2A-found-Neoplasms', 'NFE2L2-protect-Inflammation', 'CDKN2A-found-Colorectal Neoplasms', 'NFE2L2-protect-Neoplasms', 'HK2-prevent-Glucose Metabolism Disorders', 'Cholesterol-increase-Hypercholesterolemia', 'Cholesterol-increase-Synucleinopathies', 'Reperfusion Injury-lead-MEIS1', 'Wounds and Injuries-lead-MEIS1', 'PARP1-associated-Inflammation', 'Inflammation-associated-PARP1', 'PARP1-associated-Neoplasms', 'Neoplasms-associated-PARP1', 'Ataxia Telangiectasia-suffer-Inflammation', 'Diabetes Mellitus-be group of-Metabolic Diseases', 'Diabetes Mellitus-be group of-INS', 'Metabolic Diseases-characterized-INS', 'Metabolic Diseases-result-INS', 'Alzheimer Disease-lead-Neurodegenerative Diseases', 'RAB10-lead-Neurodegenerative Diseases', 'Infections-be with-Tuberculosis', 'Infections-generate-CD4', 'FLG-predispose to-Asthma', 'FLG-predispose-Rhinitis, Allergic', 'FLG-predispose-Drug Hypersensitivity', 'FLG-be in-Dermatitis, Atopic', 'FLG-predispose-Dermatitis, Atopic', 'Chondroitin Sulfates-reduce-Drug-Related Side Effects and Adverse Reactions', 'CST3-identify-Obesity', 'CST3-identify-Chronic Kidney Disease-Mineral and Bone Disorder', 'Myalgia-induced-Glycerol', 'Glutathione-implicated-Multiple Sclerosis', 'Glutathione-implicated-Neoplasms', 'PDE9A-be elevated with-Dementia', 'Immunologic Deficiency Syndromes-associated-Xerostomia', 'Xerostomia-associated-Immunologic Deficiency Syndromes', 'Immunologic Deficiency Syndromes-associated-Skin Diseases', 'Skin Diseases-associated-Immunologic Deficiency Syndromes', 'Immunologic Deficiency Syndromes-associated-Dermatitis, Atopic', 'Dermatitis, Atopic-associated-Immunologic Deficiency Syndromes', 'Immunologic Deficiency Syndromes-associated-Psoriasis', 'Psoriasis-associated-Immunologic Deficiency Syndromes', 'Xerostomia-associated-Skin Diseases', 'Skin Diseases-associated-Xerostomia', 'Xerostomia-associated-Dermatitis, Atopic', 'Dermatitis, Atopic-associated-Xerostomia', 'Xerostomia-associated-Psoriasis', 'Psoriasis-associated-Xerostomia', 'Ceramides-cause-Xerostomia', 'Ceramides-associated-Skin Diseases', 'Skin Diseases-associated-Ceramides', 'Ceramides-associated-Dermatitis, Atopic', 'Dermatitis, Atopic-associated-Ceramides', 'Ceramides-associated-Psoriasis', 'Psoriasis-associated-Ceramides', 'DCTN1-characterized-Parkinson Disease, Secondary', 'rs774688955-elevate-Myocardial Infarction', 'DCTN1-characterized-Atrophy', 'rs886039227-characterized-Parkinson Disease, Secondary', 'rs886039227-characterized-Atrophy', 'Urinary Retention-resemble-Cardiovascular Diseases', 'Urinary Retention-observed-Progeria', 'Fibrosis-resemble-Cardiovascular Diseases', 'Fibrosis-observed-Progeria', 'Atherosclerosis-resemble-Cardiovascular Diseases', 'Atherosclerosis-observed-Progeria', 'Cardiovascular Diseases-observed-Progeria', 'Gaucher Disease-affect-Metabolic Diseases', 'Leukodystrophy, Globoid Cell-affect-Metabolic Diseases', 'Glaucoma-determined-FSTL3', 'Cataract-determined-FSTL3', 'Alzheimer Disease-restore-INS', 'Alzheimer Disease-affect-Metabolic Syndrome', 'Diabetes Mellitus-restore-INS', 'Alzheimer Disease-restore-Glucose', 'Alzheimer Disease-hyperphosphorylate-MAPT', 'GALC-investigate-Parkinson Disease', 'Diabetes Mellitus-restore-Glucose', 'GALC-investigate-Alzheimer Disease', 'Psychosine-investigate-Parkinson Disease', 'Psychosine-investigate-Alzheimer Disease', 'GGH-include-Obesity', 'GGH-include-Neoplasms', 'GGH-include-Diabetes Mellitus', 'Kidney Diseases-associated-Neurologic Manifestations', 'Neurologic Manifestations-associated-Kidney Diseases', 'Aneurysm-associated-Neurologic Manifestations', 'Neurologic Manifestations-associated-Aneurysm', 'Kidney Diseases-associated-VEGFA', 'VEGFA-associated-Kidney Diseases', 'Aneurysm-associated-VEGFA', 'VEGFA-associated-Aneurysm', 'Aneuploidy-reported-Lewy Body Disease', 'Lewy Body Disease-reported-Aneuploidy', 'ATF4-mediated-Leukemia', 'SMURF2-be in-Progeria', 'Hypotension-make-Diabetes Mellitus', 'Hypotension-make-Hypertension', 'SLC5A2-make-Diabetes Mellitus', 'Hypotension-consider-Hypertension', 'SLC5A2-make-Hypertension', 'INS-engage-Hypotension', 'INS-consider-Hypertension', 'SLC5A2-suppress-Cardiovascular Diseases', 'LMNA-linked-Coronaviridae Infections', 'SLC5A2-suppress-Diabetic Nephropathies', 'Diabetes Mellitus-accompanied-Hypertension', 'Glucose-be important for-Diabetes Mellitus', 'Glucose-be important for-Hypertension', 'Glucose-accompanied-Hypertension', 'Pulmonary Disease, Chronic Obstructive-receive-Pneumococcal Infections', 'Pulmonary Disease, Chronic Obstructive-receive-Polysaccharides', 'Obesity-favor-Cardiovascular Diseases', 'Dyslipidemias-favor-Cardiovascular Diseases', 'Obesity-type-Diabetes Mellitus', 'Thrombosis-favor-Cardiovascular Diseases', 'HIV Infections-initiate-CD4', 'INS-type-Diabetes Mellitus', 'INS-favor-Cardiovascular Diseases', 'Sphingolipids-correct perturbations in-Sphingolipidoses', 'Aneurysm-include-SMAD2', 'Aneurysm-respond-SMAD2', 'Wounds and Injuries-include-SMAD2', 'Wounds and Injuries-respond-SMAD2', 'LEP-detected-Amyloidosis', 'Glucose-maintain-Diabetes Mellitus', 'Alzheimer Disease-related-Hyperkinesis', 'Infliximab-augment-Hyperkinesis', 'Infliximab-control-Hyperkinesis', 'GADD45B-be elevated in-Prostatic Neoplasms', 'KL-treat-Renal Insufficiency, Chronic', 'KL-treat-Neoplasms', 'Torsades de Pointes-be in-Inflammation', 'Inflammation-impact-Sarcopenia', 'Muscular Diseases-impact-Sarcopenia', 'Fatty Acids, Omega-3-prevent-INS', 'Inflammation-decrease-Obesity', 'Inflammation-prevent-INS', 'Muscular Diseases-prevent-INS', 'INS-impact-Sarcopenia', 'Fatty Acids, Omega-3-attenuate-Inflammation', 'Fatty Acids, Omega-3-decrease-Obesity', 'Fatty Acids, Omega-3-attenuate-Muscular Diseases', 'Fatty Acids, Omega-3-impact-Sarcopenia', 'MTOR-involved-Diabetes Mellitus', 'ATM-cause-Ataxia Telangiectasia', 'ATM-cause-Neurodegenerative Diseases', 'ATM-cause-Cerebellar Diseases', 'ATM-cause-Neoplasms', 'ATM-cause-Diabetes Mellitus', 'MAPT-mitigate-Alzheimer Disease', 'Thrombosis-use-Heparin, Low-Molecular-Weight', 'Edema-use-Heparin, Low-Molecular-Weight', 'Glucose-related-Heart Failure', 'Cholesterol-related-Myocardial Infarction', 'Cholesterol-be related-Heart Failure', 'Glucose Metabolism Disorders-associated-Bone Marrow Diseases', 'Bone Marrow Diseases-associated-Glucose Metabolism Disorders', 'Glucose Metabolism Disorders-associated-Pleural Effusion', 'Pleural Effusion-associated-Glucose Metabolism Disorders', 'Glucose Metabolism Disorders-associated-Osteoarthritis', 'Osteoarthritis-associated-Glucose Metabolism Disorders', 'Inflammation-associated-Bone Marrow Diseases', 'Bone Marrow Diseases-associated-Inflammation', 'Inflammation-associated-Pleural Effusion', 'Pleural Effusion-associated-Inflammation', 'CRP-associated-Bone Marrow Diseases', 'Bone Marrow Diseases-associated-CRP', 'CRP-associated-Pleural Effusion', 'Pleural Effusion-associated-CRP', 'CRP-associated-Osteoarthritis', 'Osteoarthritis-associated-CRP', 'Glucose-associated-Bone Marrow Diseases', 'Bone Marrow Diseases-associated-Glucose', 'Glucose-associated-Pleural Effusion', 'Pleural Effusion-associated-Glucose', 'Glucose-associated-Osteoarthritis', 'Osteoarthritis-associated-Glucose', 'SLTM-found-Neoplasms', 'SLTM-related-Neoplasms', 'SLTM-related-Breast Neoplasms', 'SLTM-found-Breast Neoplasms', 'SLTM-found-Diabetes Mellitus', 'SLTM-related-Diabetes Mellitus', 'Lung Diseases, Interstitial-increase-Death', 'HCRT-cause-Sleep Wake Disorders', 'CASR-increase-Death', 'HCRT-used-Sleep Initiation and Maintenance Disorders', 'HCRT-cause-Sleep Initiation and Maintenance Disorders', 'Myelodysplastic Syndromes-mimic-Anemia', 'Neoplasms-distinguish-Craniopharyngioma', 'Pulmonary Blastoma-distinguish-Craniopharyngioma', 'Hypophysitis-distinguish-Craniopharyngioma', 'Rupture-distinguish-Craniopharyngioma', 'Central Nervous System Cysts-distinguish-Craniopharyngioma', 'Adenoma, Oxyphilic-distinguish-Craniopharyngioma', 'Adenoma, Oxyphilic-base-NKX2-1', 'Demyelinating Diseases-find-Leukoencephalopathies', 'Demyelinating Diseases-find-Multiple Sclerosis', 'BCAS1-reformed-Demyelinating Diseases', 'BCAS1-find in-Leukoencephalopathies', 'BCAS1-find in-Multiple Sclerosis', 'Inflammation-play role in-Diabetic Nephropathies', 'Inflammation-attenuate-Kidney Diseases', 'Amyloidosis-occur-Cerebral Amyloid Angiopathy, Familial', 'Amyloidosis-occur-CST3', 'Inflammation-shown-Pentosan Sulfuric Polyester', 'Diabetic Nephropathies-shown-Pentosan Sulfuric Polyester', 'Pentosan Sulfuric Polyester-attenuate-Kidney Diseases', 'Pentosan Sulfuric Polyester-attenuate-Diabetes Mellitus', 'Infertility, Female-measure-AMH', 'MAPT-underlie-Dementia', 'Glucose Metabolism Disorders-controlled-Insulin Resistance', 'Hypothermia-associated-Valproic Acid', 'Valproic Acid-associated-Hypothermia', 'Glucose Metabolism Disorders-controlled-Glucose', 'Glucose-controlled-Insulin Resistance', 'TP63-reveal-Progeria', 'TP63-reveal-Rothmund-Thomson Syndrome', 'MAPT-underlie-Alzheimer Disease', 'Diabetes Mellitus-receive-Peripheral Nervous System Diseases', 'INS-manage-Diabetes Mellitus', 'INS-receive-Peripheral Nervous System Diseases', 'Glomerulonephritis-include-Kidney Diseases', 'CD79A-include-Kidney Diseases', 'Glomerulonephritis-include-CD79A', 'Glucose Intolerance-be in-Diabetes Mellitus', 'Glucose Intolerance-improve-Diabetes Mellitus', 'Pancreatitis-inhibit-Chemical and Drug Induced Liver Injury', 'Pancreatitis-treat-Obesity', 'Pancreatitis-suppress-Diabetes Mellitus', 'Obesity-modify-Hyperinsulinism', 'Triglycerides-treat-SIRT6', 'Pancreatitis-suggest-SIRT6', 'Chemical and Drug Induced Liver Injury-suggest-SIRT6', 'SIRT6-promising molecules for-Obesity', 'SIRT6-treat-Obesity', 'Obesity-involve-INS', 'SIRT6-treat-Diabetes Mellitus', 'Hyperinsulinism-involve-INS', 'Pancreatitis-inhibit-Triglycerides', 'Neoplasms-treated-TNF', 'INS-involve-Metabolic Diseases', 'Alzheimer Disease-show-Memory Disorders', 'rs7695558-develop-Alzheimer Disease', 'rs7695558-show-Memory Disorders', 'KL-defined-Renal Insufficiency, Chronic', 'Alzheimer Disease-involved-Glucose Metabolism Disorders', 'Alzheimer Disease-influence-Amyloidosis', 'SIRT1-involved-Pulmonary Disease, Chronic Obstructive', 'Inflammation-control-Arbovirus Infections', 'Neoplasms-control-Arbovirus Infections', 'Cardiovascular Diseases-control-Arbovirus Infections', 'FOXO3-control-Arbovirus Infections', 'rs12212067-control-Arbovirus Infections', 'Diabetes Mellitus-diagnosed-Hypertension', 'Diabetes Mellitus-diagnosed-Hypercholesterolemia', 'Glucose-contribute to-Cardiovascular Diseases', 'Diabetes Mellitus-diagnosed-Glucose', 'Diabetes Mellitus-diagnosed-Cholesterol', 'Mitochondrial Diseases-increase-Inflammation', 'CYP19A1-of involvement be-Prolactinoma', 'Gout-associated-Fever', 'Fever-associated-Gout', 'Gout-associated-Arthritis, Infectious', 'Arthritis, Infectious-associated-Gout', 'Gout-resemble-Arthritis, Infectious', 'CYBB-summarize-Inflammation', 'Fever-resemble-Arthritis, Infectious', 'Gout-associated-CRP', 'CRP-associated-Gout', 'CYBB-summarize-Hypercholesterolemia', 'CRP-resemble-Arthritis, Infectious', 'Venous Thromboembolism-recommended-Spinal Cord Injuries', 'Heparin-recommended-Spinal Cord Injuries', 'Neoplasms-reduce-Drug-Related Side Effects and Adverse Reactions', 'MGMT-reduce-Drug-Related Side Effects and Adverse Reactions', 'Necrosis-identified-ADIPOQ', 'MAPT-seen-Parkinson Disease', 'Hypertension-associate with-Cardiovascular Diseases', 'CRP-mask-Hypertension', 'CRP-remain-Hypertension', 'Cholesterol-mask-Hypertension', 'HTT-include-Huntington Disease', 'HTT-include-Parkinson Disease, Secondary', 'Inflammation-associated-Delirium', 'Delirium-associated-Inflammation', 'CRP-use-Inflammation', 'CTCF-implicate-Neurodegenerative Diseases', 'CRP-use-Delirium', 'LMNA-cause-Coronary Artery Disease', 'LMNA-cause-Communicable Diseases', 'Triglycerides-worsen-CRP', 'Obesity-worsen-CRP', 'Polycystic Ovary Syndrome-worsen-CRP', 'Triglycerides-worsen-Glucose', 'Obesity-worsen-Glucose', 'Polycystic Ovary Syndrome-worsen-Glucose', 'Obesity-worsen-Triglycerides', 'Polycystic Ovary Syndrome-worsen-Triglycerides', 'PRKN-act-Neurologic Manifestations', 'PRKN-act-Parkinson Disease', 'Neurodegenerative Diseases-lead-APOE', 'MAPT-contribute-Drug-Related Side Effects and Adverse Reactions', 'MAPT-contribute-Tauopathies', 'Insulinoma-abrogate-Drug-Related Side Effects and Adverse Reactions', 'Death-be highest for-CD4', 'Insulinoma-abrogate-Streptozocin', 'Metabolic Syndrome-highlight-Communicable Diseases', 'ADIPOQ-highlight-Communicable Diseases', 'KL-decline-Kidney Diseases', 'KL-decline-Diabetes Mellitus', 'Fatty Liver-be in-Obesity', 'Fatty Liver-reduce-Obesity', 'Glucose-reduce-Fatty Liver', 'Glucose-be in-Obesity', 'Glucose-reduce-Obesity', 'ATM-associated-Neoplasms', 'Neoplasms-associated-ATM', 'ATM-participate-Neoplasms', 'ATM-associated-Breast Neoplasms', 'Breast Neoplasms-associated-ATM', 'ATM-participate-Breast Neoplasms', 'ATM-modify-Neoplasms', 'Primary Immunodeficiency Diseases-be with-Lymphopenia', 'MSN-associated-Primary Immunodeficiency Diseases', 'Primary Immunodeficiency Diseases-associated-MSN', 'MSN-associated-Lymphopenia', 'Lymphopenia-associated-MSN', 'Ceramides-promote-Atrophy', 'Ceramides-promote-Necrosis', 'Death-compared-Diabetes Mellitus', 'Death-compared-Hypertension', 'Death-compared-Chagas Disease', 'Carcinoma, Merkel Cell-express-Neoplasms', 'Myelodysplastic Syndromes-be with-Thrombocytopenia', 'Immunologic Deficiency Syndromes-cause-Inflammation', 'THPO-represent-Myelodysplastic Syndromes', 'Death-compared-Cholesterol', 'THPO-represent-Thrombocytopenia', 'Leukemia, Myeloid, Acute-induce-Hemorrhage', 'THPO-induce-Hemorrhage', 'Myelodysplastic Syndromes-suffer-Hemorrhage', 'THPO-result-Myelodysplastic Syndromes', 'THPO-result-Hemorrhage', 'THPO-suffer-Hemorrhage', 'Lung Injury-include-Inflammation', 'Stomach Diseases-include-Inflammation', 'Dermatitis-include-Inflammation', 'Drug Hypersensitivity-include-Inflammation', 'INS-increase-Death', 'TXN-induced-Metabolic Diseases', 'TXN-be effective in-Drug Hypersensitivity', 'TXN-induced-Infections', 'INS-increase risk among-Diabetes Mellitus', 'TXN-induced-Inflammation', 'INS-cause-Weight Gain', 'INS-cause-Hypoglycemia', 'INS-cause-Iatrogenic Disease', 'INS-predispose to-Inflammation', 'INS-predispose-Atherosclerosis', 'INS-predispose-Hypertension', 'INS-predispose-Dyslipidemias', 'INS-predispose-Heart Failure', 'INS-predispose-Arrhythmias, Cardiac', 'Neurotoxicity Syndromes-modulate-Niemann-Pick Disease, Type A', 'Neurotoxicity Syndromes-attenuate-Parkinson Disease', 'Niemann-Pick Disease, Type A-point-Parkinson Disease', 'Cholesterol-attenuate-Neurotoxicity Syndromes', 'Atrophy-occur-Death', 'Cholesterol-point-Parkinson Disease', 'Mitochondrial Diseases-lead-PRKAA2', 'Immunologic Deficiency Syndromes-associated-Liver Failure, Acute', 'Liver Failure, Acute-associated-Immunologic Deficiency Syndromes', 'Immunologic Deficiency Syndromes-associated-Argininosuccinic Aciduria', 'Argininosuccinic Aciduria-associated-Immunologic Deficiency Syndromes', 'Immunologic Deficiency Syndromes-associated-End Stage Liver Disease', 'End Stage Liver Disease-associated-Immunologic Deficiency Syndromes', 'Immunologic Deficiency Syndromes-associated-Fibrosis', 'Fibrosis-associated-Immunologic Deficiency Syndromes', 'OTC-associated-Liver Failure, Acute', 'Liver Failure, Acute-associated-OTC', 'OTC-associated-Argininosuccinic Aciduria', 'Argininosuccinic Aciduria-associated-OTC', 'OTC-associated-End Stage Liver Disease', 'End Stage Liver Disease-associated-OTC', 'OTC-associated-Fibrosis', 'Fibrosis-associated-OTC', 'YAP1-act-Neoplasms', 'YAP1-act-Breast Neoplasms', 'CPB2-be in-Stroke', 'von Willebrand Diseases-ameliorate-Hemorrhage', 'von Willebrand Diseases-age related increase in-VWF', 'von Willebrand Diseases-experience-VWF', 'VWF-ameliorate-Hemorrhage', 'VWF-include-von Willebrand Disease, Type 1', 'VWF-include-Hemorrhage', 'VWF-be in-von Willebrand Diseases', 'SIRT6-occur-Inflammation', 'SIRT6-occur-Sepsis', 'TNFRSF11B-released-Vascular System Injuries', 'TNFRSF11B-released-Inflammation', 'TNFRSF11B-released-Atherosclerosis', 'Epilepsy-exhibit-Learning Disabilities', 'Epilepsy-exhibit-Glucose', 'TNFRSF11B-mediate-Vascular Calcification', 'TNFRSF11B-mediate-Communicable Diseases', 'TNFRSF11B-used-Cardiovascular Diseases', 'TNFRSF11B-used-Communicable Diseases', 'ANGPTL2-receive-Cardiovascular Diseases', 'ANGPTL2-receive-Heart Failure', 'Inflammation-accelerate-Cardiovascular Diseases', 'ANGPTL2-lead CVD development to-Inflammation', 'ANGPTL2-lead-Cardiovascular Diseases', 'ANGPTL2-accelerate-Cardiovascular Diseases', 'ANGPTL2-delay-Cardiovascular Diseases', 'ANGPTL2-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-ANGPTL2', 'ANGPTL2-associated-Heart Failure', 'Heart Failure-associated-ANGPTL2', 'GJB6-expressed-Neurodegenerative Diseases', 'Malaria-correlate-Parasitemia', 'Microvascular Angina-correlate-Parasitemia', 'BPIFB4-represent-Cerebrovascular Disorders', 'Sphingolipids-accumulating in-Gaucher Disease', 'Ulcer-associated-Atrial Fibrillation', 'Atrial Fibrillation-associated-Ulcer', 'Ulcer-associated-Coronary Artery Disease', 'Coronary Artery Disease-associated-Ulcer', 'Parkinson Disease-be in-Gaucher Disease', 'Ulcer-associated-ALB', 'ALB-associated-Ulcer', 'rs3796529-associated-Atrophy', 'Atrophy-associated-rs3796529', 'SIRT4-protect-Death', 'Hyperinsulinism-include-Cardiovascular Diseases', 'Obesity-include-Cardiovascular Diseases', 'Cardiovascular Diseases-known-Metabolic Syndrome', 'Hyperinsulinism-known-Metabolic Syndrome', 'Obesity-known-Metabolic Syndrome', 'Obesity-induce-LEP', 'Glucose-known-Metabolic Syndrome', 'Death-do-Diabetes Mellitus', 'Anophthalmos-induced-FUS', 'Neoplasms-reduce-Diabetes Mellitus', 'Neoplasms-reduce-Cardiovascular Diseases', 'Diabetes Mellitus-compare-Cardiovascular Diseases', 'Neoplasms-receive-INS', 'Cardiovascular Diseases-compare-INS', 'Oxylipins-increase-Inflammation', 'Oxylipins-increase-Hypertension', 'Oxylipins-increase-Blood Platelet Disorders', 'Anemia-defined-Hypoalbuminemia', 'Anemia-defined-ALB', 'Alzheimer Disease-base-Glucose', 'Dementia, Vascular-base-Glucose', 'rs9939609-associated-Death', 'Death-associated-rs9939609', 'Hyperinsulinism-play-Hyperandrogenism', 'Hyperinsulinism-play-Polycystic Ovary Syndrome', 'INSR-play-Hyperandrogenism', 'INSR-play-Polycystic Ovary Syndrome', 'Glucose Metabolism Disorders-diminished-Inflammation', 'NRGN-use-Alzheimer Disease', 'NRGN-use-Dementia', 'Obesity-contribute-Cardiovascular Diseases', 'Diabetes Mellitus-contribute-Cardiovascular Diseases', 'Death-examine-Chronic Disease', 'Death-live-CRP', 'ESR1-influenced-Obesity', 'ESR1-influenced-Breast Neoplasms', 'Alzheimer Disease-present-APOE', 'TRPC6-measure-Alzheimer Disease', 'Osteoporosis-note-Teriparatide', 'Denosumab-coupled-Bone Diseases', 'Autoimmune Diseases-cause-Neoplasms', 'Atorvastatin-reduce-CRP', 'CRP-reverse-Carotid Artery Diseases', 'CRP-reverse-Diabetes Mellitus', 'Atorvastatin-delay-Carotid Artery Diseases', 'Atorvastatin-reverse-Carotid Artery Diseases', 'Atorvastatin-delay progress with-Diabetes Mellitus', 'Atorvastatin-reverse-Diabetes Mellitus', 'Diabetic Foot-be with-Gangrene', 'Diabetic Foot-compare-CRP', 'Gangrene-compare-CRP', 'USP22-inhibit-Neoplasms', 'Fanconi Anemia-contribute-Neoplasms', 'Fanconi Anemia-contribute-FANCD2', 'FANCD2-contribute-Neoplasms', 'Hepatitis B-identify-Carcinoma, Hepatocellular', 'Glutathione-predict-Death', 'Hepatitis B-identify-Death', 'SLC13A5-regulate-Chemical and Drug Induced Liver Injury', 'SLC13A5-regulate-Carcinoma, Hepatocellular', 'Chemical and Drug Induced Liver Injury-influence-Carcinoma, Hepatocellular', 'Chemical and Drug Induced Liver Injury-facilitate-Carcinoma, Hepatocellular', 'SLC13A5-expand-Chemical and Drug Induced Liver Injury', 'SLC13A5-facilitate-Chemical and Drug Induced Liver Injury', 'SLC13A5-expand-Carcinoma, Hepatocellular', 'SLC13A5-influence-Carcinoma, Hepatocellular', 'Alzheimer Disease-correlate-Diabetes Mellitus, Type 2', 'Inflammation-explored-Osteoarthritis', 'Alginates-protect-Inflammation', 'Alginates-explored-Osteoarthritis', 'Blind Loop Syndrome-related-PDGFRB', 'Blind Loop Syndrome-arise-PDGFRB', 'Diabetes Mellitus-be in-Glucose', 'Infections-treat-Neurodegenerative Diseases', 'SIRT3-fight-Infections', 'Hypotension-worsen-Erectile Dysfunction', 'SIRT3-base-Neurodegenerative Diseases', 'SIRT3-treat-Neurodegenerative Diseases', 'SIRT3-support-Infections', 'SLC17A5-worsen-Erectile Dysfunction', 'GCG-increase-Diabetes Mellitus, Type 2', 'IAPP-related-Diabetes Mellitus', 'IAPP-related-Myotonic Dystrophy', 'Sotos Syndrome-be in-Myelodysplastic Syndromes', 'Sotos Syndrome-lead-TLR4', 'SIRT1-implicated-Neurodegenerative Diseases', 'Diabetes Mellitus-have recognize as-Dementia', 'Diabetes Mellitus-result-INS', 'Dementia-result-INS', 'Parkinson Disease-observed-SIRT1', 'Dementia-activity of-SIRT1', 'Dementia-observed-SIRT1', 'Alzheimer Disease-observed-SIRT1', 'Weight Loss-cause-Glucose Intolerance', 'Aspartame-lead-Weight Loss', 'Aspartame-cause-Glucose Intolerance', 'LMNA-lead-Aging, Premature', 'Muscular Diseases-induce-Inflammation', 'Muscular Diseases-induce-INS', 'Inflammation-indicated-CRP', 'Polyomavirus Infections-associated-Carcinoma, Merkel Cell', 'Carcinoma, Merkel Cell-associated-Polyomavirus Infections', 'SHH-associated-Carcinoma, Merkel Cell', 'Carcinoma, Merkel Cell-associated-SHH', 'FGF21-control-Hypothalamic Neoplasms', 'Diabetes Mellitus-associated-CST3', 'CST3-associated-Diabetes Mellitus', 'Diabetic Nephropathies-associated-CST3', 'CST3-associated-Diabetic Nephropathies', 'Fructose-increased-INS', 'Death-be high-CD4', 'Fructose-increased-Inflammation', 'ALPP-link-Vascular Calcification', 'ALPP-link-Inflammation', 'ALPP-link-Cardiovascular Diseases', 'Sleep Wake Disorders-associated-Olfaction Disorders', 'Olfaction Disorders-associated-Sleep Wake Disorders', 'APOE-associated-Olfaction Disorders', 'Olfaction Disorders-associated-APOE', 'Cardiovascular Diseases-show-Myocardial Infarction', 'CDC42-show-Myocardial Infarction', 'CDC42-validate-Cardiovascular Diseases', 'CDC42-validate-Myocardial Infarction', 'NOLC1-decreased-Carcinoma, Hepatocellular', 'NOLC1-repress-Neoplasms', 'Nervous System Diseases-caused-PMP22', 'PMP22-caused-Pain Insensitivity, Congenital', 'VWF-proposed-Aortic Valve Stenosis', 'VWF-proposed-Heart Valve Diseases', 'VWF-proposed-Hemorrhage', 'CD4-associated-Hypertension', 'Hypertension-associated-CD4', 'Muscular Atrophy-mediate-Heart Arrest', 'DOT1L-mediate-Muscular Atrophy', 'Diabetes Mellitus-develop-Hypoglycemia', 'Diabetes Mellitus-suffer-Hypoglycemia', 'Diabetes Mellitus-controlled-INS', 'INS-suffer-Hypoglycemia', 'MAPT-support-Alzheimer Disease', 'Acute Kidney Injury-associated-Hypertension', 'Hypertension-associated-Acute Kidney Injury', 'Acute Kidney Injury-associated-Proteinuria', 'Proteinuria-associated-Acute Kidney Injury', 'Enalapril-associated-ACE', 'ACE-associated-Enalapril', 'Acute Kidney Injury-associated-INS', 'INS-associated-Acute Kidney Injury', 'Heart Failure-associated-ACE', 'ACE-associated-Heart Failure', 'Death-compare-Enalapril', 'Heart Failure-compare-Enalapril', 'APOE-encode-Alzheimer Disease', 'Metabolic Diseases-establish-FNDC5', 'FNDC5-treat-Osteoporosis', 'APOE-involved-Demyelinating Diseases', 'Neurodegenerative Diseases-see-Alzheimer Disease', 'Neurodegenerative Diseases-see-Parkinson Disease', 'Atrial Fibrillation-associated-PITX2', 'PITX2-associated-Atrial Fibrillation', 'Obesity, Abdominal-associate-INS', 'INS-associate-Obesity, Abdominal', 'Metabolic Syndrome-associate-INS', 'INS-associate-Metabolic Syndrome', 'Acute Kidney Injury-be independent predictors of-Death', 'ALB-be independent predictors of-Death', 'CISD2-implicated-Diabetes Mellitus', 'CISD2-implicated-Neurodegenerative Diseases', 'CISD2-implicated-Cardiovascular Diseases', 'Myositis-associated-Muscular Diseases', 'Muscular Diseases-associated-Myositis', 'Myositis-associated-GNE', 'GNE-associated-Myositis', 'Muscular Diseases-associated-GNE', 'GNE-associated-Muscular Diseases', 'Neoplasms-be with-Hepatitis B', 'Sexual Dysfunction, Physiological-correlate-Renal Insufficiency, Chronic', 'HIV Infections-associated-Metabolic Syndrome', 'Metabolic Syndrome-associated-HIV Infections', 'CD4-exposure to-Phosphatidylinositols', 'CD4-associated-Metabolic Syndrome', 'Metabolic Syndrome-associated-CD4', 'Phosphatidylinositols-associated-Metabolic Syndrome', 'Metabolic Syndrome-associated-Phosphatidylinositols', 'KL-protect-Atherosclerosis', 'Sleepiness-associated-INS', 'INS-associated-Sleepiness', 'Hypertension-consult-Asthenia', 'Sleep Apnea, Obstructive-associated-INS', 'INS-associated-Sleep Apnea, Obstructive', 'Hypertension-associated-Ketosis', 'Ketosis-associated-Hypertension', 'Asthenia-consult-Polyuria', 'Asthenia-consult-Diabetes Mellitus', 'Asthenia-associated-Ketosis', 'Ketosis-associated-Asthenia', 'Polyuria-reveal-Diabetes Mellitus', 'Polyuria-associated-Ketosis', 'Ketosis-associated-Polyuria', 'Diabetes Mellitus-associated-Ketosis', 'Ketosis-associated-Diabetes Mellitus', 'Hypertension-reveal-Glucose', 'Asthenia-reveal-Glucose', 'Polyuria-reveal-Glucose', 'Glucose-reveal-Diabetes Mellitus', 'Glucose-reveal-Ketosis', 'Glucose-associated-Ketosis', 'Ketosis-associated-Glucose', 'Low Back Pain-base-Pain', 'BDNF-base-Pain', 'Low Back Pain-exhibit-Pain', 'Low Back Pain-exhibit-BDNF', 'Dementia-perform-APOE', 'Vision Disorders-perform-APOE', 'BDNF-exhibit-Pain', 'Atrophy-require for-Muscular Atrophy', 'ATF4-induce-Atrophy', 'ATF4-induce-Muscular Atrophy', 'Diabetes Mellitus-result-Abnormalities, Drug-Induced', 'SIRT6-targeted-Alzheimer Disease', 'Diabetes Mellitus-result-Pancreatitis', 'SIRT6-targeted-Neurodegenerative Diseases', 'Diabetes Mellitus-result-Glucose', 'GPER1-propagate-Hypertension', 'Genetic Diseases, Inborn-lead-Obesity', 'Inflammation-associated-Brain Diseases', 'Brain Diseases-associated-Inflammation', 'Nerve Degeneration-associated-Brain Diseases', 'Brain Diseases-associated-Nerve Degeneration', 'TMEM106B-associated-Inflammation', 'Inflammation-associated-TMEM106B', 'TMEM106B-associated-Nerve Degeneration', 'Nerve Degeneration-associated-TMEM106B', 'TARDBP-occur-TDP-43 Proteinopathies', 'Infliximab-mediate-Muscular Diseases', 'Infliximab-exacerbate-Mitochondrial Diseases', 'Chronic Disease-characterised-Hyperglycemia', 'Chronic Disease-characterised-Hyperinsulinism', 'Chronic Disease-characterised-INS', 'Chronic Disease-use-Glucose', 'Hyperglycemia-use-Glucose', 'Hyperinsulinism-use-Glucose', 'rs1805017-related-INS', 'rs1805017-involved-Polycystic Ovary Syndrome', 'rs1805017-involved-Cardiovascular Diseases', 'Inflammation-associated-Sarcopenia', 'Sarcopenia-associated-Inflammation', 'Neurogenic Inflammation-reduce-Alzheimer Disease', 'Neurogenic Inflammation-treat-Neurodegenerative Diseases', 'Neurogenic Inflammation-explore-Alzheimer Disease', 'Alzheimer Disease-reduce-Neurodegenerative Diseases', 'Alzheimer Disease-treat-Neurodegenerative Diseases', 'Neurodegenerative Diseases-reduce-Alzheimer Disease', 'Neurodegenerative Diseases-explore-Alzheimer Disease', 'Neurogenic Inflammation-explain-Glycerophospholipids', 'Alzheimer Disease-reduce-Glycerophospholipids', 'Alzheimer Disease-explain-Glycerophospholipids', 'Neurodegenerative Diseases-explain-Glycerophospholipids', 'Glycerophospholipids-reduce-Alzheimer Disease', 'Glycerophospholipids-explore-Alzheimer Disease', 'Aneurysm-include-Neurodegenerative Diseases', 'Mitochondrial Diseases-include-Neurodegenerative Diseases', 'MTOR-implicated-Diabetes Mellitus', 'Brain Injuries-induced-Diabetes Mellitus', 'INS-show-Diabetes Mellitus', 'Brain Injuries-associated-Hyperinsulinism', 'Hyperinsulinism-associated-Brain Injuries', 'INS-show-Brain Injuries', 'Brain Injuries-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-Brain Injuries', 'Brain Injuries-associated-INS', 'INS-associated-Brain Injuries', 'NTRK1-utilize-Neoplasms', 'NTRK1-utilize-Pain', 'Gout-impair-Bacterial Infections', 'Gout-linked-NLRP3', '3-Hydroxybutyric Acid-alleviate-Gout', '3-Hydroxybutyric Acid-impair-Bacterial Infections', 'Nerve Degeneration-be in-Alzheimer Disease', 'Coronary Artery Disease-associated-Renal Insufficiency, Chronic', 'Renal Insufficiency, Chronic-associated-Coronary Artery Disease', 'Cholesterol-associated-Renal Insufficiency, Chronic', 'Renal Insufficiency, Chronic-associated-Cholesterol', 'Seizures-thrive-ASXL1', 'Congenital Abnormalities-thrive-ASXL1', 'Heart Failure-thrive-ASXL1', 'Diabetes Mellitus-affect-Glucose Metabolism Disorders', 'Diabetes Mellitus-interact-SLC30A8', 'SLC30A8-affect-Glucose Metabolism Disorders', 'NLRP3-obtained-Intervertebral Disc Degeneration', 'NLRP3-observe-Scoliosis', 'Carotid Artery Diseases-associated-ADIPOQ', 'ADIPOQ-associated-Carotid Artery Diseases', 'Osteogenesis Imperfecta-suffer-Bone Neoplasms', 'MAPK10-serve-Osteogenesis Imperfecta', 'MAPK10-suffer-Bone Neoplasms', 'CD8A-be effective at-Arbovirus Infections', 'CD8A-be effective at-Infections', 'CD8A-generated-Infections', 'KL-be related in-Diabetes Mellitus, Type 1', 'Obesity-appear-NR3C1', 'Diabetes Mellitus, Type 2-appear-NR3C1', 'Drug Hypersensitivity-appear-NR3C1', 'EREG-activated-Cachexia', 'Fanconi Anemia-be center of-Neoplasms', 'Fanconi Anemia-become-Neoplasms', 'FANCD2-be center of-Fanconi Anemia', 'AGER-form-Diabetes Mellitus', 'FANCD2-be center of-Neoplasms', 'AGER-form-Inflammation', 'AGER-form-Renal Insufficiency', 'AGER-collect-Obesity', 'EREG-important roles in-Muscular Diseases', 'Fanconi Anemia-compare-Neoplasms', 'Fanconi Anemia-perform-Neoplasms', 'FANCD2-compare-Fanconi Anemia', 'FANCD2-compare-Neoplasms', 'FANCD2-perform-Neoplasms', 'APOE-compare-Alzheimer Disease', 'Atherosclerosis-survive-Dementia', 'Cholesterol-be higher in-Atherosclerosis', 'Cholesterol-be higher as-Dementia', 'Cholesterol-survive-Dementia', 'Postoperative Cognitive Complications-modeled-CRP', 'Dementia-be with-Atherosclerosis', 'Hearing Loss-associated-Mitochondrial Diseases', 'Mitochondrial Diseases-associated-Hearing Loss', 'FUS-introduce-Hearing Loss', 'FUS-introduce-Mitochondrial Diseases', 'FUS-associated-Mitochondrial Diseases', 'Mitochondrial Diseases-associated-FUS', 'Death-independent predictors of be-Diabetes Mellitus', 'Dystonia-increase-Infections', 'FGF23-decrease-Dystonia', 'FGF23-increase-Infections', 'Neoplasms-inhibit-TNFSF11', 'Osteolysis-inhibit-TNFSF11', 'Breast Neoplasms-promote-Neoplasm Metastasis', 'Bone Diseases-alter-Neoplasms', 'MST1-elevated-Breast Neoplasms', 'MST1-promote-Neoplasm Metastasis', 'MST1R-alter-Bone Diseases', 'MST1R-be in-Neoplasms', 'MST1R-alter-Neoplasms', 'MST1R-normalize-Bone Neoplasms', 'Calcinosis-involve-Heart Failure, Diastolic', 'AHSG-involve-Heart Failure, Diastolic', 'KL-promote-Kidney Diseases', 'INS-include-HIV Infections', 'Nerve Degeneration-occur-MAPT', 'Alzheimer Disease-occur-MAPT', 'Inflammation-known-CDKN2A', 'Death-occur-Shock, Septic', 'Ceramides-predict-Alzheimer Disease', 'Muscular Diseases-implicated-MTOR', 'Diabetes Mellitus, Type 2-implicated-MTOR', 'Neoplasms-confer-Leukemia, Myeloid, Acute', 'DNMT3A-be early events during-Neoplasms', 'DNMT3A-confer-Leukemia, Myeloid, Acute', 'Emphysema-induce-Immunologic Deficiency Syndromes', 'Emphysema-induce-SERPINA1', 'Death-suffer-Fractures, Bone', 'ALB-suffer-Fractures, Bone', 'Fever-consider-Signs and Symptoms, Respiratory', 'Signs and Symptoms, Respiratory-misdiagnosed-Fever', 'Daptomycin-consider-Fever', 'Daptomycin-consider-Signs and Symptoms, Respiratory', 'Fever-misdiagnosed-Daptomycin', 'Fever-induced-Daptomycin', 'Hypoxia-postpone-Alzheimer Disease', 'Femoral Neck Fractures-benefit-ALB', 'Malnutrition-benefit-ALB', 'Death-benefit-ALB', 'Chronic Disease-characterized-Inflammation', 'Chronic Disease-characterized-Metabolic Diseases', 'AGER-accumulate-Chronic Disease', 'Alzheimer Disease-required-Neurodegenerative Diseases', 'AGER-characterized-Inflammation', 'MAPT-required-Neurodegenerative Diseases', 'AGER-characterized-Metabolic Diseases', 'Alzheimer Disease-target-MAPT', 'Synucleinopathies-target-MAPT', 'Neoplasms-compare-Acquired Immunodeficiency Syndrome', 'Neoplasms-compare-CD4', 'AGER-report-Neurodegenerative Diseases', 'Multiple Myeloma-associated-CD4', 'CD4-associated-Multiple Myeloma', 'CPE-cause-Memory Disorders', 'Carcinoma, Squamous Cell-drive-Neoplasms', 'RARRES2-promote-Carcinoma, Squamous Cell', 'RARRES2-drive-Neoplasms', 'VEGFA-compare-Arthritis, Rheumatoid', 'VEGFA-compare-Rheumatic Diseases', 'VEGFA-compare-Inflammation', 'VEGFA-compare-Edema', 'Jaundice, Neonatal-pointed-Niemann-Pick Disease, Type C', 'Splenomegaly-pointed-Niemann-Pick Disease, Type C', 'Hypertension-be with-Hypertriglyceridemia', 'Jaundice, Neonatal-confirm-Cholesterol', 'Niemann-Pick Disease, Type C-confirm-Cholesterol', 'Alzheimer Disease-remain-AIF1', 'Glucose Intolerance-rise-Hypotension', 'Diabetes Mellitus-rise-Hypotension', 'Glucose-rise-Hypotension', 'Glucose Intolerance-defined-Glucose', 'Glucose-defined-Diabetes Mellitus', 'NCOA5-be up regulated in-Breast Neoplasms', 'NCOA5-up-regulated-Breast Neoplasms', 'NCOA5-be up regulated compare-Neoplasms', 'Neoplasms-use-Stomach Neoplasms', 'UNG-use-Neoplasms', 'UNG-use-Stomach Neoplasms', 'Neoplasms-function-Breast Neoplasms', 'Neoplasms-reduced-Cachexia', 'MFN2-reduced-Neoplasms', 'MFN2-reduced-Cachexia', 'Hypothalamic Diseases-be in-Obesity', 'Hypothalamic Diseases-result-Obesity', 'Hypothalamic Diseases-result-Glucose Intolerance', 'CREBBP-be in-Obesity', 'CREBBP-result-Obesity', 'CREBBP-result-Glucose Intolerance', 'Aneurysm-potentiate-Hyperplasia', 'FAT1-expressed-Aneurysm', 'FAT1-potentiate-Hyperplasia', 'Glucose Metabolism Disorders-dysregulated-Glucose', 'Neoplasms-link-Seizures', 'PRKAA1-link-Seizures', 'ATF4-play-Calcinosis', 'ATF4-play-Diabetes Mellitus', 'ATF4-play-Renal Insufficiency, Chronic', 'Hypertension-prevent-Kidney Failure, Chronic', 'REN-prevent-Kidney Failure, Chronic', 'Neurodegenerative Diseases-predict-Alzheimer Disease', 'NEFL-predict-Neurodegenerative Diseases', 'NEFL-predict neurodegeneration with-Alzheimer Disease', 'Amyotrophic Lateral Sclerosis-downregulated-Inflammation', 'TOLLIP-downregulated-Lipopolysaccharides', 'TOLLIP-induced-Lipopolysaccharides', 'TOLLIP-downregulated-Amyotrophic Lateral Sclerosis', 'TOLLIP-downregulated-Inflammation', 'Amyotrophic Lateral Sclerosis-induced-Lipopolysaccharides', 'Canavan Disease-indicate-Neurodegenerative Diseases', 'Canavan Disease-indicate-NEFL', 'NEFL-indicate-Alzheimer Disease', 'NEFL-indicate-Neurodegenerative Diseases', 'Amyloidosis-risk for-Alzheimer Disease', 'Amyloidosis-increase-Alzheimer Disease', 'APOE-increase-Amyloidosis', 'Amyloidosis-related-APOE', 'Alzheimer Disease-related-APOE', 'Inflammation-associated-Osteoporotic Fractures', 'Osteoporotic Fractures-associated-Inflammation', 'Metabolic Syndrome-considered-Diabetes Mellitus', 'HIV Infections-associated-Osteoporotic Fractures', 'Osteoporotic Fractures-associated-HIV Infections', 'Inflammation-preserved-CD4', 'HIV Infections-preserved-CD4', 'CD4-associated-Osteoporotic Fractures', 'Osteoporotic Fractures-associated-CD4', 'CD4-preserved-Osteoporotic Fractures', 'KL-compare-Exfoliation Syndrome', 'KL-compare-Glaucoma', 'Atrial Fibrillation-suffer-Neurologic Manifestations', 'Dyslipidemias-suffer-Neurologic Manifestations', 'Cholesterol-use-Neurologic Manifestations', 'Cholesterol-suffer-Neurologic Manifestations', 'Renal Insufficiency, Chronic-associated-IL6', 'IL6-associated-Renal Insufficiency, Chronic', 'Obesity-decrease-Renal Insufficiency, Chronic', 'HMOX1-recognized-Granuloma', 'Death-increase-Necrosis', 'Infections-show-Granuloma', 'Calcinosis-render-KL', 'KL-render-Drug-Related Side Effects and Adverse Reactions', 'LAMP2-cause-Glycogen Storage Disease Type IIb', 'LAMP2-cause-Cardiomyopathy, Hypertrophic', 'Hypertension-ameliorate-Calcinosis', 'KL-ameliorate-Calcinosis', 'KL-ameliorate-Hypertension', 'ALPL-lead-Tooth Loss', 'Carcinoma, Non-Small-Cell Lung-produce-Bone Marrow Diseases', 'SHBG-associated-Bone Neoplasms', 'Bone Neoplasms-associated-SHBG', 'SHBG-associated-Fractures, Bone', 'Fractures, Bone-associated-SHBG', 'Liver Cirrhosis-occur with-INS', 'Prediabetic State-use-Glucose', 'Hyperglycemia-estimated-Prediabetic State', 'RGS2-discovered-Alzheimer Disease', 'Corneal Diseases-attenuate-Inflammation', 'TERC-modulate-Glucose Metabolism Disorders', 'TERC-interact-Inflammation', 'TERC-modulate-Coronary Artery Disease', 'TERC-interact-Coronary Artery Disease', 'HIV-Associated Lipodystrophy Syndrome-combined-INS', 'Adenomatous Polyposis Coli-be in-Breast Neoplasms', 'APC2-be in-Breast Neoplasms', 'Parkinson Disease-be with-LRRK2', 'Alzheimer Disease-associated-Infarction', 'Infarction-associated-Alzheimer Disease', 'TARDBP-described-Alzheimer Disease', 'TARDBP-associated-Infarction', 'Infarction-associated-TARDBP', 'TARDBP-associated-Arteriolosclerosis', 'Arteriolosclerosis-associated-TARDBP', 'TARDBP-associated-Sclerosis', 'Sclerosis-associated-TARDBP', 'MIR22-associated-Death', 'Death-associated-MIR22', 'Tooth Loss-associated-Chronic Disease', 'Chronic Disease-associated-Tooth Loss', 'Tooth Loss-associated-CRP', 'CRP-associated-Tooth Loss', 'MIR22-highlight-Cardiovascular Diseases', 'Mitochondrial Diseases-implicated-Inflammation', 'Denosumab-follow-Fractures, Bone', 'Mitochondrial Diseases-implicated-INS', 'CCL11-observed-Alzheimer Disease', 'CCL11-observed-Amyotrophic Lateral Sclerosis', 'CCL11-observed-Huntington Disease', 'CCL11-observed-Multiple Sclerosis', 'Coronary Stenosis-be in-Diabetes Mellitus', 'Glucose-be with-Triglycerides', 'Neoplasms-elucidate-Carcinoma, Hepatocellular', 'FOXP1-inhibit-Carcinoma, Hepatocellular', 'Neoplasms-elucidate-FOXP1', 'Heart Arrest-induce-Breast Neoplasms', 'CRP-detect-Infections', 'Heart Arrest-trigger-CDKN2A', 'CRP-provide-Sepsis', 'SHBG-associated-Prediabetic State', 'Prediabetic State-associated-SHBG', 'SHBG-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-SHBG', 'rs1141718-be in-SOD2', 'SOD2-linked-Parkinson Disease', 'SOD2-linked-Neoplasms', 'rs1141718-linked-Parkinson Disease', 'rs1141718-linked-Neoplasms', 'SHBG-be relevant factor for-Prediabetic State', 'SHBG-be relevant factor for-Diabetes Mellitus', 'KL-secreted-Atherosclerosis', 'KL-secreted-Cardiovascular Diseases', 'KL-secreted-Stroke', 'KL-secreted-Osteoporosis', 'PPIB-investigate-Neuroblastoma', 'Adrenal Insufficiency-result-Liver Failure', 'BUB1B-result-Liver Failure', 'Inflammation-release-Necrosis', 'HMGB1-trigger-Inflammation', 'HMGB1-release-Necrosis', 'Muscular Diseases-associated-Muscular Dystrophy, Duchenne', 'Muscular Dystrophy, Duchenne-associated-Muscular Diseases', 'Muscular Diseases-identified-DMD', 'Mucopolysaccharidosis II-cause-Neurodegenerative Diseases', 'Osteoporosis-treat-Osteoarthritis', 'Osteoporosis-treat-Bone Neoplasms', 'Lysosomal Storage Diseases-cause-Neurodegenerative Diseases', 'Osteoarthritis-treat-Bone Neoplasms', 'Osteoarthritis-treat-Fractures, Bone', 'PTH-approved-Osteoporosis', 'PTH-approved-Osteoarthritis', 'PTH-approved-Bone Neoplasms', 'PTH-approved-Fractures, Bone', 'Cardiotoxicity-lead to-Ventricular Dysfunction', 'Alzheimer Disease-characterised-MAPT', 'Anthracyclines-lead-Ventricular Dysfunction', 'PTH-used-Bone Neoplasms', 'Teriparatide-treat-Bone Diseases', 'Teriparatide-used-Bone Neoplasms', 'Lipid Metabolism Disorders-highlight-Triglycerides', 'Anemia-improve-Death', 'Capsaicin-be reasonable option-Rhinitis, Allergic', 'Neurodegenerative Diseases-analysed-KALRN', 'INS-compare-Glucose', 'INS-compare-Glucose Intolerance', 'INS-compare-Diabetes Mellitus', 'Glucose-compare-Glucose Intolerance', 'Rituximab-associated-Drug-Related Side Effects and Adverse Reactions', 'Drug-Related Side Effects and Adverse Reactions-associated-Rituximab', 'Neoplasms-related-Blood Coagulation Disorders', 'Neoplasms-cause-Blood Coagulation Disorders', 'F3-related-Neoplasms', 'BDNF-underlie-Atrophy', 'PIM1-tested-Neoplasms', 'PIM1-tested-Alzheimer Disease', 'APOE-provide-Brain Injuries', 'APOE-provide-Dementia', 'Renal Insufficiency, Chronic-demonstrate-Kidney Diseases', 'Hyperglycemia-hypothesized-Muscular Diseases', 'Hyperglycemia-hypothesized-Diabetes Mellitus', 'Nervous System Diseases-hypothesized-Muscular Diseases', 'Nervous System Diseases-hypothesized-Diabetes Mellitus', 'Cushing Syndrome-demonstrate-Kidney Diseases', 'Hypertension-demonstrate-Kidney Diseases', 'INS-hypothesized-Muscular Diseases', 'INS-hypothesized-Diabetes Mellitus', 'Cholesterol-demonstrate-Kidney Diseases', 'LOXL1-reported-Neoplasms', 'LOXL1-reported-Cutis Laxa', 'Drug-Related Side Effects and Adverse Reactions-be frequent during-Neutropenia', 'Drug-Related Side Effects and Adverse Reactions-reported-Neutropenia', 'Drug-Related Side Effects and Adverse Reactions-be frequent during-Doxorubicin', 'Doxorubicin-reported-Neutropenia', 'MAPT-compatible with-Tauopathies', 'Neurodegenerative Diseases-be in-Parkinson Disease', 'Leukemia, Myeloid-involved-Neoplasms', 'TNMD-associated-Cholesterol', 'Cholesterol-associated-TNMD', 'TNMD-associated-Obesity', 'Obesity-associated-TNMD', 'CENPU-involved-Neoplasms', 'TNMD-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-TNMD', 'TNMD-associated-Alzheimer Disease', 'Alzheimer Disease-associated-TNMD', 'Pulmonary Disease, Chronic Obstructive-related-Inflammation', 'Inflammation-play-NFKB1', 'Glucose-considered-Hyperglycemia', 'CST3-predict-Cardiovascular Diseases', 'CST3-predict risk for-Death', 'Thymus Neoplasms-reflect-FOXP3', 'Triglycerides-identify-Carcinoma, Hepatocellular', 'Triglycerides-identify-Diabetes Mellitus', 'SHBG-associate-Fractures, Bone', 'Fractures, Bone-associate-SHBG', 'SHBG-remain-Fractures, Bone', 'SHBG-associate-Hip Fractures', 'Hip Fractures-associate-SHBG', 'SHBG-remain-Hip Fractures', 'Osteoarthritis-considered-Osteoporotic Fractures', 'TGM2-considered-Osteoarthritis', 'Crack Cocaine-divided-Wounds and Injuries', 'Crack Cocaine-divided-Substance-Related Disorders', 'TGM2-considered-Osteoporotic Fractures', 'ATP6V1B2-involved-Alzheimer Disease', 'ATP6V1B2-impacted-Alzheimer Disease', 'Glucose-produce-Cardiovascular Diseases', 'Glucose-produce-Death', 'Glucose-produce-Hypoglycemia', 'Neurodegenerative Diseases-bear-Tauopathies', 'MAPT-bear-Neurodegenerative Diseases', 'Glucose Intolerance-culminate-INS', 'Williams Syndrome-involve-ELN', 'Congenital, Hereditary, and Neonatal Diseases and Abnormalities-involve-ELN', 'Rothmund-Thomson Syndrome-regulate-Neoplasms', 'Skin Diseases-carry-RECQL4', 'Bone Diseases, Metabolic-carry-RECQL4', 'RECQL4-mutated-Rothmund-Thomson Syndrome', 'RECQL4-regulate-Neoplasms', 'Cataract-carry-RECQL4', 'Neoplasms-carry-RECQL4', 'Metabolic Syndrome-related-INS', 'EGFR-occur-Neoplasms', 'EGFR-occur-Carcinoma, Squamous Cell', 'EZH2-regulate-Osteoporosis', 'SIRT6-protect-Atherosclerosis', 'Osteoarthritis-compare-Wounds and Injuries', 'SIRT1-inhibited-Osteoarthritis', 'SIRT1-inhibited-Wounds and Injuries', 'ASGR1-downregulated-Carcinoma, Hepatocellular', 'ASGR1-associated-Carcinoma, Hepatocellular', 'Carcinoma, Hepatocellular-associated-ASGR1', 'ASGR1-downregulated-Liver Neoplasms', 'Cardiovascular Abnormalities-defined-Obesity', 'SOD2-correlated-Neoplasms', 'C9orf72-identified-Amyotrophic Lateral Sclerosis', 'C9orf72-identified-Dementia', 'SOD2-correlated-Intracranial Embolism', 'Obesity-associated-Prediabetic State', 'Prediabetic State-associated-Obesity', 'Triglycerides-elevate-CRP', 'Obesity-elevate-CRP', 'CRP-associated-Prediabetic State', 'Prediabetic State-associated-CRP', 'Muscular Diseases-show-Muscle Weakness', 'rs61672878-reported-Muscular Diseases', 'rs61672878-show-Muscle Weakness', 'Triglycerides-associated-Prediabetic State', 'Prediabetic State-associated-Triglycerides', 'Inflammation-correlate-Plaque, Atherosclerotic', 'Pneumococcal Infections-show-Infections', 'Pneumococcal Infections-deciphered-AKT1', 'APOE-Possession of be-Alzheimer Disease', 'Atrophy-summarize-Alzheimer Disease', 'APOE-summarize-Alzheimer Disease', 'APOE-evolve-Alzheimer Disease', 'ADIPOQ-associated-Alzheimer Disease', 'Alzheimer Disease-associated-ADIPOQ', 'Metabolic Syndrome-associated-Glucose Intolerance', 'Glucose Intolerance-associated-Metabolic Syndrome', 'BAG3-implicated-Neoplasms', 'BAG3-implicated-Muscular Diseases', 'BAG3-implicated-Neurodegenerative Diseases', 'ADIPOQ-predict-Neurodegenerative Diseases', 'Inflammation-observed-Obesity', 'Inflammation-lead-Diabetes Mellitus', 'Inflammation-lead to-INS', 'CDKN2A-link-Diabetes Mellitus', 'Diabetes Mellitus-link-CDKN2B-AS1', 'CLEC3B-encode-Osteogenesis Imperfecta', 'CLEC3B-encode-Neoplasm Metastasis', 'KDR-assessed-Cerebral Small Vessel Diseases', 'KDR-assessed-CADASIL', 'KDR-assessed-Leukoencephalopathies', 'KDR-associated-Cerebral Small Vessel Diseases', 'Cerebral Small Vessel Diseases-associated-KDR', 'Ceramides-associate-Cardiovascular Diseases', 'Cardiovascular Diseases-associate-Ceramides', 'Ceramides-implicated-Seizures', 'Ceramides-associate-Seizures', 'Seizures-associate-Ceramides', 'Dyskeratosis Congenita-lead-Heart Failure', 'TINF2-encode-Dyskeratosis Congenita', 'KL-new therapeutic target for-Neurodegenerative Diseases', 'KL-become-Neurodegenerative Diseases', 'KL-become-Alzheimer Disease', 'Multiple Organ Failure-lead-KL', 'KL-become-Demyelinating Diseases', 'KL-become-Sclerosis', 'TREM2-linked-Alzheimer Disease', 'TREM2-linked-Neurodegenerative Diseases', 'Death-undergo-Sclerosis', 'Death-undergo-TARDBP', 'Gait Disorders, Neurologic-accompanied-Acute Disease', 'Paralysis-accompanied-Acute Disease', 'MAPT-induce-Gait Disorders, Neurologic', 'MAPT-induce-Paralysis', 'MAPT-accompanied-Acute Disease', 'ALB-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-ALB', 'ALB-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-ALB', 'Huntington Disease-evidence-Nerve Degeneration', 'Huntington Disease-recapitulate-HTT', 'INS-increase-Chemical and Drug Induced Liver Injury', 'FOXO3-ascertained-Death', 'Pneumococcal Infections-investigate-Pneumonia', 'Pneumococcal Infections-investigate-Respiratory Tract Diseases', 'Polysaccharides-investigate-Pneumonia', 'Polysaccharides-investigate-Respiratory Tract Diseases', 'Death-be higher in-Arthritis, Rheumatoid', 'Adalimumab-compare-Diabetes Mellitus', 'IFI16-potentiate-Heart Arrest', 'Mitochondrial Diseases-induce-Carcinoma, Hepatocellular', 'Hyperkalemia-associated-Drug-Related Side Effects and Adverse Reactions', 'Drug-Related Side Effects and Adverse Reactions-associated-Hyperkalemia', 'Hyperkalemia-associated-Acute Kidney Injury', 'Acute Kidney Injury-associated-Hyperkalemia', 'Arrhythmias, Cardiac-associated-Drug-Related Side Effects and Adverse Reactions', 'Drug-Related Side Effects and Adverse Reactions-associated-Arrhythmias, Cardiac', 'Arrhythmias, Cardiac-associated-Acute Kidney Injury', 'Acute Kidney Injury-associated-Arrhythmias, Cardiac', 'Hyperkalemia-associated-Digoxin', 'Digoxin-associated-Hyperkalemia', 'Arrhythmias, Cardiac-associated-Digoxin', 'Digoxin-associated-Arrhythmias, Cardiac', 'Blood Protein Disorders-express-Dementia', 'Glucose-result-INS', 'Glucose-take-INS', 'Triglycerides-result-INS', 'Glucose-result-Atherosclerosis', 'Triglycerides-result-Atherosclerosis', 'Pulmonary Disease, Chronic Obstructive-be with-Muscular Atrophy', 'Sleep Wake Disorders-likelihood of-Alzheimer Disease', 'NRGN-differentiate-Alzheimer Disease', 'NRGN-correlate-Alzheimer Disease', 'GDF15-implicated-Cardiovascular Diseases', 'GDF15-implicated-Diabetes Mellitus', 'NRGN-complement-Alzheimer Disease', 'Cerebral Infarction-target-NAMPT', 'Brain Injuries, Traumatic-target-NAMPT', 'Neurodegenerative Diseases-target-NAMPT', 'rs5848-associated-Atrophy', 'Atrophy-associated-rs5848', 'Bleomycin-affect-Fibrosis', 'Glucose-show-Diabetes Mellitus, Type 2', 'HTR2B-be in-Infarction', 'Seizures-fit-Alzheimer Disease', 'HTR2B-aggravate-Stroke', 'Alzheimer Disease-associated-Metabolic Diseases', 'Metabolic Diseases-associated-Alzheimer Disease', 'APOE-fit-Seizures', 'Hip Fractures-result-Bone Neoplasms', 'APOE-integrate-Alzheimer Disease', 'CRP-be In-Intracranial Hemorrhages', 'Neoplasms-observed-Breast Neoplasms', 'Neoplasms-exhibit-SOD2', 'SOD2-observed-Breast Neoplasms', 'rs143624519-increase-MAPT', 'MAPT-increase-Tauopathies', 'MAPT-increase-Alzheimer Disease', 'rs143624519-increase-Tauopathies', 'Fasciculation-mediate-Obesity', 'Fasciculation-mediate-Diabetes Mellitus', 'INS-be in-Fasciculation', 'INS-mediate-Obesity', 'INS-mediate-Diabetes Mellitus', 'Central Nervous System Diseases-impair-Hypothalamic Neoplasms', 'Central Nervous System Diseases-dysregulate-Chronobiology Disorders', 'Central Nervous System Diseases-impair-Diabetes Mellitus', 'Hypothalamic Neoplasms-dysregulate-Chronobiology Disorders', 'Hypothalamic Neoplasms-result-Diabetes Mellitus', 'Chronobiology Disorders-result-Diabetes Mellitus', 'INS-dysregulate-Chronobiology Disorders', 'MT2A-overexpress-Drug-Related Side Effects and Adverse Reactions', 'Hypoxia-analysed-Obesity', 'Fatty Acids-provide-Glucose', 'Glucose-revert-Back Pain', 'Hypoxia-analysed-Hypertension', 'Glucose-revert-Heart Failure', 'Fatty Acids-revert-Back Pain', 'Fatty Acids-revert-Heart Failure', 'Glucose-analysed-Obesity', 'Glucose-analysed-Hypertension', 'INS-fall-Cardiac Output, Low', 'Inflammation-regarded-Obesity', 'Inflammation-regarded-Atherosclerosis', 'Inflammation-regarded-INS', 'Calcinosis-be in-Renal Insufficiency, Chronic', 'Neoplasms-affect-Endometrial Neoplasms', 'Neoplasms-affect-Prostatic Neoplasms', 'INHBE-affect-Endometrial Neoplasms', 'INHBE-affect-Neoplasms', 'INHBE-affect-Prostatic Neoplasms', 'SIRT1-evaluated-Neoplasms', 'SIRT1-play role in-Metabolic Diseases', 'SIRT1-considered-Neurodegenerative Diseases', 'SIRT1-considered-Neoplasms', 'SIRT1-play-Neoplasms', 'PRL-associated-Cross Infection', 'Cross Infection-associated-PRL', 'Denosumab-indicated-Osteoporosis', 'Denosumab-indicated-Neoplasm Metastasis', 'Plaque, Amyloid-include-Alzheimer Disease', 'Neoplasm Metastasis-associated-Neoplasms', 'Neoplasms-associated-Neoplasm Metastasis', 'DLX2-required-Neoplasms', 'DLX2-associated-Neoplasm Metastasis', 'Neoplasm Metastasis-associated-DLX2', 'Hypercholesterolemia-knew-Dyslipidemias', 'Hypercholesterolemia-knew-Cardiovascular Diseases', 'DLX2-associated-Neoplasms', 'Neoplasms-associated-DLX2', 'Infections-be in-Arthritis, Rheumatoid', 'Dyslipidemias-related-Osteoarthritis', 'Dyslipidemias-appear-Osteoarthritis', 'Hypertension-related-Osteoarthritis', 'Hypertension-appear-Osteoarthritis', 'Triglycerides-appear-Osteoarthritis', 'Diabetes Mellitus-associated-PTH', 'PTH-associated-Diabetes Mellitus', 'Crohn Disease-defined-Inflammation', 'Neoplasms-implicate-Cardiovascular Diseases', 'Neoplasms-implicate-Metabolic Diseases', 'Neoplasms-reactivate-LIN28A', 'Alzheimer Disease-implicated-Death', 'Alzheimer Disease-implicated-INS', 'AHR-promote-Atherosclerosis', 'AHR-promote-Aneurysm', 'SHH-indicate-Erectile Dysfunction', 'SHH-indicate-Diabetes Mellitus', 'SHH-reduce-Diabetes Mellitus', 'Diabetes Mellitus-define-Kidney Diseases', 'Glucose-estimated-CST3', 'Diabetes Mellitus-estimated-CST3', 'Kidney Diseases-estimated-CST3', 'REST-lead to-Abnormalities, Drug-Induced', 'Seizures-pick-Niemann-Pick Disease, Type C', 'Valproic Acid-rescue-Seizures', 'Valproic Acid-pick-Niemann-Pick Disease, Type C', 'GGH-be with-Neoplasms', 'ZMPSTE24-recapitulate-Inflammation', 'ZMPSTE24-recapitulate-Calcinosis', 'GGH-associated-Neoplasms', 'Neoplasms-associated-GGH', 'ZMPSTE24-decrease-Inflammation', 'ZMPSTE24-decrease-Calcinosis', 'Metabolic Syndrome-characterized-Hypertension', 'Metabolic Syndrome-characterized-Obesity, Abdominal', 'EPO-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-EPO', 'Neoplasms-abrogated-Myeloproliferative Disorders', 'Neoplasms-abrogated-ZFAND2B', 'Psychomotor Agitation-treat-Psychoses, Substance-Induced', 'ZFAND2B-abrogated-Myeloproliferative Disorders', 'Psychomotor Agitation-treat-Dementia', 'Psychoses, Substance-Induced-treat-Dementia', 'Valproic Acid-favored-Psychomotor Agitation', 'Valproic Acid-manage-Psychomotor Agitation', 'Valproic Acid-treat-Psychoses, Substance-Induced', 'Valproic Acid-treat-Dementia', 'RECQL4-cause-Rothmund-Thomson Syndrome', 'RECQL4-promoting in-Breast Neoplasms', 'Communicable Diseases-associated-Neoplasms', 'Neoplasms-associated-Communicable Diseases', 'WRN-lead-Werner Syndrome', 'Neoplasms-considered-Breast Neoplasms', 'WRN-lead-Communicable Diseases', 'RECQL4-considered-Neoplasms', 'WRN-lead-Neoplasms', 'RECQL4-considered-Breast Neoplasms', 'PTH-associated-Neoplasms', 'Neoplasms-associated-PTH', 'Alzheimer Disease-associated-Glucose', 'Glucose-associated-Alzheimer Disease', 'PRKAA2-valid approach for-Neurologic Manifestations', 'PRKAA2-protect-Neurologic Manifestations', 'PRKAA2-be compensatory response in-Huntington Disease', 'PRKAA2-protect-Huntington Disease', 'PNPLA6-cause-Neurodegenerative Diseases', 'Retinal Degeneration-rescue-Neurodegenerative Diseases', 'PNPLA6-occur-Retinal Degeneration', 'PNPLA6-rescue-Neurodegenerative Diseases', 'PNPLA6-cause-Spastic Paraplegia, Hereditary', 'PNPLA6-cause-Laurence-Moon Syndrome', 'Anemia-treat-Kidney Failure, Chronic', 'Anemia-treat-Renal Insufficiency, Chronic', 'EPO-used-Anemia', 'NFKB1-target-Inflammation', 'NFKB1-target-Neoplasms', 'Hypoglycemia-found-INS', 'NR3C2-contribute-Cerebrovascular Disorders', 'NR3C2-contribute-Cardiovascular Diseases', 'ERBB2-associated-Neoplasms', 'Neoplasms-associated-ERBB2', 'Stroke-help-Pneumonia, Aspiration', 'Stroke-avoid-Pneumonia, Aspiration', 'Glycosaminoglycans-help-Stroke', 'Glycosaminoglycans-avoid-Pneumonia, Aspiration', 'Arteriolosclerosis-associated-Sclerosis', 'Sclerosis-associated-Arteriolosclerosis', 'Fractures, Bone-linked-Renal Insufficiency, Chronic', 'Arteriolosclerosis-associated-ABCC9', 'ABCC9-associated-Arteriolosclerosis', 'Diabetes Mellitus-accumulate-Inflammation', 'Diabetes Mellitus-accumulate-Obesity', 'Diabetes Mellitus-derived-Glucose', 'Glucose-accumulate-Inflammation', 'Glucose-accumulate-Obesity', 'Atrophy-increased-Diabetes Mellitus', 'Diabetes Mellitus-find-Muscular Disorders, Atrophic', 'Muscular Atrophy-increased-Diabetes Mellitus', 'Diabetes Mellitus-find-PRKAB1', 'PRKAB1-increased-Diabetes Mellitus', 'Heart Arrest-prevent-Atherosclerosis', 'HSPD1-prevent-Atherosclerosis', 'Hypoglycemia-be with-Coma', 'Dementia-receive-INS', 'INS-receive-Diabetes Mellitus, Type 2', 'Diabetes Mellitus-be with-INS', 'INS-initiate-Weight Gain', 'INS-initiate-Hypoglycemia', 'Obesity-use-Sarcopenia', 'Obesity-defined-Cholesterol', 'Cholesterol-defined-Obesity', 'Neoplasms-be in-Prostatic Neoplasms', 'ALB-measure-Stroke', 'GAB1-reduced-Cardiomyopathy, Dilated', 'GAB1-reduced-Myocarditis', 'Diabetes Mellitus-correlate-Cerebrovascular Disorders', 'Acute Kidney Injury-include-Cardiac Output, Low', 'Acute Kidney Injury-include-Oliguria', 'Acute Kidney Injury-include-Hyperglycemia', 'Acute Kidney Injury-include-ALB', 'Carcinoma, Hepatocellular-work-Neoplasms', 'KL-inhibit-Carcinoma, Hepatocellular', 'KL-work as-Neoplasms', 'KL-work in-Neoplasms', 'Mitochondrial Diseases-reproduce-Alzheimer Disease', 'Reperfusion Injury-avoid-Coronary Artery Disease', 'SIRT1-protect-Reperfusion Injury', 'SIRT1-avoid-Coronary Artery Disease', 'Breast Neoplasms-be with-Neoplasms', 'Breast Neoplasms-lack-WRAP53', 'Neoplasms-lack-WRAP53', 'NFE2L2-tested-Kidney Diseases', 'NFE2L2-tested-Alzheimer Disease', 'Diabetes Mellitus-focused-INS', 'INS-be stepp stone for-Diabetes Mellitus', 'Alzheimer Disease-mediate-Dementia', 'APOE-mediate-Dementia', 'NFE2L2-include-Diabetes Mellitus', 'APOE-confer-Atherosclerosis', 'APOE-confer-Alzheimer Disease', 'Metabolic Syndrome-identified-Diabetes Mellitus', 'KL-play role in-Inflammation', 'KL-play-Pulmonary Disease, Chronic Obstructive', 'Stomach Neoplasms-used-Infections', 'Stomach Neoplasms-undergo-ATP4A', 'Infections-undergo-ATP4A', 'Endometrial Neoplasms-downregulated-SIRT1', 'SIRT1-downregulated-Obesity', 'Triglycerides-associated-Atrial Fibrillation', 'Atrial Fibrillation-associated-Triglycerides', 'Valproic Acid-associated-Myocardial Infarction', 'Myocardial Infarction-associated-Valproic Acid', 'Valproic Acid-associated-Stroke', 'Stroke-associated-Valproic Acid', 'Prostatic Neoplasms-reduction in-Neoplasms', 'Prostatic Neoplasms-display-Neoplasms', 'Diabetes Mellitus, Type 2-require-INS', 'Disease Progression-require-INS', 'Glycogen-contribute to-Neurodegenerative Diseases', 'CRP-linked-Cardiovascular Diseases', 'CRP-reported-Death', 'Metabolic Syndrome-include-CRP', 'Death-include-CRP', 'Glucose-increasing-Diabetic Neuropathies', 'Glucose-increasing-Diabetes Mellitus, Type 2', 'CDK5-implicated-Alzheimer Disease', 'Calcinosis-trigger-Osteosarcoma', 'Calcinosis-caused-Calcitriol', 'Calcitriol-trigger-Osteosarcoma', 'Hyperlipidemias-require-Diabetes Mellitus', 'Hyperlipidemias-require-Dyslipidemias', 'Hyperlipidemias-associated-Dyslipidemias', 'Dyslipidemias-associated-Hyperlipidemias', 'Hyperlipidemias-associated-Glucose', 'Glucose-associated-Hyperlipidemias', 'Glucose-require-Diabetes Mellitus', 'Reperfusion Injury-lead-Deafness', 'Immunologic Deficiency Syndromes-contribute-Chronic Disease', 'KL-lead-Deafness', 'KL-contribute-Chronic Disease', 'Diabetes Mellitus-receive-Dyskinesias', 'EGFR-associated-Neoplasms', 'Neoplasms-associated-EGFR', 'EGFR-associated-Schistosomiasis', 'Schistosomiasis-associated-EGFR', 'Viremia-suggest-Inflammation', 'CD4-suggest-Inflammation', 'Death-related-Venous Thromboembolism', 'Venous Thromboembolism-compare-Heparin, Low-Molecular-Weight', 'Death-compare-Heparin, Low-Molecular-Weight', 'Werner Syndrome-associate-Neoplasms', 'Neoplasms-associate-Werner Syndrome', 'Genetic Diseases, Inborn-associate-Neoplasms', 'Neoplasms-associate-Genetic Diseases, Inborn', 'WRN-cause-Genetic Diseases, Inborn', 'Neurotoxicity Syndromes-prevent-Alzheimer Disease', 'WRN-associate-Neoplasms', 'Neoplasms-associate-WRN', 'KL-act as-Neoplasms', 'Corneal Diseases-promote-Anophthalmos', 'KL-act in-Carcinoma, Hepatocellular', 'Cyclosporine-promote-Anophthalmos', 'Carcinoma, Hepatocellular-study-KL', 'KL-study-Neoplasms', 'SIRT1-downregulated-Heart Failure', 'Infertility, Female-take-Hirsutism', 'Infertility, Female-take-Galactose', 'SIRT1-compensate-Heart Failure', 'Inflammation-taken-Necrosis', 'SIRT1-implicated-Cardiovascular Diseases', 'Inflammation-taken-IL6', 'Brain Diseases-include-Sclerosis', 'Sleep Wake Disorders-include-Brain Diseases', 'Sclerosis-include-Sleep Wake Disorders', 'Brain Diseases-linked-ABCC9', 'ABCC9-include-Sclerosis', 'ABCC9-include-Sleep Wake Disorders', 'ABCC9-linked-Sleep Wake Disorders', 'Erectile Dysfunction-increase-CRP', 'Prostatic Hyperplasia-increase-CRP', 'NAMPT-modulate-Obesity', 'NAMPT-involved-Obesity', 'NAMPT-involved-Non-alcoholic Fatty Liver Disease', 'NAMPT-influence-Diabetes Mellitus, Type 2', 'NAMPT-influence-Glucose Metabolism Disorders', 'FMR1-associated-Ovarian Diseases', 'Ovarian Diseases-associated-FMR1', 'NAMPT-influence-Inflammation', 'Death-be in-Atherosclerosis', 'TERT-associated-Coronary Artery Disease', 'Coronary Artery Disease-associated-TERT', 'Pulmonary Disease, Chronic Obstructive-associated-Inflammation', 'Inflammation-associated-Pulmonary Disease, Chronic Obstructive', 'KL-be in-Pulmonary Disease, Chronic Obstructive', 'KL-associated-Inflammation', 'Inflammation-associated-KL', 'Neoplasms-observed-Liver Abscess, Pyogenic', 'Fever-observed-Liver Abscess, Pyogenic', 'CRP-observed-Liver Abscess, Pyogenic', 'VEGFA-correlated-Bone Marrow Diseases', 'VEGFA-correlated-Hodgkin Disease', 'Olive Oil-associated-Chronic Disease', 'Chronic Disease-associated-Olive Oil', 'Cardiovascular Diseases-be lead cause worldwide of-Death', 'Aneurysm-associated-Vasospasm, Intracranial', 'Vasospasm, Intracranial-associated-Aneurysm', 'Aneurysm-show-Vasospasm, Intracranial', 'Inflammation-be major contributor to-Renal Insufficiency, Chronic', 'POLD1-reported-Hypoadrenocorticism, Familial', 'POLD1-reported-Deafness', 'Osteoporosis-stimulate-Bone Neoplasms', 'Teriparatide-stimulate-Bone Neoplasms', 'GADD45G-decrease in-Neoplasms', 'GADD45G-decrease from-Carcinoma, Hepatocellular', 'AHSG-be higher in-Sarcopenia', 'AHSG-associated-Hypotension', 'Hypotension-associated-AHSG', 'AHSG-do-Sarcopenia', 'LCN2-emerge in-Multiple Sclerosis', 'Neurodegenerative Diseases-increased-Alzheimer Disease', 'VGF-increased-Alzheimer Disease', 'Hypertension-modify-Alzheimer Disease', 'Hypertension-modify-CISD2', 'Hypertension-modify-rs223331', 'SIRT3-induced-SNORD87', 'SIRT3-demonstrate-SNORD87', 'Stomach Neoplasms-compare-Neoplasms', 'SIRT3-induced-Neoplasms', 'Neoplasms-detected-Stomach Neoplasms', 'SIRT3-induced-Colorectal Neoplasms', 'SIRT3-induced-Glioblastoma', 'SIRT3-demonstrate-Glioblastoma', 'SIRT3-induced-Breast Neoplasms', 'SNORD87-include-Neoplasms', 'SIRT3-increased-Stomach Neoplasms', 'SIRT3-increased-Neoplasms', 'SIRT3-linked-Neoplasms', 'SIRT3-detected-Stomach Neoplasms', 'SIRT3-linked-Stomach Neoplasms', 'SIRT3-provide effects in-Cardiomyopathy, Hypertrophic', 'ABCC9-associated-Sclerosis', 'Sclerosis-associated-ABCC9', 'SIRT3-provide-Cardiomyopathies', 'ABCC9-associated-Brain Diseases', 'Brain Diseases-associated-ABCC9', 'ABCC9-associated-Alzheimer Disease', 'Alzheimer Disease-associated-ABCC9', 'SIRT6-ameliorate-Cardiomyopathy, Hypertrophic', 'rs1187120-be in-DNMT3A', 'Immunologic Deficiency Syndromes-result-Neurologic Manifestations', 'Immunologic Deficiency Syndromes-lead to-Cartilage Diseases', 'Neurologic Manifestations-lead-Cartilage Diseases', 'SOD2-result-Neurologic Manifestations', 'SOD2-lead to-Cartilage Diseases', 'Neuromuscular Junction Diseases-associated-Muscular Atrophy', 'Muscular Atrophy-associated-Neuromuscular Junction Diseases', 'Neuromuscular Junction Diseases-characterize-Sarcopenia', 'Neoplasms-associated-Muscular Atrophy', 'Muscular Atrophy-associated-Neoplasms', 'Neoplasms-characterize-Sarcopenia', 'Muscular Atrophy-characterize-Sarcopenia', 'AGRN-associated-Muscular Atrophy', 'Muscular Atrophy-associated-AGRN', 'Pulmonary Disease, Chronic Obstructive-measured-Hypoxia', 'AGRN-characterize-Sarcopenia', 'Niemann-Pick Disease, Type A-associated-Mitochondrial Diseases', 'Mitochondrial Diseases-associated-Niemann-Pick Disease, Type A', 'Mitochondrial Diseases-associated-Ceramides', 'Ceramides-associated-Mitochondrial Diseases', 'Diabetes Mellitus, Type 2-develop-Obesity', 'Diabetes Mellitus, Type 2-develop-INS', 'Neoplasms-for marker be-Diabetes Mellitus', 'CLU-make-Neoplasms', 'CLU-make-Cardiovascular Diseases', 'CLU-make-Diabetes Mellitus', 'Metabolic Diseases-aggravate-Alzheimer Disease', 'PRKAB1-be common defect in-Metabolic Diseases', 'PRKAB1-aggravate-Alzheimer Disease', 'Glucose-detect-Diabetes Mellitus', 'Glucose-detect-Prediabetic State', 'Glucose-decreased-Obesity', 'Glucose-decreased-Diabetes Mellitus', 'INS-improve-Stroke', 'Glucose Metabolism Disorders-be in-Diabetes Mellitus', 'Necrosis-predict-Death', 'TNFRSF11B-predict-Death', 'INS-involved-Immunologic Deficiency Syndromes', 'Neurologic Manifestations-promote-Inflammation', 'Neurologic Manifestations-promote-Atherosclerosis', 'PON1-contribute-Neurologic Manifestations', 'PON1-promote-Inflammation', 'PON1-contribute-Atherosclerosis', 'Infections-destroy-Neoplasms', 'PON1-prevent-Infections', 'PON1-contribute-Neoplasms', 'Neoplasms-be major regulator of-Heart Arrest', 'TP53-be major regulator of-Heart Arrest', 'Multiple Sclerosis-reflect-Neurodegenerative Diseases', 'Neuromuscular Junction Diseases-underlie-Sarcopenia', 'TNNT1-underlie-Sarcopenia', 'PARP1-linked-Neoplasms', 'PARP1-linked-Brain Injuries, Traumatic', 'PARP1-linked-Atherosclerosis', 'PARP1-linked-Diabetes Mellitus', 'CRP-defined-Inflammation', 'PARP1-linked-Inflammation', 'Fractures, Bone-improve-Kidney Diseases', 'LCN2-improve-Fractures, Bone', 'LCN2-improve-Kidney Diseases', 'Coronary Artery Disease-follow-Heart Failure', 'Cardiovascular Diseases-follow-Heart Failure', 'rs1799895-identified-Heart Failure', 'rs1799895-follow-Coronary Artery Disease', 'rs1799895-identified-Coronary Artery Disease', 'rs1799895-follow-Cardiovascular Diseases', 'rs1799895-identified-Cardiovascular Diseases', 'Constipation-increase-Olfaction Disorders', 'Constipation-increase-Parkinson Disease', 'Constipation-increase-rs11931074', 'rs11931074-increase-Olfaction Disorders', 'rs11931074-increase-Parkinson Disease', 'Glucose-remain-Cardiovascular Diseases', 'PPIA-advanced-Kidney Diseases', 'Infliximab-keep-Neurodegenerative Diseases', 'Infliximab-keep-Nervous System Diseases', 'Infliximab-keep-Alzheimer Disease', 'POSTN-be marker of-Kidney Diseases', 'POSTN-related to-Acute Kidney Injury', 'POSTN-related in-Renal Insufficiency, Chronic', 'POSTN-be elevated in-Albuminuria', 'POSTN-correlate-Albuminuria', 'VSNL1-demonstrate-Nerve Degeneration', 'VSNL1-demonstrate-Alzheimer Disease', 'MAPT-be in-Alzheimer Disease', 'Genetic Diseases, Inborn-characterized-Nervous System Diseases', 'Nerve Degeneration-exhibit-Neurodegenerative Diseases', 'Neurodegenerative Diseases-exhibit-Brain Injuries, Traumatic', 'Neurodegenerative Diseases-exhibit-Ischemia', 'Nerve Degeneration-exhibit-Brain Injuries, Traumatic', 'Nerve Degeneration-exhibit-Ischemia', 'Neurodegenerative Diseases-exhibit-TNF', 'Nerve Degeneration-exhibit-TNF', 'Lipopolysaccharides-found-Sepsis', 'Non-alcoholic Fatty Liver Disease-associated-Liver Cirrhosis', 'Liver Cirrhosis-associated-Non-alcoholic Fatty Liver Disease', 'Non-alcoholic Fatty Liver Disease-associated-SLC17A5', 'SLC17A5-associated-Non-alcoholic Fatty Liver Disease', 'Hip Fractures-associated-ALB', 'ALB-associated-Hip Fractures', 'SLC17A5-associated-Liver Cirrhosis', 'Liver Cirrhosis-associated-SLC17A5', 'ALB-associated-Infections', 'Infections-associated-ALB', 'Pneumonia-contribute-Infections', 'TSLP-contribute to-Pneumonia', 'TSLP-contribute upon-Infections', 'TSLP-contribute-Pneumonia', 'TSLP-contribute-Infections', 'Venous Thromboembolism-associated-Neoplasms', 'Neoplasms-associated-Venous Thromboembolism', 'IL10-associated-Venous Thromboembolism', 'Venous Thromboembolism-associated-IL10', 'IL10-associated-Neoplasms', 'Neoplasms-associated-IL10', 'Hypotension-indicate-Diabetes Mellitus', 'Sialic Acids-up-regulated-Liver Diseases', 'VEGFA-implicated-Alzheimer Disease', 'VEGFA-implicated-Neurodegenerative Diseases', 'VEGFA-stave-Neurodegenerative Diseases', 'Diabetes Mellitus-compare-Hypertension', 'Diabetes Mellitus-compare-Enalapril', 'SAR1B-assess-Alzheimer Disease', 'SAR1B-assess-Dementia, Vascular', 'Airway Obstruction-caused-Prostatic Hyperplasia', 'SRD5A2-used-Airway Obstruction', 'SRD5A2-used-Prostatic Hyperplasia', 'SRD5A2-caused-Prostatic Hyperplasia', 'Hypertension-suggest-KL', 'Kidney Diseases-suggest-KL', 'Dementia-experience-Hypoglycemia', 'INS-experience-Hypoglycemia', 'Urinary Retention-coordinate-Alzheimer Disease', 'APOE-complete-Urinary Retention', 'APOE-coordinate-Alzheimer Disease', 'Death-simulate-Alzheimer Disease', 'KL-decrease-Death', 'KL-simulate-Alzheimer Disease', 'KL-counteract-Neurodegenerative Diseases', 'KL-counteract-Alzheimer Disease', 'Fibrosis-captured-EGFR', 'Kidney Failure, Chronic-captured-EGFR', 'Diabetes Mellitus-up-regulated-Parkinson Disease', 'HNF4A-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-HNF4A', 'HNF4A-identify-Parkinson Disease', 'Inflammation-reduce-Neurodegenerative Diseases', 'MAPT-reduce-Inflammation', 'MAPT-reduce-Neurodegenerative Diseases', 'Hypertension-known-Cardiovascular Diseases', 'Hypertension-associated-AMH', 'AMH-associated-Hypertension', 'Cardiovascular Diseases-associated-AMH', 'AMH-associated-Cardiovascular Diseases', 'Cushing Syndrome-present-Hyperparathyroidism, Primary', 'Glucose-implicated-Osteoporosis', 'POMC-present-Hyperparathyroidism, Primary', 'rs2230009-increase-Fractures, Bone', 'rs2230009-increase-Femoral Fractures', 'Neoplasms-associated-CDKN1A', 'CDKN1A-associated-Neoplasms', 'rs138213197-associated-Neoplasms', 'Neoplasms-associated-rs138213197', 'rs138213197-associated-Prostatic Neoplasms', 'Prostatic Neoplasms-associated-rs138213197', 'Kidney Diseases-characterised-TTR', 'Amyloid Neuropathies, Familial-include-Amyloidosis, Familial', 'PIN1-implicated-Neurodegenerative Diseases', 'PIN1-include-Neurodegenerative Diseases', 'PIN1-diminished-Alzheimer Disease', 'PIN1-related-Neurodegenerative Diseases', 'Inflammation-regulate-FGF23', 'Genetic Diseases, Inborn-manifest-Emphysema', 'Genetic Diseases, Inborn-manifest-Liver Cirrhosis', 'SERPINA1-be genetic disease-Emphysema', 'SERPINA1-manifest-Emphysema', 'SERPINA1-manifest-Liver Cirrhosis', 'Fractures, Bone-present-Osteoporosis', 'Teriparatide-improve-Osteoporosis', 'MTOR-deregulated-Metabolic Diseases', 'MTOR-deregulated-Obesity', 'MTOR-deregulated-Diabetes Mellitus', 'MTOR-deregulated-Neoplasms', 'WRN-be in-Carcinoma, Squamous Cell', 'Glucose Intolerance-reduce-Hyperglycemia', 'Inflammation-mediate-Death', 'Nephrosis, Lipoid-follow-CD79A', 'Glomerulosclerosis, Focal Segmental-follow-CD79A', 'CCL18-involved-Aortic Aneurysm, Abdominal', 'Progeria-linked-LMNA', 'KL-decrease-Adenocarcinoma', 'KL-decrease-Fibrosis', 'Aging, Premature-linked-LMNA', 'CERS2-have tumor growth in-Breast Neoplasms', 'CERS2-have tumor growth in-Neoplasms', 'CERS2-provide-Neoplasms', 'Neoplasm Metastasis-inhibit-Breast Neoplasms', 'Cholesterol-followed-Hypertension', 'Cholesterol-followed-Diabetes Mellitus', 'SLC5A2-decrease-Kidney Diseases', 'SLC5A2-increase-Glucose Metabolism Disorders', 'Coronary Artery Disease-become-Diabetes Mellitus', 'Coronary Artery Disease-become-Hypertension', 'Coronary Artery Disease-become-Cholesterol', 'Cockayne Syndrome-characterized-Intellectual Disability', 'Cockayne Syndrome-associated-Intellectual Disability', 'Intellectual Disability-associated-Cockayne Syndrome', 'ERCC6-associated-Cockayne Syndrome', 'Cockayne Syndrome-associated-ERCC6', 'ERCC6-associated-Intellectual Disability', 'Intellectual Disability-associated-ERCC6', 'Neurodegenerative Diseases-generate-Neoplasms', 'Neutropenia-occur-Infections', 'Neutropenia-receive-Rituximab', 'Rituximab-occur-Infections', 'HCRT-linked-Narcolepsy', 'HCRT-linked-Obesity', 'HCRT-be in-Narcolepsy', 'PTH-predict-Death', 'Sleep Apnea, Obstructive-be prevalent in-Diabetes Mellitus, Type 2', 'Hypoxia-be in-Sleep Apnea, Obstructive', 'Hypoxia-increase-Diabetes Mellitus, Type 2', 'Sleep Apnea, Obstructive-increase-Diabetes Mellitus, Type 2', 'CLU-change-Heredodegenerative Disorders, Nervous System', 'Hypoxia-alter-Glucose', 'CLU-contribute-Retinal Degeneration', 'Sleep Apnea, Obstructive-alter-Glucose', 'Glucose-increase-Diabetes Mellitus, Type 2', 'PROM1-epitope of be-Neoplasms', 'Obesity-linked-CRP', 'CRP-be with-Death', 'CRP-increase-Cardiovascular Diseases', 'SNCA-cause-Neurodegenerative Diseases', 'Neurodegenerative Diseases-suggest-Dementia', 'FASTKD2-nominate-Neurodegenerative Diseases', 'FASTKD2-modulate-Neurodegenerative Diseases', 'FASTKD2-suggest-Dementia', 'Neurodegenerative Diseases-contribute-Parkinson Disease', 'Parkinsonian Disorders-prompt-Neurodegenerative Diseases', 'Parkinsonian Disorders-underlie-Neurodegenerative Diseases', 'Parkinsonian Disorders-unmask-Parkinson Disease', 'Neurodegenerative Diseases-unmask-Parkinson Disease', 'Parkinsonian Disorders-unmask-Valproic Acid', 'Neurodegenerative Diseases-unmask-Valproic Acid', 'Valproic Acid-unmask-Parkinson Disease', 'Inflammation-lead-Intracranial Arterial Diseases', 'SIRT1-lead-Intracranial Arterial Diseases', 'Diabetes Mellitus-associated-Niemann-Pick Disease, Type A', 'Niemann-Pick Disease, Type A-associated-Diabetes Mellitus', 'Triglycerides-associated-Niemann-Pick Disease, Type A', 'Niemann-Pick Disease, Type A-associated-Triglycerides', 'Amenorrhea-associated-AMH', 'AMH-associated-Amenorrhea', 'AMH-associated-Weight Loss', 'Weight Loss-associated-AMH', 'NAMPT-up-regulated-Neoplasms', 'NAMPT-up-regulated-Breast Neoplasms', 'Neoplasms-express-Erythroblastosis, Fetal', 'Neoplasms-express-ERG', 'Obesity-explain-Neoplasms', 'Diabetes Mellitus-explain-Neoplasms', 'NAMPT-found-Obesity', 'NAMPT-found-Diabetes Mellitus', 'Infections-encode-MAPT', 'Neoplasms-suggest-Skin Neoplasms', 'Neoplasms-suggest-STK11', 'INS-associate-Cardiovascular Diseases', 'Cardiovascular Diseases-associate-INS', 'INS-associate with-Death', 'Neoplasms-mutated-Colorectal Neoplasms', 'ARID1A-mutated-Neoplasms', 'Weight Loss-play-Carcinoma, Hepatocellular', 'Weight Loss-play-INS', 'SIRT1-inhibit-Fibrosis', 'BRD4-predict-Neoplasms', 'BRD4-predict-Breast Neoplasms', 'Demyelinating Diseases-demyelinate-Neurodegenerative Diseases', 'Demyelinating Diseases-ameliorate-SIRT1', 'Neurodegenerative Diseases-ameliorate-SIRT1', 'Fatty Liver-associated-Obesity', 'Obesity-associated-Fatty Liver', 'Fatty Liver-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-Fatty Liver', 'Diabetes Mellitus-reported-Carcinoma, Hepatocellular', 'Diabetes Mellitus-predispose-Carcinoma, Hepatocellular', 'INS-reported-Carcinoma, Hepatocellular', 'INS-predispose-Carcinoma, Hepatocellular', 'Chemical and Drug Induced Liver Injury-linked-Carcinoma, Hepatocellular', 'Lipid Metabolism Disorders-influence-Carcinoma, Hepatocellular', 'Lipid Metabolism Disorders-influence-Liver Cirrhosis', 'Carcinoma, Hepatocellular-influence-Liver Cirrhosis', 'PNPLA3-influence-Lipid Metabolism Disorders', 'PNPLA3-influence-Carcinoma, Hepatocellular', 'rs738409-influence-Lipid Metabolism Disorders', 'rs738409-influence-Carcinoma, Hepatocellular', 'STUB1-encode-Shock', 'INS-assess-Cardiovascular Diseases', 'INS-assess-Diabetes Mellitus', 'Inflammation-modulate-Diabetes Mellitus', 'Fibrosis-modulate-Diabetes Mellitus', 'Lipid Metabolism Disorders-modulate-Diabetes Mellitus', 'KL-participate-Diabetic Nephropathies', 'KL-modulate-Inflammation', 'KL-modulate-Fibrosis', 'KL-modulate-Lipid Metabolism Disorders', 'KL-participate-Diabetes Mellitus', 'Hypogonadism-display-Diabetes Mellitus', 'Hypogonadism-display-Uveitis', 'STUB1-display-Hypogonadism', 'STUB1-remain-Diabetes Mellitus', 'STUB1-remain-Uveitis', 'STUB1-remain-Colitis, Ulcerative', 'rs690016544-display-Hypogonadism', 'rs690016544-show-Diabetes Mellitus', 'rs690016544-show-Uveitis', 'rs690016544-show-Colitis, Ulcerative', 'Ataxia Telangiectasia-cause-Genetic Diseases, Inborn', 'Genetic Diseases, Inborn-characterized-Cerebellar Diseases', 'Genetic Diseases, Inborn-characterized-Immunologic Deficiency Syndromes', 'Neurodegenerative Diseases-assessed-Inflammation', 'ATM-cause-Genetic Diseases, Inborn', 'ATM-cause-Immunologic Deficiency Syndromes', 'Hypoglycemia-develop-Hypotension, Orthostatic', 'Hypoglycemia-worsened-Dehydration', 'Alzheimer Disease-characterized-Diabetes Mellitus, Type 2', 'Hypotension, Orthostatic-worsened-Dehydration', 'Alzheimer Disease-characterized-IAPP', 'Hypoglycemia-used-INS', 'Urinary Incontinence, Stress-result-BDNF', 'Diabetes Mellitus, Type 2-characterized-IAPP', 'INS-used-Hypotension, Orthostatic', 'Alzheimer Disease-known-IAPP', 'Diabetes Mellitus, Type 2-known-IAPP', 'INS-used-Dehydration', 'NOS3-observe-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-Fatty Acids', 'Fatty Acids-associated-Cardiovascular Diseases', 'CST3-associated-Brain Infarction', 'Brain Infarction-associated-CST3', 'CST3-associated-Atrophy', 'Atrophy-associated-CST3', 'Rituximab-used-Lymphoproliferative Disorders', 'Rituximab-considered-Leukemia, Lymphocytic, Chronic, B-Cell', 'Glutathione-identified-Prostatic Neoplasms', 'Glutathione-identified-Prostatic Hyperplasia', 'Glucose-produced-Adenoma, Liver Cell', 'Glucose-exhibit-Neoplasms', 'Retinal Diseases-characterized-Lipofuscin', 'Neurotoxicity Syndromes-involved-Neurodegenerative Diseases', 'TDO2-implicated-Neurotoxicity Syndromes', 'TDO2-implicated-Neurodegenerative Diseases', 'TDO2-involved-Neurodegenerative Diseases', 'Diabetes Mellitus-assess-CRP', 'Neoplasms-participate-Prostatic Neoplasms', 'KL-participate in-Neoplasms', 'Stroke-influenced-Cholesterol', 'Death-influenced-Cholesterol', 'IRS1-include-Alzheimer Disease', 'IRS1-include-Tauopathies', 'Dementia-linked-Alzheimer Disease', 'IRS1-include-TDP-43 Proteinopathies', 'INS-provoked-Triglycerides', 'INS-associated-Atherosclerosis', 'Atherosclerosis-associated-INS', 'INS-associated-Neoplasms', 'Neoplasms-associated-INS', 'INS-associated-Osteoporosis', 'Osteoporosis-associated-INS', 'SMN1-lead-Neuromuscular Diseases', 'INS-associated-Glucose Metabolism Disorders', 'Glucose Metabolism Disorders-associated-INS', 'Triglycerides-associated-Neoplasms', 'Neoplasms-associated-Triglycerides', 'Triglycerides-associated-Osteoporosis', 'Osteoporosis-associated-Triglycerides', 'Triglycerides-associated-Inflammation', 'Inflammation-associated-Triglycerides', 'Vision Disorders-recommended-CD4', 'Diabetes Mellitus-maintain-Hypotension', 'Diabetes Mellitus-defined-Glucose Intolerance', 'Diabetes Mellitus, Type 2-accelerate-Alzheimer Disease', 'Diabetes Mellitus, Type 2-accelerate-INS', 'Werner Syndrome-cause by-WRN', 'Werner Syndrome-cause-WRN', 'Aging, Premature-cause-WRN', 'HIV Infections-enhance-Infections', 'Diabetes Mellitus-be capable at-Alzheimer Disease', 'Diabetes Mellitus-be capable of-MAPT', 'Parkinson Disease-suffer-Xerostomia', 'GDNF-used-Parkinson Disease', 'GDNF-suffer-Xerostomia', 'Infertility, Female-associated-Aneuploidy', 'Aneuploidy-associated-Infertility, Female', 'FMR1-associated-Aneuploidy', 'Aneuploidy-associated-FMR1', 'Alzheimer Disease-characterized-Nervous System Diseases', 'Dementia-characterized-Nervous System Diseases', 'Alzheimer Disease-composed-MAPT', 'Nervous System Diseases-composed-MAPT', 'Ichthyosis-range-Cockayne Syndrome', 'Ichthyosis-range-Trichothiodystrophy Syndromes', 'ERCC2-associated-Neoplasms', 'Neoplasms-associated-ERCC2', 'ERCC2-associated-Ichthyosis', 'Ichthyosis-associated-ERCC2', 'ERCC2-range-Ichthyosis', 'ERCC2-associated-Cockayne Syndrome', 'Cockayne Syndrome-associated-ERCC2', 'ERCC2-associated-Trichothiodystrophy Syndromes', 'Trichothiodystrophy Syndromes-associated-ERCC2', 'KCNJ10-increased-Demyelinating Diseases', 'KCNJ10-increased-Blister', 'KCNJ10-retained-Multiple Sclerosis', 'Gastritis, Atrophic-associated-Triglycerides', 'Triglycerides-associated-Gastritis, Atrophic', 'KCNJ10-retained-Demyelinating Diseases', 'CRP-reflect-Metabolic Diseases', 'Neoplasms-show expression in-Prostatic Neoplasms', 'Neoplasms-show-Prostatic Neoplasms', 'Neoplasms-show-NR2C2', 'AVP-increase-Death', 'Gangliosides-be important diagnostic markers for-Brain Neoplasms', 'Diabetes Mellitus, Type 2-observed-Alzheimer Disease', 'INS-result-Glucose', 'Fasciculation-associated-Obesity', 'Obesity-associated-Fasciculation', 'Diabetes Mellitus, Type 2-characterized-INS', 'INS-observed-Alzheimer Disease', 'INS-resemble-Alzheimer Disease', 'LEP-associated-Fasciculation', 'Fasciculation-associated-LEP', 'Diabetes Mellitus, Type 2-characterized-Glucose', 'Glucose-result-Alzheimer Disease', 'Glucose-observed-Alzheimer Disease', 'Diabetes Mellitus-considered-Cardiovascular Diseases', 'Cholesterol-considered-Cardiovascular Diseases', 'Dinoprostone-elevated-Neoplasms', 'Dinoprostone-elevated-Infections', 'Neoplasms-promote-Drug-Related Side Effects and Adverse Reactions', 'Dinoprostone-seen-Neoplasms', 'Dinoprostone-associated-HIV Infections', 'HIV Infections-associated-Dinoprostone', 'Brain Diseases-develop-Neurodegenerative Diseases', 'MTOR-contribute-Brain Diseases', 'MTOR-contribute-Neurodegenerative Diseases', 'MTOR-develop-Neurodegenerative Diseases', 'Neurologic Manifestations-known-ABCG2', 'Growth Disorders-result-PCNA', 'Growth Disorders-include-PCNA', 'Hearing Loss-result-PCNA', 'Hearing Loss-include-PCNA', 'Telangiectasis-result-PCNA', 'Telangiectasis-include-PCNA', 'Neurodegenerative Diseases-result-PCNA', 'Neurodegenerative Diseases-include-PCNA', 'KL-have potential-Brain Neoplasms', 'KL-downregulated-Brain Neoplasms', 'KL-downregulated-Neoplasms', 'Growth Disorders-result-rs369958038', 'Hearing Loss-result-rs369958038', 'Telangiectasis-result-rs369958038', 'Neurodegenerative Diseases-result-rs369958038', 'MTOR-play role in-Alzheimer Disease', 'MTOR-associated-Alzheimer Disease', 'Alzheimer Disease-associated-MTOR', 'GRN-modulated-Inflammation', 'Renal Insufficiency, Chronic-show-Bone Diseases, Metabolic', 'Infections-exhibit-TERT', 'Hepatitis B-exhibit-TERT', 'Diabetes Mellitus-divided-Myotonic Dystrophy', 'SLC2A9-induce-Neoplasms', 'Diabetes Mellitus-divided-Diabetes Mellitus, Type 2', 'Diabetes Mellitus-divided-Glucose', 'Dyslipidemias-cause-Chemical and Drug Induced Liver Injury', 'INS-cause-Chemical and Drug Induced Liver Injury', 'PARP1-mediate-Progeria', 'KL-used-Neoplasms', 'KL-assess-Neoplasms', 'KL-assess-Colorectal Neoplasms', 'MIR34A-implicated-Neoplasms', 'MIR34A-implicated-Brain Diseases', 'KL-decreased-Neoplasms', 'KL-associated-Inert Gas Narcosis', 'Inert Gas Narcosis-associated-KL', 'MIR34A-implicated-Osteoporosis', 'MIR34A-implicated-Cardiovascular Diseases', 'Inflammation-result-Neurodegenerative Diseases', 'CLU-affect-Inflammation', 'CLU-result-Neurodegenerative Diseases', 'Sodium Dodecyl Sulfate-be part of-Cerebrovascular Disorders', 'Brain Edema-result-Neurodegenerative Diseases', 'Brain Edema-contribute-Neurodegenerative Diseases', 'Neoplasms-classify-Neoplasm Invasiveness', 'Breast Neoplasms-classify-Neoplasm Invasiveness', 'Neoplasms-use-ERBB2', 'Breast Neoplasms-use-ERBB2', 'Neoplasm Invasiveness-classify-ERBB2', 'ENG-play-Telangiectasia, Hereditary Hemorrhagic', 'ENG-play-Pre-Eclampsia', 'Dementia-related-Alzheimer Disease', 'ENG-play-Neoplasms', 'Ascites-associated-Death', 'Death-associated-Ascites', 'Stroke-develop-Diabetes Mellitus', 'Alzheimer Disease-promote-Nerve Degeneration', 'RCAN1-promote-Nerve Degeneration', 'Fatigue-prevent-Neoplasms', 'CEACAM3-decrease-Fatigue', 'Dyspnea-include-Respiratory Insufficiency', 'Dyspnea-decrease-Venlafaxine Hydrochloride', 'Death-risk of be-Sarcopenia', 'Death-risk of be-H19', 'Sarcopenia-define-Ataxia', 'Sarcopenia-define-H19', 'Hyperlipoproteinemia Type II-associated-Psychomotor Disorders', 'Psychomotor Disorders-associated-Hyperlipoproteinemia Type II', 'Cholesterol-associated-Psychomotor Disorders', 'Psychomotor Disorders-associated-Cholesterol', 'Neoplasms-divided-Sarcoma', 'Neoplasms-divided-Carcinoma, Squamous Cell', 'Neoplasms-divided-TP63', 'Sarcoma-subdivided-TP63', 'Muscular Diseases-lead-Muscle Weakness', 'Muscular Diseases-lead-Atrophy', 'Muscle Weakness-lead-Sarcopenia', 'Atrophy-lead-Sarcopenia', 'N-Acetylneuraminic Acid-in changes be-Muscular Diseases', 'N-Acetylneuraminic Acid-lead-Muscle Weakness', 'N-Acetylneuraminic Acid-lead-Atrophy', 'Bone Neoplasms-induced-Anorexia', 'OXT-potentiate-Bone Neoplasms', 'OXT-induced-Anorexia', 'Hypoxia-improve-Memory Disorders', 'NFE2L2-increase-Hypoxia', 'NFE2L2-improve-Memory Disorders', 'GCK-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-GCK', 'Periodontitis-include-Alzheimer Disease', 'C1QA-include-Alzheimer Disease', 'Periodontitis-in component be-C1QA', 'Alzheimer Disease-use-Periodontitis', 'C1QA-belong-Alzheimer Disease', 'Acute Kidney Injury-associated-Hematologic Diseases', 'Hematologic Diseases-associated-Acute Kidney Injury', 'CDKN2A-associated-Hematologic Diseases', 'Hematologic Diseases-associated-CDKN2A', 'Neoplasms-exert-Drug-Related Side Effects and Adverse Reactions', 'APOE-be in-Alzheimer Disease', 'Metabolic Syndrome-estimated-Diabetes Mellitus', 'Drug-Related Side Effects and Adverse Reactions-related-Bevacizumab', 'Metabolic Syndrome-estimated-Cholesterol', 'Dementia, Vascular-cases with-Dementia', 'Diabetes Mellitus, Type 2-defined-INS', 'Obesity-defined-INS', 'Diabetes Mellitus, Type 2-defined-Glucose', 'Glucose-defined-Obesity', 'Erectile Dysfunction-remain after-Hypertension', 'Erectile Dysfunction-associate-Hypertension', 'Hypertension-associate-Erectile Dysfunction', 'Erectile Dysfunction-associate-Cholesterol', 'Cholesterol-associate-Erectile Dysfunction', 'Nervous System Diseases-comprise-Genetic Diseases, Inborn', 'Nervous System Diseases-lead-Genetic Diseases, Inborn', 'Nervous System Diseases-comprise-Paralysis', 'Diarrhea-related-Palivizumab', 'Bronchitis-related-Palivizumab', 'Eczema-related-Palivizumab', 'Nervous System Diseases-comprise-PMP22', 'Nervous System Diseases-related-PMP22', 'PMP22-comprise-Genetic Diseases, Inborn', 'PMP22-lead-Genetic Diseases, Inborn', 'PMP22-comprise-Paralysis', 'GLO1-linked-Obesity', 'GLO1-linked-Diabetes Mellitus', 'LEP-be in-Obesity', 'GLO1-linked-Renal Insufficiency, Chronic', 'GLO1-linked-Cardiovascular Diseases', 'GLO1-linked-Fraser Syndrome', 'GLO1-linked-Neoplasms', 'Dementia-correlate with-BDNF', 'Diabetes Mellitus-correlate with-BDNF', 'Diabetes Mellitus-associated-BDNF', 'BDNF-associated-Diabetes Mellitus', 'Ascorbic Acid-reduce-Colorectal Neoplasms', 'Ascorbic Acid-reduce-Death', 'Diabetes Mellitus-induce-INS', 'Atherosclerosis-induce-INS', 'Cardiovascular Diseases-induce-INS', 'APOD-be elevated in-Nervous System Diseases', 'APOD-elevated-Stroke', 'APOD-prove-Inflammation', 'APOD-prove-Nervous System Diseases', 'Vision Disorders-associated-Delirium', 'Delirium-associated-Vision Disorders', 'ALB-associated-Delirium', 'Delirium-associated-ALB', 'Ghrelin-be discordant-Back Pain', 'Denosumab-report-Femoral Fractures', 'Denosumab-report-Bisphosphonate-Associated Osteonecrosis of the Jaw', 'Denosumab-report-Cellulitis', 'Genetic Diseases, Inborn-caused-LMNA', 'Neurodegenerative Diseases-seem-Inflammation', 'BDNF-reflect-Neurodegenerative Diseases', 'APOE-associated-Atherosclerosis', 'Atherosclerosis-associated-APOE', 'INS-protect-Diabetes Mellitus', 'BDNF-seem-Inflammation', 'Inflammation-include-Cardiovascular Diseases', 'Sugars-include-Cardiovascular Diseases', 'Alzheimer Disease-act-SIRT1', 'Pulmonary Disease, Chronic Obstructive-induce-Emphysematous Cholecystitis', 'Pulmonary Disease, Chronic Obstructive-induce-Hypertension, Pulmonary', 'Pulmonary Disease, Chronic Obstructive-utilize-SFTPC', 'SIRT7-associate-Neoplasms', 'Neoplasms-associate-SIRT7', 'PIN1-associated-Neoplasms', 'Neoplasms-associated-PIN1', 'PIN1-associated-Alzheimer Disease', 'Alzheimer Disease-associated-PIN1', 'Diabetes Mellitus, Type 2-observed-Nerve Degeneration', 'Neurodegenerative Diseases-observed-Nerve Degeneration', 'Alzheimer Disease-observed-Nerve Degeneration', 'INS-observed-Diabetes Mellitus, Type 2', 'INS-observed-Neurodegenerative Diseases', 'WWOX-encode-Neoplasms', 'WWOX-altered-Neoplasms', 'PADI1-link-Neurodegenerative Diseases', 'PADI1-link-Alzheimer Disease', 'PADI1-link-Parkinson Disease', 'Melanoma-indicate-BRAF', 'Neoplasms-reserved-Drug-Related Side Effects and Adverse Reactions', 'EGFR-offer-Drug-Related Side Effects and Adverse Reactions', 'Metabolic Diseases-associated-Dementia', 'Dementia-associated-Metabolic Diseases', 'Obesity-evaluated-Metabolic Syndrome', 'Obesity-evaluated-INS', 'Ghrelin-decreased-Obesity', 'CST3-associated-Glycogen Storage Disease Type II', 'Glycogen Storage Disease Type II-associated-CST3', 'CST3-associated-Alzheimer Disease', 'Alzheimer Disease-associated-CST3', 'Acute Pain-relieve-Prostaglandins', 'Hypertension-determined-Diabetes Mellitus', 'Carotid Artery Diseases-be in-Diabetes Mellitus', 'Carotid Artery Diseases-determined-Diabetes Mellitus', 'Hypertension-determined-Carotid Artery Diseases', 'Hypoglycemia-associated-Canagliflozin', 'Canagliflozin-associated-Hypoglycemia', 'Cholesterol-determined-Diabetes Mellitus', 'Cholesterol-determined-Carotid Artery Diseases', 'TNFRSF11B-associated-Death', 'Death-associated-TNFRSF11B', 'Hyperkalemia-occur-Renal Insufficiency, Chronic', 'Hyperkalemia-use-Canagliflozin', 'Canagliflozin-use-Renal Insufficiency, Chronic', 'Ulcer-main symptoms of be-Pain', 'SIRT6-regulate-Glucose Metabolism Disorders', 'SIRT6-impact-Diabetes Mellitus', 'SOD1-represent-Alzheimer Disease', 'SIRT6-impact-Obesity', 'SIRT6-impact-Heart Diseases', 'SIRT6-impact-Neoplasms', 'Cholecalciferol-decrease-Neoplasms', 'Hemorrhage-contribute-Death', 'F8-contribute-Death', 'Abnormalities, Drug-Induced-associated-Alzheimer Disease', 'Alzheimer Disease-associated-Abnormalities, Drug-Induced', 'Infliximab-cause-Abnormalities, Drug-Induced', 'Infliximab-associated-Alzheimer Disease', 'Alzheimer Disease-associated-Infliximab', 'APOE-associated-Ventricular Fibrillation', 'Ventricular Fibrillation-associated-APOE', 'MAPT-contribute-Alzheimer Disease', 'Neurologic Manifestations-contribute-Cardiovascular Diseases', 'Neurologic Manifestations-contribute-Diabetes Mellitus', 'Neurologic Manifestations-contribute-Stroke', 'Neurologic Manifestations-contribute-Neoplasms', 'Hypertension-remain-Atrial Fibrillation', 'Stroke-remain-Atrial Fibrillation', 'Heart Failure-remain-Atrial Fibrillation', 'ALDH2-contribute-Cardiovascular Diseases', 'Neurologic Manifestations-associated-Fanconi Anemia', 'Fanconi Anemia-associated-Neurologic Manifestations', 'ALDH2-contribute-Diabetes Mellitus', 'Neurologic Manifestations-associated-Pain', 'Pain-associated-Neurologic Manifestations', 'ALDH2-contribute-Neurodegenerative Diseases', 'Neurologic Manifestations-associated-Osteoporosis', 'Osteoporosis-associated-Neurologic Manifestations', 'rs10930201-associated-Nervous System Diseases', 'Nervous System Diseases-associated-rs10930201', 'ALDH2-contribute-Stroke', 'ALDH2-associated-Fanconi Anemia', 'Fanconi Anemia-associated-ALDH2', 'ALDH2-associated-Pain', 'Pain-associated-ALDH2', 'ALDH2-contribute-Neoplasms', 'ALDH2-associated-Osteoporosis', 'Osteoporosis-associated-ALDH2', 'Drug-Related Side Effects and Adverse Reactions-include-Drug Hypersensitivity', 'Drug-Related Side Effects and Adverse Reactions-include-Trastuzumab', 'Drug Hypersensitivity-include-Trastuzumab', 'INS-improve-Alzheimer Disease', 'Diabetes Mellitus-use-Hypertension', 'Diabetes Mellitus-confirmed-Blood Glucose', 'Diabetes Mellitus-use-Blood Glucose', 'Trauma, Nervous System-improve-Stroke', 'Brain Ischemia-improve-Stroke', 'Trauma, Nervous System-improve-SIRT1', 'Brain Ischemia-improve-SIRT1', 'SIRT1-improve-Stroke', 'Diabetes Mellitus, Type 2-be with-Metabolic Syndrome', 'INPPL1-associated-Diabetes Mellitus, Type 2', 'Diabetes Mellitus, Type 2-associated-INPPL1', 'INPPL1-associated-Metabolic Syndrome', 'Metabolic Syndrome-associated-INPPL1', 'MTOR-used-Carcinoma, Hepatocellular', 'MTOR-be regulated in-Neoplasms', 'MTOR-up-regulated-Neoplasms', 'MTOR-be regulated in-Carcinoma, Hepatocellular', 'MTOR-up-regulated-Carcinoma, Hepatocellular', 'MTOR-associated-Neoplasms', 'Neoplasms-associated-MTOR', 'Metabolic Diseases-be in-Renal Insufficiency, Chronic', 'INS-be common metabolic disorder in-Renal Insufficiency, Chronic', 'Psoriasis-outweigh-Neoplasms', 'BDNF-implicated-Neurodegenerative Diseases', 'Sleep Initiation and Maintenance Disorders-develop-Hallucinations', 'Sleep Initiation and Maintenance Disorders-treat-Urinary Tract Infections', 'Hallucinations-treat-Urinary Tract Infections', 'Non-alcoholic Fatty Liver Disease-correlated-Hypertension', 'Non-alcoholic Fatty Liver Disease-correlated-Metabolic Syndrome', 'Non-alcoholic Fatty Liver Disease-correlated-Glucose', 'Hypertension-correlated-Glucose', 'Metabolic Syndrome-correlated-Glucose', 'Metabolic Diseases-remain-Neoplasms', 'SIRT1-contribute-Metabolic Diseases', 'AIDS Arteritis, Central Nervous System-be in-HIV Infections', 'SIRT1-remain-Neoplasms', 'KL-accelerate-Calcitriol', 'AIDS Arteritis, Central Nervous System-include-Mastocytosis, Systemic', 'KL-accelerate-Death', 'KL-accelerate-Hyperphosphatemia', 'HIV Infections-include-Inflammation', 'HIV Infections-include-Mastocytosis, Systemic', 'HAND2-identify-Hemorrhage', 'HAND2-identify-Endometrial Neoplasms', 'AIDS Arteritis, Central Nervous System-include-CD4', 'HIV Infections-include-CD4', 'Hypoxia-occur in-Neoplasms', 'Hypoxia-investigate-SIRT1', 'Neoplasms-investigate-SIRT1', 'Waldenstrom Macroglobulinemia-treat-Neuromyelitis Optica', 'Waldenstrom Macroglobulinemia-treat-Etoposide', 'Carcinoma, Non-Small-Cell Lung-exposed-Hypoxia', 'SIRT1-downregulated-Carcinoma, Non-Small-Cell Lung', 'SIRT1-exposed-Hypoxia', 'BIN1-measure-Alzheimer Disease', 'BIN1-correlate-Dementia', 'BIN1-be in-Alzheimer Disease', 'Microsatellite Instability-associated-Colorectal Neoplasms, Hereditary Nonpolyposis', 'Colorectal Neoplasms, Hereditary Nonpolyposis-associated-Microsatellite Instability', 'Colorectal Neoplasms-associated-Colorectal Neoplasms, Hereditary Nonpolyposis', 'Colorectal Neoplasms, Hereditary Nonpolyposis-associated-Colorectal Neoplasms', 'Microsatellite Instability-associated-BRAF', 'BRAF-associated-Microsatellite Instability', 'Colorectal Neoplasms-associated-BRAF', 'BRAF-associated-Colorectal Neoplasms', 'SIRT2-act as-Neoplasms', 'SIRT2-act as-Breast Neoplasms', 'Lipofuscin-implicate-Stargardt Disease', 'Lipofuscin-implicate-Blindness', 'Ovarian Diseases-suggest-AGER', 'BDNF-contribute-Alzheimer Disease', 'Ocular Motility Disorders-improve-Infarction', 'EPHA2-promote-Ocular Motility Disorders', 'EPHA2-improve-Infarction', 'Myocardial Infarction-include-Cerebral Infarction', 'Coronary Artery Disease-include-Cerebral Infarction', 'Leukoencephalopathies-include-Cerebral Infarction', 'Diabetes Mellitus-associated-Arteriolosclerosis', 'Arteriolosclerosis-associated-Diabetes Mellitus', 'JAZF1-associated-Arteriolosclerosis', 'Arteriolosclerosis-associated-JAZF1', 'Triglycerides-include-Cerebral Infarction', 'Leukotrienes-described-Chemical and Drug Induced Liver Injury', 'Leukotrienes-described-Churg-Strauss Syndrome', 'rs864745-associated-Arteriolosclerosis', 'Arteriolosclerosis-associated-rs864745', 'Infliximab-hyperactivate-Nerve Degeneration', 'rs63750847-show-Alzheimer Disease', 'Neoplasms-support-Colorectal Neoplasms', 'SOCS3-expressed-Neoplasms', 'SOCS3-support-Colorectal Neoplasms', 'BDNF-play-Neurodegenerative Diseases', 'Infertility, Female-followed-Ovarian Neoplasms', 'Primary Ovarian Insufficiency-followed-Ovarian Neoplasms', 'Ovarian Neoplasms-followed-AKT1', 'BACE1-occur-Alzheimer Disease', 'BACE1-occur-Nervous System Diseases', 'Anthracyclines-reported-Cardiotoxicity', 'Anthracyclines-reported-Diabetes Mellitus', 'LMNA-linked-Progeria', 'Anthracyclines-reported-Hypertension', 'Infections-develop-Malnutrition', 'Infections-develop-Ascorbic Acid', 'Ascorbic Acid-include-Malnutrition', 'Carcinoma, Non-Small-Cell Lung-benefit-Drug-Related Side Effects and Adverse Reactions', 'EGFR-mutate-Carcinoma, Non-Small-Cell Lung', 'EPO-used-Neoplasms', 'EPO-associated-Neoplasms', 'Neoplasms-associated-EPO', 'ELN-include changes be-Fibrosis', 'MTOR-dysregulated-Neoplasms', 'MTOR-dysregulated-Diabetes Mellitus', 'MTOR-dysregulated-Obesity', 'MTOR-dysregulated-Autoimmune Diseases', 'MTOR-dysregulated-Heredodegenerative Disorders, Nervous System', 'COL18A1-associated-Neoplasms', 'Neoplasms-associated-COL18A1', 'CIDEC-associated-Neoplasms', 'Neoplasms-associated-CIDEC', 'CIDEC-include-Neoplasms', 'CIDEC-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-CIDEC', 'CIDEC-include-Diabetes Mellitus', 'CIDEC-associated-Obesity', 'Obesity-associated-CIDEC', 'MAPT-classify-Alzheimer Disease', 'MAPT-used-Alzheimer Disease', 'MAPT-used-Abnormalities, Drug-Induced', 'MAPT-classify-Abnormalities, Drug-Induced', 'Death-be in-Kidney Failure, Chronic', 'KL-associated-Kidney Failure, Chronic', 'Kidney Failure, Chronic-associated-KL', 'KL-reported-Coronary Artery Disease', 'KL-reported-Cerebral Infarction', 'DCXR-implicated-Neoplasms', 'DCXR-implicated-Diabetes Mellitus', 'DCXR-implicated-Infertility, Male', 'FOXO3-downregulated-Neoplasms', 'FOXO3-known-Neoplasms', 'FOXO3-identified-Adenocarcinoma of Lung', 'PRTN3-associate-Cardiovascular Diseases', 'Cardiovascular Diseases-associate-PRTN3', 'PRTN3-associate-Death', 'Death-associate-PRTN3', 'PRTN3-associate-Arthritis, Rheumatoid', 'Arthritis, Rheumatoid-associate-PRTN3', 'Diabetes Mellitus, Type 2-associate-Communicable Diseases', 'Communicable Diseases-associate-Diabetes Mellitus, Type 2', 'Infliximab-indicate-Muscle Weakness', 'Diabetes Mellitus, Type 2-affect-Hyperglycemia', 'Infliximab-indicate-Heart Failure', 'Communicable Diseases-associate-Diabetic Nephropathies', 'Diabetic Nephropathies-associate-Communicable Diseases', 'Communicable Diseases-affect-Hyperglycemia', 'Diabetic Nephropathies-affect-Hyperglycemia', 'KL-decreased-Diabetes Mellitus, Type 2', 'KL-associate-Communicable Diseases', 'Communicable Diseases-associate-KL', 'KL-decreased-Communicable Diseases', 'KL-associate-Diabetic Nephropathies', 'Diabetic Nephropathies-associate-KL', 'KL-affect-Diabetic Nephropathies', 'Hyperglycemia-affect-KL', 'Renal Insufficiency, Chronic-reclassified-Cardiovascular Diseases', 'Renal Insufficiency, Chronic-reclassified-Death', 'Renal Insufficiency, Chronic-reclassified-rs13038305', 'rs13038305-reclassified-Cardiovascular Diseases', 'rs13038305-reclassified-Death', 'Nervous System Diseases-prevent-Diabetes Mellitus', 'Nervous System Diseases-drive-Mandibular Nerve Injuries', 'Diabetes Mellitus-drive-Mandibular Nerve Injuries', 'Glucose-prevent-Diabetes Mellitus', 'Glucose-drive-Mandibular Nerve Injuries', 'Glucose-undergo-Pulmonary Disease, Chronic Obstructive', 'Prostaglandins I-include-Pulmonary Arterial Hypertension', 'Prostaglandins I-include-Hypertension, Pulmonary', 'Alzheimer Disease-associate-Tauopathies', 'Tauopathies-associate-Alzheimer Disease', 'Tauopathies-associate with-Dementia', 'Triglycerides-associated-Dementia', 'Dementia-associated-Triglycerides', 'Heart Failure-associated-Triglycerides', 'Triglycerides-associated-Heart Failure', 'Parkinson Disease-associated-Triglycerides', 'Triglycerides-associated-Parkinson Disease', 'RECQL4-play-Breast Neoplasms', 'INS-of mechanism be-Diabetes Mellitus', 'Lung Neoplasms-compared-HIV Infections', 'Lung Neoplasms-base-HIV Infections', 'Lung Neoplasms-compared-CD4', 'Lung Neoplasms-base-CD4', 'SIRT1-shown-Eye Diseases', 'SIRT1-shown-Cataract', 'SIRT1-shown-Retinal Degeneration', 'SIRT1-shown-Optic Neuritis', 'SIRT1-shown-Uveitis', 'Cataract-include-Eye Diseases', 'Nerve Degeneration-include-Eye Diseases', 'Glaucoma-include-Eye Diseases', 'Nerve Degeneration-be in-Glaucoma', 'SIRT1-protection against-Eye Diseases', 'SIRT1-provide-Eye Diseases', 'H19-classified-Obesity', 'SIRT1-protection against-Cataract', 'SIRT1-provide-Cataract', 'SIRT1-provide-Nerve Degeneration', 'SIRT1-provide-Glaucoma', 'Fish Oils-reduce-Atrial Fibrillation', 'Fish Oils-reduce-Sinoatrial Block', 'APOE-decrease-Dementia', 'APOE-decrease-Alzheimer Disease', 'Weight Gain-lead-Cardiovascular Diseases', 'Weight Gain-lead-Diabetes Mellitus, Type 2', 'Weight Gain-lead-Atherosclerosis', 'Weight Gain-lead-INS', 'Diabetes Mellitus-include-Hyperinsulinism', 'MAPT-differ-Dementia, Vascular', 'MAPT-differ-Stroke', 'LMNB1-cause-Leukodystrophy, Metachromatic', 'LMNA-give-Muscular Dystrophies', 'LMNA-encode-Aging, Premature', 'LMNB1-cause-Genetic Diseases, Inborn', 'LMNA-encode-Progeria', 'LMNB1-lead-Genetic Diseases, Inborn', 'LMNB1-discuss-Leukodystrophy, Metachromatic', 'IL6-associated-Stroke', 'Stroke-associated-IL6', 'IL6-associated-Infections', 'Infections-associated-IL6', 'Neoplasms-show-Mitochondrial Diseases', 'Neoplasms-be with-SIRT3', 'Mitochondrial Diseases-undergo apoptosis in-SIRT3', 'Mitochondrial Diseases-show-SIRT3', 'Inflammation-associated-Fractures, Bone', 'Fractures, Bone-associated-Inflammation', 'Inflammation-measured-Fractures, Bone', 'CRP-associated-Fractures, Bone', 'Fractures, Bone-associated-CRP', 'AKT1-linked-Diabetes Mellitus', 'Communicable Diseases-encompass-Metabolic Syndrome', 'Communicable Diseases-encompass-Diabetes Mellitus', 'Communicable Diseases-encompass-Dyslipidemias', 'Obesity-related-Triglycerides', 'Communicable Diseases-encompass-Obesity, Abdominal', 'Communicable Diseases-encompass-Hypertension', 'Communicable Diseases-encompass-Inflammation', 'Retinitis-involved-Alzheimer Disease', 'BACE1-cleave-Alzheimer Disease', 'Lipodystrophy-reveal-Werner Syndrome', 'INS-reveal-Werner Syndrome', 'INS-underline-Diabetes Mellitus', 'INS-underline-Obesity', 'INS-underline-Dyslipidemias', 'INS-underline-Hypertension', 'IAPP-accumulate-Cerebrovascular Disorders', 'IAPP-accumulate-Diabetes Mellitus', 'Alzheimer Disease-detected-Diabetes Mellitus', 'IAPP-detected-Alzheimer Disease', 'IAPP-detected-Diabetes Mellitus', 'SOD2-associated-Neurodegenerative Diseases', 'Neurodegenerative Diseases-associated-SOD2', 'SOD2-associated-Parkinson Disease', 'Parkinson Disease-associated-SOD2', 'Diabetes Mellitus-type-rs4746', 'GDF15-associated-Dementia', 'Dementia-associated-GDF15', 'Diabetes Mellitus-use-IFNG', 'OTX2-involve-Inflammation', 'DYNC1H1-cause-Motor Neuron Disease', 'DYNC1H1-cause-Pain Insensitivity, Congenital', 'Mitochondrial Diseases-develop-Hyperinsulinism', 'Mitochondrial Diseases-develop-Hyperglycemia', 'Mitochondrial Diseases-progress-Glucose', 'Hyperinsulinism-progress-Glucose', 'Hyperglycemia-progress-Glucose', 'APOE-effect of be-Dementia', 'CD4-associated-Sarcoma, Kaposi', 'Sarcoma, Kaposi-associated-CD4', 'CD4-associated-Lymphoma', 'Lymphoma-associated-CD4', 'Renal Insufficiency, Chronic-increase-Vascular Calcification', 'CD4-associated-Neoplasms', 'Neoplasms-associated-CD4', 'FGF23-increase-Vascular Calcification', 'Hypertension-translate-Death', 'Hypertension-be in-ADIPOQ', 'ADIPOQ-translate-Death', 'SOD2-be in-Neurodegenerative Diseases', 'SOD2-be in-Stroke', 'Obesity-related-Fatty Liver', 'SLC17A5-related-Fatty Liver', 'Triglycerides-related-Fatty Liver', 'Heart Failure-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-Heart Failure', 'Ascorbic Acid-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-Ascorbic Acid', 'SIRT2-associated-Alzheimer Disease', 'Alzheimer Disease-associated-SIRT2', 'SIRT2-confirm-Alzheimer Disease', 'Metabolic Syndrome-found-Triglycerides', 'Hypertension-found-Triglycerides', 'Multiple Organ Failure-cause-Aneurysm', 'Multiple Organ Failure-cause-Kidney Diseases', 'Inflammation-cause-Atherosclerosis', 'Inflammation-cause-Aneurysm', 'Inflammation-cause-Kidney Diseases', 'Breast Neoplasms-approve-TNFSF11', 'AGER-implicated-Atherosclerosis', 'Prostatic Neoplasms-approve-TNFSF11', 'AGER-implicated-Neurodegenerative Diseases', 'AGER-implicated-Arthritis', 'AGER-implicated-Diabetes Mellitus', 'Breast Neoplasms-approve-Denosumab', 'Prostatic Neoplasms-approve-Denosumab', 'AGER-implicated-Neoplasms', 'Carcinogenesis-inhibit-Neoplasms', 'CLU-inhibit-Carcinogenesis', 'CLU-inhibit-Neoplasms', 'Hemorrhage-encode-COX8A', 'Diabetes Mellitus-characterized-Insulin Resistance', 'Metabolic Diseases-characterized-Insulin Resistance', 'Glucose-characterized-INS', 'APOE-explained-Alzheimer Disease', 'Glucose-characterized-Insulin Resistance', 'Diabetes Mellitus-carry-Hypoglycemia', 'Diabetes Mellitus-carry-Glucose', 'NR3C2-contribute-Inflammation', 'NR3C2-contribute-Fibrosis', 'Renal Insufficiency, Chronic-achieve-Diabetes Mellitus', 'Renal Insufficiency, Chronic-achieve-Glucose', 'Glucose-cause-Metabolic Syndrome', 'Prostaglandins-produce-Inflammation', 'Prostaglandins-produce-Pain', 'Obesity-be predominant with-Polycystic Ovary Syndrome', 'INS-be predominant with-Polycystic Ovary Syndrome', 'Alzheimer Disease-play-INS', 'INS-used-Diabetes Mellitus', 'Muscular Dystrophies-be with-Intestinal Pseudo-Obstruction', 'Uremia-prevent-Kidney Diseases', 'Uremia-prevent-Ascorbic Acid', 'Kidney Diseases-prevent-Ascorbic Acid', 'Cardiomyopathies-associated-Heart Diseases', 'Heart Diseases-associated-Cardiomyopathies', 'Cardiomyopathies-associated-Genetic Diseases, Inborn', 'Genetic Diseases, Inborn-associated-Cardiomyopathies', 'Heart Diseases-associated-Genetic Diseases, Inborn', 'Genetic Diseases, Inborn-associated-Heart Diseases', 'LMNA-involved-Cardiomyopathies', 'LMNA-involved-Heart Diseases', 'LMNA-involved-Genetic Diseases, Inborn', 'Venous Thromboembolism-prevent-Hemorrhage', 'Enoxaparin-prevent-Hemorrhage', 'Cardiovascular Diseases-include-Diabetes Mellitus', 'Diabetes Mellitus, Type 2-be with-Parkinson Disease', 'ERCC6-cause-Contracture', 'ERCC6-cause-Cataract', 'ERCC6-cause-Death', 'Enoxaparin-be with-Hemorrhage', 'Ghrelin-affect-Cachexia', 'Ghrelin-affect-Inflammation', 'Pulmonary Fibrosis-develop-Bleomycin', 'Fibrosis-develop-Bleomycin', 'Asthma-associated-Bacterial Infections', 'Bacterial Infections-associated-Asthma', 'CRP-associated-Bacterial Infections', 'Bacterial Infections-associated-CRP', 'GH1-protected-Neoplasms', 'GH1-protected-Diabetes Mellitus', 'GGH-provide-Diabetes Mellitus', 'GGH-provide-Neoplasms', 'CX3CR1-underlie beta cell dysfunction in-Diabetes Mellitus', 'Immunologic Deficiency Syndromes-progression of-Pancreatic Neoplasms', 'Immunologic Deficiency Syndromes-accelerate-Pancreatic Neoplasms', 'TP53INP1-progression of-Pancreatic Neoplasms', 'TP53INP1-accelerate-Pancreatic Neoplasms', 'Death-interact with-Alzheimer Disease', 'APOE-increase-Death', 'APOE-interact-Alzheimer Disease', 'Anemia-contribute-ADIPOQ', 'Kidney Diseases-represent-ADIPOQ', 'APOD-induced-Neurodegenerative Diseases', 'APOD-play-Alzheimer Disease', 'PIM1-discovered-Leukemia', 'PIM1-discovered-Lymphoma', 'Neoplasms-be with-von Hippel-Lindau Disease', 'FLCN-cause-Birt-Hogg-Dube Syndrome', 'FLCN-cause-Neoplasms', 'FLCN-cause-von Hippel-Lindau Disease', 'PIM1-increased-Neoplasms', 'PIM1-found-Neoplasms', 'PIM1-increased-Prostatic Neoplasms', 'MYO5A-associated-Neurologic Manifestations', 'Neurologic Manifestations-associated-MYO5A', 'Drug Hypersensitivity-include-TNF', 'Drug-Related Side Effects and Adverse Reactions-include-TNF', 'Acquired Immunodeficiency Syndrome-defined-HIV Infections', 'CD4-defined-HIV Infections', 'Carcinoma, Hepatocellular-associated-Liver Cirrhosis', 'Liver Cirrhosis-associated-Carcinoma, Hepatocellular', 'KL-be in-Carcinoma, Hepatocellular', 'KL-associated-Liver Cirrhosis', 'Liver Cirrhosis-associated-KL', 'SOD1-underlie-Amyotrophic Lateral Sclerosis', 'SPON1-associated-Alzheimer Disease', 'Alzheimer Disease-associated-SPON1', 'AKT1-emerging-Neoplasms', 'Drug-Related Side Effects and Adverse Reactions-cause-Neurodegenerative Diseases', 'AKT1-emerging-Diabetes Mellitus, Type 2', 'Drug-Related Side Effects and Adverse Reactions-test-Valproic Acid', 'AKT1-emerging-Heart Diseases', 'AKT1-emerging-Neurodegenerative Diseases', 'Neurodegenerative Diseases-test-Valproic Acid', 'Headache Disorders, Secondary-be prominent because-Polyuria', 'Headache Disorders, Secondary-result-Polyuria', 'Headache Disorders, Secondary-result-Polydipsia', 'Headache Disorders, Secondary-be prominent because-Glucose', 'Glucose-result-Polyuria', 'Glucose-result-Polydipsia', 'MTOR-increase-Diabetes Mellitus', 'Cholesterol-used-Cardiovascular Diseases', 'Cholesterol-increase-Diabetes Mellitus', 'Aging, Premature-cause-Leukodystrophy, Metachromatic', 'Aging, Premature-cause-LMNB1', 'TNFAIP3-identified-Lymphoma', 'TNFAIP3-identified-Lymphoma, Extranodal NK-T-Cell', 'TNFAIP3-identified-Lymphoproliferative Disorders', 'Epilepsy-lead-Death', 'Vision Disorders-lead-Death', 'TPP1-characterized-Epilepsy', 'TPP1-characterized-Vision Disorders', 'TPP1-characterized-Ataxia', 'TPP1-lead-Death', 'Ovarian Neoplasms-include-Neoplasms', 'AKT1-activated-Neoplasms', 'Carcinogenesis-present-Neoplasms', 'AKT1-drive-Carcinogenesis', 'AKT1-activated-Ovarian Neoplasms', 'AKT1-present-Neoplasms', 'CRP-explain-Obesity', 'Hypertension-type-Diabetes Mellitus', 'BDNF-affect-Neurodegenerative Diseases', 'TRH-associated-Fatigue', 'Fatigue-associated-TRH', 'TRH-associated-Sleep Wake Disorders', 'Sleep Wake Disorders-associated-TRH', 'Fatigue-be in-Neoplasms', 'TRH-investigate-Fatigue', 'TRH-investigate-Neoplasms', 'Hyperglycemia-contribute-Osteoarthritis', 'Glucose-contribute-Osteoarthritis', 'Liver Diseases-include-Diabetes Mellitus', 'Liver Diseases-include-SLC5A2', 'Diabetes Mellitus, Type 2-caused-Hyperglycemia', 'Liver Diseases-include-Canagliflozin', 'Fatty Acids-linked-Diabetes Mellitus', 'Fatty Acids-linked-Coronary Artery Disease', 'Primary Ovarian Insufficiency-associated-ADIPOQ', 'ADIPOQ-associated-Primary Ovarian Insufficiency', 'Primary Ovarian Insufficiency-involved-ADIPOQ', 'Ovarian Diseases-associated-ADIPOQ', 'ADIPOQ-associated-Ovarian Diseases', 'Ovarian Diseases-involved-ADIPOQ', 'Fluorodeoxyglucose F18-reveal-Alzheimer Disease', 'Fluorodeoxyglucose F18-reveal-Aphasia', 'Pain-affect-Pelvic Girdle Pain', 'Pain-present-F8', 'Pelvic Girdle Pain-present-F8', 'Fluorodeoxyglucose F18-reveal-Atrophy', 'Alzheimer Disease-show-Atrophy', 'Alzheimer Disease-show-Aphasia', 'Fluorodeoxyglucose F18-be with-Atrophy', 'Neoplasms-overexpressed-Carcinoma, Hepatocellular', 'SIRT1-impair-Neoplasms', 'ANGPTL2-accelerate-Inflammation', 'Neoplasms-overexpressed-SIRT1', 'SIRT1-overexpressed-Carcinoma, Hepatocellular', 'ADIPOQ-tested-Myocardial Infarction', 'ADIPOQ-tested-Diabetes Mellitus', 'Angiomyolipoma-include-Neoplasms', 'Desmoplastic Small Round Cell Tumor-include-Neoplasms', 'Gastrointestinal Stromal Tumors-include-Neoplasms', 'Glomus Tumor-include-Neoplasms', 'Leiomyoma-include-Neoplasms', 'Leiomyosarcoma-include-Neoplasms', 'Lipoma-include-Neoplasms', 'Liposarcoma-include-Neoplasms', 'Neurofibrosarcoma-include-Neoplasms', 'Fasciitis-include-Neoplasms', 'Rhabdomyosarcoma-include-Neoplasms', 'Neurilemmoma-include-Neoplasms', 'IGF1R-regulate-Heart Diseases', 'Solitary Fibrous Tumors-include-Neoplasms', 'Sarcoma, Synovial-include-Neoplasms', 'IGF1R-regulate-Neoplasms', 'Carcinoma-include-Neoplasms', 'Wilms Tumor-include-Neoplasms', 'SIRT1-observed-Neoplasms', 'SIRT1-observed-Angiomyolipoma', 'SIRT1-observed-Glomus Tumor', 'SIRT1-observed-Leiomyoma', 'Myotonia Congenita-range-Malignant Hyperthermia', 'Myotonia Congenita-associated-Muscle Weakness', 'Muscle Weakness-associated-Myotonia Congenita', 'SIRT1-observed-Leiomyosarcoma', 'SIRT1-observed-Rhabdomyosarcoma', 'Malignant Hyperthermia-associated-Muscle Weakness', 'Muscle Weakness-associated-Malignant Hyperthermia', 'RYR1-range-Myotonia Congenita', 'RYR1-associated-Muscle Weakness', 'Muscle Weakness-associated-RYR1', 'NF2-characterized-Neoplasms', 'Sugars-reveal-Non-alcoholic Fatty Liver Disease', 'Sugars-reveal difference without-Carcinoma, Hepatocellular', 'Neoplasms-express-Sugars', 'KLF2-involved-Cerebrovascular Disorders', 'KLF2-involved-Alzheimer Disease', 'SIRT1-connected-Diabetes Mellitus, Type 2', 'SIRT1-connected-Osteoporosis', 'SIRT1-reviewed-Neoplasms', 'SIRT1-reviewed-Sarcoma', 'SIRT1-reviewed-Angiomyolipoma', 'SIRT1-reviewed-Desmoplastic Small Round Cell Tumor', 'Osteoarthritis-treat-Cartilage Diseases', 'SIRT1-reviewed-Gastrointestinal Stromal Tumors', 'SIRT1-serve-Osteoarthritis', 'SIRT1-treat-Osteoarthritis', 'SIRT1-reviewed-Glomus Tumor', 'SIRT1-reviewed-Leiomyoma', 'SIRT1-reverse-Cartilage Diseases', 'SIRT1-reviewed-Leiomyosarcoma', 'SIRT1-reviewed-Lipoma', 'SIRT1-reviewed-Liposarcoma', 'SIRT1-reviewed-Neurofibrosarcoma', 'SIRT1-reviewed-Fasciitis', 'SIRT1-reviewed-Osteosarcoma', 'SIRT1-reviewed-Rhabdomyosarcoma', 'SIRT1-reviewed-Neurilemmoma', 'SIRT3-be in-Carcinoma, Hepatocellular', 'Metabolic Syndrome-defined-Hyperglycemia', 'SIRT1-reviewed-Solitary Fibrous Tumors', 'SIRT1-reviewed-Sarcoma, Synovial', 'SIRT3-be lower in-Neoplasms, Nerve Tissue', 'SIRT1-reviewed-Carcinoma', 'Metabolic Syndrome-defined-Hypertriglyceridemia', 'BRIP1-associated-Breast Neoplasms', 'Breast Neoplasms-associated-BRIP1', 'BRIP1-associated-Fanconi Anemia', 'Fanconi Anemia-associated-BRIP1', 'SIRT1-reviewed-Wilms Tumor', 'Metabolic Syndrome-component of-INS', 'INS-defined-Obesity', 'INS-defined-Hyperglycemia', 'INS-defined-Hypertension', 'INS-defined-Hypertriglyceridemia', 'Fever-associated-HIV Infections', 'HIV Infections-associated-Fever', 'Fever-associated-Lymphoma', 'Lymphoma-associated-Fever', 'Fever-undergo-Lymphoma', 'Neutropenia-associated-HIV Infections', 'HIV Infections-associated-Neutropenia', 'Neutropenia-associated-Lymphoma', 'Lymphoma-associated-Neutropenia', 'Neutropenia-undergo-Lymphoma', 'HIV Infections-undergo-Lymphoma', 'HIV Infections-include-Lymphoma', 'Fever-associated-CD4', 'CD4-associated-Fever', 'Neutropenia-associated-CD4', 'CD4-associated-Neutropenia', 'CD4-undergo-Lymphoma', 'WWOX-inactivated-Neoplasms', 'WWOX-inactivated-Breast Neoplasms', 'Cardiovascular Diseases-be in-Albuminuria', 'CST3-identify-Renal Insufficiency, Chronic', 'CST3-identify-Death', 'CST3-identify-Cardiovascular Diseases', 'BTLA-associated-Autoimmune Diseases', 'Autoimmune Diseases-associated-BTLA', 'BTLA-associated-Arbovirus Infections', 'Arbovirus Infections-associated-BTLA', 'BTLA-associated-Neoplasms', 'Neoplasms-associated-BTLA', 'RECQL4-implicated-Growth Disorders', 'RECQL4-implicated-Neoplasms', 'APOE-associated-Glucose Metabolism Disorders', 'Glucose Metabolism Disorders-associated-APOE', 'Metabolic Syndrome-demonstrate-Cardiovascular Diseases', 'IGF1-demonstrate-Cardiovascular Diseases', 'Alzheimer Disease-recruited-Epilepsy, Temporal Lobe', 'Alzheimer Disease-undergo-Epilepsy, Temporal Lobe', 'Dementia, Vascular-recruited-Epilepsy, Temporal Lobe', 'Dementia, Vascular-undergo-Epilepsy, Temporal Lobe', 'Diabetes Mellitus-affect-Ischemia', 'Kidney Diseases-indicated-Brain Diseases', 'Kidney Diseases-indicated-Neurodegenerative Diseases', 'Kidney Diseases-associate-Brain Diseases', 'Brain Diseases-associate-Kidney Diseases', 'Kidney Diseases-associate-Neurodegenerative Diseases', 'Neurodegenerative Diseases-associate-Kidney Diseases', 'Brain Diseases-indicated-Neurodegenerative Diseases', 'ACVRL1-explain-Osteogenesis Imperfecta', 'ACVRL1-explain-Thyroid Cancer, Papillary', 'Alzheimer Disease-accompanied-Memory Disorders', 'Memory Disorders-accompanied-MAPT', 'INS-known-Metabolic Syndrome', 'INS-insufficiency of be-Osteoporosis', 'INS-insufficiency of be-Diabetes Mellitus', 'Myalgia-shown-FLNC', 'NF1-compare-Fractures, Bone', 'Bone Diseases, Metabolic-prevent-Osteoporosis', 'NF1-be with-Bone Diseases, Metabolic', 'NF1-prevent-Osteoporosis', 'FLNC-caused-Muscular Diseases', 'Dementia-adjusted-Cardiovascular Diseases', 'Diabetes Mellitus-affect-Peripheral Arterial Disease', 'Diabetes Mellitus-for globulin be-SHBG', 'Dementia-adjusted-Diabetes Mellitus', 'FLNC-result-Muscular Diseases', 'SHBG-affect-Peripheral Arterial Disease', 'FLNC-result-Sotos Syndrome', 'Dementia-adjusted-Cholesterol', 'CIC-increased-Neoplasms', 'Diabetes Mellitus-associated-Cerebral Infarction', 'Cerebral Infarction-associated-Diabetes Mellitus', 'Cholesterol-associated-Cerebral Infarction', 'Cerebral Infarction-associated-Cholesterol', 'Sarcopenia-defined-Ataxia', 'Sarcopenia-defined-H19', 'Carcinoma, Hepatocellular-induce-Heart Arrest', 'CCND1-induce-Heart Arrest', 'rs34637584-associated-Parkinson Disease', 'Parkinson Disease-associated-rs34637584', 'rs34637584-associated-Urinary Bladder, Neurogenic', 'Urinary Bladder, Neurogenic-associated-rs34637584', 'Cholesterol-associated-Memory Disorders', 'Memory Disorders-associated-Cholesterol', 'BMI1-be in-Medulloblastoma', 'Acquired Immunodeficiency Syndrome-involve-Opportunistic Infections', 'VASH1-make-Death', 'ADIPOQ-play-Neurodegenerative Diseases', 'HCN1-play-Epilepsy', 'HCN1-play-Alzheimer Disease', 'Hypoglycemia-be in-Heart Failure', 'Neurodegenerative Diseases-identified-Fluorodeoxyglucose F18', 'Diabetes Mellitus, Type 2-characterized-Insulinoma', 'Hypertension-raise-Diabetes Mellitus', 'Hypertension-raise-Cholesterol', 'Inflammation-associated-Hemolytic-Uremic Syndrome', 'Hemolytic-Uremic Syndrome-associated-Inflammation', 'Inflammation-associated-DNMT1', 'DNMT1-associated-Inflammation', 'FOXA1-be in-Breast Neoplasms', 'FOXA1-overexpressed-Lung Neoplasms', 'FOXM1-upregulated-Lymphoma, B-Cell', 'FOXA1-be mutated in-Neoplasms', 'FOXA1-overexpressed-Neoplasms', 'FOXA1-overexpressed-Thyroid Carcinoma, Anaplastic', 'FOXA1-be mutated in-Prostatic Neoplasms', 'FOXA1-overexpressed-Prostatic Neoplasms', 'FOXP1-associated-Carcinoma, Hepatocellular', 'Carcinoma, Hepatocellular-associated-FOXP1', 'FOXP1-associated-Breast Neoplasms', 'Breast Neoplasms-associated-FOXP1', 'INS-modify-Weight Loss', 'INS-seen-Weight Loss', 'INS-modify-Obesity', 'AGER-linked-Inflammation', 'AGER-linked-Diabetes Mellitus', 'Alzheimer Disease-diagnosed-Diabetes Mellitus', 'Glucose-used-Heart Failure', 'Hypertension-be with-Diabetes Mellitus', 'Diabetes Mellitus-possess-APOE', 'Acute Kidney Injury-become-Neoplasms', 'Acute Kidney Injury-poise-Neoplasms', 'CDKN2A-become-Neoplasms', 'CDKN2A-poise-Neoplasms', 'PTHLH-consisted-Glucose Metabolism Disorders', 'PTHLH-coupled-Glucose Metabolism Disorders', 'PTHLH-consisted-Chemical and Drug Induced Liver Injury', 'PTHLH-coupled-Chemical and Drug Induced Liver Injury', 'Diabetes Mellitus-increase-Peripheral Arterial Disease', 'Diabetes Mellitus-elevate-Glucose', 'Glucose-increase-Peripheral Arterial Disease', 'SORL1-chosen-Alzheimer Disease', 'KL-become-Multiple Sclerosis', 'Inflammation-lead-Communicable Diseases', 'Fluorodeoxyglucose F18-show-Alzheimer Disease', 'INS-lead-Communicable Diseases', 'SNCA-associated-Parkinson Disease', 'Parkinson Disease-associated-SNCA', 'Cerebrovascular Disorders-connect-Hypertension', 'Cerebrovascular Disorders-connect-Alzheimer Disease', 'Cerebrovascular Disorders-connect-Hypoxia', 'Hypertension-connect-Hypoxia', 'Alzheimer Disease-connect-Hypoxia', 'Cerebrovascular Disorders-connect-APOE', 'Diabetes Mellitus-carry-APOE', 'Burkitt Lymphoma-cooperate-Neoplasms', 'Burkitt Lymphoma-cooperate-MYC', 'MYC-cooperate-Neoplasms', 'FOXP3-associate-Neoplasms', 'Neoplasms-associate-FOXP3', 'FOXP3-associate-Carcinoma, Non-Small-Cell Lung', 'Carcinoma, Non-Small-Cell Lung-associate-FOXP3', 'Osteoarthritis-associated-Glucosamine', 'Glucosamine-associated-Osteoarthritis', 'Neoplasms-associated-Glucosamine', 'Glucosamine-associated-Neoplasms', 'Myocardial Infarction-associated-Glucosamine', 'Glucosamine-associated-Myocardial Infarction', 'Heart Diseases-associated-Glucosamine', 'Glucosamine-associated-Heart Diseases', 'Dementia-modified-Obesity', 'LEP-modified-Obesity', 'Neurodegenerative Diseases-differentiated-Alzheimer Disease', 'Neurodegenerative Diseases-differentiated-Parkinson Disease', 'Neurodegenerative Diseases-compared-SNCA', 'Neurodegenerative Diseases-play-SNCA', 'SNAP25-associated-Dementia', 'Dementia-associated-SNAP25', 'rs758439420-exhibit-Pigmentation Disorders', 'rs758439420-exhibit-Reflex, Abnormal', 'Obesity-compensate-Sleep Initiation and Maintenance Disorders', 'INS-be common during-Obesity', 'INS-compensate-Sleep Initiation and Maintenance Disorders', 'rs63750847-protect-Alzheimer Disease', 'Alzheimer Disease-show-CLU', 'CISD2-identified-Wolfram Syndrome', 'CISD2-identified-Optic Atrophy', 'CISD2-identified-Diabetes Mellitus', 'CISD2-identified-Deafness', 'CISD2-identified-Diabetes Insipidus', 'VDR-delay-Chronic Disease', 'VDR-delay-Osteoporosis', 'VDR-delay-Diabetes Mellitus', 'Ghrelin-associated-Glucose Intolerance', 'Glucose Intolerance-associated-Ghrelin', 'VDR-delay-Cardiovascular Diseases', 'Ghrelin-associated-Metabolic Syndrome', 'Metabolic Syndrome-associated-Ghrelin', 'Parkinsonian Disorders-induced-Parkinson Disease', 'Leukemia, Lymphocytic, Chronic, B-Cell-reduce-Neoplasms', 'Dactinomycin-reduce-Neoplasms', 'Obesity-help-Nerve Degeneration', 'SIRT1-help-Obesity', 'SIRT1-help-Nerve Degeneration', 'Infections-associated-Anodontia', 'Anodontia-associated-Infections', 'Renal Insufficiency, Chronic-examine-Acute Kidney Injury', 'Renal Insufficiency, Chronic-examine-Kidney Diseases', 'Renal Insufficiency, Chronic-examine-Diabetes Mellitus', 'Renal Insufficiency, Chronic-examine-Death', 'Renal Insufficiency, Chronic-examine-Glucose', 'Hodgkin Disease-fall-Cardiac Output, Low', 'CD4-fall-Cardiac Output, Low', 'Cardiovascular Diseases-include-Dementia', 'Cardiovascular Diseases-include-Fatty Acids, Omega-3', 'Diabetes Mellitus-reduce-Nervous System Diseases', 'Diabetes Mellitus-reduce-Glucose', 'Glucose-reduce-Nervous System Diseases', 'Metabolic Syndrome-diagnosed-Diabetes Mellitus', 'Necrosis-associated-Death', 'Death-associated-Necrosis', 'Sarcopenia-include-Muscle Weakness', 'Sarcopenia-play-Weight Gain', 'Sarcopenia-play-Glucose', 'Muscle Weakness-play-Glucose', 'Obesity-include-Dementia', 'Diabetes Mellitus-include-Dementia', 'INS-include-Dementia', 'Myasthenia Gravis-develop-Cytomegalovirus Infections', 'Myasthenia Gravis-develop-Epstein-Barr Virus Infections', 'Myasthenia Gravis-develop-Mycophenolic Acid', 'Cytomegalovirus Infections-develop-Mycophenolic Acid', 'Epstein-Barr Virus Infections-develop-Mycophenolic Acid', 'Diabetes Mellitus, Type 2-determined-Diabetes Mellitus', 'Diabetes Mellitus, Type 2-determined-Glucose', 'Diabetes Mellitus, Type 2-use-Glucose', 'Diabetes Mellitus-determined-Glucose', 'Glucose Metabolism Disorders-serve-Diabetes Mellitus, Type 2', 'Fatty Acids, Omega-3-involve-Alzheimer Disease', 'Docosahexaenoic Acids-give-Alzheimer Disease', 'NFE2L2-restore-Cardiovascular Diseases', 'NFE2L2-restore-Diabetes Mellitus', 'NFE2L2-restore-Atherosclerosis', 'NFE2L2-restore-Stroke', 'APOE-allele of be-Alzheimer Disease', 'SIRT1-be beneficial for-Metabolic Syndrome', 'SCN1A-considered-Nervous System Diseases', 'MYC-prevent-Cardiovascular Diseases', 'MYC-prevent-Neoplasms', 'MYC-prevent-Diabetes Mellitus', 'LMNA-include-Muscular Dystrophy, Emery-Dreifuss', 'LMNA-result-Aging, Premature', 'LMNA-include-Aging, Premature', 'Dementia-use-Stroke', 'Dementia-use-Deglutition Disorders', 'Dementia-use-Glucose', 'Glucose-include-Heart Failure', 'Glucose-associated-Heart Failure', 'Heart Failure-associated-Glucose', 'Weight Loss-include-Glucose', 'Glucose-include-Muscular Diseases', 'Glucose-associated-Muscular Diseases', 'Muscular Diseases-associated-Glucose', 'Liver Diseases-include-Glucose', 'ALDH2-promote-Osteoporosis', 'rs671-promote-Osteoporosis', 'Fatty Acids, Unsaturated-summarize-Inflammation', 'Fatty Acids, Unsaturated-summarize-Neoplasms', 'ATM-seen-Neoplasms', 'FOXO3-trigger expression in-Neuroblastoma', 'FOXO3-trigger-Neoplasms', 'SIRT1-involved-Diabetes Mellitus', 'Movement Disorders-suggest-Obesity', 'Hypothalamic Neoplasms-treat-Metabolic Syndrome', 'SIRT1-involved-Neurodegenerative Diseases', 'Movement Disorders-suggest-INS', 'Hypothalamic Neoplasms-suppress-SIRT1', 'SIRT1-treat-Metabolic Syndrome', 'Fatty Liver-increase-INS', 'Neoplasms-suppress-Breast Neoplasms', 'Cardiovascular Diseases-related-ACE', 'Death-related-ACE', 'Thrombosis-occur-Thrombocythemia, Essential', 'Thrombosis-occur-JAK2', 'Coronary Artery Disease-decrease-ALB', 'Heart Failure-decrease-ALB', 'Atrial Fibrillation-decrease-ALB', 'Heart Failure-based-NFE2L2', 'Mastocytosis-augment-Drug Hypersensitivity', 'SP4-contribute-Mastocytosis', 'SP4-augment-Drug Hypersensitivity', 'Werner Syndrome-include-Inflammation', 'Obesity, Abdominal-regulate-Glucose Metabolism Disorders', 'Obesity, Abdominal-regulate-INS', 'Inflammation-of markers be-Endometriosis', 'Diabetes Mellitus, Type 2-resemble-Insulin Resistance', 'Diabetes Mellitus, Type 2-resemble-INS', 'APOD-upregulated-Brain Injuries, Traumatic', 'APOD-upregulated-Nervous System Diseases', 'APOD-upregulated-Alzheimer Disease', 'Neoplasms-sensitize-Colorectal Neoplasms', 'Colorectal Neoplasms-sensitize-TNFSF10', 'Drug-Related Side Effects and Adverse Reactions-be with-Alzheimer Disease', 'Drug-Related Side Effects and Adverse Reactions-promote-Alzheimer Disease', 'Drug-Related Side Effects and Adverse Reactions-promote-G(M1) Ganglioside', 'Hearing Loss, Central-bear-rs1800796', 'rs1800796-bear-Hypertension', 'rs1800796-bear-Diabetes Mellitus', 'rs1800796-bear-Dyslipidemias', 'Neurodegenerative Diseases-associate-Alzheimer Disease', 'Alzheimer Disease-associate-Neurodegenerative Diseases', 'GSTM1-role in-Neurodegenerative Diseases', 'GSTM1-associate-Alzheimer Disease', 'Alzheimer Disease-associate-GSTM1', 'Infections-curtail-Neoplasms', 'INS-curtail-Neoplasms', 'Urolithiasis-associated-Renal Insufficiency, Chronic', 'Renal Insufficiency, Chronic-associated-Urolithiasis', 'Atazanavir Sulfate-cause-Urolithiasis', 'Atazanavir Sulfate-associated-Renal Insufficiency, Chronic', 'Renal Insufficiency, Chronic-associated-Atazanavir Sulfate', 'Parkinson Disease-assessed-Nerve Degeneration', 'Canavan Disease-mitigate-Neurodegenerative Diseases', 'Canavan Disease-induced-Genetic Diseases, Inborn', 'Neurodegenerative Diseases-induced-Genetic Diseases, Inborn', 'Insulin Resistance-derive-Metabolic Syndrome', 'INS-derive-Metabolic Syndrome', 'KL-quantitate-Diabetes Mellitus', 'KL-quantitate-Renal Insufficiency, Chronic', 'KL-decreased-Diabetes Mellitus', 'KL-increase-Renal Insufficiency, Chronic', 'Hypoglycemia-associated-Fibrosis', 'Fibrosis-associated-Hypoglycemia', 'Hypoglycemia-associated-Cerebrovascular Disorders', 'Cerebrovascular Disorders-associated-Hypoglycemia', 'SIRT1-regulated-Leukemia-Lymphoma, Adult T-Cell', 'SIRT1-regulated-Leukemia', 'RECQL4-associated-Rothmund-Thomson Syndrome', 'Rothmund-Thomson Syndrome-associated-RECQL4', 'Hypertension-include-Renal Insufficiency, Chronic', 'Diabetes Mellitus-include-Renal Insufficiency, Chronic', 'Kidney Diseases-claimed-Acute Kidney Injury', 'CD4-include-Renal Insufficiency, Chronic', 'Kidney Diseases-believed-Nephritis, Interstitial', 'Kidney Diseases-causes of-Kidney Failure, Chronic', 'Kidney Diseases-believed-Kidney Failure, Chronic', 'Kidney Diseases-caused-Prostaglandins', 'Icodextrin-associated-Death', 'Death-associated-Icodextrin', 'Diabetes Mellitus, Type 1-affect-INS', 'Diabetes Mellitus-affect-INS', 'Metabolic Syndrome-show-Ocular Hypertension', 'Glucose-show-Ocular Hypertension', 'Metabolic Syndrome-considered-Nervous System Diseases', 'INS-represent-Metabolic Syndrome', 'Neurologic Manifestations-involve-Polycystic Ovary Syndrome', 'Neurologic Manifestations-occur-Polycystic Ovary Syndrome', 'Neurologic Manifestations-have involve-INS', 'INS-considered-Nervous System Diseases', 'INS-occur-Polycystic Ovary Syndrome', 'Polycystic Ovary Syndrome-evaluated-Neurologic Manifestations', 'Polycystic Ovary Syndrome-evaluated-Cardiovascular Diseases', 'APOC1-evaluated-Neurologic Manifestations', 'APOC1-need-Neurologic Manifestations', 'APOC1-evaluated-Cardiovascular Diseases', 'Carotid Stenosis-delay-Dementia', 'Triglycerides-predict-Cardiovascular Diseases', 'Triglycerides-predict-Polycystic Ovary Syndrome', 'Lung Diseases-lower-TNF', 'Glucose-remove-Carotid Stenosis', 'Liver Diseases-lower-TNF', 'Peptic Ulcer-lower-TNF', 'Glucose-delay-Dementia', 'CRP-be predictors of-Death', 'ERCC2-associated-Xeroderma Pigmentosum', 'Xeroderma Pigmentosum-associated-ERCC2', 'Amyloidosis-show-Heart Diseases', 'TTR-show-Heart Diseases', 'Burkitt Lymphoma-occur-Lymphoma, B-Cell', 'Burkitt Lymphoma-shown-Lymphoma, B-Cell', 'MYC-associated-Burkitt Lymphoma', 'Burkitt Lymphoma-associated-MYC', 'Neoplasms-see-Plasmablastic Lymphoma', 'MYC-identified-Neoplasms', 'MYC-shown-Lymphoma, B-Cell', 'MYC-identified-Plasmablastic Lymphoma', 'MYC-see-Plasmablastic Lymphoma', 'Diabetes Mellitus-associated-H19', 'H19-associated-Diabetes Mellitus', 'Stroke-associated-H19', 'H19-associated-Stroke', 'Heart Diseases-associated-H19', 'H19-associated-Heart Diseases', 'INS-specific role on-Atrophy', 'Osteoarthritis-compared-Femoral Neck Fractures', 'TRPV1-related-Headache Disorders, Secondary', 'TRPV1-related-Pruritus', 'TRPV1-related-Neurogenic Inflammation', 'Glioblastoma-enrolled-MGMT', 'Glioma-enrolled-MGMT', 'Diabetes Mellitus-exert-Pancreatitis', 'Color Vision Defects-evaluate-Fatty Liver', 'Glucose-exert-Pancreatitis', 'Color Vision Defects-evaluate-Fibrosis', 'Color Vision Defects-evaluate-Neoplasms', 'CETP-associated-Dementia', 'Dementia-associated-CETP', 'Retinal Diseases-be in-Diabetes Mellitus', 'Retinal Diseases-include-INS', 'CETP-evaluate-Alzheimer Disease', 'rs5882-evaluate-Alzheimer Disease', 'Bacitracin-associated-Alzheimer Disease', 'Alzheimer Disease-associated-Bacitracin', 'Sclerosis-include-Dementia', 'Parkinson Disease-characterized-Neurodegenerative Diseases', 'LRRK2-associate-Parkinson Disease', 'Parkinson Disease-associate-LRRK2', 'LRRK2-characterized-Neurodegenerative Diseases', 'rs34637584-associate-Parkinson Disease', 'Parkinson Disease-associate-rs34637584', 'rs34637584-characterized-Neurodegenerative Diseases', 'LMNA-described-Progeria', 'MARCHF8-be in-Carcinogenesis', 'Glucose-associated-Diabetes Mellitus, Type 2', 'Diabetes Mellitus, Type 2-associated-Glucose', 'Inflammation-cause-INS', 'INS-disrupt-Aneurysm', 'DNMT3A-reported-Leukemia, Myeloid, Acute', 'DNMT3A-reported-Myelodysplastic Syndromes', 'Fatty Acids, Omega-3-decrease-Death', 'Fatty Acids, Omega-3-reduce-Diabetes Mellitus', 'Fatty Acids, Omega-3-reduce-Hypertension', 'WWP1-implicated-Neoplasms', 'WWP1-implicated-Communicable Diseases', 'WWP1-implicated-Heredodegenerative Disorders, Nervous System', 'Infections-continue-CRP', 'Atherosclerosis-include-Cholesterol', 'Cardiomegaly-include-Cholesterol', 'NFE2L2-referred-Fibrosis', 'NFE2L2-referred-Carcinogenesis', 'SHBG-predict-Cardiovascular Diseases', 'SHBG-predict-Death', 'Obesity, Abdominal-increase-Diabetes Mellitus, Type 1', 'Diabetes Mellitus, Type 1-reduce-Diabetes Mellitus', 'Obesity, Abdominal-increase-INS', 'Cerebral Small Vessel Diseases-resemble-Carotid Artery Injuries', 'Cerebral Small Vessel Diseases-resemble-Infarction', 'Cerebral Small Vessel Diseases-resemble-NOTCH3', 'Carotid Artery Injuries-caused-NOTCH3', 'Infarction-caused-NOTCH3', 'Leukoencephalopathies-be in-Hypertension', 'INS-involve-Diabetes Mellitus', 'TNF-released-Neoplasms', 'TNF-undetected-Alzheimer Disease', 'Doxorubicin-show efficacy response in-Leukemia, Myeloid, Acute', 'Doxorubicin-show-Drug-Related Side Effects and Adverse Reactions', 'Drug-Related Side Effects and Adverse Reactions-given-Leukemia, Myeloid, Acute', 'Drug-Related Side Effects and Adverse Reactions-given-Doxorubicin', 'Neurotoxicity Syndromes-contribute-Parkinson Disease', 'Retinal Degeneration-contribute-Parkinson Disease', 'GFAP-make-Neurotoxicity Syndromes', 'GFAP-contribute-Retinal Degeneration', 'TARDBP-tend-Sclerosis', 'GH1-include-Silver-Russell Syndrome', 'GH1-include-Osteochondrodysplasias', 'Diabetes Mellitus-characterize-INS', 'Neuroblastoma-demonstrate-Niemann-Pick Disease, Type A', 'Neurotoxicity Syndromes-accelerate-Neurodegenerative Diseases', 'Neuroblastoma-demonstrate-Ceramides', 'Ceramides-accelerate-Neurodegenerative Diseases', 'Memory Disorders-caused-Hypoxia', 'Valproic Acid-restore-Memory Disorders', 'Valproic Acid-caused-Hypoxia', 'Obesity, Abdominal-defined-Sarcopenia', 'Obesity, Abdominal-defined-LEP', 'Sarcopenia-defined-LEP', 'Dyslipidemias-impair-Chemical and Drug Induced Liver Injury', 'Obesity, Abdominal-link-LEP', 'LEP-link-Obesity, Abdominal', 'Fructose-cause-Dyslipidemias', 'Fructose-impair-Chemical and Drug Induced Liver Injury', 'LEP-link-Sarcopenia', 'Headache-observe-Cholesterol', 'Drug Resistant Epilepsy-carry-Alzheimer Disease', 'Drug Resistant Epilepsy-use-MAPT', 'Brain Injuries, Traumatic-associated-MAPT', 'MAPT-associated-Brain Injuries, Traumatic', 'Seizures-associated-MAPT', 'MAPT-associated-Seizures', 'Heart Failure-be with-Lisinopril', 'Diabetes Mellitus-overload-LRP2', 'Kidney Diseases-overload-LRP2', 'Metabolic Syndrome-supplemented-CRP', 'Back Pain-exhibit-Intervertebral Disc Degeneration', 'Back Pain-exhibit-SPARC', 'Blister-include-Choroiditis', 'HTRA1-induce-Choroiditis', 'HTRA1-include-Blister', 'HTRA1-show-Blister', 'LMNA-cause-Lipodystrophy', 'LMNA-cause-Muscular Diseases', 'Choroiditis-cause-Choroidal Neovascularization', 'HTRA1-cause-Choroiditis', 'HTRA1-be significant-Choroidal Neovascularization', 'Diabetes Mellitus-compare-Myotonic Dystrophy', 'Diabetes Mellitus-compare-Hypertrophy', 'Myotonic Dystrophy-compare-Hypertrophy', 'Diabetes Mellitus-compare-MMP13', 'MMP13-compare-Myotonic Dystrophy', 'MMP13-involved-Inflammation', 'MMP13-compare-Hypertrophy', 'MMP13-involved-Fibrosis', 'MMP13-be higher in-Myotonic Dystrophy', 'INS-reflect-Diabetes Mellitus, Type 2', 'Polysaccharides-raise-Pneumonia', 'Heart Failure-monitored-Heart Diseases', 'NPPA-occur-Heart Failure', 'NPPA-monitored-Heart Diseases', 'Heart Failure-develop-Amyloidosis', 'Cardiovascular Diseases-promote-INS', 'Heart Failure-induce-NPPA', 'NPPA-develop-Amyloidosis', 'Glucose-affected-Dementia', 'Alzheimer Disease-contain-MAPT', 'MAPT-contain-Nerve Degeneration', 'Metabolic Syndrome-associated-Cerebral Infarction', 'Cerebral Infarction-associated-Metabolic Syndrome', 'Hepatitis C-associated-Kidney Diseases', 'Kidney Diseases-associated-Hepatitis C', 'Triglycerides-associated-Metabolic Syndrome', 'Metabolic Syndrome-associated-Triglycerides', 'Triglycerides-associated-Cerebral Infarction', 'Cerebral Infarction-associated-Triglycerides', 'CD4-associated-Kidney Diseases', 'Kidney Diseases-associated-CD4', 'Kidney Diseases-followed-Glomerulonephritis', 'Nephrosis, Lipoid-followed-Kidney Diseases', 'Nephrosis, Lipoid-followed-Glomerulonephritis', 'Progeria-present-Stroke', 'Stroke-carry-rs267607649', 'Nephrosis, Lipoid-followed-CD79A', 'RECQL-represent-Neoplasms', 'Hypertension-show-Kidney Diseases', 'Multiple Myeloma-accompany by-Carpal Tunnel Syndrome', 'Diabetes Mellitus-show-Kidney Diseases', 'Multiple Myeloma-induced-TTR', 'Cholesterol-show-Kidney Diseases', 'Cholesterol-used-Drug-Related Side Effects and Adverse Reactions', 'Cholesterol-used-Neuroblastoma', 'Neuroblastoma-protect-Drug-Related Side Effects and Adverse Reactions', 'Cholesterol-protect-Neuroblastoma', 'Cholesterol-influence-Drug-Related Side Effects and Adverse Reactions', 'Cardiovascular Diseases-promote-Atherosclerosis', 'Hyponatremia-associated-Venlafaxine Hydrochloride', 'Venlafaxine Hydrochloride-associated-Hyponatremia', 'Cardiovascular Diseases-promote-Stroke', 'Cardiovascular Diseases-promote-Hypertension', 'NR3C2-promote-Cardiovascular Diseases', 'NR3C2-promote-Stroke', 'NR3C2-promote-Hypertension', 'FOXO3-promote-Neoplasms', 'FOXO3-promote-Heart Arrest', 'NR3C2-reduce-Myocardial Infarction', 'NR3C2-reduce-Stroke', 'NR3C2-reduce-Death', 'Venous Thromboembolism-require-Thrombosis', 'Epilepsy, Tonic-Clonic-contribute-Bone Diseases, Metabolic', 'Epilepsy, Tonic-Clonic-contribute-Osteoporosis', 'Venous Thromboembolism-require-Heparin, Low-Molecular-Weight', 'Bone Diseases, Metabolic-contribute-Hypoparathyroidism', 'GGH-be common In-Epilepsy, Tonic-Clonic', 'GGH-contribute to-Bone Diseases, Metabolic', 'GGH-contribute-Osteoporosis', 'Epilepsy, Absence-treated-Dementia', 'Breast Neoplasms-observed-Cardiotoxicity', 'Epilepsy, Absence-treated-Valproic Acid', 'Trastuzumab-combine-Anthracyclines', 'Cardiotoxicity-combine-Anthracyclines', 'Breast Neoplasms-benefit-Trastuzumab', 'Trastuzumab-observed-Cardiotoxicity', 'Neoplasms-lead-Neurodegenerative Diseases', 'PIN1-implicated-Neoplasms', 'PIN1-prevent-Neoplasms', 'PIN1-lead-Neurodegenerative Diseases', 'PIN1-implicated-Alzheimer Disease', 'Diabetes Mellitus-assessment of-INS', 'INS-be related to-Agnosia', 'Diabetes Mellitus-include-Kidney Diseases', 'Acute Kidney Injury-include-Kidney Diseases', 'Infections-include-Kidney Diseases', 'Alzheimer Disease-related-Fluorodeoxyglucose F18', 'Diabetes Mellitus-in presentation be-Kidney Diseases', 'Fluorodeoxyglucose F18-associated-Alzheimer Disease', 'Alzheimer Disease-associated-Fluorodeoxyglucose F18', 'Diabetes Mellitus-include-CD79A', 'Acute Kidney Injury-include-CD79A', 'Infections-include-CD79A', 'Kidney Diseases-include-CD79A', 'APOE-type-Diabetes Mellitus', 'NFKB1-be in-Neoplasms', 'Hypertension-associated-Atherosclerosis', 'Atherosclerosis-associated-Hypertension', 'Gastrointestinal Hemorrhage-increased-Ulcer', 'Gastrointestinal Hemorrhage-increased-PTGS2', 'Pneumonia-enhance-Inflammation', 'Doxorubicin-reduce-Cardiotoxicity', 'Bleomycin-enhance-Pneumonia', 'Bleomycin-enhance-Inflammation', 'Diabetes Mellitus-prescribe-INS', 'Cardiovascular Diseases-hear-Osteoporosis', 'HOXA4-decreased-Aortic Aneurysm, Abdominal', 'HOXA4-decreased-Aneurysm', 'Angina Pectoris-hear-Osteoporosis', 'Sclerosis-compared-APOE', 'Sclerosis-matched-APOE', 'Coronary Artery Disease-hear-Osteoporosis', 'Parkinson Disease-associated-Mitochondrial Diseases', 'Mitochondrial Diseases-associated-Parkinson Disease', 'KITLG-decreased-Alzheimer Disease', 'Heart Failure-hear-Osteoporosis', 'KITLG-associated-Alzheimer Disease', 'Alzheimer Disease-associated-KITLG', 'Peripheral Vascular Diseases-hear-Osteoporosis', 'Hypertension-hear-Osteoporosis', 'Asthma-hear-Osteoporosis', 'Neoplasms-hear-Osteoporosis', 'Back Pain-hear-Osteoporosis', 'Osteoporosis-hear-Thyroid Diseases', 'Cholesterol-hear-Osteoporosis', 'Lung Diseases-associated-Pulmonary Disease, Chronic Obstructive', 'Pulmonary Disease, Chronic Obstructive-associated-Lung Diseases', 'Chemical and Drug Induced Liver Injury-improve-Glucose', 'KL-remain-Vascular Calcification', 'KLK3-contribute to-Prostatic Neoplasms', 'KLK3-contribute to-Death', 'KLK3-screening for-Prostatic Neoplasms', 'KLK3-screening for-Neoplasms', 'KLK3-construct-Neoplasms', 'Glycerol-be safe and efficacious method of-Pain', 'TNFSF13-identified-Neoplasms', 'TNFSF13-define-Neoplasms', 'TNFSF13-define-Leukemia, Lymphocytic, Chronic, B-Cell', 'CHAT-decreased-Alzheimer Disease', 'CHAT-decreased-Dementia', 'BDNF-associated-Neurologic Manifestations', 'Neurologic Manifestations-associated-BDNF', 'BDNF-associated-Memory Disorders', 'Memory Disorders-associated-BDNF', 'Chronic Disease-characterized-INS', 'Diabetes Mellitus-be chronic disease-Glucose', 'Chronic Disease-characterized-Glucose', 'Huntington Disease-point out-HTT', 'Dementia-explored-Alzheimer Disease', 'TNF-explored-Alzheimer Disease', 'Death-protocols for-Diabetes Mellitus', 'Tauopathies-linked-MAPT', 'Cardiomyopathy, Dilated-caused-LMNA', 'Werner Syndrome-caused-LMNA', 'MAPT-linked-Dementia', 'MAPT-linked-Parkinson Disease, Secondary', 'PPARG-lead-Carcinoma, Acinar Cell', 'PPARG-lead-Meibomian Gland Dysfunction', 'Neuroblastoma-use-NQO1', 'VEGFA-increased-Glioblastoma', 'VEGFA-increased-Edema', 'Neurotoxicity Syndromes-caused-Parkinson Disease', 'Neurotoxicity Syndromes-caused-LRRK2', 'Neurotoxicity Syndromes-caused-rs34637584', 'Death-compare-KL', 'Stargardt Disease-caused-Neurologic Manifestations', 'Cholesterol-risk of-Coronary Artery Disease', 'Cholesterol-increase-Death', 'HIV Infections-demonstrate-Acquired Immunodeficiency Syndrome', 'HIV Infections-demonstrate-Death', 'HIV Infections-demonstrate-CD4', 'Astrocytoma-suggested-MTOR', 'Brain Neoplasms-suggested-MTOR', 'Hypertension-associated-Lupus Erythematosus, Systemic', 'Lupus Erythematosus, Systemic-associated-Hypertension', 'Kidney Diseases-be in-Lupus Erythematosus, Systemic', 'CYP11A1-show-Herpes Zoster', 'Genetic Diseases, Inborn-characterised-Neoplasms', 'INS-be related to-Metabolic Syndrome', 'WRN-give-Genetic Diseases, Inborn', 'WRN-characterised-Neoplasms', 'Osteoporosis-approved-Fractures, Bone', 'Denosumab-approved-Osteoporosis', 'Denosumab-approved-Fractures, Bone', 'Werner Syndrome-develop-Adenocarcinoma', 'Adenocarcinoma-develop-WRN', 'MSLN-present-Mesothelioma', 'MSLN-present-Lung Neoplasms', 'Diabetes Mellitus-cause-Atherosclerosis', 'TARDBP-play-Neurodegenerative Diseases', 'Diabetes Mellitus-concentrations of-INS', 'Diabetes Mellitus-treat-INS', 'TARDBP-play-Amyotrophic Lateral Sclerosis', 'Sclerosis-include-Alzheimer Disease', 'Sclerosis-be with-Torsades de Pointes', 'Renal Insufficiency, Chronic-associated-Acidosis', 'Acidosis-associated-Renal Insufficiency, Chronic', 'Diabetes Mellitus-generate-Tremor', 'Amnesia-like disease be-Alzheimer Disease', 'Retinal Degeneration-include-Alzheimer Disease', 'Diabetes Mellitus-deficiency of-INS', 'Diabetes Mellitus-generate-INS', 'Torsades de Pointes-include-Alzheimer Disease', 'Diabetes Mellitus-be common in-Myocardial Infarction', 'Osteoarthritis-cause-Hypertrophy', 'SIRT1-decrease with-Osteoarthritis', 'SIRT1-cause-Hypertrophy', 'Glucose-associate-Death', 'Death-associate-Glucose', 'Glucose-associate-Diabetes Mellitus', 'Diabetes Mellitus-associate-Glucose', 'Myocardial Infarction-comprise-Hyperglycemia', 'Glucose-comprise-Hyperglycemia', 'Hemorrhage-be in-Kidney Diseases', 'GHR-exhibit-Neoplasms', 'GHR-exhibit-Diabetes Mellitus', 'Williams Syndrome-derived-Neoplasms', 'WRN-derived-Williams Syndrome', 'Diabetes Mellitus-modify-INS', 'Diabetes Mellitus-involve-AGER', 'AGER-associated-Alzheimer Disease', 'Alzheimer Disease-associated-AGER', 'Metabolic Syndrome-predict-Cerebrovascular Disorders', 'Osteoporosis-decreased-Ascorbic Acid', 'Fractures, Bone-decreased-Ascorbic Acid', 'FGF19-associated-Aging, Premature', 'Aging, Premature-associated-FGF19', 'FGF19-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-FGF19', 'Sleep Apnea, Obstructive-include-Narcolepsy', 'PINK1-linked-Parkinson Disease, Secondary', 'Narcolepsy-started-Sodium Oxybate', 'Sodium Oxybate-include-Sleep Apnea, Obstructive', 'Sodium Oxybate-started-Sleep Apnea, Obstructive', 'Enalapril-reduce-Death', 'Enalapril-reduce-Death, Sudden', 'Dementia-found-Alzheimer Disease', 'Pain Insensitivity, Congenital-be in-Diabetes Mellitus', 'Triglycerides-associated-Pain Insensitivity, Congenital', 'Pain Insensitivity, Congenital-associated-Triglycerides', 'Cardiovascular Diseases-be in-Hypertension', 'Cardiovascular Diseases-prevent-Hypertension', 'Cardiovascular Diseases-treat-Diabetes Mellitus', 'PPARG-prevent-Cardiovascular Diseases', 'EPO-predict-Death', 'EPO-predict-Heart Failure', 'Neoplasms-modulate-Carcinogenesis', 'ING2-interact-Neoplasms', 'ING2-modulate-Carcinogenesis', 'Hypertension-show-Atherosclerosis', 'Glucose-develop-Acidosis', 'Diabetes Mellitus-show-Atherosclerosis', 'Atherosclerosis-show-Diabetic Nephropathies', 'Atherosclerosis-show-Cholesterol', 'Hypertension-determine-Vascular Calcification', 'Glucose-determine-Vascular Calcification', 'Celiac Disease-associated-Neoplasms', 'Neoplasms-associated-Celiac Disease', 'Celiac Disease-found-Neoplasms', 'Celiac Disease-associated-MLH1', 'MLH1-associated-Celiac Disease', 'Glucose-be in-Alzheimer Disease', 'Alzheimer Disease-bypass-Glucose Metabolism Disorders', 'Alzheimer Disease-improve-Ketosis', 'Glucose Metabolism Disorders-improve-Ketosis', 'Infections-reduced-Doxorubicin', 'Bacteremia-reduced-Doxorubicin', 'Alzheimer Disease-improve-INS', 'INS-bypass-Glucose Metabolism Disorders', 'INS-improve-Ketosis', 'Alzheimer Disease-improve-Glucose', 'Glucose-improve-Ketosis', 'Drug-Related Side Effects and Adverse Reactions-compare-Precursor Cell Lymphoblastic Leukemia-Lymphoma', 'Drug-Related Side Effects and Adverse Reactions-compare-Doxorubicin', 'Doxorubicin-compare-Precursor Cell Lymphoblastic Leukemia-Lymphoma', 'Neoplasms-considered-Pituitary Neoplasms', 'Neoplasms-considered-Prolactinoma', 'Neoplasms-considered-Pituitary Diseases', 'Abnormalities, Drug-Induced-considered-Pituitary Neoplasms', 'Abnormalities, Drug-Induced-considered-Prolactinoma', 'Abnormalities, Drug-Induced-considered-Pituitary Diseases', 'Hodgkin Disease-cause-Heart Failure', 'Breast Neoplasms-cause-Heart Failure', 'Dwarfism, Pituitary-considered-Pituitary Neoplasms', 'Anthracyclines-remain-Hodgkin Disease', 'Dwarfism, Pituitary-considered-Prolactinoma', 'Dwarfism, Pituitary-considered-Pituitary Diseases', 'Anthracyclines-remain-Breast Neoplasms', 'Neoplasms-be with-PRL', 'Anthracyclines-cause-Heart Failure', 'PRL-considered-Pituitary Neoplasms', 'PRL-considered-Prolactinoma', 'Cardiotoxicity-exist-Hypertension', 'PRL-considered-Pituitary Diseases', 'Cardiotoxicity-exist-Diabetes Mellitus', 'Heart Failure-exist-Hypertension', 'Heart Failure-exist-Diabetes Mellitus', 'Heart Failure-exist-Coronary Artery Disease', 'Heart Diseases-exist-Hypertension', 'Heart Diseases-exist-Diabetes Mellitus', 'Heart Diseases-exist-Coronary Artery Disease', 'Cardiotoxicity-be with-Anthracyclines', 'Cardiotoxicity-increased-Anthracyclines', 'Anthracyclines-exist-Hypertension', 'Anthracyclines-exist-Diabetes Mellitus', 'Anthracyclines-exist-Coronary Artery Disease', 'PLA2G3-marked inhibition of-Death', 'PLA2G3-produce-Death', 'PLA2G3-associated-Alzheimer Disease', 'Alzheimer Disease-associated-PLA2G3', 'RPS6KB1-play-Obesity', 'RPS6KB1-play-Diabetes Mellitus', 'RPS6KB1-play-Neoplasms', 'Diabetes Mellitus-increase-Alzheimer Disease', 'Diabetes Mellitus-control-Hypertension', 'Dementia-increase-Hypertension', 'Alzheimer Disease-increase-Hypertension', 'Alzheimer Disease-regulate-Nerve Degeneration', 'Alzheimer Disease-modulate-PLA2G3', 'Dementia, Vascular-increase-Hypertension', 'PLA2G3-regulate-Nerve Degeneration', 'Diabetes Mellitus-control-Cholesterol', 'Dementia-increase-Cholesterol', 'Alzheimer Disease-increase-Cholesterol', 'Dementia, Vascular-increase-Cholesterol', 'Inflammation-predict-Obesity', 'Pain-predict-Obesity', 'Obesity-double-Chronic Pain', 'Inflammation-predict TPI scores After-INS', 'MAPT-exhibit-Nerve Degeneration', 'Obesity-predict TPI scores After-INS', 'MAPT-produce-Memory Disorders', 'Myocardial Infarction-categorized-Metabolic Syndrome', 'Myocardial Infarction-categorized-Cholesterol', 'Leukoaraiosis-presence of-Hemorrhage', 'Hypertension-define-Diabetes Mellitus', 'Hypertension-taken-Diabetes Mellitus', 'Hypertension-define-Obesity', 'Diabetes Mellitus-taken-Obesity', 'Hypertension-define-Glucose', 'Glucose Metabolism Disorders-shown-Hyperglycemia', 'Glucose-taken-Diabetes Mellitus', 'Hyperglycemia-shown-VEGFA', 'Hypertension-define-Cholesterol', 'Cholesterol-taken-Diabetes Mellitus', 'Diabetes Mellitus-be with-Cataract', 'BMP6-accompanied-Urinary Bladder, Neurogenic', 'BMP6-accompanied-Alzheimer Disease', 'Fibrosis-result-Arrhythmias, Cardiac', 'MPO-cause-Fibrosis', 'MPO-result-Arrhythmias, Cardiac', 'Alzheimer Disease-characterized-Mitochondrial Diseases', 'Alzheimer Disease-characterized-Glucose', 'Cardiomyopathies-enhance-Inflammation', 'Inflammation-lead-Cardiomyopathies', 'Inflammation-lead-Arrhythmias, Cardiac', 'Cardiomyopathies-consequent reduce formation of-Lipoxins', 'Lipoxins-enhance-Inflammation', 'MDM2-target-Neoplasms', 'IDO1-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-IDO1', 'PIN1-play-Alzheimer Disease', 'PIN1-play-Neoplasms', 'PIN1-explain-Alzheimer Disease', 'PIN1-explain-Neoplasms', 'Pulmonary Embolism-include-Venous Thrombosis', 'Glucose-lead-Obesity', 'Hereditary Breast and Ovarian Cancer Syndrome-affect-Hypertrophy', 'Hereditary Breast and Ovarian Cancer Syndrome-associate-Dyslipidemias', 'Dyslipidemias-associate-Hereditary Breast and Ovarian Cancer Syndrome', 'Hereditary Breast and Ovarian Cancer Syndrome-associate-Glucose Intolerance', 'Glucose Intolerance-associate-Hereditary Breast and Ovarian Cancer Syndrome', 'Hereditary Breast and Ovarian Cancer Syndrome-associate-INS', 'INS-associate-Hereditary Breast and Ovarian Cancer Syndrome', 'Glucose Intolerance-be with-INS', 'Aortic Aneurysm, Thoracic-show-Asthma', 'Aortic Aneurysm, Thoracic-show-Phlebitis', 'Aortic Aneurysm, Thoracic-show-Inflammation', 'Aortic Aneurysm, Thoracic-show-CRP', 'SIRT3-block-Cardiomegaly', 'GGH-patients with-Congenital Abnormalities', 'GGH-live-Congenital Abnormalities', 'Infections-reported-Communicable Diseases', 'MME-decreased-Alzheimer Disease', 'MME-correlated-Alzheimer Disease', 'Xerostomia-prescribed-Desvenlafaxine Succinate', 'Constipation-prescribed-Desvenlafaxine Succinate', 'Non-alcoholic Fatty Liver Disease-investigate-Cardiovascular Diseases', 'GPT-investigate-Cardiovascular Diseases', 'Werner Syndrome-suggest-Carcinogenesis', 'Werner Syndrome-suggest-WRN', 'Adenocarcinoma-include-Pancreatic Neoplasms', 'Werner Syndrome-include-Pancreatic Neoplasms', 'Diabetes Mellitus-compounded-Malnutrition', 'Diabetes Mellitus-compounded-INS', 'SIRT1-suppress-Inflammation', 'APOE-investigate-Death', 'APOE-investigate-Malnutrition', 'Osteoarthritis-associated-Rheumatic Fever', 'Rheumatic Fever-associated-Osteoarthritis', 'Rheumatic Fever-associated-IL6', 'IL6-associated-Rheumatic Fever', 'Nerve Degeneration-linked-Neurodegenerative Diseases', 'Parkinson Disease-linked-Neurodegenerative Diseases', 'ALB-demonstrate-Diabetes Mellitus', 'ALB-demonstrate-Liver Diseases', 'ALB-demonstrate-Kidney Diseases', 'Muscular Diseases-associated-Dementia', 'Dementia-associated-Muscular Diseases', 'VCP-identified-Muscular Diseases', 'VCP-suffer-Muscular Diseases', 'VCP-identified-Dementia', 'VCP-associated-Dementia', 'Dementia-associated-VCP', 'SIRT1-constitute-Neurodegenerative Diseases', 'SIRT1-constitute-Glucose Metabolism Disorders', 'SIRT1-constitute-Cardiovascular Diseases', 'Drug-Related Side Effects and Adverse Reactions-attenuate-Heart Arrest', 'BMI1-targeted-Myositis', 'BMI1-targeted-Neoplasms', 'WRN-attenuate-Drug-Related Side Effects and Adverse Reactions', 'Blood Protein Disorders-modulate-Neurodegenerative Diseases', 'Drug-Related Side Effects and Adverse Reactions-modulate-Neurodegenerative Diseases', 'Aging, Premature-caused-rs58596362', 'Hyperinsulinism-development of-Hyperglycemia', 'Hyperinsulinism-prevent-Hyperglycemia', 'Hyperinsulinism-prevent development in-INS', 'INS-development of-Hyperglycemia', 'Sarcopenia-known-Atherosclerosis', 'Sarcopenia-related-Atherosclerosis', 'INS-include-Sarcopenia', 'INS-known-Atherosclerosis', 'INS-related-Atherosclerosis', 'ADIPOQ-associated-Diabetes Mellitus, Type 2', 'Diabetes Mellitus, Type 2-associated-ADIPOQ', 'Glucose Intolerance-detect-Diabetes Mellitus, Type 2', 'Glucose-detect-Diabetes Mellitus, Type 2', 'Dyslipidemias-receive-Heart Failure', 'Triglycerides-receive-Heart Failure', 'Respiratory Insufficiency-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-Respiratory Insufficiency', 'Brain Infarction-expressed-CHI3L1', 'CHI3L1-diminish in-Infarction', 'CHI3L1-expressed-Infarction', 'Heart Arrest-lead-Aneuploidy', 'CDKN2AIP-result-Heart Arrest', 'CDKN2AIP-result-Aneuploidy', 'Ascorbic Acid-reverse-Hypertriglyceridemia', 'Ascorbic Acid-reverse-Hyperglycemia', 'MAPK14-be with-Oculocerebrorenal Syndrome', 'Prostatic Hyperplasia-accompanied-Hypertension', 'VEGFA-accompanied-Hypertension', 'IL6-associated-Atherosclerosis', 'Atherosclerosis-associated-IL6', 'Glucose-reduce-Hypoglycemia', 'Glucose-reduce-Kidney Diseases', 'APOE-be besides-Alzheimer Disease', 'Cholesterol-increase-Dementia', 'Cardiotoxicity-range-Drug-Related Side Effects and Adverse Reactions', 'Cardiotoxicity-associated-Cetuximab', 'Cetuximab-associated-Cardiotoxicity', 'Cetuximab-range-Drug-Related Side Effects and Adverse Reactions', 'Cholesterol-increase-Cardiovascular Diseases', 'Neoplasms-identify-PPP2R5C', 'Metabolic Diseases-identify-PPP2R5C', 'Chronic Disease-overlap-Death', 'CD4-determine-HIV Infections', 'Coronary Artery Disease-contribute-Atherosclerosis', 'TNFRSF1A-associate-Coronary Artery Disease', 'Coronary Artery Disease-associate-TNFRSF1A', 'TNFRSF1A-contribute to-Atherosclerosis', 'Obesity-improve-Triglycerides', 'VDR-associated-Neoplasms', 'Neoplasms-associated-VDR', 'VDR-associated-Arbovirus Infections', 'Arbovirus Infections-associated-VDR', 'VDR-associated-Autoimmune Diseases', 'Autoimmune Diseases-associated-VDR', 'FTO-expressed-Obesity', 'Neoplasms-be uncommon in-GHR', 'Diabetes Mellitus-be uncommon in-GHR', 'Cholesterol-include-Cardiomyopathies', 'Obesity-develop-Glucose', 'Obesity, Maternal-develop-Glucose', 'Sepsis-include-Inflammation', 'Arthritis-include-Inflammation', 'Inflammation-be in-Neoplasms', 'Fatty Liver-associated-Weight Loss', 'Weight Loss-associated-Fatty Liver', 'Osteoporosis-maintain-Colorectal Neoplasms', 'Fractures, Bone-maintain-Colorectal Neoplasms', 'Infections-maintain-Colorectal Neoplasms', 'Cardiovascular Diseases-maintain-Colorectal Neoplasms', 'Calcifediol-maintain-Colorectal Neoplasms', 'Calcifediol-prevent-Colorectal Neoplasms', 'Calcifediol-maintain-Osteoporosis', 'Calcifediol-prevent-Osteoporosis', 'Calcifediol-maintain-Fractures, Bone', 'Calcifediol-prevent-Fractures, Bone', 'Calcifediol-maintain-Infections', 'Calcifediol-prevent-Infections', 'Calcifediol-maintain-Cardiovascular Diseases', 'Calcifediol-prevent-Cardiovascular Diseases', 'BDNF-regulate-Alzheimer Disease', 'BDNF-associated-Neurodegenerative Diseases', 'Neurodegenerative Diseases-associated-BDNF', 'BDNF-regulate-Neurodegenerative Diseases', 'Inflammation-termed-Obesity', 'Carcinogenesis-termed-Obesity', 'Overnutrition-termed-Obesity', 'INS-termed-Obesity', 'Dementia-associated-IL6', 'IL6-associated-Dementia', 'rs1333049-tagge-Dementia', 'Neurogenic Inflammation-confer-Glutathione', 'Glutathione-confer-Neurodegenerative Diseases', 'Osteomalacia-be with-Osteoporotic Fractures', 'VDR-bind-Calcitriol', 'VDR-generate-Osteoporotic Fractures', 'Calcitriol-generate-Osteoporotic Fractures', 'Skin Diseases-illuminate-VDR', 'Neoplasms-illuminate-VDR', 'Cardiovascular Diseases-associated-Metabolic Diseases', 'Metabolic Diseases-associated-Cardiovascular Diseases', 'Retinal Diseases-develop-Retinal Degeneration', 'Retinal Diseases-develop-Lipofuscin', 'Arthritis, Rheumatoid-use-Death', 'Arthritis, Rheumatoid-replicate-Death', 'Arthritis, Rheumatoid-use-TRAF1', 'ADIPOQ-associated-Heart Failure', 'Heart Failure-associated-ADIPOQ', 'BDNF-support-Dementia', 'ADIPOQ-correlated-Cardiovascular Diseases', 'ADIPOQ-correlated-Death', 'ADIPOQ-be in-Heart Failure', 'SOST-determine-Hip Fractures', 'Relaxin-cure-Heart Failure', 'Relaxin-cure-Fibrosis', 'Glycosaminoglycans-observed-Osteoarthritis', 'Diabetes Mellitus, Type 2-associated-Insulin Resistance', 'Insulin Resistance-associated-Diabetes Mellitus, Type 2', 'Diabetes Mellitus, Type 2-associated-Nerve Degeneration', 'Nerve Degeneration-associated-Diabetes Mellitus, Type 2', 'IAPP-associated-Insulin Resistance', 'Insulin Resistance-associated-IAPP', 'Docosahexaenoic Acids-associated-Vision Disorders', 'Vision Disorders-associated-Docosahexaenoic Acids', 'Docosahexaenoic Acids-associated-Neurodegenerative Diseases', 'Neurodegenerative Diseases-associated-Docosahexaenoic Acids', 'Diabetes Mellitus-include-Anemia', 'Diabetes Mellitus-include-Hypocalcemia', 'Diabetes Mellitus-include-Hyperphosphatemia', 'Hypertension-include-Anemia', 'Hypertension-include-Hypocalcemia', 'Hypertension-include-Hyperphosphatemia', 'Coronary Artery Disease-include-Anemia', 'Coronary Artery Disease-include-Hypocalcemia', 'Coronary Artery Disease-include-Hyperphosphatemia', 'Coronary Artery Disease-include-Hyperparathyroidism', 'Heart Failure-include-Anemia', 'Heart Failure-include-Hypocalcemia', 'Heart Failure-include-Hyperphosphatemia', 'Heart Failure-include-Hyperparathyroidism', 'Neoplasms-exhibit-Necrosis', 'Neoplasms-express-SDC1', 'Necrosis-express-SDC1', 'Cerebrovascular Disorders-include-Anemia', 'Cerebrovascular Disorders-include-Hypocalcemia', 'Cerebrovascular Disorders-include-Hyperphosphatemia', 'Cerebrovascular Disorders-include-Hyperparathyroidism', 'Peripheral Vascular Diseases-include-Anemia', 'Peripheral Vascular Diseases-include-Hypocalcemia', 'Peripheral Vascular Diseases-include-Hyperphosphatemia', 'Peripheral Vascular Diseases-include-Hyperparathyroidism', 'Chronic Disease-evaluated-Atherosclerosis', 'Chronic Disease-evaluated-Neoplasms', 'Hypocalcemia-include-Neoplasms', 'Chronic Disease-evaluated-Prostatitis', 'Hyperphosphatemia-include-Neoplasms', 'Hyperparathyroidism-include-Neoplasms', 'Chronic Disease-evaluated-Osteoporosis', 'Anemia-include-Renal Insufficiency, Chronic', 'Chronic Disease-evaluated-Parkinson Disease', 'Chronic Disease-evaluated-Retinal Degeneration', 'Hypocalcemia-include-Renal Insufficiency, Chronic', 'Hyperphosphatemia-include-Renal Insufficiency, Chronic', 'Diabetes Mellitus-prevent-Hypotension', 'Diabetes Mellitus-prevent-Heart Failure', 'Hyperparathyroidism-include-Renal Insufficiency, Chronic', 'Dyslipidemias-prevent-Hypotension', 'Dyslipidemias-improve-Heart Failure', 'Hypotension-prevent-Metabolic Syndrome', 'Heart Failure-prevent-Metabolic Syndrome', 'INS-improve-Dyslipidemias', 'INS-prevent-Hypotension', 'INS-improve-Heart Failure', 'Cholesterol-include-Anemia', 'Chronic Disease-evaluated-INS', 'Cholesterol-include-Hypocalcemia', 'Cholesterol-include-Hyperphosphatemia', 'Diabetes Mellitus, Type 2-require-Hypoglycemia', 'Rothmund-Thomson Syndrome-aimed-Osteosarcoma', 'Rothmund-Thomson Syndrome-optimize-Osteosarcoma', 'Rothmund-Thomson Syndrome-exploit-RECQL4', 'RECQL4-aimed-Osteosarcoma', 'RECQL4-optimize-Osteosarcoma', 'Hypertension-recommended-Diabetes Mellitus', 'ACE-recommended-Diabetes Mellitus', 'ENO2-decrease in-Alzheimer Disease', 'Diabetic Nephropathies-recommended-ACE', 'ACE-recommended-Kidney Diseases', 'Neurodegenerative Diseases-play-CREBBP', 'RECQL4-result-Growth Disorders', 'GLO1-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-GLO1', 'GLO1-associated-Neoplasms', 'Neoplasms-associated-GLO1', 'AGER-implicated-Chronic Disease', 'GLO1-play-Neoplasms', 'Docosahexaenoic Acids-correlated-Alzheimer Disease', 'Cardiovascular Diseases-promote-Inflammation', 'Docosahexaenoic Acids-correlated-Coronary Artery Disease', 'CYP11B2-contribute-Cardiovascular Diseases', 'CYP11B2-promote-Inflammation', 'Docosahexaenoic Acids-found-Alzheimer Disease', 'Fatty Acids, Omega-3-prevent-Dementia, Vascular', 'Fatty Acids, Omega-3-prevent-Inflammation', 'Fatty Acids, Omega-3-prevent-Thrombosis', 'Docosahexaenoic Acids-prevent-Cardiovascular Diseases', 'Alzheimer Disease-pattern of-Atrophy', 'Alzheimer Disease-present-Atrophy', 'Alzheimer Disease-pattern of-Gentamicins', 'Alzheimer Disease-present-Gentamicins', 'Heart Failure-require-Anemia', 'APOE-show-Glucose Metabolism Disorders', 'APOE-affected-Alzheimer Disease', 'Immunologic Deficiency Syndromes-associated-Mitochondrial Encephalomyopathies', 'Mitochondrial Encephalomyopathies-associated-Immunologic Deficiency Syndromes', 'Immunologic Deficiency Syndromes-devastate-Mitochondrial Encephalomyopathies', 'Immunologic Deficiency Syndromes-associated-Cardiomyopathies', 'Cardiomyopathies-associated-Immunologic Deficiency Syndromes', 'Immunologic Deficiency Syndromes-devastate-Cardiomyopathies', 'Immunologic Deficiency Syndromes-associated-Heredodegenerative Disorders, Nervous System', 'Heredodegenerative Disorders, Nervous System-associated-Immunologic Deficiency Syndromes', 'COX8A-associated-Mitochondrial Encephalomyopathies', 'Mitochondrial Encephalomyopathies-associated-COX8A', 'COX8A-devastate-Mitochondrial Encephalomyopathies', 'COX8A-associated-Cardiomyopathies', 'Cardiomyopathies-associated-COX8A', 'COX8A-devastate-Cardiomyopathies', 'Weight Gain-associated-Metabolic Syndrome', 'Metabolic Syndrome-associated-Weight Gain', 'COX8A-associated-Heredodegenerative Disorders, Nervous System', 'Heredodegenerative Disorders, Nervous System-associated-COX8A', 'Weight Gain-associated-Kidney Failure, Chronic', 'Kidney Failure, Chronic-associated-Weight Gain', 'Kidney Failure, Chronic-related-Hypertension', 'Glucose-associated-Insulin Resistance', 'Insulin Resistance-associated-Glucose', 'Fatty Acids-utilize-Glucose', 'Diabetes Mellitus-utilize-Glucose', 'Coronary Artery Disease-utilize-Glucose', 'Diabetes Mellitus-appear-Fatty Acids', 'Nerve Degeneration-exacerbated-Drug-Related Side Effects and Adverse Reactions', 'Nerve Degeneration-exacerbated-SOD1', 'Drug-Related Side Effects and Adverse Reactions-exacerbated-SOD1', 'HIV Infections-cause-Mitochondrial Diseases', 'Nucleosides-treat-HIV Infections', 'Nucleosides-cause-Mitochondrial Diseases', 'Heart Failure-coexist-Diabetes Mellitus', 'Fasciculation-intercalating-Phospholipids', 'Heart Failure-coexist-Hypertension', 'Inflammation-intercalating-Phospholipids', 'Heart Failure-be complex disease-Metabolic Diseases', 'Heart Failure-manifest-Metabolic Diseases', 'Diabetes Mellitus-manifest-Metabolic Diseases', 'Hypertension-manifest-Metabolic Diseases', 'INS-utilize-Fatty Acids', 'Heart Failure-coexist-INS', 'INS-manifest-Metabolic Diseases', 'Heart Failure-utilize-Fatty Acids', 'Diabetes Mellitus-utilize-Fatty Acids', 'Hypertension-utilize-Fatty Acids', 'Metabolic Diseases-utilize-Fatty Acids', 'Diabetes Mellitus-develop-Obesity', 'Diabetes Mellitus-develop-Glucose', 'CRP-compared-Tuberculosis, Lymph Node', 'CRP-compared-Lymphoma', 'Edema-result-Retinal Vein Occlusion', 'Bevacizumab-compare-Edema', 'Bevacizumab-compare-Retinal Vein Occlusion', 'Bevacizumab-result-Retinal Vein Occlusion', 'Heart Failure-associated-Ventricular Dysfunction, Left', 'Ventricular Dysfunction, Left-associated-Heart Failure', 'Heart Failure-include-Ventricular Dysfunction, Left', 'Death-be in-Ventricular Dysfunction, Left', 'Heart Failure-include-ACE', 'Death-include-ACE', 'Ventricular Dysfunction, Left-include-ACE', 'Bevacizumab-antibody against-VEGFA', 'Thromboembolism-receive-Bevacizumab', 'Bevacizumab-receive-Heart Diseases', 'Glucose-examine-Cardiovascular Diseases', 'Glucose Intolerance-undergo MRI assessment In-Atherosclerosis', 'Diabetes Mellitus-undergo MRI assessment In-Atherosclerosis', 'Glucose-undergo MRI assessment In-Atherosclerosis', 'Diabetes Mellitus-be with-Myocardial Infarction', 'Fructose-correlate-Diabetes Mellitus', 'Inflammation-increase-Intervertebral Disc Degeneration', 'Fructose-correlate-Myocardial Infarction', 'Insulin Glargine-report-Myoclonus', 'Inflammation-accompany-Intervertebral Disc Degeneration', 'Inflammation-increase-Low Back Pain', 'Intervertebral Disc Degeneration-contribute-Low Back Pain', 'Intervertebral Disc Degeneration-increase-Ascorbic Acid', 'Inflammation-increase-Ascorbic Acid', 'Ascorbic Acid-increase-Intervertebral Disc Degeneration', 'Ascorbic Acid-increase-Low Back Pain', 'Coronary Artery Disease-including-Cardiovascular Diseases', 'Angina Pectoris-including-Cardiovascular Diseases', 'Myocardial Infarction-including-Cardiovascular Diseases', 'Stroke-including-Cardiovascular Diseases', 'Hypotension-increased-Diabetes Mellitus', 'Hypotension-increased-Myocardial Infarction', 'Fructosamine-increased-Diabetes Mellitus', 'Hypertension-randomize-Lisinopril', 'Breast Neoplasms-develop-Amenorrhea', 'Amenorrhea-develop-Infertility, Female', 'Doxorubicin-develop-Amenorrhea', 'Diabetes Mellitus, Type 2-deregulated-AKT1', 'Neoplasms-deregulated-AKT1', 'Hyaluronic Acid-injected-Pain', 'Hyaluronic Acid-injected-Osteoarthritis', 'Hypoxia-found-Lung Injury', 'Peripheral Nervous System Diseases-include-Heart Diseases', 'CLU-implicated-Diabetes Mellitus', 'CLU-implicated-Atherosclerosis', 'Peripheral Nervous System Diseases-include-Lipodystrophy', 'LMNA-suffering-Muscular Dystrophy, Emery-Dreifuss', 'LMNA-suffering-Muscular Dystrophies, Limb-Girdle', 'CLU-implicated-Neurodegenerative Diseases', 'Sarcopenia-lead-Parkinson Disease', 'LMNA-suffering-Lipodystrophy', 'Muscle Weakness-associated-Parkinson Disease', 'Parkinson Disease-associated-Muscle Weakness', 'Fatigue-associated-Parkinson Disease', 'Parkinson Disease-associated-Fatigue', 'IL6-involved-Sarcopenia', 'IL6-associated-Parkinson Disease', 'Parkinson Disease-associated-IL6', 'Dyslipidemias-emerge-Metabolic Syndrome', 'Hypertension-emerge-Metabolic Syndrome', 'INS-emerge-Metabolic Syndrome', 'Friedreich Ataxia-caused-FXN', 'Neurodegenerative Diseases-caused-FXN', 'Hyperhomocysteinemia-lack-Hyperlipidemias', 'Parkinson Disease-influence-Neurotoxicity Syndromes', 'Neurotoxicity Syndromes-protect-Parkinson Disease', 'MAPT-reflect-Basal Ganglia Diseases', 'MAPT-reflect-Alzheimer Disease', 'Neoplasms-shown-Prostatic Neoplasms', 'Neoplasms-induce-Prostatic Neoplasms', 'Prostatic Neoplasms-shown-AR', 'Obesity, Abdominal-accompany-Metabolic Diseases', 'INS-elevated-Obesity, Abdominal', 'INS-elevated-Metabolic Diseases', 'INS-accompany-Metabolic Diseases', 'INS-lead-Hypertension', 'INS-lead-Cardiovascular Diseases', 'SIRT1-suppress-Cardiovascular Diseases', 'Multiple Sclerosis-develop-Central Nervous System Neoplasms', 'Multiple Sclerosis-receive-Natalizumab', 'Central Nervous System Neoplasms-receive-Natalizumab', 'Mitochondrial Diseases-implicated-Metabolic Diseases', 'Mitochondrial Diseases-implicated-Obesity', 'Mitochondrial Diseases-implicated-Diabetes Mellitus', 'Metabolic Diseases-characterized-Obesity', 'Metabolic Diseases-characterized-Diabetes Mellitus', 'Ischemia-observed-Ischemic Attack, Transient', 'GJA1-observed-Ischemic Attack, Transient', 'GJA1-observed-Ischemia', 'MECP2-demonstrate-Death', 'Alzheimer Disease-begin-Extranodal Extension', 'Alzheimer Disease-occur-Muscle Rigidity', 'FGF7-result-Blister', 'RBP4-detect-Cardiovascular Diseases', 'Alzheimer Disease-occur-Tremor', 'RBP4-detect-Metabolic Syndrome', 'Neurodegenerative Diseases-occur-Muscle Rigidity', 'Neurodegenerative Diseases-occur-Nerve Degeneration', 'GGH-base-Dwarfism, Pituitary', 'Extranodal Extension-occur-Nerve Degeneration', 'Muscle Rigidity-occur-Nerve Degeneration', 'Tremor-occur-Nerve Degeneration', 'Alzheimer Disease-begin-MAPT', 'MAPT-occur-Nerve Degeneration', 'Hyperthyroidism-be present-Hypothyroidism', 'Hyperthyroidism-be present-Thyrotropin', 'Hyperthyroidism-be with-Thyrotropin', 'Ascorbic Acid-decrease-Werner Syndrome', 'Ascorbic Acid-up-regulated-Werner Syndrome', 'Ascorbic Acid-increase-Neoplasms', 'Ascorbic Acid-involved-Obesity', 'PTEN-cause-Primary Ovarian Insufficiency', 'Obesity-include-Kidney Diseases', 'Coronary Artery Disease-include-Kidney Diseases', 'Cerebrovascular Disorders-include-Kidney Diseases', 'Peripheral Arterial Disease-include-Kidney Diseases', 'Heart Failure-include-Kidney Diseases', 'Diabetes Mellitus-include-CST3', 'Hypertension-include-CST3', 'Obesity-include-CST3', 'Coronary Artery Disease-include-CST3', 'Cerebrovascular Disorders-include-CST3', 'Peripheral Arterial Disease-include-CST3', 'Heart Failure-include-CST3', 'Obesity-influence-INS', 'Inflammation-influence-INS', 'Colorectal Neoplasms-observed-Neoplasms', 'CDKN1A-associated-Colorectal Neoplasms', 'Colorectal Neoplasms-associated-CDKN1A', 'CDKN1A-associated-Death', 'Death-associated-CDKN1A', 'CDKN1A-use-Colorectal Neoplasms', 'CDKN1A-observed-Colorectal Neoplasms', 'CDKN1A-observed-Neoplasms', 'Calcitriol-predict In-Chronic Disease', 'Heart Failure-predict-Calcitriol', 'Calcitriol-predict-Death', 'ADIPOQ-predict-Death', 'ADIPOQ-predict-Cardiovascular Diseases', 'Dementia-use-Alzheimer Disease', 'Dementia-use-APOE', 'Leukemia, Myeloid, Acute-pointed-CDKN2A', 'Osteoporosis-include-Chronic Disease', 'Autoimmune Diseases-include-Chronic Disease', 'Hypertension-include-Chronic Disease', 'Adrenal Insufficiency-associated-Multiple Sclerosis', 'Multiple Sclerosis-associated-Adrenal Insufficiency', 'Atherosclerosis-include-Chronic Disease', 'Muscle Weakness-include-Chronic Disease', 'Adrenal Insufficiency-associated-Parkinson Disease', 'Parkinson Disease-associated-Adrenal Insufficiency', 'Dyslipidemias-be in-Renal Insufficiency, Chronic', 'Dyslipidemias-remain-Triglycerides', 'Renal Insufficiency, Chronic-remain-Triglycerides', 'Calcifediol-associated-Chronic Disease', 'Chronic Disease-associated-Calcifediol', 'Calcifediol-associated-Osteoporosis', 'Osteoporosis-associated-Calcifediol', 'Calcifediol-associated-Neoplasms', 'Neoplasms-associated-Calcifediol', 'Calcifediol-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-Calcifediol', 'Calcifediol-associated-Autoimmune Diseases', 'Autoimmune Diseases-associated-Calcifediol', 'Calcifediol-associated-Hypertension', 'Hypertension-associated-Calcifediol', 'Calcifediol-associated-Atherosclerosis', 'Atherosclerosis-associated-Calcifediol', 'Endocrine System Diseases-increase-Neoplasms', 'Endocrine System Diseases-raised-GGH', 'Calcifediol-associated-Muscle Weakness', 'Muscle Weakness-associated-Calcifediol', 'GGH-increase-Neoplasms', 'Dwarfism, Pituitary-increase-Glucose Metabolism Disorders', 'Dwarfism, Pituitary-increase-Glucose', 'Osteoporosis-defined-Sodium Dodecyl Sulfate', 'Obesity-accelerate-Atherosclerosis', 'Hyperparathyroidism, Secondary-consist-VDR', 'Renal Insufficiency, Chronic-consist-VDR', 'Diabetes Mellitus-accelerate-Atherosclerosis', 'Hyperlipidemias-accelerate-Atherosclerosis', 'Hypertension-accelerate-Atherosclerosis', 'INS-accelerate-Atherosclerosis', 'Valproic Acid-control-Psychomotor Agitation', 'Valproic Acid-used-Psychomotor Agitation', 'Valproic Acid-control-Dementia', 'Valproic Acid-used-Dementia', 'Infections-treated-Psychomotor Agitation', 'Infections-treated-Valproic Acid', 'Psychomotor Agitation-included-Infections', 'Psychomotor Agitation-apply-Valproic Acid', 'Psychomotor Agitation-included-Gastrointestinal Diseases', 'Valproic Acid-included-Infections', 'Valproic Acid-included-Gastrointestinal Diseases', 'Valproic Acid-recommended-Psychomotor Agitation', 'Valproic Acid-recommended-Dementia', 'Cholesterol-lowering-Coronary Artery Disease', 'Cholesterol-target-Death', 'CISD2-lead-Blindness', 'CISD2-lead-Muscular Atrophy', 'Inflammation-predict-Atrial Fibrillation', 'CISD2-code-Wolfram Syndrome', 'CISD2-code-Optic Atrophy', 'CISD2-code-Diabetes Mellitus', 'CISD2-code-Deafness', 'Atrial Fibrillation-predict-Myocardial Infarction', 'CRP-predict-Atrial Fibrillation', 'CRP-associate-Myocardial Infarction', 'Myocardial Infarction-associate-CRP', 'CRP-associate-Stroke', 'Stroke-associate-CRP', 'Adrenal Insufficiency-implicate-Metabolic Syndrome', 'CRAT-implicate-Metabolic Syndrome', 'APOE-association between-Stroke', 'Shock-protect-Death', 'HSPB1-protect-Death', 'Pain Insensitivity, Congenital-observed-Basal Ganglia Diseases', 'Alzheimer Disease-precede-Macular Degeneration', 'LMNB1-be useful biomarker for-Carcinoma, Hepatocellular', 'Macular Degeneration-spread of-MAPT', 'Macular Degeneration-precede-MAPT', 'LMNB1-be useful biomarker in-Neoplasms', 'MAPT-colocalized-Muscular Dystrophies', 'Diabetes Mellitus-initiate-Hypoglycemia', 'Docosahexaenoic Acids-associated-Nervous System Diseases', 'Nervous System Diseases-associated-Docosahexaenoic Acids', 'INS-initiate-Diabetes Mellitus', 'Renal Insufficiency-pre-existing by-Kidney Diseases', 'Renal Insufficiency-cause-Muscular Diseases', 'Cockayne Syndrome-lead-Shy-Drager Syndrome', 'Renal Insufficiency-use-Gout', 'Kidney Diseases-cause-Muscular Diseases', 'Pancytopenia-cause-Muscular Diseases', 'Muscular Diseases-combine-Gout', 'KMT2A-amplification of be-Myelodysplastic Syndromes', 'AGER-bind-Hyperglycemia', 'AGER-linked-Hyperglycemia', 'HMOX1-surround-Cerebral Infarction', 'AGER-linked-Neurodegenerative Diseases', 'HMOX1-surround-Hemorrhage', 'AGER-linked-Neoplasms', 'HMOX1-be up regulated within-Multiple Sclerosis', 'HMOX1-surround-Multiple Sclerosis', 'HMOX1-up-regulated-Central Nervous System Diseases', 'Seizures-present-KMT2A', 'Hyperkinesis-promote-Alzheimer Disease', 'Hyperkinesis-promote-Parkinson Disease', 'Hyperkinesis-contribute-Neurodegenerative Diseases', 'Cataract-suffer-Diabetes Mellitus', 'Diabetes Mellitus-linked-Mitochondrial Diseases', 'PON1-measure-Diabetes Mellitus', 'Alzheimer Disease-meet-Death', 'GBA-meet-Alzheimer Disease', 'GBA-meet-Death', 'ZEB2-expressed-Neoplasms', 'ZEB2-expressed-Breast Neoplasms', 'ZEB2-expressed-Stomach Neoplasms', 'ZEB2-expressed-Pancreatic Neoplasms', 'ZEB2-occupy-Carcinogenesis', 'Genetic Diseases, Inborn-cause-WRN', 'APOE-examine-Death', 'Ankylosis-identified-Chondrocalcinosis', 'ANKH-identified-Chondrocalcinosis', 'Obesity-lead-Fatty Liver', 'Obesity, Abdominal-implicate-Diabetes Mellitus', 'Obesity, Abdominal-implicate-Cardiovascular Diseases', 'Obesity, Abdominal-implicate-Metabolic Syndrome', 'Obesity, Abdominal-implicate-Death', 'Obesity, Abdominal-implicate-INS', 'APOE-associated-Hypertension', 'Hypertension-associated-APOE', 'APOE-associated-Stroke', 'Stroke-associated-APOE', 'CLU-represent-Neoplasms', 'CLU-represent-Atherosclerosis', 'CLU-represent-Diabetes Mellitus', 'CLU-represent-Kidney Diseases', 'Infections-associated-CRP', 'CRP-associated-Infections', 'CDH1-prove-Dermatofibrosarcoma', 'Ischemia-compare-Hemorrhage', 'Ischemia-treated-Heparin', 'Heart Diseases-be with-Amyloidosis', 'Heart Diseases-differentiate-Amyloidosis', 'Glucose-study-Diabetes Mellitus', 'Heart Diseases-be with-TTR', 'Heart Diseases-differentiate-TTR', 'Glucose-study-Hypertension', 'Neoplasms-seen-Hypotension', 'Neoplasms-seen-Cholesterol', 'Glucose-needed-Ossification of Posterior Longitudinal Ligament', 'Polycythemia Vera-lead-Epilepsy', 'Infliximab-lead-Epilepsy', 'Death-include-Peritoneal Neoplasms', 'AGER-implicated-Alzheimer Disease', 'Immunologic Deficiency Syndromes-cause-Hyperparathyroidism', 'Immunologic Deficiency Syndromes-cause-LEP', 'Hyperparathyroidism-cause-LEP', 'Death-predicted-INS', 'PTH-observe-Chronic Disease', 'PTH-provide-Death', 'Cerebral Hemorrhage-be with-Amyloidosis', 'Genetic Diseases, Inborn-include-Neoplasms', 'Genetic Diseases, Inborn-associated-Breast Neoplasms', 'Breast Neoplasms-associated-Genetic Diseases, Inborn', 'Genetic Diseases, Inborn-include-Breast Neoplasms', 'WRN-lead-Genetic Diseases, Inborn', 'Stroke-increase-Gastrointestinal Hemorrhage', 'Atorvastatin-reduce-Stroke', 'Atorvastatin-increase-Gastrointestinal Hemorrhage', 'Adenocarcinoma of Lung-show-Neoplasms', 'Adenocarcinoma of Lung-show-VEGFA', 'Hypotension-increased-Cataract', 'Infections-based-Pneumococcal Infections', 'Infections-based-Polysaccharides', 'BMP7-induce-Breast Neoplasms', 'BMP7-induce-Death', 'SIRT1-protect neurons from-Nerve Degeneration', 'SIRT1-protect-Neurodegenerative Diseases', 'Diabetes Mellitus-studied-Death', 'Diabetes Mellitus-genotyped-SIRT1', 'SIRT1-studied-Death', 'SIRT1-increase-Death', 'Glutathione-play-Neoplasms', 'Glutathione-play-Cystic Fibrosis', 'Glutathione-manifest-Neoplasms', 'Glutathione-play-Neurodegenerative Diseases', 'Glutathione-manifest-Parkinson Disease', 'Glutathione-manifest-Alzheimer Disease', 'Glutathione-implicated-Cystic Fibrosis', 'Glutathione-implicated-Neurodegenerative Diseases', 'Coronary Artery Disease-observed-Cholesterol', 'Death-observed-Cholesterol', 'Cholesterol-histories of-Hypertension', 'RETN-associated-Calcinosis', 'Calcinosis-associated-RETN', 'Inflammation-converge-Neoplasms', 'Inflammation-converge-TP53', 'TP53-provide-Neoplasms', 'Hyperglycemia-accelerate-Aneurysm', 'MAPT-lead-Aneurysm', 'TP53-provide-Death', 'Fatigue-explained-CRP', 'Seizures-related-Fatigue', 'FLCN-contribute-Emphysema', 'Pulmonary Disease, Chronic Obstructive-genotype-Pneumothorax', 'Cardiovascular Diseases-indicated-Cholesterol', 'Osteoporosis-indicated-Cholesterol', 'CRP-play-Cardiovascular Diseases', 'Muscular Dystrophy, Duchenne-predict-Death', 'SIRT1-decreased-Alzheimer Disease', 'INS-stimulate-Diabetes Mellitus', 'TP53-result-Hyperpigmentation', 'CRP-associated-Virilism', 'Virilism-associated-CRP', 'Bevacizumab-directed-VEGFA', 'VEGFA-increase-Drug-Related Side Effects and Adverse Reactions', 'VEGFA-increase-Lung Neoplasms', 'Bevacizumab-increase-Drug-Related Side Effects and Adverse Reactions', 'Bevacizumab-increase-Lung Neoplasms', 'INS-self-adjust-Diabetes Mellitus', 'Hypotension-achieve-Diabetes Mellitus', 'SHBG-associated-Alzheimer Disease', 'Alzheimer Disease-associated-SHBG', 'SHBG-associated-Dementia', 'Dementia-associated-SHBG', 'Teriparatide-reduce-Fractures, Bone', 'Teriparatide-reduce-Osteoporosis', 'Docosahexaenoic Acids-associated-Neurologic Manifestations', 'Neurologic Manifestations-associated-Docosahexaenoic Acids', 'Stroke-down-regulate-Brain Ischemia', 'Stroke-down-regulate-Infarction', 'Hypertension-developed-Hemangioma, Cavernous, Central Nervous System', 'Hypertension-act-Infarction', 'Hypertension-determine-Disease', 'Hypertension-determine-Hemangioma, Cavernous, Central Nervous System', 'Cholesterol-considered-Malnutrition', 'Disease-developed-Hemangioma, Cavernous, Central Nervous System', 'Hypertension-developed-Glucose', 'Hypertension-determine-Glucose', 'Infarction-reduce-Glucose', 'Cerebrovascular Disorders-reduce-Glucose', 'Alzheimer Disease-reduce-Glucose', 'Disease-developed-Glucose', 'Pulmonary Disease, Chronic Obstructive-reduce-Lung Neoplasms', 'Pulmonary Disease, Chronic Obstructive-associate-SIRT1', 'SIRT1-associate-Pulmonary Disease, Chronic Obstructive', 'Digoxin-remain-Heart Failure', 'Digoxin-use-Heart Failure', 'Digoxin-use-Atrial Fibrillation', 'Alzheimer Disease-detected-Headache Disorders, Secondary', 'MAPT-detected-Headache Disorders, Secondary', 'Glucose-including-Diabetes Mellitus', 'Kidney Diseases-followed-CD79A', 'CD79A-followed-Kidney Diseases', 'Neoplasms-consist-ESR1', 'Dementia-encephalopathy with-SERPINI1', 'Brain Diseases-be with-SERPINI1', 'Epilepsy-monitored-Drug-Related Side Effects and Adverse Reactions', 'ALB-cause-Drug-Related Side Effects and Adverse Reactions', 'CST3-be higher in-Calcinosis', 'CST3-be higher compare-Heart Diseases', 'Polysaccharides-risk of-Pneumococcal Infections', 'Valproic Acid-approved-Migraine Disorders', 'CD79A-be related to-Death', 'CD79A-related-Pneumonia', 'CD79A-related-Cardiovascular Diseases', 'Fructose-increase-Triglycerides', 'Amyloidosis-include-Inflammation', 'Ghrelin-promote-Gastroparesis', 'Lipopolysaccharides-include-Inflammation', 'Ghrelin-promote-Neoplasms', 'rs1801133-associated-Neoplasms', 'Neoplasms-associated-rs1801133', 'Anemia-be due-Renal Insufficiency', 'Diabetes Mellitus-recommended-Glucose', 'Cardiovascular Diseases-recommended-Glucose', 'Hypoglycemia-accentuated-Hyperglycemia', 'Glucose-enhance-Hypoglycemia', 'Glucose-accentuated-Hyperglycemia', 'Immunologic Deficiency Syndromes-find-Osteoarthritis', 'Immunologic Deficiency Syndromes-find-Mitochondrial Diseases', 'Immunologic Deficiency Syndromes-find-TRAP1', 'Diabetes Mellitus-result-Drug-Related Side Effects and Adverse Reactions', 'INS-result-Diabetes Mellitus', 'Alzheimer Disease-linked-Parkinson Disease', 'Alzheimer Disease-linked-Lewy Body Disease', 'KL-suggest-Neoplasms', 'KL-identify-Breast Neoplasms', 'Hemorrhage-of odds be-Stroke', 'Metabolic Syndrome-main features of be-Obesity, Abdominal', 'Infections-investigated-IL2RG', 'Leukotrienes-seen-Pulmonary Disease, Chronic Obstructive', 'Congenital Abnormalities-be in-WRN', 'PRKAA2-lead-Skin Neoplasms', 'Diabetes Mellitus-compare-Cataract', 'Hyperplasia-evolve-Carcinoma in Situ', 'Carcinoma in Situ-evolve-Neoplasm Invasiveness', 'KRT14-evolve-Hyperplasia', 'KRT14-evolve-Carcinoma in Situ', 'KRT14-evolve-Neoplasm Invasiveness', 'SIRT1-involved-Nerve Degeneration', 'rs2069948-associated-PROCR', 'PROCR-associated-rs2069948', 'PROCR-associated-Stroke', 'Stroke-associated-PROCR', 'PROCR-associated-Death', 'Death-associated-PROCR', 'rs2069948-associated-Stroke', 'Stroke-associated-rs2069948', 'rs2069948-associated-Death', 'Death-associated-rs2069948', 'INS-involved-Neoplasms', 'INS-involved-Breast Neoplasms', 'Asthma-include-Chronic Disease', 'Angina Pectoris-include-Chronic Disease', 'Obesity-include-Chronic Disease', 'Pulmonary Disease, Chronic Obstructive-associated-Infections', 'Infections-associated-Pulmonary Disease, Chronic Obstructive', 'INS-associated-Infections', 'Infections-associated-INS', 'Cholesterol-include-Chronic Disease', 'Cholesterol-associated-Death, Sudden', 'Death, Sudden-associated-Cholesterol', 'Cholesterol-associated-Peripheral Arterial Disease', 'Peripheral Arterial Disease-associated-Cholesterol', 'Hypoxia-modify-Renal Insufficiency, Chronic', 'Hypoxia-evoke-EPO', 'APOE-expressed-Alzheimer Disease', 'APOE-common form of-Dementia', 'APOE-expressed-Dementia', 'Mitochondrial Diseases-play-INS', 'Insulin Glargine-associated-INS', 'INS-associated-Insulin Glargine', 'Insulin Glargine-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-Insulin Glargine', 'Memory Disorders-be feasible target for-Alzheimer Disease', 'APOE-identified-Alzheimer Disease', 'Sucralfate-prevent-Gastrointestinal Diseases', 'Sucralfate-prevent-Gastritis', 'Sucralfate-prevent-Peptic Ulcer', 'Sucralfate-prevent-Ulcer', 'Hernia, Ventral-differentiated-Neuroblastoma', 'Sucralfate-prevent-Dyspepsia', 'PINK1-differentiated-Hernia, Ventral', 'PINK1-demonstrate-Mitochondrial Diseases', 'Renal Insufficiency-present-ACE', 'Neoplasms-compare-Inflammation', 'Neoplasms-of effects be-CRP', 'Neoplasms-compare-CRP', 'Acute Kidney Injury-include-Atherosclerosis', 'Kidney Diseases-use in-Heart Failure', 'Kidney Diseases-use in-Atherosclerosis', 'Acute Kidney Injury-include-ACE', 'Diabetes Mellitus, Type 1-occur-Hyperglycemia', 'Diabetes Mellitus-preceded-Hyperglycemia', 'Diabetes Mellitus-occur-Hyperglycemia', 'PARP1-lead-Death', 'Diabetes Mellitus-account-Hyperglycemia', 'Diabetes Mellitus, Type 2-occur-Hyperglycemia', 'Osteoarthritis-reveal-CYP19A1', 'CYP19A1-reveal-Fractures, Bone', 'Cholesterol-cause-Death', 'Atherosclerosis-correlated-Diabetes Mellitus', 'Neurodegenerative Diseases-considered-Metabolic Syndrome', 'Parkinson Disease-considered-Metabolic Syndrome', 'Metabolic Syndrome-activated-INS', 'Heparin-exacerbate-Blood Coagulation Disorders', 'Heparin-exacerbate-Thrombocytopenia', 'Heparin-exacerbate-Liver Failure, Acute', 'MMP1-increase in-Xeroderma Pigmentosum', 'MMP1-found-Xeroderma Pigmentosum', 'MMP1-exacerbated-Carcinogenesis', 'Bone Diseases, Metabolic-associated-Osteoarthritis', 'Osteoarthritis-associated-Bone Diseases, Metabolic', 'Hyperoxia-include-Neurodegenerative Diseases', 'Bone Cysts-associated-Osteoarthritis', 'Osteoarthritis-associated-Bone Cysts', 'APOD-protect-Neurodegenerative Diseases', 'APOD-be long lived against-Hyperoxia', 'APOD-protect-Hyperoxia', 'Bone Diseases, Metabolic-play-KL', 'Bone Cysts-play-KL', 'KL-associated-Osteoarthritis', 'Osteoarthritis-associated-KL', 'APOD-increases in-Nervous System Diseases', 'APOD-increases in-Spinal Cord Injuries', 'Hypogonadism-be with-Diabetes Mellitus', 'Sugars-involve-Diabetes Mellitus', 'Sugars-involve-Atherosclerosis', 'Sugars-involve-Autoimmune Diseases', 'Dwarfism, Pituitary-cause-Bone Diseases, Metabolic', 'Dwarfism, Pituitary-cause bone turnover osteoporosis with-Fractures, Bone', 'Bone Diseases, Metabolic-cause-Fractures, Bone', 'GGH-cause-Bone Diseases, Metabolic', 'GGH-cause bone turnover osteoporosis with-Fractures, Bone', 'Liver Neoplasms-encode-SOD1', 'Dyskinesia, Drug-Induced-develop-Multiple Myeloma', 'COMT-tend-Dyskinesia, Drug-Induced', 'COMT-develop-Dyskinesia, Drug-Induced', 'COMT-tend-Multiple Myeloma', 'Alzheimer Disease-differentiate-Dementia, Vascular', 'Alzheimer Disease-investigate-Inflammation', 'Alzheimer Disease-assess-Memory Disorders', 'MME-assess-Memory Disorders', 'Muscular Dystrophies-characterize by-Muscular Diseases', 'Muscular Dystrophies-caused-PABPN1', 'Malignant Hyperthermia-display-Contracture', 'Malignant Hyperthermia-display-Rhabdomyolysis', 'Malignant Hyperthermia-display-Death', 'rs118192162-display-Contracture', 'rs118192162-display-Rhabdomyolysis', 'rs118192162-display-Death', 'Spherocytosis, Hereditary-detected-Sotos Syndrome', 'Spherocytosis, Hereditary-detected-PRDX2', 'PRDX2-detected-Sotos Syndrome', 'Tangier Disease-characterized-Cholesterol', 'Immunologic Deficiency Syndromes-characterized-Cholesterol', 'Congenital Hyperinsulinism-increased-Seizures', 'INS-measured-Congenital Hyperinsulinism', 'INS-use-Congenital Hyperinsulinism', 'INS-increased-Seizures', 'Diabetes Mellitus-correlate-Erectile Dysfunction', 'Anemia-correlate-Erectile Dysfunction', 'Cholesterol-correlate-Erectile Dysfunction', 'Diabetes Mellitus-used-Hypogonadism', 'Diabetes Mellitus-correlate-Hypogonadism', 'Anemia-used-Hypogonadism', 'Anemia-correlate-Hypogonadism', 'Cholesterol-used-Hypogonadism', 'Cholesterol-correlate-Hypogonadism', 'Werner Syndrome-identified-WRN', 'WRN-identified-Werner Syndrome', 'Genetic Diseases, Inborn-identified-WRN', 'KL-aspects of-Hyperphosphatemia', 'KL-mimic-Hyperphosphatemia', 'Carcinogenesis-participate-Neoplasms', 'WRN-participate in-Carcinogenesis', 'WRN-expressed-Neoplasms', 'Aneurysm-elevate-BACE1', 'MC1R-be major contributor to-Pigmentation Disorders', 'Diabetes Mellitus-associated-Acute Kidney Injury', 'Acute Kidney Injury-associated-Diabetes Mellitus', 'CRP-associated-Acute Kidney Injury', 'Acute Kidney Injury-associated-CRP', 'KL-associated-Carcinoma, Ovarian Epithelial', 'Carcinoma, Ovarian Epithelial-associated-KL', 'KL-associated-Ovarian Neoplasms', 'Ovarian Neoplasms-associated-KL', 'Inflammation-recognized-Myocardial Infarction', 'Inflammation-recognized-Stroke', 'Inflammation-recognized-Diabetes Mellitus', 'Inflammation-recognized-Metabolic Syndrome', 'Inflammation-recognized-Death', 'Inflammation-recognized-CRP', 'ADIPOQ-be as-Ischemia', 'ADIPOQ-compare-Ischemia', 'Dementia-be with-Parkinson Disease, Secondary', 'CLU-upregulated-Diabetes Mellitus, Type 2', 'CLU-upregulated-Alzheimer Disease', 'CLU-upregulated-Neoplasms', 'Tooth Loss-lead-Cardiovascular Diseases', 'Tooth Loss-lead-Stroke', 'Cholesterol-related-Cardiovascular Diseases', 'Cholesterol-related-Stroke', 'Cholesterol-related-Digestive System Neoplasms', 'C4B-found-Myocardial Infarction', 'C4B-found-Stroke', 'Alzheimer Disease-display-MAPT', 'MAPT-precede-Nerve Degeneration', 'INS-associated-Muscular Diseases', 'Muscular Diseases-associated-INS', 'Atrophy-associated-Inflammation', 'Inflammation-associated-Atrophy', 'Cachexia-associated-Inflammation', 'Inflammation-associated-Cachexia', 'TNF-discussed-Necrosis', 'TNF-discussed-Muscular Dystrophy, Duchenne', 'TNF-discussed-Atrophy', 'TNF-discussed-Cachexia', 'TNF-discussed-Inflammation', 'Multiple Myeloma-trigger-Drug-Related Side Effects and Adverse Reactions', 'Neoplasms-caused-WRN', 'Multiple Myeloma-trigger-KLRK1', 'Prostatic Neoplasms-associated-CXCL5', 'CXCL5-associated-Prostatic Neoplasms', 'CXCL5-associated-Prostatic Hyperplasia', 'Prostatic Hyperplasia-associated-CXCL5', 'CXCL5-associated-Prostatitis', 'Prostatitis-associated-CXCL5', 'CXCL5-associated-Prostatic Diseases', 'Prostatic Diseases-associated-CXCL5', 'Lung Diseases-associated-Hypertension', 'Hypertension-associated-Lung Diseases', 'Lung Diseases-associated-CD4', 'CD4-associated-Lung Diseases', 'Cachexia-proposed-Heart Failure', 'Cachexia-proposed-Neoplasms', 'Heart Failure-proposed-Hypothalamic Diseases', 'Neoplasms-proposed-Hypothalamic Diseases', 'Heart Failure-proposed-LEP', 'Neoplasms-proposed-LEP', 'INS-lead-Glucose Intolerance', 'Neoplasms-correlated-Prostatic Neoplasms, Castration-Resistant', 'Hepatitis C-exert-Neoplasms', 'EIF2AK2-exert-Neoplasms', 'Alzheimer Disease-result-PPARG', 'PPARG-result-Inflammation', 'Cholesterol-be strongest predictor of-Death', 'Cholesterol-related-Ischemia', 'Cholesterol-be related to-Hemorrhage', 'Cholesterol-be related to-Stroke', 'Cholesterol-be related to-Death', 'Werner Syndrome-result-WRN', 'Genetic Diseases, Inborn-result-WRN', 'Docosahexaenoic Acids-use-Brain Diseases', 'Docosahexaenoic Acids-use-Alzheimer Disease', 'Docosahexaenoic Acids-use-Parkinson Disease', 'CAT-be higher than-Hypertension', 'CAT-be higher than-Ischemia', 'Ischemia-result-Mastocytosis, Systemic', 'Ischemia-result-ACHE', 'Docosahexaenoic Acids-beneficial effect against-Alzheimer Disease', 'Docosahexaenoic Acids-exert-Alzheimer Disease', 'Diabetes Mellitus-extend-Hyperglycemia', 'Hypothalamic Neoplasms-contribute-Diabetes Mellitus', 'INSR-contribute-Diabetes Mellitus', 'Obesity-associated-Weight Gain', 'Weight Gain-associated-Obesity', 'Diabetes Mellitus-associated-Weight Gain', 'Weight Gain-associated-Diabetes Mellitus', 'Obesity-lowering-Glucose', 'Diabetes Mellitus-lowering-Glucose', 'Glucose-associated-Weight Gain', 'Weight Gain-associated-Glucose', 'GGH-evaluated-Osteogenesis Imperfecta', 'Glucose Intolerance-minimise-Weight Gain', 'Hyperlipidemias-include-Diabetes Mellitus', 'Diabetes Mellitus, Type 2-characterized-Hyperglycemia', 'Hyperglycemia-characterized-INS', 'Heparin-occur-Hemorrhage', 'Heparin-occur-Intracranial Hemorrhages', 'CP-increase in-Neoplasms', 'CP-increase-Prostatic Neoplasms', 'CP-increase-Neoplasms', 'Hypertension-influenced-Cyclosporine', 'Fanconi Anemia-include-Breast Neoplasms', 'Shy-Drager Syndrome-include-Breast Neoplasms', 'Fanconi Anemia-include-BRCA2', 'Shy-Drager Syndrome-include-BRCA2', 'SIRT1-regulate-Glucose Metabolism Disorders', 'Alstrom Syndrome-be multisystemic-Retinal Dystrophies', 'Alstrom Syndrome-be multisystemic-Blindness', 'SIRT1-regulate-Neurodegenerative Diseases', 'Retinal Dystrophies-lead to-Blindness', 'Retinal Dystrophies-lead-Hearing Loss, Central', 'Retinal Dystrophies-lead-Obesity', 'Retinal Dystrophies-lead-Diabetes Mellitus, Type 2', 'Retinal Dystrophies-lead-INS', 'Heart Failure-occur-Alzheimer Disease', 'Protein-Energy Malnutrition-occur-Alzheimer Disease', 'Glucose-suggest-INS', 'INS-be with-Hyperinsulinism', 'Heart Failure-suggest-INS', 'Protein-Energy Malnutrition-suggest-INS', 'Glucose-occur-Alzheimer Disease', 'Venous Thrombosis-offer-Heparin', 'Linoleic Acid-associated-Xerostomia', 'Xerostomia-associated-Linoleic Acid', 'Linoleic Acid-associated-Skin Diseases', 'Skin Diseases-associated-Linoleic Acid', 'SIRT1-sustain-Heart Arrest', 'Brain Injuries-evaluate-Brain Injuries, Traumatic', 'Atherosclerosis-improve-INS', 'Kidney Diseases-improve-INS', 'Brain Injuries-evaluate-VWF', 'Genetic Predisposition to Disease-be in-Leukemia, Myeloid, Acute', 'Muscular Dystrophies-include-Genetic Diseases, Inborn', 'Lipodystrophy-include-Genetic Diseases, Inborn', 'CFH-associate with-Inflammation', 'CFH-associate-Vision Disorders', 'Vision Disorders-associate-CFH', 'CFH-associate-Death', 'Death-associate-CFH', 'Metabolic Syndrome-associated-Colorectal Neoplasms', 'Colorectal Neoplasms-associated-Metabolic Syndrome', 'Glucose-associated-Colorectal Neoplasms', 'Colorectal Neoplasms-associated-Glucose', 'Hereditary Breast and Ovarian Cancer Syndrome-complicated-Obesity', 'Hereditary Breast and Ovarian Cancer Syndrome-complicated-INS', 'Drug-Related Side Effects and Adverse Reactions-protect-Glaucoma', 'Hypertension-clusters-Diabetes Mellitus', 'Polysaccharides-protect-Drug-Related Side Effects and Adverse Reactions', 'Insulin Resistance-augmented-Hypotension', 'Insulin Resistance-result-Hypotension', 'Polysaccharides-protect-Glaucoma', 'Hypertension-clusters-INS', 'INS-augmented-Hypotension', 'INS-result-Hypotension', 'Lung Diseases-associated-H19', 'H19-associated-Lung Diseases', 'Atherosclerosis-associated-H19', 'H19-associated-Atherosclerosis', 'Diabetes Mellitus, Type 2-result-Pancreatic Diseases', 'Diabetes Mellitus, Type 2-result-INS', 'Neurologic Manifestations-result-Drug-Related Side Effects and Adverse Reactions', 'Metabolic Syndrome-include-Gout', 'Obesity-include-Gout', 'Hypertension-include-Gout', 'Hyperlipidemias-include-Gout', 'Kidney Failure, Chronic-include-Gout', 'INS-include-Gout', 'Fatty Liver-get-Obesity', 'Triglycerides-get-Obesity', 'Infections-predict-Death', 'Infections-expansion of-CD8A', 'Infections-cause-CD8A', 'CD8A-predict-Death', 'Squamous Cell Carcinoma of Head and Neck-associated-Neoplasm Invasiveness', 'Neoplasm Invasiveness-associated-Squamous Cell Carcinoma of Head and Neck', 'Hereditary Breast and Ovarian Cancer Syndrome-associated-HIV Infections', 'HIV Infections-associated-Hereditary Breast and Ovarian Cancer Syndrome', 'Hereditary Breast and Ovarian Cancer Syndrome-associated-LMNA', 'LMNA-associated-Hereditary Breast and Ovarian Cancer Syndrome', 'Ceramides-associated-Neoplasm Invasiveness', 'Neoplasm Invasiveness-associated-Ceramides', 'TP63-characterized-Ectodermal Dysplasia', 'TP63-characterized-Abnormalities, Drug-Induced', 'Infections-respond-Cardiomyopathy, Dilated', 'Infections-respond-Hypoalbuminemia', 'Carcinoma, Merkel Cell-respond-Cardiomyopathy, Dilated', 'Carcinoma, Merkel Cell-respond-Hypoalbuminemia', 'Alzheimer Disease-challenged-Neurotoxicity Syndromes', 'Amyotrophic Lateral Sclerosis-challenged-Neurotoxicity Syndromes', 'S100A1-produce-Dementia', 'Alzheimer Disease-upregulated-SIRT1', 'SIRT1-challenged-Neurotoxicity Syndromes', 'LMNA-cause-Muscular Dystrophies', 'Heart Failure-seen-Alzheimer Disease', 'Heart Failure-deregulated-Alzheimer Disease', 'Heart Failure-deregulated-BCYRN1', 'Alzheimer Disease-deregulated-BCYRN1', 'Alzheimer Disease-linked-MAPT', 'Hyperglycemia-associated-Fatty Acids', 'Fatty Acids-associated-Hyperglycemia', 'Diabetes Mellitus-associated-Fatty Acids', 'Fatty Acids-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-Mitochondrial Diseases', 'Mitochondrial Diseases-associated-Diabetes Mellitus', 'INS-associated-Mitochondrial Diseases', 'Mitochondrial Diseases-associated-INS', 'Diabetes Mellitus-normalized-INS', 'INS-involved-Mitochondrial Diseases', 'Ghrelin-include-Cachexia', 'Kidney Diseases-be prominent risks for-Death', 'Stroke-be prominent risks for-Death', 'Parkinson Disease, Secondary-include-Shock', 'Alzheimer Disease-include-Shock', 'Drug Hypersensitivity-include-Shock', 'Obesity-be prominent risks for-Death', 'Colitis-include-Shock', 'Inflammation-include-Shock', 'Parkinson Disease, Secondary-include-Diabetes Mellitus', 'Drug Hypersensitivity-include-Diabetes Mellitus', 'Colitis-include-Diabetes Mellitus', 'Parkinson Disease, Secondary-include-Neurodegenerative Diseases', 'Cholesterol-be prominent risks for-Death', 'Polyuria-elevate-Glucose', 'Drug Hypersensitivity-include-Neurodegenerative Diseases', 'Polydipsia-elevate-Glucose', 'Colitis-include-Neurodegenerative Diseases', 'Inflammation-include-Neurodegenerative Diseases', 'Fatigue-elevate-Glucose', 'PARP1-play-Stroke', 'PARP1-play-Myocardial Infarction', 'PARP1-play-Shock', 'PARP1-play-Diabetes Mellitus', 'PARP1-play-Neurodegenerative Diseases', 'PARP1-play-Parkinson Disease, Secondary', 'PARP1-play-Alzheimer Disease', 'PARP1-play-Drug Hypersensitivity', 'PARP1-play-Colitis', 'PARP1-play-Inflammation', 'SIRT1-attenuate-Nerve Degeneration', 'Alzheimer Disease-display-Cerebrovascular Disorders', 'Cerebrovascular Disorders-derived-BACE1', 'Hyponatremia-cause-Topiramate', 'Inflammation-reflect-IL1RN', 'EPO-modulate-Neoplasms', 'Myocardial Infarction-follow-Stroke', 'EPO-favour-Neoplasms', 'EPO-express-Neoplasms', 'Cholesterol-follow-APOE', 'APOE-follow-Myocardial Infarction', 'APOE-follow-Stroke', 'APOE-follow-Diabetes Mellitus', 'Cholesterol-follow-Stroke', 'Cholesterol-follow-Diabetes Mellitus', 'Diabetes Mellitus-demonstrate-Glucose', 'Renal Insufficiency, Chronic-undergo-Movement Disorders', 'Renal Insufficiency, Chronic-undergo-Muscular Atrophy', 'Renal Insufficiency, Chronic-undergo-Osteoporosis', 'Renal Insufficiency, Chronic-undergo-Thymus Neoplasms', 'Renal Insufficiency, Chronic-undergo-Pulmonary Emphysema', 'Renal Insufficiency, Chronic-undergo-Ataxia', 'Renal Insufficiency, Chronic-undergo-Pituitary Diseases', 'Renal Insufficiency, Chronic-undergo-Hypoglycemia', 'Hypertension-investigate-Cardiovascular Diseases', 'Renal Insufficiency, Chronic-undergo-Hyperphosphatemia', 'SOD2-linked-Hypertension', 'SOD2-investigate-Cardiovascular Diseases', 'Heart Failure-be with-Death', 'Heart Failure-present-Hypernatremia', 'Heart Failure-present-Kidney Diseases', 'Death-present-Kidney Diseases', 'Pleural Effusion, Malignant-result-Lung Neoplasms', 'Pleural Effusion-result-Lung Neoplasms', 'Atorvastatin-demonstrate-Myocardial Infarction', 'Atorvastatin-demonstrate-Heart Arrest', 'KL-undergo-Calcitriol', 'Atorvastatin-demonstrate-Coronary Artery Disease', 'ENO2-result-Lung Neoplasms', 'KL-resemble-Renal Insufficiency, Chronic', 'KL-undergo-Movement Disorders', 'KL-undergo-Muscular Atrophy', 'KL-undergo-Osteoporosis', 'KL-undergo-Thymus Neoplasms', 'KL-undergo-Pulmonary Emphysema', 'KL-undergo-Ataxia', 'KL-undergo-Pituitary Diseases', 'KL-undergo-Hypoglycemia', 'KL-undergo-Hyperphosphatemia', 'Renal Insufficiency, Chronic-undergo-Calcitriol', 'Doxorubicin-result-Immunologic Deficiency Syndromes', 'Breast Neoplasms-survive-Neoplasms', 'Hyperplasia-reported-Hypothyroidism', 'Breast Neoplasms-known-WRN', 'WRN-survive-Neoplasms', 'Hyperplasia-reported-GHRH', 'EREG-result-Diabetes Mellitus', 'EREG-result-Inflammation', 'EREG-result-Neurodegenerative Diseases', 'EREG-caused-Alzheimer Disease', 'EREG-caused-Parkinson Disease', 'Ginsenosides-affect-Neurodegenerative Diseases', 'CAT-match-Cataract', 'Hypertension-compare-Obesity', 'Glucose Intolerance-compare-Obesity', 'Dyslipidemias-compare-Obesity', 'INS-compare-Obesity', 'Death-seen-Neoplasms', 'PLAU-seen-Neoplasms', 'Heart Failure-improve-Death', 'Digoxin-agent in-Heart Failure', 'Neoplasms-identified-PLAU', 'Neoplasms-find-PLAU', 'PLAU-stimulate-Carcinoma, Non-Small-Cell Lung', 'Diabetes Mellitus-shown-INS', 'Hyperinsulinism-shown-INS', 'Genetic Diseases, Inborn-result from-Ataxia Telangiectasia', 'Keratosis, Actinic-observed-Carcinogenesis', 'Carcinoma, Squamous Cell-observed-Carcinogenesis', 'rs1801133-encode-MTHFR', 'Keratosis, Actinic-observed-SIRT1', 'Carcinoma, Squamous Cell-of each be-Carcinoma, Basal Cell', 'MTHFR-involved-Osteoporosis', 'MTHFR-encode-Osteoporosis', 'Ataxia Telangiectasia-result-ATM', 'Carcinoma, Squamous Cell-observed-SIRT1', 'MTHFR-involved-Fractures, Bone', 'MTHFR-encode-Fractures, Bone', 'Genetic Diseases, Inborn-result from-ATM', 'ATM-result-Lymphoma', 'ATM-result-Immunologic Deficiency Syndromes', 'Psychomotor Agitation-attenuate-Dementia', 'Oils, Volatile-reduce-Psychomotor Agitation', 'Oils, Volatile-attenuate-Dementia', 'Atrophy-associated-Ghrelin', 'Ghrelin-associated-Atrophy', 'Infections-related-Atrophy', 'Infections-raise-Atrophy', 'Ghrelin-related-Atrophy', 'Diabetes Mellitus, Type 1-require-INS', 'INS-require-Diabetes Mellitus, Type 1', 'INS-require-Diabetes Mellitus', 'Ascorbic Acid-involved-Heart Diseases', 'Ascorbic Acid-known-Heart Diseases', 'Ascorbic Acid-involved-Retinal Degeneration', 'Ascorbic Acid-known-Retinal Degeneration', 'Ascorbic Acid-involved-Neoplasms', 'Ascorbic Acid-known-Neoplasms', 'Ascorbic Acid-provide benefits in-Neurodegenerative Diseases', 'Ascorbic Acid-known-Neurodegenerative Diseases', 'Metabolic Syndrome-refer to-Obesity, Abdominal', 'Metabolic Syndrome-refer-Obesity, Abdominal', 'Obesity-examined-Nephrolithiasis', 'rs9282858-associated-Prostatic Neoplasms', 'Prostatic Neoplasms-associated-rs9282858', 'Obesity-examined-INS', 'rs9282858-associated-Alopecia', 'Alopecia-associated-rs9282858', 'Metabolic Syndrome-refer-INS', 'INS-substantiate-Obesity', 'INS-examined-Nephrolithiasis', 'Obesity, Abdominal-linked-INS', 'Diabetes Mellitus-considered-Glucose Intolerance', 'Glucose Intolerance-compare-Glucose', 'Ghrelin-differ-Obesity', 'Valproic Acid-associated-Dementia', 'Dementia-associated-Valproic Acid', 'TFRC-become-Anemia', 'TFRC-differentiate-Anemia', 'TFRC-differentiate-Inflammation', 'Metabolism, Inborn Errors-affect-Glycogen Storage Disease Type VII', 'Metabolism, Inborn Errors-affect-Fatty Acids', 'CLU-implicated-Neoplasms', 'CLU-implicated-Aneurysm', 'CLU-implicated-Nerve Degeneration', 'CLU-correlated-Death', 'Heart Diseases-defined-Sleep Disorders, Circadian Rhythm', 'Heart Diseases-follow-Cardiomyopathy, Dilated', 'Heart Diseases-follow-Heart Failure', 'LMNA-defined-Sleep Disorders, Circadian Rhythm', 'LMNA-follow-Cardiomyopathy, Dilated', 'LMNA-follow-Heart Failure', 'Fatty Acids, Omega-3-involved-Cardiovascular Diseases', 'Fatty Acids, Omega-3-involved-Dementia', 'Fatty Acids, Omega-3-involved-Alzheimer Disease', 'Fatty Acids, Omega-3-involved-Dementia, Vascular', 'INS-be central to-Diabetes Mellitus, Type 2', 'Kidney Diseases-accompany-Diabetic Nephropathies', 'Kidney Diseases-accompany-CD79A', 'Hypogonadism-found-Chiari-Frommel Syndrome', 'Hypogonadism-found-PRL', 'PRL-found-Chiari-Frommel Syndrome', 'Bone Marrow Diseases-identify-Mycoses', 'Lymphoma, B-Cell-increase-Opportunistic Infections', 'Rituximab-identify-Mycoses', 'Tauopathies-cause-Death', 'Obesity-show-Breast Neoplasms, Male', 'Insulinoma-reveal-Glucose Intolerance', 'Metabolic Syndrome-be complex construct with-Obesity', 'Insulinoma-reveal-Hypoglycemia', 'Insulinoma-reveal-Glucose', 'Metabolic Syndrome-proposed-Cholesterol', 'Glucose-reveal-Glucose Intolerance', 'CYP1A1-related-Headache Disorders, Secondary', 'rs2606345-related-Headache Disorders, Secondary', 'Heart Failure-establish-Digoxin', 'Inflammation-be in-Narcolepsy', 'Dwarfism, Pituitary-remain-Hypopituitarism', 'Prostatic Hyperplasia-identified-KLK3', 'GSTM1-associate-Urinary Bladder Neoplasms', 'Urinary Bladder Neoplasms-associate-GSTM1', 'GSTM1-be with-Carcinogenesis', 'GSTM1-associate-Carcinogenesis', 'Carcinogenesis-associate-GSTM1', 'Anemia-use-EPO', 'Heart Failure-use-EPO', 'EPO-use-Heart Failure', 'Neurodegenerative Diseases-develop-Alzheimer Disease', 'PCNA-seen-Diabetes Mellitus', 'PCNA-compare-Cataract', 'PCNA-seen-Cataract', 'Cholesterol-associate with-Death', 'EPO-treated-Anemia, Sickle Cell', 'Aneuploidy-include-Neoplasms', 'Drug-Related Side Effects and Adverse Reactions-include-Neoplasms', 'Glucose-include-Neoplasms', 'EPO-used-Anemia, Sickle Cell', 'EPO-used-Thalassemia', 'TAT-implicated-HIV Infections', 'TAT-implicated-Neurotoxicity Syndromes', 'Anemia, Sickle Cell-receive-EPO', 'Anemia, Sickle Cell-referred-EPO', 'Hypertension, Pulmonary-given-EPO', 'Diabetes Mellitus-recognized-Diabetic Nephropathies', 'INS-recognized-Diabetic Nephropathies', 'Obesity-remain-Diabetes Mellitus', 'ACE-include-Migraine Disorders', 'ACE-include-Hypertension', 'SERPINA1-involved-Inflammation', 'SERPINA1-involved-Infections', 'Neurotoxicity Syndromes-shown-Amyotrophic Lateral Sclerosis', 'Diabetes Mellitus-remain-CRP', 'Inflammation-remain-CRP', 'Rheumatic Diseases-comprise-Polymyalgia Rheumatica', 'Rheumatic Diseases-comprise-Pain', 'Rheumatic Diseases-comprise-Hypertension', 'Polymyalgia Rheumatica-scale of-Pain', 'Polymyalgia Rheumatica-comprise-Pain', 'Polymyalgia Rheumatica-comprise-Hypertension', 'Rheumatic Diseases-comprise-CRP', 'Polymyalgia Rheumatica-comprise-CRP', 'INS-determine-Glucose', 'Chemical and Drug Induced Liver Injury-determine-Glucose', 'Chemical and Drug Induced Liver Injury-measured-Glucose', 'Nervous System Diseases-pick-Niemann-Pick Disease, Type C', 'Nervous System Diseases-pick-Alzheimer Disease', 'Inflammation-play role in-Atherosclerosis', 'Inflammation-play-CRP', 'Cholesterol-pick-Niemann-Pick Disease, Type C', 'Cholesterol-pick-Alzheimer Disease', 'Niemann-Pick Disease, Type C-characterized-Nerve Degeneration', 'Niemann-Pick Disease, Type C-characterized-Cholesterol', 'Neurodegenerative Diseases-characterized-Cholesterol', 'Atherosclerosis-associated-Myocardial Infarction', 'Myocardial Infarction-associated-Atherosclerosis', 'Sleep Wake Disorders-inhibit-Adrenocortical Carcinoma', 'Sleep Wake Disorders-exert-CRH', 'CRP-play-Atherosclerosis', 'CRP-associated-Myocardial Infarction', 'Myocardial Infarction-associated-CRP', 'Adrenocortical Carcinoma-exert-CRH', 'Death-estimate-Hypertension', 'Death-estimate-Diabetes Mellitus', 'Death-estimate-Stroke', 'MAP3K5-prevent-Thrombosis', 'Death-estimate-Angina Pectoris', 'MAP3K5-prevent-Diabetes Mellitus', 'Death-estimate-Myocardial Infarction', 'Cholesterol-experience-Cardiovascular Diseases', 'Cholesterol-reduce-Cardiovascular Diseases', 'Cholesterol-reduce-Coronary Artery Disease', 'Neoplasms-lead-Drug Hypersensitivity', 'WRN-lead-Drug Hypersensitivity', 'WRN-be in-Colorectal Neoplasms', 'WRN-be in-Neoplasms', 'Diabetes Mellitus-associated-Vascular Calcification', 'Vascular Calcification-associated-Diabetes Mellitus', 'Lipid Peroxides-associated-Vascular Calcification', 'Vascular Calcification-associated-Lipid Peroxides', 'INS-reduce-Metabolic Syndrome', 'INS-attenuate-Diabetes Mellitus, Type 2', 'INS-attenuate-Cardiovascular Diseases', 'Cardiovascular Diseases-related-Sexual Dysfunction, Physiological', 'Diabetes Mellitus-include-Cerebrovascular Disorders', 'Atrial Fibrillation-include-Cerebrovascular Disorders', 'Hypertension-include-Cerebrovascular Disorders', 'Diabetes Mellitus-include-Dementia, Vascular', 'Atrial Fibrillation-include-Dementia, Vascular', 'Hypertension-include-Dementia, Vascular', 'Atherosclerosis-include-Dementia, Vascular', 'APOE-include-Cerebrovascular Disorders', 'APOE-include-Dementia, Vascular', 'Cholesterol-include-Cerebrovascular Disorders', 'Cholesterol-include-Dementia, Vascular', 'Amyloidosis-remain-Amyloid Neuropathies, Familial', 'TTR-remain-Amyloid Neuropathies, Familial', 'Immunologic Deficiency Syndromes-cause-Friedreich Ataxia', 'Pain-result-Hypertension', 'Pain-result-Heart Failure', 'Pain-result-Acute Kidney Injury', 'Pain-result-Nephrotic Syndrome', 'Pain-result-Prostaglandins', 'Prostaglandins-result-Hypertension', 'Prostaglandins-result-Heart Failure', 'ZMPSTE24-cause-Death', 'Prostaglandins-result-Acute Kidney Injury', 'Prostaglandins-result-Nephrotic Syndrome', 'ACE-provide-Death', 'ACE-reduce-Heart Failure', 'Neurodegenerative Diseases-understand-Death', 'Neurodegenerative Diseases-base-ALB', 'ALB-base-Death', 'ALB-understand-Death', 'Neurodegenerative Diseases-base-Cholesterol', 'Cholesterol-base-Death', 'Cholesterol-understand-Death', 'Sleep Initiation and Maintenance Disorders-thought-MAPT', 'Hypotension-assumed-Hypertension', 'Hypotension-act-Hypertension', 'ADM-assumed-Hypertension', 'ADM-act-Hypertension', 'LRRK2-associated-Dementia', 'Dementia-associated-LRRK2', 'ACE-reduce-Cardiovascular Diseases', 'KLK3-used-Neoplasms', 'Kidney Diseases-include-Gout', 'Kidney Diseases-define-Gout', 'Kidney Diseases, Cystic-include-Kidney Diseases', 'Kidney Diseases, Cystic-include-Gout', 'UMOD-include-Kidney Diseases', 'UMOD-include-Gout', 'UMOD-result-Gout', 'UMOD-result-Kidney Diseases, Cystic', 'UMOD-be in-Gout', 'TP53-be in-Neoplasms', 'Insulinoma-improve-Hypoglycemia', 'Insulinoma-improve-Hyperinsulinism', 'Octreotide-prevent-Hypoglycemia', 'Octreotide-prevent-Insulinoma', 'Octreotide-improve-Hypoglycemia', 'Octreotide-improve-Hyperinsulinism', 'Hyaluronic Acid-include-Cardiac Output, Low', 'Neoplasms-be in-Obesity', 'Neoplasms-be in-Myocardial Infarction', 'SIRT7-localize-Leukemia, Myeloid, Acute', 'SIRT7-localize-Lymphoma', 'Inflammation-occur-Diabetes Mellitus, Type 2', 'Metabolic Syndrome-consist of-Obesity', 'Inflammation-occur-Atherosclerosis', 'Metabolic Syndrome-consist-Dyslipidemias', 'Metabolic Syndrome-consist-Cardiovascular Diseases', 'HTT-provide-Drug-Related Side Effects and Adverse Reactions', 'Hypertension-lead to-Cardiovascular Diseases', 'Metabolic Syndrome-consist-INS', 'Cardiomyopathies-limit-Infliximab', 'Heart Failure-limit-Infliximab', 'PTH-remain-Muscular Dystrophy, Duchenne', 'Cholesterol-induce-Atherosclerosis', 'Cholesterol-result-Atherosclerosis', 'Alzheimer Disease-suffer-Neurodegenerative Diseases', 'PIN1-patterns of-Alzheimer Disease', 'PIN1-ameliorate-Alzheimer Disease', 'PIN1-suffer-Neurodegenerative Diseases', 'Diabetes Mellitus-improve-Death', 'INS-longevity of-Diabetes Mellitus', 'Death-major cause of be-INS', 'Neurodegenerative Diseases-examine-CLU', 'Caliciviridae Infections-be in-Cardiovascular Diseases', 'Caliciviridae Infections-typified-CRP', 'CRP-remain-Diabetes Mellitus', 'Lipoid Proteinosis of Urbach and Wiethe-show-Skin Diseases', 'Doxorubicin-explored-Lymphoma', 'Doxorubicin-explored-Hematologic Diseases', 'Osteoarthritis-induced-Carcinogenesis', 'Fractures, Bone-induced-Carcinogenesis', 'Metabolic Syndrome-increased-Hypertension', 'Metabolic Syndrome-increased-Cholesterol', 'Lymphoproliferative Disorders-mimic-Leukemia, Lymphocytic, Chronic, B-Cell', 'TCL1A-develop-Lymphoproliferative Disorders', 'Leukemia, Lymphocytic, Chronic, B-Cell-implicate-TCL1A', 'TCL1A-overexpressed-Neoplasms', 'TCL1A-occur-Leukemia, Lymphocytic, Chronic, B-Cell', 'Leukemia, Prolymphocytic, T-Cell-occur-TCL1A', 'Neoplasms-occur-TCL1A', 'Diabetes Mellitus-associated-Musculoskeletal Pain', 'Musculoskeletal Pain-associated-Diabetes Mellitus', 'Erectile Dysfunction-result-ACE', 'Atherosclerosis-result-ACE', 'Glutathione-occur-Cataract', 'Glutathione-occur-Diabetes Mellitus', 'Weight Loss-prevent-Diabetes Mellitus, Type 2', 'INS-prevent-Diabetes Mellitus, Type 2', 'Glucose-prevent-Diabetes Mellitus, Type 2', 'Leukemia, Myeloid, Acute-increase-Drug-Related Side Effects and Adverse Reactions', 'Leukemia, Myeloid, Acute-suffer-Death', 'Muscular Diseases-lead-Sarcopenia', 'INS-involved-Muscular Diseases', 'INS-lead to-Sarcopenia', 'Cyclosporine-suffer-Leukemia, Myeloid, Acute', 'Inflammation-generate-Infections', 'Inflammation-exhibit-Prostaglandins', 'Pneumonia, Pneumocystis-be in-Acquired Immunodeficiency Syndrome', 'Trimethoprim, Sulfamethoxazole Drug Combination-used-Pneumonia, Pneumocystis', 'Trimethoprim, Sulfamethoxazole Drug Combination-used-Acquired Immunodeficiency Syndrome', 'Acquired Immunodeficiency Syndrome-admitted-Meningitis', 'Acquired Immunodeficiency Syndrome-use-Trimethoprim, Sulfamethoxazole Drug Combination', 'Meningitis-use-Trimethoprim, Sulfamethoxazole Drug Combination', 'Stroke-tolerated-Arthritis, Rheumatoid', 'Brain Injuries, Traumatic-tolerated-Arthritis, Rheumatoid', 'Ascorbic Acid-reduce-Pneumonia', 'Ascorbic Acid-reduce-Malaria', 'Ascorbic Acid-decline-Infections', 'Fructose-implicated-Diarrhea', 'Fructose-implicated-Inflammatory Bowel Diseases', 'Neurodegenerative Diseases-contain-MAPT', 'Inflammation-seem-Metabolic Syndrome', 'CRP-seem-Metabolic Syndrome', 'Parkinson Disease-decreased-Supranuclear Palsy, Progressive', 'Alzheimer Disease-decreased-Supranuclear Palsy, Progressive', 'Parkinson Disease-decreased-NR4A2', 'Alzheimer Disease-decreased-NR4A2', 'Stomach Neoplasms-be with-Infections', 'Stomach Neoplasms-study-Infections', 'NR4A2-decreased-Supranuclear Palsy, Progressive', 'Ulcer-study-Infections', 'Infections-study-Ulcer', 'Infections-study-S100A8', 'Lipodystrophy, Familial Partial-cause-Sertoli Cell-Only Syndrome', 'Lipodystrophy-cause-Sertoli Cell-Only Syndrome', 'Pneumococcal Infections-prevent-Death', 'Hypertrophy-cause-Sertoli Cell-Only Syndrome', 'Pneumococcal Infections-caused-Pneumonia', 'Death-caused-Pneumonia', 'Sertoli Cell-Only Syndrome-cause-Diabetes Mellitus', 'Polysaccharides-prevent-Death', 'Polysaccharides-caused-Pneumonia', 'INS-cause-Sertoli Cell-Only Syndrome', 'Glucose-be higher as-Diabetes Mellitus', 'rs11739136-highlight-Myocardial Infarction', 'rs11739136-highlight-Stroke', 'Death-attributed-Lung Diseases', 'Aging, Premature-associated-LMNA', 'LMNA-associated-Aging, Premature', 'Death-attributed-Neoplasms', 'Lung Diseases-associated-CST3', 'CST3-associated-Lung Diseases', 'Infections-associated-CST3', 'CST3-associated-Infections', 'Neoplasms-associated-CST3', 'CST3-associated-Neoplasms', 'Dementia-accumulate-Alzheimer Disease', 'Dementia-accumulate-Cerebral Amyloid Angiopathy', 'Alzheimer Disease-accumulate-Cerebral Amyloid Angiopathy', 'Dementia-accumulate-MAPT', 'Alzheimer Disease-accumulate-MAPT', 'Lipodystrophy-comprise-Heart Diseases', 'Dyslipidemias-characterized-Cholesterol', 'Lipodystrophy-present-INS', 'Heart Diseases-comprise-Nervous System Diseases', 'LMNA-comprise-Heart Diseases', 'LMNA-comprise-Nervous System Diseases', 'Lipodystrophy-lead-Diabetes Mellitus', 'Glucose-be with-Diabetes Mellitus', 'Lipodystrophy-characterized-INS', 'CYP2C19-reported-Liver Diseases', 'Hyperinsulinism-characterized-Diabetes Mellitus', 'CYP2C19-reported-Neoplasms', 'INS-characterized-Diabetes Mellitus', 'CLU-play-Alzheimer Disease', 'CLU-play-Shock', 'SIRT2-of absence be-Neoplasms', 'Hypothalamic Neoplasms-regulate-Chemical and Drug Induced Liver Injury', 'Hypothalamic Neoplasms-regulate-Hypoglycemia', 'INS-regulate food intake In-Hypothalamic Neoplasms', 'INS-regulate-Chemical and Drug Induced Liver Injury', 'EPO-be effective modalities of-Anemia', 'EPO-be effective modalities of-Primary Myelofibrosis', 'Triglycerides-risk of-Coronary Artery Disease', 'Triglycerides-quadrup-Coronary Artery Disease', 'Triglycerides-risk of-Death', 'Triglycerides-quadrup-Death', 'APOE-modulate-Cholesterol', 'APOE-modulate-Death', 'Diabetes Mellitus, Type 2-associated-Hypertension', 'Hypertension-associated-Diabetes Mellitus, Type 2', 'APOE-modulate-Ischemia', 'APOE-modulate-Seizures', 'APOE-modulate-Brain Injuries', 'Glutathione-associated-Obesity', 'Obesity-associated-Glutathione', 'Glutathione-associated-Hypertension', 'Hypertension-associated-Glutathione', 'Diabetes Mellitus-primary effect of be-Hypoglycemia', 'Diabetes Mellitus-primary effect of be-INS', 'Infections-demonstrate-CD4', 'Aging, Premature-result from-LMNA', 'Hypertension-associated-Retinal Diseases', 'Retinal Diseases-associated-Hypertension', 'Glucose-associated-Retinal Diseases', 'Retinal Diseases-associated-Glucose', 'Death-counter-Carcinogenesis', 'CEMIP-play-Death', 'CEMIP-counter-Carcinogenesis', 'Alzheimer Disease-attenuate-APOE', 'Giant Cell Arteritis-be with-Ischemia', 'Giant Cell Arteritis-compare-Ischemia', 'VEGFA-be frequent compare-Giant Cell Arteritis', 'VEGFA-be frequent among-Giant Cell Arteritis', 'VEGFA-be frequent compare-Ischemia', 'rs2010963-be frequent compare-Giant Cell Arteritis', 'rs2010963-be frequent among-Giant Cell Arteritis', 'WRN-manifest-Aging, Premature', 'rs2010963-be frequent compare-Ischemia', 'Severe Combined Immunodeficiency-result-Metabolic Diseases', 'ADA-result-Metabolic Diseases', 'ADA-characterized-Metabolic Diseases', 'Diabetes Mellitus-include-Sarcopenia', 'Dyslipidemias-include-Sarcopenia', 'Hypertension-include-Sarcopenia', 'Hyperinsulinism-recognised-Polycystic Ovary Syndrome', 'Hypertension-identified-Diabetes Mellitus', 'Obesity-identified-Diabetes Mellitus', 'Hypertension-identified-INS', 'Obesity-identified-INS', 'Flushing-caused-Arteriosclerosis', 'Flushing-caused-Angina Pectoris', 'Cholesterol-flush-Flushing', 'PREP-associated-Neuroblastoma', 'Neuroblastoma-associated-PREP', 'Cholesterol-caused-Arteriosclerosis', 'PREP-associated-Glioma', 'Glioma-associated-PREP', 'Cholesterol-caused-Angina Pectoris', 'CRP-assess-Metabolic Syndrome', 'Inflammation-assess-Coronary Artery Disease', 'Inflammation-assess-Cholesterol', 'Neurotoxicity Syndromes-preferred-Cilastatin, Imipenem Drug Combination', 'Cilastatin, Imipenem Drug Combination-preferred-Infections', 'Dwarfism, Pituitary-associated-Hypopituitarism', 'Hypopituitarism-associated-Dwarfism, Pituitary', 'Neoplasms-rendered-Neurologic Manifestations', 'TP53-rendered-Neurologic Manifestations', 'TP53-rendered-Neoplasms', 'Death-identify-Acidosis', 'Death-identify-SLC17A5', 'Leukemia-used-Drug-Related Side Effects and Adverse Reactions', 'GH1-associated-Edema', 'Edema-associated-GH1', 'GH1-associated-Arthralgia', 'Arthralgia-associated-GH1', 'GH1-associated-Carpal Tunnel Syndrome', 'Carpal Tunnel Syndrome-associated-GH1', 'Anthracyclines-used-Leukemia', 'Anthracyclines-used-Neoplasms', 'CRH-observed-Alzheimer Disease', 'CRH-compare-Alzheimer Disease', 'Hodgkin Disease-include-Lymphoma', 'MCM3AP-associated-Lymphoma', 'Lymphoma-associated-MCM3AP', 'MCM3AP-associated-Hodgkin Disease', 'Hodgkin Disease-associated-MCM3AP', 'AGER-involved-Neurodegenerative Diseases', 'AGER-involved-Melanoma', 'GFAP-associated-Alzheimer Disease', 'Alzheimer Disease-associated-GFAP', 'GFAP-associated-Plaque, Amyloid', 'Plaque, Amyloid-associated-GFAP', 'Diabetes Mellitus-defined-Hypoglycemia', 'GJA4-involved-Wounds and Injuries', 'GJA4-involved-Atherosclerosis', 'Hypoglycemia-associate-Obesity', 'Obesity-associate-Hypoglycemia', 'Hypoglycemia-remain-Obesity', 'Nerve Degeneration-follow-Stroke', 'Hypoglycemia-associate-Triglycerides', 'Triglycerides-associate-Hypoglycemia', 'Hypoglycemia-remain-Triglycerides', 'Glutathione-implicated-Parkinson Disease', 'Angina Pectoris-inhibit-AGER', 'Glutathione-implicated-Nerve Degeneration', 'Hypertension-inhibit-AGER', 'Glutathione-implicated-Stroke', 'FGF23-be responsible for-Rickets', 'AGER-implicated-Melanoma', 'Rheumatic Diseases-reduce-Stomach Diseases', 'Leukotrienes-increase-Rheumatic Diseases', 'Plaque, Atherosclerotic-reduce-Coronary Artery Disease', 'Metabolic Diseases-result-Cardiovascular Diseases', 'Hypertension-result-Cardiovascular Diseases', 'Hyperlipidemias-result-Cardiovascular Diseases', 'INS-result-Cardiovascular Diseases', 'Drug-Related Side Effects and Adverse Reactions-used-HIV Infections', 'Drug-Related Side Effects and Adverse Reactions-used-Hepatitis B, Chronic', 'Nucleosides-used-HIV Infections', 'Nucleosides-used-Hepatitis B, Chronic', 'Drug-Related Side Effects and Adverse Reactions-speculate-Neurodegenerative Diseases', 'Drug-Related Side Effects and Adverse Reactions-associated-Docosahexaenoic Acids', 'Docosahexaenoic Acids-associated-Drug-Related Side Effects and Adverse Reactions', 'Drug-Related Side Effects and Adverse Reactions-block-Docosahexaenoic Acids', 'Docosahexaenoic Acids-speculate-Neurodegenerative Diseases', 'von Willebrand Diseases-associated-Mucocutaneous Lymph Node Syndrome', 'Mucocutaneous Lymph Node Syndrome-associated-von Willebrand Diseases', 'ACE-associated-Mucocutaneous Lymph Node Syndrome', 'Mucocutaneous Lymph Node Syndrome-associated-ACE', 'APOE-allele of be-Brain Ischemia', 'Dwarfism, Pituitary-used-Obesity', 'GHRH-used-Obesity', 'TLR4-associated-Atherosclerosis', 'Atherosclerosis-associated-TLR4', 'TLR4-associated-Inflammation', 'Inflammation-associated-TLR4', 'Delirium-dispensed-Valproic Acid', 'Hypopituitarism-related-Fractures, Bone', 'GH1-related-Fractures, Bone', 'ACE-result-Heart Failure', 'Mitochondrial Diseases-contribute-Diabetes Mellitus', 'Mitochondrial Diseases-contribute-INS', 'Infections-be susceptible than-Respiratory Tract Infections', 'Infections-isolated-Respiratory Tract Infections', 'Respiratory Tract Infections-isolated-Trimethoprim, Sulfamethoxazole Drug Combination', 'Lipodystrophy-transmitted-Communicable Diseases', 'Lipodystrophy, Familial Partial-transmitted-Communicable Diseases', 'LMNA-transmitted-Communicable Diseases', 'Lipodystrophy-bear-LMNA', 'Lipodystrophy-associated-rs60864230', 'rs60864230-associated-Lipodystrophy', 'Lipodystrophy-bear-rs60864230', 'Muscular Dystrophy, Duchenne-measured-Diabetes Mellitus', 'Muscular Dystrophy, Duchenne-measured-Glucose Metabolism Disorders', 'Muscular Dystrophy, Duchenne-measured-Glucose', 'Chemical and Drug Induced Liver Injury-expected-Glutathione', 'Atherosclerosis-be in-Progeria', 'ADIPOQ-represent-Atherosclerosis', 'ADIPOQ-represent-Progeria', 'Progeria-encoded-LMNA', 'Clindamycin-be antibiotics-Diarrhea', 'Clindamycin-associated-Diarrhea', 'Diarrhea-associated-Clindamycin', 'Clindamycin-associated-Colitis', 'Colitis-associated-Clindamycin', 'Fatty Acids, Omega-3-play-Dementia', 'Fatty Acids, Omega-3-play-Alzheimer Disease', 'PKD1-predispose-Kidney Diseases, Cystic', 'PKD1-predispose-Intracranial Aneurysm', 'Hypertension-be with-Kidney Diseases', 'rs1800629-associated-Shock, Septic', 'Shock, Septic-associated-rs1800629', 'rs1800629-associated-Death', 'Death-associated-rs1800629', 'Diabetes Mellitus-postulated-INS', 'Breast Neoplasms-postulated-INS', 'Heparin-use of be-Neoplasms', 'Hypertension-alter-Cardiovascular Diseases', 'Cholesterol-alter-Cardiovascular Diseases', 'Neoplasms-include-Hypothalamic Neoplasms', 'Neoplasms-include-CYP19A1', 'Blood Loss, Surgical-remain-Surgical Wound Infection', 'CLU-regulated-Death', 'CLU-regulated-Neoplasms', 'CLU-regulated-Heredodegenerative Disorders, Nervous System', 'APOE-increase-Alzheimer Disease', 'APOE-increase-Cardiovascular Diseases', 'End Stage Liver Disease-produced-Hypertension', 'End Stage Liver Disease-produced-Sucrose', 'Bone Marrow Failure Disorders-include-Abnormalities, Multiple', 'Neoplasms-include-Abnormalities, Multiple', 'DKC1-result-Abnormalities, Multiple', 'DKC1-result-Bone Marrow Failure Disorders', 'TERC-result-Abnormalities, Multiple', 'Dyskeratosis Congenita-come-Genetic Diseases, Inborn', 'Dyskeratosis Congenita-regarded-Genetic Diseases, Inborn', 'TERC-regarded-Genetic Diseases, Inborn', 'Infections-improve-CD4', 'PAX3-be important gene such-Rhabdomyosarcoma', 'TNFSF11-involve-Calcinosis', 'PAX3-analyzed-Rhabdomyosarcoma, Embryonal', 'PAX3-analyzed-Rhabdomyosarcoma, Alveolar', 'Alzheimer Disease-expressed-Ceramides', 'Ceramides-expressed-Amyotrophic Lateral Sclerosis', 'Ceramides-increased-Neurodegenerative Diseases', 'Ceramides-increased-Alzheimer Disease', 'Ceramides-increased-Amyotrophic Lateral Sclerosis', 'Neoplasms-screened-Skin Neoplasms', 'TP53-screened-Skin Neoplasms', 'MTHFR-replaced-rs1801133', 'Hyperthyroidism-result-SHBG', 'Alzheimer Disease-result-SHBG', 'CYP19A1-associated-Bone Diseases', 'Bone Diseases-associated-CYP19A1', 'CYP19A1-associated-Bone Neoplasms', 'Bone Neoplasms-associated-CYP19A1', 'Non-alcoholic Fatty Liver Disease-observed-Metabolic Syndrome', 'Non-alcoholic Fatty Liver Disease-observed-Glucose', 'Erectile Dysfunction-involve-Corneal Endothelial Cell Loss', 'Erectile Dysfunction-caused-Fibrosis', 'Erectile Dysfunction-involve-NOS3', 'Glucose Intolerance-compare-Non-alcoholic Fatty Liver Disease', 'Obesity, Metabolically Benign-compare-Non-alcoholic Fatty Liver Disease', 'Lipofuscin-observed-Reflex, Abnormal', 'Lipofuscin-observed-Retinal Degeneration', 'Hip Fractures-offer-Venous Thromboembolism', 'Fondaparinux-offer prophylaxis As-Hip Fractures', 'Fondaparinux-offer-Venous Thromboembolism', 'Sclerosis-upregulated-Cerebral Infarction', 'Sclerosis-upregulated-Hemorrhage', 'LMNA-show-Cardiovascular Abnormalities', 'Coronary Artery Disease-be common of-Cardiovascular Diseases', 'rs57920071-show-Cardiovascular Abnormalities', 'Neuroblastoma-increase-Drug-Related Side Effects and Adverse Reactions', 'Neuroblastoma-increase sensitivity compare-Glioblastoma', 'Drug-Related Side Effects and Adverse Reactions-compare-Glioblastoma', 'Drug-Related Side Effects and Adverse Reactions-compare-Glutathione', 'Hypertriglyceridemia-related-INS', 'Hirsutism-related-INS', 'Diabetic Angiopathies-include-Atherosclerosis', 'SPP1-play-Atherosclerosis', 'SPP1-thought-Atherosclerosis', 'SPP1-play-Diabetic Angiopathies', 'SPP1-thought-Diabetic Angiopathies', 'Kidney Diseases-be in-Diabetes Mellitus', 'Diabetes Mellitus-evaluated-Retinal Diseases', 'Diabetes Mellitus-evaluated-Nervous System Diseases', 'Diabetes Mellitus-evaluated-Kidney Diseases', 'Diabetes Mellitus-evaluated-SPP1', 'SPP1-evaluated-Retinal Diseases', 'SPP1-evaluated-Nervous System Diseases', 'SPP1-increase-Diabetic Nephropathies', 'SPP1-increase-Renal Insufficiency', 'Diabetes Mellitus, Type 2-treated-ACE', 'Hypertension-treated-ACE', 'Diabetes Mellitus-receive-ACE', 'Hypertension-receive-ACE', 'INS-manifest as-Obesity', 'INS-manifest-Diabetes Mellitus', 'Lens Diseases-induce-Cataract', 'Lens Diseases-induce-Mastocytosis, Systemic', 'Diabetes Mellitus-prevent-ACE', 'Lens Diseases-induce-Diabetes Mellitus', 'Fatty Acids, Nonesterified-induce-Lens Diseases', 'Fatty Acids, Nonesterified-induce-Cataract', 'Neoplasms-infect-Infections', 'Fatty Acids, Nonesterified-induce-Mastocytosis, Systemic', 'WRN-involved-Neoplasms', 'WRN-involved-Infections', 'WRN-infect-Infections', 'Fatty Acids, Nonesterified-induce-Diabetes Mellitus', 'Polysaccharides-provide-Pneumococcal Infections', 'Nausea-associated-Neoplasms', 'Neoplasms-associated-Nausea', 'Vomiting-associated-Neoplasms', 'Neoplasms-associated-Vomiting', 'TAC1-control-Nausea', 'TAC1-associated-Neoplasms', 'Neoplasms-associated-TAC1', 'GH1-suggested-Osteoporosis', 'GH1-suggested-Obesity', 'GH1-suggested-Heart Failure', 'PPT1-result-Genetic Diseases, Inborn', 'APOE-shown-Alzheimer Disease', 'APOE-shown-Brain Injuries', 'Lipodystrophy-be with-Growth Disorders', 'Diarrhea-associated-Pancreatitis', 'Pancreatitis-associated-Diarrhea', 'Sepsis-associated-Pancreatitis', 'Pancreatitis-associated-Sepsis', 'Sepsis-associated-Neoplasms', 'Neoplasms-associated-Sepsis', 'Pancreatitis-associated-Neoplasms', 'Neoplasms-associated-Pancreatitis', 'Pancreatitis-associated-Colitis, Ulcerative', 'Colitis, Ulcerative-associated-Pancreatitis', 'Pancreatitis-associated-Cholesterol', 'Cholesterol-associated-Pancreatitis', 'TERC-underlie-Skin Diseases', 'Ceramides-measured-Squamous Cell Carcinoma of Head and Neck', 'Ceramides-measured-Head and Neck Neoplasms', 'Bone Neoplasms-be in-Osteoporosis', 'TGFA-reduce-Bone Neoplasms', 'TGFA-reduce-Osteoporosis', 'Osteoporosis-mediated-Inflammation', 'Drug Overdose-lead-Kidney Diseases', 'Heparin-lead-Drug Overdose', 'Heparin-lead-Kidney Diseases', 'MAPT-show-Alzheimer Disease', 'MAPT-determine-Alzheimer Disease', 'MAPT-detect-Alzheimer Disease', 'Hyperglycemia-treated-Ketosis', 'Hyperglycemia-monitor-Glucose', 'Ketosis-monitor-Glucose', 'Bone Neoplasms-increase-Osteoporotic Fractures', 'APOE-associated-Muscular Dystrophy, Duchenne', 'Muscular Dystrophy, Duchenne-associated-APOE', 'Fondaparinux-approved-Venous Thromboembolism', 'Fondaparinux-approved-Hip Fractures', 'ACE-be with-Heart Failure', 'GH1-reduce-Cholesterol', 'TNF-associated-Dementia', 'Dementia-associated-TNF', 'GH1-reduce-Cardiovascular Diseases', 'GH1-improve-Carpal Tunnel Syndrome', 'GH1-improve-Edema', 'GH1-improve-Arthralgia', 'GH1-improve-Gynecomastia', 'GH1-improve-Glucose Intolerance', 'GH1-reduce-Neoplasms', 'Cholesterol-reduce-Edema', 'Urinary Incontinence-include-Diabetes Mellitus', 'Urinary Incontinence-treated-Diabetes Mellitus', 'Heart Diseases-observe-Diabetes Mellitus', 'Arthritis-include-Urinary Incontinence', 'Triglycerides-observe-Diabetes Mellitus', 'Hemorrhage-occur-Heparin', 'INS-include-Urinary Incontinence', 'Diabetes Mellitus-encompass-Cerebrovascular Disorders', 'Glucose-encompass-Diabetes Mellitus', 'Diabetes Mellitus-implicate-Carcinogenesis', 'WRN-increase-Carcinogenesis', 'Neoplasms-be underlying cause of-Death', 'Neoplasms-include-Respiratory Tract Neoplasms', 'Hodgkin Disease-include-Neoplasms', 'Leukemia, Myeloid-include-Neoplasms', 'Neoplasms-include-CD4', 'PON1-confer-Coronary Artery Disease', 'Death-be related after-Coronary Artery Disease', 'Death-be related to-Coronary Artery Disease', 'PON1-confer-Death', 'PON1-associated-Death', 'Death-associated-PON1', 'PON1-associated-Coronary Artery Disease', 'Coronary Artery Disease-associated-PON1', 'Alzheimer Disease-suggest-Neurodegenerative Diseases', 'Dementia, Vascular-suggest-Neurodegenerative Diseases', 'Cholesterol-show-Alzheimer Disease', 'Cholesterol-show-Dementia, Vascular', 'Heart Failure-differ-Coronary Artery Disease', 'Glutathione-associated-Opium Dependence', 'Opium Dependence-associated-Glutathione', 'Glutathione-associated-Lung Neoplasms', 'Lung Neoplasms-associated-Glutathione', 'Diabetes Mellitus-predict-Muscular Dystrophy, Duchenne', 'Diabetes Mellitus-predict-INS', 'Diabetes Mellitus, Type 2-associated-Muscular Dystrophy, Duchenne', 'Muscular Dystrophy, Duchenne-associated-Diabetes Mellitus, Type 2', 'Neurodegenerative Diseases-increase-Obesity', 'Neurodegenerative Diseases-increase-INS', 'Venlafaxine Hydrochloride-have demonstrate-Pain', 'Venlafaxine Hydrochloride-have demonstrate-Diabetic Neuropathies', 'Valproic Acid-associated-Headache Disorders, Secondary', 'Headache Disorders, Secondary-associated-Valproic Acid', 'Valproic Acid-associated-Weight Gain', 'Weight Gain-associated-Valproic Acid', 'FXN-protect-Death', 'Neoplasms-localised-Teratoma', 'Neoplasms-affected-Teratoma', 'Neoplasms-associated-Teratoma', 'Teratoma-associated-Neoplasms', 'NES-localised-Neoplasms', 'NES-affected-Neoplasms', 'NES-associated-Neoplasms', 'Neoplasms-associated-NES', 'NES-localised-Teratoma', 'Dementia-be in-HIV Infections', 'TNFRSF11B-appear-Osteoarthritis', 'Kidney Failure, Chronic-occur-Vascular Calcification', 'Kidney Failure, Chronic-occur-Hyperglycemia', 'Kidney Failure, Chronic-occur-Hyperphosphatemia', 'Kidney Failure, Chronic-occur-Hypercholesterolemia', 'Myalgia-improve-Glucose Metabolism Disorders', 'Kidney Failure, Chronic-occur-Hypertension', 'Myalgia-improve-INS', 'Kidney Failure, Chronic-contribute-Calcinosis', 'Vascular Calcification-occur-Hyperglycemia', 'Vascular Calcification-occur-Hyperphosphatemia', 'Vascular Calcification-occur-Hypercholesterolemia', 'Vascular Calcification-occur-Hypertension', 'Vascular Calcification-contribute-Calcinosis', 'INS-be impaired in-Diabetes Mellitus, Type 2', 'Hyperglycemia-contribute-Calcinosis', 'Hyperphosphatemia-contribute-Calcinosis', 'Hypercholesterolemia-contribute-Calcinosis', 'Hypertension-contribute-Calcinosis', 'Kidney Failure, Chronic-occur-Calcitriol', 'Vascular Calcification-occur-Calcitriol', 'Calcitriol-contribute to-Calcinosis', 'INS-contribute-Mitochondrial Diseases', 'Obesity-include-Heart Diseases', 'Heart Diseases-include-Infections', 'Heart Diseases-caused-Infections', 'Obesity-caused-Infections', 'Tuberculosis-bear-Cardiovascular Diseases', 'Tuberculosis-depend-Cholesterol', 'Atherosclerosis-suggested-Heart Diseases', 'Cholesterol-depend-Cardiovascular Diseases', 'Heart Diseases-lead-Tuberculosis', 'Cholesterol-caused-Infections', 'Atherosclerosis-suggested-CRP', 'Ocular Hypertension-influence-Arteriosclerosis', 'CRP-lead-Tuberculosis', 'Cardiovascular Abnormalities-associated-Leukocytosis', 'Leukocytosis-associated-Cardiovascular Abnormalities', 'Cardiovascular Abnormalities-associated-FANCB', 'FANCB-associated-Cardiovascular Abnormalities', 'PON1-associate-Atherosclerosis', 'Atherosclerosis-associate-PON1', 'Atherosclerosis-increased-Alzheimer Disease', 'Sleep Initiation and Maintenance Disorders-constitute-HIV Infections', 'Anemia-develop-EPO', 'Dementia-experience-Psychomotor Agitation', 'Atherosclerosis-co-existence of-Osteoporosis', 'Atherosclerosis-explain-Osteoporosis', 'Valproic Acid-derive-Dementia', 'Atherosclerosis-co-existence in-Dyslipidemias', 'Atherosclerosis-explain-Dyslipidemias', 'Valproic Acid-derive-Psychomotor Agitation', 'Valproic Acid-experience-Psychomotor Agitation', 'Coronary Artery Disease-be predictive of-Heart Failure', 'Neurodegenerative Diseases-classify-Synucleinopathies', 'Parkinson Disease, Secondary-classify-Synucleinopathies', 'rs17125721-be related to-Alzheimer Disease', 'rs17125721-assessed-Parkinson Disease', 'Heart Diseases-be common clinical manifestation in-Amyloid Neuropathies, Familial', 'Heart Diseases-occur in-Amyloid Neuropathies, Familial', 'Heart Diseases-occur-Amyloid Neuropathies, Familial', 'Cholesterol-associated-Liver Diseases', 'Liver Diseases-associated-Cholesterol', 'Cholesterol-associated-Intellectual Disability', 'Intellectual Disability-associated-Cholesterol', 'Heart Diseases-be with-Heart Failure', 'Glutathione-contribute-Seizures', 'INS-implicate-Diabetes Mellitus', 'Glutathione-contribute-Alzheimer Disease', 'INS-implicate-Thrombosis', 'Glutathione-contribute-Parkinson Disease', 'INS-implicate-Cardiovascular Diseases', 'Glutathione-contribute-Liver Diseases', 'INS-represent-Triglycerides', 'INS-represent-Hypertension', 'Glutathione-contribute-Cystic Fibrosis', 'Glutathione-contribute-Anemia', 'INS-represent-Obesity', 'Glutathione-contribute-HIV Infections', 'Glutathione-contribute-Acquired Immunodeficiency Syndrome', 'Glutathione-contribute-Neoplasms', 'Glutathione-contribute-Stroke', 'Glutathione-contribute-Diabetes Mellitus', 'Lipofuscin-implicated-Atherosclerosis', 'Lipofuscin-implicated-Dementia', 'Weight Loss-prevent-Diabetes Mellitus', 'Lipofuscin-implicated-Alzheimer Disease', 'INS-identify-Weight Loss', 'Colorectal Neoplasms-examine-Neoplasms', 'Polysaccharides-used-Colorectal Neoplasms', 'Polysaccharides-examine-Neoplasms', 'LCT-identify-Lactose Intolerance', 'LCT-identify-Osteoporosis', 'INS-contribute-Hyperandrogenism', 'Polycystic Ovary Syndrome-provide-Glucose Intolerance', 'Obesity-include-Polycystic Ovary Syndrome', 'Polycystic Ovary Syndrome-provide-INS', 'INS-include-Polycystic Ovary Syndrome', 'INS-define-Polycystic Ovary Syndrome', 'Polysaccharides-have prove-Pneumococcal Infections', 'Obesity-screened-Insulin Resistance', 'Obesity-screened-Hypertension', 'Obesity-screened-Dyslipidemias', 'Obesity-screened-Glucose Intolerance', 'Polycystic Ovary Syndrome-screened-Insulin Resistance', 'Polycystic Ovary Syndrome-screened-Hypertension', 'Polycystic Ovary Syndrome-screened-Dyslipidemias', 'Polycystic Ovary Syndrome-screened-Obesity', 'Polycystic Ovary Syndrome-screened-Glucose Intolerance', 'Heart Failure-characterized-Osteoporosis', 'Heart Failure-characterized-Hip Fractures', 'Heart Failure-characterized-ALB', 'Obesity-screened-INS', 'Polycystic Ovary Syndrome-screened-INS', 'Osteoporosis-characterized-ALB', 'Hip Fractures-characterized-ALB', 'Heart Failure-characterized-Cholesterol', 'Osteoporosis-characterized-Cholesterol', 'Diabetes Mellitus-lead-Hypoglycemia', 'Diabetes Mellitus-monitor-Glucose', 'Diabetes Mellitus-impair-Glucose', 'Glucose-lead-Hypoglycemia', 'Alzheimer Disease-suggest-Muscular Atrophy', 'Death-induce-Alzheimer Disease', 'Zanamivir-used-Asthma', 'GRIA2-induce-Death', 'Zanamivir-used-Pulmonary Disease, Chronic Obstructive', 'Bronchial Spasm-occur-Respiratory Tract Diseases', 'Bronchial Spasm-occur-Zanamivir', 'Respiratory Tract Diseases-treated-Zanamivir', 'Respiratory Tract Diseases-elucidate-Bronchial Spasm', 'Tobramycin-recommended-Infections', 'Zanamivir-elucidate-Bronchial Spasm', 'Tobramycin-recommended-Cystic Fibrosis', 'Genetic Diseases, Inborn-implicated-Parkinson Disease', 'Cholesterol-increase-Drug-Related Side Effects and Adverse Reactions', 'Cholesterol-drive-Alzheimer Disease', 'Cardiac Output, Low-reduce-Headache Disorders, Secondary', 'Tramadol-fall-Cardiac Output, Low', 'Tramadol-reduce-Headache Disorders, Secondary', 'PTH-increase-Sarcopenia', 'Alzheimer Disease-associated-Psychoses, Substance-Induced', 'Psychoses, Substance-Induced-associated-Alzheimer Disease', 'PSEN1-associated-Psychoses, Substance-Induced', 'Psychoses, Substance-Induced-associated-PSEN1', 'Anemia-undergo-EPO', 'Neoplasms-undergo-EPO', 'Seizures-demonstrate-Drug Hypersensitivity', 'Seizures-demonstrate-Tramadol', 'Drug Hypersensitivity-demonstrate-Tramadol', 'Inflammation-strengthen-Alzheimer Disease', 'Inflammation-strengthen-Thioctic Acid', 'Thioctic Acid-strengthen-Alzheimer Disease', 'Abnormalities, Drug-Induced-contribute-Neoplasms', 'Abnormalities, Drug-Induced-contribute-Colorectal Neoplasms', 'Hypertension-reduce-Headache', 'Hypertension-reduce-ACE', 'Hypertension-be elevated from-Atherosclerosis', 'Cholesterol-elevated-Atherosclerosis', 'Diabetes Mellitus-result-Insulin Resistance', 'Metabolic Diseases-result-Insulin Resistance', 'ACE-associated-Headache', 'Headache-associated-ACE', 'ICOS-compare-Parasitic Diseases', 'Ventricular Dysfunction, Left-reduce-Death', 'Ventricular Dysfunction, Left-reduce-Ventricular Remodeling', 'Ventricular Dysfunction, Left-reduce-Cardiomyopathy, Hypertrophic', 'Ventricular Dysfunction, Left-reduce-Kidney Diseases', 'Ventricular Dysfunction, Left-associated-Myocardial Infarction', 'Myocardial Infarction-associated-Ventricular Dysfunction, Left', 'NR3C2-play-Ventricular Dysfunction, Left', 'NR3C2-play-Hypertension', 'NR3C2-play-Heart Failure, Diastolic', 'NR3C2-play-Heart Valve Diseases', 'NR3C2-play-Kidney Diseases', 'NR3C2-play-Diabetes Mellitus', 'Ventricular Dysfunction, Left-reduce-NR3C2', 'NR3C2-reduce-Ventricular Remodeling', 'NR3C2-reduce-Cardiomyopathy, Hypertrophic', 'NR3C2-reduce-Kidney Diseases', 'Hypoxia-detected-Mitochondrial Diseases', 'NPEPPS-detected-Mitochondrial Diseases', 'Glycosides-evaluated-Neoplasms', 'Bone Marrow Diseases-receive-Lymphoma, Non-Hodgkin', 'Cerebrovascular Disorders-include-Cerebral Amyloid Angiopathy', 'Alzheimer Disease-include-Cerebral Amyloid Angiopathy', 'Glycosides-evaluated-Breast Neoplasms', 'Graves Disease-subdivide-Graves Ophthalmopathy', 'APOE-include-Cerebral Amyloid Angiopathy', 'Prostaglandins-play-Inflammation', 'Hyponatremia-alter-AVP', 'ACE-be in-Heart Failure', 'Cerebral Amyloid Angiopathy-examine-Alzheimer Disease', 'Cerebral Amyloid Angiopathy-examine-Cerebral Hemorrhage', 'Dementia-treat-Seizures', 'Cerebral Amyloid Angiopathy-examine-APOE', 'Seizures-provide-Valproic Acid', 'Nervous System Diseases-use-Valproic Acid', 'Torsades de Pointes-cough with-ACE', 'Cough-be with-ACE', 'WRN-cause-Neoplasms', 'Fibrosis-increased-Ascites', 'Fibrosis-associated-Ascites', 'Ascites-associated-Fibrosis', 'Fibrosis-increased-Brain Diseases', 'Fibrosis-associated-Brain Diseases', 'Brain Diseases-associated-Fibrosis', 'Fibrosis-associated-Postpartum Hemorrhage', 'Postpartum Hemorrhage-associated-Fibrosis', 'Fibrosis-increased-Postpartum Hemorrhage', 'Fibrosis-increased-ALB', 'Fibrosis-associated-ALB', 'ALB-associated-Fibrosis', 'Osteosarcoma-compare-Osteoarthritis', 'INS-compare-Osteoarthritis', 'Prostaglandins-associated-Nerve Degeneration', 'Nerve Degeneration-associated-Prostaglandins', 'Prostaglandins-associated-Neurodegenerative Diseases', 'Neurodegenerative Diseases-associated-Prostaglandins', 'Neoplasms-induce-Death', 'Death-lead cause of be-Cardiovascular Diseases', 'Cardiovascular Diseases-be with-Death', 'SOD1-induce cell death in-Neoplasms', 'Death-lead cause of be-Cholesterol', 'SOD1-induce-Death', 'Cardiovascular Diseases-be with-Cholesterol', 'Death-be in-Cholesterol', 'ACE-be in-Inflammation', 'ACE-be in-Osteoarthritis', 'Neurodegenerative Diseases-correspond-Parkinson Disease', 'IL6-associated-Arthritis', 'Arthritis-associated-IL6', 'IL6-associated-Periodontal Diseases', 'Periodontal Diseases-associated-IL6', 'Death-regard-Cholesterol', 'Chemical and Drug Induced Liver Injury-degree of-Fat Necrosis', 'INS-degree of-Fat Necrosis', 'Chemical and Drug Induced Liver Injury-indexes of-INS', 'INS-include-Obesity, Abdominal', 'INS-include-Hypertension', 'INS-include-Dyslipidemias', 'INS-include-Glucose Intolerance', 'Inflammation-suggest-Fatty Acids', 'Atherosclerosis-suggest-Fatty Acids', 'CRP-underlie-Fatty Acids', 'Atherosclerosis-measure-CRP', 'Atherosclerosis-underlie-Fatty Acids', 'Hypotension-show-Acute Coronary Syndrome', 'Hypotension-reduce-Ischemia', 'Hypotension-show-Angina, Stable', 'Acute Coronary Syndrome-reduce-Ischemia', 'Ischemia-be in-Angina, Stable', 'Hypotension-show-Atorvastatin', 'Aneuploidy-show-AURKA', 'Seminoma-show-AURKA', 'Atorvastatin-reduce-Ischemia', 'Aneuploidy-associated-AURKA', 'AURKA-associated-Aneuploidy', 'Neoplasms-associated-AURKA', 'AURKA-associated-Neoplasms', 'PNPLA6-lead-Puberty, Delayed', 'Death-underused-Pneumococcal Infections', 'Death-underused-Polysaccharides', 'Kidney Diseases-exist-ALB', 'Myocardial Infarction-convincing-Heart Failure', 'Myocardial Infarction-include-Heart Failure', 'Diabetes Mellitus-convincing-Myocardial Infarction', 'Hypertension-convincing-Myocardial Infarction', 'Hypertension-be with-Heart Failure', 'Diabetes Mellitus-convincing-Heart Failure', 'Hypertension-convincing-Heart Failure', 'Myocardial Infarction-convincing-ACE', 'Myocardial Infarction-include-ACE', 'ACE-convincing-Heart Failure', 'ACE-include-Heart Failure', 'Diabetes Mellitus-convincing-ACE', 'Diabetes Mellitus-include-ACE', 'Hypertension-convincing-ACE', 'Hypertension-include-ACE', 'Glucose-reduce-Hypertension', 'Hypertension-proven-Enalapril', 'Cerebrovascular Disorders-derived-Coronary Artery Disease', 'Cholesterol-derived-Coronary Artery Disease', 'Organophosphate Poisoning-produce-Neurotoxicity Syndromes', 'Stroke-be in-Cholesterol', 'Stroke-examine-Cholesterol', 'Metabolic Syndrome-unite-Obesity', 'HFE-involved-Chronic Disease', 'Metabolic Syndrome-unite-INS', 'HFE-involved-Alzheimer Disease', 'Metabolic Syndrome-manifested-Obesity', 'HFE-involved-Coronary Artery Disease', 'Metabolic Syndrome-manifested-Dyslipidemias', 'Metabolic Syndrome-manifested-Hypertension', 'Metabolic Syndrome-increase-Coronary Artery Disease', 'Metabolic Syndrome-conceived-Coronary Artery Disease', 'Metabolic Syndrome-conceived-Diabetes Mellitus, Type 2', 'Metabolic Syndrome-increase-Diabetes Mellitus, Type 2', 'Obesity-conceived-Coronary Artery Disease', 'Obesity-conceived-Diabetes Mellitus, Type 2', 'Dyslipidemias-conceived-Coronary Artery Disease', 'Dyslipidemias-conceived-Diabetes Mellitus, Type 2', 'Hypertension-conceived-Coronary Artery Disease', 'Hypertension-conceived-Diabetes Mellitus, Type 2', 'Hypoalphalipoproteinemias-associated-Coronary Artery Disease', 'Coronary Artery Disease-associated-Hypoalphalipoproteinemias', 'Metabolic Syndrome-manifested-INS', 'INS-conceived-Coronary Artery Disease', 'INS-conceived-Diabetes Mellitus, Type 2', 'Metabolic Syndrome-represented-Obesity', 'Metabolic Syndrome-represented-INS', 'Heart Failure-caused-Ventricular Dysfunction, Left', 'AP2B1-caused-Ventricular Dysfunction, Left', 'Lymphoma-reduced-Drug-Related Side Effects and Adverse Reactions', 'Lymphoma-affected-Daunorubicin', 'Daunorubicin-reduced-Drug-Related Side Effects and Adverse Reactions', 'Femoral Neck Fractures-shown-ALB', 'Fractures, Bone-shown-ALB', 'Fractures, Bone-associated-ALB', 'ALB-associated-Fractures, Bone', 'Pancreatic Neoplasms-investigate-Adenocarcinoma', 'CCND2-investigate-Adenocarcinoma', 'KL-influence-Atherosclerosis', 'KL-assess-Coronary Artery Disease', 'KL-influence-Coronary Artery Disease', 'Obesity, Abdominal-include-Diabetes Mellitus', 'Diabetes Mellitus-reduce-Heart Failure', 'Obesity, Abdominal-include-Cardiovascular Diseases', 'Hyperglycemia-include-Cardiovascular Diseases', 'ACE-reduce-Diabetes Mellitus', 'Dyslipidemias-characterized-Hyperglycemia', 'Dyslipidemias-characterized-Hypertension', 'INS-consist-Triglycerides', 'INS-consist of-Diabetes Mellitus', 'INS-consist-Cardiovascular Diseases', 'INS-consist of-Obesity', 'INS-consist-Obesity, Abdominal', 'INS-consist-Dyslipidemias', 'INS-consist-Hyperglycemia', 'INS-consist-Hypertension', 'Triglycerides-include-Cardiovascular Diseases', 'Dyslipidemias-characterized-Triglycerides', 'Gastrointestinal Stromal Tumors-of study be-Neoplasms', 'Myocardial Infarction-found-CYBB', 'MAPT-measure-Alzheimer Disease', 'MAPT-measure-Dementia, Vascular', 'MAPT-achieve values for-Alzheimer Disease', 'Breast Neoplasms-lack-TP53', 'Neoplasms-lack-TP53', 'Hypertension-of diagnoses be-Alcoholism', 'Hypertension-of diagnoses be-Liver Cirrhosis', 'Hypertension-of diagnoses be-Diabetes Mellitus', 'Obesity-affected-Hyperlipidemia, Familial Combined', 'Obesity-affected-APOB', 'APOB-elevated level of be-Hyperlipidemia, Familial Combined', 'Glucose-classify-Diabetes Mellitus', 'Glucose-classify-Glucose Intolerance', 'Glucose-associated-Memory Disorders', 'Memory Disorders-associated-Glucose', 'Glucose-associated-Atrophy', 'Atrophy-associated-Glucose', 'Neoplasms-assessed-Colorectal Neoplasms', 'Alzheimer Disease-compared-Supranuclear Palsy, Progressive', 'APOE-compared-Supranuclear Palsy, Progressive', 'APOE-be in-Supranuclear Palsy, Progressive', 'APOE-be with-Alzheimer Disease', 'Polycystic Ovary Syndrome-considered-Metabolic Diseases', 'Alzheimer Disease-be frequent with-Supranuclear Palsy, Progressive', 'Polycystic Ovary Syndrome-considered-Obesity', 'Polycystic Ovary Syndrome-considered-Hyperinsulinism', 'Polycystic Ovary Syndrome-considered-Cardiovascular Diseases', 'Supranuclear Palsy, Progressive-carry-APOE', 'Diabetes Mellitus-diagnosis of be-Kidney Diseases', 'ACE-concomitant use of be-Kidney Diseases', 'Metabolic Diseases-risk for-Cardiovascular Diseases', 'Hyperinsulinism-increase-Cardiovascular Diseases', 'Stroke-emerge-Death', 'Heart Failure-emerge-Death', 'CRP-emerge-Death', 'Death-underlie-Inflammation', 'Cholesterol-underlie-Inflammation', 'Digoxin-recommended-ACE', 'Heart Failure-recommended-ACE', 'Digoxin-recommended-Heart Failure', 'Digoxin-recommended-Atrial Fibrillation', 'Valproic Acid-include-Signs and Symptoms, Digestive', 'Valproic Acid-include-Tremor', 'Necrosis-cytokine in-Arthritis, Rheumatoid', 'Infliximab-targeted-Necrosis', 'Infliximab-targeted-Arthritis, Rheumatoid', 'INS-develop-Hyperglycemia', 'Inflammation-develop-Atherosclerosis', 'Infarction-develop-Atherosclerosis', 'Inflammation-combined-IL6', 'Infarction-combined-IL6', 'Acarbose-tolerated-Flatulence', 'Acarbose-tolerated-Diarrhea', 'PTH-treat-Osteoporosis', 'Fish Oils-reveal-Cardiac Output, Low', 'Arthritis, Rheumatoid-assess-Autoimmune Diseases', 'Colitis, Ulcerative-assess-Autoimmune Diseases', 'Colitis, Ulcerative-include-Autoimmune Diseases', 'Psoriasis-assess-Autoimmune Diseases', 'Psoriasis-include-Autoimmune Diseases', 'Lupus Erythematosus, Systemic-assess-Autoimmune Diseases', 'Multiple Sclerosis-assess-Autoimmune Diseases', 'Migraine Disorders-assess-Autoimmune Diseases', 'Migraine Disorders-include-Autoimmune Diseases', 'Arthritis-characterized-Fatty Acids, Omega-6', 'Crohn Disease-characterized-Fatty Acids, Omega-6', 'Colitis, Ulcerative-characterized-Fatty Acids, Omega-6', 'Lupus Vasculitis, Central Nervous System-characterized-Fatty Acids, Omega-6', 'Autoimmune Diseases-characterized-Fatty Acids, Omega-6', 'KLK6-measure-Alzheimer Disease', 'KLK6-measure-Noncommunicable Diseases', 'Arthritis, Rheumatoid-assess-Fish Oils', 'Arthritis, Rheumatoid-include-Fish Oils', 'Colitis, Ulcerative-assess-Fish Oils', 'Colitis, Ulcerative-include-Fish Oils', 'Psoriasis-assess-Fish Oils', 'Psoriasis-include-Fish Oils', 'Lupus Erythematosus, Systemic-assess-Fish Oils', 'Lupus Erythematosus, Systemic-include-Fish Oils', 'Multiple Sclerosis-assess-Fish Oils', 'Multiple Sclerosis-include-Fish Oils', 'Migraine Disorders-assess-Fish Oils', 'Migraine Disorders-include-Fish Oils', 'LEP-occur-Obesity', 'LEP-occur-Cushing Syndrome', 'LEP-occur-Lipodystrophy', 'Atherosclerosis-combined-Diabetes Mellitus, Type 2', 'Atherosclerosis-known-Diabetes Mellitus, Type 2', 'Bone Marrow Diseases-be in-Leukemia, Myeloid, Acute', 'Tauopathies-delay-Alzheimer Disease', 'LEP-cause-Neurologic Manifestations', 'Lung Neoplasms-suppress-Death', 'Diabetes Mellitus, Type 2-suffer-Coronary Artery Disease', 'Lung Neoplasms-correlated-Stomach Neoplasms', 'Diabetes Mellitus, Type 2-suffer-Myocardial Infarction', 'Death-correlated-Stomach Neoplasms', 'CLU-increase-Diabetes Mellitus, Type 2', 'CLU-strong indication of-Aneurysm', 'CLU-represent-Aneurysm', 'Polysaccharides-prevent-Neoplasm Invasiveness', 'Polysaccharides-prevent-Pneumonia', 'CLU-be higher from-Kidney Diseases', 'CLU-correlated-Proteinuria', 'Headache Disorders, Secondary-take-GH1', 'GH1-take-Arthralgia', 'Diabetes Mellitus-occur in-GH1', 'Glucose Intolerance-occur in-GH1', 'Diabetes Mellitus-confined-GH1', 'Glucose Intolerance-confined-GH1', 'Metabolic Syndrome-be frequent with-Obesity', 'Alzheimer Disease-find-Cardiovascular Diseases', 'APOE-occur in-Alzheimer Disease', 'APOE-find-Cardiovascular Diseases', 'Heart Failure-based-Cardiovascular Diseases', 'Heart Failure-prevent-Cardiovascular Diseases', 'Heart Failure-based-Ventricular Dysfunction, Left', 'Cardiovascular Diseases-prevent-Ventricular Dysfunction, Left', 'Heart Failure-based-ACE', 'ACE-prevent-Cardiovascular Diseases', 'APOE-examine-Alzheimer Disease', 'APOE-examine-Dementia', 'APOE-examine-Cardiovascular Diseases', 'PCMT1-contribute-Nerve Degeneration', 'Arthritis, Rheumatoid-termed-Cachexia', 'GH1-play cachexia in-Arthritis, Rheumatoid', 'GH1-play role in-Arthritis, Rheumatoid', 'GH1-play-Cachexia', 'GH1-termed-Cachexia', 'Ghrelin-accompanied-GGH', 'Obesity-increase-GGH', 'Diabetes Mellitus-classify-Glucose Intolerance', 'Glucose-diagnose-Diabetes Mellitus', 'Tauopathies-resemble-Alzheimer Disease', 'Bone Diseases, Metabolic-contribute-Bone Neoplasms', 'rs63750424-cause-Tauopathies', 'KL-exhibit-Bone Diseases, Metabolic', 'rs63750424-resemble-Alzheimer Disease', 'KL-contribute-Bone Neoplasms', 'Infliximab-cause-Coronary Vasospasm', 'Infliximab-cause-Arrhythmias, Cardiac', 'Infliximab-cause-Coronary Artery Disease', 'N-Acetylneuraminic Acid-estimated-Diabetes Mellitus', 'N-Acetylneuraminic Acid-obtained-Diabetes Mellitus', 'Infliximab-lead-Ischemia', 'Infliximab-involved-Ischemia', 'Dementia-between association be-Inflammation', 'Alzheimer Disease-combined-Dementia, Vascular', 'CRP-combined-Alzheimer Disease', 'CRP-combined-Dementia, Vascular', 'Death-correlated-Heart Failure', 'Isoprostanes-improve-Alzheimer Disease', 'Death-correlated-CRP', 'INS-stimulate matrix synthesis in-Cartilage Diseases', 'INS-stimulate suppression in-Cartilage Diseases', 'Cartilage Diseases-overcome-INS', 'INS-overcome-Diabetes Mellitus', 'Xerostomia-relieve-Headache Disorders, Secondary', "Headache Disorders, Secondary-relieve-Sjogren's Syndrome", 'Xerostomia-relieve-Cyclosporine', 'Cyclosporine-relieve-Headache Disorders, Secondary', 'MAPT-demonstrate-Neurodegenerative Diseases', "Cyclosporine-relieve-Sjogren's Syndrome", 'MAPT-demonstrate-Neurotoxicity Syndromes', 'Carcinoma, Basal Cell-seen-Carcinoma, Squamous Cell', 'Diabetes Mellitus-set-Glucose', 'Glucose-define as-Glucose Intolerance', 'VWF-seen-Glucose Intolerance', 'Bone Cysts-associated-Osteoporosis', 'Osteoporosis-associated-Bone Cysts', 'KL-base-Bone Diseases, Metabolic', 'KL-associated-Bone Diseases, Metabolic', 'Bone Diseases, Metabolic-associated-KL', 'KL-base-Bone Cysts', 'KL-associated-Bone Cysts', 'Bone Cysts-associated-KL', 'KL-associated-Spondylosis', 'Spondylosis-associated-KL', 'NGF-differ-Dementia', 'NGF-differ-Alzheimer Disease', 'EPO-improve function In-Anemia', 'EPO-improve function In-Renal Insufficiency', 'EPO-accelerate-Acute Kidney Injury', 'Anemia-advance-Heart Diseases', 'Cardiomyopathy, Hypertrophic-reduce-Death', 'Cardiomyopathy, Hypertrophic-advance-Heart Diseases', 'Death-advance-Heart Diseases', 'EPO-bring-Cardiomyopathy, Hypertrophic', 'EPO-reduce-Death', 'EPO-advance-Heart Diseases', 'SDHB-associated-Mitochondrial Encephalomyopathies', 'Mitochondrial Encephalomyopathies-associated-SDHB', 'SDHB-associated-Optic Atrophy', 'Optic Atrophy-associated-SDHB', 'PLTP-correlate-Obesity', 'PLTP-correlate-Diabetes Mellitus', 'PLTP-correlate-Coronary Artery Disease', 'Growth Disorders-reduce-Neutropenia', 'CRP-identify-Angina, Unstable', 'CRP-identify-Myocardial Infarction', 'CRP-identify-Stroke', 'CRP-identify-Death, Sudden', 'Heparin, Low-Molecular-Weight-highlight-Hip Fractures', 'Angina, Unstable-produce-Ischemia', 'Angina, Unstable-produce-Hemorrhage', 'Ischemia-compare-Heparin', 'Ischemia-reduce-Heparin', 'Ischemia-produce-Heparin', 'Hemorrhage-reduce-Heparin', 'Hemorrhage-produce-Heparin', 'Endocrine System Diseases-deteriorate-Glucose Intolerance', 'Endocrine System Diseases-lead-Cystic Fibrosis', 'Endocrine System Diseases-revert-INS', 'Glucose Intolerance-revert-INS', 'Cystic Fibrosis-revert-INS', 'Diabetes Mellitus-be with-Glucose', 'Glucose Intolerance-include-Diabetes Mellitus', 'MPG-found-Ovarian Neoplasms', 'MPG-found-Heart Arrest', 'Obesity, Abdominal-associated-Hypertension', 'Hypertension-associated-Obesity, Abdominal', 'Obesity, Abdominal-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-Obesity, Abdominal', 'Obesity, Abdominal-promote-Cardiomyopathy, Hypertrophic', 'Hypertension-promote-Cardiomyopathy, Hypertrophic', 'Diabetes Mellitus-promote-Cardiomyopathy, Hypertrophic', 'Glucosephosphate Dehydrogenase Deficiency-result-Hemolysis', 'Glucose-promote-Cardiomyopathy, Hypertrophic', 'rs5030868-result-Hemolysis', 'CRH-implicate-Acne Vulgaris', 'CRH-implicate-Dermatitis, Seborrheic', 'CRH-implicate-Skin Diseases', 'ACE-related-Cerebrovascular Disorders', 'Dementia-show-Alzheimer Disease', 'INS-determined-Seizures', 'INS-determined-Obesity', 'Prostatic Hyperplasia-progress-Prostatic Neoplasms', 'CYP3A4-identify men with-Prostatic Hyperplasia', 'CYP3A4-identify-Prostatic Neoplasms', 'Meningeal Neoplasms-involve-GCG', 'Respiratory Tract Infections-associate-Diabetes Mellitus', 'Diabetes Mellitus-associate-Respiratory Tract Infections', 'Respiratory Tract Infections-associate-Airway Obstruction', 'Airway Obstruction-associate-Respiratory Tract Infections', 'Respiratory Tract Infections-associate-Glucose', 'Glucose-associate-Respiratory Tract Infections', 'Diabetes Mellitus-associated-Respiratory Tract Infections', 'Respiratory Tract Infections-associated-Diabetes Mellitus', 'Airway Obstruction-associated-Respiratory Tract Infections', 'Respiratory Tract Infections-associated-Airway Obstruction', 'Glucose-associated-Respiratory Tract Infections', 'Respiratory Tract Infections-associated-Glucose', 'Cholecalciferol-prevent-Osteoporotic Fractures', 'Cardiovascular Diseases-increase-Glucose', 'Triglycerides-decrease-Fasciculation', 'Triglycerides-contribute-Glucose Metabolism Disorders', 'Triglycerides-assess-INS', 'Obesity-assess-INS', 'Obesity-quantify-Triglycerides', 'Death-include-ALB', 'Glucose Intolerance-attributed-INS', 'Diabetes Mellitus, Type 2-signify-INS', 'Obesity-promoted-INS', 'Obesity-signify-INS', 'Dyslipidemias-attributed-INS', 'INS-promoted-Obesity, Abdominal', 'Communicable Diseases-increased-Glucose', 'Glucose-diagnostic threshold for-Diabetes Mellitus', 'Glucose-reach-Diabetes Mellitus', 'Glucose-increased-Cardiovascular Diseases', 'Cholesterol-characterized-Coronary Artery Disease', 'Cholesterol-be important predictors of-Coronary Artery Disease', 'Cholesterol-be important predictors of-Death', 'Dinoprostone-induce-Periodontal Diseases', 'PTHLH-detected-Adenoma', 'PTHLH-detected-Hyperplasia', 'PTHLH-detected-Kidney Failure, Chronic', 'Fever-cause-Heart Diseases', 'Trastuzumab-tolerated-Fever', 'Trastuzumab-cause-Heart Diseases', 'Cardiotoxicity-be main concern in-Heart Diseases', 'Hypoaldosteronism-present-Dyspnea', 'Hypoaldosteronism-take-Lisinopril', 'Lisinopril-present-Dyspnea', 'Bone Neoplasms-prevent-Fractures, Bone', 'Bone Neoplasms-remain-GH1', 'Fractures, Bone-remain-GH1', 'Fractures, Bone-increased-Hip Fractures', 'Renal Insufficiency, Chronic-develop-Acidosis', 'Renal Insufficiency, Chronic-develop-Hyperkalemia', 'Renal Insufficiency, Chronic-develop-Infections', 'Diabetic Nephropathies-develop-Acidosis', 'Diabetic Nephropathies-develop-Hyperkalemia', 'Diabetic Nephropathies-develop-Infections', 'Acidosis-develop-Infections', 'Hyperkalemia-develop-Infections', 'Hyperkalemia-reported-Acidosis', 'Hyperglycemia-measured-Lipopolysaccharides', 'Hyperinsulinism-measured-Lipopolysaccharides', 'Obesity-reduce-Cardiovascular Diseases', 'CRP-relate-Cerebral Infarction', 'Malabsorption Syndromes-reverse-PTH', 'Hyperparathyroidism-used-PTH', 'Hyperparathyroidism-reverse-PTH', 'CRP-relate-Ischemia', 'Coronary Artery Disease-predict-Stroke', 'GPT-associated-Hepatitis C', 'Hepatitis C-associated-GPT', 'GPT-associated-Viremia', 'Viremia-associated-GPT', 'Cholesterol-predict-Stroke', 'Cholesterol-designed-Coronary Artery Disease', 'Cholesterol-designed-Stroke', 'Hyperglycemia-enhance-Glucose Metabolism Disorders', 'Fibrosis-provide-Carcinoma, Hepatocellular', 'Hypotension-occur-Heart Failure', 'Neuronal Ceroid-Lipofuscinoses-be group of-Neurodegenerative Diseases', 'Hypotension-occur-ACE', 'TRPV1-function-Eicosanoids', 'Lipofuscin-be group of-Neurodegenerative Diseases', 'Neuralgia-associated-Renal Insufficiency', 'Renal Insufficiency-associated-Neuralgia', 'Diabetic Neuropathies-associated-Renal Insufficiency', 'Renal Insufficiency-associated-Diabetic Neuropathies', 'Coronary Artery Disease-remain despite-Atherosclerosis', 'Pain-associated-Renal Insufficiency', 'Renal Insufficiency-associated-Pain', 'Pruritus-associated-Renal Insufficiency', 'Renal Insufficiency-associated-Pruritus', 'Coronary Artery Disease-remain-Atherosclerosis', 'Coronary Artery Disease-remain-Cholesterol', 'Renal Insufficiency-associated-Urinary Incontinence', 'Urinary Incontinence-associated-Renal Insufficiency', 'Capsaicin-shown-Neuralgia', 'Capsaicin-shown-Diabetic Neuropathies', 'Capsaicin-shown-Pain', 'Capsaicin-shown-Pruritus', 'Capsaicin-shown-Renal Insufficiency', 'Capsaicin-associated-Renal Insufficiency', 'Renal Insufficiency-associated-Capsaicin', 'Capsaicin-shown-Urinary Incontinence', 'Diabetes Mellitus, Type 2-controlled-Hypotension', 'Diabetes Mellitus, Type 2-controlled-Glucose', 'Sugars-shown-Alzheimer Disease', 'Sugars-shown-Diabetes Mellitus', 'Coronary Artery Disease-attributed-Cholesterol', 'Cardiovascular Diseases-contrast-Diabetes Mellitus', 'Diabetes Mellitus-remain-Heart Diseases', 'Heart Diseases-associate-CRP', 'CRP-associate-Heart Diseases', 'Cardiovascular Diseases-contrast-Hyperglycemia', 'Cardiovascular Diseases-contrast-Glucose Intolerance', 'Cardiovascular Diseases-contrast-Glucose', 'Heart Diseases-increase-Prostatic Hyperplasia', 'NPEPPS-increase-Prostatic Hyperplasia', 'INS-appear-Hyperglycemia', 'GH1-evaluated-Growth Disorders', 'GH1-evaluated-Heart Diseases', 'GH1-evaluated-Crohn Disease', 'Alzheimer Disease-linked-Neurodegenerative Diseases', 'GH1-evaluated-Short Bowel Syndrome', 'Neoplasms-show-GHRH', 'Lymphoma-show-GHRH', 'Myelodysplastic Syndromes-differentiate-Leukemia, Myeloid, Acute', 'DAPK3-differentiate-Myelodysplastic Syndromes', 'DAPK3-differentiate-Leukemia, Myeloid, Acute', 'Werner Syndrome-interact-Neoplasms', 'Galactosemias-be in-Sugars', 'Stroke-appear-Renal Insufficiency', 'ACE-specific benefit in-Diabetes Mellitus', 'Stroke-appear-Proteinuria', 'Stroke-appear-Death', 'Stroke-appear-Heart Failure', 'Cerebrovascular Disorders-evidence-APOE', 'ACE-reduce-Death', 'Stroke-appear-ACE', 'Hypertension-report-Cholesterol', 'Hypercholesterolemia-report-Cholesterol', 'Osteoporosis-treat-Hypercalcemia', 'Glomerulonephritis-followed-Kidney Diseases', 'Glomerulonephritis-followed-CD79A', 'HIV Infections-reported-Hearing Disorders', 'Valproic Acid-be recent addition to-Status Epilepticus', 'Valproic Acid-be recent addition to-Hypotension', 'Nucleosides-reported-Hearing Disorders', 'Alzheimer Disease-find-Hypothalamic Neoplasms', 'MAPT-increased-Stroke', 'MAPT-implicated-Dementia, Vascular', 'Hyperhomocysteinemia-offer-Arteriosclerosis', 'Hyperhomocysteinemia-explain-Cholesterol', 'Arteriosclerosis-explain-Cholesterol', 'Cholesterol-reduce-Myocardial Infarction', 'Cholesterol-reduce-Stroke', 'PTH-reduce-Bone Neoplasms', 'PTH-reduce-Osteoporosis', 'SLC6A3-extend-Neurodegenerative Diseases', 'SLC6A3-extend-Dementia', 'BABAM2-downregulated-Adenoma', 'Calculi-be with-Cholestasis', 'BABAM2-downregulated-Pheochromocytoma', 'Blood Platelet Disorders-induced-Ristocetin', 'Neuronal Ceroid-Lipofuscinoses-lead-Brain Damage, Chronic', 'Genetic Diseases, Inborn-lead to-Brain Damage, Chronic', 'TPP1-lead-Brain Damage, Chronic', 'Dyspnea-associated-CRP', 'CRP-associated-Dyspnea', 'Fever-associated-CRP', 'CRP-associated-Fever', 'Aneurysm-found-Atherosclerosis', 'Aneurysm-detected-Glycosaminoglycans', 'Atherosclerosis-detected-Glycosaminoglycans', 'Cardiotoxicity-used-Neoplasms', 'Doxorubicin-used-Neoplasms', 'INS-have result in-Diabetes Mellitus', 'Gangliosides-shed-Neoplasms', 'Gangliosides-shed-Necrosis', 'Glucose-be low in-Coma', 'Rhinitis, Allergic-based-Drug Hypersensitivity', 'Rhinitis, Allergic-based-RNASE3', 'Drug Hypersensitivity-based-RNASE3', 'Rhinitis, Allergic-based-Leukotrienes', 'Drug Hypersensitivity-based-Leukotrienes', 'Drug-Related Side Effects and Adverse Reactions-arise-Death', 'Digoxin-arise-Death', 'Digoxin-include-Atrial Fibrillation', 'Digoxin-include-Heart Failure', 'Alzheimer Disease-provoke-Neurodegenerative Diseases', 'Infections-release-GAST', 'GAST-release-Ulcer', 'MAPT-provoke-Neurodegenerative Diseases', 'Myocardial Infarction-be higher among-Diabetes Mellitus', 'Inflammation-related-Cardiovascular Diseases', 'Heart Failure-be higher among-Diabetes Mellitus', 'Hypertension-take-INS', 'Myocardial Infarction-take-INS', 'Heart Failure-take-INS', 'Angina Pectoris-document-Myocardial Infarction', 'Atherosclerosis-cause of-Myocardial Infarction', 'Glucose Intolerance-render-Diabetes Mellitus, Type 2', 'Angina Pectoris-defined-Death', 'Glucose-diagnosed-Glucose Intolerance', 'Myocardial Infarction-document-Death', 'Glucose-diagnosed-Diabetes Mellitus, Type 2', 'Glucose-render-Diabetes Mellitus, Type 2', 'Angina Pectoris-defined-Cholesterol', 'Myocardial Infarction-document-Cholesterol', 'Myocardial Infarction-consist-Fibrosis', 'Myocardial Infarction-consist-Inflammation', 'Stroke-consist-Fibrosis', 'Death-adjusted-Cholesterol', 'Stroke-consist-Inflammation', 'Cardiovascular Diseases-consist-Fibrosis', 'Cardiovascular Diseases-consist-Inflammation', 'Atherosclerosis-consist of-Cholesterol', 'INS-be secondary to-Glucose', 'INS-seen-Glucose', 'INS-impaired-Glucose', 'Myocardial Infarction-consist-Cholesterol', 'Stroke-consist-Cholesterol', 'Cardiovascular Diseases-consist of-Cholesterol', 'Hyperinsulinism-be secondary to-Glucose', 'Hyperinsulinism-seen-Glucose', 'Gemfibrozil-resurrect-Atherosclerosis', 'Gemfibrozil-show-Coronary Artery Disease', 'Cataract-occur-FTL', 'Weight Loss-prevent-Glucose Intolerance', 'Esophageal Neoplasms-relieve-Gastroesophageal Reflux', 'Weight Loss-increase-INS', 'INS-reduction in-Glucose', 'INS-prevent-Glucose Intolerance', 'INS-promoted-Diabetes Mellitus, Type 2', 'Glucose-elicited-INS', 'SLC18A2-linked-Substance-Related Disorders', 'Fatty Acids-play role in-INS', 'Heart Failure-suffer-Cardiomyopathy, Hypertrophic', 'Fatty Acids-seen-Obesity', 'Heart Failure-suffer-Hypertension', 'Fatty Acids-seen-Diabetes Mellitus', 'Heart Failure-suffer-Enalapril', 'Anemia-be independent-Bone Marrow Diseases', 'Diabetes Mellitus-viewed-Obesity', 'Diabetes Mellitus-viewed-INS', 'Diabetes Mellitus-increase-INS', 'Diabetes Mellitus-determine-Hyperglycemia', 'Ischemia-associated-Renal Artery Obstruction', 'Renal Artery Obstruction-associated-Ischemia', 'REN-associated-Renal Artery Obstruction', 'Renal Artery Obstruction-associated-REN', 'Hypertrophy-affected-MSTN', 'Cerebral Amyloid Angiopathy-be major cause of-Hemorrhage', 'Cerebral Amyloid Angiopathy-associated-APOE', 'APOE-associated-Cerebral Amyloid Angiopathy', 'Hemorrhage-be in-Venous Thrombosis', 'Peripheral Arterial Disease-directed-Diabetes Mellitus', 'Peripheral Arterial Disease-directed-Cholesterol', 'INS-lead-Diabetes Mellitus, Type 2', 'Stroke-carry-APOE', 'Polycystic Kidney Diseases-be with-Kidney Failure, Chronic', 'Polycystic Kidney Diseases-reach-Kidney Failure, Chronic', 'PKD2-reach-Kidney Failure, Chronic', 'Neoplasms-help-BRCA1', 'Pain-receive-Valproic Acid', 'Hypertension-suggest-Death', 'Hypertension-suggest-Cholesterol', 'Hypertension-raise-Coronary Artery Disease', 'Cholesterol-raise-Coronary Artery Disease', 'Cardiovascular Diseases-decrease-Kidney Failure, Chronic', 'Myocardial Infarction-seen-Diabetes Mellitus', 'Cardiovascular Diseases-decrease-Retinal Diseases', 'Myocardial Infarction-seen-Enalapril', 'Cardiovascular Diseases-decrease-Peripheral Vascular Diseases', 'Enalapril-seen-Diabetes Mellitus', 'Glucose-reduce-Cardiovascular Diseases', 'SOD1-identified-Amyotrophic Lateral Sclerosis', 'SOD1-identified-Liver Neoplasms', 'Hypothalamic Neoplasms-find-Acromegaly', 'Neoplasms-find-Acromegaly', 'GHRH-isolated-Neoplasms', 'GHRH-find-Acromegaly', 'Hyperhomocysteinemia-play-Glutathione', 'Aneurysm-play-Glutathione', 'Stroke-decrease-Hypertension', 'Death-decrease-Hypertension', 'Enalapril-decrease-Stroke', 'Enalapril-decrease-Death', 'Enalapril-decrease-Hypertension', 'Cardiovascular Diseases-reduce-Hypertension', 'Death-reduce-Hypertension', 'Myocardial Infarction-be in-Hypertension', 'Myocardial Infarction-reduce-Hypertension', 'Stroke-reduce-Hypertension', 'GHRH-measured-Neoplasms', 'Enalapril-reduce-Cardiovascular Diseases', 'HSPA8-contribute-Retinal Diseases', 'Enalapril-reduce-Myocardial Infarction', 'Enalapril-reduce-Hypertension', 'Cholesterol-increase-Atherosclerosis', 'Cholesterol-increase-Stroke', 'Cholesterol-show-Hypertension', 'Neuroblastoma-show-Drug-Related Side Effects and Adverse Reactions', 'Stroke-extrapolate-Myocardial Infarction', 'Stroke-extrapolate-Cholesterol', 'Stroke-lowering-Cholesterol', 'Cholesterol-lowering-Myocardial Infarction', 'Tramadol-prove-Obesity', 'Tramadol-prove-Renal Insufficiency', 'Cholesterol-predispose-Stroke', 'Cholesterol-predispose-Cerebral Infarction', 'Hypertension-associated-Cerebral Infarction', 'Cerebral Infarction-associated-Hypertension', 'Coronary Artery Disease-associated-Cerebral Infarction', 'Cerebral Infarction-associated-Coronary Artery Disease', 'Cardiomegaly-associated-Cerebral Infarction', 'Cerebral Infarction-associated-Cardiomegaly', 'Dementia-indicate-Atherosclerosis', 'Retinal Diseases-associated-Lipofuscin', 'Lipofuscin-associated-Retinal Diseases', 'Lipofuscin-associated-Stargardt Disease', 'Stargardt Disease-associated-Lipofuscin', 'Rhabdomyolysis-lead-Renal Insufficiency', 'Rhabdomyolysis-reported-Gemfibrozil', 'Renal Insufficiency-receive-Gemfibrozil', 'Rhabdomyolysis-reported-Cyclosporine', 'Renal Insufficiency-receive-Cyclosporine', 'Creutzfeldt-Jakob Syndrome-be with-PRNP', 'Leukotrienes-be major players in-Inflammation', 'Brain Injury, Chronic-result-Memory Disorders', 'Brain Injury, Chronic-result-Glucose', 'Cardiomyopathies-include-Ischemia', 'Cardiomyopathies-induced-Ischemia', 'Cardiomyopathies-include-Coronary Occlusion', 'Cardiomyopathies-induced-Coronary Occlusion', 'Shock-include-Cardiomyopathies', 'Heart Failure-include-Ischemia', 'Heart Failure-induced-Ischemia', 'Heart Failure-include-Coronary Occlusion', 'Heart Failure-induced-Coronary Occlusion', 'Shock-include-Heart Failure', 'Cardiomyopathies-include-Heart Failure', 'Doxorubicin-include-Cardiomyopathies', 'Doxorubicin-include-Heart Failure', 'Coronary Occlusion-cardiomyopathy from-Doxorubicin', 'NGF-prevent-Atrophy', 'NGF-observed-Alzheimer Disease', 'APOE-find-Aneurysm', 'Dementia-influence-Alzheimer Disease', 'APOE-factor for-Dementia', 'APOE-influence-Alzheimer Disease', 'Hyperinsulinism-be due-INS', 'NR3C2-involved-Hypothalamic Neoplasms', 'NR3C2-underlie-Hypothalamic Neoplasms', 'NR3C2-affect-Hypothalamic Neoplasms', 'Death-reduced-Abciximab', 'Myocardial Infarction-reduced-Abciximab', 'Obesity-of pathobiology be-Diabetes Mellitus, Type 2', 'TNF-play-Glucose Metabolism Disorders', 'Fatty Acids, Essential-play-Glucose Metabolism Disorders', 'Cholesterol-associated-Lung Neoplasms', 'Lung Neoplasms-associated-Cholesterol', 'Inflammation-predict-Cardiovascular Diseases', 'CRP-predict-Cardiovascular Diseases', 'Myocardial Infarction-requested-Pneumococcal Infections', 'Cholesterol-requested-Myocardial Infarction', 'Epirubicin-comprise-Lymphoma, Non-Hodgkin', 'Coronary Artery Disease-obtained-Stroke', 'Neoplasms-equipped-GAST', 'Stomach Neoplasms-equipped-GAST', 'Pain-applied-Hyperalgesia', 'Capsaicin-applied-Pain', 'Ischemia-be in-Coronary Artery Disease', 'Hyperlipoproteinemia Type II-be with-Coronary Artery Disease', 'Ischemia-be in-Hyperlipoproteinemia Type II', 'Cholesterol-be with-Coronary Artery Disease', 'Ischemia-be in-Cholesterol', 'Pancreatitis-lead-Hyperglycemia', 'Pancreatitis-lead-Diabetes Mellitus', 'CRP-classified-Death', 'CRP-classified-Heart Rupture', 'PWAR4-include-Alzheimer Disease', 'PWAR4-include-Parkinson Disease', 'BDNF-reduced-Alzheimer Disease', 'CHAT-decreased-Parkinson Disease', 'Bone Diseases, Metabolic-evaluate-Osteogenesis Imperfecta', 'Bone Diseases, Metabolic-measured-BGLAP', 'Osteogenesis Imperfecta-measured-BGLAP', 'CAT-implicated-Inflammation', 'CAT-implicated-Neoplasms', 'Alzheimer Disease-include-Nerve Degeneration', 'Diabetes Mellitus-studied-Proteinuria', 'Diabetes Mellitus-evaluate-Proteinuria', 'Nerve Degeneration-composed-MAPT', 'Diabetes Mellitus-studied-Nervous System Diseases', 'Diabetes Mellitus-evaluate-Nervous System Diseases', 'Diabetes Mellitus-studied-Blood Glucose', 'Diabetes Mellitus-evaluate-Blood Glucose', 'Diabetes Mellitus, Type 2-characterised-Insulin Resistance', 'Diabetes Mellitus, Type 2-characterised-INS', 'Diabetes Mellitus-warranted-INS', 'Disease Progression-warranted-INS', 'GH1-found-Edema', 'GH1-found-Arthralgia', 'Diabetes Mellitus, Type 2-affected-INS', 'Diabetes Mellitus-affected-INS', 'ALLC-treat-Alzheimer Disease', 'ALLC-treat-HIV Infections', 'ALLC-treat-Diabetic Neuropathies', 'ALLC-treat-Ischemia', 'Vision Disorders-be in-Diabetes Mellitus', 'Venous Thromboembolism-associated-Hemorrhage', 'Hemorrhage-associated-Venous Thromboembolism', 'Heparin, Low-Molecular-Weight-used-Venous Thromboembolism', 'IL1RN-associated-Neoplasms', 'Neoplasms-associated-IL1RN', 'Periodontitis-increase-HGF', 'Digoxin-given-Atrial Fibrillation', 'Digoxin-given-Gout', 'Gentamicins-prevent-Kidney Diseases', 'Gentamicins-prevent-Hearing Disorders', 'RECQL4-be down regulated from-Rothmund-Thomson Syndrome', 'RECQL4-be down regulated from-Werner Syndrome', 'RECQL4-identified-Rothmund-Thomson Syndrome', 'Kidney Diseases-associated-Retinal Diseases', 'Retinal Diseases-associated-Kidney Diseases', 'RECQL4-identified-Genetic Diseases, Inborn', 'INS-associated-Retinal Diseases', 'Retinal Diseases-associated-INS', 'Kidney Diseases-of presence be-Diabetes Mellitus', 'Macular Edema-associated-Hypertension', 'Hypertension-associated-Macular Edema', 'Macular Edema-associated-Diabetes Mellitus, Type 1', 'Diabetes Mellitus, Type 1-associated-Macular Edema', 'Macular Edema-associated-Cholesterol', 'Cholesterol-associated-Macular Edema', 'Lipopolysaccharides-reflect-Graft vs Host Disease', 'Lipopolysaccharides-reflect-Infections', 'Stroke-differentiate-Alzheimer Disease', 'Neoplasms-analyzed-KLK3', 'Prostatic Neoplasms-analyzed-KLK3', 'Cyclosporine-used-Autoimmune Diseases', 'Cyclosporine-select autoimmune diseases such-Arthritis, Rheumatoid', 'Cyclosporine-used-Arthritis, Rheumatoid', 'Cough-converting-Pneumonia', 'Cough-induce-Pneumonia', 'Cough-induce-ACE', 'ACE-converting-Pneumonia', 'Docosahexaenoic Acids-associated-Alcoholism', 'Alcoholism-associated-Docosahexaenoic Acids', 'Docosahexaenoic Acids-associated-Cystic Fibrosis', 'Cystic Fibrosis-associated-Docosahexaenoic Acids', 'Docosahexaenoic Acids-associated-Phenylketonurias', 'Phenylketonurias-associated-Docosahexaenoic Acids', 'Docosahexaenoic Acids-associated-Adrenoleukodystrophy', 'Adrenoleukodystrophy-associated-Docosahexaenoic Acids', 'Pneumococcal Infections-recommended-Neoplasm Invasiveness', 'Pneumococcal Infections-prevent-Neoplasm Invasiveness', 'Polysaccharides-recommended-Neoplasm Invasiveness', 'Infections-recommended-Pneumococcal Infections', 'Alzheimer Disease-share-Huntington Disease', 'APOE-implicated-Huntington Disease', 'APOE-share-Huntington Disease', 'Obesity-ameliorated-Death', 'Obesity-ameliorated-Seizures', 'Neoplasms-enhance-Prostatic Neoplasms', 'Weight Loss-ameliorated-Seizures', 'Gallstones-exhibit-Diabetes Mellitus', 'Gallstones-exhibit-Glucose', 'Dementia-be with-Stroke', 'Lymphoma-for myeloma be-Xanthomatosis, Cerebrotendinous', 'Stroke-include-Atherosclerosis', 'Ischemia-include-Atherosclerosis', 'Polyuria-needed-INS', 'Weight Loss-needed-INS', 'Hypotension-needed-INS', 'Myoclonus-modified-INS', 'INS-use-Nervous System Diseases', 'INS-avoid-Nervous System Diseases', 'INS-use-Retinal Diseases', 'INS-avoid-Retinal Diseases', 'INS-use-Kidney Diseases', 'INS-avoid-Kidney Diseases', 'Cholesterol-associated-Endometrial Neoplasms', 'Endometrial Neoplasms-associated-Cholesterol', 'Cholesterol-associated-Pulmonary Embolism', 'Pulmonary Embolism-associated-Cholesterol', 'Cholesterol-maintain-Venous Thrombosis', 'CD4-be within-Infections', 'INS-associated-Wounds and Injuries', 'Wounds and Injuries-associated-INS', 'Blood Platelet Disorders-stabilize-Alzheimer Disease', 'MAPT-stabilize-Blood Platelet Disorders', 'MAPT-become-Alzheimer Disease', 'Inflammation-be component of-Chronic Disease', 'Neoplasms-be in-Neoplastic Syndromes, Hereditary', 'GH1-observed-Neoplasms', 'Parkinson Disease-be with-Dementia', 'Neoplasms-known-Werner Syndrome', 'N-Acetylneuraminic Acid-increased-Neoplasms', 'N-Acetylneuraminic Acid-increased-Alcoholism', 'N-Acetylneuraminic Acid-increased-Diabetes Mellitus', 'N-Acetylneuraminic Acid-increased-Kidney Failure, Chronic', 'N-Acetylneuraminic Acid-increased-Glomerulonephritis', 'Death-reduce-Hypotension', 'INS-reduce-Death', 'INS-reduce term mortality despite-Hypotension', 'ALB-include-Inflammation', 'Glucose Intolerance-occur because-Glucose', 'Heart Failure-be in-Breast Neoplasms', 'Diabetes Mellitus-treat-Hypertension', 'Heart Failure-related-Ventricular Dysfunction, Left', 'Digoxin-control-ACE', 'Heart Failure-control-ACE', 'Atrial Fibrillation-control-ACE', 'Digoxin-based-Heart Failure, Diastolic', 'Digoxin-based-Heart Failure', 'Digoxin-control-Ventricular Dysfunction, Left', 'Heart Failure-associate-Atrial Fibrillation', 'Atrial Fibrillation-associate-Heart Failure', 'Heart Failure-related-Atrial Fibrillation', 'Ventricular Dysfunction, Left-associate-Atrial Fibrillation', 'Atrial Fibrillation-associate-Ventricular Dysfunction, Left', 'Neoplasms-predispose-Prostatic Neoplasms', 'Digoxin-treat-Ventricular Dysfunction, Left', 'Digoxin-associate-Atrial Fibrillation', 'Atrial Fibrillation-associate-Digoxin', 'Brain Diseases-show-ODC1', 'NKX3-1-map-Prostatic Neoplasms', 'NKX3-1-predispose-Prostatic Neoplasms', 'Alzheimer Disease-be with-APOE', "Bowen's Disease-include-Skin Neoplasms", "Bowen's Disease-immunostaining-TP53", 'Carcinoma, Squamous Cell-correlated-Neoplasms', 'Carcinoma, Squamous Cell-correlated-TP53', 'Precancerous Conditions-affect-Neoplasms', 'TP53-play-Precancerous Conditions', "Bowen's Disease-demonstrate p53 expression as-Carcinoma, Squamous Cell", "Bowen's Disease-demonstrate-TP53", 'GSTM1-be frequent compare-Neoplasms', 'GSTM1-be in-Neoplasms', 'GSTM1-be frequent in-Neoplasms', 'Heart Failure-implement-ACE', 'ACE-develop-Heart Failure, Diastolic', 'Plaque, Atherosclerotic-correlate In-Hyperlipoproteinemia Type II', 'Hyperlipoproteinemia Type II-correlate-Cholesterol', 'Plaque, Atherosclerotic-correlate with-Cholesterol', 'Infections-seem-Kidney Diseases', 'Infections-increased-Cholestasis', 'Kidney Diseases-increased-Cholestasis', 'Aminoglycosides-seem-Kidney Diseases', 'Neoplasms-deleted-Precursor Cell Lymphoblastic Leukemia-Lymphoma', 'Aminoglycosides-increased-Cholestasis', 'CDKN2A-deleted-Precursor Cell Lymphoblastic Leukemia-Lymphoma', 'Parkinson Disease, Secondary-be due-Death', 'Parkinson Disease, Secondary-be due-NOS2', 'Anemia, Megaloblastic-develop-Nervous System Diseases', 'Coronary Artery Disease-include-Diabetes Mellitus', 'Diabetic Nephropathies-include-Diabetes Mellitus', 'Anemia, Megaloblastic-inverse relationship between-NDUFB3', 'Anemia, Megaloblastic-develop-NDUFB3', 'Diabetes Mellitus-influence-Hypotension', 'Dementia, Vascular-include-Diabetes Mellitus', 'Diabetes Mellitus-influence-ACE', 'ACE-favor-Hypertension', 'ACE-favor-Diabetes Mellitus', 'Coronary Artery Disease-include-ACE', 'Diabetic Nephropathies-include-ACE', 'ACE-include-Dementia, Vascular', 'ACE-decline-Dementia, Vascular', 'Kidney Diseases-include-ACE', 'ACE-decline-Hypertension', 'Death-be in-Melioidosis', 'Drug-Related Side Effects and Adverse Reactions-tested-Lung Neoplasms', 'Etoposide-include-Drug-Related Side Effects and Adverse Reactions', 'Etoposide-tested-Lung Neoplasms', 'EPO-recognized-Anemia', 'EPO-recognized-Kidney Failure, Chronic', 'Hyperglycemia-reduced-Diabetes Mellitus', 'Glucose-reduced-Hyperglycemia', 'Glucose-reduced-Diabetes Mellitus', 'Fat Necrosis-be components of-Metabolic Diseases', 'INS-be components of-Metabolic Diseases', 'Plaque, Amyloid-investigate-Alzheimer Disease', 'NFASC-investigate-Plaque, Amyloid', 'NFASC-investigate-Alzheimer Disease', 'Hypertension-considered-Hypotension', 'Hypertension-considered-ACE', 'Muscular Diseases-taken-Gemfibrozil', 'Rhabdomyolysis-taken-Gemfibrozil', 'Muscular Diseases-taken-Cyclosporine', 'Liver Diseases-prevent-Hepatic Encephalopathy', 'Rhabdomyolysis-taken-Cyclosporine', 'Lactulose-used-Liver Diseases', 'Lactulose-used-Hepatic Encephalopathy', 'Lactulose-prevent-Hepatic Encephalopathy', 'Mucositis-cause-Diarrhea', 'Mucositis-cause-Malabsorption Syndromes', 'Mucositis-occur-Neomycin', 'Diarrhea-occur-Neomycin', 'Malabsorption Syndromes-occur-Neomycin', 'Cardiomyopathies-demonstrated-Drug-Related Side Effects and Adverse Reactions', 'Drug-Related Side Effects and Adverse Reactions-demonstrated-Lung Diseases', 'Cardiovascular Diseases-classified-Diabetes Mellitus', 'Cardiovascular Diseases-classified-Myocardial Infarction', 'Lung Diseases-induced-Bleomycin', 'Cardiovascular Diseases-surveyed-Cholesterol', 'Diabetes Mellitus-excluded-INS', 'Diabetes Mellitus-interfere-INS', 'Kidney Neoplasms-originate-Carcinogenesis', 'Drug-Related Side Effects and Adverse Reactions-evaluated-Lung Neoplasms', 'Etoposide-evaluated-Lung Neoplasms', 'Cholesterol-rise-Coronary Artery Disease', 'Hyperinsulinism-compensate-Glucose Metabolism Disorders', 'Hyperinsulinism-compensate-INS', 'INS-compensate-Glucose Metabolism Disorders', 'INS-be in-Glucose Metabolism Disorders', 'INS-relate-Glucose Metabolism Disorders', 'Hyperinsulinism-relate-INS', 'INS-compensate-Hyperinsulinism', 'Metabolic Diseases-associated-Hypertension', 'Hypertension-associated-Metabolic Diseases', 'Glucose Intolerance-include-Metabolic Diseases', 'Glucose Intolerance-include-Hypertension', 'Dyslipidemias-include-Hypertension', 'Myocardial Infarction-treated-ACE', 'Myocardial Infarction-treated-Enalapril', 'Diabetes Mellitus, Type 2-treated-Enalapril', 'Neoplasms-contribute-Carcinogenesis', 'MAPK1-contribute-Carcinogenesis', 'Inflammation-operate-Neurodegenerative Diseases', 'AGER-consider-Periodontal Diseases', 'AGER-consider-Diabetes Mellitus', 'Pain-consider-Osteomyelitis', 'CRP-consider-Osteomyelitis', 'CYP3A4-associated-Neoplasms', 'Neoplasms-associated-CYP3A4', 'CYP3A4-determine-Prostatic Neoplasms', 'Neoplasms-report-Prostatic Neoplasms', 'CYP3A4-report-Prostatic Neoplasms', 'Capsaicin-be effective analgesic For-Pain', 'Capsaicin-be effective analgesic For-Osteoarthritis', 'Capsaicin-associated-Osteoarthritis', 'Osteoarthritis-associated-Capsaicin', 'Glucose-reduce-Stroke', 'Thrombosis-study-Cardiovascular Diseases', 'Thrombosis-study-TFPI', 'SNCG-be in-Breast Neoplasms', 'SNCG-be in-Neoplasms', 'TFPI-associated-Atherosclerosis', 'Atherosclerosis-associated-TFPI', 'TFPI-associated-Carotid Stenosis', 'Carotid Stenosis-associated-TFPI', 'GSTM1-develop-Neoplasms', 'GSTM1-develop-Urinary Bladder Neoplasms', 'MAPT-distinguish-Alzheimer Disease', 'MAPT-distinguish-Dementia', 'Dementia-start-Alzheimer Disease', 'MAPT-increase-Dementia', 'Pituitary Neoplasms-result-POMC', 'Neoplasms-result-POMC', 'MAPT-start-Alzheimer Disease', 'Brugada Syndrome-associated-Stroke', 'Stroke-associated-Brugada Syndrome', 'Brugada Syndrome-associated-Cerebral Infarction', 'Cerebral Infarction-associated-Brugada Syndrome', 'ACE-associated-Diabetic Nephropathies', 'Diabetic Nephropathies-associated-ACE', 'ACE-associated-Diabetes Mellitus, Type 1', 'Diabetes Mellitus, Type 1-associated-ACE', 'TFPI-precipitate-Disseminated Intravascular Coagulation', 'TFPI-precipitate-Multiple Organ Failure', 'Periodontal Diseases-investigated-Memory Disorders', 'Glycosaminoglycans-investigated-Memory Disorders', 'Glycosaminoglycans-investigated-Periodontal Diseases', 'Glycosaminoglycans-associated-Periodontal Diseases', 'Periodontal Diseases-associated-Glycosaminoglycans', 'Headache-symptoms of-Respiratory Tract Infections', 'Osteoporosis-coupled-Calcinosis', 'Fatty Acids, Essential-develop-Osteoporosis', 'Fatty Acids, Essential-coupled-Calcinosis', 'Calcinosis-associated-Osteoporosis', 'Osteoporosis-associated-Calcinosis', 'Headache Disorders, Secondary-treated-INS', 'Glucosamine-produce-Arthralgia', 'Hyperinsulinism-associated-Metabolic Diseases', 'Metabolic Diseases-associated-Hyperinsulinism', 'Hyperinsulinism-associated-Coronary Artery Disease', 'Coronary Artery Disease-associated-Hyperinsulinism', 'Hyperinsulinism-predispose-Coronary Artery Disease', 'Metabolic Diseases-predispose-Coronary Artery Disease', 'INS-predispose-Coronary Artery Disease', 'IL3-elevated-Stroke', 'Death-related-Euthyroid Sick Syndromes', 'Death-related-ALB', 'Polyploidy-reveal-TP53', 'Aneuploidy-reveal-TP53', 'Myocardial Infarction-include-Cerebrovascular Disorders', 'Hypertension-history of-Myocardial Infarction', 'Gastritis, Atrophic-cause-Malabsorption Syndromes', 'Gastritis, Atrophic-diagnosed-GAST', 'Gastritis, Atrophic-measure-GAST', 'GAST-cause-Malabsorption Syndromes', 'Inflammation-lead-Ulcer', 'Prostaglandins-decrease-Inflammation', 'Coronary Artery Disease-show-Death', 'Gastroenteritis-suffer-Glucose', 'Coronary Artery Disease-associate-Diabetes Mellitus', 'Diabetes Mellitus-associate-Coronary Artery Disease', 'Atherosclerosis-include-Neurodegenerative Diseases', 'Lipid Peroxides-play-Neurodegenerative Diseases', 'Lipid Peroxides-play-Atherosclerosis', 'ACE-improve-Coronary Artery Disease', 'Lipofuscin-have of-Dementia', 'Heart Diseases-include-Death', 'Glucose-include-Death', 'Anemia, Hemolytic-found-PEBP1', 'INS-develop-Hypertension', 'Carcinogenesis-start-Neoplasms', 'Carcinogenesis-start-MT-TG', 'Fructosamine-assessed-Diabetes Mellitus', 'Fructosamine-be in-Diabetes Mellitus', 'GH1-increase-Growth Disorders', 'GH1-be in-Growth Disorders', 'GH1-increase-Obesity', 'Diabetes Mellitus-synergy with-Hypertension', 'GH1-reduced-Hypothyroidism', 'GH1-reduced-Cushing Syndrome', 'Glucose-be equal to-Arteriovenous Malformations', 'Hyperinsulinism-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-Hyperinsulinism', 'Hyperinsulinism-associated-INS', 'INS-associated-Hyperinsulinism', 'CRP-related-Cardiovascular Diseases', 'Death-main cause of be-Cardiovascular Diseases', 'Death-main cause of be-Cholesterol', 'Obesity-reflect-CRP', 'Diabetes Mellitus-reflect-CRP', 'Communicable Diseases-reflect-CRP', 'APOE-examined-Dementia', 'APOE-examined-Intellectual Disability', 'Diabetes Mellitus-be with-Polyneuropathies', 'Cardiovascular Diseases-develop-Heart Failure', 'Prostaglandins-affect-Cardiovascular Diseases', 'Prostaglandins-develop-Heart Failure', 'Ischemia-associated-Infliximab', 'Infliximab-associated-Ischemia', 'TTR-be due-Liver Failure', 'Glucose Intolerance-associated-Obesity', 'Obesity-associated-Glucose Intolerance', 'Glucose Intolerance-confound-Obesity', 'Glucose Intolerance-associated-PTH', 'PTH-associated-Glucose Intolerance', 'PTH-confound-Obesity', 'Hepatitis B-compared-Carcinoma, Hepatocellular', 'Neoplasms-compared-Carcinoma, Hepatocellular', 'Neoplasm Invasiveness-compared-Carcinoma, Hepatocellular', 'Glaucoma-sought-Diabetes Mellitus', 'Fibrosis-compared-Carcinoma, Hepatocellular', 'Stargardt Disease-form of-Macular Degeneration', 'Glaucoma-sought-AKR1B1', 'AKR1B1-sought-Diabetes Mellitus', 'Atherosclerosis-benefit-Cholesterol', 'Heart Diseases-follow-Cholesterol', 'Angina, Unstable-treat-Coronary Artery Disease', 'Angina, Unstable-treat-Myocardial Infarction', 'Angina, Unstable-reflect-Hyperlipidemias', 'Coronary Artery Disease-treat-Myocardial Infarction', 'Coronary Artery Disease-treat-Hyperlipidemias', 'Myocardial Infarction-treat-Hyperlipidemias', 'Angina, Unstable-attain-Cholesterol', 'Coronary Artery Disease-attain-Cholesterol', 'Myocardial Infarction-attain-Cholesterol', 'Cholesterol-attain-Hyperlipidemias', 'ACE-examined-Thrombosis', 'Hyperinsulinism-play-Hypertension', 'INS-play-Hypertension', 'INS-decrease-Hypertension', 'Heart Arrest-facilitate-TP53', 'TP53-facilitate-End Stage Liver Disease', 'Myocardial Infarction-study-Glucose', 'Heart Failure-be with-Glucose', 'Heart Failure-study-Glucose', 'Neurologic Manifestations-be in-Carcinoma, Hepatocellular', 'Neurologic Manifestations-be relevant to-Carcinogenesis', 'Coronary Artery Disease-study-Glucose', 'TP53-be in-Carcinoma, Hepatocellular', 'TP53-be relevant to-Carcinogenesis', 'TGFA-contribute-Cartilage Diseases', 'TGFA-contribute-Osteoarthritis', 'ACE-contribute-Hypertension', 'ACE-contribute-Cardiomegaly', 'Narcolepsy-restore-Atrial Fibrillation', 'Digoxin-prevent-Narcolepsy', 'Digoxin-be ineffective in-Atrial Fibrillation', 'Digoxin-restore-Atrial Fibrillation', 'Heart Diseases-include-ACE', 'Inflammation-related-Angina Pectoris', 'CRP-related-Angina Pectoris', 'Hemorrhage-related-Cerebral Amyloid Angiopathy', 'Hypertriglyceridemia-known-Triglycerides', 'APOE-known-Alzheimer Disease', 'ACE-prescribe-Ventricular Dysfunction, Left', 'ACE-prescribe-Cough', 'ACE-prescribe-Kidney Diseases', 'NPPA-predict-Mitral Valve Insufficiency', 'Aortic Valve Stenosis-be independent predictors of-Death', 'SYP-be uncorrelated Unlike-Alzheimer Disease', 'NPPA-be independent predictors of-Death', 'SYP-be uncorrelated with-Dementia', 'VIM-distinguish-Neoplasms', 'Alzheimer Disease-promote-Dementia', 'CHAT-promote-Alzheimer Disease', 'CHAT-promote-Dementia', 'Hypoglycemia-treated-INS', 'TP53-be in-Stomach Neoplasms', 'Kidney Diseases-lead-Hyponatremia', 'Kidney Diseases-lead-Hyperkalemia', 'Prostaglandins-increased-Kidney Diseases', 'Prostaglandins-lead-Hyponatremia', 'Kidney Diseases-increased-Prostaglandins', 'Prostaglandins-protect-Hyponatremia', 'Prostaglandins-protect-Hyperkalemia', 'Calcifediol-avoid-Osteomalacia', 'Obesity-induce-Hypoglycemia', 'Obesity-induce-Hyperinsulinism', 'Diabetes Mellitus, Type 2-induce-Hypoglycemia', 'Diabetes Mellitus, Type 2-induce-Hyperinsulinism', 'Obesity-induce-INS', 'Diabetes Mellitus, Type 2-induce-INS', 'Aortic Diseases-be in-Alzheimer Disease', 'Aortic Diseases-be in-APOE', 'Aortic Diseases-amyloid-APOE', 'N-Acetylneuraminic Acid-studied-Diabetes Mellitus, Type 1', 'N-Acetylneuraminic Acid-studied-Diabetes Mellitus, Type 2', 'APOE-considered-Alzheimer Disease', 'APOE-considered-Dementia, Vascular', 'N-Acetylneuraminic Acid-increased-Diabetes Mellitus, Type 2', 'N-Acetylneuraminic Acid-studied-Diabetes Mellitus', 'N-Acetylneuraminic Acid-increased-Diabetes Mellitus, Type 1', 'Triglycerides-assessed-Chest Pain', 'Triglycerides-assessed-Coronary Artery Disease', 'Alzheimer Disease-progress-Dementia', 'APOE-progress-Dementia', 'Hypertension-smok increase with-Glucose', 'Sarcoma-used-Histiocytoma, Malignant Fibrous', 'Etoposide-known-Sarcoma', 'Etoposide-used-Histiocytoma, Malignant Fibrous', 'Nervous System Diseases-related-MAPT', 'Dementia-treated-INS', 'INS-treated-Dementia, Vascular', 'INS-treated-Alzheimer Disease', 'Alzheimer Disease-treated-INS', 'Cholesterol-found-Angina Pectoris', 'Cholesterol-found-Myocardial Infarction', 'Cholesterol-found-Thromboembolism', 'Cholesterol-found-Peripheral Vascular Diseases', 'Cholesterol-be In-Coronary Artery Disease', 'Thromboembolism-exacerbate-Dinoprostone', 'Periodontal Diseases-provide-Lipopolysaccharides', 'Acute Kidney Injury-induce-Kidney Tubular Necrosis, Acute', 'Aminoglycosides-produce-Acute Kidney Injury', 'Aminoglycosides-induce-Kidney Tubular Necrosis, Acute', 'CTSD-investigated-Alzheimer Disease', 'CTSD-investigated-Coronary Artery Disease', 'Alzheimer Disease-occur-CTSD', 'CTSD-investigated-Heart Diseases', 'ACE-shown-Hypertension', 'Heart Failure-shown-ACE', 'ACE-reduce-Myocardial Infarction', 'Lisinopril-shown-Hypertension', 'Heart Failure-shown-Lisinopril', 'Lisinopril-reduce-Death', 'Lisinopril-reduce-Myocardial Infarction', 'Glucose Intolerance-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-Glucose Intolerance', 'Alzheimer Disease-hyperphosphorylate-Extranodal Extension', 'Extranodal Extension-hyperphosphorylate-MAPT', 'Kidney Diseases-result-Atherosclerosis', 'Kidney Diseases-result-Cholesterol', 'Glucose Intolerance-show-Weight Loss', 'Glucose Intolerance-show-INS', 'Glucose-measure-Congenital Hyperinsulinism', 'Glucose-measure-Weight Loss', 'Weight Loss-improve-Glucose', 'Plaque, Amyloid-involved-Alzheimer Disease', 'Plaque, Amyloid-involved-Dementia', 'Venlafaxine Hydrochloride-experience-Nausea', 'Venlafaxine Hydrochloride-experience-Sleep Initiation and Maintenance Disorders', 'Venlafaxine Hydrochloride-experience-Disorders of Excessive Somnolence', 'Venlafaxine Hydrochloride-experience-Constipation', 'Glucose-diagnosed-Diabetes Mellitus', 'INS-be higher among-Glucose Intolerance', 'APOE-established-Alzheimer Disease', 'APOE-suggested-Cerebral Amyloid Angiopathy', 'Carcinoma, Hepatocellular-suggest-Carcinogenesis', 'Cardiovascular Diseases-be adverse compare-Glucose', 'Heart Arrest-link-Neoplasms', 'Heart Arrest-link-TP53', 'Shock-activate-HSF1', 'Sleep Initiation and Maintenance Disorders-activate-HSF1', 'Thromboangiitis Obliterans-compare-Atherosclerosis', 'EREG-be in-Thromboangiitis Obliterans', 'EREG-be lower as-Atherosclerosis', 'EREG-compare-Atherosclerosis', 'ELN-investigated-Vasculitis', 'ELN-investigated-Polyarteritis Nodosa', 'ELN-investigated-Arteritis', 'ELN-investigated-Thromboangiitis Obliterans', 'ELN-investigated-Atherosclerosis', 'Insulin Resistance-occur-Glucose Metabolism Disorders', 'Insulin Resistance-occur-Glucose', 'INS-cause-Glucose Intolerance', 'INS-cause-Hypertension', 'INS-cause-Atherosclerosis', 'Drug Hypersensitivity-derive-Hyperinsulinism', 'Hyperinsulinism-related-INS', 'AVP-involved-Taste Disorders', 'Hypothalamic Diseases-lead-Glucose', 'Obesity-be significant-Hypertension', 'Obesity-correlated-Hypertension', 'Hyperglycemia-require-Diabetes Mellitus', 'INS-be significant-Hypertension', 'INS-correlated-Hypertension', 'Atherosclerosis-require-Diabetes Mellitus', 'INS-remain-Obesity', 'Dementia-be in-Alzheimer Disease', 'Blast Injuries-analyzed-Leukemia, Myeloid, Acute', 'Blast Injuries-analyzed-ABCB1', 'ABCB1-be important independent predictors of-Leukemia, Myeloid, Acute', 'Leukemia, Myeloid, Acute-express-Blast Injuries', 'Blast Injuries-express-MR1', 'Hypertrophy, Left Ventricular-compare-Cholesterol', 'Hypertension-compare-Cholesterol', 'Cardiomegaly-compare-Cholesterol', 'VIP-function-Neoplasms', 'VIP-found-Neoplasms', 'VIP-function-Carcinoma, Non-Small-Cell Lung', 'VIP-found-Carcinoma, Non-Small-Cell Lung', 'Death-surgery for-Ischemia', 'Abciximab-reduce-Death', 'Abciximab-reduce-Myocardial Infarction', 'Abciximab-reduce-Takotsubo Cardiomyopathy', 'Abciximab-reduce-Ischemia', 'Death-treated-Abciximab', 'Myocardial Infarction-treated-Abciximab', 'Takotsubo Cardiomyopathy-treated-Abciximab', 'Ischemia-treated-Abciximab', 'Hyperinsulinism-linked-Hypertension', 'INS-linked-Hypertension', 'Neoplasms-occur-Colorectal Neoplasms', 'TP53-occur-Colorectal Neoplasms', 'Glucose Metabolism Disorders-carried-Hypertension', 'Glucose Metabolism Disorders-clarify-INS', 'Glucose Metabolism Disorders-carried-INS', 'INS-carried-Hypertension', 'Liver Cirrhosis-caused-Hypertension', 'Liver Cirrhosis-present-Glutathione', 'Hypertension-present-Glutathione', 'Alzheimer Disease-discriminate-Parkinson Disease', 'Renal Insufficiency-characterized-Metabolic Diseases', 'Renal Insufficiency-described-GH1', 'Kidney Diseases-associated-Arthritis, Rheumatoid', 'Arthritis, Rheumatoid-associated-Kidney Diseases', 'Kidney Diseases-associated-Cyclosporine', 'Cyclosporine-associated-Kidney Diseases', 'Cyclosporine-therapy in-Arthritis, Rheumatoid', 'INS-fasting-Glucose', 'ACE-possess-Heart Failure', 'Cardiac Output, High-fasting-INS', 'ACE-possess-Hypotension, Orthostatic', 'Cardiac Output, High-fasting-Glucose', 'Diabetes Mellitus-be with-Kidney Diseases', 'ACE-considering-Hypertension', 'ACE-improve-Heart Failure', 'ACE-considering-Diabetes Mellitus', 'ACE-considering-Kidney Diseases', 'Atherosclerosis-identified-CETP', 'Weight Loss-improve-Glucose Intolerance', 'Ascorbic Acid-play-Lens Diseases', 'Ascorbic Acid-play-Cataract', 'Diabetes Mellitus-have rate ratio compare-Glucose', 'Adenoma-associated-Cushing Syndrome', 'Cushing Syndrome-associated-Adenoma', 'Blood Platelet Disorders-associated-Hemorrhage', 'Hemorrhage-associated-Blood Platelet Disorders', 'Arachidonic Acid-associated-Hemorrhage', 'Hemorrhage-associated-Arachidonic Acid', 'INS-entail-Hypoglycemia', 'Fatty Acids, Nonesterified-cause-INS', 'INS-cause-Hyperlipidemias', 'Fatty Acids, Nonesterified-cause-Hyperlipidemias', 'Fatty Acids, Nonesterified-cause-Glucose Intolerance', 'Fatty Acids, Nonesterified-cause-Hypertension', 'Fatty Acids, Nonesterified-cause-Atherosclerosis', 'Dwarfism, Pituitary-associated-Muscle Weakness', 'Muscle Weakness-associated-Dwarfism, Pituitary', 'Dwarfism, Pituitary-associated-Muscular Atrophy', 'Muscular Atrophy-associated-Dwarfism, Pituitary', 'Osteoporosis-provide-Bone Neoplasms', 'Osteoporosis-provide-BGLAP', 'Cardiovascular Diseases-found-Constriction, Pathologic', 'Constriction, Pathologic-related-Cholesterol', 'Cholesterol-include-Coronary Artery Disease', 'BCL2-measured-Lupus Erythematosus, Systemic', 'BCL2-measured-Autoimmune Diseases', 'Abnormalities, Drug-Induced-associated-INS', 'INS-associated-Abnormalities, Drug-Induced', 'MAPT-differ-Neurodegenerative Diseases', 'Heart Failure-exist-Inflammation', 'TNF-exist-Heart Failure', 'Alzheimer Disease-characterized-Supranuclear Palsy, Progressive', 'Alzheimer Disease-characterized-Diffuse Neurofibrillary Tangles with Calcification', 'Supranuclear Palsy, Progressive-characterized-Diffuse Neurofibrillary Tangles with Calcification', 'MAPT-composed-Supranuclear Palsy, Progressive', 'MAPT-characterized-Supranuclear Palsy, Progressive', 'Diffuse Neurofibrillary Tangles with Calcification-characterized-MAPT', 'Diffuse Neurofibrillary Tangles with Calcification-composed-MAPT', 'GFAP-measured-Dementia, Vascular', 'GFAP-measured-Alzheimer Disease', 'Weight Gain-associated-Hyperinsulinism', 'Hyperinsulinism-associated-Weight Gain', 'Weight Gain-associated-INS', 'INS-associated-Weight Gain', 'Cholesterol-suggest-Death', 'Coronary Artery Disease-include-Glucose Metabolism Disorders', 'Coronary Artery Disease-associated-Glucose Metabolism Disorders', 'Glucose Metabolism Disorders-associated-Coronary Artery Disease', 'Coronary Artery Disease-associated-Cardiomyopathy, Hypertrophic', 'Cardiomyopathy, Hypertrophic-associated-Coronary Artery Disease', 'Coronary Artery Disease-include-INS', 'AFP-accompany-Liver Cirrhosis', 'Death-reduce-Infarction, Anterior Cerebral Artery', 'Wounds and Injuries-determine-Hyperglycemia', 'Albuminuria-show-Hypertension', 'Albuminuria-show-INS', 'Glucose-conduct-Wounds and Injuries', 'Aneurysm-accelerated-Diabetes Mellitus', 'Diabetes Mellitus-accelerated-Cerebral Small Vessel Diseases', 'Aneurysm-lowering-Glucose', 'Glucose-accelerated-Cerebral Small Vessel Diseases', 'Lisinopril-shown-Death', 'Myocardial Infarction-shown-Lisinopril', 'Hearing Loss-control-Vertigo', 'Hearing Loss-prove-Gentamicins', 'Gentamicins-control-Vertigo', 'Diabetes Mellitus, Type 2-undergo-Glucose Metabolism Disorders', 'Atrial Fibrillation-predict-Stroke', 'Hypertension-predict-Stroke', 'Diabetes Mellitus, Type 2-predict-Stroke', 'INS-predict-Stroke', 'Prostatic Diseases-exhibit-KLK3', 'KLK3-show-Prostatic Hyperplasia', 'Diabetes Mellitus-predict-Stroke', 'RNASE3-measured-Dermatitis, Atopic', 'Arthritis, Rheumatoid-fail-Anemia', 'Arthritis, Rheumatoid-fail-EPO', 'Arthritis, Rheumatoid-caused-EPO', 'Anemia-caused-EPO', 'Death-significant predictors of be-Heart Failure', 'Diabetes Mellitus-show-Glucose', 'Cholesterol-retain-Coronary Artery Disease', 'NPY-increase-Hypertension', 'NPY-increase-Pheochromocytoma', 'Diabetes Mellitus-associated-Werner Syndrome', 'Werner Syndrome-associated-Diabetes Mellitus', 'INS-involved-Diabetes Mellitus', 'INS-associated-Werner Syndrome', 'Werner Syndrome-associated-INS', 'Pain-improve-Osteoarthritis', 'Glucosamine-decrease-Pain', 'Glucosamine-improve mobility in-Osteoarthritis', 'LTF-associated-Alzheimer Disease', 'Alzheimer Disease-associated-LTF', 'LTF-associated-Pick Disease of the Brain', 'Pick Disease of the Brain-associated-LTF', 'Neurodegenerative Diseases-reversed-Dolichols', 'Alzheimer Disease-reversed-Dolichols', 'EREG-be diminish in-Colorectal Neoplasms', 'EREG-introduction in-Colonic Neoplasms', 'Diabetes Mellitus-be unrelated to-Calcinosis', 'INS-be unrelated to-Calcinosis', 'Glycosaminoglycans-detected-Neoplasms', 'NGF-related-Atrophy', 'NGF-treat-Alzheimer Disease', 'NGF-used-Alzheimer Disease', 'Prostatic Neoplasms-develop-Neoplasms', 'Cholesterol-caused-Chronic Disease', 'ALB-include-Coronary Artery Disease', 'Kidney Failure, Chronic-revolutionise-Anemia', 'EPO-have revolutionise-Anemia', 'EPO-have revolutionise-Kidney Failure, Chronic', 'EPO-associated-Kidney Failure, Chronic', 'Kidney Failure, Chronic-associated-EPO', 'EPO-revolutionise-Anemia', 'Lip Diseases-reacted-CD1A', 'Hypokalemia-detect-Liver Diseases', 'Hantavirus Pulmonary Syndrome-reacted-CD1A', 'Mouth Diseases-reacted-CD1A', 'Hypokalemia-detect-Digoxin', 'Epoprostenol-participate-Erectile Dysfunction', 'Epoprostenol-participate-Priapism', 'Coronary Artery Disease-reduce-Death', 'Diabetes Mellitus, Type 2-show-Chemical and Drug Induced Liver Injury', 'Pancreatic Neoplasms-present as-Pancreatitis', 'Pancreatic Neoplasms-present-Octreotide', 'Glucose Metabolism Disorders-studied-Myotonic Dystrophy', 'Glucose-studied-Myotonic Dystrophy', 'APOE-bind-Plaque, Amyloid', 'APOE-bind-Alzheimer Disease', 'TTR-present-Pain', 'TTR-present-Arrhythmias, Cardiac', 'Heart Diseases-be prominent clinical feature Like-Polyneuropathies', 'Heart Diseases-be prominent clinical feature of-Amyloidosis, Familial', 'Glucose Metabolism Disorders-use-INS', 'Heart Diseases-be prominent clinical feature of-TTR', 'Ventricular Dysfunction-benefit-AP2B1', 'Myocardial Infarction-benefit-AP2B1', 'Dehydration-induced-AVP', 'AVP-reduce-Waterborne Diseases', 'Congenital Hyperinsulinism-be with-Glucose', 'Coronary Artery Disease-be related to-Cholesterol', 'Death-be related to-Cholesterol', 'Hyperinsulinism-increase-INS', 'INS-increase-Glucose Intolerance', 'Ascorbic Acid-associated-Cholesterol', 'Cholesterol-associated-Ascorbic Acid', 'Ascorbic Acid-effect-Cholesterol', 'Ascorbic Acid-associated-Gallstones', 'Gallstones-associated-Ascorbic Acid', 'Ascorbic Acid-effect-Gallstones', 'Ascorbic Acid-play-Gallbladder Diseases', 'INS-characterized-Diabetes Mellitus, Type 2', 'INS-required-Infections', 'Infliximab-preserved-Alzheimer Disease', 'Infliximab-preserved-Parkinson Disease', 'Hypoglycemia-be serious risk for-Diabetes Mellitus', 'Hypoglycemia-be serious risk for-INS', 'Cholesterol-result-Coronary Artery Disease', 'Cholesterol-estimated-Coronary Artery Disease', 'Cholesterol-result-Death', 'Cholesterol-estimated-Death', 'Fetal Diseases-increase-Valproic Acid', 'Weight Loss-be in-Obesity', 'GH1-promote-Weight Loss', 'GH1-promote-Obesity', 'Nerve Degeneration-lead-Hyperinsulinism', 'Glucose-impair-Nerve Degeneration', 'Glucose-lead-Hyperinsulinism', 'Hyperinsulinism-lead-Hypoglycemia', 'Hyperinsulinism-follow-Hyperglycemia', 'Hyperinsulinism-induce-Hyperglycemia', 'Triglycerides-associated-Glucose Intolerance', 'Glucose Intolerance-associated-Triglycerides', 'Hypoglycemia-follow-Hyperglycemia', 'Hypoglycemia-induce-Hyperglycemia', 'Hyperinsulinism-follow-INS', 'INS-follow-Hypoglycemia', 'INS-lead-Hypoglycemia', 'Hyperglycemia-follow-INS', 'ACE-prevent-Ventricular Fibrillation', 'Alzheimer Disease-increase-Plaque, Amyloid', 'Alzheimer Disease-increase-MAP2', 'Plaque, Amyloid-increase-MAP2', 'Lipid Peroxides-include-Neoplasms', 'Lipid Peroxides-include-Multiple Sclerosis', 'Lipid Peroxides-include-Parkinson Disease', 'Lipid Peroxides-include-Autoimmune Diseases', 'Lipid Peroxides-include-Ischemia', 'Ovarian Diseases-associated-Hyperinsulinism', 'Hyperinsulinism-associated-Ovarian Diseases', 'Lipid Peroxides-include-Anemia', 'Ovarian Diseases-associated-INS', 'INS-associated-Ovarian Diseases', 'Lipid Peroxides-include-Alzheimer Disease', 'Lipid Peroxides-include-Asbestosis', 'Neoplasms-be in-Brain Neoplasms', 'Lipid Peroxides-include-Thalassemia', 'TP53-be in-Brain Neoplasms', 'EPO-increase-Anemia, Iron-Deficiency', 'Hypothalamic Diseases-direct-MAPT', 'Alzheimer Disease-recognize-MAPT', 'MAPT-recognize-Alzheimer Disease', 'MAPT-recognize-Hypothalamic Neoplasms', 'Osteoporotic Fractures-treatment with-Calcitriol', 'TNF-measured-Sarcoidosis', 'TNF-measured-Pulmonary Fibrosis', 'Glucose Intolerance-study-Glucose', 'Malnutrition-reduce-Coronary Artery Disease', 'Cholesterol-result-Malnutrition', 'G(M1) Ganglioside-be in-Acute Disease', 'Infections-expressed-Hematuria', 'Hypertension-show-Cholesterol', 'G(M1) Ganglioside-encouraged-Stroke', 'G(M1) Ganglioside-encouraged-Subarachnoid Hemorrhage', 'G(M1) Ganglioside-encouraged-Spinal Cord Injuries', 'Carotid Artery Diseases-compare-Constriction, Pathologic', 'INS-studied-Congenital Hyperinsulinism', 'INS-studied-Obesity', 'Hypertension-accompanied-Heart Failure', 'Heart Failure-accompanied-Angina Pectoris', 'N-Acetylneuraminic Acid-measured-Thrombocytopenia', 'Heart Failure-accompanied-Hypertension', 'N-Acetylneuraminic Acid-measured-Purpura, Thrombocytopenic', 'N-Acetylneuraminic Acid-obtained-Purpura, Thrombocytopenic', 'ACE-accompanied-Heart Failure', 'ACE-blunt-Hypokalemia', 'ACE-blunt-Hypercholesterolemia', 'ACE-blunt-Hyperuricemia', 'Glomerulosclerosis, Focal Segmental-be with-Hypertension', 'ACE-blunt-Hyperglycemia', 'Glomerulosclerosis, Focal Segmental-evaluated-Glucose Metabolism Disorders', 'INS-found-Glomerulosclerosis, Focal Segmental', 'Hypertension-associated-Glucose Metabolism Disorders', 'Glucose Metabolism Disorders-associated-Hypertension', 'INS-found-Hypertension', 'Glomerulosclerosis, Focal Segmental-evaluated-INS', 'Hypertension-evaluated-INS', 'Glomerulosclerosis, Focal Segmental-evaluated-Glucose', 'Hypertension-evaluated-Glucose', 'Glucose Metabolism Disorders-associated-Glucose', 'Glucose-associated-Glucose Metabolism Disorders', 'Hypertension-characterized-Chemical and Drug Induced Liver Injury', 'Hypertension-characterized-INS', 'Hypertension-characterized-Glucose', 'Neoplasms-implicated-Xerostomia', 'Autoimmune Diseases-implicated-Xerostomia', 'Diabetes Mellitus-implicated-Xerostomia', 'Hypertension-implicated-Xerostomia', 'Cholesterol-be higher in-Peripheral Arterial Disease', 'Muscle Rigidity-increased-Hypertension', 'Hypertension-be with-Cholesterol', 'Muscle Rigidity-increased-Cholesterol', 'LINC02605-open-Intracranial Hemorrhage, Hypertensive', 'LINC02605-open-Hematoma', 'Asphyxia-stained-GFAP', 'Respiratory Tract Infections-stained-GFAP', 'LINC02605-indicated-Hematoma', 'Fatty Acids-depleted-Glycogen', 'Glycogen-depleted-Fatty Acids', 'Glycogen-involved-Fatigue', 'Glycogen-occur-Fatigue', 'Fatty Acids-involved-Fatigue', 'KLK3-distinguish-Prostatic Neoplasms', 'KLK3-distinguish-Prostatic Hyperplasia', 'Hypertension-continue-Coronary Artery Disease', 'Diabetes Mellitus-continue-Coronary Artery Disease', 'Alzheimer Disease-studied-MAPT', 'Dementia-studied-MAPT', 'REN-studied-Hypertension, Renovascular', 'REN-studied-Hypertension', 'Werner Syndrome-associated-Glucose Metabolism Disorders', 'Glucose Metabolism Disorders-associated-Werner Syndrome', 'INS-be due-Glucose Metabolism Disorders', 'Obesity-reduce-Cholesterol', 'Diabetes Mellitus, Type 2-reduce-Cholesterol', 'Hypertension-reduce-Cholesterol', 'Hyperlipidemias-reduce-Cholesterol', 'Liver Cirrhosis-combination of-Pneumonia', 'Werner Syndrome-associated-Glucose Intolerance', 'Glucose Intolerance-associated-Werner Syndrome', 'Genetic Diseases, Inborn-associated-Glucose Intolerance', 'Glucose Intolerance-associated-Genetic Diseases, Inborn', 'Hypertension-lead-Arrhythmias, Cardiac', 'Heart Diseases-lead-Arrhythmias, Cardiac', 'Liver Diseases-lead-Arrhythmias, Cardiac', 'Hypertension-lead-Glucose', 'Heart Diseases-lead-Glucose', 'Liver Diseases-lead-Glucose', 'Atrial Fibrillation-be resistant to-Glycosides', 'Heart Failure-be resistant to-Glycosides', 'Diabetes Mellitus-treated-Ascorbic Acid', 'Arthritis-treated-Ascorbic Acid', 'Aneurysm-treated-Ascorbic Acid', 'Hypertension-treated-Ascorbic Acid', 'Cholesterol-cause-Plaque, Atherosclerotic', 'Cholesterol-lead-Plaque, Atherosclerotic', 'Cholesterol-lead-Hypotension', 'Cholesterol-used-Coronary Artery Disease', 'Cholesterol-used-Death', 'Small Cell Lung Carcinoma-constitute-Drug-Related Side Effects and Adverse Reactions', 'Etoposide-constitute-Small Cell Lung Carcinoma', 'Etoposide-constitute-Drug-Related Side Effects and Adverse Reactions', 'Coronary Artery Disease-lead cause of-Death', 'Inflammation-controlled-Crohn Disease', 'Inflammation-controlled-Inflammatory Bowel Diseases', 'Inflammation-controlled-Cyclosporine', 'INS-underlie-Dysgeusia', 'Hypertension-include-Stroke', 'Diabetes Mellitus-include-Stroke', 'Cholesterol-include-Stroke', 'Alzheimer Disease-occur-Nerve Degeneration', 'Gangliosides-occur-Nerve Degeneration', 'Hyperlipidemias-use-Coronary Artery Disease', 'Death-arise-Drug Overdose', 'Cholesterol-screen-Hyperlipidemias', 'Cholesterol-use-Coronary Artery Disease', 'Obesity-avoid-Neoplasms', 'Obesity-avoid-Cardiovascular Diseases', 'Obesity-avoid-Stroke', 'Dietary Fiber-avoid-Obesity', 'Duodenal Ulcer-shown-Misoprostol', 'Dietary Fiber-reduce-Neoplasms', 'Death-investigated-Hypertension', 'Weight Loss-evaluated-REN', 'Cholesterol-investigated-Hypertension', 'Weight Loss-evaluated-Fatty Acids, Nonesterified', 'Cardiovascular Diseases-be major cause-Death', 'Cardiovascular Diseases-be major cause of-Death', 'Cardiovascular Diseases-considered-Cholesterol', 'Death-considered-Cholesterol', 'Cardiovascular Diseases-height-Drug-Related Side Effects and Adverse Reactions', 'Cardiovascular Diseases-height-Digoxin', 'Renal Insufficiency, Chronic-induce-Hyperparathyroidism, Secondary', 'Hyperphosphatemia-induce-Hyperparathyroidism, Secondary', 'Ulcer-prevent-Stomach Ulcer', 'Hypocalcemia-induce-Hyperparathyroidism, Secondary', 'Ulcer-used-Misoprostol', 'Misoprostol-prevent-Stomach Ulcer', 'Misoprostol-used-Stomach Ulcer', 'Calcitriol-induce-Hyperparathyroidism, Secondary', 'INS-involved-Hypertension', 'Hyperinsulinism-exist-Hypertension', 'INS-exist-Hypertension', 'Hyperinsulinism-lead-Hypertension', 'Macular Degeneration-treat-Peripheral Nervous System Diseases', 'Diabetes Mellitus-treat-Peripheral Nervous System Diseases', 'Macular Degeneration-use-INS', 'INS-use-Peripheral Nervous System Diseases', 'INS-treat-Peripheral Nervous System Diseases', 'Weight Loss-induced-Diabetes Mellitus', 'Weight Gain-caused-Hypoglycemia', 'INS-used-Ketosis', 'Glucose-caused-Weight Gain', 'Glucose-caused-Hypoglycemia', 'INS-used-Weight Loss', 'INS-used-Obesity', 'INS-used-Headache Disorders, Secondary', 'INS-Established adverse effects of be-Hypoglycemia', 'Diabetes Mellitus, Type 2-therapy for-Diabetes Mellitus, Type 1', 'INS-involve-Diabetes Mellitus, Type 2', 'INS-involve-Diabetes Mellitus, Type 1', 'IL2-used-Neoplasms', 'IL2-used-Acquired Immunodeficiency Syndrome', 'ACE-reduce-Hypertension', 'Hypoglycemia-identified-Hyperglycemia', 'Hypoglycemia-drifting-Glucose', 'Glucose-drifting-Hyperglycemia', 'Glucose-identified-Hyperglycemia', 'Hyperlipidemias-make-Blood Glucose', 'Obesity-make-Blood Glucose', 'Hypertension-make-Blood Glucose', 'ACE-include-Headache', 'Fatigue-include-ACE', 'Hyperglycemia-associated-Ketosis', 'Ketosis-associated-Hyperglycemia', 'ACE-include-Cough', 'Hyperglycemia-associated-Hyperlipidemias', 'Hyperlipidemias-associated-Hyperglycemia', 'ACE-include-Exanthema', 'ACE-include-Hypotension', 'Diarrhea-include-ACE', 'Hypoglycemia-risk of-Cardiovascular Diseases', 'Hypoglycemia-include-Cardiovascular Diseases', 'Femoral Neck Fractures-reduced-Osteomalacia', 'INS-include-Hyperinsulinism', 'Dihydroxycholecalciferols-reduced-Femoral Neck Fractures', 'Dihydroxycholecalciferols-reduced-Osteomalacia', 'GFAP-compare-Alzheimer Disease', 'INS-started-Diabetes Mellitus', 'INS-started-Ketosis', 'INS-started-Weight Loss', 'Neoplasms-expected-ALB', 'Respiratory Insufficiency-exhibit-Seizures', 'Sucralfate-prevent-Mucositis', 'Aminophylline-take-Respiratory Insufficiency', 'Misoprostol-prevent-Mucositis', 'Aminophylline-exhibit-Seizures', 'Arrhythmias, Cardiac-include-Cardiotoxicity', 'Heart Block-include-Cardiotoxicity', 'Drug Resistant Epilepsy-include-Cardiotoxicity', 'Digoxin-cause-Cardiotoxicity', 'Digoxin-cause-Arrhythmias, Cardiac', 'Digoxin-cause-Heart Block', 'Digoxin-cause-Drug Resistant Epilepsy', 'Drug-Related Side Effects and Adverse Reactions-develop-Heart Failure', 'FANCB-indicated-Digoxin', 'FANCB-indicated-Drug-Related Side Effects and Adverse Reactions', 'FANCB-develop-Heart Failure', 'Digoxin-develop-Heart Failure', 'Hypoglycemia-be underappreciated and fatal complication of-INS', 'Diabetes Mellitus-lose-Hypoglycemia', 'Hypoglycemia-lose-Pregnancy, Prolonged', 'Diabetes Mellitus-lose-GCG', 'GCG-lose-Pregnancy, Prolonged', 'Cholesterol-include-Aneurysm', 'Obesity-associated-Hyperinsulinism', 'Hyperinsulinism-associated-Obesity', 'Obesity-decrease-Cholesterol', 'Hyperinsulinism-result-Cholesterol', 'Hyperinsulinism-decrease-Cholesterol', 'Cholesterol-be major component in-Atherosclerosis', 'Pentoses-relate-Hemolysis', 'Muscle Rigidity-seen-Hypertension', 'ELN-reduce-Muscle Rigidity', 'Drug-Related Side Effects and Adverse Reactions-exemplified-Ulcer', 'Drug-Related Side Effects and Adverse Reactions-exemplified-Valproic Acid', 'Muscular Diseases-presented-Dermatomyositis', 'Lambert-Eaton Myasthenic Syndrome-presented-Dermatomyositis', 'Immunologic Deficiency Syndromes-evaluate-Phalloidine', 'Neurologic Manifestations-studied-Stroke', 'Glucose-studied-Stroke', 'Glycolipids-cause-Protein S Deficiency', 'Leukemia, Myeloid, Acute-carry-Death', 'Leukemia, Myeloid, Acute-provide-Aneuploidy', 'Leukemia, Myeloid, Acute-provide-Blast Injuries', 'TRH-administered-Memory Disorders', 'TRH-administered-Dementia', 'Peptic Ulcer-reduce-Misoprostol', 'CRP-studied-Infections', 'CRP-increased-Infections', 'CRP-increased-Inflammation', 'CD4-associated-Bone Resorption', 'Bone Resorption-associated-CD4', 'Venous Thrombosis-supplemented-Heparin', 'Pulmonary Embolism-supplemented-Heparin', 'Infarction-include-Heparin', 'Heart Failure-include-Heparin', 'Thromboembolism-include-Heparin', 'GIP-blunted-Obesity', 'GIP-blunted-Glucose Intolerance', 'GIP-involved-Hyperinsulinism', 'GIP-involved-Diabetes Mellitus, Type 2', 'Kidney Failure, Chronic-seen-Hemostatic Disorders', 'Hypothyroidism-seen-Hemostatic Disorders', 'MAPT-detect-Plaque, Amyloid', 'Hemostatic Disorders-be major factors in-Kidney Failure, Chronic', 'Myocardial Infarction-show-Hypothalamic Neoplasms', 'Myocardial Infarction-show-POMC', 'Hypertension-treat-Heart Failure', 'Neoplasms-investigated-Sarcoma', 'IL2-investigated-Sarcoma', 'IL2-bear-Sarcoma', 'Neoplasms-represent-Histiocytoma, Malignant Fibrous', 'Rhabdomyosarcoma-represent-Histiocytoma, Malignant Fibrous', 'Sarcoma-represent-Histiocytoma, Malignant Fibrous', 'GLUD1-decreased-Olivopontocerebellar Atrophies', 'Glomerulonephritis-induced-Diabetes Mellitus', 'GLUD1-decreased-Parkinson Disease', 'Glomerulonephritis-induced-Nephrosis', 'GLUD1-decreased-Alzheimer Disease', 'Glomerulonephritis-induced-Puromycin Aminonucleoside', 'GLUD1-be lower in-Olivopontocerebellar Atrophies', 'ELN-reduced-Aneurysm', 'ELN-reduced-Atherosclerosis', 'Obesity-present-Hyperglycemia', 'Diabetes Mellitus, Type 2-present-Hyperglycemia', 'Obesity-placed-INS', 'Obesity-preserve-INS', 'Obesity-treated-INS', 'Diabetes Mellitus, Type 2-treated-INS', 'Diabetes Mellitus, Type 2-placed-INS', 'Diabetes Mellitus, Type 2-preserve-INS', 'Hyperglycemia-placed-INS', 'Hyperglycemia-preserve-INS', 'Pain-compared-Angina Pectoris', 'Pain-compared-Angina, Stable', 'Isosorbide Dinitrate-compared-Angina Pectoris', 'Isosorbide Dinitrate-compared-Angina, Stable', 'Cholesterol-show-Atherosclerosis', 'Malabsorption Syndromes-caused-Blind Loop Syndrome', 'Acromegaly-include-Hypertension', 'INS-occur-Hypertension', 'INS-include-Acromegaly', 'INS-occur-Essential Hypertension', 'Diabetes Mellitus-sustained-Hypertension', 'Diabetes Mellitus-be state of-INS', 'INS-sustained-Hypertension', 'Diabetes Mellitus-show-INS', 'Hypertension-suggest-INS', 'Hypertension-show-INS', 'Diabetes Mellitus, Type 2-characterized-Hyperinsulinism', 'Glucose-show-Diabetes Mellitus', 'Hypertension-combined-Diabetes Mellitus', 'Hypertension-characterized-Hyperinsulinism', 'Diabetes Mellitus-appear-Hyperinsulinism', 'Diabetes Mellitus-appear-INS', 'Hypokalemia-exacerbate-Arrhythmias, Cardiac', 'Hypokalemia-associated-Digoxin', 'Digoxin-associated-Hypokalemia', 'Alzheimer Disease-identify-Plaque, Amyloid', 'Alzheimer Disease-reacted-GFAP', 'GFAP-identify-Plaque, Amyloid', 'Chronic Disease-seem-Hypoglycemia', 'Liver Failure-predispose factors in-Hypoglycemia', 'Liver Failure-seem-Hypoglycemia', 'Heart Diseases-be in-Hyperlipoproteinemia Type II', 'Heart Diseases-be in-Cholesterol', 'Chronic Disease-decrease-Glucose', 'Liver Failure-decrease-Glucose', 'ACE-presented-Hypertension', 'ACE-presented-Heart Failure', 'ACE-presented-Renal Insufficiency', 'Cardiovascular Diseases-modify-Plaque, Atherosclerotic', 'Cardiovascular Diseases-inhibit-Cholesterol', 'Plaque, Atherosclerotic-modify-Cholesterol', 'Diabetes Mellitus-impaired-Calcinosis', 'Atherosclerosis-affect-Glucose', 'Hypertension-affect-Glucose', 'Obesity-affect-Glucose', 'IAPP-linked-Diabetes Mellitus', 'IAPP-linked-Diabetes Mellitus, Type 2', 'IAPP-purified-Insulinoma', 'Cataract-derived-Diabetes Mellitus', 'Spinal Fractures-be with-Hip Fractures', 'Heart Failure-reduce-Death', 'Heart Failure-reduce-Isosorbide Dinitrate', 'Isosorbide Dinitrate-reduce-Death', 'Streptozocin-associated-Hyperglycemia', 'Hyperglycemia-associated-Streptozocin', 'Cataract-show-Glucose Metabolism Disorders', 'Diabetes Mellitus-show-Glucose Metabolism Disorders', 'Enalapril-reduce In-Heart Failure', 'Glycosaminoglycans-compared-Alzheimer Disease', 'Sorbitol-show-Glucose Metabolism Disorders', 'Glycosaminoglycans-compared-Dementia, Vascular', 'Alzheimer Disease-involved-Anorexia', 'Alzheimer Disease-involved-NPY', 'NPY-involved-Anorexia', 'Multiple Sclerosis-normalized-Neuronal Ceroid-Lipofuscinoses', 'Multiple Sclerosis-show-Heredodegenerative Disorders, Nervous System', 'Multiple Sclerosis-characterized-Vision Disorders', 'Multiple Sclerosis-characterized-Epilepsy', 'Multiple Sclerosis-characterized-Dementia', 'Neuronal Ceroid-Lipofuscinoses-show-Heredodegenerative Disorders, Nervous System', 'Heredodegenerative Disorders, Nervous System-characterized-Vision Disorders', 'Heredodegenerative Disorders, Nervous System-characterized-Epilepsy', 'Heredodegenerative Disorders, Nervous System-characterized-Dementia', 'POMC-reduced-Ataxia Telangiectasia', 'Hypogonadism-influence-Metabolic Diseases', 'Coronary Artery Disease-include-Hypertriglyceridemia', 'Hypogonadism-involve-CALCA', 'Coronary Artery Disease-include-Hyperuricemia', 'Metabolic Diseases-involve-CALCA', 'Coronary Artery Disease-include-Obesity', 'Coronary Artery Disease-include-Glucose', 'Gonadal Disorders-regulate-CALCA', 'Glucosephosphate Dehydrogenase Deficiency-involved-Osteoporosis', 'Wounds and Injuries-require-Femoral Fractures', 'Cholecalciferol-require-Wounds and Injuries', 'Fatty Acids-analyzed-Alzheimer Disease', 'Cholecalciferol-require-Femoral Fractures', 'Fatty Acids-analyzed-Dementia, Vascular', 'Hypothyroidism-diagnosed-TRH', 'Hypertension, Renovascular-be with-Hypertension', 'Glycosaminoglycans-measured-Renal Insufficiency', 'Glycosaminoglycans-measured-Kidney Failure, Chronic', 'Proteinuria-show-Nephrotic Syndrome', 'Hypertension, Renovascular-show-Nephrotic Syndrome', 'REN-show-Nephrotic Syndrome', 'Infections-fall-Neoplasms', 'CRP-reveal-Infections', 'CRP-localize-Neoplasms', 'Lens Diseases-contribute-Cataract', 'Lens Diseases-contribute-Ascorbic Acid', 'Cataract-contribute-Ascorbic Acid', 'Arrhythmias, Cardiac-diminish-Heart Failure', 'ACE-diminish-Arrhythmias, Cardiac', 'ACE-diminish-Heart Failure', 'Atrial Fibrillation-found-Hyperthyroidism', 'Atrial Fibrillation-found-Hypothyroidism', 'Atrial Fibrillation-found-TRH', 'Anemia-corrected-Malabsorption Syndromes', 'Anemia-corrected-Xylose', 'Thyroid Diseases-considered-Hypothyroidism', 'Atrial Fibrillation-considered-Hypothyroidism', 'TRH-detect-Thyroid Diseases', 'TRH-detect-Atrial Fibrillation', 'TRH-considered-Hypothyroidism', 'Anemia-suggest-Stomach Neoplasms', 'Stomach Neoplasms-combined-Malabsorption Syndromes', 'Stomach Neoplasms-suggest-Malabsorption Syndromes', 'Blind Loop Syndrome-suggest-Stomach Neoplasms', 'Stomach Neoplasms-combined-NDUFB3', 'Stomach Neoplasms-suggest-NDUFB3', 'Alzheimer Disease-result-Nerve Degeneration', 'MAPT-result-Nerve Degeneration', 'Carpal Tunnel Syndrome-studied-Diabetes Mellitus, Type 2', 'Marfan Syndrome-include-Aneurysm', 'Dilatation, Pathologic-contain-ELN', 'Marfan Syndrome-contain-ELN', 'Vision Disorders-be in-Alzheimer Disease', 'CAT-be in-Alzheimer Disease', 'Glucose Intolerance-decline-Insulin Resistance', 'Glucose Intolerance-decline-INS', 'Glucose Intolerance-decrease-Diabetes Mellitus, Type 2', 'INS-decline-Insulin Resistance', 'Glucose Intolerance-decrease-INS', 'Hypokalemia-induced-Digoxin', 'Cyclosporine-seem-Cold Injury', 'Cyclosporine-seem-Ischemia', 'Cholesterol-estimated-Intellectual Disability', 'Cholesterol-be in-Intellectual Disability', 'Infections-treated-Drug-Related Side Effects and Adverse Reactions', 'Infections-treated-Aminoglycosides', 'Streptomycin-increase-Hearing Disorders', 'Memory Disorders-precede-Alzheimer Disease', 'Werner Syndrome-exhibit-Glutathione', 'Memory Disorders-precede-Glucose', 'Neuronal Ceroid-Lipofuscinoses-exhibit-Glutathione', 'Hypertension-receive-Enalapril', 'Heart Failure-receive-Enalapril', 'Neoplasms-obtained-TMED2', 'ELN-laid-Facial Dermatoses', 'Glucose Metabolism Disorders-be in-Werner Syndrome', 'Glucose-reveal-Glucose Metabolism Disorders', 'Glucose-reveal-Werner Syndrome', 'Glucose-be in-Werner Syndrome', 'Osteomalacia-found-Immunologic Deficiency Syndromes', 'Osteomalacia-found-Calcifediol', 'Cystic Fibrosis-expose-Sugars', 'CEACAM3-found-Kidney Failure, Chronic', 'CEACAM3-found-Neoplasms', 'Death-reflect-Coronary Artery Disease', 'Death-reflect-Cholesterol', 'Cholesterol-retain-Death', 'Kidney Diseases-become-Aneurysm', 'Kidney Diseases-become-REN', 'REN-become-Aneurysm', 'Alzheimer Disease-correlate-Dementia', 'Alprostadil-raised-Alzheimer Disease', 'Alprostadil-raised-Dementia', 'Alprostadil-correlate-Dementia', 'Hypertension-characterized-Cardiomyopathy, Hypertrophic', 'Hypertension-characterized-REN', 'Hypertrophy-include-Lichen Planus', 'Muscular Disorders, Atrophic-include-Lichen Planus', 'Lichen Planus-examined-ABO', 'Hypertrophy-examined-ABO', 'Muscular Disorders, Atrophic-examined-ABO', 'Death-reflect-Aminoglycosides', 'Meningitis-reflect-Aminoglycosides', 'Diabetes Mellitus-be with-Acidosis', 'Cholesterol-be cause of-Atherosclerosis', 'Hypertension-correlated-Stroke', 'Hypertension-correlated-Myocardial Infarction', 'Werner Syndrome-protect-Drug-Related Side Effects and Adverse Reactions', 'Werner Syndrome-determine-CAT', 'Hypertension-correlated-Sugars', 'Drug-Related Side Effects and Adverse Reactions-protect-CAT', 'Drug-Related Side Effects and Adverse Reactions-protect-Glutathione', 'Hypertension-correlated-Cholesterol', 'Hearing Loss-produce-Tuberculosis', 'Hearing Loss-produce-Infections', 'Neoplasms-show-Malnutrition', 'INS-carried-Diabetes Mellitus, Type 2', 'INS-carried-Diabetes Mellitus', 'Hearing Loss-produce-Aminoglycosides', 'Chemical and Drug Induced Liver Injury-be with-Glucose', 'ALB-show correlation In-Neoplasms', 'Drug-Related Side Effects and Adverse Reactions-compare-Heart Failure', 'Aminoglycosides-receive-Tuberculosis', 'ALB-show-Neoplasms', 'Digoxin-compare-Heart Failure', 'Aminoglycosides-receive-Infections', 'Hypotension-reduce-Hypertension', 'Hypotension-used-Hypertension', 'Hypotension-produce-Hypotension, Orthostatic', 'Hypotension-produce-Bradycardia', 'Hypertension-produce-Hypotension, Orthostatic', 'Hypertension-produce-Bradycardia', 'Hypotension-produce-Glucose', 'Hypertension-produce-Glucose', 'Kidney Papillary Necrosis-be consequence of-Drug-Related Side Effects and Adverse Reactions', 'Kidney Papillary Necrosis-result-Ischemia', 'Cholesterol-lowering-Death', 'TRH-orchidectomised-Prostatic Neoplasms', 'Cholesterol-reduce-Cardiomyopathies', 'Endocrine System Diseases-show-GNRH1', 'Adenoma-constitute-Pituitary Neoplasms', 'Adenoma-reveal-PRL', 'Digoxin-receive-Death', 'Parkinsonian Disorders-be with-Dementia', 'Parkinsonian Disorders-regimen of-Lecithins', 'Digoxin-determined-Myocardial Stunning', 'Digoxin-receive-Myocardial Stunning', 'Endometrial Neoplasms-reflect-Neoplasms', 'Neoplasms-reflect-PGM1', 'Endometrial Neoplasms-reflect-PGM1', 'Cholesterol-related-Atherosclerosis', 'Sucrose-reveal-Neoplasms', 'Sucrose-reveal-Nephritis', 'Anemia-seen-End Stage Liver Disease', 'Adenoma, Villous-be with-Neoplasms', 'Huntington Disease-reveal-Nerve Degeneration', 'CEACAM3-noted-Adenoma, Villous', 'CEACAM3-noted-Neoplasms', 'Huntington Disease-reveal-Lipofuscin', 'Lipofuscin-measured-Heredodegenerative Disorders, Nervous System', 'Lipofuscin-measured-Death', 'ELN-demonstrated-Diabetes Mellitus', 'Neoplasms-occur-Communicable Diseases', 'CALCA-level of be-Neoplasms', 'CEACAM3-measured-Colorectal Neoplasms', 'CEACAM3-measured-Colonic Polyps', 'CEACAM3-elevated-Colonic Polyps', 'CALCA-occur-Communicable Diseases', 'Metabolism, Inborn Errors-explain-Anemia', 'Weight Loss-be in-Parkinsonian Disorders', 'Weight Loss-be due-INS', 'Renal Insufficiency-characterized-Proteinuria', 'Renal Insufficiency-begin-Gentamicins', 'Gentamicins-characterized-Proteinuria', 'Cardiovascular Diseases-discussed-Coronary Artery Disease', 'Cardiovascular Diseases-discussed-Hypertension', 'Cardiovascular Diseases-discussed-Heart Failure', 'Cardiovascular Diseases-discussed-Myocarditis', 'Gentamicins-accepted-Infections', 'Gentamicins-accepted-Drug-Related Side Effects and Adverse Reactions', 'rs2772300-be in-WLS', 'GH1-contribute-GHRH', 'NFKB1-interact with-WRN', 'WRN-modify-NFKB1', 'WRN-redistribute-NFKB1', 'WRN-coimmunoprecipitate with-NFKB1', 'BLM-map-RECQL4', 'RFWD3-support-PARP1', 'RFWD3-support-POT1', 'RFWD3-support-ATM', 'MAPT-improve-CDK5', 'MAPT-improve-PIN1', 'NDRG2-induce-STAT3', 'GGH-drive-GHRH', 'GGH-amplify-SST', 'POU5F1-known-KLF4', 'POU5F1-known-SOX2', 'FOXC2-constitute-PLIN1', 'AGER-block-RIPK3', 'KLF14-associate-INS', 'INS-associate-KLF14', 'FHL2-associate-INS', 'INS-associate-FHL2', 'AMER3-associate-INS', 'INS-associate-AMER3', 'MAPK1-investigate-EGF', 'RECQL-interact-PARP1', 'IRS2-isoform of-TP53', 'DEFB4A-identified-IL10', 'DEFB4A-identified-IL2', 'DEFB4A-identified-IL4', 'CRP-modify-LEP', 'CRP-cause-LEP', 'LEP-demonstrate-CRP', 'MSH2-quantified-PMS2', 'MSH3-quantified-PMS2', 'MSH6-quantified-PMS2', 'PMS1-quantified-PMS2', 'NPM1-be in-FLT3', 'RAD9A-include-DLAT', 'XPA-include-DLAT', 'RAD9A-include-FIS1', 'XPA-include-FIS1', 'RAD9A-include-NDUFAB1', 'XPA-include-NDUFAB1', 'ANXA5-used-EPOR', 'ANXA5-used-AKT1', 'KL-associated-GH1', 'GH1-associated-KL', 'TLR4-interact-NOTCH1', 'MDM2-detected-TP53', 'PTGDS-up-regulate-ITGAM', 'PTH-accompanied-ALPP', 'PTH-accompanied-BGLAP', 'PTH-accompanied-ALB', 'SIRT1-affect-CDKN2A', 'SIRT1-affect-AKT1', 'SIRT1-accompanied-AKT1', 'MAPK8-suppress-GJA1', 'UCP1-share-UCP3', 'UCP2-attenuate-INS', 'HMGA2-induce-AKT1', 'HMGA2-induce-MTOR', 'EPHA2-interfere with-EFNA1', 'SIRT1-induced-NAMPT', 'NAMPT-induce-SIRT1', 'NAMPT-decrease-SIRT1', 'NAMPT-attenuate-AKT1', 'NAMPT-attenuate-MAPK1', 'NAMPT-upregulate-SIRT1', 'FGF21-suppress-CS', 'CBX1-reside-PCGF1', 'CBX1-reside-PCGF2', 'CBX1-reside-PCGF3', 'CBX1-reside-BMI1', 'CBX1-reside-PCGF5', 'CBX1-reside-PCGF6', 'CBX1-reside-PHC1', 'CBX1-reside-PHC2', 'CBX1-reside-PHC3', 'CBX1-reside-RING1', 'CBX1-reside-RNF2', 'GGH-amplify-GHRH', 'FLT3-regulated-SIRT7', 'FLT3-regulated-EBP', 'SIRT7-regulated-EBP', 'GRN-preserved-PSAP', 'RGN-activate-NFE2L2', 'RGN-activate-KEAP1', 'NR1H4-interact-BDNF', 'NR1H4-prevent-BDNF', 'FASN-be critical effector of-ZNF521', 'AKT1-reduce-TERF1', 'TERF1-phosphorylated-AKT1', 'AQP3-interact-DEDD', 'LEO1-identify-ERCC6', 'LEO1-Consistent result sensitivity damage in-ERCC6', 'GHRH-increase-IGF1', 'NFE2L2-reduce-MTOR', 'GHRH-increase-INS', 'CD8A-rose-CD4', 'TSPO-result-IL6', 'TSPO-result-VEGFA', 'DNMT3A-show level to-LOXL1', 'LOXL1-restored-DNMT1', 'LOXL1-overexpressed-DNMT3A', 'PTTG1-cause-ESPL1', 'INS-express-LPL', 'LPL-promote-GH1', 'MSRB2-affect-MAPT', 'MSRB2-reduce-BACE1', 'MAPT-reversed-MSRB2', 'MAPK8-involve-MSRB2', 'MAPK1-involve-MSRB2', 'MSRB2-reduce-BAX', 'MSRB2-enhance-BCL2', 'BAX-enhance-BCL2', 'GGH-exert actions via-KL', 'NCL-interact-ERCC8', 'NCL-interact-ERCC6', 'ERCC6-increase-NCL', 'ERCC8-enhance binding to-NCL', 'ERCC8-induce-NCL', 'ERCC8-enhance-ERCC6', 'ERCC6-enhance-NCL', 'ERCC4-encode-ERCC1', 'ERCC8-be positive regulators via-NCL', 'ERCC6-be positive regulators via-NCL', 'PTH-correlate-BGLAP', 'KL-affect-MAPK1', 'KL-affect-AKT1', 'IL6R-associated-IL6', 'IL6-associated-IL6R', 'PARP1-associated-IL6', 'IL6-associated-PARP1', 'SOD1-use-CAT', 'PCNA-bind to-WRN', 'CA4-decrease-CA1', 'LEP-measure-INS', 'INS-find-LEP', 'ACBD3-regulate-PARP1', 'PARP1-knock-ACBD3', 'DBH-caused-PHOX2A', 'DBH-reversed-PHOX2B', 'SIRT1-suppress-FOXO3', 'INS-promote-FOXM1', 'INS-regulate-PLK1', 'MAPK1-mediate-HSPB1', 'MAPK1-reveal-HSPB1', 'SRSF1-alter-LMNA', 'NFE2L2-modulate-PRKAB1', 'SRSF1-activate-PRKAB1', 'SRSF1-modulate-LMNA', 'SCO2-couple-TP53', 'TP63-include-TP53', 'TP73-include-TP53', 'CCL2-determined-CCR2', 'SIRT3-stimulate-SIRT5', 'SIRT3-stimulate-SIRT1', 'SIRT5-stimulate-SIRT1', 'MCM2-observed-MCM5', 'AKT1-reduce-MITF', 'AKT1-reduce-CTNNB1', 'MITF-reduce-CTNNB1', 'GH1-produced-GHRH', 'CLOCK-function-SIRT1', 'PTN-observed-VEGFA', 'GH1-taken-GHRH', 'GHRH-compare-GH1', 'AKT1-phosphorylated-THPO', 'FOXO3-phosphorylated-THPO', 'HTT-recruit-BECN1', 'HTT-impair-BECN1', 'GPX4-aggravate-NFKB1', 'CCDC88A-involved-AKT1', 'BGLAP-inhibited-BMP2', 'RUNX2-inhibited-BMP2', 'SP7-altered-BMP2', 'MUC5AC-offset-HMGB1', 'MAPK8-affect-AKT1', 'HSP90AA1-serve-MAPT', 'KL-protect via-NFE2L2', 'TRIB3-inhibit-AKT1', 'SIRT1-result in-FOXO1', 'SIRT1-result-TP53', 'FOXO1-result-TP53', 'SIRT1-different downstream targets with-TP53', 'TPP2-downregulate-MYBBP1A', 'SIRT6-downregulate-MYBBP1A', 'SIRT7-downregulate-MYBBP1A', 'EGF-result-FOS', 'EGF-increase-FOS', 'FDPS-reduce-PLA2R1', 'PLA2R1-mediate-FDPS', 'PLA2R1-mediate aging phenotypes through-FDPS', 'SPRY2-bind-EGFR', 'SPRY2-target-EGFR', 'SPRY2-act from-EGFR', 'SPRY2-impede-EGFR', 'SPRY2-sequester-EGFR', 'POT1-block-WRN', 'POT1-stimulate-WRN', 'POT1-modulate-WRN', 'IL6-co-immunoprecipitate with-MME', 'AGTR1-genotyped-APOE', 'SYP-co-localize with-PIEZO2', 'CYP1A1-be active than-CYP1A2', 'CYP1A1-be variable than-CYP1A2', 'CLU-show-CLUL1', 'ERCC1-form-ERCC4', 'TRPV1-colocalize with-CALCA', 'FOXO3-increase-SIRT3', 'CAT-block-SIRT3', 'CAT-transfer-FOXO3', 'SOD2-transfer-FOXO3', 'WRN-participate in-KAT2B', 'NXF1-associated-PHB2', 'PHB2-associated-NXF1', 'PLIN2-result higher-PLIN5', 'PLIN2-decrease-PLIN5', 'SFRP1-induced-WNT3A', 'ERCC2-organized-CDK7', 'USP14-assess-NFKBIA', 'MAP1LC3A-detected-NUP62', 'STAT1-decrease-TP53', 'STAT1-enhanced-STAT3', 'TP53-enhanced-STAT3', 'RECQL-stimulate-EXO1', 'NFE2L2-suppress-EIF2AK3', 'SST-upregulate-MME', 'TAT-favor-DNM1L', 'SIRT1-promote-MFN2', 'PTK2B-associated-CD4', 'CD4-associated-PTK2B', 'PTK2B-associated-CD8A', 'CD8A-associated-PTK2B', 'CTCF-play role in-ERCC6', 'CTCF-regulate-ERCC6', 'ERCC6-interact with-CTCF', 'RNF138-act-RBBP8', 'RNF138-promote-RBBP8', 'MDM2-act as-WRN', 'MDM2-interact with-WRN', 'MDM2-downregulate-WRN', 'MDM2-induce-WRN', 'MDM2-involved-WRN', 'MDM2-regulate-WRN', 'WRN-regulated-SIRT1', 'HRAS-elucidate-BRAF', 'IMMP2L-activate-GPD2', 'IMMP2L-activate-AIFM1', 'GGH-regulated-GHRH', 'KL-induce-GGH', 'KL-affect-GGH', 'INS-increase-MTOR', 'SOX9-activate-ACAN', 'SOX9-treated-SIRT1', 'SOX9-hypo-acetylated-ACAN', 'ELANE-hydrolyze-ELN', 'CTSG-cleave-ELN', 'AKT1-induce-MTOR', 'TP53-bind-RRAD', 'HSF2-reduced-KL', 'KL-ameliorate-HSF2', 'HDAC4-investigate-COL1A2', 'HDAC4-activate-MAPK8', 'HDAC4-result-COL1A2', 'MAPK8-result-COL1A2', 'SIRT1-include-NFE2L2', 'TRDMT1-include-NFE2L2', 'SMARCA4-caused-LRRK2', 'GCKR-associated-PKD2L1', 'PKD2L1-associated-GCKR', 'HGF-mediated-CCN2', 'CD4-result-IL21', 'ALB-glycated-ITGAM', 'ALB-fail-ITGAM', 'ALB-affect-ITGAM', 'IL4-glycated-ALB', 'IL4-fail-ALB', 'IL13-glycated-ALB', 'IL13-fail-ALB', 'SIRT3-confirm-PRDX1', 'SIRT3-deacetylated-SIRT5', 'SIRT3-confirm-SIRT1', 'PRDX1-deacetylated-SIRT5', 'PRDX1-deacetylated-SIRT1', 'PSENEN-form-ATP6AP1', 'PSENEN-form-PRKAB1', 'PSENEN-blunt-PRKAB1', 'ATP6AP1-blunt-PRKAB1', 'ERCC4-comprise-ERCC1', 'ERCC1-alter-ERCC4', 'GGH-follow-GHRH', 'GGH-restore-GHRH', 'GGH-evoke-GHRH', 'GGH-reverse-GHRH', 'SORCS2-extend-IGF1', 'CELSR2-extend-IGF1', 'SORCS2-extend-IGFBP3', 'CELSR2-extend-IGFBP3', 'SORCS2-extend-GCKR', 'CELSR2-extend-GCKR', 'SORCS2-extend-TNS3', 'CELSR2-extend-TNS3', 'SORCS2-extend-GHSR', 'CELSR2-extend-GHSR', 'SORCS2-extend-FOXO3', 'CELSR2-extend-FOXO3', 'SORCS2-extend-ASXL2', 'CELSR2-extend-ASXL2', 'NFE2L2-augment-PRDX6', 'NFE2L2-augment-CAT', 'PRDX6-caused-NFE2L2', 'HSF1-recruited-HSF2', 'HMOX1-associated-NFE2L2', 'NFE2L2-associated-HMOX1', 'NFE2L2-mediated-MAPK1', 'NFE2L2-mediated-MAPK8', 'NFE2L2-mediated-AKT1', 'NFE2L2-mediated-PRRT2', 'NFE2L2-mediated-PRKAA1', 'IL16-utilize-CD4', 'APOE-associated-AIF1', 'AIF1-associated-APOE', 'PTK2B-increased-INS', 'MTOR-increased-INS', 'INS-increased-RPS6KB1', 'RELB-reduce-TNFSF12', 'RELB-decrease-MMP9', 'RELB-decrease-BMP2', 'TNFSF12-decrease-MMP9', 'TNFSF12-decrease-BMP2', 'RECQL4-formed-RAD51', 'RECQL4-colocalize-PML', 'APOE-enter-LRP1', 'EMD-encode-LMNA', 'OXT-encoded-OXTR', 'WRN-associated-NHEJ1', 'NHEJ1-associated-WRN', 'ERCC1-enhance-KIF11', 'IDH1-show-NPM1', 'ADIPOQ-associated-RETN', 'RETN-associated-ADIPOQ', 'PPARG-overcome-ADIPOQ', 'TP53-bind-WRN', 'SMAD1-overexpress-PLEKHO1', 'ELN-match-LOX', 'PLEKHO1-target-SMURF1', 'SIRT1-interact-WRN', 'WRN-reverse-SIRT1', 'SIRT1-reduce-WRN', 'WRN-deacetylate-SIRT1', 'SIRT1-regulate-WRN', 'ATXN2-trigger-ATXN2L', 'MAPK1-reduce-HAS2', 'NOTCH1-regulate-ID1', 'COL1A2-modulate-NFE2L2', 'INS-caused-INSR', 'RECQL4-destabilize-PINK1', 'TP53-link-IFI16', 'IFI16-lead-TP53', 'IFI16-accompanied-TP53', 'IFI16-result-CDKN1A', 'TP53-derived-CDKN1A', 'WNT3A-induce-CCN4', 'WNT3A-induce-SPP1', 'WNT1-induce-CCN4', 'WNT1-induce-SPP1', 'SIRT1-activate-XRCC6', 'RECQL-associated-RAD51', 'RAD51-associated-RECQL', 'CAT-correlated-ALB', 'MAPT-reduce-BACE1', 'FGF23-require-KL', 'RBM14-interact-PARP1', 'RBMS3-interact-PARP1', 'RETN-induce-INS', 'ADCYAP1-maintain-EGFR', 'PINK1-associated-PRKAA1', 'PRKAA1-associated-PINK1', 'SIRT3-show-SOD2', 'GGH-correlated-INS', 'NFE2L2-exhibit-VTN', 'TTR-associated-CRP', 'CRP-associated-TTR', 'SIRT3-associate-OGG1', 'OGG1-associate-SIRT3', 'OGG1-identify-SIRT3', 'MAPT-observe-PHF1', 'TP53BP1-regulate-LMNA', 'BACE1-result-OCLN', 'SIRT6-explore-COL1A1', 'SIRT6-explore-COL3A1', 'SIRT6-determine-MMP1', 'MDM2-regulated-TP53', 'MDM2-result-CDK2', 'MDM2-result-CDK4', 'TP53-regulated-CDK2', 'TP53-regulated-CDK4', 'SIRT1-enhance-XPC', 'POT1-influenced-TERF1', 'TPP1-influenced-TERF1', 'TINF2-influenced-TERF1', 'SHBG-associated-CD4', 'CD4-associated-SHBG', 'RAPGEF1-increase-ATG5', 'ESRRA-bind-GLS', 'SIRT1-modulate-XRCC6', 'CNR2-associated-CAV1', 'CAV1-associated-CNR2', 'CNR2-associated-FYN', 'FYN-associated-CNR2', 'CNR2-associated-ADRB1', 'ADRB1-associated-CNR2', 'QPCT-associated-CAV1', 'CAV1-associated-QPCT', 'QPCT-associated-FYN', 'FYN-associated-QPCT', 'SIRT1-complex-XRCC6', 'QPCT-associated-ADRB1', 'ADRB1-associated-QPCT', 'GPX1-associated-CAV1', 'CAV1-associated-GPX1', 'GPX1-associated-FYN', 'FYN-associated-GPX1', 'GPX1-associated-ADRB1', 'ADRB1-associated-GPX1', 'COL1A2-associated-CAV1', 'CAV1-associated-COL1A2', 'SIRT1-enhance-XRCC6', 'COL1A2-associated-FYN', 'FYN-associated-COL1A2', 'COL1A2-associated-ADRB1', 'ADRB1-associated-COL1A2', 'CYP11B2-associated-CAV1', 'CAV1-associated-CYP11B2', 'CYP11B2-associated-FYN', 'FYN-associated-CYP11B2', 'CYP11B2-associated-ADRB1', 'ADRB1-associated-CYP11B2', 'ESR2-associated-CAV1', 'CAV1-associated-ESR2', 'ESR2-associated-FYN', 'FYN-associated-ESR2', 'ESR2-associated-ADRB1', 'ADRB1-associated-ESR2', 'MTOR-result-SIRT1', 'MTOR-result-PRKAA1', 'BANF1-control-PARP1', 'RAB8A-modulate-KL', 'BANF1-reset-PARP1', 'RAB8A-regulate-KL', 'RAB8A-associate-KL', 'KL-associate-RAB8A', 'PPARG-inhibit-SIRT1', 'VASH1-increase-SOD2', 'PPARG-interact-SIRT1', 'UAP1-harbor-UAP1L1', 'UAP1L1-activate-OGT', 'UAP1L1-interact-OGT', 'XPA-signal-ATM', 'XPA-signal-ATR', 'BCHE-give-ACHE', 'ASGR1-interact-CERS2', 'WRN-suppressed-TERF2', 'LEP-lost-INS', 'NANOG-bind-SMAD3', 'MTOR-related-NOTCH3', 'SMAD2-mediate-NANOG', 'DUSP4-increase-CD40LG', 'FNDC5-stimulate-SOST', 'FNDC5-stimulate-SPP1', 'ACVRL1-determine-TGFA', 'GPR55-mitigate-NFE2L2', 'GPR55-demonstrate-NFKBIA', 'CRTC1-contain-MTOR', 'CRTC1-contain-RPTOR', 'GCG-involve-PAX6', 'BDNF-found-APOE', 'MAP4K3-phosphorylate-TFEB', 'MAP4K3-involved-MTOR', 'TRADD-include-TNF', 'RIPK1-include-TNF', 'RB1-decrease-NOS3', 'RB1-accompanied-SIRT1', 'NOS3-accompanied-SIRT1', 'SIRT1-blunted-RB1', 'GH1-drawn-GHRH', 'PRRT2-associated-RACK1', 'RACK1-associated-PRRT2', 'GH1-increase-BGLAP', 'CD4-decrease-CD8A', 'NFE2L2-enhance-C3', 'NFE2L2-enhance-C5AR1', 'CFH-increased-C3', 'C3-reduced-C3AR1', 'NFE2L2-generate-C3', 'NLRP3-activate-CASP1', 'CD4-detected-CD8A', 'CTSL-correlate-MMP2', 'DGCR8-interact-LMNB1', 'DGCR8-interact-CDKN3', 'ERCC4-purified-ERCC1', 'GH1-produce-GHRH', 'GH1-fail-GHRH', 'GH1-potentiate-GHRH', 'CD8A-exhibit-CCL4', 'CD8A-result-CCL4', 'BCL2-treated-GZMB', 'IL37-measured-STAT3', 'IL37-confined-CD4', 'KLRB1-reported-CD4', 'IL37-confined-KLRB1', 'INS-separate-GH1', 'NFE2L2-associated-GCLC', 'GCLC-associated-NFE2L2', 'NFE2L2-associated-NQO1', 'NQO1-associated-NFE2L2', 'TAT-hydrolyzed-MME', 'TAT-shown-MME', 'PRL-increase-GHRH', 'HGF-phosphorylate-SRC', 'HGF-phosphorylate-GRB2', 'HIC1-increase-SIRT1', 'SERPINF1-block-PPID', 'SERPINF1-block-UCP2', 'SERPINF1-block-CASP3', 'SERPINF1-block-BAX', 'SERPINF1-block-BCL2', 'SERPINF1-potentiate-AKT1', 'SERPINF1-linked-UCP2', 'TERT-carry-POT1', 'TERT-carry-TERF2IP', 'PDPK1-restore-MTOR', 'TNFSF13-block-TNFRSF17', 'TNFSF13-block-TNFRSF13B', 'ACVRL1-behave-ID1', 'TGFBR1-behave-ID1', 'CFH-seem-ABCA1', 'CFH-seem-ARMS2', 'ABCA1-seem-ARMS2', 'MTOR-function-KL', 'HYAL1-downregulated-HYAL2', 'HYAL1-increased-HYAL3', 'PPP2R5A-target-AKT1', 'ELN-downregulate-MMP1', 'NONO-interact-GSN', 'FOXO1-affect-INS', 'NFE2L2-include-EIF2AK3', 'EIF2AK3-associated-ATF4', 'ATF4-associated-EIF2AK3', 'NFE2L2-uncoupled-EIF2AK3', 'EIF2AK3-uncoupled-BACH1', 'KDR-prevent-TFEB', 'PRKAA2-prevent-TFEB', 'DCN-initiate-KDR', 'DCN-require-PEG3', 'TNF-result-CYSLTR1', 'GGH-decrease-ADIPOQ', 'GGH-decrease-LPL', 'GGH-decrease-ACACA', 'GGH-induce-SP7', 'GGH-induce-TNFRSF11B', 'ELN-maintain-TGFA', 'ITGB3-regulated-CBX7', 'TCIRG1-regulated-CBX7', 'TCIRG1-increased-CBX7', 'CD8A-divide-IL15', 'SLC2A4-contribute-INS', 'IRS2-play-INS', 'MAPK8-involved-SIRT1', 'SIRT1-involved-PRKAA2', 'SIRT5-deacetylate-SIRT3', 'KL-serve-FGF23', 'OTX2-result-TYR', 'OTX2-highlight-MITF', 'OTX2-affect-TYR', 'NR3C1-reduce-NFE2L2', 'PIN1-restore-MAPT', 'FUT1-predicted-BRCA1', 'FUT1-predicted-AGTR1', 'VEGFA-increase-AKT1', 'APOC3-associated-INS', 'INS-associated-APOC3', 'CXCL5-drive-TGFA', 'CXCL8-drive-TGFA', 'CXCL12-drive-TGFA', 'EGFR-required-COL1A1', 'EGFR-associate-COL1A1', 'COL1A1-associate-EGFR', 'MOK-inhibit-HSPA5', 'PRKN-identify-ATP5IF1', 'IL6-reduce-WNT3A', 'TNFRSF11B-associated-CST3', 'CST3-associated-TNFRSF11B', 'OLFM4-controlled-CDKN2A', 'CDKN2A-controlled-THRA', 'CDKN2A-controlled-MAFA', 'CDKN2A-controlled-THRB', 'THRB-bind-CDKN2A', 'THRB-bind-MAFA', 'THRA-bind-CDKN2A', 'THRA-bind-MAFA', 'SOD2-protect-SIRT3', 'CAT-protect-SIRT3', 'SENP3-relieve-SIRT1', 'POMC-mediated-CRH', 'BGLAP-associated-VDR', 'VDR-associated-BGLAP', 'PRKAA1-fail-ERBB2', 'PRKAA1-downregulate-ERBB2', 'SPEN-interact-MSX2', 'NLRP3-contain-HSP90AA1', 'HSP90AA1-study-NLRP3', 'FANCD2-promote-BRCA1', 'FANCD2-promote-BRCA2', 'FANCD2-promote-RAD51', 'AHR-impair-NOS3', 'VWF-exhibit-VEGFA', 'TRPA1-downregulated-NOS3', 'TRPA1-downregulated-NFE2L2', 'TRPA1-downregulated-UCP2', 'TRPA1-prevent-NOS3', 'TRPA1-prevent-NFE2L2', 'TRPA1-preserve-UCP2', 'SIRT1-regulate-FOXO3', 'INS-identify-SIRT1', 'FGFR2-expressed-FGFR1', 'NOL12-increase-FBL', 'NOL12-increase-NCL', 'SRC-reported-MAPK1', 'FOXO3-regulated-MAPK8', 'CLU-detected-ANXA5', 'MST1-activate-TNFSF11', 'TNFSF11-converge-SRC', 'CXCL8-associated-CXCL9', 'CXCL9-associated-CXCL8', 'CCL5-associated-CXCL9', 'CXCL9-associated-CCL5', 'LEP-influence-GH1', 'CDH11-influence-GH1', 'LEP-mediated-GH1', 'EOMES-compare-CD4', 'PRKAB1-promote-FGF21', 'FGF21-activate-ADIPOQ', 'PRKAB1-generate-FGF21', 'PRKAB1-activate-ADIPOQ', 'INSR-activated-INS', 'GGH-elevate-GHRH', 'PRKAA1-restore-SIRT3', 'CTCF-reduce-DNMT1', 'SIRT3-accompanied-PRKAA1', 'SIRT3-accompanied-DNM1L', 'CYP27B1-upregulate-PTH', 'USF3-interact-WNT16', 'USF3-interact-RUNX2', 'USF3-counteract-CREB1', 'PTH-upregulate-CYP27B1', 'USF3-interact-TNFSF11', 'RTEL1-lead-POT1', 'POT1-caused-RTEL1', 'RUNX2-counteract-CREB1', 'MAPK1-associated-IL2', 'IL2-associated-MAPK1', 'GH1-promote-GHRH', 'GHRH-reduce-POMC', 'PLOD1-constitute-GJA4', 'ICAM1-constitute-GJA4', 'LIPC-constitute-GJA4', 'CNR2-constitute-GJA4', 'PRL-increased-TRH', 'NGF-counteract-CXCL8', 'NGF-counteract-IL33', 'NGF-counteract-SPP1', 'NGF-counteract-CCN1', 'NGF-upregulate-NFE2L2', 'CXCL8-counteract-VEGFA', 'FOXO1-correlated-ID3', 'IL33-counteract-VEGFA', 'SPP1-counteract-VEGFA', 'CCN1-counteract-VEGFA', 'DNMT3A-upregulate-NFE2L2', 'HDAC1-upregulate-NFE2L2', 'NGFR-release-IL33', 'NGFR-release-SPP1', 'NGFR-release-CCN1', 'BGLAP-remain-GH1', 'APOE-disrupted-NOS3', 'CDH13-disrupted-NOS3', 'MTHFR-disrupted-NOS3', 'WRN-investigated-RECQL4', 'CDKN2A-methylated-TP73', 'SIRT1-down-regulate-SMAD2', 'DNMT1-include-TRDMT1', 'DNMT1-identified-TRDMT1', 'DNMT1-include-DNMT3A', 'DNMT1-identified-DNMT3A', 'DNMT1-include-DNMT3B', 'DNMT1-identified-DNMT3B', 'DNMT1-include-DNMT3L', 'DNMT1-identified-DNMT3L', 'DNMT3L-enable-TRDMT1', 'NPY-impaired-DPP4', 'INPPL1-demonstrated-INS', 'KL-up-regulated-VDR', 'KL-mediated-FGF23', 'TAT-impact-CD8A', 'CD4-cultured-TAT', 'IRF7-stimulated-TLR9', 'IRF1-stimulated-TLR9', 'AIF1-stimulated-TLR9', 'SIRT1-recognized-MAP1LC3A', 'SLC25A14-show-UCP2', 'WRN-correlated-CD4', 'WRN-correlated-CD8A', 'FOXG1-identified-AR', 'AR-identified-FOXG1', 'AR-known-FOXG1', 'FOXG1-interact-AR', 'AQP4-follow-HMGB1', 'FOXO3-induce-SIRT1', 'SIRT1-improve-FOXO3', 'MTOR-determined-RHO', 'PRKAB1-inhibit-MTOR', 'SHBG-genotyped-AR', 'CDKN1A-confer-TP53', 'SIRT1-shown-TP53', 'SIRT1-shown-MYOD1', 'IL6-induce-TNF', 'TLR4-attenuate-VEGFA', 'BACE1-activate-ADAM10', 'TSPO-increase-GFAP', 'NFE2L2-found-TP53', 'KL-expressed-MITF', 'KL-inhibit-VEGFA', 'SIRT1-interact-ATG7', 'AGER-prime-NLRP3', 'NFE2L2-increase-GLO1', 'NFE2L2-induce-GLO1', 'AHR-inhibit-ACTA2', 'STAT1-offer-PDGFRB', 'RAC1-coupled-RHOA', 'REN-tend-ACE', 'LEP-correlate-GHR', 'INS-associated-GHR', 'GHR-associated-INS', 'LEP-associated-GHR', 'GHR-associated-LEP', 'GHR-correlated-LEP', 'GHR-correlated-INS', 'CXCL10-induce-NAGLU', 'CXCL13-induce-NAGLU', 'FNDC5-associated-BGLAP', 'BGLAP-associated-FNDC5', 'SIRT1-interact-NR3C1', 'NUMB-inhibit-CTSD', 'FGF20-mediated-FGFR1', 'SIRT1-activate-NR3C1', 'SIRT6-induce-HMGB1', 'SIRT1-formed-NR3C1', 'EGR1-upregulate-KL', 'CCR2-associated-APOE', 'APOE-associated-CCR2', 'GH1-compare-GHRH', 'GH1-increase-GHRH', 'NCR1-increase-IL2', 'NCR3-increase-IL2', 'RSL1D1-up-regulate-NOLC1', 'RSL1D1-induce-GTPBP4', 'BNIP3-interact-MAP1LC3A', 'BNIP3L-interact-MAP1LC3A', 'FUNDC1-interact-MAP1LC3A', 'WRN-found-TP53', 'GLI1-transduced-KIF7', 'GLI1-transduced-STK36', 'GLI1-transduced-SUFU', 'GLI1-transduced-DZIP1', 'WRN-form-TP53', 'CDKN2A-associated-CD4', 'CD4-associated-CDKN2A', 'CDKN2A-associated-CD8A', 'CD8A-associated-CDKN2A', 'CDKN2A-associated-KLRG1', 'KLRG1-associated-CDKN2A', 'TERF2-suppress-ATM', 'ATRX-involved-DAXX', 'TNFSF11-induced-WNT5A', 'BTLA-identified-CTLA4', 'RPL26-required-SRSF7', 'CCN1-reduce-COL1A2', 'CCN1-cause-COL1A2', 'RECQL4-co-localize-FEN1', 'INS-inhibit-ISYNA1', 'INS-elevate-MAPK1', 'INS-elevate-BAX', 'AXIN2-silence-CCND1', 'AXIN2-reduce-TCF4', 'POU1F1-enhance-ALPP', 'POU1F1-mitigated-FGF23', 'NFE2L2-induce-MAPK1', 'ADIPOQ-induced-DEFB4A', 'ADIPOQ-recover-PRKAB1', 'ADIPOQ-recover-SIRT1', 'CFH-confirm-HTRA1', 'PRKAB1-lead-FOXO3', 'KCNIP3-interact-CREBBP', 'PRKAB1-phosphorylate-FOXO3', 'MAD2L2-depend-RNF8', 'MAD2L2-depend-TP53BP1', 'MAD2L2-depend-RIF1', 'MAD2L2-act-PAXIP1', 'MAD2L2-act-REV1', 'MAD2L2-act-REV3L', 'MAD2L2-establish-TP53BP1', 'MAD2L2-establish-RIF1', 'FOXO3-mitigated-PRKAA2', 'FOXO3-block-PRKAA2', 'DRD2-control-COMT', 'MAD2L2-restore-RBBP8', 'MAD2L2-restore-EXO1', 'FA2H-result-CERS2', 'PLD2-promote-SNCB', 'APOE-associated-TARDBP', 'TARDBP-associated-APOE', 'PRL-increase-TNFSF11', 'TNFRSF11B-bind-TNFSF11', 'PINK1-promote-TLR9', 'BDNF-activate-NTRK2', 'RARRES2-associated-FGF19', 'FGF19-associated-RARRES2', 'RARRES2-associated-FGF21', 'FGF21-associated-RARRES2', 'FGF19-associated-FGF21', 'FGF21-associated-FGF19', 'KDM6B-promote-KDM4B', 'FOXO4-suppressed-SIRT1', 'SIRT1-bind-FOXO4', 'GADD45A-deplete-SIRT1', 'CPT1B-correlate-SIRT2', 'CPT1B-correlate-SIRT6', 'SIRT1-recruited-PML', 'SIRT1-stimulate-PML', 'NPTXR-associated-MAPT', 'MAPT-associated-NPTXR', 'TNF-regulated-CENPF', 'F8-overlap-VWF', 'KLF14-associated-TRIM59', 'TRIM59-associated-KLF14', 'KLF14-associated-BRCA1', 'BRCA1-associated-KLF14', 'SYT9-control-BDNF', 'SYT9-bypass-ERCC6', 'BDNF-control-ERCC6', 'GGH-elicit-GHRH', 'BDNF-compensate-ERCC6', 'GGH-release-GHRH', 'PGAM5-co-regulate-UTRN', 'MAP2K1-inhibit-MAPK1', 'WRN-contain-BRCA1', 'REN-accumulate-ACE', 'IL10-activate-STAT3', 'IL4-activate-STAT3', 'IL13-activate-STAT3', 'THBS1-increase-TP53', 'NOX1-block-THBS1', 'NOX1-increase-TP53', 'ARNTL-control-PRDX6', 'NFE2L2-disrupt-PRDX6', 'NRGN-associated-MAPT', 'MAPT-associated-NRGN', 'KEAP1-liberated-NFE2L2', 'KEAP1-repress-NFE2L2', 'RELN-examine-APOE', 'RELN-examine-LRP8', 'RELN-examine-VLDLR', 'KEAP1-act-NFE2L2', 'IL6-use-NFKB1', 'GPX4-overexpress-NFKB1', 'GPX4-exhibit-NFKB1', 'STK39-related-STK24', 'STK39-related-SEPHS1', 'SIRT2-associated-KLK3', 'KLK3-associated-SIRT2', 'IGF2BP2-identified-MIS12', 'IGF2BP2-recognize-MIS12', 'METTL3-alleviate-MIS12', 'POMC-cleaved-MME', 'AR-target-MSTN', 'PTH-correlated-BGLAP', 'UGT1A-include-UGT2B15', 'UGT1A-show-UGT2B15', 'IL4-measured-CD8A', 'WRN-stimulate-PCNA', 'NOP10-include-TERT', 'GAR1-include-TERT', 'NAF1-include-TERT', 'NHP2-include-TERT', 'TNFSF11-induce-TRPV6', 'SPP1-induce-TRPV6', 'VDR-drive-CASP14', 'VDR-drive-S100A8', 'VDR-drive-SOSTDC1', 'PARP1-discover-SIRT1', 'CD8A-compare-ITGAE', 'FGF4-bind-KL', 'FGF7-bind-KL', 'HDAC3-identify-SIRT2', 'HDAC3-compare-SIRT2', 'FGF19-bind-KL', 'FGF21-bind-KL', 'VEGFA-differ-TIMP2', 'HFE-lose-TF', 'STUB1-enhance-ARNTL', 'STUB1-bind-ARNTL', 'STUB1-down-regulate-ARNTL', 'STUB1-promote-ARNTL', 'ARNTL-diminish-STUB1', 'STUB1-ubiquitinate-ARNTL', 'OTX2-caused-TP63', 'IL6-associated-ADIPOQ', 'ADIPOQ-associated-IL6', 'CTC1-involved-FOXO4', 'STN1-involved-FOXO4', 'TEN1-involved-FOXO4', 'DLX2-reduce-ATM', 'EIF2AK2-decrease-TNF', 'TP53-result-TGFA', 'ADIPOQ-regulate-NOS3', 'NOS3-promote-ADIPOQ', 'MTNR1A-determined-CYP19A1', 'SYT4-up-regulated-VGF', 'BAG3-down-regulate-VAV3', 'BAG3-down-regulate-APOA1', 'SYT4-down-regulated-VAV3', 'SYT4-down-regulated-APOA1', 'SYT4-remain-BAG3', 'SYT4-remain-INS', 'VAV3-remain-BAG3', 'VAV3-upregulated-VGF', 'APOA1-remain-BAG3', 'APOA1-upregulated-VGF', 'BAG3-remain-INS', 'BAG3-upregulated-VGF', 'SIRT1-inactivate-STAT3', 'FOXO1-initiate-SREBF1', 'FOXO1-overexpress-PTEN', 'FOXO1-accompany-SREBF1', 'PTEN-accompany-SREBF1', 'PTEN-compare-CDKN1A', 'PTEN-downregulated-CDKN1A', 'SETD7-methylate-FOXO3', 'SETD7-deacetylated-SIRT1', 'FOXO3-deacetylated-SIRT1', 'POU5F1-bind-ATP6V0A2', 'SCG2-hyperphosphorylate-MAPT', 'FOXO3-increase-CAT', 'PTBP1-involved-INS', 'SMURF2-interact-SMAD7', 'SMURF2-interact-EP300', 'SMURF2-interact-YY1', 'SMURF2-interact-SIRT1', 'SMURF2-interact-MDM2', 'SMURF2-regulate-SMAD7', 'GRN-compare-IL6', 'GRN-compare-IL10', 'GRN-compare-CXCL10', 'GRN-compare-IL4', 'GRN-compare-IL13', 'SIRT6-ribosylate-PARP1', 'KLF2-result-HMOX1', 'KLF2-result-NQO1', 'KLF2-result-NFE2L2', 'NFE2L2-abrogate-KLF2', 'PARK7-implicated-AR', 'PARK7-implicated-PTEN', 'PARK7-implicated-AKT1', 'PARK7-involved-PTEN', 'PARK7-involved-AKT1', 'HMOX1-induce-NFE2L2', 'MME-down-regulate-MTOR', 'MME-increase-COL1A2', 'SIRT1-improve-INS', 'INS-impact-PRKAA2', 'SIRT1-affect-DNMT1', 'SIRT1-affect-DNMT3B', 'IGF1-predict-IGFBP1', 'CERS5-interact-SDHB', 'TMEM158-upregulated-ETS2', 'NAMPT-associated-ERBB2', 'ERBB2-associated-NAMPT', 'NAMPT-activate-TGFB1', 'LEP-modulate-BGLAP', 'LEP-modulate-INS', 'LEP-stimulate-ADIPOQ', 'BGLAP-stimulate-INS', 'BGLAP-stimulate-ADIPOQ', 'GGH-circulate-IGF1', 'INS-contribute-IGF1', 'AAK1-promote-LRP6', 'SRSF1-result-LMNA', 'SRSF1-shown-C1QBP', 'NR3C2-use-NR4A1', 'SIRT3-demonstrated-SIRT6', 'ACE-impact-ABO', 'ACE-impact-SRY', 'ACE-impact-SOX3', 'ACE-impact-ADAM17', 'SHMT1-identified-TYMS', 'SHMT1-identified-UBE2N', 'SHMT1-identified-FTH1', 'SHMT1-identified-CELF1', 'SIRT1-activate-TLR2', 'SIRT1-phosphorylated-MAPK8', 'RB1-restore-SIRT1', 'RB1-restore-PRKAB1', 'SIRT1-activated-RB1', 'PRKAB1-increase-NOS3', 'PRKAB1-downregulate-SIRT1', 'RB1-increase-NOS3', 'RB1-increase-SIRT1', 'STAT3-implicated-LEP', 'NAMPT-confer-SIRT1', 'GGH-interact-GHRH', 'BDNF-induce-NTRK2', 'MAPT-shown-CDK5', 'HMGB1-correlate-CTSB', 'MYD88-correlate-CTSB', 'SOST-assessed-ALPP', 'AVP-decrease-KL', 'ABCE1-repressed-ACO1', 'EPO-control-PTK2B', 'ANGPT1-act-VEGFA', 'ANGPT2-act-VEGFA', 'SELL-express-ITGAL', 'DNER-decrease-RBPJ', 'VDR-repress-SOSTDC1', 'GSR-elevate-SOD1', 'ELN-connected-HGF', 'MAPK14-regulate-MAPK1', 'CD4-affect-CD8A', 'MMP1-increased-MMP3', 'NFE2L2-promote-CAT', 'SPP1-colocalize-APOE', 'SPP1-colocalize-VTN', 'CYP3A4-smoking-CYP1B1', 'PINX1-knock-TERF1', 'PINX1-recruited-TERF1', 'PTCH1-express-SHH', 'TNF-contribute-CRP', 'LMNA-regulate-CDKN1A', 'HDAC2-unravel-CDKN1A', 'HDAC2-regulate-CDKN1A', 'BACE1-contain-MID1', 'MAPK1-caused-DUSP6', 'VEGFA-mediated-DLL4', 'PTEN-antagonize-AKT1', 'PRL-measure-TRH', 'PRL-decrease-TRH', 'PRL-show-TRH', 'KDR-exhibit-TRPC1', 'TRPC1-lack-KL', 'CD4-produce-TNF', 'BACH1-enhance-GCLC', 'BACH1-enhance-GCLM', 'BACH1-contribute-NFE2L2', 'BACH1-involved-NFE2L2', 'TNFRSF11B-bind-TNFSF10', 'TNFRSF11B-labeled-TNFRSF11A', 'TNFRSF11A-bind-TNFSF11', 'AR-down-regulate-AHSG', 'TNFRSF11A-inhibit-TNFSF10', 'AHSG-abrogated-AR', 'NFE2L2-interact-ATF4', 'EIF2AK3-induce-NFE2L2', 'EIF2AK3-induce-ATF4', 'ATF4-facilitate-NFE2L2', 'ITGAE-mediated-TGFA', 'TERF1-regulated-TINF2', 'TERF1-regulated-PINX1', 'TERF1-control-POT1', 'POT1-regulated-TERF1', 'FOXO3-deacetylate-SIRT1', 'ERCC2-formed-NUP62', 'ERCC2-formed-GTF2H4', 'ERCC2-formed-GTF2H2', 'ERCC2-formed-CCNH', 'ERCC2-required-CCNH', 'ERCC2-formed-MNAT1', 'NFIB-regulate-CDK2', 'CDC25A-regulate-CDK2', 'REN-show-GH1', 'PPARG-regulated-WNT4', 'ELN-denatured-CLU', 'CLU-inhibit-ELN', 'CLU-found-ELN', 'NGF-mediate-MAPT', 'MAPK1-act-ETV6', 'AKT1-act-ETV6', 'ALPP-investigate-CTSB', 'MAPK1-inhibit-MAP2K1', 'MAPK1-result-JUN', 'MAPK8-result-JUN', 'MCM10-regulated-SIRT1', 'SRF-required-PKD1', 'MYC-required-PKD1', 'E2F1-required-PKD1', 'CREB1-required-PKD1', 'LEF1-required-PKD1', 'TCF7-required-PKD1', 'CLOCK-decreased-CRY2', 'ARNTL-decreased-CRY2', 'PER2-decreased-CRY2', 'CLOCK-form-TRIM28', 'MAPK1-transcribed-PTPN7', 'CSNK1G2-co-expressed-RIPK3', 'CYP27B1-result-BGLAP', 'HIF1A-involve-WRN', 'ALPI-contain-BIRC2', 'SHBG-associate-ALB', 'ALB-associate-SHBG', 'BANF1-validated-PARP1', 'BANF1-validated-RBBP4', 'BANF1-validated-DDB1', 'BANF1-validated-DDB2', 'BANF1-associate-DDB2', 'DDB2-associate-BANF1', 'BANF1-known-NONO', 'BANF1-known-PSIP1', 'BANF1-known-HTT', 'BANF1-known-TCOF1', 'INS-explain-SHBG', 'FNDC5-compare-BDNF', 'KL-associated-STC1', 'STC1-associated-KL', 'CLOCK-interact-ARNTL', 'INHBE-regulated-FST', 'CCL2-pretreated-KL', 'TP53-enhanced-SIRT1', 'IGFBP1-reversed-AKT1', 'SIRT7-required-SMARCA5', 'MDM2-inhibit-AKT1', 'COL3A1-related-DDB1', 'COL3A1-related-CAPNS1', 'KRT19-confirmed-MGP', 'CXCL8-show-MPO', 'SIRT1-attenuate-INS', 'ALPP-combine-BMP2', 'INSR-regulated-SRC', 'GRHL1-correlate-INSR', 'APOE-hyperphosphorylate-MAPT', 'SIRT1-inhibit-SIRT3', 'CHAT-observed-ACHE', 'SGK1-decrease-FOXO3', 'MARVELD2-fold-WRAP53', 'WRAP53-impair-MARVELD2', 'TP53BP1-permit-BRCA1', 'ATM-impaired-CD4', 'CHEK2-impaired-CD4', 'BIRC3-observed-XIAP', 'APOE-related-CRP', 'TXNRD1-induced-CYP1A1', 'TXNRD1-regulated-AHR', 'CYP1A1-known-AHR', 'CYP1A1-regulated-AHR', 'THBS1-required-CCN1', 'PRKAA2-induced-HTT', 'SSB-occur-WRN', 'IL7-induce-ACE2', 'CXCR4-correlate-CHI3L1', 'SIRT6-bind-CAT', 'WRN-interact-TERF2', 'WRN-unwind-TERF2', 'TERF2-function-WRN', 'TERF2-demonstrate-WRN', 'ESR1-bind-AR', 'CDKN2A-inhibit-ZEB1', 'PPP2R2C-induced-NR3C1', 'SOD2-cause-TP53', 'SOD2-cause-CDKN1A', 'SOD2-give-TP53', 'HIF1A-composed-ARNT', 'TMEM131-interact-TRAPPC8', 'INS-enhance-LEP', 'ADIPOQ-inhibit-LEP', 'ADIPOQ-augment-INS', 'LEP-inhibit-INS', 'ADIPOQ-induce-APPL1', 'ACD-interact-POT1', 'ACD-interact-TINF2', 'ACD-bind-POT1', 'APOE-regulated-PPARG', 'ACD-heterodimerize-POT1', 'WRN-genotype-TP53', 'NLRP3-downregulated-NFE2L2', 'BCL2L11-driven-CREBBP', 'CREBBP-lead-BCL2L11', 'CREBBP-contribute-BCL2L11', 'UBE2O-interact-RECQL4', 'UBE2O-depend-RECQL4', 'UBE2O-attenuate-RECQL4', 'USP7-interact-UBE2O', 'USP7-interact-RECQL4', 'UBE2O-attenuate-RBBP8', 'GPX3-associated-CYBB', 'CYBB-associated-GPX3', 'SOX11-express-CCND1', 'CCND1-express-SOX11', 'CYP2D6-affect-CYP1A2', 'FOXO3-activate-MSRA', 'TOR1A-target-SOD1', 'GGH-induce-GHRH', 'UCP2-expressed-UCP3', 'UCP2-expressed-SLC25A27', 'UCP3-expressed-SLC25A27', 'OGT-catalyze-OGA', 'MSRB2-reduce-MSRA', 'MSRA-seem-MSRB2', 'APOE-show-ACE', 'WRN-shown-PCNA', 'WRN-interact-PCNA', 'WRN-shown-TP53', 'WRN-interact-TP53', 'NIBAN2-measure-NFE2L2', 'GLO1-lessen-NOS3', 'TFEB-involved-APLN', 'MAP1LC3A-involved-APLN', 'MAPK1-mediate-NFE2L2', 'MAPK8-mediate-NFE2L2', 'PRRT2-mediate-NFE2L2', 'MSH4-associated-ESR1', 'ESR1-associated-MSH4', 'KCNA6-associated-ESR1', 'ESR1-associated-KCNA6', 'ABAT-associated-ESR1', 'ESR1-associated-ABAT', 'APOE-suppress-CCL2', 'APOE-suppress-VEGFA', 'AR-regulate-HMMR', 'PPARG-study-TOMM40', 'PPARG-study-APOE', 'ALPP-related-PTH', 'VEGFA-coupled-AKT1', 'PLD3-found-LAMP2', 'INS-include-LEP', 'PLD3-found-GRN', 'INS-include-ADIPOQ', 'NEFL-predict-MAPT', 'TERF1-limit-WRN', 'TERF2-limit-WRN', 'KLF15-lead-TP53', 'MSTN-interact-FST', 'PRKAB1-phosphorylate-FOXO1', 'FOXO1-phosphorylate-SOD2', 'FOXO1-increase-CAT', 'AR-mediated-ATF3', 'MAPK8-eliminated-MAPK9', 'DPP4-normalize-SIRT1', 'LATS1-phenocopy-NUAK1', 'NUAK1-phosphorylate-LATS1', 'PTGER4-react-KIT', 'SYP-react-KIT', 'TP53-react-KIT', 'BMPR2-increased-TGFBR1', 'BMPR1B-increased-TGFBR1', 'YAP1-involve-AKT1', 'PTEN-involve-AKT1', 'MTOR-involve-AKT1', 'APOE-remain-ADIPOQ', 'FNDC5-induced-HMGB1', 'FNDC5-correlate-HMGB1', 'KL-interact-NFKBIA', 'FOXO1-identify-SIRT1', 'MMP13-identify-TIMP1', 'KDM5B-upregulate-PIK3C3', 'SOD1-increase-SOD2', 'TMEM107-follow-EGR1', 'MAPK8-mediate-ALPP', 'MDM2-result-TP53', 'GH1-activate-JAK2', 'GHR-activate-JAK2', 'GH1-express-GHR', 'SIRT1-regulate-NANOG', 'SIRT1-involve-ELAVL1', 'SIRT1-mediated-CARM1', 'SNAP91-compare-SYP', 'TERT-associated-TERF1', 'TERF1-associated-TERT', 'TERT-associated-TERF2', 'TERF2-associated-TERT', 'KLF6-expressed-KCTD12', 'DUSP2-expressed-KCTD12', 'RBM34-expressed-KCTD12', 'NRF1-found-NFE2L2', 'NRF1-result-GCLC', 'NRF1-result-GCLM', 'KMT5C-target-KAT8', 'VIP-exert-INS', 'FANCD2-overexpress-FANCA', 'EP300-inhibit-TP53', 'TP53-recruited-EP300', 'WRAP53-associate-TP53', 'TP53-associate-WRAP53', 'CLU-relate-HSF1', 'FOXO1-decline-CD8A', 'REN-harbor-AGT', 'REN-treated-SIRT1', 'AGT-treated-SIRT1', 'FCGR2A-bind-CRP', 'LRP2-facilitate-SHBG', 'BAX-associated-BCL2', 'BCL2-associated-BAX', 'MKX-reduce-TNXB', 'WRN-decrease-CHEK1', 'AGTRAP-mediate-SIRT1', 'AGTRAP-reduce-SIRT1', 'CD4-utilize-CD8A', 'INS-associated-ICAM1', 'ICAM1-associated-INS', 'INS-associated-VCAM1', 'VCAM1-associated-INS', 'CS-identify-ERCC6', 'ERCC6-modulate-TFAM', 'KCND3-associated-PGR', 'PGR-associated-KCND3', 'FADS2-associated-PGR', 'PGR-associated-FADS2', 'IL17D-associated-PGR', 'PGR-associated-IL17D', 'MICU2-associated-PGR', 'PGR-associated-MICU2', 'LRCH1-associated-PGR', 'PGR-associated-LRCH1', 'CS-associated-ERCC6', 'ERCC6-associated-CS', 'SIRT1-shown-ADAM10', 'SIRT1-affect-ADAM10', 'SIRT1-inhibit-MTOR', 'PRKAA2-serve-MTOR', 'MTOR-contribute-PRKAA2', 'VIM-extend-GFAP', 'SIRT1-bind-AR', 'AKT1S1-regulated-PIM1', 'MTOR-bind-AKT1S1', 'SIRT1-induce-AR', 'SIRT1-inhibit-AR', 'REV3L-form-MAD2L2', 'REV3L-form-POLD2', 'REV3L-form-POLD3', 'LEP-correlated-PTH', 'OMA1-cause-DELE1', 'OMA1-bind-EIF2AK1', 'DELE1-bind-EIF2AK1', 'ECE1-lack-APOE', 'GLRX-increase-HSPD1', 'BRCA2-bind-SEM1', 'BRCA2-associate-PCID2', 'PCID2-associate-BRCA2', 'SEM1-associate-PCID2', 'PCID2-associate-SEM1', 'KL-block-PARP1', 'UQCRC1-associated-NRDC', 'NRDC-associated-UQCRC1', 'UQCRC1-associated-CTSB', 'CTSB-associated-UQCRC1', 'UQCRC1-associated-CTSD', 'CTSD-associated-UQCRC1', 'SOST-up-regulate-DMP1', 'SOST-increase-LEF1', 'ERCC6-regulate-OGG1', 'GGH-increase-ALPP', 'GGH-upregulate-ALPP', 'GGH-upregulate-BGLAP', 'GGH-upregulate-RUNX2', 'PPARA-reverse-INS', 'CD4-associated-MPO', 'MPO-associated-CD4', 'CD7-associated-MPO', 'MPO-associated-CD7', 'MAPT-associated-IL5', 'IL5-associated-MAPT', 'MAPT-associated-IL4', 'IL4-associated-MAPT', 'INS-induce-AKT1', 'IGF1-reduce-AKT1', 'CHEK1-ensue-RELA', 'LRP5-decrease-SOX2', 'MMP1-increase-HAS2', 'MMP1-decrease-PDPN', 'CRP-express-FCGR2B', 'MAPK1-abrogate-CAMSAP3', 'MAPK1-suppress-CCND1', 'CAMSAP3-suppress-CCND1', 'VIM-required-MAPK1', 'WNT2-upregulate-SFRP1', 'CD4-silencing-TERF2', 'ERCC6-implicate-NCL', 'CYCS-increase-GAPDH', 'BCL2-occur-TP53', 'FOXO1-enable-FOXP2', 'MSTN-contain-INHBE', 'MSTN-contribute-GDF11', 'IGF1-progress-GH1', 'PRKAA2-involved-GAPDH', 'PRKAA2-regulate-GAPDH', 'CD7-up-regulated-CD2', 'DBH-determined-APOE', 'SHH-suppress-CASP9', 'VEGFA-expressed-KDR', 'SHH-suppress-CASP8', 'APOE-point-HSPA14', 'CETP-point-HSPA14', 'IL1A-combine-IL3', 'NPM1-associated-KIT', 'KIT-associated-NPM1', 'SOD2-inhibit-CAT', 'ADIPOQ-correlate-INS', 'WRN-co-localize-MRE11', 'WRN-associate-MRE11', 'MRE11-associate-WRN', 'WRN-bind-NBN', 'MRE11-bind-NBN', 'CDKN1A-result-CDKN3', 'CRP-obtained-IL6', 'KAT2A-regulate-YY1', 'CSNK1A1-modify-TP53', 'PRKAA2-show-STK11', 'STK11-represent-PRKAA2', 'STK11-represent-ADIPOQ', 'WRN-express-EXD3', 'MSN-decreased-PON1', 'LMNA-processed-ZMPSTE24', 'INS-blunt-PRL', 'HTT-explain-ATXN3', 'ATN1-explain-ATXN3', 'ATXN2-explain-ATXN3', 'MYB-known-TERF1', 'IGF1-treated-GH1', 'NFKB1-associated-HDAC1', 'HDAC1-associated-NFKB1', 'CTCF-associated-HDAC1', 'HDAC1-associated-CTCF', 'ROCK2-normalized-PGK1', 'MYLK-normalized-PGK1', 'ROCK2-show-ROCK1', 'BMP7-result-DCTN6', 'BMP7-induce-SMAD3', 'HSF1-represent-PRKCI', 'CDKN2A-inhibit-KL', 'TP53-inhibit-KL', 'GGH-result-IGF1', 'SOD2-increase-FOXO3', 'CAT-increase-FOXO3', 'CD1D-express-KLRB1', 'CD1D-presented-CD8A', 'KLRB1-express-CD8A', 'WRN-bind-TERF2', 'WRN-demonstrated-TERF2', 'GGH-reduce-GHRH', 'GGH-increase-GHRH', 'GGH-disclose-GHRH', 'WRN-interact-WRNIP1', 'WRN-interact-RAD18', 'WRN-interact-RAD51', 'WRNIP1-interact-RAD18', 'WRNIP1-interact-PCNA', 'WRNIP1-interact-RAD51', 'ACE-result-INS', 'GZMA-govern-TLR4', 'CCN1-normalize-COL1A2', 'LMNA-secrete-BGLAP', 'RUNX2-decreased-LMNA', 'LMNA-increase-TNFSF11', 'LMNA-decreased-TNFRSF11B', 'TNFSF11-decreased-TNFRSF11B', 'VRK1-phosphorylate-BANF1', 'BANF1-form-LMNA', 'BANF1-form-EMD', 'INS-routed-LNPEP', 'PPIA-exhibit-ACTB', 'SIRT1-recruit-SENP1', 'SIRT3-found-MRPL10', 'DCT-regulated-MITF', 'TNFRSF11B-associated-SHBG', 'SHBG-associated-TNFRSF11B', 'TACR3-encode-GNRH1', 'CP-decrease-ALB', 'S100A6-up-regulated-CALR', 'IGF1-decline-GH1', 'GH1-spliced-IGF1', 'PRL-evaluate-POMC', 'TP53-caused-HJURP', 'ESR1-assess-VDR', 'CDKN2A-caused-HJURP', 'ACVR2B-mediate-TGFA', 'SMAD2-mediate-TGFA', 'CHRDL1-mediate-TGFA', 'MAPT-cause-CDK5', 'SIRT2-displayed-SIRT1', 'SIRT2-displayed-SIRT3', 'IGF2BP2-promote-HMGA1', 'HMGA1-suppress-GRB14', 'GAS6-correlated-CST3', 'HTRA2-include-HTRA1', 'HTRA3-include-HTRA1', 'HTRA4-include-HTRA1', 'RB1-abolished-AR', 'RB1-abolished-ESR1', 'LMNA-implicated-INS', 'RB1-transactivate-GAS6', 'ABCG2-facilitated-PDZK1', 'SIRT3-regulate-SOD2', 'GH1-induce-GHRH', 'GH1-increased-GHRH', 'CERS2-result-BCL2', 'CERS2-result-COL11A2', 'FOXO4-modulate-PSMD11', 'SIRT1-decreased-MDH1', 'MDH1-cause-SIRT1', 'TP53-associate-PARP1', 'PARP1-associate-TP53', 'TP53-lead-CDKN1A', 'TP53-lead-MDM2', 'PARP1-lead-MDM2', 'SIRT1-reveal-INS', 'SIRT1-reveal-PRKAA2', 'FGF9-decrease-MYOG', 'FGF9-increase-ICAM1', 'FGF9-increase-WNT1', 'FGF9-increase-WNT6', 'SMAD2-block-TGFBR2', 'SMAD3-block-TGFBR2', 'GHRH-increase-GHR', 'MMP26-degrade-VTN', 'MMP26-degrade-IGFBP1', 'XRCC1-show-ERCC2', 'XRCC1-indicate-ERCC2', 'CAT-associated-IL6', 'IL6-associated-CAT', 'CAT-associated-STIL', 'STIL-associated-CAT', 'FOXO3-appear-EPO', 'FOXO3-function-AKT1', 'FOXO3-function-EPO', 'EPO-become-FOXO3', 'FOXO3-play-EPO', 'FOXO3-undergo-EPO', 'KL-function-FGF23', 'AKT1-induce-NTRK1', 'CCND1-induce-NTRK1', 'BGLAP-use-ALPP', 'PARP1-inhibit-TERF1', 'CCAR2-act-SIRT1', 'CCAR2-promote-SIRT1', 'CCAR2-interact-SIRT1', 'CD4-determined-PTPRC', 'CD4-generate-PTPRC', 'CD2-identify-CD8A', 'PPARG-inhibit-POU5F1', 'PPARG-recover-POU5F1', 'PPARG-reveal-POU5F1', 'APOE-suggested-AKT1', 'FOXO3-suggested-AKT1', 'FOS-comprise-JUN', 'MDM2-promote-FOXO1', 'MDM2-cause-FOXO3', 'MDM2-act-TP53', 'MDM2-bind-FOXO1', 'TNFSF11-promote-CTSK', 'TNFSF11-performed-CTSK', 'TP53-shown-BBC3', 'TP53-shown-BAX', 'AKT1-activated-RGN', 'CALM1-regulate-AKT1', 'RGN-regulate-AKT1', 'ERCC6-interact-NEIL1', 'FOXO3-increased-IGFBP3', 'FOXO3-induce-MAP1LC3A', 'FOXO1-result-GPX1', 'FOXO1-result-CAT', 'FOXO1-result-MAP1LC3A', 'FOXO1-result-SIRT1', 'ERCC6-regulate-TP53', 'ERCC6-regulate-TXNIP', 'C3-bind-C3AR1', 'GAD1-named-GAD2', 'APOE-confirm-BIRC2', 'APOE-confirm-APOB', 'LAG3-decrease-RGS2', 'PDCD1-decrease-RGS2', 'TIGIT-decrease-RGS2', 'SIRT1-display-INS', 'VCAM1-decrease-RGS2', 'SIRT1-down-regulated-INS', 'DDIT4-tend-PRKAA1', 'NSMCE2-increase-BLM', 'CDK4-correlated-CDKN2A', 'CDK6-expressed-CDKN2A', 'CDKN2A-described-CDK4', 'MFN1-decreased-MFN2', 'WRN-regulate-NMNAT1', 'CNR1-correlate-CNR2', 'ANG-induce-XBP1', 'ANG-promote-XBP1', 'FOXO3-down-regulated-APOE', 'SIRT6-increase-MSR1', 'FOXO3-increased-TP53', 'APOE-increased-TP53', 'OGG1-inhibit-RAD52', 'OGG1-interact-RAD52', 'RAD52-colocalize-OGG1', 'NFE2L2-increase-HMOX1', 'RTEL1-interact-TERF1', 'SIRT1-investigate-TP53', 'CDKN2C-downregulated-HTRA4', 'PCNA-downregulated-HTRA4', 'CALR-downregulated-HTRA4', 'CHEK2-downregulated-HTRA4', 'NOX4-downregulated-HTRA4', 'SERPINF1-increased-INS', 'AHSG-increased-INS', 'INS-increased-ADIPOQ', 'TUFM-increase-BACE1', 'TUFM-express-BACE1', 'GGH-decrease-GHR', 'SIRT3-interact-LDHA', 'AQP1-enhance-BACE1', 'AQP1-decrease-BACE1', 'CYFIP2-implicated-GABRA3', 'ATXN2-affect-PABPC1', 'SIRT1-attenuate-FOXO3', 'TNF-enhance-CX3CL1', 'CFH-attenuate-FOXO3', 'CFH-enhance-FOXO3', 'SIRT1-induce-HSP90AA1', 'HSP90AA1-required-SIRT1', 'SIRT1-remain-SIRT2', 'SIRT2-reflect-HSP90AA1', 'HSP90AA1-lead-SIRT1', 'SIRT1-identify-HSP90AA1', 'GSDMC-play-MAPK1', 'GSDMC-play-MAPK8', 'ZC3H12A-identify-NR1I3', 'CS-co-immunoprecipitate-FXN', 'BUB1B-cause-DSC1', 'CCL5-found-CCND1', 'WRN-use-RAD51', 'HELLS-recruit-HDAC1', 'TNF-correlate-CRP', 'AMH-increase-INS', 'AMH-increase-SHBG', 'SIRT3-interact-FOXO1', 'SIRT1-increase-NOS3', 'SIRT1-increase-TP53', 'SIRT1-decrease-NOS3', 'TP53-decrease-NOS3', 'NCF2-regulate-TLR4', 'NOS3-increase-HSF1', 'NOS3-increase-CRP', 'NOS3-regulate-TLR4', 'CAT-increase-HSF1', 'CAT-regulate-TLR4', 'HSF1-regulate-TLR4', 'CRP-regulate-TLR4', 'KL-correlated-IL10', 'KL-correlated-CRP', 'DDIT3-reduced-XBP1', 'XBP1-increase-DDIT3', 'KL-associate-PTH', 'PTH-associate-KL', 'KL-use-PTH', 'PTH-measured-ALPP', 'SLC18A2-parallel-TH', 'SLC6A3-parallel-TH', 'CXCL8-decrease-IL10', 'MMP3-decrease-IL10', 'MMP10-decrease-IL10', 'TIMP2-decrease-IL10', 'KL-stimulate-INS', 'UBIAD1-enhance-HMGCR', 'FGF7-activate-NFE2L2', 'NFE2L2-enhanced-FGF7', 'CD40-regulate-CD40LG', 'CD40-elicit-CD40LG', 'TP53-screened-CDC42', 'IL5-used-STAT6', 'IL5-used-GATA3', 'MAPK14-followed-BAX', 'SORL1-determine-BDNF', 'LEP-become-INS', 'MSRB2-expressed-MSRB1', 'MSRB2-expressed-MSRB3', 'TP53-reduce-LIF', 'LONP1-interact-HSPA8', 'CDC6-concur-TP53', 'CDC6-followed-MCM2', 'TP53-followed-MCM2', 'HSP90AA1-reduce-CDKN2A', 'INS-associated-FOXO3', 'FOXO3-associated-INS', 'FOXO3-induce-ATM', 'WRN-lead-RAD51', 'WRN-lead-BLM', 'WRN-silence-TP53', 'AKT1-enhance-NANOG', 'AKT1-stimulate-NANOG', 'TRPV6-related-VDR', 'INS-judge-AKT1', 'KL-study-INS', 'KL-regulate-INS', 'KL-regulate-FGF23', 'INS-regulate-FGF23', 'ZEB2-co-expressed-POU3F2', 'ZEB2-co-expressed-POU3F3', 'ZEB2-co-expressed-POU2F2', 'PPARGC1A-implicated-SIRT1', 'BAX-result-BCL2', 'SIRT2-dephosphorylate-CDC14A', 'SIRT2-dephosphorylate-CDC14B', 'PARP1-bind-NEIL1', 'SMN1-produce-SMN2', 'BNIP3-required-BNIP3L', 'CD8A-result-CD4', 'ALPP-encode-COL1A1', 'GH1-restore-GHRH', 'GH1-stimulated-GHRH', 'TP53-induced-MAPT', 'EPS15-interact-DYSF', 'LAG3-characterise-CERS1', 'DYRK1A-phosphorylate-SIRT1', 'DYRK3-phosphorylate-SIRT1', 'ARNTL-prime-PER2', 'DYRK1A-promote-SIRT1', 'SIRT1-studied-SIRT7', 'TREM2-interact-TYROBP', 'SUMO1-dysregulate-SENP1', 'SUMO1-overexpress-SP1', 'SUMO1-show-SP1', 'TERF2IP-bind-TERF1', 'RIF1-bind-TERF1', 'TERF2IP-bind-TINF2', 'RIF1-bind-TINF2', 'TERF2IP-bind-TNKS', 'RIF1-bind-TNKS', 'CCR5-express-CD8A', 'CCR6-express-CD8A', 'ACE-associated-APOE', 'APOE-associated-ACE', 'ALB-fell-CRP', 'SST-suppress-MME', 'IGF1-affect-IGF1R', 'IGF1-result-IGF1R', 'IGF1-caused-IGF1R', 'IGF1-result-EGR1', 'IGF1-include-EGR1', 'IGF1-result-PHLDA1', 'IGF1-include-PHLDA1', 'IGF1R-result-EGR1', 'IGF1R-result-PHLDA1', 'WRN-mediate-VEGFA', 'WRN-mediate-EGF', 'CD4-measure-IL2', 'CD8A-measure-IL2', 'CD4-measure-IL4', 'CD8A-measure-IL4', 'SIRT6-find-NFE2L2', 'SIRT6-find-HMOX1', 'SIRT1-augment-INS', 'ABCA1-associate-CRP', 'CRP-associate-ABCA1', 'ABCA1-reduced-CRP', 'ABCG1-associate-CRP', 'CRP-associate-ABCG1', 'ABCG1-reduced-CRP', 'MT-CO2-stimulate-VEGFA', 'MT-CO2-stimulate-IL1B', 'MT-CO2-stimulate-NLRP3', 'HGF-encoded-SLTM', 'SIRT6-lead-MAPT', 'PIN1-enhance-TERF1', 'PIN1-render-TERF1', 'YAP1-correlate-ERBB2', 'ATG7-lipidate-GABARAPL1', 'NFE2L2-supply-TXN2', 'PLIN2-appear-PLIN3', 'PLIN2-appear-PLIN5', 'KEAP1-bind-CUL3', 'IRF4-affect-BCL6', 'SLC13A3-inhibit-SIRT1', 'SLC13A3-treated-SIRT1', 'BMP2-known-PDE4D', 'BMP2-interact-PDE4D', 'BGLAP-increase-SHBG', 'COL1A2-increase-SHBG', 'KL-suppress-EIF2AK2', 'PPARA-increase-NOTUM', 'TERT-cooperate-GDF11', 'TERT-represent-GDF11', 'TERF2IP-recruited-TERF2', 'TERF2IP-influence-TERF2', 'FGF23-associated-CST3', 'CST3-associated-FGF23', 'DDR2-lead-CDKN1A', 'DDR2-increase-JAK2', 'DDR2-decrease-CDKN1A', 'JAK2-increase-CDKN1A', 'IRF1-evaluate-INS', 'AQP4-reduced-ALDH2', 'ALDH2-determined-AQP4', 'IRF1-associated-INS', 'INS-associated-IRF1', 'AIF1-associated-MAPT', 'MAPT-associated-AIF1', 'IL10-associated-MAPT', 'MAPT-associated-IL10', 'IL13-associated-MAPT', 'MAPT-associated-IL13', 'CD8A-associated-CRP', 'CRP-associated-CD8A', 'RECQL5-reduced-PCNA', 'RECQL5-suppress-CHEK1', 'KL-associated-INS', 'INS-associated-KL', 'BAX-silence-KL', 'AMH-vary-INS', 'BRCA1-associated-AMH', 'AMH-associated-BRCA1', 'TMEM106B-associate-TARDBP', 'TARDBP-associate-TMEM106B', 'PER2-altered-PER3', 'HTR2A-coupled-ARRB1', 'HTR2A-coupled-GSK3B', 'HTR2A-coupled-AHCYL1', 'MRE11-include-NBN', 'RAD50-include-NBN', 'MRE11-include-RAD50', 'SIRT1-determined-CD8A', 'PIN1-become-MAPT', 'SP4-contain-SP6', 'SERPINB2-reduce-TPP2', 'SIRT1-followed-SIRT6', 'SIRT3-followed-SIRT6', 'SIRT1-interact-AKT1', 'ALDH1A1-regulate-PPARG', 'ALDH1A1-rescue-RARA', 'TXNIP-repressed-FOXO1', 'TNFSF11-exhibit-RUNX2', 'INSL3-comprise-JAK3', 'INSL3-encoded-RXFP2', 'JAK3-encoded-RXFP2', 'TSC2-regulate-MTOR', 'RPS6KB1-regulate-MTOR', 'ACHE-concentrated-CA1', 'WWP1-function-SMAD2', 'WWP1-function-KLF5', 'WWP1-function-TP63', 'WWP1-function-RUNX2', 'WWP1-function-JUNB', 'WWP1-function-RNF11', 'WWP1-function-SPART', 'WWP1-function-SMAD4', 'WWP1-function-KLF2', 'WWP1-function-EPS15', 'FLCN-regulate-MTOR', 'MSRA-require-MSRB2', 'NR3C1-shown-INS', 'PPARG-modulate-NOX1', 'SLC2A4-measured-VEGFA', 'SLC2A4-measured-PRKAA1', 'SLC2A4-measured-PPARGC1A', 'SLC2A4-measured-TFAM', 'VEGFA-measured-PRKAA1', 'VEGFA-measured-PPARGC1A', 'VEGFA-measured-TFAM', 'PRKAA1-increase-VEGFA', 'TP53-induce-TRIM29', 'TP53-reduce-ATM', 'TRIM29-reduce-ATM', 'CDKN2A-suppress-TP53', 'GGH-increase-TP53', 'PCNA-investigate-BCL2', 'CDK5-enhance-MAPT', 'GGH-stimulate-GHRH', 'GGH-stimulate-CRH', 'BCHE-compare-ACHE', 'INS-increase-VEGFA', 'DNAJC7-contain-HSP90AA1', 'SIRT1-reduce-FOXO3', 'FOXO3-decrease-CCL20', 'HLA-DRB1-attributed-CTSS', 'RPS6-include-MTOR', 'INS-activate-PPARG', 'OPTN-function-RAB8A', 'OPTN-function-HTT', 'USP28-recruited-TP53BP1', 'USP28-require-TP53BP1', 'KL-promote-FGF23', 'COX8A-alleviate-COX15', 'COX8A-silence-COX10', 'MTOR-prove-RPTOR', 'CHI3L1-induced-ACE2', 'CHI3L1-induced-HM13', 'TM2D3-confirm-RHOB', 'APOE-associated-APOB', 'APOB-associated-APOE', 'BGLAP-lie-INS', 'EGF-stimulate-ENO2', 'EGF-stimulate-SLC18A3', 'LRRK1-base-LRRK2', 'GNG2-interact-CXCL1', 'GNG2-interact-CCR7', 'GNG2-associated-ACSS2', 'ACSS2-associated-GNG2', 'CXCL1-associated-ACSS2', 'ACSS2-associated-CXCL1', 'CCR7-associated-ACSS2', 'ACSS2-associated-CCR7', 'KL-shown-SLC1A1', 'KL-shown-SLC1A6', 'SIRT1-cause-PARP1', 'FOXO3-associated-FOXO1', 'FOXO1-associated-FOXO3', 'TMEM39A-bind-SEC23A', 'DST-known-COL17A1', 'TBC1D10B-inactivate-RAB35', 'GNRH1-do-TRH', 'GHRH-promote-NPY', 'CD4-identified-CD8A', 'DMD-overexpress-ITGA7', 'IL10-compare-CRP', 'CXCL5-promote-CXCL1', 'CXCL1-promote-CXCL12', 'CHEK1-lead-TP53', 'TRAF6-ubiquitinate-MYC', 'MTOR-regulate-MAPT', 'MTOR-lead-MAPT', 'BACE1-express-MTOR', 'ULK1-serve-TFEB', 'ULK1-serve-FOXO1', 'ULK1-serve-ATF4', 'ULK1-serve-DDIT3', 'ATF4-diminish-AKT1', 'PRKAA1-diminish-AKT1', 'SIRT1-diminish-AKT1', 'EIF5A-diminish-AKT1', 'DNMT1-decrease-DNMT3B', 'DNMT3A-decrease-DNMT3B', 'AKT1-interact-ESR1', 'TERF1-involve-TNKS', 'ESR1-interact-AKT1', 'ATM-involve-TERF1', 'SOD1-show-GPX2', 'TGFA-result-SPI1', 'ADNP-discovered-NMNAT1', 'CD4-display-BATF', 'CD4-display-IRF4', 'CD4-display-ID3', 'CD4-display-BCL6', 'RBBP8-identify-SIRT6', 'RBBP8-facilitate-SIRT6', 'APOE-mediate-CRP', 'NAMPT-convert-SIRT1', 'AMBRA1-regulate-HUWE1', 'AMBRA1-controlled-HUWE1', 'CRH-impair-NPY', 'NOS3-decrease-NR3C2', 'SOX2-employed-POU5F1', 'KLF4-employed-POU5F1', 'PTPN11-phosphorylated-PDGFRB', 'LMNA-reduce-RUNX2', 'SIRT1-cause-TP53', 'SIRT1-induce-PPARGC1A', 'PRKAA1-act-SIRT1', 'NFASC-reduce-BAX', 'NFASC-reduce-BCL2', 'NFASC-reduce-CASP9', 'NFASC-reduce-CASP3', 'PTEN-comprise-AKT1', 'PTEN-comprise-AKT2', 'NFE2L2-indicate-KEAP1', 'NFE2L2-trigger-NFASC', 'KEAP1-trigger-NFASC', 'SIRT1-lead-SOX5', 'ZFAND2A-miss-ZFAND2B', 'ZFAND2A-share-ZFAND2B', 'CR1-bind-C3', 'BRCA2-measure-AMH', 'BRCA1-measure-AMH', 'KNG1-mediated-ACE', 'AKT1-required-TP53', 'AKT1-induce-TP53', 'TP53-follow-AKT1', 'TP53-induce-AKT1', 'CXCL8-abrogated-AKT1', 'AKT1-increase-NOX4', 'AKT1-increase-TP53', 'ADIPOQ-correlated-PPARG', 'WRN-involved-ATM', 'DTX3L-identified-PARP9', 'DTX3L-known-PARP9', 'DTX3L-form-PARP14', 'XRCC1-accumulate-PARP1', 'INS-caused-GIP', 'LEP-assess-INS', 'ADIPOQ-assess-INS', 'CST3-correlate-CRP', 'CST3-correlate-TNF', 'CD8A-carry-CYBB', 'CD8A-release-CD4', 'CYBB-taken-CD4', 'SLC41A1-induce-BAX', 'SESN3-increase-MSTN', 'NFE2L2-result-PRKAA1', 'MRFAP1-bind-MAS1L', 'LEP-observed-ADIPOQ', 'TSPAN15-identify-ADAM10', 'TSPAN15-associate-ADAM10', 'ADAM10-associate-TSPAN15', 'TSPAN15-cause-ADAM10', 'ADNP-regulated-MAPRE1', 'ADNP-seem-MAPRE1', 'MAPRE1-regulated-SIRT1', 'ADNP-seem-MAPRE3', 'INS-associated-TBC1D4', 'TBC1D4-associated-INS', 'INS-associated-AKT1', 'AKT1-associated-INS', 'INS-reverse-TBC1D4', 'INS-contribute-TBC1D4', 'RUNX2-include-BMP2', 'ALPP-include-BMP2', 'BGLAP-include-BMP2', 'SIRT1-modulate-NFKB1', 'NOVA2-regulate-SCN1A', 'FOS-slow-FTO', 'FTO-alleviate-FOS', 'GDF11-resolved-MSTN', 'CS-arise-ERCC8', 'CS-arise-ERCC6', 'KL-form-SOD2', 'MDM2-activated-AKT1', 'MDM2-block-AKT1', 'ARRB1-facilitate-MDM2', 'CTC1-decrease-STN1', 'WRN-associate-SUV39H1', 'SUV39H1-associate-WRN', 'MDM2-identified-TP53', 'MDM2-associate-TP53', 'TP53-associate-MDM2', 'DDX53-improve-S100A8', 'SELENOP-cause-INS', 'SERPINA12-associate-ADIPOQ', 'ADIPOQ-associate-SERPINA12', 'SERPINA12-associate-INS', 'INS-associate-SERPINA12', 'CTCF-result-IGF2', 'PSAP-inhibit-TLR9', 'GRN-inhibit-TLR9', 'NPY-produce-GRP', 'SST-produce-GRP', 'VIP-produce-GRP', 'CTSD-assessed-NOS3', 'SIRT1-assessed-NOS3', 'IL2-result-CD8A', 'IL6-result-CD8A', 'STK11-inhibited-SIRT1', 'HERC2-downregulate-STK11', 'SIRT1-result-STK11', 'SIRT1-downregulate-STK11', 'HERC2-result-STK11', 'LYZ-limit-ELN', 'LYZ-prevent-ELN', 'PCP2-employed-BCL2', 'FOXO3-target-FOXP3', 'CEMIP2-increase-MAPK1', 'SIRT2-up-regulate-CASP3', 'SIRT2-down-regulate-BAX', 'TRPV1-reduced-SIRT6', 'SIRT6-accompanied-ALPP', 'SHBG-related-INS', 'NPY-correlated-POMC', 'POMC-increase-NPY', 'GH1-augment-GHRH', 'GH1-stimulate-GHRH', 'GH1-drove-GHRH', 'ENHO-supported-NOS3', 'UCP1-measure-ATP2A1', 'PRKAA1-counteract-UCP1', 'KL-improve-CASP3', 'MRE11-regulate-RECQL4', 'RECQL4-affect-MRE11', 'RECQL4-interact-RBBP8', 'RECQL4-impair-RBBP8', 'POLD1-associate-POLD2', 'POLD2-associate-POLD1', 'POLD1-associate-POLD3', 'POLD3-associate-POLD1', 'POLD1-associate-POLD4', 'POLD4-associate-POLD1', 'FOXO3-involved-ATM', 'FOXO3-form-INS', 'RPS6KB1-include-MTOR', 'KLK1-upregulate-NOS3', 'INS-contribute-LEP', 'INS-related-LEP', 'LEP-bind-LRP2', 'NAMPT-modulate-SIRT1', 'LEP-represent-LRP2', 'SIRT1-regulate-ARNTL', 'SIRT1-regulate-PER2', 'GC-associated-ALB', 'ALB-associated-GC', 'CTSV-followed-CTSK', 'CTSV-corroborate-ELN', 'CTSK-corroborate-ELN', 'CD8A-co-express-KLRG1', 'CBX4-recruit-FBL', 'CBX4-recruit-TRIM28', 'AKT1-promote-SOX9', 'MALAT1-named-TALAM1', 'Trehalose-reduce-Sucrose', 'Glycosaminoglycans-constituted-Disaccharides', 'Glycosaminoglycans-discover-Glucuronic Acid', 'Polysaccharides-enhance-Glycosaminoglycans', 'Fructose-exert-Glucose', 'Phlorhizin-reduce-Sugars', 'Polysaccharides-composed-Alginic Acid', 'Monosaccharides-include-Mannose', 'Monosaccharides-include-Xylose', 'Monosaccharides-include-Fucose', 'Monosaccharides-include-Glucuronic Acid', 'Monosaccharides-include-Glucose', 'Monosaccharides-include-Galactose', 'Polysaccharides-contain-Monosaccharides', 'Fructosamine-increase-Glucose', 'Monosaccharides-detected-Mannose', 'Anthocyanins-increase-Glycosides', 'Canagliflozin-avoided-Glucose', 'Glycogen-fed-Glucose', 'Glycogen-accumulated-Glucose', 'Glycosaminoglycans-determined-Disaccharides', 'Doxorubicin-augment-Glucose', 'Acarbose-treated-Glucose', 'Enoxaparin-appear-Heparin', 'Polysaccharides-associated-Glycogen', 'Glycogen-associated-Polysaccharides', 'Glycogen-play-Polysaccharides', 'Glycogen-proposed-Polysaccharides', 'Glucose-attached-Heptoses', 'Glucose-attached-Galactose', 'Oligosaccharides-contain-Glucose', 'Heptoses-attached-Galactose', 'Oligosaccharides-attached-Heptoses', 'Ascorbic Acid-used-Anthocyanins', 'Glucose-seen-Sucrose', 'Glucose-extend-Glucosamine', 'Glycosaminoglycans-reflect-Hyaluronic Acid', 'Canagliflozin-associated-Glucose', 'Glucose-associated-Canagliflozin', 'Heparin-included-Heparin, Low-Molecular-Weight', 'Fondaparinux-included-Heparin, Low-Molecular-Weight', 'Chondroitin Sulfates-find-Glycosaminoglycans', 'Dermatan Sulfate-find-Glycosaminoglycans', 'Chondroitin Sulfates-correlate-Glycosaminoglycans', 'Glucose-replace-Fructose', 'Glycosaminoglycans-interact-Heparin', 'Sialic Acids-substitute-Neuraminic Acids', 'Neuraminic Acids-found-Polysaccharides', 'Sucralfate-reduce-Digoxin', 'Acarbose-reduce-Digoxin', 'Heparin-replaced-Nadroparin', 'Sialic Acids-link-Galactose', 'Fructose-participate-Glucose', 'Fondaparinux-characterized-Heparin, Low-Molecular-Weight', 'Heparin, Low-Molecular-Weight-given-Fondaparinux', 'N-Acetylneuraminic Acid-bear-Oligosaccharides', 'Glucose-follow-Fructose', 'Sucrose-follow-Fructose', 'Sucrose-reduce-Glucose', 'Polysaccharides-bear-Acetylglucosamine', 'Fructosamine-demonstrate-Glucose', 'Glucosamine-follow-Glycosaminoglycans', 'Blood Glucose-use-Glucose', 'Sugars-classified-Mannose', 'Sugars-enable-Mannose', 'Sugars-release-Oligosaccharides', 'Heparin-excreted-Heparin, Low-Molecular-Weight', 'N-Acetylneuraminic Acid-incorporate-Sugars', 'Sugars-incorporate-N-Acetylneuraminic Acid', 'Sepharose-treated-Anthracyclines', 'Glucose-involved-Glycogen', 'Heparin, Low-Molecular-Weight-prove-Heparin', 'Glucose-reduce-Deoxyglucose', 'Glucose-reduce-Sugars', 'Heparin-show-Heparin, Low-Molecular-Weight', 'N-Acetylneuraminic Acid-inhale-Zanamivir', 'Glycosaminoglycans-include-Chondroitin Sulfates', 'Heparitin Sulfate-interact-Oligosaccharides', 'Idarubicin-treated-Etoposide', 'Glycosaminoglycans-use-Hyaluronic Acid', 'Glycosaminoglycans-determine-Chondroitin Sulfates', 'Disaccharides-separated-Heparin', 'Disaccharides-exist-Heparin', 'Ascorbic Acid-oxidize-Glucose', 'Fructosamine-compare-Glucose', 'Glucose-induce-Fructose', 'Oligosaccharides-vary-Fucose', 'Monosaccharides-derived-Lactose', 'Fucose-vary-N-Acetylneuraminic Acid', 'Lactose-analyzed-N-Acetylneuraminic Acid', 'N-Acetylneuraminic Acid-decrease-Fucose', 'Chondroitin Sulfates-appear-Keratan Sulfate', 'Dermatan Sulfate-indicate-Glycosaminoglycans', 'Ouabain-eliminate-Glycosides', 'Amikacin-used-Clindamycin', 'Dietary Fiber-normalize-Glucose', 'Keratan Sulfate-contain-Chondroitin Sulfates', 'Keratan Sulfate-contain-Dermatan Sulfate', 'Glycosaminoglycans-reveal-Hyaluronic Acid', 'Glycosaminoglycans-reveal-Heparitin Sulfate', 'Glycosaminoglycans-remain-Chondroitin Sulfates', 'Glycosaminoglycans-remain-Dermatan Sulfate', 'Glycosaminoglycans-remain-Heparitin Sulfate', 'Heparitin Sulfate-analysed-Disaccharides', 'Heparitin Sulfate-consist-Disaccharides', 'Glucose-seen-Fructosamine', 'Glycosaminoglycans-measure-Hyaluronic Acid', 'Glycosaminoglycans-measure-Heparitin Sulfate', 'Glycosaminoglycans-measure-Chondroitin Sulfates', 'Metrizamide-found-Oligosaccharides', 'Fluorodeoxyglucose F18-measure-Glucose', 'Ascorbic Acid-undergo-Glucose', 'Glucose-replaced-Fructose', 'Glucose-used-Fluorodeoxyglucose F18', 'Hexosamines-identify-Glycosaminoglycans', 'Glucuronides-follow-Glucuronic Acid', 'Glycosphingolipids-achieve-Sphingolipids', 'Fatty Acids, Unsaturated-include-Fatty Acids', 'Phospholipids-include-Fatty Acids', 'Fatty Acids-accumulate-Docosahexaenoic Acids', 'Fats-shift-Oils', 'Docosahexaenoic Acids-deposited-Fatty Acids', 'Fatty Acids, Omega-3-concentrated-Fish Oils', 'Fatty Acids, Unsaturated-derived-alpha-Linolenic Acid', 'Docosahexaenoic Acids-derived-Linoleic Acid', 'Docosahexaenoic Acids-derived-alpha-Linolenic Acid', 'Oleic Acid-added-Palmitates', 'Fatty Acids, Monounsaturated-added-Palmitates', 'Ceramides-catalyze-Fatty Acids, Nonesterified', 'Calcitriol-induced-Palmitic Acid', 'Triglycerides-show-Cholesterol', 'Cholecalciferol-synthesized-Cholesterol', 'Cholecalciferol-act-Cholesterol', 'Epoprostenol-released-Dinoprostone', 'Prostaglandins-released-Epoprostenol', 'Prostaglandins-released-Dinoprostone', 'Palmitic Acid-reported-Fatty Acids, Nonesterified', 'Sphingolipids-generate-Ceramides', 'Phospholipids-compare-Fatty Acids', 'Phospholipids-compare-Fatty Acids, Omega-6', 'Eicosanoids-follow-Arachidonic Acid', 'Fatty Acids, Nonesterified-originate-Triglycerides', 'Fatty Acids, Nonesterified-named-Triglycerides', 'Fatty Acids-increase-Palmitates', 'Palmitates-increase-Fatty Acids, Unsaturated', 'Fatty Acids, Omega-3-interact-Linoleic Acid', 'Fatty Acids, Omega-6-interact-Linoleic Acid', 'Cholesterol-lead-Calcitriol', 'Fatty Acids-contain-Triglycerides', 'Fatty Acids-include-Oleic Acid', 'Glycosphingolipids-recognized-Gangliosides', 'Glycosphingolipids-recognized-Globosides', 'Gangliosides-recognized-Globosides', 'Cholesterol-quantified-Cholesterol Esters', 'Phosphatidylcholines-expand-Lysophosphatidylcholines', 'Fish Oils-stimulate-Fatty Acids', 'Palm Oil-obtained-Oils', 'Eicosapentaenoic Acid-included-Fatty Acids, Omega-3', 'Docosahexaenoic Acids-included-Fatty Acids, Omega-3', 'Fatty Acids, Omega-3-found-Fish Oils', 'Phospholipids-result-Phosphatidylserines', 'Rapeseed Oil-result-Fatty Acids', 'Rapeseed Oil-increase-Fatty Acids', 'Fatty Acids, Omega-3-yield-Triglycerides', 'Oxylipins-derived-Linoleic Acid', 'Cholesterol-known-Phospholipids', 'Dinoprostone-stimulate-Arachidonic Acid', 'Oxylipins-derived-Fatty Acids', 'Docosahexaenoic Acids-form-Oxylipins', 'Phosphatidylethanolamines-contain-Docosahexaenoic Acids', 'Fatty Acids-correlate-Triglycerides', 'Triglycerides-receive-Fatty Acids, Omega-3', 'Eicosapentaenoic Acid-measured-Fatty Acids', 'Docosahexaenoic Acids-measured-Fatty Acids', 'Eicosapentaenoic Acid-found-Fish Oils', 'Docosahexaenoic Acids-found-Fish Oils', 'Phytosterols-reported-Cholesterol', 'Phytosterols-reported-Margarine', 'Phytosterols-enriched-Margarine', 'Cholesterol-enriched-Margarine', 'Glycerophospholipids-show-Fatty Acids, Unsaturated', 'Fatty Acids-induced-Docosahexaenoic Acids', 'Fatty Acids-induced-Phospholipids', 'Triglycerides-correlate-Cholesterol', 'Glycosphingolipids-expressed-G(M1) Ganglioside', 'Phospholipids-assessed-Fish Oils', 'Phospholipids-contain-Arachidonic Acid', 'Cholesterol Esters-followed-Cholesterol', 'Triglycerides-followed-Cholesterol', 'Ceramides-followed-Cholesterol', 'Phospholipids-followed-Cholesterol', 'Sphingomyelins-followed-Cholesterol', 'Triglycerides-include-Cholesterol', 'Sterols-recognized-Cholesterol', 'Docosahexaenoic Acids-correlated-Eicosapentaenoic Acid', 'Phospholipids-used-Glycerophospholipids', 'alpha-Linolenic Acid-converted-Eicosapentaenoic Acid', 'alpha-Linolenic Acid-converted-Docosahexaenoic Acids', 'Linoleic Acid-include-alpha-Linolenic Acid', 'Linoleic Acid-include-Eicosapentaenoic Acid', 'Linoleic Acid-include-Docosahexaenoic Acids', 'Cholesterol-increase-Sphingomyelins', 'Fatty Acids-contain-Sterols', 'Cholesterol-contain-Trans Fatty Acids', 'Fatty Acids-inhibit-Phospholipids', 'Oils-hydrolyse-Triglycerides', 'Oils-accumulate-Fatty Acids', 'Oils-accumulate-Monoglycerides', 'Triglycerides-hydrolyse-Fatty Acids', 'Triglycerides-hydrolyse-Monoglycerides', 'Triglycerides-decreased-Cholesterol', 'Phosphatidylserines-measured-Cholesterol', 'Phosphatidylserines-measured-Phospholipids', 'Phospholipids-require-Docosahexaenoic Acids', 'Arachidonic Acid-fail-Docosahexaenoic Acids', 'Arachidonic Acid-reproduce-Docosahexaenoic Acids', 'Prostaglandins-impair-Arachidonic Acid', 'Prostaglandins-inhibit-Epoprostenol', 'Prostaglandins-inhibit-Thromboxanes', 'Triglycerides-elevate-Cholesterol Esters', 'Sphingolipids-show-Ceramides', 'Sphingolipids-show-Glucosylceramides', 'Sphingolipids-show-Sphingomyelins', 'Sphingolipids-show-Gangliosides', 'Cholesterol-augmented-Fatty Acids', 'Docosahexaenoic Acids-concentrated-Phospholipids', 'Glycosphingolipids-increase-Gangliosides', 'Triglycerides-measured-Cholesterol', 'Ceramides-generate-Fatty Acids', 'Ceramides-implicated-Fatty Acids', 'Glycerophospholipids-enriched-Docosahexaenoic Acids', 'Glycerophospholipids-enriched-Fatty Acids', 'Oils, Volatile-identified-Eucalyptol', 'Cholesterol-increased-Fatty Acids, Nonesterified', 'Eicosapentaenoic Acid-combined-Docosahexaenoic Acids', 'Eicosapentaenoic Acid-include-Fatty Acids, Unsaturated', 'Docosahexaenoic Acids-include-Fatty Acids, Unsaturated', 'Fatty Acids-incorporated-Triglycerides', 'Docosahexaenoic Acids-retain-Phospholipids', 'Docosahexaenoic Acids-conserve-Fatty Acids', 'Fatty Acids, Omega-3-retain-Phospholipids', 'Docosahexaenoic Acids-altered-Fatty Acids, Omega-3', 'Docosahexaenoic Acids-altered-Fatty Acids, Unsaturated', 'Prostaglandins-appear-Epoprostenol', 'Fatty Acids-esterified-Cholesterol', 'Cholesterol-esterified-Linoleic Acid', 'Fatty Acids-originate-Trans Fatty Acids', 'Isoprostanes-biosynthesized-Arachidonic Acid', 'Arachidonic Acid-include-Fatty Acids, Unsaturated', 'Phospholipids-required-Phosphatidylserines', 'Fatty Acids, Unsaturated-transform-Lipid Peroxides', 'Fatty Acids, Unsaturated-polyunsaturated-Lipid Peroxides', 'Isoprostanes-produced-Arachidonic Acid', 'Prostaglandins-produced-Arachidonic Acid', 'Isoprostanes-include-Prostaglandin H2', 'Docosahexaenoic Acids-termed-Neuroprostanes', 'Fatty Acids, Unsaturated-termed-Neuroprostanes', 'alpha-Linolenic Acid-promote-Eicosapentaenoic Acid', 'Fatty Acids-promote-Eicosapentaenoic Acid', 'alpha-Linolenic Acid-maintain-Docosahexaenoic Acids', 'Eicosapentaenoic Acid-maintain-Docosahexaenoic Acids', 'Phospholipids-accumulate-Lipid Bilayers', 'Triglycerides-determined-Cholesterol', 'Triglycerides-recommend-Cholesterol', 'Fatty Acids-enrich-alpha-Linolenic Acid', 'Fatty Acids, Omega-3-enrich-alpha-Linolenic Acid', 'Fatty Acids, Unsaturated-transform-Fatty Acids', 'Oils-carry-Trans Fatty Acids', 'Glycerides-facilitate-Fatty Acids, Nonesterified', 'Linoleic Acid-involved-Fatty Acids', 'Oleic Acid-involved-Fatty Acids', 'Atorvastatin-decrease-Cholesterol', 'Sphingolipids-contain-Fatty Acids', 'Thromboxane A2-stimulated-Arachidonic Acid', 'Fatty Acids, Omega-3-elicited-Eicosanoids', 'Ceramides-channeled-Glycosphingolipids', 'Ceramides-channeled-Gangliosides', 'Glycosphingolipids-increased-Sphingomyelins', 'Oils-melt-Triglycerides', 'G(M1) Ganglioside-facilitated-Cholesterol', 'Diglycerides-protect-Ceramides', 'Prostaglandins-inhibit-Dinoprostone', 'Docosahexaenoic Acids-taken-Fatty Acids', 'Lipofuscin-cause-Fatty Acids', 'Cholesterol-receive-Fluvastatin', 'Cholesterol-decrease-Fluvastatin', 'Fluvastatin-decrease-Triglycerides', 'Cholesterol-used-Atorvastatin', 'Atorvastatin-lower-Triglycerides', 'Atorvastatin-show-Cholesterol', 'Atorvastatin-show-Triglycerides', 'Atorvastatin-preferred-Triglycerides', 'Cholesterol-lower-Triglycerides', 'Fatty Acids, Omega-3-fed-Fish Oils', 'Cholesterol Esters-shown-Cholesterol', 'Cholesterol Esters-shown-Triglycerides', 'Cholesterol-estimated-Triglycerides', 'Leukotriene B4-mimicked-Lipoxins', 'Triglycerides-follow-Oleic Acid', 'Cholesterol-increased-Triglycerides', 'Phosphatidylcholines-associated-Phospholipids', 'Phospholipids-associated-Phosphatidylcholines', 'Cholesterol-include-Ceramides', 'Cholesterol-serve-Triglycerides', 'Linoleic Acid-incorporated-Phospholipids', 'Prostaglandins-investigated-Arachidonic Acid', 'Fatty Acids, Essential-derived-Linoleic Acid', 'Fatty Acids, Essential-derived-alpha-Linolenic Acid', 'Thromboxane A2-receive-Alprostadil', 'Fatty Acids, Unsaturated-derived-Linoleic Acid', 'Cholesterol Esters-replace-Dolichols', '6-Ketoprostaglandin F1 alpha-increased-Alprostadil', 'Oleic Acid-associated-Cholesterol', 'Cholesterol-associated-Oleic Acid', 'Cholesterol Esters-associated-Cholesterol', 'Cholesterol-associated-Cholesterol Esters', 'Phospholipids-determined-Phosphatidylserines', 'Phospholipids-implicated-Phosphatidylserines', 'Phosphatidylcholines-increase-Sphingomyelins', 'Glycolipids-identified-G(M1) Ganglioside', 'Sphingomyelins-increase-Cholesterol', 'Gangliosides-identified-G(M1) Ganglioside', 'Triglycerides-drawn-Cholesterol', 'Fatty Acids-affect-Sphingolipids', 'Phosphatidylcholines-replace-Docosahexaenoic Acids', 'Fish Oils-influence-Eicosanoids', 'Cholesterol-decrease-Fish Oils', 'Cholesterol-observed-Triglycerides', 'Fatty Acids, Monounsaturated-decrease-Linoleic Acid', 'Fatty Acids, Monounsaturated-decrease-Arachidonic Acid', 'Fatty Acids, Monounsaturated-decrease-Phospholipids', 'Triglycerides-used-Gemfibrozil', 'Gangliosides-migrate-G(M1) Ganglioside', 'Margarine-penetrate-Cholecalciferol', 'Glycosphingolipids-change-Ceramides', 'Cholesterol-reduced-Triglycerides', 'Prostaglandins-studied-Arachidonic Acid', 'Epoprostenol-drop-Arachidonic Acids', 'Fatty Acids-convert-Prostaglandins', '6-Ketoprostaglandin F1 alpha-reflect-Epoprostenol', '6-Ketoprostaglandin F1 alpha-constitute-Prostaglandins', '6-Ketoprostaglandin F1 alpha-constitute-Epoprostenol', 'Oils-hydrogenate-Trans Fatty Acids', 'Fatty Acids-occur-Cerebrosides', 'Fatty Acids-occur-Sulfoglycosphingolipids', 'Fatty Acids-occur-Sphingomyelins', 'Glycerophospholipids-show-Fatty Acids', 'Phospholipids-contain-Fatty Acids, Unsaturated', 'Phosphatidylinositols-characterized-Arachidonic Acid', 'Fatty Acids-characterized-Arachidonic Acid', 'Glutathione Disulfide-measured-Glutathione', 'Glutathione Disulfide-oxidise-Glutathione', 'Glutathione Disulfide-reduce-Glutathione', 'Glutathione Disulfide-measure-Glutathione', 'Glutathione Disulfide-include-Glutathione', 'Enalapril-use-Enalaprilat', 'Lisinopril-given-Enalapril', 'Aflatoxins-found-Aflatoxin B1', 'rs2295080-associate-rs11121704', 'rs11121704-associate-rs2295080', 'rs2295080-associate-rs1057079', 'rs1057079-associate-rs2295080', 'rs2295080-associate-rs73105013', 'rs73105013-associate-rs2295080', 'rs2295080-associate-rs573775', 'rs573775-associate-rs2295080', 'rs11121704-associate-rs1057079', 'rs1057079-associate-rs11121704', 'rs11121704-associate-rs73105013', 'rs73105013-associate-rs11121704', 'rs11121704-associate-rs573775', 'rs573775-associate-rs11121704', 'rs1057079-associate-rs73105013', 'rs73105013-associate-rs1057079', 'rs1057079-associate-rs573775', 'rs573775-associate-rs1057079', 'rs73105013-associate-rs573775', 'rs573775-associate-rs73105013', 'rs1805126-associated-rs6599230', 'rs6599230-associated-rs1805126', 'rs10505348-associated-rs2073618', 'rs2073618-associated-rs10505348', 'rs13217795-associated-rs12206094', 'rs12206094-associated-rs13217795', 'rs13217795-associated-rs13220810', 'rs13220810-associated-rs13217795', 'rs13217795-associated-rs7762395', 'rs7762395-associated-rs13217795', 'rs13217795-associated-rs9486902', 'rs9486902-associated-rs13217795', 'rs2764264-associated-rs12206094', 'rs12206094-associated-rs2764264', 'rs2764264-associated-rs13220810', 'rs13220810-associated-rs2764264', 'rs2764264-associated-rs7762395', 'rs7762395-associated-rs2764264', 'rs2764264-associated-rs9486902', 'rs9486902-associated-rs2764264', 'rs479744-associated-rs12206094', 'rs12206094-associated-rs479744', 'rs479744-associated-rs13220810', 'rs13220810-associated-rs479744', 'rs479744-associated-rs7762395', 'rs7762395-associated-rs479744', 'rs479744-associated-rs9486902', 'rs9486902-associated-rs479744', 'rs9400239-associated-rs12206094', 'rs12206094-associated-rs9400239', 'rs9400239-associated-rs13220810', 'rs13220810-associated-rs9400239', 'rs9400239-associated-rs7762395', 'rs7762395-associated-rs9400239', 'rs9400239-associated-rs9486902', 'rs9486902-associated-rs9400239', 'rs72552732-increase-rs774792831', 'rs63750526-compare-rs63750264', 'Neoplasms-receive-Heart Arrest', 'Marfan Syndrome-associated-Neoplasms', 'Neoplasms-associated-Marfan Syndrome', 'Marfan Syndrome-associated-Neoplasm Metastasis', 'Neoplasm Metastasis-associated-Marfan Syndrome', 'Hip Fractures-complicated-Hypertension', 'Hip Fractures-complicated-Stroke', 'Hip Fractures-complicated-Diabetes Mellitus', 'Hip Fractures-complicated-Hypoproteinemia', 'Hip Fractures-complicated-Anemia', 'Hip Fractures-complicated-Venous Thrombosis', 'Hip Fractures-complicated-Pneumonia', 'Pain-influence-Headache Disorders, Secondary', 'Cardiomyopathy, Hypertrophic-accompanied-Heart Failure, Diastolic', 'Stroke-caused-Rupture', 'Cerebrovascular Disorders-caused-Rupture', 'Ovarian Diseases-provide-Ovarian Neoplasms', 'Vasculitis-cause-Inflammation', 'Autoimmune Diseases-cause-Inflammation', 'Vasculitis-classified-Giant Cell Arteritis', 'Vasculitis-classified-Aortic Arch Syndromes', 'Headache Disorders, Secondary-develop-Lymphoma, Non-Hodgkin', 'Nervous System Diseases-develop-Lymphoma, Non-Hodgkin', 'Cardiomyopathy, Hypertrophic-described-Syncope', 'Cardiomyopathy, Hypertrophic-present-Syncope', 'Cardiomyopathy, Hypertrophic-described-Death, Sudden, Cardiac', 'Cardiomyopathy, Hypertrophic-present-Death, Sudden, Cardiac', 'Chediak-Higashi Syndrome-undergo-Osteoporotic Fractures', 'Osteoporotic Fractures-undergo-Fatigue', 'Fever-experience-Central Nervous System Diseases', 'Signs and Symptoms, Respiratory-experience-Central Nervous System Diseases', 'Neoplasms-investigate-Nervous System Diseases', 'Neoplasms-associated-Plaque, Amyloid', 'Plaque, Amyloid-associated-Neoplasms', 'Neoplasms-associated-Cerebral Amyloid Angiopathy', 'Cerebral Amyloid Angiopathy-associated-Neoplasms', 'Death-experience-Neoplasms', 'Wounds and Injuries-include-Disease', 'Polyuria-include-Disease', 'Pituitary Diseases-include-Disease', 'Stroke-become-Nervous System Diseases', 'Cataract-reported-Hyperglycemia', 'Cataract-observed-Diabetes Mellitus', 'Neoplasms-assess-Sarcopenia', 'Sarcopenia-detected-Osteoporosis', 'Diabetes Mellitus-indicate-Kidney Diseases', 'Atherosclerosis-indicate-Kidney Diseases', 'Sleep Wake Disorders-clarify-Adrenal Insufficiency', 'Parkinson Disease-clarify-Adrenal Insufficiency', 'Erythema-cause-Skin Diseases', 'Vision Disorders-clarify-Adrenal Insufficiency', 'Psychoses, Substance-Induced-clarify-Adrenal Insufficiency', 'Muscular Atrophy-include-Sarcopenia', 'Hallucinations-consist-Psychoses, Substance-Induced', 'Psychoses, Substance-Induced-consist-Hallucinations', 'Muscular Disorders, Atrophic-characterized-Keratosis', 'Muscular Disorders, Atrophic-characterized-Pigmentation Disorders', 'Keratosis-characterized-Hypertrophy', 'Hypertrophy-characterized-Pigmentation Disorders', 'Prediabetic State-associated-Death', 'Death-associated-Prediabetic State', 'Mitral Valve Insufficiency-arise-Heart Failure', 'Aortic Valve Insufficiency-associated-Hypertension', 'Hypertension-associated-Aortic Valve Insufficiency', 'Lymphopenia-associated-Infections', 'Infections-associated-Lymphopenia', 'Osteoarthritis-thought-Joint Diseases', 'Alzheimer Disease-result-Dementia', 'Neoplasms-perceived-Communicable Diseases', 'Hip Fractures-accompanied-Craniocerebral Trauma', 'Death-associated-Dysautonomia, Familial', 'Dysautonomia, Familial-associated-Death', 'Cardiomyopathies-associated-Dysautonomia, Familial', 'Dysautonomia, Familial-associated-Cardiomyopathies', 'Neoplasms-avoid-Drug-Related Side Effects and Adverse Reactions', 'Arrhythmias, Cardiac-range-Neoplasms', 'Heart Failure-range-Neoplasms', 'Cardiovascular Diseases-limit-Neoplasms', 'Fibrosis-initiated-Mitochondrial Diseases', 'Fibrosis-lead-Inflammation', 'Mitochondrial Diseases-lead-Inflammation', 'Bacterial Infections-accompanied-Leukopenia', 'Abdominal Pain-treat-Hypertension', 'Constipation-treat-Hypertension', 'Death-show-Hypertension', 'Death-show-Diabetes Mellitus', 'Hypertension-show-Diabetes Mellitus', 'Hypertension-need-Diabetes Mellitus', 'Bundle-Branch Block-used-Pain', 'Joint Diseases-used-Pain', 'Aneurysm-include-Hypoxia-Ischemia, Brain', 'Addison Disease-occur-Neoplasms', 'Klatskin Tumor-caused-Cholangiocarcinoma', 'Klatskin Tumor-caused-Gallbladder Neoplasms', 'Klatskin Tumor-caused-Neoplasms', 'Biliary Dyskinesia-caused-Cholangiocarcinoma', 'Biliary Dyskinesia-caused-Gallbladder Neoplasms', 'Biliary Dyskinesia-caused-Neoplasms', 'Communicable Diseases-suffer-Respiratory Tract Infections', 'Hypertension-associated-Hemorrhage', 'Hemorrhage-associated-Hypertension', 'Metabolic Diseases-exacerbated-Obesity', 'Metabolic Diseases-exacerbated-Diabetes Mellitus', 'Abnormalities, Drug-Induced-include-Dementia', 'Abnormalities, Drug-Induced-lack-Dementia', 'Alzheimer Disease-lead-Memory Disorders', 'Alzheimer Disease-lead-Death', 'Brain Injury, Chronic-lead-Memory Disorders', 'Brain Injury, Chronic-lead-Death', 'Brain Injury, Chronic-lead-Dementia', 'Alzheimer Disease-contribute-Mitochondrial Diseases', 'Mitochondrial Diseases-resemble-Alzheimer Disease', 'Dementia-recognized-Diabetes Mellitus, Type 2', 'Venous Thrombosis-cause-Diabetic Angiopathies', 'Venous Thrombosis-put-Sepsis', 'Heart Failure-describe-Heart Diseases', 'Heart Failure-describe-Hypotension', 'Hypotension-include-Heart Diseases', 'Cardiomyopathies-impacted-Diabetes Mellitus', 'Cardiomyopathies-impacted-Obesity', 'Death-compared-Osteoarthritis', 'Dementia, Vascular-accompany-Alzheimer Disease', 'Kidney Calculi-ascend-Urolithiasis', 'Heart Failure-suffer-Cardiomyopathies', 'Thromboembolism-suffer-Cardiomyopathies', 'Arrhythmias, Cardiac-suffer-Cardiomyopathies', 'Weight Loss-decrease-Stomach Neoplasms', 'Muscular Diseases-decrease-Stomach Neoplasms', 'Pneumonia-decrease-Stomach Neoplasms', 'Pneumonia-diagnosed-Stomach Neoplasms', 'Sarcopenia-develop-Pain, Postoperative', 'Sarcopenia-associated-Pain, Postoperative', 'Pain, Postoperative-associated-Sarcopenia', 'Sarcopenia-associated-Stomach Neoplasms', 'Stomach Neoplasms-associated-Sarcopenia', 'Sarcopenia-undergo-Stomach Neoplasms', 'Pain, Postoperative-undergo-Stomach Neoplasms', 'Infections-lead-Brain Damage, Chronic', 'Ketosis-compare-Obesity', 'Ketosis-induced-Obesity', 'Weight Loss-compare-Obesity', 'Weight Loss-modulate-Obesity', 'Ketosis-induced-Weight Loss', 'Ketosis-induced-Infections', 'Ketosis-prevent-Infections', 'Neoplasms-live-Dementia', 'Ketosis-induced-Carcinogenesis', 'Ketosis-prevent-Carcinogenesis', 'Multiple Organ Failure-reduce-Drug-Related Side Effects and Adverse Reactions', 'Respiratory Tract Diseases-shortened-Neurologic Manifestations', 'Colorectal Neoplasms-estimated-Death', 'Colorectal Neoplasms-result-Death', 'Coronary Artery Disease-listed-Death', 'Cerebrovascular Disorders-listed-Death', 'Joint Diseases-indicate-Pain', 'Pain-improve-Joint Diseases', 'Joint Diseases-follow-Pain', 'Diabetes Mellitus-identify-Dementia', 'Amyloidosis-remain-Diabetes Mellitus', 'Neurodegenerative Diseases-used-Dementia', 'Sleep Wake Disorders-impact-Heredodegenerative Disorders, Nervous System', 'Neurodegenerative Diseases-remain-Diabetes Mellitus', 'Alzheimer Disease-remain-Diabetes Mellitus', 'REM Sleep Behavior Disorder-develop-Parkinson Disease', 'REM Sleep Behavior Disorder-develop-Dementia', 'Sleep Initiation and Maintenance Disorders-fall-Death', 'Cardiovascular Diseases-combined-Diabetes Mellitus', 'Cardiovascular Diseases-combined-Dyslipidemias', 'Skin Diseases-follow-Xerostomia', 'Skin Diseases-cause-Xerostomia', 'Movement Disorders-identify-Pain', 'Fractures, Open-associated-Fatigue', 'Fatigue-associated-Fractures, Open', 'Supranuclear Palsy, Progressive-include-Movement Disorders', 'Retinal Degeneration-include-Movement Disorders', 'Ovarian Diseases-opening-Infertility, Female', 'Bone Diseases, Metabolic-associated-Fractures, Bone', 'Fractures, Bone-associated-Bone Diseases, Metabolic', 'Osteoporotic Fractures-observed-Osteonecrosis', 'Osteoporosis-accompanied-Osteoporotic Fractures', 'Cardiovascular Diseases-suffer-Coronary Artery Disease', 'Cardiovascular Diseases-defined-Heart Failure', 'Cardiovascular Diseases-suffer-Heart Failure', 'Cardiovascular Diseases-defined-Angina Pectoris', 'Cardiovascular Diseases-suffer-Angina Pectoris', 'Cardiovascular Diseases-suffer-Myocardial Infarction', 'Heart Failure-include-Coronary Artery Disease', 'Cardiovascular Diseases-suffer-Diabetes Mellitus', 'Liver Diseases-include-Hepatitis, Autoimmune', 'Liver Diseases-include-Liver Cirrhosis, Biliary', 'Liver Diseases-include-Cholangitis, Sclerosing', 'Diabetes Mellitus, Type 2-impair-Bone Neoplasms', 'Nerve Degeneration-resist-Alzheimer Disease', 'Epilepsy-arise-Stroke', 'Epilepsy-arise-Brain Neoplasms', 'Drug Resistant Epilepsy-arise-Stroke', 'Drug Resistant Epilepsy-arise-Brain Neoplasms', 'Death-exacerbated-Hyperglycemia', 'Death-exacerbated-Diabetes Mellitus', 'Osteoporotic Fractures-regarded-Bone Diseases', 'Metabolic Syndrome-promote-Glucose Intolerance', 'Infections-increase-Neoplasms', 'Obesity-lead-Cardiovascular Diseases', 'Hypertension-lead-Cardiovascular Diseases', 'Dyslipidemias-lead-Cardiovascular Diseases', 'Sleep Deprivation-lead-Heart Diseases', 'Sleep Deprivation-lead-Arrhythmias, Cardiac', 'Sleep Deprivation-lead-Stroke', 'Pain-related-Back Pain', 'Pain-related-Arthritis', 'Kidney Diseases-start-Diabetic Nephropathies', 'Diabetic Nephropathies-diagnosed-Multiple Myeloma', 'Chronic Disease-lead-Kidney Diseases', 'Chronic Disease-lead-Renal Insufficiency, Chronic', 'Chronic Disease-lead-Cardiovascular Diseases', 'Chronic Disease-lead-Heart Failure', 'Cardiac Complexes, Premature-alleviate-Thrombophilia', 'Malnutrition-minimize-Chronic Disease', 'Fractures, Bone-mobilize-Pain', 'Fractures, Bone-develop-Arthritis', 'Cerebral Infarction-include-Cardiovascular Diseases', 'Hearing Loss-follow-Tinnitus', 'Inflammation-result-Sleep Disorders, Circadian Rhythm', 'Atrophy-associated-Neurodegenerative Diseases', 'Neurodegenerative Diseases-associated-Atrophy', 'Papilledema-damaged-Hearing Disorders', 'Death-follow-Arthritis, Rheumatoid', 'Hip Fractures-characterized-Confusion', 'Delirium-characterized-Confusion', 'Atrial Fibrillation-associate-Delirium', 'Delirium-associate-Atrial Fibrillation', 'Pulmonary Disease, Chronic Obstructive-associate-Delirium', 'Delirium-associate-Pulmonary Disease, Chronic Obstructive', 'Cleidocranial Dysplasia-considered-Alzheimer Disease', 'Respiratory Tract Diseases-observed-Infections', 'Ovarian Diseases-include-Ovarian Neoplasms', 'Polycystic Ovary Syndrome-include-Ovarian Diseases', 'Ovarian Diseases-include-Sex Cord-Gonadal Stromal Tumors', 'Dysbiosis-associated-Inflammatory Bowel Diseases', 'Inflammatory Bowel Diseases-associated-Dysbiosis', 'Cardiovascular Diseases-reduce-Death', 'Infections-stood-Death', 'Infections-warranted-Death', 'Neoplasms-based-Thoracic Outlet Syndrome', 'Neurologic Manifestations-promote-Sarcopenia', 'Neurologic Manifestations-promote-Muscle Weakness', 'Cartilage Diseases-relieve-Pain', 'Neurologic Manifestations-promote-Fatigue', 'Pancreatic Neoplasms-undergo-Parkinson Disease', 'Hypotension-impair-Cardiomyopathy, Dilated', 'Communicable Diseases-link-Arbovirus Infections', 'Signs and Symptoms, Respiratory-associated-Delirium', 'Delirium-associated-Signs and Symptoms, Respiratory', 'Signs and Symptoms, Respiratory-associated-Death', 'Death-associated-Signs and Symptoms, Respiratory', 'Pain-correlate-Diabetes Mellitus', 'Fatigue-used-Hypotension', 'Mitochondrial Diseases-linked-Alzheimer Disease', 'Abnormalities, Drug-Induced-reduce-Death', 'Anemia-assess-Chronic Disease', 'Chronic Disease-show-Anemia', 'Chronic Disease-show-Diabetes Mellitus', 'Chronic Disease-show-Hypertension', 'Chronic Disease-show-Hypercholesterolemia', 'Anemia-associated-Vision Disorders', 'Vision Disorders-associated-Anemia', 'Liver Cirrhosis-use-Liver Diseases', 'Inflammation-favor-Cardiovascular Diseases', 'Neurodegenerative Diseases-modeling-Brain Injuries, Traumatic', 'Musculoskeletal Diseases-focus-Renal Insufficiency, Chronic', 'Musculoskeletal Diseases-promote-Fractures, Bone', 'Renal Insufficiency, Chronic-promote-Fractures, Bone', 'Chronic Kidney Disease-Mineral and Bone Disorder-promote-Fractures, Bone', 'Immunologic Deficiency Syndromes-reflect-Alzheimer Disease', 'Immunologic Deficiency Syndromes-related-Alzheimer Disease', 'Alzheimer Disease-decrease-Arbovirus Infections', 'Vomiting-present-Erythema Nodosum', 'Abdominal Pain-present-Erythema Nodosum', 'Pain-induced-Distal Myopathies', 'Atherosclerosis-defined-Vascular Calcification', 'Obesity-act-Sarcopenia', 'Obesity, Abdominal-associated-Sarcopenia', 'Sarcopenia-associated-Obesity, Abdominal', 'Pulmonary Disease, Chronic Obstructive-include-Lung Diseases', 'Sleep Wake Disorders-include-Lung Diseases', 'Asthma-include-Lung Diseases', 'Hypertension, Pulmonary-include-Lung Diseases', 'Lung Diseases, Interstitial-include-Lung Diseases', 'Adrenocortical Hyperfunction-proposed-Neoplasms', 'Adrenocortical Hyperfunction-followed-Neurologic Manifestations', 'Heart Diseases-used-Drug-Related Side Effects and Adverse Reactions', 'Intracranial Hemorrhages-underlie-Cerebral Amyloid Angiopathy', 'Carotid Artery Diseases-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-Carotid Artery Diseases', 'Brain Neoplasms-increase-Death', 'Neoplasm Metastasis-increase-Death', 'Vision Disorders-function-Death', 'Fractures, Bone-compare-Wounds and Injuries', 'Fractures, Bone-compare-Osteoporosis', 'Fatigue-mediate-Sleep Initiation and Maintenance Disorders', 'Hypotension-seen-Long QT Syndrome', 'Drug-Related Side Effects and Adverse Reactions-underlie-Urinary Retention', 'Sarcopenia-defined-Muscular Diseases', 'Hyperglycemia-represent-Diabetes Mellitus', 'Pneumonia, Pneumocystis-diagnosed-Death', 'Headache-suggest-Perceptual Disorders', 'Invasive Pulmonary Aspergillosis-diagnosed-Death', 'Hearing Loss-result-Hereditary Central Nervous System Demyelinating Diseases', 'Hearing Disorders-result-Hereditary Central Nervous System Demyelinating Diseases', 'Neoplasms-used-Ovarian Neoplasms', 'Neoplasms-compare-Ovarian Neoplasms', 'Myotonic Dystrophy-remain-Chronic Disease', 'Sleep Wake Disorders-reduce-Alzheimer Disease', 'Anemia-predict-Death', 'Death-increase-Anemia', 'Anemia-identify-Death', 'Liver Failure-ameliorate-Dyslipidemias', 'Liver Failure-ameliorate-Hypotension', 'Hypertrophy-study-Aortic Valve Stenosis', 'Genetic Diseases, Inborn-result-Atherosclerosis', 'Muscle Hypotonia-fall-Cardiac Output, Low', 'Fractures, Bone-treat-Bone Diseases, Metabolic', 'Fractures, Bone-treat-Osteoporosis', 'Osteoporosis-incorporated-Osteoporotic Fractures', 'Osteoporosis-induced-Neoplasms', 'Unconsciousness-underlie-Alzheimer Disease', 'Blood Platelet Disorders-play-Hepatic Veno-Occlusive Disease', 'Muscular Dystrophy, Duchenne-perceived-Osteoporosis', 'Glycogen Storage Disease Type II-show-Diabetes Mellitus', 'Hypertension-decrease-Cardiovascular Diseases', 'Inflammation-cause-Muscular Diseases', 'Vision Disorders-identified-Dementia', 'Vision Disorders-prevented-Dementia', 'Vision Disorders-prevent-Dementia', 'Dementia-caused-Pain', 'Chronic Kidney Disease-Mineral and Bone Disorder-improve-Death', 'Neurologic Manifestations-result-Inflammation', 'Neurologic Manifestations-result-Fibrosis', 'Seizures-reduce-Cardiac Output, Low', 'Death-include-Intraabdominal Infections', 'Death-include-Sepsis', 'Death-include-Shock, Septic', 'Death-include-Liver Diseases', 'Death-include-Malnutrition', 'Inflammation-linked-Chronic Disease', 'Obesity-join-Weight Loss', 'Alzheimer Disease-found-Epilepsy', 'Epilepsy-share-Nerve Degeneration', 'Movement Disorders-accompanied-Immunologic Deficiency Syndromes', 'Epilepsy-share-Alzheimer Disease', 'Epilepsy, Temporal Lobe-share-Alzheimer Disease', 'Osteosarcoma-develop-Osteoma, Osteoid', 'Hyperkinesis-implicated-Huntington Disease', 'Neoplasms-discuss-Death', 'Atrial Fibrillation-constitute-Stroke', 'Stroke-exclude-Intracranial Hemorrhages', 'Stroke-exclude-Cardiovascular Diseases', 'Hypotension-use-Seizures', 'Obesity-represent-Sarcopenia', 'Sarcopenia-represent-Obesity', 'Urinary Incontinence-associated-Sarcopenia', 'Sarcopenia-associated-Urinary Incontinence', 'Urinary Incontinence-represent-Obesity', 'Astigmatism-treated-Corneal Diseases', 'Aneuploidy-delete-Neoplasms', 'Alzheimer Disease-combine-Inflammation', 'Alzheimer Disease-combine-Neurodegenerative Diseases', 'Inflammation-involved-Dementia', 'Venous Thromboembolism-affect-Wounds and Injuries', 'Diabetes Mellitus-induce-Obesity', 'Arthralgia-attributed-Lupus Erythematosus, Systemic', 'Myalgia-attributed-Lupus Erythematosus, Systemic', 'Fatigue-attributed-Lupus Erythematosus, Systemic', 'Lupus Erythematosus, Systemic-suspected-Polymyalgia Rheumatica', 'Inflammation-measured-Dementia', 'Sexual Dysfunction, Physiological-predict-Death', 'Infections-prevent-Pelvic Inflammatory Disease', 'Infections-prevent-Infertility, Female', 'Infections-caused-Gonorrhea', 'Neurologic Manifestations-play-Osteoarthritis', 'Neurologic Manifestations-play-Neurodegenerative Diseases', 'Hyperemia-assess-Parkinson Disease', 'Dysbiosis-seen-Stroke', 'Dysbiosis-seen-Obesity', 'Dysbiosis-seen-Diabetes Mellitus', 'Dysbiosis-seen-Atherosclerosis', 'Respiratory Insufficiency-associated-Death', 'Death-associated-Respiratory Insufficiency', 'Respiratory Insufficiency-found-Death', 'Hypertension-explore-Lupus Erythematosus, Systemic', 'Parkinsonian Disorders-use-Parkinson Disease', 'Hypokinesia-use-Parkinson Disease', 'Muscle Rigidity-use-Parkinson Disease', 'Tremor-use-Parkinson Disease', 'Arthritis-followed-Hypertension', 'Leukoencephalopathies-considered-Cerebrovascular Disorders', 'Inflammation-recognized-Joint Diseases', 'Inflammation-modify-Pain', 'Inflammation-modify-Osteoarthritis', 'Obesity-modify-Osteoarthritis', 'Brain Injuries, Traumatic-associated-Neurodegenerative Diseases', 'Neurodegenerative Diseases-associated-Brain Injuries, Traumatic', 'Hip Fractures-focus-Fractures, Bone', 'Osteoporosis-achieved-Muscular Dystrophy, Duchenne', 'Infections-limit-Chronic Disease', 'Hypertension-discussed-Blood Coagulation Disorders', 'Hypertension-discussed-Diabetes Mellitus', 'Hyperlipidemias-discussed-Blood Coagulation Disorders', 'Hyperlipidemias-discussed-Diabetes Mellitus', 'Cardiomegaly-initiated-Infarction', 'Constipation-elucidate-Adrenal Insufficiency', 'Diabetes Mellitus-include-Death', 'Cachexia-increase-Death', 'Cachexia-increase-Neoplasms', 'Inflammation-caused-Hypoxia', 'Infertility, Female-provide-Growth Disorders', 'Hemorrhage-cured-Endometrial Neoplasms', 'Myocardial Infarction-characterised-Thrombosis', 'Thrombosis-lead-Cardiomyopathies', 'Lymphoma-found-Neoplasms', 'Amyotrophic Lateral Sclerosis-result-Death', 'Liver Neoplasms-result-Death', 'Lymphopenia-follow-Neutropenia', 'HIV Infections-associated-Fatty Liver', 'Fatty Liver-associated-HIV Infections', 'HIV Infections-compare-Fatty Liver', 'Alzheimer Disease-base-Ventricular Fibrillation', 'Alzheimer Disease-propose-Ventricular Fibrillation', 'Diabetes Mellitus-prevent-Coronary Artery Disease', 'Infections-followed-Pneumonia', 'Pyelonephritis-followed-Pneumonia', 'Pyelonephritis-associated-Dementia', 'Dementia-associated-Pyelonephritis', 'Death-focused-Chronic Disease', 'Diabetes Mellitus-documented-Dementia', 'Wounds and Injuries-observe-Death', 'Malaria-impact-Tooth, Impacted', 'Brain Injuries, Traumatic-result-Neurodegenerative Diseases', 'Sarcopenia-related-Alzheimer Disease', 'Neurodegenerative Diseases-examine-Brain Injuries, Traumatic', 'Malnutrition-live-Sarcopenia', 'Skin Diseases-lead-Neoplasms', 'Dementia-identified-Delirium', 'Communicable Diseases-represented-Delirium', 'Stroke-associated-Infections', 'Infections-associated-Stroke', 'Stroke-show-Infections', 'Stroke-promote-Heart Arrest', 'Stroke-result-Infections', 'Sarcopenia-affect-Chronic Disease', 'Anemia-correlated-Sarcopenia', 'Malnutrition-correlated-Sarcopenia', 'Inflammation-correlated-Sarcopenia', 'Prostatic Hyperplasia-correlated-Inflammation', 'Sarcoma-include-Optic Nerve Neoplasms', 'Sarcoma-include-Glomus Tumor', 'Myotonic Dystrophy-compare-Subarachnoid Hemorrhage', 'Myotonic Dystrophy-compare-Death', 'Neoplasms-consist-Carcinoma, Hepatocellular', 'Myotonic Dystrophy-compare-Cardiovascular Diseases', 'Myotonic Dystrophy-compare-Diabetes Mellitus', 'Subarachnoid Hemorrhage-predict-Death', 'Lung Diseases-associate-Pneumonia', 'Pneumonia-associate-Lung Diseases', 'Pneumonia-develop-Infections', 'Death-entered-Inflammation', 'Inflammation-augmented-Arbovirus Infections', 'Cardiomyopathies-contribute-Neoplasms', 'Cardiotoxicity-follow-Neoplasms', 'Cardiotoxicity-emerge-Neoplasms', 'Osteoporotic Fractures-result-Dystonia', 'Osteoporotic Fractures-result-Cardiovascular Abnormalities', 'Esotropia-caused-Anophthalmos', 'Hip Fractures-divided-Femoral Neuropathy', 'Hip Fractures-receive-Femoral Neuropathy', 'Sarcoidosis-increase-Adenomatous Polyposis Coli', 'Death-increase-Adenomatous Polyposis Coli', 'Death-require-Sarcoidosis', 'Alzheimer Disease-protect-Neurodegenerative Diseases', 'Huntington Disease-protect-Neurodegenerative Diseases', 'Parkinson Disease-protect-Neurodegenerative Diseases', 'Hypertension-attributed-Neoplasms', 'Hypertension-include-Neoplasms', 'Hypertension-identify-Neoplasms', 'Disseminated Intravascular Coagulation-become-Aneurysm', 'Coronary Artery Disease-known-Cardiovascular Diseases', 'Adenomatous Polyposis Coli-associate-Hypertension', 'Hypertension-associate-Adenomatous Polyposis Coli', 'Adenomatous Polyposis Coli-associate-Obesity', 'Obesity-associate-Adenomatous Polyposis Coli', 'Liver Neoplasms-exist-Neurodegenerative Diseases', 'Adenomatous Polyposis Coli-associate-Glucose Intolerance', 'Glucose Intolerance-associate-Adenomatous Polyposis Coli', 'Neurodegenerative Diseases-focus-Alzheimer Disease', 'Immunologic Deficiency Syndromes-include-Malabsorption Syndromes', 'Multiple Organ Failure-related-Hypertension', 'Malabsorption Syndromes-distributed-Immunologic Deficiency Syndromes', 'Thoracic Outlet Syndrome-contribute-Intermittent Claudication', 'Cardiovascular Diseases-recommended-Hypertension', 'Immunologic Deficiency Syndromes-decrease-Death', 'Sarcopenia-diagnosed-Malnutrition', 'Inflammation-exacerbate-Communicable Diseases', 'Death-contract-Communicable Diseases', 'Alzheimer Disease-improve-Cardiovascular Diseases', 'Inflammation-considered-Alzheimer Disease', 'Neoplasms-double-Neurodegenerative Diseases', 'Neoplasms-trigger-Neurodegenerative Diseases', 'Neoplasms-trigger-Death', 'Neurodegenerative Diseases-trigger-Death', 'Alzheimer Disease-include-Cardiovascular Diseases', 'Xeroderma Pigmentosum-characterized-Skin Neoplasms', 'Genetic Diseases, Inborn-characterized-Skin Neoplasms', 'Neurodegenerative Diseases-originate-Nerve Degeneration', 'Nail-Patella Syndrome-explore-Alzheimer Disease', 'Nail-Patella Syndrome-represent-Alzheimer Disease', 'Genetic Diseases, Inborn-manifest-Fibrosis', 'Genetic Diseases, Inborn-manifest-Communicable Diseases', 'Cardiovascular Diseases-predispose-Ovarian Diseases', 'Hypertriglyceridemic Waist-predict-Cardiovascular Diseases', 'Neoplasms-find-Muscular Atrophy', 'Cachexia-occur-Neoplasms', 'Metabolic Syndrome-occur-Neoplasms', 'Cachexia-investigate-Lung Neoplasms', 'Cachexia-inject-Lung Neoplasms', 'Cachexia-investigate-Neoplasms', 'Lung Neoplasms-investigate-Neoplasms', 'Muscular Diseases-associated-Mitochondrial Diseases', 'Mitochondrial Diseases-associated-Muscular Diseases', 'Fibrosis-represent-Muscular Dystrophies', 'Fibrosis-occur-Wounds and Injuries', 'Fibrosis-occur-Macular Degeneration', 'Cardiomyopathies-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-Cardiomyopathies', 'Heart Diseases-induced-Diabetes Mellitus', 'Muscular Diseases-known-Cachexia', 'Neoplasms-cause-Muscular Diseases', 'Gastroparesis-associated-Death', 'Death-associated-Gastroparesis', 'Pain, Postoperative-include-Coronary Artery Disease', 'Atrial Fibrillation-include-Coronary Artery Disease', 'Arrhythmias, Cardiac-include-Coronary Artery Disease', 'Fractures, Bone-associated-Heart Failure', 'Heart Failure-associated-Fractures, Bone', 'Fractures, Bone-associated-Myocardial Infarction', 'Myocardial Infarction-associated-Fractures, Bone', 'Fractures, Bone-associated-Cerebrovascular Disorders', 'Cerebrovascular Disorders-associated-Fractures, Bone', 'Lactation Disorders-result-Fetal Alcohol Spectrum Disorders', 'Microcephaly-include-Hyperkinesis', 'Neurodegenerative Diseases-known-Tauopathies', 'Pelvic Neoplasms-represent-Death', 'Insulinoma-highlight-Delirium', 'Muscular Atrophy-occur-Prostatic Neoplasms', 'Prostatic Neoplasms-induce-Muscular Atrophy', 'Fatty Liver-affect-HIV Infections', 'HIV Infections-identify-Liver Cirrhosis', 'Fibrosis-develop-HIV Infections', 'Liver Cirrhosis-assess-HIV Infections', 'Death-combined-Heart Failure', 'Myocardial Infarction-combined-Heart Failure', 'Stroke-combined-Heart Failure', 'Headache-correlated-Vertigo', 'Migraine Disorders-associated-Vertigo', 'Vertigo-associated-Migraine Disorders', 'Myopia-associated-Vitreous Hemorrhage', 'Vitreous Hemorrhage-associated-Myopia', 'Atherosclerosis-take-Wounds and Injuries', 'Substance-Related Disorders-accompanied-Neurodegenerative Diseases', 'Sleepiness-follow-Fatigue', 'Adenoma-include-Muscular Dystrophy, Duchenne', 'Adenoma-include-Colorectal Neoplasms', 'Delirium-use-Death', 'Osteoporosis-associated-Adenoma', 'Adenoma-associated-Osteoporosis', 'Osteoporosis-associated-Colorectal Neoplasms', 'Colorectal Neoplasms-associated-Osteoporosis', 'Hyperphosphatemia-implicated-Death', 'Dementia-determined-Death', 'Cystic Fibrosis-associated-Neoplasms', 'Neoplasms-associated-Cystic Fibrosis', 'Paresis-admitted-Sleep Initiation and Maintenance Disorders', 'Neurodegenerative Diseases-impact-Alzheimer Disease', 'Diabetes Mellitus-show-Atrial Fibrillation', 'Deglutition Disorders-include-Neurologic Manifestations', 'Constipation-include-Neurologic Manifestations', 'Fecal Incontinence-include-Neurologic Manifestations', 'Liver Diseases-associated-Adrenoleukodystrophy', 'Adrenoleukodystrophy-associated-Liver Diseases', 'Liver Diseases-encompass-Carcinoma, Hepatocellular', 'Adrenoleukodystrophy-encompass-Carcinoma, Hepatocellular', 'Osteoarthritis-associated-Contracture', 'Contracture-associated-Osteoarthritis', 'Chronic Disease-associated-Hip Fractures', 'Hip Fractures-associated-Chronic Disease', 'Bone Diseases, Metabolic-prevent-Fractures, Bone', 'Obesity-characterized-Malabsorption Syndromes', 'Frailty-lead-Death', 'Hypertension-account-Chronic Disease', 'Diabetes Mellitus-account-Chronic Disease', 'Brain Injuries, Traumatic-include-Alzheimer Disease', 'Anemia-expressed-Gastrointestinal Hemorrhage', 'Ulcer-found-Hemorrhage', 'Glioma-enrolled-Neoplasms', 'Adenomatous Polyposis Coli-associated-Bone Malalignment', 'Bone Malalignment-associated-Adenomatous Polyposis Coli', 'Stroke-associated-Myotonic Dystrophy', 'Myotonic Dystrophy-associated-Stroke', 'Death-caused-Cardiovascular Diseases', 'Stroke-attenuate-Inflammation', 'Stroke-become-Neurodegenerative Diseases', 'Stroke-become-Brain Injuries, Traumatic', 'Neurodegenerative Diseases-related-Brain Injuries, Traumatic', 'Sarcopenia-lead-Dehydration', 'Sarcopenia-undergo-Parkinson Disease', 'Parkinson Disease-undergo-Sarcopenia', 'Multiple Organ Failure-carry-Death', 'Dementia-differ-Diabetes Mellitus', 'Peripheral Nervous System Diseases-associated-Dementia', 'Dementia-associated-Peripheral Nervous System Diseases', 'Sarcopenia-contribute-Inflammation', 'Inflammation-drive-Sarcopenia', 'Mitochondrial Diseases-induce-Lysosomal Storage Diseases', 'Lysosomal Storage Diseases-lead-Inflammation', 'Infections-provide-Hypoalphalipoproteinemias', 'Embolism, Fat-characterised-Respiratory Distress Syndrome', 'Embolism, Fat-characterised-Nervous System Diseases', 'Embolism, Fat-characterised-Exanthema', 'Death-investigate-Hearing Loss', 'Chemical and Drug Induced Liver Injury-direct-Liver Cirrhosis', 'Ventricular Fibrillation-compared-Arthritis, Rheumatoid', 'Osteoporosis-compared-Arthritis, Rheumatoid', 'Hypertrophy-observed-Ossification, Heterotopic', 'Obesity-defined-Disease', 'Cardiomegaly-result-Heart Failure', 'Cardiovascular Abnormalities-hyperphosphorylate-Alzheimer Disease', 'Dementia-exact-Alzheimer Disease', 'Ataxia-known-Machado-Joseph Disease', 'Neurodegenerative Diseases-associated-Amyotrophic Lateral Sclerosis', 'Amyotrophic Lateral Sclerosis-associated-Neurodegenerative Diseases', 'Dementia-associated-Deglutition Disorders', 'Deglutition Disorders-associated-Dementia', 'Neoplasms-report-Alzheimer Disease', 'Alzheimer Disease-experience-Neoplasms', 'Death-remain-Prostatic Neoplasms', 'Death-generate-Prostatic Neoplasms', 'Neoplasms-generate-Prostatic Neoplasms', 'Bone Diseases-associated-Inflammation', 'Inflammation-associated-Bone Diseases', 'Muscular Dystrophy, Duchenne-associated-Alveolar Bone Loss', 'Alveolar Bone Loss-associated-Muscular Dystrophy, Duchenne', 'Inflammation-play-Osteoporosis', 'Immunologic Deficiency Syndromes-mediate-Osteoporosis', 'Immunologic Deficiency Syndromes-impair-Inflammation', 'Osteoporosis-impair-Inflammation', 'Fractures, Bone-develop-Periodontitis', 'Periodontitis-impair-Inflammation', 'Fractures, Bone-undergo-Tooth Loss', 'Periodontitis-undergo-Tooth Loss', 'Chronic Disease-cause-Infections', 'Osteoporosis-treat-Periodontitis', 'Kidney Diseases-compare-HIV Infections', 'Kidney Diseases-suggest-HIV Infections', 'Pneumoconiosis-associated-Lung Neoplasms', 'Lung Neoplasms-associated-Pneumoconiosis', 'Pulmonary Alveolar Proteinosis-associated-Lung Neoplasms', 'Lung Neoplasms-associated-Pulmonary Alveolar Proteinosis', 'Hypertension-associated-Lung Neoplasms', 'Lung Neoplasms-associated-Hypertension', 'Stroke-associated-Lung Neoplasms', 'Lung Neoplasms-associated-Stroke', 'Coronary Artery Disease-associated-Lung Neoplasms', 'Lung Neoplasms-associated-Coronary Artery Disease', 'Osteoporosis-become-Fragile X Syndrome', 'Diabetes Mellitus-associated-Lung Neoplasms', 'Lung Neoplasms-associated-Diabetes Mellitus', 'Renal Insufficiency, Chronic-associated-Lung Neoplasms', 'Lung Neoplasms-associated-Renal Insufficiency, Chronic', 'Respiratory Tract Diseases-exhibit-Nervous System Diseases', 'Dementia-associated-Lung Neoplasms', 'Lung Neoplasms-associated-Dementia', 'Fibrosis-compare-Kidney Diseases', 'Glycogen Storage Disease Type II-cause-Wounds and Injuries', 'Glycogen Storage Disease Type II-seen-Macular Degeneration', 'Death-compare-Chronic Kidney Disease-Mineral and Bone Disorder', 'Hypothyroidism-increase-Metabolic Diseases', 'Chronic Disease-target-Dementia', 'Death-take-Osteoporosis', 'Hip Fractures-take-Osteoporosis', 'Fractures, Bone-take-Osteoporosis', 'Death-take-Neoplasms', 'Death-take-Hip Fractures', 'Alzheimer Disease-compensate-Nerve Degeneration', 'Death-take-Fractures, Bone', 'Death-take-Cardiovascular Diseases', 'Osteoporosis-take-Neoplasms', 'Osteoporosis-take-Hip Fractures', 'Osteoporosis-take-Fractures, Bone', 'Wasting Syndrome-caused-Muscular Dystrophy, Duchenne', 'Myelodysplastic Syndromes-characterized-Leukemia, Myeloid, Acute', 'Inflammation-highlight-Myelodysplastic Syndromes', 'Inflammation-highlight-Leukemia', 'Respiratory Tract Infections-include-Lung Diseases', 'Respiratory Tract Diseases-provoke-Airway Obstruction', 'Respiratory Insufficiency-include-Lung Diseases', 'Pleural Effusion-include-Lung Diseases', 'Respiratory Tract Diseases-induce-Hernias, Diaphragmatic, Congenital', 'Pneumothorax-include-Lung Diseases', 'Bronchial Spasm-include-Lung Diseases', 'Airway Obstruction-induce-Hernias, Diaphragmatic, Congenital', 'Myocardial Infarction-increase-Hypoxia', 'Polycystic Ovary Syndrome-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-Polycystic Ovary Syndrome', 'Polycystic Ovary Syndrome-associated-Death', 'Death-associated-Polycystic Ovary Syndrome', 'Respiratory Tract Infections-include-Communicable Diseases', 'Death-shift-Obesity', 'Asthma-show-Drug Hypersensitivity', 'Sarcopenia-characterized-Chronic Disease', 'Nervous System Diseases-improve-Alzheimer Disease', 'HIV Infections-experience-Acquired Immunodeficiency Syndrome', 'HIV Infections-include-Lung Diseases', 'HIV Infections-include-Neoplasms', 'HIV Infections--most-Neoplasms', 'Neurodegenerative Diseases-develop-Hemostatic Disorders', 'Death-increase-Parkinson Disease', 'Glycogen Storage Disease Type II-demonstrate-Cardiovascular Diseases', 'Choroiditis-considered-Glycogen Storage Disease Type II', 'Neurotoxicity Syndromes-govern-Memory Disorders', 'Death-interact-HIV Infections', 'Death-interact-Hypertension', 'Xerostomia-supported-Carcinoma, Acinar Cell', 'Xerostomia-supported-Fibrosis', 'Death-treat-Infections', 'Osteoporosis-known-Osteoporotic Fractures', 'Renal Insufficiency, Chronic-characterized-Renal Insufficiency', 'Renal Insufficiency, Chronic-characterized-Kidney Failure, Chronic', 'Chronic Kidney Disease-Mineral and Bone Disorder-characterized-Renal Insufficiency', 'Chronic Kidney Disease-Mineral and Bone Disorder-characterized-Kidney Failure, Chronic', 'Progeria-accumulate-Communicable Diseases', 'Neurologic Manifestations-associated-Neoplasms', 'Neoplasms-associated-Neurologic Manifestations', 'Neurologic Manifestations-associated-Obesity', 'Obesity-associated-Neurologic Manifestations', 'Neurologic Manifestations-associated-Infections', 'Infections-associated-Neurologic Manifestations', 'Inflammation-associated-Fanconi Anemia', 'Fanconi Anemia-associated-Inflammation', 'Cerebrovascular Disorders-place-Dementia', 'Tooth Loss-correlated-Cerebral Infarction', 'Tooth Loss-determine-Cerebral Infarction', 'Nerve Degeneration-ameliorate-Cerebral Infarction', 'Respiratory Insufficiency-show-Death', 'Respiratory Insufficiency-develop-Wounds and Injuries', 'Respiratory Insufficiency-related-Chest Pain', 'Osteoporosis-accelerate-Stroke', 'Bone Neoplasms-fall-Fractures, Bone', 'Headache Disorders, Secondary-defined-Headache', 'Xerostomia-linked-Inflammation', 'Xerostomia-linked-Hearing Loss, Central', 'Parkinson Disease-resect-Neoplasms', 'Parkinson Disease-undergo-Digestive System Neoplasms', 'Digestive System Neoplasms-undergo-Neoplasms', 'Communicable Diseases-remain-Tuberculosis', 'Communicable Diseases-remain-Malaria', 'HIV Infections-remain-AIDS Arteritis, Central Nervous System', 'HIV Infections-facilitate-Cerebrovascular Disorders', 'HIV Infections-follow-Atherosclerosis', 'HIV Infections-review-Atherosclerosis', 'HIV Infections-follow-Neurodegenerative Diseases', 'HIV Infections-review-Neurodegenerative Diseases', 'Cardiovascular Diseases-pose-Hemorrhage', 'Cardiovascular Diseases-pose-Hemophilia A', 'Cardiovascular Diseases-pose-Thrombosis', 'Death-appear-Atherosclerosis', 'Coronary Artery Disease-appear-Atherosclerosis', 'Atrial Fibrillation-predict-CHARGE Syndrome', 'Hypertension-observed-Aneurysm', 'Aneurysm-ruled-Intracranial Hemorrhages', 'Wounds and Injuries-include-Hemorrhage', 'Aneurysm-include-Hemorrhage', 'Blood Coagulation Disorders-include-Hemorrhage', 'Hypertension-followed-Hemorrhage', 'Hypertension-followed-Aneurysm', 'Alzheimer Disease-need-Dementia', 'Osteoporosis-become-Disorders of Sex Development', 'Vestibular Diseases-predict-Alzheimer Disease', 'Constipation-indexed-Parkinson Disease', 'REM Sleep Behavior Disorder-indexed-Parkinson Disease', 'Periodontal Diseases-linked-Atherosclerosis', 'Dysbiosis-linked-Atherosclerosis', 'Inflammation-regulate-Sarcopenia', 'Diabetes Mellitus-complicated-Fatty Liver', 'Heart Failure-affect-Cardiomyopathies', 'Heart Failure-affect-Cardiomyopathy, Hypertrophic', 'Heart Failure-affect-Takotsubo Cardiomyopathy', 'Heart Failure-affect-Heart Diseases', 'Heart Failure-affect-Sarcoidosis', 'Cardiomyopathies-include-Cardiomyopathy, Hypertrophic', 'Cardiomyopathies-include-Takotsubo Cardiomyopathy', 'Cardiomyopathies-include-Heart Diseases', 'Cardiomyopathies-include-Sarcoidosis', 'Inflammation-emerge-Infections', 'Arbovirus Infections-result-Respiratory Insufficiency', 'Arbovirus Infections-result-Respiratory Distress Syndrome', 'Arbovirus Infections-progress-Respiratory Distress Syndrome', 'Arbovirus Infections-result-Infections', 'Arbovirus Infections-result-Asthma', 'Arbovirus Infections-result-Diabetes Mellitus', 'Arbovirus Infections-result-Cardiovascular Diseases', 'Anemia, Sickle Cell-characterized-Hemolysis', 'Infections-result-Respiratory Insufficiency', 'Infections-cause-Respiratory Insufficiency', 'Hemolysis-characterized-Communicable Diseases', 'Infections-result-Respiratory Distress Syndrome', 'Infections-cause-Respiratory Distress Syndrome', 'Infections-result-Asthma', 'Infections-include-Asthma', 'Infections-include-Diabetes Mellitus', 'Infections-result-Cardiovascular Diseases', 'Ureteral Obstruction-employed-Fibrosis', 'Ureteral Obstruction-study-Fibrosis', 'Cataract-related-AIDS-Related Complex', 'Hypotrichosis-include-Hypertension', 'Diabetes Mellitus, Type 2-include-Hypertension', 'Diabetes Mellitus, Type 2-include-Hypotrichosis', 'Diabetes Mellitus, Type 2-associated-Hypotrichosis', 'Hypotrichosis-associated-Diabetes Mellitus, Type 2', 'Torsades de Pointes-associated-Atrophy', 'Atrophy-associated-Torsades de Pointes', 'Kidney Diseases-involve-Glomerulonephritis', 'Ossification of Posterior Longitudinal Ligament-used-Death', 'Mitochondrial Diseases-mediate-Inflammation', 'Death-used-Osteoarthritis', 'Asthma-exposed-Pulmonary Disease, Chronic Obstructive', 'Asthma-exist-Gastrointestinal Diseases', 'Asthma-exist-Cardiovascular Diseases', 'Asthma-exist-Heredodegenerative Disorders, Nervous System', 'Asthma-exist-Diabetes Mellitus', 'Asthma-exist-Kidney Diseases', 'Inflammation-include-Stroke', 'Dyslipidemias-increase-Bone Resorption', 'Leukemia, Myeloid, Acute-involved-Inflammation', 'Myotonic Dystrophy-characterized-Hyperglycemia', 'Hyperglycemia-characterized-Insulin Resistance', 'Weight Loss-induce-Death', 'Osteoporosis-indicate-Fractures, Bone', 'Ischemia-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-Ischemia', 'Neurodegenerative Diseases-seen-Alzheimer Disease', 'Neurodegenerative Diseases-seen-Parkinson Disease', 'Neurodegenerative Diseases-export-Parkinson Disease', 'Dementia-find-Anhedonia', 'Glioma-exhibit-Astrocytoma', 'HIV Infections-prevent-Neurodegenerative Diseases', 'Parkinson Disease-accompanied-Death', 'Death-linked-Parkinson Disease', 'Leukemia-delay-Neoplasms', 'Cardiovascular Diseases-associated-Hypotension', 'Hypotension-associated-Cardiovascular Diseases', 'Cardiac Output, Low-fall-Seizures', 'Anemia-tend-Ischemia', 'Anemia-cause-Ischemia', 'Anemia-cause-Hypoxia', 'Anemia-increase-Infections', 'Wounds and Injuries-induce-Cardiovascular Diseases', 'Anemia-cause-Death', 'Fractures, Bone-tend-Ischemia', 'Fractures, Bone-cause-Ischemia', 'Fractures, Bone-cause-Hypoxia', 'Wounds and Injuries-cause-Anemia', 'Fractures, Bone-increase-Infections', 'Cardiovascular Diseases-cause-Anemia', 'Ischemia-increase-Infections', 'Hypoxia-increase-Infections', 'Seizures-precede-Ischemia', 'Seizures-precede-Hemorrhage', 'Seizures-precede-Stroke', 'Seizures-distinguish-Stroke', 'Death-decrease-Multiple Trauma', 'Coagulation Protein Disorders-characterized-Hearing Loss, Sudden', 'Inflammation-caused-Hemorrhage', 'Lung Injury-result-Lung Diseases', 'Aneurysm-linked-Stroke', 'Syncope-present-Hypotension, Orthostatic', 'Enterovirus Infections-explore-Infections', 'Hypertension-used-Sarcopenia', 'Inflammation-implicated-Dementia', 'Cardiovascular Diseases-defined-Cerebrovascular Disorders', 'Prostatic Neoplasms-dubbed-Neoplasms', 'Pneumococcal Infections-result-Death', 'Seizures-result-Cerebral Infarction', 'Epilepsy, Tonic-Clonic-result-Cerebral Infarction', 'Hemorrhage-lead-Shock, Hemorrhagic', 'Hemorrhage-lead-Acute Kidney Injury', 'Hemorrhage-lead-Renal Insufficiency, Chronic', 'Dementia-enrolled-Parkinson Disease', 'HIV Infections-outline-Inflammation', 'Sarcopenia-diagnose-Obesity', 'Neoplasms-required-Neoplasm Metastasis', 'Carcinoma, Basal Cell-include-Neoplasms', 'Immunologic Deficiency Syndromes-reported-Respiratory Insufficiency', 'Chronobiology Disorders-associate-Leukoencephalopathies', 'Leukoencephalopathies-associate-Chronobiology Disorders', 'Obesity-occur-Atherosclerosis', 'Hypertension-include-Communicable Diseases', 'Hepatolenticular Degeneration-cause-Heart Failure', 'Atrial Fibrillation-affect-Stroke', 'Atrial Fibrillation-affect-Heart Failure', 'Renal Insufficiency-increase-Bradycardia', 'Death-caused-Diabetes Mellitus', 'Diabetes Mellitus-coupled-Heart Diseases', 'Obesity-regulated-Muscle Weakness', 'Communicable Diseases-explained-Obesity', 'Communicable Diseases-progress-Sarcopenia', 'Obesity-progress-Sarcopenia', 'Death-remain-Kidney Diseases', 'Death-contribute-Cardiovascular Diseases', 'Kidney Diseases-contribute-Cardiovascular Diseases', 'Dementia-considered-Death', 'Death-increased-Prediabetic State', 'Death-increased-Diabetes Mellitus', 'Huntington Disease-protect-Death', 'Dementia-retain-Ovarian Neoplasms', 'Ketosis-demonstrate-Alzheimer Disease', 'Ketosis-modify-Alzheimer Disease', 'Dementia-focused-Nervous System Diseases', 'Carcinoma, Hepatocellular-cause-Death', 'Infections-treat-Neoplasms', 'Cardio-Renal Syndrome-reflect-Renal Insufficiency', 'Arrhythmias, Cardiac-impact-Stroke', 'Arrhythmias, Cardiac-impact-Thromboembolism', 'Arrhythmias, Cardiac-impact-Dementia', 'Arrhythmias, Cardiac-impact-Heart Failure', 'Atrophy-include-Dementia', 'Hypertension-related-Obesity', 'Hypertension-known-Obesity', 'Obesity-known-Cardiovascular Diseases', 'Obesity-suffer-Musculoskeletal Pain', 'Death-observed-Chest Pain', 'Death-observed-Dyspnea', 'Death-observed-Hypertension', 'Death-observed-Diabetes Mellitus', 'Death-observed-Renal Insufficiency, Chronic', 'Death-observed-Ventricular Remodeling', 'Death-observed-Myocardial Infarction', 'Cerebral Small Vessel Diseases-cause-Stroke, Lacunar', 'Cluster Headache-associated-Hypertension', 'Hypertension-associated-Cluster Headache', 'Muscular Dystrophy, Duchenne-associated-Kidney Diseases', 'Kidney Diseases-associated-Muscular Dystrophy, Duchenne', 'Renal Insufficiency, Chronic-consider-Muscular Dystrophy, Duchenne', 'Pulmonary Disease, Chronic Obstructive-linked-Diabetes Mellitus', 'Osteoporosis-encourage-Hip Fractures', 'Cerebral Small Vessel Diseases-associated-Stroke, Lacunar', 'Stroke, Lacunar-associated-Cerebral Small Vessel Diseases', 'Adenomatous Polyposis Coli-use-Neoplasms', 'Neurodegenerative Diseases-result-Dementia', 'Atrial Fibrillation-present-Fractures, Bone', 'Neurodegenerative Diseases-associated-Memory Disorders', 'Memory Disorders-associated-Neurodegenerative Diseases', 'Death-balance-Dementia', 'Stroke-admitted-Radiculopathy', 'Stroke-admitted-Myelitis', 'Multiple Myeloma-admitted-Radiculopathy', 'Multiple Myeloma-admitted-Myelitis', 'Amyloidosis-accompany-Tauopathies', 'Hodgkin Disease-represent-Neoplasms', 'Hodgkin Disease-represent-Lymphoma, Follicular', 'Muscle Weakness-associated-Pain', 'Pain-associated-Muscle Weakness', 'Fractures, Bone-exhibit-Muscular Dystrophy, Duchenne', 'Muscular Dystrophy, Duchenne-tend-Fractures, Bone', 'Muscular Dystrophy, Duchenne-underestimate-Fractures, Bone', 'HIV Infections-predict-Death', 'Thromboembolism-assumed-Heart Failure', 'Thromboembolism-assumed-Atrial Fibrillation', 'Immunologic Deficiency Syndromes-assess-Death', 'Hypotension-suppress-Neoplasms', 'Hypotension-maintain-Neoplasms', 'Atrial Fibrillation-prevent-Dementia', 'Stroke-prevent-Dementia', 'Dementia-censore-Stroke', 'Stroke-yield-Dementia', 'Sleep Initiation and Maintenance Disorders-combine-Dementia', 'Chronic Pain-assessed-Pain', 'Osteoporosis-reduce-Inflammation', 'Osteoporosis-reverse-Bone Neoplasms', 'Inflammation-reverse-Bone Neoplasms', 'Brain Ischemia-reduce-Brain Edema', 'Brain Ischemia-reduce-Neurotoxicity Syndromes', 'Coronary Artery Disease-predict-Vision Disorders', 'Urinary Incontinence-predict-Vision Disorders', 'Cardiomyopathy, Hypertrophic-characterized-Hypertrophy, Left Ventricular', 'Cardiomyopathy, Hypertrophic-characterized-Airway Obstruction', 'Genetic Diseases, Inborn-characterized-Hypertrophy, Left Ventricular', 'Genetic Diseases, Inborn-characterized-Airway Obstruction', 'Nervous System Diseases-alleviate-Neurodegenerative Diseases', 'Cardiovascular Diseases-include-Hypertension', 'Cardiovascular Diseases-affect-Hypertension', 'Cardiovascular Diseases-include-Peripheral Arterial Disease', 'Cardiovascular Diseases-affect-Peripheral Arterial Disease', 'Cardiovascular Diseases-include-Coronary Artery Disease', 'Cardiovascular Diseases-affect-Coronary Artery Disease', 'Alzheimer Disease-include-Heredodegenerative Disorders, Nervous System', 'Aneuploidy-contribute-Infertility, Female', 'Hearing Loss, Central-involve-Deafness', 'Neoplasms-experience-Hearing Loss', 'Neoplasms-experience-Tinnitus', 'Cerebral Infarction-become-Cerebrovascular Disorders', 'Death-study-Cardiovascular Diseases', 'Cerebrovascular Disorders-become-Death', 'Disease-become-Atherosclerosis', 'Inflammatory Bowel Diseases-refer-Inflammation', 'Inflammatory Bowel Diseases-result-Neoplasms', 'Inflammatory Bowel Diseases-result-Neoplasm Invasiveness', 'Neoplasms-needed-Leukemia', 'Neoplasms-needed-Breech Presentation', 'Cerebral Small Vessel Diseases-contribute-Alzheimer Disease', 'Sarcopenia-contribute-Neoplasms', 'Hypoxia-promote-Cardiovascular Diseases', 'Pain-caused-Fatigue', 'Communicable Diseases-contribute-Fever', 'Cardiotoxicity-increase-Death', 'Cardiotoxicity-increase-Neoplasms', 'Neoplasms-represent-Long QT Syndrome', 'Nervous System Autoimmune Disease, Experimental-underlie-Death', 'Alzheimer Disease-identified-Dementia', 'Hemangiosarcoma-arised-Pleurisy', 'Neoplasms-demonstrate-Memory Disorders', 'Hypertension-raised-Arthritis, Rheumatoid', 'Death-raised-Arthritis, Rheumatoid', 'Kidney Failure, Chronic-aged-Arthritis, Rheumatoid', 'Arthritis, Rheumatoid-get-Kidney Failure, Chronic', 'Postpartum Hemorrhage-associated-Death', 'Death-associated-Postpartum Hemorrhage', 'Hypertriglyceridemia-associated-Cardiac Output, Low', 'Cardiac Output, Low-associated-Hypertriglyceridemia', 'Hypertriglyceridemia-fall-Cardiac Output, Low', 'HIV Infections-resemble-Chronic Disease', 'HIV Infections-induce-Dysbiosis', 'HIV Infections-organized-Acquired Immunodeficiency Syndrome', 'HIV Infections-exacerbated-Coinfection', 'Obesity-driven-Communicable Diseases', 'Hemolytic-Uremic Syndrome-reversed-Renal Insufficiency', 'Endometrial Neoplasms-come-Infertility, Female', 'Hypertension-exert-Arthritis', 'Diabetes Mellitus-treat-Alzheimer Disease', 'Airway Obstruction-associated-Pulmonary Disease, Chronic Obstructive', 'Pulmonary Disease, Chronic Obstructive-associated-Airway Obstruction', 'Airway Obstruction-associated-Malnutrition', 'Malnutrition-associated-Airway Obstruction', 'Pulmonary Disease, Chronic Obstructive-associated-Malnutrition', 'Malnutrition-associated-Pulmonary Disease, Chronic Obstructive', 'Dementia-shown-Death', 'Dementia-shown-Obesity', 'Death-shown-Obesity', 'Muscle Weakness-use-Sarcopenia', 'Muscle Weakness-examine-Death', 'Death-observed-Muscle Weakness', 'Breast Neoplasms-display-Death', 'Breast Neoplasms-result-Neoplasms', 'Obesity-associated-Mitochondrial Diseases', 'Mitochondrial Diseases-associated-Obesity', 'Cardiovascular Diseases-associated-Gout', 'Gout-associated-Cardiovascular Diseases', 'Heart Failure-associated-Metabolic Diseases', 'Metabolic Diseases-associated-Heart Failure', 'Heart Failure-associated-Mitochondrial Diseases', 'Mitochondrial Diseases-associated-Heart Failure', 'Mitochondrial Diseases-include-Metabolic Diseases', 'Heart Diseases-include-Metabolic Diseases', 'Heart Failure-cause-Death', 'Dyskeratosis Congenita-characterized-Abnormalities, Drug-Induced', 'Bone Marrow Failure Disorders-consist-Microcephaly', 'Bone Marrow Failure Disorders-consist-Growth Disorders', 'Lymphopenia-consist-Microcephaly', 'Lymphopenia-consist-Growth Disorders', 'Abnormalities, Drug-Induced-consist-Microcephaly', 'Abnormalities, Drug-Induced-consist-Growth Disorders', 'Neurodegenerative Diseases-serve-Death', 'Dementia, Vascular-compared-Dementia', 'Alzheimer Disease-compared-Dementia', 'HIV Infections-used-Fatigue', 'HIV Infections-stratified-Fatigue', 'Fatigue-assess-HIV Infections', 'Fractures, Bone-develop-Wounds and Injuries', 'Progeria-experience-Atherosclerosis', 'Progeria-experience-Death', 'Progeria-experience-Stroke', 'Atherosclerosis-experience-Death', 'Atherosclerosis-experience-Stroke', 'Parkinson Disease-predisposed-Neurodegenerative Diseases', 'Parkinson Disease-predisposed-Parkinson Disease, Secondary', 'Parkinson Disease-predisposed-Pain', 'Neurodegenerative Diseases-predisposed-Pain', 'Neurodegenerative Diseases-take-Pain', 'Parkinson Disease, Secondary-predisposed-Pain', 'Pain-underpinn-Neurodegenerative Diseases', 'Drug-Related Side Effects and Adverse Reactions-play-Mitochondrial Diseases', 'Osteoarthritis-linked-Bone Diseases', 'Bone Diseases-associated-Obesity', 'Obesity-associated-Bone Diseases', 'Obesity-regard-Metabolic Diseases', 'Ovarian Diseases-associated-Metabolic Diseases', 'Metabolic Diseases-associated-Ovarian Diseases', 'Muscular Diseases-affect-Glucose Metabolism Disorders', 'Carpal Tunnel Syndrome-seen-Spinal Stenosis', 'Amyloidosis-included-Polyneuropathies', 'Cardiac Output, Low-fall-Parkinson Disease', 'Wounds and Injuries-complicate-Delirium', 'Drug Overdose-complicate-Delirium', 'Fractures, Bone-compare-Weight Loss', 'Fractures, Bone-compare-Obesity', 'Aneurysm-coupled-Fibrosis', 'Aneurysm-coupled-Inflammation', 'Aneurysm-drive-Anophthalmos', 'Fibrosis-drive-Anophthalmos', 'Inflammation-drive-Anophthalmos', 'Pneumonia-considered-Respiratory Distress Syndrome', 'Infections-lead-Respiratory Distress Syndrome', 'Infections-describe-Respiratory Distress Syndrome', 'Pneumonia-induced-Infections', 'Respiratory Distress Syndrome-occur-Pneumonia', 'Neoplasms-affect-Aneuploidy', 'Pneumonia-included-Infections', 'Respiratory Distress Syndrome-included-Infections', 'Zoonoses-associated-Infections', 'Infections-associated-Zoonoses', 'Immunologic Deficiency Syndromes-give-Opportunistic Infections', 'Immunologic Deficiency Syndromes-give-Chronic Disease', 'Immunologic Deficiency Syndromes-give-Death', 'Immunologic Deficiency Syndromes-give-HIV Infections', 'Opportunistic Infections-give-Chronic Disease', 'Opportunistic Infections-give-Death', 'Opportunistic Infections-give-HIV Infections', 'Chronic Disease-give-Death', 'Chronic Disease-give-HIV Infections', 'Immunologic Deficiency Syndromes-occur-Death', 'Delirium-triggered-Acute Disease', 'Proteinuria-show-Death', 'Infections-minimise-Death', 'Factor XII Deficiency-remain-Proteinuria', 'Sexual Dysfunction, Physiological-involve-Pain', 'Pain-involve-Sleep Wake Disorders', 'Fatigue-involve-Pain', 'Sleep Wake Disorders-diagnosed-Alzheimer Disease', 'Brain Diseases-characterized-Retinal Degeneration', 'Sarcopenia-considered-Osteoarthritis', 'Brain Neoplasms-operate-Appendicitis', 'Aneurysm-include-Hypertension', 'Arrhythmias, Cardiac-include-Hypertension', 'Heart Failure-include-Hypertension', 'Heart Failure-hospitalized-Atrioventricular Block', 'Fibrosis-refer-Multiple Organ Failure', 'Communicable Diseases-include-Fibrosis', 'Communicable Diseases-include-Hypertrophy', 'Communicable Diseases-conducted-Hypertrophy', 'Cerebrovascular Disorders-related-Alzheimer Disease', 'Erectile Dysfunction-precede-Aneurysm', 'Osteoporosis-recover-Fractures, Bone', 'Alzheimer Disease-recover-Fractures, Bone', 'Fractures, Bone-take-Death', 'Pneumococcal Infections-live-HIV Infections', 'Pneumococcal Infections-administer-HIV Infections', 'Carcinoma, Hepatocellular-reduce-Alzheimer Disease', 'Hyperpigmentation-show-Skin Diseases', 'Osteoarthritis-associated-Myotonic Dystrophy', 'Myotonic Dystrophy-associated-Osteoarthritis', 'Werner Syndrome-include-Calcinosis', 'Werner Syndrome-include-Pain', 'Werner Syndrome-include-Skin Ulcer', 'Williams Syndrome-include-Calcinosis', 'Williams Syndrome-include-Pain', 'Williams Syndrome-include-Skin Ulcer', 'Calcinosis-include-Aging, Premature', 'Aging, Premature-include-Pain', 'Skin Ulcer-include-Aging, Premature', 'Immunologic Deficiency Syndromes-occur-Alzheimer Disease', 'Immunologic Deficiency Syndromes-serve-Alzheimer Disease', 'Disease-result-Ventricular Fibrillation', 'Hypertension, Pulmonary-result-Disease', 'Disease-result-Atrial Fibrillation', 'Death-Predictor-Wounds and Injuries', 'Death-Predictor-Wounds, Nonpenetrating', 'Wounds and Injuries-predict-Respiratory Distress Syndrome', 'Wounds and Injuries-predict-Heart Arrest', 'Glycogen Storage Disease Type II-investigate-Myeloproliferative Disorders', 'Death-influence-Hemorrhage', 'Stroke-influence-Hemorrhage', 'Death-compare-Dementia', 'Dementia-caused-Brain Diseases', 'Infarction-caused-Cerebral Infarction', 'Alzheimer Disease-increase-Neurotoxicity Syndromes', 'Alzheimer Disease-worsen-Inflammation', 'Neurotoxicity Syndromes-increase-Inflammation', 'Cardiovascular Diseases-appear-Parkinson Disease', 'Cardiovascular Diseases-aggravate-Hypotension, Orthostatic', 'Parkinson Disease-aggravate-Hypotension, Orthostatic', 'Hypotension, Orthostatic-appear-Parkinson Disease', 'Dyslipidemias-exhibit-Parkinson Disease', 'Stroke-identified-Parkinson Disease', 'Stroke-demonstrate-Dyslipidemias', 'Hypertension-identified-Parkinson Disease', 'Hypertension-demonstrate-Dyslipidemias', 'Parkinson Disease-demonstrate-Dyslipidemias', 'Adrenocortical Carcinoma-follow-Carcinogenesis', 'Adrenocortical Carcinoma-follow-Neoplasms', 'Obesity-complete-Weight Loss', 'Adenoma-include-Adrenocortical Carcinoma', 'Adrenocortical Carcinoma-present-Neoplasms', 'Lung Diseases-derive-Pulmonary Disease, Chronic Obstructive', 'Lung Diseases-derive-Pulmonary Fibrosis', 'Lung Diseases-derive-Hypertension, Pulmonary', 'Sclerosis-characterized-Vascular System Injuries', 'Atrial Fibrillation-leave-Cerebral Infarction', 'Cardiovascular Diseases-experience-Constipation', 'Calcinosis-analysed-Anastomotic Leak', 'Hypertension-correlated-Anastomotic Leak', 'Neoplasms-correlated-Anastomotic Leak', 'Parkinson Disease-develop-Dyskinesia, Drug-Induced', 'Neuroleptic Malignant Syndrome-differ-Sleep Wake Disorders', 'Hematoma, Subdural-constitute-Parkinson Disease, Secondary', 'Hematoma, Subdural-follow-Craniocerebral Trauma', 'Hematoma, Subdural-occur-Craniocerebral Trauma', 'Hematoma, Subdural-follow-Wounds and Injuries', 'Hematoma, Subdural-occur-Wounds and Injuries', 'Communicable Diseases-identify-Coronary Artery Disease', 'Coronary Artery Disease-become-Chronic Disease', 'Sarcopenia-regulate-Huntington Disease', 'Sarcopenia-regulate-Parkinson Disease', 'Sarcopenia-regulate-Fatty Liver', 'Infections-prevent-Autoimmune Diseases', 'Pulmonary Disease, Chronic Obstructive-increase-Death', 'Alzheimer Disease-cause-Neurodegenerative Diseases', 'Neurodegenerative Diseases-result-Memory Disorders', 'Cardiovascular Diseases-include-Alzheimer Disease', 'Neurodegenerative Diseases-accompanied-Inflammation', 'Diabetes Mellitus-decrease-Dementia', 'Chronobiology Disorders-associated-Neurodegenerative Diseases', 'Neurodegenerative Diseases-associated-Chronobiology Disorders', 'Chronobiology Disorders-associated-Alzheimer Disease', 'Alzheimer Disease-associated-Chronobiology Disorders', 'Sleep Wake Disorders-associated-Neurodegenerative Diseases', 'Neurodegenerative Diseases-associated-Sleep Wake Disorders', 'Breast Neoplasms-assigned-Weight Loss', 'Death-warrant-Pneumonia', 'Sarcopenia-report-Death', 'Obesity-composed-Hyperplasia', 'Learning Disabilities-receive-Dementia', 'Dyspnea-predict-Death', 'Dyspnea-include-Pulmonary Disease, Chronic Obstructive', 'Lupus Vasculitis, Central Nervous System-include-Lupus Erythematosus, Systemic', 'Lupus Vasculitis, Central Nervous System-observed-Lupus Erythematosus, Systemic', 'Lupus Vasculitis, Central Nervous System-present-Lupus Erythematosus, Systemic', 'Sarcopenia-result-Death', 'Cardiovascular Diseases-contribute-Sarcopenia', 'Sarcopenia-seem-Cardiovascular Diseases', 'Bone Diseases, Metabolic-seem-Cardiovascular Diseases', 'Glucose Intolerance-contribute-Sarcopenia', 'Sarcopenia-related-Cardiovascular Diseases', 'Vascular Calcification-suspect-Sarcopenia', 'Cardiovascular Diseases-seem-Sarcopenia', 'Death-seen-Hepatitis, Viral, Human', 'Death-seen-HIV Infections', 'Death-do-Poisoning', 'Osteoporosis-base-Muscular Dystrophy, Duchenne', 'Fractures, Bone-affected-Osteoarthritis', 'Acute Pain-become-Neuralgia', 'Acute Pain-known-Neuralgia', 'Periodontitis-considered-Dysbiosis', 'Periodontitis-explained-Dysbiosis', 'Neutropenia-develop-Periodontitis', 'Periodontitis-effectuate-Gingival Recession', 'Seizures-impacted-Infections', 'Seizures-impacted-Neoplasms', 'Alzheimer Disease-diagnosed-Stroke', 'Periodontitis-found-Alzheimer Disease', 'Ischemia-suggest-Cardiomyopathy, Dilated', 'Tooth Attrition-reduce-Wounds and Injuries', 'Neoplasms-show-Death', 'Neoplasms-reach-Death', 'Hemophilia A-improve-Hemorrhage', 'Hemophilia A-treat-Hemorrhage', 'Respiration Disorders-caused-Arbovirus Infections', 'Arbovirus Infections-classified-Chronic Disease', 'Chediak-Higashi Syndrome-predict-Death', 'Death-assessed-Chediak-Higashi Syndrome', 'Ossification of Posterior Longitudinal Ligament-report-Seizures', 'Genetic Diseases, Inborn-tops-Fanconi Anemia', 'Infections-induce-Inflammation', 'Parkinson Disease-characterized-Hypotension', 'Parkinson Disease-characterized-Infections', 'Hypotension-characterized-Infections', 'Neurodegenerative Diseases-underlie-Inflammation', 'Denys-Drash Syndrome-reflect-Albuminuria', 'Alzheimer Disease-marked-Neurodegenerative Diseases', 'Alzheimer Disease-marked-Atrophy', 'Cardiomyopathies-require-Hepatopulmonary Syndrome', 'Cardiomyopathies-require-Hypertension', 'Metabolic Syndrome-associated-Osteoarthritis', 'Osteoarthritis-associated-Metabolic Syndrome', 'Death-include-Necrosis', 'Turner Syndrome-concern-Osteoporosis', 'Osteoporosis-suffer-Fractures, Bone', 'Turner Syndrome-estimated-Fractures, Bone', 'Turner Syndrome-suffer-Fractures, Bone', 'Turner Syndrome-regard-Osteoporosis', 'Turner Syndrome-describe-Osteoporosis', 'Turner Syndrome-describe-Fractures, Compression', 'Anastomotic Leak-associated-Death', 'Death-associated-Anastomotic Leak', 'Sleep Wake Disorders-catastrophize-Pain', 'Cerebrovascular Disorders-remain-Cerebral Amyloid Angiopathy', 'Death-observed-Shock, Cardiogenic', 'Autoimmune Diseases-vary-Neoplasms', 'Autoimmune Diseases-linked-Neoplasms', 'Obesity-increase-Death', 'Kidney Diseases-predict-Death', 'Death-increase-Atherosclerosis', 'Thyroid Neoplasms-followed-Neoplasms', 'Diabetes Mellitus-linked-Back Pain', 'Diabetes Mellitus-linked-Intervertebral Disc Degeneration', 'Hepatitis B-complicated-Carcinoma, Hepatocellular', 'Hepatitis B-complicated-Liver Cirrhosis', 'Hepatitis B-complicated-Neoplasms', 'Parkinson Disease-characterized-Dementia', 'Dementia-lead-Death', 'Dyslipidemias-predispose-Cardiovascular Diseases', 'Syncope, Vasovagal-associated-Syncope', 'Syncope-associated-Syncope, Vasovagal', 'HIV Infections-related-Neoplasms', 'HIV Infections-make-Neoplasms', 'Eye Diseases-emphasize-Glaucoma', 'Eye Diseases-associated-Glaucoma', 'Glaucoma-associated-Eye Diseases', 'Lewy Body Disease-follow-Alzheimer Disease', 'Lewy Body Disease-associate-Alzheimer Disease', 'Alzheimer Disease-associate-Lewy Body Disease', 'Neoplasms-associated-Stroke', 'Stroke-associated-Neoplasms', 'Neoplasms-associated-Hemorrhage', 'Hemorrhage-associated-Neoplasms', 'Stroke-cause-Death', 'Calcinosis-comprise-Aortic Valve Stenosis', 'Calcinosis-comprise-Heart Failure', 'Calcinosis-comprise-Death', 'Hypertension-shared-Atherosclerosis', 'Calcinosis-result-Ventricular Outflow Obstruction', 'Cerebral Small Vessel Diseases-differentiate-Death', 'Diabetes Mellitus-include-Shy-Drager Syndrome', 'Neoplasms-include-Shy-Drager Syndrome', 'Mitochondrial Diseases-include-Shy-Drager Syndrome', 'Cerebral Small Vessel Diseases-identify-Death', 'Fractures, Bone-take-Diabetes Mellitus', 'Obesity-avoid-Metabolic Syndrome', 'Hypertension-avoid-Metabolic Syndrome', 'Cardiovascular Diseases-avoid-Metabolic Syndrome', 'Atrophy-develop-Alzheimer Disease', 'Chronic Disease-caused-Critical Illness', 'Neoplasms-caused-Critical Illness', 'Cardiovascular Diseases-caused-Critical Illness', 'Neurodegenerative Diseases-caused-Critical Illness', 'Autoimmune Diseases-caused-Critical Illness', 'Werner Syndrome-compared-Sarcopenia', 'Neoplasms-witness-Primary Myelofibrosis', 'Ulcer-transition-Crohn Disease', 'Colitis-transition-Crohn Disease', 'Stroke-calculated-Coronary Artery Disease', 'Stroke-calculated-Myocardial Infarction', 'Brain Injuries, Traumatic-associated-Stroke', 'Stroke-associated-Brain Injuries, Traumatic', 'Death-drive-Diabetes Mellitus', 'Acquired Immunodeficiency Syndrome-follow-Skin Neoplasms', 'Chronic Disease-prevent-Malnutrition', 'Fatigue-assessed-Neoplasms', 'Osteoporosis-include-Sarcopenia', 'Sarcopenia-evaluated-Osteoporosis', 'Wounds and Injuries-caused-Hyponatremia', 'Bone Diseases, Metabolic-show-Osteoporosis', 'Hyponatremia-reduce-Wounds and Injuries', 'Fractures, Bone-reduce-Wounds and Injuries', 'Hearing Loss-used-Pain', 'Headache-reduced-Back Pain', 'Heart Diseases-discuss-Heart Defects, Congenital', 'Heart Defects, Congenital-associated-Myotonic Dystrophy', 'Myotonic Dystrophy-associated-Heart Defects, Congenital', 'Dementia-lead-Dyskinesia, Drug-Induced', 'Dementia-lead-Parkinson Disease, Secondary', 'Tauopathies-lead-Neurologic Manifestations', 'Tauopathies-lead-Death', 'Sleep Apnea Syndromes-lead-Hypoxia', 'Cardiomegaly-include-Cardiovascular Diseases', 'Chronic Disease-lead-Hypoxia', 'Fibrosis-include-Cardiovascular Diseases', 'Hypotension-include-Cardiovascular Diseases', 'Neurodegenerative Diseases-include-Metabolic Diseases', 'Alzheimer Disease-include-Metabolic Diseases', 'Diabetes Mellitus, Type 2-trigger-Inflammation', 'Pain Insensitivity, Congenital-reduce-Delirium', 'Pain Insensitivity, Congenital-control-Pain', 'Hypotension-observed-Diabetes Mellitus, Type 2', 'Disorders of Excessive Somnolence-taken-Epilepsy', 'Alzheimer Disease-play-Nerve Degeneration', 'Pneumococcal Infections-related-Death', 'Pneumococcal Infections-include-Pneumonia', 'Dyspepsia-defined-Pain', 'Blood Platelet Disorders-composed-Neoplasms', 'Migraine Disorders-observed-Graft vs Host Disease', 'Obesity-diagnosed-Sarcopenia', 'Obesity-assessed-Sarcopenia', 'Obesity-diagnose-Sarcopenia', 'Hematoma, Subdural, Chronic-necessitate-Cerebral Hemorrhage', 'Hematoma-show-Hemorrhage', 'Hematoma-show-Hematoma, Subdural, Chronic', 'Cerebral Hemorrhage-show-Hemorrhage', 'Cerebral Hemorrhage-show-Hematoma, Subdural, Chronic', 'Infarction, Middle Cerebral Artery-prevent-Hematoma', 'Paresis-include-Nervous System Diseases', 'Cerebrovascular Disorders-increase-Death', 'Alzheimer Disease-characterized-Common Cold', 'Neurodegenerative Diseases-characterized-Common Cold', 'Gastritis-investigate-Infections', 'Status Epilepticus-related-Death', 'Death-diagnosed-Status Epilepticus', 'Death-evidence-Alzheimer Disease', 'Coma-level-Wounds and Injuries', 'Renal Insufficiency-associated-Hypoglycemia', 'Hypoglycemia-associated-Renal Insufficiency', 'Obesity-associated-Hypoglycemia', 'Hypoglycemia-associated-Obesity', 'Heart Diseases-associated-Hypoglycemia', 'Hypoglycemia-associated-Heart Diseases', 'Seizures-associated-Sclerosis', 'Sclerosis-associated-Seizures', 'Cerebral Infarction-identified-Malocclusion', 'Bone Diseases, Metabolic-defined-Osteoporosis', 'Smoke Inhalation Injury-associated-Death', 'Death-associated-Smoke Inhalation Injury', 'Delirium-adjusted-Stroke', 'Atrophy-associated-Delirium', 'Delirium-associated-Atrophy', 'Atrial Fibrillation-decline-Ischemia', 'Hypertension-decline-Ischemia', 'Obesity-decline-Ischemia', 'Chronic Pain-consider-Sexual Dysfunction, Physiological', 'Chronic Pain-consider-Sarcopenia', 'Metabolic Diseases-associated-Atherosclerosis', 'Atherosclerosis-associated-Metabolic Diseases', 'Autoimmune Diseases-suffer-Atrophy', 'Neoplasms-compare-Colorectal Neoplasms', 'Malaria-distributed-Infections', 'Infections-contribute-Malaria', 'Tuberculosis-whichpredispose-Communicable Diseases', 'Alzheimer Disease-use-Chronic Disease', 'Neoplasms-reported-Thyroid Neoplasms', 'Anemia-include-Diabetes Mellitus', 'Metabolic Syndrome-include-Dementia', 'Aneurysm-include-Dementia', 'Inflammation-include-Dementia', 'Anemia-include-Dementia', 'Diabetes Mellitus-rising-Hypertension', 'Respiratory Insufficiency-limit-Death', 'Carcinoma, Hepatocellular-constitute-Hepatitis C', 'Musculoskeletal Diseases-improve-Sarcopenia', 'Tuberculosis, Multidrug-Resistant-associated-Death', 'Death-associated-Tuberculosis, Multidrug-Resistant', 'Neurodegenerative Diseases-associated-Neurotoxicity Syndromes', 'Neurotoxicity Syndromes-associated-Neurodegenerative Diseases', 'Neurodegenerative Diseases-linked-Proteostasis Deficiencies', 'Neurotoxicity Syndromes-linked-Proteostasis Deficiencies', 'HIV Infections-experience-Frailty', 'Alzheimer Disease-occur-Hematologic Diseases', 'Sleep Wake Disorders-thought-Hypothalamic Neoplasms', 'Sleep Wake Disorders-indicate-Hypothalamic Neoplasms', 'Hypothalamic Neoplasms-act-Sleep Wake Disorders', 'Neurodegenerative Diseases-exhibit-Sleep Wake Disorders', 'Lung Diseases-related-Cystic Fibrosis', 'Cystic Fibrosis-result-Chronic Disease', 'Lung Diseases-result-Cystic Fibrosis', 'Lung Diseases-result-Chronic Disease', 'Renal Insufficiency, Chronic-utilized-Kidney Diseases', 'Diabetes Mellitus-combined-Renal Insufficiency, Chronic', 'Prediabetic State-associated-Renal Insufficiency, Chronic', 'Renal Insufficiency, Chronic-associated-Prediabetic State', 'Diabetes Mellitus, Type 2-associate-Death', 'Death-associate-Diabetes Mellitus, Type 2', 'Drug-Related Side Effects and Adverse Reactions-result-Death', 'Stroke-accompanied-Brain Injuries', 'Brain Injuries-associated-Stroke', 'Stroke-associated-Brain Injuries', 'Constipation-defined-Sarcopenia', 'Sarcopenia-warranted-Constipation', 'Fatigue Syndrome, Chronic-related-Muscular Atrophy', 'Fatigue Syndrome, Chronic-underpinn-Muscular Atrophy', 'Fatigue Syndrome, Chronic-related-Heart Failure', 'Fatigue Syndrome, Chronic-related-Pulmonary Disease, Chronic Obstructive', 'Fatigue Syndrome, Chronic-related-Kidney Failure, Chronic', 'Fatigue Syndrome, Chronic-related-Muscular Dystrophies', 'Fatigue Syndrome, Chronic-related-Muscular Diseases', 'Fatigue Syndrome, Chronic-related-Multiple Sclerosis', 'Muscular Atrophy-mediated-Heart Failure', 'Muscular Atrophy-mediated-Pulmonary Disease, Chronic Obstructive', 'Muscular Atrophy-mediated-Kidney Failure, Chronic', 'Chronic Disease-base-Death', 'Severe Acute Respiratory Syndrome-base-Death', 'Carcinoma, Merkel Cell-understand-Neoplasms', 'Carcinoma, Merkel Cell-known-Skin Neoplasms', 'Inflammation-elicited-Sepsis', 'Inflammation-induce-Cerebral Infarction', 'Inflammation-known-Brain Diseases', 'Sepsis-known-Cerebral Infarction', 'Sepsis-induce-Cerebral Infarction', 'Sepsis-associated-Brain Diseases', 'Brain Diseases-associated-Sepsis', 'Sepsis-known-Brain Diseases', 'Cerebral Infarction-known-Brain Diseases', 'Sleep Initiation and Maintenance Disorders-move-Death', 'Death-live-Pain', 'Dyskinesia, Drug-Induced-attenuate-Parkinson Disease', 'Parkinson Disease-treat-Dyskinesia, Drug-Induced', 'Olfaction Disorders-show-Death', 'Pulmonary Arterial Hypertension-differentiate-Hypertension, Pulmonary', 'Pulmonary Arterial Hypertension-differentiate-Heart Failure, Diastolic', 'Neurotoxicity Syndromes-lead-Dementia', 'Calcinosis-linked-Vascular Calcification', 'Calcinosis-linked-Immunologic Deficiency Syndromes', 'Diabetes Mellitus-include-Calcinosis', 'Renal Insufficiency, Chronic-include-Calcinosis', 'Inflammation-play-Venous Thrombosis', 'Inflammation-play-Pulmonary Embolism', 'Inflammation-play-Death', 'Inflammation-play-Hip Fractures', 'Cerebrovascular Disorders-associated-Pulmonary Disease, Chronic Obstructive', 'Pulmonary Disease, Chronic Obstructive-associated-Cerebrovascular Disorders', 'Chemical and Drug Induced Liver Injury-include-Liver Diseases', 'Fatty Liver-associated-Metabolic Diseases', 'Metabolic Diseases-associated-Fatty Liver', 'Drug Resistant Epilepsy-occur-Epilepsy', 'Ischemia-followed-Cerebrovascular Disorders', 'Ischemia-result-Cerebrovascular Disorders', 'Mitochondrial Diseases-understand-Infections', 'Stroke-assess-Brain Ischemia', 'Sarcopenia-defined-Fractures, Bone', 'Sarcopenia-defined-Death', 'Sarcopenia-postulated-Malnutrition', 'Sarcopenia-postulated-Inflammation', 'Sarcopenia-impact-Death', 'Malnutrition-contribute-Myalgia', 'Inflammation-contribute-Myalgia', 'Cerebral Infarction-remain-Death', 'Cerebral Infarction-remain-Inflammation', 'Pulmonary Disease, Chronic Obstructive-caused-Death', 'Seizures-diagnosed-Stroke', 'Diabetes Mellitus-cure-Death', 'Inflammation-result-Atherosclerosis', 'Renal Insufficiency, Chronic-cause-Kidney Diseases', 'Renal Insufficiency, Chronic-cause-Cardiovascular Diseases', 'Death-observe-Liver Diseases', 'Death-observe-Sepsis', 'Death-observe-Chronic Disease', 'Lupus Erythematosus, Systemic-characterized-Inflammation', 'Autoimmune Diseases-characterized-Lupus Erythematosus, Systemic', 'Autoimmune Diseases-characterized-Inflammation', 'Autoimmune Diseases-characterized-Cardiovascular Diseases', 'Lupus Erythematosus, Systemic-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-Lupus Erythematosus, Systemic', 'Inflammation-characterized-Cardiovascular Diseases', 'Delirium-diagnosed-Malnutrition', 'Delirium-underlie-Malnutrition', 'Congenital Hyperinsulinism-observed-Consciousness Disorders', 'Delirium-involved-Sarcopenia', 'Neurogenic Inflammation-develop-Delirium', 'Neuroendocrine Tumors-develop-Delirium', 'Microvascular Rarefaction-develop-Delirium', 'HIV Infections-experience-Neurodegenerative Diseases', 'Cholecystitis, Acute-report-Fractures, Open', 'Cholecystitis, Acute-report-Fallopian Tube Diseases', 'Cerebral Infarction-occur-Brain Ischemia', 'Heart Arrest-occur-Brain Ischemia', 'Alzheimer Disease-acknowledged-Neurodegenerative Diseases', 'Muscular Dystrophy, Duchenne-elicit-Drug-Related Side Effects and Adverse Reactions', 'Periodontitis-diagnosed-Tooth Loss', 'Fractures, Bone-base-Renal Insufficiency, Chronic', 'Neoplasms-differ-Lung Neoplasms', 'Neoplasms-differ-Breast Neoplasms', 'Fibrosis-associated-Acute Lung Injury', 'Acute Lung Injury-associated-Fibrosis', 'Fibrosis-associated-Infections', 'Infections-associated-Fibrosis', 'Parasitic Diseases-enable-Malaria', 'Osteoarthritis-protect-Hypoxia', 'Hypoxia-restore-Osteoarthritis', 'Vision Disorders-suffer-Sarcopenia', 'Vision Disorders-exhibit-Sarcopenia', 'Vision Disorders-linked-Sarcopenia', 'Weight Loss-need-Hypertension', 'Diabetes Mellitus, Type 2-improve-Diabetes Mellitus', 'Peripheral Arterial Disease-associated-Atrial Fibrillation', 'Atrial Fibrillation-associated-Peripheral Arterial Disease', 'Genetic Diseases, Inborn-result-Nervous System Diseases', 'Neurotoxicity Syndromes-use-Kidney Diseases', 'Hydrocephalus-implanted-Brain Neoplasms', 'Metabolic Syndrome-associated-Bone Diseases, Metabolic', 'Bone Diseases, Metabolic-associated-Metabolic Syndrome', 'Cardiovascular Diseases-defined-Death, Sudden, Cardiac', 'Coronary Artery Disease-correlate-Death', 'Hip Fractures-estimated-Fractures, Bone', 'Hip Fractures-vary-Fractures, Bone', 'Anemia-recognized-Adrenal Insufficiency', 'Diabetes Mellitus-recognized-Adrenal Insufficiency', 'Adrenal Insufficiency-seem-Death', 'Anemia-show-Death', 'Anemia-show-Diabetes Mellitus', 'Diabetes Mellitus-hospitalized-Death', 'Infections-occur-Death', 'Leukoencephalopathies-link-Seizures', 'Sepsis-associated-Coinfection', 'Coinfection-associated-Sepsis', 'Sepsis-implicated-Coinfection', 'Muscle Weakness-involve-Sarcopenia', 'Vision Disorders-followed-Refractive Errors', 'Vision Disorders-cause-Cataract', 'Neuroaxonal Dystrophies-highlight-Cardiovascular Diseases', 'Neuroaxonal Dystrophies-highlight-Leukoencephalopathies', 'Amyloidosis-highlight-Cardiovascular Diseases', 'Amyloidosis-highlight-Leukoencephalopathies', 'Inflammation-participate-Aneurysm', 'Sarcopenia-evaluated-Hypertension', 'Neoplasms-cause-Hyperkinesis', 'Neoplasms-cause-Neurodegenerative Diseases', 'Hyperkinesis-drive-Neurodegenerative Diseases', 'Metabolic Diseases-include-Neoplasms', 'Reperfusion Injury-increase-Fibrosis', 'Dementia-develop-Sarcopenia', 'Pain-influence-Death', 'Mastocytosis, Systemic-contribute-Arbovirus Infections', 'Proteostasis Deficiencies-interfere-Arbovirus Infections', 'Chronic Disease-delay-Parkinson Disease', 'Cartilage Diseases-occur-Osteoarthritis', 'Bradycardia-coexist-Hypertension', 'Bradycardia-coexist-Coronary Artery Disease', 'Tachycardia-coexist-Hypertension', 'Tachycardia-coexist-Coronary Artery Disease', 'Cardiovascular Diseases-demonstrated-Atrial Fibrillation', 'Hemorrhage-occur-Thrombosis', 'Brain Injuries, Traumatic-increase-Neurodegenerative Diseases', 'Atrophy-observed-Brain Injuries, Traumatic', 'Brain Injuries, Traumatic-coincide-Neurodegenerative Diseases', 'Atrophy-differentiate-Brain Injuries, Traumatic', 'Respiratory Distress Syndrome-proceed-Hallucinations', 'Pneumonia-proceed-Hallucinations', 'Disease-show-Alzheimer Disease', 'Heart Failure-associated-Coronary Artery Disease', 'Coronary Artery Disease-associated-Heart Failure', 'Memory Disorders-use-Death', 'Cholestasis-induce-Chemical and Drug Induced Liver Injury', 'Cholestasis-include-Mitochondrial Diseases', 'Cholestasis-lead-Mitochondrial Diseases', 'Cholestasis-include-Death', 'Cholestasis-lead-Death', 'Cholestasis-include-Fibrosis', 'Cholestasis-induce-Fibrosis', 'Neurodegenerative Diseases-positioned-Death', 'Chemical and Drug Induced Liver Injury-include-Mitochondrial Diseases', 'Death-include-Chemical and Drug Induced Liver Injury', 'Fibrosis-include-Chemical and Drug Induced Liver Injury', 'Mitochondrial Diseases-lead-Death', 'Liver Failure-mitigate-Fatty Liver', 'Acute Disease-present-Hereditary Breast and Ovarian Cancer Syndrome', 'Parkinson Disease, Secondary-associated-Hip Fractures', 'Hip Fractures-associated-Parkinson Disease, Secondary', 'Parkinson Disease, Secondary-present-Hereditary Breast and Ovarian Cancer Syndrome', 'Parkinson Disease, Secondary-consider-Parkinson Disease', 'Inflammation-increase-Neurodegenerative Diseases', 'Mitochondrial Diseases-increase-Neurodegenerative Diseases', 'Abnormalities, Drug-Induced-affect-Neoplasms', 'Sarcopenia-seen-Wasting Syndrome', 'Osteosarcoma-diagnosed-Neoplasms', 'Fragile X Syndrome-target-Fractures, Bone', 'Pain-identified-Gait Disorders, Neurologic', 'Cardiac Output, Low-identified-Gait Disorders, Neurologic', 'Cardiac Output, Low-fall-Gait Disorders, Neurologic', 'Chronic Disease-affect-Alzheimer Disease', 'Chronic Disease-develop-Alzheimer Disease', 'Communicable Diseases-manifest-Death', 'Infections-related-Diabetes Mellitus', 'Infections-related-Hypertension', 'Infections-related-Pulmonary Disease, Chronic Obstructive', 'Neurodegenerative Diseases-distinguish-Amyotrophic Lateral Sclerosis', 'Renal Insufficiency, Chronic-accumulate-Death', 'Diabetes Mellitus, Type 2-take-Diabetes Mellitus', 'Alzheimer Disease-represent-Dementia', 'Obesity-associated-Osteoporosis', 'Osteoporosis-associated-Obesity', 'Sarcopenia-become-Chronic Disease', 'Obesity-relate-Metabolic Syndrome', 'Sarcopenia-happen-Chronic Disease', 'Sarcopenia-happen-Renal Insufficiency, Chronic', 'Sarcopenia-become-Death', 'Muscle Weakness-involve-Fasciculation', 'Hamartoma Syndrome, Multiple-accelerate-Prostatic Intraepithelial Neoplasia', 'Prostatic Neoplasms-remain-Neoplasms', 'Precancerous Conditions-include-Prostatic Neoplasms', 'Precancerous Conditions-include-Neoplasms', 'Prostatic Intraepithelial Neoplasia-find-Neoplasms', 'Communicable Diseases-remain-Adrenal Insufficiency', 'Olfaction Disorders-suggested-Parkinson Disease', 'Nutrition Disorders-predict-Death', 'Dementia-report-Stroke', 'Obesity-delay-Neoplasms', 'Parasomnias-treated-REM Sleep Behavior Disorder', 'Neoplasms-impact-Infections', 'Hyperthyroidism-found-Tachycardia', 'Hyperthyroidism-develop-Heart Failure', 'Chronic Disease-include-Neoplasms', 'Wounds and Injuries-associated-Vascular System Injuries', 'Vascular System Injuries-associated-Wounds and Injuries', 'Glucose Metabolism Disorders-identify-Delirium', 'Sarcopenia-prevent-Cardiovascular Diseases', 'Giant Cell Arteritis-misdiagnosed-Polymyalgia Rheumatica', 'Giant Cell Arteritis-misdiagnosed-Arthritis, Rheumatoid', 'Peripheral Nervous System Diseases-include-Radiculopathy', 'Arteritis-include-Radiculopathy', 'Headache Disorders, Secondary-compare-Migraine Disorders', 'Headache Disorders, Secondary-suffer-Migraine Disorders', 'Headache Disorders, Secondary-compare-Headache', 'Headache Disorders, Secondary-suffer-Headache', 'Dementia-related-Pain', 'Dysphonia-detect-Parkinson Disease', 'Hyperhomocysteinemia-evaluate-Renal Insufficiency, Chronic', 'Hyperuricemia-evaluate-Renal Insufficiency, Chronic', 'Thromboembolism-associated-Atherosclerosis', 'Atherosclerosis-associated-Thromboembolism', 'Thromboembolism-affect-Cerebral Infarction', 'Cerebral Infarction-affect-Atherosclerosis', 'Pneumonia-base-Inflammatory Bowel Diseases', 'Pneumonia-estimate-Inflammatory Bowel Diseases', 'Death-base-Inflammatory Bowel Diseases', 'Death-estimate-Inflammatory Bowel Diseases', 'Acute Coronary Syndrome-reduce-Hemorrhage', 'Sarcopenia-occur-Arthritis, Rheumatoid', 'Atrophy-associated-Parkinson Disease', 'Parkinson Disease-associated-Atrophy', 'Inflammation-reduce-Severe Acute Respiratory Syndrome', 'Epilepsies, Myoclonic-disrupt-Parkinsonian Disorders', 'Hyperglycemia-alter-Inflammation', 'Hyperglycemia-alter-Neoplasms, Nerve Tissue', 'Diabetes Mellitus-reveal-Inflammation', 'Cardiovascular Diseases-compare-Coronary Artery Disease', 'Dementia-receive-Neoplasms', 'Skin Diseases-manifest-Drug-Related Side Effects and Adverse Reactions', 'Skin Diseases-manifest-Hemorrhage', 'Drug-Related Side Effects and Adverse Reactions-manifest-Hemorrhage', 'Hemorrhage-develop-Skin Diseases', 'Hemorrhage-develop-Acute Kidney Injury', 'Neoplasms-lead-Fistula', 'Deglutition Disorders-manifested-Constriction, Pathologic', 'Gastrointestinal Hemorrhage-presented-Fistula', 'Atrophy-relate-Parkinson Disease', 'Atrophy-computed-Parkinson Disease', 'Death-undergo-Hematoma, Subdural', 'Infections-cause-Weight Loss', 'Wounds and Injuries-control-Death', 'Low Back Pain-develop-Fractures, Compression', 'Tuberculosis-suggest-Infections', 'Diabetes Mellitus, Type 2-prescribe-Diabetes Mellitus', 'Heart Diseases-related-Heart Failure', 'Neoplasms-control-Neoplasm Metastasis', 'Retinal Diseases-cause-Vision Disorders', 'Nervous System Diseases-recover-Spinal Cord Injuries', 'Learning Disabilities-apply-Metabolic Syndrome', 'Learning Disabilities-associated-Metabolic Syndrome', 'Metabolic Syndrome-associated-Learning Disabilities', 'Metabolic Syndrome-investigate-Learning Disabilities', 'Metabolic Syndrome-use-Learning Disabilities', 'Tachycardia-become-Heart Diseases', 'Tachycardia-become-Syncope', 'Tachycardia-become-Chest Pain', 'Tachycardia-become-Dyspnea', 'Proteostasis Deficiencies-play-Carcinogenesis', 'Mitochondrial Diseases-play-Carcinogenesis', 'Dysbiosis-associated-Pruritus', 'Pruritus-associated-Dysbiosis', 'Diabetes Mellitus, Type 2-associated-Hearing Loss', 'Hearing Loss-associated-Diabetes Mellitus, Type 2', 'Communicable Diseases-live-Cardiovascular Diseases', 'Death-caused-Heart Diseases', 'Death-caused-Neoplasms', 'Cerebral Intraventricular Hemorrhage-associated-Death', 'Death-associated-Cerebral Intraventricular Hemorrhage', 'Heart Failure-represent-Death', 'Heart Failure-represent-Diabetes Mellitus', 'Cardiovascular Diseases-represent-Diabetes Mellitus', 'Edema-prevent-Airway Obstruction', 'Myotonic Dystrophy-compare-Femoral Neck Fractures', 'Hematologic Neoplasms-accumulated-Lymphoma', 'Hematologic Neoplasms-accumulated-Leukemia', 'Death-base-Aneurysm', 'Cardiomyopathy, Hypertrophic-prevent-Death, Sudden', 'Cardiomyopathy, Hypertrophic-reduce-Heart Failure', 'Death, Sudden-prevent-Heart Failure', 'Death, Sudden-reduce-Death', 'Heart Diseases-reduce-Death', 'Wounds and Injuries-used-Brain Injuries, Traumatic', 'Wounds and Injuries-identify-Brain Injuries, Traumatic', 'Malnutrition-malnourished-Deglutition Disorders', 'Fatty Liver-include-Metabolic Diseases', 'Death-include-Blood Coagulation Disorders', 'Respiratory Insufficiency-characterized-Myasthenia Gravis', 'Death-predict-Anemia', 'Hypoxia-exacerbate-Inflammation', 'Hypoxia-enhance-Multiple Organ Failure', 'Hypoxia-lead-Death', 'Inflammation-enhance-Multiple Organ Failure', 'Inflammation-lead-Death', 'Multiple Organ Failure-lead-Death', 'Atrophy-associate-Memory Disorders', 'Memory Disorders-associate-Atrophy', 'Dementia-ascertain-Death', 'Arthralgia-based-Edema', 'Osteomyelitis-represent-Infections', 'Lung Diseases, Interstitial-base-Fibrosis', 'Diabetes Mellitus-follow-Hypertension', 'Death-develop-Respiratory Distress Syndrome', 'Death-develop-Acute Kidney Injury', 'Lymphedema-assessed-Leg Injuries', 'Lymphedema-assess-Edema', 'Lymphedema-estimate-Edema', 'Multiple Myeloma-explain-Pain', 'Cerebrovascular Disorders-contribute-Alzheimer Disease', 'Cerebrovascular Disorders-affect-Alzheimer Disease', 'Cerebrovascular Disorders-promote-Neurodegenerative Diseases', 'Alzheimer Disease-promote-Neurodegenerative Diseases', 'Periodontitis-implicate-Death', 'Joint Diseases-found-Hemochromatosis', 'Joint Diseases-found-Osteoarthritis', 'Hemochromatosis-include-Joint Diseases', 'Osteoarthritis-include-Joint Diseases', 'Sleep Apnea, Obstructive-include-Hypertension', 'Sleep Apnea, Obstructive-include-Skin Neoplasms', 'Sleep Apnea, Obstructive-include-Diabetes Mellitus', 'Chemical and Drug Induced Liver Injury-compare-Liver Failure', 'Neoplasms-target-Substance-Related Disorders', 'Drug-Related Side Effects and Adverse Reactions-apply-Malaria, Falciparum', 'Heart Arrest-provide-Neoplasms', 'Progeria-produce-Atherosclerosis', 'Progeria-produce-Joint Diseases', 'Alcoholism-associated-Drug Overdose', 'Drug Overdose-associated-Alcoholism', 'Fibrosis-abstain-Liver Diseases', 'Fibrosis-abstain-Alcoholism', 'Sleep Wake Disorders-change-Death', 'Sleep Initiation and Maintenance Disorders-include-Sleep Wake Disorders', 'Restless Legs Syndrome-include-Sleep Wake Disorders', 'Disorders of Excessive Somnolence-include-Sleep Wake Disorders', 'Arteriovenous Malformations-recognised-Intracranial Embolism', 'Pneumonia-lead-Critical Illness', 'Hypertension-discovered-Cerebral Infarction', 'Pulmonary Embolism-related-Arteriovenous Malformations', 'Cerebral Infarction-related-Arteriovenous Malformations', 'Seizures-fit-Neoplasms', 'Seizures-let-Drug-Related Side Effects and Adverse Reactions', 'Neoplasms-let-Drug-Related Side Effects and Adverse Reactions', 'CHARGE Syndrome-include-Atrial Fibrillation', 'CHARGE Syndrome-predict-Atrial Fibrillation', 'Infections-used-Death', 'Hypothermia-increase-Death', 'Hypothermia-increase-Hip Fractures', 'Hypertension-cause-Paresis', 'Stroke-cause-Paresis', 'Neoplasms-used-Glioma', 'Malnutrition-associated-Coronary Artery Disease', 'Coronary Artery Disease-associated-Malnutrition', 'Hearing Disorders-associated-Coronary Artery Disease', 'Coronary Artery Disease-associated-Hearing Disorders', 'Venous Thromboembolism-associated-Coronary Artery Disease', 'Coronary Artery Disease-associated-Venous Thromboembolism', 'Dystonia-describe-Alzheimer Disease', 'Dystonia-precipitate-Delirium', 'HIV Infections-live-Infections', 'Chromosome Aberrations-lead-Infertility, Female', 'Metabolic Syndrome-predict-Prostatic Neoplasms', 'Drug-Related Side Effects and Adverse Reactions-reduce-Death', 'Pulmonary Disease, Chronic Obstructive-exhibit-Metabolic Diseases', 'Malnutrition-enhance-Wounds and Injuries', 'Seizures-enhance-Wounds and Injuries', 'Neoplasms-enhance-Wounds and Injuries', 'Neoplasms-include-Drug-Related Side Effects and Adverse Reactions', 'Inflammation-establish-Osteoarthritis', 'Renal Insufficiency, Chronic-exacerbate-Sarcopenia', 'Malnutrition-exacerbate-Sarcopenia', 'Diabetes Mellitus-implicated-Alzheimer Disease', 'Fever-manifest-Meningitis', 'Fever-manifest-Arthritis', 'Fever-manifest-Chemical and Drug Induced Liver Injury', 'Fever-manifest-Discitis', 'Arthritis-mimic-Meningitis', 'Arthritis-mimic-Discitis', 'Arthritis-caused-Infections', 'Arthritis, Rheumatoid-mimic-Meningitis', 'Arthritis, Rheumatoid-mimic-Discitis', 'Arthritis, Rheumatoid-caused-Infections', 'Meningitis-found-Infections', 'Discitis-found-Infections', 'Memory Disorders-caused-Brain Diseases', 'Neurologic Manifestations-caused-Brain Diseases', 'Inflammation-triggered-Wounds and Injuries', 'Fibrosis-triggered-Wounds and Injuries', 'Infections-trigger-Bursitis', 'Wounds and Injuries-trigger-Bursitis', 'Diabetes Mellitus-associated-Bursitis', 'Bursitis-associated-Diabetes Mellitus', 'Parkinson Disease-associated-Bursitis', 'Bursitis-associated-Parkinson Disease', 'Nervous System Diseases-involve-Neurodegenerative Diseases', 'Alzheimer Disease-involve-Nervous System Diseases', 'Dementia-involve-Nervous System Diseases', 'Parkinson Disease-involve-Nervous System Diseases', 'Epilepsy-involve-Nervous System Diseases', 'Migraine Disorders-involve-Nervous System Diseases', 'Neurodegenerative Diseases-involve-Epilepsy', 'Immunologic Deficiency Syndromes-linked-Hyperhomocysteinemia', 'Immunologic Deficiency Syndromes-linked-Cerebrovascular Disorders', 'Frailty-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-Frailty', 'Immunologic Deficiency Syndromes-linked-Dementia, Vascular', 'Dementia, Vascular-include-Cerebrovascular Disorders', 'Thromboembolism-associated-Aortic Arch Syndromes', 'Aortic Arch Syndromes-associated-Thromboembolism', 'Thromboembolism-associated-Calcinosis', 'Calcinosis-associated-Thromboembolism', 'Thromboembolism-reduce-Aortic Arch Syndromes', 'Shock-occur-Frailty', 'Neoplasms-involved-Drug-Related Side Effects and Adverse Reactions', 'Hypothalamic Neoplasms-increase-Inflammation', 'Sleep Wake Disorders-increase-Inflammation', 'Eye Diseases-present-Neurodegenerative Diseases', 'Eye Diseases-present-Alzheimer Disease', 'Eye Diseases-present-Parkinson Disease', 'Eye Diseases-present-Death', 'Neurodegenerative Diseases-present-Alzheimer Disease', 'Neurodegenerative Diseases-present-Parkinson Disease', 'Neurodegenerative Diseases-account-Dementia', 'Neoplasms-develop-Cardiovascular Diseases', 'Neoplasms-develop-Metabolic Syndrome', 'Chronic Disease-seem-Neoplasms', 'Lipid Metabolism Disorders-attributed-Blood Platelet Disorders', 'Lipid Metabolism Disorders-attributed-Drug-Related Side Effects and Adverse Reactions', 'Parkinson Disease-associated-Ossification of Posterior Longitudinal Ligament', 'Ossification of Posterior Longitudinal Ligament-associated-Parkinson Disease', 'Inflammation-play-Dementia', 'Cerebral Infarction-find-Neoplasms', 'Sleep Initiation and Maintenance Disorders-cope-Communicable Diseases', 'Sleep Initiation and Maintenance Disorders-result-Infertility, Female', 'Communicable Diseases-cope-Infertility, Female', 'Shock-associated-Death', 'Death-associated-Shock', 'Alzheimer Disease-face-Dementia', 'Sarcopenia-prevent-Metabolic Syndrome', 'Arthritis, Infectious-defined-Infections', 'Arthritis, Infectious-defined-Osteomyelitis', 'Diabetes Mellitus-associated-Muscular Atrophy', 'Muscular Atrophy-associated-Diabetes Mellitus', 'Chronic Disease-associated-Muscular Atrophy', 'Muscular Atrophy-associated-Chronic Disease', 'Liver Diseases-defined-Fibrosis', 'Liver Diseases-classify-Fibrosis', 'Liver Diseases-increase-Death', 'Neoplasms-contribute-Inflammation', 'Chronic Disease-affect-Parkinson Disease', 'Rupture-enriched-Neoplasms', 'Pneumonia-complicated-Multiple Organ Failure', 'Pleural Effusion-complicated-Multiple Organ Failure', 'Nervous System Diseases-lead-Alzheimer Disease', 'Infections-cause-Alzheimer Disease', 'Infections-recognized-Stomach Neoplasms', 'Stroke-get-Death', 'Genetic Diseases, Inborn-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-Genetic Diseases, Inborn', 'Genetic Diseases, Inborn-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-Genetic Diseases, Inborn', 'Ovarian Diseases-decrease-Aneuploidy', 'Neoplasms-assess-Prostatic Neoplasms', 'Neurodegenerative Diseases-caused-Wounds and Injuries', 'Intervertebral Disc Degeneration-considered-Low Back Pain', 'Neurodegenerative Diseases-considered-Low Back Pain', 'Sleep Apnea Syndromes-include-Sleep Wake Disorders', 'Apnea-lead-Coronary Artery Disease', 'Hypoxia-caused-Sleep Apnea Syndromes', 'Hypoxia-lead-Inflammation', 'Sleep Apnea Syndromes-lead-Inflammation', 'Death-compare-Arthritis, Rheumatoid', 'Arthritis, Rheumatoid-determined-Death', 'Neoplasms-associated-Arthritis, Rheumatoid', 'Arthritis, Rheumatoid-associated-Neoplasms', 'Death-exist-Hypertension', 'Death-exist-Hypokalemia', 'Death-exist-Heart Arrest', 'Atrial Fibrillation-exist-Hypertension', 'Atrial Fibrillation-exist-Hypokalemia', 'Atrial Fibrillation-exist-Heart Arrest', 'Death-remain-Dementia', 'Dementia-reported-Diabetes Mellitus', 'Coronavirus Infections-lead-Death', 'Renal Insufficiency, Chronic-characterised-Inflammation', 'Renal Insufficiency, Chronic-linked-Atherosclerosis', 'Choroidal Neovascularization-represent-Retinal Neovascularization', 'Sarcopenia-used-Coronary Artery Disease', 'Sarcopenia-predict-Coronary Artery Disease', 'Brain Injuries, Traumatic-caused-Wounds and Injuries', 'Hip Fractures-collect-Wounds and Injuries', 'Fractures, Bone-measure-Diabetes Mellitus, Type 2', 'Arthritis-associated-Fatigue', 'Fatigue-associated-Arthritis', 'Arthritis-associated-Diplopia', 'Diplopia-associated-Arthritis', 'Arthritis-develop-Diplopia', 'Fatigue-develop-Diplopia', 'Anemia, Hemolytic, Autoimmune-diagnose-Lupus Erythematosus, Systemic', 'Neurodegenerative Diseases-cover-Alzheimer Disease', 'Neurodegenerative Diseases-cover-Parkinson Disease, Secondary', 'Epilepsy-cover-Neurodegenerative Diseases', 'Alzheimer Disease-cause-Brain Damage, Chronic', 'Dementia-cause-Brain Damage, Chronic', 'Hearing Loss-linked-Dementia', 'Stomach Neoplasms-peak-Death', 'Progeria-occur-Death', 'Death-appear-Cardiovascular Diseases', 'Myocardial Infarction-demonstrate-Fibrosis', 'Periodontitis-characterized-Inflammation', 'Periodontitis-characterized-Alveolar Bone Loss', 'Periodontal Diseases-describe-Periodontitis', 'Periodontal Diseases-describe-Inflammation', 'Periodontal Diseases-induce-Inflammation', 'Periodontitis-describe-Inflammation', 'Coronavirus Infections-fall-Dementia', 'Chondrocalcinosis-compared-Gitelman Syndrome', 'Ulcer-cause-Pain', 'Ulcer-subjected-Tics', 'Fractures, Bone-identified-Hip Fractures', 'Fractures, Bone-include-Hip Fractures', 'Obesity, Maternal-linked-Diabetes, Gestational', 'Obesity-reduced-Calcinosis', 'Cardiovascular Diseases-include-Obesity', 'Kidney Diseases-remain-Death', 'Nervous System Diseases-associated-Neurodegenerative Diseases', 'Neurodegenerative Diseases-associated-Nervous System Diseases', 'Pneumonia-investigate-Parkinson Disease', 'Pneumonia-associated-Parkinson Disease', 'Parkinson Disease-associated-Pneumonia', 'Parkinson Disease-develop-Deglutition Disorders', 'Deglutition Disorders-associated-Pneumonia', 'Pneumonia-associated-Deglutition Disorders', 'Cerebrovascular Disorders-entwined-Alzheimer Disease', 'Cerebrovascular Disorders-contribute-Hypoxia', 'Alzheimer Disease-contribute-Hypoxia', 'Cerebral Small Vessel Diseases-discuss-Cardiovascular Diseases', 'Cerebral Small Vessel Diseases-discuss-Hypertension', 'Inflammation-discuss-Cardiovascular Diseases', 'Inflammation-discuss-Hypertension', 'Constriction, Pathologic-associated-Atrophy', 'Atrophy-associated-Constriction, Pathologic', 'Atrophy-mediate-Memory Disorders', 'Hallucinations-associated-Hearing Loss', 'Hearing Loss-associated-Hallucinations', 'Neurologic Manifestations-related-Brain Diseases', 'Sleep Wake Disorders-experience-Weight Gain', 'HIV Infections-associated-Death, Sudden, Cardiac', 'Death, Sudden, Cardiac-associated-HIV Infections', 'Sarcopenia-defined-Osteoporosis', 'Menstruation Disturbances-associated-Endometriosis', 'Endometriosis-associated-Menstruation Disturbances', 'Cardiovascular Diseases-elevate-Muscular Atrophy', 'Cardiovascular Diseases-elevate-Sarcopenia', 'Muscular Atrophy-result-Death', 'Fractures, Bone-suffer-Diabetes Mellitus', 'Fractures, Bone-associated-Uterine Inertia', 'Uterine Inertia-associated-Fractures, Bone', 'Lymphopenia-associated-Death', 'Death-associated-Lymphopenia', 'Diabetes Mellitus-confirmed-Hypotension', 'Heredodegenerative Disorders, Nervous System-lead-Infections', 'Heredodegenerative Disorders, Nervous System-lead-Inflammation', 'Heredodegenerative Disorders, Nervous System-lead-Metabolic Diseases', 'Chronic Disease-complete-Death', 'Emphysema-found-Tuberculosis', 'Pneumonia-refer-Inflammation', 'Lupus Erythematosus, Systemic-regulate-Autoimmune Diseases', 'Arthritis, Rheumatoid-regulate-Autoimmune Diseases', 'Immunologic Deficiency Syndromes-occur-Malnutrition', 'Immunologic Deficiency Syndromes-occur-Metabolic Diseases', 'Immunologic Deficiency Syndromes-occur-Infections', 'Immunologic Deficiency Syndromes-occur-Neoplasms', 'Alzheimer Disease-relate-Dementia', 'Critical Illness-accelerate-Alcoholism', 'Vision Disorders-classified-Vision, Low', 'Vision Disorders-classified-Blindness', 'Werner Syndrome-develop-Neoplasms', 'Rothmund-Thomson Syndrome-develop-Neoplasms', 'Melanoma-lead-Death', 'Pigmentation Disorders-require-Melanoma', 'Pigmentation Disorders-require-Severe Acute Respiratory Syndrome', 'Pneumonia-suffer-Death', 'Infections-prevent-Cross Infection', 'Obesity-include-Renal Insufficiency', 'Chronic Disease-live-Death', 'Osteoporosis-found-Fractures, Bone', 'Neurotoxicity Syndromes-accumulate-Alzheimer Disease', 'Inflammation-regulate-Periodontal Diseases', 'Drug-Related Side Effects and Adverse Reactions-include-Alzheimer Disease', 'Heart Diseases-associated-Olfaction Disorders', 'Olfaction Disorders-associated-Heart Diseases', 'Heart Diseases-associated-Pain', 'Pain-associated-Heart Diseases', 'Respiratory Tract Diseases-associated-Inflammation', 'Inflammation-associated-Respiratory Tract Diseases', 'Seizures-distinguish-Adrenal Insufficiency', 'Myocardial Infarction-cause-Death', 'Proteostasis Deficiencies-linked-Neoplasms', 'Proteostasis Deficiencies-linked-Neurodegenerative Diseases', 'Eye Diseases-include-Coronaviridae Infections', 'Inflammation-associated-Nerve Degeneration', 'Nerve Degeneration-associated-Inflammation', 'Neurotoxicity Syndromes-known-Puberty, Delayed', 'Neurotoxicity Syndromes-delay-Puberty, Delayed', 'Sensation Disorders-follow-Muscle Weakness', 'Sensation Disorders-follow-Ataxia', 'Sensation Disorders-tingl-Ataxia', "Drug Hypersensitivity-result-Mikulicz' Disease", "Neoplasms-result-Mikulicz' Disease", 'Biliary Tract Diseases-associated-Neoplasms', 'Neoplasms-associated-Biliary Tract Diseases', 'Biliary Tract Diseases-associated-Drug Hypersensitivity', 'Drug Hypersensitivity-associated-Biliary Tract Diseases', 'Immunologic Deficiency Syndromes-prevent-Nerve Degeneration', 'Biliary Tract Diseases-associated-Vasculitis', 'Vasculitis-associated-Biliary Tract Diseases', 'Motor Neuron Disease-occur-Mandibular Nerve Injuries', 'Wallerian Degeneration-occur-Mandibular Nerve Injuries', 'Progeria-characterized-Cardiovascular Diseases', 'Infections-improve-Obesity', 'Chronic Disease-affect-Infections', 'Apnea-occur-Sleep Wake Disorders', 'Sleep Apnea Syndromes-occur-Sleep Wake Disorders', 'Alzheimer Disease-associated-Mitochondrial Diseases', 'Mitochondrial Diseases-associated-Alzheimer Disease', 'Neoplasm Metastasis-abandoned-Neoplasms', 'Glomerulonephritis-found-Renal Insufficiency', 'AIDS Arteritis, Central Nervous System-present-HIV Infections', 'Thrombosis-develop-Cushing Syndrome', 'Thrombosis-develop-Purpura Fulminans', 'Cushing Syndrome-complicate-Purpura Fulminans', 'Adenoma-diagnosed-Cushing Syndrome', 'Blood Coagulation Disorders-result-Venous Thromboembolism', 'Weight Loss-carried-Obesity', 'Bone Diseases, Metabolic-increase-Sarcopenia', 'Hypertension-associated-Cardiac Output, Low', 'Cardiac Output, Low-associated-Hypertension', 'Hypertension-fall-Cardiac Output, Low', 'Anemia-remain-Renal Insufficiency, Chronic', 'Nutrition Disorders-related-Anemia', 'Atherosclerosis-incite-Coronary Thrombosis', 'Hypertension-raise-Death', 'Obesity-raise-Death', 'Hyperglycemia-recruit-Hypertension', 'Hyperglycemia-known-Diabetes Mellitus', 'Hyperalgesia-appear-Mandibular Nerve Injuries', 'Hodgkin Disease-acquired-Seizures', 'Multiple Myeloma-acquired-Seizures', 'Werner Syndrome-include-Osteoporosis', 'Werner Syndrome-include-Atherosclerosis', 'Werner Syndrome-include-Diabetes Mellitus', 'Death-caused-Pancreatitis', 'Infections-drive-Death', 'Gastrointestinal Diseases-lead-Diarrhea', 'Hereditary Breast and Ovarian Cancer Syndrome-associate-Death', 'Death-associate-Hereditary Breast and Ovarian Cancer Syndrome', 'Stroke-tend-Breast Neoplasms', 'Leukoencephalopathies-relate-Alzheimer Disease', 'Dementia-suggest-Clostridium Infections', 'Renal Insufficiency, Chronic-exist-Clostridium Infections', 'Leukemia, Myelogenous, Chronic, BCR-ABL Positive-linked-Hematoma, Subdural', 'Headache-related-Wounds and Injuries', 'Inflammation-account-Fatigue', 'Neurologic Manifestations-cause-Heart Arrest', 'Asthma-become-Respiratory Tract Diseases', 'Dementia-stratify-Coronary Artery Disease', 'Fibromyalgia-characterized-Musculoskeletal Pain', 'Chronic Disease-characterized-Musculoskeletal Pain', 'Fibromyalgia-related-Sarcopenia', 'Machado-Joseph Disease-known-Neurodegenerative Diseases', 'Stroke-correlate-Death', 'Dementia-associated-Glucose Intolerance', 'Glucose Intolerance-associated-Dementia', 'Hypertension-reported-Low Back Pain', 'Hypertension-correlate-Low Back Pain', 'Infections-resemble-Sepsis', 'Infections-resemble-Pancreatitis', 'Hematologic Diseases-transition-Leukemia, Myeloid, Acute', 'Diabetes Mellitus-related-Rupture', 'Diabetes Mellitus-related-Atherosclerosis', 'Diabetes Mellitus-related-Thrombosis', 'Sleep Initiation and Maintenance Disorders-prevent-Inflammation', 'Weight Loss-prevent-Inflammation', 'Polyendocrinopathies, Autoimmune-lead-Death', 'Death-lead-Hypoparathyroidism', 'Death-lead-Diabetes Mellitus', 'Death-lead-Chemical and Drug Induced Liver Injury', 'Amyotrophic Lateral Sclerosis-include-Death', 'Diabetes Mellitus-live-Obesity', 'Death-live-Diabetes Mellitus', 'Death-include-Cerebrovascular Disorders', 'Chronic Disease-experience-Death', 'Death-include-Hyperkalemia', 'Death-underlie-Coronary Artery Disease', 'Aneuploidy-learne-Learning Disabilities', 'Death-underlie-Cerebrovascular Disorders', 'Aneuploidy-learne-Movement Disorders', 'Learning Disabilities-learne-Movement Disorders', 'Death-underlie-Hyperkalemia', 'Neoplasms-associated-Arbovirus Infections', 'Arbovirus Infections-associated-Neoplasms', 'Arbovirus Infections-include-Carcinoma, Hepatocellular', 'Arbovirus Infections-associated-Vulvar Neoplasms', 'Vulvar Neoplasms-associated-Arbovirus Infections', 'Heart Arrest-lead-Shock, Hemorrhagic', 'Heart Arrest-lead-Wounds and Injuries', 'Heart Arrest-lead-Shock, Septic', 'Osteoporosis-diagnosed-Fractures, Bone', 'Multiple Myeloma-show-Xerostomia', 'Gingival Hemorrhage-check-Periodontal Diseases', 'Hypoglycemia-considered-Neoplasms', 'Hypoglycemia-considered-Hypopituitarism', 'Hypoglycemia-considered-Alcoholism', 'Hypoglycemia-considered-Renal Insufficiency', 'Hypoglycemia-considered-Sepsis', 'Inflammation-trigger-Infections', 'Obesity-caused-Inflammation', 'Obesity-lead-Metabolic Diseases', 'Obesity-lead-Neoplasms', 'Inflammation-lead-Metabolic Diseases', 'Inflammation-lead-Neoplasms', 'Peripheral Nervous System Diseases-assess-Breast Neoplasms', 'Peripheral Nervous System Diseases-assess-Neoplasms', 'Breast Neoplasms-followed-Neoplasms', 'Peripheral Nervous System Diseases-based-Sensation Disorders', 'Peripheral Nervous System Diseases-based-Neoplasms', 'Peripheral Nervous System Diseases-based-Neurotoxicity Syndromes', 'Progeria-focus-Glucosephosphate Dehydrogenase Deficiency', 'Atherosclerosis-include-Mastocytosis, Systemic', 'Chronic Disease-lead-Atrophy', 'Neoplasms-lead-Atrophy', 'Infections-lead-Atrophy', 'Muscular Atrophy-lead-Atrophy', 'Obesity-increase-Hypertension', 'Tooth Loss-associated-Periodontal Diseases', 'Periodontal Diseases-associated-Tooth Loss', 'Xerostomia-associated-Death', 'Death-associated-Xerostomia', 'Xerostomia-associated-Periodontal Diseases', 'Periodontal Diseases-associated-Xerostomia', 'Periodontal Diseases-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-Periodontal Diseases', 'Headache Disorders, Secondary-live-HIV Infections', 'Sarcopenia-undergo-Neoplasms', 'Sarcopenia-described-Diabetes Mellitus', 'Lung Diseases-increase-Pneumonia, Pneumocystis', 'Cough-coupled-Dyspnea', 'Cough-coupled-Muscle Weakness', 'Cough-coupled-Fever', 'Cough-coupled-Fatigue', 'Infections-contribute-Carcinogenesis', 'Infections-summarize-Neoplasms', 'Communicable Diseases-show-Ovarian Neoplasms', 'Inflammation-associated-Communicable Diseases', 'Communicable Diseases-associated-Inflammation', 'Communicable Diseases-show-Melanoma', 'Communicable Diseases-show-Neoplasms', 'Inflammation-suggested-Neoplasms', 'Communicable Diseases-associated-Infections', 'Infections-associated-Communicable Diseases', 'Communicable Diseases-suggested-Neoplasms', 'Communicable Diseases-show-Glioma', 'Communicable Diseases-show-Meningeal Neoplasms', 'Ovarian Neoplasms-associated-Infections', 'Infections-associated-Ovarian Neoplasms', 'Hypertension-evaluate-Cerebral Small Vessel Diseases', 'Melanoma-associated-Infections', 'Infections-associated-Melanoma', 'Neoplasms-associated-Infections', 'Infections-associated-Neoplasms', 'Infections-associated-Glioma', 'Glioma-associated-Infections', 'Infections-associated-Meningeal Neoplasms', 'Meningeal Neoplasms-associated-Infections', 'Alzheimer Disease-develop-Seizures', 'Epilepsy-determine-Seizures', 'Alzheimer Disease-transition-Seizures', 'Alzheimer Disease-seen-Seizures', 'Pain-report-Low Back Pain', 'Constipation-caused-Ocular Motility Disorders', 'Peroneal Neuropathies-exhibit-Uterine Cervicitis', 'Peroneal Neuropathies-characterized-Sarcopenia', 'Uterine Cervicitis-characterized-Sarcopenia', 'Peroneal Neuropathies-characterized-Muscular Diseases', 'Respiratory Tract Diseases-include-Chronic Disease', 'Death-increased-Chronic Disease', 'Iatrogenic Disease-associated-Taste Disorders', 'Taste Disorders-associated-Iatrogenic Disease', 'Arthritis, Psoriatic-reduce-Pain', 'Arthritis, Psoriatic-reduce-Arthralgia', 'Ventricular Remodeling-slow-Heart Failure', 'Diabetes Mellitus-compare-Heart Failure', 'Weight Loss-derived-Metabolic Diseases', 'Diabetes Mellitus-induce-Malnutrition', 'Malnutrition-associated-Renal Insufficiency, Chronic', 'Renal Insufficiency, Chronic-associated-Malnutrition', 'Precancerous Conditions-harbour-Neoplasms', 'Fractures, Open-associated-Taste Disorders', 'Taste Disorders-associated-Fractures, Open', 'Coronavirus Infections-caused-Diabetes Mellitus', 'Coronavirus Infections-caused-Hypertension', 'Sleep Wake Disorders-control-Tinnitus', 'Coronavirus Infections-caused-Obesity', 'Neurologic Manifestations-caused-Diabetes Mellitus', 'Neurologic Manifestations-caused-Hypertension', 'Neurologic Manifestations-caused-Obesity', 'Diabetes Mellitus-caused-Thromboembolism', 'Hypertension-caused-Thromboembolism', 'Obesity-caused-Thromboembolism', 'Neoplasms-associated-Delirium', 'Delirium-associated-Neoplasms', 'Gait Disorders, Neurologic-fall-Cardiac Output, Low', 'Neoplasms-suspected-Precancerous Conditions', 'Colorectal Neoplasms-followed-Stomach Neoplasms', 'Death-followed-Stomach Neoplasms', 'Cardiovascular Diseases-emerging-Respiratory Tract Diseases', 'Neoplasms-followed-Stomach Neoplasms', 'Microvascular Angina-differentiate-Respiratory Tract Diseases', 'Microvascular Angina-differentiate-Cardiovascular Diseases', 'Microvascular Angina-bring-Myocardial Infarction', 'HIV Infections-live-Opportunistic Infections', 'Hypertrophy-contribute-Calcinosis', 'Osteoarthritis-promote-Hypertrophy', 'Hemolytic-Uremic Syndrome-associated-Graft vs Host Disease', 'Graft vs Host Disease-associated-Hemolytic-Uremic Syndrome', 'Neoplasms-range-Neurodegenerative Diseases', 'Neoplasms-range-Mitochondrial Diseases', 'Obesity-characterized-Inflammation', 'Pancreatitis-enhanced-Sphincter of Oddi Dysfunction', 'Mitochondrial Diseases-contribute-Infections', 'Renal Insufficiency, Chronic-associated-Dementia', 'Dementia-associated-Renal Insufficiency, Chronic', 'Urinary Incontinence-associated-Dementia', 'Dementia-associated-Urinary Incontinence', 'Cross Infection-predict-Hip Fractures', 'Death-increase-Cerebrovascular Disorders', 'Death-increase-Kidney Diseases', 'Infections-transform-Acquired Immunodeficiency Syndrome', 'Metabolic Syndrome-investigate-Acute Coronary Syndrome', 'Asthma-associated-Critical Illness', 'Critical Illness-associated-Asthma', 'Fever-associated-Critical Illness', 'Critical Illness-associated-Fever', 'Myelodysplastic Syndromes-account-Neoplastic Syndromes, Hereditary', 'Leukemia, Myeloid, Acute-inherit-Neoplastic Syndromes, Hereditary', 'Muscular Diseases-replace-Sarcopenia', 'Respiratory Tract Diseases-cause-Infections', 'Diabetes Mellitus-affected-Pneumonia', 'Diabetes Mellitus-develop-Headache Disorders, Secondary', 'Pneumonia-develop-Headache Disorders, Secondary', 'Breast Neoplasms-determine-Neoplasms', 'Neoplasms-occur-Breast Neoplasms', 'Peripheral Nervous System Diseases-associated-Hypotension', 'Hypotension-associated-Peripheral Nervous System Diseases', 'Limb Deformities, Congenital-associated-Hypotension', 'Hypotension-associated-Limb Deformities, Congenital', 'Bone Diseases-increase-Fractures, Bone', 'Osteoporosis-involve-Atrophy', 'Pain-moderate-Arthritis', 'Neoplasm Metastasis-related-Death', 'Cardiovascular Diseases-based-Death', 'Prostatic Hyperplasia-linked-Inflammation', 'Prostatic Neoplasms-linked-Inflammation', 'Edema-follow-Pain', 'Edema-follow-Foot Ulcer', 'Respiratory Tract Diseases-investigate-Death', 'Obesity-determined-Chronic Disease', 'Obesity-associate-Death', 'Death-associate-Obesity', 'Chronic Disease-associate-Death', 'Death-associate-Chronic Disease', 'Plaque, Atherosclerotic-counteract-Atherosclerosis', 'Pneumonia, Aspiration-extend-Death', 'Deglutition Disorders-associate-Death', 'Death-associate-Deglutition Disorders', 'Deglutition Disorders-associate-Pneumonia, Aspiration', 'Pneumonia, Aspiration-associate-Deglutition Disorders', 'Inflammation-caused-Infections', 'Infections-confer-Seizures', 'Atherosclerosis-increase-Cardiovascular Diseases', 'Heart Failure-increase-Cardiovascular Diseases', 'Dry Eye Syndromes-apply-Xerostomia', "Dry Eye Syndromes-apply-Sjogren's Syndrome", "Dry Eye Syndromes-occur-Sjogren's Syndrome", "Xerostomia-occur-Sjogren's Syndrome", 'Dysbiosis-characterize-Inflammatory Bowel Diseases', 'Dysbiosis-promote-Inflammation', 'Dysbiosis-up-regulate-Sarcopenia', 'Inflammatory Bowel Diseases-promote-Inflammation', 'Inflammatory Bowel Diseases-suffer-Sarcopenia', 'Inflammatory Bowel Diseases-up-regulate-Sarcopenia', 'Inflammation-up-regulate-Sarcopenia', 'Sarcopenia-related-Inflammatory Bowel Diseases', 'Olfaction Disorders-seen-Parkinson Disease', 'Olfaction Disorders-seen-Alzheimer Disease', 'Muscular Diseases-occur-Neoplasms', 'Muscular Diseases-associated-Cachexia', 'Cachexia-associated-Muscular Diseases', 'Sarcopenia-characterized-Atrophy', 'Sarcopenia-appear-Cachexia', 'Atrophy-appear-Cachexia', 'Sarcopenia-seem-Cachexia', 'Sarcopenia-seem-Neoplasms', 'Inflammation-appear-Cachexia', 'Hemorrhage-increase-Rupture', 'Gastrointestinal Stromal Tumors-increase-Neoplasms', 'Gastrointestinal Stromal Tumors-increase-Rupture', 'Multiple Sclerosis-increase-Infections', 'Fatty Liver-enhance-Metabolic Syndrome', 'Neurodegenerative Diseases-include-Atrophy', 'Neurodegenerative Diseases-include-Supranuclear Palsy, Progressive', 'Neurodegenerative Diseases-include-Huntington Disease', 'Neurodegenerative Diseases-characterised-Nerve Degeneration', 'Necrosis-caused-Aneurysm', 'Necrosis-caused-Duodenal Diseases', 'Necrosis-cause-Gastric Outlet Obstruction', 'Aneurysm-cause-Gastric Outlet Obstruction', 'Duodenal Diseases-cause-Gastric Outlet Obstruction', 'Infections-make-Death', 'Nervous System Diseases-become-Death', 'Death-ensue-Pulmonary Atresia', 'Deglutition Disorders-thought-Death', 'Deglutition Disorders-thought-Parkinson Disease', 'Lymphoma-followed-Carcinoma, Adenoid Cystic', 'Lymphoma-include-Lymphoproliferative Disorders', 'Lymphoproliferative Disorders-include-Orbital Neoplasms', 'Lymphoproliferative Disorders-form-Orbital Neoplasms', 'Lymphoma-form-Orbital Neoplasms', 'Osteoporosis-pertain-Ankle Fractures', 'Hemorrhage-defined-Amenorrhea', 'Dementia, Vascular-include-Neurodegenerative Diseases', 'Bisphosphonate-Associated Osteonecrosis of the Jaw-prevent-Fractures, Bone', 'Sleep Apnea, Obstructive-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-Sleep Apnea, Obstructive', 'Death-prevent-Blood Coagulation Disorders', 'Death-prevent-Leukemia, Promyelocytic, Acute', 'Leukemia, Promyelocytic, Acute-include-Blood Coagulation Disorders', 'Leukemia, Promyelocytic, Acute-develop-Blood Coagulation Disorders', 'Anemia, Sickle Cell-related-Dysbiosis', 'Mycoses-reported-Onychomycosis', 'Diabetes Mellitus-reported-Onychomycosis', 'Pulmonary Disease, Chronic Obstructive-induce-Inflammation', 'Pulmonary Disease, Chronic Obstructive-induce-Hypoxia', 'Drug-Related Side Effects and Adverse Reactions-ameliorate-Progeria', 'Neurodegenerative Diseases-constitute-Blindness', 'Aging, Premature-lead-Death', 'Hypoxia-linked-Inflammation', 'Mitochondrial Diseases-linked-Inflammation', 'Neurodegenerative Diseases-activate-Inflammation', 'Infections-associated-Heredodegenerative Disorders, Nervous System', 'Heredodegenerative Disorders, Nervous System-associated-Infections', 'Infections-appear-Alzheimer Disease', 'Heredodegenerative Disorders, Nervous System-appear-Alzheimer Disease', 'Fractures, Stress-result-Bone Diseases', 'Fractures, Stress-include-Fatigue', 'Bone Diseases-include-Fatigue', 'Bone Diseases-include-Fractures, Stress', 'Chronic Disease-seen-Hypertension', 'Fractures, Stress-seen-Osteoporosis', 'Hypertension-seen-Diabetes Mellitus', 'Sarcopenia-related-Chronic Disease', 'Inflammation-reduce-Death', 'Femoral Neck Fractures-treat-Death', 'Femoral Neck Fractures-result-Death', 'Hypoproteinemia-predict-Death', 'Hypertension-identified-Death', 'Renal Insufficiency, Chronic-identified-Death', 'Hypoproteinemia-identified-Death', 'Hypoproteinemia-associated-Death', 'Death-associated-Hypoproteinemia', 'Ossification of Posterior Longitudinal Ligament-stratified-Ventricular Fibrillation', 'Glaucoma-associated-Ventricular Fibrillation', 'Ventricular Fibrillation-associated-Glaucoma', 'Fractures, Bone-account-Death', 'Hearing Loss-associated-Tinnitus', 'Tinnitus-associated-Hearing Loss', 'Hearing Loss-associated-Hyperacusis', 'Hyperacusis-associated-Hearing Loss', 'Tinnitus-associated-Hyperacusis', 'Hyperacusis-associated-Tinnitus', 'Migraine Disorders-co-occur-Gastrointestinal Diseases', 'Diabetes Mellitus-consider-Coronary Artery Disease', 'Inflammation-play-Tauopathies', 'Dementia-include-Tauopathies', 'Bone Neoplasms-estimated-Fractures, Bone', 'Kyphosis-affect-Urinary Incontinence, Stress', 'Hearing Loss-include-Labyrinth Diseases', 'Hearing Loss-associated-Labyrinth Diseases', 'Labyrinth Diseases-associated-Hearing Loss', 'Hearing Loss-associated-Mastocytosis, Systemic', 'Mastocytosis, Systemic-associated-Hearing Loss', 'Labyrinth Diseases-associated-Mastocytosis, Systemic', 'Mastocytosis, Systemic-associated-Labyrinth Diseases', 'Pruritus-characterized-Exanthema', 'Brain Diseases-play-Infections', 'Fractures, Bone-follow-Wounds and Injuries', 'Cardiovascular Diseases-undergo-Angina, Stable', 'Cardiovascular Diseases-associated-Dyspnea', 'Dyspnea-associated-Cardiovascular Diseases', 'Angina, Stable-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-Angina, Stable', 'Cardiovascular Diseases-exclude-Angina, Stable', 'Infections-associated-Inflammation', 'Inflammation-associated-Infections', 'Aortic Valve Stenosis-become-Heart Valve Diseases', 'Aortic Valve Stenosis-assess-Inflammation', 'Disseminated Intravascular Coagulation-complicate-Sepsis', 'Disseminated Intravascular Coagulation-worsen-Death', 'Sepsis-worsen-Death', 'Death-improve-Sepsis', 'Obesity-predicted-Hypertension', 'Cardio-Renal Syndrome-occur-Heart Failure', 'Essential Tremor-associated-Death', 'Death-associated-Essential Tremor', 'Anterior Compartment Syndrome-compare-Tendinopathy', 'Infections-associated-Tuberculosis', 'Tuberculosis-associated-Infections', 'Respiratory Insufficiency-observed-Sarcopenia', 'Neoplasms-associated-Epilepsy', 'Epilepsy-associated-Neoplasms', 'Venous Thromboembolism-diagnosed-Astrocytoma', 'Astrocytoma-associated-Venous Thromboembolism', 'Venous Thromboembolism-associated-Astrocytoma', 'Fractures, Bone-convey-Death', 'Rib Fractures-induced-Wounds and Injuries', 'Takotsubo Cardiomyopathy-report-Chest Pain', 'Takotsubo Cardiomyopathy-report-Dyspnea', 'Takotsubo Cardiomyopathy-report-Fatigue', 'Wounds and Injuries-develop-Sepsis', 'Sepsis-obtained-Wounds and Injuries', 'Sepsis-develop-Wounds and Injuries', 'Alzheimer Disease-suggested-Chronobiology Disorders', 'Cerebrovascular Disorders-include-Multiple Organ Failure', 'Hypotension-result-Seizures', 'Dementia-increase-Nervous System Diseases', 'Microvascular Angina-favor-Myocardial Infarction', 'Tibial Meniscus Injuries-occur-Thrombosis', 'Tibial Meniscus Injuries-occur-Venous Thrombosis', 'Alzheimer Disease-discriminate-Dementia', 'Heart Valve Diseases-increase-Hypertension', 'Heart Valve Diseases-increase-Renal Insufficiency, Chronic', 'Hypertension-correlated-Heart Valve Diseases', 'Death-reduce-Aneurysm', 'Hemorrhage-reduce-Aneurysm', 'Sarcopenia-defined-Non-alcoholic Fatty Liver Disease', 'Adenomatous Polyposis Coli-become-Pancreatic Neoplasms', 'Pancreatic Neoplasms-suffer-Enteritis', 'Pancreatic Neoplasms-categorized-Neoplasm Metastasis', 'Dihydropyrimidine Dehydrogenase Deficiency-contribute-Enteritis', 'Pain-manage-Dementia', 'Pain-considered-Dementia', 'Memory Disorders-consist-Cerebral Small Vessel Diseases', 'Neoplasms-prepared-Dementia', 'Death-decrease-Infections', 'Cardiomyopathies-depend-Death', 'Infarction-depend-Death', 'Coronary Artery Disease-associated-Hypoxia', 'Hypoxia-associated-Coronary Artery Disease', 'Coronary Artery Disease-associated-Tachycardia', 'Tachycardia-associated-Coronary Artery Disease', 'Coronary Artery Disease-associated-Acute Kidney Injury', 'Acute Kidney Injury-associated-Coronary Artery Disease', 'Coronary Artery Disease-associated-Infections', 'Infections-associated-Coronary Artery Disease', 'Nerve Degeneration-play-Sarcopenia', 'Myocardial Infarction-associated-Acute Kidney Injury', 'Acute Kidney Injury-associated-Myocardial Infarction', 'Myocardial Infarction-associated-Shock', 'Shock-associated-Myocardial Infarction', 'Death-comprise-Heart Failure', 'End Stage Liver Disease-associated-Death', 'Death-associated-End Stage Liver Disease', 'Epilepsy-measure-Stroke', 'Cardiovascular Diseases-measure-Stroke', 'Cardiovascular Diseases-remain-Peripheral Vascular Diseases', 'Cardiovascular Diseases-remain-Epilepsy', 'Peripheral Vascular Diseases-remain-Epilepsy', 'Stroke-account-Cardiovascular Diseases', 'Aneurysm-differ-Cardiovascular Diseases', 'Epilepsy-differ-Cardiovascular Diseases', 'Cardiovascular Diseases-defined-Thrombosis', 'Hemorrhage-associated-Aneurysm', 'Aneurysm-associated-Hemorrhage', 'Hemorrhage-associated-Neurodegenerative Diseases', 'Neurodegenerative Diseases-associated-Hemorrhage', 'Kidney Diseases-associated-HIV Infections', 'HIV Infections-associated-Kidney Diseases', 'Fractures, Bone-correlated-Muscular Dystrophy, Duchenne', 'Bone Diseases, Metabolic-show-Muscular Dystrophy, Duchenne', 'Fatigue-associated-Multiple Sclerosis', 'Multiple Sclerosis-associated-Fatigue', 'Fatigue-understood-Multiple Sclerosis', 'Fatigue-compare-Multiple Sclerosis', 'Fatigue-associated-Sleep Wake Disorders', 'Sleep Wake Disorders-associated-Fatigue', 'Hip Fractures-fall-Heart Arrest', 'Fractures, Bone-underlie-Chronic Disease', 'Sphingolipidoses-underscore-Osteoporosis', 'Chronic Disease-prompt-Fragile X Syndrome', 'Chronic Disease-prompt-Muscular Dystrophy, Duchenne', 'Osteoporosis-prevent-Osteoporotic Fractures', 'Osteoporosis-characterized-Osteoporotic Fractures', 'Mastocytosis, Systemic-characterized-Osteoporotic Fractures', 'Neurologic Manifestations-affect-Huntington Disease', 'Hematoma-predict-Death', 'Hematoma-predict-Hematoma, Subdural', 'Hematoma-predict-Wounds and Injuries', 'Hematoma, Subdural-predict-Wounds and Injuries', 'Myocardial Infarction-analyzed-Hypertension', 'Stroke-analyzed-Hypertension', 'Death-analyzed-Hypertension', 'Cartilage Diseases-protect-Osteoarthritis', 'Alzheimer Disease-distinguish-Dementia', 'Blister-associated-Colorectal Neoplasms', 'Colorectal Neoplasms-associated-Blister', 'Dementia-followed-Pain', 'Delirium-diagnosed-Deglutition Disorders', 'Nerve Degeneration-reported-Lewy Body Disease', 'Immunologic Deficiency Syndromes-contribute-Alzheimer Disease', 'Immunologic Deficiency Syndromes-induce-Nerve Degeneration', 'Alzheimer Disease-induce-Nerve Degeneration', 'Neurosyphilis-associated-Inflammation', 'Inflammation-associated-Neurosyphilis', 'Inflammation-expected-Diffuse Neurofibrillary Tangles with Calcification', 'Neurodegenerative Diseases-provide-Nervous System Diseases', 'Neurodegenerative Diseases-provide-Encephalitis', 'Neurodegenerative Diseases-associated-Encephalitis', 'Encephalitis-associated-Neurodegenerative Diseases', 'Infections-associated-Encephalitis', 'Encephalitis-associated-Infections', 'Infections-associated-Neurosyphilis', 'Neurosyphilis-associated-Infections', 'Inflammation-associated-Encephalitis', 'Encephalitis-associated-Inflammation', 'Psychoses, Substance-Induced-related-Dementia', 'Inflammation-contribute-Obesity', 'Ulcer-lead-Death', 'Thromboembolism-lead-Death', 'Obesity-drive-Inflammation', 'Drug-Related Side Effects and Adverse Reactions-reinforce-Inflammation', 'Dysbiosis-characterized-Inflammation', 'Primary Ovarian Insufficiency-apply-Infertility, Female', 'Death-expected-Infections', 'Autoimmune Diseases-coupled-Obesity', 'Drug Hypersensitivity-coupled-Obesity', 'Inflammation-associated-Cerebral Infarction', 'Cerebral Infarction-associated-Inflammation', 'Hip Fractures-observed-Wounds and Injuries', 'Pain-applied-Compartment Syndromes', 'Leukoaraiosis-diagnosed-Infarction', 'Leukoaraiosis-delineate-Infarction', 'Leukoaraiosis-show-Diabetes Mellitus', 'Leukoaraiosis-show-Hypertension', 'Leukoaraiosis-show-Coronary Artery Disease', 'Leukoaraiosis-show-Stroke', 'Osteoarthritis-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-Osteoarthritis', 'Wounds and Injuries-encounter-Tooth Avulsion', 'Alzheimer Disease-surrounded-Plaque, Amyloid', 'Infections-disabling-Skin Diseases', 'Arthralgia-result-Rheumatic Fever', 'Malnutrition-identify-Infections', 'Neurologic Manifestations-present-Wounds and Injuries', 'Myoclonus-present-Wounds and Injuries', 'Death-related-Atrial Fibrillation', 'Polycystic Ovary Syndrome-link-Infertility, Female', 'Inflammation-implicated-Alzheimer Disease', 'Diabetes Mellitus-show-Erectile Dysfunction', 'Alzheimer Disease-mediate-Diabetes Mellitus', 'Cerebral Small Vessel Diseases-mediate-Diabetes Mellitus', 'Olfaction Disorders-associated-Communication Disorders', 'Communication Disorders-associated-Olfaction Disorders', 'Sarcopenia-develop-Chronic Disease', 'Hearing Loss-increase-Dementia', 'Alzheimer Disease-associated-Thoracic Outlet Syndrome', 'Thoracic Outlet Syndrome-associated-Alzheimer Disease', 'Dementia-associated-Thoracic Outlet Syndrome', 'Thoracic Outlet Syndrome-associated-Dementia', 'Neurodegenerative Diseases-associated-Thoracic Outlet Syndrome', 'Thoracic Outlet Syndrome-associated-Neurodegenerative Diseases', 'Metabolic Syndrome-derived-Obesity', 'Metabolic Syndrome-derived-Inflammation', 'Metabolic Syndrome-manifest-Drug-Related Side Effects and Adverse Reactions', 'Metabolic Syndrome-manifest-Death', 'Cardiomyopathies-associated-Alzheimer Disease', 'Alzheimer Disease-associated-Cardiomyopathies', 'Musculoskeletal Diseases-include-Chronic Disease', 'Metabolic Diseases-include-Chronic Disease', 'Dysbiosis-include-Chronic Disease', 'Proteostasis Deficiencies-constitute-Cockayne Syndrome', 'Cardiomyopathy, Hypertrophic-demonstrate-Fibrosis', 'Cardiomyopathy, Hypertrophic-demonstrate-Inflammation', 'Lipodystrophy-associated-Inflammation', 'Inflammation-associated-Lipodystrophy', 'Progeria-associated-Inflammation', 'Inflammation-associated-Progeria', 'Parkinson Disease-study-Memory Disorders', 'Neurodegenerative Diseases-induced-Hyperhomocysteinemia', 'Alzheimer Disease-suffer-Vision Disorders', 'Inflammation-accompanied-Hyperhomocysteinemia', 'Inflammation-highlight-Thoracic Outlet Syndrome', 'Inflammation-focus-Alzheimer Disease', 'Hyperhomocysteinemia-accompanied-Thoracic Outlet Syndrome', 'Hyperhomocysteinemia-focus-Alzheimer Disease', 'Thoracic Outlet Syndrome-focus-Alzheimer Disease', 'Neoplasms-lead-Hypoalbuminemia', 'Neoplasms-focused-Death', 'Neoplasms-reduced-Death', 'Neoplasms-lead-Edema', 'Dementia-compare-Hypertension', 'Cachexia-afflict-Neoplasms', 'Cachexia-afflict-Death', 'Neoplasms-afflict-Death', 'Mitral Valve Insufficiency-increase-Death', 'Inflammation-play-Delirium', 'Hereditary Breast and Ovarian Cancer Syndrome-known-Cryopyrin-Associated Periodic Syndromes', 'Neurologic Manifestations-caused-Stroke', 'Anemia-associated-Hemorrhage', 'Hemorrhage-associated-Anemia', 'Kidney Failure, Chronic-associated-Hemorrhage', 'Hemorrhage-associated-Kidney Failure, Chronic', 'Skin Neoplasms-include-Skin Diseases', 'Alzheimer Disease-detect-Seizures', 'Seizures-detect-Hyperkinesis', 'Diabetes Mellitus-affected-Neoplasms', 'Liver Diseases-affected-Neoplasms', 'Prostatitis-treat-Prostatic Hyperplasia', 'Prostatitis-include-Prostatic Hyperplasia', 'Prostatitis-compare-Prostatic Hyperplasia', 'Prostatitis-improve-Prostatic Hyperplasia', 'Prostatitis-lead-Prostatic Hyperplasia', 'Prostatitis-result-Prostatic Hyperplasia', 'Prostatitis-funded-Prostatic Hyperplasia', 'Denys-Drash Syndrome-decelerate-Renal Insufficiency, Chronic', 'Osteoporosis-extracted-Ovarian Neoplasms', 'Pain-rescue-Pain Insensitivity, Congenital', 'Pain-treat-HIV Infections', 'Parkinson Disease-demonstrate-Fatigue', 'Obesity-added-Infections', 'Hypogonadism-defined-Virilism', 'Hypogonadism-associated-Hypertension', 'Hypertension-associated-Hypogonadism', 'Infections-prevent-Death', 'Acute Kidney Injury-prevent-Death', 'Mitochondrial Diseases-identify-Sarcopenia', 'Death-related-Rheumatic Heart Disease', 'Joint Diseases-appreciate-Osteoarthritis', 'Malocclusion-use-Stroke', 'Hypertriglyceridemia-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-Hypertriglyceridemia', 'Infections-associated-Pancreatitis', 'Pancreatitis-associated-Infections', 'Diabetes Mellitus-elevate-Infections', 'Infections-cause-Coronavirus Infections', 'Infections-cause-Diabetes Mellitus', 'Infections-induce-Diabetes Mellitus', 'Osteoarthritis-associated-Sarcopenia', 'Sarcopenia-associated-Osteoarthritis', 'Osteoarthritis-increase-Sarcopenia', 'Osteoarthritis-appear-Obesity', 'Sarcopenia-appear-Obesity', 'Communicable Diseases-provide-Dementia', 'Communicable Diseases-provide-Infections', 'Dementia-occur-Infections', 'Communicable Diseases-identify-Dementia', 'Communicable Diseases-associated-Dementia', 'Dementia-associated-Communicable Diseases', 'Dementia-seen-Infections', 'Infections-combined-Communicable Diseases', 'Infections-combined-Dementia', 'Infections-driven-Inflammation', 'Communicable Diseases-driven-Inflammation', 'Dementia-driven-Inflammation', 'Infections-find-Dementia, Vascular', 'Sleep Initiation and Maintenance Disorders-increase-Death', 'Gait Disorders, Neurologic-manifested-Alzheimer Disease', 'Gait Disorders, Neurologic-used-Dementia', 'Gait Disorders, Neurologic-manifested-Dementia', 'Vertigo-fall-Cardiac Output, Low', 'Pain-associated-Sialic Acid Storage Disease', 'Sialic Acid Storage Disease-associated-Pain', 'Respiratory Tract Infections-reduce-Pulmonary Disease, Chronic Obstructive', 'Renal Insufficiency, Chronic-lead-Uremia', 'Renal Insufficiency, Chronic-lead-Anemia', 'Cerebrovascular Disorders-explain-Atrophy', 'Obesity, Abdominal-linked-Cardiovascular Abnormalities', 'Delirium-screened-Sarcopenia', 'Sarcopenia-suffer-Dementia', 'Dementia-diagnosed-Sarcopenia', 'Venous Insufficiency-indicate-Venous Thrombosis', 'Persistent Vegetative State-correlate-Inflammation', 'Venous Insufficiency-aggravate-Hypertension', 'Cataract-accompanied-Acidosis', 'Glucose Metabolism Disorders-test-Alzheimer Disease', 'Hearing Loss-hear-Sleep Initiation and Maintenance Disorders', 'Primary Myelofibrosis-feature-Bone Marrow Failure Disorders', 'Brain Injuries, Traumatic-proposed-Alzheimer Disease', 'Brain Injuries, Traumatic-associate-Neurogenic Inflammation', 'Neurogenic Inflammation-associate-Brain Injuries, Traumatic', 'Brain Injuries, Traumatic-associate-Nerve Degeneration', 'Nerve Degeneration-associate-Brain Injuries, Traumatic', 'Brain Injury, Chronic-proposed-Alzheimer Disease', 'Alzheimer Disease-release-Neurodegenerative Diseases', 'Common Cold-cause-Respiratory Distress Syndrome', 'Common Cold-resemble-Death', 'Fractures, Bone-influenced-Wounds and Injuries', 'Heart Diseases-treat-Cardiomegaly', 'Carcinogenesis-implicated-Brain Neoplasms', 'Carcinogenesis-play-Neoplasms', 'Death-occur-Pulmonary Embolism', 'Aortic Valve Stenosis-manifest-Cardiac Output, Low', 'Aortic Valve Stenosis-increasing-Heart Failure', 'Aortic Valve Stenosis-manifest-Death', 'Cardiac Output, Low-result-Heart Failure', 'Cardiac Output, Low-manifest-Death', 'Aortic Valve Stenosis-highlight-Heart Valve Diseases', 'Atherosclerosis-underlie-Inflammation', 'Inflammation-disentangle-Atherosclerosis', 'Inflammation-diagnosed-Metabolic Syndrome', 'Atherosclerosis-diagnosed-Metabolic Syndrome', 'Metabolic Syndrome-thought-Atherosclerosis', 'Spinal Cord Diseases-induced-Wounds and Injuries', 'Inflammation-underlie-Atherosclerosis', 'Sarcopenia-screen-Myalgia', 'Arthritis, Rheumatoid-screen-Myalgia', 'Stroke-diagnose-Atrial Fibrillation', 'Immunologic Deficiency Syndromes-result-Genetic Diseases, Inborn', 'Hypertension-increase-Alzheimer Disease', 'Hypertension-promote-Neurogenic Inflammation', 'Neurologic Manifestations-exacerbate-Hypertension', 'Leukoencephalopathies-include-Hypertension', 'Stroke, Lacunar-include-Hypertension', 'Cerebral Small Vessel Diseases-include-Leukoencephalopathies', 'Cerebral Small Vessel Diseases-include-Stroke, Lacunar', 'Infarction-remain-Myocardial Infarction', 'Inflammation-linked-Hypertension', 'Inflammation-linked-Diabetes Mellitus, Type 2', 'Dyslipidemias-accelerate-Ventricular Remodeling', 'Inflammation-associated-Acquired Immunodeficiency Syndrome', 'Acquired Immunodeficiency Syndrome-associated-Inflammation', 'Fibrosis-admitted-Respiratory Distress Syndrome', 'Fibrosis-admitted-Coronavirus Infections', 'Hypertension-admitted-Respiratory Distress Syndrome', 'Hypertension-admitted-Coronavirus Infections', 'Alzheimer Disease-resemble-Neurodegenerative Diseases', 'Alzheimer Disease-demonstrate-Neurodegenerative Diseases', 'Alzheimer Disease-decline-Neurodegenerative Diseases', 'Cardiac Output, Low-fall-Skin Diseases', 'Cardiac Output, Low-fall-Cardiovascular Diseases', 'Arthritis, Rheumatoid-aging-Hyperuricemia', 'Coronavirus Infections-cause-Death', 'Death-related-Nephritis, Interstitial', 'Heart Diseases-remain-Blood Coagulation Disorders', 'Heart Diseases-caused-Arbovirus Infections', 'Heart Diseases-remain-Mesenteric Vascular Occlusion', 'Blood Coagulation Disorders-remain-Mesenteric Vascular Occlusion', 'Blood Coagulation Disorders-remain-Heart Diseases', 'Mesenteric Vascular Occlusion-remain-Heart Diseases', 'Mesenteric Vascular Occlusion-remain-Infections', 'Anemia-control-Heart Failure', 'Heart Failure-drive-Tricuspid Valve Insufficiency', 'Tetany-remain-Spasm', 'Crohn Disease-use-Necrosis', 'Colitis, Ulcerative-use-Necrosis', 'Seizures-affect-Mitochondrial Diseases', 'Muscle Rigidity-demonstrate-REM Sleep Behavior Disorder', 'Muscular Atrophy-increase-Fractures, Bone', 'Aneurysm-influenced-Hypertension', 'Kidney Diseases-increasing-Anemia, Sickle Cell', 'Kidney Diseases-increasing-Death', 'Anemia, Sickle Cell-increasing-Death', 'Vertigo-considered-Vestibular Diseases', 'Hypertension-highlight-Diabetes Mellitus', 'Skin Neoplasms-indicate-Facial Dermatoses', 'Respiratory Insufficiency-include-Postoperative Complications', 'Pneumonia, Aspiration-include-Postoperative Complications', 'Respiratory Tract Infections-include-Postoperative Complications', 'Pleural Effusion-include-Postoperative Complications', 'Pneumothorax-include-Postoperative Complications', 'Bronchial Spasm-include-Postoperative Complications', 'Infections-determine-Thrombosis', 'Infections-determine-Death', 'Death-treat-Heart Failure', 'Heart Failure-worsened-Kidney Diseases', 'Dementia-estimated-Hypertension', 'Dementia-attributed-Hypertension', 'Alcoholism-show-Substance-Related Disorders', 'Alcoholism-show-Pulmonary Disease, Chronic Obstructive', 'Alcoholism-show-Blood Coagulation Disorders', 'Alcoholism-show-Peripheral Vascular Diseases', 'Brain Injuries-include-Inflammation', 'Brain Injuries-affect-Inflammation', 'Stillbirth-lumpe-Death', 'Stillbirth-predict-Death', 'Stroke-followed-Hemorrhage', 'Myocardial Infarction-followed-Hemorrhage', 'Hemorrhage-followed-Neoplasms', 'Pain-mediated-Arnold-Chiari Malformation', 'Retinal Detachment-droppe-Ocular Hypertension', 'Retinal Detachment-droppe-Hemorrhage', 'Retinal Detachment-droppe-Diabetes Mellitus', 'Myiasis-related-Neoplasms', 'Glioblastoma-influence-Neoplasms', 'Leukoaraiosis-correlate-Stroke', 'Death-decrease-Renal Insufficiency', 'Renal Insufficiency, Chronic-decrease-Renal Insufficiency', 'Infections-associated-Urinary Incontinence', 'Urinary Incontinence-associated-Infections', 'Microvascular Angina-associated-Carotid Stenosis', 'Carotid Stenosis-associated-Microvascular Angina', 'Infections-admitted-Respiration Disorders', 'Carcinoma, Squamous Cell-divide-Adenocarcinoma', 'Diabetes Mellitus-originate-Hyperglycemia', 'Cockayne Syndrome-characterized-Abnormalities, Drug-Induced', 'Cockayne Syndrome-characterized-Nervous System Diseases', 'Dementia, Vascular-found-Alzheimer Disease', 'Cardiovascular Diseases-include-Atrial Fibrillation', 'Heart Diseases-associated-Fibrosis', 'Fibrosis-associated-Heart Diseases', 'Alzheimer Disease-collected-Memory Disorders', 'Brain Diseases-related-Alzheimer Disease', 'TDP-43 Proteinopathies-associated-Alzheimer Disease', 'Alzheimer Disease-associated-TDP-43 Proteinopathies', 'TDP-43 Proteinopathies-resemble-Alzheimer Disease', 'TDP-43 Proteinopathies-induced-Alzheimer Disease', 'Rupture-reach-Death', 'Death-used-Cardiovascular Diseases', 'Pneumothorax-increase-Death', 'Obesity-associated-Memory Disorders', 'Memory Disorders-associated-Obesity', 'HIV Infections-become-Neoplasms', 'HIV Infections-become-Prostatic Neoplasms', 'Prostatic Neoplasms-become-Neoplasms', 'HIV Infections-work-Communicable Diseases', 'Neoplasms-receive-Communicable Diseases', 'Neoplasms-work-Communicable Diseases', 'Hearing Loss-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-Hearing Loss', 'Hearing Loss-associated-Hypertension', 'Hypertension-associated-Hearing Loss', 'Osteoarthritis-alleviate-Pain', 'Hypotension-exclude-Inflammatory Bowel Diseases', 'Colorectal Neoplasms-exclude-Inflammatory Bowel Diseases', 'Neoplasms-reduced-Leukoplakia', 'Graft vs Host Disease-contribute-Death', 'Infections-contribute-Death', 'Nerve Degeneration-develop-Alzheimer Disease', 'Nerve Degeneration-occur-Drug-Related Side Effects and Adverse Reactions', 'Cardiac Output, Low-fall-Sleep Wake Disorders', 'Cardiac Output, Low-associated-Dementia', 'Dementia-associated-Cardiac Output, Low', 'Death-control-Dementia', 'Obesity-target-Neoplasms', 'Papillomavirus Infections-target-Neoplasms', 'Neoplasms-present-Obesity', 'Peripheral Arterial Disease-include-Intermittent Claudication', 'Peripheral Arterial Disease-include-Ischemia', 'HIV Infections-related-Acquired Immunodeficiency Syndrome', 'HIV Infections-related-Drug-Related Side Effects and Adverse Reactions', 'Metabolic Syndrome-live-HIV Infections', 'Metabolic Diseases-followed-Hypertriglyceridemia', 'Hypertension-follow-Hypertriglyceridemia', 'Diabetes Mellitus-follow-Hypertriglyceridemia', 'Meningeal Neoplasms-suffer-Death', 'Death-differ-Meningeal Neoplasms', 'Cataract-shift-Astigmatism', 'Dysbiosis-facilitate-Dermatitis, Atopic', 'Constipation-suggested-Anorexia', 'Anorexia-diagnosed-Constipation', 'Constipation-associated-Anorexia', 'Anorexia-associated-Constipation', 'Heart Failure-affect-Diabetes Mellitus, Type 2', 'Muscular Dystrophy, Duchenne-suffer-Cardiomyopathy, Dilated', 'Muscular Dystrophy, Duchenne-lead-Heart Failure', 'Infections-acquire-West Nile Fever', 'Cardiomyopathy, Dilated-dilate-Heart Failure', 'Diabetic Nephropathies-increase-Stroke', 'Diabetic Nephropathies-increase-Cerebral Infarction', 'Diabetic Nephropathies-associated-Stroke', 'Stroke-associated-Diabetic Nephropathies', 'Diabetic Nephropathies-associated-Death', 'Death-associated-Diabetic Nephropathies', 'Stroke-increase-Diabetic Nephropathies', 'Urinary Tract Infections-followed-Infections', 'Inflammation-occur-Alzheimer Disease', 'Alzheimer Disease-caused-Dementia', 'Neoplasms-forecast-Lung Neoplasms', 'Leukemia, Lymphocytic, Chronic, B-Cell-associated-Seizures', 'Seizures-associated-Leukemia, Lymphocytic, Chronic, B-Cell', 'Leukemia, Lymphocytic, Chronic, B-Cell-complete-Seizures', 'Leukemia, Lymphocytic, Chronic, B-Cell-associated-Neoplasms', 'Neoplasms-associated-Leukemia, Lymphocytic, Chronic, B-Cell', 'Progeria-precipitate-Death', 'Genetic Diseases, Inborn-precipitate-Death', 'Communicable Diseases-become-HIV Infections', 'Death-increase-Cerebral Infarction', 'Cardiovascular Diseases-act-Coronary Artery Disease', 'Neurodegenerative Diseases-act-Coronary Artery Disease', 'Hyperthyroidism-associated-Brain Diseases', 'Brain Diseases-associated-Hyperthyroidism', 'Hyperthyroidism-associated-Memory Disorders', 'Memory Disorders-associated-Hyperthyroidism', 'Thyroid Hormone Resistance Syndrome-associated-Brain Diseases', 'Brain Diseases-associated-Thyroid Hormone Resistance Syndrome', 'Thyroid Hormone Resistance Syndrome-associated-Memory Disorders', 'Memory Disorders-associated-Thyroid Hormone Resistance Syndrome', 'Hypothyroidism-associated-Brain Diseases', 'Brain Diseases-associated-Hypothyroidism', 'Hypothyroidism-associated-Memory Disorders', 'Memory Disorders-associated-Hypothyroidism', 'Memory Disorders-include-Brain Diseases', 'Dementia-elevated-Vision Disorders', 'Vision Disorders-transition-Dementia', 'Infertility, Female-tied-Infections', 'Immunologic Deficiency Syndromes-cause-Infections', 'Alzheimer Disease-examine-Nervous System Diseases', 'Amyotrophic Lateral Sclerosis-fused-Sarcoma', 'Obesity-predicted-Ulcer', 'Diabetes Mellitus-predicted-Ulcer', 'Alzheimer Disease-show-Stroke', 'Alzheimer Disease-show-Epilepsy, Reflex', 'Colonic Neoplasms-known-Colonic Diseases', 'Diabetes Mellitus-type-Tremor', 'Alzheimer Disease-type-Tremor', 'Fibrosis-associated-Cardiac Complexes, Premature', 'Cardiac Complexes, Premature-associated-Fibrosis', 'Wilms Tumor-expressed-Hypotension', 'Hypotension-expressed-Leukemia, Myeloid, Acute', 'Heart Failure-assess-Femoral Neck Fractures', 'Heart Failure-lead-Femoral Neck Fractures', 'Femoral Neck Fractures-displace-Fragile X Syndrome', 'Femoral Neck Fractures-considered-Fragile X Syndrome', 'Fractures, Bone-displace-Fragile X Syndrome', 'Fractures, Bone-considered-Fragile X Syndrome', 'Obesity-contribute-Arthritis', 'Diabetes Mellitus-show-Hypertension', 'Diabetes Mellitus-show-Dyslipidemias', 'Anemia-associated-Ventricular Dysfunction', 'Ventricular Dysfunction-associated-Anemia', 'Renal Insufficiency, Chronic-associated-Ventricular Dysfunction', 'Ventricular Dysfunction-associated-Renal Insufficiency, Chronic', 'Heart Failure-misdiagnosed-Pulmonary Disease, Chronic Obstructive', 'Hypercholesterolemia-associated-Dementia', 'Dementia-associated-Hypercholesterolemia', 'Arthritis, Rheumatoid-identified-HIV Infections', 'HIV Infections-compare-Arthritis, Rheumatoid', 'Dementia-calculated-Death', 'Cardiovascular Diseases-protect-Inflammation', 'Coronary Artery Disease-present-Cardiovascular Diseases', 'Cardiovascular Diseases-present-Inflammation', 'Fever-diagnosed-Eosinophilia', 'Sleep Initiation and Maintenance Disorders-associated-Sleep Apnea Syndromes', 'Sleep Apnea Syndromes-associated-Sleep Initiation and Maintenance Disorders', 'Delirium-presented-Heart Failure', 'Delirium-presented-Cerebrovascular Disorders', 'Drug Eruptions-diagnosed-Eosinophilia', 'Delirium-presented-Constipation', 'Sleep Apnea Syndromes-study-Sleep Initiation and Maintenance Disorders', 'Lymphatic Diseases-diagnosed-Eosinophilia', 'Delirium-presented-Osteoporosis', 'Sleep Initiation and Maintenance Disorders-assess-Sleep Apnea Syndromes', 'Alzheimer Disease-exhibit-Cerebral Infarction', 'Inflammation-contribute-Delirium', 'Hyperhomocysteinemia-caused-Genetic Diseases, Inborn', 'Hyperhomocysteinemia-caused-Hypothyroidism', 'Hyperhomocysteinemia-caused-Kidney Diseases', 'Hyperhomocysteinemia-associated-Diabetes, Gestational', 'Diabetes, Gestational-associated-Hyperhomocysteinemia', 'Amyotrophic Lateral Sclerosis-include-TDP-43 Proteinopathies', 'Cardiomegaly-lead-Death', 'Hepatitis B, Chronic-divided-Liver Cirrhosis', 'Fibrosis-increase-Hepatitis B, Chronic', 'Fibrosis-progress-Hepatitis B, Chronic', 'Vision Disorders-associated-Communicable Diseases', 'Communicable Diseases-associated-Vision Disorders', 'Back Pain-associated-Osteoarthritis', 'Osteoarthritis-associated-Back Pain', 'Neck Pain-associated-Osteoarthritis', 'Osteoarthritis-associated-Neck Pain', 'Neck Pain-associated-Osteoporosis', 'Osteoporosis-associated-Neck Pain', 'Craniocerebral Trauma-result-Death', 'Wounds and Injuries-result-Death', 'Neurodegenerative Diseases-ascertained-Alzheimer Disease', 'Infections-associated-Hypertension', 'Hypertension-associated-Infections', 'Infections-associated-Respiratory Tract Diseases', 'Respiratory Tract Diseases-associated-Infections', 'Vision Disorders-develop-Camurati-Engelmann Syndrome', 'Osteoarthritis-pose-Pain', 'Osteoporosis-include-Diabetes Mellitus', 'Spinal Cord Injuries-range-Heart Failure', 'Diabetes Mellitus-attributed-Fractures, Bone', 'Neutropenia-involve-Respiration Disorders', 'Infections-involve-Respiration Disorders', 'Death-hospitalized-Infections', 'Death-demonstrate-Respiratory Distress Syndrome', 'Obesity-linked-Inflammation', 'Renal Insufficiency, Chronic-associated-Atrial Fibrillation', 'Atrial Fibrillation-associated-Renal Insufficiency, Chronic', 'Weight Loss-decrease-Urinary Incontinence', 'Deglutition Disorders-result-Hyperostosis, Diffuse Idiopathic Skeletal', 'Hyperostosis, Diffuse Idiopathic Skeletal-manifest-Deglutition Disorders', 'Hyperostosis, Diffuse Idiopathic Skeletal-manifest-Dysphonia', 'Hyperostosis, Diffuse Idiopathic Skeletal-manifest-Dyspnea', 'Hypotension-prevent-Diabetic Nephropathies', 'Hypotension-reach-Kidney Failure, Chronic', 'Diabetic Nephropathies-reach-Kidney Failure, Chronic', 'Cardiovascular Diseases-fear-Stroke', 'Cardiovascular Diseases-fear-Death', 'Femoral Fractures-compare-Death', 'Neoplasms-base-Cardiovascular Diseases', 'Infections-include-Hip Fractures', 'Cardiovascular Diseases-include-Hip Fractures', 'Death-include-Hip Fractures', 'Renal Insufficiency, Chronic-defined-Proteinuria', 'Hearing Loss-hear-Vision Disorders', 'Death-contribute-Thrombosis', 'Death-contribute-Multiple Organ Failure', 'Fractures, Bone-evaluate-Death', 'Wounds and Injuries-undergo-Hip Fractures', 'Death-receive-Neoplasms', 'Ventricular Fibrillation-predict-Death', 'Ventricular Fibrillation-predict-Myocardial Infarction', 'Albuminuria-associated-Heart Failure, Diastolic', 'Heart Failure, Diastolic-associated-Albuminuria', 'Obesity-escalate-Renal Insufficiency', 'Obesity-escalate-Kidney Diseases', 'Diabetes Mellitus-lagge-Kidney Diseases', 'Delirium-suffer-Death', 'Sleep Wake Disorders-base-Respiratory Insufficiency', 'Sleep Wake Disorders-assessed-Respiratory Insufficiency', 'Endometrial Neoplasms-characterised-Hyperplasia', 'Achondroplasia-characterized-Osteoporosis', 'Renal Insufficiency, Chronic-include-Kidney Diseases', 'Osteoporosis-lead-Femoral Neck Fractures', 'Osteoporosis-increase-Death', 'Arteriosclerosis-known-Sclerosis', 'Arteriosclerosis-known-Calcinosis', 'Sclerosis-known-Calcinosis', 'Multiple Myeloma-balance-Drug-Related Side Effects and Adverse Reactions', 'Death-include-Multiple Myeloma', 'Crohn Disease-exist-Colitis, Ulcerative', 'Crohn Disease-observed-Colitis, Ulcerative', 'Bone Diseases, Metabolic-protect-Osteoporosis', 'Seizures-increase-Death', 'Inflammation-cause-Mastocytosis, Systemic', 'Dyslipidemias-become-Cardiovascular Diseases', 'Dyslipidemias-become-Death', 'Alzheimer Disease-associated-Cerebral Amyloid Angiopathy', 'Cerebral Amyloid Angiopathy-associated-Alzheimer Disease', 'Thyroiditis, Autoimmune-prevent-Hypothyroidism', 'Hypertrophy-associated-Arrhythmias, Cardiac', 'Arrhythmias, Cardiac-associated-Hypertrophy', 'Delirium-produce-Psychomotor Agitation', 'Respiration Disorders-present-Delirium', 'Delirium-differentiate-Dementia', 'Fetal Alcohol Spectrum Disorders-exhibit-Microcephaly', 'Vascular Calcification-understand-Adrenal Insufficiency', 'Obesity-become-Osteoarthritis', 'Dysbiosis-help-Osteoarthritis', 'Hepatitis B-treated-Diabetes Mellitus', 'Hepatitis B-treated-Dyslipidemias', 'Hepatitis B-treated-Hypertension', 'Olfaction Disorders-result-Death', 'Ageusia-result-Death', 'Obesity-occur-Weight Loss', 'Ovarian Diseases-promote-Pulmonary Atresia', 'Inflammation-promote-Pulmonary Atresia', 'Fibrosis-promote-Pulmonary Atresia', 'Acute Coronary Syndrome-visit-Chest Pain', 'Inflammation-control-Hypertrophy', 'Metabolism, Inborn Errors-implicated-Metabolic Syndrome', 'Metabolism, Inborn Errors-implicated-Neoplasms', 'Hypertension, Pulmonary-induced-Hypoxia', 'Fasciculation-related-Fractures, Bone', 'Fasciculation-related-Death', 'Atrial Fibrillation-described-Adrenal Insufficiency', 'Osteomyelitis-cause-Paralysis', 'Delirium-develop-Deglutition Disorders', 'Osteomyelitis-cause-Sinus Thrombosis, Intracranial', 'Otitis-cause-Paralysis', 'Otitis-cause-Sinus Thrombosis, Intracranial', 'Sarcopenia-investigate-Kidney Diseases', 'Sarcopenia-develop-Kidney Failure, Chronic', 'Sarcopenia-increase-Kidney Failure, Chronic', 'Heart Diseases-develop-Sarcopenia', 'Sarcopenia-females-Heart Diseases', 'Sarcopenia-develop-Heart Diseases', 'Infections-include-Hypoxia, Brain', 'Neurologic Manifestations-arise-Stroke', 'Infections-complicate-Pulmonary Disease, Chronic Obstructive', 'Fractures, Bone-defined-Osteoporotic Fractures', 'Infections-lead-Inflammation', 'Aortic Valve Stenosis-contribute-Heart Failure', 'Aortic Valve Stenosis-contribute-Stroke', 'Blister-play-Inflammation', 'Cerebral Infarction-compare-Stroke', 'Cerebral Infarction-compare-Death', 'Dementia-compare-Stroke', 'Stroke-compare-Death', 'Stroke-compare-Dementia, Vascular', 'Prostatic Hyperplasia-exhibit-Osteoporosis', 'Diabetes Mellitus-focus-Obesity', 'Neoplasms-used-Melanoma', 'Melanoma-used-Neoplasms', 'Melanoma-change-Neoplasms', 'Alzheimer Disease-observed-Brain Diseases', 'Seizures-considered-Arbovirus Infections', 'Chronic Disease-corroborated-Mitochondrial Diseases', 'Obesity-corroborated-Mitochondrial Diseases', 'Wounds and Injuries-associated-Infections', 'Infections-associated-Wounds and Injuries', 'Pain-associated-Infections', 'Infections-associated-Pain', 'Esotropia-associated-Oculomotor Nerve Diseases', 'Oculomotor Nerve Diseases-associated-Esotropia', 'Hyperopia-accompanied-Myopia', 'Alzheimer Disease-experience-Seizures', 'Seizures-lead-Neurogenic Inflammation', 'Seizures-lead-Neurodegenerative Diseases', 'Epilepsy-lead-Neurogenic Inflammation', 'Epilepsy-lead-Neurodegenerative Diseases', 'Osteoarthritis-associated-Joint Diseases', 'Joint Diseases-associated-Osteoarthritis', 'Osteoarthritis-promote-Rheumatic Fever', 'Illusions-associated-Drug-Related Side Effects and Adverse Reactions', 'Drug-Related Side Effects and Adverse Reactions-associated-Illusions', 'Osteoarthritis-limit-Drug-Related Side Effects and Adverse Reactions', 'Osteoporosis-limit-Drug-Related Side Effects and Adverse Reactions', 'Rib Fractures-check-Chest Pain', 'Death-related-Glioblastoma', 'Fractures, Bone-represent-Chest Pain', 'Wounds and Injuries-affect-Death', 'Chest Pain-affect-Death', 'Brain Neoplasms-associated-Glioblastoma', 'Glioblastoma-associated-Brain Neoplasms', 'Neoplasms-enhance-Carcinoma', 'Neoplasms-play-Brain Injury, Chronic', 'Hypertension-lead-Neoplasms', 'Hypertension-lead-Arthritis', 'Hypertension-lead-Diabetes Mellitus', 'Hypertension-lead-Alzheimer Disease', 'Movement Disorders-evaluate-Parkinson Disease', 'Mitochondrial Diseases-linked-Neoplasms', 'Myalgia-attributed-Myotoxicity', 'Pigmentation Disorders-caused-Inflammation', 'Pigmentation Disorders-treat-Skin Diseases', 'Inflammation-treat-Skin Diseases', 'Eczema-provoke-Inflammation', 'Infections-provoke-Inflammation', 'Hyperalgesia-provoke-Inflammation', 'Stroke-involve-Hemiplegia', 'HIV Infections-affect-Infections', 'Obesity-represent-Communicable Diseases', 'Brain Injuries, Traumatic-known-Cerebrovascular Disorders', 'Malocclusion-used-Wounds and Injuries', 'Inflammation-studied-Metabolic Diseases', 'Cataract-result-Diabetes Mellitus', 'Blindness-result-Diabetes Mellitus', 'Cataract-alter-Lens Diseases', 'Fractures, Bone-constitute-Hip Fractures', 'Death-share-Cardiac Output, Low', 'Hyperlipidemias-associated-Cerebral Small Vessel Diseases', 'Cerebral Small Vessel Diseases-associated-Hyperlipidemias', 'Weight Loss-associated-Muscle Weakness', 'Muscle Weakness-associated-Weight Loss', 'Dermatitis-considered-Skin Diseases', 'Dermatitis-considered-Fecal Incontinence', 'Skin Diseases-considered-Fecal Incontinence', 'Obesity-related-Metabolic Syndrome', 'Pain-show-Fractures, Bone', 'Nerve Degeneration-lead-Death', 'Memory Disorders-observed-Brain Injuries, Traumatic', 'Cardiac Output, Low-drive-Inflammation', 'Neurodegenerative Diseases-related-Parkinson Disease', 'Hypothyroidism-play-Non-alcoholic Fatty Liver Disease', 'Metabolic Diseases-linked-Inflammation', 'HIV Infections-focus-Kidney Diseases', 'HIV Infections-focus-Neoplasms', 'HIV Infections-focus-Diabetes Mellitus', 'HIV Infections-focus-Cardiovascular Diseases', 'HIV Infections-focus-Stroke', 'HIV Infections-focus-Dyslipidemias', 'HIV Infections-focus-Osteoporosis', 'Inflammation-focus-Kidney Diseases', 'Inflammation-assess-Neoplasms', 'Inflammation-focus-Neoplasms', 'Inflammation-assess-Diabetes Mellitus', 'Inflammation-focus-Diabetes Mellitus', 'Inflammation-assess-Cardiovascular Diseases', 'Inflammation-focus-Cardiovascular Diseases', 'Inflammation-assess-Stroke', 'Inflammation-focus-Stroke', 'Inflammation-assess-Dyslipidemias', 'Inflammation-focus-Dyslipidemias', 'Inflammation-assess-Osteoporosis', 'Inflammation-focus-Osteoporosis', 'Hypertension-focus-Kidney Diseases', 'Hypertension-focus-Neoplasms', 'Hypertension-focus-Diabetes Mellitus', 'Hypertension-focus-Cardiovascular Diseases', 'Hypertension-focus-Stroke', 'Hypertension-focus-Dyslipidemias', 'Hypertension-focus-Osteoporosis', 'Kidney Diseases-focus-Neoplasms', 'Kidney Diseases-focus-Diabetes Mellitus', 'Kidney Diseases-focus-Stroke', 'Kidney Diseases-focus-Dyslipidemias', 'Kidney Diseases-focus-Osteoporosis', 'Neoplasms-focus-Diabetes Mellitus', 'Neoplasms-focus-Cardiovascular Diseases', 'Neoplasms-focus-Stroke', 'Neoplasms-focus-Dyslipidemias', 'Neoplasms-focus-Osteoporosis', 'Diabetes Mellitus-focus-Cardiovascular Diseases', 'Diabetes Mellitus-focus-Stroke', 'Diabetes Mellitus-focus-Dyslipidemias', 'Diabetes Mellitus-focus-Osteoporosis', 'Cardiovascular Diseases-focus-Stroke', 'Cardiovascular Diseases-focus-Dyslipidemias', 'Cardiovascular Diseases-focus-Osteoporosis', 'Stroke-focus-Dyslipidemias', 'Stroke-focus-Osteoporosis', 'Dyslipidemias-focus-Osteoporosis', 'Blood Coagulation Disorders-result-Intracranial Thrombosis', 'Coronary Artery Disease-manifest-Cerebral Small Vessel Diseases', 'Cerebral Small Vessel Diseases-appear-Leukoencephalopathies', 'Hypertension-tend-Death', 'Bronchitis-dominated-Erysipelas', 'Cytomegalovirus Infections-associated-Atherosclerosis', 'Atherosclerosis-associated-Cytomegalovirus Infections', 'Cytomegalovirus Infections-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-Cytomegalovirus Infections', 'Infections-increase-Ulcer', 'Infections-increase-Diabetic Foot', 'Infections-increase-Leg Ulcer', 'Cardiovascular Diseases-implicated-Cytomegalovirus Infections', 'Kidney Diseases-require-Pain', 'Plummer-Vinson Syndrome-present-Anemia, Iron-Deficiency', 'Plummer-Vinson Syndrome-present-Deglutition Disorders', 'Cerebral Small Vessel Diseases-associated-Thalamic Diseases', 'Thalamic Diseases-associated-Cerebral Small Vessel Diseases', 'Cerebral Small Vessel Diseases-associated-Hemorrhage', 'Hemorrhage-associated-Cerebral Small Vessel Diseases', 'Cerebral Small Vessel Diseases-associated-Putaminal Hemorrhage', 'Putaminal Hemorrhage-associated-Cerebral Small Vessel Diseases', 'Leukoaraiosis-used-Leukoencephalopathies', 'Leukoaraiosis-used-Diabetes Mellitus', 'Neoplasms-categorize-Glioma', 'Neoplasms-categorize-Glioblastoma', 'Glioma-categorize-Glioblastoma', 'Neoplasms-include-Glioma', 'Glioblastoma-progress-Glioma', 'Hemorrhage-associated-Thrombosis', 'Thrombosis-associated-Hemorrhage', 'Obesity-contribute-Metabolic Diseases', 'Neoplasm Metastasis-include-Colorectal Neoplasms', 'Proctitis-observed-Hemorrhage', 'Prostatic Neoplasms-masked-Hemorrhage', 'Proctitis-masked-Hemorrhage', 'Colorectal Neoplasms-masked-Hemorrhage', 'Chemical and Drug Induced Liver Injury-associated-Fibrosis', 'Fibrosis-associated-Chemical and Drug Induced Liver Injury', 'Adrenal Insufficiency-associated-Metabolic Syndrome', 'Metabolic Syndrome-associated-Adrenal Insufficiency', 'Diabetes Mellitus, Type 2-defined-Metabolic Syndrome', 'Diabetes Mellitus, Type 2-suggest-Diabetes Mellitus', 'Cardiovascular Diseases-define-Primary Dysautonomias', 'Primary Dysautonomias-defined-Hypotension, Orthostatic', 'Diabetes Mellitus-develop-Primary Dysautonomias', 'Diabetes Mellitus-develop-Death', 'Primary Dysautonomias-develop-Death', 'Hypotension, Orthostatic-result-Hypovolemia', 'Myotonic Dystrophy-present-Hypotension, Orthostatic', 'Chronic Disease-associated-Fatigue', 'Fatigue-associated-Chronic Disease', 'Fatigue Syndrome, Chronic-represent-Primary Dysautonomias', 'Fatigue Syndrome, Chronic-represent-Fatigue', 'Fatigue Syndrome, Chronic-lead-Occupational Diseases', 'Primary Dysautonomias-represent-Fatigue', 'Primary Dysautonomias-lead-Occupational Diseases', 'Fatigue-lead-Occupational Diseases', 'Obesity-include-Multiple Chronic Conditions', 'Diabetes Mellitus-include-Multiple Chronic Conditions', 'Cardiovascular Diseases-include-Multiple Chronic Conditions', 'Dementia-remain-Death', 'Chronic Disease-suffer-Pain', 'Sarcopenia-accelerated-Heart Failure', 'Sarcopenia-termed-Pulmonary Disease, Chronic Obstructive', 'Chronic Disease-followed-Intellectual Disability', 'Nerve Degeneration-precede-Hearing Loss', 'Nerve Degeneration-produce-Hearing Loss', 'Carcinoma, Merkel Cell-contribute-Dysbiosis', 'Immunologic Deficiency Syndromes-encourage-Carcinogenesis', 'Dementia-revealed-Parkinson Disease', 'Diabetes Mellitus-include-Parkinson Disease', 'Hypertension-include-Parkinson Disease', 'Alzheimer Disease-follow-Inflammation', 'Alzheimer Disease-restricted-Neurodegenerative Diseases', 'Alzheimer Disease-possess-Neurodegenerative Diseases', 'Amyloidosis-play-Alzheimer Disease', 'Inflammation-restricted-Neurodegenerative Diseases', 'Inflammation-possess-Neurodegenerative Diseases', 'Hypertension-used-Pulmonary Disease, Chronic Obstructive', 'Heart Diseases-used-Pulmonary Disease, Chronic Obstructive', 'Neoplasms-used-Pulmonary Disease, Chronic Obstructive', 'Hypogonadism-associated-Virilism', 'Virilism-associated-Hypogonadism', 'Leukemia, Myeloid-treated-Neoplasms', 'Leukemia, Myeloid-include-Autoimmune Diseases', 'Leukemia, Myeloid-treated-Autoimmune Diseases', 'Ossification of Posterior Longitudinal Ligament-estimate-Myoclonic Epilepsies, Progressive', 'Death-follow-Aneurysm', 'Neurogenic Inflammation-include-Alzheimer Disease', 'Diabetes Mellitus-estimated-Heart Failure', 'Diabetes Mellitus-result-Heart Failure', 'Diabetes Mellitus-result-Cardiac Complexes, Premature', 'Heart Failure-result-Cardiac Complexes, Premature', 'Neoplasms-limit-Inflammation', 'Neoplasms-limit-Chemical and Drug Induced Liver Injury', 'Inflammation-limit-Chemical and Drug Induced Liver Injury', 'Inflammation-limit-Infections', 'Psychoses, Substance-Induced-define-Hallucinations', 'Idiopathic Pulmonary Fibrosis-cause-Lung Diseases', 'Idiopathic Pulmonary Fibrosis-contribute-Pulmonary Fibrosis', 'Idiopathic Pulmonary Fibrosis-translate-Emphysema', 'Idiopathic Pulmonary Fibrosis-induced-Emphysema', 'Lung Diseases-increase-Pulmonary Fibrosis', 'Idiopathic Pulmonary Fibrosis-translate-Hypertension, Pulmonary', 'Idiopathic Pulmonary Fibrosis-induced-Hypertension, Pulmonary', 'Idiopathic Pulmonary Fibrosis-translate-Lung Neoplasms', 'Idiopathic Pulmonary Fibrosis-induced-Lung Neoplasms', 'Idiopathic Pulmonary Fibrosis-translate-Coronary Artery Disease', 'Idiopathic Pulmonary Fibrosis-induced-Coronary Artery Disease', 'Idiopathic Pulmonary Fibrosis-translate-Diabetes Mellitus', 'Idiopathic Pulmonary Fibrosis-induced-Diabetes Mellitus', 'Idiopathic Pulmonary Fibrosis-translate-Chronic Disease', 'Pyoderma Gangrenosum-associated-Inflammatory Bowel Diseases', 'Inflammatory Bowel Diseases-associated-Pyoderma Gangrenosum', 'Diverticulitis-included-Pyoderma Gangrenosum', 'Neoplasms-develop-Neurologic Manifestations', 'Postpartum Hemorrhage-affect-Fractures, Bone', 'Alzheimer Disease-associated-Glucose Metabolism Disorders', 'Glucose Metabolism Disorders-associated-Alzheimer Disease', 'Weight Loss-predict-Alzheimer Disease', 'Alzheimer Disease-increase-Obesity', 'Alzheimer Disease-progress-Weight Loss', 'Alzheimer Disease-correlate-Death', 'Weight Loss-correlate-Death', 'Fatty Liver-include-Chemical and Drug Induced Liver Injury', 'Carcinoma, Hepatocellular-include-Chemical and Drug Induced Liver Injury', 'Metabolic Diseases-include-Chemical and Drug Induced Liver Injury', 'Hypoxia-represent-Nervous System Diseases', 'Diabetes Mellitus-study-Death', 'Brain Infarction-include-Cerebrovascular Disorders', 'Coronavirus Infections-lead-Arbovirus Infections', 'Delirium-associated-Alcoholic Intoxication', 'Alcoholic Intoxication-associated-Delirium', 'Sarcopenia-include-Obesity', 'Sarcopenia-range-Obesity', 'Autoimmune Diseases-make-Infections', "Sjogren's Syndrome-make-Infections", 'Delirium-predict-Sepsis', 'Sarcopenia-evaluate-Inflammation', 'Neurodegenerative Diseases-diagnose-Chronic Traumatic Encephalopathy', 'Chronic Traumatic Encephalopathy-differentiate-Nervous System Diseases', 'Chronic Traumatic Encephalopathy-present-Dementia', 'Dermatitis Herpetiformis-resemble-Conjunctivitis, Bacterial', 'Dermatitis Herpetiformis-include-Dermatitis, Exfoliative', 'Conjunctivitis, Bacterial-include-Dermatitis, Exfoliative', 'Death-reduce-Peripheral Arterial Disease', 'Inflammation-range-Arthritis', 'Anophthalmos-include-Pain Insensitivity, Congenital', 'Endocrine System Diseases-include-Pain Insensitivity, Congenital', 'Wounds and Injuries-include-Pain Insensitivity, Congenital', 'Metabolic Syndrome-defined-Metabolic Diseases', 'Joint Diseases-associated-Chronic Disease', 'Chronic Disease-associated-Joint Diseases', 'Osteoporosis-coexist-Metabolic Diseases', 'Osteoporosis-coexist-Obesity', 'Osteoporosis-coexist-Diabetes Mellitus', 'Osteoporosis-coexist-Fatty Liver', 'Osteoporosis-coexist-Cardiovascular Diseases', 'Metabolic Diseases-avoided-Osteoporosis', 'Communicable Diseases-study-Adrenal Insufficiency', 'Adrenal Insufficiency-study-Spinal Cord Injuries', 'Death-attributed-Drug Overdose', 'Death-attributed-Acquired Immunodeficiency Syndrome', 'Diabetes Mellitus-use-Death', 'Death-initiate-Diabetes Mellitus', 'Diabetes Mellitus-refer-Death', 'Death-discuss-Diabetes Mellitus', 'Sarcopenia-attenuated-Fractures, Bone', 'Heart Failure-assess-Pulmonary Disease, Chronic Obstructive', 'Neoplasms-live-Spinal Cord Injuries', 'Spinal Cord Injuries-treated-Breast Neoplasms', 'Renal Insufficiency-detected-Chemical and Drug Induced Liver Injury', 'Malocclusion-included-Cataract', 'Deglutition Disorders-detected-Esophageal Neoplasms', 'Bacterial Infections-play-Fatigue Syndrome, Chronic', 'Fatigue Syndrome, Chronic-defined-Fatigue', 'Infections-lead-Peptic Ulcer', 'Inflammation-lead-Peptic Ulcer', 'Infections-prevent-Fatigue Syndrome, Chronic', 'Infections-progress-Fatigue Syndrome, Chronic', 'Cardiac Output, Low-result-Wounds and Injuries', 'Fatigue Syndrome, Chronic-develop-Peptic Ulcer', 'Hypoxia-aggravate-Peritoneal Neoplasms', 'Diabetes Mellitus-use-Neural Tube Defects', 'Sarcopenia-related-Bone Diseases, Metabolic', 'Heart Failure-involve-Multiple Myeloma', 'Multiple Myeloma-cause-Kidney Diseases', 'Multiple Myeloma-cause-Anemia', 'Cardiovascular Diseases-known-Death', 'Cardiovascular Diseases-known-Inflammation', 'Death-known-Inflammation', 'Myocardial Infarction-belong-Cardiovascular Diseases', 'Myocardial Infarction-belong-Death', 'Stroke-belong-Cardiovascular Diseases', 'Cardiovascular Diseases-belong-Death', 'Seizures-understudied-Parkinson Disease', 'Seizures-impacted-Parkinson Disease', 'Parkinson Disease-mediate-Seizures', 'Seizures-mediate-Parkinson Disease', 'Urticaria-experience-Communicable Diseases', 'Angioedema-experience-Communicable Diseases', 'Neurodegenerative Diseases-integrate-Neurotoxicity Syndromes', 'Drug-Related Side Effects and Adverse Reactions-recapitulate-Neurodegenerative Diseases', 'Keratosis, Actinic-indicate-Carcinoma, Squamous Cell', 'Skin Diseases-indicate-Carcinoma, Squamous Cell', 'Keratosis, Actinic-transform-Carcinoma, Squamous Cell', 'Fever-follow-Pharyngeal Diseases', 'Infections-contribute-Inflammation', 'Death-use-Fractures, Bone', 'Hip Fractures-stratify-Fractures, Bone', 'Death-stratify-Fractures, Bone', 'Inflammation-thought-Death', 'Inflammation-include-Infections', 'Hepatitis C-share-Inflammation', 'Cardiac Output, Low-fall-Heart Diseases', 'Mitochondrial Diseases-regulate-Obesity', 'Mitochondrial Diseases-become-Nervous System Diseases', 'Thrombosis-progress-Myocardial Infarction', 'Thrombosis-impair-Stroke', 'Thrombosis-impair-Death', 'Muscular Atrophy-decrease-Heart Failure', 'Osteoarthritis, Knee-damage-Cartilage Diseases', 'Dyspareunia-associated-Pelvic Pain', 'Pelvic Pain-associated-Dyspareunia', 'Pelvic Pain-associated-Myofascial Pain Syndromes', 'Myofascial Pain Syndromes-associated-Pelvic Pain', 'Dyspareunia-associated-Myofascial Pain Syndromes', 'Myofascial Pain Syndromes-associated-Dyspareunia', 'Inflammation-treat-Infections', 'Sleep Initiation and Maintenance Disorders-control-Infections', 'Infections-prevent-Inflammation', 'Brain Injuries, Traumatic-screened-Sleep Initiation and Maintenance Disorders', 'Heart Block-associated-Cross Infection', 'Cross Infection-associated-Heart Block', 'Drug-Related Side Effects and Adverse Reactions-associated-Cross Infection', 'Cross Infection-associated-Drug-Related Side Effects and Adverse Reactions', 'Communicable Diseases-remain-Death', 'Death-related-Inflammation', 'Death-related-Chronic Disease', 'Diabetes Mellitus-correlated-Stroke', 'Diabetes Mellitus-correlated-Renal Insufficiency, Chronic', 'Diabetes Mellitus-correlated-Cardiovascular Diseases', 'Stroke-correlated-Cardiovascular Diseases', 'Renal Insufficiency, Chronic-correlated-Cardiovascular Diseases', 'Bone Malalignment-contribute-Osteoarthritis', 'Osteoarthritis-involved-Inflammation', 'Osteoarthritis-focus-Pain', 'Metabolic Syndrome-follow-Diabetes Mellitus', 'Metabolic Syndrome-found-Chagas Disease', 'Coronavirus Infections-exhibit-Death', 'Hearing Loss-co-occur-Tinnitus', 'Hearing Loss-hear-Vision, Low', 'Hearing Loss-hear-Memory Disorders', 'Hearing Loss-compared-Sensation Disorders', 'Vision, Low-compared-Sensation Disorders', 'Memory Disorders-compared-Sensation Disorders', 'Communicable Diseases-use-Legionellosis', 'Communicable Diseases-use-Death', 'Thyroid Diseases-resemble-Hypothyroidism', 'Epilepsy, Temporal Lobe-analyzed-Lewy Body Disease', 'Lung Neoplasms-reveal-Death', 'Neoplasms-reveal-Death', 'Neoplasms-identify-Breast Neoplasms, Male', 'Inflammation-differ-HIV Infections', 'Cerebral Infarction-produced-Arterial Occlusive Diseases', 'Brain Ischemia-associated-Neurodegenerative Diseases', 'Neurodegenerative Diseases-associated-Brain Ischemia', 'Arterial Occlusive Diseases-produced-Dementia, Vascular', 'Atrophy-known-Respiratory Insufficiency', 'Muscle Weakness-known-Respiratory Insufficiency', 'Respiratory Insufficiency-caused-Cachexia', 'Respiratory Insufficiency-define-Sarcopenia', 'Chronic Disease-establish-Pain', 'Fractures, Open-followed-Urinary Bladder Calculi', 'Prostatic Hyperplasia-diagnose-Urinary Bladder Calculi', 'Multiple Chronic Conditions-result-Hypoxia', 'Brain Diseases-include-HIV Infections', 'HIV Infections-contribute-Infections', 'HIV Infections-contribute-Dementia', 'Infections-contribute-Dementia', 'Death-lead-Obesity', 'Death-lead-Coronary Artery Disease', 'Death-lead-Hypertension', 'Hip Fractures-use-Wounds and Injuries', 'Hyperglycemia-manage-Diabetes Mellitus', 'Hyperglycemia-manage-Heart Failure', 'Diabetes Mellitus-increase-Heart Failure', 'Heart Failure-influence-Diabetes Mellitus', 'Diabetes Mellitus-induce-Heart Failure', 'Pneumonia-complicated-Respiratory Insufficiency', 'Sensation Disorders-spoke-Fatigue', 'Sensation Disorders-spoke-Pain', 'Sensation Disorders-spoke-Cough', 'Weight Loss-associated-Pain, Postoperative', 'Pain, Postoperative-associated-Weight Loss', 'Weight Loss-associated-Gastroesophageal Reflux', 'Gastroesophageal Reflux-associated-Weight Loss', 'Weight Loss-develop-Gastroesophageal Reflux', 'Pain, Postoperative-develop-Gastroesophageal Reflux', 'Diabetes Mellitus, Type 2-linked-Cardiovascular Diseases', 'Sarcopenia-address-Vision Disorders', 'Diabetes Mellitus, Type 2-linked-Neoplasms', 'Diabetes Mellitus, Type 2-linked-Neurodegenerative Diseases', 'Diabetes Mellitus-associated-Breast Neoplasms', 'Breast Neoplasms-associated-Diabetes Mellitus', 'Hallucinations-associated-Alzheimer Disease', 'Alzheimer Disease-associated-Hallucinations', 'Inflammation-demonstrate-Pain', 'Low Back Pain-demonstrate-Pain', 'Blindness-characterised-Death', 'Musculoskeletal Pain-prevent-Gait Disorders, Neurologic', 'Chronic Disease-characterized-Vision Disorders', 'Chronic Disease-trigger-Vision Disorders', 'Cerebral Small Vessel Diseases-contribute-Stroke', 'Cerebral Small Vessel Diseases-contribute-Cerebral Infarction', 'Cerebral Small Vessel Diseases-include-Arteriosclerosis', 'Cerebral Small Vessel Diseases-include-Cerebral Amyloid Angiopathy', 'Cerebral Small Vessel Diseases-include-Genetic Diseases, Inborn', 'Cerebral Small Vessel Diseases-include-Inflammation', 'Atrial Fibrillation-share-Obesity', 'Atrial Fibrillation-share-Diabetes Mellitus', 'Tuberculosis, Pulmonary-facilitate-Tuberculosis', 'Sleep Initiation and Maintenance Disorders-perform-Frailty', 'Frailty-appear-Obesity', 'Pain-perform-Dementia', 'Infections-defined-Respiratory Tract Diseases', 'Pain-associated-Stomach Diseases', 'Stomach Diseases-associated-Pain', 'Myocardial Infarction-reflected-Death', 'Death-occur-Hypoglycemia', 'Death-related-Lymphoma', 'Osteoarthritis-demonstrate-Pain', 'Alveolar Bone Loss-caused-Periodontitis', 'Periodontitis-caused-Bone Neoplasms', 'Alzheimer Disease-cause-Nerve Degeneration', 'Osteoporosis-considered-Obesity', 'Liver Failure-promote-Muscular Atrophy', 'Obesity-reverse-Muscular Atrophy', 'Diabetes Mellitus-reverse-Muscular Atrophy', 'Proteinuria-end-Kidney Failure, Chronic', 'Proteinuria-control-Hypertension', 'Proteinuria-end-Renal Insufficiency, Chronic', 'Stroke-follow-Lung Diseases', 'Stroke-follow-Heart Diseases', 'Pneumonia-perform-Death', 'Pneumonia-perform-Signs and Symptoms, Digestive', 'Dysbiosis-affect-Atrial Fibrillation', 'Dysbiosis-contribute-Atrial Fibrillation', 'Parkinsonian Disorders-distinguish-Parkinson Disease, Secondary', 'Parkinson Disease-distinguish-Neurodegenerative Diseases', 'Parkinson Disease-distinguish-Shy-Drager Syndrome', 'Parkinson Disease-distinguish-Supranuclear Palsy, Progressive', 'Coronary Aneurysm-cause-Chest Pain', 'Stroke-caused-Atherosclerosis', 'Stroke-caused-Plaque, Atherosclerotic', 'Heredodegenerative Disorders, Nervous System-culminate-Blindness', 'Neoplasms-lead-Bone Marrow Diseases', 'Cardiovascular Diseases-exclude-Dementia', 'Stroke-exclude-Dementia', 'Diabetes Mellitus-exclude-Dementia', 'Asthma-exclude-Dementia', 'Pulmonary Disease, Chronic Obstructive-exclude-Dementia', 'Hip Fractures-exclude-Dementia', 'Neoplasms-exclude-Dementia', 'Brain Injuries, Traumatic-fall-Cardiac Output, Low', 'Hematoma, Epidural, Spinal-decrease-Heart Failure', 'Fractures, Bone-decrease-Heart Failure', 'Hemorrhage-decrease-Heart Failure', 'Pulmonary Disease, Chronic Obstructive-increase-Inflammation', 'Pulmonary Disease, Chronic Obstructive-intensify-Muscle Weakness', 'Inflammation-intensify-Muscle Weakness', 'Bone Diseases, Metabolic-associated-Death', 'Death-associated-Bone Diseases, Metabolic', 'Atherosclerosis-represent-Calcinosis', 'Fibrosis-manage-Myelodysplastic Syndromes', 'Dry Eye Syndromes-manifest-Inflammation', 'Dry Eye Syndromes-caused-Drug Hypersensitivity', 'Inflammation-caused-Drug Hypersensitivity', 'Death-accompanied-Hypertension', 'Death-accompanied-Respiratory Tract Diseases', 'Death-accompanied-Dementia', 'Hypertension-reduced-Death', 'Respiratory Tract Diseases-reduced-Death', 'Dementia-reduced-Death', 'Heart Diseases-include-Communicable Diseases', 'Communicable Diseases-associated-Stroke', 'Stroke-associated-Communicable Diseases', 'Communicable Diseases-associated-Heart Diseases', 'Heart Diseases-associated-Communicable Diseases', 'Infections-associated-Gonorrhea', 'Gonorrhea-associated-Infections', 'Infections-associated-Chemical and Drug Induced Liver Injury', 'Chemical and Drug Induced Liver Injury-associated-Infections', 'Infections-associated-Trichomonas Infections', 'Trichomonas Infections-associated-Infections', 'Infections-associated-Candidiasis, Cutaneous', 'Candidiasis, Cutaneous-associated-Infections', 'Infections-associated-Obstetric Labor, Premature', 'Obstetric Labor, Premature-associated-Infections', 'Infections-associated-Infertility, Female', 'Infertility, Female-associated-Infections', 'Alzheimer Disease-cause-Dementia', 'Neurodegenerative Diseases-cause-Dementia', 'Atrophy-correspond-Alzheimer Disease', 'Atrophy-highlighted-Alzheimer Disease', 'Diabetes Mellitus-lack-Communicable Diseases', 'Infections-depend-Critical Illness', 'Chronic Disease-impact-Heart Failure', 'Sarcopenia-impact-Heart Failure', 'Muscular Diseases-associated-Death', 'Death-associated-Muscular Diseases', 'Leukemia-include-Hematologic Diseases', 'Anemia-include-Hematologic Diseases', 'Asthma-documented-Hypertension', 'Diabetes Mellitus-documented-Hypertension', 'Renal Insufficiency, Chronic-documented-Hypertension', 'Alzheimer Disease-observed-Neurologic Manifestations', 'Diabetes Mellitus-recommend-Hypoglycemia', 'Language Development Disorders-underlie-Pulmonary Disease, Chronic Obstructive', 'Insulin Resistance-increase-Hypoglycemia', 'Craniocerebral Trauma-classified-Meningitis', 'Hemoptysis-associated-Death', 'Death-associated-Hemoptysis', 'Chest Pain-associated-Death', 'Death-associated-Chest Pain', 'Dysgeusia-associated-Death', 'Death-associated-Dysgeusia', 'Inflammation-demonstrate-Death', 'Metabolic Diseases-demonstrate-Death', 'Delirium-demonstrate-Death', 'Infections-highlight-Alzheimer Disease', 'Infections-highlight-Dementia, Vascular', 'Infections-highlight-Dementia', 'Sepsis-caused-Inflammation', 'Sepsis-caused-Hereditary Breast and Ovarian Cancer Syndrome', 'Inflammation-reflect-Sepsis', 'Inflammation-observed-Sepsis', 'Hereditary Breast and Ovarian Cancer Syndrome-observed-Sepsis', 'Fibrosis-decrease-Carcinoma, Hepatocellular', 'Weight Loss-observed-Dementia', 'Dementia-show-Retinal Degeneration', 'Renal Insufficiency, Chronic-cause-Atherosclerosis', 'Renal Insufficiency, Chronic-cause-Vascular Calcification', 'Renal Insufficiency, Chronic-cause-Fibrosis', 'Renal Insufficiency, Chronic-cause-Calcinosis', 'Aortic Diseases-define-Aortic Aneurysm', 'Aortic Diseases-affected-Intracranial Aneurysm', 'Hypertension-affected-Intracranial Aneurysm', 'Diabetes Mellitus-affected-Intracranial Aneurysm', 'Intracranial Aneurysm-considered-Aortic Diseases', 'Hemolysis-increase-Glucosephosphate Dehydrogenase Deficiency', 'Hemolysis-enhance-Glucosephosphate Dehydrogenase Deficiency', 'Thrombosis-enhance-Glucosephosphate Dehydrogenase Deficiency', 'Thrombosis-increase-Glucosephosphate Dehydrogenase Deficiency', 'Infections-diagnosed-Glucosephosphate Dehydrogenase Deficiency', 'Diabetes Mellitus-induce-Cardiomegaly', 'Cardiomegaly-induce-Glucose Metabolism Disorders', 'Diabetes Mellitus-increased-Glucose Intolerance', 'Dwarfism, Pituitary-increased-Glucose Intolerance', 'Voice Disorders-present-Cerebral Palsy', 'Voice Disorders-present-Constipation', 'Cerebral Palsy-present-Constipation', 'Gingival Hemorrhage-account-Inflammation', 'Constipation-impact-Cerebral Palsy', 'Obesity-associated-Metabolic Diseases', 'Metabolic Diseases-associated-Obesity', 'Infertility, Female-caused-Genetic Diseases, Inborn', 'Cardiovascular Diseases-comprise-Death', 'Cardiovascular Diseases-comprise-Myocardial Infarction', 'Cardiovascular Diseases-comprise-Heart Failure', 'Ischemia-protected-Ovarian Diseases', 'Endocarditis-associated-Stroke', 'Stroke-associated-Endocarditis', 'Endocarditis-associated-Acute Kidney Injury', 'Acute Kidney Injury-associated-Endocarditis', 'Rheumatic Fever-underlie-Kidney Diseases', 'Rheumatic Fever-emerge-HIV Infections', 'Kidney Diseases-emerge-HIV Infections', 'Endocarditis-emerge-HIV Infections', 'Atrophy-related-Deglutition Disorders', 'Death-reduce-Heart Failure', 'Immunologic Deficiency Syndromes-diagnose-Hypogonadism', 'Atrophy-characterized-Vascular Calcification', 'Atrophy-characterized-Cardiomegaly', 'Atrophy-characterized-Sarcopenia', 'Arteriosclerosis-characterized-Vascular Calcification', 'Arteriosclerosis-characterized-Cardiomegaly', 'Arteriosclerosis-characterized-Sarcopenia', 'Arteriosclerosis-associated-Inflammation', 'Inflammation-associated-Arteriosclerosis', 'Vascular Calcification-associated-Inflammation', 'Inflammation-associated-Vascular Calcification', 'Cardiomegaly-associated-Inflammation', 'Inflammation-associated-Cardiomegaly', 'Renal Insufficiency, Chronic-show-Venous Thrombosis', 'Coma-examine-Death', 'Immunologic Deficiency Syndromes-defined-Adrenal Insufficiency', 'Tongue Diseases-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-Tongue Diseases', 'Tongue Diseases-associated-Dyslipidemias', 'Dyslipidemias-associated-Tongue Diseases', 'Learning Disabilities-prevent-Neurodegenerative Diseases', 'Hepatitis B-lead-Carcinoma, Hepatocellular', 'Pulmonary Fibrosis-develop-Lung Injury', 'Alzheimer Disease-influence-Death', 'Alzheimer Disease-influence-Dementia', 'Death-caused-Endocarditis', 'Liver Cirrhosis, Alcoholic-use-Meningitis, Bacterial', 'Fibrosis-become-Infections', 'Retinal Degeneration-impact-Tooth, Impacted', 'Aneurysm-result-Death', 'Aneurysm-include-Abnormalities, Drug-Induced', 'Infections-affected-Central Nervous System Diseases', 'Hemophilia A-develop-Cardiovascular Diseases', 'Prostatic Hyperplasia-represent-Metabolic Syndrome', 'Infections-detected-Rickettsia Infections', 'Infections-cause-Bronchiolitis', 'Obesity-promote-Prostatic Neoplasms', 'Diabetic Foot-cause-Infections', 'Diabetic Foot-increase-Death', 'Hypothyroidism-found-Hyperthyroidism', 'Hypothyroidism-found-Thyrotoxicosis', 'Drug-Related Side Effects and Adverse Reactions-cause-Hyperthyroidism', 'Polyarteritis Nodosa-present-Abdominal Pain', 'Death-experience-Dementia', 'Hematologic Diseases-occur-Malaria', 'Nervous System Diseases-result-Stroke', 'Acute Lung Injury-associated-Death', 'Death-associated-Acute Lung Injury', 'Necrosis-reduce-Peripheral Nervous System Diseases', 'Spinal Cord Injuries-hold-Uterine Cervicitis', 'Obesity-related-Inflammation', 'Alcoholism-infect-Infections', 'Acute Kidney Injury-reduce-Death', 'Blood Loss, Surgical-improve-Fractures, Bone', 'Nocturia-associated-Heart Failure', 'Heart Failure-associated-Nocturia', 'Cardiovascular Diseases-show-Heart Failure', 'Hypertension-forced-Nocturia', 'Hypertension-cause-Nocturia', 'Heart Failure-cause-Nocturia', 'Atrial Fibrillation-exacerbate-Aneurysm', 'Cardiovascular Diseases-cause-Nocturia', 'Atrial Fibrillation-exacerbate-Cardiovascular Diseases', 'Atrial Fibrillation-alter-Cardiac Output, High', 'Infections-correlate-Necrosis', 'Sarcopenia-discuss-Neoplasms', 'Malnutrition-discuss-Neoplasms', 'Cachexia-discuss-Neoplasms', 'Fever-include-Gastrointestinal Diseases', 'Fatigue-include-Gastrointestinal Diseases', 'Cough-include-Gastrointestinal Diseases', 'Diabetes Mellitus, Type 1-experience-Diabetes Mellitus', 'Neurodegenerative Diseases-surround-Alzheimer Disease', 'Primary Ovarian Insufficiency-increase-Osteoporosis', 'Arbovirus Infections-lead-Death', 'Vaginitis-caused-Wounds and Injuries', 'Multiple Chronic Conditions-involved-Diabetes Mellitus', 'Thyroid Diseases-involved-Diabetes Mellitus', 'Obesity-involved-Diabetes Mellitus', 'Spasm-reduce-Pain', 'Fractures, Bone-improve-Diabetes Mellitus, Type 2', 'Carcinoma, Squamous Cell-treated-Neoplasms', 'Vision Disorders-develop-Dementia', 'Motion Sickness-included-Vestibular Diseases', 'Primary Ovarian Insufficiency-increase-Cardiovascular Diseases', 'Primary Ovarian Insufficiency-defined-Renal Insufficiency', 'Primary Ovarian Insufficiency-include-Chromosome Aberrations', 'Ovarian Diseases-associated-Primary Ovarian Insufficiency', 'Primary Ovarian Insufficiency-associated-Ovarian Diseases', 'Heart Failure-include-Kyphosis', 'Venous Thrombosis-result-Death', 'Bradycardia-worsen-Dehydration', 'Ischemia-worsen-Dehydration', 'Migraine Disorders-precede-Headache', 'Migraine Disorders-precede-Epilepsy', 'Migraine Disorders-cause-Cerebral Infarction', 'Seizures-associated-Pain', 'Pain-associated-Seizures', 'Seizures-associated-Fatigue', 'Fatigue-associated-Seizures', 'Seizures-associated-Colorectal Neoplasms', 'Colorectal Neoplasms-associated-Seizures', 'Inflammation-induced-Infections', 'Heart Failure-undergo-Atrial Fibrillation', 'Cerebral Infarction-related-Heart Failure', 'Heart Failure-suffer-Brain Injury, Chronic', 'Neoplasms-occur-Dermatomyositis', 'Neoplasms-diagnosed-Dermatomyositis', 'Neoplasms-follow-Dermatomyositis', 'Neoplasms-diagnosed-Polymyositis', 'Myositis-diagnosed-Dermatomyositis', 'Neoplasms-follow-Breast Neoplasms', 'Myositis-diagnosed-Polymyositis', 'Dermatomyositis-follow-Breast Neoplasms', 'Dermatomyositis-include-Neoplasms', 'Polymyositis-include-Neoplasms', 'Death-implement-Chronic Disease', 'Myositis-attributed-Neoplasms', 'Inflammation-attributed-Neoplasms', 'Tooth Loss-control-Dementia', 'Subarachnoid Hemorrhage-characterized-Hydrocephalus', 'Parkinson Disease, Secondary-utilize-Parkinson Disease', 'Hypertension-associated-Aortic Diseases', 'Aortic Diseases-associated-Hypertension', 'Atherosclerosis-associated-Aortic Diseases', 'Aortic Diseases-associated-Atherosclerosis', 'Malnutrition-experience-Obesity', 'Malnutrition-experience-Diabetes Mellitus', 'Malnutrition-experience-Hypertension', 'Hypertension-develop-Hypothalamic Neoplasms', 'Hypertension-lead-Hypothalamic Diseases', 'Immunologic Deficiency Syndromes-lead-Hypertension', 'Neurotoxicity Syndromes-trigger-Alzheimer Disease', 'Hyperplasia-coexist-Endometrial Neoplasms', 'Endometrial Neoplasms-found-Hyperplasia', 'Aortic Diseases-confusing-Inflammation', 'Learning Disabilities-compare-HIV Infections', 'Psychomotor Disorders-compare-HIV Infections', 'Heart Failure-associated-Acute Kidney Injury', 'Acute Kidney Injury-associated-Heart Failure', 'Nervous System Diseases-assist-Alzheimer Disease', 'Cerebral Infarction-assess-Death', 'Atrial Fibrillation-assess-Death', 'Fractures, Bone-confirm-Death', 'Infections-develop-Chemical and Drug Induced Liver Injury', 'Infections-experience-Liver Diseases', 'Death-understand-Coronary Artery Disease', 'Seizures-forfeit-Death', 'Cardiovascular Diseases-improve-Fatigue', 'Sarcopenia-detect-Fractures, Bone', 'Sleep Wake Disorders-defined-Hypotension', 'Sleep Wake Disorders-impair-Coronary Artery Disease', 'Gliosis-observed-Sclerosis', 'Atrophy-observed-Sclerosis', 'Parkinson Disease-include-Glucose Metabolism Disorders', 'Drug-Related Side Effects and Adverse Reactions-protect-Alzheimer Disease', 'Alzheimer Disease-involve-Muscular Disorders, Atrophic', 'Parkinson Disease-involve-Nerve Degeneration', 'Neurodegenerative Diseases-involve-Nerve Degeneration', 'Skin Diseases-associated-Inflammation', 'Inflammation-associated-Skin Diseases', 'Hemoglobinopathies-enhance-Infections', 'Goiter-correlated-Hemorrhage', 'Respiratory Distress Syndrome-include-Death', 'Atrophy-experience-Alzheimer Disease', 'Periodontal Diseases-tend-Periodontitis', 'Periodontitis-related-Infections', 'Periodontitis-related-Inflammation', 'Infections-associated-Fractures, Open', 'Fractures, Open-associated-Infections', 'Neurodegenerative Diseases-targeted-Nervous System Diseases', 'Neurodegenerative Diseases-targeted-Heart Failure', 'Nervous System Diseases-linked-Alzheimer Disease', 'Nervous System Diseases-enhance-Inflammation', 'Nervous System Diseases-found-Alzheimer Disease', 'Nervous System Diseases-found-Parkinson Disease', 'Sleep Initiation and Maintenance Disorders-diagnosed-Dementia', 'Diabetic Cardiomyopathies-cause-Heart Failure', 'Diabetic Cardiomyopathies-increase-Death', 'Diabetic Cardiomyopathies-increase-Diabetes Mellitus', 'Diabetic Cardiomyopathies-involve-Fibrosis', 'Heart Diseases-inhibit-Fibrosis', 'Inflammation-contribute-Alzheimer Disease', 'Alzheimer Disease-suggest-Monoclonal Gammopathy of Undetermined Significance', 'Gout-associated-Dementia', 'Dementia-associated-Gout', 'Gout-assess-Dementia', 'Gout-decrease-Dementia', 'Dementia-involve-Alzheimer Disease', 'Obesity-contain-Neoplasms', 'Infections-minimized-Kidney Failure, Chronic', 'Infections-mitigate-Kidney Failure, Chronic', 'Kidney Failure, Chronic-maintain-Thrombosis', 'Neoplasms-involved-Breast Neoplasms', 'Obesity-linked-Neoplasms', 'Pain-associated-Hyperopia', 'Hyperopia-associated-Pain', 'Refractive Errors-predispose-Pain', 'Refractive Errors-predispose-Hyperopia', 'Pain-predispose-Hyperopia', 'Death-note-Lymphopenia', 'Death-note-Arrhythmias, Cardiac', 'Alzheimer Disease-exhibit-Nervous System Diseases', 'Alzheimer Disease-exhibit-Lewy Body Disease', 'Dementia-exhibit-Nervous System Diseases', 'Dementia-exhibit-Lewy Body Disease', 'Lewy Body Disease-include-Nervous System Diseases', 'Nervous System Diseases-mitigate-Alzheimer Disease', 'Hypertension-associated-Periodontitis', 'Periodontitis-associated-Hypertension', 'Cockayne Syndrome-exhibit-Microcephaly', 'Cockayne Syndrome-exhibit-Intellectual Disability', 'Liver Failure-produce-Death', 'Inflammation-burdened-Coinfection', 'Learning Disabilities-distinguish-Alzheimer Disease', 'Hypertension-develop-Dementia', 'Nephrolithiasis-associated-Renal Insufficiency, Chronic', 'Renal Insufficiency, Chronic-associated-Nephrolithiasis', 'Infections-manifest-Bacteremia', 'Infections-manifest-Meningoencephalitis', 'Bacteremia-manifest-Fetal Diseases', 'Hypertension-facilitate-Dementia', 'Meningoencephalitis-manifest-Fetal Diseases', 'Hypertension-characterize-Alzheimer Disease', 'Cerebral Amyloid Angiopathy-detected-Hypertension', 'Alzheimer Disease-detected-Hypertension', 'Hypertension-outline-Dementia', 'Leukoencephalopathies-outline-Dementia', 'Hypertension-cause-Brain Damage, Chronic', 'Hypertension-cause-Alzheimer Disease', 'Inflammation-contribute-Autoimmune Diseases', 'Inflammation-contribute-Metabolic Diseases', 'Pain-reduce-Neoplasms', 'Huntington Disease-uncovered-Genetic Diseases, Inborn', 'Nerve Degeneration-implicated-Neurodegenerative Diseases', 'Peripheral Vascular Diseases-diagnosed-Cold Injury', 'Peripheral Vascular Diseases-cause-Cold Injury', 'Death-vary-Neoplasms', 'Diabetes Mellitus-account-Obesity', 'Heart Failure-include-Chronic Disease', 'Obesity-associated-Neurodegenerative Diseases', 'Neurodegenerative Diseases-associated-Obesity', 'Diabetes Mellitus, Type 2-associated-Neurodegenerative Diseases', 'Neurodegenerative Diseases-associated-Diabetes Mellitus, Type 2', 'Infections-prevent-Dementia', 'Liver Cirrhosis-characterized-Liver Diseases', 'Liver Cirrhosis-characterized-Fibrosis', 'Liver Cirrhosis-characterized-Hypertension', 'Liver Diseases-lead-Fibrosis', 'Liver Diseases-lead-Hypertension', 'Liver Cirrhosis-associated-Sarcopenia', 'Sarcopenia-associated-Liver Cirrhosis', 'Sarcopenia-influence-Death', 'Liver Cirrhosis-influence-Death', 'Mitochondrial Diseases-feed-Back Pain', 'Pain Insensitivity, Congenital-diagnosed-Osteoarthritis', 'Pain-provide-Pain Insensitivity, Congenital', 'Vascular System Injuries-highlight-Inflammation', 'Neck Pain-sustain-Fractures, Bone', 'Hypotension-induced-Hypertension', 'Hypotension-induced-Hereditary Breast and Ovarian Cancer Syndrome', 'Hypotension-induced-Obesity', 'Drug-Related Side Effects and Adverse Reactions-include-Anemia', 'Myocardial Infarction-account-Death', 'Drug-Related Side Effects and Adverse Reactions-include-Thrombocytopenia', 'Pneumonia-encountered-Death', 'Drug-Related Side Effects and Adverse Reactions-include-Neutropenia', 'Drug-Related Side Effects and Adverse Reactions-include-Nausea', 'Drug-Related Side Effects and Adverse Reactions-include-Pneumonia', 'Osteoporosis-classified-Osteoporotic Fractures', 'Fractures, Bone-classified-Osteoporotic Fractures', 'Atrial Fibrillation-evidenced-Thromboembolism', 'Atrial Fibrillation-evidenced-Death', 'Death-include-Sarcopenia', 'Sclerosis-develop-Encephalomyelitis, Autoimmune, Experimental', 'Neurodegenerative Diseases-play-Alzheimer Disease', 'Inflammation-study-Alzheimer Disease', 'Pain-identified-Back Pain', 'Pain-identified-Neck Pain', 'Diabetes Mellitus-associated-Liver Diseases', 'Liver Diseases-associated-Diabetes Mellitus', 'Death-increase-Liver Diseases', 'Death-accentuated-Liver Diseases', 'Arrhythmias, Cardiac-explain-Death', 'Arrhythmias, Cardiac-explain-Cardiovascular Diseases', 'Atherosclerosis-characterized-Cerebral Infarction', 'Hyperglycemia-include-Atherosclerosis', 'Hyperlipidemias-include-Atherosclerosis', 'Cerebral Infarction-related-Carotid Stenosis', 'Idiopathic Pulmonary Fibrosis-base-Pulmonary Fibrosis', 'Idiopathic Pulmonary Fibrosis-drive-Pulmonary Fibrosis', 'Muscle Weakness-recognized-Heart Failure', 'Skin Diseases, Vesiculobullous-implicated-Parkinson Disease', 'Dementia-account-Death', 'Inflammation-exert-Malnutrition', 'Atherosclerosis-act-Calcinosis', 'Diabetes Mellitus-presented-Tuberculosis', 'Alzheimer Disease-described-Neurodegenerative Diseases', 'Cerebral Hemorrhage-present-Hypertension', 'Cerebral Hemorrhage-present-Hypercholesterolemia', 'Cerebral Hemorrhage-present-Cardiovascular Diseases', 'Cerebral Hemorrhage-identified-Hypercholesterolemia', 'Cerebral Hemorrhage-identified-Cardiovascular Diseases', 'Death-related-Endometrial Neoplasms', 'Hypotension, Orthostatic-associated-Kidney Diseases', 'Kidney Diseases-associated-Hypotension, Orthostatic', 'Periodontal Diseases-caused-Endotoxemia', 'Mastocytosis, Systemic-caused-Endotoxemia', 'Endotoxemia-affect-Obesity', 'Heart Failure-induced-Neoplasms', 'Heart Diseases-induced-Neoplasms', 'Diabetes Mellitus-linked-Hip Fractures', 'Osteoporosis-linked-Hip Fractures', 'Diabetes Mellitus-include-Hypertension', 'Coronary Artery Disease-result-Headache Disorders, Secondary', 'HIV Infections-face-Chronic Disease', 'HIV Infections-face-Diabetes Mellitus', 'HIV Infections-characterized-Inflammation', 'Chronic Disease-report-Pain', 'Neurodegenerative Diseases-disentangle-Alzheimer Disease', 'Cardiovascular Diseases-used-Dementia', 'Metabolic Syndrome-related-Cardiovascular Diseases', 'Cataract-progress-Rupture', 'Cataract-begin-Eye Infections', 'Cataract-begin-Inflammation', 'Rupture-begin-Eye Infections', 'Rupture-begin-Inflammation', 'Metabolic Syndrome-decline-Myocardial Infarction', 'Metabolic Syndrome-decline-Cerebral Infarction', 'Metabolic Syndrome-decline-Heart Failure', 'Metabolic Syndrome-determined-Diabetes Mellitus', 'Venous Thromboembolism-include-Thrombosis', 'Stroke-include-Thrombosis', 'Myocardial Infarction-include-Thrombosis', 'Ischemia-include-Thrombosis', 'Pneumonia-progress-Viremia', 'Respiratory Insufficiency-progress-Viremia', 'Headache-described-Sleep Apnea, Obstructive', 'Papilledema-suggest-Hypertension', 'Papilledema-suggest-Cerebral Hemorrhage', 'Papilledema-observed-Heredodegenerative Disorders, Nervous System', 'Hypertension-measured-Heredodegenerative Disorders, Nervous System', 'Cerebral Hemorrhage-observed-Heredodegenerative Disorders, Nervous System', 'Sarcopenia-reported-Obesity', 'Hypercapnia-associated-Sleep Apnea, Obstructive', 'Sleep Apnea, Obstructive-associated-Hypercapnia', 'Back Pain-associated-Neoplasms', 'Neoplasms-associated-Back Pain', 'Hypotension-reduce-Diabetes Mellitus, Type 2', 'Diarrhea-cause-Infections', 'Cough-cause-Infections', 'Joint Dislocations-recorded-Infections', 'Diabetes Mellitus-involve-Polycystic Ovary Syndrome', 'Fever-occur-Cough', 'Fever-occur-Dyspnea', 'Hypokalemia-associated-Disease Progression', 'Disease Progression-associated-Hypokalemia', 'Alzheimer Disease-recognize-Foreign Bodies', 'Tinnitus-lead-Vision Disorders', 'Infections-lead-Vision Disorders', 'Sarcopenia-suggest-Fractures, Bone', 'Seizures-assessed-Gait Disorders, Neurologic', 'Seizures-include-Stiff-Person Syndrome', 'Dysbiosis-linked-Inflammation', 'Dementia-account-Neurodegenerative Diseases', 'Infections-modulate-Inflammation', 'Death-confer-Diabetes Mellitus', 'Glomerulonephritis-lead-Renal Insufficiency', 'Dementia-persist-Diabetes Mellitus', 'Death, Sudden-reduce-Cardiomyopathy, Hypertrophic', 'Craniocerebral Trauma-identify-Intracranial Hemorrhages', 'Cardiomyopathy, Hypertrophic-terminate-Ventricular Fibrillation', 'Ventricular Fibrillation-emerge-Death', 'Stroke-follow-Hip Fractures', 'Myocardial Infarction-underestimated-Death', 'Dementia-included-Sarcopenia', 'Dementia-included-Hypotension, Orthostatic', 'Dementia-included-Cardiac Output, Low', 'Dementia-included-Sleep Initiation and Maintenance Disorders', 'Dementia-included-Sleep Wake Disorders', 'Dementia-included-Ulcer', 'Infections-protect-Lung Injury', 'Xerostomia-associated-Rheumatic Diseases', 'Rheumatic Diseases-associated-Xerostomia', 'Xerostomia-associated-Diabetes Mellitus, Type 2', 'Diabetes Mellitus, Type 2-associated-Xerostomia', 'Xerostomia-diagnosed-Diabetes Mellitus, Type 2', 'Alzheimer Disease-ranked-Death', 'Alzheimer Disease-ranked-Heart Diseases', 'Alzheimer Disease-ranked-Neoplasms', 'Death-ranked-Heart Diseases', 'Death-ranked-Neoplasms', 'Sarcopenia-suffer-Chronic Disease', 'Sarcopenia-diagnosed-Inflammatory Bowel Diseases', 'Osteoporosis-diagnosed-Inflammatory Bowel Diseases', 'Alzheimer Disease-attenuate-Memory Disorders', 'Sarcopenia-include-Osteoporosis', 'Dyspnea-provide-Pulmonary Disease, Chronic Obstructive', 'Pulmonary Disease, Chronic Obstructive-rate-Dyspnea', 'Cystic Fibrosis-recognized-Lung Diseases', 'Medulloblastoma-classified-Neoplasms', 'Lymphoma, B-Cell-show-Lymphoma, T-Cell', 'Postoperative Hemorrhage-undergo-Intracranial Aneurysm', 'Postoperative Hemorrhage-defined-Hematoma', 'Kidney Diseases-indicate-Aneurysm', 'Aneurysm-addressed-Metabolic Syndrome', 'Skin Diseases-use-Erythema', 'Sarcopenia-associated-Hip Fractures', 'Hip Fractures-associated-Sarcopenia', 'HIV Infections-suffer-Sleep Wake Disorders', 'Sleep Wake Disorders-suffer-HIV Infections', 'Inflammation-understood-Headache Disorders, Secondary', 'Alzheimer Disease-understood-Headache Disorders, Secondary', 'Fatty Liver-gain-Carcinoma, Pancreatic Ductal', 'Diabetes Mellitus-remain-Fatty Liver', 'Osteoporosis-accompany-Fractures, Bone', 'Chemical and Drug Induced Liver Injury-consist-Liver Cirrhosis', 'Chemical and Drug Induced Liver Injury-consist-Infections', 'Chemical and Drug Induced Liver Injury-change-Hepatitis B', 'Dementia, Vascular-followed-Dementia', 'Non-alcoholic Fatty Liver Disease-assessed-Immunologic Deficiency Syndromes', 'Immunologic Deficiency Syndromes-assessed-Metabolic Syndrome', 'Heart Diseases-suffer-Hematologic Diseases', 'Heart Diseases-suffer-Dyslipidemias', 'Heart Diseases-suffer-Hypothyroidism', 'Heart Diseases-undergo-Kidney Failure, Chronic', 'Seizures-reduce-Sarcopenia', 'Heart Diseases-undergo-Adrenal Insufficiency', 'Hypothyroidism-undergo-Kidney Failure, Chronic', 'Hypothyroidism-undergo-Adrenal Insufficiency', 'Cerebral Amyloid Angiopathy-present-Cerebral Hemorrhage', 'Infarction-yield-Cerebral Small Vessel Diseases', 'Stomach Neoplasms-identify-Malnutrition', 'Stroke-caused-Infarction, Posterior Cerebral Artery', 'Fatigue-accepted-Deglutition Disorders', 'Stroke-caused-Brain Injuries', 'Alzheimer Disease-act-Dementia', 'Alzheimer Disease-act-Lewy Body Disease', 'Cerebral Small Vessel Diseases-associated-Alzheimer Disease', 'Alzheimer Disease-associated-Cerebral Small Vessel Diseases', 'Arteriolosclerosis-associated-Dementia', 'Dementia-associated-Arteriolosclerosis', 'Death-observed-Neoplasms', 'Death-observed-Colorectal Neoplasms', 'Death-observed-Urinary Bladder Neoplasms', 'Obesity-worsen-Back Pain', 'Obesity-worsen-Muscle Weakness', 'Obesity-incur-Cardiac Output, Low', 'Back Pain-incur-Cardiac Output, Low', 'Muscle Weakness-incur-Cardiac Output, Low', 'Discitis-show-Infections', 'Discitis-cause-Infections', 'Aneurysm-associated-Memory Disorders', 'Memory Disorders-associated-Aneurysm', 'Immunologic Deficiency Syndromes-live-Diabetes Mellitus', 'Diabetes Mellitus-live-Hypogonadism', 'Hypertension, Pulmonary-recal-Memory Disorders', 'Death-occur-Disease Progression', 'Femoral Neck Fractures-described-Muscular Dystrophy, Duchenne', 'Osteoporosis-associated-Hypertriglyceridemia', 'Hypertriglyceridemia-associated-Osteoporosis', 'Sleepiness-used-Sleep Wake Disorders', 'Sleepiness-measure-Sleep Wake Disorders', 'Alzheimer Disease-mediate-Neurodegenerative Diseases', 'Melanoma-associated-Neoplasm Invasiveness', 'Neoplasm Invasiveness-associated-Melanoma', 'Aortic Valve Stenosis-represent-Cardiovascular Diseases', 'Aortic Valve Stenosis-represent-Death', 'Inflammation-contribute-Vascular Remodeling', 'Fibrosis-reduce-Coronary Artery Disease', 'Viremia-prevent-Immunologic Deficiency Syndromes', 'Respiratory Distress Syndrome-lead-Death', 'Pericardial Effusion-occur-Thrombocytopenia', 'Pericardial Effusion-occur-Anemia, Sideroblastic', 'Sarcopenia-defined-Musculoskeletal Pain', 'Atrial Fibrillation-outperform-Heart Failure', 'Atrial Fibrillation-outperform-Hypertension', 'Atrial Fibrillation-outperform-Diabetes Mellitus', 'Atrial Fibrillation-outperform-Stroke', 'Chemical and Drug Induced Liver Injury-include-Wounds and Injuries', 'Chemical and Drug Induced Liver Injury-include-Hepatitis, Viral, Human', 'Colorectal Neoplasms-contribute-Death', 'Neoplasms-arise-Liver Diseases', 'Heart Arrest-prevent-Neoplasms', 'Neoplasms-contribute-Death', 'Death-decline-Diabetes Mellitus', 'Diabetes Mellitus-decline-Death', 'Diabetes Mellitus-decline-Cardiovascular Diseases', 'Nerve Degeneration-accompany-Cerebrovascular Disorders', 'Demyelinating Diseases-accompany-Cerebrovascular Disorders', 'Inflammation-accompany-Cerebrovascular Disorders', 'Hemorrhage-classified-Cerebral Infarction', 'Hemorrhage-classified-Hematoma', 'Diabetes Mellitus-encountered-Stroke', 'Diabetes Mellitus-encountered-Hemorrhage', 'Diabetes Mellitus-develop-Hemorrhage', 'Hypertension-encountered-Stroke', 'Hypertension-encountered-Hemorrhage', 'Hypertension-develop-Hemorrhage', 'Hyperlipidemias-encountered-Stroke', 'Hyperlipidemias-encountered-Hemorrhage', 'Hyperlipidemias-develop-Hemorrhage', 'Muscular Dystrophy, Duchenne-result-Sleep Initiation and Maintenance Disorders', 'Urinary Incontinence-become-Hydrocephalus', 'Alzheimer Disease-characterize-Memory Disorders', 'Atrial Fibrillation-link-Cerebrovascular Disorders', 'Musculoskeletal Diseases-predict-Sleep Initiation and Maintenance Disorders', 'Pain-predict-Sleep Initiation and Maintenance Disorders', 'Pain-measured-Sleep Initiation and Maintenance Disorders', 'Pain-prioritize-Sleep Initiation and Maintenance Disorders', 'Aortic Valve Stenosis-obtained-Calcinosis', 'Cerebrovascular Disorders-reveal-Dementia', 'Osteoarthritis-cure-Cartilage Diseases', 'Cartilage Diseases-related-Osteoarthritis', 'Delirium-considered-Disease', 'Leukemia, Myeloid-associated-Eosinophilia', 'Eosinophilia-associated-Leukemia, Myeloid', 'Delirium-identified-Wounds and Injuries', 'Mitochondrial Diseases-contribute-Skin Diseases', 'Prediabetic State-mediate-Cardiovascular Diseases', 'Diabetes Mellitus-mediate-Cardiovascular Diseases', 'Cardiovascular Diseases-mediate-Prediabetic State', 'Prediabetic State-control-Diabetes Mellitus', 'Diabetes Mellitus-lead-Prediabetic State', 'Infections-see-Coronavirus Infections', 'Kidney Diseases-confirm-Polyneuropathies', 'Retinal Diseases-confirm-Polyneuropathies', 'Polyneuropathies-confirm-Coronary Artery Disease', 'Infections-cause-Respiration Disorders', 'Respiration Disorders-cause-Death', 'Diabetes Mellitus-associated-Chronic Kidney Disease-Mineral and Bone Disorder', 'Chronic Kidney Disease-Mineral and Bone Disorder-associated-Diabetes Mellitus', 'Hypertension-associated-Chronic Kidney Disease-Mineral and Bone Disorder', 'Chronic Kidney Disease-Mineral and Bone Disorder-associated-Hypertension', 'Liver Cirrhosis-associated-Chronic Kidney Disease-Mineral and Bone Disorder', 'Chronic Kidney Disease-Mineral and Bone Disorder-associated-Liver Cirrhosis', 'HIV Infections-cause-Dysbiosis', 'Endometrial Neoplasms-constitute-Neoplasms', 'Femoral Neck Fractures-involve-Osteoporosis', 'Seizures-reduce-Sleep Wake Disorders', 'Urinary Bladder Neoplasms-downloaded-Neoplasms', 'Urogenital Neoplasms-play-Neoplasms', 'Prostatic Neoplasms-downloaded-Neoplasms', 'Xeroderma Pigmentosum-exhibit-Neoplasms', 'Neoplasms-occur-Xeroderma Pigmentosum', 'Primary Ovarian Insufficiency-overrepresented-Xeroderma Pigmentosum', 'Lung Neoplasms-occur-Xeroderma Pigmentosum', 'Central Nervous System Neoplasms-occur-Xeroderma Pigmentosum', 'Leukemia-occur-Xeroderma Pigmentosum', 'Lymphoma-occur-Xeroderma Pigmentosum', 'Aneurysm-diagnose-Peripheral Arterial Disease', 'Aneurysm-diagnose-Stroke', 'Aneurysm-become-Diabetes Mellitus, Type 2', 'Inappropriate ADH Syndrome-include-Hyponatremia', 'Neurologic Manifestations-link-Memory Disorders', 'Neurologic Manifestations-link-Neurodegenerative Diseases', 'Hypertension-associated-Calcinosis', 'Calcinosis-associated-Hypertension', 'Vasospasm, Intracranial-associated-Death', 'Death-associated-Vasospasm, Intracranial', 'Myocardial Infarction-include-Diabetes Mellitus', 'Diabetes Mellitus-result-Kidney Diseases', 'Dementia-bring-Death', 'Critical Illness-trigger-Myosarcoma', 'Kidney Failure, Chronic-undergo-Arteriovenous Fistula', 'Immunologic Deficiency Syndromes-result-Cardiovascular Diseases', 'Dementia-remain-Muscular Disorders, Atrophic', 'Cerebral Amyloid Angiopathy-result-Brain Diseases', 'HIV Infections-associated-Obesity, Abdominal', 'Obesity, Abdominal-associated-HIV Infections', 'HIV Infections-attenuate-Obesity, Abdominal', 'Hypertension-attenuate-Obesity, Abdominal', 'Fever-progress-Respiratory Distress Syndrome', 'Cough-progress-Respiratory Distress Syndrome', 'Fatigue-progress-Respiratory Distress Syndrome', 'Hyperinsulinism-related-Chemical and Drug Induced Liver Injury', 'Postpartum Hemorrhage-reveal-Venous Thrombosis', 'Gait Disorders, Neurologic-decline-Stroke', 'Mitochondrial Diseases-involved-Alzheimer Disease', 'Nerve Degeneration-aggregate-Sotos Syndrome', 'Fractures, Bone-occur-Osteoporosis', 'Genetic Diseases, Inborn-lead-Death, Sudden, Cardiac', 'Heart Diseases-lead-Death, Sudden, Cardiac', 'Death, Sudden, Cardiac-lead-Coronary Artery Disease', 'Diabetes Mellitus-base-Death', 'Heart Failure-decrease-Diabetes Mellitus', 'Stroke-decrease-Diabetes Mellitus', 'Hypertension-characterize-Diabetes Mellitus', 'Diabetes Mellitus-characterize-Infections', 'Atrial Fibrillation-manifest-Cardiovascular Diseases', 'Periodontitis-affect-Osteoporosis', 'Atrial Fibrillation-fulfil-Hepatolenticular Degeneration', 'Acute Kidney Injury-decrease-Renal Insufficiency', 'Osteoarthritis-characterized-Kidney Failure, Chronic', 'Brain Injuries, Traumatic-introduce-Brain Injuries', 'Death-associated-Meningeal Neoplasms', 'Meningeal Neoplasms-associated-Death', 'Amyotrophic Lateral Sclerosis-represent-Neurodegenerative Diseases', 'Dementia-affect-Neurodegenerative Diseases', 'Seizures-associated-Hypertension', 'Hypertension-associated-Seizures', 'Hyponatremia-associated-Sarcopenia', 'Sarcopenia-associated-Hyponatremia', 'Acute Kidney Injury-identified-Kidney Diseases', 'Death-use-Communicable Diseases', 'Infections-protected-Chronic Disease', 'Craniofacial Abnormalities-relate-Wounds and Injuries', 'Respiratory Distress Syndrome-remain-Death', 'Respiratory Insufficiency-remain-Death', 'Osteoporosis-required-Fractures, Bone', 'Pigmentation Disorders-observed-Carcinoma, Basal Cell', 'Renal Insufficiency, Chronic-contribute-Death', 'Hemolytic-Uremic Syndrome-implicated-Vascular Calcification', 'Vascular Calcification-induced-Hemolytic-Uremic Syndrome', 'HIV Infections-select-Musculoskeletal Diseases', 'Fractures, Bone-associated-Alzheimer Disease', 'Alzheimer Disease-associated-Fractures, Bone', 'Osteoporosis-undergo-Fractures, Bone', 'Dementia-undergo-Fractures, Bone', 'Hypertension-combine-Death', 'Postpartum Hemorrhage-indicate-Intraoperative Complications', 'Aspergillosis, Allergic Bronchopulmonary-recognized-Lung Diseases, Obstructive', 'Aspergillosis, Allergic Bronchopulmonary-recognized-Pulmonary Disease, Chronic Obstructive', 'Aspergillosis, Allergic Bronchopulmonary-recognized-Fibrosis', 'Pulmonary Disease, Chronic Obstructive-include-Lung Diseases, Obstructive', 'Fibrosis-include-Lung Diseases, Obstructive', 'Fibrosis-associated-Aspergillosis', 'Aspergillosis-associated-Fibrosis', 'Asthma-require-Lung Diseases, Obstructive', 'Fanconi Anemia-characterised-Bone Marrow Failure Disorders', 'Fanconi Anemia-characterised-Pancytopenia', 'Cystic Fibrosis-require-Lung Diseases, Obstructive', 'Fanconi Anemia-evolve-Neoplasms', 'Lung Diseases, Obstructive-require-Aspergillosis, Allergic Bronchopulmonary', 'Genetic Diseases, Inborn-characterised-Bone Marrow Failure Disorders', 'Genetic Diseases, Inborn-characterised-Pancytopenia', 'Genetic Diseases, Inborn-evolve-Neoplasms', 'Bone Marrow Failure Disorders-evolve-Neoplasms', 'Pancytopenia-evolve-Neoplasms', 'Progeria-cause-Cardiovascular Diseases', 'Infections-tend-Death', 'Infections-tend-Multiple Organ Failure', 'Death-lead-Multiple Organ Failure', 'Atrial Fibrillation-admitted-Acute Coronary Syndrome', 'Respiratory Insufficiency-lead-Thrombosis', 'Hypoglycemia-related-Diabetes Mellitus', 'Death-experience-Heart Failure', 'Headache Disorders, Secondary-manifest-Psychomotor Agitation', 'Dysbiosis-involved-Adrenal Insufficiency', 'Dysbiosis-manifest-Adrenal Insufficiency', 'Sarcopenia-define-Fasciculation', 'Sarcopenia-define-Fractures, Bone', 'Sarcopenia-define-Death', 'Obesity-connected-Sarcopenia', 'Metabolic Diseases-make-Death', 'Metabolic Diseases-share-Inflammation', 'Acute Kidney Injury-underlie-Renal Insufficiency, Chronic', 'Hyperoxia-explain-Lung Diseases', 'Hyperoxia-increase-Arbovirus Infections', 'Hearing Loss-develop-Dementia', 'Hearing Loss-prevent-Dementia', 'Bone Marrow Failure Disorders-include-Fanconi Anemia', 'Fanconi Anemia-include-Neoplasms', 'Fanconi Anemia-develop-Neoplasms', 'Bone Marrow Failure Disorders-develop-Neoplasms', 'Inflammation-result-Neoplasms', 'Infertility, Female-observed-Fanconi Anemia', 'Cerebral Infarction-characterized-Inflammation', 'Stroke-suffer-Infections', 'Death-associated-Atherosclerosis', 'Atherosclerosis-associated-Death', 'Stroke-exhibit-Pneumonia', 'Death-characterized-Inflammation', 'Atherosclerosis-characterized-Inflammation', 'Inflammation-aggravate-Motor Neuron Disease', 'Diabetes Mellitus-characterized-Inflammation', 'Stroke-associated-Inflammation', 'Inflammation-associated-Stroke', 'Stroke-characterized-Inflammation', 'Leukemia, Myelomonocytic, Chronic-present-Diabetes Insipidus, Neurogenic', 'Neurotoxicity Syndromes-lead-Diffuse Neurofibrillary Tangles with Calcification', 'Infections-reported-Death', 'Olfaction Disorders-occur-Alzheimer Disease', 'Renal Insufficiency, Chronic-drive-Acute Kidney Injury', 'Diabetes Mellitus-drive-Acute Kidney Injury', 'HIV Infections-live-Acute Kidney Injury', 'Renal Insufficiency, Chronic-associated-HIV Infections', 'HIV Infections-associated-Renal Insufficiency, Chronic', 'Diabetes Mellitus-attenuate-Albuminuria', 'Diabetes Mellitus-attenuate-Kidney Diseases', 'Autoimmune Diseases-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-Autoimmune Diseases', 'Atrophy-promote-Stroke', 'Autoimmune Diseases-associated-Thyroiditis, Autoimmune', 'Thyroiditis, Autoimmune-associated-Autoimmune Diseases', 'Atrioventricular Block-aggravate-Heart Valve Diseases', 'Atrioventricular Block-predispose-Arrhythmias, Cardiac', 'Heart Valve Diseases-predispose-Arrhythmias, Cardiac', 'Death-lead-Critical Illness', 'Fractures, Bone-suffer-Osteoporosis', 'Anemia-improve-Acute Coronary Syndrome', 'Cartilage Diseases-associated-Ossification of Posterior Longitudinal Ligament', 'Ossification of Posterior Longitudinal Ligament-associated-Cartilage Diseases', 'Fasciculation-used-Amyotrophic Lateral Sclerosis', 'Mitochondrial Diseases-include-Pigmentation Disorders', 'Mitochondrial Diseases-exhibit-Pigmentation Disorders', 'Genetic Diseases, Inborn-cause-Mitochondrial Diseases', 'Genetic Diseases, Inborn-exhibit-Skin Diseases', 'Mitochondrial Diseases-exhibit-Skin Diseases', 'Rothmund-Thomson Syndrome-exhibit-Skin Diseases', 'Werner Syndrome-exhibit-Skin Diseases', 'Cockayne Syndrome-exhibit-Skin Diseases', 'Neoplasms-improve-Drug-Related Side Effects and Adverse Reactions', 'Vision Disorders-report-Headache Disorders, Secondary', 'Cataract-report-Headache Disorders, Secondary', 'Atrophy-accelerate-Delirium', 'Alzheimer Disease-accelerate-Delirium', 'Death-experience-Stroke', 'Death-limit-Chronic Disease', 'Alzheimer Disease-show-Neurodegenerative Diseases', 'Dementia-show-Neurodegenerative Diseases', 'Alzheimer Disease-lead-Nerve Degeneration', 'Neurogenic Inflammation-lead-Nerve Degeneration', 'Coronary Artery Disease-identified-Pulmonary Disease, Chronic Obstructive', 'Dementia-report-Pain', 'Facial Pain-collected-Dementia', 'Pain-evaluate-Dementia', 'Sarcopenia-described-Carcinoma, Pancreatic Ductal', 'Sarcopenia-described-Stroke', 'Pain-surround-Dementia', 'Dementia-experience-Pain', 'Communicable Diseases-associate-Neoplasms', 'Neoplasms-associate-Communicable Diseases', 'Surgical Wound Infection-avoid-Hip Fractures', 'Surgical Wound Infection-base-Infections', 'Seizures-associated-Nerve Degeneration', 'Nerve Degeneration-associated-Seizures', 'Death-decrease-Hodgkin Disease', 'Neoplasms-decrease-Pancreatic Neoplasms', 'Neoplasms-decrease-Multiple Myeloma', 'HIV Infections-examine-Metabolic Syndrome', 'Periodontal Diseases-include-Stomatognathic Diseases', 'Adenomatous Polyposis Coli-provide-Obesity', 'Adenomatous Polyposis Coli-provide-Diabetes Mellitus', 'Alzheimer Disease-relate-Metabolic Diseases', 'Alzheimer Disease-characterize-Metabolic Diseases', 'Communicable Diseases-prevent-Death', 'Proteinuria-predict-Hypertension', 'Alzheimer Disease-cause-Death', 'Heart Diseases-cause-Death', 'Periodontitis-dubbed-Brain Injuries', 'Periodontitis-affect-Pneumonia', 'Diabetes Mellitus, Type 2-associated-Hereditary Breast and Ovarian Cancer Syndrome', 'Hereditary Breast and Ovarian Cancer Syndrome-associated-Diabetes Mellitus, Type 2', 'Hereditary Breast and Ovarian Cancer Syndrome-screen-Diabetes Mellitus, Type 2', 'Asthma-show-Death', 'Bundle-Branch Block-associated-Hypertension', 'Hypertension-associated-Bundle-Branch Block', 'Headache Disorders, Secondary-treat-Cardiovascular Diseases', 'Headache Disorders, Secondary-treat-Dementia', 'Headache Disorders, Secondary-increase-Cardiovascular Diseases', 'Infections-cause-Fever', 'Infections-cause-Cough', 'Infections-cause-Fatigue', 'Fractures, Compression-result-Wounds and Injuries', 'Fractures, Compression-result-Osteoporosis', 'Fractures, Bone-result-Pain', 'Pain-focus-Weight Loss', 'Death-develop-Hyper-IgM Immunodeficiency Syndrome', 'Death-emerge-Kidney Diseases', 'Death-related-Carcinoma, Hepatocellular', 'Neoplasms-receive-Carcinoma, Hepatocellular', 'Huntington Disease-included-Kidney Failure, Chronic', 'Cardiomyopathy, Dilated-belong-Cardiomyopathies', 'Inflammation-occur-Cardiomyopathy, Dilated', 'Fractures, Bone-fund-Hip Fractures', 'Neoplasms-seen-Atherosclerosis', 'Neoplasms-seen-Alzheimer Disease', 'Neoplasms-seen-Diabetes Mellitus, Type 2', 'Neoplasms-seen-Renal Insufficiency, Chronic', 'Neoplasms-seen-Cardiovascular Diseases', 'Alzheimer Disease-influenced-Inflammation', 'Neoplasms-analyzed-Brain Neoplasms', 'Brain Neoplasms-analyzed-Neuroma, Acoustic', 'Musculoskeletal Diseases-represent-Neurodegenerative Diseases', 'Stiff-Person Syndrome-decrease-Neurodegenerative Diseases', 'Sarcopenia-use-Ataxia', 'Acute Kidney Injury-defined-Kidney Diseases', 'Hypertension-characterized-Hydrocephalus', 'Dementia-characterized-Hydrocephalus', 'Alcoholism-live-HIV Infections', 'HIV Infections-exacerbate-Neurotoxicity Syndromes', 'Alcoholism-reduce-Neurotoxicity Syndromes', 'Alcoholism-promote-Inflammation', 'Neurotoxicity Syndromes-attributed-Inflammation', 'HIV Infections-include-Alcoholism', 'Polycystic Ovary Syndrome-accompanied-Obesity', 'Polycystic Ovary Syndrome-accompanied-Diabetes Mellitus', 'Compartment Syndromes-alleviate-Pain', 'Infections-observed-Death', 'Metabolic Diseases-increase-Anemia', 'Metabolic Diseases-increase-Lung Neoplasms', 'Hyponatremia-increase-Anemia', 'Hyponatremia-increase-Lung Neoplasms', 'Hypokalemia-increase-Anemia', 'Hypokalemia-increase-Lung Neoplasms', 'Anemia-increase-Lung Neoplasms', 'Machado-Joseph Disease-known-Ataxia', 'Hypertension-report-Renal Insufficiency, Chronic', 'Infections-decrease-Death', 'Heart Diseases-result-Death', 'Heart Failure-underlie-Heart Diseases', 'Dental Caries-lead-Heart Arrest', 'Death-present-Angina, Stable', 'Cough-diagnosed-Pneumonia', 'Pneumonia-diagnosed-Pneumonia, Aspiration', 'Cough-diagnosed-Pneumonia, Aspiration', 'Sleep Wake Disorders-study-Pain', 'Epilepsy, Temporal Lobe-recruited-Epilepsy', 'Epilepsy-highlight-Epilepsy, Temporal Lobe', 'Mitochondrial Diseases-contribute-Fatigue', 'Intra-Abdominal Hypertension-link-Multiple Organ Failure', 'Ischemia-link-Multiple Organ Failure', 'Heart Failure-reveal-Death', 'Diabetes Mellitus-appear-Heart Failure', 'Death-appear-Heart Failure', 'Blindness-caused-Corneal Diseases', 'Pain-followed-Heart Diseases', 'Pain-followed-Hypertension', 'Pain-followed-Dyslipidemias', 'Pain-followed-Obesity', 'Vision Disorders-defined-Cataract', 'Cataract-follow-Glaucoma', 'Chronic Disease-progress-Pneumonia', 'Chronic Disease-progress-Multiple Organ Failure', 'Pneumonia-progress-Multiple Organ Failure', 'Chronic Disease-include-Stroke', 'Pleural Effusion-associated-Death', 'Death-associated-Pleural Effusion', 'Communicable Diseases-include-Diabetes Mellitus', 'Dementia-comprise-Death', 'Multiple Myeloma-monitored-Neoplasms', 'Death-monitored-Neoplasms', 'Tendinopathy-treat-Disease', 'Vision Disorders-reverse-Glaucoma', 'Mitochondrial Diseases-remain-Infections', 'Mitochondrial Diseases-remain-Neoplasms', 'Neoplasms-include-Anemia, Sickle Cell', 'Dementia-develop-Hallucinations', 'Delirium-precipitate-Hallucinations', 'Delirium-experience-Psychomotor Agitation', 'Hallucinations-experience-Psychomotor Agitation', 'Death-experience-Psychomotor Agitation', 'Neoplasms-develop-Cardiotoxicity', 'Obesity-defined-Ataxia', 'Obesity-display-Osteoarthritis', 'Sensation Disorders-associated-Death', 'Death-associated-Sensation Disorders', 'Vision Disorders-compare-Sensation Disorders', 'Hearing Loss-compare-Sensation Disorders', 'Death-documented-Colorectal Neoplasms', 'Amyloidosis-lead-Alzheimer Disease', 'Neoplasms-bathe-Carcinogenesis', 'Neoplasms-receive-Carcinogenesis', 'Meningitis, Bacterial-associated-Meibomian Gland Dysfunction', 'Meibomian Gland Dysfunction-associated-Meningitis, Bacterial', 'Drug-Related Side Effects and Adverse Reactions-associated-Meibomian Gland Dysfunction', 'Meibomian Gland Dysfunction-associated-Drug-Related Side Effects and Adverse Reactions', 'Death-reflect-Lupus Erythematosus, Systemic', 'Carcinoma, Merkel Cell-seen-Erythema Nodosum', 'Cerebral Amyloid Angiopathy-decrease-Cerebral Hemorrhage', 'Diabetes Mellitus-present-Coronary Artery Disease', 'Coronary Artery Disease-defined-Constriction, Pathologic', 'Ovarian Diseases-indicate-Ovarian Neoplasms', 'Cardiovascular Diseases-affect-Dementia', 'Leg Ulcer-injected-Ulcer', 'Epilepsy, Tonic-Clonic-reveal-Trigeminal Neuralgia', 'Seizures-reveal-Trigeminal Neuralgia', 'Hepatic Encephalopathy-develop-Osteoporotic Fractures', 'Renal Insufficiency, Chronic-affect-Stroke', 'Renal Insufficiency, Chronic-share-Hypertension', 'Renal Insufficiency, Chronic-explore-Stroke', 'Coronary Artery Disease-identified-Malocclusion', 'Lung Diseases-reveal-Pneumonia, Aspiration', 'Cerebrovascular Disorders-reveal-Pneumonia, Aspiration', 'Dementia-follow-Coronary Artery Disease', 'Sarcopenia-tend-Death', 'Multiple Sclerosis-characterized-Demyelinating Diseases', 'Neurodegenerative Diseases-characterized-Demyelinating Diseases', 'Deglutition Disorders-contribute-Weight Loss', 'Deglutition Disorders-cause-Weight Loss', 'Death-predict-Heart Failure', 'Hypertension, Pulmonary-extended-Cachexia', 'Hypertension, Pulmonary-extended-Cardiomyopathy, Hypertrophic', 'Hypertension, Pulmonary-extended-Ventricular Dysfunction', 'Hypertension, Pulmonary-extended-Hypertension', 'Hypertension-extended-Cachexia', 'Hypertension-extended-Cardiomyopathy, Hypertrophic', 'Hypertension-extended-Ventricular Dysfunction', 'Sarcopenia-characterized-Inflammation', 'Sarcopenia-characterized-Mitochondrial Diseases', 'Fractures, Bone-treat-Postpartum Hemorrhage', 'Muscle Weakness-defined-Dementia', 'Hypogonadism-caused-Immunologic Deficiency Syndromes', 'Infertility, Female-described-Fallopian Tube Diseases', 'Inflammation-facilitate-Neoplasms', 'Infections-followed-Cerebrovascular Disorders', 'Genetic Diseases, Inborn-present-Nervous System Diseases', 'Sleep Wake Disorders-prescribed-Fractures, Bone', 'Sleep Wake Disorders-prescribed-Hip Fractures', 'Sleep Wake Disorders-prescribed-Cerebral Infarction', 'Malnutrition-moderated-Pain', 'Sleep Initiation and Maintenance Disorders-assessed-Cardiac Output, Low', 'Sleep Initiation and Maintenance Disorders-predict-Pain', 'Coronary Occlusion-benefit-Hypotension', 'Pneumonia-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-Pneumonia', 'Pneumonia-associated-HIV Infections', 'HIV Infections-associated-Pneumonia', 'Cardiovascular Diseases-compare-HIV Infections', 'Cardiovascular Diseases-compare-Death', 'HIV Infections-uninfected-Cardiovascular Diseases', 'HIV Infections-uninfected-Death', 'Communicable Diseases-concern-Respiratory Tract Infections', 'Communicable Diseases-concern-Gastroenteritis', 'Communicable Diseases-concern-Edema', 'Communicable Diseases-concern-Dehydration', 'Dementia-face-Death', 'Diabetes Mellitus-result-Headache Disorders, Secondary', 'Heart Failure-observed-Diabetes Mellitus', 'Hemorrhage-tolerate-Hypotension', 'Heart Arrest-illuminate-Multiple Myeloma', 'Respiratory Insufficiency-caused-Pneumonia', 'Obesity-related-Renal Insufficiency, Chronic', 'Sarcopenia-accord-Obesity', 'Neoplasms-consider-Pelvic Floor Disorders', 'Choledocholithiasis-complicate-Pancreatitis', 'Choledocholithiasis-complicate-Cholangitis', 'Diverticulitis-present-Abdominal Pain', 'Colitis-associated-Diverticulum', 'Diverticulum-associated-Colitis', 'Death-admitted-Delirium', 'Fractures, Bone-report-Pain, Postoperative', 'Adenocarcinoma-associated-Kidney Failure, Chronic', 'Kidney Failure, Chronic-associated-Adenocarcinoma', 'Fibrosis-associated-Kidney Failure, Chronic', 'Kidney Failure, Chronic-associated-Fibrosis', 'Diarrhea-got-Myalgia', 'Dysentery-got-Myalgia', 'Dementia-enrolled-Alzheimer Disease', 'Colorectal Neoplasms-increase-Cardiovascular Abnormalities', 'Multiple Organ Failure-predict-Death', 'Respiratory Tract Infections-include-Death', 'Sepsis-compared-Death', 'Death-undergo-Cerebral Infarction', 'Neuroma, Acoustic-include-Hearing Loss, Central', 'Neuroma, Acoustic-include-Tinnitus', 'Neuroma, Acoustic-include-Nervous System Diseases', 'Neoplasms-affected-Neuroma, Acoustic', 'Neoplasms-include-Hearing Loss, Central', 'Neoplasms-include-Tinnitus', 'Neoplasms-include-Nervous System Diseases', 'Neuroma, Acoustic-based-Neoplasms', 'Neuroma, Acoustic-based-Hearing Loss', 'Diabetes Mellitus-recognized-Death', 'Diabetes Mellitus-hospitalized-Pneumonia', 'Hip Fractures-indicated-Pain, Postoperative', 'Pain-occur-Hip Fractures', 'Stroke-examine-Hypertension', 'Stroke-examine-Atrial Fibrillation', 'Stroke-found-Hypertension', 'Obesity-induce-Muscular Diseases', 'Headache Disorders, Secondary-include-Neurodegenerative Diseases', 'Hemolytic-Uremic Syndrome-undergo-Calcinosis', 'Hemolytic-Uremic Syndrome-characterized-Calcinosis', 'Stroke-use-Renal Insufficiency, Chronic', 'Arthritis-associated-Sarcopenia', 'Sarcopenia-associated-Arthritis', 'Rheumatic Diseases-associated-Sarcopenia', 'Sarcopenia-associated-Rheumatic Diseases', 'Blood Coagulation Disorders, Inherited-seen-Sepsis', 'Disseminated Intravascular Coagulation-seen-Sepsis', 'Lupus Erythematosus, Systemic-characterized-Lymphopenia', 'Communicable Diseases-guide-Lupus Erythematosus, Systemic', 'Coronavirus Infections-protect-Death', 'Carcinogenesis-classified-Neoplasms', 'Immune System Diseases-studied-Infections', 'Pneumonia-develop-Critical Illness', 'Rheumatic Diseases-affect-Inflammation', 'Rheumatic Diseases-characterized-Inflammation', 'Muscular Dystrophy, Duchenne-associated-Death', 'Death-associated-Muscular Dystrophy, Duchenne', 'Muscular Dystrophy, Duchenne-associated-Oculocerebrorenal Syndrome', 'Oculocerebrorenal Syndrome-associated-Muscular Dystrophy, Duchenne', 'Critical Illness-followed-Death', 'Atrophy-attributed-Muscular Diseases', 'Pneumonia-underlie-Respiratory Tract Diseases', 'Osteoporosis-avert-Fractures, Bone', 'Death-avert-Fractures, Bone', 'Osteoporosis-combine-Osteoporotic Fractures', 'Fractures, Bone-combine-Osteoporotic Fractures', 'Alzheimer Disease-trigger-Nerve Degeneration', 'Carcinoma, Hepatocellular-determine-Fibrosis', 'Fibrosis-live-HIV Infections', 'Carcinoma, Hepatocellular-live-HIV Infections', 'Coronary Artery Disease-associated-Arteriosclerosis', 'Arteriosclerosis-associated-Coronary Artery Disease', 'Neurodegenerative Diseases-speculate-Multiple Sclerosis', 'Neurodegenerative Diseases-speculate-Alzheimer Disease', 'Multiple Sclerosis-speculate-Alzheimer Disease', 'Multiple Sclerosis-associated-Alzheimer Disease', 'Alzheimer Disease-associated-Multiple Sclerosis', 'Idiopathic Pulmonary Fibrosis-stratified-Death', 'Neurodegenerative Diseases-cause-Alzheimer Disease', 'Aneuploidy-include-Heart Failure', 'Aneuploidy-proposed-Heart Failure', 'Aneuploidy-associated-Obesity', 'Obesity-associated-Aneuploidy', 'Aneuploidy-found-Obesity', 'Neoplasms-considered-Endometrial Neoplasms', 'Liposarcoma-associated-Sarcoma', 'Sarcoma-associated-Liposarcoma', 'Sarcoma-play-Liposarcoma', 'Alzheimer Disease-function-Sensation Disorders', 'Neoplasms-experience-Inflammation', 'HIV Infections-stratified-Lymphoma, Non-Hodgkin', 'Hip Fractures-include-Cardiac Output, Low', 'Epilepsy-associated-Atrophy', 'Atrophy-associated-Epilepsy', 'Atrophy-find-Epilepsy, Temporal Lobe', 'Epilepsy-prevent-Atrophy', 'Epilepsy-observed-Epilepsy, Temporal Lobe', 'Atrophy-observed-Epilepsy, Temporal Lobe', 'Epilepsy-prevent-Brain Injuries, Diffuse', 'Seizures-normalize-Atrophy', 'Brain Injuries, Diffuse-prevent-Epilepsy, Temporal Lobe', 'Osteoporosis-influence-Kidney Neoplasms', 'Mastocytosis, Systemic-influence-Kidney Neoplasms', 'Sarcopenia-defined-Weight Loss', 'Weight Loss-defined-Muscular Diseases', 'Pyuria-modified-Renal Insufficiency, Chronic', 'Kidney Failure, Chronic-modified-Renal Insufficiency, Chronic', 'Pyuria-increase-Kidney Failure, Chronic', 'Pyuria-correlated-Diabetes Mellitus', 'Pyuria-increase-Death', 'Pyuria-correlated-Hypoalbuminemia', 'Pyuria-correlated-Inflammation', 'Inflammation-caused-Mitochondrial Diseases', 'Inflammation-cause-Pneumonia', 'Inflammation-cause-Multiple Organ Failure', 'Inflammation-cause-Death', 'Mitochondrial Diseases-cause-Pneumonia', 'Mitochondrial Diseases-cause-Multiple Organ Failure', 'Mitochondrial Diseases-cause-Death', 'Takotsubo Cardiomyopathy-ascribe-Coronary Vasospasm', 'Takotsubo Cardiomyopathy-involve-Vascular System Injuries', 'Death-revealed-Atrial Fibrillation', 'Death-revealed-Renal Insufficiency', 'Stroke-lead-Neurodegenerative Diseases', 'Dysbiosis-result-Obesity', 'Dysbiosis-associated-Metabolic Diseases', 'Metabolic Diseases-associated-Dysbiosis', 'Dysbiosis-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-Dysbiosis', 'Dysbiosis-associated-Sleep Wake Disorders', 'Sleep Wake Disorders-associated-Dysbiosis', 'Dysbiosis-implicated-Cerebrovascular Disorders', 'Dysbiosis-result-Dementia', 'Obesity-associated-Dysbiosis', 'Dysbiosis-associated-Obesity', 'Ulcer-develop-Wounds and Injuries', 'Dyslipidemias-include-Atherosclerosis', 'Tooth Loss-trigger-Dementia', 'Tooth Loss-found-Neurodegenerative Diseases', 'Tooth Loss-found-Alzheimer Disease', 'Arterial Occlusive Diseases-trigger-Dementia', 'Arterial Occlusive Diseases-found-Neurodegenerative Diseases', 'Arterial Occlusive Diseases-found-Alzheimer Disease', 'Dementia-found-Neurodegenerative Diseases', 'HIV Infections-experience-Neoplasms', 'HIV Infections-experience-Cardiovascular Diseases', 'Chronic Pain-aimed-HIV Infections', 'HIV Infections-aimed-Pain', 'Chronic Pain-aimed-Pain', 'HIV Infections-live-Pain', 'Hodgkin Disease-eradicate-Lymphoma', 'Hodgkin Disease-improve-Drug-Related Side Effects and Adverse Reactions', 'Death-tested-Chronic Disease', 'Lung Diseases-identify-Fractures, Bone', 'Heart Diseases-develop-Arrhythmias, Cardiac', 'Neoplasms-support-Dementia', 'Dementia-required-Neoplasms', 'Dementia-enable-Neoplasms', 'Dementia-undergo-Neoplasms', 'Dementia-navigate-Neoplasms', 'Dementia-feel-Neoplasms', 'Death-require-Cardiac Output, Low', 'Death-require-Wounds and Injuries', 'Cardiac Output, Low-require-Wounds and Injuries', 'Fractures, Bone-remain-Musculoskeletal Diseases', 'Cardiovascular Diseases-develop-Death', 'Cardiovascular Diseases-pose-Neoplasms', 'HIV Infections-compare-Death', 'HIV Infections-find-Lung Neoplasms', 'HIV Infections-find-Colorectal Neoplasms', 'Onchocerciasis-known-Blindness', 'Hyperemia-assessed-Ischemia', 'Drug Hypersensitivity-documented-Skin Diseases', 'Periodontal Diseases-associated-Atherosclerosis', 'Atherosclerosis-associated-Periodontal Diseases', 'Lewy Body Disease-accompanied-Gastrointestinal Diseases', 'Lewy Body Disease-accompanied-Constipation', 'Quadriplegia-fall-Cardiac Output, Low', 'Cerebral Small Vessel Diseases-assessed-Stroke, Lacunar', 'Diabetes Mellitus, Type 2-improve-Atherosclerosis', 'Genetic Diseases, Inborn-cause-Bone Marrow Failure Disorders', 'Genetic Diseases, Inborn-cause-Leukemia', 'Neoplasms-improve-Atherosclerosis', 'Diabetes Mellitus-associated-Hypoalphalipoproteinemias', 'Hypoalphalipoproteinemias-associated-Diabetes Mellitus', 'Metabolic Syndrome-associated-Hypoalphalipoproteinemias', 'Hypoalphalipoproteinemias-associated-Metabolic Syndrome', 'Hyperglycemia-investigated-Necrosis', 'Death-associated-Cardiac Complexes, Premature', 'Cardiac Complexes, Premature-associated-Death', 'Leishmaniasis-comprise-Zoonoses', 'Zoonoses-belong-Leishmaniasis', 'Death-get-Neoplasms', 'Fatigue-fatigue-Mutism', 'Pain-compare-Osteoarthritis', 'Pain-compare-Arthritis, Rheumatoid', 'Mitochondrial Diseases-cause-Respiratory Insufficiency', 'Acute Pain-caused-Spinal Cord Injuries', 'Quadriplegia-caused-Spinal Cord Injuries', 'Obesity-experience-Malnutrition', 'Diabetes Mellitus-experience-Malnutrition', 'Sarcopenia-experience-Malnutrition', 'Ischemia-taken-Thrombosis', 'Thrombosis-related-Coronavirus Infections', 'Inflammation-seem-Adenocarcinoma', 'Muscle Weakness-increase-Fractures, Bone', 'Nervous System Diseases-analyzed-Stroke', 'Nervous System Diseases-analyzed-Alzheimer Disease', 'Nervous System Diseases-analyzed-Dementia', 'Nervous System Diseases-analyzed-Parkinson Disease', 'Nervous System Diseases-analyzed-Epilepsy', 'Nervous System Diseases-analyzed-Multiple Sclerosis', 'Nervous System Diseases-analyzed-Motor Neuron Disease', 'Nervous System Diseases-analyzed-Migraine Disorders', 'Nervous System Diseases-analyzed-Headache', 'Nervous System Diseases-analyzed-Brain Injuries, Traumatic', 'Nervous System Diseases-analyzed-Spinal Cord Injuries', 'Nervous System Diseases-analyzed-Neoplasms', 'Nervous System Diseases-analyzed-Meningitis', 'Nervous System Diseases-analyzed-Encephalitis', 'Nervous System Diseases-analyzed-Tetany', 'HIV Infections-share-Alzheimer Disease', 'Xerostomia-correlated-Diabetes Mellitus', 'Cerebral Infarction-observed-Heart Failure', 'Sarcopenia-represent-Muscular Atrophy', 'Sarcopenia-suffer-Fractures, Bone', 'Sarcopenia-suffer-Metabolic Diseases', 'Sarcopenia-faced-Death', 'Sarcopenia-describe-Muscular Atrophy', 'Sarcopenia-describe-Muscular Disorders, Atrophic', 'Coma-associated-Thrombosis', 'Thrombosis-associated-Coma', 'Blindness-cause-Vision Disorders', 'Headache-lead-Death', 'HIV Infections-improve-Hypogonadism', 'HIV Infections-emerge-Osteoporosis', 'Pain-seen-Osteoarthritis', 'Hyperglycemia-characterized-Diabetic Angiopathies', 'Hepatitis C-associated-Stenosis, Pulmonary Artery', 'Stenosis, Pulmonary Artery-associated-Hepatitis C', 'Hepatitis C-associated-Hypertension, Pulmonary', 'Hypertension, Pulmonary-associated-Hepatitis C', 'Sarcopenia-include-Ataxia', 'Diabetes Mellitus-underlie-Hypertension', 'Neoplasms-underlie-Hypertension', 'Infections-underlie-Hypertension', 'Cluster Headache-underlie-Hypertension', 'Ulcer-become-Death', 'Ulcer-cause-Death', 'Alzheimer Disease-elaborate-Proteostasis Deficiencies', 'Dementia-caused-Ulcer', 'Weight Loss-accompanied-Fatty Liver', 'Weight Loss-accompanied-Inflammation', 'Neurodegenerative Diseases-cause-Death', 'Dyspnea-identified-Kidney Diseases, Cystic', 'Fever-identified-Kidney Diseases, Cystic', 'Liver Failure-prepare-Infections', 'Jaundice-identified-Kidney Diseases, Cystic', 'Acute Kidney Injury-associated-Arbovirus Infections', 'Arbovirus Infections-associated-Acute Kidney Injury', 'HIV Infections-include-Arbovirus Infections', 'Infections-associated-Acute Kidney Injury', 'Acute Kidney Injury-associated-Infections', 'Acute Kidney Injury-occur-Infections', 'Infections-range-Carcinoma', 'Cardiovascular Diseases-appear-Severe Acute Respiratory Syndrome', 'Severe Acute Respiratory Syndrome-underpin-Arbovirus Infections', 'Infections-range-Respiratory Tract Diseases', 'Diabetes Mellitus-appear-Severe Acute Respiratory Syndrome', 'HIV Infections-reflect-Immune System Diseases', 'HIV Infections-observed-Immune System Diseases', 'Ocular Hypertension-compound-Corneal Diseases', 'Ocular Hypertension-associated-Headache Disorders, Secondary', 'Headache Disorders, Secondary-associated-Ocular Hypertension', 'Corneal Diseases-compound-Headache Disorders, Secondary', 'Liver Failure-identify-Gastrointestinal Diseases', 'Alzheimer Disease-increase-Dementia', 'Alzheimer Disease-range-Dementia', 'Inflammation-play-Parkinson Disease', 'Demyelinating Diseases-cause-Muscle Weakness', 'Demyelinating Diseases-cause-Hypesthesia', 'Demyelinating Diseases-cause-Gait Ataxia', 'Diabetic Neuropathies-reported-Polyneuropathies', 'Neoplasms-identified-Venous Thromboembolism', 'Cardiovascular Diseases-pose-Death', 'Atherosclerosis-experience-Ischemia', 'Ischemia-experience-Hyperlipoproteinemia Type II', 'Ischemia-experience-Diabetes Mellitus', 'Pulmonary Heart Disease-associated-Osteoporosis', 'Osteoporosis-associated-Pulmonary Heart Disease', 'Pulmonary Heart Disease-associated-Pulmonary Disease, Chronic Obstructive', 'Pulmonary Disease, Chronic Obstructive-associated-Pulmonary Heart Disease', 'Chest Pain-visit-Fatigue', 'Dyspnea-visit-Fatigue', 'Diabetes Mellitus-decrease-Vitreous Hemorrhage', 'Metabolic Syndrome-control-Neoplasms', 'Hyperglycemia-control-Hypoglycemia', 'Neurodegenerative Diseases-facilitate-Death', 'Neurodegenerative Diseases-activate-Alzheimer Disease', 'Hyperlipidemias-follow-Hypertension', 'Critical Illness-defined-Death', 'Pelvic Neoplasms-associate-Death', 'Death-associate-Pelvic Neoplasms', 'Eye Infections-treated-Conjunctivitis', 'Hemorrhage-influenced-Hemophilia A', 'Critical Illness-observe-AIDS Arteritis, Central Nervous System', 'Cerebral Amyloid Angiopathy-include-Cerebral Small Vessel Diseases', 'Blister-show-Seizures', 'Obesity-associated-Hypotension', 'Hypotension-associated-Obesity', 'Cardiovascular Diseases-diverge-Hypertension', 'Obesity-associate-Hip Fractures', 'Hip Fractures-associate-Obesity', 'Pulmonary Embolism-show-Death', 'Skin Diseases-known-Aneuploidy', 'Hemorrhage-increase-Death', 'Chronic Disease-exacerbated-Spinal Fractures', 'Osteoporosis-defined-Muscular Dystrophy, Duchenne', 'Osteoporosis-defined-Osteoporotic Fractures', 'Neoplasms-associated-Hemangioblastoma', 'Hemangioblastoma-associated-Neoplasms', 'von Hippel-Lindau Disease-associated-Hemangioblastoma', 'Hemangioblastoma-associated-von Hippel-Lindau Disease', 'Muscular Dystrophy, Duchenne-matched-Osteoporotic Fractures', 'Cataract-report-Capsule Opacification', 'Dementia-challenge-Communication Disorders', 'Neoplasms-suffer-Alzheimer Disease', 'Neoplasms-provide-Death', 'Genetic Diseases, Inborn-characterized-Cataract', 'Genetic Diseases, Inborn-characterized-Dyslipidemias', 'Genetic Diseases, Inborn-characterized-Osteoporosis', 'Genetic Diseases, Inborn-characterized-Atherosclerosis', 'Williams Syndrome-show-Diabetes Mellitus', 'Williams Syndrome-show-Thyroid Diseases', 'Williams Syndrome-show-Hyperlipidemias', 'Deglutition Disorders-divided-Sarcopenia', 'Tuberculosis, Osteoarticular-occur-Arthritis, Rheumatoid', 'Arthritis, Rheumatoid-admitted-Fatigue', 'Infections-discuss-Inflammation', 'Proteostasis Deficiencies-participate-Parkinson Disease', 'Drug-Related Side Effects and Adverse Reactions-lead-Kidney Diseases', 'Cardiac Output, Low-assessed-Williams Syndrome', 'Ovarian Diseases-compare-Ovarian Neoplasms', 'Kidney Diseases-associated-Hip Fractures', 'Hip Fractures-associated-Kidney Diseases', 'Dementia-associated-Hip Fractures', 'Hip Fractures-associated-Dementia', 'Parkinson Disease-associated-Hip Fractures', 'Hip Fractures-associated-Parkinson Disease', 'Death-compare-Vision Disorders', 'Alzheimer Disease-increase-Infections', 'Heterotaxy Syndrome-used-Atrial Fibrillation', 'Atrial Fibrillation-occur-Renal Insufficiency, Chronic', 'Arrhythmias, Cardiac-occur-Renal Insufficiency, Chronic', 'Heterotaxy Syndrome-minimize-Hemorrhage', 'Cardiovascular Diseases-related-Death', 'Zoonoses-occur-Infections', 'Inflammation-induce-Infections', 'Death-increase-Brain Injuries, Traumatic', 'Wounds and Injuries-increase-Brain Injuries, Traumatic', 'Death-undergo-Aortic Aneurysm, Thoracic', 'Hematoma-include-Cerebral Hemorrhage', 'Nervous System Diseases-include-Cerebral Hemorrhage', 'Diabetes Mellitus-grow-Cataract', 'Sarcopenia-act-Death', 'Heart Failure-result-Sarcopenia', 'Arrhythmias, Cardiac-identify-Myocardial Infarction', 'Hypertension-defined-Diabetes Mellitus', 'Death-follow-Infections', 'Mitochondrial Diseases-associated-Death', 'Death-associated-Mitochondrial Diseases', 'Dementia-defined-Death', 'Death-combined-Pulmonary Disease, Chronic Obstructive', 'Neurodegenerative Diseases-focus-Parkinson Disease, Secondary', 'Neurodegenerative Diseases-focus-Dementia, Vascular', 'Neurodegenerative Diseases-focus-Amyotrophic Lateral Sclerosis', 'Cataract-follow-Osteoarthritis', 'Cataract-follow-Epilepsy', 'Cataract-follow-Dementia', 'HIV Infections-increasing-Renal Insufficiency, Chronic', 'Prostatitis-point-Infections', 'Prostatitis-address-Chronic Disease', 'Prostatitis-develop-Chronic Disease', 'Dementia-compare-Oculocerebrorenal Syndrome', 'Arthritis-emerge-Diabetes Mellitus', 'Arthritis-emerge-Angina Pectoris', 'Arthritis-emerge-Stroke', 'Obesity-experience-Angina Pectoris', 'Liver Cirrhosis-require-Shock, Septic', 'Liver Cirrhosis-require-Respiratory Distress Syndrome', 'Liver Cirrhosis-require-Acute Kidney Injury', 'Diabetes Mellitus-found-Liver Cirrhosis', 'Vision Disorders-become-Blindness', 'Neurodegenerative Diseases-prevent-Alzheimer Disease', 'Autoimmune Diseases-remain-Arthritis, Rheumatoid', 'Metabolic Diseases-involve-Cardiovascular Diseases', 'Prostatic Diseases-involve-Cardiovascular Diseases', 'Hyperthyroidism-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-Hyperthyroidism', 'Epilepsies, Partial-involve-Cardiovascular Diseases', 'Hyperthyroidism-associated-Neoplasms', 'Neoplasms-associated-Hyperthyroidism', 'Hypothyroidism-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-Hypothyroidism', 'Metabolic Diseases-involve-Stroke', 'Hypothyroidism-associated-Neoplasms', 'Neoplasms-associated-Hypothyroidism', 'Prostatic Diseases-involve-Stroke', 'Epilepsies, Partial-involve-Stroke', 'Diabetes Mellitus-describe-Carcinoma, Hepatocellular', 'Neoplasms-describe-Carcinoma, Hepatocellular', 'Kidney Failure, Chronic-underlie-Viremia', 'Mitochondrial Diseases-sensitize-Heart Diseases', 'Hemolytic-Uremic Syndrome-affect-Renal Insufficiency, Chronic', 'Astrocytoma-include-Glioma', 'Glioblastoma-include-Glioma', 'Colitis-maintain-Colonic Neoplasms', 'Eye Diseases-followed-Headache', 'Eye Diseases-increase-Adrenal Insufficiency', 'Headache-increase-Adrenal Insufficiency', 'Adrenal Insufficiency-increase-Diabetes Insipidus', 'Neoplasms-hast-Death', 'Dementia-share-Metabolic Diseases', 'Blood Coagulation Disorders-characterized-Disseminated Intravascular Coagulation', 'Infections-produce-Hypoxia', 'Drug Resistant Epilepsy-refer-Ischemia', 'Drug Resistant Epilepsy-refer-Coronary Artery Disease', 'Hyperlipidemias-associated-Death', 'Death-associated-Hyperlipidemias', 'Dementia-constitute-Death', 'Diabetes Mellitus-constitute-Death', 'Kidney Diseases-constitute-Death', 'Tendinopathy-influence-Ankle Injuries', 'Stroke-increase-Diabetes Mellitus', 'Stroke-increase-Obesity', 'Stroke-increase-Hyperlipidemias', 'Hypertension-increase-Coronary Artery Disease', 'Diabetes Mellitus-increase-Coronary Artery Disease', 'Obesity-increase-Coronary Artery Disease', 'Hyperlipidemias-increase-Coronary Artery Disease', 'Osteoarthritis-develop-Arthritis, Rheumatoid', 'Osteoarthritis-diagnosed-Pleural Effusion', 'Osteoarthritis-progress-Arthritis, Rheumatoid', 'Pleural Effusion-progress-Arthritis, Rheumatoid', 'Neoplasms-differ-Neoplasms, Second Primary', 'Colorectal Neoplasms, Hereditary Nonpolyposis-occur-Neoplasms', 'Low Back Pain-experience-Pain', 'Colorectal Neoplasms, Hereditary Nonpolyposis-manifest-Neoplasms', 'Colorectal Neoplasms, Hereditary Nonpolyposis-occur-Adenomatous Polyposis Coli', 'Colorectal Neoplasms, Hereditary Nonpolyposis-associated-Neoplasms', 'Neoplasms-associated-Colorectal Neoplasms, Hereditary Nonpolyposis', 'Neoplasms-manifest-Adenomatous Polyposis Coli', 'Death-correlate-Heart Failure', 'Fecal Incontinence-increase-Death', 'Sarcopenia-compare-Inflammation', 'Neoplasms-associated-Neoplastic Syndromes, Hereditary', 'Neoplastic Syndromes, Hereditary-associated-Neoplasms', 'Fractures, Bone-associated-Ankle Fractures', 'Ankle Fractures-associated-Fractures, Bone', 'Fractures, Bone-related-Pain', 'Renal Insufficiency, Chronic-slow-Dementia', 'Anemia-slow-Dementia', 'Alzheimer Disease-include-Memory Disorders', 'Alzheimer Disease-include-Language Disorders', 'Skin Neoplasms-linked-Melanoma', 'Melanoma-linked-Alzheimer Disease', 'Alzheimer Disease-make-Neoplasms', 'Fibrosis-regulate-Myocardial Infarction', 'Fibrosis-attenuate-Myocardial Infarction', 'Back Pain-defined-Pain', 'Stroke-understand-Leukoencephalopathies', 'Diabetes Mellitus-indicate-Inflammation', 'Stroke-target-Inflammation', 'Neurodegenerative Diseases-warrant-Sleep Apnea, Obstructive', 'Stroke-selected-Cerebral Infarction', 'Fractures, Bone-attributed-Wounds and Injuries', 'Genetic Diseases, Inborn-occur-Musculoskeletal Diseases', 'Genetic Diseases, Inborn-occur-Neoplasms', 'Genetic Diseases, Inborn-occur-Asthma', 'Neoplasms-experience-Neurodegenerative Diseases', 'Neoplasms-develop-Hypertension', 'Neoplasms-develop-Dyslipidemias', 'Neoplasms-develop-Diabetes Mellitus', 'Neoplasms-develop-Asthma', 'Neoplasms-develop-Osteoarthritis', 'Death-coded-Malocclusion', 'Brain Injuries, Traumatic-associated-Gait Disorders, Neurologic', 'Gait Disorders, Neurologic-associated-Brain Injuries, Traumatic', 'Brain Injuries, Traumatic-shown-Gait Disorders, Neurologic', 'Alzheimer Disease-rank-Heart Diseases', 'Alzheimer Disease-rank-Neoplasms', 'Sarcopenia-noted-Dementia', 'Respiratory Tract Diseases-accounted-Death', 'Cardiovascular Diseases-accounted-Death', 'Neoplasms-accounted-Death', 'Sarcopenia-investigate-Albuminuria', 'Kidney Diseases-complicated-Cachexia', 'Atrial Fibrillation-compare-Stroke', 'Carcinoma, Non-Small-Cell Lung-shown-Death', 'Carcinoma, Non-Small-Cell Lung-shown-Neurodegenerative Diseases', 'Cardiovascular Diseases-involved-Death', 'Parkinson Disease-ameliorate-Gait Disorders, Neurologic', 'Cardiovascular Diseases-endanger-Death', 'Nervous System Diseases-rank-Cardiovascular Diseases', 'Nervous System Diseases-rank-Neoplasms', 'Nervous System Diseases-represent-Death', 'Death-found-Pneumonia', 'Diabetes Mellitus-complicated-HIV Infections', 'Osteoarthritis-considered-Cumulative Trauma Disorders', 'Cumulative Trauma Disorders-result-Inflammation', 'Pain-begin-Osteoarthritis', 'Heart Diseases-associated-Osteoarthritis', 'Osteoarthritis-associated-Heart Diseases', 'Kidney Diseases-associated-Osteoarthritis', 'Osteoarthritis-associated-Kidney Diseases', 'Pain-compare-Trigeminal Neuralgia', 'Death-present-Coma', 'Coma-present-Blood Coagulation Disorders', 'Neoplasms-include-Infections', 'Lymphopenia-aggravate-Neoplasms', 'Neurodegenerative Diseases-demonstrate-Neoplasms', 'Venous Thrombosis-manage-Neoplasms', 'Thromboembolism-recommend-Atrial Fibrillation', 'Kidney Diseases-increase-Hemorrhage', 'Renal Insufficiency, Chronic-increase-Hemorrhage', 'Memory Disorders-mediated-Communicable Diseases', 'End Stage Liver Disease-promote-Heart Diseases', 'End Stage Liver Disease-promote-Arrhythmias, Cardiac', 'End Stage Liver Disease-affect-Cardiovascular Diseases', 'End Stage Liver Disease-promote-Cardiomyopathies', 'Cardiovascular Diseases-affect-Liver Diseases', 'End Stage Liver Disease-range-Hypertension, Pulmonary', 'End Stage Liver Disease-promote-Renal Insufficiency', 'End Stage Liver Disease-promote-Ascites', 'End Stage Liver Disease-promote-Brain Diseases', 'Heart Diseases-range-Hypertension, Pulmonary', 'Corneal Diseases-increased-Astigmatism', 'Arrhythmias, Cardiac-range-Hypertension, Pulmonary', 'Cardiomyopathies-range-Hypertension, Pulmonary', 'Hypertension, Pulmonary-range-Renal Insufficiency', 'Hypertension, Pulmonary-range-Ascites', 'Hypertension, Pulmonary-range-Brain Diseases', 'Hypokalemia-result-Death', 'Muscle Weakness-result-Death', 'Hip Fractures-continue-Wounds and Injuries', 'Hip Fractures-exclude-Fractures, Bone', 'Death-seen-Cardiovascular Diseases', 'Inflammation-become-Communicable Diseases', 'Neoplasms-become-Communicable Diseases', 'Osteoarthritis-identified-Pain', 'Seizures-mediate-Sarcopenia', 'Obesity-mediate-Sarcopenia', 'Seizures-mediated-Sarcopenia', 'Sarcopenia-mediated-Obesity', 'Infections-analyzed-Onychomycosis', 'Death-stratified-Diabetes Mellitus', 'Dementia-completed-Pain', 'Adenoma-influence-Colorectal Neoplasms', 'Tinnitus-understand-Hearing Loss', 'Hearing Loss-found-Tinnitus', 'Muscular Disorders, Atrophic-differ-HIV Infections', 'Calcinosis-include-Atrial Fibrillation', 'Inflammation-suspected-Hematologic Neoplasms', 'Inflammation-increase-Hematologic Neoplasms', 'Anemia, Sickle Cell-include-Hemolysis', 'Anemia, Sickle Cell-include-Aneurysm', 'Thyroid Neoplasms-associated-Infections', 'Infections-associated-Thyroid Neoplasms', 'Infections-associated-Lung Neoplasms', 'Lung Neoplasms-associated-Infections', 'Diabetes Mellitus-detect-Edema', 'Non-alcoholic Fatty Liver Disease-result-Fatty Liver', 'Non-alcoholic Fatty Liver Disease-result-Inflammation', 'Non-alcoholic Fatty Liver Disease-result-Fibrosis', 'Adenoma-account-Salivary Gland Neoplasms', 'Dermatitis, Atopic-include-Skin Diseases', 'Hypertension-observed-Metabolic Diseases', 'Pain-defined-Nociceptive Pain', 'Pain-defined-Neuralgia', 'Diabetes Mellitus-use-Pain', 'Delirium-related-Stroke', 'Delirium-related-Dementia', 'Stroke-observed-Dementia', 'Stroke-include-Adrenal Insufficiency', 'Non-alcoholic Fatty Liver Disease-evaluate-Myotonic Dystrophy', 'Non-alcoholic Fatty Liver Disease-associated-Diabetes Mellitus, Type 2', 'Diabetes Mellitus, Type 2-associated-Non-alcoholic Fatty Liver Disease', 'Non-alcoholic Fatty Liver Disease-associated-Myotonic Dystrophy', 'Myotonic Dystrophy-associated-Non-alcoholic Fatty Liver Disease', 'Iron Metabolism Disorders-lead-Death', 'Neurodegenerative Diseases-discuss-Drug-Related Side Effects and Adverse Reactions', 'Delirium-found-Neoplasms', 'Cough-prevent-Pneumonia', 'Cough-prevent-Death', 'Cough-prevent-Parkinson Disease', 'Parkinson Disease-demonstrate-Cough', 'Lymphoma, T-Cell-acquired-Metabolism, Inborn Errors', 'Lymphoma, T-Cell-required-Neoplasms', 'Metabolism, Inborn Errors-required-Neoplasms', 'Obesity, Abdominal-associated-Prediabetic State', 'Prediabetic State-associated-Obesity, Abdominal', 'Prediabetic State-associated-Hypertension', 'Hypertension-associated-Prediabetic State', 'Cardiovascular Diseases-associated-Prediabetic State', 'Prediabetic State-associated-Cardiovascular Diseases', 'Arthralgia-diagnosed-Osteoarthritis', 'Respiratory Tract Diseases-lead-Pneumonia', 'Breast Neoplasms-focus-Neoplasms', 'Cataract-associated-Hearing Loss', 'Hearing Loss-associated-Cataract', 'Diabetes Mellitus, Type 2-promote-Alzheimer Disease', 'Proteostasis Deficiencies-contribute-Alzheimer Disease', 'Dementia-shown-Metabolic Diseases', 'Dementia-shown-Hypertension', 'Osteoporosis-lead-Death', 'Wounds and Injuries-compare-Death', 'Death-treated-Pulmonary Disease, Chronic Obstructive', 'Fatigue-quantified-Muscular Dystrophy, Emery-Dreifuss', 'Renal Insufficiency, Chronic-design-Fibrosis', 'Diabetes Mellitus-undergo-Stroke', 'Death-underlie-Hypertension', 'HIV Infections-include-Seizures', 'Liver Failure-categorize-Non-alcoholic Fatty Liver Disease', 'Liver Failure-categorize-Liver Diseases', 'Liver Failure-categorize-Hepatitis C', 'Non-alcoholic Fatty Liver Disease-associated-Death', 'Death-associated-Non-alcoholic Fatty Liver Disease', 'Seizures-improve-HIV Infections', 'Hearing Loss-associated-Leukoencephalopathies', 'Leukoencephalopathies-associated-Hearing Loss', 'Vision Disorders-associated-Cardiac Output, Low', 'Cardiac Output, Low-associated-Vision Disorders', 'Hypertension-associate-Alzheimer Disease', 'Alzheimer Disease-associate-Hypertension', 'Neoplasms-established-Stomach Neoplasms', 'Neoplasms-established-Squamous Cell Carcinoma of Head and Neck', 'Neoplasms-established-Osteosarcoma', 'Breast Neoplasms-proven-Neoplasm Metastasis', 'Cardiovascular Diseases-include-Neoplasms', 'Drug-Related Side Effects and Adverse Reactions-diagnosed-Alzheimer Disease', 'Alzheimer Disease-found-Death', 'Neoplasms-associated-Sleep Wake Disorders', 'Sleep Wake Disorders-associated-Neoplasms', 'Communicable Diseases-lead-Death', 'Heat Stress Disorders-associated-Death', 'Death-associated-Heat Stress Disorders', 'Death-determine-Heat Stress Disorders', 'Duodenal Obstruction-include-Neoplasms', 'Sepsis-assess-Death', 'Cachexia-understand-Cardiovascular Diseases', 'Muscular Atrophy-understand-Cardiovascular Diseases', 'Heart Failure-start-Atrial Fibrillation', 'Heart Failure-start-Coronary Artery Disease', 'Heart Failure-start-Peripheral Arterial Disease', 'Drug-Related Side Effects and Adverse Reactions-provide-Infections', 'Multiple Organ Failure-associated-Infections', 'Infections-associated-Multiple Organ Failure', 'Hearing Loss-assess-Alzheimer Disease', 'Hip Dislocation-prevent-Osteoarthritis', 'Infections-influence-Fractures, Bone', 'Fractures, Bone-influence-Death', 'Death-use-Hodgkin Disease', 'Hodgkin Disease-quantify-Death', 'Lung Diseases, Interstitial-observed-Hodgkin Disease', 'Infections-observed-Hodgkin Disease', 'Hodgkin Disease-experience-Death', 'Hodgkin Disease-experience-Heart Diseases', 'Hodgkin Disease-experience-Lung Diseases, Interstitial', 'Hodgkin Disease-experience-Infections', 'Hodgkin Disease-experience-Neoplasms', 'Neoplasms-characterised-Hematologic Diseases', 'Myelodysplastic Syndromes-characterised-Hematologic Diseases', 'Chronic Disease-report-Hypertension', 'Deglutition Disorders-increase-Pneumonia', 'Chronic Disease-report-Stroke', 'Deglutition Disorders-increase-Parkinson Disease', 'Chronic Disease-report-Diabetes Mellitus', 'Chronic Disease-report-Dementia', 'Tooth Loss-result-Periodontitis', 'Tooth Loss-result-Inflammation', 'Infections-improve-Tuberculosis', 'Giant Cell Arteritis-isolated-Polymyalgia Rheumatica', 'Alzheimer Disease-foreshadow-Neurodegenerative Diseases', 'Hemorrhage-mimic-Neoplasms', 'Anemia-contribute-Chronic Disease', 'Diabetes Mellitus-implicated-Drug-Related Side Effects and Adverse Reactions', 'Neoplasms-increase-Respiratory Distress Syndrome', 'Sarcopenia-refer-Fractures, Bone', 'Muscle Weakness-underlie-Sarcopenia', 'Dementia-show-Creutzfeldt-Jakob Syndrome', 'Osteoporosis-associate-Death', 'Death-associate-Osteoporosis', 'Wounds and Injuries-remain-Brain Injuries, Traumatic', 'Liver Diseases-caused-Hepatitis B', 'Cardiovascular Diseases-related-Renal Insufficiency, Chronic', 'Hepatitis B-combined-Liver Failure', 'Renal Insufficiency, Chronic-characterized-Vascular Remodeling', 'Hepatitis B-combined-Blood Coagulation Disorders', 'Renal Insufficiency, Chronic-characterized-Calcinosis', 'Cardiovascular Diseases-characterized-Vascular Remodeling', 'Cardiovascular Diseases-characterized-Calcinosis', 'Fractures, Bone-attributed-Osteoporosis', 'Cushing Syndrome-increased-Atrial Fibrillation', 'Stroke-defined-Malocclusion', 'Stroke-base-Malocclusion', 'Neoplasms-analyzed-Peritonitis', 'Coinfection-follow-Cerebral Hemorrhage', 'Memory Disorders-improve-Alzheimer Disease', 'Memory Disorders-improve-Parkinson Disease', 'Infections-use-Malocclusion', 'Infections-use-Tuberculosis', 'Prostatic Neoplasms-fail-Death', 'Liver Cirrhosis-associated-Death', 'Death-associated-Liver Cirrhosis', 'Communicable Diseases-claim-Infections', 'Alzheimer Disease-suggested-Drug-Related Side Effects and Adverse Reactions', 'Neurodegenerative Diseases-suggested-Drug-Related Side Effects and Adverse Reactions', 'Heart Arrest-associated-Death', 'Death-associated-Heart Arrest', 'Osteoporosis-identified-Bone Diseases, Metabolic', 'Osteoporosis-identified-Sarcopenia', 'Sarcopenia-found-Osteoporotic Fractures', 'Sarcopenia-found-Osteoporosis', 'Sarcopenia-consider-Osteoporotic Fractures', 'Obesity-associated-Retinal Diseases', 'Retinal Diseases-associated-Obesity', 'Microvascular Angina-defined-Retinal Diseases', 'Obesity, Abdominal-show-Microvascular Angina', 'Microvascular Angina-related-Obesity', 'Obesity-cause-Cardiovascular Diseases', 'Obesity-cause-Microvascular Angina', 'Diabetes Mellitus-cause-Cardiovascular Diseases', 'Diabetes Mellitus-cause-Microvascular Angina', 'Parkinson Disease-cause-Speech Disorders', 'Hemorrhage-increase-Renal Insufficiency, Chronic', 'Neoplasms-linked-Werner Syndrome', 'Werner Syndrome-linked-Breast Neoplasms', 'Werner Syndrome-linked-Sarcoma', 'Diabetes Mellitus-show-Dementia', 'Postoperative Cognitive Complications-involve-Learning Disabilities', 'Inflammation-promote-Postoperative Cognitive Complications', 'Growth Disorders-precipitate-Bone Diseases, Metabolic', 'Growth Disorders-precipitate-Osteoporosis', 'Growth Disorders-increase-Fractures, Bone', 'Bone Diseases, Metabolic-increase-Fractures, Bone', 'Death-shown-Hepatitis C, Chronic', 'Postoperative Cognitive Complications-cause-Brain Damage, Chronic', 'Inflammation-suggest-Alzheimer Disease', 'Guillain-Barre Syndrome-cause-Neoplasm Invasiveness', 'Parkinson Disease-highlight-Neurodegenerative Diseases', 'Osteoporosis-altered-Polycystic Ovary Syndrome', 'Stroke-prevent-Cerebral Hemorrhage', 'Atrophy-take-Alzheimer Disease', 'Leukoencephalopathies-associated-Ischemia', 'Ischemia-associated-Leukoencephalopathies', 'Leukoencephalopathies-associated-Epilepsy', 'Epilepsy-associated-Leukoencephalopathies', 'Leukoencephalopathies-correlated-Atherosclerosis', 'Sleep Initiation and Maintenance Disorders-accelerate-Alzheimer Disease', 'Alzheimer Disease-characterized-Sleep Wake Disorders', 'Sleep Wake Disorders-prevent-Dementia', 'Aneurysm-facilitate-Nervous System Diseases', 'Cardiovascular Diseases-facilitate-Nervous System Diseases', 'Diabetes Mellitus-facilitate-Nervous System Diseases', 'Hypertension-facilitate-Nervous System Diseases', 'Pain-experience-Motor Neuron Disease', 'Arrhythmias, Cardiac-predispose-Death, Sudden', 'Heredodegenerative Disorders, Nervous System-fall-Cardiac Output, Low', 'Hyperalgesia-prevent-Atrial Fibrillation', 'Hyperalgesia-precede-Atrial Fibrillation', 'Infections-become-Death', 'Seizures-vary-Hematoma, Subdural, Chronic', 'Malformations of Cortical Development-include-Seizures', 'Hemorrhage-include-Seizures', 'Retinal Diseases-associated-Heart Failure', 'Heart Failure-associated-Retinal Diseases', 'Osteoarthritis-found-Hip Dislocation, Congenital', 'Communicable Diseases-promote-Immunologic Deficiency Syndromes', 'Hypogonadism-affect-Prostatic Hyperplasia', 'Retinal Degeneration-exhibit-Hearing Loss, Central', 'Retinal Degeneration-exhibit-Vertigo', 'Communicable Diseases-spread-Infections', 'Osteomyelitis-spread-Infections', 'Osteonecrosis-spread-Infections', 'Osteoarthritis-characterized-Joint Diseases', 'Diabetes Mellitus, Type 1-associated-Diabetes Mellitus, Type 2', 'Diabetes Mellitus, Type 2-associated-Diabetes Mellitus, Type 1', 'Sarcopenia-found-Arthritis, Rheumatoid', 'Hypotension, Orthostatic-identify-Death', 'Hypotension, Orthostatic-identify-Cardiovascular Diseases', 'Hypotension, Orthostatic-identify-Heart Failure', 'Hypotension, Orthostatic-identify-Stroke', 'Liver Neoplasms-diagnosed-Neurodegenerative Diseases', 'Wounds and Injuries-affect-Epilepsy', 'Halitosis-favour-Fractures, Open', 'Paralysis-favour-Fractures, Open', 'Obesity, Abdominal-observed-Hypertension', 'Osteoarthritis-relieve-Chronic Disease', 'Colorectal Neoplasms, Hereditary Nonpolyposis-detected-Colonic Neoplasms', 'Diabetes Mellitus-associate-Obesity', 'Obesity-associate-Diabetes Mellitus', 'Diabetes Mellitus-defined-Hypotension', 'Signs and Symptoms, Respiratory-increase-Parkinson Disease', 'Obesity-compared-Death', 'Coronary Artery Disease-remain-Cardiovascular Diseases', 'Neoplasms-distorted-Arbovirus Infections', 'Cardiovascular Diseases-distorted-Arbovirus Infections', 'Neurodegenerative Diseases-play-Multiple Sclerosis', 'Neurodegenerative Diseases-play-Huntington Disease', 'Dementia-play-Neurodegenerative Diseases', 'Dementia-play-Multiple Sclerosis', 'Dementia-play-Huntington Disease', 'Stroke-experience-Death', 'Inflammation-occur-Infections', 'Hemorrhage-characterized-Wounds and Injuries', 'Hemophilia A-lead-Hemorrhage', 'Hemophilia A-lead-Joint Diseases', 'Hemophilia A-lead-Nervous System Diseases', 'Hemophilia A-lead-Death', 'Dementia-experience-Urinary Incontinence', 'HIV Infections-contribute-Hypertension', 'HIV Infections-contribute-Inflammation', 'Headache Disorders, Secondary-considered-Sleep Initiation and Maintenance Disorders', 'Hypertension-contribute-Inflammation', 'Sarcopenia-define-Muscular Diseases', 'Sarcopenia-use-Muscular Diseases', 'Sarcopenia-diagnosed-Oculocerebrorenal Syndrome', 'Sarcopenia-use-Oculocerebrorenal Syndrome', 'Acidosis-seen-Kidney Diseases', 'Death-associated-Tachycardia', 'Tachycardia-associated-Death', 'Renal Insufficiency, Chronic-control-Headache Disorders, Secondary', 'Headache Disorders, Secondary-provide-Kidney Diseases', 'Dementia-affected-Alzheimer Disease', 'Esophageal Neoplasms-find-Obesity', 'Death-receive-Pneumonia', 'Vision Disorders-induced-Diabetes Mellitus', 'Diabetes Mellitus-caused-Communicable Diseases', 'Diabetes Mellitus-observe-Vision Disorders', 'Sleep Wake Disorders-include-Parkinson Disease', 'Thrombosis-remain-Death', 'Thrombosis-remain-Neoplasms', 'Thrombosis-remain-Neoplasm Metastasis', 'Death-observed-Infections', 'Stroke-reduce-Diabetes Mellitus', 'Equinus Deformity-carry-Diabetes Mellitus', 'Equinus Deformity-carry-Foot Ulcer', 'Ulcer-reduce-Foot Ulcer', 'Nervous System Diseases-develop-Pain', 'Leukemia, Lymphoid-related-Neoplasms', 'Sarcopenia-vary-Lung Diseases', 'Inflammation-associated-Rheumatic Diseases', 'Rheumatic Diseases-associated-Inflammation', 'Inflammation-manifest-Infections', 'Infections-protected-Coronavirus Infections', 'Cerebral Hemorrhage-defined-Death', 'Neurodegenerative Diseases-defined-Death', 'Glaucoma, Open-Angle-caused-Ocular Hypertension', 'Ocular Hypertension-lead-Glaucoma, Open-Angle', 'Sleep Apnea, Obstructive-include-Alzheimer Disease', 'Ovarian Neoplasms-coincide-Infertility', 'Alzheimer Disease-appear-Dysbiosis', 'Communicable Diseases-considered-Cartilage Diseases', 'Neoplasms-evaluate-Colorectal Neoplasms', 'Metabolic Syndrome-prevent-Diabetes Mellitus', 'Infections-consider-Death', 'Heart Diseases-associated-Malnutrition', 'Malnutrition-associated-Heart Diseases', 'Salter-Harris Fractures-caused-Wounds and Injuries', 'Coronary Artery Disease-induce-Heart Failure, Diastolic', 'Inflammation-lead-Respiratory Distress Syndrome', 'Inflammation-lead-Respiratory Tract Diseases', 'Inflammation-prevent-Respiratory Insufficiency', 'Muscular Diseases-mark-Deglutition Disorders', 'Sleep Apnea Syndromes-infect-Infections', 'Colonic Polyps-related-Acromegaly', 'Thyroid Neoplasms-related-Acromegaly', 'Hypertension-related-Acromegaly', 'Bone Diseases-related-Acromegaly', 'Dementia-assess-Death', 'Edema-occur-Hypertension', 'Constipation-address-Inflammatory Bowel Diseases', 'Fecal Incontinence-address-Inflammatory Bowel Diseases', 'Peripheral Arterial Disease-associated-Muscular Diseases', 'Muscular Diseases-associated-Peripheral Arterial Disease', 'Atherosclerosis-associated-Muscular Diseases', 'Muscular Diseases-associated-Atherosclerosis', 'Hypertension-preexist-Kidney Diseases', 'Diabetes Mellitus-preexist-Kidney Diseases', 'Infections-experience-Respiratory Tract Diseases', 'Phenylketonurias-repair-Skin Diseases', 'Glycogen Storage Disease Type II-lead-Death', 'Glycogen Storage Disease Type II-lead-Retinal Diseases', 'Mitochondrial Diseases-play-Neurodegenerative Diseases', 'Meningitis, Aseptic-develop-Varicella Zoster Virus Infection', 'Hypotension-elucidate-Obesity', 'Fractures, Bone-lead-Pain', 'Death-found-Stroke', 'Death-appear-Polymyalgia Rheumatica', 'Death-found-Ischemia', 'Stroke-appear-Polymyalgia Rheumatica', 'Ischemic Attack, Transient-involve-Cranial Nerve Diseases', 'Cerebral Infarction-involve-Cranial Nerve Diseases', 'Polymyalgia Rheumatica-confer-Ischemia', 'Ischemia-exhibit-Death', 'Cardiovascular Diseases-reduce-Seizures', 'Hypertension-face-Paralysis', 'Cardiovascular Diseases-enhance-Seizures', 'Inflammation-define-Kidney Diseases', 'Diurnal Enuresis-linked-Muscle Weakness', 'Death-show-Fractures, Bone', 'Death-followed-Fractures, Bone', 'Fractures, Bone-show-Death', 'Abducens Nerve Diseases-increase-Esotropia', 'Neurodegenerative Diseases-defined-Stroke', 'Infections-increase-Obesity', 'Neuromuscular Diseases-associated-Inflammation', 'Inflammation-associated-Neuromuscular Diseases', 'Peripheral Arterial Disease-evaluate-Albuminuria', 'Heart Failure-follow-Death, Sudden, Cardiac', 'Communicable Diseases-accounted-Death', 'Communicable Diseases-accounted-Heart Failure', 'Gaucher Disease-favour-Fatty Liver', 'Fatty Liver-determine-Liver Cirrhosis', 'Fatty Liver-determine-Gaucher Disease', 'Metabolic Syndrome-reduce-Vision Disorders', 'Postpartum Hemorrhage-optimise-Anemia', 'Acute Disease-involve-Osteoarthritis', 'Anemia-minimise-Postpartum Hemorrhage', 'Diarrhea-present-Signs and Symptoms, Respiratory', 'Signs and Symptoms, Digestive-include-Diarrhea', 'Signs and Symptoms, Digestive-include-Nausea', 'Signs and Symptoms, Digestive-include-Vomiting', 'Diarrhea-related-Drug-Related Side Effects and Adverse Reactions', 'Diarrhea-thought-Drug-Related Side Effects and Adverse Reactions', 'Lupus Erythematosus, Systemic-followed-Retinal Diseases', 'Heart Diseases-found-Tachycardia', 'Infections-compared-Inflammatory Bowel Diseases', 'Necrosis-associated-Crohn Disease', 'Crohn Disease-associated-Necrosis', 'Necrosis-associated-Colitis, Ulcerative', 'Colitis, Ulcerative-associated-Necrosis', 'Cardiovascular Diseases-associated-Hypotension, Orthostatic', 'Hypotension, Orthostatic-associated-Cardiovascular Diseases', 'Rotavirus Infections-include-Gastroenteritis', 'Dementia-revert-Alzheimer Disease', 'Skin Diseases-include-Chronic Disease', 'Aneurysm-considered-Stroke', 'Death-related-Heart Diseases', 'Death-result-Heart Diseases', 'Death-characterize-Heart Diseases', 'Heart Diseases-persist-Death', 'Diabetes Mellitus-remain-Death', 'Inflammation-play-Metabolic Diseases', 'Inflammation-play-Obesity', 'Immune System Diseases-affect-Diabetes Mellitus, Type 2', 'Immune System Diseases-affect-Diabetes Mellitus', 'Immune System Diseases-explore-Communicable Diseases', 'Diabetes Mellitus, Type 2-become-Communicable Diseases', 'Diabetes Mellitus-become-Communicable Diseases', 'Respiratory Tract Infections-related-Respiratory Tract Diseases', 'Ulcer-reveal-Carcinoma, Basal Cell', 'Ulcer-reveal-Carcinoma, Squamous Cell', 'Sepsis-result-Death', 'Renal Insufficiency, Chronic-continue-Diabetes Mellitus', 'Dysbiosis-cause-Inflammation', 'Dysbiosis-cause-Death', 'Death-increase-Mitral Valve Insufficiency', 'Mitral Valve Insufficiency-classified-Rheumatic Diseases', 'Mitral Valve Insufficiency-classified-Endocarditis', 'Osteoarthritis-include-Chronic Disease', 'Inflammation-remain-Substance-Related Disorders', 'Multiple Sclerosis-target-Mitochondrial Diseases', 'Mitochondrial Diseases-inhibit-Multiple Sclerosis', 'Malnutrition-live-Dementia', 'Shoulder Dislocation-review-Bankart Lesions', 'Shoulder Dislocation-review-Fractures, Bone', 'Shoulder Dislocation-review-Muscular Atrophy', 'Fractures, Bone-occur-Bankart Lesions', 'Mandibular Nerve Injuries-occur-Bankart Lesions', 'Osteoporosis-experience-Femoral Fractures', 'Calcinosis-known-Aortic Valve Stenosis', 'Acute Disease-associated-Death', 'Death-associated-Acute Disease', 'Hyperkinesis-combate-Heredodegenerative Disorders, Nervous System', 'Alzheimer Disease-implicate-Inflammation', 'Parkinson Disease-implicate-Inflammation', 'Memory Disorders-operationalise-Alzheimer Disease', 'Malnutrition-sustain-Delirium', 'Hearing Loss-sustain-Delirium', 'Respiratory Insufficiency-associated-Pneumonia', 'Pneumonia-associated-Respiratory Insufficiency', 'Pneumothorax-associated-Pneumonia', 'Pneumonia-associated-Pneumothorax', 'Pneumothorax-related-Pneumonia', 'Vision Disorders-include-Vision, Low', 'Vision Disorders-include-Blindness', 'Heart Diseases-associated-Dementia', 'Dementia-associated-Heart Diseases', 'Infections-exhibit-Death', 'Cardiovascular Diseases-follow-Diabetes Mellitus', 'Brain Injuries, Traumatic-remain-Blood Coagulation Disorders', 'Cerebral Infarction-become-Stroke', 'Sarcopenia-associated-Myotonic Dystrophy', 'Myotonic Dystrophy-associated-Sarcopenia', 'Parkinson Disease-calculated-Parkinson Disease, Secondary', 'Aneurysm-include-Blindness', 'Constriction, Pathologic-include-Blindness', 'Polymyalgia Rheumatica-lead-Inflammation', 'Myelodysplastic Syndromes-ameliorate-Anemia', 'Infections-include-Ulcer', 'Placenta Diseases-lead-Death', 'Dementia-include-Diffuse Neurofibrillary Tangles with Calcification', 'Dementia-include-Infarction', 'Dementia-Establish-Infarction', 'Hearing Loss-hear-Death', 'Hearing Loss-associated-Plaque, Amyloid', 'Plaque, Amyloid-associated-Hearing Loss', 'Brenner Tumor-determined-Abdominal Pain', 'Brenner Tumor-manifested-Abdominal Pain', 'Abdominal Pain-combine-Metrorrhagia', 'Brenner Tumor-manifested-Alcoholic Intoxication', 'Brenner Tumor-manifested-Intestinal Atresia', 'Abdominal Pain-combine-Alcoholic Intoxication', 'Abdominal Pain-combine-Intestinal Atresia', 'Gait Disorders, Neurologic-accompanied-Nerve Degeneration', 'Parkinson Disease-show-Neurodegenerative Diseases', 'Parkinson Disease-show-Muscle Rigidity', 'Parkinson Disease-show-Tremor', 'Parkinson Disease-show-Hypokinesia', 'Parkinson Disease-observed-Parkinson Disease, Secondary', 'Diabetes Mellitus-linked-Nervous System Diseases', 'Shock, Septic-suffer-Sepsis', 'Neoplasms-suffer-Sepsis', 'Shock-suffer-Sepsis', 'Sepsis-diagnosed-Death', 'Neoplasms-range-Sepsis', 'Neoplasms-range-Shock, Septic', 'Infections-range-Sepsis', 'Infections-range-Shock, Septic', 'Sepsis-range-Shock, Septic', 'Adrenal Insufficiency-confer-Dyskinesia, Drug-Induced', 'Adrenal Insufficiency-confer-Parkinsonian Disorders', 'Atrial Fibrillation-reduce-Hemorrhage', 'Coronary Artery Disease-reduce-Hemorrhage', 'Hemorrhage-related-Atrial Fibrillation', 'Pain-associated-Rib Fractures', 'Rib Fractures-associated-Pain', 'Pain-include-Death', 'Pain-include-Pneumonia', 'Thyroiditis, Autoimmune-coexist-Diabetes Mellitus', 'Thyroiditis, Autoimmune-deteriorated-Diabetes Mellitus', 'Pulmonary Disease, Chronic Obstructive-contributor-Death', 'Hypertension-increase-Obesity', 'Renal Insufficiency, Chronic-increase-Obesity', 'Hemorrhage-result-Death', 'Cataract-used-Vision Disorders', 'Cataract-address-Vision Disorders', 'Polycystic Ovary Syndrome-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-Polycystic Ovary Syndrome', 'Polycystic Ovary Syndrome-associated-Sleep Apnea, Obstructive', 'Sleep Apnea, Obstructive-associated-Polycystic Ovary Syndrome', 'Polycystic Ovary Syndrome-associated-Endometrial Neoplasms', 'Endometrial Neoplasms-associated-Polycystic Ovary Syndrome', 'Fever-follow-Cough', 'Brain Injuries, Traumatic-reflect-Alzheimer Disease', 'Brain Injuries, Traumatic-increase-Alzheimer Disease', 'Brain Injuries, Traumatic-reflect-Neurodegenerative Diseases', 'Rhinitis, Allergic-obtained-Drug Hypersensitivity', 'Rhinitis, Allergic-improve-Signs and Symptoms, Respiratory', 'Rhinitis, Allergic-improve-Nasal Obstruction', 'Cardiovascular Diseases-observed-Hypertension', 'Skin Neoplasms-used-Neoplasms', 'Metabolic Diseases-increase-Dementia', 'Metabolic Diseases-increase-Alzheimer Disease', 'Parkinson Disease, Secondary-include-Movement Disorders', 'Arthritis-include-Movement Disorders', 'Hernia-identify-Death', 'Death-burdened-Hernia', 'Cardiovascular Diseases-improve-Heart Arrest', 'Cardiovascular Diseases-reduce-Neoplasms', 'Mitochondrial Diseases-promote-Inflammation', 'Cardiovascular Diseases-contribute-Atherosclerosis', 'Mitochondrial Diseases-contribute-Plaque, Atherosclerotic', 'Inflammation-contribute-Plaque, Atherosclerotic', 'Renal Insufficiency-result-Death', 'Sarcopenia-associate-Multiple Myeloma', 'Multiple Myeloma-associate-Sarcopenia', 'Sarcopenia-associate-Cardiovascular Diseases', 'Cardiovascular Diseases-associate-Sarcopenia', 'Sarcopenia-associated-Multiple Myeloma', 'Multiple Myeloma-associated-Sarcopenia', 'Anophthalmos-associated-Parkinson Disease', 'Parkinson Disease-associated-Anophthalmos', 'Hypertension-associated-Parkinson Disease', 'Parkinson Disease-associated-Hypertension', 'Refractive Errors-associated-Parkinson Disease', 'Parkinson Disease-associated-Refractive Errors', 'Ischemia-associated-Atrial Fibrillation', 'Atrial Fibrillation-associated-Ischemia', 'Progeria-include-Genetic Diseases, Inborn', 'Growth Disorders-recapitulate-Progeria', 'Growth Disorders-include-Progeria', 'Aneurysm-recapitulate-Progeria', 'Aneurysm-include-Progeria', 'Legionellosis-accompany-Pneumonia', 'Legionellosis-characterized-Pneumonia', 'Bacterial Infections-characterized-Pneumonia', 'Bacterial Infections-characterized-Infections', 'Infections-characterized-Pneumonia', 'Thrombosis-balance-Hemorrhage', 'Thrombosis-balance-Intracranial Hemorrhages', 'Heart Failure-recognized-Death', 'Neurodegenerative Diseases-include-Brain Diseases', 'Neoplasms-include-Brain Diseases', 'Postpartum Hemorrhage-appear-Ecchymosis', 'Parkinson Disease, Secondary-based-Parkinson Disease', 'Parkinson Disease-account-Parkinson Disease, Secondary', 'Parkinson Disease-account-Atherosclerosis', 'Parkinson Disease-account-Arteriolosclerosis', 'Parkinson Disease, Secondary-account-Atherosclerosis', 'Primary Ovarian Insufficiency-lead-Infertility', 'Inflammation-share-Atherosclerosis', 'Inflammation-mediate-Neurodegenerative Diseases', 'Stroke-share-Atherosclerosis', 'Stroke-mediate-Neurodegenerative Diseases', 'Atherosclerosis-mediate-Neurodegenerative Diseases', 'Neurodegenerative Diseases-mediate-Muscular Dystrophies', 'Fasciculation-known-Sarcopenia', 'Kidney Failure, Chronic-associated-Death', 'Death-associated-Kidney Failure, Chronic', 'Diabetes Mellitus, Type 2-characterized-Fractures, Bone', 'Diabetes Mellitus, Type 2-characterized-Muscular Dystrophy, Duchenne', 'Fractures, Bone-characterized-Muscular Dystrophy, Duchenne', 'Muscular Dystrophy, Duchenne-underestimate-Diabetes Mellitus, Type 2', 'Glomerulosclerosis, Focal Segmental-increased-Fractures, Bone', 'Glomerulosclerosis, Focal Segmental-increased-Xanthomatosis, Cerebrotendinous', 'Prediabetic State-increased-Fractures, Bone', 'Fractures, Bone-increased-Xanthomatosis, Cerebrotendinous', 'Ovarian Diseases-cause-Infertility, Female', 'Primary Ovarian Insufficiency-defined-Ovarian Diseases', 'Death-related-Aneurysm', 'Hypertension-co-existing-Diabetes Mellitus', 'Diabetes Mellitus-co-existing-Death', 'Chronic Traumatic Encephalopathy-confirm-Neurodegenerative Diseases', 'Neurodegenerative Diseases-confirm-Nervous System Diseases', 'Neurodegenerative Diseases-publish-Stroke', 'Tauopathies-associated-Craniocerebral Trauma', 'Craniocerebral Trauma-associated-Tauopathies', 'Neurodegenerative Diseases-diagnosed-Chronic Traumatic Encephalopathy', 'Craniocerebral Trauma-judge-Chronic Traumatic Encephalopathy', 'Multiple Sclerosis-characterized-Nerve Degeneration', 'Heredodegenerative Disorders, Nervous System-characterized-Demyelinating Diseases', 'Heredodegenerative Disorders, Nervous System-characterized-Nerve Degeneration', 'Myotonic Dystrophy-associated-Vascular Calcification', 'Vascular Calcification-associated-Myotonic Dystrophy', 'Fatigue-target-Renal Insufficiency, Chronic', 'Pulmonary Disease, Chronic Obstructive-confer-Death', 'Thromboembolism-defined-Cerebral Infarction', 'Arbovirus Infections-associated-Infections', 'Infections-associated-Arbovirus Infections', 'Ocular Hypertension-defined-Glaucoma', 'Glaucoma-compare-Eye Abnormalities', 'Pain-base-Chronic Pain', 'Cardiomyopathies-characterized-Hypotension', 'Cardiomyopathies-characterized-Cardiomyopathy, Hypertrophic', 'Hypotension-characterized-Cardiomyopathy, Hypertrophic', 'Breast Neoplasms-diagnosed-Rectal Neoplasms', 'Prostatic Neoplasms-diagnosed-Rectal Neoplasms', 'Hypertension, Pulmonary-exposed-Hyperoxia', 'Diabetes Mellitus-share-Obesity', 'Diabetes Mellitus-cause-Neoplasms', 'Neurodegenerative Diseases-represent-Death', 'Death-occur-Constriction, Pathologic', 'Infections-compare-Death', 'Infections-come-Death', 'Infections-acquire-Death', 'Dementia-remain-Alzheimer Disease', 'Cerebrovascular Disorders-include-Alzheimer Disease', 'Movement Disorders-increase-Scoliosis', 'Inflammation-play-HIV Infections', 'Seizures-evolve-Epilepsy', 'Prostatitis-play-Prostatic Hyperplasia', 'Alcoholism-associated-Sarcopenia', 'Sarcopenia-associated-Alcoholism', 'Obesity, Abdominal-increase-Colorectal Neoplasms', 'Obesity, Abdominal-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-Obesity, Abdominal', 'Obesity, Abdominal-show-Cardiovascular Diseases', 'HIV Infections-increase-AIDS Arteritis, Central Nervous System', 'Hearing Loss-reflect-Ear Diseases', 'Eye Injuries-include-Rupture', 'Eye Injuries-include-Headache', 'Eye Injuries-include-Retinal Detachment', 'Eye Injuries-include-Optic Nerve Injuries', 'Rupture-operated-Eye Injuries', 'Eye Injuries-associated-Death', 'Death-associated-Eye Injuries', 'Wounds and Injuries-identify-Eye Injuries', 'Osteochondritis-suffer-Pain', 'Infections-increase-Hypertension', 'Asthma-Chronic Obstructive Pulmonary Disease Overlap Syndrome-lead-Airway Obstruction', 'Vascular Calcification-outweigh-Calcinosis', 'Vascular Calcification-outweigh-Death', 'Calcinosis-outweigh-Death', 'Vascular Calcification-defined-Aortic Arch Syndromes', 'Aortic Arch Syndromes-associated-Death', 'Death-associated-Aortic Arch Syndromes', 'Osteoporosis-associated-Dementia', 'Dementia-associated-Osteoporosis', 'Communicable Diseases-defined-Coronary Artery Disease', 'Communicable Diseases-defined-Stroke', 'Chronic Disease-live-HIV Infections', 'Sarcopenia-associated-Fractures, Multiple', 'Fractures, Multiple-associated-Sarcopenia', 'Death-share-Rheumatic Diseases', 'Giant Cell Arteritis-share-Rheumatic Diseases', 'Polymyalgia Rheumatica-share-Rheumatic Diseases', 'Hypertension-followed-Cardiovascular Diseases', 'Leukoencephalopathies-observed-Alzheimer Disease', 'Alzheimer Disease-represent-Leukoencephalopathies', 'Inflammation-accelerate-Neoplasms', 'Inflammation-exacerbated-Neoplasms', 'Inflammation-consider-Neoplasms', 'Movement Disorders-exhibit-Neurodegenerative Diseases', 'Neurodegenerative Diseases-characterized-Movement Disorders', 'Fractures, Bone-accompanied-Neurologic Manifestations', 'Osteoporosis-include-Acquired Immunodeficiency Syndrome', 'Deglutition Disorders-cause-Malnutrition', 'Hypertrophy-require-Cardiovascular Diseases', 'Hypertrophy-make-Chronic Disease', 'Parkinson Disease-associated-Pneumonia, Aspiration', 'Pneumonia, Aspiration-associated-Parkinson Disease', 'Parkinson Disease-choke-Pneumonia, Aspiration', 'Parkinson Disease-associated-Neuroleptic Malignant Syndrome', 'Neuroleptic Malignant Syndrome-associated-Parkinson Disease', 'Parkinson Disease-choke-Neuroleptic Malignant Syndrome', 'Pneumonia, Aspiration-choke-Neuroleptic Malignant Syndrome', 'Bone Neoplasms-associated-Mitochondrial Diseases', 'Mitochondrial Diseases-associated-Bone Neoplasms', 'Bone Neoplasms-associated-Bone Resorption', 'Bone Resorption-associated-Bone Neoplasms', 'Renal Insufficiency, Chronic-include-Diabetes Mellitus', 'Constipation-associated-Colonic Polyps', 'Colonic Polyps-associated-Constipation', 'Cataract-found-Blindness', 'Hyperoxia-increase-Hypoxia', 'Osteoporosis-attributed-Bone Neoplasms', 'Vascular System Injuries-investigated-Atrophy', 'Osteoporosis-attributed-Bone Resorption', 'Kidney Failure, Chronic-characterized-Death', 'Respiratory Distress Syndrome-stimulate-Aneurysm', 'Death-experience-Fractures, Bone', 'Neurodegenerative Diseases-include-Heredodegenerative Disorders, Nervous System', 'Death-remain-Cardiovascular Diseases', 'Diabetes Mellitus-affect-Obesity', 'Xerostomia-investigate-Periodontitis', 'Nerve Degeneration-stem-Neurotoxicity Syndromes', 'Alzheimer Disease-link-Nervous System Diseases', 'Alzheimer Disease-remain-Nervous System Diseases', 'Death-assess-Alzheimer Disease', 'Vision Disorders-associated-Renal Insufficiency', 'Renal Insufficiency-associated-Vision Disorders', 'Leishmaniasis, Cutaneous-mistaken-Osteoporotic Fractures', 'Brain Injuries, Traumatic-follow-Multiple Organ Failure', 'Death-follow-Multiple Organ Failure', 'Heart Diseases-offer-Death, Sudden', 'Leukemia, Lymphocytic, Chronic, B-Cell-characterized-Immunologic Deficiency Syndromes', 'Death-cause-Colorectal Neoplasms', 'Death-predict-Chronic Disease', 'Cartilage Diseases-ameliorate-Osteoarthritis', 'Osteoarthritis-characterize-Cartilage Diseases', 'Osteoarthritis-characterize-Inflammation', 'Bone Diseases, Metabolic-compromise-Fractures, Bone', 'Death-represent-Lung Neoplasms', 'Neurodegenerative Diseases-characterize-Cartilage Diseases', 'Death-represent-Pulmonary Disease, Chronic Obstructive', 'Death-represent-Coronary Artery Disease', 'Neurodegenerative Diseases-characterize-Inflammation', 'Death-represent-Stroke', 'Alzheimer Disease-belong-Neurodegenerative Diseases', 'Parkinson Disease-belong-Neurodegenerative Diseases', 'Amyotrophic Lateral Sclerosis-belong-Neurodegenerative Diseases', 'Fatty Liver-measured-Fibrosis', 'Dementia-belong-Neurodegenerative Diseases', 'Huntington Disease-belong-Neurodegenerative Diseases', 'Tuberculosis-used-Infections', 'Tuberculosis-reduce-Death', 'Inflammation-compare-Pneumonia', 'Inflammation-show-Pneumonia', 'Death-treated-Ischemia', 'Osteoporosis-prevent-Heart Diseases', 'Primary Ovarian Insufficiency-include-Infertility, Female', 'Azoospermia-include-Infertility, Female', 'Vision Disorders-defined-Blindness', 'Cerebral Hemorrhage-underlie-Hypertension', 'Cerebral Hemorrhage-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-Cerebral Hemorrhage', 'Cerebral Hemorrhage-underlie-Diabetes Mellitus', 'Pulmonary Disease, Chronic Obstructive-associate-Death', 'Death-associate-Pulmonary Disease, Chronic Obstructive', 'Pulmonary Disease, Chronic Obstructive-demand-Death', 'Thrombophilia-result-Thromboembolism', 'Dementia-considered-Alzheimer Disease', 'Dementia-characterized-Alzheimer Disease', 'Dementia-prevent-Hypertension', 'Breast Neoplasms-constitute-Neoplasms', 'Diabetes Mellitus-show-Ataxia', 'Alzheimer Disease-considered-Nervous System Diseases', 'Fractures, Bone-obtained-Hypotension', 'Hypertension-pressure-Heart Diseases', 'Diabetes Mellitus, Type 1-used-Hypoglycemia', 'Diabetes Mellitus, Type 1-disrupted-Hypoglycemia', 'Diabetes Mellitus, Type 1-used-Hyperglycemia', 'Diabetes Mellitus, Type 1-disrupted-Hyperglycemia', 'Inflammation-lead-Heart Failure, Diastolic', 'Gout-stabilize-Renal Insufficiency, Chronic', 'Alzheimer Disease-traced-Sleep Initiation and Maintenance Disorders', 'Fatigue-facilitate-Anemia', 'Fatigue-associated-Anemia', 'Anemia-associated-Fatigue', 'Metabolic Diseases-include-Metabolic Syndrome', 'Metabolic Diseases-interrelated-Metabolic Syndrome', 'Xerostomia-associated-Pain', 'Pain-associated-Xerostomia', 'Osteoporosis-exposed-Periodontitis', 'Sarcopenia-evaluated-Hypotension, Orthostatic', 'Kyphosis-associated-Cardiac Output, Low', 'Cardiac Output, Low-associated-Kyphosis', 'Osteoporotic Fractures-study-Kyphosis', 'Osteoporotic Fractures-defined-Kyphosis', 'Kyphosis-result-Fractures, Bone', 'Kyphosis-play-Intervertebral Disc Degeneration', 'Fractures, Bone-play-Intervertebral Disc Degeneration', 'Fractures, Bone-play-Kyphosis', 'Intervertebral Disc Degeneration-play-Kyphosis', 'Respiratory Tract Infections-underlie-Heart Diseases', 'Obesity-associate-Immunologic Deficiency Syndromes', 'Immunologic Deficiency Syndromes-associate-Obesity', 'Immunologic Deficiency Syndromes-linked-Respiratory Tract Diseases', 'Diabetes Mellitus-associate-Immunologic Deficiency Syndromes', 'Immunologic Deficiency Syndromes-associate-Diabetes Mellitus', 'Hypertension-associate-Immunologic Deficiency Syndromes', 'Immunologic Deficiency Syndromes-associate-Hypertension', 'Chronic Disease-develop-Infections', 'Diabetes Mellitus, Type 2-associated-Myocardial Infarction', 'Myocardial Infarction-associated-Diabetes Mellitus, Type 2', 'Diabetes Mellitus, Type 2-matched-Diabetes Mellitus', 'Diabetes Mellitus, Type 2-associated-Heart Failure', 'Heart Failure-associated-Diabetes Mellitus, Type 2', 'Cardiovascular Diseases-identify-Osteoarthritis', 'Cardiovascular Diseases-identify-Hypothyroidism', 'Cardiovascular Diseases-identify-Diabetes Mellitus, Type 2', 'Osteoarthritis-identify-Diabetes Mellitus, Type 2', 'Hypothyroidism-identify-Diabetes Mellitus, Type 2', 'Hypertension-followed-Pulmonary Disease, Chronic Obstructive', 'Death-include-Ulcer', 'Arteriosclerosis-defined-Atherosclerosis', 'Neurologic Manifestations-promote-Neoplasms', 'Hip Fractures-fall-Obesity', 'Atrophy-accelerated-Muscle Weakness', 'Neoplasms-result-Cardiovascular Diseases', 'Cardiovascular Diseases-constitute-Death', 'Cardiovascular Diseases-constitute-Neoplasms', 'Diverticulosis, Colonic-identify-Signs and Symptoms, Digestive', 'Osteoporosis-divide-Fractures, Bone', 'Death-found-Myocardial Infarction', 'Alzheimer Disease-follow-Infections', 'Sclerosis-include-Heredodegenerative Disorders, Nervous System', 'Epstein-Barr Virus Infections-defined-Leukemia, Large Granular Lymphocytic', 'Progeria-caused-Cardiovascular Diseases', 'Genetic Diseases, Inborn-caused-Cardiovascular Diseases', 'Lung Diseases-succumb-Death', 'Inflammation-persist-Takotsubo Cardiomyopathy', 'Diabetes Mellitus-predispose-Cardio-Renal Syndrome', 'Diabetes Mellitus, Type 2-contribute-Inflammation', 'Chronic Disease-consider-Inflammation', 'Inflammation-develop-Alzheimer Disease', 'Delirium-develop-Alzheimer Disease', 'Myotonic Dystrophy-determined-Breast Neoplasms', 'Breast Neoplasms-associated-Myotonic Dystrophy', 'Myotonic Dystrophy-associated-Breast Neoplasms', 'Spinal Cord Injuries-observed-Wounds and Injuries', 'Malnutrition-show-Death', 'Obesity-result-Headache Disorders, Primary', 'Alzheimer Disease-ensure-Dementia', 'Alzheimer Disease-involve-Hypoxia', 'Respiratory Tract Infections-considered-Communicable Diseases', 'Infections-infect-Death', 'Respiratory Distress Syndrome-lead-Disseminated Intravascular Coagulation', 'Respiratory Distress Syndrome-represent-Infections', 'Thromboembolism-represent-Antiphospholipid Syndrome', 'Thromboembolism-lead-Disseminated Intravascular Coagulation', 'Disseminated Intravascular Coagulation-represent-Antiphospholipid Syndrome', 'Disseminated Intravascular Coagulation-represent-Infections', 'Abnormalities, Drug-Induced-linked-Inflammation', 'Myasthenia Gravis-lead-Muscle Weakness', 'Autoimmune Diseases-result-Muscle Weakness', 'Autoimmune Diseases-lead-Muscle Weakness', 'Death-become-Diabetes Mellitus', 'Death-improve-Diabetes Mellitus', 'Mastocytosis, Systemic-increase-Infections', 'Mastocytosis, Systemic-result-Cardiovascular Diseases', 'Mastocytosis, Systemic-result-Neoplasms', 'Mastocytosis, Systemic-result-Inflammation', 'Infections-exacerbate-Inflammation', 'Amyotrophic Lateral Sclerosis-associated-Motor Neuron Disease', 'Motor Neuron Disease-associated-Amyotrophic Lateral Sclerosis', 'Neurodegenerative Diseases-associated-Motor Neuron Disease', 'Motor Neuron Disease-associated-Neurodegenerative Diseases', 'Diabetes Mellitus-followed-Ulcer', 'Diabetes Mellitus-followed-Wounds and Injuries', 'Neoplasms-protect-Infections', 'Macular Degeneration-categorized-Myopia, Degenerative', 'Macular Degeneration-base-Myopia, Degenerative', 'Headache-include-Fibromyalgia', 'Migraine Disorders-include-Fibromyalgia', 'Headache Disorders, Secondary-include-Fibromyalgia', 'Headache Disorders, Secondary-include-Headache', 'Deglutition Disorders-cause-Pneumonia, Aspiration', 'Atrophy-include-Voice Disorders', 'Paralysis-include-Voice Disorders', 'Labyrinth Diseases-found-Otitis', 'Dysphonia-include-Voice Disorders', 'Polyps-include-Voice Disorders', 'Paralysis-include-Dysphonia', 'Paralysis-include-Polyps', 'Dysphonia-include-Polyps', 'Heart Arrest-play-Neoplasms', 'Sarcopenia-combined-Critical Illness', 'Leukoencephalopathies-implicated-Neurodegenerative Diseases', 'Death-arise-Infections', 'Obesity, Abdominal-assess-Dementia', 'Dementia-compare-Obesity', 'Metabolic Syndrome-type-Diabetes Mellitus', 'Metabolic Syndrome-type-Cardiovascular Diseases', 'Hypertension-type-Cardiovascular Diseases', 'Acute Kidney Injury-develop-Fibrosis', 'Mitochondrial Diseases-activate-Inflammation', 'Acute Kidney Injury-use-Acute Disease', 'Acute Kidney Injury-characterize-Acute Disease', 'Hypertriglyceridemia-emerge-Vascular Calcification', 'Diabetic Foot-classified-Ischemia', 'Neoplasms-identified-Cardiovascular Diseases', 'Sarcopenia-represent-Kidney Diseases', 'Sarcopenia-defined-Neoplasms', 'Renal Insufficiency, Chronic-develop-Hemolytic-Uremic Syndrome', 'Sarcopenia-defined-Heart Failure', 'Stroke-experienced-Pain', 'Stroke-experienced-Weight Loss', 'Stroke-make-Death', 'Cardiovascular Diseases-mediate-Osteoporosis', 'Osteoarthritis-mediate-Osteoporosis', 'Pulmonary Fibrosis-mediate-Osteoporosis', 'Kidney Diseases-mediate-Osteoporosis', 'Neurodegenerative Diseases-mediate-Osteoporosis', 'Fatty Liver-mediate-Osteoporosis', 'Metabolic Diseases-mediate-Osteoporosis', 'Dementia-applied-Stroke', 'Dementia-predict-Stroke', 'Neoplasms-work-Hemophilia A', 'Alzheimer Disease-associated-Amyloidosis', 'Amyloidosis-associated-Alzheimer Disease', 'Zoonoses-cause-Wounds and Injuries', 'Death-diagnosed-Neoplasms', 'Diabetes Mellitus, Type 2-characterized-Metabolic Diseases', 'Prostatic Hyperplasia-characterized-Metabolic Diseases', 'Neoplasms-demonstrate-Carcinoma, Hepatocellular', 'Death-pay-Infections', 'Vision Disorders-caused-Cataract', 'Movement Disorders-observed-Anophthalmos', 'Melanoma-generated-Neoplasms', 'Inflammation-treat-Melanoma', 'Cytomegalovirus Infections-consider-Anemia, Hemolytic', 'Cytomegalovirus Infections-admitted-Musculoskeletal Diseases', 'Anemia, Hemolytic-admitted-Musculoskeletal Diseases', 'Osteoporosis-result-Death', 'Cytomegalovirus Infections-result-Multiple Trauma', 'Anemia, Hemolytic, Autoimmune-result-Multiple Trauma', 'Severe Acute Respiratory Syndrome-develop-Chemical and Drug Induced Liver Injury', 'Neoplasms-arise-Arachnoiditis', 'Hypertension-correlated-Diabetes Mellitus', 'Obesity-correlated-Diabetes Mellitus', 'Obesity, Abdominal-correlated-Diabetes Mellitus', 'Bacterial Infections-continue-Death', 'Benign Paroxysmal Positional Vertigo-follow-Meniere Disease', 'Neoplasms-achieved-Glioblastoma', 'Fractures, Bone-fall-Hip Fractures', 'Diverticulitis-defined-Abdominal Pain', 'Diverticulitis-treat-Fever', 'Wounds and Injuries-set-Death', 'Wounds and Injuries-exhibit-Death', 'Inflammation-include-Arbovirus Infections', 'Mitochondrial Diseases-include-Arbovirus Infections', 'Brain Injuries, Traumatic-code-Malocclusion', 'Joint Diseases-cause-Pain', 'Joint Diseases-cause-Inflammation', 'Pain-cause-Inflammation', 'Musculoskeletal Diseases-represent-Death', 'Osteoarthritis-occur-Joint Diseases', 'Central Nervous System Diseases-prevent-Osteoarthritis', 'Infections-defend-Neoplasms', 'Infections-defend-Autoimmune Diseases', 'Pulmonary Disease, Chronic Obstructive-contribute-Lung Neoplasms', 'Pulmonary Disease, Chronic Obstructive-contribute-Colorectal Neoplasms', 'Pulmonary Disease, Chronic Obstructive-contribute-Carcinoma, Hepatocellular', 'Pulmonary Disease, Chronic Obstructive-contribute-Neoplasms', 'Progeria-exhibit-Skin Abnormalities', 'Progeria-exhibit-Osteoporosis', 'Progeria-succumb-Cardiovascular Diseases', 'Skin Abnormalities-succumb-Cardiovascular Diseases', 'Osteoporosis-succumb-Cardiovascular Diseases', 'Glaucoma-develop-Dementia', 'Glaucoma-develop-Alzheimer Disease', 'Cataract-develop-Dementia', 'Cataract-develop-Alzheimer Disease', 'Renal Insufficiency, Chronic-recommended-Hypertension', 'Renal Insufficiency, Chronic-manage-Acidosis', 'Infections-linked-Myocardial Infarction', 'Infections-linked-Cardiovascular Diseases', 'Myocardial Infarction-linked-Cardiovascular Diseases', 'Inflammation-progress-Cardiovascular Diseases', 'Infections-associated-Respiratory Distress Syndrome', 'Respiratory Distress Syndrome-associated-Infections', 'Heart Arrest-precipitate-Neoplasms', 'Hepatitis C-remain-Infections', 'Seizures-live-Diabetes Mellitus', 'Pneumonia-increase-Tooth Diseases', 'Headache-reported-Taste Disorders', 'Postoperative Complications-reveal-Postpartum Hemorrhage', 'Diabetes Mellitus-include-Hypotension', 'Hip Fractures-suffer-Osteoporosis', 'Hypertension-monitored-Severe Dengue', 'Abdominal Pain-monitored-Severe Dengue', 'Hypertension-associated-Severe Dengue', 'Severe Dengue-associated-Hypertension', 'Abdominal Pain-associated-Severe Dengue', 'Severe Dengue-associated-Abdominal Pain', 'Cardiovascular Diseases-evaluated-Obesity', 'Disease Progression-present-Calcinosis', 'Disease Progression-present-Aortic Valve Stenosis', 'Infections-present-Delirium', 'Hypertension-lead-Myocardial Infarction', 'Obesity-lead-Myocardial Infarction', 'Hyperemia-associated-Cardiomyopathies', 'Cardiomyopathies-associated-Hyperemia', 'Neoplasms-developed-Drug-Related Side Effects and Adverse Reactions', 'Venous Thromboembolism-assess-Wounds and Injuries', 'Venous Thromboembolism-develop-Wounds and Injuries', 'Wounds and Injuries-associated-Venous Thromboembolism', 'Venous Thromboembolism-associated-Wounds and Injuries', 'Wounds and Injuries-initiate-Venous Thromboembolism', 'Brain Injuries, Traumatic-associated-Venous Thromboembolism', 'Venous Thromboembolism-associated-Brain Injuries, Traumatic', 'Brain Injuries, Traumatic-initiate-Venous Thromboembolism', 'Acute Coronary Syndrome-differ-Neoplasms', 'Death-adjusted-Stroke', 'Thyroid Diseases-treat-Hypothyroidism', 'Neoplasms-treat-Hypothyroidism', 'Death-treat-Hypothyroidism', 'Genetic Diseases, Inborn-discovered-Lymphohistiocytosis, Hemophagocytic', 'Multiple Sclerosis-include-Nervous System Diseases', 'Cardiac Output, Low-followed-Pain', 'Skin Diseases, Vesiculobullous-affect-Wounds and Injuries', 'Thyroid Carcinoma, Anaplastic-diagnosed-Rhabdoid Tumor', 'Thyroid Cancer, Papillary-base-Rhabdoid Tumor', 'Neoplasm Metastasis-reveal-Thyroid Carcinoma, Anaplastic', 'Sex Cord-Gonadal Stromal Tumors-induce-Hypoxia', 'Purpura Fulminans-develop-Bacteremia', 'Shock, Septic-develop-Bacteremia', 'Death-related-Leukemia, Myeloid, Acute', 'Obesity-correlated-Death', 'Obesity-correlated-Infections', 'Cataract-include-Hematologic Diseases', 'Sarcopenia-correlate-Malnutrition', 'Endocrine System Diseases-develop-Infections', 'Thyroid Diseases-exclude-Neoplasms', 'Thyroid Diseases-exclude-Respiration Disorders', 'Neoplasms-include-Respiration Disorders', 'Neoplasms-exclude-Respiration Disorders', 'Cardiovascular Diseases-defined-Infarction', 'Cardiovascular Diseases-defined-Hemorrhage', 'Cardiovascular Diseases-defined-Shock, Cardiogenic', 'Death-show-Adenomatous Polyposis Coli', 'Obesity-determined-Obesity, Abdominal', 'Obesity-base-Obesity, Abdominal', 'Diabetes Mellitus-associated-Pneumonia', 'Pneumonia-associated-Diabetes Mellitus', 'Heart Failure-associated-Pneumonia', 'Pneumonia-associated-Heart Failure', 'Lipid Metabolism Disorders-lead-Liver Diseases', 'Tuberculosis-associated-Pneumonia', 'Pneumonia-associated-Tuberculosis', 'Atrial Fibrillation-associated-Pneumonia', 'Pneumonia-associated-Atrial Fibrillation', 'Renal Insufficiency, Chronic-associated-Pneumonia', 'Pneumonia-associated-Renal Insufficiency, Chronic', 'Cerebrovascular Disorders-associated-Pneumonia', 'Pneumonia-associated-Cerebrovascular Disorders', 'Pulmonary Disease, Chronic Obstructive-associated-Pneumonia', 'Pneumonia-associated-Pulmonary Disease, Chronic Obstructive', 'Epilepsy-associated-Pneumonia', 'Pneumonia-associated-Epilepsy', 'Substance-Related Disorders-associated-Pneumonia', 'Pneumonia-associated-Substance-Related Disorders', 'Pneumonia-lower-Dyslipidemias', 'Renal Insufficiency, Chronic-lead-Death', 'Malabsorption Syndromes-occur-Weight Loss', 'Malabsorption Syndromes-occur-Sarcopenia', 'Osteoarthritis-manifest-Hypertrophy', 'Tibial Meniscus Injuries-promote-Osteoarthritis', 'Hypertension-associated-Osteoarthritis', 'Osteoarthritis-associated-Hypertension', 'Neoplasms-protect-Ovarian Diseases', 'Heart Failure-associated-Bone Diseases, Metabolic', 'Bone Diseases, Metabolic-associated-Heart Failure', 'Osteoporosis-remain-Heart Failure', 'Infertility, Female-incorporated-Endometriosis', 'Bone Neoplasms-lead-Fractures, Bone', 'Osteoporosis-affected-Osteoarthritis', 'Pneumonia-occur-Cardiovascular Diseases', 'Diabetic Nephropathies-progress-Renal Insufficiency', 'Anemia, Iron-Deficiency-associated-Hearing Loss', 'Hearing Loss-associated-Anemia, Iron-Deficiency', 'Anemia, Sickle Cell-associated-Hearing Loss', 'Hearing Loss-associated-Anemia, Sickle Cell', 'Anemia-associated-Hearing Loss', 'Hearing Loss-associated-Anemia', 'Communicable Diseases-evaluated-Death', 'Communicable Diseases-predict-Death', 'Death-pertain-Cardiovascular Diseases', 'Edema-affected-Deglutition Disorders', 'Pneumonia, Aspiration-cause-Spinal Cord Injuries', 'Pneumonia, Aspiration-cause-Deglutition Disorders', 'Alzheimer Disease-show-Nerve Degeneration', 'Alzheimer Disease-put-Heart Diseases', 'Alzheimer Disease-put-Neoplasms', 'Death-put-Heart Diseases', 'Death-put-Neoplasms', 'Infections-result-Immunologic Deficiency Syndromes', 'Immunologic Deficiency Syndromes-result-Infections', 'Urinary Bladder, Neurogenic-predispose-Alzheimer Disease', 'Riboflavin Deficiency-combine-Genetic Diseases, Inborn', 'Riboflavin Deficiency-combine-Infections', 'Pneumonia-appear-Pulmonary Disease, Chronic Obstructive', 'Pulmonary Disease, Chronic Obstructive-differ-Pneumonia', 'Anemia, Iron-Deficiency-cause-Gastrointestinal Diseases', 'Postpartum Hemorrhage-cause-Gastrointestinal Diseases', 'Airway Obstruction-associated-Paralysis', 'Paralysis-associated-Airway Obstruction', 'Airway Obstruction-associated-Spasm', 'Spasm-associated-Airway Obstruction', 'Airway Obstruction-associated-Jaw Diseases', 'Jaw Diseases-associated-Airway Obstruction', 'Atrial Fibrillation-represent-Arrhythmias, Cardiac', 'Atrial Fibrillation-constitute-Heart Failure', 'Atrial Fibrillation-constitute-Pulmonary Embolism', 'Atrial Fibrillation-constitute-Dementia', 'Infections-report-Death', 'Coronary Artery Disease-include-Hypertension', 'Acute Kidney Injury-detected-Kidney Diseases', 'Renal Insufficiency, Chronic-resected-Pyelonephritis', 'Diabetes Mellitus-counterbalanced-Hemorrhage', 'Cardiovascular Diseases-counterbalanced-Hemorrhage', 'Alzheimer Disease-revealed-Cerebrovascular Disorders', 'Obesity-underlie-Heart Diseases', 'Wounds and Injuries-characterized-Osteochondritis', 'Joint Diseases-extract-Osteoarthritis', 'Diabetes Mellitus-known-Sarcopenia', 'Dyspnea-progress-Respiratory Distress Syndrome', 'Dyspnea-progress-Blood Coagulation Disorders', 'Dyspnea-progress-Multiple Organ Failure', 'Immunologic Deficiency Syndromes-ascribed-Bone Neoplasms', 'Immunologic Deficiency Syndromes-prevent-Bone Neoplasms', 'Pneumonia-reduce-Death', 'Hypertension-remain-Stroke', 'Hypertension-remain-Myocardial Infarction', 'Dementia-believed-Alzheimer Disease', 'Dementia-believed-Brain Diseases', 'Dementia-believed-Death', 'Fibrosis-protect-Renal Insufficiency, Chronic', 'Cheyne-Stokes Respiration-associated-Sleep Apnea Syndromes', 'Sleep Apnea Syndromes-associated-Cheyne-Stokes Respiration', 'Cheyne-Stokes Respiration-defined-Sleep Apnea Syndromes', 'Sarcopenia-increase-Osteoporosis', 'Calcinosis-related-Multiple Chronic Conditions', 'Lyme Disease-result-Myocarditis', 'Lyme Disease-result-Arthritis', 'Lyme Disease-result-Facial Paralysis', 'Heart Diseases-experience-Arrhythmias, Cardiac', 'Arrhythmias, Cardiac-experience-Heart Defects, Congenital', 'Myocarditis-followed-Meningitis', 'Arrhythmias, Cardiac-occur-Heart Diseases', 'Fractures, Bone-ascertained-Death', 'Calcinosis-encountered-Renal Insufficiency, Chronic', 'Calcinosis-reach-Stenosis, Pulmonary Artery', 'Calcinosis-described-Mitral Valve Stenosis', 'Stroke-exhibit-Deglutition Disorders', 'Deglutition Disorders-suffer-Malnutrition', 'Osteoarthritis-associated-Fractures, Bone', 'Fractures, Bone-associated-Osteoarthritis', 'Acute Kidney Injury-characterized-Renal Insufficiency, Chronic', 'Sepsis-associated-Acute Kidney Injury', 'Acute Kidney Injury-associated-Sepsis', 'Sepsis-associated-Renal Insufficiency, Chronic', 'Renal Insufficiency, Chronic-associated-Sepsis', 'Ischemia-associated-Acute Kidney Injury', 'Acute Kidney Injury-associated-Ischemia', 'Ischemia-associated-Renal Insufficiency, Chronic', 'Renal Insufficiency, Chronic-associated-Ischemia', 'Pain-arise-Neurodegenerative Diseases', 'Sleep Initiation and Maintenance Disorders-arise-Neurodegenerative Diseases', 'Infections-yield-Respiratory Tract Diseases', 'Pulmonary Embolism-include-Thromboembolism', 'Venous Thrombosis-include-Thromboembolism', 'Venous Thromboembolism-include-Thromboembolism', 'Stroke-include-Thromboembolism', 'Venous Thrombosis-include-Pulmonary Embolism', 'Venous Thromboembolism-include-Pulmonary Embolism', 'Stroke-include-Pulmonary Embolism', 'Respiratory Tract Infections-cause-Inflammation', 'Respiratory Tract Infections-cause-Neurodegenerative Diseases', 'Heart Failure-suggest-Cardiovascular Diseases', 'Amyloidosis-observed-Diabetes Mellitus', 'Death-impair-Blood Coagulation Disorders', 'Pneumonia-impair-Blood Coagulation Disorders', 'Coronavirus Infections-infect-Infections', 'Headache-include-Myalgia', 'Hemoptysis-include-Myalgia', 'Diarrhea-include-Myalgia', 'Fibrosis-interrupt-Diabetic Cardiomyopathies', 'Hypertrophy-interrupt-Diabetic Cardiomyopathies', 'Anemia, Sickle Cell-suffer-Inflammation', 'Anemia, Sickle Cell-suffer-Ischemic Attack, Transient', 'Anemia, Sickle Cell-suffer-Death', 'Coronary Artery Disease-elicited-Anemia, Sickle Cell', 'Infections-diagnosed-Death', 'Leukemia, Myelogenous, Chronic, BCR-ABL Positive-elevated-Chronic Disease', 'Diabetes Mellitus, Type 2-correlated-Leukemia, Myelogenous, Chronic, BCR-ABL Positive', 'Multiple Myeloma-seem-Infections', 'Multiple Myeloma-avoid-Infections', 'Hematoma-threat-Compartment Syndromes', 'Hematoma-threat-Infections', 'Neoplasms-lead-Chemical and Drug Induced Liver Injury', 'Sarcopenia-involved-Cardiovascular Diseases', 'Neurodegenerative Diseases-related-Cardiomyopathies', 'Neurodegenerative Diseases-related-Heart Failure', 'Cardiovascular Diseases-result-Muscular Diseases', 'Cardiovascular Diseases-induced-Atherosclerosis', 'Muscular Diseases-induced-Atherosclerosis', 'Cataract-considered-Blindness', 'Corneal Opacity-considered-Blindness', 'Glaucoma-considered-Blindness', 'Refractive Errors-considered-Cataract', 'Cataract-considered-Corneal Opacity', 'Cataract-considered-Glaucoma', 'Refractive Errors-considered-Corneal Opacity', 'Refractive Errors-considered-Glaucoma', 'Refractive Errors-considered-Blindness', 'Diabetes Mellitus-lead-Vision Disorders', 'Diabetes Mellitus-associated-Eye Pain', 'Eye Pain-associated-Diabetes Mellitus', 'Blood Protein Disorders-lead-Cataract', 'Fractures, Bone-identified-Femoral Neck Fractures', 'Anemia-associated-Osteoporosis', 'Osteoporosis-associated-Anemia', 'Osteoporotic Fractures-base-Sarcopenia', 'Osteoporotic Fractures-base-Anemia', 'Anemia-compare-Osteoporotic Fractures', 'Neoplasms-develop-Colorectal Neoplasms', 'Neoplasms-develop-Urinary Bladder Neoplasms', 'Carcinogenesis-cause-Anemia', 'Death-destined-Necrosis', 'Infections-incubate-Carcinogenesis', 'Multiple Sclerosis-suggest-Fatigue', 'Infections-cause-Dysentery', 'Atrophy-include-Glycogen Storage Disease Type II', 'Neovascularization, Pathologic-include-Glycogen Storage Disease Type II', 'Aphasia-examine-Dysarthria', 'Sarcopenia-address-Diabetes Mellitus, Type 2', 'Pulmonary Disease, Chronic Obstructive-suggested-Muscle Weakness', 'Coronary Artery Disease-include-Atherosclerosis', 'Myocardial Infarction-include-Atherosclerosis', 'Cerebrovascular Disorders-include-Atherosclerosis', 'Inflammation-include-HIV Infections', 'Chronic Disease-include-HIV Infections', 'Vitiligo-lose-Pigmentation Disorders', 'Skin Diseases-lose-Pigmentation Disorders', 'Venous Thrombosis-associated-Thrombosis', 'Thrombosis-associated-Venous Thrombosis', 'Osteoarthritis-impact-Pain', 'Heart Diseases-include-Chronic Disease', 'Lung Injury-lead-Respiratory Distress Syndrome', 'Scleroderma, Systemic-characterized-Lung Diseases, Interstitial', 'Scleroderma, Systemic-characterized-Pulmonary Arterial Hypertension', 'Scleroderma, Systemic-compare-Coronary Artery Disease', 'Scleroderma, Systemic-characterized-Coronary Artery Disease', 'Scleroderma, Systemic-develop-Aneurysm', 'Scleroderma, Systemic-develop-Raynaud Disease', 'Scleroderma, Systemic-develop-Ischemia', 'Scleroderma, Systemic-develop-Pulmonary Arterial Hypertension', 'Scleroderma, Systemic-identify-Aneurysm', 'Scleroderma, Systemic-identify-Pulmonary Arterial Hypertension', 'Scleroderma, Systemic-help-Pulmonary Arterial Hypertension', 'Infections-resulting-Seizures', 'Aneurysm-develop-Pulmonary Arterial Hypertension', 'Raynaud Disease-develop-Pulmonary Arterial Hypertension', 'Ischemia-develop-Pulmonary Arterial Hypertension', 'Heart Failure-increase-Hemorrhage', 'Cerebrovascular Disorders-play-Renal Insufficiency, Chronic', 'Ulcer-fall-Cardiac Output, Low', 'Ulcer-stumble-Epiglottitis', 'Inflammation-involved-Infections', 'Ulcer-fall-Supraglottitis', 'Bacteremia-fall-Cardiac Output, Low', 'Bacteremia-contaminated-Epiglottitis', 'Bacteremia-result-Supraglottitis', 'Cardiac Output, Low-stumble-Infections', 'Cardiac Output, Low-fall-Epiglottitis', 'Cardiac Output, Low-fall-Supraglottitis', 'Infections-contaminated-Epiglottitis', 'Infections-result-Supraglottitis', 'Dementia-increase-Obesity', 'Hip Fractures-increase-Obesity', 'Neoplasms-affect-Seizures', 'Seizures-suppress-Neoplasms', 'Renal Insufficiency, Chronic-associated-Proteinuria', 'Proteinuria-associated-Renal Insufficiency, Chronic', 'Cutis Laxa-lead-Nervous System Diseases', 'Metabolism, Inborn Errors-lead-Nervous System Diseases', 'Death-classified-Drug Overdose', 'Drug Overdose-calculate-HIV Infections', 'Osteoarthritis-improve-Joint Diseases', 'Neoplasms-cause-Intellectual Disability', 'Inflammation-demonstrated-Skin Diseases', 'Neurodegenerative Diseases-recognized-Alzheimer Disease', 'Inflammation-demonstrated-Dermatitis, Atopic', 'Inflammation-demonstrated-Eczema', 'Ventricular Remodeling-studied-Cardiomegaly', 'Ventricular Remodeling-studied-Fibrosis', 'Ventricular Remodeling-inhibit-Fibrosis', 'Ventricular Remodeling-inhibit-Inflammation', 'Fibrosis-inhibit-Inflammation', 'Myocarditis-result-Heart Failure', 'Myocarditis-result-Heart Diseases', 'Hypercholesterolemia-followed-Hyperlipidemias', 'Hemorrhage-associated-Thoracic Outlet Syndrome', 'Thoracic Outlet Syndrome-associated-Hemorrhage', 'Neoplasms-associated-Postpartum Hemorrhage', 'Postpartum Hemorrhage-associated-Neoplasms', 'Inflammation-identified-Neurodegenerative Diseases', 'Inflammation-identified-Alzheimer Disease', 'Inflammation-generated-Toxoplasmosis', 'Cardiovascular Diseases-affect-Death', 'Aging, Premature-characterized-Atherosclerosis', 'Progeria-associated-Atherosclerosis', 'Atherosclerosis-associated-Progeria', 'Inflammation-increase-Heart Arrest', 'Headache Disorders, Secondary-experience-Primary Ovarian Insufficiency', 'Osteoporosis-experience-Primary Ovarian Insufficiency', 'Chronic Disease-experience-Primary Ovarian Insufficiency', 'Colitis, Ulcerative-followed-Inflammatory Bowel Diseases', 'Stroke-recorded-Dementia', 'Arterial Occlusive Diseases-observed-Dementia', 'Dementia-increase-Fractures, Open', 'Heart Failure-improve-Chronic Disease', 'Heart Failure-compare-Death', 'Cardiovascular Abnormalities-extended-Heart Failure, Diastolic', 'Ataxia-used-Sarcopenia', 'Ataxia-define-Sarcopenia', 'Ataxia-evaluate-Syncope', 'Sarcopenia-evaluate-Syncope', 'Respiratory Tract Diseases-cause-Death', 'Death-include-Respiration Disorders', 'Cold Injury-include-Respiratory Tract Diseases', 'Pneumonia-include-Respiratory Tract Diseases', 'Communicable Diseases-inflict-Death', 'Dysbiosis-contribute-Wounds and Injuries', 'Communicable Diseases-become-Obesity', 'Diabetes Mellitus-impair-Memory Disorders', 'Diabetes Mellitus-include-Ankle Fractures', 'Osteoporosis-include-Ankle Fractures', 'Sarcopenia-define-Oculocerebrorenal Syndrome', 'Zoonoses-named-Infections', 'Sjogren-Larsson Syndrome-treat-Muscular Diseases', 'Joint Diseases-occur-Infections', 'Osteoarthritis-occur-Infections', 'Arthritis-occur-Infections', 'Arthritis, Infectious-occur-Infections', 'Heart Diseases-reduced-Diabetes Mellitus', 'Inflammation-proposed-Neoplasms', 'Inflammation-reduce-Hematologic Neoplasms', 'Pain-block-Hip Fractures', 'Myocardial Infarction-explore-Death', 'Myocardial Infarction-explore-Heart Failure', 'Myocardial Infarction-explore-Myocarditis', 'Myocardial Infarction-explore-Cardiotoxicity', 'Delirium-increase-Postoperative Complications', 'Eclampsia-superimpose-Hypertension', 'Dementia-course-Memory Disorders', 'Alzheimer Disease-course-Memory Disorders', 'Infections-treat-Hip Fractures', 'Hip Fractures-treat-Cross Infection', 'Glioblastoma-account-Brain Neoplasms', 'Glioblastoma-account-Glioma', 'Hypertension-lead-Heart Diseases', 'Hypertension-lead-Stroke', 'Hypertension-lead-Renal Insufficiency', 'Atherosclerosis-include-Cardiovascular Diseases', 'Infections-correlated-Death', 'Obesity-treat-Fatigue', 'Obesity-impact-Pain', 'Fatigue-impact-Pain', 'Neoplasms-diagnose-Neoplasm Metastasis', 'Neoplasm Metastasis-presented-Medulloblastoma', 'Metabolic Diseases-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-Metabolic Diseases', 'Brain Injuries, Traumatic-decrease-Hydrocephalus', 'Wounds and Injuries-decrease-Hydrocephalus', 'Hydrocephalus-involve-Venous Insufficiency', 'Neurologic Manifestations-participate-Hypotension, Orthostatic', 'Hypotension, Orthostatic-detected-Hypertension', 'Inflammation-associated-Fatty Liver', 'Fatty Liver-associated-Inflammation', 'Wounds and Injuries-occur-HIV Infections', 'Urinary Bladder Diseases-characterized-Inflammation', 'Diabetes Mellitus-accompany-Dyslipidemias', 'Diabetes Mellitus-see-Lipodystrophy', 'Dyslipidemias-see-Lipodystrophy', 'Wounds and Injuries-centered-HIV Infections', 'HIV Infections-include-Wounds and Injuries', 'Peripheral Vascular Diseases-include-Pain', 'Tuberculosis-include-Communicable Diseases', 'Cardiomyopathy, Hypertrophic-represented-Death, Sudden, Cardiac', 'Cardiomyopathy, Hypertrophic-represented-Tachycardia, Ventricular', 'Cardiomyopathy, Hypertrophic-represented-Ventricular Fibrillation', 'Cardiomyopathy, Hypertrophic-represent-Death, Sudden, Cardiac', 'Neoplasms-matched-Cardiovascular Diseases', 'Non-alcoholic Fatty Liver Disease-pose-Death', 'Asthma-include-Obesity', 'Musculoskeletal Diseases-include-Obesity', 'Obesity-include-Coronary Artery Disease', 'Obesity-include-Hypertension', 'Obesity-include-Stroke', 'Coronary Artery Disease-contribute-Death', 'Infertility, Female-impending-Primary Ovarian Insufficiency', 'Ovarian Neoplasms-impending-Primary Ovarian Insufficiency', 'Compartment Syndromes-become-Hip Fractures', 'Compartment Syndromes-administered-Hip Fractures', 'Weight Loss-missed-Obesity', 'Sarcopenia-increase-Drug-Related Side Effects and Adverse Reactions', 'Death-indicate-Cardiovascular Diseases', 'Death-indicate-Diabetes Mellitus', 'Death-indicate-Renal Insufficiency, Chronic', 'Idiopathic Pulmonary Fibrosis-include-Communicable Diseases', 'Communicable Diseases-include-Chronic Disease', 'Hypertension-associated-Pain', 'Pain-associated-Hypertension', 'Venous Thromboembolism-related-Fractures, Compression', 'Diabetes Mellitus-associated-Melanoma', 'Melanoma-associated-Diabetes Mellitus', 'Leukoaraiosis-increase-Hemorrhage', 'Inflammation-play-Prostatic Neoplasms', 'Inflammatory Bowel Diseases-compared-Pneumonia', 'Inflammatory Bowel Diseases-compared-Death', 'Alzheimer Disease-stand-Dementia', 'Mitochondrial Diseases-lead-Proteostasis Deficiencies', 'Immunologic Deficiency Syndromes-induce-Fasciculation', 'Immunologic Deficiency Syndromes-induce-Sarcopenia', 'Fasciculation-induce-Sarcopenia', 'Pain-decrease-Death', 'Kidney Diseases-shown-Acute Kidney Injury', 'Acute Kidney Injury-associate-Hypertension', 'Hypertension-associate-Acute Kidney Injury', 'Acute Kidney Injury-associate-Diabetes Mellitus', 'Diabetes Mellitus-associate-Acute Kidney Injury', 'Stroke-summarised-Hemorrhage', 'Obesity-lead-Cachexia', 'Ankle Injuries-determined-Pain', 'Ankle Injuries-base-Pain', 'Neck Pain-show-Bilateral Vestibulopathy', 'Wounds and Injuries-show-Bilateral Vestibulopathy', 'Sarcoma-linked-Mitochondrial Diseases', 'Amyotrophic Lateral Sclerosis-include-Nervous System Diseases', 'Spinocerebellar Ataxias-include-Nervous System Diseases', 'Arbovirus Infections-include-Nervous System Diseases', 'Osteoarthritis-play-Cartilage Diseases', 'Delirium-lead-Death', 'Hypotension-include-Dementia', 'Diabetes Mellitus-caused-Adrenal Insufficiency', 'Endocrine System Diseases-caused-Adrenal Insufficiency', 'Metabolic Diseases-caused-Adrenal Insufficiency', 'Kidney Diseases-combined-Acute Kidney Injury', 'Carotid Artery Diseases-associated-Hypoxia', 'Hypoxia-associated-Carotid Artery Diseases', 'Calcinosis-undergo-Aneurysm', 'Calcinosis-undergo-Death', 'Chronic Pain-compare-Fatigue', 'Fatigue-compare-Pain', 'Bone Marrow Diseases-reported-Diabetes Mellitus, Type 2', 'Bone Marrow Diseases-reported-Ischemia', 'Aneurysm-associated-Hypertension', 'Hypertension-associated-Aneurysm', 'Aneurysm-associated-Fibrosis', 'Fibrosis-associated-Aneurysm', 'Inflammation-induce-Chronic Disease', 'Inflammation-stimulate-Fibrosis', 'Inflammation-stimulate-Emphysema', 'Pneumonia-observed-Death', 'Atrial Fibrillation-undergo-Hemorrhage', 'Death-focus-Weight Loss', 'Lung Diseases-report-Vision Disorders', 'Liver Failure-increase-Fibrosis', 'Neoplasms-identify-Heart Diseases', 'Neoplasms-identify-Death', 'Hypertriglyceridemia-decrease-Fibrosis', 'Heart Diseases-decreasing-Death', 'Neoplasms-decreasing-Death', 'Neoplasms-increase-Heart Diseases', 'Sleep Deprivation-underlie-Delirium', 'Arthritis-suffer-Angina Pectoris', 'Dysbiosis-lead-Inflammation', 'Inflammation-seen-Obesity', 'Immunologic Deficiency Syndromes-diagnosed-Respiratory Distress Syndrome', 'Death-diagnosed-Respiratory Distress Syndrome', 'Respiratory Distress Syndrome-increase-Death', 'Immunologic Deficiency Syndromes-include-Respiratory Distress Syndrome', 'Colorectal Neoplasms-diagnosed-Neoplasms', 'Pancreatitis, Graft-associated-Death', 'Death-associated-Pancreatitis, Graft', 'Sleep Apnea Syndromes-associated-Obesity', 'Obesity-associated-Sleep Apnea Syndromes', 'Appendicitis-define-Gangrene', 'Appendicitis-define-Diverticulitis', 'Neoplasms-calculate-Death', 'Inflammation-include-Appendiceal Neoplasms', 'Fibrosis-include-Appendiceal Neoplasms', 'Neoplasms-include-Appendiceal Neoplasms', 'Hip Fractures-increased-Dementia', 'Hip Fractures-increased-Delirium', 'Atherosclerosis-show-Metabolic Diseases', 'Vision Disorders-result-Atrophy', 'Pancreatitis-prevent-Shock', 'Coronavirus Infections-include-Fever', 'Coronavirus Infections-include-Cough', 'Neoplasms-accompanied-Calcinosis', 'Heart Neoplasms-accompanied-Calcinosis', 'Benign Paroxysmal Positional Vertigo-fall-Cardiac Output, Low', 'Muscle Spasticity-serve-Ataxia', 'Muscle Spasticity-serve-Weight Loss', 'Renal Insufficiency, Chronic-increased-Vascular Calcification', 'Renal Insufficiency, Chronic-undergo-Vascular Calcification', 'Renal Insufficiency, Chronic-involve-Vascular Calcification', 'Sleep Apnea, Obstructive-range-Stroke', 'Atrial Fibrillation-increase-Dementia', 'Atrial Fibrillation-link-Dementia', 'Atrial Fibrillation-link-Stroke', 'Neoplasms-use-Colorectal Neoplasms', 'Atrophy-demonstrate-Alzheimer Disease', 'Signs and Symptoms, Digestive-observed-Drug Hypersensitivity', 'Dyspepsia-observed-Drug Hypersensitivity', 'Abdominal Pain-observed-Drug Hypersensitivity', 'Obesity-associated-Bone Diseases, Metabolic', 'Bone Diseases, Metabolic-associated-Obesity', 'Diarrhea-observed-Drug Hypersensitivity', 'Diabetes Mellitus, Type 2-induce-Cerebral Infarction', 'Diabetes Mellitus, Type 2-induce-Dementia, Vascular', 'Diabetes Mellitus, Type 2-induce-Dementia', 'Cerebral Infarction-induce-Dementia', 'Diabetes Mellitus, Type 2-affect-Dementia, Vascular', 'Diabetes Mellitus, Type 2-affect-Dementia', 'Diabetes Mellitus, Type 2-delay-Alzheimer Disease', 'Cerebral Infarction-affect-Dementia, Vascular', 'Cerebral Infarction-affect-Dementia', 'Cerebral Infarction-delay-Alzheimer Disease', 'Dementia, Vascular-affect-Dementia', 'Dementia, Vascular-delay-Alzheimer Disease', 'Dementia-delay-Alzheimer Disease', 'Diabetes Mellitus-contribute-Inflammation', 'Osteoporotic Fractures-receive-Pain', 'Colitis-cause-Digestive System Neoplasms', 'Digestive System Neoplasms-range-Diarrhea', 'Digestive System Neoplasms-cause-Death', 'Sarcopenia-require-Death', 'Cardiovascular Diseases-influence-HIV Infections', 'Neoplasms, Second Primary-assess-Colorectal Neoplasms', 'Neoplasms-include-Neurodegenerative Diseases', 'Cardiovascular Diseases-lead-Pneumonia', 'Kidney Diseases-cause-Immune System Diseases', 'Infections-cause-Immune System Diseases', 'Arbovirus Infections-associated-Fever', 'Fever-associated-Arbovirus Infections', 'Arbovirus Infections-associated-Cough', 'Cough-associated-Arbovirus Infections', 'Arbovirus Infections-associated-Bronchiolitis', 'Bronchiolitis-associated-Arbovirus Infections', 'Alzheimer Disease-diagnose-Dementia', 'Death-display-Aneurysm', 'Synucleinopathies-delay-Communicable Diseases', 'Diabetes Mellitus-minimize-Death', 'Delirium-affect-Pain', 'Sleep Deprivation-include-Pain', 'Sleep Deprivation-include-Delirium', 'Pain-require-Delirium', 'Dementia-require-Delirium', 'Delirium-assess-Pain', 'Coronary Artery Disease-cause-Communicable Diseases', 'Death-cause-Communicable Diseases', 'Osteoporotic Fractures-classify-Sarcopenia', 'Thyroid Neoplasms-face-Drug-Related Side Effects and Adverse Reactions', 'Postoperative Complications-reduce-Anemia', 'Postoperative Complications-reduce-Death', 'Neoplasms-see-Chronic Disease', 'Tauopathies-include-Dementia', 'Neoplasms-potentiate-Muscle Weakness', 'Nervous System Diseases-exacerbated-Neurotoxicity Syndromes', 'Nervous System Diseases-result-Neurologic Manifestations', 'Neurotoxicity Syndromes-result-Neurologic Manifestations', 'Ventricular Dysfunction, Left-reduce-Cardiovascular Diseases', 'Drug-Related Side Effects and Adverse Reactions-model-Liver Diseases', 'Anemia-fall-Cardiac Output, Low', 'Cerebral Hemorrhage-alleviate-Alzheimer Disease', 'Diabetes Mellitus-drive-Fibrosis', 'Autoimmune Diseases-drive-Fibrosis', 'Hallucinations-linked-Fibrosis', 'Herpes Zoster-associated-Neuralgia', 'Neuralgia-associated-Herpes Zoster', 'Inflammation-extend-Fistula', 'Cataract-enhance-Ocular Hypertension', 'Osteoporotic Fractures-include-Chronic Disease', 'Joint Dislocations-involved-Vision Disorders', 'Heart Failure-seen-Arteriovenous Fistula', 'Retinitis-distinguished-Multiple Sclerosis', 'Atrial Fibrillation-underlie-Heart Diseases', 'Diabetes Mellitus-increase-Atrial Fibrillation', 'Obesity-increase-Atrial Fibrillation', 'Hypertension-increase-Atrial Fibrillation', 'Hyperthyroidism-increase-Atrial Fibrillation', 'Melanoma-include-Neoplasms', 'Alzheimer Disease-prevent-Dementia', 'Neoplasms-diagnosed-Digestive System Neoplasms', 'Anemia, Aplastic-diagnosed-Myelodysplastic Syndromes', 'Anemia, Aplastic-diagnosed-Leukemia, Myeloid, Acute', 'Thoracic Outlet Syndrome-reduced-Multiple Sclerosis', 'Fever-include-Infections', 'Cough-include-Infections', 'Constipation-increase-Kidney Calculi', 'Death-defined-Wounds and Injuries', 'Hemolytic-Uremic Syndrome-contribute-Death', 'Hemolytic-Uremic Syndrome-contribute-Renal Insufficiency, Chronic', 'Memory Disorders-destabilize-Atherosclerosis', 'Inflammation-destabilize-Atherosclerosis', 'Kidney Failure, Chronic-destabilize-Atherosclerosis', 'Hypesthesia-use-Pain', 'Dementia-detect-Critical Illness', 'Dementia-suspected-Critical Illness', 'Sleep Deprivation-considered-Alzheimer Disease', 'Sleep Disorders, Circadian Rhythm-considered-Alzheimer Disease', 'Renal Insufficiency, Chronic-present-Death', 'Tuberculosis-include-Death', 'Pneumonia-include-Death', 'Lung Diseases, Interstitial-include-Death', 'Tuberculosis-include-Respiratory Tract Diseases', 'Lung Diseases, Interstitial-include-Respiratory Tract Diseases', 'Gyrate Atrophy-prevent-Neurologic Manifestations', 'Brain Diseases-prevent-Neurologic Manifestations', 'Hyperammonemia-related-Metabolic Diseases', 'Hyperammonemia-thought-Metabolic Diseases', 'Gyrate Atrophy-considered-Brain Diseases', 'Atrial Fibrillation-assess-Cerebral Infarction', 'Atrial Fibrillation-calculate-Stroke', 'Atrial Fibrillation-associate-Stroke', 'Stroke-associate-Atrial Fibrillation', 'Fibrosis-include-Hypertension', 'Hypertension-predict-Fibrosis', 'Sleep Apnea, Obstructive-characterized-Airway Obstruction', 'Sleep Wake Disorders-characterized-Airway Obstruction', 'Dementia-measure-Memory Disorders', 'Parkinson Disease-described-Neurodegenerative Diseases', 'Multiple Sclerosis-described-Neurodegenerative Diseases', 'Obesity-associated-Hypertrophy, Left Ventricular', 'Hypertrophy, Left Ventricular-associated-Obesity', 'Obesity-associated-Atherosclerosis', 'Atherosclerosis-associated-Obesity', 'Hypertrophy, Left Ventricular-associated-Atherosclerosis', 'Atherosclerosis-associated-Hypertrophy, Left Ventricular', 'Obesity-associated-Heart Diseases', 'Heart Diseases-associated-Obesity', 'Diabetes Mellitus-classified-Obesity', 'Endocrine System Diseases-classified-Obesity', 'Brain Injuries, Traumatic-initiate-Cerebrovascular Disorders', 'Alzheimer Disease-initiate-Cerebrovascular Disorders', 'Arthritis-associated-Atrial Fibrillation', 'Atrial Fibrillation-associated-Arthritis', 'Angina Pectoris-associated-Atrial Fibrillation', 'Atrial Fibrillation-associated-Angina Pectoris', 'Infections-result-Lung Injury', 'Infections-result-Heart Diseases', 'Waterborne Diseases-receive-Stroke', 'Colorectal Neoplasms-promote-Death', 'Diabetes Mellitus-followed-Hypertension', 'Periodontitis-defined-Alveolar Bone Loss', 'Periodontitis-base-Alveolar Bone Loss', 'Diabetes Mellitus-assessed-Cerebrovascular Disorders', 'Obesity Hypoventilation Syndrome-include-Pulmonary Disease, Chronic Obstructive', 'Pulmonary Disease, Chronic Obstructive-followed-Obesity Hypoventilation Syndrome', 'Arthritis, Rheumatoid-related-Death', 'Arthritis, Rheumatoid-observe-Death', 'Arthritis, Rheumatoid-contribute-Death', 'Thromboembolism-experience-Stroke', 'Sarcopenia-tend-Chronic Disease', 'Mitral Valve Stenosis-caused-Rheumatic Diseases', 'Mitral Valve Stenosis-compare-Rheumatic Diseases', 'Mitral Valve Stenosis-present-Rheumatic Diseases', 'Hypercholesterolemia-reported-Cerebral Infarction', 'Hypercholesterolemia-reported-Atrial Fibrillation', 'Atrial Fibrillation-diagnosed-Stroke', 'Hypertriglyceridemia-compare-Cerebral Infarction', 'Hypertriglyceridemia-reported-Cerebral Infarction', 'Hypertriglyceridemia-compare-Atrial Fibrillation', 'Hypertriglyceridemia-reported-Atrial Fibrillation', 'Coronary Artery Disease-observed-Cerebral Infarction', 'Death-observed-Cerebral Infarction', 'Mitochondrial Diseases-associated-Neoplasms', 'Neoplasms-associated-Mitochondrial Diseases', 'Neoplasms-inform-Death', 'Neoplasms-assess-Pain', 'Death-assess-Pain', 'Cellulitis-include-Infections', 'Arthritis-include-Infections', 'Peritoneal Neoplasms-include-Infections', 'Endocarditis-include-Infections', 'Vipoma-reveal-Polyps', 'HIV Infections-compare-Infections', 'HIV Infections-compare-Cardiovascular Diseases', 'HIV Infections-compare-Infant, Newborn, Diseases', 'HIV Infections-compare-Respiratory Tract Infections', 'HIV Infections-compare-Neoplasms', 'Infections-compare-Cardiovascular Diseases', 'Infections-compare-Infant, Newborn, Diseases', 'Infections-compare-Neoplasms', 'Cardiovascular Diseases-compare-Infant, Newborn, Diseases', 'Uterine Diseases-become-Muscular Disorders, Atrophic', 'Cardiovascular Diseases-compare-Respiratory Tract Infections', 'Cardiovascular Diseases-compare-Tuberculosis', 'Cardiovascular Diseases-compare-Neoplasms', 'Infant, Newborn, Diseases-compare-Respiratory Tract Infections', 'Infant, Newborn, Diseases-compare-Tuberculosis', 'Infant, Newborn, Diseases-compare-Neoplasms', 'Respiratory Tract Infections-compare-Tuberculosis', 'Respiratory Tract Infections-compare-Neoplasms', 'Tuberculosis-compare-Neoplasms', 'Death-measure-Heart Failure', 'Death-measure-Myocardial Infarction', 'Death-measure-Kidney Diseases', 'Death-measure-Neoplasms', 'Death-measure-Peripheral Vascular Diseases', 'Death-measure-Delirium', 'Tibial Meniscus Injuries-elect-Infections', 'Brain Injuries, Traumatic-related-Death', 'Brain Injuries, Traumatic-reduce-Death', 'Atherosclerosis-develop-Acute Coronary Syndrome', 'Inflammation-play-Rupture', 'Inflammation-activate-Thrombosis', 'Acute Coronary Syndrome-suffer-Anaphylaxis', 'Acute Coronary Syndrome-rule-Myocardial Infarction', 'Heart Failure-enhance-Dementia', 'Heart Failure-appear-Stroke', 'Coronary Artery Disease-enhance-Dementia', 'Coronary Artery Disease-appear-Stroke', 'Dementia-appear-Stroke', 'Hypertension-reduce-Stroke', 'Dementia-enhance-Heart Failure', 'Heart Failure-seem-Stroke', 'Dementia-enhance-Coronary Artery Disease', 'Coronary Artery Disease-seem-Stroke', 'Dementia-seem-Stroke', 'Delirium-defined-Death', 'Myoclonus-include-Dementia', 'Perceptual Disorders-include-Dementia', 'Cerebellar Ataxia-include-Dementia', 'Hypokinesia-include-Dementia', 'Language Disorders-occur-Creutzfeldt-Jakob Syndrome', 'Creutzfeldt-Jakob Syndrome-present-Genetic Diseases, Inborn', 'Ocular Hypertension-classified-Glaucoma', 'Inflammation-affected-Diabetes Mellitus', 'Arbovirus Infections-induce-Infections', 'Arbovirus Infections-restrict-Infections', 'Hallucinations-associated-Nervous System Diseases', 'Nervous System Diseases-associated-Hallucinations', 'Hallucinations-investigate-Anophthalmos', 'Hallucinations-investigate-Dementia', 'Hallucinations-investigate-Parkinson Disease', 'Atrial Fibrillation-defined-Mitral Valve Stenosis', 'Heart Valve Diseases-associated-Heart Failure', 'Heart Failure-associated-Heart Valve Diseases', 'Heart Valve Diseases-associated-Mitral Valve Stenosis', 'Mitral Valve Stenosis-associated-Heart Valve Diseases', 'Dementia-classified-Alzheimer Disease', 'Prostatic Neoplasms-defined-Neoplasms', 'Late Onset Disorders-observed-Guillain-Barre Syndrome', 'Tricuspid Valve Insufficiency-require-Atrioventricular Block', 'Osteoporosis-show-Fractures, Bone', 'Retinal Diseases-coexist-Cataract', 'Pain-compare-Brain Injuries, Traumatic', 'Chronic Pain-found-Hypesthesia', 'Death-include-Wounds and Injuries', 'Acute Kidney Injury-increased-Renal Insufficiency, Chronic', 'Acute Kidney Injury-increased-Diabetes Mellitus', 'Acute Kidney Injury-manage-Neoplasms', 'Kidney Diseases-related-Neoplasms', 'Neoplasm Invasiveness-used-Pneumococcal Infections', 'Substance-Related Disorders-correlated-Hypertension', 'Sarcopenia-occur-Wasting Syndrome', 'Thromboembolism-compare-Neutropenia', 'Thromboembolism-compare-Lymphopenia', 'Thromboembolism-compare-Thrombocytopenia', 'Purpura, Thrombotic Thrombocytopenic-show-Coronary Artery Disease', 'Purpura, Thrombotic Thrombocytopenic-show-Stroke', 'Mitochondrial Diseases-drive-Proteostasis Deficiencies', 'Proteostasis Deficiencies-considered-Neurodegenerative Diseases', 'Osteoarthritis-show-Osteosarcoma', 'Osteoarthritis-associated-Hip Dislocation, Congenital', 'Hip Dislocation, Congenital-associated-Osteoarthritis', 'HIV Infections-use-Chronic Disease', 'HIV Infections-live-Seizures', 'Hyperglycemia-increase-Kidney Diseases', 'Kidney Diseases-exposed-Diabetes Mellitus', 'HIV Infections-improve-Cardiovascular Diseases', 'Cerebral Hemorrhage-assess-Cerebral Amyloid Angiopathy', 'Cerebral Hemorrhage-classified-Cerebral Amyloid Angiopathy', 'Cerebral Amyloid Angiopathy-include-Cerebral Hemorrhage', 'Cerebral Hemorrhage-identify-Cerebral Amyloid Angiopathy', 'Cerebral Amyloid Angiopathy-predicted-Intracranial Hemorrhages', 'Tinnitus-accompany-Hearing Loss', 'Sleep Deprivation-rewire-Tinnitus', 'Siderosis-show-Seizures', 'Subarachnoid Hemorrhage-associated-Seizures', 'Seizures-associated-Subarachnoid Hemorrhage', 'Siderosis-associated-Seizures', 'Seizures-associated-Siderosis', 'Cerebral Hemorrhage-show-Cerebral Amyloid Angiopathy', 'Infections-complicated-Meningoencephalitis', 'Bacteremia-complicated-Meningoencephalitis', 'Meningoencephalitis-complicated-Fetal Diseases', 'Neoplasms-suffer-Infertility, Female', 'Neoplasms-occur-Ovarian Diseases', 'Death-prevent-Infections', 'Hypertension-investigate-Polycystic Ovary Syndrome', 'Genetic Diseases, Inborn-manifested-Immunologic Deficiency Syndromes', 'Lymphoma, B-Cell-complete-Drug-Related Side Effects and Adverse Reactions', 'Tooth Loss-measured-Trismus', 'Osteoarthritis-known-Pain', 'Osteoporosis-examine-Muscular Dystrophy, Duchenne', 'Hyperlipidemias-include-Cardiovascular Diseases', 'Metabolic Diseases-include-Cardiovascular Diseases', 'Wounds and Injuries-try-Death', 'Hip Fractures-equate-Fractures, Bone', 'Hypertension-use-Diabetes Mellitus', 'Dementia-consider-Neurodegenerative Diseases', 'Dementia-consider-Aneurysm', 'Seizures-investigate-Metabolic Syndrome', 'Sleep Initiation and Maintenance Disorders-include-Neurodegenerative Diseases', 'Hip Dislocation, Congenital-compare-Femoral Neck Fractures', 'Metabolic Syndrome-noted-Cardiovascular Abnormalities', 'Metabolic Diseases-associated-Mastocytosis, Systemic', 'Mastocytosis, Systemic-associated-Metabolic Diseases', 'Metabolic Diseases-result-Death', 'Malnutrition-studied-Cerebral Infarction', 'Malnutrition-studied-Hemorrhage', 'Death-studied-Cerebral Infarction', 'Death-studied-Hemorrhage', 'Malnutrition-associated-Stroke', 'Stroke-associated-Malnutrition', 'Malnutrition-associated-Hemorrhage', 'Hemorrhage-associated-Malnutrition', 'Infections-transmitted-Fever', 'Fever-transmitted-Cough', 'Fever-transmitted-Pharyngeal Diseases', 'Fever-transmitted-Dyspnea', 'Fever-transmitted-Fatigue', 'Diabetes Mellitus-screen-Eye Diseases', 'Hypertension-screen-Eye Diseases', 'Limb Deformities, Congenital-experience-Chronic Disease', 'Vascular Calcification-mediated-Death', 'Vascular Calcification-mediated-Renal Insufficiency, Chronic', 'Arthritis-cause-Joint Diseases', 'Neoplasms-exposed-Pain', 'Neoplasms-include-Pain', 'Peripheral Nervous System Diseases-associated-Neurotoxicity Syndromes', 'Neurotoxicity Syndromes-associated-Peripheral Nervous System Diseases', 'Peripheral Nervous System Diseases-associated-Nerve Degeneration', 'Nerve Degeneration-associated-Peripheral Nervous System Diseases', 'Peripheral Nervous System Diseases-result-Nerve Degeneration', 'Neurotoxicity Syndromes-result-Nerve Degeneration', 'Nervous System Diseases-include-Diabetes Mellitus', 'Peripheral Nervous System Diseases-include-Diabetes Mellitus', 'Schistosomiasis-known-Infections', 'Alzheimer Disease-become-Heredodegenerative Disorders, Nervous System', 'Schistosomiasis-maximize-Seizures', 'Aortic Diseases-associate-Leukoencephalopathies', 'Leukoencephalopathies-associate-Aortic Diseases', 'Death-infected-Infections', 'Dysbiosis-involved-Diabetes Mellitus', 'Dysbiosis-known-Diabetes Mellitus', 'Dysbiosis-involved-Inflammatory Bowel Diseases', 'Dysbiosis-known-Inflammatory Bowel Diseases', 'Dysbiosis-involved-Neoplasms', 'Dysbiosis-known-Neoplasms', 'Dysbiosis-involved-HIV Infections', 'Dysbiosis-known-HIV Infections', 'Dysbiosis-live-HIV Infections', 'Appendicitis-show-Death', 'Appendicitis-show-Appendiceal Neoplasms', 'Dysbiosis-related-Diabetes Mellitus', 'Diabetes Mellitus-control-Inflammation', 'Dysbiosis-control-Inflammation', 'Death-undergo-Wounds and Injuries', 'Deglutition Disorders-increase-Pneumonia, Aspiration', 'Alzheimer Disease-suffering-Glaucoma', 'Parkinson Disease-develop-Dementia', 'Osteoarthritis-contribute-Fractures, Bone', 'Osteoarthritis-affect-Death', 'Glossitis, Benign Migratory-occur-Lyme Disease', 'Edema-recognize-Heart Failure', 'Inflammatory Bowel Diseases-coupled-Inflammation', 'Inflammatory Bowel Diseases-control-Inflammation', 'Colorectal Neoplasms-recommended-Inflammatory Bowel Diseases', 'Inflammation-control-Colorectal Neoplasms', 'Colorectal Neoplasms-diagnosed-Inflammatory Bowel Diseases', 'Inflammation-predict-Neoplasms', 'Fractures, Open-associated-Alzheimer Disease', 'Alzheimer Disease-associated-Fractures, Open', 'Inflammation-involve-Diabetes Mellitus, Type 2', 'Diabetes Mellitus, Type 2-involve-Mitochondrial Diseases', 'Diabetes Mellitus, Type 2-associated-Mitochondrial Diseases', 'Mitochondrial Diseases-associated-Diabetes Mellitus, Type 2', 'Inflammation-involve-Diabetic Nephropathies', 'Diabetic Nephropathies-involve-Mitochondrial Diseases', 'Diabetic Nephropathies-associated-Mitochondrial Diseases', 'Mitochondrial Diseases-associated-Diabetic Nephropathies', 'Inflammation-associated-Mitochondrial Diseases', 'Mitochondrial Diseases-associated-Inflammation', 'Headache Disorders, Secondary-related-Giant Cell Arteritis', 'Delirium-related-Giant Cell Arteritis', 'Hallucinations-related-Giant Cell Arteritis', 'Dementia-appear-Headache Disorders, Secondary', 'Dementia-appear-Memory Disorders', 'Myotonic Dystrophy-associated-Hypertension', 'Hypertension-associated-Myotonic Dystrophy', 'Myotonic Dystrophy-associated-Myocardial Infarction', 'Myocardial Infarction-associated-Myotonic Dystrophy', 'Myotonic Dystrophy-associated-Renal Insufficiency, Chronic', 'Renal Insufficiency, Chronic-associated-Myotonic Dystrophy', 'Arthritis, Rheumatoid-undergo-Tenosynovitis', 'Arthritis, Rheumatoid-undergo-Bursitis', 'Arthritis, Rheumatoid-undergo-Synovitis', 'Polymyalgia Rheumatica-include-Arthritis, Rheumatoid', 'Polymyalgia Rheumatica-include-Spondylitis, Ankylosing', 'Inflammation-contribute-Neoplasms', 'Neoplasms-modulate-Inflammation', 'Inflammation-recognized-Chronic Disease', 'Inflammation-serve-Cardiovascular Diseases', 'Inflammation-explore-Diabetes Mellitus', 'Inflammation-explore-Alzheimer Disease', 'Paralysis-observed-Seizures', 'Paralysis-observed-Epilepsy, Tonic-Clonic', 'Paralysis-characterized-Muscle Weakness', 'Epilepsy-associate-Stroke', 'Stroke-associate-Epilepsy', 'Paralysis-characterized-Hemiplegia', 'Muscle Weakness-diagnose-Paralysis', 'Paralysis-occur-Seizures', 'Nervous System Diseases-characterized-Muscle Weakness', 'Nervous System Diseases-characterized-Hemiplegia', 'Hemiplegia-diagnose-Paralysis', 'Nervous System Diseases-follow-Seizures', 'Muscle Weakness-follow-Seizures', 'Muscle Weakness-characterized-Seizures', 'Cerebral Infarction-experience-Paralysis', 'Hemiplegia-follow-Seizures', 'Hemiplegia-characterized-Seizures', 'Paralysis-experience-Epilepsy', 'Seizures-depend-Myopathies, Structural, Congenital', 'Paralysis-distinguish-Muscle Weakness', 'Paralysis-improve-Muscle Weakness', 'Death-estimate-Hepatitis C', 'Ankle Fractures-identify-Fractures, Bone', 'Kidney Diseases-encountered-Neoplasms', 'Carcinoma, Squamous Cell-comprise-Skin Neoplasms', 'Dysbiosis-become-Hypertension', 'Dysbiosis-become-Dementia', 'Death-increase-Infections', 'Alzheimer Disease-exhibit-Gait Disorders, Neurologic', 'Hypertension-characterize-Dementia', 'Hypertension-suffer-Alzheimer Disease', 'Thoracic Outlet Syndrome-characterize-Dementia', 'Thoracic Outlet Syndrome-suffer-Alzheimer Disease', 'Cerebral Amyloid Angiopathy-contribute-Cerebral Infarction', 'Cerebral Amyloid Angiopathy-contribute-Hemorrhage', 'Hemorrhage-prevent-Venous Thromboembolism', 'Pneumonia-observed-Pulmonary Disease, Chronic Obstructive', 'Hematuria-associated-Hypertension', 'Hypertension-associated-Hematuria', 'Inflammation-exert-Osteoporosis', 'Infections-include-Genetic Diseases, Inborn', 'Hypertension-associated-Eye Infections, Fungal', 'Eye Infections, Fungal-associated-Hypertension', 'Diabetes Mellitus-associated-Eye Infections, Fungal', 'Eye Infections, Fungal-associated-Diabetes Mellitus', 'Diabetic Neuropathies-associated-Eye Infections, Fungal', 'Eye Infections, Fungal-associated-Diabetic Neuropathies', 'Diabetic Nephropathies-associated-Eye Infections, Fungal', 'Eye Infections, Fungal-associated-Diabetic Nephropathies', 'Diabetic Foot-associated-Eye Infections, Fungal', 'Eye Infections, Fungal-associated-Diabetic Foot', 'Hypotension-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-Hypotension', 'Hypotension-associated-Eye Infections, Fungal', 'Eye Infections, Fungal-associated-Hypotension', 'Headache-followed-Muscle Weakness', 'Biliary Tract Diseases-tend-Infections', 'Biliary Tract Diseases-tend-Death', 'Death-caused-Bacteremia', 'Sarcopenia-demonstrate-Fractures, Bone', 'Epilepsy-characterised-Seizures', 'Urinary Retention-managed-Infections', 'Alzheimer Disease-recapitulate-Blood Protein Disorders', 'Alzheimer Disease-recapitulate-Neurodegenerative Diseases', 'Wounds and Injuries-related-Death', 'Pneumonia-associated-Thoracic Injuries', 'Thoracic Injuries-associated-Pneumonia', 'Leukoencephalopathies-associated-Atrial Fibrillation', 'Atrial Fibrillation-associated-Leukoencephalopathies', 'Atrial Fibrillation-monitor-Cerebral Hemorrhage', 'Sleep Apnea, Obstructive-regarded-Brain Injuries, Traumatic', 'Sleep Initiation and Maintenance Disorders-regarded-Brain Injuries, Traumatic', 'Sleep Apnea, Obstructive-correlated-Brain Injuries, Traumatic', 'Sleep Initiation and Maintenance Disorders-correlated-Brain Injuries, Traumatic', 'Pain-correlated-Sleep Wake Disorders', 'Sleep Wake Disorders-follow-Brain Injuries, Traumatic', 'Acute Coronary Syndrome-fit-Seizures', 'Infections-resolve-Inflammation', 'Pneumonia-needed-Dementia', 'Primary Myelofibrosis-occur-Polycythemia Vera', 'Primary Myelofibrosis-occur-Thrombocythemia, Essential', 'Primary Myelofibrosis-shorten-Thrombocythemia, Essential', 'Carcinogenesis-induced-Inflammation', 'Heart Rupture-contribute-Hydrocephalus', 'Oculocerebrorenal Syndrome-predict-Alzheimer Disease', 'Dermatitis, Atopic-associated-Infections', 'Infections-associated-Dermatitis, Atopic', 'Dermatitis, Atopic-associated-Pruritus', 'Pruritus-associated-Dermatitis, Atopic', 'Dermatitis, Atopic-associated-Pain', 'Pain-associated-Dermatitis, Atopic', 'Alzheimer Disease-characterized-Immunologic Deficiency Syndromes', 'Neurodegenerative Diseases-characterized-Immunologic Deficiency Syndromes', 'Growth Disorders-characterized-Epilepsy, Complex Partial', 'Autoimmune Diseases-occur-Genetic Diseases, Inborn', 'X-Linked Combined Immunodeficiency Diseases-cause-Agammaglobulinemia', 'Hypergammaglobulinemia-accompanied-Job Syndrome', 'Brain Injuries, Traumatic-result-Inflammation', 'Brain Injuries, Traumatic-result-Dementia', 'Glaucoma-show-Nervous System Diseases', 'Uveitis, Anterior-present-Glaucoma', 'Neoplasms-associated-Postoperative Cognitive Complications', 'Postoperative Cognitive Complications-associated-Neoplasms', 'Anemia-associated-Postoperative Cognitive Complications', 'Postoperative Cognitive Complications-associated-Anemia', 'Anemia-increase-Postoperative Cognitive Complications', 'Anemia-increase-Neoplasms', 'Upper Extremity Deformities, Congenital-influence-Death', 'Death-calculated-Hip Fractures', 'Sarcopenia-reflect-Parkinsonian Disorders', 'Neurodegenerative Diseases-reflect-Parkinsonian Disorders', 'Parkinson Disease-lead-Sarcopenia', 'Neurodegenerative Diseases-lead-Sarcopenia', 'HIV Infections-result-Cardiovascular Diseases', 'Vision Disorders-associated-Atrophy', 'Atrophy-associated-Vision Disorders', 'Osteoporosis-affect-Chronic Disease', 'Infections-cause-End Stage Liver Disease', 'Peripheral Arterial Disease-observe-Death', 'Alzheimer Disease-considered-Neurodegenerative Diseases', 'End Stage Liver Disease-reduce-Death', 'Atrial Fibrillation-diagnosed-Death', 'Sarcopenia-recognized-HIV Infections', 'Bone Neoplasms-induced-Hereditary Angioedema Type III', 'Breast Neoplasms-compare-Neoplasms', 'Atherosclerosis-accelerate-Inflammation', 'Heart Failure-noted-Wounds and Injuries', 'Neoplasms-outcompet-Stomach Neoplasms', 'Neoplasms-associated-Memory Disorders', 'Memory Disorders-associated-Neoplasms', 'Weight Gain-contribute-HIV Infections', 'Death-present-Respiratory Insufficiency', 'Death-present-Shock', 'Death-driven-Inflammation', 'Hypertension-found-Obesity', 'Critical Illness-mitigate-Seizures', 'Heredodegenerative Disorders, Nervous System-target-Brain Diseases', 'Cardiovascular Diseases-follow-Death', 'Stroke-consider-Heart Valve Diseases', 'Atrial Fibrillation-require-Heart Valve Diseases', 'Fibrosis-modify-Hepatitis C', 'Heart Failure-modify-Hepatitis C', 'Cardiovascular Diseases-outweigh-Neoplasms', 'Neoplasms-identified-Death', 'Diabetes Mellitus-show-Neoplasms', 'Proteinuria-classified-Kidney Diseases', 'Albuminuria-classified-Kidney Diseases', 'Coronary Artery Disease-increased-Dementia', 'Neurologic Manifestations-associated-Drug-Related Side Effects and Adverse Reactions', 'Drug-Related Side Effects and Adverse Reactions-associated-Neurologic Manifestations', 'Neurologic Manifestations-present-Stroke', 'Drug-Related Side Effects and Adverse Reactions-present-Stroke', 'Seizures-show-Stroke', 'Kidney Diseases-exacerbate-Hypertension', 'Hip Dislocation, Congenital-improve-Infections', 'Death-calculated-Hypotrichosis', 'Hypotrichosis-defined-Death', 'Chronic Pain-considered-Fibromyalgia', 'Myelodysplastic Syndromes-explain-Adrenal Insufficiency', 'Headache Disorders, Secondary-associated-Death', 'Death-associated-Headache Disorders, Secondary', 'Myelodysplastic Syndromes-promote-Inflammation', 'Pain-describe-Delirium', 'Pain-describe-Movement Disorders', 'Drug Overdose-spared-Parkinson Disease', 'Infections-include-Liver Diseases', 'Malaria-include-Liver Diseases', 'Wounds and Injuries-increase-Cardiac Output, Low', 'Fatigue-lead-Sleep Initiation and Maintenance Disorders', 'Epilepsy-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-Epilepsy', 'Stroke-associated-Obesity', 'Obesity-associated-Stroke', 'Epilepsy-associated-Obesity', 'Obesity-associated-Epilepsy', 'Cardiac Output, Low-prevent-Arthritis', 'Sclerosis-include-Autoimmune Diseases', 'Death-mitigated-HIV Infections', 'Death-improve-HIV Infections', 'Pain-related-Infections', 'Cataract-suggest-Inflammation', 'Esophageal Squamous Cell Carcinoma-receive-Neoplasms', 'Dysbiosis-involved-Colitis', 'Hypotension, Orthostatic-associated-Atrial Fibrillation', 'Atrial Fibrillation-associated-Hypotension, Orthostatic', 'Atrial Fibrillation-pertain-Death', 'Inflammation-implicated-Neurodegenerative Diseases', 'Progeria-harbor-Cardiovascular Diseases', 'Progeria-harbor-Joint Diseases', 'Progeria-target-Inflammation', 'Parkinson Disease-depicted-Pain', 'Parkinson Disease-depicted-Olfaction Disorders', 'Parkinson Disease-result-Death', 'Parkinson Disease-characterized-Dyskinesia, Drug-Induced', 'Neurodegenerative Diseases-result-Death', 'Neurodegenerative Diseases-result-Movement Disorders', 'Neurodegenerative Diseases-result-Dyskinesia, Drug-Induced', 'Neurodegenerative Diseases-characterized-Dyskinesia, Drug-Induced', 'Cerebral Arterial Diseases-considered-Leukoaraiosis', 'Neurodegenerative Diseases-result-Hypokinesia', 'Neurodegenerative Diseases-result-Muscle Rigidity', 'Neurodegenerative Diseases-result-Tremor', 'Death-result-Movement Disorders', 'Death-result-Dyskinesia, Drug-Induced', 'Death-result-Hypokinesia', 'Death-result-Muscle Rigidity', 'Movement Disorders-characterized-Dyskinesia, Drug-Induced', 'Movement Disorders-characterized-Hypokinesia', 'Movement Disorders-characterized-Muscle Rigidity', 'Movement Disorders-characterized-Tremor', 'Tremor-include-Nervous System Diseases', 'Neoplasms-detect-Sarcopenia', 'Inflammation-hasten-Chronic Disease', 'Neoplasms-place-Carcinogenesis', 'Seizures-place-Carcinogenesis', 'Pain-found-Sleep Wake Disorders', 'Pain-cause-Sleep Wake Disorders', 'Alzheimer Disease-involve-Atrophy', 'Hypertrophy-include-Ventricular Remodeling', 'Fibrosis-include-Ventricular Remodeling', 'Ventricular Remodeling-include-Hypertension', 'Ventricular Remodeling-lead-Hypertension', 'Hypertrophy-lead-Hypertension', 'Fibrosis-lead-Hypertension', 'Intervertebral Disc Degeneration-associate-Constriction, Pathologic', 'Constriction, Pathologic-associate-Intervertebral Disc Degeneration', 'Back Pain-present-Spinal Stenosis', 'Pain-tell-Death', 'Fractures, Bone-vary-Upper Extremity Deformities, Congenital', 'Fractures, Bone-occur-Death', 'Death-observed-Femoral Fractures', 'HIV Infections-impact-Cardiovascular Diseases', 'Neurodegenerative Diseases-progress-Parkinson Disease', 'Drug-Related Side Effects and Adverse Reactions-lead-Death', 'Drug-Related Side Effects and Adverse Reactions-lead-Cardiovascular Diseases', 'Hip Fractures-assess-Dementia', 'Diabetes Mellitus-use-Hyperglycemia', 'Obesity-use-Hyperglycemia', 'Skin Diseases-treat-Dermatitis', 'Skin Diseases-treat-Acne Vulgaris', 'Skin Diseases-treat-Eczema', 'Neoplasms-known-Skin Neoplasms', 'Growth Disorders-identified-Death, Sudden, Cardiac', 'Death-mitigate-Rubella', 'Dementia-include-Dementia, Vascular', 'Neoplasms-present-Pain', 'Neoplasms-present-Nausea', 'Neoplasms-distress-Vomiting', 'Neoplasms-distress-Fatigue', 'Graft vs Host Disease-report-Pain', 'Neoplasms-unexamined-Dementia', 'Neoplasms-maintain-Death', 'Atrial Fibrillation-lead-Thromboembolism', 'Atrial Fibrillation-lead-Heart Failure', 'Arrhythmias, Cardiac-lead-Thromboembolism', 'Arrhythmias, Cardiac-lead-Heart Failure', 'Drug-Related Side Effects and Adverse Reactions-include-Cardiomyopathies', 'Drug-Related Side Effects and Adverse Reactions-include-Atrial Fibrillation', 'Cardiomyopathies-lead-Atrial Fibrillation', 'Metabolic Syndrome-lead-Atrial Fibrillation', 'Cardiomyopathies-related-Metabolic Syndrome', 'Infections-occur-Inflammatory Bowel Diseases', 'Neoplasms-occur-Inflammatory Bowel Diseases', 'Heart Failure-occur-Inflammatory Bowel Diseases', 'Critical Illness-remain-Opportunistic Infections', 'Critical Illness-remain-Pulmonary Disease, Chronic Obstructive', 'Critical Illness-remain-Atherosclerosis', 'Critical Illness-remain-Acquired Immunodeficiency Syndrome', 'Thrombosis-experience-Pulmonary Embolism', 'Delirium-diagnosed-Erythema Infectiosum', 'Dementia-reveal-Delirium', 'Lymphoma-include-Lymphomatoid Papulosis', 'Lymphoma, Primary Cutaneous Anaplastic Large Cell-include-Lymphomatoid Papulosis', 'Lymphoproliferative Disorders-include-Lymphomatoid Papulosis', 'Meningeal Neoplasms-associated-Cardiomegaly', 'Cardiomegaly-associated-Meningeal Neoplasms', 'Arbovirus Infections-modulate-Inflammation', 'Death-evaluate-Fractures, Bone', 'Peripheral Nervous System Diseases-include-Nervous System Diseases', 'Diabetes Mellitus-include-Nervous System Diseases', 'Substance-Related Disorders-associated-Kidney Diseases', 'Kidney Diseases-associated-Substance-Related Disorders', 'Drug-Related Side Effects and Adverse Reactions-improve-Neoplasms', 'Pain-replace-Neuralgia', 'Diabetes Mellitus-included-Hypoglycemia', 'Diabetes Mellitus-determine-Hypoglycemia', 'Dementia, Vascular-reduced-Stroke', 'Sarcopenia-allocated-Obesity, Abdominal', 'Sarcopenia-allocated-Abnormalities, Drug-Induced', 'Malnutrition-identify-Neoplasms', 'Memory Disorders-occur-Dementia', 'Death-compare-Acute Kidney Injury', 'Acute Kidney Injury-stage-Kidney Diseases', 'Osteoporosis-receive-Breast Neoplasms', 'Osteoporosis-receive-Prostatic Neoplasms', 'Death-include-Respiratory Tract Infections', 'Death-reduced-Infections', 'Infections-include-Death', 'Death-equal-Infections', 'Uveitis-noted-Panuveitis', 'Immunologic Deficiency Syndromes-display-Hypertension', 'Cardiomyopathies-expose-Kidney Diseases', 'Anemia-increase-Hip Fractures', 'Anemia-indicate-Hip Fractures', 'Menorrhagia-prescribe-Breast Neoplasms', 'Menorrhagia-balanced-Obesity', 'Polycystic Ovary Syndrome-outline-Cardiovascular Diseases', 'Neurologic Manifestations-outline-Cardiovascular Diseases', 'Muscle Weakness-impair-Sarcopenia', 'Muscular Diseases-impair-Sarcopenia', 'Metabolic Syndrome-associated-AIDS Arteritis, Central Nervous System', 'AIDS Arteritis, Central Nervous System-associated-Metabolic Syndrome', 'Heart Failure-associate-HIV Infections', 'HIV Infections-associate-Heart Failure', 'Heart Failure-become-Inflammation', 'HIV Infections-associate-Inflammation', 'Inflammation-associate-HIV Infections', 'Heart Failure-include-Cardiomyopathies', 'HIV Infections-include-Cardiomyopathies', 'Atrial Fibrillation-pose-Thromboembolism', 'Atrial Fibrillation-pose-Stroke', 'Atrial Fibrillation-pose-Heart Failure', 'Atrial Fibrillation-pose-Myocardial Infarction', 'Cardiovascular Diseases-calculated-Death', 'Pruritus-downgrade-Sleep Wake Disorders', 'Cardiomyopathies-reduce-Cardiomegaly', 'Death-investigate-Renal Insufficiency, Chronic', 'Death-investigate-Kidney Failure, Chronic', 'Inflammatory Bowel Diseases-demonstrate-Infections', 'Delirium-mitigate-Brain Injuries', 'Delirium-associated-Critical Illness', 'Critical Illness-associated-Delirium', 'Brain Injuries-associated-Critical Illness', 'Critical Illness-associated-Brain Injuries', 'Granulomatosis with Polyangiitis-defined-Inflammation', 'Granulomatosis with Polyangiitis-defined-Vasculitis', 'Inflammation-involve-Vasculitis', 'Inflammation-necrotize-Vasculitis', 'Esotropia-found-Exotropia', 'Osteoporosis-detected-Fractures, Bone', 'Death-increased-Giant Cell Arteritis', 'Glucose Metabolism Disorders-undergo-Prostatic Hyperplasia', 'Calcinosis-contribute-Cardiovascular Diseases', 'Calcinosis-contribute-Cardiomyopathy, Hypertrophic', 'Calcinosis-contribute-Hypertension', 'Calcinosis-contribute-Renal Insufficiency, Chronic', 'Calcinosis-contribute-Diabetes Mellitus', 'Cardiomyopathy, Hypertrophic-include-Cardiovascular Diseases', 'Hypoxia-affect-Retinal Diseases', 'Huntington Disease-seem-Alcoholism', 'Deglutition Disorders-associated-Malnutrition', 'Malnutrition-associated-Deglutition Disorders', 'Arthralgia-modify-Osteoarthritis', 'Hyperopia-identified-Glycogen Storage Disease Type II', 'Wounds and Injuries-result-Hip Fractures', 'Parental Death-associated-Myopia', 'Myopia-associated-Parental Death', 'Heart Arrest-recognized-Idiopathic Pulmonary Fibrosis', 'Diabetes Mellitus-seem-Cardiovascular Diseases', 'Alzheimer Disease-exclude-Hearing Loss', 'Hematoma, Subdural, Chronic-associated-Craniocerebral Trauma', 'Craniocerebral Trauma-associated-Hematoma, Subdural, Chronic', 'Dementia-hear-Hearing Loss', 'Hypertension-concentrate-Cardiovascular Diseases', 'Hypertension-focus-Heart Failure', 'Respiratory Tract Diseases-undergo-Motor Neuron Disease', 'Neoplasms-identify-Urinary Bladder Neoplasms', 'Hereditary Breast and Ovarian Cancer Syndrome-related-Hematoma, Subdural', 'Hereditary Breast and Ovarian Cancer Syndrome-observed-Brain Injuries, Traumatic', 'Inflammation-characterized-Death', 'Inflammation-characterized-Communicable Diseases', 'Arthritis, Rheumatoid-contribute-Communicable Diseases', 'Neoplasms-report-Fatigue', 'Neoplasms-report-Myalgia', 'Aneurysm-include-Diabetic Nephropathies', 'Aneurysm-include-Peripheral Nervous System Diseases', 'Pancreatitis-considered-Diabetic Angiopathies', 'Fibrosis-lead-Cerebrovascular Disorders', 'Fibrosis-result-Inflammation', 'Sleep Deprivation-hypothesized-Inflammation', 'Sleep Deprivation-hypothesized-Alzheimer Disease', 'Sleep Deprivation-hypothesized-Cardiovascular Diseases', 'Immunologic Deficiency Syndromes-contribute-Cardiomyopathies', 'Infections-found-Glioma', 'Fractures, Bone-removed-Pain', 'Fractures, Bone-compromise-Patellofemoral Pain Syndrome', 'Atherosclerosis-account-Death', 'Muscle Weakness-differentiated-Fatigue', 'Muscle Weakness-differentiated-Pain', 'Sarcopenia-present-Muscle Weakness', 'Osteosarcoma-encouraged-Neoplasms', 'Neoplasm Metastasis-encouraged-Neoplasms', 'Neoplasms-correlated-Neoplasm Metastasis', 'Acromegaly-result-Pituitary Neoplasms', 'Communicable Diseases-result-Pituitary Neoplasms', 'Cataract-considered-Ocular Hypertension', 'Inflammatory Bowel Diseases-characterized-Colonic Diseases', 'Diabetes Mellitus-decrease-Chronic Disease', 'Diabetes Mellitus-belong-Death', 'Diabetes Mellitus-informed-Cataract', 'Diabetes Mellitus-increase-Cataract', 'Headache Disorders-occur-Seizures', 'Headache Disorders-occur-Hydrocephalus', 'Vulvovaginitis-result-Xerostomia', 'Vulvovaginitis-result-Dyspareunia', 'Heart Failure-demonstrate-Cardiac Output, Low', 'Dementia-show-Parkinson Disease', 'Dementia-show-Huntington Disease', 'Dementia-show-Amyotrophic Lateral Sclerosis', 'Neoplasms-show-Inflammation', 'Ulcer-show-Inflammation', 'Neoplasms-develop-Intestinal Obstruction', 'Cardiomyopathies-include-Diabetes Mellitus', 'Heart Diseases-include-Diabetes Mellitus', 'Pericarditis-include-Diabetes Mellitus', 'Cardiomyopathies-include-Hypertension', 'Heart Diseases-include-Hypertension', 'Stroke-constitute-Atrial Fibrillation', 'Pericarditis-include-Hypertension', 'Cardiomyopathies-include-Cardiovascular Diseases', 'Heart Diseases-include-Cardiovascular Diseases', 'Pericarditis-include-Cardiovascular Diseases', 'Cardiomyopathies-include-Aneurysm', 'Heart Diseases-include-Aneurysm', 'Heart Failure-include-Aneurysm', 'Pericarditis-include-Aneurysm', 'Neurodegenerative Diseases-explore-Respiratory Distress Syndrome', 'Neurodegenerative Diseases-explore-Obesity', 'Cerebrovascular Disorders-compare-Dementia, Vascular', 'Ovarian Diseases-become-Infertility, Female', 'Renal Insufficiency, Chronic-include-Death', 'Peripheral Arterial Disease-include-Death', 'Periodontal Diseases-lead-Periodontitis', 'Periodontal Diseases-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-Periodontal Diseases', 'Periodontal Diseases-associated-Arthritis', 'Arthritis-associated-Periodontal Diseases', 'Periodontal Diseases-associated-Arthritis, Rheumatoid', 'Arthritis, Rheumatoid-associated-Periodontal Diseases', 'Delirium-contribute-Psychomotor Agitation', 'Critical Illness-assess-Sepsis', 'Critical Illness-determine-Death', 'Diabetes Mellitus-associated-Renal Insufficiency', 'Renal Insufficiency-associated-Diabetes Mellitus', 'Seizures-result-Drug-Related Side Effects and Adverse Reactions', 'Alzheimer Disease-integrated-Macular Degeneration', 'Macular Degeneration-integrated-Diffuse Neurofibrillary Tangles with Calcification', 'Inflammation-linked-Mastocytosis, Systemic', 'Epidermal Cyst-cause-Inflammation', 'Sleep Wake Disorders-contribute-Hypogonadism', 'Lung Injury-prevent-Bronchopulmonary Dysplasia', 'Tuberculosis-develop-Neoplasms', 'Fractures, Bone-used-Osteoporosis', 'Pituitary Neoplasms-represent-Neoplasms', 'Neoplasms-represent-Pituitary Neoplasms', 'Genetic Diseases, Inborn-confer-Pituitary Neoplasms', 'Genetic Diseases, Inborn-considered-Neoplasms', 'Pituitary Neoplasms-considered-Neoplasms', 'Sarcopenia-suffer-Hip Fractures', 'Neurodegenerative Diseases-lead-Gliosis', 'Dementia-include-Heredodegenerative Disorders, Nervous System', 'Stroke-associated-Postoperative Cognitive Complications', 'Postoperative Cognitive Complications-associated-Stroke', 'Obesity-decrease-Hypertension', 'Alzheimer Disease-affect-Gliosis', 'Hyperuricemia-treat-Sleep Apnea Syndromes', 'Inflammation-result-Lens Diseases', 'Uveitis-associated-Cataract', 'Cataract-associated-Uveitis', 'Death-assess-Chronic Disease', 'Chronic Kidney Disease-Mineral and Bone Disorder-rise-Hypertension', 'Chronic Kidney Disease-Mineral and Bone Disorder-rise-Metabolic Syndrome', 'Chronic Kidney Disease-Mineral and Bone Disorder-rise-Obesity', 'Chronic Kidney Disease-Mineral and Bone Disorder-rise-Diabetes Mellitus, Type 2', 'Chronic Kidney Disease-Mineral and Bone Disorder-seek-Fatty Liver', 'Chronic Kidney Disease-Mineral and Bone Disorder-seek-Non-alcoholic Fatty Liver Disease', 'Corneal Diseases-differ-Glaucoma', 'Corneal Diseases-differ-Ocular Hypertension', 'Corneal Diseases-differ-Glaucoma, Open-Angle', 'Corneal Diseases-differ-Hypertension', 'Glaucoma-differ-Ocular Hypertension', 'Glaucoma-differ-Hypertension', 'Ocular Hypertension-shown-Glaucoma', 'Low Back Pain-obtain-Intervertebral Disc Degeneration', 'Death-defined-Leukemia, Myeloid, Acute', 'Myocardial Infarction-identified-Death', 'Myocardial Infarction-include-Thromboembolism', 'Death-include-Thromboembolism', 'Atrial Fibrillation-associate-Cerebral Infarction', 'Cerebral Infarction-associate-Atrial Fibrillation', 'Atrial Fibrillation-associate-Ischemia', 'Ischemia-associate-Atrial Fibrillation', 'Atrial Fibrillation-associate-Cerebral Small Vessel Diseases', 'Cerebral Small Vessel Diseases-associate-Atrial Fibrillation', 'Atrial Fibrillation-associate-Neurodegenerative Diseases', 'Neurodegenerative Diseases-associate-Atrial Fibrillation', 'Cerebral Infarction-associate-Cerebral Small Vessel Diseases', 'Cerebral Small Vessel Diseases-associate-Cerebral Infarction', 'Cerebral Infarction-associate-Neurodegenerative Diseases', 'Neurodegenerative Diseases-associate-Cerebral Infarction', 'Ischemia-associate-Cerebral Small Vessel Diseases', 'Cerebral Small Vessel Diseases-associate-Ischemia', 'Ischemia-imaging-Cerebral Small Vessel Diseases', 'Ischemia-associate-Neurodegenerative Diseases', 'Neurodegenerative Diseases-associate-Ischemia', 'Abnormalities, Drug-Induced-obtain-Pain', 'Rupture-precipitate-Cardiovascular Diseases', 'Osteoarthritis-manifested-Bone Cysts', 'Osteoarthritis-manifested-Synovitis', 'Osteoarthritis-result-Arthralgia', 'Neurodegenerative Diseases-manifested-Bone Cysts', 'Neurodegenerative Diseases-manifested-Synovitis', 'Neurodegenerative Diseases-result-Arthralgia', 'Bone Cysts-result-Arthralgia', 'Alzheimer Disease-display-Nerve Degeneration', 'Nerve Degeneration-provoke-Alzheimer Disease', 'Alzheimer Disease-provoke-Cardiovascular Diseases', 'Alzheimer Disease-provoke-Heart Failure, Diastolic', 'Heart Diseases-deteriorate-Dementia, Vascular', 'Heart Diseases-deteriorate-Alzheimer Disease', 'Precursor Cell Lymphoblastic Leukemia-Lymphoma-include-Hematologic Neoplasms', 'Leukemia-include-Hematologic Neoplasms', 'Leukemia, Erythroblastic, Acute-include-Hematologic Neoplasms', 'Multiple Myeloma-include-Hematologic Neoplasms', 'Heart Diseases-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-Heart Diseases', 'Diabetes Mellitus-prevent-Heart Diseases', 'Dirofilariasis-include-Vector Borne Diseases', 'Lyme Disease-include-Vector Borne Diseases', 'Anaplasmosis-include-Vector Borne Diseases', 'Muscle Weakness-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-Muscle Weakness', 'Hypertension-shared-Cardiovascular Diseases', 'Diabetes Mellitus-shared-Cardiovascular Diseases', 'Obesity-shared-Cardiovascular Diseases', 'Xerostomia-associated-Anemia, Iron-Deficiency', 'Anemia, Iron-Deficiency-associated-Xerostomia', 'Anemia-associated-Anemia, Iron-Deficiency', 'Anemia, Iron-Deficiency-associated-Anemia', 'Anemia, Iron-Deficiency-associated-Intestinal Polyposis', 'Intestinal Polyposis-associated-Anemia, Iron-Deficiency', 'Anemia, Iron-Deficiency-associated-Stomach Neoplasms', 'Stomach Neoplasms-associated-Anemia, Iron-Deficiency', 'Anemia, Iron-Deficiency-associated-Obesity', 'Obesity-associated-Anemia, Iron-Deficiency', 'Anemia, Iron-Deficiency-associated-Gastritis', 'Gastritis-associated-Anemia, Iron-Deficiency', 'Anemia, Iron-Deficiency-associated-Peptic Ulcer', 'Peptic Ulcer-associated-Anemia, Iron-Deficiency', 'Anemia, Iron-Deficiency-associated-Esophageal Neoplasms', 'Esophageal Neoplasms-associated-Anemia, Iron-Deficiency', 'Anemia, Iron-Deficiency-associated-Crohn Disease', 'Crohn Disease-associated-Anemia, Iron-Deficiency', 'Anemia, Iron-Deficiency-associated-Celiac Disease', 'Celiac Disease-associated-Anemia, Iron-Deficiency', 'Deglutition Disorders-recognized-Pneumonia', 'Malnutrition-recognized-Pneumonia', 'Anemia, Iron-Deficiency-associated-Lymphangiectasis', 'Lymphangiectasis-associated-Anemia, Iron-Deficiency', 'Dehydration-recognized-Pneumonia', 'Infections-prevent-Pneumonia', 'Death-prevent-Pneumonia', 'Atherosclerosis-exacerbate-Cardiovascular Diseases', 'Heart Diseases-exacerbate-Cardiovascular Diseases', 'Diabetes Mellitus-diagnosed-Dementia', 'Stroke-aggravate-Ischemic Attack, Transient', 'Death-aggravate-Ischemic Attack, Transient', 'Ischemic Attack, Transient-induced-Ischemia', 'Stroke-exert-Ischemic Attack, Transient', 'Brain Infarction-recover-Neurologic Manifestations', 'Edema-recover-Neurologic Manifestations', 'Dyslipidemias-associate-Infertility, Female', 'Infertility, Female-associate-Dyslipidemias', 'Dementia-impact-Heredodegenerative Disorders, Nervous System', 'Dementia-impact-Diabetes Mellitus', 'Dementia-impact-Alzheimer Disease', 'Diabetes Mellitus-include-Heredodegenerative Disorders, Nervous System', 'Inflammation-accompany-Metabolic Diseases', 'Alzheimer Disease-associated-Heredodegenerative Disorders, Nervous System', 'Heredodegenerative Disorders, Nervous System-associated-Alzheimer Disease', 'Pulmonary Disease, Chronic Obstructive-accompany-Diabetes Mellitus', 'Dementia-appear-Hip Fractures', 'Coronary Artery Disease-appear-Fractures, Bone', 'Cerebrovascular Disorders-appear-Hip Fractures', 'Myocardial Infarction-identified-Dementia', 'Pneumonia-appear-Hip Fractures', 'Myocardial Infarction-identified-Pneumonia', 'Myocardial Infarction-identified-Neoplasms', 'Myocardial Infarction-identified-Arthritis, Rheumatoid', 'Hypertension-identified-Dementia', 'Hypertension-identified-Pneumonia', 'Hypertension-identified-Neoplasms', 'Hypertension-identified-Arthritis, Rheumatoid', 'Dyslipidemias-identified-Dementia', 'Dyslipidemias-identified-Pneumonia', 'Dyslipidemias-identified-Neoplasms', 'Dyslipidemias-identified-Arthritis, Rheumatoid', 'Diabetes Mellitus-identified-Dementia', 'Dementia-reside-Death', 'Diabetes Mellitus-identified-Pneumonia', 'Diabetes Mellitus-identified-Neoplasms', 'Diabetes Mellitus-identified-Arthritis, Rheumatoid', 'Heart Failure-identified-Dementia', 'Heart Failure-identified-Pneumonia', 'Heart Failure-identified-Neoplasms', 'Heart Failure-identified-Arthritis, Rheumatoid', 'Plaque, Atherosclerotic-break-Rupture', 'Arrhythmias, Cardiac-identified-Dementia', 'Arrhythmias, Cardiac-identified-Pneumonia', 'Arrhythmias, Cardiac-identified-Neoplasms', 'Arrhythmias, Cardiac-identified-Arthritis, Rheumatoid', 'Renal Insufficiency-identified-Dementia', 'Renal Insufficiency-identified-Pneumonia', 'Renal Insufficiency-identified-Neoplasms', 'Renal Insufficiency-identified-Arthritis, Rheumatoid', 'Parkinson Disease-identified-Dementia', 'Parkinson Disease-identified-Pneumonia', 'Parkinson Disease-identified-Neoplasms', 'Parkinson Disease-identified-Arthritis, Rheumatoid', 'Dementia-identified-Cerebrovascular Disorders', 'Dementia-identified-Pneumonia', 'Dementia-identified-Neoplasms', 'Dementia-identified-Arthritis, Rheumatoid', 'Dementia-identified-Hip Fractures', 'Cerebrovascular Disorders-identified-Pneumonia', 'Cerebrovascular Disorders-identified-Neoplasms', 'Cerebrovascular Disorders-identified-Arthritis, Rheumatoid', 'Pneumonia-identified-Neoplasms', 'Pneumonia-identified-Arthritis, Rheumatoid', 'Pneumonia-identified-Hip Fractures', 'Neoplasms-identified-Arthritis, Rheumatoid', 'Neoplasms-identified-Hip Fractures', 'Arthritis, Rheumatoid-identified-Hip Fractures', 'Osteoarthritis-include-Musculoskeletal Pain', 'Back Pain-include-Musculoskeletal Pain', 'Ventricular Dysfunction, Left-triggered-Inflammation', 'Mastocytosis, Systemic-triggered-Inflammation', 'Idiopathic Pulmonary Fibrosis-lead-Respiratory Insufficiency', 'Fractures, Bone-occur-Sarcopenia', 'Neoplasms-associated-Delayed Emergence from Anesthesia', 'Delayed Emergence from Anesthesia-associated-Neoplasms', 'Sarcopenia-lead-Muscle Weakness', 'Fibrosis-develop-Epilepsy, Absence', 'Aortic Aneurysm-associated-Death', 'Death-associated-Aortic Aneurysm', 'Pancreatic Diseases-investigate-Pancreatitis', 'Death-estimate-Fractures, Bone', 'Cardiac Output, High-increase-Cardiac Output, Low', 'Vasculitis-presented-Brain Neoplasms', 'Death-related-Breast Neoplasms', 'Wounds, Nonpenetrating-include-Wounds and Injuries', 'Brain Diseases, Metabolic-promote-Malnutrition', 'Drug-Related Side Effects and Adverse Reactions-occur-Fibrosis', 'Death-assessed-Sarcopenia', 'Alzheimer Disease-accompanied-Atrophy', 'Alzheimer Disease-describe-Dementia', 'Muscle Weakness-termed-Sarcopenia', 'Cardiovascular Diseases-attributed-Anemia', 'Diabetes Mellitus-associated-Hemolytic-Uremic Syndrome', 'Hemolytic-Uremic Syndrome-associated-Diabetes Mellitus', 'Asthma-lead-Respiratory Distress Syndrome', 'Encephalitis-include-Brain Diseases', 'Heredodegenerative Disorders, Nervous System-include-Brain Diseases', 'Diabetes Mellitus-reveal-Anemia', 'Death-built-Malnutrition', 'Anemia-followed-Death', 'Migraine Disorders-discussed-Dysmenorrhea', 'Osteoarthritis-discussed-Dysmenorrhea', 'Sclerosis-dominated-Aneurysm', 'Sclerosis-dominated-Autoimmune Diseases', 'Sclerosis-dominated-Fibrosis', 'Pain Insensitivity, Congenital-aid-Pain', 'Death-derive-Hypoventilation', 'Death-derive-Respiratory Insufficiency', 'Fractures, Bone-provide-Wounds and Injuries', 'Alcoholism-assess-HIV Infections', 'Xerostomia-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-Xerostomia', 'Alzheimer Disease-performed-Sleep Wake Disorders', 'Sleep Wake Disorders-affect-Alzheimer Disease', 'Heart Diseases-result-Ischemia', 'Liver Failure-result-Ischemia', 'Liver Failure-result-Heart Failure', 'Liver Failure-associated-Heart Failure', 'Heart Failure-associated-Liver Failure', 'Ischemia-associated-Heart Failure', 'Heart Failure-associated-Ischemia', 'Death, Sudden, Cardiac-experience-Hypertension', 'Hypertension-elevated-Heart Failure', 'Epilepsy-generate-Seizures', 'Chronic Disease-generate-Seizures', 'Epilepsy-measure-Seizures', 'Epilepsy-explained-Seizures', 'Epilepsy-explained-Death', 'Epilepsy-identify-Seizures', 'Epilepsy-carry-Death', 'Epilepsy-carry-Seizures', 'Death-carry-Seizures', 'Adenomatous Polyposis Coli-remain-Neoplasms', 'Stomach Neoplasms-represent-Death', 'Death-predict-Colorectal Neoplasms', 'Death-occur-Hemorrhage', 'Myocardial Infarction-occur-Hemorrhage', 'Fractures, Bone-develop-Anemia', 'Fractures, Bone-avoid-Anemia', 'Alzheimer Disease-associated-Heart Failure', 'Heart Failure-associated-Alzheimer Disease', 'Sclerosis-associated-Heart Failure', 'Heart Failure-associated-Sclerosis', 'Arteriolosclerosis-associated-Heart Failure', 'Heart Failure-associated-Arteriolosclerosis', 'Lewy Body Disease-associated-Heart Failure', 'Heart Failure-associated-Lewy Body Disease', 'Infections-lead-Diabetes Mellitus', 'Fractures, Bone-reduced-Acute Kidney Injury', 'Neoplasms-reduced-Acute Kidney Injury', 'Urinary Tract Infections-reduced-Acute Kidney Injury', 'Neoplasms-review-Hernia', 'Stroke-followed-Death', 'Death-followed-Pulmonary Disease, Chronic Obstructive', 'Death-account-Pulmonary Disease, Chronic Obstructive', 'Death-followed-Lung Neoplasms', 'Death-account-Lung Neoplasms', 'Cerebrovascular Disorders-result-Death', 'Pulmonary Disease, Chronic Obstructive-followed-Death', 'Lung Neoplasms-followed-Death', 'Protein-Energy Malnutrition-sustain-Fractures, Bone', 'Stroke-result-Death', 'Respiratory Tract Infections-result-Death', 'Lung Neoplasms-result-Death', 'Alzheimer Disease-investigate-Dementia', 'Death-associated-Wounds, Nonpenetrating', 'Wounds, Nonpenetrating-associated-Death', 'Sarcopenia-caused-Inflammation', 'Inflammation-associated-Malnutrition', 'Malnutrition-associated-Inflammation', 'Lipodystrophy-associated-Infections', 'Infections-associated-Lipodystrophy', 'Lipodystrophy-control-Infections', 'Viremia-associated-Death', 'Death-associated-Viremia', 'Melanoma-eradicate-Neoplasms', 'Neurodegenerative Diseases-involve-Inflammation', 'Osteoarthritis-compare-Cardiac Output, Low', 'Death-increase-Aneurysm', 'Thoracic Injuries-associated-Death', 'Death-associated-Thoracic Injuries', 'Bone Diseases-favor-Vascular Calcification', 'Parkinson Disease-represented-Movement Disorders', 'Movement Disorders-include-Stroke', 'Movement Disorders-seen-Stroke', 'Movement Disorders-predominate-Huntington Disease', 'Neoplasms-purified-Neoplasm Metastasis', 'Neoplasms-affected-Colorectal Neoplasms', 'Neoplasms-purified-Colorectal Neoplasms', 'Neoplasm Metastasis-affected-Colorectal Neoplasms', 'Hypothyroidism-experience-Death', 'Death-experience-Euthyroid Sick Syndromes', 'Infections-observed-Diabetes Mellitus', 'Pneumonia, Aspiration-strengthen-Cough', 'Hypertension-related-Heart Failure', 'Hypertension-related-Stroke', 'Hypertension-related-Myocardial Infarction', 'Neurodegenerative Diseases-act-Chronic Disease', 'Parkinson Disease-concentrate-Inflammation', 'Parkinson Disease-act-Chronic Disease', 'Alzheimer Disease-act-Chronic Disease', 'Chronic Disease-act-Nerve Degeneration', 'Inflammation-form-Neurodegenerative Diseases', 'Melanosis-associated-Polyps', 'Polyps-associated-Melanosis', 'Melanosis-associated-Adenoma', 'Adenoma-associated-Melanosis', 'Melanosis-associate-Polyps', 'Polyps-associate-Melanosis', 'Melanosis-associate-Adenoma', 'Adenoma-associate-Melanosis', 'Melanosis-remain-Adenoma', 'Melanosis-associate-Adenocarcinoma', 'Adenocarcinoma-associate-Melanosis', 'Dementia-progress-Alzheimer Disease', 'Hypotension, Orthostatic-associated-Wounds and Injuries', 'Wounds and Injuries-associated-Hypotension, Orthostatic', 'Osteoarthritis-associated-Dementia', 'Dementia-associated-Osteoarthritis', 'Osteoarthritis-associated-Arthritis', 'Arthritis-associated-Osteoarthritis', 'Osteoarthritis-demonstrate-Dementia', 'Osteoarthritis-demonstrate-Death', 'Osteoarthritis-reduced-Death', 'Cerebral Palsy-reduce-Muscle Spasticity', 'Cardiovascular Diseases-admitted-Delirium', 'Blindness-followed-Corneal Opacity', 'Acquired Immunodeficiency Syndrome-followed-Cardiovascular Diseases', 'Stroke-include-Brain Diseases', 'Obesity-result-Cardiovascular Diseases', 'Obesity-result-Neurodegenerative Diseases', 'Hyperglycemia-associated-Atrophy', 'Atrophy-associated-Hyperglycemia', 'Heart Failure-associated-Malnutrition', 'Malnutrition-associated-Heart Failure', 'Euthyroid Sick Syndromes-associated-Malnutrition', 'Malnutrition-associated-Euthyroid Sick Syndromes', 'Deglutition Disorders-named-Sarcopenia', 'Deglutition Disorders-caused-Sarcopenia', 'Sarcopenia-named-Deglutition Disorders', 'Sarcopenia-caused-Deglutition Disorders', 'Sarcopenia-become-Pneumonia', 'Sarcopenia-prevent-Pneumonia', 'Cough-prevent-Pneumonia, Aspiration', 'Pneumonia, Aspiration-induce-Muscular Atrophy', 'Pneumonia-show-Death', 'Pneumonia, Aspiration-show-Death', 'Cerebrovascular Disorders-tend-Cerebral Infarction', 'Cerebrovascular Disorders-focus-Cerebral Infarction', 'Spinal Cord Injuries-develop-Ulcer', 'Vision Disorders-result-Glycogen Storage Disease Type II', 'Tauopathies-initiate-Alzheimer Disease', 'Atrophy-occur-Alzheimer Disease', 'Tauopathies-played-Alzheimer Disease', 'Peripheral Nervous System Diseases-managed-Hypertension', 'Peripheral Nervous System Diseases-managed-Obesity', 'Diabetes Mellitus-managed-Hypertension', 'Diabetes Mellitus-managed-Obesity', 'Peripheral Nervous System Diseases-ameliorate-Diabetes Mellitus', 'Myotonic Dystrophy-suffer-Glucose Metabolism Disorders', 'Hearing Loss-define-Hearing Loss, Noise-Induced', 'Tinnitus-define-Hearing Loss, Noise-Induced', 'Mycoses-develop-Drug-Related Side Effects and Adverse Reactions', 'Poliomyelitis-involve-Sleep Wake Disorders', 'Heart Failure-seen-Heart Diseases', 'Heat Stress Disorders-associated-Fever', 'Fever-associated-Heat Stress Disorders', 'Visceral Pain-sense-Appendicitis', 'Atrophy-observed-Parkinson Disease', 'Parkinson Disease-presented-Atrophy', 'Parkinson Disease-convert-Camurati-Engelmann Syndrome', 'Respiratory Tract Diseases-exclude-Lung Neoplasms', 'Parkinson Disease-increasing-Death', 'Heredodegenerative Disorders, Nervous System-increasing-Death', 'Hypercholesterolemia-include-Cardiovascular Diseases', 'Ischemia-include-Cardiovascular Diseases', 'Status Epilepticus-covered-Seizures', 'Heart Diseases-assessed-Syncope', 'Heart Diseases-missed-Cardiac Conduction System Disease', 'Heart Diseases-missed-Syncope, Vasovagal', 'Fatigue-use-Chronic Disease', 'Seizures-entrenched-Epilepsy', 'Diabetes Mellitus-predict-Thrombosis', 'Osteoporosis-share-Calcinosis', 'Drug-Related Side Effects and Adverse Reactions-include-Mitochondrial Diseases', 'HIV Infections-induce-Inflammation', 'HIV Infections-lead-Viremia', 'Inflammation-induce-Viremia', 'Sjogren-Larsson Syndrome-increase-Neoplasms', 'Necrosis-exhibit-Pancreatitis, Acute Necrotizing', 'Wounds and Injuries-show-Death', 'Drug-Related Side Effects and Adverse Reactions-define-Neoplasms', 'Diabetes Mellitus-lead-Cardiovascular Diseases', 'Diabetes Mellitus-lead-Stroke', 'Diabetes Mellitus-lead-Peripheral Arterial Disease', 'Diabetes Mellitus-lead-Kidney Diseases', 'Diabetes Mellitus-lead-Nervous System Diseases', 'Diabetes Mellitus-lead-Retinal Diseases', 'Diabetes Mellitus-lead-Musculoskeletal Diseases', 'Pain-evaluated-Postpartum Hemorrhage', 'Vision Disorders-experience-Ischemia', 'HIV Infections-considered-Chronic Disease', 'Hypothyroidism-develop-Myxedema', 'Lung Diseases, Interstitial-worsen-Death', 'Lung Diseases, Interstitial-occur-Arthritis, Rheumatoid', 'Lung Diseases, Interstitial-related-Arthritis, Rheumatoid', 'Malnutrition-prevent-Nervous System Diseases', 'Atrial Fibrillation-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-Atrial Fibrillation', 'Cerebrovascular Disorders-include-Pneumonia', 'Cerebrovascular Disorders-include-Infarction', 'Cerebrovascular Disorders-include-Stroke, Lacunar', 'Sclerosis-observed-Craniocerebral Trauma', 'Diabetes Mellitus-associated-Hypotension, Orthostatic', 'Hypotension, Orthostatic-associated-Diabetes Mellitus', 'Diabetes Mellitus-represent-Hypotension, Orthostatic', 'Lung Diseases-decrease-Respiratory Tract Diseases', 'Growth Disorders-employed-Hirsutism', 'Coronary Artery Disease-provide-Inflammation', 'Atrophy-observed-Neoplasms', 'Kidney Diseases-stimulated-Immunologic Deficiency Syndromes', 'Kidney Diseases-stimulated-Hypocalcemia', 'Coronary Artery Disease-stratified-Heart Diseases', 'Heart Diseases-increase-Coronary Artery Disease', 'Sleep Initiation and Maintenance Disorders-associated-Cardiac Output, Low', 'Cardiac Output, Low-associated-Sleep Initiation and Maintenance Disorders', 'Postoperative Cognitive Complications-related-Dementia', 'Leptospirosis-considered-Communicable Diseases', 'Neurodegenerative Diseases-related-Alzheimer Disease', 'Atrial Fibrillation-related-Cerebral Infarction', 'Atrial Fibrillation-related-Stroke', 'Atrial Fibrillation-search-Stroke', 'Cerebral Infarction-proposed-Stroke', 'Thromboembolism-attributed-Atrial Fibrillation', 'Atrial Fibrillation-detected-Cerebral Infarction', 'Thromboembolism-attributed-Cerebral Infarction', 'Cerebral Infarction-detect-Atrial Fibrillation', 'Atrial Fibrillation-monitor-Stroke', 'Muscular Diseases-increase-Atrial Fibrillation', 'Stroke-fulfil-Atrial Fibrillation', 'Ischemia-associated-Stroke', 'Stroke-associated-Ischemia', 'Stroke-associated-Embolism', 'Embolism-associated-Stroke', 'Ischemia-associated-Embolism', 'Embolism-associated-Ischemia', 'Atrial Fibrillation-required-Ischemia', 'Hepatitis B-tolerate-Arthritis, Rheumatoid', 'Fractures, Bone-live-HIV Infections', 'Dementia-challenge-Delirium', 'Chest Pain-caused-Klebsiella Infections', 'Chest Pain-differentiate-Klebsiella Infections', 'Pneumococcal Infections-differentiate-Klebsiella Infections', 'Alzheimer Disease-implicated-Memory Disorders', 'Osteoarthritis-associated-Ovarian Neoplasms', 'Ovarian Neoplasms-associated-Osteoarthritis', 'Bone Neoplasms-associated-Alzheimer Disease', 'Alzheimer Disease-associated-Bone Neoplasms', 'Bone Diseases, Metabolic-contribute-Neurodegenerative Diseases', 'Bone Diseases, Metabolic-associated-Alzheimer Disease', 'Alzheimer Disease-associated-Bone Diseases, Metabolic', 'Pelvic Neoplasms-tend-Multiple Trauma', 'Pelvic Neoplasms-associated-Multiple Trauma', 'Multiple Trauma-associated-Pelvic Neoplasms', 'Dementia-process-Pain', 'Dementia-assess-Pain', 'Dementia-decrease-Headache Disorders, Secondary', 'Pain-associated-Psychomotor Agitation', 'Psychomotor Agitation-associated-Pain', 'Pain-decrease-Headache Disorders, Secondary', 'Psychomotor Agitation-decrease-Headache Disorders, Secondary', 'Hypesthesia-include-Nervous System Diseases', 'Heart Diseases-confirm-Amyloidosis', 'Pain-include-Nervous System Diseases', 'Muscle Weakness-include-Nervous System Diseases', 'Mandibular Nerve Injuries-include-Nervous System Diseases', 'Headache-comprise-Headache Disorders, Primary', 'Headache Disorders, Primary-include-Migraine Disorders', 'Headache Disorders, Primary-include-Headache', 'Urinary Incontinence-enhance-Dementia', 'Stroke-remain-Death', 'Nervous System Diseases-interfere-Death', 'Dementia-present-Gingival Hemorrhage', 'Dementia-present-Inflammation', 'Gingival Hemorrhage-suffer-Periodontal Diseases', 'Inflammation-suffer-Periodontal Diseases', 'Periodontal Diseases-contribute-Dementia', 'Cerebrovascular Disorders-compare-Parkinson Disease', 'Parkinson Disease-play-Cerebrovascular Disorders', 'Sarcopenia-associated-Dysbiosis', 'Dysbiosis-associated-Sarcopenia', 'Fractures, Bone-demonstrate-Hip Fractures', 'Fractures, Bone-demonstrate-Obesity', 'Diabetes Mellitus, Type 2-decrease-Diabetes Mellitus', 'Gangrene-support-Diabetes Mellitus', 'Aneuploidy-cause-Abnormalities, Drug-Induced', 'Aneuploidy-associated-Neoplasms', 'Neoplasms-associated-Aneuploidy', 'Abnormalities, Drug-Induced-associated-Neoplasms', 'Neoplasms-associated-Abnormalities, Drug-Induced', 'Motor Neuron Disease-boost-Death', 'Cerebral Infarction-emphasize-Ischemia', 'Immunologic Deficiency Syndromes-follow-Skin Diseases', 'Immunologic Deficiency Syndromes-result-Skin Diseases', 'Pain-identify-Musculoskeletal Diseases', 'Hereditary Breast and Ovarian Cancer Syndrome-identify-Musculoskeletal Diseases', 'Gait Disorders, Neurologic-identify-Musculoskeletal Diseases', 'Sarcopenia-identify-Musculoskeletal Diseases', 'Carcinoma, Non-Small-Cell Lung-perform-Neoplasms', 'Atrial Fibrillation-included-Death', 'Atrial Fibrillation-included-Cerebral Infarction', 'Sarcopenia-remain-Death', 'Gait Disorders, Neurologic-underpin-Dementia', 'Cataract-associated-Rupture', 'Rupture-associated-Cataract', 'Cataract-associated-Vitreous Hemorrhage', 'Vitreous Hemorrhage-associated-Cataract', 'Cataract-associated-Iris Diseases', 'Iris Diseases-associated-Cataract', 'Cataract-associated-Inflammation', 'Inflammation-associated-Cataract', 'Cushing Syndrome-present-Hypertension', 'Atrial Fibrillation-present-Hypertension', 'Hypertension-exert-Cardiovascular Diseases', 'Dyslipidemias-exert-Cardiovascular Diseases', 'Postoperative Complications-include-Death', 'Renal Insufficiency, Chronic-followed-Kidney Failure, Chronic', 'Renal Insufficiency, Chronic-followed-Death', 'Kidney Failure, Chronic-occur-Cardiovascular Diseases', 'Kidney Failure, Chronic-followed-Death', 'Kidney Failure, Chronic-followed-Cardiovascular Diseases', 'Macular Degeneration-participate-Vision Disorders', 'Granuloma-identified-Gout', 'Stroke-require-Death', 'Stroke-require-Cardiovascular Diseases', 'Embolism-require-Death', 'Embolism-require-Cardiovascular Diseases', 'Hemorrhage-require-Death', 'Hemorrhage-require-Cardiovascular Diseases', 'Sarcopenia-associated-Bone Neoplasms', 'Bone Neoplasms-associated-Sarcopenia', 'Cardiomyopathy, Hypertrophic-associated-Death', 'Death-associated-Cardiomyopathy, Hypertrophic', 'Aneurysm-approach-Mastocytosis, Systemic', 'Cerebral Small Vessel Diseases-include-Microvascular Angina', 'Albuminuria-include-Microvascular Angina', 'Retinal Arterial Macroaneurysm-include-Microvascular Angina', 'Hyperemia-include-Microvascular Angina', 'Osteoarthritis-improve-Pain', 'Tremor-begin-Parkinson Disease', 'Tremor-accompanied-Hypokinesia', 'Tremor-accompanied-Muscle Rigidity', 'Parkinson Disease-accompanied-Hypokinesia', 'Parkinson Disease-accompanied-Muscle Rigidity', 'Cardiovascular Diseases-indicate-Obesity', 'Metabolic Diseases-indicate-Obesity', 'Malaria-cause-Parasitemia', 'Heart Arrest-caused-Neoplasms', 'Diabetes Mellitus-estimate-Death', 'Sarcopenia-defined-Stomach Neoplasms', 'Fatigue-incorporated-Diabetes Mellitus', 'Amyloidosis-lead-Heart Failure', 'Amyloidosis-lead-Arrhythmias, Cardiac', 'Heart Failure-confirmed-Death', 'Death-include-Hypothermia', 'Death-identified-Hypothermia', 'Mitochondrial Diseases-associated-Metabolism, Inborn Errors', 'Metabolism, Inborn Errors-associated-Mitochondrial Diseases', 'Mitochondrial Diseases-range-Metabolism, Inborn Errors', 'Denys-Drash Syndrome-result-Hypertension', 'Inflammation-induce-Osteoporosis', 'Cancer Pain-differ-Pain', 'Bone Neoplasms-reduce-Fractures, Bone', 'Sarcopenia-compare-Cardiovascular Diseases', 'Sarcopenia-compare-Respiratory Tract Diseases', 'Sarcopenia-compare-Pulmonary Disease, Chronic Obstructive', 'Death-experience-Sarcopenia', 'Respiratory Tract Diseases-experience-Sarcopenia', 'Sarcopenia-associated-Respiratory Tract Diseases', 'Respiratory Tract Diseases-associated-Sarcopenia', 'Sarcopenia-associated-Pulmonary Disease, Chronic Obstructive', 'Pulmonary Disease, Chronic Obstructive-associated-Sarcopenia', 'Progeria-exhibit-Pigmentation Disorders', 'Hypertension-explain-Heart Failure', 'Neuralgia-considered-Neoplasms', 'Neoplasms-rule-Neuralgia', 'Dysbiosis-involved-Sarcopenia', 'Neurologic Manifestations-induce-Dysbiosis', 'Neurologic Manifestations-exacerbate-Sarcopenia', 'Dysbiosis-exacerbate-Sarcopenia', 'Dysbiosis-induce-Atherosclerosis', 'Dysbiosis-induce-Thrombosis', 'Dysbiosis-induce-Metabolic Syndrome', 'Dysbiosis-induce-Hypertension', 'Hypertension-affect-Dementia', 'Cerebrovascular Disorders-trigger-Dementia, Vascular', 'Dementia-focus-Alzheimer Disease', 'Cerebrovascular Disorders-trigger-Alzheimer Disease', 'Dementia, Vascular-trigger-Alzheimer Disease', 'Dementia, Vascular-trigger-Neurotoxicity Syndromes', 'Infections-regulate-Inflammation', 'Sotos Syndrome-delay-Carcinoma, Hepatocellular', 'Fibrosis-induce-Stroke', 'Heredodegenerative Disorders, Nervous System-caused-Death', 'Hyperuricemia-mediate-Heart Failure', 'Hyperuricemia-correlate-Heart Failure', 'Hyperuricemia-improve-Heart Failure', 'Hyperhomocysteinemia-associated-Renal Insufficiency, Chronic', 'Renal Insufficiency, Chronic-associated-Hyperhomocysteinemia', 'Hypertriglyceridemia-associated-Renal Insufficiency, Chronic', 'Renal Insufficiency, Chronic-associated-Hypertriglyceridemia', 'Atherosclerosis-cause-Death', 'Huntington Disease-lead-Movement Disorders', 'Neurodegenerative Diseases-lead-Movement Disorders', 'Ocular Hypertension-include-Glaucoma', 'Cardiac Output, Low-associated-Lung Diseases', 'Lung Diseases-associated-Cardiac Output, Low', 'Cardiac Output, Low-associated-Stroke', 'Stroke-associated-Cardiac Output, Low', 'Dementia-suffer-Fractures, Bone', 'Cardiac Output, Low-associated-Seizures', 'Seizures-associated-Cardiac Output, Low', 'Gingival Overgrowth-exhibit-Scoliosis', 'Gingival Overgrowth-exhibit-Musculoskeletal Diseases', 'Gingival Overgrowth-exhibit-Myofibroma', 'Gingival Overgrowth-exhibit-Arachnoid Cysts', 'Gingival Overgrowth-exhibit-Leukoencephalopathies', 'Pain-focus-Death', 'Dementia-exist-Neurodegenerative Diseases', 'Dementia-confound-Alzheimer Disease', 'Neurodegenerative Diseases-confound-Alzheimer Disease', 'Brain Injuries, Traumatic-evaluate-Alzheimer Disease', 'Brain Injuries, Traumatic-moderate-Alzheimer Disease', 'Death-recommend-Atrial Fibrillation', 'Death-diminish-Atrial Fibrillation', 'Hypogonadism-report-Fatigue', 'Spinal Cord Diseases-predispose-Spinal Cord Injuries', 'Hypertension-reduce-Dementia', 'Carcinoma, Hepatocellular-show-Neoplasms', 'Diabetes Mellitus-promote-Rupture', 'Mitochondrial Diseases-develop-Alzheimer Disease', 'Lysosomal Storage Diseases-identified-Parkinson Disease', 'Parkinson Disease-implicate-Lysosomal Storage Diseases', 'Tuberculosis-include-Tuberculosis, Pulmonary', 'Voice Disorders-coexist-Respiratory Tract Infections', 'Dysphonia-cause-Voice Disorders', 'Atrophy-cause-Voice Disorders', 'Ependymoma-lead-Heart Failure', 'Death-lead-Heart Failure', 'Cerebral Amyloid Angiopathy-found-Alzheimer Disease', 'Cerebral Amyloid Angiopathy-accompany-Cerebrovascular Disorders', 'Cerebral Amyloid Angiopathy-found-Dementia', 'Cerebral Amyloid Angiopathy-accompany-Dementia', 'Alzheimer Disease-accompany-Cerebrovascular Disorders', 'Sleep Initiation and Maintenance Disorders-associated-Cerebral Infarction', 'Cerebral Infarction-associated-Sleep Initiation and Maintenance Disorders', 'Sleep Wake Disorders-associated-Cerebral Infarction', 'Cerebral Infarction-associated-Sleep Wake Disorders', 'Granulomatosis with Polyangiitis-diagnosed-Arthritis, Rheumatoid', 'Granulomatosis with Polyangiitis-present-Multiple Pulmonary Nodules', 'Fibromyalgia-base-Pain', 'Pain-accelerate-Alzheimer Disease', 'Chronic Pain-occur-Neurodegenerative Diseases', 'Chronic Pain-occur-Alzheimer Disease', 'Mastocytosis, Systemic-influence-Pain', 'Leukoencephalopathies-derived-Leukoaraiosis', 'Leukoencephalopathies-evaluate-Leukoaraiosis', 'Dermatitis, Contact-evaluate-Dermatitis, Atopic', 'Eczema-evaluate-Dermatitis, Atopic', 'Urticaria-evaluate-Dermatitis, Atopic', 'Dermatitis, Atopic-evaluate-Pruritus', 'Dermatitis, Atopic-evaluate-Skin Diseases, Eczematous', 'Vascular Calcification-found-Progeria', 'Vascular Calcification-extend-Progeria', 'Vascular Calcification-prevent-Progeria', 'Diabetes Mellitus-drive-Hypoglycemia', 'Diabetes Mellitus-recruit-Hypoglycemia', 'Carcinoma, Hepatocellular-use-Neoplasms', 'Viremia-contribute-Carcinoma, Hepatocellular', 'Parkinson Disease-caused-Necrosis', 'Neoplasms-compared-Pain', 'Abnormalities, Drug-Induced-lead-Neoplasms', 'Critical Illness-involved-Pain', 'Constipation-cause-Myocardial Infarction', 'Kidney Calculi-cause-Myocardial Infarction', 'Sarcopenia-manage-Osteoporotic Fractures', 'Obesity-diagnosed-Coronary Artery Disease', 'Dementia-related-Seizures', 'Dementia-estimate-Seizures', 'Death-related-Seizures', 'Seizures-reduce-Dementia', 'Seizures-assess-Dementia', 'Pain-present-Spondylitis, Ankylosing', 'Syncope-suggest-Spondylitis, Ankylosing', 'Ocular Hypertension-treated-Glaucoma', 'Hematoma, Subdural-associated-Postoperative Hemorrhage', 'Postoperative Hemorrhage-associated-Hematoma, Subdural', 'Postoperative Hemorrhage-show-Death', 'Hematologic Diseases-associated-Postoperative Hemorrhage', 'Postoperative Hemorrhage-associated-Hematologic Diseases', 'Postoperative Hemorrhage-rise-Death', 'Aneurysm-related-Psychomotor Disorders', 'Bone Diseases-associated-Death', 'Death-associated-Bone Diseases', 'Sarcopenia-defined-Muscular Dystrophy, Duchenne', 'Sarcopenia-combined-Muscular Dystrophy, Duchenne', 'Sarcopenia-combined-Osteoporosis', 'Osteosarcoma-prevent-Bone Neoplasms', 'Epilepsy-cause-Death', 'Diabetes Insipidus-diagnosed-Polyuria', 'Diabetes Insipidus-diagnosed-Hypernatremia', 'Adenocarcinoma-manifest-Diabetes Insipidus', 'Drug-Related Side Effects and Adverse Reactions-consist-Fibrosis', 'Death-decrease-Coronary Artery Disease', 'Death-decrease-Heart Failure', 'Osteoarthritis-dwindle-Vision, Low', 'Xeroderma Pigmentosum-caused-Genetic Diseases, Inborn', 'Cockayne Syndrome-caused-Genetic Diseases, Inborn', 'Trichothiodystrophy Syndromes-caused-Genetic Diseases, Inborn', 'Cardiovascular Diseases-exhibit-Hypertension, Pulmonary', 'Cardiovascular Diseases-exhibit-Arrhythmias, Cardiac', 'Cystic Fibrosis-contribute-Death', 'Infections-increasing-Cystic Fibrosis', 'Death-quantify-Fractures, Bone', 'Genetic Diseases, Inborn-associated-Intervertebral Disc Degeneration', 'Intervertebral Disc Degeneration-associated-Genetic Diseases, Inborn', 'Obesity, Abdominal-associated-Colorectal Neoplasms', 'Colorectal Neoplasms-associated-Obesity, Abdominal', 'Chronic Pain-defined-Pain', 'Gallbladder Diseases-discovered-Cholecystitis', 'Neoplasms-kill-Infections', 'Lymphoma-accelerate-Burkitt Lymphoma', 'Asthma-decline-Death', 'Pneumococcal Infections-affect-Respiratory Tract Diseases', 'Neurodegenerative Diseases-share-Alzheimer Disease', 'Neurodegenerative Diseases-shared-Alzheimer Disease', 'Hypoglycemia-affect-Diabetes Mellitus, Type 2', 'Sarcopenia-associated-Infections', 'Infections-associated-Sarcopenia', 'Sarcopenia-associated-Hernia', 'Hernia-associated-Sarcopenia', 'Metabolic Syndrome-defined-Atherosclerosis', 'Diabetes Mellitus-defined-Atherosclerosis', 'Progeria-overlap-Atherosclerosis', 'Progeria-overlap-Arthritis', 'Progeria-overlap-Lipodystrophy', 'Psychomotor Agitation-associated-Sleep Wake Disorders', 'Sleep Wake Disorders-associated-Psychomotor Agitation', 'Pain-defined-Low Back Pain', 'Status Epilepticus-include-Renal Tubular Transport, Inborn Errors', 'Sensation Disorders-include-Renal Tubular Transport, Inborn Errors', 'Skin Neoplasms-identified-Neoplasms', 'Neoplasms-identified-Renal Insufficiency, Chronic', 'Carcinoma, Squamous Cell-compare-Skin Neoplasms', 'Carcinoma, Squamous Cell-compare-Renal Insufficiency, Chronic', 'Carcinoma, Squamous Cell-include-Renal Insufficiency, Chronic', 'Renal Insufficiency, Chronic-include-Skin Neoplasms', 'Muscular Diseases-followed-Arthritis, Juvenile', 'Cardiovascular Abnormalities-associated-Slipped Capital Femoral Epiphyses', 'Slipped Capital Femoral Epiphyses-associated-Cardiovascular Abnormalities', 'Hyperostosis-associated-Slipped Capital Femoral Epiphyses', 'Slipped Capital Femoral Epiphyses-associated-Hyperostosis', 'Osteoarthritis-associated-Slipped Capital Femoral Epiphyses', 'Slipped Capital Femoral Epiphyses-associated-Osteoarthritis', 'Fractures, Bone-show-Oculocerebrorenal Syndrome', 'Acute Kidney Injury-diminish-Critical Illness', 'Acute Kidney Injury-diminish-Wounds and Injuries', 'Peripheral Arterial Disease-share-Cardiovascular Diseases', 'Sleep Initiation and Maintenance Disorders-justify-Dementia', 'Aneurysm-known-Peripheral Arterial Disease', 'Pain-associated-Alcoholism', 'Alcoholism-associated-Pain', 'Osteoarthritis-seen-Inflammation', 'Osteoarthritis-seen-Bone Diseases', 'Osteoarthritis-seen-Synovitis', 'Inflammation-involve-Bone Diseases', 'Cerebellar Ataxia-characterized-Atrophy', 'Death-associated-Pulmonary Aspergillosis', 'Pulmonary Aspergillosis-associated-Death', 'Stroke-droppe-Death', 'Cerebral Infarction-driven-Stroke', 'Metabolic Diseases-affect-Alzheimer Disease', 'Endometrial Neoplasms-defined-Neoplasms', 'Thyroid Diseases-include-Chronic Disease', 'Obesity-occur-Sarcopenia', 'Muscular Diseases-improve-Epilepsy', 'Cachexia-become-Neoplasms', 'Muscular Atrophy-induced-Neoplasms', 'Neoplasms-known-Cachexia', 'Muscular Atrophy-induced-Metabolic Diseases', 'Neoplasms-wasting-Metabolic Diseases', 'Neoplasms-induced-Metabolic Diseases', 'Sleep Initiation and Maintenance Disorders-hear-Hearing Loss', 'Urinary Incontinence-hear-Hearing Loss', 'Sleep Wake Disorders-assessed-Death', 'Hyponatremia-predispose-Cardiac Output, Low', 'Hyponatremia-predispose-Fractures, Bone', 'Nervous System Diseases-lead-Parkinson Disease', 'Nervous System Diseases-lead-Huntington Disease', 'Nervous System Diseases-threaten-Lewy Body Disease', 'Nervous System Diseases-lead-Lewy Body Disease', 'Diabetes Mellitus-lead-Muscle Rigidity', 'Candidiasis, Oral-increase-Chronic Disease', 'Lewy Body Disease-encompass-Dementia', 'Lewy Body Disease-encompass-Parkinson Disease', 'Hernia-schedule-Memory Disorders', 'Ataxia Telangiectasia-characterized-Retinal Degeneration', 'Ataxia Telangiectasia-characterized-Dysgammaglobulinemia', 'Nijmegen Breakage Syndrome-belong-Primary Immunodeficiency Diseases', 'Primary Immunodeficiency Diseases-characterized-Retinal Degeneration', 'Primary Immunodeficiency Diseases-characterized-Dysgammaglobulinemia', 'Primary Immunodeficiency Diseases-characterized-Neoplasms', 'Myocardial Infarction-compare-Cerebral Infarction', 'Mitochondrial Diseases-proposed-Alzheimer Disease', 'Metabolic Diseases-reduce-Blood Protein Disorders', 'Sleep Wake Disorders-associate-Carotid Artery Diseases', 'Carotid Artery Diseases-associate-Sleep Wake Disorders', 'Inflammatory Bowel Diseases-find-Inflammation', 'Parkinson Disease-induce-Inflammation', 'Inflammatory Bowel Diseases-compare-Parkinson Disease', 'Inflammation-contribute-Parkinson Disease', 'Parkinson Disease-impact-Inflammatory Bowel Diseases', 'HIV Infections-known-Arteriosclerosis', 'Periodontitis-characterized-Dysbiosis', 'Chronic Disease-characterized-Dysbiosis', 'Chronic Disease-suffer-Neurodegenerative Diseases', 'Hypoxia-resist-Neoplasms', 'Dementia-include-Death', 'Obesity-affect-Erectile Dysfunction', 'Infarction-demonstrate-Sinusitis', 'Chronic Disease-control-Dementia', 'Hypertension-do-Diabetes Mellitus', 'Hypertension-increase-Neoplasms', 'Stroke-do-Peripheral Vascular Diseases', 'Hypertrophy-increase-Nephrosclerosis', 'Hypertension-related-Immunologic Deficiency Syndromes', 'Hypertension-lost-Hypertrophy', 'Immunologic Deficiency Syndromes-lost-Hypertrophy', 'Kidney Diseases-overlap-Hypertension', 'Kidney Diseases-overlap-Kidney Failure, Chronic', 'Kidney Diseases-overlap-Glomerulonephritis', 'Hypertension-overlap-Kidney Failure, Chronic', 'Hypertension-overlap-Glomerulonephritis', 'Kidney Failure, Chronic-overlap-Glomerulonephritis', 'Drug-Related Side Effects and Adverse Reactions-occur-Cardiotoxicity', 'Fibrosis-develop-Ovarian Neoplasms', 'Metabolic Syndrome-associated-Osteoporosis', 'Osteoporosis-associated-Metabolic Syndrome', 'Neurodegenerative Diseases-used-Alzheimer Disease', 'Neurodegenerative Diseases-distinguish-Alzheimer Disease', 'Aniseikonia-occur-Epiretinal Membrane', 'Necrosis-cause-Gastrointestinal Hemorrhage', 'Epilepsy-incurred-Parkinson Disease', 'Epilepsy-incurred-Arteriovenous Malformations', 'Epilepsy-incurred-Wounds and Injuries', 'Neurodegenerative Diseases-leave-Retinal Diseases', 'Retinal Diseases-treat-Diabetes Mellitus', 'Brain Ischemia-elicit-Alzheimer Disease', 'Brain Ischemia-facilitate-Dementia', 'Infections-cause-Infertility, Female', 'Infections-cause-Genetic Diseases, Inborn', 'Erectile Dysfunction-caused-Mandibular Nerve Injuries', 'Infertility, Female-cause-Genetic Diseases, Inborn', 'Atrial Fibrillation-demonstrate-Mitral Valve Insufficiency', 'Carcinoma, Squamous Cell-result-Death', 'Hypesthesia-occur-Muscular Atrophy', 'Pain-occur-Muscular Atrophy', 'Carpal Tunnel Syndrome-diagnose-Hypesthesia', 'Atrophy-result-Ataxia', 'Atrophy-avoid-Carpal Tunnel Syndrome', 'Osteoporosis-focused-Hyperparathyroidism, Secondary', 'Coinfection-provide-Neurodegenerative Diseases', 'Brain Injuries, Traumatic-cause-Death', 'Coinfection-share-Neurodegenerative Diseases', 'Coinfection-followed-Cardiomyopathies', 'Cardiomyopathies-followed-Neurodegenerative Diseases', 'Cardiomyopathies-trigger-Neurodegenerative Diseases', 'Coinfection-trigger-Neurodegenerative Diseases', 'Urinary Tract Infections-associated-Death', 'Death-associated-Urinary Tract Infections', 'Prostatic Hyperplasia-minimise-Sexual Dysfunction, Physiological', 'Thrombophilia-evaluate-Inflammation', 'Death-related-Obesity', 'Osteoporosis-culminate-Fractures, Bone', 'Inflammation-explore-Communicable Diseases', 'Fibrosis-explore-Communicable Diseases', 'Fibrosis-cause-Renal Insufficiency', 'Breast Neoplasms-extracted-Neoplasms', 'Neoplasm Invasiveness-include-Neoplasms', 'Liver Cirrhosis-include-Neoplasms', 'Papilloma-present-Polyps', 'Neoplasms-present-Polyps', 'Atrial Fibrillation-coincide-Heart Failure', 'Delirium-identified-Dementia', 'Heredodegenerative Disorders, Nervous System-lead-Sexual Dysfunction, Physiological', 'Delirium-progress-Dementia', 'Inflammation-preserve-Polymyalgia Rheumatica', 'Polycythemia Vera-predicted-Essential Tremor', 'Inflammation-implicated-Cardiovascular Diseases', 'Neurodegenerative Diseases-present-Memory Disorders', 'Hearing Loss-include-Dementia', 'Obesity-associated-Hearing Loss', 'Hearing Loss-associated-Obesity', 'Neoplasms-influenced-Dehydration', 'Arbovirus Infections-include-Cough', 'Arbovirus Infections-include-Chest Pain', 'Arbovirus Infections-include-Headache', 'Arbovirus Infections-include-Myalgia', 'Fractures, Bone-tend-Contracture', 'Hyperglycemia-characterized-Ischemia', 'Hyperglycemia-characterized-Inflammation', 'Inflammation-contribute-Vision Disorders', 'Sarcopenia-cause-Renal Insufficiency, Chronic', 'Sarcopenia-include-Chronic Kidney Disease-Mineral and Bone Disorder', 'Fractures, Bone-befal-Osteoporotic Fractures', 'Fractures, Bone-prevent-Pneumonia', 'Cardiovascular Diseases-compare-Respiratory Tract Diseases', 'Cold Injury-increase-Respiratory Tract Diseases', 'Erectile Dysfunction-live-HIV Infections', 'Xerostomia-rate-Headache Disorders, Secondary', 'Dry Eye Syndromes-report-Xerostomia', 'Cardiovascular Diseases-remain-Heart Failure', 'Atrial Fibrillation-range-Dementia', 'Cerebral Infarction-linked-Atrial Fibrillation', 'Cerebral Infarction-considered-Atrial Fibrillation', 'Atherosclerosis-associated-Ischemia', 'Ischemia-associated-Atherosclerosis', 'Atherosclerosis-associated-Abdominal Pain', 'Abdominal Pain-associated-Atherosclerosis', 'Atherosclerosis-occur-Cardiovascular Diseases', 'Ischemia-occur-Cardiovascular Diseases', 'Abdominal Pain-occur-Cardiovascular Diseases', 'Osteoporosis-warranted-Hyperparathyroidism', 'Osteoporosis-warranted-Renal Insufficiency, Chronic', 'Fractures, Bone-reevaluated-Osteoporosis', 'Skin Diseases-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-Skin Diseases', 'Skin Diseases-associated-Neoplasms', 'Neoplasms-associated-Skin Diseases', 'Skin Diseases-associated-Psoriasis', 'Psoriasis-associated-Skin Diseases', 'Idiopathic Pulmonary Fibrosis-include-Death', 'Breast Neoplasms-include-Diabetes Mellitus', 'Neoplasms-estimate-Breast Neoplasms', 'Obesity-associated-Hypothalamic Neoplasms', 'Hypothalamic Neoplasms-associated-Obesity', 'Obesity-compromise-Virilism', 'Neoplasms-minimize-Cardiotoxicity', 'Parkinson Disease-followed-Dementia', 'Death-caused-Wounds and Injuries', 'Parkinson Disease-show-Death', 'Fatigue-increase-Sleep Wake Disorders', 'Tuberculosis-reported-Carcinoma, Hepatocellular', 'Death-cause-Parkinson Disease', 'Liver Diseases-confirmed-Carcinoma, Hepatocellular', 'Liver Diseases-confirmed-Tuberculosis', 'Pain-related-Chronic Disease', 'Malocclusion-identify-Spinal Cord Injuries', 'Respiratory Tract Diseases-result-Death', 'Brachial Plexus Neuropathies-associated-Aneurysm', 'Aneurysm-associated-Brachial Plexus Neuropathies', 'Disorders of Excessive Somnolence-present-Pain', 'Disorders of Excessive Somnolence-present-Paralysis', 'Cerebrovascular Disorders-associated-Dementia, Vascular', 'Dementia, Vascular-associated-Cerebrovascular Disorders', 'Weight Loss-find-Osteoarthritis', 'Weight Loss-begin-Pain', 'Sarcopenia-include-Neoplasms', 'Sarcopenia-include-Pulmonary Disease, Chronic Obstructive', 'Sarcopenia-include-Heart Failure', 'Sarcopenia-include-Renal Insufficiency', 'Wounds and Injuries-receive-Brain Injuries', 'Wounds and Injuries-receive-Pelvic Neoplasms', 'Wounds and Injuries-receive-Fractures, Bone', 'Brain Neoplasms-discovered-Carcinoma, Squamous Cell', 'Hypoalphalipoproteinemias-undergo-Hypertrophy', 'Pneumonia, Aspiration-evolve-Pneumonia', 'Acute Kidney Injury-lie-Death', 'Bradycardia-observed-Obesity', 'Yin Deficiency-associated-Obesity', 'Obesity-associated-Yin Deficiency', 'Fabry Disease-stratified-Proteinuria', 'Weight Loss-obtain-Diabetes Mellitus', 'Weight Loss-obtain-Cardiovascular Diseases', 'Nervous System Diseases-trigger-Metabolic Diseases', 'Peripheral Nervous System Diseases-trigger-Metabolic Diseases', 'Pigmentation Disorders-differentiate-Melanoma', 'Melanoma-include-Pigmentation Disorders', 'Sarcopenia-fall-Fractures, Bone', 'Delirium-related-Death', 'Neoplasms-stimulated-Inflammation', 'Inflammation-associated-Wounds and Injuries', 'Wounds and Injuries-associated-Inflammation', 'Atrial Fibrillation-define-Disease', 'Dementia-differentiate-Alzheimer Disease', 'Alzheimer Disease-characterized-Amyloidosis', 'Alzheimer Disease-characterized-Tauopathies', 'Dementia-diagnose-Delirium', 'Femoral Neck Fractures-associated-Death', 'Death-associated-Femoral Neck Fractures', 'Gait Disorders, Neurologic-undergo-Back Pain', 'Diabetes Mellitus, Type 1-develop-Microvascular Angina', 'Diabetes Mellitus, Type 1-develop-Retinal Diseases', 'Diabetes Mellitus-increased-Dementia', 'Hyperandrogenism-resulted-Disease', 'Neurologic Manifestations-resulted-Disease', 'Disease-resulted-Polycystic Ovary Syndrome', 'Rheumatic Diseases-characterised-Pain', 'Polymyalgia Rheumatica-occur-Vasculitis', 'Death-link-Inflammation', 'Sleep Deprivation-mimic-Cerebral Infarction', 'Sleep Deprivation-randomize-Hypoxia', 'Cerebral Infarction-randomize-Hypoxia', 'Cerebral Infarction-randomize-Graft vs Host Disease', 'Calcinosis-increase-Atherosclerosis', 'Inflammation-exhibit-Chemical and Drug Induced Liver Injury', 'Inflammation-exhibit-Fibrosis', 'Alzheimer Disease-assumed-Arachnoid Cysts', 'Sleep Apnea, Obstructive-characterized-Apnea', 'Infections-represent-Bacterial Infections', 'Infections-represent-Death', 'Migraine Disorders-assessed-Dementia', 'Migraine Disorders-assessed-Alzheimer Disease', 'Dementia-include-Migraine Disorders', 'Alzheimer Disease-include-Migraine Disorders', 'Dementia, Vascular-include-Migraine Disorders', 'Parkinson Disease-result-Nerve Degeneration', 'Sarcopenia-include-Chronic Disease', 'Brain Injuries, Traumatic-defined-Coma', 'Brain Injuries, Traumatic-defined-Amnesia', 'Brain Injuries, Traumatic-defined-Unconsciousness', 'Dementia-triggered-Neurodegenerative Diseases', 'Brain Damage, Chronic-caused-Nerve Degeneration', 'Brain Damage, Chronic-lead-Memory Disorders', 'Brain Damage, Chronic-lead-Sleep Initiation and Maintenance Disorders', 'Nerve Degeneration-lead-Memory Disorders', 'Nerve Degeneration-lead-Sleep Initiation and Maintenance Disorders', 'Dementia-cause-Alzheimer Disease', 'Drug-Related Side Effects and Adverse Reactions-act-Skin Diseases', 'Hyperalgesia-cause-Neurodegenerative Diseases', 'Wounds and Injuries-cause-Neurodegenerative Diseases', 'Diabetes Mellitus-associate-Hypoglycemia', 'Hypoglycemia-associate-Diabetes Mellitus', 'Kidney Diseases-defined-Proteinuria', 'Kidney Diseases-associated-Stroke', 'Stroke-associated-Kidney Diseases', 'Kidney Diseases-associated-Coronary Artery Disease', 'Coronary Artery Disease-associated-Kidney Diseases', 'Respiratory Tract Diseases-studied-Pulmonary Disease, Chronic Obstructive', 'Respiratory Tract Diseases-studied-Lung Diseases, Interstitial', 'Respiratory Tract Diseases-studied-Supraglottitis', 'Neoplasms-associated-Lymphohistiocytosis, Hemophagocytic', 'Lymphohistiocytosis, Hemophagocytic-associated-Neoplasms', 'Inflammation-linked-Cardiovascular Diseases', 'Hemolytic-Uremic Syndrome-linked-Atherosclerosis', 'Hemolytic-Uremic Syndrome-linked-Cardiovascular Diseases', 'Pain-increase-Death', 'Muscular Atrophy-occur-Cardiovascular Diseases', 'Muscular Atrophy-occur-Diabetes Mellitus, Type 2', 'Drug-Related Side Effects and Adverse Reactions-include-Esophageal Stenosis', 'Pleural Effusion-include-Drug-Related Side Effects and Adverse Reactions', 'Pericardial Effusion-include-Drug-Related Side Effects and Adverse Reactions', 'Drug-Related Side Effects and Adverse Reactions-include-Esophageal Neoplasms', 'Drug-Related Side Effects and Adverse Reactions-include-Fistula', 'Drug-Related Side Effects and Adverse Reactions-include-Leukopenia', 'Atrial Fibrillation-limited-Anemia', 'Death-increase-Craniocerebral Trauma', 'Death-increase-Lung Injury', 'Inflammation-drive-Neurologic Manifestations', 'Death-increase-Neoplasm Metastasis', 'Neurologic Manifestations-play-Atherosclerosis', 'Neurologic Manifestations-established-Rupture', 'Mitochondrial Diseases-make-Drug-Related Side Effects and Adverse Reactions', 'Drug-Related Side Effects and Adverse Reactions-triggered-Mitochondrial Diseases', 'Heart Diseases-delay-Reperfusion Injury', 'Diabetes Mellitus-favor-Heart Failure', 'Atherosclerosis-favor-Heart Failure', 'Dementia-observed-Death', 'Urinary Incontinence-hide-Communicable Diseases', 'Skin Diseases-consist-Dermatitis', 'Atherosclerosis-linked-Inflammation', 'Dementia-survive-Wounds and Injuries', 'Anophthalmos-result-Vision Disorders', 'Death-recognize-Heart Failure', 'Neoplasms-result-Fibrosis', 'Neoplasms-result-Neurodegenerative Diseases', 'Fractures, Bone-maintain-Hypotension', 'Communicable Diseases-include-HIV Infections', 'Communicable Diseases-live-HIV Infections', 'Vision, Low-recommend-Neoplasms', 'Vision, Low-publish-Death', 'Neoplasms-recommend-Death', 'Myocardial Infarction-turn-Back Pain', 'AIDS Arteritis, Central Nervous System-distinguish-Alzheimer Disease', 'Metabolic Syndrome-linked-Alzheimer Disease', 'Gait Disorders, Neurologic-related-Heredodegenerative Disorders, Nervous System', 'Breast Neoplasms-estimate-Neoplasms', 'Muscular Atrophy-exacerbated-Parkinson Disease', 'Muscular Atrophy-consider-Parkinson Disease', 'Cataract-sever-Corneal Diseases', 'Cataract-aggravate-Headache Disorders, Secondary', 'Corneal Diseases-aggravate-Headache Disorders, Secondary', 'Neoplasms-associated-Lung Diseases, Interstitial', 'Lung Diseases, Interstitial-associated-Neoplasms', 'Polymyositis-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-Polymyositis', 'Diabetes Mellitus-observed-Polymyositis', 'Diabetes Mellitus-observed-Dermatomyositis', 'Diabetes Mellitus-observed-Neoplasms', 'Dermatomyositis-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-Dermatomyositis', 'Muscular Dystrophy, Duchenne-feature-Muscular Atrophy', 'Muscular Dystrophy, Duchenne-feature-Respiratory Insufficiency', 'Muscular Dystrophy, Duchenne-feature-Cardiomyopathies', 'HIV Infections-treat-Nervous System Diseases', 'Obesity-included-Weight Loss', 'Obesity-attenuate-Muscular Atrophy', 'Muscular Atrophy-observe-Obesity', 'Polyradiculopathy-challenge-Spinal Stenosis', 'Osteophyte-associated-Osteochondritis', 'Osteochondritis-associated-Osteophyte', 'Pulmonary Arterial Hypertension-treat-Hypotension', 'Inflammatory Bowel Diseases-receive-Drug-Related Side Effects and Adverse Reactions', 'HIV Infections-increase-Death', 'HIV Infections-determined-Death', 'Death-attributed-Death, Sudden', 'Death-attributed-HIV Infections', 'Neoplasms-related-Acquired Immunodeficiency Syndrome', 'Erectile Dysfunction-associated-Neoplasms', 'Neoplasms-associated-Erectile Dysfunction', 'Erectile Dysfunction-associated-Coronary Artery Disease', 'Coronary Artery Disease-associated-Erectile Dysfunction', 'Diabetes Mellitus-contract-Hepatitis B', 'Hepatitis B-reduce-Diabetes Mellitus', 'Deglutition Disorders-associated-Weight Loss', 'Weight Loss-associated-Deglutition Disorders', 'Neoplasms-provide-Stomach Neoplasms', 'Hypertension-treat-Cardiovascular Diseases', 'Thoracic Outlet Syndrome-blunted-Atrial Fibrillation', 'Thoracic Outlet Syndrome-blunted-Hypertension', 'Stroke-increased-Atrial Fibrillation', 'Obesity-induce-Weight Loss', 'Obesity-improve-Glucose Metabolism Disorders', 'Weight Loss-improve-Glucose Metabolism Disorders', 'Memory Disorders-caused-Diabetes Mellitus', 'Diabetes Mellitus-caused-Alzheimer Disease', 'Pain-remain-Fractures, Bone', 'Neoplasms-fit-Seizures', 'Pulmonary Disease, Chronic Obstructive-characterized-Signs and Symptoms, Respiratory', 'Lung Diseases-characterized-Signs and Symptoms, Respiratory', 'Meningitis, Bacterial-affected-HIV Infections', 'Respiratory Insufficiency-increasing-Liver Diseases', 'Respiratory Insufficiency-increasing-Acute Kidney Injury', 'Nervous System Diseases-increasing-Liver Diseases', 'Nervous System Diseases-increasing-Acute Kidney Injury', 'Sepsis-increasing-Liver Diseases', 'Sepsis-increasing-Acute Kidney Injury', 'Fractures, Bone-assess-Sarcopenia', 'Muscle Weakness-associated-Cardiac Output, Low', 'Cardiac Output, Low-associated-Muscle Weakness', 'Osteoporosis-recommended-Fractures, Bone', 'Fractures, Bone-carried-Sarcopenia', 'Arteriovenous Fistula-compare-Fistula', 'Death-estimated-Neoplasms', 'Breast Neoplasms-associated-Fatigue', 'Fatigue-associated-Breast Neoplasms', 'Deglutition Disorders-estimate-Dementia', 'Death-seen-Thalassemia', 'Hepatomegaly-contribute-Hyperinsulinism', 'Weight Gain-contribute-Hyperinsulinism', 'Bone Diseases, Metabolic-contribute-Osteoporosis', 'Tremor-followed-Dystonia', 'Tremor-followed-Hemifacial Spasm', 'Dystonia-followed-Hemifacial Spasm', 'Gait Disorders, Neurologic-include-Tremor', 'Fibrosis-include-Fatty Liver', 'Carcinoma, Hepatocellular-include-Fatty Liver', 'Carcinoma, Hepatocellular-influenced-Fatty Liver', 'Endotoxemia-proposed-Inflammation', 'Endotoxemia-associated-Dementia', 'Dementia-associated-Endotoxemia', 'Neoplasms-facilitate-Seizures', 'Seizures-facilitate-Neoplasms', 'Obesity-associated-Vascular Calcification', 'Vascular Calcification-associated-Obesity', 'Diabetes Mellitus, Type 2-associated-Vascular Calcification', 'Vascular Calcification-associated-Diabetes Mellitus, Type 2', 'Pain-need-Dementia', 'Pain-need-Delirium', 'Atrial Fibrillation-predict-Cardiovascular Diseases', 'Inflammation-drive-Cardiovascular Diseases', 'Neoplasms-occur-Hyperglycemia', 'Intellectual Disability-reduce-Neurodegenerative Diseases', 'Intellectual Disability-reduce-Neoplasms', 'Dysplastic Nevus Syndrome-accompanied-Pancreatic Cyst', 'Dementia-target-Neurotoxicity Syndromes', 'Neurotoxicity Syndromes-fail-Alzheimer Disease', 'Neurotoxicity Syndromes-produce-Alzheimer Disease', 'Death-prevent-Alzheimer Disease', 'Death-prevent-Dementia, Vascular', 'Inflammation-implicated-Cerebral Hemorrhage', 'Pelvic Neoplasms-include-Arcus Senilis', 'Pain-addressed-Neoplasms', 'Pain-mitigate-Drug-Related Side Effects and Adverse Reactions', 'Neoplasms-mitigate-Drug-Related Side Effects and Adverse Reactions', 'Cerebral Hemorrhage-inhibit-Nervous System Malformations', 'Cerebral Hemorrhage-inhibit-Malformations of Cortical Development, Group I', 'Nervous System Malformations-inhibit-Malformations of Cortical Development, Group I', 'Optic Nerve Diseases-associated-Ocular Hypertension', 'Ocular Hypertension-associated-Optic Nerve Diseases', 'Diabetes Mellitus-admitted-Meningitis', 'Carotid Artery Diseases-investigate-Cardiovascular Diseases', 'Carotid Artery Diseases-investigate-Hearing Loss', 'Pulmonary Disease, Chronic Obstructive-compare-Lung Diseases', 'Cerebral Hemorrhage-obtained-Tauopathies', 'Mitochondrial Diseases-accelerate-Lupus Erythematosus, Systemic', 'Cardiovascular Abnormalities-accelerate-Lupus Erythematosus, Systemic', 'Cardiovascular Diseases-inflammage-Lupus Erythematosus, Systemic', 'Cardiovascular Diseases-reviewed-Mitochondrial Diseases', 'Cardiovascular Diseases-inflammage-Mitochondrial Diseases', 'Lupus Erythematosus, Systemic-reviewed-Mitochondrial Diseases', 'Lupus Erythematosus, Systemic-inflammage-Mitochondrial Diseases', 'Neoplasms-frame-Wounds and Injuries', 'Death-increasing-Sarcoidosis', 'Cardiomyopathies-defined-Hypotension', 'Cardiomyopathies-peak-Hypotension', 'Infarction-include-Heart Valve Diseases', 'Arthritis-associated-Disorders of Excessive Somnolence', 'Disorders of Excessive Somnolence-associated-Arthritis', 'Restless Legs Syndrome-associated-Disorders of Excessive Somnolence', 'Disorders of Excessive Somnolence-associated-Restless Legs Syndrome', 'Sleep Wake Disorders-associated-Disorders of Excessive Somnolence', 'Disorders of Excessive Somnolence-associated-Sleep Wake Disorders', 'Sepsis-demonstrate-Inflammation', 'Alzheimer Disease-related-Inflammation', 'Angina Pectoris-include-Cardiovascular Diseases', 'AIDS Arteritis, Central Nervous System-prevent-Neurotoxicity Syndromes', 'Infections-rise-Respiratory Tract Diseases', 'Bronchiolitis-cause-Respiratory Tract Diseases', 'Ossification of Posterior Longitudinal Ligament-shown-Peripheral Arterial Disease', 'Neoplasms-present-Vomiting', 'Neoplasms-present-Sleep Initiation and Maintenance Disorders', 'Inflammation-appear-Prostatic Hyperplasia', 'Vascular Calcification-accelerated-Renal Insufficiency, Chronic', 'Inflammation-contribute-Vascular Calcification', 'Blindness-protect-Wounds and Injuries', 'Infections-increase-Seizures', 'Amyloidosis-play-Neurodegenerative Diseases', 'Neurodegenerative Diseases-treat-Alzheimer Disease', 'Osteoporosis-organize-Musculoskeletal Diseases', 'Sepsis-identified-Seizures', 'Arrhythmias, Cardiac-identified-Seizures', 'Parkinson Disease-differentiate-Parkinson Disease, Secondary', 'Parkinson Disease-differentiate-Tremor', 'Parkinson Disease-differentiate-Immunologic Deficiency Syndromes', 'Neoplasms-defined-Neoplasm Metastasis', 'Neoplasms-defined-Urinary Bladder Neoplasms', 'Neoplasms-show-Urinary Bladder Neoplasms', 'Neoplasm Metastasis-show-Urinary Bladder Neoplasms', 'Mitochondrial Diseases-include-HIV Infections', 'Metabolic Diseases-include-HIV Infections', 'Death-documented-Neoplasms', 'Death-documented-Heart Diseases', 'Death-documented-Cerebrovascular Disorders', 'Diabetes Mellitus-related-Death', 'Osteoporosis-related-Death', 'Osteoporosis-related-Neoplasms', 'Anorexia-include-Gastrointestinal Diseases', 'Osteoporosis-increase-Heart Failure', 'Hypotension, Orthostatic-associated-Heart Failure', 'Heart Failure-associated-Hypotension, Orthostatic', 'Death-occur-Multiple Organ Failure', 'Death-associated-Amyloidosis', 'Amyloidosis-associated-Death', 'Multiple Organ Failure-associated-Amyloidosis', 'Amyloidosis-associated-Multiple Organ Failure', 'Epilepsy-treat-Obesity', 'Epilepsy-treat-Diabetes Mellitus', 'Osteoporosis-correlated-Hantavirus Pulmonary Syndrome', 'Neuroma, Acoustic-diagnose-Neoplasms', 'Neurodegenerative Diseases-linked-Inflammation', 'Hypertension, Pulmonary-associated-Death', 'Death-associated-Hypertension, Pulmonary', 'Huntington Disease-implicated-Neurodegenerative Diseases', 'Breast Neoplasms-estimated-Death', 'Osteoporosis-affect-Fractures, Bone', 'Osteoporosis-lead-Hip Fractures', 'Sleep Initiation and Maintenance Disorders-result-Coronary Artery Disease', 'Sleep Initiation and Maintenance Disorders-result-Myocardial Infarction', 'Sleep Initiation and Maintenance Disorders-result-Arrhythmias, Cardiac', 'Sleep Initiation and Maintenance Disorders-result-Atrial Fibrillation', 'Coronary Artery Disease-result-Diabetes Mellitus', 'Myocardial Infarction-result-Diabetes Mellitus', 'Atrial Fibrillation-result-Diabetes Mellitus', 'Neoplasms-recommend-Dyspnea', 'Neoplasms-improve-Dyspnea', 'Cerebral Amyloid Angiopathy-occur-Alzheimer Disease', 'Neoplasms-identified-Fatigue', 'Death-include-Anemia', 'Death-identified-Anemia', 'Liver Failure-generate-Inflammation', 'Liver Failure-induce-Necrosis', 'Liver Failure, Acute-generate-Inflammation', 'Liver Failure, Acute-induce-Necrosis', 'Inflammation-induce-Necrosis', 'HIV Infections-associated-Leukemia, B-Cell', 'Leukemia, B-Cell-associated-HIV Infections', 'Lymphoma, Non-Hodgkin-constitute-Lymphoproliferative Disorders', 'Obesity, Abdominal-correlated-Cardiovascular Diseases', 'HIV Infections-treat-Death', 'Chronic Disease-contribute-Fragile X Syndrome', 'Fragile X Syndrome-contribute-Bone Diseases', 'End Stage Liver Disease-cause-Death', 'End Stage Liver Disease-cause-Infections', 'Sexual Dysfunction, Physiological-associated-Dyspareunia', 'Dyspareunia-associated-Sexual Dysfunction, Physiological', 'Death-cause-Infections', 'Dyspareunia-reported-Pain', 'Neoplasms-assess-Skin Diseases', 'Neoplasms-assess-Infections', 'Bacterial Infections-associated-Stomach Neoplasms', 'Stomach Neoplasms-associated-Bacterial Infections', 'Gastritis-investigate-Ulcer', 'Prostatitis-emerging-Postpartum Hemorrhage', 'Neoplasms-described-Melanoma', 'Hypoglycemia-take-Diabetes Mellitus', 'Urinary Incontinence, Stress-associated-Atrophic Vaginitis', 'Atrophic Vaginitis-associated-Urinary Incontinence, Stress', 'Urinary Incontinence, Stress-associated-Pelvic Pain', 'Pelvic Pain-associated-Urinary Incontinence, Stress', 'Urinary Incontinence, Stress-associated-Constipation', 'Constipation-associated-Urinary Incontinence, Stress', 'Urinary Incontinence, Stress-associated-Urinary Incontinence', 'Urinary Incontinence-associated-Urinary Incontinence, Stress', 'Cerebral Infarction-worsen-Heart Failure', 'Atherosclerosis-promote-Aneurysm', 'Diabetes Mellitus-defined-Metabolic Syndrome', 'Seizures-associated-Hypercapnia', 'Hypercapnia-associated-Seizures', 'Scoliosis-managed-Spinal Stenosis', 'Hypotension, Orthostatic-tend-Leukoencephalopathies', 'Neoplasms-enter-Drug-Related Side Effects and Adverse Reactions', 'Pain-increase-Dementia', 'Pain-associated-Arthritis, Rheumatoid', 'Arthritis, Rheumatoid-associated-Pain', 'Musculoskeletal Diseases-associated-Sarcopenia', 'Sarcopenia-associated-Musculoskeletal Diseases', 'Musculoskeletal Diseases-associated-Osteoporosis', 'Osteoporosis-associated-Musculoskeletal Diseases', 'Musculoskeletal Diseases-associated-Osteoarthritis', 'Osteoarthritis-associated-Musculoskeletal Diseases', 'Fractures, Open-related-Hearing Loss', 'Pulmonary Disease, Chronic Obstructive-remain-Death', 'Cerebral Amyloid Angiopathy-exhibit-Alzheimer Disease', 'Melanoma-develop-Neoplasms', 'Death-affect-Heredodegenerative Disorders, Nervous System', 'Airway Obstruction-lead-Death', 'Inflammation-associated-Asthma', 'Asthma-associated-Inflammation', 'Carcinoma, Hepatocellular-represent-Neoplasms', 'Diabetes Mellitus-followed-Renal Insufficiency', 'Pancreatic Neoplasms-suffer-Liver Diseases', 'Pain-include-Mouth Diseases', 'Sepsis-include-Mouth Diseases', 'Inflammation-associated-Autoimmune Diseases', 'Autoimmune Diseases-associated-Inflammation', 'Intracranial Arterial Diseases-associated-Autoimmune Diseases', 'Autoimmune Diseases-associated-Intracranial Arterial Diseases', 'Inflammation-play-Intracranial Arterial Diseases', 'Atrial Fibrillation-cause-Arrhythmias, Cardiac', 'Atrial Fibrillation-cause-Cardiovascular Diseases', 'Supranuclear Palsy, Progressive-differentiated-Parkinson Disease', 'Adrenal Insufficiency-treat-Pain', 'Coronary Artery Disease-lead-Myocardial Infarction', 'Coronary Artery Disease-occur-Heart Arrest', 'Diabetes Mellitus-experience-Hyperglycemia', 'Myocardial Infarction-lead-Atherosclerosis', 'Myocardial Infarction-lead-Shock, Septic', 'Diabetes Mellitus, Type 2-recognized-Neoplasms', 'Myocardial Infarction-lead-Reperfusion Injury', 'Myocardial Infarction-occur-Heart Arrest', 'Atherosclerosis-focus-Shock, Septic', 'Atherosclerosis-occur-Heart Arrest', 'Shock, Septic-occur-Heart Arrest', 'Reperfusion Injury-occur-Heart Arrest', 'Diabetes Mellitus-reported-Huntington Disease', 'Diabetes Mellitus-reported-Genetic Diseases, Inborn', 'Huntington Disease-exhibit-Chorea', 'Huntington Disease-exhibit-Protein-Energy Malnutrition', 'Chorea-exhibit-Protein-Energy Malnutrition', 'Renal Insufficiency, Chronic-affect-Diabetes Mellitus', 'Sarcopenia-caused-Neuromuscular Diseases', 'Metabolic Diseases-increase-Dyslipidemias', 'Sarcopenia-quantify-Prostatic Neoplasms', 'Death-caused-Adrenal Insufficiency', 'Neoplasms-rise-Spinal Cord Diseases', 'Blood Coagulation Disorders-include-Death', 'Bradycardia-occur-Atrioventricular Block', 'Nocturia-include-Death', 'Nocturia-include-Fractures, Bone', 'Osteoporosis-associate-Fractures, Bone', 'Fractures, Bone-associate-Osteoporosis', 'Aneurysm-remain-Fractures, Bone', 'Osteoporosis-remain-Fractures, Bone', 'Aneurysm-performed-Fractures, Bone', 'Aneurysm-identify-Osteoporosis', 'Appendiceal Neoplasms-cross-reference-Appendicitis', 'Hemorrhage-reduce-Ischemia', 'Neoplasms-used-Urinary Bladder Neoplasms', 'Arbovirus Infections-classified-Headache Disorders, Secondary', 'Hip Fractures-hospitalized-Pain', 'Iliac Aneurysm-suffer-Hip Fractures', 'Arthritis, Rheumatoid-evaluate-Erectile Dysfunction', 'Atrial Fibrillation-pave-Heart Diseases', 'Atrial Fibrillation-include-Heart Diseases', 'Carotid Stenosis-include-Carotid Artery Diseases', 'Carotid Stenosis-associated-Dementia', 'Dementia-associated-Carotid Stenosis', 'Carotid Artery Diseases-include-Arteriosclerosis', 'Carotid Artery Diseases-include-Diabetes Mellitus', 'Carotid Artery Diseases-include-Stroke', 'Sarcopenia-performed-Ataxia', 'Fasciculation-characterized-Muscular Atrophy', 'Cerebral Infarction-represent-Death', 'Stroke-lost-Infarction', 'Brugada Syndrome-unmasked-Infections', 'Joint Diseases-remain-Hemophilia A', 'Hemorrhage-remain-Hemophilia A', 'Infections-occur-Chemical and Drug Induced Liver Injury', 'Chemical and Drug Induced Liver Injury-occur-Death', 'Pulmonary Disease, Chronic Obstructive-improve-Dyspnea', 'Stroke-associated-Dyspnea', 'Dyspnea-associated-Stroke', 'Fractures, Bone-improve-Pain', 'Hemolytic-Uremic Syndrome-associated-Death', 'Death-associated-Hemolytic-Uremic Syndrome', 'Atherosclerosis-play-Neurodegenerative Diseases', 'Infarction-play-Neurodegenerative Diseases', 'Osteoarthritis-characterized-Bone Cysts', 'Osteoarthritis-characterized-Synovitis', 'Infections-investigated-Gastritis', 'Thrombosis-caused-Hypertension', 'Wounds and Injuries-result-Nerve Degeneration', 'Wounds and Injuries-lead-Nerve Degeneration', 'Stroke-result-Nerve Degeneration', 'Stroke-lead-Nerve Degeneration', 'Diabetes Mellitus-associated-Gait Disorders, Neurologic', 'Gait Disorders, Neurologic-associated-Diabetes Mellitus', 'Diabetes Mellitus-suggest-Gait Disorders, Neurologic', 'Death-co-occur-Multiple Organ Failure', 'Osteoarthritis-used-Cartilage Diseases', 'Osteoarthritis-test-Cartilage Diseases', 'Aortic Valve Stenosis-diagnosed-Neoplasms', 'Pain-contribute-Psychomotor Agitation', 'Mesothelioma-disturbed-Carcinogenesis', 'Death-exhibit-Muscular Atrophy', 'Death-exhibit-Sarcopenia', 'Muscular Atrophy-exhibit-Sarcopenia', 'Diabetes Mellitus-render-Breast Neoplasms', 'Breast Neoplasms-use-Neoplasms', 'Atrial Fibrillation-balance-Embolism', 'Atrial Fibrillation-balance-Hemorrhage', 'Microvascular Angina-associated-Peripheral Arterial Disease', 'Peripheral Arterial Disease-associated-Microvascular Angina', 'Infections-include-Postoperative Complications', 'Postoperative Complications-require-Stroke', 'Infections-require-Stroke', 'Renal Insufficiency-require-Stroke', 'Hypotension-correlate-Hypertension', 'Hypotension-correlate-Prostatic Hyperplasia', 'Hypertension-correlate-Prostatic Hyperplasia', 'Hypertension-include-Prostatic Hyperplasia', 'Glucose Intolerance-associated-Hypertension', 'Hypertension-associated-Glucose Intolerance', 'Diabetes Mellitus, Type 2-associate-Hypertension', 'Hypertension-associate-Diabetes Mellitus, Type 2', 'Glucose Intolerance-associate-Hypertension', 'Hypertension-associate-Glucose Intolerance', 'Neoplasms-misdiagnosed-Hematoma, Subdural', 'Postoperative Cognitive Complications-include-Drug-Related Side Effects and Adverse Reactions', 'Sarcopenia-exacerbate-Obesity', 'Osteoporosis-occur-Fractures, Bone', 'Ovarian Diseases-treat-Ovarian Neoplasms', 'Inflammation-cause-Diabetes Mellitus', "Sister Mary Joseph's Nodule-develop-Peritoneal Neoplasms", "Sister Mary Joseph's Nodule-develop-Lymphatic Diseases", 'Peritoneal Neoplasms-develop-Neoplasm Metastasis', 'Lymphatic Diseases-develop-Neoplasm Metastasis', 'Neoplasms-spread-Lymphatic Diseases', 'Death-observed-Alzheimer Disease', 'Cardiovascular Diseases-demonstrate-Atherosclerosis', 'Chemical and Drug Induced Liver Injury-cause-Asthma', 'Chemical and Drug Induced Liver Injury-induce-Migraine Disorders', 'Chemical and Drug Induced Liver Injury-promote-Obesity', 'Asthma-induce-Migraine Disorders', 'Asthma-promote-Obesity', 'Migraine Disorders-promote-Obesity', 'Death-compare-Obesity', 'Infections-cause-Sepsis', 'Infections-cause-Stillbirth', 'Ischemia-prevent-Muscular Dystrophies', 'Peripheral Arterial Disease-include-Cardiovascular Diseases', 'Hyphema-reveal-Vitreous Hemorrhage', 'Glaucoma-control-Ocular Hypertension', 'Low Back Pain-defined-Neuralgia', 'Inflammation-cause-Drug Hypersensitivity', 'Pulmonary Disease, Chronic Obstructive-identified-Death', 'Pulmonary Disease, Chronic Obstructive-suggest-Lung Diseases', 'Anemia-predispose-Stroke', 'Cerebrovascular Disorders-suggest-Hyperemia', 'Venous Thromboembolism-include-Venous Thrombosis', 'Thrombosis-include-Venous Thromboembolism', 'Venous Thrombosis-include-Thrombosis', 'Hematologic Diseases-propagate-Venous Thromboembolism', 'Venous Thrombosis-lead-Inflammation', 'Venous Thromboembolism-include-Neoplasms', 'Venous Thromboembolism-include-Wounds and Injuries', 'Venous Thromboembolism-include-Sepsis', 'Venous Thromboembolism-include-Inflammatory Bowel Diseases', 'Venous Thromboembolism-include-Paralysis', 'Lymphoma-classified-Hodgkin Disease', 'Iatrogenic Disease-associated-Immunologic Deficiency Syndromes', 'Immunologic Deficiency Syndromes-associated-Iatrogenic Disease', 'Alzheimer Disease-increase-Arrhythmias, Cardiac', 'Progeria-present-Cardiovascular Diseases', 'Heart Arrest-induced-Neoplasms', 'Breast Neoplasms-examine-Drug-Related Side Effects and Adverse Reactions', 'Cerebral Small Vessel Diseases-related-Arteriolosclerosis', 'Acute Kidney Injury-manifested-Nausea', 'Acute Kidney Injury-manifested-Vomiting', 'Death-given-Lung Diseases, Obstructive', 'Acute Kidney Injury-become-Chronic Disease', 'Acute Kidney Injury-become-Drug-Related Side Effects and Adverse Reactions', 'Acute Kidney Injury-become-Infections', 'Infections-prevent-Catastrophic Illness', 'Osteolysis-prevent-Catastrophic Illness', 'Bone Neoplasms-prevent-Catastrophic Illness', 'Cardiac Output, Low-cause-Cerebrovascular Disorders', 'Neoplasms-accelerate-Carcinogenesis', 'Weight Loss-balanced-Malnutrition', 'Obesity-balanced-Malnutrition', 'Diabetes Mellitus, Type 2-balanced-Malnutrition', 'Coma-decrease-Death', 'Diabetes Mellitus, Type 2-considered-Cardiovascular Diseases', 'Inflammatory Bowel Diseases-stop-Hypertension', 'Diabetes Mellitus-determined-Hepatitis B, Chronic', 'Hypertension-determined-Hepatitis B, Chronic', 'Renal Insufficiency, Chronic-determined-Hepatitis B, Chronic', 'Bone Diseases, Metabolic-determined-Hepatitis B, Chronic', 'Osteoporosis-determined-Hepatitis B, Chronic', 'Cushing Syndrome-ameliorate-Heart Diseases', 'Neoplasms-related-Werner Syndrome', 'Carcinoma, Squamous Cell-arise-Werner Syndrome', 'Drug-Related Side Effects and Adverse Reactions-associated-Neurodegenerative Diseases', 'Neurodegenerative Diseases-associated-Drug-Related Side Effects and Adverse Reactions', 'Dementia-measure-Atrophy', 'Alzheimer Disease-measured-Atrophy', 'Cervical Intraepithelial Neoplasia-recapitulated-Neoplasms', 'Carcinoma, Pancreatic Ductal-generated-Neoplasms', 'Chronic Disease-reveal-Seizures', 'Osteoarthritis-marked-Inflammation', 'Osteoarthritis-arise-Synovitis', 'Osteoarthritis-arise-Joint Diseases', 'Osteoarthritis-marked-Pain', 'Inflammation-arise-Synovitis', 'Inflammation-arise-Joint Diseases', 'Iatrogenic Disease-account-Lymphedema', 'Genetic Diseases, Inborn-account-Lymphedema', 'Lymphatic Diseases-result-Wounds and Injuries', 'Lymphatic Diseases-result-Parasitic Diseases', 'Lymphatic Diseases-result-Iatrogenic Disease', 'Hematologic Diseases-remain-Anemia', 'Obesity-associated-Cushing Syndrome', 'Cushing Syndrome-associated-Obesity', 'Hemorrhage-identify-Venous Thromboembolism', 'Thrombocytopenia-associated-Hemorrhage', 'Hemorrhage-associated-Thrombocytopenia', 'Inflammation-include-Fatty Liver', 'Takotsubo Cardiomyopathy-include-Fatty Liver', 'Inflammation-include-Chronic Disease', 'Liver Cirrhosis-include-Fatty Liver', 'Parkinson Disease-include-Heredodegenerative Disorders, Nervous System', 'Multiple Sclerosis-include-Heredodegenerative Disorders, Nervous System', 'Amyotrophic Lateral Sclerosis-include-Heredodegenerative Disorders, Nervous System', 'Huntington Disease-include-Heredodegenerative Disorders, Nervous System', 'Restless Legs Syndrome-include-Heredodegenerative Disorders, Nervous System', 'Spinal Cord Injuries-include-Heredodegenerative Disorders, Nervous System', 'Ataxia-include-Heredodegenerative Disorders, Nervous System', 'Sarcopenia-evaluate-Lung Neoplasms', 'Glioblastoma-feature-Nervous System Diseases', 'Liver Diseases-compensate-Fibrosis', 'Mastocytosis, Systemic-cause-Fractures, Bone', 'Mitochondrial Diseases-underlie-Neurologic Manifestations', 'Bone Diseases, Metabolic-become-Fractures, Bone', 'Bone Diseases, Metabolic-result-Osteoporosis', 'Fractures, Bone-result-Osteoporosis', 'Coronary Artery Disease-identified-Myocardial Infarction', 'Coronary Artery Disease-identified-Angina Pectoris', 'Prostatic Neoplasms-increasing-Death', 'Prostatic Neoplasms-impact-Death', 'Hallucinations-include-Death', 'Hallucinations-include-Infections', 'Hallucinations-used-Infections', 'Blindness-present-Glaucoma', 'Alcoholism-associated-West Nile Fever', 'West Nile Fever-associated-Alcoholism', 'Diabetes Mellitus-associated-West Nile Fever', 'West Nile Fever-associated-Diabetes Mellitus', 'Communicable Diseases-consider-Meningitis, Aseptic', 'Communicable Diseases-consider-Encephalitis', 'Pelvic Inflammatory Disease-identified-Infections', 'Arbovirus Infections-cause-Nervous System Diseases', 'Communicable Diseases-consider-Paralysis', 'Arbovirus Infections-cause-Encephalitis', 'Intestinal Atresia-develop-Fever', 'Intestinal Atresia-develop-Tremor', 'Intestinal Atresia-develop-Paralysis', 'Alzheimer Disease-link-AIDS Arteritis, Central Nervous System', 'Inflammation-link-AIDS Arteritis, Central Nervous System', 'Glucosephosphate Dehydrogenase Deficiency-protect-Cerebrovascular Disorders', 'Ovarian Diseases-occur-Uremia', 'Glucosephosphate Dehydrogenase Deficiency-protect-Colorectal Neoplasms', 'Genetic Diseases, Inborn-protect-Cerebrovascular Disorders', 'Genetic Diseases, Inborn-protect-Colorectal Neoplasms', 'Mitochondrial Diseases-contribute-Neoplasms', 'Autoimmune Diseases-characterized-Thrombosis', 'Inflammation-associated-Antiphospholipid Syndrome', 'Antiphospholipid Syndrome-associated-Inflammation', 'Alzheimer Disease-upregulated-Neurodegenerative Diseases', 'Intervertebral Disc Degeneration-associated-Inflammation', 'Inflammation-associated-Intervertebral Disc Degeneration', 'Vision Disorders-live-Dementia', 'Death-evaluate-Hematoma, Subdural, Chronic', 'Hematoma, Subdural, Chronic-included-Death', 'Glaucoma-lead-Blindness', 'Wounds and Injuries-followed-Death', 'Neurologic Manifestations-play-Thoracic Outlet Syndrome', 'Fractures, Bone-confined-Hypertension', 'Nervous System Diseases-focus-Neurologic Manifestations', 'Neoplasms-observe-Skin Neoplasms', 'Sarcopenia-associated-Stroke', 'Stroke-associated-Sarcopenia', 'Sarcopenia-suffer-Stroke', 'Stroke-show-Sarcopenia', 'Sarcopenia-detect-Stroke', 'Sarcopenia-show-Diabetes Mellitus, Type 2', 'Streptococcal Infections-necrotise-Fasciitis', 'Leukemia, Myeloid, Acute-include-Bone Marrow Failure Disorders', 'Wounds and Injuries-include-Vision, Low', 'Wounds and Injuries-include-Hearing Loss', 'Breast Neoplasms-make-Drug-Related Side Effects and Adverse Reactions', 'Cardiomyopathies-include-Retinal Degeneration', 'Respiratory Insufficiency-include-Retinal Degeneration', 'Muscular Dystrophy, Duchenne-make-Ischemia', 'Infections-present-Stroke', 'Muscular Dystrophy, Duchenne-detect-Retinal Diseases', 'Muscular Dystrophy, Duchenne-prevent-Vision Disorders', 'Retinal Diseases-prevent-Vision Disorders', 'Pregnancy Complications, Infectious-develop-Stroke', 'Muscular Dystrophy, Duchenne-experience-Retinitis', 'Muscular Dystrophy, Duchenne-experience-Retinal Neovascularization', 'Critical Illness-show-Chronic Pain', 'Inflammation-maintain-Colonic Neoplasms', 'Stroke-maintain-Inflammation', 'Stroke-follow-Colonic Neoplasms', 'Stroke-maintain-Colonic Neoplasms', 'Necrosis-facilitate-Stroke', 'Cerebral Infarction-compare-Bacterial Infections', 'Stroke-compare-Bacterial Infections', 'Acute Kidney Injury-followed-Kidney Diseases', 'Acute Kidney Injury-followed-Lupus Nephritis', 'Lupus Nephritis-followed-Kidney Diseases', 'Scabies-account-Pain', 'Scabies-account-Infections', 'Death-account-Pain', 'Death-account-Infections', 'Diabetes Mellitus-include-Vasculitis', 'Diabetes Mellitus-promote-Inflammation', 'Infections-base-Communicable Diseases', 'Infections-moderate-Communicable Diseases', 'Peritoneal Neoplasms-include-Blepharitis', 'Peritoneal Neoplasms-include-Dry Eye Syndromes', 'Adenoma, Pleomorphic-arise-Adenoma', 'Corneal Diseases-affect-Keratitis', 'Corneal Diseases-affect-Peritoneal Neoplasms', 'Keratitis-affect-Peritoneal Neoplasms', 'Renal Insufficiency, Chronic-favor-Diabetes Mellitus', 'Dyslipidemias-associated-Angina Pectoris', 'Angina Pectoris-associated-Dyslipidemias', 'Coronary Stenosis-associated-Angina Pectoris', 'Angina Pectoris-associated-Coronary Stenosis', 'Coronary Vasospasm-associated-Angina Pectoris', 'Angina Pectoris-associated-Coronary Vasospasm', 'Carcinoma, Non-Small-Cell Lung-compare-Pulmonary Disease, Chronic Obstructive', 'Alzheimer Disease-experience-Dementia', 'Alzheimer Disease-experience-Fractures, Bone', 'Dementia-experience-Fractures, Bone', 'Bone Marrow Diseases-approved-Hypotension', 'Cerebral Infarction-include-Neurodegenerative Diseases', 'Atherosclerosis-lead-Cerebrovascular Disorders', 'Hypertension-lead-Cerebrovascular Disorders', 'Cardiovascular Diseases-lead-Cerebrovascular Disorders', 'Inflammation-involve-Cerebrovascular Disorders', 'Stroke-decrease-Hemorrhage', 'Stroke-outweigh-Hemorrhage', 'Sarcopenia-included-Obesity', 'Inflammation-become-Obesity', 'Inflammation-involved-Sarcopenia', 'Inflammation-involved-Osteoporosis', 'Inflammation-involved-Neoplasms', 'Inflammation-implicated-Stroke', 'Inflammation-implicated-Cerebral Small Vessel Diseases', 'Cerebral Small Vessel Diseases-reveal-Stroke', 'Inflammation-reveal-Stroke', 'Inflammation-predict-Cerebral Small Vessel Diseases', 'Inflammation-related-Cerebral Small Vessel Diseases', 'Inflammation-tend-Cerebral Small Vessel Diseases', 'Inflammation-associated-Cerebral Small Vessel Diseases', 'Cerebral Small Vessel Diseases-associated-Inflammation', 'Inflammation-tend-Hypertension', 'Inflammation-tend-Aneurysm', 'Cerebral Small Vessel Diseases-involved-Aneurysm', 'Inflammation-involved-Aneurysm', 'Spinal Dysraphism-elucidate-Fecal Incontinence', 'Hypertension-elucidate-Fecal Incontinence', 'Pain-elucidate-Fecal Incontinence', 'Sarcopenia-potentiated-Inflammation', 'Neurogenic Bowel-elucidate-Fecal Incontinence', 'Fecal Incontinence-elucidate-Hydrocephalus', 'Nocturia-define-Polyuria', 'Emphysema-include-Multiple Organ Failure', 'Airway Obstruction-include-Multiple Organ Failure', 'Inflammation-include-Multiple Organ Failure', 'Proteostasis Deficiencies-include-Multiple Organ Failure', 'Inflammation-contribute-Emphysema', 'Parkinson Disease-provide-Agnosia', 'Musculoskeletal Diseases-lead-Back Pain', 'Renal Insufficiency-fall-Fractures, Bone', 'Sarcopenia-seen-Deglutition Disorders', 'Alzheimer Disease-seen-Deglutition Disorders', 'Sarcopenia-found-Deglutition Disorders', 'Sarcopenia-found-Alzheimer Disease', 'Alzheimer Disease-screened-Deglutition Disorders', 'Sarcopenia-screened-Deglutition Disorders', 'Sarcopenia-generalise-Death', 'Fasciculation-involve-Death', 'Fasciculation-generalise-Death', 'Liver Cirrhosis-ameliorate-Fatty Liver', 'Diabetes Mellitus-improve-Albuminuria', 'Pulmonary Disease, Chronic Obstructive-improve-Albuminuria', 'Kidney Diseases-improve-Albuminuria', 'Heart Diseases-hospitalized-Heart Failure', 'Acute Kidney Injury-use-Kidney Diseases', 'Squamous Cell Carcinoma of Head and Neck-present-Death', 'Retinal Degeneration-distinguish-Alzheimer Disease', 'Death-occur-Liver Failure', 'Short Bowel Syndrome-develop-Liver Failure', 'Sepsis-develop-Liver Failure', 'Dyspnea-reported-Hemorrhage', 'Death-consider-Weight Loss', 'Bradycardia-caused-Seizures', 'Cockayne Syndrome-characterized-Cataract', 'Heart Arrest-lead-Syncope', 'Death-exclude-Ischemic Attack, Transient', 'Diabetic Foot-experience-Nervous System Diseases', 'Diabetic Foot-experience-Skin Diseases', 'Diabetic Foot-place-Infections', 'Nervous System Diseases-place-Infections', 'Skin Diseases-place-Infections', 'Brain Ischemia-associated-Heart Failure', 'Heart Failure-associated-Brain Ischemia', 'Postoperative Cognitive Complications-investigate-Delirium', 'Heart Diseases-accelerate-Obesity', 'Heart Diseases-accelerate-Diabetes Mellitus', 'Retinal Diseases-include-Diabetes Mellitus', 'Diabetes Mellitus-associated-Diabetic Nephropathies', 'Diabetic Nephropathies-associated-Diabetes Mellitus', 'Heart Diseases-develop-Dementia', 'Neoplasms-influence-Infections', 'Fragile X Syndrome-present-Arbovirus Infections', 'Thrombosis-lead-Blood Platelet Disorders', 'Kidney Neoplasms-develop-Sarcoma, Kaposi', 'Stroke-identify-Hypertension', 'Stroke-defined-Death', 'Kidney Failure, Chronic-mediate-Hypertension', 'Pain-depend-Mouth Diseases', 'Dementia-live-Stroke', 'Metabolic Syndrome-found-Obesity', 'Metabolic Syndrome-found-Cardiovascular Diseases', 'Neoplasms-include-Fractures, Spontaneous', 'Diabetes Mellitus-compare-Hepatic Encephalopathy', 'Genetic Diseases, Inborn-predispose-Atherosclerosis', 'Genetic Diseases, Inborn-predisposed-Cardiovascular Diseases', 'Neoplasms-suffer-Fasciculation', 'Neoplasms-suffer-Cachexia', 'Coma-associated-Brain Injuries, Traumatic', 'Brain Injuries, Traumatic-associated-Coma', 'Hematoma, Subdural, Acute-associated-Brain Injuries, Traumatic', 'Brain Injuries, Traumatic-associated-Hematoma, Subdural, Acute', 'Death-observed-Brain Injuries, Traumatic', 'Intracranial Aneurysm-associated-Ischemia', 'Ischemia-associated-Intracranial Aneurysm', 'Intracranial Aneurysm-associated-Aneurysm', 'Aneurysm-associated-Intracranial Aneurysm', 'Constipation-improve-Fecal Incontinence', 'Diarrhea-improve-Fecal Incontinence', 'Protein-Energy Malnutrition-covered-Fractures, Bone', 'Reflex, Abnormal-increase-Wounds and Injuries', 'Sarcopenia-appreciated-Metabolic Diseases', 'Hemorrhage-exclude-Renal Insufficiency', 'Bone Neoplasms-associated-Kyphosis', 'Kyphosis-associated-Bone Neoplasms', 'Stroke-present-Atrial Fibrillation', 'Heart Failure-play-Ischemia', 'Coronary Artery Disease-result-Myocardial Infarction', 'Heart Failure-result-Myocardial Infarction', 'Heart Failure-prevent-Death, Sudden, Cardiac', 'Death-rise-Cardiovascular Diseases', 'Heart Diseases-undergo-Heart Failure', 'Diabetes Mellitus-Establish-Alzheimer Disease', 'Communicable Diseases-associated-Muscular Diseases', 'Muscular Diseases-associated-Communicable Diseases', 'Pulmonary Disease, Chronic Obstructive-evaluate-Carcinoma, Non-Small-Cell Lung', 'Amyloidosis-manifest-Ventricular Fibrillation', 'Amyloidosis-manifest-Heart Failure', 'Heart Diseases-yield-Dyspnea', 'Leukoencephalopathies-mediated-Alzheimer Disease', 'Parkinson Disease-converted-Dementia', 'Parkinson Disease, Secondary-diagnose-Parkinson Disease', 'Obesity-linked-Cardiovascular Diseases', 'HIV Infections-lead-AIDS Arteritis, Central Nervous System', 'HIV Infections-disrupt-AIDS Arteritis, Central Nervous System', 'Weight Loss-prevent-Obesity', 'Neoplasms-use-Drug-Related Side Effects and Adverse Reactions', 'Chronic Disease-publish-Death', 'Microvascular Angina-evaluate-Cystic Fibrosis', 'Cystic Fibrosis-affected-Atherosclerosis', 'Atherosclerosis-affect-Cystic Fibrosis', 'Endometrial Neoplasms-tend-Obesity', 'Neoplasms-tend-Obesity', 'Lymphoma-transform-Ovarian Neoplasms', 'Endometrial Neoplasms-transform-Lymphoma', 'Death-cause-Skin Neoplasms', 'Skin Neoplasms-rise-Death', 'Infections-present-Cough', 'Skin Neoplasms-exclude-Neoplasms', 'Inflammation-improve-HIV Infections', 'Drug-Related Side Effects and Adverse Reactions-cause-Dry Eye Syndromes', 'Drug-Related Side Effects and Adverse Reactions-develop-Retinal Artery Occlusion', 'Dry Eye Syndromes-develop-Retinal Artery Occlusion', 'Muscular Diseases-associated-Non-alcoholic Fatty Liver Disease', 'Non-alcoholic Fatty Liver Disease-associated-Muscular Diseases', 'Sleep Apnea Syndromes-characterized-Airway Obstruction', 'Death-estimate-Tuberculosis', 'Tuberculosis-associated-Neoplasms', 'Neoplasms-associated-Tuberculosis', 'Tuberculosis-associated-Respiratory Tract Diseases', 'Respiratory Tract Diseases-associated-Tuberculosis', 'Ocular Motility Disorders-approved-Constipation', 'Hemorrhage-treat-Pulmonary Embolism', 'Ocular Motility Disorders-improve-Constipation', 'Alzheimer Disease-present-Dementia, Vascular', 'Metabolic Syndrome-associated-Alcoholism', 'Alcoholism-associated-Metabolic Syndrome', 'Metabolic Syndrome-increase-Diabetes Mellitus', 'Sarcopenia-drawe-Neoplasms', 'Sarcopenia-contribute-Stomach Neoplasms', 'Nervous System Diseases-reach-Death', 'Thrombosis-reach-Death', 'Neurodegenerative Diseases-considered-Dementia', 'Alzheimer Disease-induce-Inflammation', 'Sarcopenia-induce-Hyponatremia', 'Mitochondrial Diseases-lead-Sarcopenia', 'Aphasia-describe-Stroke', 'Aniseikonia-increase-Cataract', 'Anisometropia-increase-Cataract', 'Cataract-eliminate-Vision Disorders', 'Pancreatitis, Chronic-lead-Pain', 'Pancreatic Neoplasms-lead-Pain', 'Stroke-association-Alzheimer Disease', 'Alzheimer Disease-association-Dementia', 'Hypotension-shown-Fractures, Bone', 'Hypotension-shown-Death', 'Amyloidosis-ascribed-Diabetes Mellitus', 'Amyloidosis-distribute-Diabetes Mellitus', 'Neoplasms-underlie-Death', 'Leukoencephalopathies-represent-Dementia', 'Diabetes Mellitus-given-Kidney Diseases', 'Hypertension-given-Kidney Diseases', 'Heart Failure-depend-Death, Sudden, Cardiac', 'Chemical and Drug Induced Liver Injury-associated-Drug Overdose', 'Drug Overdose-associated-Chemical and Drug Induced Liver Injury', 'Liver Failure-associated-Drug Overdose', 'Drug Overdose-associated-Liver Failure', 'Dysphonia-present-Fatigue', 'Back Pain-observed-Hand Injuries', 'Neck Pain-observed-Hand Injuries', 'Gastroenteritis-report-Death', 'Infections-produce-Death', 'Clostridium Infections-produce-Death', 'Death-include-Respiratory Tract Diseases', 'Death-underlie-Respiratory Tract Diseases', 'Cross Infection-produce-Death', 'Death-include-Pneumonia, Aspiration', 'Dyspnea-report-Pulmonary Disease, Chronic Obstructive', 'Learning Disabilities-viewed-Alzheimer Disease', 'Hypertension-include-Mastocytosis, Systemic', 'Autoimmune Diseases-include-Mastocytosis, Systemic', 'Thromboembolism-prevent-Atrial Fibrillation', 'Pain-caused-Musculoskeletal Diseases', 'Chronic Pain-produced-Spinal Diseases', 'Diabetes Mellitus-assessed-Acute Coronary Syndrome', 'Diabetes Mellitus-receive-Acute Coronary Syndrome', 'Atrial Fibrillation-associated-Cardiac Output, Low', 'Cardiac Output, Low-associated-Atrial Fibrillation', 'Cardiac Output, Low-associated-Cerebral Infarction', 'Cerebral Infarction-associated-Cardiac Output, Low', 'Cardiac Output, Low-fall-Diurnal Enuresis', 'Renal Insufficiency, Chronic-describe-Cardiovascular Diseases', 'Cardiovascular Diseases-increase-Renal Insufficiency, Chronic', 'Diabetes Mellitus-increase-Renal Insufficiency, Chronic', 'Vision Disorders-examine-Hip Fractures', 'Vision Disorders-examine-Dementia', 'Vision, Low-associated-Hip Fractures', 'Hip Fractures-associated-Vision, Low', 'Vision, Low-associated-Dementia', 'Dementia-associated-Vision, Low', 'Alzheimer Disease-manifest-Metabolic Diseases', 'Fractures, Bone-associated-Bone Neoplasms', 'Bone Neoplasms-associated-Fractures, Bone', 'Death-linked-Infections', 'Death-linked-Neoplasms', 'Death-linked-Brain Diseases', 'Death-linked-Pneumonia', 'Death-linked-Wasting Syndrome', 'Paresis-show-Reflex, Abnormal', 'Blindness-coupled-Anophthalmos', 'Blindness-cause-Multiple Chronic Conditions', 'Infections-caused-Bone Marrow Diseases', 'Headache Disorders, Secondary-become-Psychomotor Agitation', 'Headache Disorders, Secondary-internalize-Psychomotor Agitation', 'Immunologic Deficiency Syndromes-associated-Atherosclerosis', 'Atherosclerosis-associated-Immunologic Deficiency Syndromes', 'Immunologic Deficiency Syndromes-accompany-Atherosclerosis', 'Keratoconjunctivitis-occur-Drug Hypersensitivity', 'Keratoconjunctivitis-occur-Respiratory Insufficiency', 'Drug Hypersensitivity-occur-Respiratory Insufficiency', 'Keratoconjunctivitis-aimed-Vision Disorders', 'Keratoconjunctivitis-reduce-Vision Disorders', 'Stroke-excluded-Ischemia', 'Neoplasms-ascertained-Sarcoma', 'Death-related-Leukemia, Myelogenous, Chronic, BCR-ABL Positive', 'Inflammation-cause-Nerve Degeneration', 'Sarcopenia-associate-Malnutrition', 'Malnutrition-associate-Sarcopenia', 'Vascular Calcification-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-Vascular Calcification', 'Renal Insufficiency, Chronic-related-Vascular Calcification', 'Kidney Diseases-recommended-Renal Insufficiency, Chronic', 'Malnutrition-inhibit-Renal Insufficiency, Chronic', 'Vascular Calcification-inhibit-Renal Insufficiency, Chronic', 'Vascular Calcification-prevent-Renal Insufficiency, Chronic', 'Diabetes Mellitus-determine-Death', 'Hypoalbuminemia-determine-Death', 'Cleft Lip-treat-Adrenal Insufficiency', 'Heart Failure-considered-Shy-Drager Syndrome', 'Heart Failure-considered-Respiratory Insufficiency', 'Respiratory Insufficiency-include-Shy-Drager Syndrome', 'Neurologic Manifestations-appear-Parkinson Disease', 'Raynaud Disease-produce-Ischemia', 'Ischemia-produce-Fever', 'Sleep Initiation and Maintenance Disorders-open-Vision Disorders', 'Fractures, Bone-precede-Pain', 'Wounds and Injuries-precede-Pain', 'Pain-precede-Neoplasms', 'Brain Damage, Chronic-induced-Cerebral Hemorrhage', 'Inflammation-contribute-Chronic Disease', 'Dermatitis-characterized-Inflammation', 'Dermatitis-divided-Dermatitis, Contact', 'Inflammation-characterized-Dermatitis, Contact', 'Dermatitis-occur-Skin Diseases', 'Neoplasms-prevent-Carcinogenesis', 'Nervous System Diseases-include-Genetic Diseases, Inborn', 'Carcinogenesis-induced-Adenocarcinoma', 'Myelodysplastic Syndromes-represent-Neoplasms', 'Myelodysplastic Syndromes-demonstrate-Hematologic Diseases', 'Hyperglycemia-relate-Diabetes Mellitus, Type 2', 'Myelodysplastic Syndromes-evolve-Leukemia, Myeloid, Acute', 'Hyperglycemia-aggravate-Sarcopenia', 'Neoplasms-demonstrate-Hematologic Diseases', 'Diabetes Mellitus, Type 2-aggravate-Sarcopenia', 'Neoplasms-evolve-Leukemia, Myeloid, Acute', 'Hematologic Diseases-evolve-Leukemia, Myeloid, Acute', 'Diabetic Nephropathies-associated-Sarcopenia', 'Sarcopenia-associated-Diabetic Nephropathies', 'Diabetic Nephropathies-associated-Diabetes Mellitus, Type 2', 'Diabetes Mellitus, Type 2-associated-Diabetic Nephropathies', 'Dementia-live-Parkinson Disease', 'Dementia-live-Musculoskeletal Diseases', 'Dementia-live-Nervous System Diseases', 'Parkinson Disease-live-Musculoskeletal Diseases', 'Parkinson Disease-live-Nervous System Diseases', 'Musculoskeletal Diseases-live-Nervous System Diseases', 'Esophageal Achalasia-carry-Gastroesophageal Reflux', 'Wounds and Injuries-undergo-Death', 'Cerebral Infarction-expose-Death', 'Death-challenged-Infections', 'Hypertension-linked-Leukoaraiosis', 'Uterine Retroversion-originate-Glomerulosclerosis, Focal Segmental', 'Leukoaraiosis-emerge-Cardiomyopathy, Hypertrophic', 'Glomerulosclerosis, Focal Segmental-form-Uterine Retroversion', 'Adenocarcinoma, Mucinous-defined-Neoplasms', 'Alzheimer Disease-test-Dementia', "Xerostomia-associated-Sjogren's Syndrome", "Sjogren's Syndrome-associated-Xerostomia", 'Somnambulism-show-Venous Thromboembolism', 'Obesity-confer-Alzheimer Disease', 'Obesity-confer-Atrophy', 'Colitis, Ulcerative-make-Immune System Diseases', 'Chronic Disease-associated-Sexual Dysfunction, Physiological', 'Sexual Dysfunction, Physiological-associated-Chronic Disease', 'Inflammation-associated-Lymphoma, B-Cell', 'Lymphoma, B-Cell-associated-Inflammation', 'Chronic Pain-detected-Sensation Disorders', 'Arm Injuries-composed-Alzheimer Disease', 'Lung Neoplasms-cause-Death', 'Pulmonary Disease, Chronic Obstructive-cause-Death', 'Hepatitis B-account-Carcinoma, Hepatocellular', 'Hepatitis B-account-Death', 'DiGeorge Syndrome-characterized-Lymphoma, T-Cell', 'Immunologic Deficiency Syndromes-characterized-Lymphoma, T-Cell', 'DiGeorge Syndrome-predispose-Infections', 'DiGeorge Syndrome-predispose-Drug Hypersensitivity', 'Cleft Palate-represent-Otitis', 'Cleft Palate-represent-Pleural Effusion', 'Infections-represent-Abnormalities, Drug-Induced', 'Progeria-submitted-Coronary Artery Disease', 'Infections-represent-Immunologic Deficiency Syndromes', 'Myocardial Infarction-submitted-Coronary Artery Disease', 'Genetic Diseases, Inborn-characterized-Myocardial Infarction', 'Genetic Diseases, Inborn-characterized-Stroke', 'Drug Hypersensitivity-associated-Lymphopenia', 'Lymphopenia-associated-Drug Hypersensitivity', 'Musculoskeletal Diseases-associated-Fatigue', 'Fatigue-associated-Musculoskeletal Diseases', 'Hantavirus Pulmonary Syndrome-known-Fractures, Bone', 'Stroke-induce-Metabolic Diseases', 'Stroke-induce-Muscular Atrophy', 'Stroke-lead-Sarcopenia', 'Metabolic Diseases-lead-Sarcopenia', 'Muscular Atrophy-lead-Sarcopenia', 'Hepatitis B-include-Chemical and Drug Induced Liver Injury', 'Alcoholism-include-Chemical and Drug Induced Liver Injury', 'Hepatitis B-lead-Fatty Liver', 'Alcoholism-lead-Fatty Liver', 'Chemical and Drug Induced Liver Injury-lead-Fatty Liver', 'Pain-associated-Atrophy', 'Atrophy-associated-Pain', 'Hearing Loss-perpetuate-Neurodegenerative Diseases', 'Hearing Loss-perpetuate-Dementia', 'Anemia, Sickle Cell-become-Chronic Disease', 'Dyspnea-linked-Anemia', 'Anemia, Sickle Cell-linked-Anemia', 'Hiccup-predispose-Diabetes Mellitus', 'Acute Coronary Syndrome-predispose-Diabetes Mellitus', 'Hypertension, Pulmonary-linked-Heart Failure', 'Cardiomyopathies-associated-Anemia, Sickle Cell', 'Anemia, Sickle Cell-associated-Cardiomyopathies', 'Cardiomyopathies-emerging-Death', 'Ischemia-represent-Atherosclerosis', 'Ischemia-manifested-Pain', 'Atherosclerosis-manifested-Pain', 'Fibrosis-reduce-Inflammation', 'Cardiovascular Diseases-interact-Multiple Sclerosis', 'Glucose Intolerance-predispose-Diabetes Mellitus', 'Sarcopenia-associate-Diabetes Mellitus', 'Diabetes Mellitus-associate-Sarcopenia', 'Cartilage Diseases-prevent-Osteoarthritis', 'Diabetes Mellitus-screen-Headache Disorders, Secondary', 'Multiple Sclerosis-present-Neurodegenerative Diseases', 'Sleep Wake Disorders-associated-Delirium', 'Delirium-associated-Sleep Wake Disorders', 'Pneumocephalus-associated-Delirium', 'Delirium-associated-Pneumocephalus', 'Fibrosis-protect-Heart Diseases', 'Death-associated-Cellulitis', 'Cellulitis-associated-Death', 'Lymphedema-defined-Neoplasms', 'Lymphedema-defined-Wounds and Injuries', 'Lymphedema-defined-Filariasis', 'Lung Diseases-account-Death', 'Sleep Apnea Syndromes-relate-Atherosclerosis', 'Death-related-Shock, Septic', 'Death-related-Blood Coagulation Disorders', 'Genetic Diseases, Inborn-include-Hearing Disorders', 'Diabetes Mellitus-construct-Arteriovenous Fistula', 'Peripheral Vascular Diseases-construct-Arteriovenous Fistula', 'Bone Neoplasms-predispose-Fractures, Bone', 'Oculocerebrorenal Syndrome-predispose-Fractures, Bone', 'Renal Insufficiency, Chronic-accompanied-Inflammation', 'Fatty Liver-associated-Liver Cirrhosis', 'Liver Cirrhosis-associated-Fatty Liver', 'Alzheimer Disease-faced-Adrenoleukodystrophy', 'Neurodegenerative Diseases-bypass-Parkinson Disease', 'Death-quantify-Dementia', 'Chronic Disease-include-Frailty', 'Fractures, Bone-coupled-Osteoporosis', 'Coronary Artery Disease-resemble-Hypertension', 'Metabolic Syndrome-measure-Obesity', 'Metabolic Syndrome-consider-Cytomegalovirus Infections', 'Metabolic Syndrome-show-Weight Loss', 'Neoplasms-rise-Death', 'Neoplasms-expand-Death', 'Discitis-mimic-Tuberculosis, Spinal', 'Drug-Related Side Effects and Adverse Reactions-understand-Synucleinopathies', 'Drug-Related Side Effects and Adverse Reactions-understand-Neurodegenerative Diseases', 'Neurodegenerative Diseases-treat-Low Back Pain', 'Neurodegenerative Diseases-treat-Musculoskeletal Diseases', 'Low Back Pain-treat-Musculoskeletal Diseases', 'Wounds and Injuries-cause-Nervous System Diseases', 'Wounds and Injuries-degenerate-Back Pain', 'Back Pain-include-Nervous System Diseases', 'Sarcopenia-include-Malnutrition', 'Hyperglycemia-include-Metabolic Syndrome', 'Fibrosis-include-End Stage Liver Disease', 'Death-compared-Osteoporosis', 'Alzheimer Disease-delay-Ependymoma', 'Signs and Symptoms, Digestive-raise-Hyponatremia', 'Consciousness Disorders-raise-Hyponatremia', 'Parkinson Disease-known-Neurodegenerative Diseases', 'Edema-raise-Hyponatremia', 'Hearing Loss-raise-Hyponatremia', 'Inflammation-reduce-Osteoarthritis', 'Immunologic Deficiency Syndromes-exert-Inflammation', 'Hyponatremia-raise-Thrombocytopenia', 'Dementia-make-Diabetes Mellitus', 'Vision Disorders-make-Diabetes Mellitus', 'Inflammation-regulate-Osteoarthritis', 'Inflammation-predispose-Neurodegenerative Diseases', 'Inflammation-promote-Cardiovascular Diseases', 'Death-include-Renal Insufficiency, Chronic', 'Pain-considered-Psoas Abscess', 'Hip Fractures-stratified-Hypertension', 'Glaucoma-cause-Vision Disorders', 'Neurodegenerative Diseases-cause-Blindness', 'Vision Disorders-cause-Blindness', 'Dementia-receive-Cataract', 'Cataract-receive-Dementia', 'Fibrosis-result-Multiple Organ Failure', 'Edema-favor-Varicose Ulcer', 'Arthritis, Rheumatoid-develop-Cardiovascular Diseases', 'Arthritis, Rheumatoid-prevent-Musculoskeletal Diseases', 'Brain Injuries, Traumatic-associated-Consciousness Disorders', 'Consciousness Disorders-associated-Brain Injuries, Traumatic', 'Brain Injuries, Traumatic-associated-Neurologic Manifestations', 'Neurologic Manifestations-associated-Brain Injuries, Traumatic', 'Hypercalcemia-show-Parathyroid Neoplasms', 'Neoplasms-include-Mucositis', 'Blindness-prevent-Vision Disorders', 'Neoplasms-accompanied-Phlebitis', 'Neoplasms-accompanied-Fibrosis', 'Communication Disorders-arise-Hearing Loss', 'Communication Disorders-arise-Voice Disorders', 'Communication Disorders-arise-Head and Neck Neoplasms', 'Communication Disorders-arise-Heredodegenerative Disorders, Nervous System', 'Urinary Incontinence-emerge-Hypertension', 'Neoplasms-emerge-Hypertension', 'Dementia-emerge-Hypertension', 'Arthritis, Rheumatoid-considered-Hypertension', 'Arthritis, Rheumatoid-considered-Cardiovascular Diseases', 'Pneumonia-lack-Pneumococcal Infections', 'Rhabdomyosarcoma-differentiated-Neoplasms', 'Diabetes Mellitus, Type 2-tempered-Osteoporosis', 'Diarrhea-result-Death', 'Colitis-result-Death', 'Hemorrhage-caused-Neoplasms', 'Airway Obstruction-caused-Neoplasms', 'Metabolic Syndrome-obtained-Renal Insufficiency, Chronic', 'Dry Eye Syndromes-lubricate-Inflammation', 'Heart Arrest-exist-Atrial Fibrillation', 'Hypoxia-ameliorate-Muscle Weakness', 'Acute Kidney Injury-complicate-Pyelonephritis', 'Death-remain-Communicable Diseases', 'Acute Kidney Injury-associated-Pyelonephritis', 'Pyelonephritis-associated-Acute Kidney Injury', 'Thoracic Injuries-represent-Wounds and Injuries', 'Death-observed-Stroke', 'Death-observed-Hemorrhage', 'Stroke-observed-Hemorrhage', 'Myelodysplastic Syndromes-include-Leukemia, Myeloid', 'Leukemia, Myeloid, Acute-include-Leukemia, Myeloid', 'Tendinopathy-hypothesize-Hypoxia', 'Hypoxia-occur-Tendinopathy', 'Cardiovascular Diseases-associated-Hypertrophy', 'Hypertrophy-associated-Cardiovascular Diseases', 'Brain Injuries-linked-Substance-Related Disorders', 'Brain Injuries-linked-Stroke', 'Calcinosis-cause-Ventricular Outflow Obstruction', 'Cachexia-defined-Anorexia', 'Waldenstrom Macroglobulinemia-followed-Lymphohistiocytosis, Hemophagocytic', 'Diabetes Mellitus-include-Alzheimer Disease', 'Stroke-include-Alzheimer Disease', 'Diabetes Mellitus-involved-Alzheimer Disease', 'Fatigue-associated-Hypotension', 'Hypotension-associated-Fatigue', 'Inflammation-involved-Multiple Sclerosis', 'Inflammation-involved-Neurodegenerative Diseases', 'Inflammation-involved-Alzheimer Disease', 'Encephalitis-accelerate-Nervous System Diseases', 'Inflammation-involved-Parkinson Disease', 'Meningitis-include-Infections', 'Parkinson Disease-reduce-Brain Diseases', 'Death-diagnose-Short Bowel Syndrome', 'Death-diagnose-Hernia, Abdominal', 'Scoliosis-considered-Neuroma, Acoustic', 'Death-request-Neurodegenerative Diseases', 'Death-request-Lung Diseases', 'Weight Loss-request-Neurodegenerative Diseases', 'Weight Loss-request-Lung Diseases', 'Heart Failure-present-Death', 'Mastocytosis, Systemic-present-Death', 'Dysbiosis-linked-Metabolic Syndrome', 'Alzheimer Disease-drive-Headache Disorders, Secondary', 'Alzheimer Disease-predispose-Postoperative Cognitive Complications', 'Nervous System Diseases-result-Communicable Diseases', 'Atrophy-compare-Alzheimer Disease', 'Lymphatic Diseases-included-Venous Thrombosis', 'Dementia-linked-Hypertension', 'Hypertension-linked-Alzheimer Disease', 'Liver Failure-address-Chemical and Drug Induced Liver Injury', 'Death-address-Chemical and Drug Induced Liver Injury', 'Hypertension-underlie-Alzheimer Disease', 'Dementia-underlie-Alzheimer Disease', 'Hypertension-promote-Alzheimer Disease', 'Hypertension-show-Death', 'Death-related-Bacteremia', 'Bacteremia-occur-Pneumonia', 'Dementia-culminate-Death', 'Dementia-experience-Weight Loss', 'Dementia-experience-Malnutrition', 'Dementia-lead-Dehydration', 'Alzheimer Disease-trigger-Inflammation', 'Inflammation-linked-Polycystic Ovary Syndrome', 'Arteriovenous Fistula-preclude-Venous Thrombosis', 'Metabolic Syndrome-associated-Thyroid Nodule', 'Thyroid Nodule-associated-Metabolic Syndrome', 'Fractures, Bone-stratify-Wounds and Injuries', 'Cardiovascular Diseases-spent-Heart Failure', 'Seizures-begin-Epilepsy', 'Hyponatremia-associated-Stroke', 'Stroke-associated-Hyponatremia', 'Hyponatremia-associated-Alzheimer Disease', 'Alzheimer Disease-associated-Hyponatremia', 'Seizures-concerned-Epilepsy', 'Hypertension-improve-Chronic Disease', 'Diabetes Mellitus-improve-Chronic Disease', 'Seizures-delayed-Stroke', 'Seizures-define-Epilepsy', 'Stroke-define-Epilepsy', 'Hearing Loss, Central-hear-Retinal Degeneration', 'Renal Insufficiency-associated-Delirium', 'Delirium-associated-Renal Insufficiency', 'Heredodegenerative Disorders, Nervous System-associated-Delirium', 'Delirium-associated-Heredodegenerative Disorders, Nervous System', 'Parkinson Disease-characterized-Muscle Hypertonia', 'Neurodegenerative Diseases-characterized-Muscle Hypertonia', 'Inflammation-involved-Ovarian Neoplasms', 'Olfaction Disorders-mediated-Inflammation', 'Death-mediated-Inflammation', 'Endocrine System Diseases-Results-Sarcopenia', 'Endocrine System Diseases-share-Sarcopenia', 'Sarcopenia-vary-Endocrine System Diseases', 'Death-validate-Hip Fractures', 'Muscular Disorders, Atrophic-distinguished-Fractures, Bone', 'Urinary Bladder, Neurogenic-provide-Memory Disorders', 'Urinary Bladder, Neurogenic-underlie-Memory Disorders', 'Urinary Bladder, Neurogenic-provide-Alzheimer Disease', 'Urinary Bladder, Neurogenic-underlie-Alzheimer Disease', 'Vision Disorders-exhibit-Atherosclerosis', 'Death-related-Respiratory Insufficiency', 'Dementia-modeled-Death', 'Dementia-compete-Death', 'Obesity-used-Weight Loss', 'Cardiovascular Diseases-invite-Diabetes Mellitus', 'Cardiovascular Diseases-work-Diabetes Mellitus', 'Lung Diseases-identify-Pneumonia, Pneumocystis', 'Lung Diseases-identify-Death', 'Pneumonia, Pneumocystis-identify-Death', 'Autoimmune Diseases-known-Pneumonia, Pneumocystis', 'Lung Diseases-known-Pneumonia, Pneumocystis', 'Atrial Fibrillation-associate-Dementia', 'Dementia-associate-Atrial Fibrillation', 'Neurodegenerative Diseases-related-Atrial Fibrillation', 'Fractures, Bone-fall-Cardiovascular Diseases', 'Fractures, Bone-fall-Death', 'Cardiovascular Diseases-fall-Death', 'Diabetes Mellitus-suffer-Brain Injuries, Traumatic', 'Cerebral Infarction-suffer-Brain Injuries, Traumatic', 'Nephrotic Syndrome-suffer-Brain Injuries, Traumatic', 'Endometrial Neoplasms-suffer-Brain Injuries, Traumatic', 'Brain Ischemia-suffer-Brain Injuries, Traumatic', 'Leukemia-suffer-Brain Injuries, Traumatic', 'Urinary Bladder Neoplasms-suffer-Brain Injuries, Traumatic', 'Pulmonary Disease, Chronic Obstructive-suffer-Brain Injuries, Traumatic', 'Obesity-alleviate-Lipoma', 'Hemolytic-Uremic Syndrome-lead-Cytomegalovirus Infections', 'Hemolytic-Uremic Syndrome-lead-Kidney Failure, Chronic', 'Renal Insufficiency-lead-Cytomegalovirus Infections', 'Renal Insufficiency-study-Kidney Failure, Chronic', 'Cytomegalovirus Infections-study-Kidney Failure, Chronic', 'Ulcer-receive-Osteoporosis', 'Gangrene-know-Cross Infection', 'Gangrene-know-Fever', 'Machado-Joseph Disease-reduce-Death', 'Heart Failure-develop-Cardiovascular Diseases', 'Amyloidosis-associated-Inflammation', 'Inflammation-associated-Amyloidosis', 'Progeria-caused-Atherosclerosis', 'Death-lead-Atherosclerosis', 'Vision Disorders-include-Progeria', 'Atherosclerosis-include-Progeria', 'Progeria-demonstrate-Vision Disorders', 'Progeria-demonstrate-Atherosclerosis', 'Progeria-created-Atherosclerosis', 'Sarcopenia-demonstrate-Muscular Dystrophy, Duchenne', 'Hypertension-lead-Hypotension', 'Hyperhomocysteinemia-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-Hyperhomocysteinemia', 'Wilms Tumor-followed-Adenocarcinoma', 'Neuroblastoma-followed-Adenocarcinoma', 'Neoplasms-followed-Adenocarcinoma', 'Infections-focus-Tuberculosis', 'Infections-treat-Tuberculosis', 'Wounds and Injuries-induced-Tinnitus', 'Hearing Disorders-suggested-Tinnitus', 'Progeria-ameliorate-Drug-Related Side Effects and Adverse Reactions', 'Inflammation-prevent-Cardiovascular Diseases', 'Mitochondrial Diseases-play-Alzheimer Disease', 'Mitochondrial Diseases-play-Parkinson Disease', 'Mitochondrial Diseases-play-Huntington Disease', 'Fallopian Tube Diseases-lead-Infertility, Female', 'Chlamydia Infections-lead-Infertility, Female', 'Death-come-Pupil Disorders', 'Kidney Diseases-limit-Stroke', 'Cardiovascular Diseases-caused-Vascular System Injuries', 'Salmonella Infections-require-Infections', 'Muscular Dystrophy, Duchenne-contribute-Muscular Diseases', 'Diabetes Mellitus-associated-Overbite', 'Overbite-associated-Diabetes Mellitus', 'Prostatic Neoplasms-suffer-Cardiovascular Diseases', 'Cerebrovascular Disorders-include-Heart Diseases', 'Metabolic Diseases-result-Atherosclerosis', 'Dyslipidemias-result-Atherosclerosis', 'Hypertension-associated-Angina Pectoris', 'Angina Pectoris-associated-Hypertension', 'Diabetes Mellitus-associated-Angina Pectoris', 'Angina Pectoris-associated-Diabetes Mellitus', 'Erectile Dysfunction-evaluate-Sexual Dysfunction, Physiological', 'Neoplasms-explain-Death', 'Fibrosis-explain-Death', 'Death-compare-Hip Fractures', 'Peripheral Arterial Disease-follow-Hypertension', 'Peripheral Arterial Disease-follow-Diabetes Mellitus', 'HIV Infections-continue-AIDS Arteritis, Central Nervous System', 'AIDS Arteritis, Central Nervous System-occur-Central Nervous System Diseases', 'HIV Infections-consider-AIDS Arteritis, Central Nervous System', 'Cerebrovascular Disorders-prevent-Stroke', 'Respiratory Insufficiency-caused-Airway Obstruction', 'Inflammation-alter-Hepatitis, Viral, Human', 'Sarcopenia-exhibit-Osteoporosis', 'Wounds and Injuries-followed-Respiratory Tract Diseases', 'Wounds and Injuries-followed-Cardiovascular Diseases', 'Sleep Wake Disorders-combined-Fatigue', 'Amyotrophic Lateral Sclerosis-promote-Sleep Initiation and Maintenance Disorders', 'Myalgia-caused-Genetic Diseases, Inborn', 'Death-include-Shock, Hemorrhagic', 'Skin Ulcer-followed-Dementia', 'Death-contribute-Wounds and Injuries', 'Death-include-Delirium', 'Pelvic Floor Disorders-include-Urinary Incontinence', 'Dementia-assessed-Sleep Wake Disorders', 'Sleep Wake Disorders-base-Dementia', 'Sleep Wake Disorders-assessed-Sleep Apnea Syndromes', 'Death-caused-Pulmonary Disease, Chronic Obstructive', 'Death-adjusted-Pulmonary Disease, Chronic Obstructive', 'Pulmonary Disease, Chronic Obstructive-adjusted-Pneumonia', 'Pulmonary Disease, Chronic Obstructive-adjusted-Respiratory Tract Diseases', 'Critical Illness-develop-Delirium', 'Seizures-predict-Alzheimer Disease', 'Seizures-account-Alzheimer Disease', 'Myocardial Infarction-suffer-Acute Coronary Syndrome', 'Myocardial Infarction-suffer-Chest Pain', 'Atrophy-characterize-Alzheimer Disease', 'Hepatomegaly-characterize-Alzheimer Disease', 'Thrombophilia-associated-Venous Thrombosis', 'Venous Thrombosis-associated-Thrombophilia', 'Hepatitis C-associated-Venous Thrombosis', 'Venous Thrombosis-associated-Hepatitis C', 'Sexual Dysfunction, Physiological-seek-Erectile Dysfunction', 'Renal Insufficiency-associated-Venous Thrombosis', 'Venous Thrombosis-associated-Renal Insufficiency', 'Obesity-associated-Venous Thrombosis', 'Venous Thrombosis-associated-Obesity', 'Diabetes Mellitus-associated-Venous Thrombosis', 'Venous Thrombosis-associated-Diabetes Mellitus', 'Oculocerebrorenal Syndrome-prevent-Arthritis, Rheumatoid', 'Heart Failure-develop-Anemia', 'Sepsis-rank-Death', 'Osteoarthritis-include-Musculoskeletal Diseases', 'Osteoporosis-include-Musculoskeletal Diseases', 'Sarcopenia-include-Musculoskeletal Diseases', 'Hip Fractures-assessed-Death', 'Hip Fractures-assessed-Pain', 'Nervous System Diseases-confoun-Brain Injuries, Traumatic', 'Nervous System Diseases-associated-Craniocerebral Trauma', 'Craniocerebral Trauma-associated-Nervous System Diseases', 'Delayed Emergence from Anesthesia-restore-Heart Failure', 'Heart Diseases-restore-Heart Failure', 'Brain Diseases-experience-Hearing Loss', 'Aortic Aneurysm-result-Rupture', 'Heart Arrest-require-Hypothermia', 'Vision, Low-hear-Sensation Disorders', 'Obesity-compare-Chronic Disease', 'Neoplasms-driven-Obesity', 'Drug-Related Side Effects and Adverse Reactions-afford-Glioma', 'Weight Loss-hinder-Obesity', 'Liver Cirrhosis-suffer-Hepatic Encephalopathy', 'Chronic Disease-associated-Neurodegenerative Diseases', 'Neurodegenerative Diseases-associated-Chronic Disease', 'Movement Disorders-present-Parkinson Disease, Secondary', 'Parkinson Disease, Secondary-represent-Neurodegenerative Diseases', 'Mandibular Nerve Injuries-decrease-Hypoparathyroidism', 'Urinary Bladder Neoplasms-reported-Neoplasms', 'Obesity-influence-Neoplasms', 'Inflammation-derived-Urinary Bladder Neoplasms', 'HIV Infections-accelerate-Atherosclerosis', 'Coronary Artery Disease-contribute-Inflammation', 'Coronary Artery Disease-implicated-HIV Infections', 'Inflammation-mirror-Rupture', 'Hyperlipidemias-mirror-Rupture', 'HIV Infections-mirror-Rupture', 'HIV Infections-vary-Coronary Artery Disease', 'HIV Infections-reduce-Cardiovascular Diseases', 'Coronary Artery Disease-reduce-Cardiovascular Diseases', 'Stroke-live-HIV Infections', 'Viremia-increase-Stroke', 'HIV Infections-increase-Stroke', 'Viremia-increase-HIV Infections', 'HIV Infections-acquire-Stroke', 'Atrial Fibrillation-constitute-Arrhythmias, Cardiac', 'Cardiovascular Diseases-increase-Hypertension', 'Cardiovascular Diseases-related-Inflammation', 'Cardiovascular Diseases-increase-Inflammation', 'Atrial Fibrillation-correlated-Stroke', 'Sleep Initiation and Maintenance Disorders-affect-Neurodegenerative Diseases', 'Sleep Wake Disorders-affect-Neurodegenerative Diseases', 'Stroke-associated-Myocardial Infarction', 'Myocardial Infarction-associated-Stroke', 'Fractures, Bone-suffer-Accidental Injuries', 'Wounds and Injuries-remain-Obesity', 'Wounds and Injuries-increase-Death', 'Temporomandibular Joint Disorders-develop-Pain', 'Temporomandibular Joint Dysfunction Syndrome-produce-Pain', 'Neurodegenerative Diseases-produce-Pain', 'HIV Infections-present-Inflammation', 'Microtrauma, Physical-increase-Synovial Cyst', 'Fatigue-seen-Parkinson Disease', 'Fatigue-related-Parkinson Disease', 'Atrophy-related-Fatigue', 'Parkinson Disease-related-Fatigue', 'Hyperhomocysteinemia-cause-Cardiovascular Diseases', 'Hyperhomocysteinemia-cause-Osteoporotic Fractures', 'Hyperhomocysteinemia-cause-Dementia', 'Coinfection-infect-Infections', 'Aspergillosis-infect-Infections', 'Cardiac Output, Low-fall-Fatigue', 'Hip Fractures-used-Death', 'Craniocerebral Trauma-reveal-Death', 'Craniocerebral Trauma-increase-Death', 'Diabetes Mellitus-increase-Kidney Diseases', 'Diabetes Mellitus-increase-Nervous System Diseases', 'Diabetes Mellitus-increase-Retinal Diseases', 'Obesity-assigned-Weight Loss', 'Hearing Loss-follow-Deglutition Disorders', 'Hearing Loss-follow-Speech Disorders', 'Seizures-assessed-Epilepsy', 'Muscle Weakness-manage-Dental Caries', 'Death-achieve-Dementia', 'Neoplasms-created-Death', 'Neurodegenerative Diseases-related-Death', 'Neoplasms-explored-Diabetes Mellitus', 'Neoplasms-explored-Cardiovascular Diseases', 'Osteoporotic Fractures-predict-Osteoporosis', 'Cerebral Infarction-identify-Death', 'Aortic Valve Stenosis-regarded-Death, Sudden, Cardiac', 'Aortic Valve Stenosis-determine-Death, Sudden, Cardiac', 'Mitochondrial Diseases-contribute-Huntington Disease', 'Mitochondrial Diseases-contribute-Heredodegenerative Disorders, Nervous System', 'Sarcopenia-predispose-Fractures, Bone', 'Chronic Disease-occur-Bone Neoplasms', 'Chronic Disease-occur-Muscular Atrophy', 'Chronic Disease-lead-Osteoporosis', 'Chronic Disease-lead-Sarcopenia', 'Bone Neoplasms-lead-Osteoporosis', 'Osteoporosis-underpower-Hip Fractures', 'Alcoholism-differ-HIV Infections', 'Dehydration-associate-Death', 'Death-associate-Dehydration', 'Non-alcoholic Fatty Liver Disease-considered-Diabetes Mellitus, Type 2', 'Non-alcoholic Fatty Liver Disease-considered-Diabetes Mellitus', 'Non-alcoholic Fatty Liver Disease-confirm-Diabetes Mellitus', 'Diabetes Mellitus-include-Non-alcoholic Fatty Liver Disease', 'Diabetes Mellitus-tend-Non-alcoholic Fatty Liver Disease', 'Fibrosis-tend-Diabetes Mellitus', 'Fibrosis-include-Non-alcoholic Fatty Liver Disease', 'Non-alcoholic Fatty Liver Disease-summarize-Diabetes Mellitus', 'Non-alcoholic Fatty Liver Disease-detect-Fatty Liver', 'Non-alcoholic Fatty Liver Disease-review-Fibrosis', 'Diabetes Mellitus-detect-Fatty Liver', 'Diabetes Mellitus-review-Fibrosis', 'Colorectal Neoplasms-came-Neoplasms', 'Pain-associated-Arthralgia', 'Arthralgia-associated-Pain', 'Colorectal Neoplasms-experience-Hemorrhage', 'Long QT Syndrome-associated-Neoplasms', 'Neoplasms-associated-Long QT Syndrome', 'Long QT Syndrome-lead-Arrhythmias, Cardiac', 'Drug-Related Side Effects and Adverse Reactions-lead-Arrhythmias, Cardiac', 'Neoplasms-lead-Arrhythmias, Cardiac', 'Hypotension-cause-Nerve Degeneration', 'Hypotension-cause-Cerebral Infarction', 'Hypotension-cause-Dementia, Vascular', 'Leukoencephalopathies-produced-Cerebral Infarction', 'Nerve Degeneration-feature-Cerebral Infarction', 'Nerve Degeneration-cause-Cerebral Infarction', 'Nerve Degeneration-cause-Dementia, Vascular', 'Cerebral Infarction-recognized-Dementia, Vascular', 'Hypernatremia-linked-Death', 'Dementia-communicate-Pain', 'Neurodegenerative Diseases-needed-Alzheimer Disease', 'Neurodegenerative Diseases-needed-Parkinson Disease', 'Protein-Energy Malnutrition-contribute-Frailty', 'Protein-Energy Malnutrition-contribute-Infections', 'Protein-Energy Malnutrition-contribute-Mycoses', 'Protein-Energy Malnutrition-observed-Immunologic Deficiency Syndromes', 'Frailty-observed-Immunologic Deficiency Syndromes', 'Mycoses-include-Infections', 'Infections-include-Immunologic Deficiency Syndromes', 'Infections-observed-Immunologic Deficiency Syndromes', 'Mycoses-observed-Immunologic Deficiency Syndromes', 'Obesity-increase-Musculoskeletal Diseases', 'Neurodegenerative Diseases-exceed-Nervous System Diseases', 'Obesity-increase-Neoplasms', 'Neoplasms-exceed-Nervous System Diseases', 'Metabolic Diseases-exceed-Nervous System Diseases', 'Diabetes Mellitus-represent-Kidney Diseases', 'Atrophy-contribute-Seizures', 'Chronic Disease-explore-Death', 'Wounds and Injuries-occur-Hereditary Breast and Ovarian Cancer Syndrome', 'Aneurysm-occur-Hereditary Breast and Ovarian Cancer Syndrome', 'Cerebrovascular Disorders-contribute-Dementia', 'Cerebrovascular Disorders-conclude-Dementia', 'Thyroid Diseases-used-Alzheimer Disease', 'Immunologic Deficiency Syndromes-used-Alzheimer Disease', 'Dementia-mixed-Alzheimer Disease', 'Dementia-mixed-Cerebrovascular Disorders', 'Neoplasms-report-Muscle Weakness', 'Skin Diseases-resemble-Erythema Multiforme', 'Acute Kidney Injury-show-Eosinophilia', 'Fistula-determine-Inflammation', 'Fistula-determine-Retinal Degeneration', 'Inflammation-determine-Retinal Degeneration', 'Carcinoma, Squamous Cell-undergo-Memory Disorders', 'Friedreich Ataxia-develop-Atrophy', 'HIV Infections-share-Infections', 'Alzheimer Disease-ensue-Dementia', 'Malaria-recommended-Anemia', 'Malaria-correct-Anemia', 'Death-represent-Anemia', 'Malaria-suggest-Anemia', 'Alzheimer Disease-represent-Neurodegenerative Diseases', 'Obesity-associated-Fractures, Bone', 'Fractures, Bone-associated-Obesity', 'Prostatitis-include-Pain', 'Cataract-assigned-Vision Disorders', 'Cataract-determined-Vision Disorders', 'Cataract-reduce-Vision Disorders', 'Muscular Dystrophy, Duchenne-cause-Necrosis', 'Muscular Dystrophy, Duchenne-cause-Mobility Limitation', 'Muscular Dystrophy, Duchenne-cause-Death', 'Necrosis-include-Muscular Dystrophy, Duchenne', 'Diabetes Mellitus-report-Urinary Incontinence', 'Diabetes Mellitus-report-Vision Disorders', 'Immunologic Deficiency Syndromes-included-von Willebrand Diseases', 'Hemorrhage-followed-von Willebrand Diseases', 'Hemorrhage-followed-Immunologic Deficiency Syndromes', 'Hemorrhage-followed-Hemophilia B', 'Obesity-increase-Infertility, Female', 'Weight Loss-recommended-Infertility, Female', 'Headache-associated-Sleep Initiation and Maintenance Disorders', 'Sleep Initiation and Maintenance Disorders-associated-Headache', 'Coronary Artery Disease-identified-Sleep Initiation and Maintenance Disorders', 'Coronary Artery Disease-associated-Sleep Initiation and Maintenance Disorders', 'Sleep Initiation and Maintenance Disorders-associated-Coronary Artery Disease', 'Chronic Pain-identified-Sleep Initiation and Maintenance Disorders', 'Chronic Pain-associated-Sleep Initiation and Maintenance Disorders', 'Sleep Initiation and Maintenance Disorders-associated-Chronic Pain', 'Anorexia-identified-Sleep Initiation and Maintenance Disorders', 'Anorexia-associated-Sleep Initiation and Maintenance Disorders', 'Sleep Initiation and Maintenance Disorders-associated-Anorexia', 'Malnutrition-identified-Sleep Initiation and Maintenance Disorders', 'Malnutrition-associated-Sleep Initiation and Maintenance Disorders', 'Sleep Initiation and Maintenance Disorders-associated-Malnutrition', 'Silicosis-associated-Tuberculosis', 'Tuberculosis-associated-Silicosis', 'Silicosis-associated-Infections', 'Infections-associated-Silicosis', 'Silicosis-prioritized-Tuberculosis', 'Hepatitis B-prioritized-Tuberculosis', 'Tuberculosis-prioritized-Infections', 'Silicosis-prioritized-Infections', 'Hepatitis B-prioritized-Infections', 'Genetic Diseases, Inborn-range-Vascular Calcification', 'Alzheimer Disease-include-Thoracic Outlet Syndrome', 'Hyperglycemia-lead-Infections', 'Infections-known-Diabetes Mellitus', 'Alzheimer Disease-derived-Neurodegenerative Diseases', 'Dementia-used-Constipation', 'Dementia-live-Constipation', 'Anastomotic Leak-defined-Death', 'Diarrhea-associated-Fever', 'Fever-associated-Diarrhea', 'Choledocholithiasis-develop-Cholecystitis', 'Diabetes Mellitus-show-Atrophy', 'Diabetes Mellitus-show-Brain Infarction', 'Ventricular Dysfunction, Left-associated-Empyema, Subdural', 'Empyema, Subdural-associated-Ventricular Dysfunction, Left', 'Osteomyelitis-associated-Empyema, Subdural', 'Empyema, Subdural-associated-Osteomyelitis', 'Fever-caused-Pneumonia', 'Fever-caused-Hearing Loss', 'Otitis-lead-Empyema', 'Otitis-lead-Osteomyelitis', 'Vascular Calcification-compare-Necrosis', 'Joint Diseases-associated-Sleep Wake Disorders', 'Sleep Wake Disorders-associated-Joint Diseases', 'Urinary Incontinence-associated-Sleep Wake Disorders', 'Sleep Wake Disorders-associated-Urinary Incontinence', 'Dyslipidemias-associated-Osteoporosis', 'Osteoporosis-associated-Dyslipidemias', 'Fractures, Bone-compromised-Diabetes Mellitus', 'Fractures, Bone-compromised-Peripheral Vascular Diseases', 'Hypoglycemia-lead-Death', 'Hypoglycemia-mistaken-Nervous System Diseases', 'Hypoglycemia-include-Arrhythmias, Cardiac', 'Hypoglycemia-mistaken-Dementia', 'Hypoglycemia-include-Myocardial Infarction', 'Hypoglycemia-include-Death', 'Perceptual Disorders-mistaken-Nervous System Diseases', 'Perceptual Disorders-mistaken-Dementia', 'Neuromuscular Junction Diseases-attenuated-Pain', 'Death-include-Cerebral Hemorrhage, Traumatic', 'Pain-modify-Neuromuscular Junction Diseases', 'Coma-identified-Death', 'Kidney Diseases-identified-Death', 'Bone Neoplasms-suffer-Coronary Artery Disease', 'Coronary Artery Disease-prevent-Bone Neoplasms', 'Endocrine System Diseases-defined-Hyperglycemia', 'Death-use-Candidemia', 'Multiple Organ Failure-reveal-Death', 'Stroke-identified-Death', 'Neoplasms-report-Nervous System Diseases', 'Fibrosis-prevent-Heart Failure', 'Fractures, Bone-evaluate-Osteomyelitis', 'Meningeal Neoplasms-associated-Coronary Artery Disease', 'Coronary Artery Disease-associated-Meningeal Neoplasms', 'Stroke-demonstrated-Atherosclerosis', 'Lymphoma-drive-Neoplasms', 'Neoplasms-enhanced-Lymphoma', 'Tauopathies-recognized-Alzheimer Disease', 'Sclerosis-associated-Hypoxia', 'Hypoxia-associated-Sclerosis', 'Sclerosis-associated-Coronary Artery Disease', 'Coronary Artery Disease-associated-Sclerosis', 'Sclerosis-associated-Epilepsy', 'Epilepsy-associated-Sclerosis', 'Serotonin Syndrome-explain-Brain Damage, Chronic', 'Serotonin Syndrome-explain-Phenylketonurias', 'Phenylketonurias-support-Brain Damage, Chronic', 'Cerebral Hemorrhage-associated-Subarachnoid Hemorrhage', 'Subarachnoid Hemorrhage-associated-Cerebral Hemorrhage', 'Fibrosis-indicate-Hepatic Encephalopathy', 'Neurodegenerative Diseases-occur-Multiple Sclerosis', 'Multiple Sclerosis-transform-Chronic Disease', 'Encephalomyelitis, Autoimmune, Experimental-transform-Chronic Disease', 'Neoplasms-reduce-Hypertension', 'Lung Diseases-associated-Pneumoconiosis', 'Pneumoconiosis-associated-Lung Diseases', 'Lung Diseases-associated-Neoplasms', 'Neoplasms-associated-Lung Diseases', 'Cardiovascular Diseases-decline-Death', 'Hypertriglyceridemia-see-Atrioventricular Block', 'Nervous System Diseases-interpreted-Hepatic Encephalopathy', 'Liver Failure, Acute-display-Nervous System Diseases', 'Fibrosis-display-Nervous System Diseases', 'Hepatic Encephalopathy-display-Nervous System Diseases', 'Periodontal Diseases-associated-Alzheimer Disease', 'Alzheimer Disease-associated-Periodontal Diseases', 'Alzheimer Disease-diagnosed-Dementia', 'Atrophy-observed-Renal Insufficiency, Chronic', 'Atrophy-observed-Chronic Kidney Disease-Mineral and Bone Disorder', 'Inflammation-treat-Cardiovascular Diseases', 'Asthma-differentiate-Obesity', 'Mitochondrial Diseases-implicated-Pulmonary Disease, Chronic Obstructive', 'Kidney Diseases-include-Fatigue', 'Kidney Diseases-include-Anorexia', 'Kidney Diseases-include-Nausea', 'Kidney Diseases-include-Vomiting', 'Kidney Diseases-include-Pruritus', 'Spinocerebellar Degenerations-compensate-Refractive Errors', 'Diabetes Mellitus, Type 2-create-Nerve Degeneration', 'Diabetes Mellitus, Type 2-permit-Alzheimer Disease', 'Diabetes Mellitus, Type 2-permit-Memory Disorders', 'Nerve Degeneration-identified-Alzheimer Disease', 'Nerve Degeneration-identified-Memory Disorders', 'Nocturia-predict-Polyuria', 'Chronic Disease-triggered-Arbovirus Infections', 'Sepsis-considered-Death', 'Myasthenia Gravis-lead-Respiratory Insufficiency', 'Death-experience-Fistula', 'Fistula-followed-Death', 'Arteriovenous Fistula-identified-Death', 'Sarcopenia-recognized-Diabetes Mellitus', 'Heart Failure-treat-Hypertension', 'Sarcopenia-applied-Deglutition Disorders', 'Deglutition Disorders-show-Cough', 'Alzheimer Disease-disentangle-AIDS Arteritis, Central Nervous System', 'AIDS Arteritis, Central Nervous System-leverage-Alzheimer Disease', 'Immunologic Deficiency Syndromes-correlate-Coronary Artery Disease', 'Immunologic Deficiency Syndromes-correlate-Atherosclerosis', 'Immunologic Deficiency Syndromes-correlate-Myocardial Infarction', 'Immunologic Deficiency Syndromes-correlate-Cardiomyopathy, Hypertrophic', 'Psychomotor Agitation-reduce-Dementia', 'Alzheimer Disease-associated-Obesity', 'Obesity-associated-Alzheimer Disease', 'Fractures, Open-correlate-Death', 'Fractures, Open-correlated-Death', 'Stroke-report-Coronary Artery Disease', 'Ischemia-report-Coronary Artery Disease', 'Fractures, Open-show-Death', 'Atrial Fibrillation-develop-Dementia', 'Alzheimer Disease-become-Dementia', 'Obesity-discussed-Cardiovascular Diseases', 'Dementia-prevent-Stroke', 'Dementia-include-Cerebrovascular Disorders', 'Pain-caused-Osteoarthritis', 'Alzheimer Disease-quantified-Plaque, Amyloid', 'Hypertension-related-Renal Insufficiency, Chronic', 'Diabetes Mellitus-related-Renal Insufficiency, Chronic', 'Renal Insufficiency, Chronic-related-Hypertension', 'Parkinson Disease-experience-Dementia', 'Death-predict-Bone Neoplasms', 'Bone Neoplasms-related-Death', 'Muscular Dystrophy, Duchenne-related-Death', 'Bone Neoplasms-drive-Death', 'Prader-Willi Syndrome-implicate-Brain Diseases', 'Renal Insufficiency, Chronic-associated-Urologic Diseases', 'Urologic Diseases-associated-Renal Insufficiency, Chronic', 'Renal Insufficiency, Chronic-associated-Short Bowel Syndrome', 'Short Bowel Syndrome-associated-Renal Insufficiency, Chronic', 'Urologic Diseases-associated-Sepsis', 'Sepsis-associated-Urologic Diseases', 'Urologic Diseases-associated-Short Bowel Syndrome', 'Short Bowel Syndrome-associated-Urologic Diseases', 'Fractures, Bone-reduce-Hip Fractures', 'Inflammation-underlie-Kidney Diseases', 'Mitochondrial Diseases-implicated-Kidney Diseases', 'Mitochondrial Diseases-underlie-Kidney Diseases', 'Obesity-identified-Sarcopenia', 'Neoplasms-include-Angina, Stable', 'Muscular Dystrophy, Duchenne-limit-Fractures, Bone', 'Tooth Diseases-associated-Neoplasms', 'Neoplasms-associated-Tooth Diseases', 'Hepatitis B-include-Hyperhomocysteinemia', 'Foot Ulcer-measured-Peripheral Arterial Disease', 'Breast Neoplasms-diagnosed-Neoplasm Invasiveness', 'Neoplasm Invasiveness-develop-Breast Neoplasms', 'Cerebral Infarction-associated-Myocardial Infarction', 'Myocardial Infarction-associated-Cerebral Infarction', 'Embolism-associated-Myocardial Infarction', 'Myocardial Infarction-associated-Embolism', 'Hypertension-associated-Myocardial Infarction', 'Myocardial Infarction-associated-Hypertension', 'Death-treated-Thyroid Neoplasms', 'Muscle Weakness-treat-Fractures, Bone', 'HIV Infections-associated-Autoimmune Diseases', 'Autoimmune Diseases-associated-HIV Infections', 'Opportunistic Infections-increase-HIV Infections', 'Crohn Disease-associated-Tuberculosis', 'Tuberculosis-associated-Crohn Disease', 'Leukemia, Lymphoid-associated-Pneumonia, Pneumocystis', 'Pneumonia, Pneumocystis-associated-Leukemia, Lymphoid', 'Leukemia, Lymphoid-treat-Neoplasms', 'Fever-test-Infections', 'Fever-associated-Arthralgia', 'Arthralgia-associated-Fever', 'Fever-associated-Myalgia', 'Myalgia-associated-Fever', 'Signs and Symptoms, Respiratory-associated-Cough', 'Cough-associated-Signs and Symptoms, Respiratory', 'Respiratory Distress Syndrome-complicated-Pneumonia, Aspiration', 'Glomerulonephritis-display-Death', 'Glomerulonephritis-display-Lupus Nephritis', 'Glomerulonephritis-display-Kidney Failure, Chronic', 'Death-display-Lupus Nephritis', 'Death-display-Kidney Failure, Chronic', 'Lupus Nephritis-display-Kidney Failure, Chronic', 'Death-account-Proteinuria', 'Lupus Nephritis-account-Proteinuria', 'Infections-compare-Hip Fractures', 'Sleep Initiation and Maintenance Disorders-calculate-Stroke', 'Death-calculate-Stroke', 'Ischemia-compare-Acute Coronary Syndrome', 'Hemorrhage-compare-Acute Coronary Syndrome', 'Ischemia-be coronary-Hemorrhage', 'Ischemia-reduce-Hemorrhage', 'AIDS Arteritis, Central Nervous System-link-Brain Injuries', 'AIDS Arteritis, Central Nervous System-link-HIV Infections', 'Stroke-diagnosed-Ischemia', 'Endocarditis-worsen-Tricuspid Valve Insufficiency', 'Sexual Dysfunction, Physiological-related-Neurologic Manifestations', 'Neurodegenerative Diseases-include-Parkinson Disease, Secondary', 'Tuberculosis-vaccinate-Death', 'Osteoporosis-become-Rheumatic Diseases', 'Osteoporosis-become-Arthritis, Rheumatoid', 'Osteoporosis-become-Spondylarthropathies', 'Osteoporosis-become-Lupus Erythematosus, Systemic', 'Somatosensory Disorders-cause-Death', 'Somatosensory Disorders-identify-Dementia', 'Death-identify-Dementia', 'Death-occur-Wounds and Injuries', 'Dementia-occur-Wounds and Injuries', 'Stroke-evaluate-Fractures, Bone', 'Death-exclude-Chronic Disease', 'Inflammation-protect-Colonic Diseases', 'Osteoporosis-cause-Gastrointestinal Diseases', 'Alzheimer Disease-accumulating-Headache Disorders, Secondary', 'Neoplasms-associated-Skin Neoplasms', 'Skin Neoplasms-associated-Neoplasms', 'Neoplasms-associated-Carcinoma, Merkel Cell', 'Carcinoma, Merkel Cell-associated-Neoplasms', 'Diverticular Diseases-result-Shock, Hemorrhagic', 'Diverticulitis, Colonic-cause-Fistula', 'Diabetes Mellitus-face-Death', 'Death-face-Diabetes Mellitus', 'Atherosclerosis-evaluate-Breast Neoplasms', 'Hip Fractures-malnourished-Death', 'Atherosclerosis-determined-Plaque, Atherosclerotic', 'Fragile X Syndrome-report-Death', 'Dwarfism, Pituitary-show-Cardiovascular Diseases', 'Dwarfism, Pituitary-show-Diabetes Mellitus', 'Metabolic Diseases-affected-Cardiovascular Diseases', 'Edema-related-Stroke', 'Edema-include-Stroke', 'Edema-influence-Stroke', 'Cardiovascular Diseases-investigate-Death', 'Infections-underlie-Chronic Disease', 'Infections-include-Inflammation', 'Chronic Disease-underlie-Inflammation', 'Chronic Disease-underlie-Immunologic Deficiency Syndromes', 'Immunologic Deficiency Syndromes-include-Infections', 'Infections-occur-Arbovirus Infections', 'Arbovirus Infections-use-Respiratory Syncytial Virus Infections', 'Psychomotor Agitation-caused-Psychoses, Substance-Induced', 'Psychoses, Substance-Induced-induced-Spasm', 'Psychoses, Substance-Induced-treat-Spasm', 'Psychoses, Substance-Induced-treat-Pain', 'Infections-observe-Babesiosis', 'Infections-prevent-Cardiomyopathies', 'Parasitemia-reduce-Infections', 'Parasitemia-increase-Arthritis', 'Infections-increase-Arthritis', 'Infections-observed-Inflammation', 'Prostatic Hyperplasia-restrain-Prostatic Neoplasms', 'Hypoxia-follow-Apnea', 'Language Development Disorders-caused-Hearing Loss', 'Macular Degeneration-exacerbated-Obesity', 'Atrial Fibrillation-describe-Syncope', 'Atrial Fibrillation-underlie-Syncope', 'Atrial Fibrillation-receive-Syncope', 'Arrhythmias, Cardiac-based-Syncope', 'Death-suffer-Pancreatitis', 'Sarcopenia-considered-Deglutition Disorders', 'Deglutition Disorders-show-Sarcopenia', 'Hypothalamic Neoplasms-undergo-Hypertrophy', 'Deglutition Disorders-contribute-Pneumonia', 'Spinal Cord Diseases-become-Spinal Cord Injuries', 'Liver Cirrhosis-relieve-Chemical and Drug Induced Liver Injury', 'Death-treated-Fractures, Bone', 'Colorectal Neoplasms-lie-Death', 'Death-assessed-Neoplasms', 'Metabolic Syndrome-indicate-Metabolic Diseases', 'HIV Infections-indicate-Metabolic Diseases', 'Breast Neoplasms-incorporate-Drug-Related Side Effects and Adverse Reactions', 'Cerebral Infarction-sampled-Stroke', 'Fragile X Syndrome-coincide-Chronic Disease', 'Cerebral Small Vessel Diseases-relate-Hypertension', 'Hypertension-obtained-Dementia', 'Hypertension-obtained-Stroke', 'Hypertension-aged-Dementia', 'Fragile X Syndrome-ease-Diabetes Mellitus', 'Thyroid Diseases-arise-Hypothyroidism', 'Thyroid Diseases-lead-Fractures, Bone', 'Thyroid Diseases-lead-Death', 'Thyroid Diseases-treated-Hypothyroidism', 'Thyroid Diseases-lead-Arrhythmias, Cardiac', 'Hypothyroidism-lead-Arrhythmias, Cardiac', 'Respiratory Insufficiency-treated-Respiratory Distress Syndrome', 'Respiratory Distress Syndrome-treat-Obesity', 'Lung Injury-associated-Pulmonary Edema', 'Pulmonary Edema-associated-Lung Injury', 'Lung Injury-associated-Respiratory Insufficiency', 'Respiratory Insufficiency-associated-Lung Injury', 'Fibromyalgia-experience-Fatigue', 'Multiple Sclerosis-experience-Fatigue', 'Brain Ischemia-induced-Heart Arrest', 'Brain Ischemia-induced-Cerebral Infarction', 'Renal Insufficiency, Chronic-prevent-Hyponatremia', 'Thrombocytopenia-characterized-Purpura', 'Edema-suffer-Neurotoxicity Syndromes', 'Hematoma-suffer-Neurotoxicity Syndromes', 'Malocclusion-used-Dementia', 'Malocclusion-identify-Dementia', 'Neoplasms-range-Pulmonary Disease, Chronic Obstructive', 'Ulcer-increase-Venous Thrombosis', 'Cardiovascular Diseases-range-Pulmonary Disease, Chronic Obstructive', 'Hypertension-range-Pulmonary Disease, Chronic Obstructive', 'Diabetes Mellitus-range-Pulmonary Disease, Chronic Obstructive', 'Pain-include-Ulcer', 'Leg Ulcer-known-Pain', 'Ulcer-experience-Pain', 'Hemorrhage-defined-Death', 'Blepharospasm-related-Wounds and Injuries', 'HIV Infections-transform-Infections', 'HIV Infections-transform-Death', 'Infections-transform-Death', 'Carcinoma, Basal Cell-including-Skin Neoplasms', 'Carcinoma, Squamous Cell-including-Skin Neoplasms', 'Carcinoma, Squamous Cell-associated-HIV Infections', 'HIV Infections-associated-Carcinoma, Squamous Cell', 'Neoplasms-associated-Obesity', 'Obesity-associated-Neoplasms', 'Neoplasms-compared-Death', 'Death-continue-Neoplasms', 'Coronary Artery Disease-use-Angina Pectoris', 'Infections-infect-Lung Diseases', 'Rhabdomyolysis-include-Myalgia', "Hallermann's Syndrome-show-Craniofacial Abnormalities", "Hallermann's Syndrome-show-Eye Abnormalities", "Hallermann's Syndrome-show-Growth Disorders", 'Cerebrovascular Disorders-increase-Stroke', 'Seizures-suffer-Diabetes Mellitus', 'Alzheimer Disease-trigger-Cerebrovascular Disorders', 'Fractures, Bone-improve-Movement Disorders', 'Parkinson Disease-become-Heredodegenerative Disorders, Nervous System', 'Postpericardiotomy Syndrome-contribute-Death', 'Postpericardiotomy Syndrome-associated-Death', 'Death-associated-Postpericardiotomy Syndrome', 'Venous Thromboembolism-result-Death', 'Heart Failure-affected-Death', 'Heart Failure-suffer-Metabolic Diseases', 'Neoplasms-suffer-Metabolic Diseases', 'Ataxia-adjusting-Obesity', 'Infections-associated-HIV Infections', 'HIV Infections-associated-Infections', 'Hepatolenticular Degeneration-mitigate-Drug-Related Side Effects and Adverse Reactions', 'Vision Disorders-contribute-Sleep Wake Disorders', 'Coronary Artery Disease-present-Fatigue', 'Fatigue-include-Atrial Fibrillation', 'Muscle Weakness-include-Atrial Fibrillation', 'Fatigue-include-Ischemia', 'Muscle Weakness-include-Ischemia', 'Hypertension-present-Fatigue', 'Death-occur-Heart Failure', 'Death-present-Obesity', 'Dementia-treated-Dehydration', 'Dementia-treated-Infections', 'Dementia-treated-Fractures, Bone', 'Dementia-treated-Neoplasms', 'Dementia-treated-Musculoskeletal Diseases', 'Stroke-confer-Hypertension', 'Diabetes Mellitus-confer-Hypertension', 'Bone Neoplasms-reduce-Osteoporotic Fractures', 'Metabolic Syndrome-develop-Coronary Artery Disease', 'Metabolic Syndrome-develop-Hypertension', 'Metabolic Syndrome-develop-Diabetes Mellitus', 'Hip Fractures-included-Wounds and Injuries', 'Metabolic Syndrome-increase-Hyperuricemia', 'Cardiovascular Diseases-attenuate-Sarcopenia', 'Osteoarthritis-increase-Cardiac Output, Low', 'Periodontal Diseases-exhibit-Periodontitis', 'Arthralgia-increase-Cardiac Output, Low', 'Muscle Weakness-increase-Cardiac Output, Low', 'Sensation Disorders-increase-Cardiac Output, Low', 'Hemorrhage-require-Stroke', 'Atrial Fibrillation-require-Stroke', 'Diabetes Mellitus-reduce-Tuberculosis', 'Heart Failure-manifest-Dyspnea', 'Tachycardia-consider-Heart Failure', 'Ventricular Dysfunction, Left-caused-Tachycardia', 'Tachycardia-underlie-Heart Diseases', 'Abnormalities, Drug-Induced-require-Liver Failure', 'Biliary Atresia-develop-Liver Failure', 'Gastrointestinal Diseases-focus-Biliary Atresia', 'Neoplasms-expressed-Sarcopenia', 'Sarcopenia-shown-Neoplasms', 'Drug-Related Side Effects and Adverse Reactions-shown-Neoplasms', 'Atrial Fibrillation-use-Stroke', 'Adenocarcinoma of Lung-figured-Carcinoma, Squamous Cell', 'Lung Neoplasms-accounted-Death', 'Death-used-Lymphoma, Non-Hodgkin', 'Death-estimate-Lymphoma, Non-Hodgkin', 'Lymphoma, Non-Hodgkin-exceed-Death', 'Wounds and Injuries-lead-Fractures, Bone', 'Fractures, Bone-caused-Oculocerebrorenal Syndrome', 'Oculocerebrorenal Syndrome-caused-Ankle Fractures', 'Musculoskeletal Pain-assessed-Pain', 'Musculoskeletal Pain-assessed-Back Pain', 'Sarcopenia-affected-Renal Insufficiency, Chronic', 'Arthritis-include-Neurodegenerative Diseases', 'Pain-assessed-Dementia', 'Blood Protein Disorders-involve-Idiopathic Pulmonary Fibrosis', 'Seizures-experience-Status Epilepticus', 'Neoplasms-relate-Arbovirus Infections', 'Periprosthetic Fractures-associate-Death', 'Death-associate-Periprosthetic Fractures', 'Amyloidosis-identify-Alzheimer Disease', 'Death-exhibit-Myocardial Infarction', 'Polyneuropathies-associated-Sleep Apnea Syndromes', 'Sleep Apnea Syndromes-associated-Polyneuropathies', 'Ovarian Neoplasms-indicate-Dysgeusia', 'Calcinosis-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-Calcinosis', 'Calcinosis-associated-Renal Insufficiency, Chronic', 'Renal Insufficiency, Chronic-associated-Calcinosis', 'Cough-show-Pneumonia, Aspiration', 'Deglutition Disorders-lead-Pneumonia, Aspiration', 'Alzheimer Disease-rated-Dementia', 'Pain-provide-Neoplasms', 'Neurodegenerative Diseases-accompanied-Blood Protein Disorders', 'Proteostasis Deficiencies-result-Blood Protein Disorders', 'Hypercholesterolemia-followed-Hypertension', 'Retinal Diseases-evaluate-Diabetes Mellitus', 'Liver Cirrhosis-associated-Gastrointestinal Hemorrhage', 'Gastrointestinal Hemorrhage-associated-Liver Cirrhosis', 'Hearing Loss-hear-Cardiovascular Diseases', 'Alzheimer Disease-sustain-Infarction', 'Alzheimer Disease-sustain-Cerebral Infarction', 'Infarction-sustain-Cerebral Infarction', 'Diabetes Mellitus-considered-Neoplastic Syndromes, Hereditary', 'Adrenal Insufficiency-show-Sarcopenia', 'Pneumonia-increase-Hip Fractures', 'Colitis, Ulcerative-mimic-Gastrointestinal Diseases', 'Seroma-experience-Hematoma', 'Seroma-experience-Infections', 'Seroma-experience-Necrosis', 'Seroma-develop-Venous Thrombosis', 'Seroma-experience-Musculoskeletal Diseases', 'Hematoma-experience-Infections', 'Hematoma-experience-Necrosis', 'Hematoma-develop-Venous Thrombosis', 'Hematoma-experience-Musculoskeletal Diseases', 'Infections-develop-Venous Thrombosis', 'Infections-experience-Musculoskeletal Diseases', 'Necrosis-develop-Venous Thrombosis', 'Necrosis-experience-Musculoskeletal Diseases', 'Venous Thrombosis-experience-Musculoskeletal Diseases', 'Myelodysplastic Syndromes-progress-Leukemia, Myeloid, Acute', 'Myelodysplastic Syndromes-become-Leukemia, Myeloid, Acute', 'Infarction-predominate-Cerebral Amyloid Angiopathy', 'Dementia, Vascular-predominate-Cerebral Amyloid Angiopathy', 'Pain-affect-Peripheral Arterial Disease', 'Anemia, Aplastic-include-Myelodysplastic Syndromes', 'Atrial Fibrillation-increase-Thrombosis', 'Sarcoma-related-Neoplasms', 'Encephalitis, California-test-Urinary Retention', 'Dementia-exclude-Psychomotor Disorders', 'Atherosclerosis-associate-Aneurysm', 'Aneurysm-associate-Atherosclerosis', 'Erythema-base-Edema', 'Parkinson Disease, Secondary-assessed-Parkinsonian Disorders', 'Parkinson Disease, Secondary-defined-Parkinsonian Disorders', 'Neurodegenerative Diseases-accompanied-Hepatomegaly', 'Death-code-Dementia', 'Death-derived-Dementia', 'Brain Injuries, Traumatic-cause-Spinal Cord Injuries', 'Osteoporosis-range-Fractures, Bone', 'Tuberculosis-include-Dyskinesias', 'Infections-include-Dyskinesias', 'Tuberculosis-include-Headache Disorders', 'Infections-include-Headache Disorders', 'Infections-include-Tuberculosis', 'Wounds and Injuries-highlight-Death', 'Endocarditis-demonstrate-Infections', 'Epilepsy-contribute-Nerve Degeneration', 'Inflammation-perpetuate-Immune System Diseases', 'Sleep Wake Disorders-correlated-Migraine Disorders', 'Diabetes Mellitus-examine-Obesity', 'Epilepsy-present-Status Epilepticus', 'Fever-induced-Ankle Injuries', 'Sleep Wake Disorders-determined-Respiratory Insufficiency', 'Cardiovascular Diseases-recommended-Sleep Wake Disorders', 'Hyperkinesis-link-Dementia', 'Neuralgia-treat-Epilepsy', 'Mastocytosis, Systemic-control-Dry Eye Syndromes', 'Weight Gain-lead-Tuberculosis', 'Infections-modeling-Inflammation', 'Obesity-cause-Death', 'Metabolic Diseases-improve-Neurodegenerative Diseases', 'Death-contribute-Cystic Fibrosis', 'Metabolic Diseases-infiltrated-Diabetes Mellitus', 'Metabolic Diseases-lead-Inflammation', 'Metabolic Diseases-infiltrated-Fibrosis', 'Diabetes Mellitus-lead-Inflammation', 'Diabetes Mellitus-infiltrated-Fibrosis', 'Demyelinating Diseases-follow-Multiple Sclerosis', 'Demyelinating Diseases-found-Multiple Sclerosis', 'Sleep Deprivation-associated-Obesity', 'Obesity-associated-Sleep Deprivation', 'Gait Disorders, Neurologic-develop-Death', 'Dementia-develop-Death', 'Stroke-develop-Death', 'Hypertrophy-found-Cerebral Small Vessel Diseases', 'Pain-restore-Hip Fractures', 'Pain-need-Death', 'Inflammation-linked-Superinfection', 'Infections-correlate-Death', 'Fatigue-coincide-Chronic Disease', 'Hyponatremia-investigated-Pituitary Neoplasms', 'Hyponatremia-undergo-Pituitary Neoplasms', 'Motion Sickness-indicate-Coronary Artery Disease', 'Pneumococcal Infections-relate-Inflammation', 'Pneumococcal Infections-relate-Pneumonia', 'Heart Failure-impact-Tooth, Impacted', 'Heart Failure-fit-Seizures', 'Surgical Wound Infection-improve-Hip Fractures', 'Infections-replace-Hypothermia', 'Fever-replace-Hypothermia', 'Hypothermia-accompany-Infections', 'Hypothermia-accompany-Fever', 'Ulcer-know-Pain', 'Pain-observed-Syncope', 'Pain-observed-Dyspnea', 'Urinary Incontinence-use-Constipation', 'Neoplasms-show-Small Cell Lung Carcinoma', 'Fever-seen-Communicable Diseases', 'Hypopituitarism-perform-Neoplasms', 'Hypopituitarism-mistaken-Lethargy', 'Hypopituitarism-mistaken-Vision Disorders', 'Death-required-Hypopituitarism', 'Death-required-Neoplasm Metastasis', 'Stomach Neoplasms-recruited-Neoplasms', 'Hip Fractures-treated-Jacobsen Distal 11q Deletion Syndrome', 'Thymus Neoplasms-associated-Atherosclerosis', 'Atherosclerosis-associated-Thymus Neoplasms', 'Coronary Artery Disease-mediated-Atherosclerosis', 'HIV Infections-cause-Acquired Immunodeficiency Syndrome', 'Acquired Immunodeficiency Syndrome-associated-Carcinoma, Hepatocellular', 'Carcinoma, Hepatocellular-associated-Acquired Immunodeficiency Syndrome', 'Acquired Immunodeficiency Syndrome-cause-Papillomavirus Infections', 'Acquired Immunodeficiency Syndrome-associated-Uterine Cervical Neoplasms', 'Uterine Cervical Neoplasms-associated-Acquired Immunodeficiency Syndrome', 'Hepatitis C-associated-Carcinoma, Hepatocellular', 'Carcinoma, Hepatocellular-associated-Hepatitis C', 'Sleep Wake Disorders-occur-Cutaneous Fistula', 'Hematoma, Subdural, Chronic-referred-Wounds and Injuries', 'Genetic Diseases, Inborn-related-Vestibular Diseases', 'Heart Failure-grow-Heart Diseases', 'Carcinoma, Non-Small-Cell Lung-based-Drug-Related Side Effects and Adverse Reactions', 'Hearing Loss, Central-alleviate-Tinnitus', 'Aneurysm-emphasize-Hyperglycemia', 'Obesity-emphasize-Hyperglycemia', 'Cushing Syndrome-cured-Hypertension', 'Inflammation-confer-Fractures, Bone', 'Kidney Failure, Chronic-confer-Fractures, Bone', 'Fibrosis-associated-Hypotension', 'Hypotension-associated-Fibrosis', 'Cardiomyopathy, Hypertrophic-associated-Hypotension', 'Hypotension-associated-Cardiomyopathy, Hypertrophic', 'Progeria-characterized-Fibrosis', 'Aging, Premature-characterized-Cardiovascular Diseases', 'Aging, Premature-characterized-Fibrosis', 'Endophthalmitis-related-Cataract', 'Brain Diseases-indicate-Atrophy', 'Dementia-indicate-Atrophy', 'Chemical and Drug Induced Liver Injury-delay-Memory Disorders', 'Periodontitis-correlate-Inflammation', 'Periodontitis-correlate-Bone Neoplasms', 'Inflammation-correlate-Communicable Diseases', 'Bone Neoplasms-correlate-Communicable Diseases', 'Periodontitis-lead-Jaw, Edentulous', 'Periodontitis-linked-Fractures, Spontaneous', 'Periodontitis-linked-Diabetes Mellitus', 'Periodontitis-linked-Cardiovascular Diseases', 'Jaw, Edentulous-linked-Diabetes Mellitus', 'Jaw, Edentulous-linked-Cardiovascular Diseases', 'Fractures, Spontaneous-linked-Diabetes Mellitus', 'Fractures, Spontaneous-linked-Cardiovascular Diseases', 'Immune System Diseases-activated-Obesity', 'Neoplasms-activated-Obesity', 'Obesity-associated-Parkinson Disease', 'Parkinson Disease-associated-Obesity', 'Pneumonia-follow-Infections', 'Obesity-highlight-Neoplasms', 'Neoplasms-understood-Obesity', 'Infections-demonstrate-Weight Loss', 'Huntington Disease-coupled-Neurodegenerative Diseases', 'Atrial Fibrillation-remain-Stroke', 'Fecal Incontinence-extend-Dehydration', 'Drug-Related Side Effects and Adverse Reactions-prevent-Hodgkin Disease', 'Parkinson Disease-compare-Parkinsonian Disorders', 'Neoplasms, Cystic, Mucinous, and Serous-display-Carcinosarcoma', 'Metabolic Syndrome-hung-Immunologic Deficiency Syndromes', 'Cerebrovascular Disorders-predict-Unconsciousness', 'Cerebrovascular Disorders-predict-Craniocerebral Trauma', 'Sleep Initiation and Maintenance Disorders-result-Amnesia', 'Sleep Initiation and Maintenance Disorders-result-Nervous System Diseases', 'Amnesia-result-Nervous System Diseases', 'Werner Syndrome-characterized-Atherosclerosis', 'Infarction-lead-Nerve Degeneration', 'Neurodegenerative Diseases-detected-Stroke', 'Deglutition Disorders-avoid-Respiratory Aspiration', 'Nocturia-exhibit-Death', 'Death-predict-Acute Disease', 'Ventricular Dysfunction, Left-exacerbated-Atrial Fibrillation', 'Ventricular Dysfunction, Left-result-Heart Failure', 'Hypotension-exacerbated-Atrial Fibrillation', 'Hypotension-result-Heart Failure', 'Atrial Fibrillation-exacerbated-Heart Failure', 'Coronary Artery Disease-include-Atrial Fibrillation', 'Atrial Fibrillation-protect-Ventricular Fibrillation', 'Heart Diseases-protect-Ventricular Fibrillation', 'Atrial Remodeling-protect-Ventricular Fibrillation', 'Hypertension-combine-Diabetes Mellitus', 'Pneumonia-associated-Respiratory Tract Infections', 'Respiratory Tract Infections-associated-Pneumonia', 'Muscle Rigidity-linked-Neoplasms', 'Neoplasms-show-Adenocarcinoma', 'Hemorrhage-resemble-von Willebrand Diseases', 'Malformations of Cortical Development-include-Cerebral Small Vessel Diseases', 'Adenocarcinoma-identified-Lung Diseases', 'Death-complicate-Cachexia', 'Short Bowel Syndrome-complicate-Cachexia', 'Fractures, Bone-associated-Breast Neoplasms, Male', 'Breast Neoplasms, Male-associated-Fractures, Bone', 'Hernia, Obturator-complicate-Cachexia', 'Lung Diseases-complicate-Cachexia', 'Lung Diseases-complicate-Adenocarcinoma', 'Cachexia-complicate-Adenocarcinoma', 'Dysgeusia-improve-Pancreatic Neoplasms', 'Dry Eye Syndromes-share-Osteoporosis', 'Heart Arrest-characterized-Hypertrophy', 'Dry Eye Syndromes-result-Vision Disorders', 'Osteoporosis-associated-Dry Eye Syndromes', 'Dry Eye Syndromes-associated-Osteoporosis', 'Dry Eye Syndromes-increase-Fractures, Bone', 'Dry Eye Syndromes-exist-Osteoporosis', 'Vision Disorders-increase-Fractures, Bone', 'Vision Disorders-exist-Osteoporosis', 'Fractures, Bone-exist-Osteoporosis', 'Osteoporosis-develop-Dry Eye Syndromes', 'Dry Eye Syndromes-diagnosed-Osteoporosis', 'Fractures, Bone-include-Neoplasms', 'Movement Disorders-explained-Spinocerebellar Degenerations', 'Neutropenia-occur-Sepsis', 'Neutropenia-occur-Death', 'Hypertension-develop-Cardiovascular Diseases', 'Hypertension-develop-Neurodegenerative Diseases', 'Refractive Errors-fall-Cardiac Output, Low', 'Drug-Related Side Effects and Adverse Reactions-regulated-Neurotoxicity Syndromes', 'Death-follow-Hematoma, Subdural, Acute', 'Death-influenced-Nervous System Diseases', 'Hematoma, Subdural, Acute-influenced-Nervous System Diseases', 'Atrophy-associated-Dyspareunia', 'Dyspareunia-associated-Atrophy', 'Atrophy-associated-Xerostomia', 'Xerostomia-associated-Atrophy', 'Atrophy-associated-Infections', 'Infections-associated-Atrophy', 'Atrophy-associated-Urinary Incontinence', 'Urinary Incontinence-associated-Atrophy', 'Osteoporosis-linked-Fractures, Bone', 'Death-linked-Fractures, Bone', 'Osteoporotic Fractures-lowering-Death', 'Osteoporotic Fractures-seen-Fractures, Bone', 'Death-seen-Fractures, Bone', 'Bone Neoplasms-enhance-Bone Resorption', 'Obesity-delve-Obesity, Metabolically Benign', 'Acidosis-associated-Bone Diseases, Metabolic', 'Bone Diseases, Metabolic-associated-Acidosis', 'Acidosis-associated-Diabetes Mellitus, Type 2', 'Diabetes Mellitus, Type 2-associated-Acidosis', 'Acidosis-associated-Hypertension', 'Hypertension-associated-Acidosis', 'Venous Thromboembolism-associated-Hypertension', 'Hypertension-associated-Venous Thromboembolism', 'Venous Thromboembolism-associated-Cerebrovascular Disorders', 'Cerebrovascular Disorders-associated-Venous Thromboembolism', 'Sarcopenia-correlated-Death', 'Sarcopenia-correlated-Stomach Neoplasms', 'Hypertension-co-exist-Obesity', 'Bacteremia-place-Death', 'Brain Diseases-provide-Alzheimer Disease', 'Sleep Wake Disorders-include-Migraine Disorders', 'Dyspnea-include-Migraine Disorders', 'Disorders of Excessive Somnolence-include-Migraine Disorders', 'Myoclonus-seen-Renal Insufficiency', 'Myoclonus-develop-Renal Insufficiency', 'Chronic Pain-treat-Acne Vulgaris', 'Dermatitis-treat-Acne Vulgaris', 'Lupus Erythematosus, Systemic-treat-Acne Vulgaris', 'Psoriasis-treat-Acne Vulgaris', 'Epidermolysis Bullosa-treat-Acne Vulgaris', 'Chronic Pain-treat-Dermatitis, Contact', 'Dermatitis-treat-Dermatitis, Contact', 'Lupus Erythematosus, Systemic-treat-Dermatitis, Contact', 'Psoriasis-treat-Dermatitis, Contact', 'Epidermolysis Bullosa-treat-Dermatitis, Contact', 'Chronic Pain-treat-Dermatitis', 'Lupus Erythematosus, Systemic-treat-Dermatitis', 'Psoriasis-treat-Dermatitis', 'Epidermolysis Bullosa-treat-Dermatitis', 'Hepatitis B-associated-Infections', 'Infections-associated-Hepatitis B', 'Infections-associated-Carcinoma, Hepatocellular', 'Carcinoma, Hepatocellular-associated-Infections', 'Peripheral Arterial Disease-cause-Pain', 'Peripheral Arterial Disease-known-Intermittent Claudication', 'Peripheral Arterial Disease-cause-Gangrene', 'Pain-known-Intermittent Claudication', 'Pain-cause-Gangrene', 'Intermittent Claudication-known-Gangrene', 'Peripheral Arterial Disease-known-Limb Deformities, Congenital', 'Ulcer-cause-Intermittent Claudication', 'Pupil Disorders-reveal-Edema', 'Arbovirus Infections-play-Neuromyelitis Optica', 'Seizures-improve-Obesity', 'Seizures-reduce-Cardiovascular Diseases', 'Cardiovascular Diseases-live-Diabetes Mellitus', 'Neoplasms-live-Diabetes Mellitus', 'Diabetes Mellitus-live-Hypertension', 'Atrial Fibrillation-reduced-Pain', 'Alzheimer Disease-compare-Lewy Body Disease', 'Alzheimer Disease-use-Dementia', 'Lewy Body Disease-use-Dementia', 'Cataract-include-Anophthalmos', 'Diabetes Mellitus-include-Anophthalmos', 'Anophthalmos-analyzed-Osteoporosis', 'Cataract-analyzed-Osteoporosis', 'Glaucoma, Open-Angle-analyzed-Osteoporosis', 'Diabetes Mellitus-analyzed-Osteoporosis', 'Osteoporosis-show-Glycogen Storage Disease Type II', 'Osteoporosis-show-Anophthalmos', 'Ulcer-rule-Candidiasis', 'Pain-suffer-Dementia', 'Alzheimer Disease-predisposed-Seizures', 'Pain-assess-Dementia', 'Dementia-make-Pain', 'Dementia-expected-Pain', 'Hypothalamic Diseases-play-Alzheimer Disease', 'Sleep Wake Disorders-observed-Alzheimer Disease', 'Pneumonia-developed-Pulmonary Embolism', 'Pneumonia-developed-Tuberculosis, Pulmonary', 'Kidney Diseases-associated-Long QT Syndrome', 'Long QT Syndrome-associated-Kidney Diseases', 'Renal Insufficiency, Chronic-related-Kidney Diseases', 'Hypogonadism-arise-Hypothalamic Neoplasms', 'Vulvovaginitis-improve-Atrophic Vaginitis', 'Pain-follow-Disease', 'Pain-include-Disease', 'Pain-follow-Fractures, Bone', 'Pain-follow-Osteoarthritis', 'Pain-follow-Low Back Pain', 'Pain-follow-Fibrous Dysplasia of Bone', 'Pain-follow-Bone Diseases', 'Pain-follow-Anemia, Sickle Cell', 'Pain-follow-Bone Neoplasms', 'Fractures, Bone-include-Disease', 'Osteoarthritis-include-Disease', 'Low Back Pain-include-Disease', 'Fibrous Dysplasia of Bone-include-Disease', 'Bone Diseases-include-Disease', 'Anemia, Sickle Cell-include-Disease', 'Bone Neoplasms-include-Disease', 'Cardiovascular Diseases-quantified-Hypertension', 'Pneumonia-observed-Infections', 'Sleep Wake Disorders-use-Sleep Apnea Syndromes', 'Dyslipidemias-observed-HIV Infections', 'Neurotoxicity Syndromes-reduce-Neuroblastoma', 'Pneumococcal Infections-licensed-Pneumonia', 'Pneumococcal Infections-address-Pneumonia', 'Xerostomia-associated-Cardiac Output, Low', 'Cardiac Output, Low-associated-Xerostomia', 'Angiodysplasia-distinguish-Hemorrhage', 'Hypertension-rescued-Sotos Syndrome', 'Infections-drive-Asthma', 'Central Nervous System Diseases-produce-Gliosis', 'Malnutrition-identified-Diabetes Mellitus', 'Chronic Pain-identified-Diabetes Mellitus', 'Chronic Pain-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-Chronic Pain', 'Jaw Neoplasms-alleviate-Inflammation', 'Alzheimer Disease-include-Diabetes Mellitus, Type 2', 'Insulin Resistance-link-Diabetes Mellitus, Type 2', 'Alzheimer Disease-link-Diabetes Mellitus, Type 2', 'Death-decrease-Arrhythmias, Cardiac', 'Dementia-reflect-Immunologic Deficiency Syndromes', 'Death-occur-Shock, Cardiogenic', 'Death-occur-Heart Rupture', 'Death-occur-Heart Arrest', 'Shock, Cardiogenic-occur-Myocardial Infarction', 'Heart Rupture-occur-Myocardial Infarction', 'Heart Arrest-occur-Myocardial Infarction', 'Carcinoma, Hepatocellular-achieve-Fibrosis', 'Brain Diseases-contribute-Neurodegenerative Diseases', 'Sarcoma-mimic-Fasciitis', 'Fasciitis-mimic-Neoplasms', 'Low Back Pain-manage-Diabetes Mellitus', 'Nephrotic Syndrome-selected-Infections', 'Hypesthesia-aid-Sleep Wake Disorders', 'Spinocerebellar Ataxias-associated-Hepatitis, Viral, Human', 'Hepatitis, Viral, Human-associated-Spinocerebellar Ataxias', 'Spinocerebellar Ataxias-associated-Hepatitis, Autoimmune', 'Hepatitis, Autoimmune-associated-Spinocerebellar Ataxias', 'Spinocerebellar Ataxias-associated-Carcinoma, Hepatocellular', 'Carcinoma, Hepatocellular-associated-Spinocerebellar Ataxias', 'Dry Eye Syndromes-become-Anophthalmos', 'Pain-caused-Hyperkeratosis, Epidermolytic', 'Prostatic Neoplasms-assess-Neoplasms', 'Delirium-determined-Dementia', 'Metabolic Syndrome-consist-Chronic Disease', 'Metabolic Syndrome-predispose-Chronic Disease', 'Cardiovascular Diseases-make-Death', 'Brain Injuries, Traumatic-include-Brain Injuries', 'Cerebral Infarction-include-Brain Injuries', 'Cerebral Hemorrhage-include-Brain Injuries', 'Polycystic Ovary Syndrome-identified-Oligomenorrhea', 'Subarachnoid Hemorrhage-include-Brain Injuries', 'Polycystic Ovary Syndrome-identified-Hirsutism', 'Polycystic Ovary Syndrome-identified-Infertility, Female', 'Polycystic Ovary Syndrome-present-Infertility, Female', 'Oligomenorrhea-present-Infertility, Female', 'Hirsutism-present-Infertility, Female', 'Liver Diseases-induce-Chemical and Drug Induced Liver Injury', 'Skin Diseases-decrease-Keratosis, Actinic', 'Diabetes Mellitus, Type 2-administered-Cardiovascular Diseases', 'Thrombosis-prevent-Deglutition Disorders', 'Movement Disorders-score-Blepharospasm', 'Movement Disorders-blinded-Blepharospasm', 'Periodontitis-include-Communicable Diseases', 'Adrenal Insufficiency-ratesremain-Obesity', 'Ovarian Neoplasms-involve-Neoplasms', 'Ischemia-reduce-Myocardial Reperfusion Injury', 'Angina, Unstable-associated-Myocardial Infarction', 'Myocardial Infarction-associated-Angina, Unstable', 'Chest Pain-associated-Myocardial Infarction', 'Myocardial Infarction-associated-Chest Pain', 'Dementia-reduce-Atrial Fibrillation', 'Stroke-initiate-Ischemia', 'Heart Diseases-accounted-Death', 'Stroke-related-Death', 'Shock, Cardiogenic-derive-Death', 'Arteriovenous Malformations-result-Cerebral Infarction', 'Arteriovenous Malformations-result-Pericardial Effusion', 'Telangiectasia, Hereditary Hemorrhagic-associated-Hemorrhage', 'Hemorrhage-associated-Telangiectasia, Hereditary Hemorrhagic', 'Neoplasms-diagnosed-Death', 'Cardiac Output, Low-fall-Ulcer', 'Burkitt Lymphoma-include-Lymphoproliferative Disorders', 'Lymphomatoid Granulomatosis-include-Lymphoproliferative Disorders', 'Lymphoma, B-Cell-include-Lymphoproliferative Disorders', 'Lymphoproliferative Disorders-resemble-Lymphomatoid Papulosis', 'Parkinson Disease, Secondary-measured-Atrophy', 'Lymphoma-resemble-Lymphomatoid Papulosis', 'Lymphoma-resemble-Ulcer', 'Parkinson Disease-predict-Atrophy', 'Ossification of Posterior Longitudinal Ligament-relate-Alzheimer Disease', 'Death-admitted-Catastrophic Illness', 'Parkinson Disease-cause-Death', 'Memory Disorders-diagnosed-Dementia', 'Death-derive-Parkinson Disease', 'Diabetes Mellitus-result-Glaucoma', 'Cardiovascular Diseases-include-Stroke', 'Osteoarthritis-share-Obesity', 'Diabetes Mellitus-indicate-Cartilage Diseases', 'Alzheimer Disease-identify-Dementia', 'Dementia-progress-Pain', 'Acute Kidney Injury-manifest-Proteinuria', 'Nephritis, Interstitial-manifest-Proteinuria', 'Dementia-reported-Pain', 'HIV Infections-attributed-Acquired Immunodeficiency Syndrome', 'Infections-secrete-Neurotoxicity Syndromes', 'Acquired Immunodeficiency Syndrome-attributed-AIDS Arteritis, Central Nervous System', 'Acquired Immunodeficiency Syndrome-attributed-Infections', 'Dementia-driven-Stroke', 'Dementia-driven-Parkinson Disease, Secondary', 'Metabolic Syndrome-highlight-Obesity, Abdominal', 'Osteoporotic Fractures-inhibit-Osteoporosis', 'Sleep Wake Disorders-result-Hypoxia', 'Airway Obstruction-result-Hypoxia', 'Airway Obstruction-characterized-Hypoxia', 'Lymphohistiocytosis, Hemophagocytic-associated-Death', 'Death-associated-Lymphohistiocytosis, Hemophagocytic', 'Lymphohistiocytosis, Hemophagocytic-occur-Inflammation', 'Lymphohistiocytosis, Hemophagocytic-triggered-Infections', 'Lymphohistiocytosis, Hemophagocytic-triggered-Neoplasms', 'Inflammation-triggered-Infections', 'Inflammation-triggered-Neoplasms', 'Shock-diagnosed-Lymphohistiocytosis, Hemophagocytic', 'End Stage Liver Disease-seen-Hemophilia A', 'Hemophilia A-performed-Hemophilia B', 'Hepatitis C-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-Hepatitis C', 'Hepatitis C-associated-End Stage Liver Disease', 'End Stage Liver Disease-associated-Hepatitis C', 'Diabetes Mellitus-associated-End Stage Liver Disease', 'End Stage Liver Disease-associated-Diabetes Mellitus', 'Hepatitis C-prevent-End Stage Liver Disease', 'Atrophy-rate-Alzheimer Disease', 'Atrophy-rate-Dementia', 'Atrophy-rate-Lewy Body Disease', 'Vascular Calcification-stratified-Diabetes Mellitus', 'Diabetes Mellitus-associate-Vascular Calcification', 'Vascular Calcification-associate-Diabetes Mellitus', 'Vascular Calcification-associate-Nervous System Diseases', 'Nervous System Diseases-associate-Vascular Calcification', 'Vascular Calcification-associate-Retinal Diseases', 'Retinal Diseases-associate-Vascular Calcification', 'Vascular Calcification-associate-Diabetic Nephropathies', 'Diabetic Nephropathies-associate-Vascular Calcification', 'Neoplasms-evaluate-Death', 'Hemorrhage-increased-Drug-Related Side Effects and Adverse Reactions', 'Thrombosis-increased-Drug-Related Side Effects and Adverse Reactions', 'Infections-increased-Drug-Related Side Effects and Adverse Reactions', 'Thrombosis-become-Drug-Related Side Effects and Adverse Reactions', 'Zika Virus Infection-include-Microcephaly', 'Zika Virus Infection-include-Lissencephaly', 'Zika Virus Infection-include-Hydrocephalus', 'Zika Virus Infection-include-Arthrogryposis', 'Hydrocephalus-obtained-Abnormalities, Drug-Induced', 'Stroke-result-Heredodegenerative Disorders, Nervous System', 'Nervous System Diseases-include-Aphasia', 'Nervous System Diseases-less-Aphasia', 'Nervous System Diseases-include-Ataxia', 'Nervous System Diseases-less-Ataxia', 'Nervous System Diseases-include-Paresis', 'Nervous System Diseases-less-Paresis', 'Nervous System Diseases-include-Hearing Loss', 'Nervous System Diseases-less-Hearing Loss', 'Cough-identify-Pulmonary Disease, Chronic Obstructive', 'Cough-identify-Heart Failure', 'Cough-record-Pulmonary Disease, Chronic Obstructive', 'Cough-record-Heart Failure', 'HIV Infections-classified-Acquired Immunodeficiency Syndrome', 'Infections-classified-HIV Infections', 'Infections-classified-Acquired Immunodeficiency Syndrome', 'Acquired Immunodeficiency Syndrome-increase-Infections', 'Drug-Related Side Effects and Adverse Reactions-considered-Neoplasms', 'Wounds and Injuries-enter-Protein-Energy Malnutrition', 'Pulmonary Disease, Chronic Obstructive-live-HIV Infections', 'Pulmonary Disease, Chronic Obstructive-viewed-Lung Diseases', 'Pulmonary Disease, Chronic Obstructive-viewed-HIV Infections', 'Airway Obstruction-manifest-Lung Diseases', 'Airway Obstruction-manifest-Signs and Symptoms, Respiratory', 'Lung Diseases-manifest-Signs and Symptoms, Respiratory', 'HIV Infections-characterized-Lung Diseases', 'Anemia, Aplastic-associated-Death', 'Death-associated-Anemia, Aplastic', 'Hereditary Breast and Ovarian Cancer Syndrome-accumulate-Trauma, Nervous System', 'Peritoneal Neoplasms-present-Fever', 'Peritoneal Neoplasms-experience-Fever', 'Colorectal Neoplasms-increase-Genetic Diseases, Inborn', 'Colorectal Neoplasms-increase-Inflammation', 'Dementia-distributed-Alzheimer Disease', 'Fatigue-observed-Parkinson Disease', 'Sleep Wake Disorders-observed-Parkinson Disease', 'Diabetes Mellitus-classified-Cardiovascular Diseases', 'Immunologic Deficiency Syndromes-exacerbate-Parkinson Disease, Secondary', 'Immunologic Deficiency Syndromes-exacerbate-Alzheimer Disease', 'Stroke-lead-Death', 'Giant Cell Arteritis-present-Neoplasms', 'Polymyalgia Rheumatica-present-Myalgia', 'Polymyalgia Rheumatica-present-Arthralgia', 'Exanthema-associate-Death', 'Death-associate-Exanthema', 'Death-assess-Myocardial Infarction', 'Death-hospitalise-Myocardial Infarction', 'Immunologic Deficiency Syndromes-cause-Death', 'Inflammation-consist-Myocardial Infarction', 'Fibrosis-consist-Myocardial Infarction', 'Dementia-live-Neurodegenerative Diseases', 'Spinal Injuries-lead-Muscular Diseases', 'Death-encompass-Obesity', 'Diabetes Mellitus-improved-Hypertension', 'Diabetes Mellitus-improved-Hyperuricemia', 'Diabetes Mellitus-improved-Coronary Artery Disease', 'Sleep Apnea Syndromes-improved-Hyperuricemia', 'Hypertension-improved-Hyperuricemia', 'Hyperlipidemias-improved-Hyperuricemia', 'Death-calculate-Malocclusion', 'Death-include-Mesothelioma', 'Malocclusion-include-Mesothelioma', 'Death-rely-Pleural Neoplasms', 'Mesothelioma-rely-Pleural Neoplasms', 'Dementia-destined-Aneurysm', 'Lung Diseases-predispose-Respiratory Tract Infections', 'Thromboembolism-remain-Hemorrhage', 'Protein-Losing Enteropathies-result-Lymphoma', 'Infections-control-Bacteremia', 'Bacteremia-control-Coinfection', 'Bone Diseases, Metabolic-got-Osteoporosis', 'Drug-Related Side Effects and Adverse Reactions-focus-Neoplasms', 'Glioblastoma-recognized-Brain Neoplasms', 'Coronary Artery Disease-assessed-Vascular Calcification', 'Prostatic Neoplasms-demonstrate-Neoplasms', 'Myocarditis-include-Death', 'Heart Rupture-include-Death', 'Bundle-Branch Block-diagnose-Coronary Artery Disease', 'Bundle-Branch Block-suffer-Death', 'Diverticulitis-treated-Diabetes Mellitus', 'Osteoporosis-show-Death', 'Heart Failure-include-Ventricular Dysfunction', 'Congenital Abnormalities-include-Ventricular Dysfunction', 'Shock, Septic-define-Sepsis', 'Death-estimated-Inflammation', 'Drug Eruptions-consist-Erythema Nodosum', 'Alzheimer Disease-result-Mitochondrial Diseases', 'Headache Disorders, Secondary-slow-Atherosclerosis', 'Headache Disorders, Secondary-prevent-Venous Thrombosis', 'Atherosclerosis-prevent-Venous Thrombosis', 'Osteoarthritis-suffer-Pain', 'Neoplasms-include-von Willebrand Diseases', 'Hypothyroidism-include-von Willebrand Diseases', 'Cardiovascular Diseases-include-von Willebrand Diseases', 'Hemorrhage-exist-Venous Thrombosis', 'Hemorrhage-prevent-Neoplasms', 'Headache Disorders, Secondary-predispose-Dementia', 'Lymphohistiocytosis, Hemophagocytic-exclude-Neoplasms', 'Alzheimer Disease-affect-Weight Loss', 'Alzheimer Disease-affect-Memory Disorders', 'Alzheimer Disease-cause-Weight Loss', 'Werner Syndrome-use-Hypoxia', 'Werner Syndrome-remain-Drug Hypersensitivity', 'Primary Ovarian Insufficiency-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-Primary Ovarian Insufficiency', 'Hodgkin Disease-develop-Primary Ovarian Insufficiency', 'Airway Obstruction-predict-Pulmonary Disease, Chronic Obstructive', 'Pulmonary Disease, Chronic Obstructive-associated-Chronic Disease', 'Chronic Disease-associated-Pulmonary Disease, Chronic Obstructive', 'Prostatic Neoplasms-become-Breast Neoplasms, Male', 'Neoplasms-turned-Chronic Disease', 'Neoplasms-live-Arthritis, Rheumatoid', 'Chronic Disease-live-Neoplasms', 'Chronic Disease-live-Arthritis, Rheumatoid', 'Prostatic Neoplasms-contextualize-Death', 'Cardiovascular Diseases-given-Death', 'Constriction, Pathologic-investigate-Pain', 'Neck Pain-predict-Uterine Cervicitis', 'Sarcopenia-assessed-Parkinson Disease', 'Sarcopenia-associated-Parkinson Disease', 'Parkinson Disease-associated-Sarcopenia', 'Pain-associated-Parkinson Disease', 'Parkinson Disease-associated-Pain', 'Parkinson Disease-experience-Pain', 'Osteoarthritis-reveal-Scoliosis', 'Osteoarthritis-reveal-Parkinson Disease', 'Osteoarthritis-reveal-Low Back Pain', 'Communicable Diseases-used-Diabetes Mellitus', 'Dementia-treat-Hip Fractures', 'Death-compared-Dementia', 'Death-treat-Hip Fractures', 'Microvascular Angina-associated-Stroke, Lacunar', 'Stroke, Lacunar-associated-Microvascular Angina', 'Microvascular Angina-associated-Leukoaraiosis', 'Leukoaraiosis-associated-Microvascular Angina', 'Microvascular Angina-associated-Dementia, Vascular', 'Dementia, Vascular-associated-Microvascular Angina', 'Microvascular Angina-increase-Alzheimer Disease', 'Neurodegenerative Diseases-influence-Parkinson Disease', 'Multiple Sclerosis-include-Olfaction Disorders', 'Neuromyelitis Optica-include-Olfaction Disorders', 'Lupus Erythematosus, Systemic-include-Olfaction Disorders', 'Inflammation-include-Olfaction Disorders', 'Neuromyelitis Optica-include-Autoimmune Diseases', 'Inflammation-include-Autoimmune Diseases', 'Headache Disorders, Primary-provide-Cardiac Output, Low', 'Cardiac Output, Low-fall-Headache Disorders, Primary', 'Infections-include-Meningitis', 'Infections-cause-Meningitis', 'Meningitis-followed-Vestibular Diseases', 'Deafness-followed-Vestibular Diseases', 'Diplopia-seen-Optic Nerve Diseases', 'Cranial Nerve Diseases-seen-Optic Nerve Diseases', 'Death-occur-Intracranial Hemorrhages', 'Alzheimer Disease-drive-Neurologic Manifestations', 'Heart Failure-diagnosed-Death', 'Death-diagnosed-Kidney Diseases', 'Xerostomia-become-Deglutition Disorders', 'Blindness-characterized-Neurodegenerative Diseases', 'Breast Neoplasms-seek-Neoplasms', 'Breast Neoplasms-seek-Carcinoma, Lobular', 'Breast Neoplasms-seek-Neoplasm Invasiveness', 'Neoplasms-seek-Neoplasm Invasiveness', 'Carcinoma, Lobular-seek-Neoplasm Invasiveness', 'Brain Injuries, Traumatic-related-Wounds and Injuries', 'Deafness-remain-Hearing Loss', 'Lymphoma, T-Cell-manifest-Bone Marrow Failure Disorders', 'Lymphoma, T-Cell-cause-Opportunistic Infections', 'Bone Marrow Failure Disorders-cause-Opportunistic Infections', 'Metabolic Syndrome-become-Polycystic Ovary Syndrome', 'Coronary Artery Disease-suffer-Adrenal Insufficiency', 'Psoriasis-remain-Arthritis, Psoriatic', 'Sleep Apnea Syndromes-reveal-Sleepiness', 'Sleep Initiation and Maintenance Disorders-reveal-Sleepiness', 'Drug-Related Side Effects and Adverse Reactions-exploited-Neoplasms', 'Mitral Valve Insufficiency-result-Death', 'Colitis, Ulcerative-misdiagnosed-IgA Vasculitis', 'Spinal Fractures-identified-Fractures, Bone', 'Dementia-increase-Stomatognathic Diseases', 'Chronic Disease-compared-Dementia', 'Dementia-predict-Hip Fractures', 'Dementia-predict-Fractures, Bone', 'Neoplasms-develop-Leukemia', 'Leukemia, Myeloid, Acute-develop-Leukemia', 'Death-reflect-Inflammation', 'Tricuspid Valve Insufficiency-become-Death', 'Heart Valve Diseases-become-Death', 'Fractures, Bone-remain-Anemia', 'Fractures, Bone-prevent-Coronary Artery Disease', 'Infections-cause-Nervous System Diseases', 'HIV Infections-accelerate-Infections', 'Myopia-include-Anophthalmos', 'Pancreatitis-evaluated-Death', 'Diabetes Mellitus-know-Renal Tubular Transport, Inborn Errors', 'Pupil Disorders-indicate-Optic Nerve Diseases', 'Scotoma-indicate-Optic Nerve Diseases', 'Diabetes Mellitus-include-Diabetes Mellitus, Type 2', 'Polycystic Ovary Syndrome-linked-Metabolic Diseases', 'Polycystic Ovary Syndrome-demonstrate-Atherosclerosis', 'Polycystic Ovary Syndrome-persist-Metabolic Diseases', 'Hypertension, Pulmonary-devastate-Heart Failure', 'Hypertension, Pulmonary-devastate-Death', 'Pulmonary Arterial Hypertension-delayed-Coronary Artery Disease', 'Atrial Fibrillation-include-Hypothyroidism', 'Pulmonary Arterial Hypertension-delayed-Multiple Chronic Conditions', 'Kidney Diseases-include-Hypothyroidism', 'Death-seen-Pulmonary Disease, Chronic Obstructive', 'Acute Coronary Syndrome-evaluate-Death', 'Acute Coronary Syndrome-evaluate-Stroke', 'Acute Coronary Syndrome-evaluate-Coronary Artery Disease', 'Chest Pain-fall-Stroke', 'Atrophy-observed-Alzheimer Disease', 'Atrophy-seen-Alzheimer Disease', 'Atrophy-contribute-Alzheimer Disease', 'Parkinson Disease, Secondary-avoid-Death', 'Alzheimer Disease-assessed-Obesity', 'Alzheimer Disease-assessed-Hypertension', 'Alzheimer Disease-assessed-Diabetes Mellitus', 'Alzheimer Disease-assessed-Craniocerebral Trauma', 'Alzheimer Disease-assessed-Infections', 'Atherosclerosis-include-Hyperlipidemias', 'TDP-43 Proteinopathies-include-Amyotrophic Lateral Sclerosis', 'Nerve Degeneration-include-Amyotrophic Lateral Sclerosis', 'Amyotrophic Lateral Sclerosis-lead-Neurodegenerative Diseases', 'Gout-represent-Arthritis', 'Hypogonadism-include-Erectile Dysfunction', 'Hypogonadism-include-Bone Diseases, Metabolic', 'Hypogonadism-include-Osteoporosis', 'Hypothalamic Neoplasms-classified-Hypogonadism', 'Neoplasms-include-Kidney Diseases', 'Vasculitis-include-Giant Cell Arteritis', 'Parkinson Disease-involve-Sleep Wake Disorders', 'Parkinson Disease-involve-Gastrointestinal Diseases', 'Renal Insufficiency, Chronic-characterised-Nephritis, Interstitial', 'Renal Insufficiency, Chronic-characterised-Fibrosis', 'Glucose Metabolism Disorders-observed-Alzheimer Disease', 'Langerhans Cell Sarcoma-represented-Inflammation', 'Infections-involved-Inflammation', 'Mitochondrial Diseases-involve-Brain Diseases, Metabolic', 'Mitochondrial Diseases-result-Death', 'Psoriasis-obtained-Angina Pectoris', 'Psoriasis-obtained-Stroke', 'Myocardial Infarction-obtained-Angina Pectoris', 'Alzheimer Disease-empower-Dementia', 'Sarcopenia-refer-Muscular Diseases', 'Muscular Diseases-refer-Neuromuscular Diseases', 'Amyloidosis-develop-Inflammation', 'Muscular Diseases-refer-Death', 'Heart Failure-threatening-Ventricular Fibrillation', 'Aneuploidy-cause-Infertility, Female', 'Postoperative Cognitive Complications-find-Death', 'Asthma-include-Neurodegenerative Diseases', 'Colorectal Neoplasms-resulted-Death', 'Prostatic Neoplasms-develop-Death', 'Osteoarthritis-suspected-Pain', 'Dementia-associate-Neurodegenerative Diseases', 'Neurodegenerative Diseases-associate-Dementia', 'Cardiotoxicity-detect-Heart Diseases', 'Cardiotoxicity-modify-Neoplasms', 'Heart Diseases-modify-Neoplasms', 'Medulloblastoma-include-Neoplasms', 'Neoplasms-exposed-Cardiovascular Diseases', 'Cardiovascular Diseases-develop-Neoplasms', 'Neoplasms-used-Ischemia', 'Death-cause-Heart Diseases', 'Death-cause-Cerebrovascular Disorders', 'Death-cause-Kidney Diseases', 'Neoplasms-relate-Inflammation', 'Neoplasms-implement-Death', 'Neoplasms-implement-Parkinson Disease', 'Neoplasms-enhance-Death', 'Neurodegenerative Diseases-focus-Parkinson Disease', 'Neurodegenerative Diseases-focus-Huntington Disease', 'Infections-include-Bone Diseases, Metabolic', 'Mandibular Nerve Injuries-include-Bone Diseases, Metabolic', 'Alzheimer Disease-worsen-Neurodegenerative Diseases', 'Neoplasms-diagnosed-Acute Coronary Syndrome', 'Sleep Apnea, Obstructive-recommended-Weight Loss', 'Sleep Apnea, Obstructive-classified-Obesity', 'Neuroblastoma-use-Drug-Related Side Effects and Adverse Reactions', 'Carcinogenesis-activate-Obesity', 'Death-become-HIV Infections', 'Headache-include-Pneumonia', 'Nausea-include-Pneumonia', 'Pneumonia-include-Abdominal Pain', 'Postoperative Complications-occur-Hip Fractures', 'Neoplasms-associated-Pneumonia', 'Pneumonia-associated-Neoplasms', 'Stroke-identified-Pneumonia', 'Neoplasms-identified-Pneumonia', 'Thrombocytopenia-identified-Pneumonia', 'Hyperglycemia-identified-Pneumonia', 'Mitochondrial Diseases-implicated-Muscular Dystrophies', 'Mitochondrial Diseases-implicated-Atrophy', 'Mitochondrial Diseases-implicated-Sarcopenia', 'Death-encompass-Parkinson Disease', 'Parkinson Disease-pass-Drug-Related Side Effects and Adverse Reactions', 'Obesity-predispose-Atherosclerosis', 'Diabetes Mellitus, Type 2-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-Diabetes Mellitus, Type 2', 'Diabetes Mellitus, Type 2-associated-Cerebral Small Vessel Diseases', 'Cerebral Small Vessel Diseases-associated-Diabetes Mellitus, Type 2', 'Dyskeratosis Congenita-known-Macular Degeneration', 'Dyskeratosis Congenita-known-Leukoplakia', 'Dyskeratosis Congenita-known-Hyperpigmentation', 'Genetic Diseases, Inborn-known-Macular Degeneration', 'Genetic Diseases, Inborn-known-Leukoplakia', 'Genetic Diseases, Inborn-known-Hyperpigmentation', 'Bone Marrow Failure Disorders-account-Death', 'Cerebral Palsy-known-Mercury Poisoning, Nervous System', 'Kidney Failure, Chronic-reduce-Proteinuria', 'Death-associated-Myopia', 'Myopia-associated-Death', 'Death-predict-Brain Injuries, Traumatic', 'Fatty Liver-associated-Myotonic Dystrophy', 'Myotonic Dystrophy-associated-Fatty Liver', 'Diabetes Mellitus, Type 2-associated-Pancreatic Neoplasms', 'Pancreatic Neoplasms-associated-Diabetes Mellitus, Type 2', 'Fatty Liver-associated-Pancreatic Neoplasms', 'Pancreatic Neoplasms-associated-Fatty Liver', 'Hypertension-predict-Kidney Diseases', 'Hyperkalemia-predict-Kidney Diseases', 'Esotropia-follows-Exotropia', 'Orbital Diseases-follows-Exotropia', 'Cranial Nerve Diseases-follows-Exotropia', 'Diplopia-caused-Orbital Diseases', 'Orbital Diseases-exhibit-Esotropia', 'Esotropia-do-Cranial Nerve Diseases', 'Esotropia-do-Chronic Disease', 'Retinal Degeneration-contribute-Hearing Loss', 'Nervous System Diseases-use-Ear Diseases', 'Sleep Wake Disorders-alleviate-Headache Disorders, Secondary', 'Sarcopenia-differentiated-Cachexia', 'Sarcopenia-differentiated-Weight Loss', 'Sarcopenia-characterized-Weight Loss', 'Sarcopenia-differentiated-Anorexia', 'Sarcopenia-characterized-Anorexia', 'Cachexia-characterized-Weight Loss', 'Cachexia-characterized-Anorexia', 'Sarcopenia-exact-Metabolic Diseases', 'Sarcopenia-exact-Death', 'Sarcopenia-include-Metabolic Syndrome', 'Vision Disorders-establish-Dementia', 'Sarcopenia-known-Obesity', 'Liver Neoplasms-mimic-Carcinoma, Hepatocellular', 'Neoplasms-expressed-Chemical and Drug Induced Liver Injury', 'Nerve Degeneration-resemble-Alzheimer Disease', 'Coinfection-exacerbated-Cardiac Output, Low', 'Renal Insufficiency, Chronic-lead-Multiple Organ Failure', 'Diabetes Mellitus-lead-Multiple Organ Failure', 'Cardiovascular Diseases-lead-Multiple Organ Failure', 'Neoplasms-diagnosed-Carcinoma, Squamous Cell', 'Multiple Organ Failure-increase-Neoplasms', 'Corneal Diseases-collected-Hypertension', 'Corneal Diseases-collected-Diabetes Mellitus', 'Death-cause-Hypertension', 'Myocardial Infarction-cause-Hypertension', 'Cough-present-Hypoxia', 'Cough-present-Pneumonia', 'Pneumonia, Pneumocystis-known-Pneumocystis Infections', 'Hypoxia-present-Pneumonia', 'Infections-infect-HIV Infections', 'Ovarian Diseases-associated-Bone Neoplasms', 'Bone Neoplasms-associated-Ovarian Diseases', 'Death-synchronize-Movement Disorders', 'Myelodysplastic Syndromes-characterized-Hypotension', 'Vision Disorders-identify-Hearing Loss', 'Epilepsy-misdiagnosed-Dementia', 'Memory Disorders-misdiagnosed-Epilepsy', 'Memory Disorders-misdiagnosed-Dementia', 'Seizures-needed-Epilepsy', 'Neoplasms-occur-Anemia, Aplastic', 'Anemia, Aplastic-occur-Leukemia, Myeloid, Acute', 'Leukemia-associated-Hematologic Neoplasms', 'Hematologic Neoplasms-associated-Leukemia', 'Cardiovascular Diseases-support-Inflammation', 'Atrophy-reflect-Brain Diseases', 'Atrophy-reflect-Alzheimer Disease', 'Prostatic Neoplasms-considered-Neoplasms', 'Dyslipidemias-associated-Neoplasms', 'Neoplasms-associated-Dyslipidemias', 'Alzheimer Disease-include-Atrophy', 'Coronary Artery Disease-play-Inflammation', 'Disease-play-Inflammation', 'Cerebral Infarction-defined-Stroke', 'Renal Insufficiency, Chronic-develop-Kidney Failure, Chronic', 'Hematuria-associated-Renal Insufficiency', 'Renal Insufficiency-associated-Hematuria', 'Proteinuria-associated-Renal Insufficiency', 'Renal Insufficiency-associated-Proteinuria', 'Acute Kidney Injury-associated-Renal Insufficiency', 'Renal Insufficiency-associated-Acute Kidney Injury', 'Inflammation-investigate-Neurodegenerative Diseases', 'Cardiovascular Diseases-impose-Death', 'Inflammation-linked-Death', 'Inflammation-linked-Sarcopenia', 'Dementia-explained-Communicable Diseases', 'Hip Fractures-associated-Chronic Pain', 'Chronic Pain-associated-Hip Fractures', 'Hemolytic-Uremic Syndrome-remain-Cardiovascular Diseases', 'Heart Failure-related-Death', 'Heart Failure-conducted-Death', 'Malnutrition-associated-Pain', 'Pain-associated-Malnutrition', 'Genetic Diseases, Inborn-manifested-Xeroderma Pigmentosum', 'Genetic Diseases, Inborn-manifested-Cockayne Syndrome', 'Genetic Diseases, Inborn-manifested-Trichothiodystrophy Syndromes', 'Edema-protect-Neoplasms', 'Renal Insufficiency, Chronic-affect-Inflammation', 'Diabetes Mellitus-affect-Inflammation', 'Neoplasms-affect-Inflammation', 'Dementia-affect-Inflammation', 'Sarcopenia-affect-Inflammation', 'Inflammation-affect-Cardiovascular Diseases', 'Pneumonia-related-Tuberculosis, Meningeal', 'Sepsis-related-Tuberculosis, Meningeal', 'Death-include-Substance-Related Disorders', 'Death-notified-Substance-Related Disorders', 'Death-notified-Neoplasms', 'Death-include-Lung Neoplasms', 'Death-notified-Lung Neoplasms', 'Substance-Related Disorders-live-Neoplasms', 'Neoplasms-live-Lung Neoplasms', 'Brain Injuries, Traumatic-related-Coma', 'Urogenital Abnormalities-underestimated-Pain Insensitivity, Congenital', 'Urologic Diseases-reported-Pain Insensitivity, Congenital', 'Urinary Bladder, Neurogenic-reported-Pain Insensitivity, Congenital', 'Erectile Dysfunction-reported-Pain Insensitivity, Congenital', 'Sexual Dysfunction, Physiological-reported-Pain Insensitivity, Congenital', 'Infections-involve-Death', 'Alstrom Syndrome-include-Disease', 'Postpartum Hemorrhage-decrease-Postoperative Complications', 'Sarcopenia-prevent-Muscle Weakness', 'Infections-benefit-Seizures', 'Venous Insufficiency-diagnose-Heart Valve Diseases', 'Disease-caused-Heart Valve Diseases', 'Erectile Dysfunction-treat-Adrenal Insufficiency', 'Erectile Dysfunction-cost-Death', 'Erectile Dysfunction-prevent-Death', 'Pain-use-Knee Injuries', 'Death-result-Fibrosis', 'Metabolic Diseases-cause-Fibrosis', 'Metabolic Diseases-cause-Infarction', 'Fibrosis-cause-Infarction', 'Fibrosis-driven-Cardiomyopathies', 'Fibrosis-target-Cardiomyopathies', 'Heart Arrest-linked-Lipodystrophy', 'Heart Arrest-linked-Osteoporosis', 'Infections-driven-Death', 'Infections-experience-Death', 'Immunologic Deficiency Syndromes-explain-Delirium', 'Sleep Deprivation-explain-Delirium', 'Hypoxia-explain-Delirium', 'Liver Failure-associated-Chemical and Drug Induced Liver Injury', 'Chemical and Drug Induced Liver Injury-associated-Liver Failure', 'Infections-cause-Cold Injury', 'Infections-linked-Inflammation', 'Osteoporosis-associated-Multiple Myeloma', 'Multiple Myeloma-associated-Osteoporosis', 'Osteoporosis-develop-Multiple Myeloma', 'Parkinson Disease-show-REM Sleep Behavior Disorder', 'REM Sleep Behavior Disorder-represent-Synucleinopathies', 'REM Sleep Behavior Disorder-represent-Parkinson Disease', 'Neurologic Manifestations-associated-REM Sleep Behavior Disorder', 'REM Sleep Behavior Disorder-associated-Neurologic Manifestations', 'REM Sleep Behavior Disorder-represent-Dementia', 'REM Sleep Behavior Disorder-represent-Shy-Drager Syndrome', 'Parkinson Disease-include-Parkinson Disease, Secondary', 'Delirium-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-Delirium', 'Delirium-associated-Postpartum Hemorrhage', 'Postpartum Hemorrhage-associated-Delirium', 'Delirium-associated-Coronary Artery Disease', 'Coronary Artery Disease-associated-Delirium', 'Delirium-associated-Cerebral Infarction', 'Cerebral Infarction-associated-Delirium', 'Sarcopenia-require-Atrophy', 'Death-offer-Sleep Initiation and Maintenance Disorders', 'Renal Insufficiency, Chronic-offer-Sleep Initiation and Maintenance Disorders', 'Albuminuria-identified-Dementia', 'Neurodegenerative Diseases-represent-Dementia', 'Seizures-related-Nerve Degeneration', 'Seizures-related-Alzheimer Disease', 'Seizures-related-Neurodegenerative Diseases', 'Nerve Degeneration-contribute-Seizures', 'Alzheimer Disease-contribute-Seizures', 'Neurodegenerative Diseases-contribute-Seizures', 'Alzheimer Disease-present-Neurodegenerative Diseases', 'Inflammation-present-Neurodegenerative Diseases', 'Glioblastoma-limit-Drug-Related Side Effects and Adverse Reactions', 'Renal Insufficiency, Chronic-increasing-Diabetes Mellitus', 'Renal Insufficiency, Chronic-increasing-Hypertension', 'Cerebrospinal Fluid Rhinorrhea-cause-Nervous System Diseases', 'Constriction, Pathologic-play-Nerve Degeneration', 'Obesity-associated-Non-alcoholic Fatty Liver Disease', 'Non-alcoholic Fatty Liver Disease-associated-Obesity', 'Death-caused-Cerebral Infarction', 'Ataxia-associated-Obesity', 'Obesity-associated-Ataxia', 'Hypertension-found-Carotid Artery Diseases', 'Diabetes Mellitus-found-Carotid Artery Diseases', 'Fractures, Bone-increase-Sarcopenia', 'Muscle Weakness-follow-Fatigue', 'Hyperthyroidism-associated-Arrhythmias, Cardiac', 'Arrhythmias, Cardiac-associated-Hyperthyroidism', 'Hyperthyroidism-cause-Hypothyroidism', 'Hyperthyroidism-cause-Atherosclerosis', 'Arrhythmias, Cardiac-cause-Hypothyroidism', 'Arrhythmias, Cardiac-cause-Atherosclerosis', 'Hypothyroidism-cause-Atherosclerosis', 'Myocardial Infarction-related-Heart Diseases', 'Heart Failure-related-Heart Diseases', 'Arrhythmias, Cardiac-related-Heart Diseases', 'Infections-documented-Endocarditis', 'HIV Infections-pass-Chronic Disease', 'Fibrosis-estimate-Liver Failure', 'Foodborne Diseases-occur-Infections', 'Congenital Abnormalities-associated-Neoplasms', 'Neoplasms-associated-Congenital Abnormalities', 'Congenital Abnormalities-associated-Neurodegenerative Diseases', 'Neurodegenerative Diseases-associated-Congenital Abnormalities', 'Lupus Erythematosus, Systemic-overlap-Myasthenia Gravis', 'Dysbiosis-trigger-Inflammation', 'Death-mean-Multiple Organ Failure', 'Death-mean-Neoplasms', 'HIV Infections-mean-Multiple Organ Failure', 'HIV Infections-mean-Neoplasms', 'Pain-measure-Osteoarthritis', 'Neoplasms-comprise-Death', 'Infections-comprise-Death', 'Neoplasms-differentiated-Carcinoma, Transitional Cell', 'Stroke-associated-Hyperlipidemias', 'Hyperlipidemias-associated-Stroke', 'Hypertension-impact-Leukoencephalopathies', 'Hyperlipidemias-include-Hypertension', 'Hyperlipidemias-include-Metabolic Syndrome', 'Obesity-co-exist-Chronic Disease', 'Chronic Disease-exists-Obesity', 'Chronic Disease-co-exist-Obesity', 'Obesity-lead-Death', 'Chronic Disease-up-regulate-Inflammation', 'Bone Marrow Diseases-found-Osteoarthritis', 'Brain Ischemia-lead-Nerve Degeneration', 'Brain Ischemia-lead-Death', 'Alzheimer Disease-provide-Retinal Degeneration', 'Diabetes Mellitus-develop-Eye Pain', 'Diabetes Mellitus-transferred-Ophthalmoplegia', 'Diabetes Mellitus-transferred-Sinus Thrombosis, Intracranial', 'Eye Pain-revealed-Sinus Thrombosis, Intracranial', 'Ophthalmoplegia-transferred-Sinus Thrombosis, Intracranial', 'Orbital Diseases-reveal-Mycoses', 'Diabetes Mellitus-hospitalized-Arrhythmias, Cardiac', 'Hypertension-improve-Diabetes Mellitus', 'Osteoarthritis-described-Inflammation', 'Ischemia-lead-Neurodegenerative Diseases', 'Ischemia-display-Dementia', 'Aneurysm-lead-Neurodegenerative Diseases', 'Aneurysm-lead-Atrophy', 'Cerebral Small Vessel Diseases-identified-Leukoencephalopathies', 'Atrophy-include-Cerebral Small Vessel Diseases', 'Brain Injuries-result-Death', 'Sarcopenia-termed-Death', 'Cockayne Syndrome-characterized-Atrophy', 'Genetic Diseases, Inborn-characterized-Atrophy', 'Death-compare-Colorectal Neoplasms', 'Dementia, Vascular-complicated-Psychoses, Substance-Induced', 'Hypertension-consider-Cushing Syndrome', 'Alkalosis-consider-Cushing Syndrome', 'Hirsutism-consider-Cushing Syndrome', 'Infections-consider-Cushing Syndrome', 'Autoimmune Diseases-treat-Dementia', 'Periapical Periodontitis-occur-Wounds and Injuries', 'Pain-associated-Memory Disorders', 'Memory Disorders-associated-Pain', 'Staphylococcal Infections-associated-Death', 'Death-associated-Staphylococcal Infections', "Sjogren's Syndrome-affect-Xerostomia", 'Osteomalacia-contribute-Fractures, Bone', 'Progeria-manifest-Fractures, Bone', 'Gout-assess-Cardiovascular Diseases', 'Mouth Diseases-burn-Pain', 'Hepatitis B-adjusted-Liver Diseases', 'Hepatitis-develop-Carcinoma, Hepatocellular', 'Hepatitis B-develop-Carcinoma, Hepatocellular', 'Carcinoma, Hepatocellular-cause-Liver Diseases', 'Hepatitis B-cause-Liver Diseases', 'Parkinson Disease-considered-Retinal Degeneration', 'Movement Disorders-considered-Retinal Degeneration', 'Cerebral Infarction-recognized-Aneurysm', 'Sleep Wake Disorders-pose-Cardiovascular Diseases', 'Sleep Wake Disorders-pose-Hypertension', 'Sleep Wake Disorders-pose-Stroke', 'Infections-develop-Tuberculosis', 'Cardiovascular Diseases-related-Obesity', 'Obesity-defined-Chronic Disease', 'Inflammation-prevent-Coinfection', 'Inflammation-prevent-Cerebral Hemorrhage', 'Leukemia, Myeloid, Acute-increase-Death', 'Double Outlet Right Ventricle-discriminate-Leukemia, Myeloid, Acute', 'Inflammation-cause-Stroke', 'AIDS Arteritis, Central Nervous System-reflect-HIV Infections', 'Ataxia-described-AIDS Arteritis, Central Nervous System', 'AIDS Arteritis, Central Nervous System-reflect-Inflammation', 'HIV Infections-reflect-Ataxia', 'Stroke-cause-Coronary Artery Disease', 'HIV Infections-reflect-AIDS Arteritis, Central Nervous System', 'Atherosclerosis-associated-Chronic Disease', 'Chronic Disease-associated-Atherosclerosis', 'Bone Diseases-include-Chronic Disease', 'Fibrosis-contribute-Heart Diseases', 'Alzheimer Disease-reflect-Wallerian Degeneration', 'Alzheimer Disease-fail-Neurodegenerative Diseases', 'Alzheimer Disease-incorporate-Neurodegenerative Diseases', 'Bone Neoplasms-increase-Osteoporosis', 'Obesity-remain-Kidney Failure, Chronic', 'Kidney Failure, Chronic-described-Obesity', 'Obesity-linked-Cachexia', 'Diabetes Mellitus-lead-Cachexia', 'Weight Loss-linked-Cardiomyopathies', 'Weight Loss-linked-Arrhythmias, Cardiac', 'Hypertension-lead-Cachexia', 'Weight Loss-linked-Death, Sudden', 'Cardiovascular Diseases-lead-Cachexia', 'Death-lead-Cachexia', 'Metabolic Syndrome-lead-Cachexia', 'Kidney Failure, Chronic-help-Obesity', 'Kidney Failure, Chronic-include-Renal Insufficiency, Chronic', 'Hypertension-focus-Death', 'Kidney Failure, Chronic-derived-Cachexia', 'Gallstones-impacted-Colonic Neoplasms', 'Brain Injuries, Traumatic-demonstrate-Neurologic Manifestations', 'Sepsis-approaches-Myocardial Infarction', 'Sepsis-exceed-Death', 'Sepsis-exceed-Stroke', 'Death-approaches-Myocardial Infarction', 'Death-exceed-Stroke', 'Myocardial Infarction-exceed-Death', 'Myocardial Infarction-exceed-Stroke', 'Sepsis-redefine-Iridocorneal Endothelial Syndrome', 'Sepsis-redefine-Disseminated Intravascular Coagulation', 'Sepsis-redefine-Infections', 'Sepsis-redefine-Multiple Organ Failure', 'Iridocorneal Endothelial Syndrome-redefine-Disseminated Intravascular Coagulation', 'Iridocorneal Endothelial Syndrome-redefine-Infections', 'Iridocorneal Endothelial Syndrome-redefine-Multiple Organ Failure', 'Sepsis-known-Purpura', 'Purpura-known-Hearing Loss', 'Purpura-known-Nervous System Diseases', 'Hepatitis B-cause-Carcinoma, Hepatocellular', 'Hepatitis B-associated-Neoplasms', 'Neoplasms-associated-Hepatitis B', 'Hepatitis B-associated-Carcinoma, Hepatocellular', 'Carcinoma, Hepatocellular-associated-Hepatitis B', 'Hepatitis B-associated-Bile Duct Neoplasms', 'Bile Duct Neoplasms-associated-Hepatitis B', 'Arteriolosclerosis-demonstrate-Leukoaraiosis', 'Osteoporosis-caused-Hyperparathyroidism', 'Shock-contribute-Demyelinating Diseases', 'Arteriovenous Fistula-created-Kidney Failure, Chronic', 'Arteriovenous Fistula-reveal-Heart Failure', 'Neurilemmoma-included-Gastrointestinal Stromal Tumors', 'Neurilemmoma-included-Endocrine System Diseases', 'Wounds and Injuries-associated-Pain', 'Pain-associated-Wounds and Injuries', 'Hypertension-taper-Neoplasms', 'Diabetes Mellitus-taper-Neoplasms', 'Chronic Disease-function-Pain', 'Neoplasms-provide-Acromegaly', 'Sleep Initiation and Maintenance Disorders-associated-Diabetes Mellitus, Type 2', 'Diabetes Mellitus, Type 2-associated-Sleep Initiation and Maintenance Disorders', 'Sleep Initiation and Maintenance Disorders-associated-Dyslipidemias', 'Dyslipidemias-associated-Sleep Initiation and Maintenance Disorders', 'Sleep Initiation and Maintenance Disorders-associated-Neoplasms', 'Neoplasms-associated-Sleep Initiation and Maintenance Disorders', 'Meningeal Neoplasms-affected-Neoplasms', 'Hyperuricemia-contribute-Osteoporotic Fractures', 'Inflammation-contribute-Osteoporotic Fractures', 'Hip Fractures-include-Cardiovascular Diseases', 'Pulmonary Disease, Chronic Obstructive-include-Cardiovascular Diseases', 'Pneumonia-include-Cardiovascular Diseases', 'Intellectual Disability-include-HIV Infections', 'Microcephaly-include-HIV Infections', 'Neurodegenerative Diseases-include-HIV Infections', 'Dementia-taken-Heredodegenerative Disorders, Nervous System', 'Parkinson Disease-appreciated-Mitochondrial Diseases', 'Osteoporotic Fractures-associated-Pain', 'Pain-associated-Osteoporotic Fractures', 'Osteoporotic Fractures-associated-Hip Fractures', 'Hip Fractures-associated-Osteoporotic Fractures', 'Hip Fractures-associated-Pain', 'Pain-associated-Hip Fractures', 'Osteoporosis-screen-Osteoporotic Fractures', 'Genetic Diseases, Inborn-lead-Neurodegenerative Diseases', 'Infections-cause-Pulmonary Disease, Chronic Obstructive', 'Death-appear-Pulmonary Disease, Chronic Obstructive', 'Obesity-potentiate-Hypertension', 'Obesity-potentiate-Hypertrophy, Left Ventricular', 'Fibrosis-reduce-Heart Failure', 'Vascular Calcification-linked-Cerebral Small Vessel Diseases', 'Tinnitus-associated-Dementia', 'Dementia-associated-Tinnitus', 'Sarcopenia-describe-Muscle Weakness', 'Neurodegenerative Diseases-include-Neoplasms', 'Uterine Cervicitis-experience-Fractures, Bone', 'Fractures, Bone-compare-Dementia', 'Fractures, Bone-compare-Cerebrovascular Disorders', 'Fractures, Bone-experience-Uterine Cervicitis', 'Uterine Cervicitis-associated-Fractures, Bone', 'Fractures, Bone-associated-Uterine Cervicitis', 'Cardiovascular Diseases-support-Diabetes Mellitus, Type 2', 'Cardiovascular Diseases-discussed-Peripheral Arterial Disease', 'Peripheral Arterial Disease-compare-Cerebrovascular Disorders', 'Venous Thrombosis-associated-Hemorrhage', 'Hemorrhage-associated-Venous Thrombosis', 'Pulmonary Embolism-associated-Hemorrhage', 'Hemorrhage-associated-Pulmonary Embolism', 'Embolism-associated-Hemorrhage', 'Hemorrhage-associated-Embolism', 'Peripheral Arterial Disease-related-Death', 'Peripheral Arterial Disease-related-Ischemia', 'Pain Insensitivity, Congenital-represent-Diabetes Mellitus', 'Diabetes Mellitus-cause-Retinal Detachment', 'Peripheral Nervous System Diseases-increase-Diabetes Mellitus', 'Retinal Diseases-increase-Diabetes Mellitus', 'Mitochondrial Diseases-investigated-Neoplasms', 'Mitochondrial Diseases-investigated-Diabetes Mellitus', 'Mitochondrial Diseases-investigated-HIV Infections', 'Inflammation-increase-Reperfusion Injury', 'Dementia-challenge-Parkinson Disease, Secondary', 'Heart Failure-increased-Sleep Apnea Syndromes', 'Acute Disease-render-Vision Disorders', 'Cardiovascular Diseases-exhibit-Death', 'Exfoliation Syndrome-affect-Corneal Diseases', 'Isolated Noncompaction of the Ventricular Myocardium-undergo-Aortic Valve Stenosis', 'Neuralgia-control-Nervous System Diseases', 'Death-detected-Infections', 'Cross Infection-assess-Death', 'Wounds and Injuries-assess-Death', 'HIV Infections-associated-Drug-Related Side Effects and Adverse Reactions', 'Drug-Related Side Effects and Adverse Reactions-associated-HIV Infections', 'Metabolic Syndrome-affect-Asthma', 'Metabolic Syndrome-affect-Inflammation', 'Asthma-affect-Inflammation', 'Gallstones-manage-Cholecystitis', 'Atherosclerosis-contribute-Vascular Calcification', 'Vascular Calcification-discuss-Renal Insufficiency, Chronic', 'Diabetes Mellitus-contribute-Vascular Calcification', 'Vascular Calcification-discuss-Calciphylaxis', 'Renal Insufficiency, Chronic-contribute-Vascular Calcification', 'Heart Failure-increase-Venous Thrombosis', 'Pulmonary Disease, Chronic Obstructive-increase-Venous Thrombosis', 'Diabetes Mellitus-increase-Venous Thrombosis', 'Hemophilia A-include-Hemorrhage', 'Hemorrhage-include-von Willebrand Diseases', 'Hemorrhage-acquire-von Willebrand Diseases', 'von Willebrand Diseases-acquire-Hemorrhage', 'Osteoporosis-include-Bone Diseases', 'Neoplasms-include-Bone Diseases', 'Osteomalacia-include-Bone Diseases', 'Rickets, Hypophosphatemic-include-Bone Diseases', 'Osteochondrodysplasias-include-Bone Diseases', 'Renal Insufficiency, Chronic-include-Bone Diseases', 'Leg Ulcer-defined-Venous Thrombosis', 'Intracranial Embolism-associate-Stroke', 'Stroke-associate-Intracranial Embolism', 'Atrial Fibrillation-discover-Stroke', 'Sclerosis-associated-Dementia', 'Dementia-associated-Sclerosis', 'Cerebrovascular Disorders-noted-Sclerosis', 'Aortic Diseases-associated-Cerebrovascular Disorders', 'Cerebrovascular Disorders-associated-Aortic Diseases', 'Death-identified-Coma', 'Death-identified-Coronary Artery Disease', 'Sarcopenia-used-Muscle Spasticity', 'Fractures, Open-experience-Pain', 'Pain-affected-Sleep Initiation and Maintenance Disorders', 'Metabolic Syndrome-diagnosed-Obesity', 'Metabolic Syndrome-associated-Parkinson Disease', 'Parkinson Disease-associated-Metabolic Syndrome', 'Metabolic Syndrome-manage-Parkinson Disease', 'Pulmonary Disease, Chronic Obstructive-include-Inflammation', 'Infertility, Male-associated-Inflammation', 'Inflammation-associated-Infertility, Male', 'Infertility, Female-associated-Inflammation', 'Inflammation-associated-Infertility, Female', 'Infections-follow-Neoplasms', 'Death-include-Spinal Injuries', 'Rib Fractures-include-Death', 'Blindness-include-Communicable Diseases', 'Sleep Apnea Syndromes-convey-Stroke', 'Cerebellar Diseases-cancel-Cerebellar Ataxia', 'Cerebellar Ataxia-include-Ataxia', 'Tremor-include-Ataxia', 'Muscle Hypotonia-include-Ataxia', 'Amyloidosis-associated-Vision Disorders', 'Vision Disorders-associated-Amyloidosis', 'Chronic Disease-engaged-Obesity', 'Amyloidosis-associated-Atrophy', 'Atrophy-associated-Amyloidosis', 'Neoplasms-compromise-Seizures', 'Dysbiosis-enable-Neoplasms', 'Vascular Calcification-caused-Hypertension', 'Vascular Calcification-caused-Renal Insufficiency, Chronic', 'Vascular Calcification-caused-Diabetes Mellitus', 'Gastroesophageal Reflux-diagnose-Infections', 'Edema-occur-Hydrocephalus', 'Brain Diseases-occur-Hydrocephalus', 'Postoperative Cognitive Complications-considered-Dementia', 'Death-evaluate-Acute Coronary Syndrome', 'Fractures, Spontaneous-cause-Kidney Diseases', 'Neurodegenerative Diseases-cause-Infections', 'Memory Disorders-rescue-Alzheimer Disease', 'Intracranial Hemorrhages-include-Hemorrhage', 'Death-include-Hemorrhage', 'Thromboembolism-related-Atrial Fibrillation', 'Atrial Fibrillation-undertreated-Hemorrhage', 'HIV Infections-account-Death', 'Osteoporotic Fractures-assess-Neurologic Manifestations', 'Vision Disorders-contribute-Obesity', 'Vision Disorders-contribute-Diabetes Mellitus', 'Parkinson Disease-lead-Muscle Rigidity', 'Tremor-lead-Muscle Rigidity', 'Alzheimer Disease-played-Neurotoxicity Syndromes', 'Sensation Disorders-described-Alzheimer Disease', 'Obesity-associate-Coinfection', 'Coinfection-associate-Obesity', 'Infections-associate-Obesity', 'Obesity-associate-Infections', 'Turner Syndrome-identify-Fractures, Bone', 'Renal Insufficiency-associated-Sleep Wake Disorders', 'Sleep Wake Disorders-associated-Renal Insufficiency', 'Respiratory Tract Diseases-associated-Sleep Wake Disorders', 'Sleep Wake Disorders-associated-Respiratory Tract Diseases', 'Gastroesophageal Reflux-associated-Sleep Wake Disorders', 'Sleep Wake Disorders-associated-Gastroesophageal Reflux', 'Arthralgia-suffer-Chronic Disease', 'Fractures, Bone-elevated-Sleep Initiation and Maintenance Disorders', 'Parkinson Disease-suffer-Movement Disorders', 'Neurodegenerative Diseases-suffer-Movement Disorders', 'Death-remain-Fractures, Bone', 'Cardiovascular Diseases-associated-Psychomotor Disorders', 'Psychomotor Disorders-associated-Cardiovascular Diseases', 'Malnutrition-foster-Neoplasms', 'Neoplasms-recognized-Ovarian Neoplasms', 'Fistula-reveal-Hemorrhage', 'Coronary Artery Disease-suffer-Heart Arrest', 'Ataxia-assess-Sarcopenia', 'Myocardial Infarction-bring-Heart Failure', 'Hip Fractures-failing-Sleep Initiation and Maintenance Disorders', 'Hip Fractures-follow-Sleep Initiation and Maintenance Disorders', 'Diabetes Mellitus-evaluated-Weight Loss', 'Lung Neoplasms-underline-Carcinogenesis', 'Psychomotor Agitation-occur-Alzheimer Disease', 'Psychoses, Substance-Induced-occur-Alzheimer Disease', 'Autoimmune Diseases-associated-Dehydration', 'Dehydration-associated-Autoimmune Diseases', 'Renal Insufficiency, Chronic-coupled-Chronic Kidney Disease-Mineral and Bone Disorder', 'Renal Insufficiency, Chronic-coupled-Brain Infarction', 'Chronic Kidney Disease-Mineral and Bone Disorder-coupled-Brain Infarction', 'Fractures, Bone-result-Wounds and Injuries', 'Dementia-establish-Alzheimer Disease', 'Stroke-followed-Sclerosis', 'Neoplasms-followed-Epilepsy', 'Dementia-followed-Epilepsy', 'Epilepsy-followed-Sclerosis', 'Dysbiosis-result-Mouth Diseases', 'Glioblastoma-assumed-Glioma', 'Astrocytoma-assumed-Glioma', 'Atherosclerosis-prevent-Inflammation', 'Atherosclerosis-eliminate-Inflammation', 'Infarction-implanted-Myocardial Infarction', 'Drug-Related Side Effects and Adverse Reactions-include-Leishmaniasis', 'Coinfection-include-Leishmaniasis', 'Hepatitis, Viral, Human-include-Leishmaniasis', 'Death-remain-Renal Insufficiency, Chronic', 'Renal Insufficiency, Chronic-slow-Kidney Diseases', 'Diabetes Mellitus-become-Renal Insufficiency, Chronic', 'Aneurysm-shaping-Stroke', 'Death-predict-Epilepsy', 'Stroke-attributed-Cerebral Small Vessel Diseases', 'Atherosclerosis-appear-Stroke', 'Communicable Diseases-appear-Stroke', 'Stroke-portend-Dementia', 'Death-portend-Dementia', 'Cerebrovascular Disorders-ascribed-Communicable Diseases', 'Death-investigate-Head and Neck Neoplasms', 'Death-defined-Neoplasms', 'Neoplasms-predict-Head and Neck Neoplasms', 'Dementia-examined-Adrenal Insufficiency', 'Immunoglobulin Light-chain Amyloidosis-dictated-Death', 'Multiple Myeloma-treat-Immunoglobulin Light-chain Amyloidosis', 'Diabetes Mellitus-adjusted-Obesity', 'Anemia-impact-Death', 'Obesity-prevent-Weight Gain', 'Polycythemia Vera-include-Leukemia, Myelogenous, Chronic, BCR-ABL Positive', 'Thrombocythemia, Essential-include-Leukemia, Myelogenous, Chronic, BCR-ABL Positive', 'Primary Myelofibrosis-include-Leukemia, Myelogenous, Chronic, BCR-ABL Positive', 'Death-document-Pneumonia', 'Death-document-Neoplasms', 'Heart Failure-document-Pneumonia', 'Heart Failure-document-Neoplasms', 'Metabolic Diseases-begin-Heart Failure', 'Inflammatory Bowel Diseases-considered-Hypertension', 'Hemorrhage-define-Thrombosis', 'Wounds and Injuries-reduced-Death', 'Vascular Calcification-associated-Kidney Diseases', 'Kidney Diseases-associated-Vascular Calcification', 'Cardiovascular Diseases-fail-Vascular Calcification', 'Hypertrophy, Left Ventricular-fail-Vascular Calcification', 'Plaque, Amyloid-contribute-Psychoses, Substance-Induced', 'Erectile Dysfunction-increased-Hypertension', 'Alcoholism-associated-Erectile Dysfunction', 'Erectile Dysfunction-associated-Alcoholism', 'Mitochondrial Diseases-contribute-Chemical and Drug Induced Liver Injury', 'Drug-Related Side Effects and Adverse Reactions-include-Malnutrition', 'Drug-Related Side Effects and Adverse Reactions-include-Alcoholism', 'Drug-Related Side Effects and Adverse Reactions-include-Hepatitis C, Chronic', 'Drug-Related Side Effects and Adverse Reactions-include-Hepatitis B, Chronic', 'Drug-Related Side Effects and Adverse Reactions-include-HIV Infections', 'Drug-Related Side Effects and Adverse Reactions-include-Liver Diseases', 'Rheumatic Diseases-associated-Death', 'Death-associated-Rheumatic Diseases', 'Atrophy-cause-Ischemia', 'Atrophy-caused-Diabetes Mellitus', 'Chemical and Drug Induced Liver Injury-pertain-Mitochondrial Diseases', 'Diabetes Mellitus-experience-Atrophy', 'Atrophy-experience-Glomerulosclerosis, Focal Segmental', 'Restless Legs Syndrome-associated-Sleep Initiation and Maintenance Disorders', 'Sleep Initiation and Maintenance Disorders-associated-Restless Legs Syndrome', 'Diabetes Mellitus-include-Vision Disorders', 'HIV Infections-live-Osteoporosis', 'Neoplasms-obtain-Drug-Related Side Effects and Adverse Reactions', 'Diabetes Mellitus-develop-Renal Insufficiency, Chronic', 'Drug-Related Side Effects and Adverse Reactions-predict-Death', 'Hypertension-develop-Renal Insufficiency, Chronic', 'Dementia-diagnosed-Pain', 'Dementia-diagnosed-Heart Failure', 'Dementia-diagnosed-Hypertension', 'Dyslipidemias-consider-Hypothyroidism', 'Diabetes Mellitus-identified-Peptic Ulcer', 'Fibrosis-identified-Peptic Ulcer', 'Diabetes Mellitus-prevent-Sarcopenia', 'Bronchitis-include-Pulmonary Disease, Chronic Obstructive', 'Emphysema-include-Pulmonary Disease, Chronic Obstructive', 'Hip Fractures-provide-Osteoporosis', 'Multiple Sclerosis-associated-Leukoencephalopathy, Progressive Multifocal', 'Leukoencephalopathy, Progressive Multifocal-associated-Multiple Sclerosis', 'Craniocerebral Trauma-lead-Death', 'Neurodegenerative Diseases-prevent-Malnutrition', 'Neurodegenerative Diseases-prevent-Metabolic Diseases', 'Neurodegenerative Diseases-alleviate-Parakeratosis', 'Neurodegenerative Diseases-release-Psoriasis', 'Malnutrition-alleviate-Parakeratosis', 'Metabolic Diseases-alleviate-Parakeratosis', 'Breast Neoplasms-suppress-Neoplasms', 'Dementia-remain-Dementia, Vascular', 'Polycythemia Vera-considered-Chorea', 'Osteoporosis-follow-Diabetes Mellitus', 'Hypertension-associated-Hearing Disorders', 'Hearing Disorders-associated-Hypertension', 'Hearing Loss-take-Hearing Disorders', 'Diabetes Mellitus-associated-Hearing Disorders', 'Hearing Disorders-associated-Diabetes Mellitus', 'Hearing Disorders-interact-Hearing Loss', 'Cardiovascular Diseases-associated-Hearing Disorders', 'Hearing Disorders-associated-Cardiovascular Diseases', 'Asthma-associated-Signs and Symptoms, Respiratory', 'Signs and Symptoms, Respiratory-associated-Asthma', 'Brain Injuries, Traumatic-experience-Craniocerebral Trauma', 'Leukoencephalopathies-evaluate-Dementia', 'Infections-complicated-Endophthalmitis', 'Infections-result-Panophthalmitis', 'Endophthalmitis-result-Panophthalmitis', 'Endophthalmitis-complicated-Endocarditis', 'Endophthalmitis-complicated-Intracranial Embolism', 'Endophthalmitis-complicated-Hemorrhage', 'Endophthalmitis-complicated-Arthritis', 'Ischemia-recruited-Stroke', 'Eye Infections-develop-Panophthalmitis', 'Inflammation-induced-Stroke', 'Death-attributed-Mesenteric Vascular Occlusion', 'Mesenteric Vascular Occlusion-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-Mesenteric Vascular Occlusion', 'Diabetes Mellitus-double-Mesenteric Vascular Occlusion', 'Diabetes Mellitus-double-Death', 'Microvascular Angina-contribute-Cardiovascular Diseases', 'Gait Disorders, Neurologic-discuss-Sarcopenia', 'Gait Disorders, Neurologic-proposed-Musculoskeletal Diseases', 'Glucose Intolerance-control-HIV Infections', 'Diabetes Mellitus-control-HIV Infections', 'Communicable Diseases-treat-Infections', 'Prostatitis-lead-Infertility, Female', 'Orchitis-lead-Infertility, Female', 'Inflammation-linked-Arbovirus Infections', 'Alzheimer Disease-convert-Dementia', 'Hip Fractures-occur-Osteoporosis', 'Joint Diseases-characterized-Pain', 'Brain Injuries, Traumatic-result-Intra-Articular Fractures', 'Brain Injuries, Traumatic-result-Osteoarthritis', 'Intra-Articular Fractures-lead-Osteoarthritis', 'Wounds and Injuries-contribute-Osteoarthritis', 'Osteoarthritis-developed-Wounds and Injuries', 'Fractures, Bone-associated-Renal Tubular Transport, Inborn Errors', 'Renal Tubular Transport, Inborn Errors-associated-Fractures, Bone', 'Stroke-reveal-Hypertension', 'Stroke-reveal-Consciousness Disorders', 'Stroke-reveal-Pulmonary Embolism', 'Hypertension-reveal-Death', 'Consciousness Disorders-reveal-Death', 'Pulmonary Embolism-reveal-Death', 'Low Back Pain-treat-Osteoporosis', 'Renal Insufficiency, Chronic-define-Proteinuria', 'Inflammation-prevent-Hip Fractures', 'Inflammation-known-Necrosis', 'Inflammation-influence-Hip Fractures', 'Pneumonia-include-Fever', 'Pneumonia-include-Respiratory Sounds', 'Pneumonia-include-Respiratory Insufficiency', 'Inflammation-explored-Arthritis, Rheumatoid', 'Diabetes Mellitus-review-Obesity', 'Diabetes Mellitus-review-Prediabetic State', 'Sarcopenia-include-Neurodegenerative Diseases', 'Thromboembolism-include-Atrial Fibrillation', 'Death-include-Hypertension', 'Arthritis-occur-Death', 'Arthritis-occur-Cardiovascular Diseases', 'Liver Diseases-include-Chronic Disease', 'Diabetes Mellitus, Type 2-include-Chronic Disease', 'Coronary Artery Disease-control-Obesity', 'Coronary Artery Disease-control-Hypertension', 'Dementia-investigate-Delirium', 'Urinary Tract Infections-associated-Delirium', 'Delirium-associated-Urinary Tract Infections', 'Pulmonary Disease, Chronic Obstructive-predicted-Death', 'Carcinoma, Hepatocellular-include-HIV Infections', 'Hypertrophy-associated-Contracture', 'Contracture-associated-Hypertrophy', 'Seizures-measure-Dementia', 'Seizures-related-Dementia', 'Obesity, Abdominal-identified-Cardiovascular Diseases', 'Kidney Diseases-attributed-Inflammation', 'Neoplasms-attributed-Inflammation', 'Anophthalmos-cause-Vision, Low', 'Bacterial Infections-include-Chronic Disease', 'Alzheimer Disease-affected-Nerve Degeneration', 'Alzheimer Disease-affected-Neurodegenerative Diseases', 'Stroke-experience-Intracranial Aneurysm', 'Dyslipidemias-associated-Dementia, Vascular', 'Dementia, Vascular-associated-Dyslipidemias', 'Dyslipidemias-associated-Alzheimer Disease', 'Alzheimer Disease-associated-Dyslipidemias', 'Dementia-found-Dementia, Vascular', 'Malnutrition-improve-Hip Fractures', 'Low Back Pain-show-Sensation Disorders', 'Low Back Pain-show-Nociceptive Pain', 'Dementia-design-Alzheimer Disease', 'Glucose Metabolism Disorders-impact-Alzheimer Disease', 'Amnesia-incident-Alzheimer Disease', 'Amnesia-incident-Dementia', 'Neoplasms-predispose-Ovarian Diseases', 'Diabetes Mellitus-contribute-Edema', 'Macular Edema-manage-Werner Syndrome', 'Osteoporosis-experience-Osteoporotic Fractures', 'Fractures, Bone-experience-Osteoporosis', 'Fractures, Bone-experience-Osteoporotic Fractures', 'Fractures, Bone-experience-Neoplasms', 'Osteoporotic Fractures-defined-Fractures, Bone', 'Encephalitis, California-provide-Inflammation', 'Inflammation-alleviate-Neoplasms', 'Inflammation-alleviate-Dermatitis, Atopic', 'Inflammation-alleviate-Psoriasis', 'Fractures, Bone-present-Acute Pain', 'Chronic Disease-reduce-Asthma', 'Chronic Disease-reduce-Sleep Wake Disorders', 'Fragile X Syndrome-lead-Pain', 'Fragile X Syndrome-lead-Death', 'Fragile X Syndrome-improve-Pain', 'Osteoporosis-underlie-Fractures, Bone', 'Osteoporosis-underlie-Fragile X Syndrome', 'Hip Fractures-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-Hip Fractures', 'Sarcopenia-associated-Sleep Apnea, Obstructive', 'Sleep Apnea, Obstructive-associated-Sarcopenia', 'Osteogenesis Imperfecta-contribute-Osteoporosis', 'Death-precipitate-Infections', 'Diabetes Mellitus-achieve-Hypertension', 'Neoplasms-manage-Respiratory Tract Infections', 'Diverticulum-believed-Muscle Weakness', 'Diverticulum-believed-Colonic Neoplasms', 'Osteoarthritis-limited-Pain', 'Obesity-found-Hypertension', 'Obesity, Abdominal-found-Hypertension', 'Hyperglycemia-found-Hypertension', 'Hypertriglyceridemia-found-Hypertension', 'Voice Disorders-associated-Xerostomia', 'Xerostomia-associated-Voice Disorders', 'Hypertension-suffer-Paralysis', 'Hypertension-suffer-Hydrocephalus', 'Hypertension-suffer-Pneumonia', 'Language Disorders-detect-Dementia', 'Language Disorders-recognized-Dementia', 'Bone Diseases, Metabolic-associated-Osteoporosis', 'Osteoporosis-associated-Bone Diseases, Metabolic', 'Inflammation-improve-Death', 'Respiratory Tract Diseases-rise-Death', 'Heart Diseases-rise-Death', 'Lung Neoplasms-rise-Death', 'Airway Obstruction-used-Hirschsprung Disease', 'Hematologic Diseases-associated-Lymphoma, Non-Hodgkin', 'Lymphoma, Non-Hodgkin-associated-Hematologic Diseases', 'Hematologic Diseases-associated-Leukemia, Lymphocytic, Chronic, B-Cell', 'Leukemia, Lymphocytic, Chronic, B-Cell-associated-Hematologic Diseases', 'Hematologic Diseases-lead-Lymphoma, Non-Hodgkin', 'Hematologic Diseases-lead-Leukemia, Lymphocytic, Chronic, B-Cell', 'Peptic Ulcer-caused-Infections', 'Hemorrhage-decrease-Death', 'Hemorrhage-decrease-Critical Illness', 'Wounds and Injuries-develop-Multiple Organ Failure', 'Wounds and Injuries-termed-Critical Illness', 'Sepsis-develop-Multiple Organ Failure', 'Sepsis-decrease-Critical Illness', 'Sepsis-termed-Critical Illness', 'Multiple Organ Failure-defined-Critical Illness', 'Multiple Organ Failure-termed-Critical Illness', 'Inflammation-include-Osteoarthritis', 'Carcinoma, Hepatocellular-increase-Diabetes Mellitus', 'Hepatitis, Viral, Human-increase-Diabetes Mellitus', 'Fibrosis-follow-Hepatitis C', 'Carcinoma, Hepatocellular-follow-Hepatitis C', 'Hypertension-live-Dementia', 'Central Nervous System Neoplasms-include-Neoplasms', 'Alzheimer Disease-contribute-Bradycardia', 'Headache Disorders, Secondary-include-Hypogonadism', 'Hypoxia-characterized-Chronic Disease', 'Spinal Fractures-increase-Wounds and Injuries', 'Spinal Fractures-sustain-Death', 'Neoplasms-grow-Death', 'Albuminuria-correspond-Metabolic Syndrome', 'Coronary Artery Disease-correspond-Metabolic Syndrome', 'Cerebrovascular Disorders-correspond-Metabolic Syndrome', 'Peripheral Arterial Disease-correspond-Metabolic Syndrome', 'Dyslipidemias-associated-Communicable Diseases', 'Communicable Diseases-associated-Dyslipidemias', 'Hyperlipidemias-associated-Alzheimer Disease', 'Alzheimer Disease-associated-Hyperlipidemias', 'Osteoarthritis-associated-Alzheimer Disease', 'Alzheimer Disease-associated-Osteoarthritis', 'Acute Kidney Injury-characterized-Death', 'Lymphoma-perform-Lymphoma, Mantle-Cell', 'Neoplasms-perform-Lymphoma, Mantle-Cell', 'Death-include-Leukemia', 'Death-follow-Brain Injuries, Traumatic', 'Chronic Disease-lowering-Hip Fractures', 'Auditory Diseases, Central-show-Hearing Loss', 'Death-represent-Heart Diseases', 'Death-represent-Hypertension, Pulmonary', 'Sarcopenia-include-Dehydration', 'Hypertension, Pulmonary-increased-Heart Diseases', 'Brain Damage, Chronic-cause-Neurologic Manifestations', 'Metabolic Syndrome-trigger-Brain Diseases', 'Fatty Liver-develop-Fibrosis', 'Arthritis, Rheumatoid-affected-Carotid Artery Diseases', 'Arthritis, Rheumatoid-prevent-Mitochondrial Diseases', 'Intervertebral Disc Degeneration-cause-Back Pain', 'Atrophy-result-Memory Disorders', 'Peripheral Arterial Disease-include-Atherosclerosis', 'Pain-improve-Fractures, Bone', 'Hypertension-reduce-Kidney Diseases', 'Hypertension-reduce-Proteinuria', 'Proteinuria-include-Kidney Diseases', 'Obesity-associated-Hyperuricemia', 'Hyperuricemia-associated-Obesity', 'Obesity-reach-Dyslipidemias', 'Obesity-reach-Diabetes Mellitus', 'Obesity-reach-Hypertension', 'Obesity-reach-Hyperuricemia', 'Dementia-base-Diabetes Mellitus', 'Aneurysm-base-Diabetes Mellitus', 'Craniocerebral Trauma-base-Diabetes Mellitus', 'Hearing Loss-base-Diabetes Mellitus', 'Diabetes Mellitus-base-Cataract', 'Pneumonia-cause-Meningitis', 'Fractures, Bone-lead-Kidney Diseases', 'Osteoporotic Fractures-lead-Kidney Diseases', 'Death-decrease-Sepsis', 'Glaucoma-result-Blindness', 'Anemia-correlated-Death', 'Renal Insufficiency, Chronic-influence-Death, Sudden, Cardiac', 'Heart Failure-correlated-Death', 'Neoplasms-correlated-Death', 'Renal Insufficiency, Chronic-increase-Death, Sudden, Cardiac', 'Ocular Hypertension-develop-Hypertension', 'Ocular Hypertension-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-Ocular Hypertension', 'Stomach Neoplasms-assess-Sarcopenia', 'Cardiovascular Abnormalities-include-Neurodegenerative Diseases', 'Inflammation-contribute-Muscle Weakness', 'Sleep Wake Disorders-exhibit-Delirium', 'Musculoskeletal Diseases-decrease-Spasm', 'Heredodegenerative Disorders, Nervous System-lead-Urinary Bladder Diseases', 'Diabetes Mellitus-lead-Urinary Bladder Diseases', 'Synucleinopathies-correlate-Delirium', 'Fractures, Bone-develop-Osteonecrosis', 'Paralysis-develop-Osteonecrosis', 'Pain-show-Neoplasms', 'Ischemia-appear-Seizures', 'Fractures, Bone-associated-Hyperostosis, Diffuse Idiopathic Skeletal', 'Hyperostosis, Diffuse Idiopathic Skeletal-associated-Fractures, Bone', 'Dehydration-associated-Dementia', 'Dementia-associated-Dehydration', 'Metabolic Diseases-associated-Neoplasms', 'Neoplasms-associated-Metabolic Diseases', 'Renal Insufficiency-maintain-Fractures, Bone', 'Fetal Macrosomia-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-Fetal Macrosomia', 'Nervous System Diseases-improve-Parkinson Disease', 'Neoplasm Invasiveness-affect-Chordoma', 'Acute Coronary Syndrome-undertreat-Death', 'Chest Pain-undertreat-Death', 'Death-defined-Myocardial Infarction', 'Death-defined-Heart Arrest', 'Death-defined-Venous Thromboembolism', 'Death-defined-Respiratory Insufficiency', 'Death-defined-Infections', 'Death-defined-Pneumonia', 'Death-defined-Acute Kidney Injury', 'Death-defined-Coma', 'Sarcopenia-found-Fasciculation', 'Sarcopenia-found-Atrophy', 'Fasciculation-found-Sarcopenia', 'Atrophy-found-Sarcopenia', 'Neoplasms-predisposed-Fractures, Bone', 'Fractures, Bone-predisposed-Wounds and Injuries', 'Progeria-lead-Cardiovascular Diseases', 'Synovitis-associated-Pain', 'Pain-associated-Synovitis', 'Genetic Diseases, Inborn-characterized-Cardiovascular Diseases', 'Paraproteinemias-associated-Multiple Myeloma', 'Multiple Myeloma-associated-Paraproteinemias', 'Cerebral Amyloid Angiopathy-increase-Hemorrhage', 'Alzheimer Disease-become-Brain Diseases', 'Brain Diseases-involved-Alzheimer Disease', 'Alzheimer Disease-subjected-Brain Diseases', 'Chronic Disease-reduce-Pneumonia', 'Spinal Cord Diseases-occur-Substance-Related Disorders', 'Sepsis-followed-Pneumonia', 'Neoplasms-correlate-Pelizaeus-Merzbacher Disease', 'Neoplasm Metastasis-associated-Alcoholism', 'Alcoholism-associated-Neoplasm Metastasis', 'Neoplasm Metastasis-associated-Hepatitis B', 'Hepatitis B-associated-Neoplasm Metastasis', 'Hemorrhage-include-Thrombosis', 'Heart Valve Diseases-manifest-Pulmonary Valve Stenosis', 'Heart Valve Diseases-manifest-Aortic Valve Insufficiency', 'Tuberculosis-compounded-Diabetes Mellitus', 'Idiopathic Pulmonary Fibrosis-provide-Pneumonia', 'Pain-include-Upper Extremity Deformities, Congenital', 'Critical Illness-contribute-Neoplasms', 'Keratosis, Actinic-include-Acrocephalosyndactylia', 'Cardiomyopathy, Dilated-induce-Heart Failure', 'Cardiomyopathy, Dilated-induce-Syncope', 'Tachycardia-induce-Heart Failure', 'Tachycardia-induce-Syncope', 'Heart Failure-induce-Tachycardia, Ventricular', 'Tachycardia, Ventricular-induce-Syncope', 'Sepsis-combine-Death', 'Hyperlactatemia-compare-Death', 'Hyperlactatemia-compare-Sepsis', 'Muscular Diseases-induced-Obesity', 'Sarcopenia-remain-Lung Neoplasms', 'Death-related-Spinal Cord Injuries', 'Death-compare-Cardiovascular Diseases', 'Breast Neoplasms-express-Neoplasms', 'Myalgia-recognised-Myocardial Infarction', 'Cough-recognised-Myocardial Infarction', 'Neck Pain-recognised-Myocardial Infarction', 'Myocardial Infarction-emerge-Chest Pain', 'Hyperglycemia-show-Metabolic Syndrome', 'Hyperglycemia-show-Dementia', 'Dementia-wait-Metabolic Diseases', 'Adrenoleukodystrophy-associated-Sleep Wake Disorders', 'Sleep Wake Disorders-associated-Adrenoleukodystrophy', 'Amyotrophic Lateral Sclerosis-characterized-Muscular Atrophy', 'Amyotrophic Lateral Sclerosis-characterized-Respiratory Tract Infections', 'Muscular Atrophy-characterized-Respiratory Tract Infections', 'Osteoarthritis-associated-Hyperalgesia', 'Hyperalgesia-associated-Osteoarthritis', 'Joint Diseases-protect-Osteoarthritis', 'Cardiomyopathies-exhibit-Arrhythmias, Cardiac', 'Cardiomyopathies-exhibit-Heart Failure', 'Myopia-defined-Hyperopia', 'Myopia-defined-Astigmatism', 'Myopia-control-Astigmatism', 'Multiple Sclerosis-detect-Alzheimer Disease', 'Alzheimer Disease-derived-Multiple Sclerosis', 'Memory Disorders-merit-Dementia', 'Multiple Sclerosis-merit-Dementia', 'Obesity-report-Low Back Pain', 'Deglutition Disorders-associated-Death', 'Death-associated-Deglutition Disorders', 'Substance-Related Disorders-associated-Death', 'Death-associated-Substance-Related Disorders', 'Airway Obstruction-associated-Death', 'Death-associated-Airway Obstruction', 'Cataract-consider-Ocular Hypertension', 'Alzheimer Disease-show-Keratitis, Dendritic', 'Liver Diseases-include-Carcinoma, Hepatocellular', 'Pain-lead-Death', 'Xeroderma Pigmentosum-characterized-Hyperpigmentation', 'Skin Diseases-characterized-Hyperpigmentation', 'Death-predict-Sarcopenia', 'Infections-caused-Communicable Diseases', 'Death-caused-Communicable Diseases', 'Malnutrition-aggravate-Infections', 'Obesity-aggravate-Infections', 'Cerebral Infarction-come-Atrial Fibrillation', 'Thromboembolism-prevent-Stroke', 'Stroke-prevenT-Embolism', 'Atrial Fibrillation-prevenT-Embolism', 'Embolism-prevenT-Stroke', 'Neoplasms-implicate-Chromothripsis', 'Li-Fraumeni Syndrome-implicate-Chromothripsis', 'Chromothripsis-implicated-Neoplasms', 'Chromothripsis-implicated-Infertility, Male', 'Neuralgia-related-Exanthema', 'Inflammatory Bowel Diseases-associated-Diverticulitis', 'Diverticulitis-associated-Inflammatory Bowel Diseases', 'Inflammatory Bowel Diseases-associated-Colitis', 'Colitis-associated-Inflammatory Bowel Diseases', 'Inflammation-increased-Death', 'Inflammatory Bowel Diseases-studied-Adrenal Insufficiency', 'Inflammatory Bowel Diseases-develop-Colorectal Neoplasms', 'Inflammatory Bowel Diseases-considered-Colorectal Neoplasms', 'Respiratory Tract Infections-lead-Bronchiolitis', 'Death-block-Neurodegenerative Diseases', 'Death-prevent-Neoplasms', 'Cerebrovascular Disorders-associated-Cerebral Small Vessel Diseases', 'Cerebral Small Vessel Diseases-associated-Cerebrovascular Disorders', 'Fractures, Bone-suffer-Nervous System Diseases', 'Fractures, Bone-suffer-Delirium', 'Nervous System Diseases-suffer-Delirium', 'Death-incur-Neoplasms', 'Central Nervous System Neoplasms-obtained-Neoplasms', 'Central Nervous System Neoplasms-obtained-Hodgkin Disease', 'Sarcopenia-associated-Communicable Diseases', 'Communicable Diseases-associated-Sarcopenia', 'Cataract-undergo-AIDS-Related Complex', 'AIDS-Related Complex-undergo-Ocular Hypertension', 'Fever-evaluate-Brain Ischemia', 'Dyspareunia-prevent-Osteoporosis', 'Sleep Initiation and Maintenance Disorders-prevent-Osteoporosis', 'Death-predicted-Hypotension', 'Death-predicted-Fractures, Bone', 'Asthma-identify-Drug Hypersensitivity', 'Death-promote-Drug-Related Side Effects and Adverse Reactions', 'Pneumonia-follow-Fever', 'Fever-followed-Chemical and Drug Induced Liver Injury', 'Fever-followed-Pneumonia', 'Pneumonia-tend-Fever', 'Pneumonia-tend-Chemical and Drug Induced Liver Injury', 'Diabetes Mellitus-nondiabete-Acute Kidney Injury', 'Acute Kidney Injury-increase-Diabetes Mellitus', 'Fragile X Syndrome-include-Pulmonary Embolism', 'Neoplasms-include-Pulmonary Embolism', 'Ventricular Dysfunction, Right-include-Pulmonary Embolism', 'Immunologic Deficiency Syndromes-identified-Headache Disorders, Secondary', 'Inflammation-accepted-Chronic Disease', 'Hematoma, Subdural, Chronic-occur-Wounds and Injuries', 'Cardiac Output, Low-persist-Alcoholism', 'Dermatitis, Atopic-develop-Rhinitis, Allergic', 'Dermatitis, Atopic-develop-Asthma', 'Cerebrovascular Disorders-superimpose-Leukoaraiosis', 'Leukoencephalopathies-associated-Constriction, Pathologic', 'Constriction, Pathologic-associated-Leukoencephalopathies', 'Osteoporotic Fractures-related-Death', 'Werner Syndrome-characterized-Diabetes Mellitus, Type 1', 'Werner Syndrome-characterized-Osteoporosis', 'Werner Syndrome-characterized-Spinocerebellar Degenerations', 'Werner Syndrome-characterized-Hypertriglyceridemia', 'Werner Syndrome-characterized-Sarcoma', 'Genetic Diseases, Inborn-characterized-Diabetes Mellitus, Type 1', 'Genetic Diseases, Inborn-characterized-Spinocerebellar Degenerations', 'Genetic Diseases, Inborn-characterized-Hypertriglyceridemia', 'Genetic Diseases, Inborn-characterized-Sarcoma', 'Neoplasms-characterize-Glioblastoma', 'Dementia-assess-Sleepiness', 'Cerebral Infarction-induced-Infarction, Middle Cerebral Artery', 'Infarction-aggravate-Neurologic Manifestations', 'Infarction-compare-Stroke', 'Infarction-aggravate-Stroke', 'Neurologic Manifestations-aggravate-Stroke', 'Neoplasms-include-Stroke', 'Infarction-attenuate-Stroke', 'Neurologic Manifestations-attenuate-Stroke', 'Nerve Degeneration-attenuate-Stroke', 'Gait Disorders, Neurologic-related-Hypertension', 'Atrial Fibrillation-assessed-Stroke', 'Neoplasms-ignored-Atrial Fibrillation', 'Gait Disorders, Neurologic-treat-Osteoporosis', 'Pigmentation Disorders-accelerate-Inflammation', 'Brain Edema-accompany-Cerebral Infarction', 'Atherosclerosis-render-Infarction', 'Kidney Diseases-show-Nephrotic Syndrome', 'Glomerulonephritis-show-Nephrotic Syndrome', 'Diabetes Mellitus-diagnosed-Anemia', 'Anemia-diagnosed-Diabetes, Gestational', 'Death-develop-Kidney Failure, Chronic', 'Cardiovascular Diseases-develop-Kidney Failure, Chronic', 'Coronary Artery Disease-concerened-Death', 'Cardiovascular Diseases-correlated-Sarcopenia', 'Wounds and Injuries-take-Craniocerebral Trauma', 'Intracranial Hemorrhages-activate-Wounds and Injuries', 'Wounds and Injuries-survive-Craniocerebral Trauma', 'Progeria-compared-Periodontal Diseases', 'Diabetes Mellitus-increase-Obesity', 'Sleep Apnea, Obstructive-associated-Pulmonary Disease, Chronic Obstructive', 'Pulmonary Disease, Chronic Obstructive-associated-Sleep Apnea, Obstructive', 'Pulmonary Disease, Chronic Obstructive-associated-Asthma-Chronic Obstructive Pulmonary Disease Overlap Syndrome', 'Asthma-Chronic Obstructive Pulmonary Disease Overlap Syndrome-associated-Pulmonary Disease, Chronic Obstructive', 'Blindness-affected-Retinal Dystrophies', 'Melanoma-develop-Arteritis', 'Trismus-related-Ataxia', 'Hyperkinesis-associated-Perceptual Disorders', 'Perceptual Disorders-associated-Hyperkinesis', 'Nervous System Diseases-identify-Dementia', 'Retinal Degeneration-related-Dementia', 'Retinal Degeneration-identify-Dementia', 'Cardiovascular Diseases-show-Death', 'Multiple Organ Failure-show-Death', 'Alzheimer Disease-involve-Voice Disorders', 'Insulin Resistance-involve-Alzheimer Disease', 'Neurogenic Inflammation-involve-Alzheimer Disease', 'Metabolic Syndrome-involve-Alzheimer Disease', 'Retinal Degeneration-involve-Alzheimer Disease', 'Alzheimer Disease-involve-Sleep Wake Disorders', 'Cardiovascular Abnormalities-involve-Alzheimer Disease', 'Urinary Incontinence-used-Diabetes Mellitus', 'Urinary Incontinence-used-Hypertension', 'Urinary Incontinence-used-Stroke', 'Urinary Incontinence-used-Ischemia', 'Stroke-increase-Urinary Incontinence', 'Hypertension-increase-Urinary Incontinence', 'Death-prevent-Coronary Artery Disease', 'Death-prevent-Stroke', 'Death-prevent-Dementia', 'Death-result-Lung Neoplasms', 'Amenorrhea-report-Fatigue', 'Amenorrhea-report-Cardiac Output, Low', 'Seizures-promote-Dementia', 'Sarcopenia-detected-Neoplasms', 'Sarcopenia-overlooked-Obesity', 'Neoplasms-suggested-Muscular Diseases', 'Communicable Diseases-suggested-Muscular Diseases', 'Death-threat-Obesity', 'Death-threat-Diabetes Mellitus', 'Atherosclerosis-progress-Cardiovascular Diseases', 'Supranuclear Palsy, Progressive-include-Tauopathies', 'Sarcopenia-compare-Osteoporosis', 'Sarcopenia-compare-Fractures, Bone', 'Wounds and Injuries-treated-Craniocerebral Trauma', 'Wounds and Injuries-treated-Severe Acute Respiratory Syndrome', 'Death-present-Wounds and Injuries', 'Bone Diseases-opening-Genetic Diseases, Inborn', 'Melanoma-fit-Seizures', 'Neurodegenerative Diseases-present-Taste Disorders', 'Adrenal Insufficiency-reduce-Ankle Injuries', 'Atrophy-compare-Dementia', 'Atrophy-increase-Dementia', 'Osteosarcoma-occur-Neoplasms', 'Diabetic Foot-propagated-Infections', 'Progeria-exhibit-Myocardial Infarction', 'Diabetic Foot-complicated-Osteomyelitis', 'Diabetic Foot-complicated-Fever', 'Osteomyelitis-presented-Fever', 'Osteomyelitis-presented-Syncope', 'Osteomyelitis-presented-Tachycardia', 'Death-identify-Atherosclerosis', 'Death-identify-Progeria', 'Lewy Body Disease-help-Hallucinations', 'Dementia-help-Hallucinations', 'Hepatitis B, Chronic-understand-Carcinoma, Hepatocellular', 'Hepatitis B, Chronic-show-Carcinoma, Hepatocellular', 'Pain-base-Osteoarthritis', 'Sepsis-switched-Infections', 'Heart Failure-increase-Hypertension', 'Polyneuropathies-arise-Vitamin A Deficiency', 'Polyneuropathies-arise-Drug Overdose', 'Neoplasms-gain-Nervous System Diseases', 'Neoplasms-gain-Kidney Diseases', 'Cardiovascular Diseases-evaluate-Peripheral Arterial Disease', 'Glomerulonephritis-caused-Vasculitis', 'Cardiovascular Diseases-associated-Arrhythmias, Cardiac', 'Arrhythmias, Cardiac-associated-Cardiovascular Diseases', 'Neurodegenerative Diseases-associated-Asthma', 'Asthma-associated-Neurodegenerative Diseases', 'Neurodegenerative Diseases-associated-Liver Diseases', 'Liver Diseases-associated-Neurodegenerative Diseases', 'Asthma-associated-Liver Diseases', 'Liver Diseases-associated-Asthma', 'Asthma-associated-Neoplasms', 'Neoplasms-associated-Asthma', 'Pancreatitis-associated-Fibrosis', 'Fibrosis-associated-Pancreatitis', 'Pancreatitis-associated-Atrophy', 'Atrophy-associated-Pancreatitis', 'Breast Neoplasms-vary-Neoplasms', 'Metabolic Syndrome-decrease-Hyperglycemia', 'Hypertriglyceridemia-decrease-Hyperglycemia', 'Epilepsy-associated-Seizures', 'Seizures-associated-Epilepsy', 'Epilepsy-associated-Chemical and Drug Induced Liver Injury', 'Chemical and Drug Induced Liver Injury-associated-Epilepsy', 'Pulmonary Disease, Chronic Obstructive-develop-Emphysema', 'Death-observed-Leukemia, Myeloid, Acute', 'Drug-Related Side Effects and Adverse Reactions-include-Progeria', 'Drug-Related Side Effects and Adverse Reactions-underlie-Progeria', 'Atherosclerosis-show-Constriction, Pathologic', 'Pneumonia-show-Motor Neuron Disease', 'Fever-show-Motor Neuron Disease', 'Inflammation-develop-Optic Nerve Diseases', 'Aortic Coarctation-go-Hypertension', 'Heart Diseases-go-Hypertension', 'Colorectal Neoplasms-show-Death', 'Ischemia-increase-Hemorrhage', 'Headache Disorders, Secondary-show-Perceptual Disorders', 'Stroke-facilitate-Cerebral Infarction', 'Pain-attributed-Osteoarthritis', 'Obesity-contribute-Psychoses, Substance-Induced', 'Dyslipidemias-contribute-Psychoses, Substance-Induced', 'Corneal Diseases-break-Dry Eye Syndromes', 'Nerve Degeneration-observed-Neurodegenerative Diseases', 'Soft Tissue Infections-accompany-Discitis', 'Hypertension-found-Aortic Valve Insufficiency', 'Pleural Effusion-investigate-Death', 'Cerebrospinal Fluid Otorrhea-suffer-Sclerosis', 'Cerebrospinal Fluid Otorrhea-suffer-Hypertension', 'Fibrosis-confer-Death', 'Fibrosis-confer-Solitary Fibrous Tumor, Pleural', 'Hemorrhage-confer-Death', 'Heart Failure-increasing-Obesity', 'Hemorrhage-confer-Solitary Fibrous Tumor, Pleural', 'Carcinoma, Hepatocellular-confer-Death', 'Carcinoma, Hepatocellular-confer-Solitary Fibrous Tumor, Pleural', 'Hepatic Encephalopathy-confer-Death', 'Hepatic Encephalopathy-confer-Solitary Fibrous Tumor, Pleural', 'Pneumonia-confer-Death', 'Pneumonia-confer-Solitary Fibrous Tumor, Pleural', 'Kidney Diseases-confer-Death', 'Kidney Diseases-confer-Solitary Fibrous Tumor, Pleural', 'Diabetic Cardiomyopathies-increasing-Diabetes Mellitus', 'Diabetic Cardiomyopathies-characterized-Fibrosis', 'Diabetic Cardiomyopathies-characterized-Ventricular Remodeling', 'Heart Diseases-impair-Inflammation', 'Diabetic Cardiomyopathies-characterized-Hypotension', 'Diabetic Cardiomyopathies-characterized-Heart Diseases', 'Diabetic Cardiomyopathies-characterized-Heart Failure', 'Diabetes Mellitus-lead-Cardiomyopathies', 'Diabetes Mellitus-lead-Coronary Artery Disease', 'Diabetes Mellitus-lead-Heart Valve Diseases', 'Diabetes Mellitus-lead-Hypertension', 'Inflammation-implicated-Diabetic Cardiomyopathies', 'Diabetes Mellitus-lead-Dyslipidemias', 'Diabetes Mellitus-lead-Diabetic Cardiomyopathies', 'Heart Diseases-implicated-Diabetic Cardiomyopathies', 'Microvascular Angina-implicated-Diabetic Cardiomyopathies', 'Metabolic Syndrome-implicated-Diabetic Cardiomyopathies', 'Infertility, Female-associated-Polycystic Ovary Syndrome', 'Polycystic Ovary Syndrome-associated-Infertility, Female', 'Infertility, Female-associated-Endometriosis', 'Endometriosis-associated-Infertility, Female', 'Infertility, Female-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-Infertility, Female', 'Sarcopenia-lead-Fractures, Bone', 'Renal Insufficiency, Chronic-develop-Atrial Fibrillation', 'Sarcopenia-diagnosed-Osteoporosis', 'Genetic Diseases, Inborn-develop-Aneuploidy', 'Osteoporosis-defined-Sialic Acid Storage Disease', 'Death-compared-Hemorrhage', 'Fibrosis-include-Hypotension', 'Cardiomegaly-include-Hypotension', 'Heart Failure-characterized-Heart Failure, Diastolic', 'Essential Tremor-develop-Ventricular Fibrillation', 'Syncope-develop-Ventricular Fibrillation', 'Osteoporosis-include-Neurodegenerative Diseases', 'Contusions-develop-Ventricular Fibrillation', 'Hypertension-incorporate-Coronary Artery Disease', 'Obesity-experience-Cardiac Output, Low', 'Chronic Disease-associated-Metabolic Syndrome', 'Metabolic Syndrome-associated-Chronic Disease', 'Aneuploidy-detected-Alzheimer Disease', 'Aneuploidy-associated-Alzheimer Disease', 'Alzheimer Disease-associated-Aneuploidy', 'Aneuploidy-associated-Nerve Degeneration', 'Nerve Degeneration-associated-Aneuploidy', 'Wounds and Injuries-associated-Pneumonia', 'Pneumonia-associated-Wounds and Injuries', 'Parkinson Disease-suffer-Obesity', 'Parkinson Disease-suffer-Heart Failure', 'Parkinson Disease-suffer-Vision Disorders', 'Parkinson Disease-evaluate-Metabolic Syndrome', 'Parkinson Disease-suffer-Pain', 'Obesity-evaluate-Metabolic Syndrome', 'Atrophy-associated-Epilepsy, Temporal Lobe', 'Epilepsy, Temporal Lobe-associated-Atrophy', 'Epilepsy, Temporal Lobe-experience-Memory Disorders', 'Memory Disorders-reflect-Neurologic Manifestations', 'Epilepsy, Temporal Lobe-reflect-Neurologic Manifestations', 'Cardiovascular Diseases-induce-Dysbiosis', 'Obesity-induce-Dysbiosis', 'Dysbiosis-associated-Inflammation', 'Inflammation-associated-Dysbiosis', 'Death-increase-Lung Neoplasms', 'Respiratory Tract Diseases-increase-Lung Neoplasms', 'Respiratory Tract Diseases-increase-Death', 'Lung Neoplasms-increase-Death', 'Shock, Cardiogenic-develop-Multiple Organ Failure', 'Shock, Cardiogenic-develop-Fever', 'Shock, Cardiogenic-develop-Acute Coronary Syndrome', 'Infarction-improve-Stroke', 'Multiple Organ Failure-develop-Acute Coronary Syndrome', 'Death-develop-Acute Coronary Syndrome', 'Fever-develop-Acute Coronary Syndrome', 'Endocarditis-develop-Acute Coronary Syndrome', 'Immunologic Deficiency Syndromes-cause-Cardiovascular Diseases', 'Renal Insufficiency, Chronic-characterized-Immunologic Deficiency Syndromes', 'Chronic Kidney Disease-Mineral and Bone Disorder-characterized-Immunologic Deficiency Syndromes', 'Osteoporosis-coexist-Atherosclerosis', 'Diabetes Mellitus, Type 2-confer-Dementia', 'Diabetes Mellitus, Type 2-confer-Alzheimer Disease', 'Diabetes Mellitus, Type 2-associated-Infarction', 'Infarction-associated-Diabetes Mellitus, Type 2', 'Diabetes Mellitus, Type 2-mediated-Aneurysm', 'Infarction-mediated-Aneurysm', 'Dementia-mediated-Aneurysm', 'Sarcopenia-include-Muscular Diseases', 'Sarcopenia-seen-Inflammation', 'Sarcopenia-seen-Mitochondrial Diseases', 'Anorexia-validate-Sarcopenia', 'Fatigue-defined-Neoplasms', 'Neoplasms-benefit-Multiple Organ Failure', 'Myelodysplastic Syndromes-approach-Leukemia, Myeloid, Acute', 'Diabetes Mellitus-compare-Kidney Diseases', 'Osteoarthritis-emerging-Fibrosis', 'Osteoarthritis-associated-Synovitis', 'Synovitis-associated-Osteoarthritis', 'Vision Disorders-show-Hypertension', 'Diabetes Mellitus-present-Joint Diseases', 'Lymphoma-increasing-HIV Infections', 'Sleep Wake Disorders-affect-Heredodegenerative Disorders, Nervous System', 'Inflammation-intertwined-Pulmonary Disease, Chronic Obstructive', 'Inflammation-implicated-HIV Infections', 'Fractures, Bone-include-Carpal Tunnel Syndrome', 'Fractures, Bone-include-Tenosynovitis', 'HIV Infections-play-Inflammation', 'Carpal Tunnel Syndrome-associated-Fractures, Bone', 'Fractures, Bone-associated-Carpal Tunnel Syndrome', 'Neurotoxicity Syndromes-become-Neurodegenerative Diseases', 'Sclerosis-include-Neurodegenerative Diseases', 'Diabetes Mellitus-develop-Hypertension', 'Diabetes Mellitus-accelerate-Diabetic Nephropathies', 'Peripheral Arterial Disease-associated-Myocardial Infarction', 'Myocardial Infarction-associated-Peripheral Arterial Disease', 'Death-prepare-Diabetes Mellitus', 'Death-prepare-Tuberculosis', 'Ocular Motility Disorders-play-Carcinogenesis', 'Death-include-Inflammation', 'Death-involved-Inflammation', 'Diabetic Nephropathies-influenced-Kidney Diseases', 'Muscular Atrophy-prompt-Sarcopenia', 'Sarcopenia-prompt-Cerebral Palsy', 'Acute Kidney Injury-caused-Sepsis', 'Acute Kidney Injury-deny-Neoplasms', 'Acute Kidney Injury-include-Kidney Neoplasms', 'Hyperuricemia-associated-Kidney Failure, Chronic', 'Kidney Failure, Chronic-associated-Hyperuricemia', 'Erectile Dysfunction-linked-Prostatic Hyperplasia', 'Atrial Fibrillation-lead-Cerebral Infarction', 'Arrhythmias, Cardiac-lead-Cerebral Infarction', 'Acute Coronary Syndrome-prevent-Cerebral Infarction', 'Diabetes Mellitus-prevent-Cerebral Infarction', 'Diabetes Mellitus-reduce-Hemorrhage', 'Neoplasms-prevent-Cerebral Infarction', 'Neoplasms-reduce-Hemorrhage', 'Cerebral Infarction-reduce-Hemorrhage', 'Pain-involve-Cancer Pain', 'Pain-observe-Fractures, Bone', 'Urinary Bladder, Overactive-involve-Hypothalamic Neoplasms', 'Death-need-Pneumonia', 'Calcinosis-associated-Nerve Degeneration', 'Nerve Degeneration-associated-Calcinosis', 'Cardiac Output, Low-defined-Neoplasm Metastasis', 'Death-attributed-Kidney Diseases', 'Death-attributed-Respiratory Tract Diseases', 'Prostatic Neoplasms-focus-Neoplasms', 'Obesity-account-Death', 'Hemorrhage-affect-Pericardial Effusion', 'Hematologic Neoplasms-associated-Hemophilia A', 'Hemophilia A-associated-Hematologic Neoplasms', 'Osteoporosis-inhibit-Bisphosphonate-Associated Osteonecrosis of the Jaw', 'Malnutrition-detected-Neoplasms', 'Neoplasms-live-Malnutrition', 'Breast Neoplasms-inhibit-Neoplasms', 'Breast Neoplasms-focus-Liver Failure', 'Prostatic Neoplasms-focus-Liver Failure', 'Leukemia-inhibit-Neoplasms', 'Melanoma-inhibit-Neoplasms', 'Neoplasms-focus-Liver Failure', 'Neoplasms-induce-Liver Failure', 'Hypertension-develop-Heart Failure', 'Graft vs Host Disease-reconsidered-Leukemia, Myeloid, Acute', 'Xeroderma Pigmentosum-belong-Genetic Diseases, Inborn', 'Hypotension, Orthostatic-mediated-Vascular System Injuries', 'Wounds and Injuries-induced-Status Epilepticus', 'Seizures-abolish-Status Epilepticus', 'Status Epilepticus-modify-Epilepsy', 'Wounds and Injuries-modify-Epilepsy', 'Status Epilepticus-curtail-Brain Injuries', 'Status Epilepticus-curtail-Neurogenic Inflammation', 'Brain Injuries-thwart-Epilepsy', 'Neurogenic Inflammation-thwart-Epilepsy', 'Epilepsy-typified-Seizures', 'Epilepsy-associated-Inflammation', 'Inflammation-associated-Epilepsy', 'Hypertension-suggested-Alzheimer Disease', 'Alzheimer Disease-represent-Death', 'Heat Exhaustion-cause-Hereditary Angioedema Type III', 'Heat Exhaustion-cause-Dyspareunia', 'Hereditary Angioedema Type III-cause-Dyspareunia', 'Sphingolipidoses-associated-Alzheimer Disease', 'Alzheimer Disease-associated-Sphingolipidoses', 'Chronic Disease-become-Infections', 'Neurotoxicity Syndromes-cause-Dementia', 'Cardiovascular Diseases-characterized-Cardiomyopathies', 'Cardiovascular Diseases-characterized-Atherosclerosis', 'Crohn Disease-show-Colonic Neoplasms', 'Neoplasms-include-Chondrosarcoma', 'Neoplasms-affect-Chondrosarcoma', 'Osteosarcoma-affect-Chondrosarcoma', 'Osteoarthritis-implicated-Chondrosarcoma', 'Chondrosarcoma-assumed-Neoplasms', 'Aneurysm-play-Thrombosis', 'Aneurysm-share-Retinal Degeneration', 'Neuromuscular Junction Diseases-compare-Parkinson Disease', 'Parkinson Disease-display-Neuromuscular Junction Diseases', 'Neuromuscular Junction Diseases-impacted-Parkinson Disease', 'Hypertension-associated-Pheochromocytoma', 'Pheochromocytoma-associated-Hypertension', 'Pheochromocytoma-form-Hypertension', 'Neuroendocrine Tumors-form-Hypertension', 'Cholangitis-approach-Jaundice, Obstructive', 'Eosinophilia-implement-Cholangitis', 'Cerebrovascular Disorders-cause-Ischemia', 'Cerebrovascular Disorders-cause-Stroke', 'Death, Sudden-represent-Heart Diseases', 'Cerebral Small Vessel Diseases-account-Cerebral Hemorrhage', 'Takotsubo Cardiomyopathy-considered-Dyspnea', 'Takotsubo Cardiomyopathy-considered-Chest Pain', 'Cerebral Small Vessel Diseases-account-Cerebral Infarction', 'Death, Sudden, Cardiac-involve-Coronary Artery Disease', 'Death-involve-Coronary Artery Disease', 'Death-associated-Channelopathies', 'Channelopathies-associated-Death', 'Vision Disorders-associated-Obesity', 'Obesity-associated-Vision Disorders', 'Osteoporosis-begin-Osteoporotic Fractures', 'Osteoporosis-decrease-Osteoporotic Fractures', 'Hypotension-stimulate-Cardiomyopathies', 'Fibrosis-lead-Hypotension', 'Genetic Diseases, Inborn-cause-Vision Disorders', 'Cough-impaired-Stroke', 'Cough-lead-Pneumonia, Aspiration', 'Kidney Diseases-lead-Renal Insufficiency, Chronic', 'Renal Insufficiency, Chronic-live-Hypertension', 'Renal Insufficiency, Chronic-live-Diabetes Mellitus', 'Glaucoma-indicated-Cataract', 'Synovitis-characterized-Inflammation', 'Polymyalgia Rheumatica-represent-Rheumatic Fever', 'Dementia-increased-Atrial Fibrillation', 'Inflammation-recognized-Cardiovascular Diseases', 'Inflammation-underlie-Cardiovascular Diseases', 'Inflammation-recognized-Arrhythmias, Cardiac', 'Inflammation-underlie-Arrhythmias, Cardiac', 'Inflammation-recognized-Death, Sudden', 'Inflammation-underlie-Death, Sudden', 'Atrial Fibrillation-receive-Stroke', 'Dementia-receive-Stroke', 'Diabetes Mellitus-offset-Obesity', 'Diabetes Mellitus-promote-Obesity', 'Death-spent-HIV Infections', 'Diabetes Mellitus-underlie-Death', 'Hemophilia A-characterised-Hemorrhage', 'Respiratory Tract Infections-develop-Miller Fisher Syndrome', 'Respiratory Tract Infections-found-Gastrointestinal Diseases', 'Respiratory Tract Infections-identified-Acute Disease', 'Miller Fisher Syndrome-found-Gastrointestinal Diseases', 'Miller Fisher Syndrome-develop-Acute Disease', 'Gastrointestinal Diseases-identified-Acute Disease', 'Neoplasms-estimated-HIV Infections', 'Neoplasms-decrease-HIV Infections', 'Neoplasms-decrease-Sarcoma, Kaposi', 'Neoplasms-decrease-Lymphoma, Non-Hodgkin', 'Neoplasms-decrease-Lung Neoplasms', 'Neoplasms-decrease-Hodgkin Disease', 'Chronic Disease-face-Muscular Diseases', 'Renal Insufficiency, Chronic-exhibit-Cerebrovascular Disorders', 'Renal Insufficiency, Chronic-exhibit-Anemia', 'Renal Insufficiency, Chronic-exhibit-Hypertension', 'Renal Insufficiency, Chronic-exhibit-Diabetes Mellitus', 'Death-survive-Multiple Organ Failure', 'Xerostomia-associated-Mastocytosis, Systemic', 'Mastocytosis, Systemic-associated-Xerostomia', 'Mastocytosis, Systemic-concern-Xerostomia', 'Metabolic Diseases-observe-Polycystic Ovary Syndrome', 'Rheumatic Diseases-associated-Diverticulum', 'Diverticulum-associated-Rheumatic Diseases', 'Diverticulum-implicate-Hypertension', 'Diverticulum-implicate-Colonic Polyps', 'Neoplasms-present-Uterine Cervical Neoplasms', 'Neoplasms-prevent-Uterine Cervical Neoplasms', 'Dementia-exhibit-Memory Disorders', 'Dementia-exhibit-Sleep Wake Disorders', 'Death-added-Fractures, Bone', 'Death-added-Hip Fractures', 'Ankle Fractures-associated-Death', 'Death-associated-Ankle Fractures', 'Seizures-reviewed-Epilepsy', 'Epilepsy-interact-Seizures', 'Epilepsy-exposed-Seizures', 'HIV Infections-altered-Opportunistic Infections', 'Neoplasms-related-HIV Infections', 'Hypothalamic Neoplasms-seen-Thyroid Diseases', 'Adrenal Insufficiency-seen-Thyroid Diseases', 'Endocrine System Diseases-seen-HIV Infections', 'Endocrine System Diseases-include-Obesity', 'Endocrine System Diseases-include-Diabetes Mellitus', 'Endocrine System Diseases-include-Hyperlipidemias', 'Endocrine System Diseases-contribute-Lipodystrophy', 'Endocrine System Diseases-include-Death', 'Endocrine System Diseases-contribute-Death', 'HIV Infections-include-Obesity', 'HIV Infections-include-Diabetes Mellitus', 'HIV Infections-include-Hyperlipidemias', 'HIV Infections-contribute-Lipodystrophy', 'HIV Infections-include-Death', 'Coronary Artery Disease-associated-Multiple Organ Failure', 'Multiple Organ Failure-associated-Coronary Artery Disease', 'Coronary Artery Disease-present-Death', 'Diabetes Mellitus, Type 1-investigate-Diabetes Mellitus', 'Diabetes Mellitus, Type 1-investigate-Nervous System Diseases', 'Diabetes Mellitus, Type 1-investigate-Kidney Diseases', 'Neurodegenerative Diseases-tackle-Parkinson Disease', 'Hearing Loss-seem-Auditory Perceptual Disorders', 'Hearing Loss-affect-Peripheral Nervous System Diseases', 'Auditory Perceptual Disorders-associated-Peripheral Nervous System Diseases', 'Peripheral Nervous System Diseases-associated-Auditory Perceptual Disorders', 'Alzheimer Disease-considered-Atrophy', 'Leukoencephalopathies-manifest-Alzheimer Disease', 'Thrombosis-unprovoked-Venous Thromboembolism', 'Hypercapnia-lead-Psychophysiologic Disorders', 'Hypercapnia-occur-Pulmonary Disease, Chronic Obstructive', 'Hypercapnia-occur-Obesity Hypoventilation Syndrome', 'Hypercapnia-occur-Sleep Apnea, Obstructive', 'Hypercapnia-occur-Hypertension', 'Hypocapnia-start-Hypoxia', 'Hypercapnia-occur-Diabetes Mellitus', 'Hypocapnia-generate-Death', 'Hypercapnia-generate-Cardiovascular Diseases', 'Hypoxia-help-Death', 'Hypercapnia-occur-Immune System Diseases', 'Death-consider-Dementia', 'Dysuria-include-Infections', 'Pyuria-detect-Infections', 'Pyuria-found-Infections', 'Pyuria-found-Urinary Incontinence', 'Osteoarthritis-alter-Inflammation', 'Cardiovascular Abnormalities-associated-Pleural Effusion', 'Pleural Effusion-associated-Cardiovascular Abnormalities', 'Death-doubled-Multiple Trauma', 'Inflammation-underlie-Sarcopenia', 'Hypertension-cause-Heart Diseases', 'Lupus Erythematosus, Systemic-cause-Heart Diseases', 'Coronary Artery Disease-associated-Hypotension, Orthostatic', 'Hypotension, Orthostatic-associated-Coronary Artery Disease', 'Obesity, Abdominal-increase-Death', 'Sleep Apnea, Obstructive-develop-Delirium', 'Sleep Wake Disorders-develop-Delirium', 'Sleep Apnea, Obstructive-investigate-Delirium', 'Sleep Apnea, Obstructive-prevent-Delirium', 'Arbovirus Infections-increase-Death', 'Arbovirus Infections-associated-Hypertension', 'Hypertension-associated-Arbovirus Infections', 'Dermatomyositis-diagnose-Polymyositis', 'Stroke, Lacunar-include-Neurodegenerative Diseases', 'Neuromuscular Junction Diseases-contribute-Muscle Weakness', 'Inflammation-operate-Cardiovascular Diseases', 'Calcinosis-reveal-Endocarditis', 'Pericardial Effusion-reveal-Endocarditis', 'Calcinosis-lead-Pericardial Effusion', 'Sarcopenia-examine-Non-alcoholic Fatty Liver Disease', 'Hypercholesterolemia-associated-Stroke', 'Stroke-associated-Hypercholesterolemia', 'Hypercholesterolemia-associated-Death', 'Death-associated-Hypercholesterolemia', 'Mitochondrial Diseases-contribute-Metabolic Diseases', 'Mitochondrial Diseases-contribute-Neurodegenerative Diseases', 'Mitochondrial Diseases-contribute-Parkinson Disease', 'Inflammation-prevented-Hypothermia', 'Hypothermia-treat-Stroke', 'Hypothermia-reduce-Encephalitis', 'Stroke-reduce-Encephalitis', 'Cerebrovascular Disorders-defined-Brain Infarction', 'Carcinoma, Hepatocellular-increase-Arbovirus Infections', 'Kidney Diseases-range-Disease', 'Respiratory Insufficiency-followed-Cardiovascular Diseases', 'Respiratory Tract Diseases-follow-Dementia', 'Death-form-Pneumonia', 'Pneumonia-form-Neoplasms', 'Fractures, Bone-augment-Osteogenesis Imperfecta', 'Epstein-Barr Virus Infections-show-Hyperplasia', 'Cerebral Infarction-recognized-Stroke', 'Cerebral Infarction-lead-Dementia', 'Stroke-lead-Dementia', 'Cerebral Infarction-defined-Atrial Fibrillation', 'Hip Fractures-experience-Death', 'Hip Fractures-undertreated-Pain', 'Death-undertreated-Pain', 'Acute Pain-associated-Hip Fractures', 'Hip Fractures-associated-Acute Pain', 'Frailty-culminate-Death', 'Fractures, Bone-lead-Bone Marrow Failure Disorders', 'Diabetes Mellitus-seen-Obesity', 'Hypertension-classified-Hypertriglyceridemia', 'Kidney Diseases-identify-Nephrotic Syndrome', 'Osteoarthritis-focused-Pain', 'Osteoarthritis-supported-Teratoma', 'Neoplasms-associated-Infertility, Female', 'Infertility, Female-associated-Neoplasms', 'Ovarian Diseases-preserve-Neoplasms', 'Tremor-experienced-Parkinson Disease', 'Muscle Rigidity-experienced-Parkinson Disease', 'Shock, Septic-correlate-Death', 'Respiratory Tract Diseases-suffer-Malnutrition', 'Fractures, Bone-increase-Osteomyelitis', 'Osteomyelitis-deserve-Fractures, Bone', 'Chemical and Drug Induced Liver Injury-compare-Kidney Diseases', 'Death-suffer-Aortic Aneurysm', 'Fractures, Bone-show-Osteoarthritis', 'Kidney Diseases-defined-Hematuria', 'Fatigue-consist-Foot Ulcer', 'Fatigue-perform-Foot Ulcer', 'Tibial Meniscus Injuries-encountered-Infections', 'Hyperoxia-reduce-Postoperative Cognitive Complications', 'Death-compare-Spinal Cord Injuries', 'Status Epilepticus-reduce-Death', 'Status Epilepticus-associated-Vaginal Discharge', 'Vaginal Discharge-associated-Status Epilepticus', 'Status Epilepticus-range-Coma', 'Peritoneal Fibrosis-result-Pneumococcal Infections', 'Erythema-described-Erythrokeratodermia Variabilis', 'Erythema-underlie-Neoplasms', 'Erythrokeratodermia Variabilis-regarded-Paraneoplastic Syndromes', 'Erythema-regarded-Paraneoplastic Syndromes', 'Autoimmune Diseases-characterized-Erythema Nodosum', 'Erythema-appear-Skin Diseases', 'Diabetes Mellitus-considered-Disease', 'Diabetes Mellitus-assign-Ischemia', 'Disease-considered-Ischemia', 'Death-result-Acquired Immunodeficiency Syndrome', 'Acquired Immunodeficiency Syndrome-result-HIV Infections', 'Death-result-HIV Infections', 'Death-describe-HIV Infections', 'Death-diagnosed-HIV Infections', 'Death-use-HIV Infections', 'Urinary Incontinence-grouped-Urinary Bladder Neck Obstruction', 'Urinary Incontinence-grouped-Muscle Hypertonia', 'Urinary Incontinence-grouped-Urinary Bladder, Overactive', 'Urinary Incontinence-grouped-Urinary Tract Infections', 'Diabetes Mellitus-considered-Kidney Failure, Chronic', 'Inflammation-produced-Infections', 'Obesity-approaches-Diabetes Mellitus', 'Obesity-approaches-Kidney Diseases', 'Cerebral Amyloid Angiopathy-caused-Cerebral Hemorrhage', 'Brain Injuries-caused-Cerebral Hemorrhage', 'Pain-used-Low Back Pain', 'Pain-investigate-Low Back Pain', 'Hypotension-driven-Cardiac Output, Low', 'Myotonic Dystrophy-include-Neoplasms', 'Myotonic Dystrophy-include-Colorectal Neoplasms', 'Death-complete-Alzheimer Disease', 'Death-complete-Neurodegenerative Diseases', 'Metabolic Syndrome-increase-Neurodegenerative Diseases', 'Metabolic Syndrome-described-Neoplasms', 'Neurodegenerative Diseases-increase-Neoplasms', 'Inflammatory Bowel Diseases-associated-Abdominal Pain', 'Abdominal Pain-associated-Inflammatory Bowel Diseases', 'Pulmonary Disease, Chronic Obstructive-based-Signs and Symptoms, Respiratory', 'Pulmonary Disease, Chronic Obstructive-based-Airway Obstruction', 'Pain-recognise-Dementia', 'Neoplasms-use-Prostatic Neoplasms', 'Wolfram Syndrome-show-Diabetes Mellitus', 'Wolfram Syndrome-show-Optic Atrophy', 'Wolfram Syndrome-show-Deafness', 'Aging, Premature-show-Diabetes Mellitus', 'Aging, Premature-show-Optic Atrophy', 'Aging, Premature-show-Deafness', 'Osteoporosis-differentiate-Chronic Kidney Disease-Mineral and Bone Disorder', 'Osteoporosis-differentiate-Renal Insufficiency, Chronic', 'Communication Disorders-created-Hearing Disorders', 'Weight Loss-prevent-Osteoporosis', 'Delirium-associated-Epilepsy', 'Epilepsy-associated-Delirium', 'Delirium-associated-Parkinson Disease', 'Parkinson Disease-associated-Delirium', 'Delirium-associated-Fractures, Bone', 'Fractures, Bone-associated-Delirium', 'Diabetes Mellitus-live-Dementia', 'Ischemia-predispose-Death', 'Chronic Pain-defined-Back Pain', 'Heart Failure-represent-Graves Ophthalmopathy', 'Aneurysm-limit-Aortic Aneurysm, Abdominal', 'Carcinoma, Squamous Cell-extend-Neoplasms', 'Cough-conduct-Whooping Cough', 'Cough-conduct-Pneumonia', 'Infections-consider-Asthma', 'Asthma-consider-Pulmonary Disease, Chronic Obstructive', 'Arthritis, Rheumatoid-present-Joint Diseases', 'Asthma-recognized-Pulmonary Disease, Chronic Obstructive', 'Asthma-underlie-Primary Immunodeficiency Diseases', 'Respiratory Tract Infections-recognized-Pulmonary Disease, Chronic Obstructive', 'Respiratory Tract Infections-underlie-Primary Immunodeficiency Diseases', 'Pulmonary Disease, Chronic Obstructive-underlie-Primary Immunodeficiency Diseases', 'Substance-Related Disorders-used-Necrosis', 'Endometrial Neoplasms-distinguished-Ovarian Neoplasms', 'Corneal Diseases-affected-Wounds and Injuries', 'Ossification, Heterotopic-occur-Musculoskeletal Diseases', 'Ossification, Heterotopic-occur-Central Nervous System Diseases', 'Ossification, Heterotopic-occur-Joint Diseases', 'Ossification, Heterotopic-occur-Wounds and Injuries', 'Musculoskeletal Diseases-occur-Central Nervous System Diseases', 'Musculoskeletal Diseases-occur-Joint Diseases', 'Musculoskeletal Diseases-occur-Wounds and Injuries', 'Osteoarthritis-include-Neurodegenerative Diseases', 'Osteoarthritis-include-Pain', 'Spinal Stenosis-include-Neurodegenerative Diseases', 'Spinal Stenosis-include-Pain', 'Neurodegenerative Diseases-include-Pain', 'Diabetes Mellitus, Type 2-suffer-Dementia', 'Diabetes Mellitus, Type 2-suffer-Alzheimer Disease', 'Parkinson Disease-report-Heredodegenerative Disorders, Nervous System', 'Leukemia, Myeloid, Acute-reported-Neoplasms', 'Diabetes Mellitus-achieve-Carcinoma, Non-Small-Cell Lung', 'Neck Pain-associated-Death', 'Death-associated-Neck Pain', 'Ossification of Posterior Longitudinal Ligament-vary-Alzheimer Disease', 'Subarachnoid Hemorrhage-include-Brain Injuries, Traumatic', 'Hematoma, Epidural, Spinal-include-Brain Injuries, Traumatic', 'Neurodegenerative Diseases-affected-Genetic Diseases, Inborn', 'Neurodegenerative Diseases-affected-Cockayne Syndrome', 'Neurodegenerative Diseases-affected-Xeroderma Pigmentosum', 'Sleep Initiation and Maintenance Disorders-control-Urinary Incontinence', 'Metabolic Syndrome-include-Psychoses, Substance-Induced', 'Pulmonary Disease, Chronic Obstructive-result-Emphysema', 'Pulmonary Disease, Chronic Obstructive-introduce-Lung Diseases', 'Infections-develop-Peptic Ulcer', 'Infections-develop-Anemia, Iron-Deficiency', 'Infections-develop-Stomach Diseases', 'Infections-develop-Lymphoma, B-Cell, Marginal Zone', 'Infections-develop-Stomach Neoplasms', 'Glaucoma-describe-Alzheimer Disease', 'Glaucoma-considered-Neurodegenerative Diseases', 'Death-coupled-Fibrosis', 'Death-coupled-Cardiomyopathies', 'Fibrosis-culminate-Cardiomyopathies', 'Death-display-Heart Failure', 'Death-explained-Neoplasms', 'Inflammation-activated-Hyperglycemia', 'Delirium-recognized-Movement Disorders', 'Heart Diseases-lead-Hypertrophy', 'Heart Diseases-lead-Fibrosis', 'Death-link-Hip Fractures', 'Death-decrease-Kidney Diseases', 'Hemorrhage-increase-Kidney Diseases', 'Hypothyroidism-follow-Heart Diseases', 'Diabetes Mellitus, Type 2-follow-Heart Diseases', 'Brain Diseases-underlie-Learning Disabilities', 'Erectile Dysfunction-caused-Atherosclerosis', 'Atherosclerosis-manifest-Vascular System Injuries', 'Hallucinations-caused-Atherosclerosis', 'Cerebrovascular Disorders-caused-Atherosclerosis', 'Headache Disorders, Secondary-associated-Stroke', 'Stroke-associated-Headache Disorders, Secondary', 'Headache Disorders, Secondary-used-Dementia', 'Retinal Perforations-occur-Congenital Abnormalities', 'von Willebrand Diseases-prove-Aortic Valve Stenosis', 'Hematoma, Subdural-benefit-Hematoma', 'Pneumonia, Aspiration-follow-Neutropenia', 'Death-increase-Chagas Disease', 'Death-associated-Chagas Disease', 'Chagas Disease-associated-Death', 'Lung Diseases-recognized-Pulmonary Aspergillosis', 'Neurodegenerative Diseases-highlight-Glaucoma', 'Neoplasms-interact-Infections', 'Neurodegenerative Diseases-highlight-Alzheimer Disease', 'Fractures, Bone-increase-Wounds and Injuries', 'Inflammation-reduce-Alzheimer Disease', 'Dyslipidemias-investigate-Hearing Loss', 'Atrial Fibrillation-undergo-Coronary Artery Disease', 'Lithiasis-diagnosed-Neoplasms', 'Respiratory Distress Syndrome-associated-Autoimmune Diseases', 'Autoimmune Diseases-associated-Respiratory Distress Syndrome', 'Hyponatremia-caused-Inappropriate ADH Syndrome', 'Hyponatremia-avoid-Demyelinating Diseases', 'Death-found-Sexual Dysfunction, Physiological', 'Inflammation-control-Chronic Disease', 'Atrial Fibrillation-underlie-Arrhythmias, Cardiac', 'Neoplasm Metastasis-cause-Neoplasms', 'Death-found-Alzheimer Disease', 'Death-found-Kidney Failure, Chronic', 'Death-found-Cerebrovascular Disorders', 'Uterine Cervicitis-caused-Wounds and Injuries', 'Acute Disease-caused-Wounds and Injuries', 'Osteoporosis-manage-Diabetes Mellitus', 'Osteoporosis-ensure-Diabetes Mellitus', 'Diabetes Mellitus-underrepresent-Fractures, Bone', 'Chronic Disease-increase-Death', 'Inflammatory Bowel Diseases-experience-Neoplasms', 'Inflammation-contribute-Blindness', 'Lymphoma, Non-Hodgkin-observed-Inflammatory Bowel Diseases', 'Neoplasms-observed-Inflammatory Bowel Diseases', 'Breast Neoplasms-observed-Inflammatory Bowel Diseases', 'Neoplasms-prefer-Hemorrhage', 'Cardiovascular Diseases-thwart-Neoplasms', 'Osteoporosis-include-Fractures, Bone', 'Osteoporosis-accompanied-Fractures, Bone', 'Lupus Erythematosus, Systemic-use-Chronic Disease', 'Lupus Erythematosus, Systemic-use-Fatigue', 'Fatigue-influence-Lupus Erythematosus, Systemic', 'Thyroid Neoplasms-compare-Neoplasms', 'Inflammation-linked-Neoplasms', 'Inflammation-associated-Liver Diseases', 'Liver Diseases-associated-Inflammation', 'Inflammation-associated-Kidney Diseases', 'Kidney Diseases-associated-Inflammation', 'HIV Infections-interact-Drug-Related Side Effects and Adverse Reactions', 'HIV Infections-interact-Weight Gain', 'Alzheimer Disease-exclude-Dementia', 'Communicable Diseases-caused-Echinococcosis', 'Idiopathic Pulmonary Fibrosis-characterized-Death', 'Mitochondrial Diseases-contribute-Idiopathic Pulmonary Fibrosis', 'Carotid Stenosis-associated-Glaucoma', 'Glaucoma-associated-Carotid Stenosis', 'Obesity-pose-Infections', 'Infections-classified-Obesity', 'Hemophilia A-result-Hemorrhage', 'Hemophilia A-affected-Hemorrhage', 'Hemophilia A-represent-Neoplasms', 'Heredodegenerative Disorders, Nervous System-linked-Neoplasms', 'Dyslipidemias-decrease-Hypertension', 'Psoriasis-fuel-Inflammation', 'Atherosclerosis-increased-Arthritis, Rheumatoid', 'Atherosclerosis-predicted-HIV Infections', 'Kidney Diseases-define-Hypertension', 'Obesity-develop-Kidney Diseases', 'Neoplasms-function-Pain', 'Communicable Diseases-establish-Infections', 'Communicable Diseases-strengthen-Infections', 'Osteoporosis-live-HIV Infections', 'End Stage Liver Disease-live-HIV Infections', 'Chronic Disease-confer-Death', 'Sarcopenia-occur-Obesity', 'Heart Failure-improve-Sarcopenia', 'Heart Failure-make-Cachexia', 'Sarcopenia-suffer-Heart Failure', 'Anemia-aggravate-Chronic Disease', 'Kidney Failure, Chronic-diagnosed-Anemia', 'Kidney Failure, Chronic-show-Anemia', 'End Stage Liver Disease-show-Anemia', 'Hematologic Neoplasms-show-Anemia', 'Neoplasms-show-Anemia', 'Atrial Fibrillation-result-Stroke', 'Hepatitis C-prevent-Pancreatitis, Graft', 'Thromboembolism-result-Stroke', 'Drug-Related Side Effects and Adverse Reactions-lead-Mitochondrial Diseases', 'Drug-Related Side Effects and Adverse Reactions-accelerate-Neurodegenerative Diseases', 'Mitochondrial Diseases-accelerate-Neurodegenerative Diseases', 'Periodontal Attachment Loss-obtain-Periodontal Diseases', 'Epilepsies, Partial-diagnose-Gallstones', 'Sepsis-provide-Death', 'Sepsis-defined-Multiple Organ Failure', 'Sepsis-defined-Infections', 'Sepsis-caused-Infections', 'Multiple Organ Failure-caused-Infections', 'Death-described-Adrenal Insufficiency', 'Death-account-Sepsis', 'Sepsis-influence-Death', 'Sepsis-receive-Death', 'Onychomycosis-vary-Diabetes Mellitus', 'Alzheimer Disease-related-Death', 'Hypotension-indicate-Hypovolemia', 'Myelodysplastic Syndromes-include-Hypotension', 'Leukemia, Myeloid, Acute-include-Hypotension', 'Leukemia, Lymphocytic, Chronic, B-Cell-include-Hypotension', 'Multiple Myeloma-include-Hypotension', 'Neoplasms-show-Drug-Related Side Effects and Adverse Reactions', 'Stroke-experience-Hip Fractures', 'Death-show-Reperfusion Injury', 'Pulmonary Disease, Chronic Obstructive-associated-Emphysema', 'Emphysema-associated-Pulmonary Disease, Chronic Obstructive', 'Pulmonary Disease, Chronic Obstructive-determine-Death', 'Pulmonary Disease, Chronic Obstructive-determine-HIV Infections', 'Respiratory Tract Infections-implicated-Pneumonia', 'Respiratory Tract Infections-implicated-Death', 'Respiratory Tract Infections-implicated-Infections', 'Diabetes Mellitus-remain-Cardiovascular Diseases', 'Osteoarthritis-give-Joint Diseases', 'Cartilage Diseases-considered-Osteoarthritis', 'Coronary Artery Disease-include-Stroke', 'Hypertrophy, Left Ventricular-include-Atrial Fibrillation', 'Hypertrophy, Left Ventricular-include-Stroke', 'Heart Valve Diseases-include-Atrial Fibrillation', 'Heart Valve Diseases-include-Stroke', 'Stroke-include-Arrhythmias, Cardiac', 'Renal Insufficiency-include-Arrhythmias, Cardiac', 'Communicable Diseases-associated-Hypertension', 'Hypertension-associated-Communicable Diseases', 'Communicable Diseases-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-Communicable Diseases', 'Hypotension, Orthostatic-known-Acute Disease', 'Heart Failure, Diastolic-triggered-Inflammation', 'Signs and Symptoms, Respiratory-associated-Respiratory Tract Infections', 'Respiratory Tract Infections-associated-Signs and Symptoms, Respiratory', 'Neoplasms-present-Thyroid Neoplasms', 'Neoplasms-present-Neoplasm Metastasis', 'Diabetes Mellitus-live-HIV Infections', 'Hypercholesterolemia-live-HIV Infections', 'Lung Neoplasms-discussed-Neoplasms', 'Arthritis, Rheumatoid-lead-Synovitis', 'Arthritis, Rheumatoid-lead-Inflammation', 'Arthritis, Rheumatoid-present-Arthritis, Juvenile', 'Synovitis-affect-Joint Diseases', 'Wounds and Injuries-include-Sleep Wake Disorders', 'Pain, Postoperative-include-Sleep Wake Disorders', 'Hepatitis C-prevent-Infections', 'Pain-assess-Musculoskeletal Pain', 'Cardiovascular Diseases-include-Communicable Diseases', 'Fractures, Bone-assessed-Osteoporosis', 'Atherosclerosis-explain-Cardiovascular Diseases', 'Inflammation-explain-Cardiovascular Diseases', 'Neurologic Manifestations-lead-Neurodegenerative Diseases', 'Neurologic Manifestations-lead-Neoplasms', 'Hypotension, Orthostatic-associated-Vision Disorders', 'Vision Disorders-associated-Hypotension, Orthostatic', 'Hip Fractures-associated-Muscle Weakness', 'Muscle Weakness-associated-Hip Fractures', 'Death-associated-Pericarditis', 'Pericarditis-associated-Death', 'Fractures, Bone-affect-Multiple Myeloma', 'Heart Failure-occur-Fractures, Bone', 'Heart Failure-occur-Dental Caries', 'Sleep Initiation and Maintenance Disorders-considered-Alzheimer Disease', 'Arrhythmias, Cardiac-decrease-Alzheimer Disease', 'Arthritis, Rheumatoid-review-Inflammation', 'Calcinosis-used-Intracranial Arteriosclerosis', 'Delirium-estimate-Death', 'Death-appear-Delirium', 'Sleep Wake Disorders-link-Dementia', 'Death-decrease-Pneumonia', 'Lung Neoplasms-compare-Idiopathic Pulmonary Fibrosis', 'Pain-develop-Idiopathic Pulmonary Fibrosis', 'Infections-regard-Diabetes Mellitus', 'Infections-regard-Neoplasms', 'Hematoma, Subdural, Acute-establish-Seizures', 'Spinal Cord Injuries-occur-Brain Injuries, Traumatic', 'Muscle Weakness-followed-Myalgia', 'Muscle Weakness-followed-Myotonia', 'Muscle Weakness-associated-Myalgia', 'Myalgia-associated-Muscle Weakness', 'Diabetes Mellitus-diagnosed-Pain', 'Immunologic Deficiency Syndromes-aggravate-Nerve Degeneration', 'Immunologic Deficiency Syndromes-associated-Neurodegenerative Diseases', 'Neurodegenerative Diseases-associated-Immunologic Deficiency Syndromes', 'Neurodegenerative Diseases-help-Parkinson Disease', 'Parkinson Disease-suffer-Fatigue', 'Parkinson Disease-address-Sleep Wake Disorders', 'Williams Syndrome-characterized-Chromosome Aberrations', 'Hepatitis C-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-Hepatitis C', 'Infections-involved-Autoimmune Diseases', 'Infections-involved-Multiple Sclerosis', 'Dysbiosis-associated-Multiple Sclerosis', 'Multiple Sclerosis-associated-Dysbiosis', 'Dysbiosis-derived-Multiple Sclerosis', 'Dysbiosis-trigger-Ataxia Telangiectasia', 'Death-identify-Sclerosis', 'Death-identify-Cerebral Infarction', 'Hematoma, Subdural, Chronic-occur-Thrombosis', 'Inflammation-missed-Tuberculosis', 'Epilepsy-associated-Hematoma, Subdural, Chronic', 'Hematoma, Subdural, Chronic-associated-Epilepsy', 'Seroma-include-Hernia', 'Seizures-prevent-Hematoma, Subdural, Chronic', 'Cardiovascular Diseases-exert-Death', 'Heart Failure-exert-Death', 'Asthma-increase-Rhinitis', 'Memory Disorders-use-Dementia', 'Memory Disorders-associated-Parkinson Disease', 'Parkinson Disease-associated-Memory Disorders', 'Genetic Diseases, X-Linked-cause-Muscle Weakness', 'Blood Loss, Surgical-defined-Hemorrhage', 'Musculoskeletal Diseases-observed-Pain', 'Diabetes Mellitus, Type 2-increase-Death', 'Hip Fractures-experience-Fractures, Bone', 'Hypertension-increase-Atherosclerosis', 'Mucopolysaccharidosis III-identified-Pneumonia', 'Mucopolysaccharidosis III-identified-Death', 'Respiratory Tract Infections-remain-Death', 'Pneumonia-identified-Death', 'Respiratory Tract Infections-remain-Mucopolysaccharidosis III', 'Pneumonia-remain-Mucopolysaccharidosis III', 'Delirium-compare-Hip Fractures', 'Cardiovascular Diseases-reduce-Fatigue', 'Atrophy-characterized-Parkinson Disease, Secondary', 'Atrophy-characterized-Primary Dysautonomias', 'Atrophy-characterized-Ataxia', 'Synucleinopathies-characterized-Parkinson Disease, Secondary', 'Synucleinopathies-characterized-Primary Dysautonomias', 'Vitiligo-surround-Pigmentation Disorders', 'Synucleinopathies-characterized-Ataxia', 'Cerebral Hemorrhage-form-Subdural Effusion', 'Hydrocephalus-lessened-Subdural Effusion', 'Subdural Effusion-stopped-Hydrocephalus', 'Infections-promote-Gastritis', 'Idiopathic Pulmonary Fibrosis-reflect-Cumulative Trauma Disorders', 'Renal Insufficiency, Chronic-represent-Arteriosclerosis', 'Renal Insufficiency, Chronic-represent-Vascular Calcification', 'Renal Insufficiency, Chronic-represent-Bone Diseases', 'Atrial Fibrillation-include-Atrial Remodeling', 'Atrial Fibrillation-addressed-Atrial Remodeling', 'Glycogen Storage Disease Type II-found-Muscular Disorders, Atrophic', 'Atrioventricular Block-evaluate-Muscular Dystrophy, Duchenne', 'Death-note-Renal Insufficiency, Chronic', 'Death-decrease-Colorectal Neoplasms', 'Death-decrease-Neoplasms', 'Death-decrease-Nephrotic Syndrome', 'Neoplasms-avoid-Bone Neoplasms', 'Neoplasms-considered-Ocular Hypertension', 'Atrial Fibrillation-considered-Arrhythmias, Cardiac', 'Atrial Fibrillation-preferred-Stroke', 'Arrhythmias, Cardiac-preferred-Stroke', 'Atrial Fibrillation-understood-Adrenal Insufficiency', 'Fibrosis-accompany-Heart Failure', 'Anemia-include-Cerebrovascular Disorders', 'Metabolic Diseases-measured-Foot Ulcer', 'Obesity-act-Coronary Artery Disease', 'Sarcopenia-investigate-Intestinal Diseases', 'Alcoholism-identified-Sarcopenia', 'Intestinal Diseases-identified-Sarcopenia', 'Arbovirus Infections-increase-Neoplasms', 'Arbovirus Infections-increase-Autoimmune Diseases', 'Autoimmune Diseases-increase-Death', 'Headache-reported-Dementia', 'Tauopathies-include-Neurodegenerative Diseases', 'Fragile X Syndrome-lead-Pneumonia', 'Infections-account-Severe Acute Respiratory Syndrome', 'Infections-account-Death', 'Dementia-increased-Leukoencephalopathies', 'Cardiovascular Diseases-lost-Death', 'Coronary Artery Disease-lost-Death', 'Diabetes Mellitus-detect-Anophthalmos', 'Polymyalgia Rheumatica-associated-Giant Cell Arteritis', 'Giant Cell Arteritis-associated-Polymyalgia Rheumatica', 'Fibrosis-define-Ovarian Diseases', 'Fibrosis-conducted-Liver Diseases', 'Neoplasms-increase-Thrombosis', 'Gallstones-revised-Death', 'Infarction-associated-Overbite', 'Overbite-associated-Infarction', 'Overbite-associated-Alzheimer Disease', 'Alzheimer Disease-associated-Overbite', 'Hypertension-drive-Cerebral Amyloid Angiopathy', 'Urinary Bladder Neck Obstruction-caused-Prostatitis', 'Hyperplasia-show-Prostatic Neoplasms', 'Death-grow-Acquired Immunodeficiency Syndrome', 'Death-associated-Lymphoma, Non-Hodgkin', 'Lymphoma, Non-Hodgkin-associated-Death', 'Fatigue-followed-Diarrhea', 'Fatigue-followed-Constipation', 'Death-examine-Cardiovascular Diseases', 'Sarcopenia-determined-Ataxia', 'Sarcopenia-develop-Urinary Incontinence', 'Wounds and Injuries-associate-Sleep Wake Disorders', 'Sleep Wake Disorders-associate-Wounds and Injuries', 'Critical Illness-include-Chronic Disease', 'Obesity-position-Metabolic Syndrome', 'Seizures-meet-Obesity', 'Seizures-meet-Metabolic Syndrome', 'Aneurysm-become-Death', 'Acute Coronary Syndrome-include-Angina, Unstable', 'Angina Pectoris-defined-Ischemia', 'Angina Pectoris-defined-Necrosis', 'Ischemia-defined-Necrosis', 'Plaque, Atherosclerotic-result-Necrosis', 'Kidney Diseases-show-Death', 'Death-calculated-Diabetes Mellitus', 'Diabetes Mellitus-calculated-Death', 'Plasmablastic Lymphoma-seen-Autoimmune Diseases', 'Lymphoma, Non-Hodgkin-seen-Autoimmune Diseases', 'Diabetic Nephropathies-imply-Diabetes Mellitus', 'Diabetes Mellitus-imply-Kidney Diseases', 'Diabetes Mellitus-imply-Kidney Failure, Chronic', 'Obesity-precede-Diabetes Mellitus', 'Denys-Drash Syndrome-precede-Diabetes Mellitus', 'Diabetes Mellitus-promote-Kidney Diseases', 'Diabetes Mellitus-cause-Proteinuria', 'Diabetes Mellitus-promote-Hypertrophy', 'Kidney Diseases-cause-Proteinuria', 'Diabetic Nephropathies-performed-Renal Insufficiency, Chronic', 'Hypertrophy-cause-Proteinuria', 'Hypertrophy-lead-Glomerulonephritis', 'Hypertrophy-lead-Denys-Drash Syndrome', 'Hypertension-identified-Colorectal Neoplasms', 'Hypogonadism-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-Hypogonadism', 'Pulmonary Disease, Chronic Obstructive-undergo-Tricuspid Valve Insufficiency', 'Pneumonia-followed-Respiratory Distress Syndrome', 'Brain Diseases, Metabolic-considered-Dystonia', 'Brain Diseases, Metabolic-considered-Seizures', 'Brain Diseases, Metabolic-considered-Nervous System Diseases', 'Hemolytic-Uremic Syndrome-considered-Dystonia', 'Hemolytic-Uremic Syndrome-considered-Seizures', 'Hemolytic-Uremic Syndrome-considered-Nervous System Diseases', 'Pseudotumor Cerebri-associated-Sinus Thrombosis, Intracranial', 'Sinus Thrombosis, Intracranial-associated-Pseudotumor Cerebri', 'Coronary Restenosis-demonstrate-Papilledema', 'Neurodegenerative Diseases-drive-Dementia', 'Neurodegenerative Diseases-drive-Alzheimer Disease', 'Neurodegenerative Diseases-drive-Epilepsy', 'Obesity, Abdominal-result-Hypertension', 'Obesity, Abdominal-result-Cardiovascular Diseases', 'Proteostasis Deficiencies-become-Idiopathic Pulmonary Fibrosis', 'Idiopathic Pulmonary Fibrosis-become-Mitochondrial Diseases', 'Weight Gain-contribute-Neoplasms', 'Weight Gain-contribute-Arthritis', 'Weight Gain-contribute-Sexual Dysfunction, Physiological', 'Acute Pain-reported-Osteoporosis', 'Pain-reported-Osteoporosis', 'Osteoporosis-reported-Back Pain', 'Osteoporosis-remain-Pain', 'Pain-linked-Osteoporosis', 'Hematologic Neoplasms-result-Bone Marrow Failure Disorders', 'Fractures, Bone-observed-Osteoporotic Fractures', 'Wounds and Injuries-suffer-Fractures, Bone', 'Tauopathies-associated-Alzheimer Disease', 'Alzheimer Disease-associated-Tauopathies', 'Neoplasms-rank-Death', 'Hemorrhage-include-Hereditary Breast and Ovarian Cancer Syndrome', 'Peripheral Nervous System Diseases-identify-Polyneuropathies', 'Inflammation-involved-Rosacea', 'Nervous System Diseases-identify-Polyneuropathies', 'Inflammation-involved-Renal Insufficiency, Chronic', 'Alzheimer Disease-measured-Neurodegenerative Diseases', 'Alzheimer Disease-composed-Neurodegenerative Diseases', 'Metabolic Syndrome-identify-Polyneuropathies', 'Death-remain-Rosacea', 'Rosacea-remain-Renal Insufficiency, Chronic', 'Euthyroid Sick Syndromes-named-Thyroid Diseases', 'Renal Insufficiency, Chronic-included-Rosacea', 'Rosacea-increase-Renal Insufficiency, Chronic', 'Hemostatic Disorders-include-Delirium', 'Coronary Artery Disease-include-Neoplasm Invasiveness', 'Hematologic Neoplasms-include-Neoplasm Invasiveness', 'Thrombocytopenia-represent-Myelodysplastic Syndromes', 'Cerebral Small Vessel Diseases-rely-Cerebral Infarction', 'Cerebral Small Vessel Diseases-rely-Stroke', 'Cerebral Infarction-remain-Cerebral Small Vessel Diseases', 'Fibrosis-result-Hypotension', 'Mitochondrial Diseases-promote-Osteoarthritis', 'Death-accord-Immunologic Deficiency Syndromes', 'Inflammation-play-Osteoarthritis', 'Death-related-Immunologic Deficiency Syndromes', 'Infections-followed-Neoplasms', 'Hyponatremia-seen-Renal Insufficiency, Chronic', 'Hyponatremia-seen-Hypothyroidism', 'Tuberculosis-comprise-Infections', 'Hyponatremia-lead-Brain Edema', 'Hyponatremia-lead-Brain Damage, Chronic', 'Hyponatremia-lead-Coma', 'HIV Infections-evolving-Opportunistic Infections', 'HIV Infections-prevent-Opportunistic Infections', 'HIV Infections-treat-Acquired Immunodeficiency Syndrome', 'Opportunistic Infections-treat-Acquired Immunodeficiency Syndrome', 'Diabetes Mellitus-associated-Carcinoma, Hepatocellular', 'Carcinoma, Hepatocellular-associated-Diabetes Mellitus', 'Dementia-arise-Pain', 'Sepsis-caused-Respiratory Tract Infections', 'Bacterial Infections-cause-Sepsis', 'Pain-caused-Scabies', 'Inflammation-compare-Asthma', 'Bronchial Diseases-compare-Asthma', 'Aneurysm-prevent-Death', 'Atrial Remodeling-associated-Atrial Fibrillation', 'Atrial Fibrillation-associated-Atrial Remodeling', 'Asthma-show-Airway Obstruction', 'Atherosclerosis-include-Atrial Fibrillation', 'Atherosclerosis-study-Atrial Fibrillation', 'Dementia-associated-Colorectal Neoplasms', 'Colorectal Neoplasms-associated-Dementia', 'Dementia-associate-Colorectal Neoplasms', 'Colorectal Neoplasms-associate-Dementia', 'Dementia-preexist-Colorectal Neoplasms', 'Dementia-associate-Neoplasms', 'Neoplasms-associate-Dementia', 'Dementia-preexist-Neoplasms', 'Fractures, Bone-discuss-Diabetes Mellitus', 'Sarcopenia-impair-Carcinoma, Hepatocellular', 'Carcinoma, Hepatocellular-identify-Sarcopenia', 'Vascular Calcification-occur-Diabetes Mellitus', 'Vascular Calcification-occur-Kidney Failure, Chronic', 'Death-divided-Diabetes Mellitus', 'Tuberculosis-detect-Death', 'Cardiovascular Diseases-suffer-Progeria', 'Tuberculosis-treat-Diabetes Mellitus', 'Cardiovascular Diseases-suffer-Genetic Diseases, Inborn', 'Brain Edema-see-Coma', 'Atrial Fibrillation-affect-Death', 'Arteriolosclerosis-account-Parkinson Disease, Secondary', 'Parkinson Disease, Secondary-account-Arteriolosclerosis', 'Parkinson Disease, Secondary-control-Cerebrovascular Disorders', 'Sarcopenia-share-Fractures, Bone', 'Sarcopenia-share-Osteoporosis', 'Sarcopenia-share-Obesity', 'Obesity-include-Fractures, Bone', 'Arteriolosclerosis-associated-Pallor', 'Pallor-associated-Arteriolosclerosis', 'Meningitis-include-Nervous System Diseases', 'Encephalitis-include-Nervous System Diseases', 'Tetany-include-Nervous System Diseases', 'Epilepsy-include-Nervous System Diseases', 'Motor Neuron Disease-include-Nervous System Diseases', 'Migraine Disorders-include-Nervous System Diseases', 'Headache-include-Nervous System Diseases', 'Headache Disorders, Secondary-include-Nervous System Diseases', 'Hypertension-contribute-Cardiovascular Infections', 'Atrial Fibrillation-require-Heart Failure', 'Atrial Fibrillation-require-Diabetes Mellitus', 'Infections-associate-Fractures, Bone', 'Fractures, Bone-associate-Infections', 'Bacteremia-related-Death', 'Delirium-identify-Dementia', 'HIV Infections-recognize-Infections', 'Metabolic Syndrome-associated-Prostatic Neoplasms', 'Prostatic Neoplasms-associated-Metabolic Syndrome', 'Chronic Disease-provide-Death', 'Fractures, Stress-stabilize-Fractures, Bone', 'Hemolytic-Uremic Syndrome-decrease-Death', 'Death-inform-HIV Infections', 'Death-inform-Acquired Immunodeficiency Syndrome', 'Myocardial Infarction-caused-Coronary Artery Disease', 'Myocardial Infarction-caused-Coronary Occlusion', 'Delirium-associated-Sarcopenia', 'Sarcopenia-associated-Delirium', 'Osteoporotic Fractures-use-Weight Loss', 'Osteoporotic Fractures-use-Sleep Initiation and Maintenance Disorders', 'Catheter-Related Infections-include-Obesity', 'Thyroid Diseases-gain-Cardiovascular Diseases', 'Thyroid Diseases-gain-Atrial Fibrillation', 'Renal Tubular Transport, Inborn Errors-determine-Necrosis', 'Reperfusion Injury-associated-Necrosis', 'Necrosis-associated-Reperfusion Injury', 'Infarction, Middle Cerebral Artery-receive-Stroke', 'Ichthyosis, X-Linked-screen-Hyponatremia', 'Hypopituitarism-present-Hyponatremia', 'Hyponatremia-divided-Hypopituitarism', 'Hyponatremia-divided-Intracranial Aneurysm', 'Hyponatremia-divided-Autoimmune Hypophysitis', 'Hyponatremia-divided-Brain Injuries, Traumatic', 'Hyponatremia-divided-Astrocytoma', 'Hyponatremia-divided-Bronchial Neoplasms', 'Endocrine Gland Neoplasms-identified-Hyponatremia', 'Endocrine Gland Neoplasms-identified-Hypopituitarism', 'Parkinson Disease-associated-Gait Ataxia', 'Gait Ataxia-associated-Parkinson Disease', 'Femoral Neck Fractures-compare-Fractures, Bone', 'Hyperalgesia-characterize-Brain Injuries, Traumatic', 'Hyperalgesia-develop-Edema', 'Brain Injuries, Traumatic-develop-Edema', 'Liver Failure, Acute-evolve-Fibrosis', 'Hypoglycemia-reported-Immunologic Deficiency Syndromes', 'Mitochondrial Diseases-lead-Brain Diseases, Metabolic', 'Drug-Related Side Effects and Adverse Reactions-cause-Liver Diseases', 'Metabolic Syndrome-cause-Liver Diseases', 'Mitochondrial Diseases-cause-Liver Diseases', 'Sleep Initiation and Maintenance Disorders-include-Cardiac Output, Low', 'Long QT Syndrome-arise-Arrhythmias, Cardiac', 'Heart Arrest-include-Fibrosis', 'Heart Arrest-contribute-Fibrosis', 'Hemolytic-Uremic Syndrome-accumulated-Kidney Diseases', 'Hemolytic-Uremic Syndrome-cause-Kidney Diseases', 'Hemolytic-Uremic Syndrome-lead-Acute Kidney Injury', 'Kidney Diseases-lead-Acute Kidney Injury', 'Renal Insufficiency, Chronic-characterized-Kidney Diseases', 'Renal Insufficiency, Chronic-characterized-Fibrosis', 'Renal Tubular Transport, Inborn Errors-involved-Renal Insufficiency, Chronic', 'Drug-Related Side Effects and Adverse Reactions-accelerate-Renal Insufficiency, Chronic', 'Periodontitis-considered-Infections', 'Periodontitis-considered-Osteoporosis', 'Periodontitis-develop-Osteoporosis', 'Osteoporosis-increase-Diabetes Mellitus', 'Osteoporosis-increase-Periodontitis', 'Cardiovascular Diseases-become-Infections', 'Cardiovascular Diseases-live-Infections', 'HIV Infections-characterized-Cardiovascular Diseases', 'Bone Diseases-characterized-Fractures, Bone', 'Urinary Bladder, Overactive-improve-Breast Neoplasms', 'Hearing Loss-followed-Hearing Loss, Central', 'Wounds and Injuries-occur-Fractures, Bone', 'Glucose Metabolism Disorders-contribute-Inflammation', 'Glucose Metabolism Disorders-contribute-Neoplasms', 'Mitochondrial Diseases-delay-Intervertebral Disc Degeneration', 'Diabetes Mellitus-impair-Neoplasms', 'Diabetes Mellitus-impair-Alzheimer Disease', 'Bone Diseases-increase-Fractures, Stress', 'Diabetes Mellitus-associated-Surgical Wound Infection', 'Surgical Wound Infection-associated-Diabetes Mellitus', 'Carcinoma, Squamous Cell-associated-Surgical Wound Infection', 'Surgical Wound Infection-associated-Carcinoma, Squamous Cell', 'Lung Diseases-associated-Surgical Wound Infection', 'Surgical Wound Infection-associated-Lung Diseases', 'Menopause, Premature-suggested-Myalgia', 'Renal Insufficiency, Chronic-base-Kidney Diseases', 'Adenoma-associated-Hemorrhage', 'Hemorrhage-associated-Adenoma', 'Hypertension-correlate-Renal Insufficiency, Chronic', 'Diabetes Mellitus-correlate-Renal Insufficiency, Chronic', 'Cardiovascular Diseases-correlate-Renal Insufficiency, Chronic', 'Malocclusion-associated-Sepsis', 'Sepsis-associated-Malocclusion', 'Hypoalbuminemia-yield-Death', 'Thrombocytopenia-yield-Death', 'Nephritis-exhibit-Proteinuria', 'Alzheimer Disease-elicit-Neurodegenerative Diseases', 'Gout-treat-Kidney Diseases', 'Prostatic Neoplasms-expected-Colorectal Neoplasms', 'Myelodysplastic Syndromes-characterize-Anemia', 'Myelodysplastic Syndromes-characterize-Hematologic Diseases', 'Hematologic Neoplasms-characterize-Anemia', 'Hematologic Neoplasms-characterize-Hematologic Diseases', 'Heart Defects, Congenital-associated-Atrioventricular Block', 'Atrioventricular Block-associated-Heart Defects, Congenital', 'Arthritis, Rheumatoid-suffer-Joint Diseases', 'von Willebrand Diseases-present-Hemophilia A', 'Hemorrhage-reduced-von Willebrand Diseases', 'Death-attributed-Colorectal Neoplasms', 'Myocardial Infarction-increase-Diabetes Mellitus', 'Neoplasm Metastasis-originate-Neoplasms', 'Neoplasm Metastasis-treated-Neoplasms', 'Coagulation Protein Disorders-lead-Hemorrhage', 'Death-cause-Chronic Disease', 'Jaw, Edentulous-identified-Periodontitis', 'Jaw, Edentulous-identified-Inflammation', 'Periodontitis-identified-Inflammation', 'Fibrosis-include-Communicable Diseases', 'Parasitemia-include-Malaria', 'Microvascular Angina-include-Malaria', 'Malaria, Falciparum-increase-Parasitic Diseases', 'Malaria, Falciparum-include-Malaria', 'Heart Failure-underlie-HIV Infections', 'Muscular Disorders, Atrophic-target-Choroidal Neovascularization', 'Dry Eye Syndromes-defined-Xerostomia', 'Infections-include-Bronchiolitis', 'Death-seen-Atrial Fibrillation', 'Heart Failure-defined-Sensation Disorders', 'Diabetes Mellitus-contribute-Cryptococcosis', 'Huntington Disease-show-Atrophy', 'Huntington Disease-found-Parkinson Disease', 'Atrophy-found-Parkinson Disease', 'Pain-associated-Fractures, Open', 'Fractures, Open-associated-Pain', 'Dyslipidemias-associated-Sarcopenia', 'Sarcopenia-associated-Dyslipidemias', 'Diabetes Mellitus-predict-Sarcopenia', 'Hypertension-predict-Sarcopenia', 'Glomerulonephritis-caused-Scabies', 'Glomerulonephritis-present-Exanthema', 'Scabies-result-Bacterial Infections', 'Glomerulonephritis-present-Asthma', 'Scabies-result-Glomerulonephritis', 'Scabies-lead-Glomerulonephritis', 'Glomerulonephritis-present-Hematuria', 'Bacterial Infections-lead-Glomerulonephritis', 'Glomerulonephritis-present-Proteinuria', 'Glomerulonephritis-present-Hypertension', 'Glomerulonephritis-present-Azotemia', 'Scabies-present-Exanthema', 'Scabies-present-Asthma', 'Scabies-present-Hematuria', 'Scabies-present-Proteinuria', 'Scabies-present-Hypertension', 'Atrial Fibrillation-decrease-Stroke', 'Scabies-present-Azotemia', 'Osteoporosis-sustain-Fractures, Bone', 'Thyroid Diseases-associated-Dementia', 'Dementia-associated-Thyroid Diseases', 'Sleep Wake Disorders-reflect-Hypoxia', 'Anemia-classified-Thalassemia', 'Gaucher Disease-cause-Parkinson Disease', 'Heart Failure-optimize-Renal Insufficiency, Chronic', 'Infections-associated-Osteomyelitis', 'Osteomyelitis-associated-Infections', 'Drug-Related Side Effects and Adverse Reactions-range-Bone Marrow Diseases', 'Fractures, Bone-identified-Malocclusion', 'Heart Failure-found-Myocardial Infarction', 'Cerebral Amyloid Angiopathy-treated-Alzheimer Disease', 'Cerebral Amyloid Angiopathy-associated-Vascular System Injuries', 'Vascular System Injuries-associated-Cerebral Amyloid Angiopathy', 'Heart Failure-include-Dyspnea', 'Heart Failure-include-Fatigue', 'Cerebral Amyloid Angiopathy-start-Cerebral Hemorrhage', 'Eye Abnormalities-detected-Vision Disorders', 'Eye Abnormalities-detected-Keratoconjunctivitis', 'Eye Abnormalities-detected-Cataract', 'Eye Abnormalities-detected-Glaucoma', 'Eye Abnormalities-detected-Hypertension', 'Eye Abnormalities-detected-Atherosclerosis', 'Vasospasm, Intracranial-seen-Hydrocephalus', 'Periodontitis-link-Arthritis, Rheumatoid', 'Arthritis, Rheumatoid-involve-Inflammation', 'Periodontitis-involve-Inflammation', 'Hematologic Neoplasms-include-Leukemia, Myeloid, Acute', 'Hematologic Neoplasms-include-Multiple Myeloma', 'Hematologic Neoplasms-include-Myelodysplastic Syndromes', 'Hematologic Neoplasms-include-Leukemia, Lymphoid', 'Hematologic Neoplasms-include-Precursor Cell Lymphoblastic Leukemia-Lymphoma', 'von Willebrand Diseases-include-Gastrointestinal Hemorrhage', 'Angiodysplasia-include-Gastrointestinal Hemorrhage', 'Arteriovenous Malformations-include-Gastrointestinal Hemorrhage', 'Rupture-related-Aortic Aneurysm, Abdominal', 'Rupture-prevent-Aortic Aneurysm, Abdominal', 'Sarcopenia-predict-Stomach Neoplasms', 'Lysosomal Storage Diseases-documented-Neurodegenerative Diseases', 'Lysosomal Storage Diseases-documented-Alzheimer Disease', 'Neurodegenerative Diseases-documented-Alzheimer Disease', 'Fanconi Anemia-feature-Neoplasms', 'Fanconi Anemia-feature-Congenital, Hereditary, and Neonatal Diseases and Abnormalities', 'Death-examine-Wounds and Injuries', 'Genetic Diseases, Inborn-feature-Neoplasms', 'Wounds and Injuries-use-Death', 'Genetic Diseases, Inborn-feature-Congenital, Hereditary, and Neonatal Diseases and Abnormalities', "Corneal Diseases-lead-Fuchs' Endothelial Dystrophy", 'Corneal Diseases-lead-Wounds and Injuries', "Fuchs' Endothelial Dystrophy-lead-Corneal Edema", "Fuchs' Endothelial Dystrophy-lead-Blindness", 'Wounds and Injuries-lead-Corneal Edema', 'Wounds and Injuries-lead-Blindness', 'Hypogonadism-treat-Cardiovascular Diseases', 'Sleep Apnea Syndromes-associated-Communicable Diseases', 'Communicable Diseases-associated-Sleep Apnea Syndromes', 'Pulmonary Disease, Chronic Obstructive-use-Asthma', 'Asthma-attributed-Pulmonary Disease, Chronic Obstructive', 'Pulmonary Disease, Chronic Obstructive-cause-Asthma', 'Death-take-Sarcopenia', 'Fractures, Bone-include-Mucopolysaccharidosis II', 'Neoplasms-associated-Vascular System Injuries', 'Vascular System Injuries-associated-Neoplasms', 'Mesothelioma-acquired-Neoplasms', 'Osteoporotic Fractures-increase-Pain', 'Osteoporotic Fractures-increased-Death', 'Fractures, Bone-increase-Pain', 'Fractures, Bone-increased-Death', 'Fractures, Bone-lead-Neurologic Manifestations', 'Fractures, Bone-lead-Kyphosis', 'Dementia-corroborate-Vision Disorders', 'Fractures, Bone-develop-Kyphosis', 'Fractures, Bone-develop-Neurologic Manifestations', 'Retinal Degeneration-characterized-Inflammation', 'Mitochondrial Diseases-involved-Parkinson Disease', 'Kidney Diseases-decrease-Acute Kidney Injury', 'Conjunctival Diseases-result-Photophobia', 'Conjunctival Diseases-result-Vision Disorders', 'Neuromyelitis Optica-present-Leukoencephalopathies', 'Progeria-fabricated-Calcinosis', 'Hemorrhagic Disorders-associated-Progeria', 'Progeria-associated-Hemorrhagic Disorders', 'Weight Loss-show-Obesity', 'Osteoarthritis-documented-Death', 'Mandibular Nerve Injuries-represent-Lupus Vasculitis, Central Nervous System', 'Pneumococcal Infections-need-Infections', 'Retinal Degeneration-caused-Blood Protein Disorders', 'Neoplasms-harbor-Leukemia', 'Abnormalities, Drug-Induced-include-Edema', 'Abnormalities, Drug-Induced-confirmed-Edema', 'Abnormalities, Drug-Induced-include-Neoplastic Cells, Circulating', 'Abnormalities, Drug-Induced-confirmed-Neoplastic Cells, Circulating', 'Abnormalities, Drug-Induced-include-Venous Thrombosis', 'Abnormalities, Drug-Induced-confirmed-Venous Thrombosis', 'Bradycardia-include-Renal Tubular Transport, Inborn Errors', 'Cardiac Output, High-include-Renal Tubular Transport, Inborn Errors', 'Seizures-impact-Neoplasms', 'Seizures-enhance-Neoplasms', 'Cardiovascular Diseases-underlie-Heart Diseases', 'Drug-Related Side Effects and Adverse Reactions-result-Heart Diseases', 'Drug-Related Side Effects and Adverse Reactions-associated-Heart Diseases', 'Heart Diseases-associated-Drug-Related Side Effects and Adverse Reactions', 'HIV Infections-report-Acquired Immunodeficiency Syndrome', 'Osteoporotic Fractures-affected-Osteoarthritis', 'Osteoarthritis-influence-Fractures, Bone', 'Dementia-differentiated-Parkinson Disease, Secondary', 'Parkinson Disease-differentiated-Parkinson Disease, Secondary', 'Upper Extremity Deep Vein Thrombosis-place-Arteriovenous Fistula', 'Sleep Apnea, Obstructive-exposed-Hypoxia', 'Arrhythmias, Cardiac-increase-Heart Diseases', 'Atrial Fibrillation-surpass-Arrhythmias, Cardiac', 'Inflammation-occur-HIV Infections', 'Hematemesis-present-Liver Cirrhosis', 'Liver Cirrhosis-diagnosed-Werner Syndrome', 'Werner Syndrome-considered-Liver Cirrhosis', 'Arthritis, Infectious-increase-Death', 'Death-account-Dementia', 'Death-investigate-Memory Disorders', 'Nijmegen Breakage Syndrome-associated-Neoplasms', 'Neoplasms-associated-Nijmegen Breakage Syndrome', 'Nijmegen Breakage Syndrome-associated-Immunologic Deficiency Syndromes', 'Immunologic Deficiency Syndromes-associated-Nijmegen Breakage Syndrome', 'Nijmegen Breakage Syndrome-associated-Microcephaly', 'Microcephaly-associated-Nijmegen Breakage Syndrome', 'Acute Kidney Injury-develop-Renal Insufficiency, Chronic', 'Acute Kidney Injury-fail-Death', 'Delirium-include-Hypertension', 'Hemorrhage-reveal-Death', 'Heart Block-receive-Pain', 'Heart Block-given-Femoral Fractures', 'Pain Insensitivity, Congenital-given-Femoral Fractures', 'Femoral Fractures-given-Pain', 'Femoral Fractures-control-Pain', 'Heart Block-given-Wounds and Injuries', 'Pain Insensitivity, Congenital-given-Wounds and Injuries', 'Wounds and Injuries-given-Pain', 'Wounds and Injuries-control-Pain', 'Heart Block-control-Pain', 'Femoral Fractures-help-Pain', 'Sarcopenia-examine-Death', 'Skin Neoplasms-treat-Melanoma', 'Coronary Artery Disease-associated-Cerebrovascular Disorders', 'Cerebrovascular Disorders-associated-Coronary Artery Disease', 'Pulmonary Disease, Chronic Obstructive-associated-Hyperlipidemias', 'Hyperlipidemias-associated-Pulmonary Disease, Chronic Obstructive', 'Pulmonary Disease, Chronic Obstructive-associated-Hypertension', 'Hypertension-associated-Pulmonary Disease, Chronic Obstructive', 'Peptic Ulcer-associated-Hypertension', 'Hypertension-associated-Peptic Ulcer', 'Peptic Ulcer-associated-Cerebrovascular Disorders', 'Cerebrovascular Disorders-associated-Peptic Ulcer', 'Pulmonary Disease, Chronic Obstructive-improve-Pulmonary Heart Disease', 'Death-linked-Drug-Related Side Effects and Adverse Reactions', 'Fibrosis-reduce-Idiopathic Pulmonary Fibrosis', 'Vomiting-associated-Fever', 'Fever-associated-Vomiting', 'Vomiting-associated-Dehydration', 'Dehydration-associated-Vomiting', 'Hypogonadism-occur-Spinal Cord Injuries', 'Glaucoma-access-Dementia', 'Hypertension-associated-Drug-Related Side Effects and Adverse Reactions', 'Drug-Related Side Effects and Adverse Reactions-associated-Hypertension', 'Diabetes Mellitus-associated-Drug-Related Side Effects and Adverse Reactions', 'Drug-Related Side Effects and Adverse Reactions-associated-Diabetes Mellitus', 'Acute Kidney Injury-associated-Drug-Related Side Effects and Adverse Reactions', 'Drug-Related Side Effects and Adverse Reactions-associated-Acute Kidney Injury', 'Acute Kidney Injury-included-Renal Insufficiency, Chronic', 'Inflammation-compromised-HIV Infections', 'Renal Insufficiency, Chronic-range-Acute Kidney Injury', 'Renal Insufficiency, Chronic-include-Hypertension', 'Kidney Diseases-include-Renal Insufficiency, Chronic', 'Renal Insufficiency, Chronic-include-Obesity', 'Renal Insufficiency, Chronic-include-Obesity, Abdominal', 'Diabetes Mellitus-include-Fibrosis', 'Hypertension-include-Fibrosis', 'Periodontitis-apprais-Inflammation', 'Periodontitis-underlie-Inflammation', 'Periodontal Diseases-recognized-Periodontitis', 'Drug-Related Side Effects and Adverse Reactions-face-Carcinoma, Non-Small-Cell Lung', 'Atrophy-include-Drug-Related Side Effects and Adverse Reactions', 'Purpura-include-Drug-Related Side Effects and Adverse Reactions', 'Telangiectasis-include-Drug-Related Side Effects and Adverse Reactions', 'Coinfection-include-Drug-Related Side Effects and Adverse Reactions', 'Dementia-affected-Stroke', 'Death-investigate-Osteoarthritis', 'Death-investigate-Osteoporosis', 'Osteoarthritis-reduce-Death', 'Myotonic Dystrophy-reduce-Death', 'Stroke-interfere-Ischemia', 'Stroke-impaired-Ischemia', 'Psychomotor Disorders-affected-Dementia', 'Atherosclerosis-treat-Infections', 'Cerebral Small Vessel Diseases-associated-Memory Disorders', 'Memory Disorders-associated-Cerebral Small Vessel Diseases', 'Cerebral Small Vessel Diseases-work-Memory Disorders', 'Dementia-manage-Diabetes Mellitus', 'Nervous System Diseases-show-Alzheimer Disease', 'Renal Insufficiency, Chronic-demonstrate-Myocardial Stunning', 'Diabetes Mellitus-seen-Hypertension', 'Diabetes Mellitus-seen-Coronary Artery Disease', 'Diabetes Mellitus-seen-Pulmonary Disease, Chronic Obstructive', 'Renal Insufficiency, Chronic-predispose-Anemia', 'Renal Insufficiency, Chronic-predispose-Chronic Kidney Disease-Mineral and Bone Disorder', 'Dementia-associate-Parkinson Disease', 'Parkinson Disease-associate-Dementia', 'Muscular Atrophy-characterized-Thinness', 'Sarcopenia-characterized-Thinness', 'Muscle Weakness-characterized-Thinness', 'Chronic Disease-diagnose-Otitis', 'Cardiovascular Diseases-investigate-Stroke', 'Werner Syndrome-lose-Sarcopenia', 'Cardiovascular Diseases-increase-Arthritis, Rheumatoid', 'Arthritis, Rheumatoid-take-Arthritis', 'Bone Neoplasms-correct-Abnormalities, Drug-Induced', 'Osteoporosis-identify-Fractures, Bone', 'Cartilage Diseases-observe-Osteoarthritis', 'Dementia-precede-Heart Failure', 'Sarcopenia-including-Fractures, Bone', 'Sarcopenia-involve-Fractures, Bone', 'Pulmonary Fibrosis-associated-Idiopathic Pulmonary Fibrosis', 'Idiopathic Pulmonary Fibrosis-associated-Pulmonary Fibrosis', 'Chest Pain-exclude-Coronary Artery Disease', 'Emphysema-associated-Idiopathic Pulmonary Fibrosis', 'Idiopathic Pulmonary Fibrosis-associated-Emphysema', 'Pulmonary Arterial Hypertension-associated-Idiopathic Pulmonary Fibrosis', 'Idiopathic Pulmonary Fibrosis-associated-Pulmonary Arterial Hypertension', 'Lung Neoplasms-associated-Idiopathic Pulmonary Fibrosis', 'Idiopathic Pulmonary Fibrosis-associated-Lung Neoplasms', 'Cardiovascular Diseases-associated-Idiopathic Pulmonary Fibrosis', 'Idiopathic Pulmonary Fibrosis-associated-Cardiovascular Diseases', 'Inflammation-include-Hypoxia', 'Diabetes Mellitus-develop-Neoplasms', 'Graft vs Host Disease-experience-Diabetes Mellitus', 'HIV Infections-found-Tuberculosis, Meningeal', 'Death-reduce-Hip Fractures', 'Autoimmune Diseases-suffer-Infections', 'Myotonic Dystrophy-move-Renal Insufficiency, Chronic', 'Glucose Metabolism Disorders-isolated-Diabetes Mellitus', 'Arrhythmias, Cardiac-detected-Muscular Diseases', 'Arrhythmias, Cardiac-involve-Atrial Fibrillation', 'Arrhythmias, Cardiac-involve-Atrial Flutter', 'Arrhythmias, Cardiac-involve-Tachycardia, Supraventricular', 'Arrhythmias, Cardiac-involve-Sick Sinus Syndrome', 'HIV Infections-targeted-AIDS Arteritis, Central Nervous System', 'Hemorrhage-cause-Cardiovascular Diseases', 'Dyspnea-increase-Obesity', 'Dyspnea-reflect-Cardiovascular Diseases', 'Diabetes Mellitus-reflect-Cardiovascular Diseases', 'Muscular Diseases-characterized-Muscle Weakness', 'Hypertension-influenced-HIV Infections', 'Pulmonary Embolism-confirmed-Pulmonary Disease, Chronic Obstructive', 'Aortitis-suspected-Giant Cell Arteritis', 'Aortitis-complicated-Aneurysm', 'Giant Cell Arteritis-complicated-Aneurysm', 'Death-complicated-Aneurysm', 'Chronic Disease-found-Hypertension', 'Amenorrhea-defined-Kidney Diseases', 'Kidney Diseases-limited-Cardiovascular Diseases', 'Osteoarthritis-addressed-Cardiovascular Diseases', 'Alzheimer Disease-provide-Tauopathies', 'Diabetes Mellitus-lead-Peripheral Nervous System Diseases', 'Diabetes Mellitus-avoid-Hypoglycemia', 'Peripheral Arterial Disease-associated-Hearing Loss', 'Hearing Loss-associated-Peripheral Arterial Disease', 'Cardiovascular Diseases-prevent-Hearing Loss', 'Cushing Syndrome-associated-Muscular Atrophy', 'Muscular Atrophy-associated-Cushing Syndrome', 'Cushing Syndrome-compare-Obesity', 'Fatty Liver-differentiate-Fibrosis', 'Fatty Liver-predispose-Carcinoma, Hepatocellular', 'Fibrosis-predispose-Carcinoma, Hepatocellular', 'Epstein-Barr Virus Infections-base-Viremia', 'Epstein-Barr Virus Infections-base-Infections', 'Dementia-associate-Delirium', 'Delirium-associate-Dementia', 'Stroke-caused-Arterial Occlusive Diseases', 'Ischemia-lead-Nerve Degeneration', 'Neoplasm Invasiveness-identified-Colorectal Neoplasms', 'Inflammation-co-occur-Obesity', 'Inflammation-co-occur-HIV Infections', 'Fibrosis-include-Death, Sudden', 'Fibrosis-provide-Death, Sudden, Cardiac', 'Arrhythmias, Cardiac-include-Death, Sudden', 'Cardiomyopathy, Dilated-affect-Arrhythmias, Cardiac', 'Diabetes Mellitus-analysed-Renal Insufficiency, Chronic', 'Hypertension-analysed-Renal Insufficiency, Chronic', 'Hypertension-reach-Diabetes Mellitus', 'Neoplasms-display-Alzheimer Disease', 'Alzheimer Disease-display-Death', 'Brain Infarction-occur-Gastrointestinal Hemorrhage', 'Gastrointestinal Hemorrhage-associated-Cerebral Infarction', 'Cerebral Infarction-associated-Gastrointestinal Hemorrhage', 'Gastrointestinal Hemorrhage-improve-Cerebral Infarction', 'Neoplasms-associated-Carcinogenesis', 'Carcinogenesis-associated-Neoplasms', 'Parkinson Disease-associated-Osteoporosis', 'Osteoporosis-associated-Parkinson Disease', 'Spinal Dysraphism-arise-Parkinsonian Disorders', 'Parkinson Disease-arise-Parkinsonian Disorders', 'Ocular Hypertension-supplant-Cataract', 'Musculoskeletal Diseases-associated-Pain', 'Pain-associated-Musculoskeletal Diseases', 'Sepsis-reported-Death', 'Shock-reported-Death', 'Neoplasms-reported-Death', 'Sepsis-found-Communicable Diseases', 'Sepsis-found-Musculoskeletal Diseases', 'Autoimmune Diseases-lead-Inflammation', 'Fanconi Anemia-study-Neoplasms', 'Glioma-include-Neoplasms', 'Status Epilepticus-include-Neoplasms', 'Heart Diseases-include-Neoplasms', 'Muscle Hypotonia-include-Neoplasms', 'Usher Syndromes-include-Neoplasms', 'Hirschsprung Disease-include-Neoplasms', 'Critical Illness-progress-Inflammation', 'Critical Illness-include-Shock, Septic', 'Critical Illness-include-Malnutrition', 'Fistula-reduce-Infections', 'Hypertension-receive-Death', 'Atherosclerosis-lead-Heart Failure', 'Heart Failure-lead-Death', 'Death-sustain-Hip Fractures', 'Death-identified-Femoral Neck Fractures', 'Death-sustain-Femoral Neck Fractures', 'Xeroderma Pigmentosum-suffer-Neurodegenerative Diseases', 'Atherosclerosis-prove-Aortic Valve Stenosis', 'Fibrosis-provide-Aortic Valve Stenosis', 'Leukemia, Myeloid, Acute-achieve-Drug Resistant Epilepsy', 'Hypogonadism-indicated-Diabetes Mellitus, Type 2', 'Heart Valve Diseases-followed-Aortic Valve Stenosis', 'Aortic Valve Insufficiency-followed-Heart Valve Diseases', 'Mitral Valve Stenosis-caused-Rheumatic Fever', 'Neurodegenerative Diseases-caused-Mastocytosis, Systemic', 'Heart Valve Diseases-caused-Congenital, Hereditary, and Neonatal Diseases and Abnormalities', 'Heart Valve Diseases-caused-Mastocytosis, Systemic', 'Heart Valve Diseases-caused-Endocarditis', 'Infections-present-Bronchitis', 'Infections-present-Vomiting', 'Infections-present-Apnea', 'Bronchitis-present-Cough', 'Bronchitis-present-Vomiting', 'Bronchitis-present-Apnea', 'Infections-lead-Fatigue', 'Communicable Diseases-follow-Wounds and Injuries', 'Infections-include-Gastroenteritis', 'Rupture-associated-Thrombosis', 'Thrombosis-associated-Rupture', 'Rupture-associated-Embolism', 'Embolism-associated-Rupture', 'Death-admitted-Acute Coronary Syndrome', 'Asthma-present-Death', 'Carcinoma, Hepatocellular-include-Death', 'Liver Failure-include-Death', 'Gastrointestinal Hemorrhage-include-Death', 'Parkinson Disease-demonstrate-Learning Disabilities', 'Fractures, Bone-evaluated-Osteoporosis', 'Death-appear-Parkinson Disease', 'Retinal Artery Occlusion-associate-Stroke', 'Stroke-associate-Retinal Artery Occlusion', 'Retinal Artery Occlusion-associate-Diabetes Mellitus', 'Diabetes Mellitus-associate-Retinal Artery Occlusion', 'Retinal Artery Occlusion-associate-Carotid Stenosis', 'Carotid Stenosis-associate-Retinal Artery Occlusion', 'Retinal Artery Occlusion-associate-Hyperlipidemias', 'Hyperlipidemias-associate-Retinal Artery Occlusion', 'Fibrosis-limit-Neoplasms', 'Neoplasms-maintain-Pain Insensitivity, Congenital', 'Diabetes Mellitus-serve-Retinal Artery Occlusion', 'Prostatitis-evaluated-Prostatic Neoplasms', 'Prostatitis-associate-Urinary Tract Infections', 'Urinary Tract Infections-associate-Prostatitis', 'Prostatitis-manage-Urinary Tract Infections', 'Dermatitis, Phototoxic-attenuate-Drug-Related Side Effects and Adverse Reactions', 'Hypothyroidism-cause-Anemia, Macrocytic', 'Hypothyroidism-cause-Kidney Diseases', 'Hyperthyroidism-associated-Death', 'Death-associated-Hyperthyroidism', 'Cataract-followed-Glycogen Storage Disease Type II', 'Glycogen Storage Disease Type II-followed-Anophthalmos', 'Infections-associated-Critical Illness', 'Critical Illness-associated-Infections', 'Neoplasms-cause-Drug-Related Side Effects and Adverse Reactions', 'Sepsis-support-Respiratory Tract Infections', 'Neoplasms-predict-Carcinoma, Squamous Cell', 'Neoplasms-exclude-Carcinoma, Squamous Cell', 'Appendicitis-cause-Abdominal Pain', 'Hyperkalemia-prescribe-Heart Failure', 'Diabetes Mellitus, Type 2-shown-Alzheimer Disease', 'Diabetes Mellitus, Type 2-exhibit-Alzheimer Disease', 'Diabetes Mellitus, Type 2-exhibit-Inflammation', 'Lupus Erythematosus, Systemic-associated-Thyroiditis, Autoimmune', 'Thyroiditis, Autoimmune-associated-Lupus Erythematosus, Systemic', 'Lupus Erythematosus, Systemic-associated-Thyroid Neoplasms', 'Thyroid Neoplasms-associated-Lupus Erythematosus, Systemic', 'Lupus Erythematosus, Systemic-associated-Graves Disease', 'Graves Disease-associated-Lupus Erythematosus, Systemic', 'Lupus Erythematosus, Systemic-demonstrate-Hashimoto Disease', 'Thyroiditis, Autoimmune-demonstrate-Hashimoto Disease', 'Thyroid Neoplasms-demonstrate-Hashimoto Disease', 'Graves Disease-demonstrate-Hashimoto Disease', 'Graves Disease-observed-Lupus Erythematosus, Systemic', 'Hashimoto Disease-observed-Lupus Erythematosus, Systemic', 'Thyroid Neoplasms-observed-Lupus Erythematosus, Systemic', 'Head and Neck Neoplasms-given-Pneumonia', 'Femoral Neck Fractures-require-Infections', 'Inflammation-mitigate-Brain Injuries', 'Shock, Septic-increase-Death', 'Death-decline-Heart Failure', 'Heart Failure-surpass-Death', 'Obesity, Abdominal-associated-Glucose Metabolism Disorders', 'Glucose Metabolism Disorders-associated-Obesity, Abdominal', 'Lung Diseases-limit-Infections', 'Joint Diseases-include-Inflammation', 'Dysbiosis-manifest-Heredodegenerative Disorders, Nervous System', 'Hearing Loss-elevate-Hypertension', 'Hyperhomocysteinemia-become-Hypertension', 'Gait Disorders, Neurologic-worsen-Paresis', 'Cardiomyopathies-lead-Ventricular Remodeling', 'Ventricular Remodeling-constitute-Fibrosis', 'Cardiomyopathies-lead-Heart Diseases', 'Fibrosis-constitute-Arrhythmias, Cardiac', 'Inflammation-lead-Ventricular Remodeling', 'Inflammation-lead-Heart Diseases', 'Neoplasms-compare-Cardiovascular Diseases', 'Neoplasms-reflect-Death', 'Breast Neoplasms-assessed-Neoplasms', 'Hypertension-reduce-Obesity', 'Obesity-curb-Cardiovascular Diseases', 'Inflammation-remain-Infections', 'Death-classified-Acquired Immunodeficiency Syndrome', 'Coinfection-report-HIV Infections', 'Tuberculosis-report-HIV Infections', 'Infections-co-infected-Tuberculosis', 'Infections-acquire-HIV Infections', 'Infections-report-HIV Infections', 'Diabetes Mellitus-followed-Seizures', 'Diabetes Mellitus-increase-Seizures', 'Diabetes Mellitus-support-Aneurysm', 'Diabetes Mellitus-identify-Seizures', 'Seizures-support-Aneurysm', 'Pituitary Neoplasms-include-Neoplasm Metastasis', 'Neuroma, Acoustic-include-Neoplasm Metastasis', 'Pituitary Neoplasms-include-Neoplasms', 'Neuroma, Acoustic-include-Neoplasms', 'Arbovirus Infections-stratified-HIV Infections', 'Respiratory Tract Diseases-stratified-HIV Infections', 'Neoplasms-compare-Colonic Neoplasms', 'Neoplasms-resemble-Colorectal Neoplasms', 'Neoplasms-resemble-Polyps', 'Neoplasms-resemble-Ulcer', 'Death-play-Cardiovascular Diseases', 'Death-play-Kidney Diseases', 'Death-play-Neoplasms', 'Psychoses, Substance-Induced-associated-Epilepsy', 'Epilepsy-associated-Psychoses, Substance-Induced', 'Diabetes Mellitus-prevent-Fetal Macrosomia', 'Diabetes, Gestational-prevent-Fetal Macrosomia', 'Obesity-prevent-Fetal Macrosomia', 'Musculoskeletal Diseases-accompanied-Eyelid Diseases', 'Musculoskeletal Diseases-accompanied-Blepharoptosis', 'Death-admitted-Heart Failure', 'Heredodegenerative Disorders, Nervous System-termed-AIDS Arteritis, Central Nervous System', 'Dementia-assess-Psychomotor Agitation', 'Death-prevent-Diabetes Mellitus', 'Death-reduce-HIV Infections', 'Cerebrovascular Disorders-viewed-Epilepsy', 'Stroke-viewed-Epilepsy', 'Infections-lead-Pyelonephritis', 'Infections-include-Pseudomonas Infections', 'Arthritis, Rheumatoid-distinguished-Inflammation', 'Autoimmune Diseases-distinguished-Inflammation', 'Mitochondrial Diseases-associated-Nervous System Diseases', 'Nervous System Diseases-associated-Mitochondrial Diseases', 'Diabetes Mellitus-cause-Mitochondrial Diseases', 'Mitochondrial Diseases-associated-Kidney Diseases', 'Kidney Diseases-associated-Mitochondrial Diseases', 'Neuromuscular Diseases-predispose-Gastrointestinal Diseases', 'Neuromuscular Diseases-predispose-Communicable Diseases', 'Gastrointestinal Diseases-predispose-Fractures, Bone', 'Communicable Diseases-predispose-Osteoporosis', 'Communicable Diseases-predispose-Fractures, Bone', 'Inflammation-result-Arthritis', 'Neoplasms-include-Breast Neoplasms', 'Arrhythmias, Cardiac-improve-Death', 'Cardiovascular Diseases-investigate-Atherosclerosis', 'Epilepsy-known-Seizures', 'Inflammation-lead-Fatigue', 'Shock, Hemorrhagic-identify-Death', 'Death-include-Multiple Organ Failure', 'Death-include-Heart Arrest', 'Alzheimer Disease-characterized-Neurodegenerative Diseases', 'Atrophy-include-Neurodegenerative Diseases', 'Stroke-become-Atrial Fibrillation', 'Pain-improve-Diabetic Neuropathies', 'Wounds and Injuries-considered-Alcoholism', 'Diabetes Mellitus, Type 2-link-Dementia', 'Pneumonia-include-Respiratory Tract Infections', 'Bronchiolitis-include-Respiratory Tract Infections', 'Alzheimer Disease-produce-Nervous System Diseases', 'Respiratory Tract Diseases-complicated-Infections', 'Myelodysplastic Syndromes-associated-Heart Failure', 'Heart Failure-associated-Myelodysplastic Syndromes', 'Myelodysplastic Syndromes-associated-Hematologic Diseases', 'Hematologic Diseases-associated-Myelodysplastic Syndromes', 'Myelodysplastic Syndromes-associated-Fatigue', 'Fatigue-associated-Myelodysplastic Syndromes', 'Myelodysplastic Syndromes-associated-Infections', 'Infections-associated-Myelodysplastic Syndromes', 'Myelodysplastic Syndromes-associated-Contusions', 'Contusions-associated-Myelodysplastic Syndromes', 'Myelodysplastic Syndromes-associated-Hemorrhage', 'Hemorrhage-associated-Myelodysplastic Syndromes', 'Myelodysplastic Syndromes-associated-Cell Transformation, Viral', 'Cell Transformation, Viral-associated-Myelodysplastic Syndromes', 'Neoplasms-associated-Heart Failure', 'Heart Failure-associated-Neoplasms', 'Neoplasms-associated-Hematologic Diseases', 'Hematologic Diseases-associated-Neoplasms', 'Neoplasms-associated-Contusions', 'Contusions-associated-Neoplasms', 'Neoplasms-associated-Cell Transformation, Viral', 'Cell Transformation, Viral-associated-Neoplasms', 'Hematologic Diseases-related-Heart Failure', 'Fatigue-related-Heart Failure', 'Infections-related-Heart Failure', 'Contusions-related-Heart Failure', 'Hemorrhage-related-Heart Failure', 'Wounds and Injuries-classify-Fractures, Bone', 'Diabetes Mellitus-related-Chronic Disease', 'Adrenal Insufficiency-report-Alcoholism', 'Adrenal Insufficiency-report-Diabetes Mellitus', 'Alcoholism-report-Diabetes Mellitus', 'Epilepsy-mentioned-Death', 'Death-increase-Chronic Disease', 'Penile Induration-associated-Infections', 'Infections-associated-Penile Induration', 'Death-influenced-Pain', 'Arthritis, Psoriatic-associated-Psoriasis', 'Psoriasis-associated-Arthritis, Psoriatic', 'Joint Diseases-associated-Psoriasis', 'Psoriasis-associated-Joint Diseases', 'Basal Ganglia Diseases-associated-Parkinson Disease', 'Parkinson Disease-associated-Basal Ganglia Diseases', 'Low Back Pain-diagnosed-Osteoarthritis', 'Death-present-Hip Fractures', 'Neoplasms-impact-Death', 'Cardiovascular Diseases-vary-Heart Valve Diseases', 'Cardiovascular Diseases-vary-Heart Failure', 'Heart Failure-vary-Heart Valve Diseases', 'Heart Valve Diseases-vary-Neoplasms', 'Heart Failure-vary-Neoplasms', 'Neoplasms-decrease-Infections', 'Myotonic Dystrophy-influenced-Glucose Metabolism Disorders', 'Diabetes Mellitus-receive-Obesity', 'Obesity-interact-Metabolic Syndrome', 'Spinocerebellar Ataxias-include-Neurodegenerative Diseases', 'HIV Infections-associated-Osteoporosis', 'Osteoporosis-associated-HIV Infections', 'Shoulder Dislocation-provide-Pain', 'Respiratory Tract Infections-lead-Death', 'Alzheimer Disease-work-Amyloidosis', 'Alzheimer Disease-drive-Atrophy', 'Nerve Degeneration-work-Amyloidosis', 'Nerve Degeneration-drive-Atrophy', 'Hypertension-increase-Fractures, Bone', 'Amyloidosis-drive-Atrophy', 'Fractures, Bone-found-Osteoporosis', 'Leukemia, Myelomonocytic, Chronic-stratified-Myelodysplastic Syndromes', 'Myelodysplastic Syndromes-cope-Anemia', 'Leukemia, Myelomonocytic, Chronic-cope-Anemia', 'Blister-heralded-Eczema', 'Blister-associated-Neurodegenerative Diseases', 'Neurodegenerative Diseases-associated-Blister', 'Eczema-associated-Neurodegenerative Diseases', 'Neurodegenerative Diseases-associated-Eczema', 'Death-decline-Leukemia, Myeloid, Acute', 'Obesity-compare-Death', 'Obesity-seen-Death', 'Coronary Artery Disease-arise-Death', 'Pain-identify-Osteochondroma', 'Skin Diseases-reported-Skin Neoplasms', 'Fever-develop-Communicable Diseases', 'Fever-develop-Gastroenteritis', 'Hypertension-considered-Colitis, Ischemic', 'Cardiovascular Diseases-considered-Colitis, Ischemic', 'Fever-occur-Pneumonia', 'Fever-occur-Dementia', 'Fever-occur-Constipation', 'Fever-occur-Sleep Wake Disorders', 'Pain-experience-Tooth, Impacted', 'Xerostomia-experience-Tooth, Impacted', 'Alzheimer Disease-show-Brain Diseases', 'Obesity-target-Cardiovascular Diseases', 'Neoplasms-remain-Sepsis', 'Inflammation-prevent-Alzheimer Disease', 'Obesity-associated-Musculoskeletal Diseases', 'Musculoskeletal Diseases-associated-Obesity', 'Obesity-associated-Myocardial Infarction', 'Myocardial Infarction-associated-Obesity', 'Spinal Injuries-include-Deglutition Disorders', 'Deglutition Disorders-prevent-Pneumonia, Aspiration', 'Chronic Disease-associated-Neoplasms', 'Neoplasms-associated-Chronic Disease', 'Parkinsonian Disorders-need-Parkinson Disease', 'Parkinson Disease-related-Cerebrovascular Disorders', 'Aortic Aneurysm, Abdominal-caused-Hemorrhage', 'Rupture-caused-Hemorrhage', 'Death-caused-Hemorrhage', 'Aortic Aneurysm, Abdominal-carry-Death', 'Venous Thromboembolism-include-Postthrombotic Syndrome', 'Postthrombotic Syndrome-include-Death', 'Hypertension-prevent-Cardiovascular Diseases', 'Metabolic Diseases-overrepresented-Alzheimer Disease', 'Paranasal Sinus Neoplasms-selected-Neoplasms', 'Rhinitis, Allergic-associated-Neoplasms', 'Neoplasms-associated-Rhinitis, Allergic', 'Endophthalmitis-referred-Cataract', 'Parkinson Disease-speaking-Amnesia', 'Parkinson Disease-identify-Hearing Disorders', 'Meningeal Neoplasms-evolve-Neoplasms', 'Meningeal Neoplasms-divide-Neoplasms', 'Ventricular Remodeling-accompany-Hypotension', 'Alzheimer Disease-score-Sleep Wake Disorders', 'Epilepsy, Absence-reported-Alzheimer Disease', 'Sleep Wake Disorders-reported-Alzheimer Disease', 'Vascular System Injuries-inhibit-Inflammation', 'Vascular System Injuries-inhibit-Hypertension', 'Cardiovascular Diseases-followed-Death', 'Acute Disease-lead-Aneurysm', 'Viremia-occur-Arbovirus Infections', 'Chronic Kidney Disease-Mineral and Bone Disorder-included-Metabolic Diseases', 'Chronic Kidney Disease-Mineral and Bone Disorder-included-Bone Diseases', 'Chronic Kidney Disease-Mineral and Bone Disorder-included-Death', 'Chronic Kidney Disease-Mineral and Bone Disorder-highlight-Death', 'Renal Insufficiency, Chronic-included-Metabolic Diseases', 'Renal Insufficiency, Chronic-included-Bone Diseases', 'Renal Insufficiency, Chronic-included-Death', 'Metabolic Diseases-contribute-Urinary Bladder, Neurogenic', 'Obesity-defined-Death', 'Sarcopenia-present-Death', 'Dementia-base-Postmortem Changes', 'Dementia-predict-Postmortem Changes', 'Sarcopenia-investigate-Weight Loss', 'Pain-seem-Cardiac Output, Low', 'Pain-incur-Cardiac Output, Low', 'Death-evaluated-Cataract', 'Hemophilia A-affect-Hemorrhage', 'Hemophilia A-affect-Infections', 'Hemophilia A-affect-Hepatitis, Viral, Human', 'Hemorrhage-affect-Infections', 'Hypertension-result-Craniocerebral Trauma', 'Hypertension-result-Respiratory Tract Infections', 'Hypertension-result-Neurodegenerative Diseases', 'Seizures-occur-Alzheimer Disease', 'Epilepsy-play-Alzheimer Disease', 'Inflammation-seem-Cerebral Infarction', 'Nervous System Diseases-result-Memory Disorders', 'Infertility, Female-associated-Death', 'Death-associated-Infertility, Female', 'Infertility, Female-evaluated-Inflammation', 'Inflammation-evaluated-Necrosis', 'Hemorrhage-complicated-Shock, Hemorrhagic', 'Diverticulitis-occur-Infections', 'Diverticulitis-occur-Colonic Neoplasms', 'Diverticulosis, Colonic-complicate-Gastrointestinal Hemorrhage', 'Diverticular Diseases-reveal-Colonic Neoplasms', 'Diverticulosis, Colonic-complicate-Diverticulitis', 'Diverticulosis, Colonic-diagnose-Diverticulitis', 'Diverticulitis-reveal-Colonic Neoplasms', 'Hemorrhage-reveal-Colonic Neoplasms', 'Diverticulum-complicated-Gastrointestinal Hemorrhage', 'Diverticulum-complicated-Diverticulitis', 'Acute Disease-lead-Death', 'Infections-mediated-Death', 'Sepsis-represent-Death', 'Sepsis-dysregulate-Infections', 'Cardiovascular Diseases-adjudicated-Death', 'Chronic Disease-involved-Obesity', 'Chronic Disease-involved-Diabetes Mellitus', 'Chronic Disease-involved-Coronary Artery Disease', 'Stroke-conceptualized-Hypotension', 'Obesity-involved-Osteoporosis', 'Diabetes Mellitus-involved-Osteoporosis', 'Coronary Artery Disease-involved-Osteoporosis', 'Renal Insufficiency-cause-Pulmonary Edema', 'Renal Insufficiency-cause-Pleural Effusion', 'Headache Disorders, Secondary-interpreted-Alzheimer Disease', 'Abnormalities, Drug-Induced-associated-Mitochondrial Diseases', 'Mitochondrial Diseases-associated-Abnormalities, Drug-Induced', 'Renal Insufficiency, Chronic-function-Cerebrovascular Disorders', 'Renal Insufficiency, Chronic-related-Cerebral Small Vessel Diseases', 'Renal Insufficiency, Chronic-associated-Cerebral Small Vessel Diseases', 'Cerebral Small Vessel Diseases-associated-Renal Insufficiency, Chronic', 'Cerebrovascular Disorders-live-Renal Insufficiency, Chronic', 'Renal Insufficiency, Chronic-function-Vascular Calcification', 'Renal Insufficiency, Chronic-function-Inflammation', 'Renal Insufficiency, Chronic-live-Death', 'Cerebrovascular Disorders-function-Inflammation', 'Vascular Calcification-function-Inflammation', 'Memory Disorders-manage-Alzheimer Disease', 'Dementia-identify-Psychomotor Agitation', 'Dementia-identify-Sleep Wake Disorders', 'Asthma-followed-Infections', 'Ocular Hypertension-implicated-Mitochondrial Diseases', 'Glaucoma-exposed-Ocular Hypertension', 'Colitis, Ulcerative-undergo-Colorectal Neoplasms', 'Aneurysm, Ruptured-related-Hydrocephalus', 'Cataract-calculated-Death', 'Death-accounted-Wounds and Injuries', 'HIV Infections-use-Death', 'Death-develop-Shock, Septic', 'Death-suffer-Kidney Failure, Chronic', 'Shock, Septic-suffer-Kidney Failure, Chronic', 'Death-report-Heart Diseases', 'Neoplasms-comprise-Adenoma', 'Neoplasms-comprise-Neoplasm Metastasis', 'Neurodegenerative Diseases-range-Neoplasms', 'Obesity-expect-Diabetes Mellitus', 'Spinal Cord Injuries-characterised-Paraplegia', 'Spinal Cord Injuries-characterised-Quadriplegia', 'Paraplegia-com-pare-Quadriplegia', 'Pneumonia-based-Chest Pain', 'Infections-associated-Cardiac Output, Low', 'Cardiac Output, Low-associated-Infections', 'Death-decrease-Adenoma, Chromophobe', 'Breast Neoplasms-measure-Death', 'Liver Cirrhosis-associated-Fibrosis', 'Fibrosis-associated-Liver Cirrhosis', 'Liver Cirrhosis-defined-Fibrosis', 'Alzheimer Disease-develop-Neurodegenerative Diseases', 'Dementia-targeted-Alzheimer Disease', 'Diabetes Mellitus-contribute-Sarcopenia', 'Endocrine System Diseases-contribute-Sarcopenia', 'Delirium-enable-Headache Disorders, Secondary', 'Pyuria-related-Fever', 'Cardiac Output, Low-occurred-Wounds and Injuries', 'Cardiac Output, Low-occurred-Death', 'Neurodegenerative Diseases-related-Exocrine Pancreatic Insufficiency', 'Multiple Sclerosis-related-Exocrine Pancreatic Insufficiency', 'Immunologic Deficiency Syndromes-related-Exocrine Pancreatic Insufficiency', 'Alzheimer Disease-related-Malnutrition', 'Alzheimer Disease-related-Exocrine Pancreatic Insufficiency', 'Thrombosis-prevent-Acute Disease', 'Brain Injuries, Traumatic-lessen-Edema', 'Cachexia-defined-Metabolic Syndrome', 'Nerve Degeneration-lessen-Edema', 'Alzheimer Disease-lessen-Edema', 'Amyotrophic Lateral Sclerosis-lessen-Edema', 'Cachexia-overcome-Heart Failure', 'Neoplasms-include-Cachexia', 'Heart Failure-include-Cachexia', 'Neoplasms-include-Sarcopenia', 'Heart Failure-include-Sarcopenia', 'Death-ascribed-Neoplasms', 'Pain-indicate-Fatigue', 'Vascular Remodeling-promote-Inflammation', 'Hypertension-characterized-Vascular Remodeling', 'Cataract-cause-Vision Disorders', 'Kidney Diseases-mapping-Hypotension', 'Sarcopenia-prevent-Muscular Diseases', 'Obesity, Abdominal-play-Metabolic Syndrome', 'Multiple Myeloma-remain-Neoplasms', 'Thrombosis-trigger-Bradycardia', 'Neoplasms-derived-Hematologic Neoplasms', 'Hematologic Neoplasms-derived-Multiple Myeloma', 'Adenoma-classified-Neoplasms', 'Adenoma-account-Neoplasms', 'Cerebrovascular Disorders-advance-Neurotoxicity Syndromes', 'Urinary Incontinence-include-Dementia', 'Neurodegenerative Diseases-advance-Neurotoxicity Syndromes', 'Coinfection-result-Dysbiosis', 'Headache Disorders, Secondary-include-Cough', 'Headache Disorders, Secondary-evaluated-Cough', 'Headache Disorders, Secondary-include-Pneumonia, Aspiration', 'Headache Disorders, Secondary-recorded-Pneumonia, Aspiration', 'Cough-associated-Pneumonia', 'Pneumonia-associated-Cough', 'Cough-associated-Weight Loss', 'Weight Loss-associated-Cough', 'Pneumonia-associated-Weight Loss', 'Weight Loss-associated-Pneumonia', 'Inflammation-accelerate-Vascular Calcification', 'Gastrointestinal Hemorrhage-decrease-Peptic Ulcer', 'Gastrointestinal Hemorrhage-decrease-Infections', 'Gastrointestinal Hemorrhage-increase-Diverticular Diseases', 'Gastrointestinal Hemorrhage-increase-Angiodysplasia', 'Pain-under-reported-Alzheimer Disease', 'Diabetes Mellitus-identified-Hemolytic-Uremic Syndrome', 'Cold Injury-increase-Death', 'Cold Injury-increase-Cardiovascular Diseases', 'Cold Injury-increase-Stroke', 'Cold Injury-increase-Lung Diseases', 'Memory Disorders-follow-Brain Damage, Chronic', 'Obesity-cloude-Metabolic Syndrome', 'Neurogenic Inflammation-play-Chronic Pain', 'Glaucoma-detected-Inert Gas Narcosis', 'Glaucoma-detected-Retinitis', 'Acute Kidney Injury-develop-Diabetes Mellitus', 'Acute Kidney Injury-develop-Pneumonia', 'Dementia-correlated-Drug-Related Side Effects and Adverse Reactions', 'Drug-Related Side Effects and Adverse Reactions-altered-Dementia', 'Neoplasms-achieve-Postpartum Hemorrhage', 'Dementia-adjusted-Chronic Disease', 'Atrial Fibrillation-adjusted-Chronic Disease', 'Atrial Fibrillation-show-Dementia', 'Atrial Fibrillation-show-Stroke', 'Atrial Fibrillation-show-Coronary Artery Disease', 'Atrial Fibrillation-increase-Coronary Artery Disease', 'Myoclonus-review-Brain Neoplasms', 'Communicable Diseases-followed-Heart Diseases', 'Dementia-focus-Delirium', 'Demyelinating Diseases-provide-Alzheimer Disease', 'Atrial Fibrillation-emerge-Heart Valve Diseases', 'Heart Valve Diseases-related-Syncope', 'Cardiovascular Diseases-accelerate-Coronary Artery Disease', 'Death-observed-Mastocytosis, Systemic', 'Sarcopenia-minimize-Renal Insufficiency, Chronic', 'Hyponatremia-measured-Death', 'Hyponatremia-fall-Wounds and Injuries', 'Obesity-counteract-Cerebrovascular Disorders', 'Oculocerebrorenal Syndrome-explore-Lupus Erythematosus, Systemic', 'Status Epilepticus-associated-Hypotension', 'Hypotension-associated-Status Epilepticus', 'Hypotension-associated-Infections', 'Infections-associated-Hypotension', 'Inflammation-associated-Nausea', 'Nausea-associated-Inflammation', 'Inflammation-associated-Vomiting', 'Vomiting-associated-Inflammation', 'Death-correlate-Sarcopenia', 'Wounds and Injuries-lead-Cartilage Diseases', 'Cartilage Diseases-lead-Pain', 'Glaucoma-associated-Parkinson Disease', 'Parkinson Disease-associated-Glaucoma', 'Nervous System Diseases-lead-Somatosensory Disorders', 'Stroke-lead-Somatosensory Disorders', 'Liver Failure-differentiated-Fibrosis', 'Flushing-associated-Neoplasms', 'Neoplasms-associated-Flushing', 'Rheumatic Fever-show-Heart Valve Diseases', 'Dementia-suffer-Pain', 'Heart Failure-decrease-Thromboembolism', 'Neoplasms-encountered-Necrosis', 'Mastocytosis, Systemic-associated-Periodontitis', 'Periodontitis-associated-Mastocytosis, Systemic', 'Pain-increase-Fatigue', 'Obesity-diagnosed-Diabetes Mellitus', 'Fibrosis-reduce-Hypertension', 'Cartilage Diseases-target-Osteoarthritis', 'Neck Pain-report-Fractures, Bone', 'Pain-report-Fractures, Bone', 'Coma-deny-Neurologic Manifestations', 'Neck Pain-considered-Neurologic Manifestations', 'Fractures, Bone-unassociated-Neck Pain', 'Vascular Calcification-result-Cardiomyopathy, Hypertrophic', 'Hepatitis C-treat-Infections', 'Tuberculosis-translated-Hepatitis C', 'Sexual Dysfunction, Physiological-affect-Renal Insufficiency, Chronic', 'Drug-Related Side Effects and Adverse Reactions-occur-Hematologic Diseases', 'Death-found-Prostatic Hyperplasia', 'Death-found-Dyslipidemias', 'Werner Syndrome-lead-Myocardial Infarction', 'Werner Syndrome-lead-Death', 'Hematoma, Subdural-associated-Wounds and Injuries', 'Wounds and Injuries-associated-Hematoma, Subdural', 'Death-observed-Parkinson Disease', 'Ulcer-perform-Postoperative Complications', 'Drug-Related Side Effects and Adverse Reactions-altered-Heredodegenerative Disorders, Nervous System', 'Stiff-Person Syndrome-associated-Death', 'Death-associated-Stiff-Person Syndrome', 'Death-performed-Dementia', 'Stroke-live-Diabetes Mellitus', 'Hypertension-associated-Heart Diseases', 'Heart Diseases-associated-Hypertension', 'Chronic Pain-associated-Hypertension', 'Hypertension-associated-Chronic Pain', 'Diabetes Mellitus-diagnosed-Chronic Disease', 'Chronic Pain-associated-Heart Diseases', 'Heart Diseases-associated-Chronic Pain', 'Occupational Diseases-predict-Psychoses, Substance-Induced', 'Deglutition Disorders-define-Sleep Initiation and Maintenance Disorders', 'Seizures-receive-Oculocerebrorenal Syndrome', 'Muscle Weakness-based-Sarcopenia', 'Dementia-subdivided-Parkinson Disease', 'Infertility, Female-segregated-Hypogonadism', 'Aneurysm-persist-Alzheimer Disease', 'Neoplasms-increased-HIV Infections', 'Death-increased-HIV Infections', 'Neoplasms-program-Acquired Immunodeficiency Syndrome', 'Polyradiculopathy-respond-Spinal Cord Injuries', 'Polyradiculopathy-respond-Muscular Disorders, Atrophic', 'Neoplasms-based-Meningeal Neoplasms', 'Cranial Nerve Injuries-follow-Hydrocephalus', 'Cranial Nerve Injuries-follow-Infections', 'Sarcopenia-diagnosed-Death', 'Hemorrhage-known-Vision Disorders', 'Hemorrhage-known-Glaucoma', 'Muscular Dystrophy, Duchenne-predispose-Sleep Wake Disorders', 'Atrial Fibrillation-protect-Fibrosis', 'Sleep Apnea, Obstructive-hypoventilate-Respiratory Insufficiency', 'Muscular Dystrophy, Duchenne-characterized-Sleep Wake Disorders', 'Muscular Dystrophy, Duchenne-characterized-Apnea', 'Muscular Dystrophy, Duchenne-characterized-Hypercapnia', 'Muscular Dystrophy, Duchenne-characterized-Hypoventilation', 'Muscular Dystrophy, Duchenne-develop-Respiratory Insufficiency', 'Sleep Wake Disorders-characterized-Apnea', 'Sleep Wake Disorders-characterized-Hypercapnia', 'Sleep Wake Disorders-characterized-Hypoventilation', 'Sleep Wake Disorders-characterized-Respiratory Insufficiency', 'Sleep Wake Disorders-develop-Respiratory Insufficiency', 'Apnea-develop-Respiratory Insufficiency', 'Hypercapnia-develop-Respiratory Insufficiency', 'Hypoventilation-develop-Respiratory Insufficiency', 'Central Nervous System Infections-achieved-Pneumococcal Infections', 'Central Nervous System Infections-eliminate-Tuberculosis', 'Pneumococcal Infections-eliminate-Tuberculosis', 'Infections-reflect-Death', 'Ventricular Premature Complexes-compared-Heart Failure', 'Dyslipidemias-include-Myotonic Dystrophy', 'Obesity-include-Myotonic Dystrophy', 'Signs and Symptoms, Respiratory-lead-Death', 'Death-return-Mobility Limitation', 'Alzheimer Disease-confined-Ossification of Posterior Longitudinal Ligament', 'Muscular Diseases-experience-Sarcopenia', 'Breast Neoplasms-attributed-Neoplasms', 'Breast Neoplasms-change-Neoplasms', 'Neoplasms-OBJECTIVE-Adenoma', 'Neurotoxicity Syndromes-increased-Alzheimer Disease', 'Periodontal Diseases-associated-Mastocytosis, Systemic', 'Mastocytosis, Systemic-associated-Periodontal Diseases', 'Myocardial Infarction-improve-Teratoma', 'Brain Injury, Chronic-evolve-Brain Injuries, Traumatic', 'Cerebrovascular Disorders-focus-Brain Injuries, Traumatic', 'Cerebrovascular Disorders-lead-Brain Injuries, Traumatic', 'Neoplasm Invasiveness-isolated-Pneumococcal Infections', 'Mitral Valve Insufficiency-lead-Heart Failure', 'Mitral Valve Stenosis-lead-Heart Failure', 'Neoplasms-lead-Breast Neoplasms', 'Adenomatous Polyposis Coli-lead-Breast Neoplasms', 'Stroke-derived-Death', 'Breast Neoplasms-based-Neoplasms', 'Dementia-live-Hip Fractures', 'Consciousness Disorders-associated-Stroke', 'Stroke-associated-Consciousness Disorders', 'Headache Disorders, Secondary-associated-Sleep Initiation and Maintenance Disorders', 'Sleep Initiation and Maintenance Disorders-associated-Headache Disorders, Secondary', 'Consciousness Disorders-associated-Sleep Initiation and Maintenance Disorders', 'Sleep Initiation and Maintenance Disorders-associated-Consciousness Disorders', 'Drug-Related Side Effects and Adverse Reactions-induce-Cocaine-Related Disorders', 'Delirium-recognise-Liver Failure, Acute', 'Dementia-contrasted-Delirium', 'Cardiovascular Diseases-combate-Death', 'Vascular Calcification-treated-Hypertension', 'Cardiovascular Diseases-treated-Hypertension', 'Prostatitis-enrolled-Diabetes Mellitus', 'Prostatitis-divide-Diabetes Mellitus', 'Prostatitis-undergo-Diabetes Mellitus', 'Cardiovascular Diseases-present-Atherosclerosis', 'Diabetes Mellitus-present-Cardiovascular Diseases', 'Dyslipidemias-present-Cardiovascular Diseases', 'Hypertension-present-Cardiovascular Diseases', 'Obesity-present-Cardiovascular Diseases', 'Xerostomia-found-Deglutition Disorders', 'Cumulative Trauma Disorders-diagnosed-Deglutition Disorders', 'Xerostomia-contribute-Deglutition Disorders', 'Arthralgia-observed-Infections', 'Fever-observed-Infections', 'Cardiomyopathy, Dilated-identify-Heart Diseases', 'Hyperthyroidism-induce-Hyperglycemia', 'Intervertebral Disc Degeneration-associated-Back Pain', 'Back Pain-associated-Intervertebral Disc Degeneration', 'Multiple Sclerosis-implicated-Parkinson Disease', 'Multiple Sclerosis-implicated-Narcolepsy', 'Dementia-observed-Delirium', 'Delirium-defined-Dementia', 'Death-associated-Hepatitis C', 'Hepatitis C-associated-Death', 'Infections-occur-Kidney Diseases', 'Inflammation-enhance-Cardiovascular Diseases', 'Inflammation-enhance-Gout', 'Obesity-attenuate-Hyperglycemia', 'Obesity-attenuate-Hyperinsulinism', 'Fatigue-followed-Anemia', 'Hemorrhage-develop-Coagulation Protein Disorders', 'Hematoma, Subdural, Chronic-operated-Craniocerebral Trauma', 'Atherosclerosis-tend-Constriction, Pathologic', 'Thrombosis-occur-Protein S Deficiency', 'Pulmonary Disease, Chronic Obstructive-predict-Infections', 'Urinary Bladder Diseases-related-Kidney Diseases', 'Urinary Bladder Diseases-related-Lupus Nephritis', 'Urinary Bladder Diseases-related-Glomerulonephritis, Membranous', 'Pneumonia-improve-Death', 'Seizures-contribute-Chronic Disease', 'Seizures-assessed-Low Back Pain', 'Nerve Degeneration-lead-Dementia', 'Hypertension-suggest-Blepharoptosis', 'Diabetes Mellitus-suggest-Blepharoptosis', 'Atrial Fibrillation-play-Hypertension', 'Hypertension-stimulate-Inflammation', 'Hypertension-drive-Atrial Fibrillation', 'Inflammation-drive-Atrial Fibrillation', 'Atrial Fibrillation-underlie-Hypertension', 'Stroke-underlie-Hypertension', 'Hemorrhage-underlie-Hypertension', 'Cardiovascular Diseases-known-Hypertension', 'Alzheimer Disease-treat-Psychoses, Substance-Induced', 'Death-related-Drug-Related Side Effects and Adverse Reactions', 'Hypertension-sustain-Delirium', 'Delirium-sustain-Neoplasms', 'Death-accompanied-Weight Loss', 'Metabolic Diseases-lead-Alzheimer Disease', 'Acute Kidney Injury-cause-Death', 'Fractures, Bone-suggest-Osteoporosis', 'Osteoporosis-involved-Osteoarthritis', 'Death-delivered-Wounds and Injuries', 'Death-achieve-Hemorrhage', 'Thrombosis-suffer-Hemorrhage', 'Osteoarthritis, Knee-lead-Pain', 'Thyroid Diseases-comprise-Hypothyroidism', 'Thyroid Diseases-comprise-Hyperthyroidism', 'Hypothyroidism-defined-Hyperthyroidism', 'Venous Thromboembolism-occur-Inflammatory Bowel Diseases', 'Venous Thromboembolism-occur-Enteritis', 'Inflammatory Bowel Diseases-occur-Enteritis', 'Vascular Calcification-occur-Hyperlipidemias', 'Sclerosis-lead-Cardiomyopathy, Hypertrophic', 'Anemia, Iron-Deficiency-indicate-Sleep Initiation and Maintenance Disorders', 'Heart Failure-associated-Dysbiosis', 'Dysbiosis-associated-Heart Failure', 'Anemia, Iron-Deficiency-indicate-Anemia', 'Sleep Initiation and Maintenance Disorders-compare-Anemia', 'Sleep Initiation and Maintenance Disorders-indicate-Anemia', 'Respiratory Distress Syndrome-compromised-Osteoarthritis', 'Osteoarthritis-related-Respiratory Distress Syndrome', 'Atrophy-predispose-Fractures, Bone', 'Muscular Diseases-linked-Malignant Hyperthermia', 'Color Vision Defects-discriminate-Alzheimer Disease', 'Pulmonary Disease, Chronic Obstructive-share-Cardiovascular Diseases', 'Pulmonary Disease, Chronic Obstructive-produce-Inflammation', 'Cardiovascular Diseases-produce-Inflammation', 'Death-recommended-Pulmonary Disease, Chronic Obstructive', 'Brain Injuries, Traumatic-prevent-Craniocerebral Trauma', 'Sarcoma, Kaposi-live-HIV Infections', 'Coma-associated-Intracranial Hemorrhage, Hypertensive', 'Intracranial Hemorrhage, Hypertensive-associated-Coma', 'Hematoma-associated-Intracranial Hemorrhage, Hypertensive', 'Intracranial Hemorrhage, Hypertensive-associated-Hematoma', 'Spinal Cord Injuries-assess-Spinal Injuries', 'Metabolic Syndrome-linked-Death', 'Metabolic Diseases-lead-Hypertriglyceridemia', 'Metabolic Diseases-produce-Death', 'Hypertriglyceridemia-lead-Death', 'Brain Injuries, Diffuse-lead-Neurodegenerative Diseases', 'Hyperglycemia-cause-Diabetes Mellitus', 'Diabetes Mellitus-reduce-Alzheimer Disease', 'Alzheimer Disease-evaluate-Cerebellar Diseases', 'Amyloidosis-discuss-Alzheimer Disease', 'Dementia-discuss-Alzheimer Disease', 'Ulcer-reduce-Pain', 'Progeria-constitute-Genetic Diseases, Inborn', 'Osteoporotic Fractures-comprise-Fractures, Bone', 'Osteoporotic Fractures-followed-Fractures, Bone', 'Inflammation-contribute-Ventricular Remodeling', 'Hypertension-contribute-Ventricular Remodeling', 'Heart Diseases-include-Obesity', 'Coronary Artery Disease-known-Cardiomegaly', 'Cardiovascular Diseases-rise-Diabetes Mellitus', 'Cardiomegaly-associated-Death', 'Death-associated-Cardiomegaly', 'Hallucinations-experience-Memory Disorders', 'Cerebral Infarction-contribute-Death', 'Ischemia-contribute-Death', 'Death-related-Leukemia, Lymphocytic, Chronic, B-Cell', 'Death-control-Neoplasms', 'Diabetes, Gestational-diagnosed-Hypertension', 'Constriction, Pathologic-used-Aneurysm', 'Constriction, Pathologic-prevent-Thrombosis', 'Sarcopenia-wasting-Neoplasms', 'Neurotoxicity Syndromes-play-Alzheimer Disease', 'Alzheimer Disease-remain-Neurogenic Inflammation', 'Drug-Related Side Effects and Adverse Reactions-recommended-Long QT Syndrome', 'Death-related-Sarcopenia', 'Tumor Lysis Syndrome-associated-Death', 'Death-associated-Tumor Lysis Syndrome', 'Symptom Flare Up-worsen-Liver Failure', 'Symptom Flare Up-exacerbate-Pulmonary Fibrosis', 'Symptom Flare Up-exacerbate-Anemia, Aplastic', 'Symptom Flare Up-exacerbate-Liver Cirrhosis', 'Pulmonary Fibrosis-include-Liver Failure', 'Anemia, Aplastic-include-Liver Failure', 'Liver Cirrhosis-include-Liver Failure', 'Death-follow-Aortic Aneurysm', 'Cataract-diagnosed-Carcinoma, Squamous Cell', 'Neoplasms-associated-Cataract', 'Cataract-associated-Neoplasms', 'Carcinoma, Squamous Cell-associated-Cataract', 'Cataract-associated-Carcinoma, Squamous Cell', 'Keratosis, Actinic-associated-Cataract', 'Cataract-associated-Keratosis, Actinic', 'Vascular Calcification-reserved-Parathyroid Diseases', 'Vascular Calcification-reserved-Hyperparathyroidism', 'Inflammation-reserved-Parathyroid Diseases', 'Inflammation-reserved-Hyperparathyroidism', 'Bone Diseases, Metabolic-reserved-Parathyroid Diseases', 'Bone Diseases, Metabolic-reserved-Hyperparathyroidism', 'Parathyroid Diseases-reserved-Hyperparathyroidism', 'Fractures, Bone-divided-Osteoporosis', 'Nephritis-occur-Autoimmune Diseases', 'Nephritis-occur-Infections', 'Nephritis-occur-Hematologic Diseases', 'Acute Kidney Injury-occur-Autoimmune Diseases', 'Acute Kidney Injury-occur-Hematologic Diseases', 'Death-do-Metabolic Syndrome', 'Obesity-modulate-Fractures, Bone', 'Diabetes Mellitus-modulate-Fractures, Bone', 'Fractures, Bone-occur-Obesity', 'Glucose Intolerance-cause-Diabetes Mellitus', 'Osteoporosis-reduce-Obesity', 'Agammaglobulinemia-reported-Infections', 'Drug-Related Side Effects and Adverse Reactions-induce-Infections', 'Memory Disorders-suffer-Hip Fractures', 'Thromboembolism-benefit-Atrial Fibrillation', 'Death-assess-Infections', 'Parkinson Disease-mediate-Nerve Degeneration', 'Death-estimate-Pelvic Neoplasms', 'Neurodegenerative Diseases-develop-Stroke', 'Parkinson Disease-develop-Stroke', 'Death-find-Fractures, Bone', 'Pneumonia, Aspiration-decrease-Death', 'Death-admitted-Pneumonia, Aspiration', 'Drug Hypersensitivity-compare-Speech Disorders', 'Stroke-follow-Herpes Zoster', 'Speech Disorders-encode-Dementia', 'Stroke-increased-Infections', 'Diabetes Mellitus-discriminate-Acute Coronary Syndrome', 'Diabetes Mellitus-discriminate-Takotsubo Cardiomyopathy', 'Acute Coronary Syndrome-discriminate-Takotsubo Cardiomyopathy', 'Arteriovenous Malformations-incorporate-Anemia', 'Pain-test-Neoplasms', 'Arteriovenous Malformations-result-Hypoxia', 'Arteriovenous Malformations-place-Anemia, Iron-Deficiency', 'Telangiectasia, Hereditary Hemorrhagic-result-Hypoxia', 'Anemia, Iron-Deficiency-result-Hypoxia', 'Tendinopathy-account-Pain', 'Pain-influence-Neoplasms', 'Neurodegenerative Diseases-correlated-Alzheimer Disease', 'Death-influenced-Neoplasm Invasiveness', 'Hypopituitarism-occur-Ischemia', 'Hypopituitarism-occur-Hemorrhage', 'Death-include-Myocardial Infarction', 'Heart Diseases-protect-Atherosclerosis', 'Metabolic Syndrome-exist-Inflammation', 'Death-noted-Skin Diseases', 'Alzheimer Disease-colonize-Dementia', 'Alzheimer Disease-exacerbate-Inflammation', 'Dementia-exacerbate-Inflammation', 'Parkinson Disease-suffer-Oculomotor Nerve Diseases', 'Oculocerebrorenal Syndrome-herald-Fractures, Bone', 'Oculocerebrorenal Syndrome-fractures-Fractures, Bone', 'Parkinson Disease-possess-Neurologic Manifestations', 'Atherosclerosis-associated-Rhabdomyolysis', 'Rhabdomyolysis-associated-Atherosclerosis', 'Joint Diseases-seem-Bone Neoplasms', 'Neoplasms-administered-Drug-Related Side Effects and Adverse Reactions', 'Fractures, Bone-compare-Death', 'Death-estimated-Fractures, Bone', 'Alzheimer Disease-coexist-Obesity', 'Alzheimer Disease-coexist-Diabetes Mellitus', 'Alzheimer Disease-coexist-Hypertension', 'Alzheimer Disease-coexist-Cardiovascular Diseases', 'Metabolic Syndrome-drive-Alzheimer Disease', 'Metabolic Syndrome-cause-Mitochondrial Diseases', 'Migraine Disorders-include-Communicable Diseases', 'Glaucoma-include-Communicable Diseases', 'Optic Nerve Diseases-include-Communicable Diseases', 'Chronic Disease-suffer-Sleep Initiation and Maintenance Disorders', 'Obesity-increase-Wounds and Injuries', 'Lordosis-compensate-Kyphosis', 'Sarcopenia-involve-Mitochondrial Diseases', 'Pain-function-Fractures, Bone', 'Rhinitis, Allergic-show-Apnea', 'Sleep Wake Disorders-receive-Rhinitis, Allergic', 'Sleep Wake Disorders-receive-Asthma', 'Parkinson Disease-use-Dyskinesia, Drug-Induced', 'Parkinson Disease-use-Parkinson Disease, Secondary', 'Infections-explant-Heart Failure', 'Infections-relieve-Pain', 'Heart Failure-relieve-Pain', 'Infections-followed-Death', 'Death-followed-Hypoxia, Brain', 'Death-followed-Brain Diseases', 'Status Epilepticus-followed-Death', 'Seizures-identified-Status Epilepticus', 'Mitochondrial Diseases-associated-Retinal Degeneration', 'Retinal Degeneration-associated-Mitochondrial Diseases', 'Mitochondrial Diseases-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-Mitochondrial Diseases', 'Mitochondrial Diseases-connected-Neurodegenerative Diseases', 'Mitochondrial Diseases-connected-Alzheimer Disease', 'Neurodegenerative Diseases-characterized-Mitochondrial Diseases', 'Critical Illness-represent-Peripheral Arterial Disease', 'Calcinosis-lead-Atherosclerosis', 'Calcinosis-lead-Peripheral Arterial Disease', 'Calcinosis-increase-Death', 'Calcinosis-increase-Kidney Failure, Chronic', 'Atherosclerosis-increase-Death', 'Calcinosis-lead-Plaque, Atherosclerotic', 'Atherosclerosis-increase-Kidney Failure, Chronic', 'Peripheral Arterial Disease-increase-Death', 'Calcinosis-lead-Arterial Occlusive Diseases', 'Peripheral Arterial Disease-increase-Kidney Failure, Chronic', 'Sarcopenia-known-Muscle Weakness', 'Neoplasms-appearing-Kidney Diseases, Cystic', 'Kidney Diseases-sparing-Renal Insufficiency, Chronic', 'Seizures-present-Epilepsy', 'Heart Failure-include-Infections', 'Infections-followed-Venous Thromboembolism', 'Infections-redo-Death', 'Venous Thromboembolism-followed-Death', 'Renal Insufficiency, Chronic-identify-Kidney Failure, Chronic', 'Infections-cause-Communicable Diseases', 'Infections-sustain-Parasitic Diseases', 'Leishmaniasis-sustain-Parasitic Diseases', 'Optic Atrophy, Hereditary, Leber-applied-Glaucoma', 'Sarcopenia-produce-Muscle Weakness', 'Optic Atrophy, Hereditary, Leber-applied-Nervous System Diseases', 'Bone Neoplasms-masquerade-Pneumonia', 'Kidney Diseases-caused-Gout', 'Gout-caused-Kidney Diseases', 'Basal Ganglia Cerebrovascular Disease-activate-Atherosclerosis', 'Acute Kidney Injury-characterize-Renal Insufficiency', 'Neoplasms-reduced-Melanoma', 'Renal Insufficiency, Chronic-base-Albuminuria', 'Diabetes Mellitus-combined-Hypertension', 'Albuminuria-cause-Cardiovascular Diseases', 'Cardiovascular Diseases-linked-Neurodegenerative Diseases', 'Death-linked-Neurodegenerative Diseases', 'Albuminuria-related-Death', 'Albuminuria-play-Death', 'Wounds and Injuries-quantify-Frailty', 'Frailty-determine-Death', 'Encephalitis-follow-Meningitis', 'Diabetes Mellitus, Type 1-diagnosed-Insulin Resistance', 'Diabetes Mellitus-diagnosed-Insulin Resistance', 'Urinary Bladder Diseases-cause-Inflammatory Bowel Diseases', 'Neoplasms-viewed-Carcinogenesis', 'Neurodegenerative Diseases-accelerated-Brain Diseases', 'Brain Diseases-worsen-Hypertension', 'Brain Diseases-worsen-Heart Diseases', 'Brain Diseases-worsen-Atherosclerosis', 'Brain Diseases-worsen-Diabetes Mellitus', 'Nerve Degeneration-boost-Dementia', 'Nerve Degeneration-boost-Alzheimer Disease', 'Dyspnea-described-Heart Failure', 'Gastrointestinal Diseases-include-Chronic Disease', 'Gliosis-show-Hereditary Central Nervous System Demyelinating Diseases', 'Gliosis-show-Inflammation', 'Alzheimer Disease-linked-Dementia', 'Leukoencephalopathies-linked-Dementia', 'Neuralgia-caused-Blister', 'Neuralgia-described-Neoplasms', 'Pain-implicated-Neuralgia', 'Neuralgia-related-Sensation Disorders', 'Death-reduce-Pneumonia', 'Osteoporosis-prevent-Death', 'Fractures, Bone-protect-Fragile X Syndrome', 'Osteoporosis-take-Osteoporotic Fractures', 'Parkinson Disease-review-Delirium', 'Atrial Fibrillation-report-Pulmonary Embolism', 'Pulmonary Embolism-lead-Atrial Fibrillation', 'Pulmonary Embolism-share-Obesity', 'Pulmonary Embolism-share-Heart Failure', 'Atrial Fibrillation-lead-Pulmonary Embolism', 'Atrial Fibrillation-seen-Pulmonary Embolism', 'Neoplasms-provoke-Hemorrhage', 'Death-occur-Pancreatitis', 'HIV Infections-suffer-Death', 'Osteoporotic Fractures-treated-Fractures, Bone', 'Immunologic Deficiency Syndromes-play-Wernicke Encephalopathy', 'Immunologic Deficiency Syndromes-play-Nervous System Diseases', 'Death-observed-Neurodegenerative Diseases', 'Renal Insufficiency, Chronic-linked-Osteosarcoma', 'Obesity, Abdominal-predict-Atrial Fibrillation', 'Sepsis-precede-Brain Diseases', 'Weight Loss-cure-Diabetes Mellitus', 'Renal Insufficiency, Chronic-impact-Pulmonary Disease, Chronic Obstructive', 'Renal Insufficiency, Chronic-impact-Death', 'Atrial Fibrillation-present-Stroke', 'Atrial Fibrillation-present-Hemorrhage', 'Atrial Fibrillation-contribute-Stroke', 'Stroke-tend-Hemorrhage', 'Hemorrhage-fall-Cardiac Output, Low', 'Cardiac Output, Low-fall-Thromboembolism', 'Kidney Failure, Chronic-compare-Respiratory Insufficiency', 'Kidney Failure, Chronic-compare-Sepsis', 'Kidney Failure, Chronic-consider-Cardiac Complexes, Premature', 'Kidney Failure, Chronic-consider-Stroke', 'Renal Insufficiency, Chronic-consider-Cardiac Complexes, Premature', 'Renal Insufficiency, Chronic-consider-Stroke', 'Stroke-found-Renal Insufficiency, Chronic', 'Cardiac Complexes, Premature-found-Renal Insufficiency, Chronic', 'Death-show-Lung, Hyperlucent', 'Death-show-Pelvic Neoplasms', 'Atherosclerosis-compare-Diabetes Mellitus', 'Hypertension-increase-Heart Failure', 'Osteoarthritis-cause-Bone Cysts', 'Osteoarthritis-limit-Inflammation', 'Cardiovascular Abnormalities-drive-Neurodegenerative Diseases', 'Cardiovascular Abnormalities-observe-Multiple Sclerosis', 'Cardiovascular Abnormalities-evoke-Neurodegenerative Diseases', 'Neurodegenerative Diseases-observe-Multiple Sclerosis', 'Osteoporosis-featured-Bone Diseases, Metabolic', 'Neoplasms-lead-Seizures', 'Neoplasms-lead-Carcinogenesis', 'Seizures-lead-Carcinogenesis', 'Diabetes Mellitus-found-Diabetes Mellitus, Type 2', 'Asthma-cause-Pulmonary Disease, Chronic Obstructive', 'Pulmonary Disease, Chronic Obstructive-known-Asthma', 'Kidney Failure, Chronic-associated-Diabetes Mellitus, Type 2', 'Diabetes Mellitus, Type 2-associated-Kidney Failure, Chronic', 'Periodontitis-probe-Hemorrhage', 'Hip Dislocation, Congenital-associated-Infections', 'Infections-associated-Hip Dislocation, Congenital', 'Sarcopenia-admitted-Hip Fractures', 'Heart Failure-rise-Myocardial Infarction', 'Death-noted-Myocardial Infarction', 'Fatty Liver-include-Non-alcoholic Fatty Liver Disease', 'Carcinoma, Hepatocellular-include-Non-alcoholic Fatty Liver Disease', 'Anemia-caused-Inflammation', 'Inflammation-receive-Neoplasms', 'Postoperative Cognitive Complications-associated-Intraoperative Complications', 'Intraoperative Complications-associated-Postoperative Cognitive Complications', 'Postoperative Cognitive Complications-associated-Brain Injuries', 'Brain Injuries-associated-Postoperative Cognitive Complications', 'Ichthyosis, X-Linked-associated-Colitis, Ulcerative', 'Colitis, Ulcerative-associated-Ichthyosis, X-Linked', 'Death-compared-Atherosclerosis', 'Dementia-compared-Atherosclerosis', 'Lupus Erythematosus, Systemic-characterized-Kidney Diseases', 'Lupus Erythematosus, Cutaneous-describe-Inflammation', 'Asthma-referred-Panuveitis', 'Asthma-referred-Chorioretinitis', 'Chorioretinitis-centered-Macular Degeneration', 'Granuloma-centered-Macular Degeneration', 'Sarcoidosis-develop-Chronic Disease', 'Mitochondrial Diseases-converge-Idiopathic Pulmonary Fibrosis', 'Bacteremia-diagnosed-Rectal Neoplasms', 'Obesity-deepened-Cardiovascular Diseases', 'Obesity-deepened-Diabetes Mellitus', 'Death-deepened-Cardiovascular Diseases', 'Death-deepened-Diabetes Mellitus', 'Gait Disorders, Neurologic-identified-Musculoskeletal Diseases', 'Gait Disorders, Neurologic-identified-Vestibular Diseases', 'Arthritis-characterized-Inflammation', 'Arthritis-lead-Inflammation', 'Gout-identify-Tendinopathy', 'Gout-identify-Enthesopathy', 'Liver Diseases, Alcoholic-refer-Neurologic Manifestations', 'Liver Diseases, Alcoholic-refer-Liver Failure', 'Neurologic Manifestations-contribute-Liver Failure', 'Pneumonia-present-Fever', 'Pneumonia-develop-Cough', 'Pneumonia-develop-Pharyngeal Diseases', 'Stroke-follow-Thrombosis', 'Arterial Occlusive Diseases-follow-Thrombosis', 'Fever-develop-Cardiovascular Diseases', 'Parkinson Disease-include-Hallucinations', 'Cough-develop-Cardiovascular Diseases', 'Parkinson Disease-include-Chronobiology Disorders', 'Pharyngeal Diseases-develop-Cardiovascular Diseases', 'Obesity-increased-Chemical and Drug Induced Liver Injury', 'Non-alcoholic Fatty Liver Disease-increased-Chemical and Drug Induced Liver Injury', 'Dementia-experience-Chronic Disease', 'Dementia-experience-Death', 'Sarcopenia-attenuate-Muscular Diseases', 'Wounds and Injuries-suffer-Surgical Wound Infection', 'Angina Pectoris-experience-Myocardial Infarction', 'Hepatic Encephalopathy-associated-Death', 'Death-associated-Hepatic Encephalopathy', 'Vitamin A Deficiency-exacerbate-Memory Disorders', 'Vitamin A Deficiency-exacerbate-Alzheimer Disease', 'Alzheimer Disease-exacerbate-Memory Disorders', 'Vitamin A Deficiency-facilitate-Alzheimer Disease', 'Liver Failure, Acute-support-Chemical and Drug Induced Liver Injury', 'Diabetes Mellitus-serve-Diabetic Nephropathies', 'Obesity-promote-Metabolic Diseases', 'Spinal Diseases-fall-Cardiac Output, Low', 'Lordosis-reveal-Cardiac Output, Low', 'Tachycardia, Ventricular-decrease-Diabetes Mellitus', 'Tachycardia, Ventricular-decrease-Hyperglycemia', 'Memory Disorders-induced-Diabetes Mellitus', 'Death-associated-Arteriovenous Fistula', 'Arteriovenous Fistula-associated-Death', 'Osteoporosis-include-Communicable Diseases', 'Diabetes Mellitus-associated-Aortic Diseases', 'Aortic Diseases-associated-Diabetes Mellitus', 'Hip Fractures-include-Muscular Dystrophy, Emery-Dreifuss', 'Arthritis-damaged-Pain', 'Diabetes Mellitus-regarded-Fractures, Bone', 'Inflammation-regarded-Fractures, Bone', 'Neoplasms-live-Papillomavirus Infections', 'Thoracic Injuries-defined-Fractures, Bone', 'Thoracic Injuries-arise-Fractures, Bone', 'Rib Fractures-found-Thoracic Injuries', 'Neurodegenerative Diseases-examined-Parkinson Disease', 'Stomach Neoplasms-define-Adenocarcinoma', 'Stomach Neoplasms-define-Carcinoma, Signet Ring Cell', 'Stomach Neoplasms-define-Hodgkin Disease', 'Stomach Neoplasms-associated-Infections', 'Infections-associated-Stomach Neoplasms', 'Stomach Neoplasms-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-Stomach Neoplasms', 'Neoplasms-inhibit-Necrosis', 'Mitochondrial Diseases-contribute-Carcinogenesis', 'Muscular Diseases-identified-Death', 'Muscular Diseases-suffer-Wounds and Injuries', 'Sepsis-serve-Death', 'Delirium-act-Dementia', 'Urinary Incontinence-reduce-Death', 'Diabetes Mellitus-develop-Cardiovascular Diseases', 'Death-compare-Hypoglycemia', 'Obesity, Abdominal-associate-Chronic Disease', 'Chronic Disease-associate-Obesity, Abdominal', 'Obesity, Abdominal-control-Chronic Disease', 'Diabetes Mellitus-provide-Fractures, Bone', 'Parkinson Disease-evolve-Dementia', 'Neurodegenerative Diseases-produce-Parkinson Disease, Secondary', 'Diabetes Mellitus-avoid-Urinary Bladder Neck Obstruction', 'Hypotension-avoid-Urinary Bladder Neck Obstruction', 'Nocturia-explained-Urinary Bladder Diseases', 'Death-use-Heart Failure', 'Cardiovascular Diseases-use-Heart Failure', 'Cardiovascular Diseases-use-Myocardial Infarction', 'Fibrosis-increase-Arrhythmias, Cardiac', 'Arrhythmias, Cardiac-occur-Fibrosis', 'HIV Infections-control-AIDS Arteritis, Central Nervous System', 'Cardiac Output, Low-include-Chronic Disease', 'Cardiac Output, Low-associated-Obesity', 'Obesity-associated-Cardiac Output, Low', 'Muscular Diseases-occur-Chronic Disease', 'Muscular Diseases-occur-Cachexia', 'Muscular Diseases-occur-Sarcopenia', 'Breast Neoplasms-result-Anemia', 'Urinary Incontinence-complicate-Alzheimer Disease', 'Urinary Incontinence-complicate-Death', 'Pain-present-Hernia', 'Edema-present-Hernia', 'Gout-suppress-Inflammation', 'Renal Insufficiency, Chronic-suppress-Inflammation', 'Cardiovascular Diseases-suppress-Inflammation', 'Hip Fractures-assessed-Fractures, Bone', 'Hip Fractures-verified-Death', 'Fractures, Bone-verified-Death', 'Muscle Weakness-found-Heart Failure', 'Muscle Weakness-found-Neoplasms', 'Muscular Diseases-decrease-Heart Failure', 'Muscle Weakness-found-Renal Insufficiency', 'Communicable Diseases-associated-Muscle Weakness', 'Muscle Weakness-associated-Communicable Diseases', 'Hypoaldosteronism-considered-Hyponatremia', 'Hyponatremia-develop-Hypoaldosteronism', 'Diabetes Mellitus-associated-Intervertebral Disc Degeneration', 'Intervertebral Disc Degeneration-associated-Diabetes Mellitus', 'Osteomyelitis-occur-Infections', 'Clostridium Infections-present-Fever', 'Clostridium Infections-present-Diarrhea', 'Clostridium Infections-present-Abdominal Pain', 'Diabetes Mellitus-accelerate-Tuberculosis', 'Silicosis-impair-Tuberculosis', 'HIV Infections-impair-Tuberculosis', 'Diabetes Mellitus-impair-Tuberculosis', 'Pneumonia-investigate-Chest Pain', 'Tinnitus-include-Perceptual Disorders', 'Hyperacusis-include-Perceptual Disorders', 'Alzheimer Disease-diagnosed-Psychoses, Substance-Induced', 'Psychoses, Substance-Induced-Establish-Alzheimer Disease', 'Communicable Diseases-lessen-Prostatic Hyperplasia', 'Cardiac Output, Low-fall-Hemorrhage', 'Cardiac Output, Low-fall-Intracranial Hemorrhages', 'Dementia-promote-Alzheimer Disease', 'Alzheimer Disease-fit-Seizures', 'Alzheimer Disease-react-Dementia', 'Cardiac Output, Low-diagnose-Pulmonary Disease, Chronic Obstructive', 'Osteoporotic Fractures-manage-Neurologic Manifestations', 'Carcinoma, Squamous Cell-observed-Hantavirus Pulmonary Syndrome', 'Fibrosis-associated-Liver Diseases', 'Liver Diseases-associated-Fibrosis', 'Chemical and Drug Induced Liver Injury-undermine-Liver Failure', 'Metabolic Diseases-reduce-Fatty Liver', 'Pulmonary Disease, Chronic Obstructive-identified-Asthma', 'Laron Syndrome-protect-Neoplasms', 'Laron Syndrome-protect-Diabetes Mellitus', 'Dystonia-develop-Dementia', 'Infections-exert-Colitis', 'Diabetes Mellitus-link-Glucose Metabolism Disorders', 'Nerve Degeneration-involve-Motor Neuron Disease', 'Cardiovascular Diseases-prevent-Death', 'Myotonic Dystrophy-show-Melanoma', 'Myotonic Dystrophy-diagnosed-Dysplastic Nevus Syndrome', 'Infections-display-Weight Loss', 'Weight Loss-display-Infections', 'Atrophy-associated-Fatigue', 'Fatigue-associated-Atrophy', 'Genetic Diseases, Inborn-caused-Peroxisomal Disorders', 'Hypertension-observed-Obesity', 'Mitochondrial Diseases-reported-Bloom Syndrome', 'Bloom Syndrome-considered-Mitochondrial Diseases', 'Genetic Diseases, Inborn-characterised-Immunologic Deficiency Syndromes', 'Genetic Diseases, Inborn-characterised-Neurodegenerative Diseases', 'Diabetes Mellitus-increase-Postoperative Cognitive Complications', 'Leukemia, Lymphocytic, Chronic, B-Cell-affect-Lymphoma', 'Leukemia, Lymphocytic, Chronic, B-Cell-present-Neoplasms', 'Inflammation-contain-Neoplasms', 'Leukemia-affect-Lymphoma', 'Respiratory Distress Syndrome-affect-Death', 'Critical Illness-affect-Death', 'Calcinosis-increased-Metabolic Syndrome', 'Calcinosis-increased-Diabetes Mellitus, Type 2', 'Calcinosis-increased-Dementia', 'Calcinosis-increased-Stroke', 'Calcinosis-increased-Ischemia', 'Calcinosis-increased-Renal Insufficiency', 'Paraproteinemias-begin-Leukemia', 'Paraproteinemias-begin-Multiple Myeloma', 'Heart Arrest-associated-Acute Kidney Injury', 'Acute Kidney Injury-associated-Heart Arrest', 'Retinal Arterial Macroaneurysm-exist-Hypertension', 'Intracranial Aneurysm-exist-Hypertension', 'Neurodegenerative Diseases-characterized-Motor Neuron Disease', 'Metabolic Syndrome-height-Hypertension', 'Parkinson Disease-consider-Osteoporosis', 'Musculoskeletal Pain-consider-Osteoporosis', 'Hepatitis B, Chronic-prevent-Death', 'Fibrosis-prevent-Death', 'End Stage Liver Disease-prevent-Death', 'Carcinoma, Hepatocellular-prevent-Death', 'Fibrosis-develop-Carcinoma, Hepatocellular', 'Diabetic Neuropathies-include-Peripheral Nervous System Diseases', 'Pain-relieved-Dyspnea', 'Hypotension-assess-Diabetes Mellitus', 'Sleep Initiation and Maintenance Disorders-associated-Seizures', 'Seizures-associated-Sleep Initiation and Maintenance Disorders', 'Infections-treat-Gastroenteritis', 'Deglutition Disorders-associated-Spinocerebellar Ataxias', 'Spinocerebellar Ataxias-associated-Deglutition Disorders', 'Diabetes Mellitus-contribute-Deglutition Disorders', 'HIV Infections-ascribed-Inflammation', 'Acquired Immunodeficiency Syndrome-ascribed-Inflammation', 'Inflammation-lead-Joint Diseases', 'Diabetes Mellitus-experience-Ovarian Diseases', 'Osteoporotic Fractures-stratify-Osteoarthritis', 'Hypothalamic Diseases-disrupt-Diabetes Mellitus', 'Nervous System Diseases-evaluated-Kidney Diseases', 'Neoplasms-provide-Inflammation', 'Atrial Fibrillation-result-Hemorrhage', 'Venous Thromboembolism-result-Hemorrhage', 'Seizures-associated-Memory Disorders', 'Memory Disorders-associated-Seizures', 'Hallucinations-include-Epilepsy', 'Neoplasms-examine-Alzheimer Disease', 'Hyperalgesia-described-Pain', 'Osteoporosis-known-Neurodegenerative Diseases', 'Osteoporosis-known-Fractures, Bone', 'Neurodegenerative Diseases-known-Fractures, Bone', 'Sarcopenia-improve-Stomach Neoplasms', 'Immunologic Deficiency Syndromes-diagnosed-Erectile Dysfunction', 'Death-increasing-Kidney Neoplasms', 'Neoplasms-transformed-Death', 'Ochronosis-affected-Sleep Initiation and Maintenance Disorders', 'Alkaptonuria-demonstrate-Oculocerebrorenal Syndrome', 'Headache Disorders, Secondary-improve-Weight Loss', 'Renal Insufficiency, Chronic-predict-Hyperuricemia', 'Renal Insufficiency, Chronic-predict-Hypertension', 'Hyperuricemia-predict-Hypertension', 'Sleep Initiation and Maintenance Disorders-stay-Diabetes Mellitus', 'Fatigue-co-occur-Pain', 'Stomach Neoplasms-cause-Osteoporosis', 'Stomach Neoplasms-cause-Protein-Energy Malnutrition', 'Neoplasms-cause-Osteoporosis', 'Neoplasms-cause-Protein-Energy Malnutrition', 'Fistula-experience-Breast Neoplasms', 'Hemostatic Disorders-suspected-Hemorrhage', 'Hemostatic Disorders-avoid-Hemorrhage', 'Hemostatic Disorders-suspected-Thrombosis', 'Hemostatic Disorders-avoid-Thrombosis', 'Heterotaxy Syndrome-derived-Cardiovascular Diseases', 'Death-use-Meningitis', 'Death-determined-Meningitis', 'Death-survive-Meningitis', 'Death-related-Meningitis', 'Sarcopenia-assessed-Bone Diseases, Metabolic', 'Atherosclerosis-thicken-Infections', 'Bone Diseases, Metabolic-associated-Pulmonary Disease, Chronic Obstructive', 'Pulmonary Disease, Chronic Obstructive-associated-Bone Diseases, Metabolic', 'Hypertrophy-result-Hypertension', 'Cross Infection-leading-Gastroenteritis', 'Gastroenteritis-followed-Diarrhea', 'Trochlear Nerve Diseases-associated-Death', 'Death-associated-Trochlear Nerve Diseases', 'Emphysema-report-Idiopathic Pulmonary Fibrosis', 'Pulmonary Fibrosis-predominate-Emphysema', 'Heart Arrest-suppress-Neoplasms', 'Retinal Neoplasms-prevent-Inflammation', 'Microcephaly-include-Autoimmune Diseases', 'Microcephaly-reported-Communicable Diseases', 'Autoimmune Diseases-reported-Communicable Diseases', 'Leukemia, Myeloid, Acute-present-Infections', 'Arrhythmias, Cardiac-measured-Ventricular Premature Complexes', 'Abdominal Pain-develop-Thrombocytopenia', 'Cold Injury-increase-Arrhythmias, Cardiac', 'Albuminuria-proposed-Atherosclerosis', 'Infections-require-Arthritis, Rheumatoid', 'Ovarian Diseases-include-Amenorrhea', 'Cushing Syndrome-include-Amenorrhea', 'Hypothyroidism-include-Amenorrhea', 'Amenorrhea-ameliorate-Alzheimer Disease', 'Delirium-described-Liver Failure, Acute', 'Delirium-described-Dementia', 'Delirium-described-End Stage Liver Disease', 'Multiple Organ Failure-superimposed-Delirium', 'Delirium-resemble-Kidney Failure, Chronic', 'Delirium-superimposed-Kidney Failure, Chronic', 'Dementia-resemble-Kidney Failure, Chronic', 'Crohn Disease-account-Neoplasms', 'Death-related-Inflammatory Bowel Diseases', 'Neoplasms-seen-Neurodegenerative Diseases', 'Brain Neoplasms-impact-Glioma', 'Brain Neoplasms-regulate-Neoplasms', 'Neoplasms-impact-Glioma', 'Blood Protein Disorders-rescue-Nematode Infections', 'Renal Insufficiency, Chronic-admitted-Infections', 'Muscular Diseases-considered-Sarcopenia', 'Brain Infarction-associated-Stroke', 'Stroke-associated-Brain Infarction', 'Intracranial Hemorrhages-treated-Cerebral Infarction', 'Hemorrhage-treated-Cerebral Infarction', 'Cerebrovascular Disorders-provide-Stroke', 'Stroke-indicated-Brain Infarction', 'Neoplasms-derived-Carcinogenesis', 'Neoplasms-extrapolated-Endometrial Neoplasms', 'Carcinogenesis-extrapolated-Endometrial Neoplasms', 'Endometrial Neoplasms-extrapolated-Neoplasms', 'Dementia-represent-Chronic Disease', 'Dementia-control-Death', 'Alzheimer Disease-control-Death', 'Musculoskeletal Diseases-induced-Hypertension', 'Sleep Wake Disorders-investigate-Adrenal Insufficiency', 'Hypertrophy-promote-Osteogenesis Imperfecta', 'Death-prompt-Hip Fractures', 'Lipodystrophy-include-Metabolic Diseases', 'Hip Fractures-integrate-Death', 'Cataract-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-Cataract', 'Prostatic Neoplasms-experience-Neoplasms', 'Hypertension-occur-Hemophilia A', 'Acute Kidney Injury-differentiate-Renal Insufficiency', 'Epilepsy-fit-Seizures', 'Pneumococcal Infections-remain-Tuberculosis', 'Respiratory Tract Diseases-generate-Death', 'Hantavirus Pulmonary Syndrome-generate-Death', 'Neoplasms-collected-Endometrial Neoplasms', 'Stroke-defined-Dementia', 'Dementia-defined-Stroke', 'Respiration Disorders-increase-Death', 'Hip Fractures-prescribe-Osteoporosis', 'Brain Injuries-result-Wounds and Injuries', 'Immunologic Deficiency Syndromes-suggest-Death', 'Immunologic Deficiency Syndromes-produce-Hypothalamic Neoplasms', 'Urinary Tract Infections-use-Bacteriuria', 'Urinary Tract Infections-cause-Bacteriuria', 'Urinary Tract Infections-use-Infections', 'Constipation-reduce-Diabetes Mellitus', 'Constipation-reduce-Osteoarthritis', 'Headache-classified-Headache Disorders', 'Parotitis-result-Skin Diseases', 'Fever-present-Tachypnea', 'Urinary Incontinence-use-Parkinson Disease, Secondary', 'Urinary Incontinence-examine-Parkinson Disease, Secondary', 'Urinary Incontinence-related-Nervous System Diseases', 'Death-related-Nervous System Diseases', 'Urinary Incontinence-related-Parkinson Disease', 'Urinary Incontinence-related-Nerve Degeneration', 'Death-related-Parkinson Disease', 'Death-related-Nerve Degeneration', 'Death-related-Abnormalities, Drug-Induced', 'Infertility, Male-influence-Death', 'Wounds and Injuries-combine-Pain', 'Wounds and Injuries-combine-Delirium', 'Wounds and Injuries-combine-Dementia', 'Respiratory Tract Diseases-include-Death', 'Scoliosis-correlated-Pain', 'Scoliosis-correlated-Low Back Pain', 'Neoplasms-register-Leukemia, Lymphocytic, Chronic, B-Cell', 'Joint Diseases-include-Osteoarthritis', 'Pain-include-Osteoarthritis', 'Obesity-develop-Osteoarthritis', 'Pneumococcal Infections-improve-Death', 'Sarcopenia-reflect-Muscle Weakness', 'Prostatitis-describe-Prostatic Hyperplasia', 'Sarcopenia-treat-Respiratory Tract Diseases', 'Hyperbilirubinemia-identified-Death', 'Endometrial Hyperplasia-lie-Endometrial Neoplasms', 'Neoplasms-divide-Death', 'Death-decrease-Esophageal Neoplasms', 'Death-decrease-Stomach Neoplasms', 'Death-decrease-Leukemia, Myelogenous, Chronic, BCR-ABL Positive', 'Neoplasms-correlated-Leukemia, Myeloid, Acute', 'Leukemia, Myeloid, Acute-assess-Seizures', 'Acute Coronary Syndrome-consist-Myocardial Infarction', 'Hematologic Diseases-distinguish-Myelodysplastic Syndromes', 'Acute Coronary Syndrome-consist-Angina, Stable', 'Leukemia, Myeloid-clarify-Anemia', 'Myelodysplastic Syndromes-clarify-Anemia', 'Wounds and Injuries-result-Osteochondritis', 'Hemangiosarcoma-present-Neoplasms', 'Alzheimer Disease-include-Craniocerebral Trauma', 'Chronic Disease-use-Neoplasms', 'Chronic Disease-explore-Neoplasms', 'Pneumonia-rank-Death', 'Chronic Disease-use-HIV Infections', 'Chronic Disease-use-Acquired Immunodeficiency Syndrome', 'Chronic Disease-use-Diabetes Mellitus', 'Chronic Disease-explore-Diabetes Mellitus', 'Multiple Myeloma-affect-Death', 'Edema-occur-Arthritis, Rheumatoid', 'Stroke-present-Cerebral Small Vessel Diseases', 'Heart Failure-influence-Heart Diseases', 'Arthritis-associated-Adrenal Insufficiency', 'Adrenal Insufficiency-associated-Arthritis', 'Heart Failure-classified-Cardiomyopathy, Dilated', 'Heart Failure-classified-Cardiomyopathy, Hypertrophic', 'Death-found-Neck Pain', 'Carotid Stenosis-known-Stroke', 'Carotid Stenosis-known-Death', 'Carotid Artery Diseases-reduce-Stroke', 'Stroke-reduce-Heart Diseases', 'Death-attributed-Renal Insufficiency, Chronic', 'Albuminuria-precede-Renal Insufficiency', 'Albuminuria-precede-Fanconi Syndrome', 'Albuminuria-precede-Anemia, Sickle Cell', 'Hypertension-control-Diabetes Mellitus', 'Parkinson Disease-documented-Heart Diseases', 'Heart Diseases-occur-Parkinson Disease', 'Parkinson Disease-occur-Heart Diseases', 'Heart Failure-worked-Atrial Fibrillation', 'Death-worked-Atrial Fibrillation', 'Atrial Fibrillation-worked-Death', 'Sarcopenia-configure-Death', 'Inflammation-result-Demyelinating Diseases', 'Inflammation-result-Communicable Diseases', 'Demyelinating Diseases-result-Communicable Diseases', 'Chronic Kidney Disease-Mineral and Bone Disorder-replaced-Renal Insufficiency, Chronic', 'Chronic Kidney Disease-Mineral and Bone Disorder-replaced-Bone Diseases', 'Chronic Kidney Disease-Mineral and Bone Disorder-replaced-Vascular Calcification', 'Chronic Kidney Disease-Mineral and Bone Disorder-include-Vascular Calcification', 'Chronic Kidney Disease-Mineral and Bone Disorder-include-Bone Diseases', 'Vascular Calcification-include-Renal Insufficiency, Chronic', 'Torsades de Pointes-associated-Arrhythmias, Cardiac', 'Arrhythmias, Cardiac-associated-Torsades de Pointes', 'Bone Diseases-include-Renal Insufficiency, Chronic', 'Pain-associated-Neoplasms', 'Neoplasms-associated-Pain', 'Inflammation-increase-Death', 'Wounds and Injuries-improve-Fractures, Bone', 'Proteostasis Deficiencies-correct-Immunologic Deficiency Syndromes', 'Immunologic Deficiency Syndromes-correct-Huntington Disease', 'Constipation-treat-Delirium', 'Musculoskeletal Diseases-represent-Scoliosis', 'Heart Diseases-related-Opportunistic Infections', 'Heart Diseases-related-Cardiomyopathies', 'Heart Diseases-related-Pericarditis', 'Heart Diseases-related-Pulmonary Arterial Hypertension', 'Inflammation-accompany-Obesity', 'Disorders of Excessive Somnolence-show-Alzheimer Disease', 'Pneumonia, Aspiration-mailed-Pneumonia', 'Kidney Diseases-found-Wounds and Injuries', 'Multiple Organ Failure-lead-Cardiovascular Diseases', 'Multiple Organ Failure-lead-Kidney Diseases', 'Multiple Organ Failure-lead-Fibrosis', 'Multiple Organ Failure-alter-Idiopathic Pulmonary Fibrosis', 'Hip Fractures-repair-Delirium', 'Hip Fractures-experienced-Headache Disorders, Secondary', 'Hypotension-define-Heart Failure', 'Venous Thrombosis-involve-Blood Coagulation Disorders', 'Venous Thrombosis-understood-Blood Coagulation Disorders', 'Cerebrovascular Disorders-followed-Calcinosis', 'Cardiac Output, Low-decrease-Seizures', 'Infections-account-Epilepsy', 'Infections-account-Neurocysticercosis', 'Renal Tubular Transport, Inborn Errors-result-Drug-Related Side Effects and Adverse Reactions', 'Inflammation-promote-Sarcopenia', 'HIV Infections-considered-Communicable Diseases', 'HIV Infections-transform-Inflammation', 'Infections-transform-Inflammation', 'Kidney Failure, Chronic-differ-Renal Insufficiency', 'HIV Infections-treat-Infections', 'Anemia-fail-Death', 'Anemia-affect-Death', 'Death-affect-Anemia, Macrocytic', 'Drug-Related Side Effects and Adverse Reactions-demonstrate-Renal Insufficiency, Chronic', 'Joint Diseases-describe-Death', 'Hemolytic-Uremic Syndrome-lead-Inflammation', 'Sexual Dysfunction, Physiological-help-Hallucinations', 'Vestibular Diseases-improve-Benign Paroxysmal Positional Vertigo', 'Ischemia-include-Brain Diseases', 'Brain Injuries, Traumatic-include-Brain Diseases', 'Epilepsy-noted-Breast Neoplasms, Male', 'Breast Neoplasms, Male-noted-Craniocerebral Trauma', 'Multiple Sclerosis-ensue-Neurodegenerative Diseases', 'Migraine Disorders-result-Epilepsy', 'Multiple Sclerosis-ensue-Nerve Degeneration', 'Multiple Sclerosis-explain-Neurodegenerative Diseases', 'Demyelinating Diseases-ensue-Neurodegenerative Diseases', 'Demyelinating Diseases-ensue-Nerve Degeneration', 'Cerebral Small Vessel Diseases-share-Multiple Sclerosis', 'Cerebral Small Vessel Diseases-share-Demyelinating Diseases', 'Multiple Sclerosis-related-Neurodegenerative Diseases', 'Multiple Sclerosis-influence-Neurodegenerative Diseases', 'Cerebral Small Vessel Diseases-influence-Neurodegenerative Diseases', 'Cerebral Small Vessel Diseases-address-Multiple Sclerosis', 'Cerebral Small Vessel Diseases-contribute-Hypoxia', 'Cerebral Small Vessel Diseases-reduced-Multiple Sclerosis', 'Hip Fractures-treated-Postpartum Hemorrhage', 'Fractures, Bone-lead-Hypercalcemia', 'Pain-lead-Hypercalcemia', 'Alzheimer Disease-involved-Neurodegenerative Diseases', 'Parkinson Disease-remain-Nervous System Diseases', 'Myelodysplastic Syndromes-carry-Death', 'Myelodysplastic Syndromes-driven-Cell Transformation, Viral', 'Death-driven-Cell Transformation, Viral', 'Osteoporosis-associated-Pulmonary Fibrosis', 'Pulmonary Fibrosis-associated-Osteoporosis', 'Pulmonary Fibrosis-affect-Osteoporosis', 'Retinal Vein Occlusion-find-Hypertension', 'Retinal Vein Occlusion-find-Stroke', 'Retinal Vein Occlusion-find-Hypercholesterolemia', 'Hypertension-show-Retinal Vein Occlusion', 'Immunologic Deficiency Syndromes-know-Hypogonadism', 'Hypogonadism-know-Sarcopenia', 'Hypogonadism-attenuate-Sarcopenia', 'Heart Diseases-decline-Death', 'Neoplasms-decline-Death', 'Riboflavin Deficiency-associated-Malabsorption Syndromes', 'Malabsorption Syndromes-associated-Riboflavin Deficiency', 'Cerebral Amyloid Angiopathy-recognize-Cerebral Hemorrhage', 'Death-attributed-Asthma', 'Urinary Incontinence-fall-Hearing Loss', 'Cardiac Output, Low-fall-Hearing Loss', 'Mobility Limitation-examine-Urinary Incontinence', 'Intracranial Aneurysm-determine-Rupture', 'Rupture-determine-Intracranial Aneurysm', 'Intracranial Aneurysm-experience-Subarachnoid Hemorrhage', 'Subarachnoid Hemorrhage-yield-Rupture', 'Mitochondrial Diseases-involved-Cachexia', 'Mitochondrial Diseases-feature-Cachexia', 'Stomach Neoplasms-associated-Cachexia', 'Cachexia-associated-Stomach Neoplasms', 'Fractures, Bone-take-Postpartum Hemorrhage', 'Anemia-associated-Fractures, Bone', 'Fractures, Bone-associated-Anemia', 'Fractures, Bone-associated-Postpartum Hemorrhage', 'Postpartum Hemorrhage-associated-Fractures, Bone', 'Respiratory Insufficiency-suffer-Lung Diseases', 'Respiratory Insufficiency-hospitalized-Neoplastic Syndromes, Hereditary', 'Pneumococcal Infections-confirm-Pneumonia', 'Pneumonia-related-Death', 'Hip Fractures-undergo-Death', 'Memory Disorders-evaluate-Craniocerebral Trauma', 'Vision Disorders-play-Alzheimer Disease', 'Alzheimer Disease-regarded-Arteriosclerosis', 'Heart Failure-induced-Hypertension', 'Heart Failure-prevent-Cardiomegaly', 'Sarcopenia-used-Muscle Weakness', 'Sarcopenia-examine-Muscle Weakness', 'Hypertension-treat-Dementia', 'Thyroid Neoplasms-comprise-Thyroid Carcinoma, Anaplastic', 'Hyperparathyroidism-considered-Thyroid Diseases', 'Ataxia Telangiectasia-diagnose-Hypogonadism', 'Hyperparathyroidism-occur-Thyroid Neoplasms', 'Headache Disorders, Secondary-represent-Hypogonadism', 'Multiple Myeloma-provide-Kartagener Syndrome', 'Hyalinosis, Systemic-show-Glomerulonephritis', 'Hyalinosis, Systemic-induce-Glomerulonephritis', 'Carcinoma, Pancreatic Ductal-evaluate-Neoplasms', 'Calcinosis-associated-Hypercholesterolemia', 'Hypercholesterolemia-associated-Calcinosis', 'Calcinosis-associated-Genetic Diseases, Inborn', 'Genetic Diseases, Inborn-associated-Calcinosis', 'Aneurysm-matched-Death', 'Neoplasms-include-Respiratory Tract Diseases', 'Idiopathic Pulmonary Fibrosis-include-Respiratory Tract Diseases', 'Nervous System Diseases-followed-Cardiovascular Diseases', 'Ischemia-reduce-Acute Coronary Syndrome', 'Acute Coronary Syndrome-increase-Hemorrhage', 'Pancreatitis-consist-Hemorrhage', 'Pancreatitis-consist-Inflammation', 'Pancreatitis-consist-Fibrosis', 'Pancreatitis-consist-Carcinoma, Acinar Cell', 'Pancreatitis-cause-Carcinoma, Acinar Cell', 'Pancreatitis-cause-Retinal Degeneration', 'Sarcopenia-hypothesize-Death', 'Sarcopenia-hypothesize-Wounds and Injuries', 'Death-hypothesize-Wounds and Injuries', 'Huntington Disease-result-Neurodegenerative Diseases', 'Osteosarcoma-differentiate-Pelvic Neoplasms', 'Wounds and Injuries-include-Heart Diseases', 'Hip Dislocation, Congenital-undergo-Seizures', 'Hip Dislocation, Congenital-include-Seizures', 'Diabetes Mellitus-act-Glucose Metabolism Disorders', 'Atherosclerosis-reduce-Renal Insufficiency, Chronic', 'Hemorrhage-occur-Death', 'Soft Tissue Injuries-quantify-Muscular Diseases', 'Soft Tissue Injuries-quantify-Inflammation', 'Death-compare-Airway Obstruction', 'Cockayne Syndrome-seen-Mitochondrial Diseases', 'Xeroderma Pigmentosum-seen-Mitochondrial Diseases', 'Shock-protect-Fever', 'Shock-protect-Hypoxia', 'Genetic Diseases, Inborn-include-Neurodegenerative Diseases', 'Pain-improve-Liver Neoplasms', 'Muscle Spasticity-improve-Liver Neoplasms', 'Tremor-improve-Liver Neoplasms', 'Muscle Rigidity-improve-Liver Neoplasms', 'Parkinson Disease-improve-Liver Neoplasms', 'Alzheimer Disease-diminish-Psychomotor Agitation', 'Ventricular Fibrillation-related-Bradycardia', 'Leiomyoma-report-Neoplasms', 'Neoplasms-represent-Ovarian Neoplasms', 'Ischemia-result-Colonic Neoplasms', 'Ischemia-result-Arterial Occlusive Diseases', 'Thrombosis-result-Colonic Neoplasms', 'Embolism-result-Colonic Neoplasms', 'Colonic Neoplasms-result-Arterial Occlusive Diseases', 'Lung Neoplasms-experience-Drug-Related Side Effects and Adverse Reactions', 'Atherosclerosis-arise-Rupture', 'Toothache-used-Oral Ulcer', 'Nerve Degeneration-cause-Crystal Arthropathies', 'Crystal Arthropathies-lead-Vertigo', 'Alzheimer Disease-reported-Neurotoxicity Syndromes', 'Death-underlie-Cardiovascular Diseases', 'Infections-happen-Death', 'Infections-underlie-Cardiovascular Diseases', 'Obesity-base-Ataxia', 'Cerebral Infarction-include-Delirium', 'Neoplasms-related-Hip Fractures', 'Femoral Neck Fractures-related-Death', 'Ossification of Posterior Longitudinal Ligament-predict-Death', 'Keratosis, Actinic-associated-Skin Neoplasms', 'Skin Neoplasms-associated-Keratosis, Actinic', 'Hip Fractures-suffer-Death', 'Osteoarthritis-examine-Arthritis', 'Parkinson Disease-threaten-Sensation Disorders', 'Death-find-Diabetes Mellitus', 'Death-find-Heart Diseases', 'Pain-reduce-Fractures, Bone', 'Pain-promote-Fractures, Bone', 'Malnutrition-characterized-Sarcopenia', 'Osteoporosis-contribute-Fractures, Bone', 'Osteoporosis-contribute-Hip Fractures', 'Diabetes Mellitus-compare-Obesity', 'Inflammation-play-Brain Damage, Chronic', 'Inflammation-play-Brain Ischemia', 'Inflammation-demonstrate-Stroke', 'Brain Damage, Chronic-demonstrate-Stroke', 'Brain Ischemia-demonstrate-Stroke', 'Infarction-reduce-Brain Ischemia', 'Neurologic Manifestations-reduce-Brain Ischemia', 'Stroke-associated-Splenic Diseases', 'Splenic Diseases-associated-Stroke', 'Stroke-reverse-Splenic Diseases', 'Hematologic Neoplasms-progress-Leukemia, Myeloid, Acute', 'Headache-induce-Cerebral Infarction', 'Hypotension-induce-Cerebral Infarction', 'Gait Disorders, Neurologic-result-Wounds and Injuries', 'Ataxia-associated-Dementia', 'Dementia-associated-Ataxia', 'Gait Disorders, Neurologic-associated-Dementia', 'Dementia-associated-Gait Disorders, Neurologic', 'Death-understand-Inflammation', 'Melanoma-remain-Communicable Diseases', 'Alzheimer Disease-consist-Dementia', 'Hypotension-include-Kidney Calculi', 'Melanoma-demonstrate-Neoplasms', 'Late Onset Disorders-trigger-Parkinson Disease', 'Crohn Disease-followed-Neoplasms', 'Neoplasms-discussed-Obesity', 'Subarachnoid Hemorrhage-provide-Aneurysm', 'Cardiovascular Abnormalities-notice-Subarachnoid Hemorrhage', 'Neurologic Manifestations-identify-Neoplasms', 'Nocturia-examine-Sleep Wake Disorders', 'Arthritis, Rheumatoid-remain-Inflammation', 'Coronary Artery Disease-improve-Angina, Stable', 'Obesity-compare-Fractures, Bone', 'Obesity-increase-Fractures, Bone', 'Fractures, Bone-linked-Death', 'Infections-respond-Communicable Diseases', 'Asthma-differentiate-Pulmonary Disease, Chronic Obstructive', 'Prostatic Neoplasms-improve-Sexual Dysfunction, Physiological', 'Carcinoma, Squamous Cell-outweight-Salivary Gland Neoplasms', 'Carcinoma, Squamous Cell-outweight-Neoplasms', 'Death-result-Necrosis', 'Carcinoma, Squamous Cell-represent-Lingual Thyroid', 'Status Epilepticus-identified-Cerebrovascular Disorders', 'Parkinson Disease-diagnosed-Movement Disorders', 'Parkinson Disease-diagnosed-Parkinson Disease, Secondary', 'Movement Disorders-diagnosed-Parkinson Disease', 'Movement Disorders-diagnosed-Parkinson Disease, Secondary', 'Atrial Fibrillation-lead-Gastrointestinal Diseases', 'Gastrointestinal Diseases-include-Fistula', 'Gastrointestinal Diseases-include-Gastroparesis', 'Gastrointestinal Diseases-include-Ulcer', 'Intervertebral Disc Degeneration-linked-Low Back Pain', 'Fractures, Bone-related-Cardiac Output, Low', 'Diabetes Mellitus-related-Cardiac Output, Low', 'Fractures, Bone-increased-Diabetes Mellitus', 'Hip Fractures-increased-Diabetes Mellitus', 'Cardiac Output, Low-increased-Diabetes Mellitus', 'Spinal Cord Injuries-base-Spinal Injuries', 'Endocarditis-associated-Colonic Neoplasms', 'Colonic Neoplasms-associated-Endocarditis', 'Infections-defined-Fever', 'Infections-compared-Fever', 'Neuroblastoma-used-Parkinson Disease', 'Neuroblastoma-study-Parkinson Disease', 'Weight Loss-implicated-Breast Neoplasms', 'Delirium-observed-Ischemia', 'Death-receive-Pain', 'Aortic Valve Stenosis-associated-Myocardial Infarction', 'Myocardial Infarction-associated-Aortic Valve Stenosis', 'Heart Failure-caused-Coronary Artery Disease', 'Neoplasms-include-Ovarian Diseases', 'Obesity-increase-Neurodegenerative Diseases', 'Dyspnea-include-Hypotension', 'Dyspnea-include-Muscle Weakness', 'Breast Neoplasms-classify-Neoplasms', 'Urinary Bladder Diseases-result-Infections', 'Urinary Bladder Diseases-result-Renal Insufficiency, Chronic', 'Machado-Joseph Disease-created-Parkinson Disease', 'Machado-Joseph Disease-created-Alzheimer Disease', 'Adenocarcinoma-lack-Neoplasms', 'Bone Neoplasms-translate-Kyphosis', 'Chronic Disease-focuss-Inflammation', 'Delirium-include-Postoperative Complications', 'Sleep Initiation and Maintenance Disorders-form-Neoplasms', 'Osteoarthritis-cause-Gait Disorders, Neurologic', 'Drug-Related Side Effects and Adverse Reactions-caused-Inflammation', 'Obesity-live-Osteoarthritis', 'Leukoencephalopathies-survive-Stroke', 'Muscle Weakness-lead-Fractures, Bone', 'Acidosis-associated-Renal Insufficiency', 'Renal Insufficiency-associated-Acidosis', 'Acidosis-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-Acidosis', 'Heart Failure-enrol-Pulmonary Edema', 'Cardiomyopathy, Hypertrophic-recognized-Airway Obstruction', 'Weight Loss-determined-Malnutrition', 'Cholecystitis, Acute-associated-Death', 'Death-associated-Cholecystitis, Acute', 'Cerebral Hemorrhage-related-Hypertension', 'Diabetes Mellitus-undergo-Albuminuria', 'Renal Insufficiency, Chronic-undergo-Albuminuria', 'Death-attributed-Sepsis', 'Inflammation-modulate-Death', 'Arbovirus Infections-added-Death', 'Respiratory Tract Infections-increase-Death', 'Malnutrition-increase-Death', 'Death-emerge-Neoplasms', 'Death-emerge-Coronary Artery Disease', 'Death-emerge-Fibrosis', 'Death-emerge-Alzheimer Disease', 'Enteritis-vary-Death', 'Diarrhea-vary-Death', 'Pneumococcal Infections-vary-Death', 'Respiratory Tract Infections-vary-Death', 'Death-decline-Acquired Immunodeficiency Syndrome', 'Death-decline-Malaria', 'Malaria-remain-Death', 'Aneuploidy-contribute-Inflammation', 'Neoplasms-lead-Immunologic Deficiency Syndromes', 'Immunologic Deficiency Syndromes-lead-Chronic Disease', 'Pain-used-Neuralgia', 'Cardiovascular Diseases-remain-Diabetes Mellitus', 'Sensation Disorders-limited-Kidney Diseases', 'Uveitis-followed-Uveomeningoencephalitic Syndrome', 'Hyperuricemia-associated-Leg Injuries', 'Leg Injuries-associated-Hyperuricemia', 'Heart Failure-demask-Hypertension', 'Ischemia-taken-Diabetes Mellitus', 'Acute Kidney Injury-taken-Diabetes Mellitus', 'Hypotension, Orthostatic-occur-Renal Insufficiency, Chronic', 'Hypotension, Orthostatic-occur-Cardiovascular Diseases', 'Hemorrhage-show-Carcinoma, Hepatocellular', 'Macular Degeneration-associated-Glycogen Storage Disease Type II', 'Glycogen Storage Disease Type II-associated-Macular Degeneration', 'Macular Degeneration-include-Vision Disorders', 'Arthritis, Rheumatoid-manage-Edema', 'Pulmonary Disease, Chronic Obstructive-diagnosed-Erectile Dysfunction', 'Polyuria-associated-Nocturia', 'Nocturia-associated-Polyuria', 'Urinary Incontinence-associated-Polyuria', 'Polyuria-associated-Urinary Incontinence', 'Stroke-achieve-Atrial Fibrillation', 'Atrial Fibrillation-denied-Hemorrhage', 'Osteoarthritis-show-Pain', 'Atrial Premature Complexes-associated-Atrial Fibrillation', 'Atrial Fibrillation-associated-Atrial Premature Complexes', 'Food Hypersensitivity-show-Drug Hypersensitivity', 'Acute Kidney Injury-lead-Kidney Diseases', 'Hearing Loss-associated-Death', 'Death-associated-Hearing Loss', 'Hearing Loss-live-Death', 'Kidney Diseases-indicate-Inflammation', 'Kidney Diseases-indicate-Wounds and Injuries', 'Sleep Wake Disorders-define-Hypoxia', 'Sleep Wake Disorders-use-Hypoxia', 'Inflammation-trigger-Glucose Metabolism Disorders', 'HIV Infections-trigger-Glucose Metabolism Disorders', 'Erectile Dysfunction-associated-Sleep Wake Disorders', 'Sleep Wake Disorders-associated-Erectile Dysfunction', 'Hypoxia-associated-Erectile Dysfunction', 'Erectile Dysfunction-associated-Hypoxia', 'Disease-cause-Vision Disorders', 'Asthma-compare-Death', 'Asthma-retain-Death', 'Wounds and Injuries-show-Brain Injuries', 'Wounds and Injuries-present-Brain Injuries', 'Wounds and Injuries-present-Death', 'Dementia-identify-Urinary Incontinence', 'Dementia-experience-Hallucinations', 'Headache Disorders, Secondary-experience-Hallucinations', 'Edema-yield-Inflammation', 'Synovitis-yield-Inflammation', 'Inflammation-play-Tooth Loss', 'Colorectal Neoplasms-reproduce-Death', 'Prostatic Hyperplasia-affected-Bone Neoplasms', 'Prostatic Hyperplasia-affected-Prostatic Neoplasms', 'Sarcopenia-play-Diabetes Mellitus', 'Bone Neoplasms-originate-Prostatic Neoplasms', 'Diabetes Mellitus-exacerbate-Sarcopenia', 'Dementia-compared-Pain', 'Dementia-assess-Hypertension', 'Dementia-assess-Cardiovascular Diseases', 'Dementia-assess-Diabetes Mellitus', 'Fractures, Bone-associated-Chronic Pain', 'Chronic Pain-associated-Fractures, Bone', 'HIV Infections-associated-Bone Neoplasms', 'Bone Neoplasms-associated-HIV Infections', 'Atherosclerosis-occure-Arteriosclerosis', 'Carcinoma, Squamous Cell-develop-Neoplasm Metastasis', 'Breast Neoplasms-detect-Neoplasm Metastasis', 'Infections-mediate-Malaria', 'Hyponatremia-increase-Fractures, Bone', 'Hyponatremia-contribute-Osteoporosis', 'Cerebral Small Vessel Diseases-manifest-Stroke, Lacunar', 'Cerebral Small Vessel Diseases-manifest-Atrophy', 'Diabetes Mellitus-manifest-Infections', 'Appendicitis-determine-Diabetes Mellitus', 'Coronary Artery Disease-occur-Diabetes Mellitus, Type 2', 'Diabetes Mellitus, Type 2-predict-Death', 'Diabetes Mellitus, Type 2-predict-Coronary Artery Disease', 'Death-predict-Coronary Artery Disease', 'Osteoarthritis-affect-Arthralgia', 'Death-guide-Liver Diseases', 'Hypertrophy-underpinned-Chronic Disease', 'Osteoarthritis-investigate-Pain', 'Arrhythmias, Cardiac-include-Anemia', 'Acute Kidney Injury-include-Anemia', 'Ventricular Dysfunction-include-Anemia', 'Osteoporosis-decrease-Sarcopenia', 'Cataract-lead-Vision Disorders', 'Kidney Diseases-include-Hematoma', 'Kidney Diseases-include-Airway Obstruction', 'Mitochondrial Diseases-isolated-Parkinson Disease', 'Death-predict-Hip Fractures', 'Alzheimer Disease-examine-Gliosis', 'Alzheimer Disease-exhibit-Neurodegenerative Diseases', 'Cerebral Small Vessel Diseases-linked-Ischemia', 'Cerebral Small Vessel Diseases-linked-Stroke', 'Inflammation-recognized-Sepsis', 'Critical Illness-exhibit-Inflammation', 'Sepsis-suffer-Critical Illness', 'Sepsis-experience-Death', 'Critical Illness-experience-Death', 'Ischemia-include-Death', 'Ischemia-include-Myocardial Infarction', 'Pneumococcal Infections-associated-Pneumonia', 'Pneumonia-associated-Pneumococcal Infections', 'Migraine Disorders-try-Arteriosclerosis', 'Diabetes Mellitus-undergo-Critical Illness', 'Osteoarthritis-undergo-Critical Illness', 'Wounds and Injuries-undergo-Critical Illness', 'Neoplasms-relapse-Cholestasis, Intrahepatic', 'Biliary Atresia-protected-Neoplasms', 'Metabolic Diseases-protected-Neoplasms', 'Reperfusion Injury-follow-Coronary Artery Disease', 'Liver Cirrhosis-associated-Neoplasms', 'Neoplasms-associated-Liver Cirrhosis', 'Peptic Ulcer-associated-Neoplasms', 'Neoplasms-associated-Peptic Ulcer', 'Diabetes Mellitus-reduce-Chemical and Drug Induced Liver Injury', 'Endocarditis-rise-Chronic Disease', 'Endocarditis-rise-Renal Insufficiency', 'Acute Kidney Injury-include-Sepsis', 'Acute Kidney Injury-include-Cardiac Complexes, Premature', 'Acute Kidney Injury-include-Delirium', 'Ventricular Remodeling-associated-Death', 'Death-associated-Ventricular Remodeling', 'Diabetes Mellitus, Type 2-caused-Insulin Resistance', 'Metabolic Diseases-caused-Insulin Resistance', 'Cataract-persist-Hallucinations', 'Heart Diseases-experience-Headache', 'Heart Diseases-experience-Tension-Type Headache', 'Spondylosis-lead-Spinal Cord Diseases', 'Spondylosis-impinge-Radiculopathy', 'Spondylosis-suggest-Spinal Cord Diseases', 'Heart Arrest-include-Progeria', 'Edema-differentiate-Basal Ganglia Diseases', 'Hypertension-lead-Brain Diseases', 'Microvascular Rarefaction-induced-Hypertension', 'Infections-develop-Heredodegenerative Disorders, Nervous System', 'Neurologic Manifestations-observed-Pneumonia, Aspiration', 'Parkinson Disease-exhibit-Neurodegenerative Diseases', 'Wounds and Injuries-underlie-Sarcopenia', 'Vision Disorders-underlie-Sarcopenia', 'Pain-contribute-Sleep Wake Disorders', 'Sarcoma, Kaposi-understand-Adrenal Insufficiency', 'Thrombosis-influence-Venous Thromboembolism', 'Cytomegalovirus Infections-elicit-Aneurysm', 'Multiple Myeloma-enable-Hypercalcemia', 'Multiple Myeloma-enable-Renal Insufficiency', 'Multiple Myeloma-enable-Anemia', 'Alzheimer Disease-manifested-Memory Disorders', 'Dementia-manifested-Memory Disorders', 'Alzheimer Disease-play-Diabetes Mellitus', 'Alzheimer Disease-play-Hyperlipidemias', 'Alzheimer Disease-play-Obesity', 'Diabetes Mellitus-examine-Hypoglycemia', 'Peritoneal Neoplasms-matched-Neoplasms', 'Parasitic Diseases-contribute-Death', 'Squamous Cell Carcinoma of Head and Neck-cause-Neoplasms', 'Squamous Cell Carcinoma of Head and Neck-cause-Papillomavirus Infections', 'Neoplasms-cause-Papillomavirus Infections', 'Alzheimer Disease-diagnosed-Death', 'Renal Insufficiency-compare-Fallopian Tube Diseases', 'Renal Insufficiency-undergo-Fallopian Tube Diseases', 'Constriction, Pathologic-undergo-Death', 'Hematoma-included-Death', 'Dyspnea-suffer-Heart Failure', 'Edema-suffer-Heart Failure', 'Adrenal Insufficiency-lead-Death', 'Muscular Atrophy-occur-Polyradiculopathy', 'Muscular Atrophy-occur-Spinal Cord Injuries', 'Heart Failure-suffer-Pain', 'Heart Failure-suffer-Respiratory Distress Syndrome', 'Polyradiculopathy-occur-Muscular Diseases', 'Heart Failure-suffer-Fatigue', 'Spinal Cord Injuries-occur-Muscular Diseases', 'Diabetes Mellitus-fall-Stroke', 'Diabetes Mellitus-fall-Heart Diseases', 'Stroke-fall-Heart Diseases', 'Hip Fractures-institutionalised-Fractures, Bone', 'Huntington Disease-linked-Mitochondrial Diseases', 'Huntington Disease-shown-Neurodegenerative Diseases', 'Huntington Disease-shown-Mitochondrial Diseases', 'Neurodegenerative Diseases-linked-Mitochondrial Diseases', 'Heart Diseases-contribute-Pulmonary Disease, Chronic Obstructive', 'Heart Diseases-contribute-Death', 'Crystal Arthropathies-cause-Osteoarthritis', 'Crystal Arthropathies-excluded-Infections', 'Fractures, Bone-compared-Rib Fractures', 'Gout-eliminate-Crystal Arthropathies', 'Pneumonia-contain-Infections', 'Death-include-Ventricular Dysfunction', 'Eczema-include-Pruritus', 'Psoriasis-include-Pruritus', 'Neoplasms-suggest-Mandibular Nerve Injuries', 'Neoplasms-suggest-Hemorrhage', 'Neoplasms-suggest-Osteonecrosis', 'Diabetes Mellitus-screened-Renal Insufficiency, Chronic', 'Sleep Initiation and Maintenance Disorders-defend-Calcinosis', 'Dementia-suffer-Critical Illness', 'Critical Illness-suffer-Death', 'Atrial Fibrillation-define-Rheumatic Heart Disease', 'Atrial Fibrillation-define-Thromboembolism', 'Atrial Fibrillation-define-Pulmonary Embolism', 'Atrial Fibrillation-related-Rheumatic Heart Disease', 'Atrial Fibrillation-related-Thromboembolism', 'Atrial Fibrillation-related-Pulmonary Embolism', 'Carotid Stenosis-cause-Cerebral Infarction', 'Bone Resorption-lead-Osteoporosis', 'Bone Neoplasms-induced-Diabetes Mellitus', 'Bone Neoplasms-found-Osteoporosis', 'Diabetes Mellitus-found-Osteoporosis', 'Death-related-Leukemia', 'Death-record-Alzheimer Disease', 'Death-result-Stroke', 'Death-result-Prostatic Neoplasms', 'Death-recorded-Alzheimer Disease', 'Sarcopenia-examine-Diabetes Mellitus', 'Atrial Fibrillation-remain-Hemorrhage', 'Death-illustrate-Arrhythmias, Cardiac', 'Death-remain-Delirium', 'Fractures, Bone-influence-Inflammation', 'Death-base-Delirium', 'Aneurysm-cover-Lymphatic Diseases', 'Aneurysm-manage-Pain', 'Pain-include-Chronic Pain', 'Pain-include-Aneurysm', 'Pain-associated-Aneurysm', 'Aneurysm-associated-Pain', 'Emphysema-limited-Airway Obstruction', 'Obesity-appear-Cardiac Output, Low', 'Obesity-fall-Cardiac Output, Low', 'Atherosclerosis-include-Renal Insufficiency, Chronic', 'Fibrosis-include-Renal Insufficiency, Chronic', 'Necrosis-result-Atrophy', 'Intervertebral Disc Degeneration-result-Atrophy', 'Neoplasms-observed-Carcinoma, Hepatocellular', 'Pruritus-alleviate-Neoplasm Metastasis', 'Rhinitis, Allergic-alleviate-Neoplasm Metastasis', 'Neoplasms-prescribed-Neoplasm Metastasis', 'Genetic Diseases, Inborn-display-Neoplasms', 'Werner Syndrome-arise-Neoplasms', 'Gout-lead-Inflammation', 'Gout-lead-Joint Diseases', 'Fractures, Bone-avoid-Death', 'Arrhythmias, Cardiac-associated-Frailty', 'Frailty-associated-Arrhythmias, Cardiac', 'Death-become-Acquired Immunodeficiency Syndrome', 'Hyperostosis-produce-Deglutition Disorders', 'Hyperostosis-produce-Paralysis', 'Deglutition Disorders-produce-Paralysis', 'Inflammation-cause-Liver Cirrhosis', 'Diabetes Mellitus-account-Blindness', 'Blindness-related-Diabetes Mellitus', 'Heart Diseases-remain-Death', 'Inflammation-identified-Sarcopenia', 'Inflammation-inflammage-Sarcopenia', 'Osteoporosis-identified-Inflammation', 'Fibrosis-inflammage-Sarcopenia', 'Cardiac Output, Low-associated-Hypotension, Orthostatic', 'Hypotension, Orthostatic-associated-Cardiac Output, Low', 'Osteoporosis-show-Mitochondrial Diseases', 'Kidney Diseases-found-Fatigue', 'Fatigue-associated-Hypotension, Orthostatic', 'Hypotension, Orthostatic-associated-Fatigue', 'Death-affected-Hip Fractures', 'Dementia-recognized-Cerebral Small Vessel Diseases', 'Postoperative Cognitive Complications-experience-Dementia', 'Postoperative Cognitive Complications-experience-Alzheimer Disease', 'Inflammation-associated-Postoperative Cognitive Complications', 'Postoperative Cognitive Complications-associated-Inflammation', 'Inflammation-use-Postoperative Cognitive Complications', 'Alzheimer Disease-discuss-Chronic Disease', 'Alzheimer Disease-recommend-Dementia', 'Chronic Disease-protect-Dementia', 'Immunologic Deficiency Syndromes-result-Hemorrhage', 'Osteoporosis-linked-Death', 'Death-succumb-Neoplasms', 'Death-succumb-Respiratory Tract Diseases', 'Hereditary Breast and Ovarian Cancer Syndrome-make-HIV Infections', 'Xeroderma Pigmentosum-prevent-Skin Neoplasms', 'Xeroderma Pigmentosum-result-Skin Neoplasms', 'Neoplasms-followed-Skin Neoplasms', 'Drug Hypersensitivity-result-Skin Neoplasms', 'Neoplasms-followed-Xeroderma Pigmentosum', 'Neoplasms-developed-Xeroderma Pigmentosum', 'Muscular Diseases-mimic-Ischemia', 'Skin Neoplasms-developed-Xeroderma Pigmentosum', 'Muscular Diseases-investigated-Myalgia', 'Carcinoma, Squamous Cell-followed-Skin Neoplasms', 'Melanoma-followed-Skin Neoplasms', 'Ischemia-investigated-Myalgia', 'Xeroderma Pigmentosum-followed-Carcinoma, Squamous Cell', 'Xeroderma Pigmentosum-developed-Carcinoma, Squamous Cell', 'Xeroderma Pigmentosum-followed-Melanoma', 'Xeroderma Pigmentosum-developed-Melanoma', 'Parkinson Disease-experience-Fractures, Bone', 'Delirium-lead-Postoperative Cognitive Complications', 'Death-occur-Sarcopenia', 'Diabetes Mellitus-affect-Pain', 'Diabetes Mellitus-identified-Metabolic Diseases', 'Pain-identified-Metabolic Diseases', 'Pain-affect-Musculoskeletal Diseases', 'Pain-affect-Tendon Injuries', 'Pain-affect-Tendinopathy', 'Metabolic Diseases-identified-Musculoskeletal Diseases', 'Metabolic Diseases-identified-Tendon Injuries', 'Appendicitis-related-Death', 'Metabolic Diseases-identified-Tendinopathy', 'Acute Disease-play-Infections', 'Cerebrovascular Disorders-include-HIV Infections', 'Stroke-followed-Atherosclerosis', 'Infections-classified-Zoonoses', 'Stroke-evaluate-Alzheimer Disease', 'Stroke-confer-Alzheimer Disease', 'Alzheimer Disease-increase-Stroke', 'Hypertension-mediated-Stroke', 'Alzheimer Disease-mediated-Stroke', 'Muscular Diseases-lead-Death', 'Myalgia-lead-Death', 'Muscle Weakness-lead-Death', 'Respiratory Insufficiency-lead-Death', 'Prediabetic State-observed-Diabetes Mellitus', 'Parkinson Disease-benefit-Synucleinopathies', 'Solitary Fibrous Tumors-seen-Pleural Diseases', 'Neoplasms-seen-Pleural Diseases', 'Chronic Kidney Disease-Mineral and Bone Disorder-predict-Death', 'Diabetes Mellitus-treated-Hypoglycemia', 'Immunologic Deficiency Syndromes-lead-Obesity', 'Pulmonary Disease, Chronic Obstructive-cause-Osteoporosis', 'Brain Injuries, Traumatic-consider-Death', 'Neck Pain-presented-Neurologic Manifestations', 'Death-registered-Wounds and Injuries', 'Death-caused-Brain Injuries, Traumatic', 'Wounds and Injuries-caused-Brain Injuries, Traumatic', 'Wounds and Injuries-passed-Death', 'Skin Diseases-affect-Inflammation', 'Skin Diseases-differentiated-Neoplasms', 'Granulomatous Disease, Chronic-characterized-Inflammation', 'Granulomatous Disease, Chronic-characterized-Granuloma', 'Death-reduce-Respiratory Tract Diseases', 'Death-promoted-Tuberculosis', 'Respiratory Tract Diseases-promoted-Tuberculosis', 'Cardiovascular Diseases-associated-Kidney Diseases', 'Kidney Diseases-associated-Cardiovascular Diseases', 'Osteoarthritis-affect-Arthritis', 'Joint Diseases-manage-Pain', 'Atrial Fibrillation-experience-Acute Coronary Syndrome', 'Retinal Degeneration-precede-Mucopolysaccharidosis II', 'Retinal Degeneration-followed-Nerve Degeneration', 'Disease-precede-Mucopolysaccharidosis II', 'Mucopolysaccharidosis II-followed-Nerve Degeneration', 'Disease-followed-Nerve Degeneration', 'Muscle Weakness-diagnosed-Myasthenia Gravis', 'Pulmonary Disease, Chronic Obstructive-hypothesized-Pulmonary Fibrosis', 'Ataxia-observed-Hip Fractures', 'Sarcopenia-observed-Hip Fractures', 'Hyperthyroidism-caused-Thyroid Diseases', 'Memory Disorders-revert-Hypothalamic Neoplasms', 'Breast Neoplasms-report-Obesity', 'Hearing Loss, Central-involved-Tinnitus', 'Atrial Fibrillation-detected-Heart Diseases', 'Stroke-detected-Heart Diseases', 'Cerebral Infarction-detected-Heart Diseases', 'Nervous System Diseases-characterized-Hypotension', 'Heart Failure-represent-Cardiotoxicity', 'Wounds and Injuries-reduce-Atherosclerosis', 'Osteoporosis-constitute-Thalassemia', 'Inflammation-decrease-Atherosclerosis', 'Pain-controlled-Adrenal Insufficiency', 'Arthritis-include-Pain', 'Hypertension-include-Pain', 'Pain-include-Asthma', 'Cardiovascular Diseases-include-Arthritis', 'Multiple Sclerosis-include-Pain', 'Breast Neoplasms-include-Pain', 'Cardiovascular Diseases-include-Headache', 'Arthritis-include-Asthma', 'Arthritis-include-Multiple Sclerosis', 'Cardiovascular Diseases-include-Osteoporosis', 'Arthritis-include-Breast Neoplasms', 'Hypertension-include-Arthritis', 'Hypertension-include-Headache', 'Hypertension-include-Low Back Pain', 'Hypertension-include-Asthma', 'Hypertension-include-Diabetes Mellitus, Type 2', 'Hypertension-include-Multiple Sclerosis', 'Hypertension-include-Breast Neoplasms', 'Hypertension-include-Osteoporosis', 'Pain-include-Diabetes Mellitus, Type 2', 'Pain-include-Breast Neoplasms', 'Pain-include-Osteoporosis', 'Arthritis-include-Diabetes Mellitus, Type 2', 'Arthritis-include-Osteoporosis', 'Headache-include-Asthma', 'Headache-include-Diabetes Mellitus, Type 2', 'Headache-include-Breast Neoplasms', 'Headache-include-Osteoporosis', 'Low Back Pain-include-Diabetes Mellitus, Type 2', 'Low Back Pain-include-Breast Neoplasms', 'Low Back Pain-include-Osteoporosis', 'Asthma-include-Breast Neoplasms', 'Asthma-include-Osteoporosis', 'Diabetes Mellitus, Type 2-include-Breast Neoplasms', 'Diabetes Mellitus, Type 2-include-Osteoporosis', 'Diabetes Mellitus, Type 2-include-Parkinson Disease', 'Breast Neoplasms-include-Osteoporosis', 'Inflammation-identified-Urinary Bladder, Neurogenic', 'Pneumonia-influence-Pulmonary Disease, Chronic Obstructive', 'Wounds and Injuries-include-Tooth Loss', 'Mouth Diseases-increase-Tooth Loss', 'Jaw, Edentulous-examined-Tooth Loss', 'Infections-develop-Mouth Diseases', 'Infections-develop-Central Nervous System Diseases', 'Infections-develop-Paralysis', 'Infections-develop-Death', 'Death-seen-Angina Pectoris', 'Angina Pectoris-reduce-Death', 'Obesity-drive-Diabetes Mellitus, Type 2', 'Anemia-malnourished-Malnutrition', 'Myotonic Dystrophy-considered-Alzheimer Disease', 'Myotonic Dystrophy-lead-Alzheimer Disease', 'Learning Disabilities-predict-Dementia', 'Hypotension-associated-Acute Kidney Injury', 'Acute Kidney Injury-associated-Hypotension', 'Psychomotor Disorders-provide-Brain Diseases', 'Hodgkin Disease-present-HIV Infections', 'Osteoporosis-characterised-Atrophy', 'Sarcopenia-considered-Osteoporotic Fractures', 'Cerebrovascular Disorders-measured-Diabetes Mellitus, Type 2', 'Diabetes Mellitus-aged-Cerebrovascular Disorders', 'Meibomian Gland Dysfunction-believed-Dry Eye Syndromes', 'Penile Neoplasms-use-Neoplasms', 'Acute Kidney Injury-evaluate-Shock', 'Diabetes Mellitus-raised-Coronary Artery Disease', 'Anophthalmos-limit-Cardiac Output, Low', 'Disease-characterized-Signs and Symptoms, Respiratory', 'Bone Diseases-referred-Neurodegenerative Diseases', 'Osteoarthritis-referred-Neurodegenerative Diseases', 'Sepsis-emerge-Communicable Diseases', 'Sepsis-emerge-Death', 'Opportunistic Infections-declining-Death', 'Colorectal Neoplasms-compare-Colonic Neoplasms', 'Colorectal Neoplasms-undergo-Rectal Neoplasms', 'Colonic Neoplasms-compare-Rectal Neoplasms', 'Atherosclerosis-defined-Constriction, Pathologic', 'Death-mediated-Carcinoma, Hepatocellular', 'Hypothermia-include-Wounds and Injuries', 'Hemorrhage-remain-Death', 'Neoplasms-inhibit-Carcinogenesis', 'Colitis, Ulcerative-complicated-Opportunistic Infections', 'Infections-complicate-Opportunistic Infections', 'HIV Infections-caused-Death', 'Infections-devoted-HIV Infections', 'Lung Diseases-show-Airway Obstruction', 'Lung Diseases-show-Inflammation', 'Lung Diseases-show-Infections', 'Cystic Fibrosis-show-Airway Obstruction', 'Cystic Fibrosis-show-Inflammation', 'Cystic Fibrosis-show-Infections', 'Neoplasms-inhibit-Drug-Related Side Effects and Adverse Reactions', 'Diabetes Mellitus-include-Ankle Injuries', 'Death-comprise-Coma', 'Lung Neoplasms-seen-Neoplasms', 'Neurodegenerative Diseases-characterize-Alzheimer Disease', 'Dementia-receive-Death', 'Nephritis-termed-Kidney Diseases', 'Drug-Related Side Effects and Adverse Reactions-termed-Kidney Diseases', 'Diabetes Mellitus-include-Retinal Diseases', 'Retinal Diseases-include-Vision Disorders', 'Retinal Diseases-result-Vision Disorders', 'Diabetes Mellitus-result-Vision Disorders', 'Diabetes Mellitus-develop-Tuberculosis', 'Diabetes Mellitus-associated-Tuberculosis', 'Tuberculosis-associated-Diabetes Mellitus', 'Colorectal Neoplasms, Hereditary Nonpolyposis-implicated-Prostatic Neoplasms', 'Spinal Cord Injuries-suffer-Uterine Cervicitis', 'Pain-investigated-Thyroid Diseases', 'Pain-investigated-Carpal Tunnel Syndrome', 'Atrophy-result-Neoplasms', 'Epilepsy-reported-Stroke', 'Seizures-reported-Stroke', 'Stroke-resemble-Epilepsy', 'Stroke-resemble-Seizures', 'Epilepsy-resemble-Seizures', 'Ischemia-induce-Infarction, Middle Cerebral Artery', 'Nerve Degeneration-study-Epilepsy', 'Diabetes Mellitus, Type 2-differ-Alzheimer Disease', 'Muscle Weakness-detect-Diabetes Mellitus', 'Renal Insufficiency-associated-HIV Infections', 'HIV Infections-associated-Renal Insufficiency', 'Renal Insufficiency-associated-Acquired Immunodeficiency Syndrome', 'Acquired Immunodeficiency Syndrome-associated-Renal Insufficiency', 'Alzheimer Disease-occur-Dementia', 'Heart Diseases-become-Death', 'Stroke-use-Ventricular Dysfunction, Left', 'Ventricular Dysfunction, Left-receive-Stroke', 'Infections-required-Drug-Related Side Effects and Adverse Reactions', 'Inflammation-associated-Emphysema', 'Emphysema-associated-Inflammation', 'Genetic Diseases, Inborn-caused-Immune Complex Diseases', 'Genetic Diseases, Inborn-caused-Neoplasms', 'Genetic Diseases, Inborn-caused-Diabetes Mellitus, Type 2', 'Genetic Diseases, Inborn-caused-Neurodegenerative Diseases', 'Ankle Fractures-decline-Fractures, Bone', 'Diabetes Mellitus, Type 2-type-Death', 'Atherosclerosis-type-Death', 'Inflammation-correlate-Prostatitis', 'Inflammation-implicate-Fibrosis', 'Inflammation-associated-Urinary Bladder Neck Obstruction', 'Urinary Bladder Neck Obstruction-associated-Inflammation', 'Prostatitis-contribute-Urinary Bladder Neck Obstruction', 'Fibrosis-contribute-Urinary Bladder Neck Obstruction', 'Inflammation-identify-Fibrosis', 'Immunologic Deficiency Syndromes-used-Neoplasms', 'Immunologic Deficiency Syndromes-establish-Neoplasms', 'Alzheimer Disease-rank-Death', 'Dementia-admitted-Hip Fractures', 'Brain Injuries, Traumatic-include-Fractures, Bone', 'Fractures, Bone-increase-Dementia', 'Brain Injuries, Traumatic-increase-Dementia', 'Lymphedema-associated-Neoplasms', 'Neoplasms-associated-Lymphedema', 'Lower Extremity Deformities, Congenital-manifest-Edema', 'Inflammation-known-Fibrosis', 'Smooth Muscle Tumor-known-Fibrosis', 'Stroke-collected-Death', 'Stroke-guided-Death', 'Leukopenia-develop-Infections', 'Metabolic Diseases-impact-Tooth, Impacted', 'Pneumonia-provide-Pneumococcal Infections', 'Neoplasms-related-Cerebral Infarction', 'Neoplasms-result-Cerebral Infarction', 'Blood Coagulation Disorders-result-Cerebral Infarction', 'Neoplasms-related-Stroke', 'Hematologic Neoplasms-occur-Bone Marrow Failure Disorders', 'Hematologic Neoplasms-occur-Hypotension', "Sjogren's Syndrome-diagnosed-Dry Eye Syndromes", "Sjogren's Syndrome-diagnosed-Xerostomia", 'Liver Failure-related-Inflammation', 'Liver Failure-related-Infections', 'Postpartum Hemorrhage-estimate-Dyspepsia', 'Postpartum Hemorrhage-estimate-Death', 'Dementia-present-Chronic Disease', 'Death-include-Nervous System Diseases', 'Head and Neck Neoplasms-increase-Adenomatous Polyposis Coli', 'Neoplasms-increase-Adenomatous Polyposis Coli', 'Infections-result-Inflammation', 'Hypertension-divided-Stroke', 'Hypertension-divided-Myocardial Infarction', 'Syncope-result-Facial Injuries', 'Syncope-compare-Craniocerebral Trauma', 'Fractures, Bone-comprise-Facial Injuries', 'Fractures, Bone-include-Craniofacial Abnormalities', 'Malnutrition-induce-Inflammation', 'Dementia-become-Death', 'Dementia-assessed-Ulcer', 'Glaucoma, Open-Angle-develop-Macular Degeneration', 'Myopia-develop-Macular Degeneration', 'Macular Degeneration-avoided-Glaucoma, Open-Angle', 'Neoplasms-found-Embolism', 'Ocular Hypotension-avoided-Glaucoma, Open-Angle', 'Neoplasms-found-Thrombosis', 'Neoplasms-reveal-Sarcoma, Endometrial Stromal', 'Death-attributed-Embolism', 'Rheumatic Diseases-associated-Neutropenia', 'Neutropenia-associated-Rheumatic Diseases', 'Rheumatic Diseases-give-Arthritis, Rheumatoid', 'Rheumatic Diseases-touch-Neutropenia', 'Arthritis, Rheumatoid-touch-Neutropenia', 'Alzheimer Disease-increase-Delirium', 'Carcinoma, Non-Small-Cell Lung-evaluate-Dyspnea', 'Candidemia-turn-Death', 'Death-occur-Atherosclerosis', 'Brain Injuries-promote-Stroke', 'Carcinoid Tumor-presented-End Stage Liver Disease', 'Nervous System Diseases-range-Dementia', 'Nervous System Diseases-range-Intracranial Hemorrhages', 'Migraine Disorders-examined-Stroke', 'Inflammation-attributed-Vasculitis', 'Migraine Disorders-use-Headache', 'Inflammation-cause-Nervous System Diseases', 'Vasculitis-cause-Nervous System Diseases', 'Stroke-observed-Migraine Disorders', 'Stroke-observed-Headache', 'Cushing Syndrome-induce-Kidney Diseases', 'Kidney Diseases-identify-Cushing Syndrome', 'Hypertension-identify-Kidney Diseases', 'Cushing Syndrome-show-Kidney Diseases', 'Cushing Syndrome-show-Hypertension', 'Infertility, Male-related-Heart Arrest', 'Infertility, Male-related-Infertility, Female', 'Infertility, Female-related-Heart Arrest', 'Infertility, Female-result-Heart Arrest', 'Parkinson Disease-matched-Cerebrovascular Disorders', 'Fibrosis-promote-Hypotension', 'Fibrosis-predispose-Heart Failure', 'Hypotension-predispose-Heart Failure', 'Infections-include-Osteomyelitis', 'Osteomyelitis-include-Infections', 'Diabetes Mellitus-affected-Muscular Diseases', 'Thromboembolism-identified-Heart Failure', 'Thromboembolism-identified-Hypertension', 'Thromboembolism-identified-Diabetes Mellitus', 'Thromboembolism-identified-Stroke', 'Thromboembolism-identified-Ischemia', 'Thromboembolism-identified-Aneurysm', 'Intracranial Aneurysm-defined-Aneurysm', 'Alzheimer Disease-highlight-Sleep Initiation and Maintenance Disorders', 'Atrial Fibrillation-observed-Death', 'Death-observed-Heart Diseases', 'Death-observed-Cardiomyopathies', 'Death-observed-Cerebrovascular Disorders', 'Death-observed-Pulmonary Disease, Chronic Obstructive', 'Atrial Fibrillation-result-Death', 'Osteoporosis-result-Bone Neoplasms', 'Cough-sampled-Cystic Fibrosis', 'Cough-sampled-Pseudomonas Infections', 'Osteoporotic Fractures-explain-Fractures, Bone', 'Neurologic Manifestations-identified-Mitochondrial Diseases', 'Neurodegenerative Diseases-include-Coronaviridae Infections', 'Heart Diseases-include-Coronaviridae Infections', 'Stroke-include-Coronaviridae Infections', 'HIV Infections-associated-Dystonia', 'Dystonia-associated-HIV Infections', 'Sleep Deprivation-reported-Sleep Wake Disorders', "Sjogren's Syndrome-include-Cardiomyopathies", "Sjogren's Syndrome-vary-Mastocytosis, Systemic", "Sjogren's Syndrome-vary-Lymphoma", 'Mastocytosis, Systemic-characterize-Lymphoma', 'Hip Fractures-lead-Osteoporosis', 'Inflammation-reduced-Fatigue', 'Weight Loss-reduced-Fatigue', 'Gastrointestinal Diseases-include-Colorectal Neoplasms', 'Gastrointestinal Diseases-include-Diverticular Diseases', 'Gastrointestinal Diseases-include-Constipation', 'Gastrointestinal Diseases-include-Anemia', 'Renal Insufficiency, Chronic-affect-Myocardial Infarction', 'Gaucher Disease-increase-Parkinson Disease', 'Lysosomal Storage Diseases-occur-Parkinson Disease', 'Hypertension-lowering-Death', 'Constriction, Pathologic-prevent-Cardiomyopathy, Dilated', 'Drug-Related Side Effects and Adverse Reactions-cause-Memory Disorders', 'Ovarian Diseases-evaluate-Ovarian Neoplasms', 'Venous Thrombosis-defined-Thrombosis', 'Venous Thrombosis-defined-Fractures, Bone', 'Sarcopenia-occur-Malnutrition', 'Sarcopenia-accelerated-Chronic Disease', 'Hyperglycemia-increase-Diabetes Mellitus', 'Inflammation-found-Pulmonary Disease, Chronic Obstructive', 'Inflammation-worsen-Cardiovascular Diseases', 'Inflammation-worsen-Diabetes Mellitus', 'Inflammation-worsen-Osteoporosis', 'Pulmonary Disease, Chronic Obstructive-worsen-Cardiovascular Diseases', 'Pulmonary Disease, Chronic Obstructive-worsen-Diabetes Mellitus', 'Pulmonary Disease, Chronic Obstructive-worsen-Osteoporosis', 'Sarcopenia-identify-Obesity', 'Sarcopenia-find-Fasciculation', 'Obesity-find-Fasciculation', 'Cardiovascular Diseases-remain-Stroke', 'Inflammation-play-Fractures, Bone', 'Death-compare-Femoral Fractures', 'Death-increased-Femoral Fractures', 'Inflammation-involved-Osteoarthritis', 'Cardiovascular Diseases-progress-Kidney Failure, Chronic', 'Optic Neuropathy, Ischemic-associated-Obesity', 'Obesity-associated-Optic Neuropathy, Ischemic', 'Death-examined-Dementia', 'Dementia-examine-Death', 'Obesity-bring-Diabetes Mellitus', 'Osteoporosis-characterized-Osteoarthritis', 'Osteogenesis Imperfecta-avoid-Inflammation', 'Neoplasms-include-Digestive System Neoplasms', 'Fractures, Bone-considered-Osteoporosis', 'Neoplasms-followed-Ear Diseases', 'Fragile X Syndrome-assess-Neurodegenerative Diseases', 'Bone Diseases, Metabolic-prevent-Tooth Loss', 'Osteoporosis-prevent-Tooth Loss', 'Memory Disorders-find-Pain', 'Pain-find-Dementia', 'Pain-see-Dementia', 'Neural Tube Defects-decrease-Head and Neck Neoplasms', 'Neoplasms-undergo-Heart Failure', 'Arthritis, Rheumatoid-associated-Obesity', 'Obesity-associated-Arthritis, Rheumatoid', 'Osteoporosis-suggested-Osteoporotic Fractures', 'Retinal Diseases-reported-Alzheimer Disease', 'Retinal Diseases-reported-Extranodal Extension', 'Pain-produce-Pigmentation Disorders', 'Retinal Diseases-reported-Neurodegenerative Diseases', 'Alzheimer Disease-reported-Extranodal Extension', 'Alzheimer Disease-reported-Neurodegenerative Diseases', 'Alzheimer Disease-find-Hypertension', 'Alzheimer Disease-find-Cataract', 'Pain-advance-Dementia', 'Pain-incorporate-Dementia', 'Stroke-show-Heart Failure', 'Stroke-show-Atrial Fibrillation', 'Aortic Aneurysm-use-Heart Arrest', 'Aortic Aneurysm-remain-Death', 'Death-consider-Urinary Bladder Neoplasms', 'Alzheimer Disease-contribute-Cerebrovascular Disorders', 'Dementia-projected-Alzheimer Disease', 'Hypotension, Orthostatic-defined-Hypertension', 'Hypothyroidism-associated-Renal Insufficiency, Chronic', 'Renal Insufficiency, Chronic-associated-Hypothyroidism', 'Osteoporosis-describe-Osteogenesis Imperfecta', 'Osteoporosis-describe-Adrenal Insufficiency', 'Osteoporosis-occur-Adrenal Insufficiency', 'Osteogenesis Imperfecta-occur-Adrenal Insufficiency', 'Renal Insufficiency, Chronic-adjusted-Hypertension', 'Renal Insufficiency, Chronic-adjusted-Diabetes Mellitus', 'Renal Insufficiency, Chronic-adjusted-Dyslipidemias', 'Renal Insufficiency, Chronic-adjusted-Hyperuricemia', 'Renal Insufficiency, Chronic-adjusted-Anemia', 'Renal Insufficiency, Chronic-adjusted-Obesity', 'Mycoses-lead-Subarachnoid Hemorrhage', 'Brain Injuries, Traumatic-result-Cardiac Output, Low', 'Genetic Diseases, Inborn-include-Kidney Diseases', 'Glucose Metabolism Disorders-trigger-Neurodegenerative Diseases', 'Glucose Metabolism Disorders-involved-Alzheimer Disease', 'Diabetes Mellitus-type-Dementia', 'Diabetes Mellitus-link-Dementia', 'Diabetes Mellitus-control-Aneurysm', 'Diabetes Mellitus-control-Heart Diseases', 'Diabetes Mellitus-control-Obesity', 'Cardiovascular Diseases-achieved-Weight Loss', 'Obesity-achieved-Weight Loss', 'Osteoporosis-exceed-Bone Resorption', 'Osteoporosis-exceed-Bone Neoplasms', 'Osteoporosis-exceed-Muscular Dystrophy, Duchenne', 'Bone Neoplasms-avert-Fractures, Bone', 'Peripheral Arterial Disease-complicated-Calcinosis', 'Atherosclerosis-underpin-Peripheral Arterial Disease', 'Vascular Calcification-underpin-Peripheral Arterial Disease', 'Calcinosis-underpin-Peripheral Arterial Disease', 'Atherosclerosis-associated-Arteriolosclerosis', 'Arteriolosclerosis-associated-Atherosclerosis', 'Hypertension-associated-Multiple Sclerosis', 'Multiple Sclerosis-associated-Hypertension', 'Hypoglycemia-set-Diabetes Mellitus', 'Hemorrhage-focused-Hemophilia A', 'Deglutition Disorders-associated-Stroke', 'Stroke-associated-Deglutition Disorders', 'Dementia-mention-Dehydration', 'Osteogenesis Imperfecta-represent-Osteoporosis', 'Hemolytic-Uremic Syndrome-lead-Death', 'Hemolytic-Uremic Syndrome-report-Death', 'Neoplasms-related-Obesity', 'Lymphoma-develop-Leukemia, Myeloid', 'Death-include-Asthma', 'Respiratory Insufficiency-include-Asthma', 'Dementia-overlap-Amyotrophic Lateral Sclerosis', 'Inflammatory Bowel Diseases-associated-Colorectal Neoplasms', 'Colorectal Neoplasms-associated-Inflammatory Bowel Diseases', 'Inflammatory Bowel Diseases-tied-Hodgkin Disease', 'Inflammatory Bowel Diseases-tied-Skin Neoplasms', 'Inflammatory Bowel Diseases-tied-Urologic Neoplasms', 'Parkinson Disease, Secondary-measure-Parkinson Disease', 'Mitochondrial Diseases-inform-Glaucoma', 'Mitochondrial Diseases-inform-Neurodegenerative Diseases', 'Optic Nerve Diseases-include-Mitochondrial Diseases', 'Mitochondrial Diseases-prevent-Vision Disorders', 'Optic Nerve Diseases-caused-Mitochondrial Diseases', 'Optic Nerve Diseases-provide-Glaucoma', 'Death-vary-Fractures, Bone', 'Drug-Related Side Effects and Adverse Reactions-manage-Renal Insufficiency, Chronic', 'Sleep Apnea Syndromes-cause-Renal Insufficiency, Chronic', 'Sleep Apnea Syndromes-undergo-Sleep Wake Disorders', 'Hypertension-undergo-Sleep Wake Disorders', 'Renal Insufficiency, Chronic-undergo-Sleep Wake Disorders', 'Hepatitis C, Chronic-seem-Choroideremia', 'Color Vision Defects-associated-Renal Tubular Transport, Inborn Errors', 'Renal Tubular Transport, Inborn Errors-associated-Color Vision Defects', 'Color Vision Defects-associated-Irritable Bowel Syndrome', 'Irritable Bowel Syndrome-associated-Color Vision Defects', 'Color Vision Defects-associated-Enuresis', 'Enuresis-associated-Color Vision Defects', 'Irritable Bowel Syndrome-include-Renal Tubular Transport, Inborn Errors', 'Enuresis-include-Renal Tubular Transport, Inborn Errors', 'Choroideremia-engage-Hepatitis C, Chronic', 'Memory Disorders-prevail-Dementia', 'Colorectal Neoplasms-display-Neoplasms', 'Hypothyroidism-show-Hyperthyroidism', 'Thrombocytopenia-show-Hemorrhage', 'Vision Disorders-associated-Headache Disorders, Secondary', 'Headache Disorders, Secondary-associated-Vision Disorders', 'Vision Disorders-maintain-Headache Disorders, Secondary', 'Carcinoma, Hepatocellular-represent-Liver Failure', 'Carcinoma, Hepatocellular-represent-Focal Nodular Hyperplasia', 'Liver Failure-represent-Cholangiocarcinoma', 'Liver Failure-represent-Focal Nodular Hyperplasia', 'Cholangiocarcinoma-represent-Focal Nodular Hyperplasia', 'Cholangiocarcinoma-represent-Liver Failure', 'Death-improve-Heart Failure', 'Hypoxia-screen-Hypoxia, Brain', 'Pain-divided-Low Back Pain', 'Pain-divided-Coronary Artery Disease', 'Pain-found-Obesity', 'Diverticulitis-develop-Obesity', 'Metabolic Diseases-associated-Hypogonadism', 'Hypogonadism-associated-Metabolic Diseases', 'Anemia, Sickle Cell-compensate-Anemia', 'Osteoporotic Fractures-include-Fractures, Bone', 'Spinal Fractures-include-Fractures, Bone', 'Alzheimer Disease-investigate-Death', 'Death-predict-Femoral Neck Fractures', 'Infections-suffer-Fractures, Bone', 'Infections-suffer-Hip Fractures', 'Acute Kidney Injury-increase-Renal Insufficiency, Chronic', 'Pain-tackle-Cardiovascular Diseases', 'Pain-tackle-Dementia', 'Death-emerge-Liver Diseases', 'Hemorrhage-include-Venous Thromboembolism', 'Neurodegenerative Diseases-include-Amyotrophic Lateral Sclerosis', 'Neurodegenerative Diseases-caused-Amyotrophic Lateral Sclerosis', 'Kidney Diseases-associated-Myocardial Infarction', 'Myocardial Infarction-associated-Kidney Diseases', 'Hypothyroidism-presented-Hyperthyroidism', 'Hypothyroidism-presented-Headache Disorders, Secondary', 'Hyperthyroidism-presented-Headache Disorders, Secondary', 'Sarcopenia-associated-Oculocerebrorenal Syndrome', 'Oculocerebrorenal Syndrome-associated-Sarcopenia', 'Sarcopenia-lack-Fractures, Bone', 'Erectile Dysfunction-increase-Death', 'Death-indicate-Dementia', 'Coronary Artery Disease-associated-Heart Valve Diseases', 'Heart Valve Diseases-associated-Coronary Artery Disease', 'Erectile Dysfunction-base-Hypogonadism', 'Stroke-associated-Neurogenic Inflammation', 'Neurogenic Inflammation-associated-Stroke', 'Stroke-associated-Postpartum Hemorrhage', 'Postpartum Hemorrhage-associated-Stroke', 'Cerebral Infarction-disaggregate-Blood Platelet Disorders', 'Cerebral Hemorrhage-disaggregate-Blood Platelet Disorders', 'Infarction, Middle Cerebral Artery-induce-Thrombosis', 'Coronary Artery Disease-reduce-Nerve Degeneration', 'Wounds and Injuries-admitted-Pulmonary Disease, Chronic Obstructive', 'Cerebral Infarction-induced-Thrombosis', 'Osteoarthritis-caused-Obesity', 'Osteoarthritis-caused-Wounds and Injuries', 'Neurodegenerative Diseases-caused-Obesity', 'Aneuploidy-play-Neurodegenerative Diseases', 'Aneuploidy-play-Alzheimer Disease', 'Aneuploidy-found-Alzheimer Disease', 'Spinal Cord Diseases-present-Spinal Stenosis', 'Atrophy-reduce-Multiple Sclerosis', 'Atrophy-reduce-Coinfection', 'Multiple Sclerosis-reduce-Coinfection', 'Memory Disorders-progress-Dementia', 'Communicable Diseases-diagnosed-Headache Disorders, Secondary', 'Death-elevated-Hypertension', 'Diabetes Mellitus-bring-Cardiovascular Diseases', 'Dementia-shared-Cardiovascular Diseases', 'Alzheimer Disease-shared-Cardiovascular Diseases', 'Hyperuricemia-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-Hyperuricemia', 'Hyperuricemia-associated-Osteoarthritis', 'Osteoarthritis-associated-Hyperuricemia', 'Hyperuricemia-associated-Jaw, Edentulous', 'Jaw, Edentulous-associated-Hyperuricemia', 'Hyperuricemia-associated-Osteoporosis', 'Osteoporosis-associated-Hyperuricemia', 'Hyperuricemia-result-Osteoporosis', 'Osteoarthritis-result-Osteoporosis', 'Jaw, Edentulous-result-Osteoporosis', 'Hyperuricemia-related-Osteoarthritis', 'Hyperuricemia-related-Pulmonary Disease, Chronic Obstructive', 'Sarcopenia-show-Muscular Diseases', 'Wounds and Injuries-released-Malnutrition', 'Cardiovascular Abnormalities-assess-Diabetes Mellitus', 'Hyperparathyroidism-counteract-Proteinuria', 'Cardiovascular Abnormalities-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-Cardiovascular Abnormalities', 'Diabetes Mellitus-compared-Cardiovascular Abnormalities', 'Headache Disorders, Secondary-develop-Low Back Pain', 'Headache Disorders, Secondary-develop-Pain', 'von Willebrand Diseases-identify-Angiodysplasia', 'Renal Insufficiency, Chronic-identify-Angiodysplasia', 'Aortic Valve Stenosis-identify-Angiodysplasia', 'Fractures, Bone-concluded-Death', 'Gastroenteritis-result-Death', 'Hepatitis B-shift-Carcinoma, Hepatocellular', 'Pain-diagnosed-Rupture', 'Sepsis-affect-Neoplasms', 'Sepsis-represent-Infections', 'Shock, Septic-represent-Infections', 'Sepsis-cause-Multiple Organ Failure', 'Sepsis-characterized-Critical Illness', 'Sepsis-cause-Immune System Diseases', 'Multiple Organ Failure-characterized-Critical Illness', 'Critical Illness-characterized-Immune System Diseases', 'Pain-occur-Fatigue', 'Immunologic Deficiency Syndromes-associated-Chronic Kidney Disease-Mineral and Bone Disorder', 'Chronic Kidney Disease-Mineral and Bone Disorder-associated-Immunologic Deficiency Syndromes', 'Sexual Dysfunction, Physiological-associated-Hypertension', 'Hypertension-associated-Sexual Dysfunction, Physiological', 'Sexual Dysfunction, Physiological-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-Sexual Dysfunction, Physiological', 'Fatigue-estimate-Dementia', 'Cataract-identify-Vision, Low', 'Cataract-identify-Blindness', 'Hearing Loss-facilitate-Dementia', 'Infections-lead-Carcinoma, Merkel Cell', 'Infections-lead-Skin Neoplasms', 'Carcinoma, Merkel Cell-promote-Arbovirus Infections', 'Atrial Fibrillation-develop-Cerebral Infarction', 'Neoplasms-include-Chromothripsis', 'Psoriasis-predict-Myocardial Infarction', 'Psoriasis-found-Cardiovascular Diseases', 'Periodontal Diseases-observed-Arthritis, Rheumatoid', 'Psoriasis-found-Stroke', 'Psoriasis-found-Diabetes Mellitus', 'Gingivitis-observed-Arthritis, Rheumatoid', 'Psoriasis-found-Hypertension', 'Psoriasis-found-Hyperlipidemias', 'Fractures, Bone-categorized-Fractures, Open', 'Periodontitis-observed-Arthritis, Rheumatoid', 'Psoriasis-found-Obesity', 'Fractures, Bone-categorized-Myoclonus', 'Psoriasis-found-Metabolic Syndrome', 'Obesity-sustain-Fractures, Bone', 'Histiocytic Disorders, Malignant-characterized-Arthritis', 'Acro-Osteolysis-coexist-Autoimmune Diseases', 'Acro-Osteolysis-coexist-Tuberculosis', 'Acro-Osteolysis-coexist-Neoplasms', 'Parkinson Disease-associated-Dystonia', 'Dystonia-associated-Parkinson Disease', 'Tremor-associated-Hypokinesia', 'Hypokinesia-associated-Tremor', 'Chronic Disease-overlooked-Vision Disorders', 'Vision Disorders-associated-Dyslipidemias', 'Dyslipidemias-associated-Vision Disorders', 'Vision Disorders-associated-Myocardial Infarction', 'Myocardial Infarction-associated-Vision Disorders', 'Vision Disorders-associated-Coronary Artery Disease', 'Coronary Artery Disease-associated-Vision Disorders', 'Vision Disorders-associated-Asthma', 'Asthma-associated-Vision Disorders', 'Heart Failure-divide-Atrial Fibrillation', 'Osteoporosis-measure-Fractures, Bone', 'Atrial Fibrillation-associated-Respiratory Distress Syndrome', 'Respiratory Distress Syndrome-associated-Atrial Fibrillation', 'Atrial Fibrillation-associated-Respiratory Insufficiency', 'Respiratory Insufficiency-associated-Atrial Fibrillation', 'Atrial Fibrillation-associated-Sepsis', 'Sepsis-associated-Atrial Fibrillation', 'Atrial Fibrillation-found-Heart Failure', 'Pneumonia-detected-Infections', 'Neoplasms-include-Inflammation', 'Lung Neoplasms-present-Mycoses', 'Hyponatremia-affect-Fractures, Bone', 'Hip Fractures-assessed-Hyponatremia', 'Hyponatremia-result-Hip Fractures', 'Renal Insufficiency-associated-Calcinosis', 'Calcinosis-associated-Renal Insufficiency', 'Proteinuria-live-HIV Infections', 'Renal Insufficiency, Chronic-shown-Kidney Diseases', 'Heart Failure-differ-Fatigue', 'Heart Failure-override-Dyspnea', 'Fatigue-override-Dyspnea', 'Chronic Pain-Jont-Pain', 'Carcinosarcoma-followed-Leiomyosarcoma', 'Aortic Arch Syndromes-associated-Kidney Failure, Chronic', 'Kidney Failure, Chronic-associated-Aortic Arch Syndromes', 'Cerebrovascular Disorders-associated-Aortic Arch Syndromes', 'Aortic Arch Syndromes-associated-Cerebrovascular Disorders', 'Non-alcoholic Fatty Liver Disease-trigger-Inflammation', 'Stroke, Lacunar-result-Vascular System Injuries', 'Stroke, Lacunar-associated-Gait Disorders, Neurologic', 'Gait Disorders, Neurologic-associated-Stroke, Lacunar', 'Leukoencephalopathies-result-Vascular System Injuries', 'Vascular System Injuries-associated-Gait Disorders, Neurologic', 'Gait Disorders, Neurologic-associated-Vascular System Injuries', 'Vascular System Injuries-result-Gait Disorders, Neurologic', 'Cerebrovascular Disorders-emanate-Hypertension', 'Inflammation-cause-Erectile Dysfunction', 'Atherosclerosis-result-Erectile Dysfunction', 'Hypertension-confirm-Proteinuria', 'Obesity-confirm-Proteinuria', 'Proteinuria-confirm-Hematuria', 'Hypertension-avert-Myocardial Infarction', 'Hypertension-avert-Stroke', 'Kidney Diseases-confirm-Proteinuria', 'Kidney Diseases-confirm-Hematuria', 'Kidney Diseases-identify-Renal Insufficiency, Chronic', 'Proteinuria-identify-Renal Insufficiency, Chronic', 'Hematuria-identify-Renal Insufficiency, Chronic', 'Glucose Intolerance-include-Cardiovascular Diseases', 'Neoplasms-base-Death', 'Skin Neoplasms-exclude-Ovarian Neoplasms', 'Skin Neoplasms-estimated-Neoplasms', 'Brain Injuries, Traumatic-demonstrate-Death', 'Renal Insufficiency-associated-Cerebral Small Vessel Diseases', 'Cerebral Small Vessel Diseases-associated-Renal Insufficiency', 'Diabetes Mellitus-associate-Dementia', 'Dementia-associate-Diabetes Mellitus', 'Diabetes Mellitus-predispose-Death', 'Cardiovascular Diseases-predispose-Death', 'Hypertension-evaluate-Death', 'Infections-linked-Chronic Disease', 'Infections-linked-Heart Failure', 'Dementia-share-Coronary Artery Disease', 'Dementia-share-Metabolic Syndrome', 'Dementia-share-Inflammation', 'Metabolic Syndrome-include-Coronary Artery Disease', 'Inflammation-include-Coronary Artery Disease', 'Leukemia, Myeloid, Acute-present-Bone Marrow Failure Disorders', 'Rheumatic Diseases-associated-Giant Cell Arteritis', 'Giant Cell Arteritis-associated-Rheumatic Diseases', 'Rheumatic Diseases-share-Giant Cell Arteritis', 'Rheumatic Fever-share-Giant Cell Arteritis', 'Giant Cell Arteritis-result-Blindness', 'Giant Cell Arteritis-diagnosed-Rheumatic Diseases', 'Diabetes Mellitus, Type 2-fuelled-Obesity', 'Retinal Neovascularization-driven-Hypoxia', 'Retinal Neovascularization-driven-Metabolic Diseases', 'Retinal Diseases-include-Blindness', 'Diabetes Mellitus-include-Blindness', 'Blindness-include-Hypoxia', 'Blindness-driven-Hypoxia', 'Blindness-include-Metabolic Diseases', 'Blindness-driven-Metabolic Diseases', 'Retinal Diseases-driven-Hypoxia', 'Retinal Diseases-driven-Metabolic Diseases', 'Diabetes Mellitus-driven-Hypoxia', 'Diabetes Mellitus-driven-Metabolic Diseases', 'Neoplasms-caused-Death', 'Burkitt Lymphoma-treated-Drug-Related Side Effects and Adverse Reactions', 'Intestinal Diseases-suggest-Nervous System Diseases', 'Osteoarthritis, Hip-experience-Fractures, Bone', 'Osteoarthritis-experience-Fractures, Bone', 'Glucose Metabolism Disorders-progress-Ulcer', 'Pregnancy, Prolonged-remain-Death', 'Pregnancy, Prolonged-associate-Death', 'Death-associate-Pregnancy, Prolonged', 'Pregnancy, Prolonged-associate-Cardiovascular Diseases', 'Cardiovascular Diseases-associate-Pregnancy, Prolonged', 'Pregnancy, Prolonged-remain-Stroke', 'Prostatic Hyperplasia-proliferate-Inflammation', 'Death-underestimate-Dementia', 'Dementia-interprete-Death', 'Cerebral Amyloid Angiopathy-associated-Craniocerebral Trauma', 'Craniocerebral Trauma-associated-Cerebral Amyloid Angiopathy', 'Cerebral Hemorrhage-associated-Craniocerebral Trauma', 'Craniocerebral Trauma-associated-Cerebral Hemorrhage', 'Cerebral Hemorrhage-occur-Wounds and Injuries', 'Craniocerebral Trauma-occur-Wounds and Injuries', 'Cerebral Small Vessel Diseases-characterized-Fibrosis', 'Arteriolosclerosis-characterized-Fibrosis', 'Stroke-characterized-Fibrosis', 'Dementia, Vascular-characterized-Fibrosis', 'Sarcopenia-tend-Parkinsonian Disorders', 'Sarcopenia-related-Sleep Disorders, Circadian Rhythm', 'Heart Failure-seek-Cerebrovascular Trauma', 'Death-admitted-Wounds and Injuries', 'Osteoporotic Fractures-restore-Fractures, Bone', 'Thrombosis-found-Stroke', 'Stroke-studied-Carcinoma, Skin Appendage', 'Stroke-directed-Carcinoma, Skin Appendage', 'Death-provide-Seizures', 'Death-suggested-Delirium', 'Death-experience-Delirium', 'Acute Kidney Injury-considered-Kidney Diseases', 'Communicable Diseases-reduce-Death', 'Ataxia-compare-Diabetes Mellitus', 'Cardiac Output, Low-compare-Diabetes Mellitus', 'Nervous System Diseases-live-Pain', 'Nervous System Diseases-live-Sleep Wake Disorders', 'Hemorrhage-result-Intracranial Thrombosis', 'Hemorrhage-result-Craniocerebral Trauma', 'Hemorrhage-result-Neoplasms', 'Hemorrhage-result-Infarction', 'Cerebral Hemorrhage-result-Intracranial Thrombosis', 'Cerebral Hemorrhage-result-Craniocerebral Trauma', 'Cerebral Hemorrhage-result-Neoplasms', 'Cerebral Hemorrhage-result-Infarction', 'Dementia-study-Cerebral Hemorrhage', 'Dementia-lead-Cerebral Hemorrhage', 'Fractures, Bone-encountered-Osteoporosis', 'Cockayne Syndrome-report-Peripheral Nervous System Diseases', 'Cockayne Syndrome-report-Jet Lag Syndrome', 'Sleep Wake Disorders-diagnosed-Sleep Initiation and Maintenance Disorders', 'Cardiac Output, Low-increase-Sleep Wake Disorders', 'Anemia, Aplastic-linked-Hemoglobinuria, Paroxysmal', 'Anemia, Aplastic-linked-Leukemia, Myeloid, Acute', 'Cardiomyopathy, Hypertrophic-suffer-Hypertension', 'Cardiomyopathy, Hypertrophic-diagnosed-Hypertrophy', 'Cardiomyopathy, Hypertrophic-diagnosed-Heart Septal Defects, Ventricular', 'Calcinosis-found-Cardiomyopathy, Hypertrophic', 'Hypertrophy-considered-Cardiomyopathy, Hypertrophic', 'Multiple Myeloma-prevent-Drug-Related Side Effects and Adverse Reactions', 'Rhinitis, Allergic-persist-Drug Hypersensitivity', 'Kidney Failure, Chronic-include-Hypertension', 'Arthritis, Rheumatoid-associated-Osteoporosis', 'Osteoporosis-associated-Arthritis, Rheumatoid', 'Metabolic Syndrome-examine-Hypercapnia', 'Cardiovascular Diseases-occur-Arthritis, Rheumatoid', 'Lung Diseases-occur-Arthritis, Rheumatoid', 'Neoplasms-occur-Arthritis, Rheumatoid', 'Muscular Atrophy-occur-Arthritis, Rheumatoid', 'Paralysis-tend-Vertigo', 'Asthma-exhibit-Cardiovascular Diseases', 'Peripheral Arterial Disease-affect-Ulcer', 'Osteoporotic Fractures-performed-Abnormalities, Drug-Induced', 'Death-exert-Neurodegenerative Diseases', 'Sarcopenia-exert-Neurodegenerative Diseases', 'Bone Diseases, Metabolic-exert-Neurodegenerative Diseases', 'Hypothermia-recommended-Heart Arrest', 'Hypothermia-recover-Heart Arrest', 'Pulmonary Disease, Chronic Obstructive-lead-Death', 'Obesity, Abdominal-assess-Heart Diseases', 'Synucleinopathies-involved-Ocular Motility Disorders', 'Multiple Organ Failure-reflect-Death', 'Diabetes Mellitus-account-Myocardial Infarction', 'Diabetes Mellitus-account-Stroke', 'Nervous System Diseases-span-Alzheimer Disease', 'Nervous System Diseases-span-Multiple Sclerosis', 'Alzheimer Disease-span-Multiple Sclerosis', 'Alzheimer Disease-promote-Memory Disorders', 'Adrenal Insufficiency-induced-Anophthalmos', 'Esotropia-induced-Anophthalmos', 'Metabolic Syndrome-thought-Cardiovascular Diseases', 'Metabolic Syndrome-thought-Diabetes Mellitus', 'Headache Disorders, Secondary-decrease-Halitosis', 'Hypertension-become-Ventricular Fibrillation', 'Hip Fractures-follow-Stroke', 'Hip Fractures-occur-Stroke', 'Stroke-involve-Hip Fractures', 'Neoplasms-alter-Death', 'Alzheimer Disease-alter-Death', 'Pain, Postoperative-control-Hip Fractures', 'Pain-control-Hip Fractures', 'Cataract-shown-Vision Disorders', 'Multiple Chronic Conditions-linked-Death', 'Multiple Chronic Conditions-examine-Thrombocytopenia', 'Multiple Chronic Conditions-linked-Neoplasms', 'Cardiovascular Diseases-increased-Metabolic Syndrome', 'Cardiovascular Diseases-increased-Obesity', 'Neoplasms-associated-Tachycardia, Atrioventricular Nodal Reentry', 'Tachycardia, Atrioventricular Nodal Reentry-associated-Neoplasms', 'Muscular Diseases-lead-Fractures, Bone', 'Delirium-include-Death', 'Azotemia-lead-Renal Insufficiency', 'Cardiovascular Diseases-treat-Stroke', 'Hypertension-treat-Stroke', 'Cerebral Small Vessel Diseases-predispose-Leukoencephalopathies', 'Neoplasms-retain-Ovarian Neoplasms', 'Kidney Diseases-avoided-Renal Insufficiency, Chronic', 'Kidney Diseases-prescribed-Renal Insufficiency, Chronic', 'Hyperthyroidism-become-Hypothyroidism', 'Inflammation-favored-Metabolic Diseases', 'Diabetes Mellitus-become-Deaf-Blind Disorders', 'Diabetes Mellitus-related-Heart Diseases', 'Heart Diseases-reveal-Diabetes Mellitus', 'Breast Neoplasms-increase-Neoplasm Invasiveness', 'Breast Neoplasms-increase-Neoplasms', 'Breast Neoplasms-exhibit-Neoplasms', 'Pneumococcal Infections-stimulate-Immunologic Deficiency Syndromes', 'Idiopathic Pulmonary Fibrosis-diagnose-Dyspnea', 'Idiopathic Pulmonary Fibrosis-attributed-Heart Failure', 'Idiopathic Pulmonary Fibrosis-attributed-Pulmonary Disease, Chronic Obstructive', 'Cough-attributed-Heart Failure', 'Cough-attributed-Pulmonary Disease, Chronic Obstructive', 'Dyspnea-attributed-Heart Failure', 'Dyspnea-attributed-Pulmonary Disease, Chronic Obstructive', 'Fatigue-attributed-Heart Failure', 'Fatigue-attributed-Pulmonary Disease, Chronic Obstructive', 'Lung Diseases-result-Respiratory Insufficiency', 'Lung Diseases-result-Death', 'Gallstones-experience-Cholecystitis', 'Diabetes Mellitus-associated-Gallstones', 'Gallstones-associated-Diabetes Mellitus', 'Pressure Ulcer-suffer-Skin Diseases', 'Thrombosis-use-Diabetes Mellitus', 'Delirium-referred-Dementia', 'Delirium-scored-Infections', 'Delirium-scored-Endocrine System Diseases', 'Delirium-underlie-Cardiovascular Diseases', 'Delirium-underlie-Central Nervous System Diseases', 'Diabetes Mellitus-use-Breast Neoplasms', 'Diabetes Mellitus-derived-Obesity', 'Facial Injuries-remove-Neoplasms', 'Hearing Loss-quantify-Dementia', 'Hearing Loss-postpone-Dementia', 'Infections-associated-Aneurysm', 'Aneurysm-associated-Infections', 'Stroke-prevent-Nerve Degeneration', 'Memory Disorders-recognized-Infections', 'Stroke-implicated-Dementia, Vascular', 'Dyslipidemias-associated-Dementia', 'Dementia-associated-Dyslipidemias', 'Heart Failure-assess-Death', 'Lung Diseases-assess-Death', 'Brain Infarction-influenced-Hypertension', 'Leukoencephalopathies-understand-Psychoses, Substance-Induced', 'Fatigue-decreased-Pain', 'Hypertrophy, Left Ventricular-show-Pericardial Effusion', 'Heart Diseases-mimic-Cardiomyopathy, Hypertrophic', 'Cardiomyopathies-observed-Cardiomyopathy, Hypertrophic', 'Heart Diseases-observed-Cardiomyopathy, Hypertrophic', 'Hydrocephalus-found-Urinary Incontinence', 'Speech Disorders-occur-Alzheimer Disease', 'Stroke-optimize-Atrial Fibrillation', 'Atrial Fibrillation-assess-Stroke', 'Fractures, Bone-try-Congenital, Hereditary, and Neonatal Diseases and Abnormalities', 'Heart Failure-develop-Dementia', 'Pyelonephritis-develop-Dementia', 'Inflammation-exhibit-Shock', 'Inflammation-exhibit-Colitis', 'Inflammation-exhibit-Myocardial Infarction', 'Inflammation-exhibit-Spinal Cord Injuries', 'Autoimmune Diseases-limit-Inflammation', 'Weight Loss-contribute-Muscle Weakness', 'Hypoalbuminemia-suggest-Inflammation', 'Hypoalbuminemia-suggest-Pulmonary Disease, Chronic Obstructive', 'Leukemia-related-Leukemia, Myeloid, Acute', 'Neuroblastoma-protect-Alzheimer Disease', 'Death-related-Cardiovascular Abnormalities', 'Death-related-Hypertrophy, Left Ventricular', 'Death-involve-Hypertrophy, Left Ventricular', 'Cardiovascular Abnormalities-involve-Hypertrophy, Left Ventricular', 'Cardiomyopathy, Hypertrophic-range-Death, Sudden', 'Hypertrophy, Left Ventricular-presented-Death', 'Osteoporotic Fractures-investigated-Fractures, Bone', 'Osteoporotic Fractures-determine-Fractures, Bone', 'Pain-hospitalized-Heart Failure', 'Fractures, Bone-differ-Arthritis, Rheumatoid', 'Long QT Syndrome-thought-Genetic Diseases, Inborn', 'Fractures, Bone-include-Arthritis, Rheumatoid', 'Eye Diseases-followed-Conjunctival Diseases', 'Eye Diseases-followed-Amblyopia', 'Atrophy-found-Alzheimer Disease', 'Neoplasms-lead-Cardiomegaly', 'Neoplasms-lead-Heart Failure', 'Osteoporosis-associate-Calcinosis', 'Calcinosis-associate-Osteoporosis', 'Obesity-accepted-Death', 'Death-reported-Cardiovascular Diseases', 'Death-reported-Hypertension', 'Death-reported-Stroke', 'Death-reported-Diabetes Mellitus', 'Chemical and Drug Induced Liver Injury-include-Abdominal Pain', 'Chemical and Drug Induced Liver Injury-include-Vomiting', 'Chemical and Drug Induced Liver Injury-include-Diarrhea', 'Chemical and Drug Induced Liver Injury-include-Dyspepsia', 'Chemical and Drug Induced Liver Injury-include-Exanthema', 'Chemical and Drug Induced Liver Injury-include-Arthralgia', 'Chemical and Drug Induced Liver Injury-include-Hyperuricemia', 'Ventricular Fibrillation-subjected-Ischemia', 'Cardiovascular Diseases-lead-Genetic Diseases, Inborn', 'Hypertension-lead-Multiple Organ Failure', 'Mitochondrial Diseases-associated-Lipodystrophy', 'Lipodystrophy-associated-Mitochondrial Diseases', 'Hypertension-underlie-Immune System Diseases', 'Mitochondrial Diseases-associated-Metabolic Syndrome', 'Metabolic Syndrome-associated-Mitochondrial Diseases', 'Aneurysm-promote-Inflammation', 'Leukoencephalopathies-observed-Infarction, Anterior Cerebral Artery', 'Diabetes Mellitus-accompanied-Alzheimer Disease', 'Obesity, Abdominal-associated-Dyslipidemias', 'Dyslipidemias-associated-Obesity, Abdominal', 'Hypertension-associated-Dyslipidemias', 'Dyslipidemias-associated-Hypertension', 'Diabetes Mellitus-associated-Dyslipidemias', 'Dyslipidemias-associated-Diabetes Mellitus', 'Parkinson Disease-estimate-Chronobiology Disorders', 'Fistula-accentuated-Inflammation', 'Fistula-accentuated-Diverticulitis', 'Inflammation-arise-Diverticulitis', 'Diverticulitis-presented-Hemorrhage', 'Intracranial Aneurysm-presented-Hemorrhage', 'Hypotension, Orthostatic-related-Death', 'Malnutrition-associated-Weight Loss', 'Weight Loss-associated-Malnutrition', 'Malnutrition-associated-Muscle Weakness', 'Muscle Weakness-associated-Malnutrition', 'Osteomyelitis-remain-Death', 'Osteomyelitis-show-Death', 'Atrial Fibrillation-posed-Arrhythmias, Cardiac', 'Atrial Fibrillation-vary-Arrhythmias, Cardiac', 'Atrial Fibrillation-vary-Heart Diseases', 'Atrial Fibrillation-vary-Metabolic Diseases', 'Atrial Fibrillation-vary-Diabetes Mellitus', 'Atrial Fibrillation-vary-Metabolic Syndrome', 'Atrial Fibrillation-vary-Hyperthyroidism', 'Arrhythmias, Cardiac-vary-Heart Diseases', 'Arrhythmias, Cardiac-vary-Metabolic Diseases', 'Arrhythmias, Cardiac-vary-Diabetes Mellitus', 'Arrhythmias, Cardiac-vary-Metabolic Syndrome', 'Arrhythmias, Cardiac-vary-Hyperthyroidism', 'Metabolic Syndrome-associated-Periodontal Diseases', 'Periodontal Diseases-associated-Metabolic Syndrome', 'Metabolic Syndrome-predict-Tooth Loss', 'Metabolic Syndrome-predict-Periodontal Diseases', 'Neoplasm Invasiveness-considered-Neoplasm Metastasis', 'Hypotension, Orthostatic-considered-Fractures, Bone', 'Hypotension, Orthostatic-considered-Cardiac Output, Low', 'Metabolic Syndrome-define-Diabetes Mellitus', 'Metabolic Syndrome-increase-Tooth Loss', 'Metabolic Syndrome-increase-Alveolar Bone Loss', 'Tooth Loss-estimated-Metabolic Syndrome', 'Periodontitis-estimated-Metabolic Syndrome', 'Craniocerebral Trauma-followed-Fractures, Bone', 'Muscular Diseases-differ-Neuromuscular Diseases', 'Musculoskeletal Diseases-followed-Pain', 'Alzheimer Disease-enrolled-Dementia', 'Neoplasms-known-Prostatic Neoplasms', 'Neoplasms-found-Neoplasm Metastasis', 'Neurologic Manifestations-suffer-Heredodegenerative Disorders, Nervous System', 'Parkinson Disease-carry-Sialic Acid Storage Disease', 'Wounds and Injuries-report-Death', 'Migraine Disorders-underlie-Sleep Initiation and Maintenance Disorders', 'Death-seen-Coma', 'Death-develop-Wounds and Injuries', 'Inflammation-lead-Vision Disorders', 'Aneuploidy-characterized-Cardiovascular Abnormalities', 'Polyploidy-characterized-Cardiovascular Abnormalities', 'Abortion, Septic-observed-Neoplasms', 'Abnormalities, Drug-Induced-observed-Neoplasms', 'Urinary Retention-lead-Urinary Bladder Diseases', 'Metabolic Syndrome-vary-Infections', 'Heart Failure-considered-Cardiovascular Diseases', 'Postpartum Hemorrhage-minimise-Hemorrhage', 'Atrial Fibrillation-increase-Renal Insufficiency, Chronic', 'Diabetes Mellitus-used-Death', 'Weight Loss-promote-Inflammation', 'Weight Loss-promote-Death', 'Hearing Loss-hear-Dementia', 'Dementia-hear-Death', 'Dementia-influence-Psychomotor Agitation', 'Diabetes Mellitus-associated-Hyperlipidemias', 'Hyperlipidemias-associated-Diabetes Mellitus', 'Neoplasms-assess-Parkinson Disease', 'Lung Neoplasms-associated-Parkinson Disease', 'Parkinson Disease-associated-Lung Neoplasms', 'Parkinson Disease-precede-Neoplasms', 'Parkinson Disease-associated-Neoplasms', 'Neoplasms-associated-Parkinson Disease', 'Nerve Degeneration-do-Headache Disorders, Secondary', 'Nerve Degeneration-do-Atrophy', 'Kidney Diseases-develop-Immunologic Deficiency Syndromes', 'Hemorrhage-do-Hemophilia A', 'Urinary Incontinence-associated-Adrenal Insufficiency', 'Adrenal Insufficiency-associated-Urinary Incontinence', 'Urinary Incontinence-associated-Immunologic Deficiency Syndromes', 'Immunologic Deficiency Syndromes-associated-Urinary Incontinence', 'Diabetes Mellitus-prevent-Fractures, Bone', 'Wounds and Injuries-play-Heart Arrest', 'Death-increased-Heart Failure', 'Ataxia-defined-Hearing Loss', 'Communicable Diseases-represent-Neoplasms', 'Fractures, Bone-include-Poisoning', 'Neoplasms-include-Poisoning', 'Neoplasms-cause-Infections', 'Sarcopenia-show-Osteoarthritis', 'Hypertension, Pulmonary-associated-Heart Diseases', 'Heart Diseases-associated-Hypertension, Pulmonary', 'Hypertension, Pulmonary-associated-Communicable Diseases', 'Communicable Diseases-associated-Hypertension, Pulmonary', 'Hypertension, Pulmonary-associated-Schistosomiasis', 'Schistosomiasis-associated-Hypertension, Pulmonary', 'Hypertension, Pulmonary-associated-Rheumatic Heart Disease', 'Rheumatic Heart Disease-associated-Hypertension, Pulmonary', 'Schistosomiasis-include-Communicable Diseases', 'Rheumatic Heart Disease-include-Communicable Diseases', 'Lung Diseases-become-Hypertension, Pulmonary', 'Respiratory Tract Infections-recognized-Immunologic Deficiency Syndromes', 'Coronary Artery Disease-calculate-Neoplasms', 'Coronary Artery Disease-compete-Neoplasms', 'Coronary Artery Disease-calculate-Pneumonia', 'Coronary Artery Disease-calculate-Pulmonary Disease, Chronic Obstructive', 'Coronary Artery Disease-calculate-Renal Insufficiency, Chronic', 'Coronary Artery Disease-calculate-Thrombosis', 'Coronary Artery Disease-calculate-Pulmonary Embolism', 'Coronary Artery Disease-calculate-Hip Fractures', 'Coronary Artery Disease-calculate-Dementia', 'Neoplasms-compete-Pneumonia', 'Neoplasms-compete-Pulmonary Disease, Chronic Obstructive', 'Neoplasms-compete-Renal Insufficiency, Chronic', 'Neoplasms-compete-Thrombosis', 'Neoplasms-compete-Pulmonary Embolism', 'Neoplasms-compete-Hip Fractures', 'Neoplasms-compete-Dementia', 'Weight Loss-associated-Hypoglycemia', 'Hypoglycemia-associated-Weight Loss', 'Death-cause-Anemia', 'Heart Valve Diseases-show-Sepsis', 'Intracranial Aneurysm-show-Sepsis', 'Deglutition Disorders-reported-Stroke', 'Deglutition Disorders-reported-Parkinson Disease', 'Deglutition Disorders-reported-Brain Injuries, Traumatic', 'Deglutition Disorders-reported-Pneumonia', 'Neoplasms-decrease-Lymphoma', 'Nocturia-underlie-Mastocytosis, Systemic', 'Aortic Diseases-result-Cerebrovascular Trauma', 'Osteoporotic Fractures-study-Amyloid Neuropathies', 'Oculocerebrorenal Syndrome-overrepresented-Infertility, Female', 'Periodontitis-associated-Dementia', 'Dementia-associated-Periodontitis', 'Periodontitis-associated-Alzheimer Disease', 'Alzheimer Disease-associated-Periodontitis', 'Periodontitis-mediated-Inflammation', 'Alzheimer Disease-mediated-Inflammation', 'Parkinson Disease-decrease-Ankle Injuries', 'Hyperplasia-include-Lung Diseases', 'Carcinoma, Basal Cell-appear-Ulcer', 'Sarcopenia-played-Inflammation', 'Drug-Related Side Effects and Adverse Reactions-treat-Lung Neoplasms', 'Delirium-accelerate-Dementia', 'Colorectal Neoplasms-present-Death', 'Pulmonary Disease, Chronic Obstructive-assess-Signs and Symptoms, Respiratory', 'Epilepsy-account-Headache', 'Epilepsy-account-Migraine Disorders', 'Epilepsy-account-Alzheimer Disease', 'Death-predominate-Epilepsy', 'Death-predominate-Epilepsy, Tonic-Clonic', 'Death-predominate-Seizures', 'Epilepsy-include-Death', 'Status Epilepticus-include-Death', 'Status Epilepticus-include-Epilepsy', 'Death-include-Seizures', 'Migraine Disorders-tend-Cardiovascular Diseases', 'Migraine Disorders-tend-Stroke', 'Migraine Disorders-tend-Dementia', 'Migraine Disorders-tend-Meningeal Neoplasms', 'Brain Neoplasms-tend-Cardiovascular Diseases', 'Brain Neoplasms-tend-Stroke', 'Brain Neoplasms-tend-Dementia', 'Brain Neoplasms-tend-Meningeal Neoplasms', 'Stroke-show-Chemical and Drug Induced Liver Injury', 'Stroke-show-Death', 'Hemorrhage-show-Chemical and Drug Induced Liver Injury', 'Hemorrhage-show-Death', 'Kidney Failure, Chronic-receive-Parkinson Disease', 'Pancreatic Neoplasms-ranked-Neoplasms', 'Thyroid Neoplasms-endocrine-Neoplasms', 'Thyroid Neoplasms-include-Neoplasms', 'Thyroid Neoplasms-include-Multiple Endocrine Neoplasia', 'Neoplasms-include-Ovarian Neoplasms', 'Neoplasms-include-Multiple Myeloma', 'Lymphatic Diseases-include-Neoplasms', 'Ovarian Neoplasms-include-Colorectal Neoplasms', 'Multiple Myeloma-include-Colorectal Neoplasms', 'Lymphatic Diseases-include-Colorectal Neoplasms', 'Neoplasms-calculated-Death', 'HIV Infections-associated-Carcinoma, Hepatocellular', 'Carcinoma, Hepatocellular-associated-HIV Infections', 'HIV Infections-associated-Lymphoma, Non-Hodgkin', 'Lymphoma, Non-Hodgkin-associated-HIV Infections', 'Diabetes Mellitus-lead-Glucose Metabolism Disorders', 'HIV Infections-highlight-Neoplasms', 'HIV Infections-associated-Sarcoma, Kaposi', 'Sarcoma, Kaposi-associated-HIV Infections', 'HIV Infections-associated-Hodgkin Disease', 'Hodgkin Disease-associated-HIV Infections', 'Neoplasms-influenced-Carcinogenesis', 'Obesity-develop-Tendinopathy', 'Vascular Calcification-correlated-Death', 'Atherosclerosis-correlated-Death', 'Genetic Diseases, Inborn-provide-Aneurysm', 'Vision Disorders-hear-Inflammation', 'Atrial Fibrillation-investigate-Peripheral Arterial Disease', 'Diabetes Mellitus-found-Restless Legs Syndrome', 'Hypertension-detected-Restless Legs Syndrome', 'Diabetes Mellitus-detected-Restless Legs Syndrome', 'Cardiac Output, Low-detected-Restless Legs Syndrome', 'Fractures, Bone-characterized-Wounds and Injuries', 'Muscle Spasticity-observed-Central Nervous System Diseases', 'Coronary Artery Disease-include-Neoplasms', 'Cardiomyopathies-include-Neoplasms', 'Heart Failure-include-Neoplasms', 'Death-caused-Dementia', 'Atherosclerosis-associated-Alzheimer Disease', 'Alzheimer Disease-associated-Atherosclerosis', 'Hip Fractures-derive-Death', 'Infections-caused-Death', 'Obesity-defined-Thinness', 'Diabetes Mellitus-considered-Death', 'Death-studied-Diabetic Nephropathies', 'Death-represent-Kidney Diseases', 'Death-include-Renal Insufficiency', 'Death-include-Mitral Valve Insufficiency', 'Death-include-Tricuspid Valve Insufficiency', 'Death-include-Aortic Valve Stenosis', 'Parkinson Disease-involve-Thymoma', 'Parkinson Disease-accompanied-Agammaglobulinemia', 'Immunologic Deficiency Syndromes-involve-Thymoma', 'Parkinson Disease-accompanied-Agranulocytosis', 'Immunologic Deficiency Syndromes-involve-Agammaglobulinemia', 'Immunologic Deficiency Syndromes-accompanied-Agammaglobulinemia', 'Thymoma-accompanied-Agammaglobulinemia', 'Shock, Septic-end-Death', 'Agammaglobulinemia-detected-Agranulocytosis', 'Myocardial Infarction-known-Hemorrhage', 'Hypertension-increase-Porencephaly', 'Hemorrhage-preferred-Acute Coronary Syndrome', 'Diabetes Mellitus-show-Inflammation', 'Myelodysplastic Syndromes-develop-Dementia', 'Aneurysm-measured-Kidney Diseases', 'Epilepsy-perform-Status Epilepticus', 'Epilepsy-show-Seizures', 'Fibrosis-reduce-Ureteral Obstruction', 'Fibrosis-reduce-Reperfusion Injury', 'Pneumonia-develop-Death', 'Weight Loss-live-Urinary Incontinence', 'Abnormalities, Drug-Induced-suffer-Sleep Apnea, Obstructive', 'Gout-filled-Pain', 'Epilepsy-increase-Stroke', 'Osteoporosis-investigated-HIV Infections', 'Lung Diseases-found-Scleroderma, Systemic', 'Hypertension, Pulmonary-found-Scleroderma, Systemic', 'Ventricular Remodeling-associated-Heart Failure', 'Heart Failure-associated-Ventricular Remodeling', 'Hypoxia-lead-Leigh Disease', 'Hypoxia-lead-Mitochondrial Diseases', 'Anorexia-associated-Anemia', 'Anemia-associated-Anorexia', 'Sarcopenia-result-Chronic Disease', 'Sarcopenia-occur-Osteoporosis', 'Sarcopenia-occur-Fractures, Bone', 'Wounds and Injuries-include-Hip Fractures', 'Cardiovascular Diseases-develop-Dementia', 'Cytomegalovirus Infections-associated-Infections', 'Infections-associated-Cytomegalovirus Infections', 'Lung Diseases-include-Heart Failure', 'Lung Diseases-include-Stroke', 'Lung Diseases-include-Pulmonary Disease, Chronic Obstructive', 'Basal Ganglia Diseases-occur-Parkinson Disease', 'Osteoarthritis-divided-Joint Diseases', 'Pneumococcal Infections-account-Diabetes Mellitus', 'Diabetes Mellitus-account-Pneumococcal Infections', 'Skin Diseases-act-Acne Vulgaris', 'Skin Diseases-attenuate-Neoplasms', 'Dementia-promote-Death', 'Alzheimer Disease-track-Nervous System Diseases', 'Supranuclear Palsy, Progressive-cause-Paralysis', 'Supranuclear Palsy, Progressive-cause-Parkinson Disease, Secondary', 'Supranuclear Palsy, Progressive-cause-Dementia', 'Sleepiness-treat-Apnea', 'Neurodegenerative Diseases-treat-Mitochondrial Diseases', 'Epilepsy-represent-Cerebrovascular Disorders', 'Epilepsy-represent-Dementia', 'Radiculopathy-include-Low Back Pain', 'Colonic Polyps-prevent-Colorectal Neoplasms', 'Fractures, Bone-treated-Osteoarthritis', 'Fractures, Bone-found-Neoplasms', 'Fractures, Bone-include-Hypotension', 'Infections-alleviate-Pulmonary Disease, Chronic Obstructive', 'Hepatitis B-include-Infections', 'Death-caused-Arbovirus Infections', 'Neoplasms-experience-Urinary Incontinence', 'Neoplasms-experience-Pruritus', 'Femoral Neck Fractures-put-Thromboembolism', 'Leukemia, Lymphocytic, Chronic, B-Cell-diagnosed-Lymphocytosis', 'Diabetes Mellitus-associated-Pulmonary Disease, Chronic Obstructive', 'Pulmonary Disease, Chronic Obstructive-associated-Diabetes Mellitus', 'Coronary Artery Disease-associated-Pulmonary Disease, Chronic Obstructive', 'Pulmonary Disease, Chronic Obstructive-associated-Coronary Artery Disease', 'Back Pain-stem-Intervertebral Disc Degeneration', 'Neurologic Manifestations-reflect-Sensation Disorders', 'Immunologic Deficiency Syndromes-lead-Dyskeratosis Congenita', 'Immunologic Deficiency Syndromes-lead-Anemia, Aplastic', 'Craniocerebral Trauma-include-Death', 'Mycoses-associated-Inflammation', 'Inflammation-associated-Mycoses', 'Infections-caused-Inflammation', 'Malaria-tend-Infections', 'Infections-followed-Autonomic Dysreflexia', 'Infections-followed-Neuralgia', 'Acute Kidney Injury-associated-Kidney Failure, Chronic', 'Kidney Failure, Chronic-associated-Acute Kidney Injury', 'Kidney Diseases-recognize-Acute Kidney Injury', 'Neoplasm Metastasis-increasing-Neoplasms', 'Renal Insufficiency, Chronic-appear-Kidney Failure, Chronic', 'Renal Insufficiency, Chronic-associated-Muscular Atrophy', 'Muscular Atrophy-associated-Renal Insufficiency, Chronic', 'Sarcopenia-used-Ataxia', 'Spinal Diseases-cause-Pain', 'Spinal Diseases-cause-Paralysis', 'Spinal Diseases-cause-Musculoskeletal Diseases', 'Heart Failure-predicted-Obesity, Abdominal', 'Heart Failure-predicted-Renal Insufficiency, Chronic', 'Obesity, Abdominal-predicted-Heart Failure', 'Renal Insufficiency, Chronic-predicted-Heart Failure', 'Cardiovascular Diseases-predicted-Obesity, Abdominal', 'Neck Injuries-trigger-Tinnitus', 'Atrophy-reverse-Stroke', 'Stroke-need-Neoplasms', 'Muscle Weakness-proposed-Sarcopenia', 'Migraine Disorders-occur-Headache', 'Headache Disorders-classified-Headache', 'Anuria-predict-Acute Kidney Injury', 'Neoplasms-determined-Inflammation', 'HIV Infections-promote-Colonic Neoplasms', 'Death-caused-Pelvic Neoplasms', 'Death-identified-Fractures, Bone', 'Pelvic Neoplasms-identified-Fractures, Bone', 'Leukemia-recapitulate-Fanconi Anemia', 'Stomatitis-include-Communicable Diseases', 'Hereditary Breast and Ovarian Cancer Syndrome-include-Communicable Diseases', "Sjogren's Syndrome-include-Communicable Diseases", 'Pelvic Neoplasms-related-Fractures, Bone', 'Nephrosclerosis-related-Hypertension', 'Xerostomia-associated-Urinary Bladder, Overactive', 'Urinary Bladder, Overactive-associated-Xerostomia', 'Angina Pectoris-compare-Death', 'Angina Pectoris-compare-Hemorrhage', 'Angina Pectoris-compare-Acute Coronary Syndrome', 'Sleep Wake Disorders-characterized-Hypoxia', 'Bone Neoplasms-maximize-Osteoporosis', 'Coronary Artery Disease-combined-Renal Insufficiency, Chronic', 'Abnormalities, Drug-Induced-include-Neurodegenerative Diseases', 'Abnormalities, Drug-Induced-include-Hematologic Neoplasms', 'Abnormalities, Drug-Induced-include-Anemia, Megaloblastic', 'Fallopian Tube Diseases-include-Anemia, Megaloblastic', 'Heart Defects, Congenital-include-Anemia, Megaloblastic', 'Neurodegenerative Diseases-include-Anemia, Megaloblastic', 'Anemia, Megaloblastic-include-Hematologic Neoplasms', 'Heart Failure-lead-Neoplasms', 'Carpal Tunnel Syndrome-followed-Headache Disorders, Secondary', 'Amyloidosis-examine-Carpal Tunnel Syndrome', 'Inflammation-drive-Hypoxia', 'Hypoxia-drive-Renal Insufficiency, Chronic', 'Renal Insufficiency, Chronic-driven-Hypoxia', 'Renal Insufficiency, Chronic-driven-Renal Insufficiency', 'Kidney Failure, Chronic-represent-Renal Insufficiency, Chronic', 'Signs and Symptoms, Respiratory-include-Lung Neoplasms', 'Sarcopenia-indicate-Death', 'Sarcopenia-indicate-Neoplasms', 'Death-indicate-Neoplasms', 'Seizures-spent-Status Epilepticus', 'Asthma-characterized-Cough', 'Chronic Disease-characterized-Cough', 'Death, Sudden, Cardiac-identified-Death', 'Death, Sudden, Cardiac-identified-Death, Sudden', 'Death-related-Death, Sudden, Cardiac', 'Renal Insufficiency, Chronic-exhibit-Acute Coronary Syndrome', 'Cardiovascular Diseases-exhibit-Acute Coronary Syndrome', 'Death-classified-Neoplasms', 'Neoplasms-followed-Stroke', 'Atrophy-lead-Xerostomia', 'Vascular Calcification-assess-Death', 'Sarcopenia-include-Carcinoma, Hepatocellular', 'Hemorrhage-related-Brain Injuries, Traumatic', 'Metabolic Syndrome-associated-Anophthalmos', 'Anophthalmos-associated-Metabolic Syndrome', 'Metabolic Syndrome-lead-Eye Diseases', 'Paraproteinemias-found-Neoplasms', 'Cellulitis-cause-Chronic Disease', 'Pain-cause-Chronic Disease', 'Neoplasms-initiate-Heart Arrest', 'Hypertension-appreciated-Leg Ulcer', 'Atrial Fibrillation-correlated-Fibrosis', 'Cough-associated-Drug Hypersensitivity', 'Drug Hypersensitivity-associated-Cough', 'Dyspnea, Paroxysmal-occur-Asthma', 'Asthma-occur-Pulmonary Disease, Chronic Obstructive', 'Dyspnea, Paroxysmal-characterized-Dyspnea', 'Dyspnea, Paroxysmal-occur-Pulmonary Disease, Chronic Obstructive', 'Dyspnea-occur-Pulmonary Disease, Chronic Obstructive', 'Osteoporotic Fractures-comprise-Sleep Initiation and Maintenance Disorders', 'Asthma-associated-Peripheral Arterial Disease', 'Peripheral Arterial Disease-associated-Asthma', 'Peripheral Arterial Disease-use-Asthma', 'Meibomian Gland Dysfunction-thought-Airway Obstruction', 'Meibomian Gland Dysfunction-observed-Atrophy', 'Dry Eye Syndromes-thought-Airway Obstruction', 'Death-increase-Sepsis', 'Hypothyroidism-define-Hyperthyroidism', 'Malaria-offer-Pain', 'Malaria-experience-Intermittent Claudication', 'Pain-experience-Intermittent Claudication', 'Leukemia-show-Death', 'Neoplasms-represent-Multiple Organ Failure', 'Death-calculated-Breast Neoplasms', 'Death-calculated-Lung Neoplasms', 'Death-calculated-Respiratory Tract Diseases', 'Weight Loss-diagnosed-Diabetes Mellitus', 'Neuromuscular Junction Diseases-contribute-Back Pain', 'Neuromuscular Junction Diseases-include-Kyphosis', 'Neuromuscular Junction Diseases-differ-Back Pain', 'Joint Diseases-include-Hemophilia A', 'Cardiovascular Diseases-include-Hemophilia A', 'Neoplasms-include-Hemophilia A', 'Renal Insufficiency-include-Hemophilia A', 'Liver Diseases-include-Hemophilia A', 'Neuromuscular Junction Diseases-evaluate-Back Pain', 'Hemophilia A-cope-Joint Diseases', 'Hypertension-predispose-Chronic Disease', 'Hemophilia A-cope-Fractures, Bone', 'Hemophilia A-cope-Hepatitis C', 'Obesity-predispose-Chronic Disease', 'Hepatitis C-impact-Neoplasms', 'Death-provide-Chronic Disease', 'Arrhythmias, Cardiac-predict-Myocardial Infarction', 'Ischemia-reported-Blindness', 'Leukoencephalopathies-shown-Alzheimer Disease', 'Pain-explore-Leg Ulcer', 'Ulcer-occur-Pain', 'Ulcer-occur-Sleep Wake Disorders', 'Pain-assessed-Sleep Wake Disorders', 'Pain-associated-Ulcer', 'Ulcer-associated-Pain', 'Ulcer-do-Sleep Wake Disorders', 'Ulcer-increase-Varicose Ulcer', 'Varicose Ulcer-increase-Sleep Wake Disorders', 'Arthritis-associated-Mitochondrial Diseases', 'Mitochondrial Diseases-associated-Arthritis', 'Asthma-associated-Pneumococcal Infections', 'Pneumococcal Infections-associated-Asthma', 'Pulmonary Disease, Chronic Obstructive-associated-Pneumococcal Infections', 'Pneumococcal Infections-associated-Pulmonary Disease, Chronic Obstructive', 'Cataract-contribute-Drug-Related Side Effects and Adverse Reactions', 'Cardio-Renal Syndrome-involve-Neurologic Manifestations', 'Cardio-Renal Syndrome-involve-Kidney Diseases', 'Osteochondritis-bring-Pain', 'Wounds and Injuries-associated-Arthritis, Rheumatoid', 'Arthritis, Rheumatoid-associated-Wounds and Injuries', 'Wounds and Injuries-associated-Obesity', 'Obesity-associated-Wounds and Injuries', 'Hypertension-lead-Dementia, Vascular', 'Hypertension-associated-Ischemia', 'Ischemia-associated-Hypertension', 'Cerebrovascular Disorders-lead-Dementia, Vascular', 'Keratitis, Dendritic-associated-Dementia', 'Dementia-associated-Keratitis, Dendritic', 'Smoke Inhalation Injury-eliminate-Death', 'Melanoma-increase-Death', 'Fallopian Tube Neoplasms-decrease-Death', 'Fibrosis-prevent-End Stage Liver Disease', 'Heart Failure-manage-Fibrosis', 'Neoplasms-delivered-Death', 'Death-delivered-Neoplasms', 'Death-endorsed-Pulmonary Disease, Chronic Obstructive', 'Hypoxia-include-Reperfusion Injury', 'Fibrosis-correlate-Renal Insufficiency, Chronic', 'Fibrosis-correlate-Kidney Failure, Chronic', 'Hypertension-relate-Cardiovascular Diseases', 'Peripheral Arterial Disease-cover-Death', 'Myocardial Infarction-complicated-Heart Arrest', 'Coronary Stenosis-require-Takotsubo Cardiomyopathy', 'Pancreatitis-followed-Exocrine Pancreatic Insufficiency', 'Alzheimer Disease-demonstrated-Atrophy', 'Atrophy-use-Alzheimer Disease', 'Epilepsy-include-Chronic Disease', 'Neoplasms-underlie-Genetic Diseases, Inborn', 'Genetic Diseases, Inborn-underlie-Coronaviridae Infections', 'Growth Disorders-underlie-Genetic Diseases, Inborn', 'Coronaviridae Infections-characterized-Growth Disorders', 'Brain Neoplasms-caused-Wounds and Injuries', 'Hip Fractures-occur-Fractures, Bone', 'Death-adjusted-Albuminuria', 'Alkalosis-associated-Death', 'Death-associated-Alkalosis', 'Hip Fractures-account-Death', 'Osteoporosis-generate-Fractures, Bone', 'Pneumococcal Infections-linked-Infections', 'Death-diminish-Colorectal Neoplasms', 'Hypertension-observed-Glaucoma', 'Hypertension-observed-Asthma', 'Chronic Disease-relate-Inflammation', 'Atrial Fibrillation-indicate-Heart Diseases', 'Atrial Fibrillation-indicate-Cardiomyopathies', 'Malaria-base-Fever', 'Heart Valve Diseases-identified-Death', 'Heart Valve Diseases-identified-Cardiovascular Abnormalities', 'Heart Valve Diseases-identified-Ventricular Dysfunction', 'Death-analyzed-Hemophilia A', 'Stroke-managed-Hypertension', 'Hypoglycemia-increase-Fractures, Bone', 'Hypoglycemia-increase-Seizures', 'Hypoglycemia-increase-Coma', 'Hypoglycemia-decrease-Death', 'Death, Sudden-become-Cardiomyopathy, Hypertrophic', 'Death, Sudden-contribute-Heart Diseases', 'Cardiomyopathy, Hypertrophic-contribute-Heart Diseases', 'Parkinson Disease-attenuate-Neurodegenerative Diseases', 'Cardiomyopathy, Hypertrophic-regarded-Death, Sudden', 'Death, Sudden-terminate-Ventricular Fibrillation', 'Ventricular Dysfunction-compare-Heart Failure', 'Seizures-develop-Carcinoma, Squamous Cell', 'Diabetes Mellitus-affected-Dementia', 'Femoral Neck Fractures-eliminate-Pain', 'Constriction, Pathologic-reduce-Infections', 'Constriction, Pathologic-reduce-Death', 'Hearing Loss-implicate-Mitochondrial Diseases', 'Dementia-lead-Infections', 'Vertebrobasilar Insufficiency-accompany-Infarction', 'Wounds and Injuries-related-Osteoporosis', 'Bone Marrow Failure Disorders-related-Osteoporosis', 'Renal Insufficiency-defined-Death', 'Myelodysplastic Syndromes-develop-Leukemia, Myeloid, Acute', 'Renal Insufficiency-driven-Death', 'Muscular Atrophy-suggest-Reperfusion Injury', 'Cysts-include-Pituitary Diseases', 'Hypercholesterolemia-associated-Prostatic Neoplasms', 'Prostatic Neoplasms-associated-Hypercholesterolemia', 'Hypercholesterolemia-associated-Prostatic Hyperplasia', 'Prostatic Hyperplasia-associated-Hypercholesterolemia', 'Obesity-worsen-Hypogonadism', 'Hypogonadism-exacerbate-Erectile Dysfunction', 'Glucose Metabolism Disorders-change-Diabetes Mellitus', 'Neoplasms-compare-Delirium', 'Delirium-complicate-Pain', 'Delirium-complicate-Neoplasms', 'Delirium-compared-Pain', 'Cancer Pain-manage-Neoplasms', 'Neoplasms-manage-Delirium', 'Neoplasms-manage-Headache Disorders, Secondary', 'Pain-manage-Neoplasms', 'Weight Gain-associated-Atrial Fibrillation', 'Atrial Fibrillation-associated-Weight Gain', 'Weight Gain-increase-Atrial Fibrillation', 'Weight Loss-associated-Atrial Fibrillation', 'Atrial Fibrillation-associated-Weight Loss', 'Weight Loss-increase-Atrial Fibrillation', 'Kidney Diseases-identified-Hypertension', 'Aortic Aneurysm-develop-Sepsis', 'Aortic Aneurysm-develop-Infections', 'Sepsis-develop-Infections', 'Cardiovascular Diseases-experience-Occupational Diseases', 'Nervous System Diseases-accompany-Deglutition Disorders', 'Nervous System Diseases-accompany-Muscular Dystrophy, Duchenne', 'Hypertriglyceridemia-include-Dyslipidemias', 'Cataract-correlate-Cardiac Output, Low', 'Aneuploidy-arise-Colorectal Neoplasms', 'Inflammation-integrate-Colorectal Neoplasms', 'Inflammation-implicated-Intracranial Arteriosclerosis', 'Atrial Fibrillation-design-Arrhythmias, Cardiac', 'Lymphoma, Primary Effusion-characterized-Thyroiditis, Autoimmune', 'Atrial Fibrillation-recognized-Arrhythmias, Cardiac', 'Fibrosis-predominate-Arteriosclerosis', 'Cardiomyopathies-predominate-Arteriosclerosis', 'Neoplasms-include-Leiomyoma', 'Leiomyoma-include-Colorectal Neoplasms', 'Renal Insufficiency, Chronic-linked-Cardiovascular Diseases', 'Stroke-confoun-Frailty', 'Arthritis, Rheumatoid-treated-Necrosis', 'Stroke-impaired-Dementia', 'Stroke-impaired-Fatigue', 'Erectile Dysfunction-emerge-Diabetes Mellitus', 'Erectile Dysfunction-emerge-Metabolic Syndrome', 'Cardiomyopathy, Dilated-afflict-Muscular Dystrophy, Duchenne', 'Cardiomyopathy, Dilated-afflict-Death', 'Muscular Dystrophy, Duchenne-dilate-Cardiomyopathy, Dilated', 'Death-dilate-Cardiomyopathy, Dilated', 'Muscular Dystrophy, Duchenne-afflict-Death', 'Cardiomyopathy, Dilated-precede-Muscular Dystrophy, Duchenne', 'Death-performed-Hypothyroidism', 'Death-performed-Hyperthyroidism', 'Cardiovascular Diseases-defined-Ischemia', 'Cardiovascular Diseases-defined-Peripheral Arterial Disease', 'Parkinson Disease-characterised-Inflammation', 'Aneurysm-contribute-Ischemia', 'Aneurysm-contribute-Alzheimer Disease', 'Cerebrovascular Disorders-increase-Cerebral Infarction', 'Alzheimer Disease-ameliorate-Ischemia', 'Alzheimer Disease-slow-Neurodegenerative Diseases', 'Cerebrovascular Disorders-ameliorate-Ischemia', 'Ischemia-slow-Neurodegenerative Diseases', 'Chronic Kidney Disease-Mineral and Bone Disorder-worsen-Death', 'Hypotension-avoid-Drug-Related Side Effects and Adverse Reactions', 'Drug-Related Side Effects and Adverse Reactions-avoid-Death', 'Vasospasm, Intracranial-lead-Atherosclerosis', 'Thrombosis-lead-Atherosclerosis', 'Sarcopenia-range-Liver Failure', 'Sarcopenia-directed-Muscular Diseases', 'Coronary Artery Disease-result-Heart Failure', 'Coronary Artery Disease-complicate-Kidney Diseases', 'Heart Failure-complicate-Kidney Diseases', 'Constipation-increase-Peritoneal Neoplasms', 'Vitamin K Deficiency-identified-Vascular Calcification', 'Atrial Fibrillation-remain-Death', 'Fibrosis-contribute-Atrial Fibrillation', 'Amyloidosis-induce-Multiple Organ Failure', 'Death-observe-Alzheimer Disease', 'Metabolic Syndrome-concern-Osteoarthritis', 'Glaucoma, Open-Angle-report-Hyperpigmentation', 'Infections-cause-Coronary Artery Disease', 'Neoplasms-involved-Autoimmune Diseases', 'HIV Infections-involved-Autoimmune Diseases', 'Cerebrovascular Disorders-associated-Delirium', 'Delirium-associated-Cerebrovascular Disorders', 'Breast Neoplasms-explored-Rothmund-Thomson Syndrome', 'Memory Disorders-reduce-Brain Injuries, Traumatic', 'Cerebral Small Vessel Diseases-cause-Dementia', 'Leukoencephalopathies-include-Cerebrovascular Disorders', 'Cerebral Small Vessel Diseases-include-Cerebrovascular Disorders', 'Dental Caries-relieve-Bacterial Infections', "Xerostomia-include-Sjogren's Syndrome", 'Endocarditis-identify-Neoplasms', 'Wounds and Injuries-remain-Death', 'Diabetes Mellitus-based-Tuberculosis, Pulmonary', 'Cardiovascular Diseases-expressed-Myocardial Infarction', 'Cardiovascular Diseases-expressed-Stroke', 'Cardiovascular Diseases-expressed-Angina Pectoris', 'Cardiovascular Diseases-expressed-Ischemic Attack, Transient', 'Cardiovascular Diseases-expressed-Intermittent Claudication', 'Hypertension-contribute-Obesity', 'Osteoporosis-offered-Sarcopenia', 'Sarcopenia-offered-Fractures, Bone', 'Constriction, Pathologic-preferred-Musculoskeletal Diseases', 'Diabetes Mellitus-defined-Urinary Incontinence', 'Vascular Calcification-evoke-Atherosclerosis', 'Infections-constitute-Death', 'Immunologic Deficiency Syndromes-sustain-Hip Fractures', 'Hypertension-increased-Dementia, Vascular', 'Dementia, Vascular-associated-Cerebral Small Vessel Diseases', 'Cerebral Small Vessel Diseases-associated-Dementia, Vascular', 'Anemia-develop-Kidney Failure, Chronic', 'Pain-include-Back Pain', 'Tuberculosis-increase-Death', 'Metabolic Diseases-lead-Fractures, Bone', 'Lung Injury-result-Hemorrhage', 'Peripheral Arterial Disease-associated-Dystonia', 'Dystonia-associated-Peripheral Arterial Disease', 'Heredodegenerative Disorders, Nervous System-assess-Sleep Wake Disorders', 'Cerebral Small Vessel Diseases-give-Stroke', 'Mitral Valve Insufficiency-lead-Death', 'Endocarditis-present-Heart Valve Diseases', 'Heart Failure-promote-Atrial Fibrillation', 'Bone Neoplasms-present-Obesity', 'Obesity-present-Osteoporosis', 'Osteoarthritis-result-Cartilage Diseases', 'Abortion, Threatened-increase-Amenorrhea', 'Infections-require-Facial Paralysis', 'Hematoma, Subdural, Chronic-caused-Wounds and Injuries', 'Hematoma, Subdural, Chronic-caused-Hypertension', 'Wounds and Injuries-caused-Hypertension', 'Cerebral Infarction-include-Aneurysm', 'Neurologic Manifestations-include-Neurodegenerative Diseases', 'Respiratory Tract Infections-cause-Bronchiolitis', 'Respiratory Tract Infections-cause-Death', 'Nerve Degeneration-seem-Alzheimer Disease', 'Alzheimer Disease-include-Mitochondrial Diseases', 'Nerve Degeneration-associated-Mitochondrial Diseases', 'Mitochondrial Diseases-associated-Nerve Degeneration', 'Nerve Degeneration-linked-Alzheimer Disease', 'Stroke-increase-Alzheimer Disease', 'Alzheimer Disease-characterized-Death', 'Hemophilia A-face-Joint Diseases', 'Hemophilia A-face-Fractures, Bone', 'Hemophilia A-face-Hepatitis C', 'Hemophilia A-face-Neoplasms', 'Hemophilia A-face-Liver Diseases', 'Joint Diseases-provoke-Fractures, Bone', 'Joint Diseases-affect-Neoplasms', 'Chronic Disease-affect-Blood Coagulation Disorders', 'Cardiovascular Diseases-affect-Blood Coagulation Disorders', 'Renal Insufficiency, Chronic-affect-Blood Coagulation Disorders', 'Lymphoma-reduce-Neoplasms', 'Carotid Artery Diseases-correspond-Chronic Disease', 'HIV Infections-affected-AIDS Arteritis, Central Nervous System', 'Chronic Disease-appear-Death', 'Communicable Diseases-contribute-Death', 'Sepsis-increase-Shock, Septic', 'Olfaction Disorders-affect-Death', 'Tuberculosis-diagnosed-Stomach Neoplasms', 'Stomach Neoplasms-use-Tuberculosis', 'Stomach Neoplasms-analyzed-Death', 'Diabetes Mellitus-identified-Tuberculosis', 'Diabetes Mellitus-identified-Stomach Neoplasms', 'Pulmonary Disease, Chronic Obstructive-identified-Tuberculosis', 'Pulmonary Disease, Chronic Obstructive-identified-Stomach Neoplasms', 'Tuberculosis-identified-Stomach Neoplasms', 'Stomach Neoplasms-screened-Tuberculosis', 'Hereditary Central Nervous System Demyelinating Diseases-include-Nerve Degeneration', 'Seizures-prevent-Sleep Wake Disorders', 'Leukemia, Myeloid, Acute-mutated-Myelodysplastic Syndromes', 'Neoplasm Metastasis-correlated-Neoplasms, Multiple Primary', 'Hypertension-differ-Neurotoxicity Syndromes', 'Pulmonary Disease, Chronic Obstructive-underlie-Signs and Symptoms, Respiratory', 'Pulmonary Disease, Chronic Obstructive-confirm-Airway Obstruction', 'Signs and Symptoms, Respiratory-identify-Airway Obstruction', 'Signs and Symptoms, Respiratory-impart-Emphysema', 'Airway Obstruction-impact-Emphysema', 'Pulmonary Disease, Chronic Obstructive-evaluate-Bronchitis', 'Pulmonary Disease, Chronic Obstructive-evaluate-Emphysema', 'Brain Diseases-constitute-Death', 'Dementia-associated-Alcoholism', 'Alcoholism-associated-Dementia', 'Rhinitis, Vasomotor-aid-Cold Injury', 'Deglutition Disorders-predict-Respiratory Tract Diseases', 'Rare Diseases-expire-Heart Failure', 'Rare Diseases-expire-Renal Insufficiency', 'Delirium-recognised-Hyperkinesis', 'Postoperative Cognitive Complications-associated-Death', 'Death-associated-Postoperative Cognitive Complications', 'Delirium-reduce-Postoperative Cognitive Complications', 'Autoimmune Diseases-associated-Hemorrhage', 'Hemorrhage-associated-Autoimmune Diseases', 'Neoplasms-weighed-Drug-Related Side Effects and Adverse Reactions', 'Neural Tube Defects-remembered-Neurologic Manifestations', 'Canavan Disease-cause-Dementia', 'Neoplasms-increase-Drug-Related Side Effects and Adverse Reactions', 'Obesity-include-Death', 'Obesity-identified-Infections', 'Liver Diseases-identified-Infections', 'Inflammation-initiate-Hearing Loss', 'Prostatitis-describe-Iatrogenic Disease', 'Infections-assess-Communicable Diseases', 'Neuralgia-lead-Syncope', 'Neuralgia-lead-Seizures', 'Retinitis-considered-Ischemia', 'Malnutrition-estimated-Weight Loss', 'Retinal Diseases-lead-Vision Disorders', 'Neoplasms-mimic-Periodontitis', 'Neoplasms-mentioned-Death', 'Death-list-Neoplasms', 'Neoplasms-outweigh-Death', 'Neoplasms-mentioned-Parasitic Diseases', 'Immunologic Deficiency Syndromes-originate-Hypogonadism', 'Klinefelter Syndrome-acquire-Neoplasms', 'Klinefelter Syndrome-acquire-Infections', 'Klinefelter Syndrome-acquire-Hemochromatosis', 'Deglutition Disorders-caused-Stroke', 'Deglutition Disorders-caused-Heredodegenerative Disorders, Nervous System', 'Stroke-prevent-Pneumonia, Aspiration', 'Heredodegenerative Disorders, Nervous System-prevent-Pneumonia, Aspiration', 'Head and Neck Neoplasms-prevent-Pneumonia, Aspiration', 'Stroke-distinguish-Renal Insufficiency', 'Immunologic Deficiency Syndromes-contribute-Stroke', 'Glycogen Storage Disease Type II-associated-Death', 'Death-associated-Glycogen Storage Disease Type II', 'Infections-modulate-Fibrosis', 'Seizures-reduce-Obesity', 'Thyroiditis, Autoimmune-worsen-Hypothyroidism', 'Stroke-occur-Death', 'Sepsis-detected-Stroke', 'Hypokalemia-detected-Stroke', 'Keratitis-detected-Stroke', 'Death-used-Fractures, Bone', 'Leukemia, Myeloid, Acute-associated-Leukemia', 'Leukemia-associated-Leukemia, Myeloid, Acute', 'Alopecia-described-Coronary Artery Disease', 'Peripheral Arterial Disease-identify-Atrial Fibrillation', 'Atrial Fibrillation-examined-Peripheral Arterial Disease', 'Death-related-Autoimmune Diseases', 'Cerebral Hemorrhage-include-Cerebral Small Vessel Diseases', 'Cerebral Amyloid Angiopathy-associated-Hypertension', 'Hypertension-associated-Cerebral Amyloid Angiopathy', 'Death-reduce-Neoplasms', 'Hypertension-reflect-Death', 'Kidney Diseases-attenuate-Diabetic Nephropathies', 'Retinoschisis-detected-Retinal Detachment', 'Vision Disorders-considered-Myopia', 'Acute Kidney Injury-underlie-Cardiovascular Diseases', 'Diabetes Mellitus-underlie-Cardiovascular Diseases', 'Acute Kidney Injury-study-Sepsis', 'Dementia-considered-Malnutrition', 'Inflammation-contribute-Hematoma, Subdural, Chronic', 'Alzheimer Disease-increase-Postoperative Cognitive Complications', 'Alzheimer Disease-classified-Postoperative Cognitive Complications', 'Cockayne Syndrome-associated-Nervous System Diseases', 'Nervous System Diseases-associated-Cockayne Syndrome', 'Aging, Premature-associated-Nervous System Diseases', 'Nervous System Diseases-associated-Aging, Premature', 'Cleidocranial Dysplasia-followed-Hypertension', 'Hypertension-followed-Bronchitis', 'Infections-review-Acute Kidney Injury', 'Kidney Diseases-review-Acute Kidney Injury', 'Dengue-review-Acute Kidney Injury', 'Brain Injuries-differ-Brain Injuries, Traumatic', 'Parkinson Disease-affect-HIV Infections', 'HIV Infections-emerge-Parkinson Disease', 'HIV Infections-increase-Parkinson Disease', 'Lymphoma, AIDS-Related-seen-Parkinson Disease', 'Myxedema-develop-Hypothyroidism', 'Lymphoma, AIDS-Related-increase-Neurodegenerative Diseases', 'Hypothyroidism-reveal-Pleural Effusion', 'Hypothyroidism-reveal-Ascites', 'Sarcopenia-shrink-Muscle Weakness', 'Obesity-live-Glucose Intolerance', 'Prostatitis-followed-Urinary Bladder, Overactive', 'Prostatitis-implicate-Urinary Bladder Diseases', 'Anemia-defined-Malnutrition', 'Malnutrition-increase-Anemia', 'Sarcopenia-used-Osteoarthritis', 'Death-show-Sarcopenia', 'Dementia-live-Pain', 'Alzheimer Disease-distinguish-Headache Disorders, Secondary', 'Vision Disorders-improve-Cataract', 'Alzheimer Disease-used-Drug-Related Side Effects and Adverse Reactions', 'Stroke-occur-Arterial Occlusive Diseases', 'Stroke-occur-Constriction, Pathologic', 'Stroke-occur-Calcinosis', 'Progeria-occur-Arterial Occlusive Diseases', 'Progeria-occur-Constriction, Pathologic', 'Progeria-occur-Calcinosis', 'Obesity-control-Adrenal Insufficiency', 'Obesity-control-Diabetes Mellitus', 'Adrenal Insufficiency-control-Diabetes Mellitus', 'Myalgia-Cramping-Hypesthesia', 'Myalgia-followed-Muscle Weakness', 'Death-reduce-Drug-Related Side Effects and Adverse Reactions', 'Muscle Weakness-followed-Hypesthesia', 'Diabetes Mellitus-linked-Erectile Dysfunction', 'Cardiovascular Diseases-linked-Erectile Dysfunction', 'Erectile Dysfunction-described-Obesity', 'Neurodegenerative Diseases-devastate-Alzheimer Disease', 'Respiratory Insufficiency-develop-Delirium', 'Pain-balance-Constipation', 'Leukemia, Myeloid, Acute-show-Drug-Related Side Effects and Adverse Reactions', 'Neurologic Manifestations-generate-Brain Diseases, Metabolic', 'Alzheimer Disease-correspond-Neurodegenerative Diseases', 'Neurodegenerative Diseases-implicated-Inflammation', 'Cardiovascular Diseases-occur-Neoplasms', 'Cardiovascular Diseases-occur-Death', 'Aortic Aneurysm, Abdominal-occur-Neoplasms', 'Aortic Aneurysm, Abdominal-occur-Death', 'Death-distributed-Neoplasms', 'Renal Insufficiency, Chronic-estimated-Diabetes Mellitus, Type 2', 'Renal Insufficiency, Chronic-affect-Diabetes Mellitus, Type 2', 'Diabetes Mellitus, Type 2-develop-Kidney Diseases', 'Diabetes Mellitus-associated-Dehydration', 'Dehydration-associated-Diabetes Mellitus', 'Neurologic Manifestations-complement-Neurodegenerative Diseases', 'Urinary Bladder, Overactive-correlated-Erectile Dysfunction', 'Memory Disorders-describe-Dementia', 'Brain Diseases-describe-Dementia', 'Spinal Injuries-formed-Spinal Cord Injuries', 'Drug Overdose-investigate-Hypotension', 'Drug Overdose-associated-Hypotension', 'Hypotension-associated-Drug Overdose', 'Drug Overdose-investigate-Death', 'Tinnitus-associated-Hearing Loss, Central', 'Hearing Loss, Central-associated-Tinnitus', 'Breast Neoplasms-take-Erectile Dysfunction', 'Prostatic Neoplasms-take-Erectile Dysfunction', 'Thrombosis-referred-Ischemia', 'Mitral Valve Stenosis-compared-Atrial Fibrillation', 'Hypertension-compared-Mitral Valve Stenosis', 'Aortic Valve Stenosis-compared-Mitral Valve Stenosis', 'Atrial Fibrillation-compared-Mitral Valve Stenosis', 'Mitral Valve Stenosis-associated-Aortic Valve Stenosis', 'Aortic Valve Stenosis-associated-Mitral Valve Stenosis', 'Frailty-differentiated-Alzheimer Disease', 'Nervous System Diseases-result-Urinary Incontinence', 'Nervous System Diseases-result-Fecal Incontinence', 'Pudendal Neuralgia-result-Fecal Incontinence', 'Osteoarthritis-involve-Pain', 'Neoplasms-explain-Breast Neoplasms', 'Breast Neoplasms-drive-Neoplasms', 'Arteriosclerosis-associated-Hypertension', 'Hypertension-associated-Arteriosclerosis', 'Wounds and Injuries-include-Craniocerebral Trauma', 'Wounds and Injuries-fall-Craniocerebral Trauma', 'Wounds and Injuries-include-Blood Coagulation Disorders', 'Wounds and Injuries-complicated-Blood Coagulation Disorders', 'Craniocerebral Trauma-complicated-Blood Coagulation Disorders', 'Neoplasms-grow-Metabolic Diseases', 'Neoplasms-grow-Inflammation', 'Parkinson Disease-help-Hip Fractures', 'Delirium-help-Hip Fractures', 'Hyperthyroidism-induce-Atrial Fibrillation', 'Hyperthyroidism-induce-Arrhythmias, Cardiac', 'Hyperthyroidism-precipitate-Heart Failure', 'Hyperthyroidism-cause-Stroke', 'Atrial Fibrillation-precipitate-Heart Failure', 'Arrhythmias, Cardiac-precipitate-Heart Failure', 'Heart Failure-cause-Stroke', 'Angioedemas, Hereditary-characterized-Edema', 'Atherosclerosis-measure-Lupus Erythematosus, Systemic', 'Fractures, Bone-disrupt-Diabetes Mellitus', 'Seizures-buffer-Phenylketonurias', 'Parkinson Disease, Secondary-mimic-Parkinson Disease', 'Neoplasms-use-Kidney Neoplasms', 'Neoplasms-occur-Kidney Neoplasms', 'Neoplasms-use-Dementia', 'Neoplasms-occur-Dementia', 'Dementia-diagnosed-Neoplasms', 'Sleep Wake Disorders-associated-Thyroid Diseases', 'Thyroid Diseases-associated-Sleep Wake Disorders', 'Pulmonary Disease, Chronic Obstructive-suffer-Cardiovascular Diseases', 'Pulmonary Disease, Chronic Obstructive-suffer-Osteoporosis', 'Pulmonary Disease, Chronic Obstructive-suffer-Malnutrition', 'Pulmonary Disease, Chronic Obstructive-suffer-Metabolic Syndrome', 'Pulmonary Disease, Chronic Obstructive-suffer-Diabetes Mellitus', 'Pulmonary Disease, Chronic Obstructive-suffer-Lung Neoplasms', 'Stroke-associate-Death', 'Death-associate-Stroke', 'Immunologic Deficiency Syndromes-trigger-Inflammation', 'Immunologic Deficiency Syndromes-drive-Blister', 'Inflammation-drive-Blister', 'Ventricular Fibrillation-occur-Cardiomyopathy, Hypertrophic', 'Ventricular Fibrillation-occur-Death', 'Heart Arrest-occur-Cardiomyopathy, Hypertrophic', 'Heart Arrest-occur-Death', 'Heart Failure-occur-Cardiomyopathy, Hypertrophic', 'Heart Failure-occur-Death', 'Cardiomyopathy, Dilated-exhibit-Cardiomyopathy, Hypertrophic', 'Heart Failure-exhibit-Cardiomyopathy, Hypertrophic', 'Neurodegenerative Diseases-characterized-Alzheimer Disease', 'Hypercholesterolemia-used-Cardiovascular Diseases', 'Hypernatremia-minimize-Cardiovascular Diseases', 'Hypernatremia-minimize-Death', 'Echinococcosis, Pulmonary-show-Emphysema', 'Wounds and Injuries-hit-Brain Injuries, Traumatic', 'Wounds and Injuries-suffer-Brain Injuries, Traumatic', 'Brain Injuries, Traumatic-exhibit-Intracranial Hemorrhages', 'Intracranial Hemorrhages-associate-Wounds and Injuries', 'Wounds and Injuries-associate-Intracranial Hemorrhages', 'Brain Injuries, Traumatic-associate-Wounds and Injuries', 'Wounds and Injuries-associate-Brain Injuries, Traumatic', 'Seizures-compose-Epilepsies, Myoclonic', 'Epilepsies, Myoclonic-compose-Ventricular Premature Complexes', 'Seizures-compose-Ventricular Premature Complexes', 'Anemia-increase-Schistosomiasis japonica', 'Schistosomiasis japonica-attributed-Anemia', 'Infections-attributed-Anemia', 'Renal Insufficiency, Chronic-defined-Diabetes Mellitus, Type 2', 'Chronic Kidney Disease-Mineral and Bone Disorder-defined-Diabetes Mellitus, Type 2', 'Inflammation-improve-Seizures', 'Dementia-complicate-Pain', 'Dementia-express-Pain', 'Pain-compare-Wounds and Injuries', 'Death-use-Vision Disorders', 'Death-use-Hearing Loss', 'Anaphylaxis-categorized-Shock', 'Anaphylaxis-experience-Shock', 'Anaphylaxis-accompany-Shock', 'Drug Hypersensitivity-associated-Shock', 'Shock-associated-Drug Hypersensitivity', 'Anaphylaxis-accompanied-Shock', 'Vestibular Diseases-associated-Hearing Loss', 'Hearing Loss-associated-Vestibular Diseases', 'Alzheimer Disease-induce-Cerebrovascular Disorders', 'Ischemia-met-Dementia', 'Dementia-measured-Death', 'Arthralgia-targeted-Arthritis', 'Hypertension-associate-Cerebrovascular Disorders', 'Cerebrovascular Disorders-associate-Hypertension', 'Hypertension-account-Death', 'Diabetes Mellitus-known-Osteoarthritis', 'Inflammation-observed-Osteoarthritis', 'Glaucoma, Open-Angle-reflect-Optic Atrophy, Hereditary, Leber', 'Glaucoma, Open-Angle-place-Optic Nerve Diseases', 'Spinal Cord Injuries-occur-Blister', 'Osteoarthritis-exhibit-Sarcopenia', 'Drug-Related Side Effects and Adverse Reactions-aggregate-Amyotrophic Lateral Sclerosis', 'Pneumococcal Infections-defined-Respiratory Tract Infections', 'Pneumococcal Infections-hospitalized-Respiratory Tract Infections', 'Chronic Disease-affect-Neoplasms', 'Myotonic Dystrophy-affected-Carcinoma, Hepatocellular', 'Neoplasms-affected-Carcinoma, Hepatocellular', 'Fibromyalgia-characterized-Pain', 'Dementia-show-Infections', 'Dementia-show-Respiratory Insufficiency', 'Cerebral Infarction-occur-Atrial Fibrillation', 'Embolism-outnumber-Cerebral Hemorrhage', 'Stroke-occur-Atrial Fibrillation', 'Leukoencephalopathies-associated-Cerebral Infarction', 'Cerebral Infarction-associated-Leukoencephalopathies', 'Osteoporosis-associated-Muscular Dystrophy, Duchenne', 'Muscular Dystrophy, Duchenne-associated-Osteoporosis', 'POEMS Syndrome-seen-Gaucher Disease', 'Neoplasms-seen-Gaucher Disease', 'Wounds and Injuries-elicit-Cardiovascular Abnormalities', 'Leukoencephalopathies-contribute-Parkinson Disease', 'Leukoencephalopathies-worsen-Alzheimer Disease', 'Parkinson Disease-worsen-Alzheimer Disease', 'Leukoencephalopathies-associated-Cerebrovascular Disorders', 'Cerebrovascular Disorders-associated-Leukoencephalopathies', 'Leukoencephalopathies-associated-Parkinson Disease', 'Parkinson Disease-associated-Leukoencephalopathies', 'Leukoencephalopathies-influence-Parkinson Disease', 'Dermatitis, Atopic-linked-Drug Hypersensitivity', 'Leukoencephalopathies-cause-Parkinson Disease', 'Rhinitis-make-Asthma', 'Acute Coronary Syndrome-include-Communicable Diseases', 'Myocardial Infarction-include-Communicable Diseases', 'Ischemia-include-Communicable Diseases', 'Cardiomyopathies-include-Communicable Diseases', 'Atrial Fibrillation-include-Communicable Diseases', 'Renal Insufficiency, Chronic-include-Communicable Diseases', 'Protein-Energy Malnutrition-predict-Communicable Diseases', 'Weight Loss-predict-Communicable Diseases', 'Diabetes Mellitus-achieve-Weight Loss', 'Alcoholism-associated-Liver Diseases', 'Liver Diseases-associated-Alcoholism', 'Alcoholism-associated-Myocardial Infarction', 'Myocardial Infarction-associated-Alcoholism', 'Aneurysm-shared-Stroke', 'Aneurysm-shared-Dementia', 'Sarcopenia-exacerbate-Diabetes Mellitus', 'Diabetes Mellitus-exacerbate-Obesity', 'Sleep Wake Disorders-result-Psychomotor Disorders', 'Sleep Wake Disorders-misinterpreted-Dementia', 'Psychomotor Disorders-misinterpreted-Dementia', 'Sleep Wake Disorders-exacerbate-Dementia', 'Sleep Wake Disorders-impact-Dementia', 'Sleep Wake Disorders-include-Sleep Initiation and Maintenance Disorders', 'Sleep Wake Disorders-include-Disorders of Excessive Somnolence', 'Sleep Wake Disorders-include-Parasomnias', 'Dementia-include-Disorders of Excessive Somnolence', 'Dementia-impact-Sleep Wake Disorders', 'Dementia-include-Parasomnias', 'Dementia-impact-REM Sleep Behavior Disorder', 'Obesity-live-Neoplasms', 'Sleep Wake Disorders-exhibit-Vertigo', 'Tinnitus-mediate-Hearing Loss', 'Tinnitus-caused-Hearing Loss', 'Progeria-use-Intellectual Disability', 'Infections-resemble-Progeria', 'Progeria-investigate-Infections', 'Progeria-use-Infections', 'Nervous System Diseases-exclude-Dementia', 'Dementia-exclude-Diabetes Mellitus', 'Dementia-exclude-Respiratory Tract Diseases', 'Dementia-exclude-Liver Diseases', 'Dementia-exclude-Tinnitus', 'Dementia-exclude-Pain', 'Heart Failure-occur-Chronic Disease', 'Retinal Degeneration-include-Neurodegenerative Diseases', 'Mitochondrial Diseases-represent-Alzheimer Disease', 'Mitochondrial Diseases-represent-Neurodegenerative Diseases', 'Carcinogenesis-aimed-Neoplasms', 'Fragile X Syndrome-termed-Purpura', 'Atherosclerosis-considered-Cerebral Infarction', 'Arbovirus Infections-induced-Fever', 'Wounds and Injuries-summarise-Fractures, Bone', 'Glaucoma-lead-Nerve Degeneration', 'Ischemia-diagnose-Diabetic Foot', 'Ischemia-diagnose-Gangrene', 'Fatigue-reduce-Neoplasms', 'Death-increase-Obesity', 'Inflammation-associated-End Stage Liver Disease', 'End Stage Liver Disease-associated-Inflammation', 'Liver Cirrhosis-associated-End Stage Liver Disease', 'End Stage Liver Disease-associated-Liver Cirrhosis', 'Muscular Diseases-include-Hypertrophy', 'Hypertension-associated-Intracranial Aneurysm', 'Intracranial Aneurysm-associated-Hypertension', 'Coronary Artery Disease-associated-Intracranial Aneurysm', 'Intracranial Aneurysm-associated-Coronary Artery Disease', 'Hypertension-associated-Infarction, Anterior Cerebral Artery', 'Infarction, Anterior Cerebral Artery-associated-Hypertension', 'Hypertension-associated-Infarction, Middle Cerebral Artery', 'Infarction, Middle Cerebral Artery-associated-Hypertension', 'Intracranial Aneurysm-associated-Infarction, Anterior Cerebral Artery', 'Infarction, Anterior Cerebral Artery-associated-Intracranial Aneurysm', 'Intracranial Aneurysm-associated-Infarction, Middle Cerebral Artery', 'Infarction, Middle Cerebral Artery-associated-Intracranial Aneurysm', 'Coronary Artery Disease-associated-Aneurysm', 'Aneurysm-associated-Coronary Artery Disease', 'Mitochondrial Diseases-exacerbate-Acute Kidney Injury', 'Delayed Emergence from Anesthesia-exacerbate-Muscle Weakness', 'Delayed Emergence from Anesthesia-exacerbate-Respiratory Insufficiency', 'Renal Insufficiency, Chronic-increase-Inflammation', 'Infections-include-Fractures, Bone', 'Muscular Atrophy, Spinal-include-Neurodegenerative Diseases', 'HIV Infections-associated-Leukoencephalopathies', 'Leukoencephalopathies-associated-HIV Infections', 'Leukoencephalopathies-associated-Hepatitis C', 'Hepatitis C-associated-Leukoencephalopathies', 'Leukoencephalopathies-associated-Acquired Immunodeficiency Syndrome', 'Acquired Immunodeficiency Syndrome-associated-Leukoencephalopathies', 'Erectile Dysfunction-considered-Atherosclerosis', 'Neoplasms-relieve-Pain', 'Neoplasms-include-Adrenal Insufficiency', 'Neoplasms-facilitated-Adrenal Insufficiency', 'Neoplasms-suffer-Pain', 'Pneumonia, Aspiration-associated-Dehydration', 'Dehydration-associated-Pneumonia, Aspiration', 'Pneumonia, Aspiration-associated-Dementia', 'Dementia-associated-Pneumonia, Aspiration', 'Genetic Diseases, Inborn-diagnosed-Alzheimer Disease', 'Death-estimate-Dementia', 'HIV Infections-persist-Death', 'Hepatolenticular Degeneration-address-Cataract', 'Myopia-address-Cataract', 'Pain-accept-Osteoarthritis', 'Osteoarthritis-viewed-Chronic Disease', 'Myelodysplastic Syndromes-treat-Anemia', 'Bone Diseases, Metabolic-used-Fractures, Bone', 'Bone Diseases, Metabolic-compare-Fractures, Bone', 'Cutis Laxa-caused-Metabolic Diseases', 'Cardiovascular Diseases-related-Diabetes Mellitus', 'Inflammation-induced-Diabetes Mellitus', 'Diabetes Mellitus-display-Hemostatic Disorders', 'Diabetes Mellitus-display-Cardiovascular Diseases', 'Diabetes Mellitus-create-Inflammation', 'Cardiovascular Diseases-promoted-Diabetes Mellitus', 'Diabetes Mellitus-display-Aneurysm', 'Cardiovascular Diseases-promoted-Hemostatic Disorders', 'Hemostatic Disorders-create-Inflammation', 'Hemostatic Disorders-induced-Diabetes Mellitus', 'Hemostatic Disorders-driven-Diabetes Mellitus', 'Cardiovascular Diseases-create-Inflammation', 'Cardiovascular Diseases-driven-Diabetes Mellitus', 'Inflammation-create-Aneurysm', 'Inflammation-driven-Diabetes Mellitus', 'Aneurysm-driven-Diabetes Mellitus', 'Exanthema-raise-Leprosy', 'Hypesthesia-generalize-Pruritus', 'Immunologic Deficiency Syndromes-play-Osteoporosis', 'Atrial Fibrillation-documented-Adrenal Insufficiency', 'Atrial Fibrillation-analysed-Diabetes Mellitus', 'Hearing Loss-contribute-Obesity', 'Infections-found-Neoplasms', 'Autoimmune Diseases-found-Neoplasms', 'Osteoporotic Fractures-treated-Neoplasms', 'Atrophy-precipitate-Death', 'Neurologic Manifestations-contribute-Heart Failure', 'Hypoglycemia-assess-Diabetes Mellitus', 'Hypoglycemia-defined-Headache Disorders, Secondary', 'Hypertension-exhibit-Hypotension', 'Death-obtained-Cardiovascular Diseases', 'Cardiovascular Diseases-emerge-Death', 'Neoplasms-develop-Death', 'Pain-support-Death', 'Lung Neoplasms-based-Neoplasms', 'Cerebral Infarction-attenuated-Atherosclerosis', 'Fibrosis-increase-Death', 'Fibrosis-treat-Communicable Diseases', 'Breast Neoplasms-include-Infertility, Female', 'Pneumonia-used-Asthma', 'Carcinogenesis-vary-Lung Neoplasms', 'Muscle Weakness-shrink-Death', 'Sarcopenia-increase-Kidney Diseases', 'Sarcopenia-increase-Chronic Kidney Disease-Mineral and Bone Disorder', 'Neoplasms-reduce-Infections', 'Enchondromatosis-develop-Neoplasm Metastasis', 'Coronary Artery Disease-computed-Myocardial Infarction', 'Pain-use-Pain Insensitivity, Congenital', 'Candidiasis-follow-Aspergillosis', 'Candidiasis-follow-Cryptococcosis', 'Vision Disorders-fall-Alzheimer Disease', 'Vision Disorders-arise-Vestibulocochlear Nerve Diseases', 'Vision Disorders-arise-Vestibular Diseases', 'Alzheimer Disease-arise-Vestibulocochlear Nerve Diseases', 'Alzheimer Disease-arise-Vestibular Diseases', 'Neoplasms-suffer-Pulmonary Disease, Chronic Obstructive', 'Paramyxoviridae Infections-associated-Respiratory Tract Infections', 'Respiratory Tract Infections-associated-Paramyxoviridae Infections', 'Pulmonary Disease, Chronic Obstructive-suffer-Paramyxoviridae Infections', 'Alzheimer Disease-focus-Atrophy', 'Alzheimer Disease-paid-Cerebrovascular Disorders', 'Atrophy-paid-Cerebrovascular Disorders', 'Macular Degeneration-measure-Pruritus', 'Prostatic Hyperplasia-found-Hereditary Breast and Ovarian Cancer Syndrome', 'Status Epilepticus-include-Aphasia', 'Status Epilepticus-include-Myoclonus', 'Status Epilepticus-include-Nystagmus, Pathologic', 'Status Epilepticus-present-Seizures', 'Idiopathic Pulmonary Fibrosis-exhibit-Drug-Related Side Effects and Adverse Reactions', 'Pain-identify-Dementia', 'Death-observed-Cardiomyopathy, Dilated', 'Psychoses, Substance-Induced-include-Dementia', 'Dementia-observed-Alzheimer Disease', 'Psychoses, Substance-Induced-observed-Alzheimer Disease', 'Infections-convert-Lung Diseases', 'Infections-diminish-Lung Diseases', 'IgA Vasculitis-reported-Mucocutaneous Lymph Node Syndrome', 'IgA Vasculitis-reported-Polymyalgia Rheumatica', 'Neurodegenerative Diseases-established-Mitochondrial Diseases', 'Drug-Related Side Effects and Adverse Reactions-select-Carcinoma, Non-Small-Cell Lung', 'Thrombosis-associated-Death, Sudden', 'Death, Sudden-associated-Thrombosis', 'Thrombosis-associated-Coronary Artery Disease', 'Coronary Artery Disease-associated-Thrombosis', 'Hemorrhage-associated-Death, Sudden', 'Death, Sudden-associated-Hemorrhage', 'Hemorrhage-associated-Coronary Artery Disease', 'Coronary Artery Disease-associated-Hemorrhage', 'Atherosclerosis-compare-Thrombosis', 'Atherosclerosis-compare-Hemorrhage', 'Coronary Artery Disease-show-Inflammation', 'Inflammation-occur-Pulmonary Disease, Chronic Obstructive', 'Crystal Arthropathies-provide-Cataract', 'Atrial Fibrillation-modify-Hypotension', 'Diabetes Mellitus, Type 2-diagnosed-Dementia', 'Hyperuricemia-predict-Cardiovascular Diseases', 'Sleep Apnea Syndromes-associated-Heart Diseases', 'Heart Diseases-associated-Sleep Apnea Syndromes', 'Osteoporosis-contribute-Heart Failure', 'Osteoporosis-result-Kyphosis', 'Osteoporosis-result-Spinal Diseases', 'Heart Failure-result-Kyphosis', 'Bone Malalignment-reveal-Pain', 'Spinal Cord Diseases-result-Neoplasms', 'Spinal Cord Diseases-result-Infections', 'Uterine Cervicitis-comprise-Spondylosis', 'Uterine Cervicitis-comprise-Joint Diseases', 'Uterine Cervicitis-comprise-Hypertrophy', 'Spondylosis-refer-Uterine Cervicitis', 'Joint Diseases-refer-Uterine Cervicitis', 'Spinal Diseases-include-Hereditary Breast and Ovarian Cancer Syndrome', 'Spinal Diseases-include-Scoliosis', 'Parkinson Disease-manage-Movement Disorders', 'Kyphosis-occur-Musculoskeletal Diseases', 'Osteoporotic Fractures-include-Spinal Diseases', 'Uterine Cervicitis-include-Spinal Diseases', 'Spinal Stenosis-include-Spinal Diseases', 'Neurodegenerative Diseases-include-Spinal Diseases', 'Constriction, Pathologic-contribute-Pain', 'Alzheimer Disease-improve-Sleep Wake Disorders', 'Aneuploidy-associated-Intellectual Disability', 'Intellectual Disability-associated-Aneuploidy', 'Aneuploidy-associated-Neurodegenerative Diseases', 'Neurodegenerative Diseases-associated-Aneuploidy', 'Cerebral Hemorrhage-contribute-Atrial Fibrillation', 'Neurologic Manifestations-play-Vascular Remodeling', 'Deglutition Disorders-considered-Neoplasms', 'Peptic Ulcer-remain-Hemorrhage', 'Ulcer-play-Dyspepsia', 'Ulcer-influence-Gastroesophageal Reflux', 'Dyspepsia-influence-Gastroesophageal Reflux', 'Ulcer-treated-Infections', 'Cardiovascular Diseases-include-Renal Insufficiency, Chronic', 'Renal Insufficiency, Chronic-associated-Infections', 'Infections-associated-Renal Insufficiency, Chronic', 'Seizures-approved-Epilepsy', 'Kidney Diseases-admitted-Heart Failure', 'Parkinson Disease-include-Muscle Rigidity', 'Parkinson Disease-include-Tremor', 'Endometrial Neoplasms-associated-Neoplasms', 'Neoplasms-associated-Endometrial Neoplasms', 'Hypertension-include-Death', 'Neoplasms-screened-Sarcopenia', 'Thrombosis-identified-Critical Illness', 'Respiratory Insufficiency-associated-Infections', 'Infections-associated-Respiratory Insufficiency', 'Respiratory Insufficiency-associated-Pulmonary Embolism', 'Pulmonary Embolism-associated-Respiratory Insufficiency', 'Delirium-influence-Hip Fractures', 'Helicobacter Infections-investigate-Pulmonary Disease, Chronic Obstructive', 'Wounds and Injuries-reviewed-Death', 'Respiratory Insufficiency-require-Shock, Septic', 'Inflammation-lessen-Death', 'Neurodegenerative Diseases-lessen-Death', 'Infarction-associated-Parkinson Disease, Secondary', 'Parkinson Disease, Secondary-associated-Infarction', 'Arteriolosclerosis-associated-Death', 'Death-associated-Arteriolosclerosis', 'Parkinson Disease, Secondary-associated-Death', 'Death-associated-Parkinson Disease, Secondary', 'Osteoporosis-related-Cerebral Infarction', 'Nervous System Diseases-contribute-Psychoses, Substance-Induced', 'Malocclusion-used-Heart Failure', 'Hypocalcemia-continue-Hypophosphatemia', 'Bone Diseases-presented-Hypocalcemia', 'Bone Diseases-presented-Hypophosphatemia', 'Bone Diseases-persist-Huntington Disease', 'Hypocalcemia-persist-Huntington Disease', 'Hypophosphatemia-persist-Huntington Disease', 'Bone Diseases-associated-Hypocalcemia', 'Hypocalcemia-associated-Bone Diseases', 'Bone Diseases-associated-Hypophosphatemia', 'Hypophosphatemia-associated-Bone Diseases', 'Diarrhea-include-Constipation', 'Diarrhea-culminate-Death', 'Intracranial Aneurysm-related-Muscle Weakness', 'Intracranial Aneurysm-associated-Muscle Weakness', 'Muscle Weakness-associated-Intracranial Aneurysm', 'Aneurysm-tend-Infarction, Middle Cerebral Artery', 'Hypoglycemia-choose-Diabetes Mellitus, Type 2', 'Hypoglycemia-choose-Diabetes Mellitus', 'Werner Syndrome-observed-Drug Hypersensitivity', 'Tremor-associated-Death', 'Death-associated-Tremor', 'Weight Loss-investigate-Obesity', 'Glucose Metabolism Disorders-lead-Amyotrophic Lateral Sclerosis', 'Tuberculosis-considered-Pneumonia', 'Atrophy-map-Parkinson Disease', 'Atrophy-map-Parkinson Disease, Secondary', 'Parkinson Disease-map-Parkinson Disease, Secondary', 'Neoplasms-provide-Leukemia, Myeloid, Acute', 'Cerebral Small Vessel Diseases-lead-Stroke', 'Malaria, Cerebral-include-Malaria', 'Anemia-include-Malaria', 'Peripheral Nervous System Diseases-include-Hypesthesia', 'Peripheral Nervous System Diseases-include-Pain', 'Peripheral Nervous System Diseases-include-Myalgia', 'Hemorrhage-reduce-Thrombocytopenia', 'Hypokinesia-associated-Lewy Body Disease', 'Lewy Body Disease-associated-Hypokinesia', 'Hypokinesia-associated-Alzheimer Disease', 'Alzheimer Disease-associated-Hypokinesia', 'Alzheimer Disease-coordinate-Parkinson Disease', 'Alzheimer Disease-identified-Hypokinesia', 'Parkinson Disease-suggest-Neurodegenerative Diseases', 'Hallucinations-show-Hypokinesia', 'Alzheimer Disease-identified-Muscle Rigidity', 'Alzheimer Disease-identified-Tremor', 'Diabetes Mellitus-associated-Arrhythmias, Cardiac', 'Arrhythmias, Cardiac-associated-Diabetes Mellitus', 'Hypoglycemia-associated-Coronary Artery Disease', 'Coronary Artery Disease-associated-Hypoglycemia', 'Hypoglycemia-associated-Arrhythmias, Cardiac', 'Arrhythmias, Cardiac-associated-Hypoglycemia', 'Hypoglycemia-associated-Stroke', 'Stroke-associated-Hypoglycemia', 'Hypoglycemia-associated-Neoplasms', 'Neoplasms-associated-Hypoglycemia', 'Hypoglycemia-recommended-Kidney Diseases', 'Hypoglycemia-recommended-Neoplasms', 'Hypoglycemia-prevent-Death', 'Kidney Diseases-prevent-Death', 'Neoplasms-prevent-Death', 'Carcinogenesis-differ-Neoplasms', 'Sarcopenia-explore-Death', 'Bone Neoplasms-contribute-Fractures, Bone', 'Bacterial Infections-aggravate-Inflammation', 'Critical Illness-observed-Osteoarthritis', 'Progeria-reduced-Cardiovascular Diseases', 'Progeria-treat-Cardiovascular Diseases', 'Pain-help-Osteoarthritis', 'Wounds and Injuries-define-Cardiac Output, Low', 'Mitochondrial Diseases-inherit-Movement Disorders', 'Atrial Fibrillation-contribute-Cerebral Infarction', 'Inflammation-associate-Alzheimer Disease', 'Alzheimer Disease-associate-Inflammation', 'Hypertension-associated-Intracranial Hemorrhages', 'Intracranial Hemorrhages-associated-Hypertension', 'Diabetes Mellitus-associated-Intracranial Hemorrhages', 'Intracranial Hemorrhages-associated-Diabetes Mellitus', 'Cardiac Output, High-undergo-Renal Insufficiency', 'Hernia-fell-Airway Obstruction', 'Adenoma-nonfunction-Pituitary Neoplasms', 'Amyotrophic Lateral Sclerosis-correlate-Fasciculation', 'Dementia-challenge-Pain', 'Chronic Disease-delay-Dementia', 'Aneurysm-investigated-Rupture', 'Aneurysm-identify-Rupture', 'Rupture-occur-Aneurysm', 'Pelvic Floor Disorders-undergo-Urinary Incontinence, Stress', 'Acidosis-counteract-Calcinosis', 'Calcinosis-reverse-Hyperphosphatemia', 'Alzheimer Disease-learne-Memory Disorders', 'Alzheimer Disease-associated-Ovarian Diseases', 'Ovarian Diseases-associated-Alzheimer Disease', 'Neoplasms-followed-Hematologic Neoplasms', 'Neoplasms-classify-Death', 'Cardiovascular Diseases-suffer-Vision Disorders', 'Anophthalmos-develop-Blindness', 'Keratosis, Actinic-progress-Skin Neoplasms', 'Ocular Hypertension-decrease-Anophthalmos', 'Hypoxia-occur-Sleep Apnea, Obstructive', 'Hypoxia-occur-Alzheimer Disease', 'Hypertension-occur-Sleep Apnea, Obstructive', 'Hypertension-occur-Alzheimer Disease', 'Inflammation-occur-Sleep Apnea, Obstructive', 'Renal Insufficiency, Chronic-contribute-Cardiovascular Diseases', 'Sleep Apnea, Obstructive-trigger-Crohn Disease', 'Sleep Apnea, Obstructive-enhance-Hypertension', 'Sleep Apnea, Obstructive-treat-Alzheimer Disease', 'Sleep Apnea, Obstructive-promote-Atrophy', 'Sleep Apnea, Obstructive-associated-Memory Disorders', 'Memory Disorders-associated-Sleep Apnea, Obstructive', 'Alzheimer Disease-contribute-Inflammation', 'Alzheimer Disease-support-Neurodegenerative Diseases', 'Pain-associated-Skin Ulcer', 'Skin Ulcer-associated-Pain', 'Diabetes Mellitus-describe-Ulcer', 'Diabetes Mellitus-describe-Pain', 'Diabetes Mellitus-suffer-Pain', 'Ulcer-suffer-Pain', 'Pain-report-Muscle Weakness', 'Infections-suggest-Urinary Bladder Diseases', 'Pulmonary Disease, Chronic Obstructive-show-Osteoporotic Fractures', 'Acute Pain-use-Hemorrhage', 'Hearing Loss-associated-Fatigue', 'Fatigue-associated-Hearing Loss', 'Drug-Related Side Effects and Adverse Reactions-induce-Neoplasms', 'Inflammation-dysregulate-Hematologic Diseases', 'Inflammation-damage-Hematologic Diseases', 'Inflammation-dysregulate-Retinal Diseases', 'Inflammation-lead-Retinal Diseases', 'Hypovolemia-result-Kidney Diseases', 'Hypovolemia-result-Acute Kidney Injury', 'Hypovolemia-lead-Acute Kidney Injury', 'Hyperandrogenism-diagnosed-Ovarian Neoplasms', 'Diabetes Mellitus-adjusted-Hypoglycemia', 'Sarcopenia-associated-Peptic Ulcer', 'Peptic Ulcer-associated-Sarcopenia', 'Diabetes Mellitus-increase-Sarcopenia', 'Peptic Ulcer-increase-Sarcopenia', 'Precursor Cell Lymphoblastic Leukemia-Lymphoma-diagnosed-Neoplasms', 'Pericardial Effusion-develop-Pericarditis', 'Brugada Syndrome-associated-Tachycardia, Ventricular', 'Tachycardia, Ventricular-associated-Brugada Syndrome', 'Brugada Syndrome-associated-Ventricular Fibrillation', 'Ventricular Fibrillation-associated-Brugada Syndrome', 'Immunologic Deficiency Syndromes-produce-Arrhythmias, Cardiac', 'Breast Neoplasms, Male-produce-Arrhythmias, Cardiac', 'Cystic Fibrosis-related-Diabetes Mellitus', 'Cystic Fibrosis-affect-Diabetes Mellitus', 'Movement Disorders-progress-Hyperkinesis', 'Dysphonia-decrease-Laryngitis', 'Paralysis-decrease-Laryngitis', 'Laryngitis-diagnose-Dysphonia', 'Sarcoidosis-lead-Blindness', 'Atrial Fibrillation-report-Heart Defects, Congenital', 'Ischemia-occur-Atrial Fibrillation', 'Tachycardia, Supraventricular-coexist-Atrial Fibrillation', 'Arthritis, Infectious-differentiate-Arthritis', 'Neck Pain-considered-Arthritis, Infectious', 'Communicable Diseases-represent-Encephalitis', 'Musculoskeletal Pain-become-Nervous System Diseases', 'Musculoskeletal Pain-become-Tinnitus', 'Hepatitis C-impact-Kidney Diseases', 'Death-fall-Fractures, Bone', 'Primary Ovarian Insufficiency-influence-Ovarian Diseases', 'Hypogonadism-report-Erectile Dysfunction', 'Vaccinia-protect-Respiratory Tract Infections', 'Ulcer-assessed-Osteoporosis', 'Retinal Telangiectasis-treat-Coronary Vessel Anomalies', 'Retinal Telangiectasis-emerge-Coronary Vessel Anomalies', 'Diabetes Mellitus-admitted-Metabolic Diseases', 'Multiple Myeloma-categorized-Death', 'Hypertension-grow-Death', 'Seizures-show-Urinary Incontinence', 'Alzheimer Disease-offer-Neurodegenerative Diseases', 'Urinary Incontinence-increase-Obesity', 'Macrophage Activation Syndrome-play-Neoplasms', 'Macrophage Activation Syndrome-play-Atherosclerosis', 'Macrophage Activation Syndrome-play-Anophthalmos', 'Obesity-suggest-Osteoarthritis', 'Pain-affected-Obesity', 'Obesity-suggest-Fasciitis, Plantar', 'Ankle Injuries-reduced-Obesity', 'Hand Injuries-seen-Dupuytren Contracture', 'Diabetes Mellitus-associated-Hand Injuries', 'Hand Injuries-associated-Diabetes Mellitus', 'Hypertension-associated-Dupuytren Contracture', 'Dupuytren Contracture-associated-Hypertension', 'Dupuytren Contracture-associated-Retinal Diseases', 'Retinal Diseases-associated-Dupuytren Contracture', 'Anemia-manifest-Postpartum Hemorrhage', 'Retinal Diseases-associated-Hand Injuries', 'Hand Injuries-associated-Retinal Diseases', 'Retinal Diseases-associated-Diabetes Mellitus, Type 2', 'Diabetes Mellitus, Type 2-associated-Retinal Diseases', 'Hypertension-associated-Hand Injuries', 'Hand Injuries-associated-Hypertension', 'Immunologic Deficiency Syndromes-lead-Bone Neoplasms', 'Fistula-associated-Amnesia', 'Amnesia-associated-Fistula', 'Head and Neck Neoplasms-associated-Infections', 'Infections-associated-Head and Neck Neoplasms', 'Head and Neck Neoplasms-associated-Neoplasms', 'Neoplasms-associated-Head and Neck Neoplasms', 'Acidosis-lead-Multiple Organ Failure', 'Acidosis-lead-Death', 'Heart Failure-cause-Mitochondrial Diseases', 'Heart Failure-cause-Heart Diseases', 'Heart Failure-cause-Opportunistic Infections', 'Heart Failure-cause-Alcoholism', 'Heart Failure-cause-Immunologic Deficiency Syndromes', 'Infections-transform-Chronic Disease', 'Urinary Incontinence-associated-Bronchitis', 'Bronchitis-associated-Urinary Incontinence', 'Urinary Incontinence-associated-Asthma', 'Asthma-associated-Urinary Incontinence', 'Urinary Incontinence-associated-Stroke', 'Stroke-associated-Urinary Incontinence', 'Wounds and Injuries-increase-Pseudomonas Infections', 'Death-increase-Pseudomonas Infections', 'Death-combined-Coinfection', 'Acquired Immunodeficiency Syndrome-live-Coronary Artery Disease', 'Inflammation-cause-Papilledema', 'Papilledema-cause-Retinitis', 'Atrophy-correlate-Hearing Loss, Central', 'Pain-identify-Osteoarthritis', 'Death-recognized-Diabetes Mellitus', 'Diabetes Mellitus-recognized-Bacterial Infections', 'Diabetes Mellitus-recognized-Neoplasms', 'Prostatic Hyperplasia-coexist-Hypertension', 'Bone Diseases, Metabolic-include-Malnutrition', 'Tendinopathy-associated-Pain', 'Pain-associated-Tendinopathy', 'Inflammation-account-Dry Eye Syndromes', 'Dementia-compared-Death', 'Fractures, Bone-undergo-Hip Fractures', 'Atherosclerosis-relate-Stroke', 'Atherosclerosis-relate-Brain Infarction', 'Atherosclerosis-relate-Leukoaraiosis', 'Atherosclerosis-relate-Dementia', 'Cardiovascular Diseases-increase-Obesity', 'Carotid Stenosis-account-Cerebral Infarction', 'Neoplasms-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-Neoplasms', 'Neoplasms-associated-Cardiotoxicity', 'Cardiotoxicity-associated-Neoplasms', 'Cardiotoxicity-reduce-Death', 'Alzheimer Disease-known-Neurodegenerative Diseases', 'Neurodegenerative Diseases-known-Dementia', 'Parkinson Disease, Secondary-found-Lewy Body Disease', 'Parkinson Disease, Secondary-found-Alzheimer Disease', 'Parkinson Disease, Secondary-found-Hydrocephalus', 'Osteonecrosis-require-Fractures, Bone', 'Dementia-include-Anorexia', 'Acidosis-exist-Hypertension', 'Death-increase-Ovarian Diseases', 'Obesity-mediate-Inflammation', 'Immunologic Deficiency Syndromes-accelerate-Alzheimer Disease', 'Neoplasms-reveal-Neoplasms, Neuroepithelial', 'Hereditary Breast and Ovarian Cancer Syndrome-devise-Sarcopenia', 'Hereditary Breast and Ovarian Cancer Syndrome-devise-Osteoporosis', 'Sarcopenia-report-Fractures, Bone', 'Hypertrophy, Left Ventricular-attenuated-Metabolic Syndrome', 'Pain, Postoperative-use-Knee Injuries', 'Pain, Postoperative-use-Osteoarthritis', 'Thrombosis-associated-Venous Insufficiency', 'Venous Insufficiency-associated-Thrombosis', 'Thrombosis-associated-Ulcer', 'Ulcer-associated-Thrombosis', 'Thrombosis-associated-Edema', 'Edema-associated-Thrombosis', 'Venous Insufficiency-assessed-Thrombosis', 'Pulmonary Embolism-carry-Death', 'Thromboembolism-carry-Death', 'Leg Ulcer-associated-Thrombosis', 'Thrombosis-associated-Leg Ulcer', 'Death-indicate-Rheumatic Heart Disease', 'Wounds and Injuries-identify-Critical Illness', 'Myositis-characterized-Muscle Weakness', 'Neoplasms-resemble-Death', 'Ventricular Remodeling-inhibit-Heart Failure', 'Hypertrophy-attenuate-Fibrosis', 'Arthritis, Rheumatoid-include-Neoplasms', 'Arthritis, Rheumatoid-include-Inflammation', 'Pneumonia, Aspiration-develop-Gastric Outlet Obstruction', 'Pneumonia, Aspiration-develop-Hernia, Hiatal', 'Death-remain-Infections', 'Hypogonadism-show-Osteoporosis', 'Hypogonadism-show-Fractures, Bone', 'Turner Syndrome-show-Osteoporosis', 'Turner Syndrome-show-Fractures, Bone', 'Chromosome Aberrations-derive-Immunologic Deficiency Syndromes', 'Dementia-examine-Alzheimer Disease', 'Cerebrovascular Disorders-compare-Alzheimer Disease', 'Dementia-examine-Cerebrovascular Disorders', 'Bone Marrow Diseases-scored-Osteoarthritis, Knee', 'Retinal Degeneration-observed-Parkinson Disease', 'Parkinson Disease-remain-Drug-Related Side Effects and Adverse Reactions', 'Death-become-Hypertension', 'Pulmonary Disease, Chronic Obstructive-associated-Ocular Motility Disorders', 'Ocular Motility Disorders-associated-Pulmonary Disease, Chronic Obstructive', 'Fibrosis-increase-Atrial Fibrillation', 'Pain-include-Arthritis', 'Pain-include-Lung Diseases', 'Retinal Diseases-cause-Blindness', 'Myelodysplastic Syndromes-contribute-Sotos Syndrome', 'Fatigue-propose-Frailty', 'Pain-present-Fractures, Bone', 'Liver Diseases-evaluate-Carcinoma, Hepatocellular', 'Epilepsy, Temporal Lobe-associated-Dementia', 'Dementia-associated-Epilepsy, Temporal Lobe', 'HIV Infections-living-Infections', 'Chronic Disease-living-Infections', 'Death-investigated-Renal Insufficiency, Chronic', 'Osteoarthritis-linked-HIV Infections', 'Osteoarthritis-confronted-Chronic Pain', 'Carcinoma, Hepatocellular-rank-Neoplasms', 'Carcinoma, Hepatocellular-observed-Neoplasms', 'Carcinoma, Hepatocellular-rank-Death', 'Carcinoma, Hepatocellular-weaken-Chronic Disease', 'Carcinoma, Hepatocellular-undergo-Neoplasms', 'Pulmonary Disease, Chronic Obstructive-associated-Pneumonia, Pneumocystis', 'Pneumonia, Pneumocystis-associated-Pulmonary Disease, Chronic Obstructive', 'Pulmonary Disease, Chronic Obstructive-confer-Respiratory Tract Infections', 'Pain-respond-Neurodegenerative Diseases', 'Dementia-related-Delirium', 'Dementia-related-Pneumonia', 'Vision Disorders-associated-Chest Pain', 'Chest Pain-associated-Vision Disorders', 'Chest Pain-include-Coronary Artery Disease', 'Hypothyroidism-treat-Death', 'Sarcopenia-characterized-Obesity', 'Sialic Acid Storage Disease-associated-Fractures, Bone', 'Fractures, Bone-associated-Sialic Acid Storage Disease', 'Disease-remain-Dementia', 'Hypoxia-include-Dementia', 'Neurodegenerative Diseases-include-Dementia', 'Wounds and Injuries-associated-Psoriasis', 'Psoriasis-associated-Wounds and Injuries', 'Inflammation-linked-Renal Insufficiency, Chronic', 'Inflammation-linked-Immune System Diseases', 'Inflammation-linked-Infections', 'Death-linked-Renal Insufficiency, Chronic', 'Renal Insufficiency, Chronic-linked-Immune System Diseases', 'Renal Insufficiency, Chronic-linked-Infections', 'Death-linked-Immune System Diseases', 'Death-linked-Cardiovascular Diseases', 'Infections-suffer-Neoplasms', 'Renal Insufficiency, Chronic-improve-Inflammation', 'Renal Insufficiency, Chronic-improve-Cardiovascular Diseases', 'Inflammation-appear-Renal Insufficiency, Chronic', 'Urinary Tract Infections-include-Infections', 'Neoplasms-suffer-Urinary Tract Infections', 'Neoplasms-suffer-Osteomyelitis', 'Arthritis, Rheumatoid-regarded-Inflammation', 'Microsatellite Instability-trigger-Carcinogenesis', 'Prostatitis-associated-Arthritis, Rheumatoid', 'Arthritis, Rheumatoid-associated-Prostatitis', 'Liver Failure-suggest-Fibrosis', 'Diabetes Mellitus-become-Fibrosis', 'Obesity-become-Fibrosis', 'Arthritis-cause-IgA Vasculitis', 'Arthritis-cause-Death', 'Osteoarthritis-include-Arthritis', 'Arthritis, Rheumatoid-include-Arthritis', 'Spondylitis, Ankylosing-include-Arthritis', 'Cardiac Output, Low-associated-Urinary Incontinence', 'Urinary Incontinence-associated-Cardiac Output, Low', 'Brain Injuries, Traumatic-sustain-Death', 'Death-followed-Thrombosis', 'Death-followed-Infections', 'Death-followed-Rupture', 'Diabetes Mellitus-test-Encephalitis, California', 'Heart Failure-complicated-Hypertension', 'Heart Failure-complicated-Diabetes Mellitus', 'Osteoporosis-outweigh-Fractures, Bone', 'Osteoporosis-directed-Bone Neoplasms', 'Neoplasms-classify-Carcinogenesis', 'Osteonecrosis-include-Osteoporotic Fractures', 'Ventricular Dysfunction, Left-defined-Sarcopenia', 'Sinusitis-precede-Olfaction Disorders', 'Alzheimer Disease-precede-Olfaction Disorders', 'Olfaction Disorders-precede-Dementia', 'Metabolic Syndrome-act-Diabetes Mellitus', 'Hyperglycemia-associated-Diabetes Mellitus, Type 1', 'Diabetes Mellitus, Type 1-associated-Hyperglycemia', 'Microvascular Angina-associated-Diabetes Mellitus, Type 1', 'Diabetes Mellitus, Type 1-associated-Microvascular Angina', 'Osteoporosis-grow-Fractures, Bone', 'Fractures, Bone-show-Sarcoma, Clear Cell', 'Osteoporotic Fractures-include-Osteoporosis', 'Osteoporosis-associated-Bone Neoplasms', 'Bone Neoplasms-associated-Osteoporosis', 'Fatigue-overlap-Neoplasms', 'Skin Diseases-include-Hemangioma', 'Skin Diseases-include-Edema', 'Skin Diseases-include-Pruritus', 'Edema-suffer-Psoriasis', 'Onychomycosis-suffer-Psoriasis', 'Diabetes Mellitus-associated-Onychomycosis', 'Onychomycosis-associated-Diabetes Mellitus', 'Diabetes Mellitus-promote-Hypercholesterolemia', 'Diabetes Mellitus-promote-Xanthomatosis', 'Diabetes Mellitus-associated-Purpura', 'Purpura-associated-Diabetes Mellitus', 'Diabetes Mellitus-favor-Hypothyroidism', 'Onychomycosis-promote-Hypercholesterolemia', 'Onychomycosis-associated-Pulmonary Disease, Chronic Obstructive', 'Pulmonary Disease, Chronic Obstructive-associated-Onychomycosis', 'Onychomycosis-favor-Hypothyroidism', 'Hypercholesterolemia-promote-Xanthomatosis', 'Hypercholesterolemia-associated-Pulmonary Disease, Chronic Obstructive', 'Pulmonary Disease, Chronic Obstructive-associated-Hypercholesterolemia', 'Endometrial Neoplasms-related-Neoplasms', 'Hypercholesterolemia-associated-Purpura', 'Purpura-associated-Hypercholesterolemia', 'Hypercholesterolemia-favor-Hypothyroidism', 'Xanthomatosis-associated-Pulmonary Disease, Chronic Obstructive', 'Pulmonary Disease, Chronic Obstructive-associated-Xanthomatosis', 'Xanthomatosis-associated-Purpura', 'Purpura-associated-Xanthomatosis', 'Xanthomatosis-favor-Hypothyroidism', 'Pulmonary Disease, Chronic Obstructive-associated-Purpura', 'Purpura-associated-Pulmonary Disease, Chronic Obstructive', 'Pulmonary Disease, Chronic Obstructive-favor-Hypothyroidism', 'Purpura-favor-Hypothyroidism', 'Neoplasms-suppress-Inflammation', 'Arrhythmias, Cardiac-associated-Thromboembolism', 'Thromboembolism-associated-Arrhythmias, Cardiac', 'Metabolic Syndrome-describe-Diabetes Mellitus', 'Metabolic Syndrome-describe-Hypertension', 'Liver Diseases-related-Hepatitis C', 'Metabolic Syndrome-describe-Obesity', 'Metabolic Syndrome-describe-Dyslipidemias', 'Metabolic Syndrome-describe-Cardiovascular Diseases', 'Asthma-associated-Dysphonia', 'Dysphonia-associated-Asthma', 'Pulmonary Disease, Chronic Obstructive-associated-Dysphonia', 'Dysphonia-associated-Pulmonary Disease, Chronic Obstructive', 'Aneurysm-induced-Hyperlipoproteinemia Type II', 'Thyroid Diseases-associated-Dysphonia', 'Dysphonia-associated-Thyroid Diseases', 'Hepatitis C-point-Infections', 'Intracranial Aneurysm-grow-Rupture', 'Death-meet-Neoplasms', 'Death-meet-Colonic Neoplasms', 'Death-meet-Melanoma', 'Neoplasms-meet-Melanoma', 'Neoplasms-meet-Death', 'Cardiovascular Diseases-accelerated-Hypertension', 'Hypoxia-associated-Cachexia', 'Cachexia-associated-Hypoxia', 'Aneurysm-become-Neoplasms', 'Sacroiliitis-included-Spondylitis, Ankylosing', 'Spondylitis, Ankylosing-focused-Oculocerebrorenal Syndrome', 'Inflammation-described-Back Pain', 'Blood Loss, Surgical-identified-Stomach Neoplasms', 'Deglutition Disorders-increase-Death', 'Lipoma-induced-Obesity', 'Cardiovascular Diseases-detected-Anemia, Sickle Cell', 'Blindness-related-Glaucoma', 'Death-suffer-Intracranial Hemorrhages', 'Syncope-carry-Death', 'Hypotension, Orthostatic-account-Syncope', 'Hypotension, Orthostatic-account-Arrhythmias, Cardiac', 'Syncope-account-Arrhythmias, Cardiac', 'Diabetes Mellitus-aging-Obesity', 'Diabetes Mellitus-aging-Heart Diseases', 'Diabetes Mellitus-aging-Hypertension', 'Death-found-Neurodegenerative Diseases', 'Neurologic Manifestations-improve-Retinal Degeneration', 'Arthralgia-induce-Osteoarthritis', 'Infections-rendered-Death', 'Pain-maintain-Osteoarthritis', 'Sexual Dysfunction, Physiological-compared-Hypothyroidism', 'Infections-feared-Death', 'Neurodegenerative Diseases-increase-Osteoarthritis', 'Cerebral Amyloid Angiopathy-lead-Dementia', 'Headache-contrast-Intracranial Hemorrhages', 'Cerebral Amyloid Angiopathy-distinguished-Headache', 'Seizures-contrast-Intracranial Hemorrhages', 'Cerebral Amyloid Angiopathy-distinguished-Seizures', 'Stroke-contrast-Intracranial Hemorrhages', 'Cerebral Amyloid Angiopathy-distinguished-Stroke', 'Cerebral Amyloid Angiopathy-seen-Intracranial Hemorrhages', 'Leukoencephalopathies-evaluate-Carotid Artery Diseases', 'Autoimmune Hypophysitis-thought-Autoimmune Diseases', 'Pituitary Diseases-thought-Autoimmune Diseases', 'Hip Fractures-compare-Fractures, Bone', 'Neoplasms-develop-Infections', 'Epilepsies, Partial-approved-Seizures', 'Epilepsies, Partial-approved-Epilepsy', 'Epilepsy-approved-Seizures', 'Epilepsy, Absence-associated-Inflammation', 'Inflammation-associated-Epilepsy, Absence', 'Parkinsonian Disorders-affected-Neurodegenerative Diseases', 'Parkinsonian Disorders-differentiate-Nervous System Diseases', 'Neurodegenerative Diseases-differentiate-Nervous System Diseases', 'Carcinoma, Squamous Cell-followed-Urinary Bladder Neoplasms', 'Urinary Bladder Calculi-followed-Urinary Bladder Neoplasms', 'Carcinoma, Squamous Cell-related-Urinary Bladder Calculi', 'Status Epilepticus-remain-Death', 'Heart Failure-increase-Cachexia', 'Heart Failure-improve-Weight Loss', 'Renal Insufficiency, Chronic-increase-Cachexia', 'Renal Insufficiency, Chronic-improve-Weight Loss', 'Cachexia-play-Renal Insufficiency, Chronic', 'Cachexia-improve-Weight Loss', 'Constipation-excluded-Pelvic Floor Disorders', 'Hematoma-considered-Nutrition Disorders', 'Purpura-considered-Nutrition Disorders', 'Osteoporotic Fractures-considered-Fractures, Bone', 'Inflammation-enhanced-Alzheimer Disease', 'Inflammation-enhanced-Cardiovascular Diseases', 'Inflammation-implicated-Diabetes Mellitus', 'Inflammation-enhanced-Diabetes Mellitus', 'Arthritis, Rheumatoid-linked-Alzheimer Disease', 'Arthritis, Rheumatoid-linked-Bone Diseases', 'Periodontitis-linked-Alzheimer Disease', 'Periodontitis-linked-Bone Diseases', 'Nervous System Diseases-seen-Alzheimer Disease', 'Alzheimer Disease-linked-Bone Diseases', 'Obesity-include-Diabetes Mellitus, Type 2', 'HIV Infections-result-Neoplasms', 'Kidney Failure, Chronic-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-Kidney Failure, Chronic', 'Kidney Failure, Chronic-associated-Hypertension', 'Hypertension-associated-Kidney Failure, Chronic', 'Neoplasms-associate-HIV Infections', 'HIV Infections-associate-Neoplasms', 'Neoplasms-remain-HIV Infections', 'Neoplasms-remain-Melanoma', 'HIV Infections-associate-Hypertension', 'Hypertension-associate-HIV Infections', 'HIV Infections-remain-Hypertension', 'HIV Infections-associate-Death', 'Death-associate-HIV Infections', 'HIV Infections-associate-Melanoma', 'Melanoma-associate-HIV Infections', 'HIV Infections-remain-Melanoma', 'Hypertension-remain-Melanoma', 'Death-remain-Melanoma', 'Renal Insufficiency, Chronic-moderated-Hypertension', 'Death-identify-Hematoma', 'Polydipsia-differentiate-Polyuria', 'Dementia-follow-Hip Fractures', 'Cerebellar Diseases-show-Somatosensory Disorders', 'Sleep Apnea Syndromes-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-Sleep Apnea Syndromes', 'Prostatitis-known-Prostatic Hyperplasia', 'Hydrocephalus-occur-Dementia', 'Cardiovascular Diseases-confounded-Aortic Diseases', 'Hydrocephalus-occur-Airway Obstruction', 'Fatigue-influence-Parkinson Disease', 'Muscular Dystrophy, Duchenne-reduce-Fractures, Bone', 'Hypertension-accompany-Diabetes Mellitus', 'Hypertension-defined-Renal Insufficiency, Chronic', 'Bronchiolitis-include-Respiratory Tract Diseases', 'Myositis-correlate-Muscle Weakness', 'Autoimmune Diseases-known-Myositis', 'Myositis-see-Sepsis', 'Weight Loss-predict-Death', 'Weight Loss-predict-Sensation Disorders', 'Arrhythmias, Cardiac-implement-Atrial Fibrillation', 'Stroke-implement-Atrial Fibrillation', 'Stroke-known-Arrhythmias, Cardiac', 'Cardiovascular Diseases-termed-Metabolic Syndrome', 'Hypertension-termed-Metabolic Syndrome', 'Diabetes Mellitus-termed-Metabolic Syndrome', 'Dyslipidemias-termed-Metabolic Syndrome', 'Cardiovascular Diseases-mediated-Metabolic Syndrome', 'Communicable Diseases-linked-Metabolic Diseases', 'Metabolic Syndrome-mediate-Cardiovascular Diseases', 'Communicable Diseases-linked-Neoplasms', 'Atherosclerosis-progress-Coronary Artery Disease', 'Tendinopathy-found-Retinal Degeneration', 'Diabetes Mellitus-show-Retinal Degeneration', 'Vision Disorders-lost-Alzheimer Disease', 'Syncope-compare-Drug Hypersensitivity', 'Atrial Fibrillation-underlie-Stroke', 'Stroke-reviewed-Atrial Fibrillation', 'Hemorrhage-reviewed-Atrial Fibrillation', 'Atrial Fibrillation-reviewed-Stroke', 'Diabetes Mellitus-increase-Frailty', 'Optic Nerve Diseases-use-Neurodegenerative Diseases', 'Nervous System Diseases-compared-Ocular Hypertension', 'Nervous System Diseases-compared-Glaucoma', 'Mitochondrial Diseases-implicated-Neurodegenerative Diseases', 'Mitochondrial Diseases-withstand-Optic Nerve Injuries', 'Neurodegenerative Diseases-withstand-Optic Nerve Injuries', 'Hypernatremia-used-Dehydration', 'Death-approximate-Shock, Cardiogenic', 'Death-appear-Shock, Septic', 'Emphysema-become-Cystic Fibrosis', 'Death-evaluate-Subarachnoid Hemorrhage', 'Cardiovascular Diseases-overrepresented-Death', 'Cerebrovascular Disorders-overrepresented-Death', 'Aneurysm-recovering-Subarachnoid Hemorrhage', 'Metabolic Diseases-associated-Delirium', 'Delirium-associated-Metabolic Diseases', 'Infarction-classified-Stroke, Lacunar', 'Inflammation-result-Chorioamnionitis', 'Inflammation-result-Depression, Postpartum', 'Inflammation-seem-Bronchopulmonary Dysplasia', 'Laryngitis-associated-Gastroesophageal Reflux', 'Gastroesophageal Reflux-associated-Laryngitis', 'Cerebral Infarction-exhibit-Nerve Degeneration', 'Vision Disorders-accompanied-Pupil Disorders', 'Death-result-Wounds and Injuries', 'Adrenal Insufficiency-appear-Atherosclerosis', 'Vertebrobasilar Insufficiency-appear-Atherosclerosis', 'Atherosclerosis-appear-Diabetes Mellitus', 'Glomerulonephritis-considered-Kidney Diseases', 'Hip Fractures-face-Death', 'Death-face-Hip Fractures', 'Bone Neoplasms-affect-Fractures, Bone', 'Obesity-shifting-Diabetes Mellitus', 'Multiple Organ Failure-include-Chronic Disease', 'Cardiomyopathy, Dilated-associated-Death', 'Death-associated-Cardiomyopathy, Dilated', 'Cerebral Hemorrhage-correlated-Rhinitis, Allergic', 'Cerebral Hemorrhage-correlated-Diabetes Mellitus', 'Cerebral Hemorrhage-correlated-Hypertension', 'Cerebral Hemorrhage-correlated-Coronary Artery Disease', 'Cerebral Hemorrhage-correlated-Hyperlipidemias', 'Cerebral Hemorrhage-correlated-Renal Insufficiency, Chronic', 'Osteomyelitis-increase-Cerebral Hemorrhage', 'Cerebral Hemorrhage-associated-Osteomyelitis', 'Osteomyelitis-associated-Cerebral Hemorrhage', 'Cerebral Hemorrhage-associated-Renal Insufficiency, Chronic', 'Renal Insufficiency, Chronic-associated-Cerebral Hemorrhage', 'Cerebral Hemorrhage-associated-Substance-Related Disorders', 'Substance-Related Disorders-associated-Cerebral Hemorrhage', 'Hypertension-include-Osteomyelitis', 'Diabetes Mellitus-include-Osteomyelitis', 'Osteomyelitis-lack-Cerebral Hemorrhage', 'Hyperlipidemias-include-Osteomyelitis', 'Renal Insufficiency, Chronic-include-Osteomyelitis', 'Substance-Related Disorders-include-Osteomyelitis', 'Cerebral Infarction-develop-Myocardial Infarction', 'Diabetes Mellitus-increased-Glaucoma, Open-Angle', 'Liver Diseases-treated-Metabolic Syndrome', 'Cardiovascular Diseases-moderated-Inflammation', 'Diabetes Mellitus-expected-Alzheimer Disease', 'Angina Pectoris-related-Coronary Artery Disease', 'Infections-present-Liver Diseases', 'Dementia-develop-Postoperative Cognitive Complications', 'Alzheimer Disease-give-Glucosephosphate Dehydrogenase Deficiency', 'Parkinson Disease-considered-Alzheimer Disease', 'Parkinson Disease-affect-Dementia', 'Infarction-affect-Hypothalamic Neoplasms', 'Neoplasms-affect-Hypothalamic Neoplasms', 'Hypogonadism-predicted-Obesity', 'Hypogonadism-predicted-Weight Gain', 'Obesity-predicted-Weight Gain', 'Hypogonadism-predicted-Weight Loss', 'Infarction-co-occur-Migraine Disorders', 'Babesiosis-share-Malaria', 'Immunologic Deficiency Syndromes-linked-Multiple Sclerosis', 'Immunologic Deficiency Syndromes-linked-Hypertension', 'Immunologic Deficiency Syndromes-linked-Cardiovascular Diseases', 'Death-follow-Spinal Cord Injuries', 'Glycogen Storage Disease Type II-compare-Osteoarthritis', 'Glycogen Storage Disease Type II-compare-Arthritis, Rheumatoid', 'Osteoarthritis-compare-Glycogen Storage Disease Type II', 'Arthritis, Rheumatoid-compare-Glycogen Storage Disease Type II', 'Arthritis-consider-Glycogen Storage Disease Type II', 'Arthritis, Infectious-develop-Infections', 'Hemiplegia-suffer-Stroke', 'Herpes Zoster-exit-Heart Arrest', 'Diabetic Nephropathies-include-Kidney Diseases', 'Anemia-include-Cardiovascular Diseases', 'Dyslipidemias-include-Renal Insufficiency, Chronic', 'Inflammation-include-Renal Insufficiency, Chronic', 'Metabolic Diseases-include-Renal Insufficiency, Chronic', 'Coronary Artery Disease-develop-Cardiovascular Diseases', 'Cardiomyopathy, Hypertrophic-develop-Cardiovascular Diseases', 'Hypertension-show-Renal Insufficiency, Chronic', 'Diabetes Mellitus-show-Renal Insufficiency, Chronic', 'Dyslipidemias-show-Renal Insufficiency, Chronic', 'Metabolic Diseases-show-Renal Insufficiency, Chronic', 'Cardiovascular Diseases-show-Renal Insufficiency, Chronic', 'Rickettsia Infections-contribute-Carcinoma', 'Rickettsia Infections-contribute-Fever', 'Breast Neoplasms-bring-Death', 'HIV Infections-infected-Hepatitis C', 'Death-include-Alzheimer Disease', 'Death-contribute-Alzheimer Disease', 'Death-make-Alzheimer Disease', 'Heart Valve Diseases-result-Heart Failure', 'Dementia-provide-Alzheimer Disease', 'Infarction-predicted-Diabetes Mellitus', 'Atrial Fibrillation-incur-Stroke', 'Stroke-prevent-Intracranial Hemorrhages', 'Psychoses, Substance-Induced-reduce-Death', 'Osteoarthritis-relieve-Pain', 'Cardiac Output, Low-fall-Chronic Disease', 'Alzheimer Disease-increase-Death', 'Ovarian Diseases-occur-Diabetes Mellitus', 'Diabetes Mellitus-treat-Neoplasms', 'Diabetes Mellitus-use-Dementia', 'Obesity, Metabolically Benign-reduce-Osteoporosis', 'Cholecystitis, Acute-suggest-Death', 'Pelvic Neoplasms-compare-Rectal Diseases', 'Femoral Fractures-associated-Pain', 'Pain-associated-Femoral Fractures', 'Femoral Fractures-associated-Musculoskeletal Diseases', 'Musculoskeletal Diseases-associated-Femoral Fractures', 'Femoral Fractures-associated-Hemorrhage', 'Hemorrhage-associated-Femoral Fractures', 'Diabetes Mellitus-associated-Stroke, Lacunar', 'Stroke, Lacunar-associated-Diabetes Mellitus', 'Carcinoma, Non-Small-Cell Lung-result-Respiratory Distress Syndrome', 'Diabetes Mellitus, Type 2-render-Dementia', 'Death-increase-Rheumatic Heart Disease', 'Death-increase-Atrial Fibrillation', 'Neuroblastoma-associated-Central Nervous System Diseases', 'Central Nervous System Diseases-associated-Neuroblastoma', 'Death-driven-Cardiovascular Diseases', 'Death-driven-Chronic Disease', 'Death-driven-Neoplasms', 'Death-driven-Fractures, Bone', 'Neoplasms-informed-Death', 'Neoplasms-informed-Pain', 'Neoplasms-informed-Nausea', 'Spinal Cord Diseases-present-Neuromyelitis Optica', 'Postoperative Cognitive Complications-progress-Nervous System Diseases', 'Drug Hypersensitivity-associated-Asthma', 'Asthma-associated-Drug Hypersensitivity', 'Drug Hypersensitivity-associated-Eczema', 'Eczema-associated-Drug Hypersensitivity', 'Cardiovascular Diseases-contribute-Hearing Loss', 'Diabetes Mellitus-prevent-Hearing Loss', 'Seizures-increase-Status Epilepticus', 'Heart Failure-constitute-Death', 'Polyps-demonstrate-Colonic Neoplasms', 'Delirium-perform-Vision Disorders', 'Inflammation-relate-Death', 'Leukemia, Myeloid, Acute-attributed-Neoplasms', 'Prostatic Neoplasms-distinguish-Adenocarcinoma', 'Adenocarcinoma-distinguish-Prostatic Hyperplasia', 'Cardiovascular Diseases-treat-Flushing', 'Disease-belong-Neuroacanthocytosis', 'Chromosome Disorders-arise-Muscular Dystrophy, Duchenne', 'Chromosome Disorders-arise-Immunologic Deficiency Syndromes', 'Alcoholism-cause-Cerebellar Diseases', 'Alcoholism-cause-Cerebellar Ataxia', 'Myelodysplastic Syndromes-defined-Hematologic Diseases', 'Myelodysplastic Syndromes-defined-Dysplastic Nevus Syndrome', 'Aging, Premature-caused-Werner Syndrome', 'Dysplastic Nevus Syndrome-defined-Myelodysplastic Syndromes', 'Stroke-associate-Dementia', 'Dementia-associate-Stroke', 'Death-assessed-Lupus Erythematosus, Systemic', 'Aortic Valve Stenosis-stratify-Ventricular Dysfunction', 'Cardiovascular Diseases-contribute-Myocardial Infarction', 'Muscular Dystrophy, Duchenne-defined-Bone Diseases, Metabolic', 'Muscular Dystrophy, Duchenne-defined-Osteoporosis', 'Atrial Fibrillation-detect-Stroke', 'Atrial Fibrillation-represent-Stroke', 'Arrhythmias, Cardiac-represent-Stroke', 'Atrial Fibrillation-bear-Stroke', 'Breast Neoplasms-suffer-Arthralgia', 'Sarcopenia-highlighted-Inflammation', 'Sarcopenia-highlighted-Acidosis', 'Renal Insufficiency-highlighted-Inflammation', 'Renal Insufficiency-highlighted-Acidosis', 'Sarcopenia-include-Acidosis', 'Renal Insufficiency, Chronic-include-Acidosis', 'Idiopathic Pulmonary Fibrosis-identified-Malocclusion', 'Xerostomia-rely-Dehydration', 'Metabolic Syndrome-experience-Prostatic Hyperplasia', 'Cardiomyopathy, Dilated-found-Venous Thrombosis', 'Venous Thrombosis-include-Cardiomyopathy, Dilated', 'Venous Thrombosis-exhibit-Thrombosis', 'Hepatitis B, Chronic-result-Hepatitis', 'Hepatitis B, Chronic-result-Fibrosis', 'Hepatitis B, Chronic-result-Carcinoma, Hepatocellular', 'Chemical and Drug Induced Liver Injury-become-Hepatitis B', 'Hepatitis-result-Fibrosis', 'Hepatitis-result-Carcinoma, Hepatocellular', 'Latent Tuberculosis-investigate-Renal Insufficiency, Chronic', 'Death-record-Dementia', 'Death-increase-Myotonic Dystrophy', 'Fractures, Bone-compare-Osteoporotic Fractures', 'Drug-Related Side Effects and Adverse Reactions-pursue-Erectile Dysfunction', 'Basal Ganglia Cerebrovascular Disease-underlie-Erectile Dysfunction', 'Dementia-considered-Hearing Loss', 'Arthritis-occur-Diabetes Mellitus', 'Arthritis-occur-Neoplasms', 'Sarcopenia-coexist-Obesity', 'Sarcopenia-linked-Osteoporosis', 'Hip Fractures-affect-Osteoporotic Fractures', 'Sarcopenia-suffer-Osteoporotic Fractures', 'Gastrointestinal Hemorrhage-increase-Atrial Fibrillation', 'Puberty, Delayed-develop-Poisoning', 'Hemorrhage-occur-Atrial Fibrillation', 'Motor Neuron Disease-develop-Poisoning', 'Poisoning-develop-Organophosphate Poisoning', 'Muscular Atrophy-predispose-Death', 'Sarcopenia-predispose-Death', 'Wounds and Injuries-include-Fractures, Bone', 'Peripheral Arterial Disease-grouped-Atherosclerosis', 'Peripheral Arterial Disease-grouped-Death', 'Peripheral Arterial Disease-associated-Cerebrovascular Disorders', 'Cerebrovascular Disorders-associated-Peripheral Arterial Disease', 'Infections-follow-Esophageal Neoplasms', 'Heart Failure-use-Death', 'Cardiovascular Diseases-quantify-Cardiomyopathy, Hypertrophic', 'Cardiovascular Diseases-quantify-Hypotension', 'Obesity-confirm-Infections', 'Peripheral Vascular Diseases-confirm-Infections', 'Infections-identify-Stroke', 'Diabetes Mellitus-followed-Foot Ulcer', 'Hypotension-observed-Optic Neuropathy, Ischemic', 'Inflammation-include-Polymyalgia Rheumatica', 'Inflammation-include-Arteritis', 'Inflammation-include-Pulmonary Disease, Chronic Obstructive', 'Fatigue-alleviate-Breast Neoplasms', 'Lymphoma, B-Cell-occur-Immunologic Deficiency Syndromes', 'Leukoencephalopathies-refer-Aneurysm', 'Infarction-refer-Aneurysm', 'Endocrine System Diseases-affect-Fabry Disease', 'Obesity-analysed-Hypertension', 'Vascular Remodeling-include-Hypertension', 'Inflammation-include-Hypertension', 'Calcinosis-include-Hypertension', 'Hypertension-accelerate-Vascular Remodeling', 'Hypertension-accelerate-Aneurysm', 'Death-related-Lung Diseases', 'Alzheimer Disease-prevent-Delirium', 'Acute Coronary Syndrome-include-Death', 'Syncope-occur-Heart Failure', 'Peripheral Vascular Diseases-associated-Death', 'Death-associated-Peripheral Vascular Diseases', 'Paraganglioma-present-Vertigo', 'Coronary Artery Disease-classified-Acute Coronary Syndrome', 'Dementia-accepted-Delirium', 'Thrombocytosis-assess-Venous Thrombosis', 'Inflammation-accelerate-Dementia', 'Neoplasms-associated-Polyploidy', 'Polyploidy-associated-Neoplasms', 'Sarcopenia-assessed-Obesity, Abdominal', 'Anemia-evaluated-Malnutrition', 'Anemia-evaluated-Hypoalbuminemia', 'Inflammation-play-Heart Failure', 'Inflammation-result-Hyperplasia', 'Heart Failure-cause-Muscle Weakness', 'Atrioventricular Block-constitute-Heart Diseases', 'Obesity-recruited-Weight Loss', 'Osteoarthritis-include-Bone Marrow Diseases', 'Osteoarthritis-involve-Bone Marrow Diseases', 'Osteoarthritis-include-Inflammation', 'Bone Marrow Diseases-associated-Pain', 'Pain-associated-Bone Marrow Diseases', 'Bone Marrow Diseases-associated-Osteoarthritis', 'Osteoarthritis-associated-Bone Marrow Diseases', 'Hypertension-considered-Renal Insufficiency', 'Hypertension-considered-Kidney Failure, Chronic', 'Nephrosclerosis-ascribed-Hypertension', 'Nephrosclerosis-classify-Renal Insufficiency', 'Kidney Diseases-complicated-Hypertension', 'Kidney Diseases-neglect-Kidney Failure, Chronic', 'Hypertension-complicated-Kidney Failure, Chronic', 'Obesity-considered-Nephrosclerosis', 'Dyslipidemias-considered-Nephrosclerosis', 'Kidney Diseases-comprise-Ischemia', 'Hyponatremia-use-Polyuria', 'Death-encounter-Dementia', 'Death-expected-Dementia', 'Coronary Artery Disease-occur-Aortic Valve Stenosis', 'Carotid Artery Diseases-include-Cardiovascular Diseases', 'Aortic Aneurysm-include-Cardiovascular Diseases', 'Alzheimer Disease-correlated-Atrophy', 'Pain-used-Osteoarthritis', 'Death-provide-Neoplasms', 'Headache Disorders, Secondary-account-Memory Disorders', 'Deglutition Disorders-eliminate-Fistula', 'Deglutition Disorders-eliminate-Chest Pain', 'Fistula-eliminate-Chest Pain', 'Neurodegenerative Diseases-become-Dementia', 'Hip Fractures-malnourished-Malnutrition', 'Parkinson Disease-report-Neurologic Manifestations', 'Heart Failure-result-Death', 'Neoplasms-type-Diabetes Mellitus', 'Kidney Diseases-affect-Hypertension', 'Cardiomyopathies-range-Heart Failure', 'Heart Failure-range-Cardiomyopathies', 'Alzheimer Disease-occur-Death', 'Diabetes Mellitus-prevent-Pneumonia', 'Diabetes Mellitus-prevent-Death', 'Death-caused-Heart Arrest', 'Pulmonary Disease, Chronic Obstructive-combined-Atrial Fibrillation', 'Pulmonary Disease, Chronic Obstructive-combined-Renal Insufficiency', 'Pulmonary Disease, Chronic Obstructive-combined-Diabetes Mellitus', 'Heart Failure-combined-Atrial Fibrillation', 'Heart Failure-combined-Renal Insufficiency', 'Heart Failure-combined-Diabetes Mellitus', 'Death-found-Dementia', 'Death-found-Nervous System Diseases', 'Obesity-undergo-Neoplasms', 'Neoplasms-undergo-Infections', 'Inflammation-considered-Cachexia', 'Inflammation-considered-Basal Ganglia Cerebrovascular Disease', 'Inflammation-considered-Sleep Initiation and Maintenance Disorders', 'Inflammation-considered-Death', 'Cachexia-considered-Sleep Initiation and Maintenance Disorders', 'Cachexia-considered-Death', 'Basal Ganglia Cerebrovascular Disease-considered-Sleep Initiation and Maintenance Disorders', 'Basal Ganglia Cerebrovascular Disease-considered-Death', 'Inflammation-arisen-Uremia', 'Urticaria-associated-Neoplastic Syndromes, Hereditary', 'Neoplastic Syndromes, Hereditary-associated-Urticaria', 'Respiratory Tract Diseases-result-Respiratory Insufficiency', 'Fatty Liver-include-Liver Diseases', 'Liver Diseases, Alcoholic-include-Liver Diseases', 'Osteoporosis-occur-Wounds and Injuries', 'Hyperlipidemias-include-Stroke', 'Neoplasms-seen-Immunologic Deficiency Syndromes', 'Cardiovascular Abnormalities-increase-Cardiovascular Diseases', 'Hematuria-diagnosed-Urinary Bladder Neoplasms', 'Cardiovascular Abnormalities-increase-Diabetes Mellitus, Type 2', 'Death-model-Heart Failure', 'Adenomatous Polyposis Coli-excluded-Kidney Diseases', 'Sleep Wake Disorders-precede-Dementia', 'Adenomatous Polyposis Coli-excluded-Urologic Neoplasms', 'Aneuploidy-increase-Infertility, Female', 'Death-increase-Nervous System Diseases', 'Fragile X Syndrome-cause-Fractures, Bone', 'Neoplasms-reveal-Breast Neoplasms', 'Hyperhomocysteinemia-associated-Ischemia', 'Ischemia-associated-Hyperhomocysteinemia', 'Stroke-consider-Coronary Artery Disease', 'Stroke-consider-Moyamoya Disease', 'Multiple Organ Failure-speak-Death', 'Respiratory Tract Infections-account-Death', 'Peripheral Nervous System Diseases-include-Gastroesophageal Reflux', 'Infections-include-Gastroesophageal Reflux', 'Hypoglycemia-increase-Hip Fractures', 'Heart Failure, Systolic-review-Hypotension, Orthostatic', 'Wounds and Injuries-play-Inflammation', 'Skin Diseases-result-Prostatic Neoplasms', 'Nerve Degeneration-precede-Death', 'Glaucoma-precede-Death', 'Atherosclerosis-involved-Calcinosis', 'Heart Valve Diseases-prevent-Aortic Valve Stenosis', 'Renal Insufficiency, Chronic-defined-Urinary Bladder Diseases', 'Renal Insufficiency, Chronic-based-Proteinuria', 'Renal Insufficiency, Chronic-based-Kidney Diseases', 'Renal Insufficiency, Chronic-concern-Kidney Diseases', 'Renal Insufficiency, Chronic-identify-Renal Insufficiency', 'Inflammation-enhance-Metabolic Syndrome', 'Chronic Disease-affect-Obesity, Abdominal', 'Chronic Disease-affect-Metabolic Syndrome', 'Chronic Disease-affect-Diabetes Mellitus', 'Chronic Disease-affect-Atherosclerosis', 'Chronic Disease-affect-Hypertension', 'Chronic Disease-affect-Dementia', 'Hypertension-comprise-Atherosclerosis', 'Hypertension-comprise-Cardiovascular Diseases', 'Cholecystitis-considered-Hip Fractures', 'Hip Fractures-develop-Cholecystitis, Acute', 'Hip Fractures-cause-Cholecystitis, Acute', 'Inflammation-contribute-Calcinosis', 'Drug Hypersensitivity-compare-Gastroesophageal Reflux', 'Asthma-compare-Gastroesophageal Reflux', 'Diabetes Mellitus-take-Lipid Metabolism Disorders', 'Deglutition Disorders-cause-Sarcopenia', 'Stroke-cause-Deglutition Disorders', 'Muscular Atrophy-associate-Death', 'Death-associate-Muscular Atrophy', 'Muscular Atrophy-associate-Renal Insufficiency, Chronic', 'Renal Insufficiency, Chronic-associate-Muscular Atrophy', 'Cachexia-associate-Death', 'Death-associate-Cachexia', 'Cachexia-associate-Renal Insufficiency, Chronic', 'Renal Insufficiency, Chronic-associate-Cachexia', 'Obesity-attenuated-Renal Insufficiency, Chronic', 'Heart Diseases-associated-Tooth Loss', 'Tooth Loss-associated-Heart Diseases', 'Hypertension-associated-Tooth Loss', 'Tooth Loss-associated-Hypertension', 'Diabetes Mellitus-associated-Tooth Loss', 'Tooth Loss-associated-Diabetes Mellitus', 'Tooth Loss-associated-Dementia', 'Dementia-associated-Tooth Loss', 'Leukoencephalopathies-associated-Leukoaraiosis', 'Leukoaraiosis-associated-Leukoencephalopathies', 'Neoplasms-promote-Death', 'Lung Diseases-found-Pulmonary Disease, Chronic Obstructive', 'Myocardial Infarction-receive-Stroke', 'Cardiovascular Diseases-observed-Death', 'Cardiovascular Diseases-observed-Myocardial Infarction', 'Cardiovascular Diseases-observed-Stroke', 'Infarction-driven-Intracranial Arteriosclerosis', 'Infarction-driven-Arteriolosclerosis', 'Cerebellar Diseases-influenced-Ataxia', 'Hepatomegaly-suggest-Parkinson Disease', 'Low Back Pain-worsen-Headache', 'Parkinson Disease-considered-Back Pain', 'Leukoaraiosis-showed-Death', 'Leukoaraiosis-characterized-Hereditary Central Nervous System Demyelinating Diseases', 'Leukoaraiosis-characterized-Demyelinating Diseases', 'Hypothyroidism-include-Endocrine System Diseases', 'Diabetes Mellitus-include-Endocrine System Diseases', 'Acute Coronary Syndrome-justify-Chest Pain', 'Death-receive-Heart Failure', 'Heart Failure-estimate-Death', 'Movement Disorders-slow-Neurodegenerative Diseases', 'Sleep Wake Disorders-witness-Apnea', 'Movement Disorders-rescue-Death', 'Neurodegenerative Diseases-rescue-Death', 'Hyperkinesis-play-Alzheimer Disease', 'Liver Failure-represent-Fibrosis', 'Diabetes Mellitus-contribute-Non-alcoholic Fatty Liver Disease', 'Cataract-related-Alzheimer Disease', 'Cataract-provide-Alzheimer Disease', 'Sclerosis-lead-Neurodegenerative Diseases', 'Neurodegenerative Diseases-drive-Multiple Sclerosis', 'Neurodegenerative Diseases-include-Mitochondrial Diseases', 'Neoplasms-prescribed-Deglutition Disorders', 'Neoplasms-prescribed-Intestinal Diseases', 'Sarcopenia-identified-Drug-Related Side Effects and Adverse Reactions', 'Weight Loss-identified-Drug-Related Side Effects and Adverse Reactions', 'Neoplasms-caused-Head and Neck Neoplasms', 'Anorexia-caused-Head and Neck Neoplasms', 'Syncope-suffer-Unconsciousness', 'Hypertension-emerge-Death', 'Hypertension-emerge-Cardiovascular Diseases', 'Death-emerge-Cardiovascular Diseases', 'Death-predict-Atrial Fibrillation', 'Fractures, Bone-result-Oculocerebrorenal Syndrome', 'Movement Disorders-develop-Stroke', 'Movement Disorders-develop-Diabetes Mellitus', 'Movement Disorders-develop-Neoplasms', 'Movement Disorders-develop-Infections', 'Movement Disorders-develop-Hepatolenticular Degeneration', 'Movement Disorders-develop-Thyrotoxicosis', 'Dyskinesias-associated-Hyperglycemia', 'Hyperglycemia-associated-Dyskinesias', 'Prostatitis-create-Atherosclerosis', 'Prostatitis-result-Carcinoma', 'Prostatitis-result-Smooth Muscle Tumor', 'Prostatitis-result-Fibrosis', 'Dementia-caused-Brain Damage, Chronic', 'Heart Arrest-result-Pneumonia', 'Tachycardia-prevent-Cardiovascular Diseases', 'Cardiovascular Diseases-prevent-Hypotension', 'Hypertension-modify-Cardiovascular Diseases', 'Cardiovascular Diseases-prevent-Hyperkalemia', 'Hypertension-prevent-Heart Diseases', 'Malnutrition-identified-Death', 'Inflammation-identified-Death', 'Sarcopenia-attributed-Atrophy', 'Colorectal Neoplasms-develop-Polyps', 'Colorectal Neoplasms-develop-Adenoma', 'Neoplasms-develop-Polyps', 'Neoplasms-develop-Adenoma', 'Atrial Fibrillation-receive-Thromboembolism', 'Muscular Disorders, Atrophic-associated-Xerostomia', 'Xerostomia-associated-Muscular Disorders, Atrophic', 'Candidiasis, Oral-identify-Stomatitis', 'Candidiasis, Oral-identify-Tongue Diseases', 'Candidiasis, Oral-identify-Glossitis', 'Tongue Diseases-identify-Stomatitis', 'Glossitis-identify-Stomatitis', 'Infections-live-Chronic Disease', 'Hematologic Neoplasms-range-Hodgkin Disease', 'Heart Failure-dilate-Cardiomyopathy, Dilated', 'Cardiomyopathy, Dilated-linked-Ventricular Dysfunction', 'Uterine Cervical Neoplasms-targeted-Neoplasms', 'Cardiomyopathy, Dilated-progress-Heart Failure', 'Arbovirus Infections-lead-Neoplasms', 'Infections-lead-Neoplasms', 'Anemia-associated-Mitochondrial Diseases', 'Mitochondrial Diseases-associated-Anemia', 'Pain-measure-Pain Insensitivity, Congenital', 'Spinal Cord Injuries-result-Fractures, Bone', 'Contracture-combined-Fractures, Bone', 'Pain-cause-Muscle Weakness', 'Mucositis-include-Gastroesophageal Reflux', 'Sepsis-progress-Shock, Septic', 'Sepsis-include-Pulmonary Disease, Chronic Obstructive', 'Infections-undergo-Dyspepsia', 'Peptic Ulcer-undergo-Dyspepsia', 'Stomach Diseases-undergo-Dyspepsia', 'Multiple Myeloma-influenced-Drug-Related Side Effects and Adverse Reactions', 'Hypertension-consider-Diabetes Mellitus', 'Hypertension-gain-Diabetes Mellitus', 'Hypertension-gain-Cardiovascular Diseases', 'Diabetes Mellitus-gain-Cardiovascular Diseases', 'Hypothalamic Neoplasms-include-Alzheimer Disease', 'Hypospadias-contribute-Hypogonadism', 'Hypogonadism-increase-Osteoporosis', 'Cryptorchidism-contribute-Hypogonadism', 'Hypogonadism-associated-Metabolic Syndrome', 'Metabolic Syndrome-associated-Hypogonadism', 'Subarachnoid Hemorrhage-associated-Cerebral Amyloid Angiopathy', 'Cerebral Amyloid Angiopathy-associated-Subarachnoid Hemorrhage', 'Sarcopenia-refine-Fractures, Bone', 'Aneuploidy-tend-Neoplasms', 'Aneuploidy-develop-Neoplasms', 'Death-reduce-Renal Insufficiency, Chronic', 'Death-seen-Wounds and Injuries', 'Kidney Failure, Chronic-associate-Stroke', 'Stroke-associate-Kidney Failure, Chronic', 'Hearing Loss-seem-Hearing Disorders', 'Helicobacter Infections-acquire-Stomach Diseases', 'Gastritis-caused-Infections', 'Gastritis-observed-Stomach Diseases', 'Infections-observed-Stomach Diseases', 'Critical Illness-lead-Heart Arrest', 'Alzheimer Disease-include-Headache Disorders, Secondary', 'Psychomotor Agitation-include-Headache Disorders, Secondary', 'Sleep Wake Disorders-include-Headache Disorders, Secondary', 'Sleep Wake Disorders-develop-Dementia', 'Hypotension-associated-Infarction', 'Infarction-associated-Hypotension', 'Hypotension-associated-Headache Disorders, Secondary', 'Headache Disorders, Secondary-associated-Hypotension', 'Hypotension-associated-Stroke', 'Stroke-associated-Hypotension', 'Constriction, Pathologic-referred-Syncope', 'Stroke-derived-Syncope', 'Lupus Erythematosus, Systemic-contribute-Death', 'Diabetes Mellitus-reported-Coronary Artery Disease', 'Short Bowel Syndrome-caused-Hernia, Femoral', 'Pulmonary Disease, Chronic Obstructive-classify-Lung Diseases, Obstructive', 'Urinary Incontinence-mentioned-Ulcer', 'Trachoma-eliminated-Infections', 'Immune System Diseases-describe-Primary Ovarian Insufficiency', 'Seizures-linked-Neoplasms', 'Amenorrhea-predicted-Primary Ovarian Insufficiency', 'Cardiovascular Diseases-increase-Neoplasms', 'Seizures-stand-Neoplasms, Multiple Primary', 'Death-followed-Aneurysm', 'Death-followed-Chemical and Drug Induced Liver Injury', 'Death-improve-Wounds and Injuries', 'Pharyngeal Diseases-present-Erythema', 'Pain-make-Dementia', 'Erythema-correspond-Psoriasis', 'Pain-unaffected-Dementia', 'Chemical and Drug Induced Liver Injury-resemble-Fibrosis', 'Hepatolenticular Degeneration-correlated-Chemical and Drug Induced Liver Injury', 'Pain-include-Candidiasis, Oral', 'Dysgeusia-include-Candidiasis, Oral', 'Anemia-compare-Death', 'Diverticulum-determine-Diverticulitis', 'Intellectual Disability-compared-Aortic Aneurysm, Abdominal', 'Intellectual Disability-treated-Aortic Aneurysm, Abdominal', 'Intellectual Disability-reduced-Aortic Aneurysm, Abdominal', 'Hypertension-treat-Hypogonadism', 'Atrial Fibrillation-compare-Embolism', 'Stroke-compare-Embolism', 'Diabetes Mellitus-minimize-Hyperglycemia', 'Diabetes Mellitus-minimize-Hypoglycemia', 'Hypoglycemia-include-Hyperglycemia', 'Heart Failure, Diastolic-increase-Cardiovascular Diseases', 'Heart Failure, Diastolic-increase-Death', 'Osteoporotic Fractures-lead-Death', 'Amnesia-observed-Fractures, Bone', 'Amnesia-suffer-Osteoporotic Fractures', 'Osteoporotic Fractures-undergo-Fractures, Bone', 'Osteoporotic Fractures-suffer-Fractures, Bone', 'Amnesia-sustain-Osteoporotic Fractures', 'Hematoma-aimed-Blood Coagulation Disorders', 'Hemorrhage-aimed-Blood Coagulation Disorders', 'Death-vary-Heart Diseases', 'Coronary Artery Disease-modeled-Cardiovascular Diseases', 'Coronary Artery Disease-stratified-Cardiovascular Diseases', 'Cardiovascular Diseases-observed-Coronary Artery Disease', 'Hypertension-present-Myocardial Infarction', 'Hypertension-present-Stroke', 'Death-identified-Dementia', 'Alzheimer Disease-viewed-Neurodegenerative Diseases', 'Breast Neoplasms-linked-Neoplasms', 'Brain Injuries-associated-Alzheimer Disease', 'Alzheimer Disease-associated-Brain Injuries', 'Alzheimer Disease-tested-Diabetes Mellitus', 'Alzheimer Disease-tested-Hypertension', 'Alzheimer Disease-tested-Dyslipidemias', 'Diabetes Mellitus, Type 2-associated-End Stage Liver Disease', 'End Stage Liver Disease-associated-Diabetes Mellitus, Type 2', 'Obesity, Abdominal-show-Muscle Weakness', 'Shock-induce-Inflammation', 'Osteosarcoma-counteract-Bone Neoplasms', 'Bone Neoplasms-reverse-Osteoporosis', 'Drug Hypersensitivity-identify-Rhinitis, Allergic', 'Stroke-expose-Hemorrhage', 'Embolism-expose-Hemorrhage', 'Rhinitis, Allergic-admitted-Drug Hypersensitivity', 'Heart Failure-decrease-Stroke', 'Heart Failure-decrease-Kidney Diseases', 'Myocardial Infarction-decrease-Stroke', 'Myocardial Infarction-decrease-Kidney Diseases', 'Stroke-decrease-Kidney Diseases', 'Spondylosis-cause-Nervous System Diseases', 'Uterine Cervicitis-cause-Nervous System Diseases', 'Spinal Cord Injuries-recover-Head and Neck Neoplasms', 'Head and Neck Neoplasms-put-Spondylosis', 'Head and Neck Neoplasms-put-Spinal Cord Injuries', 'Neuralgia-used-Nervous System Diseases', 'Neuralgia-access-Nervous System Diseases', 'Gastric Outlet Obstruction-caused-Gallstones', 'Sleep Wake Disorders-manage-Sleep Apnea, Obstructive', 'Calcinosis-promote-Cerebrovascular Disorders', 'Calcinosis-promote-Atherosclerosis', 'Calcinosis-expressed-Progeria', 'Cerebrovascular Disorders-seen-Progeria', 'Atherosclerosis-seen-Progeria', 'Hypertension-cause-Leukoencephalopathies', 'Hypertension-cause-Dementia', 'Hyperlipidemias-cause-Leukoencephalopathies', 'Hyperlipidemias-cause-Dementia', 'Diabetes Mellitus-cause-Leukoencephalopathies', 'Diabetes Mellitus-cause-Dementia', 'Leukoencephalopathies-contribute-Dementia', 'Cerebrovascular Disorders-confounded-Dementia', 'Obesity-reveal-Cholestasis', 'Lordosis-generate-Pseudarthrosis', 'Lordosis-generate-Kyphosis', 'Lordosis-generate-Pain', 'Death, Sudden-identify-Ischemia', 'Ischemia-identify-Coronary Artery Disease', 'Heart Failure-hospitalize-Diabetes Mellitus', 'Death-evaluate-Coronary Artery Disease', 'Myocardial Infarction-increasing-Death', 'Pneumonia-continue-Death', 'Hypoalbuminemia-increase-Pneumonia', 'Death-describe-Neoplasms', 'Inflammation-link-Infections', 'Inflammation-link-HIV Infections', 'Obesity-isolate-Hypertension', 'Diabetes Mellitus-isolate-Hypertension', 'Diabetes Mellitus-constitute-Obesity', 'Alzheimer Disease-describe-Osteoporosis', 'Diabetes Mellitus-experience-Death', 'Cerebral Infarction-follow-Thrombosis', 'Cerebral Infarction-account-Cerebrovascular Disorders', 'Thrombosis-account-Cerebrovascular Disorders', 'Embolism-account-Cerebrovascular Disorders', 'Myasthenia Gravis-characterized-Fatigue', 'Myasthenia Gravis-confused-Cerebrovascular Disorders', 'Myasthenic Syndromes, Congenital-characterized-Dysarthria', 'Dysarthria-considered-Myasthenia Gravis', 'Fractures, Bone-associated-Chronic Disease', 'Chronic Disease-associated-Fractures, Bone', 'Papillomavirus Infections-associated-Neoplasms', 'Neoplasms-associated-Papillomavirus Infections', 'Papillomavirus Infections-associated-Vulvar Neoplasms', 'Vulvar Neoplasms-associated-Papillomavirus Infections', 'Neoplasms-increased-Death', 'Death-increased-Ovarian Neoplasms', 'Myocarditis-known-Cardiomyopathies', 'Communicable Diseases-increase-Infections', 'Communicable Diseases-occur-Infections', 'Heart Failure-caused-Myocarditis', 'Paraneoplastic Syndromes-characterised-Neoplasms', 'Fibrosarcoma-characterised-Neoplasms', 'Neoplasms-cause-Communicable Diseases', 'Lung Diseases, Obstructive-diagnose-Signs and Symptoms, Respiratory', 'Lung Diseases, Obstructive-rule-Airway Obstruction', 'Lung Diseases, Obstructive-rule-Signs and Symptoms, Respiratory', 'Airway Obstruction-caused-Heart Failure', 'Airway Obstruction-confirm-Lung Neoplasms', 'Signs and Symptoms, Respiratory-caused-Heart Failure', 'Signs and Symptoms, Respiratory-caused-Lung Neoplasms', 'Hypertriglyceridemia-associate-Pancreatitis', 'Pancreatitis-associate-Hypertriglyceridemia', 'Hypertriglyceridemia-associate-Adenoma', 'Adenoma-associate-Hypertriglyceridemia', 'Carbohydrate Metabolism, Inborn Errors-justified-Cardiovascular Diseases', 'Metabolic Syndrome-justified-Cardiovascular Diseases', 'Renal Insufficiency, Chronic-warranted-Metabolic Syndrome', 'Metabolic Syndrome-prevent-Renal Insufficiency, Chronic', 'Cushing Syndrome-enhance-Hyperparathyroidism, Primary', 'Osteoarthritis-considered-Cardiovascular Diseases', 'Biliary Tract Diseases-lead-Cholecystitis', 'Arrhythmias, Cardiac-include-Renal Insufficiency', 'Arrhythmias, Cardiac-include-Respiratory Tract Infections', 'Arrhythmias, Cardiac-include-Stroke', 'Neoplasm Invasiveness-result-Death', 'Death-predicted-Coronary Artery Disease', 'Death-predicted-Neoplasms', 'Alzheimer Disease-estimated-Hypertension', 'Skin Neoplasms-confirm-Neoplasms', 'Skin Neoplasms-confirm-Carcinoma, Squamous Cell', "Skin Neoplasms-confirm-Hutchinson's Melanotic Freckle", 'Brain Injuries, Traumatic-produce-Atrophy', 'Hypertension-avoid-Hypotension, Orthostatic', 'Death-assessed-Fractures, Bone', 'Myalgia-associated-Mitochondrial Diseases', 'Mitochondrial Diseases-associated-Myalgia', 'Diabetes Mellitus, Type 2-associated-Muscle Weakness', 'Muscle Weakness-associated-Diabetes Mellitus, Type 2', 'Diabetes Mellitus, Type 2-lead-Muscle Weakness', 'Hereditary Breast and Ovarian Cancer Syndrome-result-Death', 'Vision Disorders-increase-Death', 'Hypertension-increase-Sleep Wake Disorders', 'Death-reduced-Hypertension', 'Atherosclerosis-related-Osteoporosis', 'Inflammation-related-Osteoporosis', 'Pseudomonas Infections-exposed-Wounds and Injuries', 'Mitochondrial Diseases-play-Osteoarthritis', 'Congenital Hyperinsulinism-compare-Diabetes Mellitus, Type 2', 'Proteinuria-associated-Infections', 'Infections-associated-Proteinuria', 'Vision Disorders-identified-Blindness', 'Vision Disorders-recorded-Blindness', 'Communicable Diseases-prepared-Cardiovascular Diseases', 'Communicable Diseases-prepared-Diabetes Mellitus', 'Communicable Diseases-prepared-Neoplasms', 'Communicable Diseases-prepared-Respiratory Tract Diseases', 'Atrial Fibrillation-identified-Chediak-Higashi Syndrome', 'Diabetes Mellitus-exhibit-Hip Fractures', 'Puberty, Delayed-characterized-Paralysis', 'Motor Neuron Disease-characterized-Paralysis', 'Hyperglycemia-impair-Obesity', 'Alzheimer Disease-undergo-Atrophy', 'Chemical and Drug Induced Liver Injury-treat-Tuberculosis', 'Renal Insufficiency, Chronic-associated-Communicable Diseases', 'Communicable Diseases-associated-Renal Insufficiency, Chronic', 'Coma-collected-Brain Injuries, Traumatic', 'Melanoma-recognize-Skin Diseases', 'Neoplasms-include-Sexual Dysfunction, Physiological', 'Cardiovascular Diseases-regarded-Atherosclerosis', 'Cardiovascular Diseases-regard-Cerebrovascular Disorders', 'Deglutition Disorders-used-Airway Obstruction', 'Deglutition Disorders-describe-Airway Obstruction', 'Neoplasms-associated-Gastroesophageal Reflux', 'Gastroesophageal Reflux-associated-Neoplasms', 'Esophageal Motility Disorders-associated-Gastroesophageal Reflux', 'Gastroesophageal Reflux-associated-Esophageal Motility Disorders', 'Neuromuscular Diseases-include-Oropharyngeal Neoplasms', 'Oropharyngeal Neoplasms-associated-Gastroesophageal Reflux', 'Gastroesophageal Reflux-associated-Oropharyngeal Neoplasms', 'Neuromuscular Diseases-associated-Gastroesophageal Reflux', 'Gastroesophageal Reflux-associated-Neuromuscular Diseases', 'Myocardial Infarction-use-Death', 'Alzheimer Disease-associate-Anemia', 'Anemia-associate-Alzheimer Disease', 'Dementia-report-Alzheimer Disease', 'Fibrosis-regulate-Hypertension', 'Fibrosis-regulate-Diabetes Mellitus', 'Neoplasms-prevent-Hemorrhage', 'Neoplasms-control-Ulcer', 'Infections-increase-Memory Disorders', 'Cardiovascular Diseases-assessed-Death', 'Atherosclerosis-exert-Heart Failure', 'Shy-Drager Syndrome-linked-Myotonia', 'Shy-Drager Syndrome-characterize-Myotonia', 'Shy-Drager Syndrome-linked-Muscle Weakness', 'Shy-Drager Syndrome-characterize-Muscle Weakness', 'Shy-Drager Syndrome-linked-Atrophy', 'Shy-Drager Syndrome-linked-Heart Diseases', 'Shy-Drager Syndrome-characterize-Heart Diseases', 'Shy-Drager Syndrome-linked-Cataract', 'Shy-Drager Syndrome-characterize-Cataract', 'Death-addressed-Hepatitis C', 'Hemorrhage-associated-Wounds and Injuries', 'Wounds and Injuries-associated-Hemorrhage', 'Hemorrhage-increase-Hypoxia', 'Hemorrhage-increase-Blood Coagulation Disorders', 'Hemorrhage-increase-Multiple Organ Failure', 'Wounds and Injuries-increase-Hypoxia', 'Wounds and Injuries-increase-Blood Coagulation Disorders', 'Wounds and Injuries-increase-Multiple Organ Failure', 'Scoliosis-measured-Kyphosis', 'Movement Disorders-measured-Kyphosis', 'Mandibular Nerve Injuries-experience-Hematoma', 'Obesity-correlated-Pain', 'Pain-lead-Obesity', 'Pain-investigate-Obesity', 'Stomach Neoplasms-assess-Gastritis', 'Stomach Neoplasms-assess-Ulcer', 'Neurodegenerative Diseases-surpass-Neoplasms', 'Parkinson Disease-surpass-Neoplasms', 'Neoplasms-surpass-Death', 'Colorectal Neoplasms-attributed-Obesity', 'Pulmonary Disease, Chronic Obstructive-characterized-Airway Obstruction', 'Pulmonary Disease, Chronic Obstructive-characterized-Bronchiolitis', 'Pulmonary Disease, Chronic Obstructive-include-Emphysema', 'Pulmonary Disease, Chronic Obstructive-characterized-Dyspnea', 'Bronchiolitis-include-Airway Obstruction', 'Emphysema-include-Airway Obstruction', 'Dyspnea-include-Airway Obstruction', 'Urogenital Abnormalities-predispose-Cardiovascular Diseases', 'Diabetes Mellitus-develop-Kidney Diseases', 'Diabetes Mellitus-develop-Denys-Drash Syndrome', 'Sexual Dysfunction, Physiological-predispose-Cardiovascular Diseases', 'Renal Insufficiency, Chronic-manage-Diabetes Mellitus', 'Renal Insufficiency, Chronic-prevent-Diabetes Mellitus', 'Heart Arrest-treat-Diabetic Nephropathies', 'Pulmonary Disease, Chronic Obstructive-recommend-Dyspnea', 'Lung Diseases-contribute-Dyspnea', 'Lung Diseases-contribute-Pulmonary Disease, Chronic Obstructive', 'Hypertension-compare-Erectile Dysfunction', 'Sexual Dysfunction, Physiological-associated-Hemophilia A', 'Hemophilia A-associated-Sexual Dysfunction, Physiological', 'Dyspnea-ameliorate-Pulmonary Disease, Chronic Obstructive', 'Cartilage Diseases-classified-Osteoarthritis', 'Leukemia, Myelogenous, Chronic, BCR-ABL Positive-reduce-Neoplasms', 'Stomach Neoplasms-present-Neoplasm Metastasis', 'Inflammation-accelerate-Neurodegenerative Diseases', 'Urinary Bladder, Overactive-result-Alzheimer Disease', 'Heart Diseases-attenuate-Myocardial Infarction', 'Neoplasms-inhibit-Heart Arrest', 'Nerve Degeneration-protect-Ischemia', 'Vision Disorders-induced-Ischemia', 'Anemia-cause-Malnutrition', 'Memory Disorders-targeted-Dementia', 'Lordosis-merit-Pain', 'Muscular Atrophy-occur-Sarcopenia', 'Muscular Atrophy-occur-Malnutrition', 'Muscular Atrophy-occur-Lung Diseases, Obstructive', 'Neoplasms-include-Leukemia, Myeloid', 'Muscular Atrophy-occur-Cachexia', 'Muscular Atrophy-occur-Diabetes Mellitus', 'Muscular Atrophy-occur-Renal Insufficiency', 'Muscular Atrophy-occur-Heart Failure', 'Muscular Atrophy-occur-Cushing Syndrome', 'Muscular Atrophy-occur-Sepsis', 'Muscular Atrophy-occur-Wounds and Injuries', 'Hypoalbuminemia-worsen-Cardiovascular Diseases', 'Aneurysm-share-Diabetes Mellitus', 'Aneurysm-share-Dyslipidemias', 'Aneurysm-share-Obesity', 'Aniridia-show-Dry Eye Syndromes', 'Aortic Valve Stenosis-associated-Coronary Artery Disease', 'Coronary Artery Disease-associated-Aortic Valve Stenosis', 'Sleep Initiation and Maintenance Disorders-live-Death', 'Heart Diseases-associated-Coronary Artery Disease', 'Coronary Artery Disease-associated-Heart Diseases', 'Heart Diseases-associated-Liver Diseases', 'Liver Diseases-associated-Heart Diseases', 'Heart Diseases-associated-Muscular Diseases', 'Muscular Diseases-associated-Heart Diseases', 'Heart Diseases-associated-Blood Coagulation Disorders', 'Blood Coagulation Disorders-associated-Heart Diseases', 'Weight Loss-come-Obesity', 'Obesity-carry-Death', 'Obesity-come-Weight Gain', 'Rupture-use-Pain', 'Lung Neoplasms-reduce-Reperfusion Injury', 'Drug-Related Side Effects and Adverse Reactions-experience-Weight Loss', 'Drug-Related Side Effects and Adverse Reactions-develop-Sepsis', 'Weight Loss-experience-Hematologic Diseases', 'Weight Loss-develop-Sepsis', 'Hematologic Diseases-develop-Sepsis', 'Neurodegenerative Diseases-produced-Brain Injuries, Traumatic', 'Alzheimer Disease-fall-Glucose Metabolism Disorders', 'Alzheimer Disease-prevent-Nerve Degeneration', 'Glucose Metabolism Disorders-prevent-Nerve Degeneration', 'Chronic Disease-increase-Sleep Initiation and Maintenance Disorders', 'Obesity-euthanized-Stroke', 'Stroke-euthanized-Alzheimer Disease', 'Hypotension-associated-Coronary Artery Disease', 'Coronary Artery Disease-associated-Hypotension', 'Ischemia-appear-Angina Pectoris', 'Arrhythmias, Cardiac-appear-Angina Pectoris', 'Coronary Artery Disease-appear-Angina Pectoris', 'Hypertension-control-Stroke', 'Stroke-include-Neoplasms', 'Gait Disorders, Neurologic-arise-Wounds and Injuries', 'Gait Disorders, Neurologic-arise-Fatigue', 'Drug-Related Side Effects and Adverse Reactions-use-Prostatic Neoplasms', 'Nephrotic Syndrome-followed-Acute Kidney Injury', 'Nephrotic Syndrome-followed-Glomerulonephritis', 'Glomerulonephritis-followed-Acute Kidney Injury', 'Death-reduce-Brain Injuries, Traumatic', 'Wounds and Injuries-reduce-Brain Injuries, Traumatic', 'Kidney Diseases-present-Nephrotic Syndrome', 'Vasculitis-followed-Glomerulonephritis', 'Kidney Diseases-followed-Amyloidosis', 'Nephrotic Syndrome-followed-Amyloidosis', 'Amyloidosis-followed-Kidney Diseases', 'Hypothalamic Neoplasms-transported-Hypothalamic Diseases', 'Cardiomyopathies-limit-Infarction', 'Cardiomyopathies-limit-Ischemia', 'Stomach Diseases-include-Chemical and Drug Induced Liver Injury', 'Hypoxia-include-Chemical and Drug Induced Liver Injury', 'Sarcopenia-noted-Gait Disorders, Neurologic', 'Osteoporosis-noted-Gait Disorders, Neurologic', 'Death-include-Pulmonary Embolism', 'Death-caused-Pulmonary Embolism', 'Renal Insufficiency, Chronic-contribute-Inflammation', 'Renal Insufficiency, Chronic-include-Diabetes Insipidus, Nephrogenic', 'Renal Insufficiency, Chronic-contribute-Diabetes Insipidus, Nephrogenic', 'Renal Insufficiency, Chronic-contribute-Acute Kidney Injury', 'Acute Kidney Injury-prevent-Renal Insufficiency, Chronic', 'Diabetes Insipidus, Nephrogenic-prevent-Renal Insufficiency, Chronic', 'Diabetes Mellitus-prevent-Renal Insufficiency, Chronic', 'Hypertension-prevent-Renal Insufficiency, Chronic', 'Epilepsy, Absence-associated-Hip Fractures', 'Hip Fractures-associated-Epilepsy, Absence', 'Kidney Neoplasms-report-Birt-Hogg-Dube Syndrome', 'Neoplasms-seem-Kidney Neoplasms', 'Aortic Aneurysm, Abdominal-performed-Aneurysm', 'Inflammation-preface-Rupture', 'Neoplasms-induced-Inflammation', 'Neurodegenerative Diseases-induced-Inflammation', 'Death-include-Dehydration', 'Nephritis, Hereditary-comprise-Kidney Diseases', 'Hematuria-present-Proteinuria', 'Cockayne Syndrome-consist-Disease Progression', 'Aging, Premature-consist-Disease Progression', 'Sleep Deprivation-associated-Gliosis', 'Gliosis-associated-Sleep Deprivation', 'Sleep Deprivation-associated-Nerve Degeneration', 'Nerve Degeneration-associated-Sleep Deprivation', 'Myotonic Dystrophy-vary-Diabetes Mellitus', 'Myotonic Dystrophy-vary-Erectile Dysfunction', 'Respiratory Insufficiency-contribute-Delirium', 'Death-treated-Necrosis', 'Dyslipidemias-estimated-Coronary Artery Disease', 'Pneumothorax-develop-Dementia', 'Necrosis-increase-Fatigue', 'Sleep Wake Disorders-increase-Metabolic Syndrome', 'Bone Diseases-observed-Chronic Kidney Disease-Mineral and Bone Disorder', 'Vascular Calcification-observed-Chronic Kidney Disease-Mineral and Bone Disorder', 'Vascular Calcification-increase-Death', 'Kidney Diseases-predict-Cardiovascular Diseases', 'Immunologic Deficiency Syndromes-stimulate-Cardiomyopathy, Hypertrophic', 'Immunologic Deficiency Syndromes-augment-Fibrosis', 'Cardiomyopathy, Hypertrophic-augment-Fibrosis', 'Cardiomyopathy, Hypertrophic-augment-Vascular Calcification', 'Status Epilepticus-carry-Death', 'Death-admitted-Cerebral Infarction', 'Death-admitted-Stroke', 'Atrial Fibrillation-present-Heart Failure', 'Atrial Fibrillation-present-Thromboembolism', 'Atrial Fibrillation-observed-Heart Diseases', 'Death-predict-HIV Infections', 'Neoplasms-stabilized-Death', 'Neoplasms-diagnosed-Melanoma', 'Acute Kidney Injury-classified-Kidney Tubular Necrosis, Acute', 'Acute Kidney Injury-classified-Nephritis, Interstitial', 'Acute Kidney Injury-classified-Kidney Cortex Necrosis', 'Pneumonia-result-Deglutition Disorders', 'Pulmonary Disease, Chronic Obstructive-result-Deglutition Disorders', 'Heredodegenerative Disorders, Nervous System-result-Deglutition Disorders', 'Deglutition Disorders-result-Heart Failure', 'Arrhythmias, Cardiac-develop-Heart Failure', 'Arrhythmias, Cardiac-reduce-Atrial Fibrillation', 'Hypoglycemia-make-Heart Diseases', 'Kidney Diseases-assist-Weight Loss', 'Weight Loss-occur-Neoplasms', 'Weight Loss-occur-Obesity', 'Metabolic Syndrome-determined-Vision Disorders', 'Hypogonadism-associated-Death', 'Death-associated-Hypogonadism', 'Atherosclerosis-include-Death', 'Atrophy-serve-Alzheimer Disease', 'Memory Disorders-serve-Alzheimer Disease', 'Death-compare-Diabetes Mellitus', 'Obesity-coupled-Musculoskeletal Diseases', 'Hip Fractures-focused-Osteoporosis', 'Hip Fractures-focused-Sarcopenia', 'Lymphoma-conduct-Central Nervous System Diseases', 'Hip Fractures-focused-Delirium', 'Hip Fractures-focused-Weight Loss', 'Obesity-treat-Malnutrition', 'Dermatitis-affect-Urinary Incontinence', 'Skin Diseases-affect-Urinary Incontinence', 'Hemorrhage-explained-Asthenia', 'Eye Diseases, Hereditary-comprise-Retinal Diseases', 'Pain-compound-Diabetic Neuropathies', 'Pain-compound-Fibromyalgia', 'Pain-compound-Neuralgia', 'Pain-compound-Arthralgia', 'Pain-compound-Arthritis', 'Fractures, Bone-defined-Malocclusion', 'Fractures, Multiple-associated-Dementia', 'Dementia-associated-Fractures, Multiple', 'Neoplasms-compared-Leiomyoma', 'Neoplasms-compared-Neurilemmoma', 'Neoplasms-compared-Glomus Tumor', 'Neoplasms-identified-Gastrointestinal Stromal Tumors', 'Esophageal Neoplasms-identified-Gastrointestinal Stromal Tumors', 'Hyperthyroidism-associated-Atrial Fibrillation', 'Atrial Fibrillation-associated-Hyperthyroidism', 'Cardiovascular Diseases-seem-Hypertension', 'Stroke-based-Thoracic Outlet Syndrome', 'Thoracic Outlet Syndrome-arise-Stroke', 'Parkinsonian Disorders-differentiate-Parkinson Disease, Secondary', 'Parkinson Disease-interfere-Basal Ganglia Diseases', 'Cardiovascular Diseases-arise-Communicable Diseases', 'Dementia-arise-Death', 'Neuroleptic Malignant Syndrome-investigate-Parkinson Disease', 'Stroke-arise-Death', 'Pulmonary Disease, Chronic Obstructive-arise-Death', 'Vision Disorders-arise-Death', 'Death-contribute-Dementia', 'Colorectal Neoplasms-presented-Arthritis, Infectious', 'Colorectal Neoplasms-presented-Graft Occlusion, Vascular', 'Spinal Cord Diseases-lead-Paralysis', 'Death-noted-Aortic Aneurysm, Abdominal', 'Infections-present-Radiculopathy', 'Infections-rescue-Spinal Cord Diseases', 'Infections-present-Paralysis', 'Radiculopathy-rescue-Spinal Cord Diseases', 'Neoplasms-disturbed-Inflammation', 'Neoplasms-disturbed-Ulcer', 'Neoplasms-disturbed-Wounds and Injuries', 'Leukoencephalopathies-characterized-Demyelinating Diseases', 'Leukoencephalopathies-characterized-Alcoholic Neuropathy', 'Leukoencephalopathies-attributed-Ischemia', 'Demyelinating Diseases-attributed-Ischemia', 'Alcoholic Neuropathy-attributed-Ischemia', 'Heart Diseases-associated-Sarcopenia', 'Sarcopenia-associated-Heart Diseases', 'Hyperlipidemias-associated-Sarcopenia', 'Sarcopenia-associated-Hyperlipidemias', 'Bone Neoplasms-expand-Wounds and Injuries', 'Hypertension-given-Myocardial Infarction', 'Myocardial Infarction-given-Stroke', 'Colorectal Neoplasms-treat-Adrenal Insufficiency', 'Fractures, Bone-select-Neoplasms', 'Infections-required-Sarcoma, Kaposi', 'Sarcoma, Kaposi-register-Neoplasms', 'Death-elevated-Liver Diseases', 'Nervous System Diseases-under-recognised-Pain', 'Dementia-under-recognised-Pain', 'Pain-reported-Dementia', 'Diabetes Mellitus-alter-Sleep Wake Disorders', 'Dementia-include-Hyperglycemia', 'Dementia-include-Microvascular Angina', 'Fractures, Avulsion-classified-Heel Spur', 'HIV Infections-release-Neurotoxicity Syndromes', 'Neurotoxicity Syndromes-release-Death', 'Spasm-play-Coronary Artery Disease', 'Atherosclerosis-play-Coronary Artery Disease', 'Fecal Incontinence-defined-Urinary Incontinence', 'Fecal Incontinence-lose-Urinary Incontinence', 'Coronary Vasospasm-differ-Atherosclerosis', 'Angina Pectoris, Variant-found-Diabetes Mellitus', 'Diabetes Mellitus-found-Atherosclerosis', 'Cardiac Output, High-occur-Communicable Diseases', 'Death-reduce-Angina Pectoris', 'Death-reduce-Coronary Artery Disease', 'Heart Failure-reduce-Angina Pectoris', 'Angina Pectoris-reduce-Coronary Artery Disease', 'Cardiomyopathy, Hypertrophic-inherit-Genetic Diseases, Inborn', 'Genetic Diseases, Inborn-inherit-Heart Diseases', 'Sensation Disorders-suffer-Blindness', 'Infections-contribute-Atherosclerosis', 'Infections-contribute-Cerebrovascular Disorders', 'Infections-increase-Cerebral Infarction', 'Memory Disorders-include-Aortic Diseases', 'Cockayne Syndrome-characterized-Neurodegenerative Diseases', 'Ventricular Fibrillation-compare-Bundle-Branch Block', 'Tachycardia, Ventricular-compared-Bundle-Branch Block', 'Ventricular Fibrillation-compare-Heart Failure', 'Ventricular Fibrillation-compared-Bundle-Branch Block', 'Death-use-Peripheral Arterial Disease', 'Kyphosis-investigate-Diabetes Mellitus', 'Pain-caused-Fractures, Stress', 'Carcinoma, Hepatocellular-regulate-Neoplasms', 'Hypothalamic Neoplasms-contribute-Alzheimer Disease', 'Brain Diseases-include-Tauopathies', 'Communicable Diseases-include-Tauopathies', 'Wounds and Injuries-include-Tauopathies', 'Communicable Diseases-include-Brain Diseases', 'Wounds and Injuries-include-Brain Diseases', 'Cerebral Amyloid Angiopathy-interact-Alzheimer Disease', 'Hemorrhage-examine-Atrial Fibrillation', 'Death-prevent-Communicable Diseases', 'Infections-observed-Pneumonia', 'Delirium-reduce-Dementia', 'Sleep Wake Disorders-decline-Alzheimer Disease', 'Brain Diseases-observed-Alzheimer Disease', 'Hematologic Diseases-study-Leukemia, Myeloid, Acute', 'Leukemia-study-Leukemia, Myeloid, Acute', 'Hemophilia A-assess-Cardiovascular Diseases', 'Infertility, Female-play-Mitochondrial Diseases', 'Embryo Loss-play-Mitochondrial Diseases', 'Dehydration-associated-Nephrolithiasis', 'Nephrolithiasis-associated-Dehydration', 'Chronic Disease-drive-Death', 'Aneurysm, False-induced-Wounds and Injuries', 'Atherosclerosis-seen-Aneurysm, False', 'Aneurysm, False-induce-Myoclonus', 'Atherosclerosis-seen-Wounds, Nonpenetrating', 'Aneurysm, False-seen-Wounds, Nonpenetrating', 'Aneurysm, False-lead-Hemorrhage', 'Aneurysm, False-lead-Edema', 'Aneurysm, False-cause-Thrombosis', 'Hemorrhage-lead-Aneurysm, False', 'Edema-lead-Aneurysm, False', 'Neutropenia-associated-Cross Infection', 'Cross Infection-associated-Neutropenia', 'Infections-associated-Cross Infection', 'Cross Infection-associated-Infections', 'Leukemia, Myeloid-control-Cross Infection', 'Leukemia, Myeloid, Acute-control-Cross Infection', 'Candidiasis, Vulvovaginal-differentiate-Infections', 'Onychomycosis-attributed-Infections', 'Hernia-diagnosed-Osteoarthritis, Hip', 'Hernia-performed-Osteoarthritis, Hip', 'Stroke-remain-Diabetes Mellitus', 'Venous Thromboembolism-followed-Respiratory Insufficiency', 'Alzheimer Disease-cause-Inflammation', 'Fragile X Syndrome-lead-Alzheimer Disease', 'Infections-cause-Heredodegenerative Disorders, Nervous System', 'Hypertension-associated-Metabolic Syndrome', 'Metabolic Syndrome-associated-Hypertension', 'Uremia-contribute-Kidney Failure, Chronic', 'Infections-reduce-Stomach Neoplasms', 'Death-use-Anemia', 'Death-delete-Neoplasms', 'Death-delete-Myocardial Infarction', 'Death-delete-Heart Failure', 'Thrombosis-warrant-Atherosclerosis', 'Urinary Incontinence-known-Tooth, Impacted', 'Urinary Incontinence-impact-Tooth, Impacted', 'Urinary Incontinence-identified-Fractures, Bone', 'Lymphoma-drive-Carcinogenesis', 'Neoplasm Metastasis-contribute-Graft vs Host Disease', 'Malnutrition-associated-Communicable Diseases', 'Communicable Diseases-associated-Malnutrition', 'Corneal Diseases-contribute-Blindness', 'Blindness-contribute-Corneal Diseases', 'Alzheimer Disease-involve-Neurodegenerative Diseases', 'Alzheimer Disease-drive-Neoplasms', 'Neurodegenerative Diseases-drive-Neoplasms', 'Alzheimer Disease-include-Neoplasms', 'Neoplasms-include-Alzheimer Disease', 'Inflammation-seem-Pulmonary Disease, Chronic Obstructive', 'Wounds and Injuries-include-Infections', 'Wounds and Injuries-caused-Postpartum Hemorrhage', 'Inflammation-aggravated-Sepsis', 'Death-lead-Postpartum Hemorrhage', 'Aging, Premature-characterized-Neoplasms', 'Sarcopenia-associated-Angina Pectoris', 'Angina Pectoris-associated-Sarcopenia', 'Sarcopenia-associated-Myocardial Infarction', 'Myocardial Infarction-associated-Sarcopenia', 'Cardiovascular Diseases-observed-Sarcopenia', 'Cardiovascular Diseases-observed-Angina Pectoris', 'Cerebrovascular Disorders-show-Alzheimer Disease', 'Cerebrovascular Disorders-show-Aneurysm', 'Infarction-influence-Cerebrovascular Disorders', 'Aneurysm-show-Infarction', 'Infarction-lowering-Dementia', 'Alzheimer Disease-influence-Cerebrovascular Disorders', 'Alzheimer Disease-lowering-Dementia', 'Cerebrovascular Disorders-lowering-Dementia', 'Metabolic Syndrome-represent-Neurodegenerative Diseases', 'Neoplasms-seen-Multiple Myeloma', 'Neoplasms-seen-Lymphoma, Non-Hodgkin', 'Neoplasms-seen-Prostatic Neoplasms', 'Neoplasms-seen-Colorectal Neoplasms', 'Hip Fractures-live-Dementia', 'Stroke-become-Death', 'Peripheral Arterial Disease-associated-Obesity', 'Obesity-associated-Peripheral Arterial Disease', 'Critical Illness-acquired-Infections', 'Sepsis-acquired-Infections', 'Osteoporotic Fractures-associated-Fractures, Bone', 'Fractures, Bone-associated-Osteoporotic Fractures', 'Wounds and Injuries-trigger-Fractures, Bone', 'Kidney Failure, Chronic-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-Kidney Failure, Chronic', 'Werner Syndrome-develop-Retinal Detachment', 'Arthritis, Rheumatoid-become-Inflammation', 'Myopia-show-Retinal Detachment', 'Delirium-dysregulated-Alzheimer Disease', 'Genetic Diseases, Inborn-account-Death', 'Mononeuropathies-compare-Nervous System Diseases', 'Hearing Loss-do-Vision Disorders', 'Death-verified-Tuberculosis', 'Death-verified-Lung Neoplasms', 'Death-verified-Pneumonia', 'Death-verified-Pulmonary Disease, Chronic Obstructive', 'Tuberculosis-verified-Lung Neoplasms', 'Tuberculosis-verified-Pneumonia', 'Tuberculosis-verified-Pulmonary Disease, Chronic Obstructive', 'Thyroid Diseases-used-Thyroiditis, Autoimmune', 'Thyroid Diseases-designate-Thyroiditis, Autoimmune', 'Thyroid Diseases-used-Hashimoto Disease', 'Thyroid Diseases-support-Hashimoto Disease', 'Thyroiditis, Autoimmune-used-Hashimoto Disease', 'Thyroiditis, Autoimmune-support-Hashimoto Disease', 'Heart Valve Diseases-develop-Constriction, Pathologic', 'Death-related-Heart Valve Diseases', 'Cerebral Infarction-receive-Cerebral Hemorrhage', 'Cerebral Infarction-receive-Death', 'Neoplasms-investigate-Drug-Related Side Effects and Adverse Reactions', 'Crohn Disease-associated-Breast Neoplasms', 'Breast Neoplasms-associated-Crohn Disease', 'Colitis, Ulcerative-associated-Breast Neoplasms', 'Breast Neoplasms-associated-Colitis, Ulcerative', 'Breast Neoplasms-sought-Inflammatory Bowel Diseases', 'Atrial Fibrillation-complicate-Acute Coronary Syndrome', 'Atrial Fibrillation-include-Hypertension', 'Atrial Fibrillation-identified-Hypertension', 'Acute Coronary Syndrome-include-Hypertension', 'Acute Coronary Syndrome-identified-Hypertension', 'Hypertriglyceridemia-associated-Diabetes Mellitus, Type 2', 'Diabetes Mellitus, Type 2-associated-Hypertriglyceridemia', 'Psoriasis-show-Infections', 'Dysbiosis-induce-Metabolic Diseases', 'Dysbiosis-lead-Infections', 'Dysbiosis-lead-Neoplasms', 'Dysbiosis-lead-Drug Hypersensitivity', 'Metabolic Diseases-induce-Infections', 'Metabolic Diseases-induce-Neoplasms', 'Metabolic Diseases-impede-Drug Hypersensitivity', 'Thyroid Cancer, Papillary-develop-Hypothyroidism', 'Hypothyroidism-develop-Hyponatremia', 'Alzheimer Disease-induce-Dementia', 'Neurodegenerative Diseases-induce-Dementia', 'Glioblastoma-apply-Glioma', 'Death-caused-Aortic Aneurysm', 'Chest Pain-caused-Aortic Aneurysm', 'Hemorrhage-caused-Aortic Aneurysm', 'Urinary Bladder Neck Obstruction-decrease-Prostatic Hyperplasia', 'Urinary Bladder Diseases-induced-Ischemia', 'Communicable Diseases-concentrate-Neoplasms', 'Dyspareunia-mistaken-Carcinoma, Squamous Cell', 'Dyspareunia-mistaken-Granuloma, Pyogenic', 'Dyspareunia-mistaken-Sarcoma, Kaposi', 'Urinary Bladder Diseases-aggravate-Urinary Incontinence', 'Cardiac Output, Low-outnumber-Death', 'Cardiac Output, Low-account-Death', 'Heart Rupture-occur-Hemorrhage', 'Myocardial Infarction-remain-Heart Rupture', 'Infarction, Anterior Cerebral Artery-remain-Heart Rupture', 'Heart Failure-associated-Syncope', 'Syncope-associated-Heart Failure', 'Heart Defects, Congenital-associated-Syncope', 'Syncope-associated-Heart Defects, Congenital', 'Angina Pectoris-associated-Syncope', 'Syncope-associated-Angina Pectoris', 'Stroke-prevent-Death', 'Skin Neoplasms-contribute-Neoplasms', 'Sotos Syndrome-contribute-Neoplasms', 'Neoplasms-mutated-Peutz-Jeghers Syndrome', 'Delirium-compared-Dementia', 'Demyelinating Diseases-manifest-Alzheimer Disease', 'Death-complicated-Shock, Cardiogenic', 'Hemorrhage-treat-Blood Platelet Disorders', 'Thrombocytopenia-treat-Blood Platelet Disorders', 'Sleep Wake Disorders-contribute-Inflammation', 'Sleep Wake Disorders-increase-Communicable Diseases', 'Inflammation-increase-Communicable Diseases', 'Cardiovascular Diseases-use-Malocclusion', 'Cardiovascular Diseases-use-Death', 'Hip Fractures-identified-Fractures, Bone', 'Chronic Disease-postpone-Death', 'Death-investigate-Delirium', 'Lymphoma, Non-Hodgkin-include-Lymphoma, B-Cell', 'Lymphoma, Non-Hodgkin-include-Lymphoma, Mantle-Cell', 'Lymphoma, Non-Hodgkin-include-Lymphoma', 'Lymphoma, Non-Hodgkin-include-Lymphoma, B-Cell, Marginal Zone', 'Lymphoma, Non-Hodgkin-include-Burkitt Lymphoma', 'Death-undergo-Aortic Aneurysm, Abdominal', 'Death-rescue-Aortic Aneurysm, Abdominal', 'Genetic Diseases, Inborn-suspected-Leukoencephalopathies', 'Pain-mediate-Obesity', 'Osteoporosis-present-Osteoarthritis', 'Neoplasms-tested-Retinal Neovascularization', 'Coronary Artery Disease-linked-Dementia', 'Coronary Artery Disease-associated-Communicable Diseases', 'Communicable Diseases-associated-Coronary Artery Disease', 'Ischemia-reperfuse-Cardiomyopathies', 'Heart Defects, Congenital-indicate-Nervous System Diseases', 'Heart Defects, Congenital-indicate-Death', 'Nervous System Diseases-indicate-Death', 'Death-predict-Malnutrition', 'Death-assess-Neoplasms', 'Brain Infarction-graded-Cerebral Small Vessel Diseases', 'Brain Infarction-identified-Atherosclerosis', 'Brain Infarction-identified-Arteriolosclerosis', 'Hypertension-play-Cardiovascular Diseases', 'Hypertension-play-Alzheimer Disease', 'Dyslipidemias-play-Cardiovascular Diseases', 'Dyslipidemias-play-Alzheimer Disease', 'Atherosclerosis-play-Cardiovascular Diseases', 'Atherosclerosis-play-Alzheimer Disease', 'Chronic Pain-associated-Chronic Disease', 'Chronic Disease-associated-Chronic Pain', 'Chronic Pain-associated-Joint Diseases', 'Joint Diseases-associated-Chronic Pain', 'Hematoma, Subdural, Chronic-influence-Craniocerebral Trauma', 'Dyspnea-followed-Fatigue', 'Cerebral Small Vessel Diseases-termed-Arteriolosclerosis', 'Cerebral Small Vessel Diseases-associated-Leukoaraiosis', 'Leukoaraiosis-associated-Cerebral Small Vessel Diseases', 'Arteriolosclerosis-associated-Stroke, Lacunar', 'Stroke, Lacunar-associated-Arteriolosclerosis', 'Arteriolosclerosis-associated-Leukoaraiosis', 'Leukoaraiosis-associated-Arteriolosclerosis', 'Arteriolosclerosis-associated-Dementia, Vascular', 'Dementia, Vascular-associated-Arteriolosclerosis', 'Carcinoma, Hepatocellular-linked-Hepatitis C, Chronic', 'Neoplasms-linked-Hepatitis C, Chronic', 'Disease-result-Perceptual Disorders', 'Exanthema-suggest-Skin Diseases', 'Death-topp-Stroke', 'Cardiovascular Diseases-topp-Stroke', 'Diabetes Mellitus-show-Necrosis', 'Hypertension-show-Necrosis', 'Thrombophilia-facilitate-Necrosis', 'Neutropenia-associated-Neoplasms', 'Neoplasms-associated-Neutropenia', 'Neurodegenerative Diseases-occur-Alzheimer Disease', 'Multiple Sclerosis-characterized-Inflammation', 'Demyelinating Diseases-characterized-Inflammation', 'Infections-lead-Encephalitis', 'Infections-lead-Heredodegenerative Disorders, Nervous System', 'Carcinoma, Hepatocellular-related-Obesity', 'Parkinson Disease-classify-Voice Disorders', 'Parkinson Disease-classify-Dysarthria', 'Hyperglycemia-develop-Metabolic Syndrome', 'Metabolic Syndrome-begin-Obesity', 'Metabolic Syndrome-begin-Dyslipidemias', 'Pneumonia-include-Vocal Cord Paralysis', 'Pain-decrease-Postoperative Hemorrhage', 'Endophthalmitis-arise-Liver Abscess, Pyogenic', 'Guillain-Barre Syndrome-include-Nervous System Diseases', 'Polyradiculopathy-include-Nervous System Diseases', 'Mononeuropathies-include-Nervous System Diseases', 'Cranial Nerve Diseases-include-Nervous System Diseases', 'Alzheimer Disease-represent-Disease', 'Disease-lead-Dementia', 'Disease-lead-Death', 'Infarction-occur-Death', 'Pulmonary Embolism-experience-Respiratory Insufficiency', 'Pulmonary Embolism-experience-Nervous System Diseases', 'Pulmonary Embolism-experience-Death', 'Venous Thrombosis-experience-Respiratory Insufficiency', 'Venous Thrombosis-experience-Nervous System Diseases', 'Venous Thrombosis-experience-Death', 'Coronary Artery Disease-related-Cerebrovascular Disorders', 'Stroke-related-Cerebrovascular Disorders', 'Obesity-linked-Dementia', 'Common Cold-associated-Death', 'Death-associated-Common Cold', 'Diabetes Mellitus-occur-Cardiovascular Diseases', 'Stroke-weighed-Hip Fractures', 'Xeroderma Pigmentosum-include-Skin Neoplasms', 'Xeroderma Pigmentosum-include-Nervous System Diseases', 'Memory Disorders-display-Alzheimer Disease', 'Aortic Valve Stenosis-result-Death', 'Neoplasms-accounting-Colorectal Neoplasms', 'Death-based-Wounds and Injuries', 'Myocardial Infarction-examine-Dyspnea', 'Muscular Dystrophies-become-Hyperkinesis', 'Alzheimer Disease-become-Hyperkinesis', 'Neoplasms-relapse-Leukemia, Lymphoid', 'Cerebral Infarction-calculated-Diabetes Mellitus', 'Cerebral Infarction-observed-Death', 'Diabetes Mellitus-rose-Cerebral Infarction', 'Osteoporosis-diagnose-Fractures, Bone', 'Bacterial Infections-lead-Sepsis', 'Lupus Erythematosus, Systemic-compare-Polyneuropathies', 'Lupus Erythematosus, Systemic-related-Polyneuropathies', 'Lupus Erythematosus, Systemic-characterized-Pain', 'Lupus Erythematosus, Systemic-characterized-Hypesthesia', 'Polyneuropathies-characterized-Pain', 'Polyneuropathies-characterized-Hypesthesia', 'Neoplasms-focused-Drug-Related Side Effects and Adverse Reactions', 'Deglutition Disorders-interpreted-Sarcopenia', 'Sarcopenia-include-Deglutition Disorders', 'Deglutition Disorders-related-Sarcopenia', 'Kidney Diseases-raise-Uremia', 'Uremia-raise-Cardiovascular Diseases', 'Death-associate-Cerebral Infarction', 'Cerebral Infarction-associate-Death', 'Wounds and Injuries-form-Muscular Dystrophies', 'Infections-acquire-Respiratory Tract Infections', 'Ulcer-live-Spinal Cord Injuries', 'Death-live-Spinal Cord Injuries', 'Ulcer-develop-Spinal Cord Injuries', 'Necrosis-follow-Inflammation', 'Necrosis-include-Fibrosis', 'Rosacea-lead-Corneal Diseases', 'Vascular Calcification-include-Cerebrovascular Disorders', 'Parkinson Disease-fail-Fractures, Bone', 'Parkinson Disease-address-Fractures, Bone', 'Fractures, Bone-prompt-Osteoporosis', 'Osteoporosis-treat-Parkinson Disease', 'Mitochondrial Diseases-cause-Biliary Dyskinesia', 'Fractures, Bone-propose-Movement Disorders', 'Seizures-delay-Hypertension', 'Death-associated-Pneumonia, Pneumocystis', 'Pneumonia, Pneumocystis-associated-Death', 'Death-associated-Toxoplasmosis, Cerebral', 'Toxoplasmosis, Cerebral-associated-Death', 'Atherosclerosis-linked-Obesity', 'Fractures, Bone-compared-Death', 'Fractures, Bone-base-Death', 'Sleep Wake Disorders-associated-HIV Infections', 'HIV Infections-associated-Sleep Wake Disorders', 'Alzheimer Disease-considered-Diabetes Mellitus, Type 2', 'Alzheimer Disease-considered-Metabolic Diseases', 'Nervous System Diseases-considered-Diabetes Mellitus, Type 2', 'Nervous System Diseases-considered-Metabolic Diseases', 'Diabetes Mellitus, Type 2-considered-Metabolic Diseases', 'Parkinson Disease-associated-Alzheimer Disease', 'Alzheimer Disease-associated-Parkinson Disease', 'Diabetes Mellitus, Type 2-lead-Alzheimer Disease', 'Death-hospitalized-Communicable Diseases', 'Death-developed-Neoplasms', 'Communicable Diseases-developed-Neoplasms', 'Thalassemia-suffer-Heart Failure', 'Thalassemia-confront-Bone Diseases', 'Heart Failure-confront-Bone Diseases', 'Hyperandrogenism-originate-Ovarian Neoplasms', 'Cold Injury-associated-Respiratory Tract Diseases', 'Respiratory Tract Diseases-associated-Cold Injury', 'Apnea-associated-Osteoporosis', 'Osteoporosis-associated-Apnea', 'Apnea-associated-Fractures, Bone', 'Fractures, Bone-associated-Apnea', 'Osteoporosis-observed-Apnea', 'Dementia-affect-Parkinson Disease', 'Stroke-affect-Parkinson Disease', 'Cardiovascular Diseases-associated-Coinfection', 'Coinfection-associated-Cardiovascular Diseases', 'Diarrhea-control-Infections', 'Gaucher Disease-lead-Death', 'Retroperitoneal Neoplasms-lead-Death', 'Arbovirus Infections-develop-Severe Acute Respiratory Syndrome', 'Infections-develop-Severe Acute Respiratory Syndrome', 'Hypertension-associated-Cataract', 'Cataract-associated-Hypertension', 'Hepatitis B-complicated-Thrombosis', 'Atrial Fibrillation-complicated-Thrombosis', 'Thrombosis-balance-Atrial Fibrillation', 'Peutz-Jeghers Syndrome-reveal-Neoplasms', 'Pelvic Floor Disorders-provoke-Pain', 'Pelvic Floor Disorders-provoke-Fecal Incontinence', 'Pelvic Floor Disorders-provoke-Constipation', 'Pelvic Floor Disorders-provoke-Sexual Dysfunction, Physiological', 'Metabolic Syndrome-associated-Coronary Artery Disease', 'Coronary Artery Disease-associated-Metabolic Syndrome', 'Death-increase-Coinfection', 'Death-increase-Pneumonia', 'Coinfection-associated-Pericarditis', 'Pericarditis-associated-Coinfection', 'Inflammation-associated-Albuminuria', 'Albuminuria-associated-Inflammation', 'Inflammation-contribute-Albuminuria', 'Tinnitus-associated-Nervous System Diseases', 'Nervous System Diseases-associated-Tinnitus', 'Nervous System Diseases-described-Hearing Loss', 'Osteoporosis-influence-Breast Neoplasms, Male', 'Polymyalgia Rheumatica-treated-Giant Cell Arteritis', 'Neurodegenerative Diseases-determined-Alzheimer Disease', 'Neoplasms-found-Death', 'Death-follow-Neoplasms', 'Atherosclerosis-seen-Inflammation', 'Diabetes Mellitus-seen-Inflammation', 'Neurodegenerative Diseases-seen-Inflammation', 'Parkinson Disease-seen-Inflammation', 'Death-result-Bacteremia', 'Bacteremia-comprise-Death', 'Wounds and Injuries-caused-Joint Diseases', 'Wounds and Injuries-caused-Osteoarthritis', 'Wounds and Injuries-characterized-Neurodegenerative Diseases', 'Neurodegenerative Diseases-include-Joint Diseases', 'Weight Loss-prevent-Heart Failure', 'Infections-remain-Communicable Diseases', 'Neurodegenerative Diseases-reveal-Amyotrophic Lateral Sclerosis', 'Cerebral Palsy-reduce-Contracture', 'Urinary Incontinence-associated-Heart Diseases', 'Heart Diseases-associated-Urinary Incontinence', 'Atrial Fibrillation-include-Dyspnea', 'Atrial Fibrillation-include-Fatigue', 'Stroke-convey-Atrial Fibrillation', 'Atrial Fibrillation-treat-Thromboembolism', 'Atrial Fibrillation-treat-Stroke', 'Paraproteinemias-administered-Anemia, Hemolytic, Autoimmune', 'Multiple Myeloma-administered-Anemia, Hemolytic, Autoimmune', 'Urinary Incontinence-defined-Cough', 'Obesity-decreased-Dementia', 'Hypoparathyroidism-occur-Hematoma', 'Hypoparathyroidism-occur-Paralysis', 'Hypoparathyroidism-occur-Infections', 'Pancreatitis-occur-Cholangitis', 'Pancreatitis-occur-Hemorrhage', 'Liver Diseases-include-Diabetes Mellitus, Type 2', 'Diabetes Mellitus-develop-Mastocytosis, Cutaneous', 'Pruritus-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-Pruritus', 'Diabetes Mellitus-exhibit-Bacterial Infections', 'Diabetes Mellitus-exhibit-Scabies', 'Atherosclerosis-considered-Neurodegenerative Diseases', 'Autoimmune Diseases-lead-Plaque, Atherosclerotic', 'Infections-followed-Neurologic Manifestations', 'Atrial Fibrillation-occur-Stroke', 'Atrial Fibrillation-occur-Thromboembolism', 'Stroke-underlie-Heart Diseases', 'Thromboembolism-underlie-Heart Diseases', 'Hypertension-associated-Hyponatremia', 'Hyponatremia-associated-Hypertension', 'Diabetes Mellitus-associated-Hyponatremia', 'Hyponatremia-associated-Diabetes Mellitus', 'Erectile Dysfunction-establish-Diabetes Mellitus', 'Erectile Dysfunction-predicted-Peripheral Nervous System Diseases', 'Erectile Dysfunction-predicted-Peripheral Vascular Diseases', 'Myotonic Dystrophy-associated-Erectile Dysfunction', 'Erectile Dysfunction-associated-Myotonic Dystrophy', 'Dementia-affected-Death, Sudden', 'Gerstmann-Straussler-Scheinker Disease-associated-Propionic Acidemia', 'Propionic Acidemia-associated-Gerstmann-Straussler-Scheinker Disease', 'Otitis-hear-Hearing Loss', 'Glucose Metabolism Disorders-know-Alzheimer Disease', 'Carcinoma, Squamous Cell-account-Esophageal Neoplasms', 'Diabetes Mellitus-involved-Diabetic Angiopathies', 'Diabetes Mellitus-include-Diabetic Angiopathies', 'Headache Disorders, Secondary-occur-Cholecystitis, Acute', 'Dysphonia-manage-Voice Disorders', 'Dysphonia-exert-Hearing Loss', 'Dysphonia-exert-Deglutition Disorders', 'Dysphonia-occur-Heredodegenerative Disorders, Nervous System', 'Pain, Postoperative-associated-Intestinal Atresia', 'Intestinal Atresia-associated-Pain, Postoperative', 'Pain, Postoperative-associated-Infections', 'Infections-associated-Pain, Postoperative', 'Breast Neoplasms-observe-Death', 'Muscular Diseases-characterized-Inflammation', 'Ovarian Neoplasms-store-Infertility, Female', 'Fever-include-Nervous System Diseases', 'Seizures-include-Nervous System Diseases', 'Parkinson Disease-lead-Atrophy', 'Parkinson Disease-lead-Death', 'Osteomyelitis-linked-Coronary Artery Disease', 'Tetany-present-Muscle Weakness', 'Sepsis-improve-Death', 'Vision Disorders-reduce-Death', 'Cardiovascular Diseases-emphasize-Inflammation', 'Infections-evaluated-Cleft Palate', 'Hypertension, Malignant-decrease-Cardiac Output, Low', 'Neoplasms-classify-Breast Neoplasms', 'Diabetes Mellitus-suggest-Ischemia', 'Ischemia-suggest-Hepatolenticular Degeneration', 'Cataract-include-Chronic Disease', 'Muscular Dystrophy, Duchenne-measure-Ataxia', 'Ataxia-correlated-Muscular Dystrophy, Duchenne', 'Ataxia-associated-Muscular Dystrophy, Duchenne', 'Muscular Dystrophy, Duchenne-associated-Ataxia', 'Parkinson Disease-characterized-Atrophy', 'Heart Failure-associate-Diabetes Mellitus', 'Diabetes Mellitus-associate-Heart Failure', 'Inflammation-lead-Hypertension', 'Lacrimal Duct Obstruction-categorized-Cataract', 'Lacrimal Duct Obstruction-categorized-Airway Obstruction', 'Cystic Fibrosis-remain-Death', 'Aortic Aneurysm, Thoracic-involved-Aneurysm', 'Inflammation-differentiate-Sepsis', 'Aortic Aneurysm, Thoracic-include-Cardiovascular Diseases', 'Aortic Aneurysm, Thoracic-associated-Hypertension', 'Hypertension-associated-Aortic Aneurysm, Thoracic', 'Cardiovascular Diseases-considered-Death', 'Craniocerebral Trauma-include-Rupture', 'Glycogen Storage Disease Type II-prevent-Vision Disorders', 'Glycogen Storage Disease Type II-use-Dysautonomia, Familial', 'Inflammation-regulate-Myalgia', 'Neoplasms-include-Muscular Diseases', 'Pulmonary Disease, Chronic Obstructive-include-Muscular Diseases', 'Muscular Diseases-include-Inflammation', 'Muscular Diseases-occur-Inflammation', 'Neoplasms-occur-Inflammation', 'Pulmonary Disease, Chronic Obstructive-occur-Inflammation', 'Inflammation-trigger-Muscular Diseases', 'Pain-targeting-Sleep Initiation and Maintenance Disorders', 'Cardiomyopathies-constitute-Hypertension', 'Cardiomyopathies-constitute-Uremia', 'Heart Valve Diseases-constitute-Hypertension', 'Heart Valve Diseases-constitute-Uremia', 'Hemorrhage-prevent-Thrombosis', 'Nocturia-given-Death', 'Diabetes Mellitus-given-Death', 'Diabetes Mellitus-appear-Klebsiella Infections', 'HIV Infections-summarize-Cardiovascular Diseases', 'HIV Infections-summarize-Heart Failure', 'HIV Infections-summarize-Hypertension', 'HIV Infections-summarize-Coronary Artery Disease', 'HIV Infections-summarize-Myocardial Infarction', 'HIV Infections-summarize-Stroke', 'HIV Infections-summarize-Lung Diseases', 'HIV Infections-summarize-Pulmonary Arterial Hypertension', 'Cardiovascular Diseases-summarize-Heart Failure', 'Cardiovascular Diseases-summarize-Coronary Artery Disease', 'Renal Insufficiency, Chronic-occur-Sarcopenia', 'Cardiovascular Diseases-summarize-Myocardial Infarction', 'Cardiovascular Diseases-summarize-Stroke', 'Cardiovascular Diseases-summarize-Lung Diseases', 'Aneurysm-develop-Hypoxia', 'Tick-Borne Diseases-driven-Infections', 'Spinal Cord Injuries-fall-Cardiac Output, Low', 'Uterine Cervicitis-fall-Cardiac Output, Low', 'Wounds and Injuries-result-Quadriplegia', 'Hypothalamic Neoplasms-impact-Memory Disorders', 'Diabetes Mellitus-focus-Atherosclerosis', 'Diabetes Mellitus-recognised-Vascular Calcification', 'Atherosclerosis-recognised-Vascular Calcification', 'Atherosclerosis-focus-Death', 'Vascular Calcification-recognised-Death', 'Calcinosis-related-Inflammation', 'Calcinosis-related-Diabetes Mellitus', 'Bone Diseases, Metabolic-occur-Chronic Kidney Disease-Mineral and Bone Disorder', 'Aortic Arch Syndromes-contribute-Brain Infarction', 'Sleep Initiation and Maintenance Disorders-report-Fatigue', 'Hearing Loss-hear-Sensation Disorders', 'Pain, Postoperative-treated-Fractures, Bone', 'Tauopathies-increased-Retinal Degeneration', 'Tauopathies-increased-Supranuclear Palsy, Progressive', 'Atherosclerosis-characterize-Heart Arrest', 'Obesity-consist-Hyperandrogenism', 'Obesity-consist-Hypogonadism', 'Gonadal Disorders-lead-Sarcopenia', 'Infections-heal-Ulcer', 'HIV Infections-develop-Metabolic Diseases', 'HIV Infections-lead-Diabetes Mellitus', 'Metabolic Diseases-lead-Diabetes Mellitus', 'Leukoaraiosis-caused-Leukoencephalopathies', 'Fascioliasis-analysed-Infections', 'Anemia-observed-Renal Insufficiency', 'Hematologic Diseases-underlie-Myelodysplastic Syndromes', 'Hematologic Diseases-found-Anemia', 'Myelodysplastic Syndromes-underlie-Anemia', 'Myelodysplastic Syndromes-underlie-Thrombocytopenia', 'Myelodysplastic Syndromes-underlie-Leukopenia', 'Thrombocytopenia-include-Anemia', 'Leukopenia-include-Anemia', 'Fractures, Bone-defined-Musculoskeletal Diseases', 'Fractures, Bone-compare-Musculoskeletal Diseases', 'Alzheimer Disease-seen-TDP-43 Proteinopathies', 'Alzheimer Disease-seen-Sclerosis', 'Dementia-seen-Sclerosis', 'TDP-43 Proteinopathies-seen-Sclerosis', 'Cerebrovascular Disorders-include-Neurodegenerative Diseases', 'Carcinoma, Hepatocellular-associated-Carcinogenesis', 'Carcinogenesis-associated-Carcinoma, Hepatocellular', 'Osteoarthritis-bringe-Pain', 'Death-throw-Dementia', 'Cardiomyopathies-promote-Cardiovascular Diseases', 'Dyskinesia, Drug-Induced-associated-REM Sleep Behavior Disorder', 'REM Sleep Behavior Disorder-associated-Dyskinesia, Drug-Induced', 'Dyskinesia, Drug-Induced-wear-REM Sleep Behavior Disorder', 'Epilepsy-diagnose-Common Cold', 'Infections-associated-Duodenal Diseases', 'Duodenal Diseases-associated-Infections', 'Infections-associated-Thrombocytopenia', 'Thrombocytopenia-associated-Infections', 'Hypoglycemia-lead-Fractures, Bone', 'Kidney Diseases-contribute-Hypoglycemia', 'Diabetes Mellitus, Type 2-contribute-Hypoglycemia', 'Adenoma-defined-Adenomatous Polyposis Coli', 'Adenomatous Polyposis Coli-defined-Neoplasms', 'Adenoma-defined-Neoplasms', 'Atrophy-help-Alzheimer Disease', 'Renal Insufficiency, Chronic-become-Death', 'Renal Insufficiency, Chronic-linked-Diabetes Mellitus', 'Renal Insufficiency, Chronic-linked-Hypertension', 'Renal Insufficiency, Chronic-linked-Obesity', 'Critical Illness-associated-Memory Disorders', 'Memory Disorders-associated-Critical Illness', 'Heart Failure-associated-Dementia', 'Dementia-associated-Heart Failure', 'Death-observed-Neoplasm Invasiveness', 'Death-lead-Pneumonia, Aspiration', 'Death-lead-Pneumonia', 'Death-lead-Airway Obstruction', 'Osteoporosis-publish-Immunologic Deficiency Syndromes', 'Osteoporosis-publish-Bone Diseases', 'Immunologic Deficiency Syndromes-attributed-Taste Disorders', 'Muscle Weakness-defined-Sarcopenia', 'Fractures, Spontaneous-suffer-Pulmonary Disease, Chronic Obstructive', 'Neoplasms-do-Death', 'Drug-Related Side Effects and Adverse Reactions-minimize-Neoplasms', 'Prostatic Neoplasms-result-Drug-Related Side Effects and Adverse Reactions', 'Neutropenia-diagnosed-Breast Neoplasms', 'Nausea-diagnosed-Breast Neoplasms', 'Anemia-diagnosed-Breast Neoplasms', 'Osteoporosis-diagnosed-Breast Neoplasms', 'Breast Neoplasms-diagnosed-Sleep Initiation and Maintenance Disorders', 'Breast Neoplasms-diagnosed-Fatigue', 'Osteoporosis-cause-Bone Neoplasms', 'Leukemia, Myeloid, Acute-used-Neoplasms', 'Leukemia, Myeloid, Acute-investigate-Neoplasms', 'Diabetes Mellitus-associated-Aortic Aneurysm', 'Aortic Aneurysm-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-Aortic Aneurysm, Abdominal', 'Aortic Aneurysm, Abdominal-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-Rupture', 'Rupture-associated-Diabetes Mellitus', 'Fatigue-initiate-Fractures, Bone', 'Fatigue-investigated-Fractures, Bone', 'Fatigue-followed-Fractures, Bone', 'Diabetes Mellitus-include-Aneurysm', 'Diabetes Mellitus, Type 2-associated-Dementia, Vascular', 'Dementia, Vascular-associated-Diabetes Mellitus, Type 2', 'Diabetes Mellitus, Type 2-associated-Alzheimer Disease', 'Alzheimer Disease-associated-Diabetes Mellitus, Type 2', 'Dementia, Vascular-associated-Alzheimer Disease', 'Alzheimer Disease-associated-Dementia, Vascular', 'Erectile Dysfunction-include-Alcoholism', 'Erectile Dysfunction-include-Obesity, Abdominal', 'Erectile Dysfunction-include-Diabetes Mellitus', 'Erectile Dysfunction-include-Hyperlipidemias', 'Erectile Dysfunction-include-Hypertension', 'Erectile Dysfunction-include-Metabolic Syndrome', 'Infections-approach-Fractures, Bone', 'Neurodegenerative Diseases-lead-Blindness', 'Retinal Degeneration-prevent-Blindness', 'Diabetic Nephropathies-account-Diabetes Mellitus, Type 2', 'Hypoxia-represent-Diabetic Nephropathies', 'Diabetes Mellitus-induce-Hypoxia', 'Cardiovascular Diseases-present-Myocardial Infarction', 'Irritable Bowel Syndrome-characterized-Abdominal Pain', 'Irritable Bowel Syndrome-characterized-Tics', 'Metabolic Diseases-remain-Polycystic Ovary Syndrome', 'Signs and Symptoms, Respiratory-classified-Rhinitis', 'Signs and Symptoms, Respiratory-classified-Neoplasms', 'Parkinsonian Disorders-defined-Hypokinesia', 'Parkinsonian Disorders-defined-Muscle Rigidity', 'Parkinsonian Disorders-associated-Cerebrovascular Disorders', 'Cerebrovascular Disorders-associated-Parkinsonian Disorders', 'Parkinsonian Disorders-defined-Tremor', 'Parkinsonian Disorders-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-Parkinsonian Disorders', 'Death-affect-Coma', 'Death-lead-Cardiovascular Diseases', 'Death-lead-Osteoporosis', 'Death-lead-Sexual Dysfunction, Physiological', 'Dementia-increase-Dementia, Vascular', 'Embolism-included-Atrial Fibrillation', 'Sepsis-lead-Seizures', 'Azoospermia-detect-Airway Obstruction', 'Azoospermia-detect-Bile Duct Diseases', 'Hypogonadism-related-Metabolic Diseases', 'Headache Disorders, Secondary-include-Death', 'Lung Diseases-include-Death', 'Atrial Fibrillation-include-Death', 'Sleep Wake Disorders-include-Cough', 'Colorectal Neoplasms-associated-Adenoma', 'Adenoma-associated-Colorectal Neoplasms', 'Kidney Neoplasms-associated-Adenoma', 'Adenoma-associated-Kidney Neoplasms', 'Sleep Initiation and Maintenance Disorders-found-Alzheimer Disease', 'Sleep Initiation and Maintenance Disorders-associated-Lafora Disease', 'Lafora Disease-associated-Sleep Initiation and Maintenance Disorders', 'Alzheimer Disease-present-Restless Legs Syndrome', 'Alzheimer Disease-present-Sleep Initiation and Maintenance Disorders', 'Sleep Wake Disorders-associated-Lafora Disease', 'Lafora Disease-associated-Sleep Wake Disorders', 'Sleep Wake Disorders-associated-Restless Legs Syndrome', 'Restless Legs Syndrome-associated-Sleep Wake Disorders', 'Sleep Wake Disorders-related-Dementia', 'Dementia-associated-Restless Legs Syndrome', 'Restless Legs Syndrome-associated-Dementia', 'Sleep Wake Disorders-present-Sleep Initiation and Maintenance Disorders', 'Death-link-Dementia', 'Death-defined-Dementia', 'Sarcoidosis-associated-Autoimmune Diseases', 'Autoimmune Diseases-associated-Sarcoidosis', 'Sarcoidosis-associated-Pulmonary Embolism', 'Pulmonary Embolism-associated-Sarcoidosis', 'Sarcoidosis-associated-Neoplasms', 'Neoplasms-associated-Sarcoidosis', 'Movement Disorders-create-Musculoskeletal Diseases', 'Stroke-subtyp-Ischemia', 'Neurologic Manifestations-include-Stroke', 'Stroke-subtyp-Hemorrhage', 'Pain-encountered-Pleural Effusion', 'Progeria-facilitate-Weight Gain', 'Pneumonia-underlie-Lung Diseases', 'Thoracic Outlet Syndrome-contribute-Pain', 'Inflammation-reduce-Eosinophilia', 'Fractures, Bone-include-Pain', 'Fractures, Bone-include-Hip Dislocation, Congenital', 'Meningitis, Bacterial-become-Pneumonia, Pneumocystis', 'Lymphoma, Primary Effusion-linked-Sarcoma, Kaposi', 'Venous Thrombosis-suffer-Kidney Failure, Chronic', 'Stenosis, Pulmonary Artery-suffer-Kidney Failure, Chronic', 'Neoplasms-seem-Breast Neoplasms', 'Foot Ulcer-diagnosed-Rare Diseases', 'Cerebrovascular Disorders-prevent-Cardiovascular Diseases', 'Hypertension-show-Brain Infarction', 'Metabolic Syndrome-linked-Cerebrovascular Disorders', 'Carotid Stenosis-show-Brain Infarction', 'Renal Insufficiency, Chronic-show-Brain Infarction', 'Metabolic Syndrome-show-Brain Infarction', 'Death-treated-Obesity', 'Alzheimer Disease-defined-Nerve Degeneration', 'Diabetes Mellitus, Type 2-lead-Death', 'Dyslipidemias-lead-Death', 'Cerebrovascular Disorders-associated-Aneurysm', 'Aneurysm-associated-Cerebrovascular Disorders', 'Epilepsy-lead-Hypotension', 'Breast Neoplasms-classified-Neoplasms', 'Pancreatic Neoplasms-equal-Death', 'Neoplasms-equal-Death', 'Myopia-classified-Hyperopia', 'Hypoxia-triggered-Headache', 'Dyspnea-triggered-Headache', 'Pain-include-Arthritis, Rheumatoid', 'Death-infected-Hepatitis C, Chronic', 'Death-rise-Obesity', 'Carcinoma, Hepatocellular-infected-Hepatitis C, Chronic', 'Carcinoma, Hepatocellular-rise-Obesity', 'Hepatitis C, Chronic-infected-Obesity', 'Carcinoma, Hepatocellular-remain-Death', 'Hemangioma-overlie-Carcinoma, Merkel Cell', 'Meningeal Neoplasms-considered-Hemangioma', 'Neoplasms-considered-Hemangioma', 'Cardiomyopathy, Hypertrophic-remain-Death, Sudden', 'Cardiomyopathy, Hypertrophic-remain-Heart Failure', 'Cardiomyopathy, Hypertrophic-remain-Airway Obstruction', 'Cardiomyopathy, Hypertrophic-progress-Heart Diseases', 'Cardiomyopathy, Hypertrophic-remain-Atrial Fibrillation', 'Cardiomyopathy, Hypertrophic-remain-Stroke', 'Death, Sudden-include-Cardiomyopathy, Hypertrophic', 'Cardiomyopathy, Hypertrophic-include-Headache Disorders, Secondary', 'Cardiomyopathy, Hypertrophic-alleviate-Headache Disorders, Secondary', 'Cardiomyopathy, Hypertrophic-include-Airway Obstruction', 'Cardiomyopathy, Hypertrophic-abolish-Airway Obstruction', 'Cardiomyopathy, Hypertrophic-include-Atrial Fibrillation', 'Cardiomyopathy, Hypertrophic-control-Atrial Fibrillation', 'Death, Sudden-alleviate-Headache Disorders, Secondary', 'Death, Sudden-abolish-Airway Obstruction', 'Death, Sudden-control-Atrial Fibrillation', 'Headache Disorders, Secondary-abolish-Airway Obstruction', 'Headache Disorders, Secondary-control-Atrial Fibrillation', 'Airway Obstruction-control-Atrial Fibrillation', 'Cardiomyopathy, Hypertrophic-transform-Cardiovascular Diseases', 'Smoke Inhalation Injury-burn-Death', 'Sleep Initiation and Maintenance Disorders-underlie-AIDS Arteritis, Central Nervous System', 'Nerve Degeneration-linked-AIDS Arteritis, Central Nervous System', 'Muscular Diseases-termed-Sarcopenia', 'Mastocytosis, Systemic-associated-Breast Neoplasms, Male', 'Breast Neoplasms, Male-associated-Mastocytosis, Systemic', 'Obesity-exhibit-Death', 'Hyperuricemia-associated-Hypertension', 'Hypertension-associated-Hyperuricemia', 'Prediabetic State-diagnosed-Glucose Intolerance', 'Neurodegenerative Diseases-lead-Cerebellar Diseases', 'Neurodegenerative Diseases-lead-Nervous System Diseases', 'Neurodegenerative Diseases-lead-Hearing Loss', 'Obesity-diagnosed-Osteoporosis', 'Infections-manage-Chronic Disease', 'Immunologic Deficiency Syndromes-treat-Chronic Disease', 'Immunologic Deficiency Syndromes-manage-Chronic Disease', 'Conjunctivitis, Allergic-connected-Dry Eye Syndromes', 'Acute Kidney Injury-base-Kidney Diseases', 'Weight Loss-compare-Diabetes Mellitus', 'Cerebrovascular Disorders-associated-Hypokinesia', 'Hypokinesia-associated-Cerebrovascular Disorders', 'Cerebrovascular Disorders-associated-Muscle Rigidity', 'Muscle Rigidity-associated-Cerebrovascular Disorders', 'Hypokinesia-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-Hypokinesia', 'Cardiovascular Diseases-associated-Muscle Rigidity', 'Muscle Rigidity-associated-Cardiovascular Diseases', 'Mitochondrial Diseases-categorized-Exanthema', 'Mitochondrial Diseases-categorized-Pigmentation Disorders', 'Aneuploidy-see-Turner Syndrome', 'Aneuploidy-range-Intellectual Disability', 'Aneuploidy-range-Growth Disorders', 'Aneuploidy-range-Neoplasms', 'Aneuploidy-range-Death', 'Intellectual Disability-range-Neoplasms', 'Pulmonary Disease, Chronic Obstructive-impact-Heart Failure', 'Delirium-follow-Postoperative Nausea and Vomiting', 'Postoperative Nausea and Vomiting-follow-Nausea', 'Postoperative Nausea and Vomiting-follow-Pain, Postoperative', 'Immunologic Deficiency Syndromes-afflict-Obesity', 'Immunologic Deficiency Syndromes-afflict-Diabetes Mellitus', 'Immunologic Deficiency Syndromes-afflict-Hypertension', 'Infections-lead-Hepatitis B', 'Infections-lead-Viremia', 'Hepatitis B-lead-Viremia', 'Death-confirm-Parkinson Disease', 'Obesity-increase-Metabolic Syndrome', 'Erectile Dysfunction-increase-Metabolic Syndrome', 'Stroke-diagnosed-Dementia', 'Dementia-derived-Stroke', 'Spastic Paraplegia, Hereditary-associated-Dementia', 'Dementia-associated-Spastic Paraplegia, Hereditary', 'Spastic Paraplegia, Hereditary-associated-Stroke', 'Stroke-associated-Spastic Paraplegia, Hereditary', 'Spastic Paraplegia, Hereditary-associated-Dementia, Vascular', 'Dementia, Vascular-associated-Spastic Paraplegia, Hereditary', 'Hemophilia A-protect-Myocardial Infarction', 'Hemophilia A-protect-Stroke', 'Hemophilia A-protect-Venous Thromboembolism', 'Cardiovascular Diseases-treat-Hemophilia A', 'Hemophilia A-manage-Coronary Artery Disease', 'HIV Infections-use-Immunologic Deficiency Syndromes', 'Seizures-found-Stroke', 'Infections-cause-Seizures', 'Amebiasis-include-Communicable Diseases', 'Malaria-include-Communicable Diseases', 'Leishmaniasis-include-Communicable Diseases', 'Paracoccidioidomycosis-include-Communicable Diseases', 'Dementia-mimic-Drug Hypersensitivity', 'Alzheimer Disease-mimic-Drug Hypersensitivity', 'Pneumococcal Infections-defined-Pneumonia', 'Hypoalbuminemia-associated-Pneumococcal Infections', 'Pneumococcal Infections-associated-Hypoalbuminemia', 'Azotemia-associated-Pneumococcal Infections', 'Pneumococcal Infections-associated-Azotemia', 'Atherosclerosis-predispose-Hypertension, Pulmonary', 'Kidney Neoplasms-associated-Coronary Artery Disease', 'Coronary Artery Disease-associated-Kidney Neoplasms', 'Death-assess-Sarcopenia', 'Giardiasis-identified-Immunologic Deficiency Syndromes', 'Giardiasis-present-Diarrhea', 'Immunologic Deficiency Syndromes-include-HIV Infections', 'Immunologic Deficiency Syndromes-include-Acquired Immunodeficiency Syndrome', 'Diabetes Mellitus-describe-Hypertension', 'Hypotension, Orthostatic-associate-Hypertension', 'Hypertension-associate-Hypotension, Orthostatic', 'Hypertension-compare-Hypotension, Orthostatic', 'HIV Infections-transmit-Infections', 'Atrophy-arise-Diabetes Mellitus, Type 2', 'Memory Disorders-presented-Atrophy', 'Dementia-arise-Diabetes Mellitus, Type 2', 'Memory Disorders-presented-Dementia', 'Memory Disorders-presented-Diabetes Mellitus, Type 2', 'Fractures, Bone-improve-Hip Fractures', 'Bone Neoplasms-explain-Fractures, Bone', 'Myocardial Infarction-prevent-Ventricular Remodeling', 'Atherosclerosis-predict-Cardiovascular Diseases', 'Obesity-predict-Chronic Disease', 'Brain Diseases-associated-Drug Hypersensitivity', 'Drug Hypersensitivity-associated-Brain Diseases', 'Diabetes Mellitus-associated-Brain Diseases', 'Brain Diseases-associated-Diabetes Mellitus', 'Hypertriglyceridemia-excluded-Diabetes Mellitus', 'Hypertension-associated-Infarction', 'Infarction-associated-Hypertension', 'White Dot Syndromes-compare-Fibrosis', 'Meningitis-resemble-Stroke', 'Infections-involved-Hodgkin Disease', 'Neoplasms-examine-Hodgkin Disease', 'Death-show-Acute Kidney Injury', 'Inflammation-correlate-Multiple Sclerosis', 'Immunologic Deficiency Syndromes-improve-Adenocarcinoma', 'Immunologic Deficiency Syndromes-play-Heart Failure', 'Alzheimer Disease-assess-Diabetes Mellitus', 'Inflammation-create-Neoplasms', 'Death-associated-Pneumonia, Aspiration', 'Pneumonia, Aspiration-associated-Death', 'Ankle Injuries-reduced-Pulmonary Disease, Chronic Obstructive', 'Diabetes Mellitus-avoid-Death', 'Carcinogenesis-simulate-Retinoblastoma', 'Immunologic Deficiency Syndromes-reported-Spinal Cord Injuries', 'Rhinitis, Allergic-described-Intestinal Polyposis', 'Oculocerebrorenal Syndrome-result-Hepatitis C', 'Chronic Disease-contribute-Sarcopenia', 'Infections-include-Respiratory Insufficiency', 'Respiratory Insufficiency-increase-Pulmonary Disease, Chronic Obstructive', 'Inflammation-prevent-Hypertrophy, Left Ventricular', 'Hypertrophy, Left Ventricular-risk-Hypovolemia', 'Osteoarthritis, Hip-associated-Pain', 'Pain-associated-Osteoarthritis, Hip', 'Hypoalbuminemia-exacerbated-Edema', 'Hypoalbuminemia-exacerbated-Weight Gain', 'Bone Diseases, Metabolic-associated-Neoplasms', 'Neoplasms-associated-Bone Diseases, Metabolic', 'Hypotension, Orthostatic-defined-Headache', 'Peptic Ulcer-result-Death', 'Infections-play-Gastrointestinal Diseases', 'Death-make-Prostatic Neoplasms', 'Death-reduced-Exanthema Subitum', 'Obesity-assess-Weight Loss', 'Metabolic Syndrome-assess-Weight Loss', 'Alzheimer Disease-equate-Dementia', 'Osteoporosis-lagge-Chronic Disease', 'Carcinoma, Acinar Cell-related-Inflammation', 'Fibrosis-related-Inflammation', 'Hypercapnia-investigate-Pulmonary Disease, Chronic Obstructive', 'Hypercapnia-depend-Pulmonary Disease, Chronic Obstructive', 'Diabetes Mellitus-confined-Heart Failure', 'Neurodegenerative Diseases-constitute-Vision Disorders', 'Neurodegenerative Diseases-exhibit-Glycogen Storage Disease Type II', 'Vision Disorders-exhibit-Glycogen Storage Disease Type II', 'Death-recognized-Kidney Failure, Chronic', 'Sleep Wake Disorders-diagnose-Cardiovascular Diseases', 'Sleep Wake Disorders-diagnose-Obesity', 'Sleep Wake Disorders-identified-Obesity', 'Sleep Wake Disorders-identified-Cardiovascular Diseases', 'Obesity-related-Sleepiness', 'Kidney Failure, Chronic-associated-Coronary Artery Disease', 'Coronary Artery Disease-associated-Kidney Failure, Chronic', 'Kidney Failure, Chronic-associated-Stroke', 'Stroke-associated-Kidney Failure, Chronic', 'Kidney Failure, Chronic-associated-Heart Failure', 'Heart Failure-associated-Kidney Failure, Chronic', 'Kidney Failure, Chronic-associated-Atrial Fibrillation', 'Atrial Fibrillation-associated-Kidney Failure, Chronic', 'Kidney Failure, Chronic-associated-Death, Sudden, Cardiac', 'Death, Sudden, Cardiac-associated-Kidney Failure, Chronic', 'Kidney Failure, Chronic-associated-Hypertension, Pulmonary', 'Hypertension, Pulmonary-associated-Kidney Failure, Chronic', 'Kidney Failure, Chronic-associated-Heart Valve Diseases', 'Heart Valve Diseases-associated-Kidney Failure, Chronic', 'Hypertension-establish-Coronary Artery Disease', 'Hypertension-establish-Peripheral Vascular Diseases', 'Hypertension-establish-Hypertrophy, Left Ventricular', 'Diabetes Mellitus-establish-Coronary Artery Disease', 'Diabetes Mellitus-establish-Peripheral Vascular Diseases', 'Diabetes Mellitus-establish-Hypertrophy, Left Ventricular', 'Infections-result-Diarrhea', 'Alzheimer Disease-suggest-Brain Diseases', 'Death-caused-Staphylococcal Infections', 'Inflammation-cause-Parkinson Disease', 'Pneumonia-cause-Inflammation', 'Inflammation-account-Death', 'Carcinoma, Basal Cell-observed-Carcinoma, Squamous Cell', 'Pain-increase-Wounds and Injuries', 'Edema-increase-Wounds and Injuries', 'Hypoxia-caused-Communicable Diseases', 'Hypoxia-caused-Sepsis', 'Hypoxia-caused-Dehydration', 'Hypoxia-caused-Drug Overdose', 'Acidosis, Lactic-associated-Critical Illness', 'Critical Illness-associated-Acidosis, Lactic', 'Osteoarthritis-reached-Arthralgia', 'Brain Injuries, Traumatic-hospitalized-Wounds and Injuries', 'Aphasia-classified-Alzheimer Disease', 'Dementia-reported-Hypertension', 'Epilepsy-experience-Seizures', 'HIV Infections-depict-Inflammation', 'Neoplasms-result-Heart Arrest', 'Mouth Diseases-favor-Infections', 'Lymphoma-include-Lymphoma, B-Cell', 'Lymphoma-include-Leukemia, Lymphoid', 'Fibromyalgia-include-Dystonia', 'Fibromyalgia-evaluate-Dystonia', 'Pancreatic Neoplasms-treated-Neoplasms', 'Hypertension-demonstrate-Death', 'Aortic Aneurysm, Abdominal-give-Death', 'Telangiectasia, Hereditary Hemorrhagic-treated-Epistaxis', 'Inflammation-acquire-Abnormalities, Drug-Induced', 'Hypertension-associated-Thrombosis', 'Thrombosis-associated-Hypertension', 'Crystal Arthropathies-associated-Inflammation', 'Inflammation-associated-Crystal Arthropathies', 'Crystal Arthropathies-associated-Atherosclerosis', 'Atherosclerosis-associated-Crystal Arthropathies', 'Ankle Injuries-exhibit-Movement Disorders', 'Sarcopenia-contribute-Diabetes Mellitus', 'Peripheral Nervous System Diseases-cause-Fractures, Bone', 'Sarcopenia-identified-Osteoporosis', 'Edema-develop-Acute Kidney Injury', 'Fibrosis-associate-Vascular Calcification', 'Vascular Calcification-associate-Fibrosis', 'Neurodegenerative Diseases-lead-Epilepsy', 'Nerve Degeneration-related-Epilepsy', 'Nerve Degeneration-appear-Epilepsy', 'Inflammation-contribute-Liver Diseases', 'Drug-Related Side Effects and Adverse Reactions-contribute-Liver Diseases', 'Hip Fractures-compare-Craniocerebral Trauma', 'Hip Fractures-sustain-Craniocerebral Trauma', 'Obesity, Abdominal-linked-Hypertension', 'Obesity, Abdominal-linked-Diabetes Mellitus, Type 2', 'Hypotension-accompanied-Metabolic Syndrome', 'Inflammation-affect-Alzheimer Disease', 'Vision Disorders-perform-Glaucoma', 'Pneumonia, Aspiration-associated-Pneumonia', 'Pneumonia-associated-Pneumonia, Aspiration', 'Pneumonia, Aspiration-related-Pneumonia', 'Nocturnal Enuresis-resolved-Nocturia', 'Pneumonia, Aspiration-considered-Pneumonia', 'Parkinson Disease, Secondary-comprise-Parkinson Disease', 'Sleep Deprivation-associated-Genetic Diseases, Inborn', 'Genetic Diseases, Inborn-associated-Sleep Deprivation', 'Pain-include-Heart Block', 'Obesity-correlated-Thinness', 'Death-follow-Dementia', 'Death-include-Dementia', 'Cardiac Output, Low-fall-Hypesthesia', 'Lipodystrophy-associated-Dyslipidemias', 'Dyslipidemias-associated-Lipodystrophy', 'Lipodystrophy-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-Lipodystrophy', 'Lipodystrophy-associated-Hypertension', 'Hypertension-associated-Lipodystrophy', 'Ocular Motility Disorders-distributed-Ulcer', 'Infections-cause-Meningoencephalitis', 'Prostatic Neoplasms-treated-Drug-Related Side Effects and Adverse Reactions', 'Wounds and Injuries-ease-Fractures, Bone', 'Prostatic Neoplasms-describe-Neoplasms', 'Metabolic Syndrome-increase-Atherosclerosis', 'Metabolic Syndrome-include-Cardiovascular Diseases', 'Metabolic Syndrome-include-Glucose Metabolism Disorders', 'Glucose Metabolism Disorders-include-Cardiovascular Diseases', 'Pain-known-Cancer Pain', 'Pain-known-Breakthrough Pain', 'Cancer Pain-known-Pain', 'Cancer Pain-known-Breakthrough Pain', 'Pain-assessed-Breakthrough Pain', 'HIV Infections-change-Chronic Disease', 'Bloom Syndrome-associated-Neoplasms', 'Neoplasms-associated-Bloom Syndrome', 'Bloom Syndrome-associated-Growth Disorders', 'Growth Disorders-associated-Bloom Syndrome', 'Genomic Instability-associated-Neoplasms', 'Neoplasms-associated-Genomic Instability', 'Genomic Instability-associated-Growth Disorders', 'Growth Disorders-associated-Genomic Instability', 'Renal Insufficiency-receive-Atrial Fibrillation', 'Drug-Related Side Effects and Adverse Reactions-encountered-Neurologic Manifestations', 'Drug-Related Side Effects and Adverse Reactions-encountered-Death', 'Ulcer-develop-Pneumonia', 'Colorectal Neoplasms-contribute-Neoplasms', 'Death-attributed-Skin Neoplasms', 'Death-associated-Skin Neoplasms', 'Skin Neoplasms-associated-Death', 'Craniosynostoses-undergo-Peritoneal Neoplasms', 'Dementia-compared-Delirium', 'Delirium-compare-Dementia', 'Nervous System Diseases-lead-Blindness', 'Optic Nerve Diseases-lead-Blindness', 'Death-lead-Blindness', 'Nerve Degeneration-lead-Blindness', 'Periodontitis-decrease-Cardiac Output, Low', 'Bone Neoplasms-decrease-Cardiac Output, Low', 'Death-compare-Carcinoma, Non-Small-Cell Lung', 'Death-compare-Pulmonary Disease, Chronic Obstructive', 'Alzheimer Disease-found-Meningocele', 'Brain Diseases-characterized-Renal Tubular Transport, Inborn Errors', 'Alzheimer Disease-characterized-Renal Tubular Transport, Inborn Errors', 'Synovitis-predispose-Fractures, Bone', 'Neoplasms-include-Neoplasm Invasiveness', 'Neoplasms-include-Meningeal Neoplasms', 'Neoplasm Invasiveness-include-Meningeal Neoplasms', 'Meningeal Neoplasms-include-Neoplasms', 'Dementia-live-Delirium', 'Dementia-live-Malnutrition', 'Infections-seen-Radial Neuropathy', 'Heart Failure-develop-Inflammation', 'Infections-survive-Neoplasms', 'Infections-occur-HIV Infections', 'Cerebral Amyloid Angiopathy-compare-Cerebral Hemorrhage', 'Heart Valve Diseases-include-Mitral Valve Stenosis', 'Skin Diseases-base-Neoplasms', 'Skin Diseases-impact-Neoplasms', 'Pain-show-Headache Disorders, Secondary', 'Stroke-prevent-Coronary Artery Disease', 'Heredodegenerative Disorders, Nervous System-predict-Dementia', 'Death-identified-Bronchitis', 'Death-identified-Lung Diseases', 'Death-identified-Asthma', 'Acquired Immunodeficiency Syndrome-review-HIV Infections', 'Jaw Diseases-indicated-Sleep Apnea, Obstructive', 'Infections-based-Diabetes Mellitus', 'Fractures, Bone-based-Diabetes Mellitus', 'Diabetes Mellitus-correlated-Nocturia', 'Diabetes Mellitus-correlated-Hypertension', 'Nocturia-correlated-Hypertension', 'Stroke-presented-Kidney Diseases', 'Stroke-caused-Nephrotic Syndrome', 'Nephrotic Syndrome-caused-Hypertension', 'Nephrotic Syndrome-present-Stroke', 'Progeria-include-Neoplasms', 'Tachycardia-describe-Heart Diseases', 'Sarcopenia-include-Endocrine System Diseases', 'Sarcopenia-induce-Endocrine System Diseases', 'Sarcopenia-defined-Chronic Disease', 'Inflammation-induce-Anorexia', 'Inflammation-induce-Sarcopenia', 'Anorexia-induce-Sarcopenia', 'Inflammation-lead-Sarcopenia', 'Cachexia-observed-Neoplasms', 'Cachexia-observed-Heart Failure', 'Cachexia-observed-Liver Cirrhosis', 'Drug-Related Side Effects and Adverse Reactions-determine-Infections', 'Coronary Artery Disease-decrease-Heart Failure', 'Heart Failure-compare-Mitral Valve Insufficiency', 'Hypertension, Pulmonary-decrease-Heart Failure', 'Heart Failure-compare-Dyskinesia, Drug-Induced', 'Atrial Fibrillation-decrease-Heart Failure', 'Retinal Degeneration-cause-Blindness', 'Renal Insufficiency, Chronic-increase-Hip Fractures', 'Atherosclerosis-involve-Inflammation', 'Infections-considered-Death', 'Atherosclerosis-increase-Stroke', 'Obesity-increase-Stroke', 'Diabetes Mellitus-increase-Stroke', 'Hypogonadism-report-Dystonia', 'Death-correspond-Hypertension', 'Headache Disorders, Secondary-associated-Hypogonadism', 'Hypogonadism-associated-Headache Disorders, Secondary', 'Diabetes Mellitus-associated-Neoplasms, Second Primary', 'Neoplasms, Second Primary-associated-Diabetes Mellitus', 'Hypertension-associated-Neoplasms, Second Primary', 'Neoplasms, Second Primary-associated-Hypertension', 'Adenoma-associated-Neoplasms, Second Primary', 'Neoplasms, Second Primary-associated-Adenoma', 'Drug-Related Side Effects and Adverse Reactions-related-Neoplasms', 'Pneumococcal Infections-treat-Infections', 'Pneumococcal Infections-induce-Infections', 'Diabetes Mellitus-label-Hypogonadism', 'Immunologic Deficiency Syndromes-appear-Diabetes Mellitus', 'Immunologic Deficiency Syndromes-associate-Cardiovascular Diseases', 'Cardiovascular Diseases-associate-Immunologic Deficiency Syndromes', 'Immunologic Deficiency Syndromes-associate-Death', 'Death-associate-Immunologic Deficiency Syndromes', 'Apnea-include-Sleep Apnea Syndromes', 'Tuberculosis-correlate-Neoplasms', 'Neoplasms-propose-Hypervitaminosis A', 'Parkinson Disease-propose-Hypervitaminosis A', 'Obesity, Metabolically Benign-include-Hypervitaminosis A', 'Leukoencephalopathies-interpret-Paraneoplastic Syndromes', 'Leukoencephalopathies-interpret-Multiple Myeloma', 'Respiratory Distress Syndrome-show-Tracheal Diseases', 'Constriction, Pathologic-contribute-Respiratory Distress Syndrome', 'Osteoporosis-burden-Death', 'Atherosclerosis-include-Metabolic Diseases', 'Gout-include-Metabolic Diseases', 'Astigmatism-calculated-Corneal Diseases', 'Astigmatism-select-Ocular Hypertension', 'Hemophilia A-direct-Hypertension', 'Hemophilia A-direct-Osteoporosis', 'Wounds and Injuries-play-Cardiovascular Diseases', 'Graft vs Host Disease-exert-Infections', 'Retinoblastoma-include-Neoplasms', 'Neoplasms-pose-Death', 'Glucose Metabolism Disorders-occur-Alzheimer Disease', 'Obesity-submitted-Weight Loss', 'Headache-represent-Nervous System Diseases', 'Arteriovenous Malformations-attributed-Hematologic Diseases', 'Seizures-work-Memory Disorders', 'Nephritis, Interstitial-observed-Aneurysm', 'Glomerulonephritis-represent-Lupus Erythematosus, Systemic', 'Glomerulonephritis-represent-Vasculitis', 'Lupus Erythematosus, Systemic-represent-Vasculitis', 'Cardiovascular Diseases-increased-Death', 'Cardiovascular Diseases-increased-Vasculitis', 'Cardiovascular Diseases-increased-Infections', 'Alzheimer Disease-produce-Wounds and Injuries', 'Alzheimer Disease-produce-Cerebrovascular Trauma', 'Parkinson Disease, Secondary-assessed-Parkinson Disease', 'Hemiplegia-develop-Hemorrhage', 'Disseminated Intravascular Coagulation-lead-Postoperative Hemorrhage', 'Neurodegenerative Diseases-known-Alzheimer Disease', 'Back Pain-amplify-Inflammation', 'Back Pain-amplify-Infections', 'Heart Failure-result-Ventricular Dysfunction', 'Alzheimer Disease-associated-Cataract', 'Cataract-associated-Alzheimer Disease', 'Respiratory Tract Infections-prevent-Pneumonia', 'Hypoglycemia-provide-Diabetes Mellitus', 'Cardiovascular Diseases-estimate-Metabolic Syndrome', 'Death-estimate-Metabolic Syndrome', 'Diabetes Mellitus-highlight-Cardiovascular Diseases', 'Diabetes Mellitus-highlight-Death', 'Metabolic Syndrome-highlight-Cardiovascular Diseases', 'Metabolic Syndrome-highlight-Death', 'Diabetes Mellitus-reported-Stroke', 'Stroke-require-Cerebrovascular Disorders', 'Eye Diseases-analyzed-Dry Eye Syndromes', 'Eye Diseases-analyzed-Glaucoma', 'Eye Diseases-analyzed-Diabetes Mellitus', 'Gallstones-occur-Cholelithiasis', 'Gallstones-transit-Airway Obstruction', 'Stroke-reduce-Nerve Degeneration', 'Pulmonary Disease, Chronic Obstructive-continue-Death', 'Cardiovascular Diseases-continue-Death', 'Hypertension-predispose-Atrial Fibrillation', 'Hypertension-included-Thromboembolism', 'Hypertension-included-Atrial Fibrillation', 'Atrial Fibrillation-increased-Hypertension', 'Stroke-increased-Hypertension', 'Neoplasms-follow-Brain Injuries, Traumatic', 'Neoplasms-include-Brain Injuries, Traumatic', 'Sleep Wake Disorders-explain-Inflammation', 'Heart Valve Diseases-associated-Death', 'Death-associated-Heart Valve Diseases', 'Heart Valve Diseases-associated-Abnormalities, Drug-Induced', 'Abnormalities, Drug-Induced-associated-Heart Valve Diseases', 'Hypothyroidism-include-Autoimmune Diseases', 'Hypoxia-include-Pulmonary Disease, Chronic Obstructive', 'Dyspnea-associated-Pulmonary Disease, Chronic Obstructive', 'Pulmonary Disease, Chronic Obstructive-associated-Dyspnea', 'Pruritus-associated-Mastocytosis, Systemic', 'Mastocytosis, Systemic-associated-Pruritus', 'Dementia-provide-Pain', 'Death-projected-Stomach Neoplasms', 'Stomach Neoplasms-become-Death', 'Muscular Diseases-address-Diabetes Mellitus', 'Muscular Diseases-address-Obesity', 'Neoplasms-cause-Musculoskeletal Diseases', 'Skin Neoplasms-cause-Musculoskeletal Diseases', 'Death-worsen-Heart Failure', 'Hypotension-occur-Pancreatitis', 'Hypotension-occur-Hemorrhage', 'Bradycardia-occur-Pancreatitis', 'Bradycardia-occur-Hemorrhage', 'Hypoxia-occur-Pancreatitis', 'Hypoxia-occur-Hemorrhage', 'Myocardial Infarction-occur-Pancreatitis', 'Cerebral Infarction-occur-Pancreatitis', 'Cerebral Infarction-occur-Hemorrhage', 'Nocturia-classified-Polyuria', 'Diabetes Mellitus, Type 2-show-Atrophy', 'Aneurysm-seen-Stroke, Lacunar', 'Diabetes Mellitus, Type 2-associated-Cerebrovascular Trauma', 'Cerebrovascular Trauma-associated-Diabetes Mellitus, Type 2', 'Constipation-associated-Urinary Incontinence', 'Urinary Incontinence-associated-Constipation', 'Osteoporosis-recognized-Fractures, Bone', 'Hypertension-reported-Atrial Fibrillation', 'Leukoaraiosis-aimed-Death', 'Spinal Cord Injuries-remain-Lung Diseases', 'Lung Diseases-remain-Death', 'Pelvic Neoplasms-carry-Death', 'Death-carry-Hip Fractures', 'Pain-treat-Malnutrition', 'Pain-prevent-Ulcer', 'Pain-reduce-Infections', 'Malnutrition-prevent-Ulcer', 'Malnutrition-reduce-Infections', 'Ulcer-reduce-Infections', 'Venous Thrombosis-presented-Ulcer', 'Venous Thrombosis-surrounded-Pigmentation Disorders', 'Ulcer-surrounded-Pigmentation Disorders', 'Arteriovenous Malformations-base-Leg Ulcer', 'Arteriovenous Malformations-make-Leg Ulcer', 'Ulcer-leave-Pigmentation Disorders', 'Venous Thrombosis-cause-Arteriovenous Malformations', 'Neoplastic Syndromes, Hereditary-include-Pain', 'Neoplastic Syndromes, Hereditary-include-Fractures, Bone', 'Neoplastic Syndromes, Hereditary-include-Hypercalcemia', 'Sensation Disorders-associated-Nervous System Diseases', 'Nervous System Diseases-associated-Sensation Disorders', 'Nervous System Diseases-arise-Pain', 'Nervous System Diseases-contribute-Fibromyalgia', 'Pain-verify-Parkinson Disease', 'Pain-predict-Parkinson Disease', 'Genetic Diseases, Inborn-resolve-Fibrosis', 'Mitochondrial Diseases-trigger-Neurodegenerative Diseases', 'Leukemia-delayed-Multiple Myeloma', 'Death-point-Neoplasms', 'Lung Neoplasms-admitted-Dyspnea', 'Neoplasms-combined-Heart Failure', 'Neoplasms-make-Dyspnea', 'Heart Failure-make-Dyspnea', 'Stroke-discuss-Cerebrovascular Disorders', 'HIV Infections-discuss-Cerebrovascular Disorders', 'Myocardial Infarction-discuss-Cerebrovascular Disorders', 'Memory Disorders-described-Breast Neoplasms', 'Neoplasms-consist-Adenoma', 'Neoplasms-consist-Neoplasm Invasiveness', 'Migraine Disorders-report-Pain', 'Headache-report-Pain', 'Migraine Disorders-consult-Headache', 'Headache-take-Migraine Disorders', 'Colitis, Ischemic-report-Ischemia', 'Diabetes Mellitus-result-Cataract', 'Infections-perform-Labor Pain', 'Neoplasms-referred-Sarcoma', 'Skin Neoplasms-develop-Neoplasms', 'Hypoxia-contribute-Alzheimer Disease', 'Inflammation-prescribed-Polymyalgia Rheumatica', 'Polymyalgia Rheumatica-develop-Uveitis', 'Inflammation-develop-Uveitis', 'Polymyalgia Rheumatica-associated-Scleritis', 'Scleritis-associated-Polymyalgia Rheumatica', 'Polymyalgia Rheumatica-considered-Inflammation', 'Scleritis-considered-Inflammation', 'Constriction, Pathologic-predict-Fistula', 'Periodontitis-recognised-Alzheimer Disease', 'Alzheimer Disease-arise-Headache Disorders, Secondary', 'Immunologic Deficiency Syndromes-include-Neoplasms', 'Death-investigate-Neoplasms', 'Liver Diseases-defined-Fatty Liver', 'Fatty Liver-associated-Albuminuria', 'Albuminuria-associated-Fatty Liver', 'Movement Disorders-revise-Parkinson Disease', 'Aneurysm-include-Alzheimer Disease', 'Metabolic Syndrome-include-Alzheimer Disease', 'Hypertension-deserve-Parkinson Disease', 'Cardiac Output, High-simulate-Hypertension', 'Alzheimer Disease-act-Dementia, Vascular', 'Spinal Cord Injuries-associated-Wounds and Injuries', 'Wounds and Injuries-associated-Spinal Cord Injuries', 'Spinal Cord Injuries-result-Wounds and Injuries', 'Bone Neoplasms-associated-Hip Fractures', 'Hip Fractures-associated-Bone Neoplasms', 'Hip Fractures-treat-Osteoporosis', 'Pneumonia-associated-Chronic Disease', 'Chronic Disease-associated-Pneumonia', 'Mucopolysaccharidosis III-reflect-Parkinson Disease', 'Mucopolysaccharidosis III-differ-Parkinson Disease', 'Leg Injuries-provide-Ulcer', 'Drug-Related Side Effects and Adverse Reactions-lead-Neurodegenerative Diseases', 'Atrial Fibrillation-occur-Cardiac Output, Low', 'Osteoporosis-suffer-Osteoporotic Fractures', 'Fractures, Bone-suffer-Osteoporotic Fractures', 'Sleep Apnea Syndromes-considered-Hypertension', 'Pain-considered-Hypertension', 'Hypoglycemia-considered-Hypertension', 'Pheochromocytoma-considered-Hypertension', 'Blindness-become-Retinal Degeneration', 'Blindness-remain-Cataract', 'Retinal Degeneration-become-Cataract', 'Retinal Degeneration-remain-Cataract', 'Obesity-show-Diabetes Mellitus', 'Laryngitis-follow-Dysphonia', 'Neoplasms-follow-Dysphonia', 'Lymphoproliferative Disorders-include-Epstein-Barr Virus Infections', 'Ulcer-include-Epstein-Barr Virus Infections', 'Immunologic Deficiency Syndromes-include-Epstein-Barr Virus Infections', 'Immunologic Deficiency Syndromes-associated-Epstein-Barr Virus Infections', 'Epstein-Barr Virus Infections-associated-Immunologic Deficiency Syndromes', 'Lung Neoplasms-lead-Airway Obstruction', 'Lung Neoplasms-lead-Hemorrhage', 'Cerebrovascular Disorders-use-Leukoencephalopathies', 'Cerebrovascular Disorders-use-Alzheimer Disease', 'Leukoencephalopathies-use-Alzheimer Disease', 'Cerebrovascular Disorders-affected-Alzheimer Disease', 'Brain Diseases-affected-Alzheimer Disease', 'Adrenal Insufficiency-incorporate-Death', 'Diabetes Mellitus-investigate-Brain Diseases', 'Diabetes Mellitus-measured-Brain Diseases', 'Glucose Metabolism Disorders-correlate-Headache Disorders, Secondary', 'Glucose Metabolism Disorders-correlate-Dementia', 'Glucose Metabolism Disorders-explain-Alzheimer Disease', 'Glucose Metabolism Disorders-explain-Diabetes Mellitus', 'Glucose Metabolism Disorders-detect-Alzheimer Disease', 'Obesity-compromise-Inflammation', 'Dementia-represented-Alzheimer Disease', 'Malnutrition-associated-Dementia', 'Dementia-associated-Malnutrition', 'Immunologic Deficiency Syndromes-result-Neoplasms', 'Diabetes Mellitus-include-Cataract', 'Brain Diseases-caused-Brain Ischemia', 'Inflammation-increase-Brain Ischemia', 'Inflammation-confirm-Brain Injuries', 'Brain Ischemia-confirm-Brain Injuries', 'Intellectual Disability-associated-Death, Sudden, Cardiac', 'Death, Sudden, Cardiac-associated-Intellectual Disability', 'Proteinuria-increase-Kidney Failure, Chronic', 'Kidney Failure, Chronic-prevail-Death', 'Dementia-referred-Memory Disorders', 'Erectile Dysfunction-associated-Prostatic Hyperplasia', 'Prostatic Hyperplasia-associated-Erectile Dysfunction', 'Erectile Dysfunction-associated-Glomerulonephritis', 'Glomerulonephritis-associated-Erectile Dysfunction', 'Erectile Dysfunction-associated-Kidney Failure, Chronic', 'Kidney Failure, Chronic-associated-Erectile Dysfunction', 'Neoplasms-include-Lung Neoplasms', 'Neoplasms-include-Carcinoma, Hepatocellular', 'Death-include-Colorectal Neoplasms', 'Death-include-Carcinoma, Hepatocellular', 'Death-include-Breast Neoplasms', 'Arteriovenous Malformations-associated-Death', 'Death-associated-Arteriovenous Malformations', 'Dyslipidemias-associated-Hypotension', 'Hypotension-associated-Dyslipidemias', 'Death-use-Arteriovenous Malformations', 'Death-use-Fistula', 'Neoplasms-cause-Liver Failure', 'Neoplasms-include-Cholangitis, Sclerosing', 'Liver Diseases, Alcoholic-include-Neoplasms', 'Lupus Erythematosus, Systemic-complicate-Aortic Aneurysm', 'Deglutition Disorders-referred-Growth Disorders', 'Deglutition Disorders-associated-Growth Disorders', 'Growth Disorders-associated-Deglutition Disorders', 'Deglutition Disorders-referred-Hypertension', 'Deglutition Disorders-associated-Hypertension', 'Hypertension-associated-Deglutition Disorders', 'Deglutition Disorders-referred-Kyphosis', 'Deglutition Disorders-associated-Kyphosis', 'Kyphosis-associated-Deglutition Disorders', 'Aortic Aneurysm, Thoracic-referred-Deglutition Disorders', 'Aortic Aneurysm, Thoracic-referred-Growth Disorders', 'Aortic Aneurysm, Thoracic-referred-Hypertension', 'Aortic Aneurysm, Thoracic-referred-Kyphosis', 'Osteoporosis-result-Renal Insufficiency, Chronic', 'Renal Insufficiency, Chronic-increase-Fractures, Bone', 'Osteoporosis-underlie-Chronic Kidney Disease-Mineral and Bone Disorder', 'Renal Insufficiency, Chronic-underlie-Chronic Kidney Disease-Mineral and Bone Disorder', 'Inflammation-review-Metabolic Syndrome', 'Hemangioblastoma-included-Gait Ataxia', 'Hemangioblastoma-present-Gait Ataxia', 'Death-suggest-Chronic Disease', 'Osteoma, Osteoid-suggest-Neurologic Manifestations', 'Peripheral Vascular Diseases-associated-Dyslipidemias', 'Dyslipidemias-associated-Peripheral Vascular Diseases', 'Peripheral Vascular Diseases-followed-Dyslipidemias', 'Peripheral Vascular Diseases-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-Peripheral Vascular Diseases', 'Peripheral Vascular Diseases-followed-Diabetes Mellitus', 'Pyelonephritis-identify-Death', 'Respiratory Tract Infections-identify-Death', 'Disseminated Intravascular Coagulation-associated-Death', 'Death-associated-Disseminated Intravascular Coagulation', 'Kidney Diseases-develop-Shock', 'Diabetes Mellitus-develop-Shock', 'Shock-demonstrate-Airway Obstruction', 'Pain-improve-Dementia', 'Pain-tailored-Dementia', 'Postoperative Cognitive Complications-enter-Dementia', 'Postoperative Cognitive Complications-include-Aneurysm', 'Postoperative Cognitive Complications-include-Alcoholism', 'Leukemia, Lymphocytic, Chronic, B-Cell-include-Neoplasms', 'Infections-undergo-Retinal Degeneration', 'Retinal Degeneration-cause-Death', 'Retinal Degeneration-cause-Arbovirus Infections', 'Hypoplastic Left Heart Syndrome-develop-Aortic Valve Insufficiency', 'Neurologic Manifestations-show-Infarction', 'Arthritis, Rheumatoid-mimic-Polymyalgia Rheumatica', 'Obesity-contribute-Death', 'Death-survive-Obesity', 'Death-survive-Fractures, Bone', 'Obesity-survive-Fractures, Bone', 'Sarcopenia-indicated-Ataxia', 'Ataxia-defined-Obesity', 'REM Sleep Behavior Disorder-foreshadow-Neurodegenerative Diseases', 'REM Sleep Behavior Disorder-precede-Parkinson Disease, Secondary', 'Neurodegenerative Diseases-foreshadow-Parkinson Disease', 'REM Sleep Behavior Disorder-associated-Dementia', 'Dementia-associated-REM Sleep Behavior Disorder', 'REM Sleep Behavior Disorder-associated-Parkinson Disease', 'Parkinson Disease-associated-REM Sleep Behavior Disorder', 'Tremor-fall-Nervous System Diseases', 'Tremor-associated-REM Sleep Behavior Disorder', 'REM Sleep Behavior Disorder-associated-Tremor', 'Parkinson Disease, Secondary-fall-Nervous System Diseases', 'Parkinson Disease, Secondary-associated-REM Sleep Behavior Disorder', 'REM Sleep Behavior Disorder-associated-Parkinson Disease, Secondary', 'Nervous System Diseases-associated-REM Sleep Behavior Disorder', 'REM Sleep Behavior Disorder-associated-Nervous System Diseases', 'Nervous System Diseases-associated-Parkinson Disease', 'Parkinson Disease-associated-Nervous System Diseases', 'Neurodegenerative Diseases-associated-REM Sleep Behavior Disorder', 'REM Sleep Behavior Disorder-associated-Neurodegenerative Diseases', 'Alzheimer Disease-exhibit-Dementia, Vascular', 'Alzheimer Disease-exhibit-Dementia', 'Hypogonadism-contribute-Cardiovascular Diseases', 'Deglutition Disorders-associated-Candidiasis', 'Candidiasis-associated-Deglutition Disorders', 'Deglutition Disorders-related-Adrenal Insufficiency', 'Stroke-reveal-Death', 'Heart Diseases-reveal-Death', 'Delirium-associated-Sensation Disorders', 'Sensation Disorders-associated-Delirium', 'Immunologic Deficiency Syndromes-associated-Atrial Fibrillation', 'Atrial Fibrillation-associated-Immunologic Deficiency Syndromes', 'Renal Insufficiency, Chronic-combined-Albuminuria', 'Albuminuria-combined-Renal Insufficiency, Chronic', 'Psoriasis-evaluated-Erectile Dysfunction', 'Metabolic Syndrome-found-Erectile Dysfunction', 'Atrophy-recognized-Alzheimer Disease', 'Dementia-contribute-Stroke', 'Stomach Neoplasms-detect-Neoplasms', 'Diabetes Mellitus-found-Coronary Artery Disease', 'Alzheimer Disease-reduce-Headache Disorders, Secondary', 'Alzheimer Disease-limited-Headache Disorders, Secondary', 'Inflammation-treat-Asthma', 'Death-expressed-Cardiovascular Diseases', 'Kidney Diseases-related-Drug-Related Side Effects and Adverse Reactions', 'Death-underlie-Sepsis', 'Metabolic Syndrome-demonstrated-Stomach Neoplasms', 'Obesity, Abdominal-increase-Hip Fractures', 'Cardiac Output, Low-associated-Heart Failure', 'Heart Failure-associated-Cardiac Output, Low', 'Obesity-suffer-Osteoporotic Fractures', 'Glioblastoma-reflect-Neoplasms', 'Lung Diseases, Interstitial-compute-Lung Neoplasms', 'Delirium-detected-Dementia', 'Delirium-operate-Dementia', 'Osteoporosis-lead-Pseudarthrosis', 'Scoliosis-undergo-Neural Tube Defects', 'Chronic Disease-become-Neurotoxicity Syndromes', 'Death-associated-Gout', 'Gout-associated-Death', 'Metabolic Syndrome-benefit-Atherosclerosis', 'Hyperglycemia-benefit-Atherosclerosis', 'Infections-include-Lung Diseases', 'Pain-live-Weight Loss', 'Chronic Disease-experience-Atherosclerosis', 'Renal Insufficiency, Chronic-identify-Death', 'Arthritis, Rheumatoid-experience-Atherosclerosis', 'Death-correlate-Constipation', 'Lupus Erythematosus, Systemic-experience-Atherosclerosis', 'Heart Failure-develop-Coronary Artery Disease', 'Alzheimer Disease-treated-Ventricular Dysfunction', 'Alzheimer Disease-prevent-Ventricular Dysfunction', 'Neurodegenerative Diseases-involve-Headache Disorders, Secondary', 'Headache Disorders, Secondary-involve-Alzheimer Disease', 'Chronic Pain-associated-Arthritis, Rheumatoid', 'Arthritis, Rheumatoid-associated-Chronic Pain', 'Pneumococcal Infections-cause-Death', 'Osteoarthritis-follow-Gout', 'Osteoarthritis-follow-Arthritis, Rheumatoid', 'Supranuclear Palsy, Progressive-proposed-Parkinson Disease, Secondary', 'Parkinson Disease-proposed-Parkinson Disease, Secondary', 'Pneumococcal Infections-license-Pneumonia', 'Pneumococcal Infections-license-Neoplasm Invasiveness', 'Glomerulonephritis-suspected-Fever', 'Death-caused-Myocardial Infarction', 'Chronic Disease-associated-Neoplasm Metastasis', 'Neoplasm Metastasis-associated-Chronic Disease', 'Pneumococcal Infections-cause-Pneumonia', 'Pneumococcal Infections-cause-Bacteremia', 'Pneumococcal Infections-cause-Meningitis', 'Pain-impair-Musculoskeletal Diseases', 'Death-compare-Wounds and Injuries', 'Death-cause-Hemorrhage', 'Stroke-reduce-Intracranial Hemorrhages', 'Death-associate-Hemorrhage', 'Hemorrhage-associate-Death', 'Death-reduce-Intracranial Hemorrhages', 'Hemorrhage-associated-Fractures, Bone', 'Fractures, Bone-associated-Hemorrhage', 'Hemorrhage-occur-Fractures, Bone', 'Atherosclerosis-penetrate-Ulcer', 'Ulcer-penetrate-Hematoma', 'Ulcer-cause-Hematoma', 'Atherosclerosis-cause-Hematoma', 'Death-caused-Stroke', 'Pneumonia-use-Infections', 'Anemia-associated-Stroke', 'Stroke-associated-Anemia', 'Delirium-induce-Inflammation', 'Inflammation-lead-Delirium', 'Renal Insufficiency, Chronic-evaluated-Thromboembolism', 'Renal Insufficiency, Chronic-evaluated-Death', 'Fractures, Bone-assess-Cardiovascular Diseases', 'Cardiovascular Diseases-assess-Diabetes Mellitus', 'Fractures, Bone-assess-Diabetes Mellitus', 'Renal Insufficiency-treat-Hyperlipidemias', 'Death-observed-Wounds and Injuries', 'Brain Injuries, Traumatic-experience-Death', 'Wounds and Injuries-minimize-Stroke', 'Wounds and Injuries-face-Craniocerebral Trauma', 'Wounds and Injuries-avoid-Intracranial Hemorrhages', 'Stroke-avoid-Intracranial Hemorrhages', 'Craniocerebral Trauma-avoid-Intracranial Hemorrhages', 'Stroke-include-Craniocerebral Trauma', 'Craniocerebral Trauma-exceed-Stroke', 'Osteophyte-lead-Signs and Symptoms, Respiratory', 'Pain-pass-Infections', 'Death-present-Gastrointestinal Hemorrhage', 'Death-follow-Anastomotic Leak', 'Ischemia-induce-Neurologic Manifestations', 'Brain Ischemia-induced-Arterial Occlusive Diseases', 'Dementia-associated-Cerebral Infarction', 'Cerebral Infarction-associated-Dementia', 'Seizures-fit-Death', 'Metabolic Syndrome-linked-Dementia', 'Musculoskeletal Diseases-assess-Inflammation', 'Sarcopenia-described-Chronic Disease', 'Diabetes Mellitus-related-Hypertension', 'Diabetes Mellitus-related-Hypercholesterolemia', 'Diabetes Mellitus-related-Renal Insufficiency', 'Parental Death-associated-Death', 'Death-associated-Parental Death', 'Inflammation-link-Alzheimer Disease', 'Alzheimer Disease-established-Diabetes Mellitus', 'Death-become-Brain Injuries, Traumatic', 'Death-outpace-Brain Injuries, Traumatic', 'Metabolic Diseases-established-Diabetes Mellitus', 'Brain Injuries, Traumatic-term-Neurodegenerative Diseases', 'Brain Injuries, Traumatic-manifest-Neurologic Manifestations', 'Stroke-used-Cerebral Infarction', 'Postpartum Hemorrhage-associated-Pneumonia', 'Pneumonia-associated-Postpartum Hemorrhage', 'Atrial Fibrillation-associated-Sick Sinus Syndrome', 'Sick Sinus Syndrome-associated-Atrial Fibrillation', 'Alzheimer Disease-protect-Death', 'Dehydration-compounded-Deglutition Disorders', 'Dementia-suffer-Hypotension, Orthostatic', 'Osteoporosis-confer-Death', 'Mouth Diseases-cause-Death', 'Zoonoses-cause-Death', 'Cataract-contribute-Blindness', 'Death-underlie-Encephalitis', 'Hypoglycemia-associate-Kidney Diseases', 'Kidney Diseases-associate-Hypoglycemia', 'Diabetes Mellitus-contribute-Neoplasms', 'Albuminuria-associate-Death', 'Death-associate-Albuminuria', 'Kidney Diseases-confirm-Diabetes Mellitus', 'HIV Infections-associated-Nervous System Diseases', 'Nervous System Diseases-associated-HIV Infections', 'HIV Infections-lead-Neurodegenerative Diseases', 'Dementia-associated-HIV Infections', 'HIV Infections-associated-Dementia', 'Neurodegenerative Diseases-associated-AIDS Arteritis, Central Nervous System', 'AIDS Arteritis, Central Nervous System-associated-Neurodegenerative Diseases', 'Thrombocytopenia-define-Death', 'Thrombocytosis-define-Death', 'Osteosarcoma-resemble-Lymphoma, B-Cell', 'Thrombocytosis-compare-Death', 'Cardiomyopathy, Hypertrophic-include-Death', 'Atrial Fibrillation-include-Chagas Disease', 'Myocardial Infarction-include-Chagas Disease', 'Cardiomyopathy, Hypertrophic-include-Chagas Disease', 'Hypoxia-predict-Sleep Initiation and Maintenance Disorders', 'Cardiovascular Diseases-collected-Death', 'Cardiovascular Diseases-associated-Hypoxia', 'Hypoxia-associated-Cardiovascular Diseases', 'Hypoxia-cause-Sleep Initiation and Maintenance Disorders', 'Cardiovascular Diseases-follow-Sleep Initiation and Maintenance Disorders', 'Hypoxia-follow-Sleep Initiation and Maintenance Disorders', 'Death-follow-Sleep Initiation and Maintenance Disorders', 'Graft vs Host Disease-include-Death', 'Death-increase-Myelodysplastic Syndromes', 'Dementia-include-Inflammation', 'Dementia-affected-Inflammation', 'CADASIL-investigate-Porencephaly', 'Infarction-investigate-Porencephaly', 'Leukoencephalopathies-investigate-Porencephaly', 'Bone Neoplasms-result-Osteoporosis', 'Bone Neoplasms-share-Osteoporosis', 'Spinal Cord Injuries-suffer-Bone Neoplasms', 'Fractures, Bone-differ-Spinal Cord Injuries', 'Spinal Cord Injuries-include-Musculoskeletal Diseases', 'Multiple Sclerosis-include-Musculoskeletal Diseases', 'Gastroesophageal Reflux-present-Mucositis', 'Common Cold-present-Mucositis', 'Hypogonadism-admitted-Acute Disease', 'Kidney Failure, Chronic-decrease-Diabetes Mellitus', 'Kidney Failure, Chronic-decrease-Diabetes Mellitus, Type 2', 'Hemorrhage-determine-Stroke', 'Scleroderma, Systemic-suggest-Genetic Diseases, Inborn', 'Inflammation-underlie-Uremia', 'Weight Loss-lead-Death', 'Delirium-fall-Death', 'Epilepsy-gain-Seizures', 'Nocturia-cause-Hyponatremia', 'Fractures, Bone-used-Postpartum Hemorrhage', 'Neurodegenerative Diseases-remove-Blood Protein Disorders', 'Muscular Diseases-occur-Heart Failure', 'Muscular Diseases-occur-Pulmonary Disease, Chronic Obstructive', 'Muscular Diseases-occur-End Stage Liver Disease', 'Muscular Diseases-occur-Kidney Failure, Chronic', 'Cachexia-defined-Hereditary Breast and Ovarian Cancer Syndrome', 'Cachexia-associated-Anorexia', 'Anorexia-associated-Cachexia', 'Cachexia-associated-Weight Loss', 'Weight Loss-associated-Cachexia', 'Hereditary Breast and Ovarian Cancer Syndrome-associated-Anorexia', 'Anorexia-associated-Hereditary Breast and Ovarian Cancer Syndrome', 'Hereditary Breast and Ovarian Cancer Syndrome-associated-Weight Loss', 'Weight Loss-associated-Hereditary Breast and Ovarian Cancer Syndrome', 'Inflammation-associate-Renal Insufficiency, Chronic', 'Renal Insufficiency, Chronic-associate-Inflammation', 'Renal Insufficiency, Chronic-associate-Cardiovascular Diseases', 'Cardiovascular Diseases-associate-Renal Insufficiency, Chronic', 'Neoplasms-occur-Neuroma, Acoustic', 'Neoplasms-occur-Hodgkin Disease', 'Neurilemmoma-resected-Neoplasms', 'Neoplasms-base-Meningeal Neoplasms', 'Dementia-associated-Enuresis', 'Enuresis-associated-Dementia', 'Death-found-Shock', 'Endocrine System Diseases-associated-Sarcopenia', 'Sarcopenia-associated-Endocrine System Diseases', 'Neoplasms-assigned-Breast Neoplasms', 'Inflammation-target-Joint Diseases', 'Critical Illness-tend-Death', 'Critical Illness-result-Death', 'Inflammation-predicted-Neoplasms', 'Inflammation-related-Dementia', 'Infections-respond-Sepsis', 'Hypertension-include-Drug-Related Side Effects and Adverse Reactions', 'Thromboembolism-include-Drug-Related Side Effects and Adverse Reactions', 'Nervous System Diseases-function-Death', 'Death-increased-Stroke', 'Hypertension, Pulmonary-initiate-Pulmonary Arterial Hypertension', 'Obesity-increase-Hyperplasia', 'Obesity-increase-Hypertrophy', 'Obesity-keep-Hyperplasia', 'Obesity-keep-Hypertrophy', 'Diabetes Mellitus-keep-Hyperplasia', 'Diabetes Mellitus-keep-Hypertrophy', 'Renal Insufficiency, Chronic-progress-Kidney Diseases', 'Diabetes Mellitus-experience-Constriction, Pathologic', 'Neurodegenerative Diseases-provide-Cardiovascular Abnormalities', 'Neurodegenerative Diseases-provide-Postoperative Cognitive Complications', 'Leukoencephalopathies-identify-Postoperative Cognitive Complications', 'Cerebral Infarction-identify-Postoperative Cognitive Complications', 'Breast Neoplasms-involve-Drug-Related Side Effects and Adverse Reactions', 'Low Back Pain-coupled-Osteoarthritis', 'Pain-coupled-Osteoarthritis', 'Fecal Incontinence-characterized-Diarrhea', 'Urinary Incontinence-associated-Diarrhea', 'Diarrhea-associated-Urinary Incontinence', 'Urinary Incontinence-characterized-Stroke', 'Urinary Incontinence-characterized-Constipation', 'Urinary Incontinence-characterized-Diarrhea', 'Brain Injuries, Traumatic-investigate-Death', 'Hypertension-associated-Peripheral Arterial Disease', 'Peripheral Arterial Disease-associated-Hypertension', 'Neurodegenerative Diseases-present-Cerebral Hemorrhage', 'Hyperlipidemias-make-Nervous System Diseases', 'Migraine Disorders-reduce-Alzheimer Disease', 'Stomach Diseases-differ-Infections', 'Fractures, Bone-result-Neoplasms', 'Meningitis, Bacterial-induce-Prostatitis', 'Meningitis, Bacterial-induce-Hypercholesterolemia', 'Arbovirus Infections-induce-Prostatitis', 'Arbovirus Infections-induce-Hypercholesterolemia', 'Fractures, Bone-induced-Neoplasms', 'Immunologic Deficiency Syndromes-result-Hearing Loss', 'Immunologic Deficiency Syndromes-result-Arrhythmias, Cardiac', 'Pain-improve-Arthritis', 'Diabetes Mellitus-recognize-Carotid Artery Diseases', 'Hyperpigmentation-observed-Nephrosis, Lipoid', 'Parkinson Disease, Secondary-assess-Parkinson Disease', 'Endocarditis-associate-Colorectal Neoplasms', 'Colorectal Neoplasms-associate-Endocarditis', 'Hip Fractures-include-Pelvic Neoplasms', 'Neoplasms-need-Acquired Immunodeficiency Syndrome', 'Amnesia-develop-Alzheimer Disease', 'Neurodegenerative Diseases-spared-Memory Disorders', 'Stroke-associated-Peripheral Vascular Diseases', 'Peripheral Vascular Diseases-associated-Stroke', 'Peripheral Vascular Diseases-associated-Hypotension, Orthostatic', 'Hypotension, Orthostatic-associated-Peripheral Vascular Diseases', 'Vascular Calcification-compared-Renal Insufficiency, Chronic', 'Acute Kidney Injury-increasing-Acute Disease', 'Aortic Diseases-used-Heart Valve Diseases', 'Sarcoma-treat-Neoplasms', 'Sarcoma-increase-Neoplasms', 'Myocardial Infarction-associated-Dementia', 'Dementia-associated-Myocardial Infarction', 'Sarcoma-treat-Rupture', 'Sarcoma-constrain-Rupture', 'Sarcoma-treat-Pain', 'Sarcoma-treat-Infections', 'Sarcoma-treat-Hemorrhage', 'Ulcer-treat-Neoplasms', 'Ulcer-treat-Rupture', 'Ulcer-treat-Pain', 'Ulcer-treat-Infections', 'Ulcer-treat-Hemorrhage', 'Kidney Failure, Chronic-include-Diabetes Mellitus', 'Neoplasms-constrain-Pain', 'Atrophy-linked-Reperfusion Injury', 'Neoplasms-constrain-Infections', 'Rupture-constrain-Pain', 'Rupture-constrain-Infections', 'Asthma-diagnosed-Pulmonary Disease, Chronic Obstructive', 'Drug Hypersensitivity-include-Asthma', 'Cartilage Diseases-degenerate-Necrosis', 'Mitochondrial Diseases-augmented-Alzheimer Disease', 'Cytomegalovirus Infections-contribute-Inflammation', 'Hodgkin Disease-show-Epstein-Barr Virus Infections', 'Hodgkin Disease-distinguish-Inflammatory Bowel Diseases', 'Lymphoproliferative Disorders-distinguish-Inflammatory Bowel Diseases', 'Myoclonus-defined-Dyskinesias', 'Myoclonus-defined-Nervous System Diseases', 'Lymphoma-mimic-Pityriasis', 'Infections-cause-Lymphoproliferative Disorders', 'Hydroa Vacciniforme-develop-Lymphoproliferative Disorders', 'Infections-complicated-Lymphohistiocytosis, Hemophagocytic', 'Infections-complicated-Lymphoproliferative Disorders', 'Infections-include-Lymphoproliferative Disorders', 'Drug Hypersensitivity-include-Lymphoproliferative Disorders', 'Diabetes Mellitus, Type 2-associated-Communicable Diseases', 'Communicable Diseases-associated-Diabetes Mellitus, Type 2', 'Hematoma-associated-Cerebral Hemorrhage', 'Cerebral Hemorrhage-associated-Hematoma', 'Cerebral Hemorrhage-increase-Hypertension', 'Atherosclerosis-associated-Hyperlipidemias', 'Hyperlipidemias-associated-Atherosclerosis', 'Death-occur-Atrial Fibrillation', 'Hypertriglyceridemia-associated-Carcinoma, Hepatocellular', 'Carcinoma, Hepatocellular-associated-Hypertriglyceridemia', 'Hypertriglyceridemia-associated-Death', 'Death-associated-Hypertriglyceridemia', 'Hypercholesterolemia-associated-Carcinoma, Hepatocellular', 'Carcinoma, Hepatocellular-associated-Hypercholesterolemia', 'Metabolic Syndrome-associated-Carcinoma, Hepatocellular', 'Carcinoma, Hepatocellular-associated-Metabolic Syndrome', 'Dyslipidemias-relate-Carcinoma, Hepatocellular', 'Dyslipidemias-relate-Death', 'Dementia-review-Wounds and Injuries', 'Death-acquire-Neoplasms', 'Neoplasm Metastasis-acquire-Death', 'Myelodysplastic Syndromes-mark-Leukemia, Myeloid, Acute', 'Ischemia-included-Stroke', 'Ischemia-included-Cerebral Hemorrhage', 'Adrenal Insufficiency-decrease-Death', 'Neurotoxicity Syndromes-addressed-Alzheimer Disease', 'Dementia-experience-Alzheimer Disease', 'Renal Insufficiency, Chronic-mask-Proteinuria', 'Renal Insufficiency, Chronic-mask-Cardiovascular Diseases', 'Renal Insufficiency, Chronic-include-Hypoalbuminemia', 'Renal Insufficiency, Chronic-include-Proteinuria', 'Hypoalbuminemia-associated-Proteinuria', 'Proteinuria-associated-Hypoalbuminemia', 'Acute Coronary Syndrome-cause-Death', 'Neoplasms-assessed-Amyloidosis', 'Immunoglobulin Light-chain Amyloidosis-associated-Multiple Myeloma', 'Multiple Myeloma-associated-Immunoglobulin Light-chain Amyloidosis', 'Neoplasms-use-Amyloidosis', 'Multiple Myeloma-associated-Amyloidosis, Familial', 'Amyloidosis, Familial-associated-Multiple Myeloma', 'Multiple Myeloma-associated-Lymphoma, Non-Hodgkin', 'Lymphoma, Non-Hodgkin-associated-Multiple Myeloma', 'Amyloidosis, Familial-related-Lymphoma, Non-Hodgkin', 'Skin Neoplasms-diagnosed-Lymphoma, Non-Hodgkin', 'Multiple Myeloma-suggest-Immunoglobulin Light-chain Amyloidosis', 'Multiple Myeloma-receive-Arthritis, Rheumatoid', 'Multiple Myeloma-suggest-Amyloidosis', 'Infections-associated-Inflammatory Bowel Diseases', 'Inflammatory Bowel Diseases-associated-Infections', 'Infections-account-Inflammatory Bowel Diseases', 'Inflammatory Bowel Diseases-confused-Diverticular Diseases', 'Inflammatory Bowel Diseases-confused-Colitis, Ischemic', 'Glucose Metabolism Disorders-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-Glucose Metabolism Disorders', 'Infections-eliminate-Death', 'Infections-rival-Death', 'Infections-live-Neoplasms', 'Infections-rival-Melanoma', 'Werner Syndrome-shown-Neoplasms', 'Werner Syndrome-shown-Cardiovascular Diseases', 'Brugada Syndrome-experience-Arrhythmias, Cardiac', 'Pain-include-Acute Pain', 'Acute Pain-associated-Chronic Pain', 'Chronic Pain-associated-Acute Pain', 'Acute Pain-associated-Pain', 'Pain-associated-Acute Pain', 'Inflammation-prevent-Cerebral Small Vessel Diseases', 'Movement Disorders-linked-Paraneoplastic Syndromes', 'Epilepsy, Temporal Lobe-diagnosed-Paraneoplastic Syndromes', 'Epilepsy, Temporal Lobe-diagnosed-Colonic Neoplasms', 'Psychoses, Substance-Induced-diagnosed-Paraneoplastic Syndromes', 'Psychoses, Substance-Induced-diagnosed-Colonic Neoplasms', 'Neoplasms-related-Paraneoplastic Syndromes, Nervous System', 'Sarcopenia-associated-Gout', 'Gout-associated-Sarcopenia', 'Sleep Wake Disorders-measure-Sleep Initiation and Maintenance Disorders', 'Embolism-lead-Death', 'Organophosphate Poisoning-produce-Drug-Related Side Effects and Adverse Reactions', 'Nervous System Diseases-produce-Drug-Related Side Effects and Adverse Reactions', 'Tuberculosis-treated-Lung Diseases', 'Lung Diseases-hospitalize-Tuberculosis', 'Dementia-involve-Neurodegenerative Diseases', 'Alzheimer Disease-appear-Neurodegenerative Diseases', 'Parkinson Disease-associated-Neurobehavioral Manifestations', 'Neurobehavioral Manifestations-associated-Parkinson Disease', 'Nerve Degeneration-associated-Parkinson Disease', 'Parkinson Disease-associated-Nerve Degeneration', 'Dry Eye Syndromes-observe-Corneal Diseases', 'Dry Eye Syndromes-transfer-Immunologic Deficiency Syndromes', 'Parkinson Disease-display-Tremor', 'Parkinson Disease-display-Muscle Rigidity', 'Parkinson Disease-display-Hypokinesia', 'Osteoporosis-expected-Fractures, Bone', 'Death-classified-Tuberculosis', 'Tuberculosis-classified-Death', 'Tuberculosis-base-Death', 'Liver Cirrhosis-contribute-Death', 'Death-prevent-Shock, Septic', 'Hereditary Breast and Ovarian Cancer Syndrome-characterised-Fatigue', 'Hereditary Breast and Ovarian Cancer Syndrome-characterised-Erectile Dysfunction', 'Hereditary Breast and Ovarian Cancer Syndrome-characterised-Osteoporosis', 'Urinary Bladder Neoplasms-use-Neoplasms', 'Neoplasms-highlight-Urinary Bladder Neoplasms', 'Hereditary Breast and Ovarian Cancer Syndrome-characterized-Fat Necrosis', 'Fat Necrosis-characterized-Diabetes Mellitus', 'Fat Necrosis-associated-Dyslipidemias', 'Dyslipidemias-associated-Fat Necrosis', 'Fat Necrosis-characterized-Dyslipidemias', 'Fat Necrosis-comprise-Non-alcoholic Fatty Liver Disease', 'Lesch-Nyhan Syndrome-show-Leukoencephalopathies', 'Eosinophilia-account-Chronic Disease', 'Brain Injuries, Traumatic-aggravate-Death', 'Eosinophilia-distinguish-Asthma', 'Chronic Disease-distinguish-Asthma', 'Neoplasms-investigate-Stroke', 'Neoplasms-investigate-Dementia', 'Pulmonary Disease, Chronic Obstructive-pressurize-Hypertension', 'Stroke-associated-Angina Pectoris', 'Angina Pectoris-associated-Stroke', 'Stroke-associated-Hearing Loss', 'Hearing Loss-associated-Stroke', 'Angina Pectoris-hear-Hearing Loss', 'Hearing Loss-hear-Stroke', 'Hearing Loss-hear-Pain', 'Wounds and Injuries-associated-Cerebrovascular Disorders', 'Cerebrovascular Disorders-associated-Wounds and Injuries', 'Sleep Initiation and Maintenance Disorders-work-Stroke', 'Pain-affected-Bursitis', 'Mitochondrial Diseases-implicated-Stroke', 'Mitochondrial Diseases-implicated-Alzheimer Disease', 'Wounds and Injuries-defined-Brain Injuries', 'Wounds and Injuries-defined-Unconsciousness', 'Brain Injuries-defined-Unconsciousness', 'Mitochondrial Diseases-implicated-Muscular Atrophy', 'Gastrointestinal Diseases-carried-Colonic Neoplasms', 'Pneumococcal Infections-carried-Colonic Neoplasms', 'End Stage Liver Disease-defined-Diabetes Mellitus', 'Dementia-developed-Pneumonia', 'Alcohol Amnestic Disorder-represent-Dementia', 'Dementia-experience-Alcohol Amnestic Disorder', 'Ulcer-consider-Peripheral Arterial Disease', 'Sotos Syndrome-result-Nerve Degeneration', 'Death-defined-Diabetes Mellitus', 'Central Nervous System Infections-account-Death', 'Malabsorption Syndromes-seen-Anemia', 'Tuberculosis-account-Death', 'Fever-include-Meningitis, Bacterial', 'Headache-include-Meningitis, Bacterial', 'Meningism-include-Meningitis, Bacterial', 'Meningococcal Infections-include-Meningitis, Bacterial', 'Heart Failure-backed-Hypotension', 'Arthritis-include-Metabolic Diseases', 'Communicable Diseases-include-Metabolic Diseases', 'Heart Failure, Diastolic-associated-Death', 'Death-associated-Heart Failure, Diastolic', 'Heart Failure, Diastolic-associated-Heart Failure', 'Heart Failure-associated-Heart Failure, Diastolic', 'Heart Failure, Diastolic-associated-Heart Diseases', 'Heart Diseases-associated-Heart Failure, Diastolic', 'Infections-prevent-Respiratory Syncytial Virus Infections', 'Respiratory Insufficiency-include-Pneumonia', 'Sepsis-include-Pneumonia', 'Periodontal Diseases-defined-Alveolar Bone Loss', 'Periodontal Diseases-exhibit-Alveolar Bone Loss', 'Infections-promote-Periodontal Diseases', 'Diabetes Mellitus-suffer-Erectile Dysfunction', 'Autoimmune Diseases-report-Arthritis, Rheumatoid', 'Arthritis, Rheumatoid-related-Periodontal Diseases', 'Myalgia-lead-Weight Loss', 'Diarrhea-lead-Weight Loss', 'Craniocerebral Trauma-admitted-Wounds and Injuries', 'Learning Disabilities-occur-Alzheimer Disease', 'Appendicitis-develop-Necrosis', 'Myelodysplastic Syndromes-associated-Bone Marrow Diseases', 'Bone Marrow Diseases-associated-Myelodysplastic Syndromes', 'Hematologic Neoplasms-occur-Myelodysplastic Syndromes', 'Myelodysplastic Syndromes-occur-Bone Marrow Failure Disorders', 'Death-switch-Infections', 'Neoplasms-progress-Respiratory Insufficiency', 'Hydrocephalus-attributed-Neurodegenerative Diseases', 'Gliosis-associated-Hydrocephalus', 'Hydrocephalus-associated-Gliosis', 'Diabetes Mellitus-accompanied-Dyslipidemias', 'Hypotension-accompanied-Dyslipidemias', 'Dyslipidemias-accompanied-Atherosclerosis', 'Cerebral Infarction-confirmed-Thrombosis', 'Cerebral Infarction-confirmed-Embolism', 'Cerebral Infarction-confirmed-Hemorrhage', 'Cerebral Infarction-confirmed-Subarachnoid Hemorrhage', 'Cerebral Infarction-confirmed-Cerebral Hemorrhage', 'Atherosclerosis-prevent-Stroke', 'Diabetes Mellitus-smoking-Dyslipidemias', 'Melanoma-reveal-Neoplasms', 'Sleep Wake Disorders-live-Dementia', 'Heart Failure-develop-Myocardial Infarction', 'Alzheimer Disease-associated-Brain Diseases, Metabolic', 'Brain Diseases, Metabolic-associated-Alzheimer Disease', 'Diabetes Mellitus-associated-Brain Diseases, Metabolic', 'Brain Diseases, Metabolic-associated-Diabetes Mellitus', 'Dementia-include-Memory Disorders', 'Alzheimer Disease-subjected-Dementia', 'Retinal Diseases-precede-Diabetes Mellitus, Type 2', 'Drug Hypersensitivity-focus-Asthma', 'Drug Hypersensitivity-focus-Dermatitis, Atopic', 'Rhinitis, Allergic-coincide-Asthma', 'Dermatitis, Atopic-associated-Respiratory Insufficiency', 'Respiratory Insufficiency-associated-Dermatitis, Atopic', 'Skin Diseases-associated-Respiratory Insufficiency', 'Respiratory Insufficiency-associated-Skin Diseases', 'Dry Eye Syndromes-include-Vision, Low', 'Vision Disorders-lead-Corneal Dystrophies, Hereditary', 'Blindness-lead-Corneal Dystrophies, Hereditary', 'Corneal Diseases-associated-Retinitis', 'Retinitis-associated-Corneal Diseases', 'Werner Syndrome-exhibit-Atherosclerosis', 'Werner Syndrome-exhibit-Cardiovascular Diseases', 'Alopecia-associated-Coronary Artery Disease', 'Coronary Artery Disease-associated-Alopecia', 'Hearing Disorders-cause-Necrosis', 'Necrosis-cause-Hearing Disorders', 'Diabetes Mellitus-seem-Alzheimer Disease', 'Hearing Disorders-associated-Sensation Disorders', 'Sensation Disorders-associated-Hearing Disorders', 'Diabetes Mellitus-contribute-Dementia', 'Sleep Wake Disorders-experience-Death', 'Olfaction Disorders-accompanied-Parkinson Disease', 'Tremor-associated-Fragile X Syndrome', 'Fragile X Syndrome-associated-Tremor', 'Ataxia-associated-Fragile X Syndrome', 'Fragile X Syndrome-associated-Ataxia', 'Kidney Diseases-remain-Hemorrhage', 'Kidney Diseases-remain-Infections', 'Kidney Diseases-remain-Rupture', 'Constriction, Pathologic-caused-Thrombosis', 'Constriction, Pathologic-caused-Hyperplasia', 'Fractures, Bone-associated-Thrombosis', 'Thrombosis-associated-Fractures, Bone', 'Leg Injuries-associated-Thrombosis', 'Thrombosis-associated-Leg Injuries', 'Nerve Degeneration-observed-Muscular Atrophy', 'Nerve Degeneration-observed-Brain Injuries, Traumatic', 'Neurotoxicity Syndromes-lead-Retinal Degeneration', 'Nerve Degeneration-observed-Stroke', 'Nerve Degeneration-observed-Sclerosis', 'Nerve Degeneration-observed-Amyotrophic Lateral Sclerosis', 'Neurodegenerative Diseases-resolve-Inflammation', 'Nervous System Diseases-evaluate-Pruritus', 'Ischemia-reflect-Seizures', 'Ischemia-related-Seizures', 'Heart Diseases-reflect-Seizures', 'Heart Diseases-related-Seizures', 'Seizures-reflect-Ischemia', 'Seizures-accompany-Ischemia', 'Heart Diseases-related-Ischemia', 'Hematoma-represent-Aneurysm, Ruptured', 'Stroke-reduce-Brain Injuries', 'Fecal Incontinence-associated-Osteoarthritis', 'Osteoarthritis-associated-Fecal Incontinence', 'Fecal Incontinence-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-Fecal Incontinence', 'Fecal Incontinence-associated-Inflammatory Bowel Diseases', 'Inflammatory Bowel Diseases-associated-Fecal Incontinence', 'Diabetes Mellitus-reduce-Hypoglycemia', 'Metabolic Diseases-change-Metabolic Syndrome', 'Metabolic Syndrome-link-Cardiovascular Diseases', 'Anemia-related-HIV Infections', 'Anemia-demonstrated-Death', 'HIV Infections-induce-Anemia', 'Hypotension-provide-Infections', 'Death-confined-Heart Failure', 'Obesity-confined-Chronic Disease', 'Obesity-confined-Heart Failure', 'Mucopolysaccharidosis III-develop-Epilepsy', 'Epilepsy-develop-Death', 'Death-change-Pneumococcal Infections', 'Death-caused-Pneumococcal Infections', 'Pulmonary Disease, Chronic Obstructive-aggravated-Lung Diseases', 'Asthma-reflect-Lung Diseases', 'Kidney Calculi-associated-Atherosclerosis', 'Atherosclerosis-associated-Kidney Calculi', 'Glucose Intolerance-include-Obesity', 'Glucose Intolerance-include-Hyperlipidemias', 'Death-suffer-Diabetes Mellitus', 'Hypothalamic Neoplasms-relate-Metabolic Diseases', 'Hypothalamic Neoplasms-relate-Hyperglycemia', 'Hyperglycemia-include-Metabolic Diseases', 'Heart Failure-screen-Peripheral Nervous System Diseases', 'Neoplasms-dampen-Inflammation', 'Infections-dampen-Inflammation', 'Eye Injuries-include-Wounds and Injuries', 'Peripheral Arterial Disease-target-Cardiovascular Diseases', 'Chromosome Aberrations-used-Multiple Myeloma', 'Hypoalbuminemia-improve-Parkinson Disease', 'Death-determined-Diabetes Mellitus', 'Hypertension-associate-Death', 'Death-associate-Hypertension', 'Obesity-evaluated-Death', 'Death-driven-Heart Failure', 'Chronic Disease-account-Death', 'Obesity-influence-Fractures, Bone', 'Hypercalcemia-corrected-Acute Kidney Injury', 'Hypercalcemia-corrected-Multiple Myeloma', 'Hypercalcemia-corrected-Kidney Diseases', 'Cardiovascular Diseases-become-Renal Insufficiency, Chronic', 'Cardiovascular Diseases-found-Gingivitis', 'Myotonic Dystrophy-undergo-Peripheral Arterial Disease', 'Cleidocranial Dysplasia-comprise-Ventricular Septal Rupture', 'Cleidocranial Dysplasia-comprise-Aortic Valve Stenosis', 'Hyperglycemia-manage-Diabetes Mellitus, Type 2', 'Hyperglycemia-treat-Renal Insufficiency, Chronic', 'Diabetes Mellitus, Type 2-manage-Renal Insufficiency, Chronic', 'Liver Failure-associated-Hepatitis C', 'Hepatitis C-associated-Liver Failure', 'Alzheimer Disease-implement-Dementia', 'Atherosclerosis-owe-Diabetes Mellitus', 'Diabetes Mellitus-undergo-Skin Diseases', 'Diabetes Mellitus-degenerated-Infections', 'Diabetes Mellitus-degenerated-Ulcer', 'Atherosclerosis-undergo-Skin Diseases', 'Atherosclerosis-degenerated-Infections', 'Atherosclerosis-degenerated-Ulcer', 'Skin Diseases-degenerated-Infections', 'Skin Diseases-degenerated-Ulcer', 'Renal Insufficiency-include-Vascular Calcification', 'Inflammation-include-Vascular Calcification', 'Vitamin K Deficiency-include-Bone Neoplasms', 'Diabetes Mellitus-include-Bone Neoplasms', 'Renal Insufficiency-include-Bone Neoplasms', 'Inflammation-include-Bone Neoplasms', 'Breast Neoplasms-increasing-Mastocytosis, Systemic', 'Anisometropia-assess-Cataract', 'Temporomandibular Joint Disorders-produce-Pain', 'Arthritis-caused-Rupture', 'Olfaction Disorders-defined-Neurodegenerative Diseases', 'Diabetes Mellitus-preexist-Dementia', 'Femoral Neck Fractures-displace-Fractures, Bone', 'Cardiovascular Abnormalities-reported-Non-alcoholic Fatty Liver Disease', 'Constipation-caused-Airway Obstruction', 'Deglutition Disorders-imply-Neoplasms', 'Sepsis-caused-Pneumonia', 'Sepsis-characterize-Multiple Organ Failure', 'Pneumonia-develop-Sepsis', 'Deglutition Disorders-found-Sleep Apnea, Obstructive', 'Deglutition Disorders-found-Neck Pain', 'Sleep Apnea, Obstructive-found-Neck Pain', 'Atrial Fibrillation-treat-Hemorrhage', 'Sarcopenia-contribute-Fractures, Bone', 'Urinary Incontinence-report-Colorectal Neoplasms', 'Urinary Incontinence-include-Accidental Injuries', 'Flatulence-report-Accidental Injuries', 'Death-occur-Dyspnea', 'Pneumonia-associated-Cross Infection', 'Cross Infection-associated-Pneumonia', 'Glioblastoma-reduce-Drug-Related Side Effects and Adverse Reactions', 'Turner Syndrome-show-Hearing Loss', 'Hearing Loss, Central-found-Turner Syndrome', 'Otitis-produce-Hearing Loss', 'Hypertension-complicated-Hypotension, Orthostatic', 'Osteoarthritis-consider-Pain', 'Inflammation-triggered-Brain Injuries', 'Neurodegenerative Diseases-triggered-Brain Injuries', 'Aneurysm-affect-Alzheimer Disease', 'Aneurysm-cause-Cerebrovascular Disorders', 'Alzheimer Disease-cause-Cerebrovascular Disorders', 'Pneumonia-complicate-Pulmonary Disease, Chronic Obstructive', 'Endocarditis-trigger-Shock, Septic', 'Shock, Septic-trigger-Death', 'Osteoarthritis-differ-Pain', 'Death-attributed-Wounds and Injuries', 'Pain-suffer-Arthritis, Rheumatoid', 'Pain-suffer-Gout', 'Hypertension-develop-Kidney Diseases', 'Diabetes Mellitus-monitored-Brain Diseases', 'Deglutition Disorders-reveal-Dementia', 'Deglutition Disorders-reveal-Nervous System Diseases', 'Deglutition Disorders-reveal-Cardiovascular Diseases', 'Deglutition Disorders-reveal-Cerebrovascular Disorders', 'Deglutition Disorders-reveal-Paresis', 'Nervous System Diseases-associated-Deglutition Disorders', 'Deglutition Disorders-associated-Nervous System Diseases', 'Cerebrovascular Disorders-associated-Deglutition Disorders', 'Deglutition Disorders-associated-Cerebrovascular Disorders', 'Paresis-associated-Deglutition Disorders', 'Deglutition Disorders-associated-Paresis', 'Ulcer-constitute-Death', 'Cellulitis-constitute-Death', 'Genetic Diseases, Inborn-associated-Atherosclerosis', 'Atherosclerosis-associated-Genetic Diseases, Inborn', 'Death-include-Cellulitis', 'Cough-decreased-Muscular Atrophy', 'Death-observed-Obesity', 'Stroke-play-Parkinson Disease', 'Sarcoma, Kaposi-relapse-Hemorrhage', 'Dermatitis-inhibit-Cardiac Output, Low', 'Dermatitis-prevent-Skin Ulcer', 'Cardiac Output, Low-prevent-Skin Ulcer', 'Neoplasms-exacerbate-Inflammation', 'Cell Transformation, Neoplastic-exacerbate-Inflammation', 'Aneurysm-represent-Alzheimer Disease', 'Heredodegenerative Disorders, Nervous System-include-Brain Injuries', 'Heredodegenerative Disorders, Nervous System-include-Alzheimer Disease', 'Heredodegenerative Disorders, Nervous System-include-Parkinson Disease', 'Heredodegenerative Disorders, Nervous System-include-Spinal Cord Injuries', 'HIV Infections-include-Acquired Immunodeficiency Syndrome', 'Respiratory Tract Infections-cause-Wounds and Injuries', 'Chronic Disease-include-Sarcopenia', 'Chronic Disease-related-Sarcopenia', 'Dysphonia-reveal-Laryngitis', 'Hypotension, Orthostatic-compare-Hypertension', 'Neoplasms-differ-Thyroid Cancer, Papillary', 'Vestibular Diseases-caused-Brain Diseases', 'Thyroid Cancer, Papillary-affect-Death', 'Vascular Calcification-become-Cardiovascular Diseases', 'Endometriosis-decrease-Breast Neoplasms', 'Postoperative Complications-follow-Infections', 'Hemorrhage-occur-Vascular Neoplasms', 'Leukoencephalopathies-include-Gait Ataxia', 'Heredodegenerative Disorders, Nervous System-linked-Alzheimer Disease', 'Atrophy-related-Neurologic Manifestations', 'Obesity-associated-Eclampsia', 'Eclampsia-associated-Obesity', 'Neurologic Manifestations-result-Leukoencephalopathies', 'Neurologic Manifestations-pay-Neurodegenerative Diseases', 'Cartilage Diseases-experience-Osteoarthritis', 'Sarcoidosis-characterized-Granuloma', 'Infections-discriminate-Inflammation', 'Osteoarthritis-influence-Osteoporosis', 'Osteoarthritis-influence-Osteoporotic Fractures', 'Osteoporotic Fractures-decrease-Osteoarthritis', 'Osteoarthritis-influence-Bone Neoplasms', 'Dementia-promote-Neurodegenerative Diseases', 'Disease Progression-characterised-Tremor', 'Disease Progression-characterised-Muscle Rigidity', 'Hypothalamic Neoplasms-show-Hyperkinesis', 'Stroke-suffer-Intracranial Hemorrhages', 'Parkinson Disease-affect-Alzheimer Disease', 'Anemia-associated-Malaria', 'Malaria-associated-Anemia', 'Anemia-associated-HIV Infections', 'HIV Infections-associated-Anemia', 'Malaria-include-Infections', 'HIV Infections-include-Infections', 'Pain-attributed-Joint Diseases', 'Epilepsy, Absence-associated-Stroke', 'Stroke-associated-Epilepsy, Absence', 'Pneumothorax-occur-Lung Diseases', 'Pneumothorax-occur-Pulmonary Disease, Chronic Obstructive', 'Candidiasis, Vulvovaginal-include-Invasive Fungal Infections', 'Pneumothorax-occur-Lung Diseases, Interstitial', 'Pneumothorax-occur-Lung Neoplasms', 'Birt-Hogg-Dube Syndrome-considered-Pneumothorax', 'Birt-Hogg-Dube Syndrome-develop-Pneumothorax', 'Neurodegenerative Diseases-give-Alzheimer Disease', 'Alzheimer Disease-confirm-Neurodegenerative Diseases', 'Pulmonary Disease, Chronic Obstructive-complicated-Respiratory Insufficiency', 'Delirium-manifest-Hyperkinesis', 'Cardiovascular Diseases-estimate-Sleepiness', 'Sleep Wake Disorders-increase-Cardiovascular Diseases', 'Thyroid Diseases-affect-Hypothyroidism', 'Osteoporosis-reduce-Cardiovascular Diseases', 'Osteoporosis-reduce-Alzheimer Disease', 'Lupus Nephritis-show-Infections', 'Heart Failure-control-Death', 'Coronary Artery Disease-become-Aortic Valve Stenosis', 'Ovarian Diseases-observed-Polycystic Ovary Syndrome', 'Cardiac Output, Low-fall-Upper Extremity Deformities, Congenital', 'Wounds and Injuries-follow-Brain Injuries, Traumatic', 'Wounds and Injuries-follow-Fractures, Bone', 'Learning Disabilities-correspond-Alzheimer Disease', 'Tuberculosis, Pulmonary-mitigate-Bone Neoplasms', 'Tuberculosis, Pulmonary-reduce-Osteoporotic Fractures', 'Prediabetic State-indicated-Diabetes Mellitus', 'Neurodegenerative Diseases-quantify-Leukoencephalopathies', 'Neurodegenerative Diseases-quantify-Cerebrovascular Disorders', 'Neurodegenerative Diseases-derived-Alzheimer Disease', 'Neurodegenerative Diseases-affected-Alzheimer Disease', 'Alzheimer Disease-adjusted-Neurodegenerative Diseases', 'Death-remain-Diabetes Mellitus', 'Infections-cause-Fibrosis', 'Infections-lead-Kidney Diseases', 'Diabetes Mellitus, Type 2-cause-Fibrosis', 'Diabetes Mellitus, Type 2-lead-Kidney Diseases', 'Fibrosis-lead-Kidney Diseases', 'Chronic Disease-decrease-Death', 'Coronary Artery Disease-potentiate-Death', 'Pulmonary Disease, Chronic Obstructive-potentiate-Death', 'Gastrointestinal Hemorrhage-done-Stroke', 'Coronary Artery Disease-compare-Cardiovascular Diseases', 'Retinitis-associated-Retinal Diseases', 'Retinal Diseases-associated-Retinitis', 'Stomach Neoplasms-dealt-Lymphoma', 'Urologic Diseases-observed-Immunologic Deficiency Syndromes', 'Immunologic Deficiency Syndromes-observed-Kidney Diseases', 'Immunologic Deficiency Syndromes-observed-Urolithiasis', 'Immunologic Deficiency Syndromes-observed-Infections', 'Immunologic Deficiency Syndromes-observed-Tuberculosis', 'Immunologic Deficiency Syndromes-observed-Aneurysm', 'Immunologic Deficiency Syndromes-observed-Urogenital Neoplasms', 'Immunologic Deficiency Syndromes-observed-Urinary Bladder Diseases', 'Parkinson Disease-characterized-Movement Disorders', 'Tremor-include-Movement Disorders', 'Dyskinesia, Drug-Induced-include-Movement Disorders', 'Death-estimated-Lung Neoplasms', 'Death-estimated-Breast Neoplasms', 'Death-estimated-Melanoma', 'Neoplasms-decline-Melanoma', 'Neoplasms-decline-Lung Neoplasms', 'Colorectal Neoplasms-remain-Neoplasms', 'Neoplasms-rise-Breast Neoplasms', 'Death-predicted-Melanoma', 'Death-predicted-Lung Neoplasms', 'Neoplasms-predicted-Melanoma', 'Neoplasms-predicted-Lung Neoplasms', 'Prostatic Neoplasms-range-Melanoma', 'Sleepiness-fall-Cardiac Output, Low', 'Hyperkalemia-result-Arrhythmias, Cardiac', 'Hyperkalemia-result-Renal Insufficiency, Chronic', 'Death-exclude-Stomach Neoplasms', 'Hyperlipidemias-live-Dementia, Vascular', 'Ischemia-live-Dementia, Vascular', 'Death-achieve-Seizures', 'Aneurysm-present-Hemorrhage', 'Aneurysm-present-Subarachnoid Hemorrhage', 'Neoplasms-warranted-Aneurysm', 'Ossification of Posterior Longitudinal Ligament-investigate-Obesity', 'Sleep Wake Disorders-cause-Alzheimer Disease', 'Cataract-followed-Corneal Diseases', 'Cataract-followed-Glaucoma', 'Heredodegenerative Disorders, Nervous System-cause-Fractures, Bone', 'Cerebellar Ataxia-cause-Fractures, Bone', 'Weight Loss-indicated-Malnutrition', 'Stomach Neoplasms-indicated-Malnutrition', 'Weight Loss-shown-Malnutrition', 'Stomach Neoplasms-shown-Malnutrition', 'Weight Loss-remain-Malnutrition', 'Stomach Neoplasms-remain-Malnutrition', 'Headache-codified-Headache Disorders', 'Headache-include-Migraine Disorders', 'Headache-consider-Migraine Disorders', 'Headache-include-Headache Disorders, Primary', 'Headache-consider-Headache Disorders, Primary', 'Headache-include-Neuralgia', 'Headache-consider-Neuralgia', 'Headache-include-Giant Cell Arteritis', 'Headache-consider-Giant Cell Arteritis', 'Neuralgia-include-Headache', 'Giant Cell Arteritis-include-Headache', 'Atrophy-influence-Fractures, Bone', 'Craniofacial Abnormalities-identified-Malocclusion', 'Heart Arrest--be-Neoplasms', 'Dementia-followed-Nerve Degeneration', 'Nerve Degeneration-associated-Dementia', 'Dementia-associated-Nerve Degeneration', 'Parkinson Disease-associate-Ataxia', 'Ataxia-associate-Parkinson Disease', 'Dementia-estimate-Stroke', 'Stroke-associated-Arteriolosclerosis', 'Arteriolosclerosis-associated-Stroke', 'Atrial Fibrillation-include-Cerebral Infarction', 'Hypertension-include-Cerebral Infarction', 'Diabetes Mellitus-include-Cerebral Infarction', 'Carotid Stenosis-include-Cerebral Infarction', 'Stroke-result-Dementia', 'Cerebrovascular Disorders-adjusted-Death', 'Obesity, Abdominal-reported-Atherosclerosis', 'Obesity, Abdominal-reported-Metabolic Syndrome', 'Eye Diseases-involve-Choroidal Neovascularization', 'Eye Diseases-involve-Rupture', 'Myopia-involve-Eye Diseases', 'Inflammation-defined-Heart Failure', 'Anorexia-limit-Weight Loss', 'Death-compare-Nervous System Diseases', 'Seizures-fit-Coronary Artery Disease', 'Seizures-fit-Heart Failure', 'Seizures-fit-Heart Diseases', 'Seizures-fit-Aortic Valve Stenosis', 'Coronary Artery Disease-associated-Cardiomyopathy, Dilated', 'Cardiomyopathy, Dilated-associated-Coronary Artery Disease', 'Diabetes Mellitus-associated-Cardiomyopathy, Dilated', 'Cardiomyopathy, Dilated-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-Heart Failure, Diastolic', 'Heart Failure, Diastolic-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-Cardiomyopathy, Hypertrophic', 'Cardiomyopathy, Hypertrophic-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-Heart Valve Diseases', 'Heart Valve Diseases-associated-Diabetes Mellitus', 'Dyskeratosis Congenita-alleviate-Drug-Related Side Effects and Adverse Reactions', 'Dry Eye Syndromes-defined-Headache Disorders, Secondary', 'Anisometropia-found-Corneal Diseases', 'Beckwith-Wiedemann Syndrome-appear-Carpal Tunnel Syndrome', 'Metabolic Syndrome-associated-Gout', 'Gout-associated-Metabolic Syndrome', 'Hemorrhage-used-Thrombosis', 'Metabolic Syndrome-associated-Hyperuricemia', 'Hyperuricemia-associated-Metabolic Syndrome', 'Porencephaly-manifest-Nervous System Diseases', 'Porencephaly-manifest-Dementia, Vascular', 'Death-experience-Hepatitis C', 'Porencephaly-manifest-Parkinson Disease, Secondary', 'Death-experience-Hemorrhage', 'Hepatitis C-experience-Hemorrhage', 'Leukoencephalopathies-cause-Urinary Incontinence', 'Bacterial Infections-display-Heart Arrest', 'Bacterial Infections-display-Leukemia, Promyelocytic, Acute', 'Death-include-Weight Loss', 'Arthritis-indicated-Pain', 'Osteoarthritis-evaluate-Pain', 'Vision Disorders-include-Perceptual Disorders', 'Osteoarthritis-measure-Pain', 'Hypoglycemia-remain-Diabetes Mellitus', 'Hypoglycemia-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-Hypoglycemia', 'Cold Injury-defined-Fever', 'Cold Injury-defined-Pharyngeal Diseases', 'Neoplasms-expose-Infections', 'Neoplasms-expose-Opportunistic Infections', 'Opportunistic Infections-include-Infections', 'Memory Disorders-produce-Neoplasms', 'Neoplasms-represent-Skin Neoplasms', 'Hematologic Diseases-combine-Neoplasms', 'Neoplasms-experience-Infertility, Female', 'Death-appear-Neoplasms', 'Fibrosis-indicate-Lipoma', 'Neoplasms-develop-Thyroid Neoplasms', 'Neurodegenerative Diseases-implicated-Myocardial Infarction', 'Neoplasms-implicated-Myocardial Infarction', 'Heart Failure-represent-Inflammation', 'Heart Failure-portend-Death', 'Death-suffer-Pulmonary Disease, Chronic Obstructive', 'Neoplasms-appear-Eyelid Diseases', 'Psoriasis-associated-Obesity', 'Obesity-associated-Psoriasis', 'Renal Insufficiency, Chronic-entail-Death', 'Hyponatremia-respond-Muscle Hypertonia', 'Hypothyroidism-provoke-Hyponatremia', 'Heart Failure-do-Renal Insufficiency', 'Heart Failure-do-Pulmonary Disease, Chronic Obstructive', 'Heart Failure-overwhelm-Infections', 'Heart Failure-overwhelm-Ischemia', 'Renal Insufficiency-tend-Infections', 'Renal Insufficiency-tend-Ischemia', 'Pulmonary Disease, Chronic Obstructive-tend-Infections', 'Pulmonary Disease, Chronic Obstructive-tend-Ischemia', 'Hemangioma-cause-Hematoma, Epidural, Spinal', 'Hemangioma-reveal-Spinal Stenosis', 'Hemangioma-result-Fractures, Bone', 'Xerostomia-Establish-Alzheimer Disease', 'Acquired Immunodeficiency Syndrome-related-Diabetes Mellitus', 'Acquired Immunodeficiency Syndrome-related-Cardiovascular Diseases', 'Acquired Immunodeficiency Syndrome-related-Osteoporosis', 'Acquired Immunodeficiency Syndrome-related-Bone Diseases, Metabolic', 'Acquired Immunodeficiency Syndrome-related-Fractures, Bone', 'Kidney Diseases-caused-Arbovirus Infections', 'Kidney Diseases-remain-Renal Insufficiency, Chronic', 'Sclerosis-associated-Memory Disorders', 'Memory Disorders-associated-Sclerosis', 'Hyperkinesis-lead-Cryopyrin-Associated Periodic Syndromes', 'Osteoarthritis-reduce-Pain', 'Brain Diseases-supported-Cerebral Infarction', 'Brain Diseases-provide-Heart Arrest', 'Brain Diseases-provide-Delirium', 'Neoplasms-given-Drug-Related Side Effects and Adverse Reactions', 'Neoplasms-result-Drug-Related Side Effects and Adverse Reactions', 'Neoplasms-assess-Drug-Related Side Effects and Adverse Reactions', 'Leukoencephalopathies-determine-Cardiovascular Abnormalities', 'Primary Ovarian Insufficiency-cause-Infertility, Female', 'Ovarian Diseases-include-Polycystic Ovary Syndrome', 'Polycystic Ovary Syndrome-cause-Infertility, Female', 'Ovarian Neoplasms-disrupt-Ovarian Diseases', 'Sleep Deprivation-treat-Infertility, Female', 'Liver Failure-involve-Mitochondrial Diseases', 'Metabolic Diseases-include-Neurodegenerative Diseases', 'Atrial Fibrillation-contribute-Alzheimer Disease', 'Inflammation-lead-Neuralgia', 'Inflammation-implicated-Diabetes Mellitus, Type 2', 'Inflammation-apprais-Diabetes Mellitus, Type 2', 'Inflammation-apprais-Alzheimer Disease', 'Neuralgia-include-Malnutrition', 'Peptic Ulcer-include-Infections', 'Peptic Ulcer-determine-Neuralgia', 'Ureteral Obstruction-cause-Kidney Diseases', 'Ureteral Obstruction-cause-Adenocarcinoma', 'Ureteral Obstruction-cause-Inflammation', 'Ureteral Obstruction-cause-Fibrosis', 'Kidney Diseases-characterized-Adenocarcinoma', 'Ureteral Obstruction-illustrate-Inflammation', 'Ureteral Obstruction-illustrate-Fibrosis', 'Ureteral Obstruction-illustrate-Acute Kidney Injury', 'Airway Obstruction-illustrate-Inflammation', 'Airway Obstruction-illustrate-Fibrosis', 'Airway Obstruction-illustrate-Acute Kidney Injury', 'Alzheimer Disease-characterize-Neurodegenerative Diseases', 'Hypertension-combined-Obesity', 'Obesity-combined-Hypertension', 'Dyslipidemias-combined-Hypertension', 'Delirium-predict-Dementia', 'Delirium-associated-Dehydration', 'Dehydration-associated-Delirium', 'Arbovirus Infections-cause-Infections', 'Chemical and Drug Induced Liver Injury-indicate-Blood Coagulation Disorders', 'Peroxisomal Disorders-identified-Demyelinating Diseases', 'Brain Diseases-encountered-Demyelinating Diseases', 'Brain Diseases-encountered-Inflammation', 'Vertigo-suffer-Neck Pain', 'Klebsiella Infections-bite-Mitral Valve Stenosis', 'Epilepsy-follow-Seizures', 'Retinal Degeneration-predispose-Fractures, Bone', 'Nervous System Diseases-caused-Mitochondrial Diseases', 'Vitreous Detachment-include-Macular Edema', 'Heart Diseases-predict-Cerebral Infarction', 'Heart Diseases-predict-Ischemia', 'Death-predict-Ischemia', 'Albuminuria-reported-Cardiovascular Diseases', 'Alzheimer Disease-target-Communicable Diseases', 'Gait Disorders, Neurologic-comprise-Dyspepsia', 'Gait Disorders, Neurologic-include-Dyspepsia', 'Hyponatremia-occur-Polydipsia', 'Neurotoxicity Syndromes-produce-Memory Disorders', 'Periodontal Diseases-associated-Obesity', 'Obesity-associated-Periodontal Diseases', 'Hypertension-recruit-Renal Insufficiency, Chronic', 'Proteinuria-associate-Hypertension', 'Hypertension-associate-Proteinuria', 'Ischemia-abrogate-Neurologic Manifestations', 'Heart Failure-underlie-Hypertension', 'Arteritis-characterized-Inflammation', 'Diabetes Mellitus-considered-Erectile Dysfunction', 'Diabetes Mellitus-considered-Coronary Artery Disease', 'Erectile Dysfunction-considered-Coronary Artery Disease', 'Hypogonadism-observed-Diabetes Mellitus', 'Hypogonadism-observed-Erectile Dysfunction', 'Cardiovascular Diseases-present-Aortic Aneurysm, Abdominal', 'Osteoporotic Fractures-recognized-Death', 'Fractures, Bone-affect-Bone Diseases', 'Fractures, Bone-affect-Osteoporosis', 'Atrophy-support-Fractures, Stress', 'Ankle Fractures-considered-Osteoporotic Fractures', 'Osteoarthritis-regarded-Joint Diseases', 'Joint Diseases-observed-Inflammation', 'Joint Diseases-observed-Synovitis', 'Hemorrhage-include-Death', 'Renal Insufficiency-include-Death', 'Arthritis-funded-Adrenal Insufficiency', 'Arthritis-funded-Hyperparathyroidism', 'Arthritis-funded-Bone Neoplasms', 'Arthritis-funded-Muscular Diseases', 'Adrenal Insufficiency-lead-Hyperparathyroidism', 'Stroke-reduce-Heart Failure', 'Adrenal Insufficiency-lead-Muscular Diseases', 'Hyperparathyroidism-lead-Fractures, Bone', 'Pulmonary Arterial Hypertension-distinguish-Hypertension, Pulmonary', 'Atrial Fibrillation-exhibit-Syncope', 'Kidney Diseases-exhibit-Syncope', 'Stroke-correlated-Leukoaraiosis', 'Hypertension-correlated-Leukoaraiosis', 'Pain Insensitivity, Congenital-considered-Pain', 'Nervous System Diseases-increase-Death', 'Hip Fractures-receive-Pain', 'Obesity-contribute-Metabolic Syndrome', 'Drug-Related Side Effects and Adverse Reactions-result-Heart Failure', 'Death-predict-Airway Obstruction', 'Infections-caused-Respiratory Tract Infections', 'Acatalasia-suffer-Methemoglobinemia', 'Acatalasia-suffer-Hemolysis', 'Methemoglobinemia-cause-Acatalasia', 'Muscle Weakness-screen-Sarcopenia', 'Myocardial Infarction-lead-Arrhythmias, Cardiac', 'Neurodegenerative Diseases-associated-Encephalomyelitis, Autoimmune, Experimental', 'Encephalomyelitis, Autoimmune, Experimental-associated-Neurodegenerative Diseases', 'Myocardial Infarction-lead-Heart Failure', 'Neurodegenerative Diseases-increase-Inflammation', 'Neurodegenerative Diseases-increase-Demyelinating Diseases', 'Encephalomyelitis, Autoimmune, Experimental-increase-Inflammation', 'Encephalomyelitis, Autoimmune, Experimental-increase-Demyelinating Diseases', 'Diabetes Mellitus-experience-Dementia', 'Diabetes Mellitus-experience-Urinary Incontinence', 'Infections-present-Meningitis, Bacterial', 'Infections-present-Meningoencephalitis', 'Infections-present-Acute Febrile Encephalopathy', 'Renal Insufficiency, Chronic-exhibit-Death', 'Vascular Calcification-associate-Death', 'Death-associate-Vascular Calcification', 'Vascular Calcification-exhibit-Renal Insufficiency, Chronic', 'Alzheimer Disease-diagnose-Memory Disorders', 'Parkinson Disease-experience-Ossification of Posterior Longitudinal Ligament', 'Pain-predict-Sarcopenia', 'Diabetes Mellitus-target-Dementia', 'Diabetes Mellitus-include-Osteoporosis', 'Aneurysm-precede-Rupture', 'Pulmonary Disease, Chronic Obstructive-increase-Respiratory Tract Infections', 'Pulmonary Disease, Chronic Obstructive-colonized-Arbovirus Infections', 'Osteoarthritis-defined-Arthralgia', 'Osteoarthritis-defined-Neurologic Manifestations', 'Arbovirus Infections-cause-Inflammation', 'Osteoarthritis-defined-Joint Diseases', 'Neurologic Manifestations-caused-Joint Diseases', 'Carcinoma, Squamous Cell-associated-Urinary Bladder Calculi', 'Urinary Bladder Calculi-associated-Carcinoma, Squamous Cell', 'Carcinoma, Squamous Cell-make-Urinary Bladder Neoplasms', 'Neuroblastoma-exposed-Astrocytoma', 'Supranuclear Palsy, Progressive-suggest-Neurodegenerative Diseases', 'Hypertension-increase-Heart Valve Diseases', 'Hypertension-increase-Arrhythmias, Cardiac', 'Dementia-suffer-Myocardial Infarction', 'Neoplasms-confront-Flank Pain', 'Atrial Fibrillation-affect-Cerebral Infarction', 'Cerebral Infarction-diagnosed-Atrial Fibrillation', 'Atrial Fibrillation-show-Cerebral Infarction', 'Death-use-Diabetes Mellitus', 'Urinary Incontinence-increase-Fecal Incontinence', 'Diabetes Mellitus-increase-Fecal Incontinence', 'Dementia-increase-Fecal Incontinence', 'Asthma-increase-Fecal Incontinence', 'Urinary Incontinence-predict-Fecal Incontinence', 'Metabolic Syndrome-associated-Renal Insufficiency, Chronic', 'Renal Insufficiency, Chronic-associated-Metabolic Syndrome', 'Chronic Disease-suffer-Meningitis, Pneumococcal', 'Coronary Artery Disease-aggravated-Hyperthyroidism', 'Coronary Artery Disease-aggravated-Hypothyroidism', 'Obesity-investigate-Brain Infarction', 'Venous Thromboembolism-cause-Death', 'Headache Disorders, Secondary-experience-Cholecystitis', 'Intermittent Claudication-include-Low Back Pain', 'Spondylitis-clarify-Infections', 'Leukemoid Reaction-contribute-Death', 'Death-found-Sepsis', 'Gray Platelet Syndrome-progress-Diabetes Mellitus, Type 1', 'Dementia-progress-Diabetes Mellitus, Type 1', 'Diabetes Mellitus-associated-Ventricular Fibrillation', 'Ventricular Fibrillation-associated-Diabetes Mellitus', 'Hyperlipidemias-associated-Heart Failure', 'Heart Failure-associated-Hyperlipidemias', 'Hyperlipidemias-associated-Infarction', 'Infarction-associated-Hyperlipidemias', 'Hyperlipidemias-associated-Ventricular Fibrillation', 'Ventricular Fibrillation-associated-Hyperlipidemias', 'Coronary Artery Disease-associated-Infarction', 'Infarction-associated-Coronary Artery Disease', 'Coronary Artery Disease-associated-Ventricular Fibrillation', 'Ventricular Fibrillation-associated-Coronary Artery Disease', 'Fractures, Bone-develop-Pseudarthrosis', 'Death-persist-Kidney Failure, Chronic', 'Epilepsy-diagnosed-Status Epilepticus', 'Diabetes Mellitus-follow-Arthritis', 'Infections-follow-Diabetes Mellitus', 'Pneumonia-follow-Diabetes Mellitus', 'Joint Diseases-follow-Diabetes Mellitus', 'Osteoarthritis-follow-Diabetes Mellitus', 'Diabetes Mellitus-noted-End Stage Liver Disease', 'Diabetes Mellitus-exist-Infections', 'End Stage Liver Disease-exist-Infections', 'Diabetes Mellitus-ascertained-Hypotension', 'Cataract-associate-Endophthalmitis', 'Endophthalmitis-associate-Cataract', 'Corneal Diseases-associate-Endophthalmitis', 'Endophthalmitis-associate-Corneal Diseases', 'Rupture-associate-Endophthalmitis', 'Endophthalmitis-associate-Rupture', 'Ocular Hypertension-associate-Endophthalmitis', 'Endophthalmitis-associate-Ocular Hypertension', 'Stroke-test-Syncope, Vasovagal', 'Death-follow-Fractures, Bone', 'Orbital Neoplasms-comprise-Neoplasms', 'Orbital Neoplasms-comprise-Orbital Diseases', 'Neoplasms-comprise-Orbital Diseases', 'Parkinson Disease-screen-Nervous System Diseases', 'Nervous System Diseases-described-Parkinson Disease', 'Parkinson Disease-diagnosed-Nervous System Diseases', 'Parkinson Disease-correlate-Nervous System Diseases', 'Memory Disorders-distinguish-Alzheimer Disease', 'Shock-mitigate-Ventricular Fibrillation', 'Heart Arrest-enter-Kidney Diseases', 'Heart Arrest-enter-Renal Insufficiency, Chronic', 'Diffuse Axonal Injury-present-Brain Injuries', 'Alzheimer Disease-suffer-Death', 'Central Nervous System Diseases-classified-Stroke', 'Central Nervous System Diseases-classified-Brain Diseases', 'Central Nervous System Diseases-classified-Delirium', 'Central Nervous System Diseases-classified-Postoperative Cognitive Complications', 'Cerebrovascular Disorders-associated-Postoperative Cognitive Complications', 'Postoperative Cognitive Complications-associated-Cerebrovascular Disorders', 'Delirium-include-Brain Diseases', 'Postoperative Cognitive Complications-include-Brain Diseases', 'Carotid Artery Diseases-cause-Constriction, Pathologic', 'Drug Hypersensitivity-cause-Hypotension', 'Drug Hypersensitivity-lead-Syncope', 'Drug Hypersensitivity-associated-Hypotension', 'Hypotension-associated-Drug Hypersensitivity', 'Death-account-Neoplasms', 'Dementia-put-Delirium', 'Fatigue-decrease-Death', 'Bone Marrow Diseases-monitor-Pain', 'Bone Marrow Diseases-monitor-Osteoarthritis', 'Bone Marrow Diseases-linked-Pain', 'Osteoporotic Fractures-associated-Heart Failure', 'Heart Failure-associated-Osteoporotic Fractures', 'Shock, Septic-develop-Fasciitis, Necrotizing', 'Infections-associated-Osteoporosis', 'Osteoporosis-associated-Infections', 'Bone Diseases, Metabolic-found-Osteoporosis', 'Fractures, Bone-increased-Osteoporosis', 'Renal Insufficiency, Chronic-associated-Stroke', 'Stroke-associated-Renal Insufficiency, Chronic', 'Renal Insufficiency, Chronic-associated-Erectile Dysfunction', 'Erectile Dysfunction-associated-Renal Insufficiency, Chronic', 'Hypertension-appear-Obesity', 'West Nile Fever-result-Encephalitis', 'West Nile Fever-result-Paralysis', 'Infections-result-Fever', 'Infections-result-West Nile Fever', 'Infections-result-Encephalitis', 'Infections-result-Paralysis', 'Fever-cause-Encephalitis', 'Fever-cause-Paralysis', 'West Nile Fever-cause-Encephalitis', 'West Nile Fever-cause-Paralysis', 'Ulcer-observed-Mandibular Nerve Injuries', 'Ischemia-play-Ulcer', 'Lymphatic Diseases-found-Lymphoma', 'Lymphatic Diseases-found-Neoplasm Metastasis', 'Lymphatic Diseases-found-Urinary Bladder Neoplasms', 'Parkinson Disease-compare-Sleep Wake Disorders', 'Parkinson Disease-characterized-Sleep Wake Disorders', 'Parkinson Disease-compare-Dementia', 'Parkinson Disease-compare-Psychoses, Substance-Induced', 'Parkinson Disease-characterized-Psychoses, Substance-Induced', 'Wounds and Injuries-undergo-Stroke', 'CHARGE Syndrome-characterized-Bone Marrow Failure Disorders', 'CHARGE Syndrome-characterized-Immunologic Deficiency Syndromes', 'CHARGE Syndrome-characterized-Abnormalities, Drug-Induced', 'Coronary Artery Disease-limit-Necrosis', 'Coronary Artery Disease-attenuate-Reperfusion Injury', 'Death-limit-Necrosis', 'Death-cause-Ischemia', 'Death-attenuate-Reperfusion Injury', 'Ischemia-cause-Death', 'Necrosis-caused-Ischemia', 'Necrosis-attenuate-Reperfusion Injury', 'Ischemia-limit-Necrosis', 'Intervertebral Disc Degeneration-result-Spinal Stenosis', 'Heredodegenerative Disorders, Nervous System-diagnose-Movement Disorders', 'Femoral Fractures-associated-Delirium', 'Delirium-associated-Femoral Fractures', 'Femoral Fractures-performed-Delirium', 'Asthma-counter-Airway Obstruction', 'Status Epilepticus-report-Chronic Disease', 'Chronic Disease-suggest-Infections', 'Chronic Disease-investigate-HIV Infections', 'Hip Fractures-complicated-Infections', 'Hip Fractures-complicated-Delirium', 'Ischemia-improve-Ventricular Remodeling', 'Hypertension-document-Cardiovascular Diseases', 'Pain-reduce-Hip Fractures', 'Death-lead-Neurodegenerative Diseases', 'Dementia-based-Alzheimer Disease', 'Muscular Diseases-prevent-Sarcopenia', 'Melanoma-occur-Skin Neoplasms', 'Urinary Bladder Neoplasms-recognized-Neoplasms', 'Cardiovascular Diseases-determine-Stroke, Lacunar', 'Periodontal Diseases-tend-Infarction', 'Periodontal Diseases-increase-Infarction', 'Inflammation-reduce-Wounds and Injuries', 'Respiratory Insufficiency-associated-Signs and Symptoms, Respiratory', 'Signs and Symptoms, Respiratory-associated-Respiratory Insufficiency', 'Ischemia-lead-Cerebrovascular Trauma', 'Ischemia-lead-Alzheimer Disease', 'Heart Arrest-promote-Neoplasms', 'Peroxisomal Disorders-associated-Metabolism, Inborn Errors', 'Metabolism, Inborn Errors-associated-Peroxisomal Disorders', 'Peroxisomal Disorders-associated-Neurodegenerative Diseases', 'Neurodegenerative Diseases-associated-Peroxisomal Disorders', 'Peroxisomal Disorders-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-Peroxisomal Disorders', 'Peroxisomal Disorders-associated-Neoplasms', 'Neoplasms-associated-Peroxisomal Disorders', 'Mastocytosis, Systemic-include-Nervous System Diseases', 'Nervous System Diseases-associated-Neoplasms', 'Neoplasms-associated-Nervous System Diseases', 'Alzheimer Disease-characterized-Encephalitis', 'Vestibular Neuronitis-pass-Vertigo', 'Metabolic Syndrome-support-Nervous System Diseases', 'Hyperglycemia-reduce-Nervous System Diseases', 'Hearing Loss, Central-include-Nervous System Diseases', 'Atrophy-lead-Hearing Loss, Central', 'Diabetes Mellitus-include-Fecal Incontinence', 'Osteoarthritis-include-Fecal Incontinence', 'Urinary Incontinence-include-Fecal Incontinence', 'Pulmonary Disease, Chronic Obstructive-associated-Gastroesophageal Reflux', 'Gastroesophageal Reflux-associated-Pulmonary Disease, Chronic Obstructive', 'Diabetes Mellitus-protect-Sarcopenia', 'Cardiovascular Diseases-protect-Sarcopenia', 'Neoplasms-protect-Sarcopenia', 'Thoracic Outlet Syndrome-associated-Leukoencephalopathies', 'Leukoencephalopathies-associated-Thoracic Outlet Syndrome', 'Osteolysis-reported-Infections', 'Osteolysis-reported-Neoplasms', 'Osteolysis-reported-Hematologic Diseases', 'Rhinitis, Allergic-diagnose-Asthma', 'Rhinitis-defined-Cold Injury', 'Heart Failure-challenge-Pulmonary Arterial Hypertension', 'Heart Diseases-cause-Hypertension, Pulmonary', 'Neoplasms-predominate-Death', 'Neoplasms-decrease-Mouth Neoplasms', 'Atrophy-relate-Hereditary Breast and Ovarian Cancer Syndrome', 'Hip Dislocation-compare-Femoral Neck Fractures', 'HIV Infections-checked-Muscle Weakness', 'Fractures, Bone-keep-Hypothermia', 'Pancreatitis, Acute Necrotizing-keep-Hypothermia', 'Death-complicate-Fractures, Bone', 'Hypothermia-complicate-Fractures, Bone', 'Hypothermia-occur-Chronic Disease', 'Coronary Artery Disease-underlie-Diabetes Mellitus', 'Coronary Artery Disease-underlie-Kidney Failure, Chronic', 'Penile Induration-define-Fibrosis', 'Penile Induration-linked-Fibrosis', 'Lymphoma-represent-Neoplasms', 'Leukemia, B-Cell-represent-Neoplasms', 'Tremor-frame-Death', 'Tremor-bind-Death', 'Vision Disorders-frame-Death', 'Vision Disorders-bind-Death', 'Sleep Wake Disorders-observed-Memory Disorders', 'REM Sleep Behavior Disorder-show-Sleep Wake Disorders', 'Sleep Wake Disorders-show-REM Sleep Behavior Disorder', 'Sleep Wake Disorders-diagnosed-REM Sleep Behavior Disorder', 'Deglutition Disorders-give-Pneumonia, Aspiration', 'Sleepiness-diagnosed-Sleep Wake Disorders', 'Neoplasms-include-Invasive Fungal Infections', 'Neoplasms-render-Invasive Fungal Infections', 'Dementia-show-Diffuse Neurofibrillary Tangles with Calcification', 'TDP-43 Proteinopathies-correlate-Sclerosis', 'Diabetes Mellitus-conduct-Heart Diseases', 'Diabetes Mellitus-conduct-Renal Insufficiency, Chronic', 'Death-include-Heart Diseases', 'Genetic Diseases, Inborn-cause-Hypertension', 'Hemorrhage-change-Retinitis', 'Diabetes Mellitus-mediated-Alzheimer Disease', 'Diabetes Mellitus-seen-Aneurysm', 'Multiple Organ Failure-contribute-Metabolic Diseases', 'Takotsubo Cardiomyopathy-lead-Heart Diseases', 'Metabolic Diseases-associated-Neurodegenerative Diseases', 'Neurodegenerative Diseases-associated-Metabolic Diseases', 'Liver Cirrhosis-include-Chronic Disease', 'Neoplasms-lead-Osteoporosis', 'Multiple Organ Failure-lead-Osteoporosis', 'Lung Diseases-associated-Hypoxia', 'Hypoxia-associated-Lung Diseases', 'Cystic Fibrosis-occur-Hypoxia', 'Myalgia-affect-Sarcopenia', 'Wounds and Injuries-affect-Sarcopenia', 'Neuromuscular Diseases-remain-Pain', 'Sclerosis-remain-Pain', 'Skin Neoplasms-reported-Death', 'Pulmonary Disease, Chronic Obstructive-increase-Aneurysm', 'End Stage Liver Disease-diagnosed-Death', 'Death-compare-Stroke', 'Diabetes Mellitus-lead-Neoplasms', 'Diabetes Mellitus, Type 2-include-Obesity', 'Renal Insufficiency, Chronic-coupled-Death', 'Airway Obstruction-occur-Asthma', 'Airway Obstruction-occur-Pulmonary Disease, Chronic Obstructive', 'Asthma-exist-Pulmonary Disease, Chronic Obstructive', 'Airway Obstruction-exist-Pulmonary Disease, Chronic Obstructive', 'Pulmonary Disease, Chronic Obstructive-predicted-Airway Obstruction', 'Asthma-predicted-Airway Obstruction', 'Cardiac Output, Low-remain-Dementia', 'Gastrointestinal Diseases-increase-Colonic Neoplasms', 'Musculoskeletal Diseases-seek-Pain', 'Proteinuria-involved-Nephritis, Interstitial', 'Neoplasms-improve-Urinary Bladder Neoplasms', 'Genetic Diseases, Inborn-characterized-Hematologic Diseases', 'Genetic Diseases, Inborn-characterized-Aneurysm', 'Hypertrophy, Left Ventricular-compare-Osteoarthropathy, Primary Hypertrophic', 'Hypertension-compare-Osteoarthropathy, Primary Hypertrophic', 'Frontotemporal Lobar Degeneration-hippocampal-Atrophy', 'Frontotemporal Lobar Degeneration-include-Atrophy', 'Corneal Injuries-cause-Blindness', 'Corneal Ulcer-cause-Blindness', 'Corneal Ulcer-associated-Corneal Injuries', 'Corneal Injuries-associated-Corneal Ulcer', 'Neoplasms-associated-Respiratory Tract Diseases', 'Respiratory Tract Diseases-associated-Neoplasms', 'Stroke-associated-Wounds and Injuries', 'Wounds and Injuries-associated-Stroke', 'Obesity-develop-Fatty Liver', 'Dysbiosis-display-Colitis', 'Inflammation-evaluate-Respiratory Tract Diseases', 'Inflammation-result-Infections', 'Inflammation-result-Diabetes Mellitus, Type 2', 'Inflammation-associated-Fibrosis', 'Fibrosis-associated-Inflammation', 'Sleep Wake Disorders-cope-Cardiac Output, Low', 'Lipoma-associated-Metabolic Diseases', 'Metabolic Diseases-associated-Lipoma', 'Lipoma-associated-Neurodegenerative Diseases', 'Neurodegenerative Diseases-associated-Lipoma', 'Lipoma-associated-Inflammation', 'Inflammation-associated-Lipoma', 'Mitral Valve Insufficiency-incur-Death', 'Fatigue-experienced-Neoplasms', 'Skin Neoplasms-occur-Ulcer', 'Skin Neoplasms-lead-Facial Injuries', 'Ulcer-lead-Facial Injuries', 'Seizures-improve-Pain', 'Dyspnea-encompass-Respiratory Insufficiency', 'Dyspnea-experienced-Neuromuscular Diseases', 'Dyspnea-experienced-Neoplasms', 'Hypertension-treat-Diabetes Mellitus', 'Hypertension-treat-Renal Insufficiency, Chronic', 'Diabetes Mellitus-treat-Death', 'Renal Insufficiency, Chronic-treat-Death', 'Nephrotic Syndrome-remembered-Edema', 'Nephrotic Syndrome-remembered-Proteinuria', 'Death-survive-Acute Kidney Injury', 'Drug-Related Side Effects and Adverse Reactions-related-Hypertension', 'Cardiovascular Diseases-bring-Death', 'Carcinoma in Situ-increase-Sleep Initiation and Maintenance Disorders', 'Central Nervous System Diseases-cause-Dementia', 'Coinfection-evaluated-HIV Infections', 'Acute Kidney Injury-identify-Death', 'Cerebrovascular Disorders-identify-Death', 'Peripheral Vascular Diseases-identify-Death', 'Gastrointestinal Hemorrhage-identify-Death', 'Heart Failure-identify-Death', 'Multiple Sclerosis-related-Death', 'Multiple Sclerosis-considered-Death', 'Renal Insufficiency-seen-Hypertension', 'Renal Insufficiency-seen-Arteriosclerosis', 'Hematoma, Subdural, Chronic-present-Thromboembolism', 'Neoplasms-comprised-Testicular Neoplasms', 'Neoplasms-comprised-Sarcoma', 'Neoplasms-comprised-Melanoma', 'Neoplasms-comprised-Thyroid Neoplasms', 'Neoplasms-recognize-Drug-Related Side Effects and Adverse Reactions', 'Hypotension, Orthostatic-linked-Nervous System Diseases', 'Hypotension, Orthostatic-accompanied-Syncope', 'Obesity-accelerate-Sarcopenia', 'Obesity-place-Diabetes Mellitus', 'Communicable Diseases-include-Lung Diseases', 'Emphysema-include-Lung Diseases', 'Idiopathic Pulmonary Fibrosis-include-Lung Diseases', 'Sotos Syndrome-provide-Stroke', 'Stroke-enhance-Atherosclerosis', 'Urinary Incontinence-use-Cardiac Output, Low', 'Urinary Incontinence-detect-Cardiac Output, Low', 'Hepatitis B-close-Infections', 'Hepatitis B, Chronic-cause-Fibrosis', 'Hepatitis B-cause-Fibrosis', 'Delirium-include-Postoperative Cognitive Complications', 'Ischemia-cause-Arrhythmias, Cardiac', 'Heart Failure-cause-Arrhythmias, Cardiac', 'Heart Defects, Congenital-cause-Arrhythmias, Cardiac', 'Hip Fractures-result-Osteoporosis', 'Renal Artery Obstruction-remain-Renal Insufficiency', 'Renal Artery Obstruction-remain-Kidney Diseases', 'Hypertension-occur-Pheochromocytoma', 'Hypertension-occur-Paraganglioma', 'Pheochromocytoma-diagnose-Hypertension', 'Paraganglioma-diagnose-Hypertension', 'Hypotension, Orthostatic-diagnose-Hypertension', 'Fatty Liver-evolve-Inflammation', 'Hypertension-randomized-Weight Loss', 'Death-consider-Fistula', 'Inflammation-associated-Hepatitis C', 'Hepatitis C-associated-Inflammation', 'Fistula-associate-Death', 'Death-associate-Fistula', 'Osteoporosis-spent-Osteoporotic Fractures', 'Bone Diseases-associated-Fractures, Bone', 'Fractures, Bone-associated-Bone Diseases', 'Venous Insufficiency-described-Multiple Sclerosis', 'Mitochondrial Diseases-remain-Nerve Degeneration', 'Neurologic Manifestations-remain-Nerve Degeneration', 'Nerve Degeneration-observed-Mitochondrial Diseases', 'Nerve Degeneration-observed-Parkinson Disease', 'Mitochondrial Diseases-lead-Nerve Degeneration', 'Atrophy-come-Spinal Cord Injuries', 'Albuminuria-achieve-Hypertension', 'Delirium-include-Nervous System Diseases', 'Delirium-include-Anemia', 'Delirium-include-Weight Loss', 'Atrophy-associated-Cerebral Infarction', 'Cerebral Infarction-associated-Atrophy', 'Periodontitis-decrease-Tooth Loss', 'Atrial Fibrillation-prevented-Stroke', 'Bruxism-associated-Headache', 'Headache-associated-Bruxism', 'Bruxism-associated-Toothache', 'Toothache-associated-Bruxism', 'Bruxism-associated-Facial Pain', 'Facial Pain-associated-Bruxism', 'Bruxism-associated-Fatigue', 'Fatigue-associated-Bruxism', 'Periodontal Diseases-defined-Periodontal Attachment Loss', 'Mitochondrial Diseases-include-Neoplasms', 'Mitochondrial Diseases-implicated-Neoplasms', 'Death-review-Mitochondrial Diseases', 'Death-determine-Mitochondrial Diseases', 'Mitochondrial Diseases-include-Diabetes Mellitus', 'Inflammation-investigate-Metabolic Diseases', 'Nerve Degeneration-reverse-HIV Infections', 'Esophageal Neoplasms-include-Neoplasms', 'Lymphoma-found-Heart Neoplasms', 'Glucose Metabolism Disorders-affected-Sleep Wake Disorders', 'Infections-result-Heredodegenerative Disorders, Nervous System', 'Hypotension-associated-Renal Insufficiency, Chronic', 'Renal Insufficiency, Chronic-associated-Hypotension', 'Alzheimer Disease-understand-Dementia', 'Tuberculosis-seen-Diabetes Mellitus', 'Death-document-Stroke', 'Death, Sudden-document-Stroke', 'Stroke-document-Heart Failure', 'Atrial Fibrillation-involve-Cardiomyopathies', 'Atrial Fibrillation-underlie-Cardiomyopathies', 'Atrial Fibrillation-assess-Hemorrhage', 'Alzheimer Disease-screened-Dementia', 'Osteoporosis-involve-Fractures, Bone', 'Diabetes Mellitus-suffer-Obesity', 'Glaucoma, Open-Angle-prevent-Blindness', 'Diabetes Mellitus-prevent-Blindness', 'Hypertension-observed-Cardiomyopathy, Hypertrophic', 'Hypertension-observed-Heart Diseases', 'Hypertension-observed-Vascular Calcification', 'Alzheimer Disease-become-Death', 'Alzheimer Disease-treat-Chronic Disease', 'Kearns-Sayre Syndrome-provide-Nerve Degeneration', 'Wounds and Injuries-develop-Seizures', 'Wounds and Injuries-develop-Brain Injuries, Traumatic', 'Seizures-develop-Brain Injuries, Traumatic', 'Inflammation-accelerate-Muscular Diseases', 'Choledocholithiasis-present-Pain', 'Choledocholithiasis-associated-Death', 'Death-associated-Choledocholithiasis', 'Coronary Artery Disease-identify-Renal Insufficiency, Chronic', 'Liver Failure-cause-Hypertension', 'Fat Necrosis-enter-Obesity', 'Diabetes Mellitus, Type 2-associated-Colorectal Neoplasms', 'Colorectal Neoplasms-associated-Diabetes Mellitus, Type 2', 'Myotonic Dystrophy-lead-Hypoglycemia', 'Myotonic Dystrophy-develop-Dementia', 'Stroke-increased-Coronary Restenosis', 'Stroke-increased-Coronary Artery Disease', 'Anemia-known-Dementia', 'Dementia-offer-Anemia', 'Metabolic Syndrome-considered-Cardiovascular Diseases', 'Friedreich Ataxia-treat-Neuronal Ceroid-Lipofuscinoses', 'Cardiomyopathy, Hypertrophic-investigate-Hypertension', 'Diabetes Mellitus-disappear-Metabolic Syndrome', 'Hypertension-disappear-Metabolic Syndrome', 'Hypertension-associate-Hypotension', 'Hypotension-associate-Hypertension', 'Metabolic Syndrome-associate-Hypotension', 'Hypotension-associate-Metabolic Syndrome', 'Ovarian Diseases-fail-Ovarian Neoplasms', 'Sleep Initiation and Maintenance Disorders-characterized-Cardiac Output, Low', 'Sleep Initiation and Maintenance Disorders-characterized-Diurnal Enuresis', 'Diabetes Mellitus-take-Proteinuria', 'Obesity-take-Proteinuria', 'Osteoarthritis-identified-Malocclusion', 'Pain-longstand-Back Pain', 'Cardiac Output, Low-fall-Vision, Low', 'Gout-include-Disease Progression', 'Gout-aggravate-Heart Diseases', 'Gout-increase-Death', 'Renal Artery Obstruction-caused-Atherosclerosis', 'Atherosclerosis-caused-Diabetes Mellitus', 'Atherosclerosis-caused-Arterial Occlusive Diseases', 'Atherosclerosis-caused-Coronary Artery Disease', 'Atherosclerosis-caused-Hypertension', 'Colonic Neoplasms-studied-Neoplasms', 'Hemorrhage-include-Colonic Neoplasms', 'Neoplasms-undergo-Meningeal Neoplasms', 'Colonic Neoplasms-present-Gastrointestinal Hemorrhage', 'Diabetes Mellitus-related-Hepatic Encephalopathy', 'Urinary Retention-investigate-Intervertebral Disc Degeneration', 'Urinary Retention-treated-Infections', 'Osteoarthritis-suffer-Taste Disorders', 'Neurodegenerative Diseases-lead-Nerve Degeneration', 'Anophthalmos-treat-Vision Disorders', 'Meningocele-lead-Nerve Degeneration', 'Colorectal Neoplasms-contribute-Adenocarcinoma', 'Adenocarcinoma-contribute-Neoplasms', 'Death-predicted-Metabolic Syndrome', 'Cardiovascular Diseases-elevated-HIV Infections', 'Neurotoxicity Syndromes-avoid-Brain Injuries', 'Stroke-predisposed-Hypertension', 'Fibrosis-estimated-Fatty Liver', 'Hypotension, Orthostatic-reduce-Syncope', 'Hypotension, Orthostatic-discussed-Hypertension', 'Death-occur-Respiratory Insufficiency', 'Death-occur-Cachexia', 'Peripheral Arterial Disease-predict-Death', 'Peripheral Arterial Disease-lead-Ischemia', 'Peripheral Arterial Disease-lead-Pain', 'Cardiac Output, Low-include-Edema', 'Apnea-progress-Mandibular Nerve Injuries', 'Peripheral Arterial Disease-limited-Cardiovascular Diseases', 'Stomach Neoplasms-correlated-Neoplasms', 'Muscular Dystrophy, Duchenne-develop-LEOPARD Syndrome', 'X-Linked Combined Immunodeficiency Diseases-exhibit-Cardiomyopathies', 'Osteoporosis-review-Renal Insufficiency', 'Osteoporosis-indicate-Renal Insufficiency, Chronic', 'Osteoporosis-diagnose-Renal Insufficiency, Chronic', 'Osteoporosis-characterized-Renal Insufficiency, Chronic', 'Osteoporosis-diagnose-Kidney Diseases', 'Osteoporosis-diagnose-Bone Diseases, Metabolic', 'Heart Failure-associated-Delirium', 'Delirium-associated-Heart Failure', 'Drug Hypersensitivity-characterized-Rhinitis', 'Rhinitis-associated-Chronic Disease', 'Chronic Disease-associated-Rhinitis', 'Rhinitis-associated-Polyps', 'Polyps-associated-Rhinitis', 'Rhinitis-associated-Rhinitis, Vasomotor', 'Rhinitis, Vasomotor-associated-Rhinitis', 'Chronic Disease-caused-Inflammation', 'Muscular Disorders, Atrophic-associated-Chronic Disease', 'Chronic Disease-associated-Muscular Disorders, Atrophic', 'Chronic Disease-associated-Rhinitis, Vasomotor', 'Rhinitis, Vasomotor-associated-Chronic Disease', 'Atherosclerosis-measured-HIV Infections', 'Cross Infection-suffer-Infections', 'Hip Fractures-increase-Myoclonus', 'Death-influenced-Dementia', 'Fatigue-experienced-Chronic Disease', 'Immune System Diseases-implicate-Infections', 'Pulmonary Disease, Chronic Obstructive-describe-Immune System Diseases', 'Infections-become-Pulmonary Arterial Hypertension', 'Pulmonary Arterial Hypertension-lead-Heart Failure', 'Pulmonary Arterial Hypertension-lead-Death', 'Disease Progression-lead-Heart Failure', 'Disease Progression-lead-Death', 'Thrombosis-lead-Venous Thrombosis', 'Thrombosis-lead-Pulmonary Embolism', 'Thrombosis-lead-Myocardial Infarction', 'Thrombosis-lead-Stroke', 'Thrombosis-lead-Death', 'Metabolic Syndrome-verify-Cardiovascular Diseases', 'Metabolic Syndrome-increase-Stroke', 'Metabolic Syndrome-increase-Peripheral Vascular Diseases', 'Carcinoma, Hepatocellular-discriminate-Fibrosis', 'Atherosclerosis-occur-Osteoporotic Fractures', 'Atherosclerosis-suffer-Bone Neoplasms', 'Osteoporotic Fractures-suffer-Bone Neoplasms', 'Osteoporosis-accelerated-Chronic Disease', 'Osteoporosis-accelerated-Neoplasms', 'Chronic Disease-suffer-Tinnitus', 'Inflammation-evaluated-Death', 'Cardiovascular Diseases-strengthen-Inflammation', 'Cardiovascular Diseases-strengthen-Death', 'Peripheral Vascular Diseases-include-Death', 'Hypertension-recognize-Death', 'Heart Diseases-predispose-Hypertension', 'Heart Diseases-predispose-Coronary Artery Disease', 'Pulmonary Disease, Chronic Obstructive-affect-Ossification of Posterior Longitudinal Ligament', 'Cardiac Complexes, Premature-lead-Bradycardia', 'Cardiac Complexes, Premature-lead-Heart Arrest', 'Heart Arrest-followed-Bradycardia', 'Carcinoma, Pancreatic Ductal-differentiated-Pancreatic Neoplasms', 'Muscular Diseases-accelerated-Sarcopenia', 'Heart Failure-sustain-Hip Fractures', 'Stroke-occur-Aneurysm', 'Rupture-occur-Aneurysm, Ruptured', 'Myopia-decrease-Choroid Diseases', 'Osteoporosis-taken-Wounds and Injuries', 'Osteoporosis-taken-Renal Insufficiency, Chronic', 'Atrophy-cause-Xerostomia', 'Stroke-influence-Death', 'Bronchitis-raise-Death', 'Respiratory Tract Diseases-raise-Death', 'Alzheimer Disease-assess-Atrial Fibrillation', 'Alzheimer Disease-identified-Atrial Fibrillation', 'Alzheimer Disease-assess-Hypertension', 'Alzheimer Disease-identified-Hypertension', 'Alzheimer Disease-assess-Angina Pectoris', 'Alzheimer Disease-identified-Angina Pectoris', 'Alzheimer Disease-assess-Myocardial Infarction', 'Alzheimer Disease-identified-Myocardial Infarction', 'Alzheimer Disease-assess-Stroke', 'Alzheimer Disease-identified-Stroke', 'Inflammation-related-HIV Infections', 'Respiratory Tract Infections-followed-Delirium', 'Drug-Related Side Effects and Adverse Reactions-seen-HIV Infections', 'Delirium-cause-Death', 'Osteoporotic Fractures-identified-Infections', 'Fibrosis-predict-Osteoporotic Fractures', 'Acute Kidney Injury-matched-Death', 'Obesity-demonstrate-Acute Kidney Injury', 'Neoplasm Metastasis-confine-Prostatic Neoplasms', 'Neoplasm Metastasis-start-Arthritis, Rheumatoid', 'Neoplasm Metastasis-start-Leukemia', 'Prostatic Neoplasms-start-Arthritis, Rheumatoid', 'Prostatic Neoplasms-start-Leukemia', 'Carotid Stenosis-evaluated-Leukoaraiosis', 'Hyperkinesis-cause-Musculoskeletal Diseases', 'Death-include-Nausea', 'Death-include-Fever', 'Death-include-Abdominal Pain', 'Parkinson Disease-underlie-Brain Diseases, Metabolic', 'Parkinson Disease-persist-Pain', 'Hepatolenticular Degeneration-correspond-Rupture', 'Dementia-contribute-Inflammation', 'Death-increase-Bacteremia', 'Abnormalities, Drug-Induced-increase-Psychoses, Substance-Induced', 'Hypertension-correlated-Obesity', 'Cerebrovascular Trauma-measure-Malformations of Cortical Development', 'Death-screen-Alzheimer Disease', 'Death-screen-Lewy Body Disease', 'Lewy Body Disease-associated-Alzheimer Disease', 'Alzheimer Disease-associated-Lewy Body Disease', 'Lewy Body Disease-associated-Dementia', 'Dementia-associated-Lewy Body Disease', 'Myelodysplastic Syndromes-lead-Hypotension', 'Myelodysplastic Syndromes-suspected-Hematologic Diseases', 'Myelodysplastic Syndromes-needed-Bone Marrow Failure Disorders', 'Hematologic Diseases-needed-Bone Marrow Failure Disorders', 'Muscular Atrophy-termed-Sarcopenia', 'Sarcopenia-termed-Cachexia', 'Metabolic Syndrome-present-Chronic Disease', 'Gallstones-occur-Biliary Fistula', 'Glomerulonephritis-present-Hereditary Breast and Ovarian Cancer Syndrome', 'IgA Vasculitis-change-Kidney Diseases', 'Hereditary Breast and Ovarian Cancer Syndrome-present-Glomerulonephritis', 'Hematuria-present-Glomerulonephritis', 'Diabetes Mellitus-identify-Death', 'Delirium-compare-Pain, Postoperative', 'Central Nervous System Diseases-include-Delirium', 'Atrophy-remain-Alzheimer Disease', 'Death-require-Diabetes Mellitus', 'Leukoaraiosis-suggested-Ischemia', 'Leukoaraiosis-suggested-Arteriolosclerosis', 'Hemophilia A-caused-Wounds and Injuries', 'Hemophilia A-result-Joint Diseases', 'Hemorrhage-caused-Wounds and Injuries', 'Hemorrhage-result-Joint Diseases', 'Wounds and Injuries-result-Joint Diseases', 'Lymphoma-defined-Immunologic Deficiency Syndromes', 'Fatigue-found-Hypotension', 'Hip Fractures-observed-Alzheimer Disease', 'Disorders of Sex Development-suppress-Osteoporotic Fractures', 'Osteoporotic Fractures-associated-Alzheimer Disease', 'Alzheimer Disease-associated-Osteoporotic Fractures', 'Neurologic Manifestations-trigger-Heart Arrest', 'Anemia-combined-Dementia', 'Alzheimer Disease-fit-Nerve Degeneration', 'Death-considered-Neoplasms', 'Death-considered-Cardiovascular Diseases', 'Arterial Occlusive Diseases-considered-Limb Deformities, Congenital', 'Hypoglycemia-associated-Tachycardia', 'Tachycardia-associated-Hypoglycemia', 'Hypoglycemia-associated-Coma', 'Coma-associated-Hypoglycemia', 'Inflammation-associated-Drug Eruptions', 'Drug Eruptions-associated-Inflammation', 'Inflammation-associated-Skin Diseases, Eczematous', 'Skin Diseases, Eczematous-associated-Inflammation', 'Inflammation-associated-Dermatitis', 'Dermatitis-associated-Inflammation', 'Cholecystitis, Acute-resolve-Death', 'Hypotension-increase-Coronary Artery Disease', 'Brain Injuries-exacerbate-Craniocerebral Trauma', 'Gastrointestinal Hemorrhage-increase-Kidney Diseases', 'Alzheimer Disease-render-Dementia', 'Muscular Diseases-used-Fasciculation', 'Sarcopenia-accelerate-Renal Insufficiency, Chronic', 'Sarcopenia-appear-Muscular Atrophy', 'Muscular Atrophy-accelerate-Renal Insufficiency, Chronic', 'Sarcopenia-appear-Acidosis', 'Muscular Atrophy-appear-Communicable Diseases', 'Muscular Atrophy-appear-Acidosis', 'Communicable Diseases-appear-Acidosis', 'Sarcopenia-present-Muscular Atrophy', 'Hirsutism-decrease-Acne Vulgaris', 'Kidney Diseases-lead-Cardiovascular Diseases', 'Polycystic Ovary Syndrome-based-Hyperandrogenism', 'Polycystic Ovary Syndrome-based-Amenorrhea', 'Arthritis-wound-Infections', 'Muscular Diseases-characterized-Contracture', 'Muscular Diseases-characterized-Heart Diseases', 'Heredodegenerative Disorders, Nervous System-cause-Nerve Degeneration', 'Growth Disorders-associated-Calcinosis', 'Calcinosis-associated-Growth Disorders', 'Cachexia-marked-Neoplasms', 'Cachexia-associated-Calcinosis', 'Calcinosis-associated-Cachexia', 'Aneurysm-marked-Neoplasms', 'Aneurysm-associated-Calcinosis', 'Calcinosis-associated-Aneurysm', 'Exocrine Pancreatic Insufficiency-associated-Calcinosis', 'Calcinosis-associated-Exocrine Pancreatic Insufficiency', 'Bone Diseases, Metabolic-associated-Calcinosis', 'Calcinosis-associated-Bone Diseases, Metabolic', 'Neoplasms-associated-Calcinosis', 'Calcinosis-associated-Neoplasms', 'Neurodegenerative Diseases-associated-Calcinosis', 'Calcinosis-associated-Neurodegenerative Diseases', 'Osteoporosis-followed-Fractures, Bone', 'Osteoporosis-followed-Death', 'Brain Neoplasms-occur-Epilepsy', 'Migraine Disorders-occur-Epilepsy', 'Stroke-occur-Epilepsy', 'Brain Injuries, Traumatic-occur-Epilepsy', 'Diabetes Mellitus, Type 2-show-Dyslipidemias', 'Parkinson Disease-show-Dyslipidemias', 'Arthritis-predict-Hip Fractures', 'Tooth, Impacted-increase-Asthma', 'Heart Failure-become-Hypertension, Pulmonary', 'Death-accompany-Inflammation', 'Alzheimer Disease-observed-Glucose Metabolism Disorders', 'Death-predispose-Arrhythmias, Cardiac', 'Atrial Fibrillation-facilitated-Atrial Remodeling', 'Atrial Fibrillation-facilitated-Atrial Premature Complexes', 'Heredodegenerative Disorders, Nervous System-include-Wounds and Injuries', 'Heredodegenerative Disorders, Nervous System-induced-Wounds and Injuries', 'Disease Progression-range-Calcinosis', 'Aortic Valve Stenosis-present-Atherosclerosis', 'Aortic Diseases-known-Calcinosis', 'Death-demonstrate-Dystonia', 'Motor Neuron Disease-explored-Nervous System Diseases', 'Anorexia-play-Sarcopenia', 'Bruxism-found-Sleep Wake Disorders', 'Idiopathic Pulmonary Fibrosis-appear-Lung Neoplasms', 'Idiopathic Pulmonary Fibrosis-use-Lung Neoplasms', 'Communicable Diseases-generate-Sleep Initiation and Maintenance Disorders', 'Heart Diseases-contribute-Heart Failure', 'Rheumatic Heart Disease-contribute-Heart Failure', 'Thromboembolism-represent-Hemorrhage', 'Aortic Arch Syndromes-represent-Atherosclerosis', 'Anemia, Megaloblastic-lead-Cardiovascular Diseases', 'Anemia, Megaloblastic-lead-Dementia', 'Infections-develop-Respiratory Distress Syndrome', 'Atrophy-base-Alzheimer Disease', 'Sepsis-lead-Death', 'Cockayne Syndrome-characterized-Nervous System Malformations', 'Shy-Drager Syndrome-characterized-Nervous System Malformations', 'Chemical and Drug Induced Liver Injury-prevent-Death', 'Kidney Diseases-occluded-Plaque, Atherosclerotic', 'Kidney Diseases-occluded-Aortic Arch Syndromes', 'Renal Artery Obstruction-account-Renal Insufficiency, Chronic', 'Arterial Occlusive Diseases-caused-Thrombosis', 'Leriche Syndrome-refer-Thrombosis', 'Leriche Syndrome-manifest-Renal Insufficiency, Chronic', 'Takotsubo Cardiomyopathy-include-Shock', 'Takotsubo Cardiomyopathy-include-Arrhythmias, Cardiac', 'Cockayne Syndrome-characterized-Shy-Drager Syndrome', 'Cockayne Syndrome-classified-Aging, Premature', 'Shy-Drager Syndrome-characterized-Aging, Premature', 'Bronchopulmonary Dysplasia-develop-Pulmonary Disease, Chronic Obstructive', 'Pulmonary Disease, Chronic Obstructive-reduce-Death', 'Hypoxia-reduce-Death', 'Pulmonary Disease, Chronic Obstructive-improve-Death', 'Kidney Diseases, Cystic-resemble-Pancreatic Intraductal Neoplasms', 'Infections-challenge-Leukemia, Myeloid, Acute', 'Shock, Septic-show-Death', 'Shock, Septic-show-Infections', 'Alzheimer Disease-begin-Death', 'Alzheimer Disease-culminate-Neurodegenerative Diseases', 'Death-culminate-Neurodegenerative Diseases', 'Osteoarthritis-associated-Osteoporosis', 'Osteoporosis-associated-Osteoarthritis', 'Stroke-related-Brain Edema', 'Edema-suggest-Enteritis', 'Hypertension, Pulmonary-take-Airway Obstruction', 'Erythema-suggest-Enteritis', 'Hypertension, Pulmonary-admitted-Gastrointestinal Hemorrhage', 'Airway Obstruction-admitted-Gastrointestinal Hemorrhage', 'Stroke-described-Muscular Diseases', 'Stroke-described-Muscular Disorders, Atrophic', 'Median Arcuate Ligament Syndrome-suggest-Enteritis', 'Muscular Diseases-described-Muscular Disorders, Atrophic', 'Hemophilia A-cause-Hemorrhage', 'Deglutition Disorders-identify-Pneumonia, Aspiration', 'Hemophilia A-used-Joint Diseases', 'Joint Diseases-lead-Hemophilia A', 'Diabetes Mellitus, Type 2-rise-Dementia', 'Alzheimer Disease-examine-Basal Ganglia Diseases', 'Neoplasms-range-Melanoma', 'Myelodysplastic Syndromes-related-Neoplasms', 'Fractures, Bone-reflect-Osteoporosis', 'Fractures, Bone-expressed-Death', 'Drug Eruptions-range-Exanthema', 'Death-associated-Drug Eruptions', 'Drug Eruptions-associated-Death', 'Hypoxia-utilize-Neoplasms', 'Hypoxia-follow-Neoplasms', 'Anemia-explore-Cardiovascular Diseases', 'Diabetes Mellitus-explore-Cardiovascular Diseases', 'Hypoxia-evaluate-Neoplasms', 'Anemia-associate-Kidney Diseases', 'Kidney Diseases-associate-Anemia', 'Anemia-associate-Proteinuria', 'Proteinuria-associate-Anemia', 'Coronary Artery Disease-associated-Anemia', 'Anemia-associated-Coronary Artery Disease', 'Cardiac Output, Low-derived-Dyssomnias', 'Psychoses, Substance-Induced-increase-Death', 'Obesity-contribute-Neoplasms', 'Inflammation-lead-Pyelonephritis', 'Neck Pain-present-Spinal Cord Diseases', 'Headache-present-Spinal Cord Diseases', 'Wounds and Injuries-identified-Malocclusion', 'HIV Infections-compared-Neoplasms', 'Scoliosis-considered-Musculoskeletal Diseases', 'Breast Neoplasms-include-Adenocarcinoma', 'Peripheral Arterial Disease-underlie-Calcinosis', 'Calcinosis-increasing-Carotid Artery Diseases', 'Peripheral Arterial Disease-present-Intermittent Claudication', 'Peripheral Arterial Disease-present-Ischemia', 'Peripheral Arterial Disease-decrease-Barotrauma', 'Fractures, Bone-attributed-Calcinosis', 'Peripheral Arterial Disease-attributed-Calcinosis', 'Peripheral Arterial Disease-attributed-Fibrosis', 'Asthma-characterised-Rhinitis, Allergic', 'Death-reduce-Tuberculosis', 'Stroke-link-Dementia', 'Coronary Artery Disease-link-Dementia', 'Polycystic Ovary Syndrome-characterized-Ovarian Diseases', 'Polycystic Ovary Syndrome-treated-Infertility, Female', 'Polycystic Ovary Syndrome-treated-Ovarian Diseases', 'Infertility, Female-treated-Ovarian Diseases', 'Neoplasms-extracted-Esophageal Neoplasms', 'Hemorrhagic Disorders-follow-Craniocerebral Trauma', 'Stroke-follow-Craniocerebral Trauma', 'Retinal Degeneration-follow-Craniocerebral Trauma', 'Dementia-follow-Craniocerebral Trauma', 'Ulcer-found-Nausea', 'Hemorrhage-include-Peptic Ulcer', 'Hypertension-ameliorate-Brain Diseases', 'Death-contribute-Ventricular Dysfunction, Left', 'Death-contribute-Kidney Diseases', 'Papillon-Lefevre Disease-characterized-Keratoderma, Palmoplantar', 'Papillon-Lefevre Disease-characterized-Periodontitis', 'Genetic Diseases, Inborn-characterized-Keratoderma, Palmoplantar', 'Genetic Diseases, Inborn-characterized-Periodontitis', 'Hypogonadism-associated-Sexual Dysfunction, Physiological', 'Sexual Dysfunction, Physiological-associated-Hypogonadism', 'Hypogonadism-associated-Erectile Dysfunction', 'Erectile Dysfunction-associated-Hypogonadism', 'Pain-live-Neoplasms', 'Inflammation-reflect-Pruritus', 'Mitochondrial Diseases-demonstrated-Neurodegenerative Diseases', 'Mitochondrial Diseases-demonstrated-Alzheimer Disease', 'Mitochondrial Diseases-demonstrated-Parkinson Disease', 'Mitochondrial Diseases-demonstrated-Amyotrophic Lateral Sclerosis', 'Mitochondrial Diseases-demonstrated-Neoplasms', 'Pulmonary Disease, Chronic Obstructive-affected-Inflammation', 'Airway Obstruction-associated-Inflammation', 'Inflammation-associated-Airway Obstruction', 'Cardiovascular Diseases-compare-Dementia', 'Stroke-compare-Dementia', 'Aneuploidy-recognized-Neoplasms', 'Venous Thromboembolism-stemm-Cardiovascular Diseases', 'Death-stemm-Cardiovascular Diseases', 'Wounds and Injuries-considered-Urinary Incontinence, Stress', 'Muscle Weakness-considered-Urinary Incontinence, Stress', 'Gait Disorders, Neurologic-designate-Musculoskeletal Diseases', 'Back Pain-show-Gait Disorders, Neurologic', 'Back Pain-associated-Gait Disorders, Neurologic', 'Gait Disorders, Neurologic-associated-Back Pain', 'Ankle Fractures-evaluate-Osteoporosis', 'Fractures, Bone-managed-Uterine Cervicitis', 'Coronary Artery Disease-treat-Stroke', 'Coronary Artery Disease-treat-Atrial Fibrillation', 'Coronary Artery Disease-evaluated-Hemorrhage', 'Coronary Artery Disease-treat-Hemorrhage', 'Coronary Artery Disease-evaluated-Neoplasms', 'Stroke-evaluated-Hemorrhage', 'Stroke-evaluated-Neoplasms', 'Atrial Fibrillation-evaluated-Hemorrhage', 'Atrial Fibrillation-evaluated-Neoplasms', 'Colorectal Neoplasms-compared-Neoplasms', 'Colorectal Neoplasms-increased-Constipation', 'Parental Death-related-Acquired Immunodeficiency Syndrome', 'Asphyxia-caused-Hemorrhage', 'Fractures, Bone-occur-Hemorrhage', 'Airway Obstruction-result-Asphyxia', 'Hemorrhage-result-Asphyxia', 'Airway Obstruction-caused-Hemorrhage', 'Asthma-exist-Airway Obstruction', 'Glucose Metabolism Disorders-extracted-Alzheimer Disease', 'Neurodegenerative Diseases-indicate-Alzheimer Disease', 'Chronic Disease-coexist-Heart Failure', 'Lung Neoplasms-decrease-Death', 'Glucosephosphate Dehydrogenase Deficiency-selected-Malaria', 'Glucosephosphate Dehydrogenase Deficiency-confer-Neoplasms', 'Malaria-confer-Neoplasms', 'Ischemia-measured-Brain Infarction', 'Mitochondrial Diseases-recognized-Endocrine System Diseases', 'Cardiovascular Diseases-increased-Inflammation', 'Inflammation-implicated-Bone Diseases', 'Kidney Diseases-accumulate-Drug-Related Side Effects and Adverse Reactions', 'Fibrosis-develop-Genetic Diseases, Inborn', 'Tuberculosis, Urogenital-associated-Acquired Immunodeficiency Syndrome', 'Acquired Immunodeficiency Syndrome-associated-Tuberculosis, Urogenital', 'Genetic Diseases, Inborn-lead-Respiratory Distress Syndrome', 'Wounds and Injuries-lead-Respiratory Distress Syndrome', 'Tuberculosis, Urogenital-occur-Pyuria', 'Respiratory Tract Infections-suspected-Tuberculosis, Urogenital', 'Respiratory Tract Infections-suspected-Infections', 'Tuberculosis, Urogenital-suspected-Infections', 'Hypophosphatemia-develop-Fanconi Anemia', 'Inflammation-play-Pigmentation Disorders', 'Neoplasms-reported-Carcinogenesis', 'Thrombosis-seem-Hemorrhage', 'Thrombophlebitis-described-von Willebrand Diseases', 'Thrombosis-described-von Willebrand Diseases', 'Pulmonary Embolism-described-von Willebrand Diseases', 'Hematologic Diseases-registrated-Lupus Erythematosus, Systemic', 'Diabetes Mellitus-evaluate-Dementia', 'Diabetes Mellitus-hear-Vision Disorders', 'Hyponatremia-contribute-Delirium', 'Cataract-diagnose-Glaucoma', 'Neurodegenerative Diseases-characterized-Death', 'Neurodegenerative Diseases-characterized-Paralysis', 'Chronic Disease-help-Seizures', 'Inflammation-evidence-Neoplasms', 'Inflammation-evidence-Infections', 'Inflammation-reduce-Kidney Failure, Chronic', 'Atrophy-relate-Alzheimer Disease', 'Cataract-associated-Rheumatic Diseases', 'Rheumatic Diseases-associated-Cataract', 'Cardiovascular Diseases-associated-Rheumatic Diseases', 'Rheumatic Diseases-associated-Cardiovascular Diseases', 'Hemorrhage-confirm-Anemia', 'Hemorrhage-confirm-Respiratory Insufficiency', 'Rheumatic Diseases-correlated-Cardiovascular Diseases', 'Rheumatic Diseases-correlated-Cataract', 'Rheumatic Diseases-correlated-Pain', 'Neoplasms-select-Fatigue', 'Neoplasms-followed-Fatigue', 'Lung Neoplasms-followed-Fatigue', 'Venous Thromboembolism-indicate-Venous Thrombosis', 'Venous Thromboembolism-indicate-Pulmonary Embolism', 'Diabetes Mellitus-drive-Inflammation', 'Hypertension-drive-Inflammation', 'Hyperlipidemias-drive-Inflammation', 'Uremia-drive-Inflammation', 'Pneumonia-followed-Urinary Tract Infections', 'Diabetes Mellitus-followed-Urinary Tract Infections', 'Pulmonary Disease, Chronic Obstructive-followed-Urinary Tract Infections', 'Progeria-share-Atherosclerosis', 'Progeria-share-Nerve Degeneration', 'Progeria-share-Neoplasms', 'Hemophilia A-confronted-Coronary Artery Disease', 'Hepatolenticular Degeneration-decrease-Infections', 'Breast Neoplasms-separated-Death', 'Death-separated-Breast Neoplasms', 'Death-mediated-Aortic Diseases', 'Metabolic Syndrome-linked-Dementia, Vascular', 'Parkinson Disease-directed-Neurodegenerative Diseases', 'Anastomotic Leak-correlated-Death', 'Arthritis-sustain-Surgical Wound Infection', 'Cerebral Infarction-classified-Stroke', 'Atrial Fibrillation-account-Cerebral Infarction', 'Stroke-become-Cerebral Infarction', 'Lung Neoplasms-permit-Neoplasms', 'Headache Disorders, Secondary-reproduce-Syncope, Vasovagal', 'Osteoporotic Fractures-predispose-Heart Failure', 'Osteoporotic Fractures-predispose-Oculocerebrorenal Syndrome', 'Squamous Cell Carcinoma of Head and Neck-include-Neoplasms', 'Neoplasms-include-Squamous Cell Carcinoma of Head and Neck', 'Squamous Cell Carcinoma of Head and Neck-include-Death', 'Squamous Cell Carcinoma of Head and Neck-represent-Death', 'Renal Insufficiency, Chronic-suffer-Vascular Calcification', 'Vascular Calcification-lead-Death', 'Cushing Syndrome-contribute-Vascular Calcification', 'Osteoarthritis-complete-Pain', 'Glaucoma-include-Anophthalmos', 'Retinal Vein Occlusion-include-Anophthalmos', 'Death-affected-Dementia', 'Neurodegenerative Diseases-relate-Alzheimer Disease', 'Epilepsy-considered-Communicable Diseases', 'Epilepsy-consider-Poisoning', 'Respiratory Tract Infections-account-End Stage Liver Disease', 'Adrenal Insufficiency-explain-Periodontitis', 'Adrenal Insufficiency-explain-Tooth Loss', 'Diabetes Mellitus-develop-Alzheimer Disease', 'Diabetes Mellitus-develop-Dementia, Vascular', 'Consciousness Disorders-impair-Stroke', 'Dementia-reported-Stroke', 'Neurologic Manifestations-caused-Chronic Disease', 'Neurologic Manifestations-caused-Myocardial Infarction', 'Diabetic Neuropathies-lead-Hypotension', 'Coronary Artery Disease-show-Gray Platelet Syndrome', 'Heart Failure-show-Gray Platelet Syndrome', 'Sarcopenia-define-Myalgia', 'Death-tend-Infections', 'Death-tend-Arbovirus Infections', 'Arbovirus Infections-tend-Infections', 'Metabolic Syndrome-tend-Diabetes Mellitus', 'Sleep Wake Disorders-associated-Cerebrovascular Disorders', 'Cerebrovascular Disorders-associated-Sleep Wake Disorders', 'Cerebrovascular Disorders-associated-Sleep Initiation and Maintenance Disorders', 'Sleep Initiation and Maintenance Disorders-associated-Cerebrovascular Disorders', 'Sleep Initiation and Maintenance Disorders-appear-Sleep Wake Disorders', 'Cerebrovascular Disorders-appear-Sleep Wake Disorders', 'Sleep Wake Disorders-detect-Cerebrovascular Disorders', 'Dementia-enrolled-Pain', 'Pain-re-assess-Dementia', 'Osteoporosis-prevent-Vascular Calcification', 'Diabetes Mellitus-associated-Arthritis', 'Arthritis-associated-Diabetes Mellitus', 'Neoplasms-associated-Arthritis', 'Arthritis-associated-Neoplasms', 'Leukoencephalopathies-linked-Hypertension', 'Synovitis-treat-Arthritis, Rheumatoid', 'Emphysema-associated-Stroke', 'Stroke-associated-Emphysema', 'Emphysema-involve-Lung Diseases', 'Death-differ-Arrhythmias, Cardiac', 'Hemophilia A-protected-Cardiovascular Diseases', 'Retroperitoneal Neoplasms-caused-Wounds and Injuries', 'Retroperitoneal Neoplasms-caused-Wounds, Nonpenetrating', 'Retroperitoneal Neoplasms-cause-Wounds and Injuries', 'Neoplasms-improve-Myelodysplastic Syndromes', 'Myelodysplastic Syndromes-associated-Leukemia, Myeloid, Acute', 'Leukemia, Myeloid, Acute-associated-Myelodysplastic Syndromes', 'Leukemia, Myeloid-associated-Leukemia, Myeloid, Acute', 'Leukemia, Myeloid, Acute-associated-Leukemia, Myeloid', 'Death-related-Myelodysplastic Syndromes', 'Death-underestimated-Neoplasms', 'Death-based-Neoplasms', 'Myelodysplastic Syndromes-missed-Death', 'Death-diagnosed-Myelodysplastic Syndromes', 'Death-coded-Leukemia, Myeloid, Acute', 'Leukemia-coded-Leukemia, Myeloid, Acute', 'Death-coded-Leukemia', 'Death-included-Leukemia', 'Myelodysplastic Syndromes-coded-Leukemia, Myeloid, Acute', 'Death-included-Myelodysplastic Syndromes', 'Death-included-Neoplasms', 'Leukemia-included-Neoplasms', 'Leukemia-included-Death', 'Myelodysplastic Syndromes-included-Neoplasms', 'Myelodysplastic Syndromes-included-Death', 'Death-added-Myelodysplastic Syndromes', 'Neoplasms-confirm-Leukemia', 'Neoplasms-coded-Death', 'Leukemia-coded-Death', 'Leukemia-help-Death', 'Death-adjusted-Chronic Disease', 'Death-seen-Pneumococcal Infections', 'Cytomegalovirus Infections-increase-Death', 'Lung Injury-include-Hyperoxia', 'Cardiomyopathies-include-Hyperoxia', 'Pulmonary Disease, Chronic Obstructive-associated-Emphysematous Cholecystitis', 'Emphysematous Cholecystitis-associated-Pulmonary Disease, Chronic Obstructive', 'Pain-associated-Deafness', 'Deafness-associated-Pain', 'Weight Loss-randomized-Hypertension', 'Carcinogenesis-detect-Ovarian Neoplasms', 'Hematologic Diseases-include-Leukemia, Myelomonocytic, Chronic', 'Hematologic Diseases-include-Leukemia, Myeloid, Acute', 'Hematologic Diseases-include-Myelodysplastic Syndromes', 'Hematologic Diseases-include-Eosinophilia', 'Hematologic Diseases-include-Primary Myelofibrosis', 'Hematologic Diseases-include-Myeloproliferative Disorders', 'Hematologic Diseases-include-Multiple Myeloma', 'Hematologic Diseases-include-Lymphoma, B-Cell', 'Hematologic Diseases-precede-Mastocytosis, Systemic', 'Hematologic Diseases-include-Thrombocytopenia', 'Carcinoma, Merkel Cell-control-Neoplasms', 'Lipoma-see-Stomach Neoplasms', 'Neoplasms-see-Lipoma', 'Neoplasms-see-Stomach Neoplasms', 'Pain-fall-Ulcer', 'Stroke-predispose-Epilepsy', 'Dementia-predispose-Epilepsy', 'Inflammation-involved-Dry Eye Syndromes', 'Multiple Organ Failure-present-Death', 'Hypertension-associated-Heart Failure, Diastolic', 'Heart Failure, Diastolic-associated-Hypertension', 'Death-caused-Pulmonary Valve Insufficiency', 'Alzheimer Disease-refer-Postoperative Cognitive Complications', 'Delirium-associated-Lung Diseases', 'Lung Diseases-associated-Delirium', 'Primary Ovarian Insufficiency-mimic-Polycystic Ovary Syndrome', 'Primary Ovarian Insufficiency-arise-Hyperandrogenism', 'Polycystic Ovary Syndrome-arise-Hyperandrogenism', 'Pyelonephritis-manage-Bacteremia', 'Drug-Related Side Effects and Adverse Reactions-induced-Arbovirus Infections', 'Brain Injuries-occur-Alzheimer Disease', 'Hypertension-occur-Coronary Artery Disease', 'Hypertension-suffer-Pulmonary Disease, Chronic Obstructive', 'Coronary Artery Disease-suffer-Pulmonary Disease, Chronic Obstructive', 'Pain-relieve-Joint Diseases', 'Glioblastoma-lead-Dementia', 'Metabolic Diseases-understood-Dementia', 'Anorexia-represent-Death', 'Spondylosis-affect-Sensation Disorders', 'Pain-include-Osteoporotic Fractures', 'Osteoporotic Fractures-include-Kyphosis', 'Death-include-Osteoporotic Fractures', 'Ulcer-need-Gastrointestinal Hemorrhage', 'Thyroid Neoplasms-use-Neoplasms', 'Skin Neoplasms-include-Photosensitivity Disorders', 'Migraine Disorders-linked-Stroke', 'Migraine Disorders-linked-Brain Diseases', 'Stroke-associated-Brain Diseases', 'Brain Diseases-associated-Stroke', 'Intestinal Diseases-reviewed-Pain', 'Intestinal Diseases-reviewed-Hemorrhage', 'Intestinal Diseases-reviewed-Short Bowel Syndrome', 'Memory Disorders-include-Neurodegenerative Diseases', 'Cerebrovascular Trauma-understand-Alzheimer Disease', 'Infections-use-Fistula', 'Sepsis-lie-Infections', 'Pulmonary Disease, Chronic Obstructive-worsen-Inflammation', 'Inflammation-associated-Lung Neoplasms', 'Lung Neoplasms-associated-Inflammation', 'Inflammation-become-Pulmonary Disease, Chronic Obstructive', 'Pulmonary Disease, Chronic Obstructive-become-Inflammation', 'Inflammation-develop-Pulmonary Disease, Chronic Obstructive', 'Fatigue Syndrome, Chronic-demonstrate-Fatigue', 'Death-diagnosed-Dementia', 'Dementia-made-Learning Disabilities', 'Obesity-contribute-Diabetes Mellitus, Type 2', 'Obesity-considered-Diabetes Mellitus, Type 2', 'Stroke, Lacunar-lead-Seizures', 'Stroke, Lacunar-lead-Gait Apraxia', 'Stroke, Lacunar-lead-Vertigo', 'Stroke, Lacunar-lead-Urinary Incontinence', 'Stroke, Lacunar-seen-Gait Apraxia', 'Stroke, Lacunar-seen-Vertigo', 'Stroke, Lacunar-seen-Urinary Incontinence', 'Obesity-related-Cerebral Hemorrhage', 'Cerebral Infarction-related-Cerebral Hemorrhage', 'Diabetes Mellitus, Type 2-avoided-Hypoglycemia', 'Diabetes Mellitus-avoided-Hypoglycemia', 'Diabetes Mellitus-lose-Dementia', 'Neutropenia-followed-Leukopenia', 'Drug-Related Side Effects and Adverse Reactions-followed-Leukopenia', 'Sleep Initiation and Maintenance Disorders-measured-Sleep Wake Disorders', 'Sleep Initiation and Maintenance Disorders-compare-Sleep Wake Disorders', 'Heart Failure-compare-Sleep Wake Disorders', 'Fractures, Bone-follow-Spinal Cord Injuries', 'Arrhythmias, Cardiac-examined-Fractures, Bone', 'Renal Insufficiency, Chronic-seen-Hyperuricemia', 'Renal Insufficiency, Chronic-seen-Gout', 'Heart Failure-become-Muscle Weakness', 'Cancer Pain-associated-Rheumatic Diseases', 'Rheumatic Diseases-associated-Cancer Pain', 'Cytomegalovirus Infections-associated-Chronic Disease', 'Chronic Disease-associated-Cytomegalovirus Infections', 'Cancer Pain-cause-Neoplasms', 'Pain-cause-Neoplasms', 'Leptospirosis-caused-Ascariasis', 'Death-adjusted-Sepsis', 'Fatigue-demonstrate-Myotonia', 'Brain Damage, Chronic-associated-Ischemia', 'Ischemia-associated-Brain Damage, Chronic', 'Neurodegenerative Diseases-associated-Ischemia', 'Ischemia-associated-Neurodegenerative Diseases', 'Sleep Initiation and Maintenance Disorders-observed-Neurodegenerative Diseases', 'Dementia-observed-Neurodegenerative Diseases', 'Hypothyroidism-develop-Communicable Diseases', 'Heart Defects, Congenital-include-Mitral Valve Stenosis', 'Seizures-assess-Alzheimer Disease', 'Parkinson Disease-mirrored-Nerve Degeneration', 'Parkinson Disease-fail-Communicable Diseases', 'Cerebral Hemorrhage-implicated-Cerebral Amyloid Angiopathy', 'Basal Ganglia Cerebrovascular Disease-implicated-Cerebral Amyloid Angiopathy', 'Diabetes Mellitus, Type 2-associated-Osteoporosis', 'Osteoporosis-associated-Diabetes Mellitus, Type 2', 'Chromosome Aberrations-involved-Liver Cirrhosis, Biliary', 'Chromosome Aberrations-manifest-Liver Cirrhosis, Biliary', 'Brain Injuries, Traumatic-result-Alzheimer Disease', 'Brain Injuries, Traumatic-met-Alzheimer Disease', 'Neurologic Manifestations-associated-Dementia', 'Dementia-associated-Neurologic Manifestations', 'Paresis-noted-Deglutition Disorders', 'Deglutition Disorders-noted-Facial Nerve Diseases', 'Sleep Initiation and Maintenance Disorders-assess-Neurologic Manifestations', 'Neurologic Manifestations-mediate-Sleep Initiation and Maintenance Disorders', 'Hypothyroidism-associated-Thyroid Diseases', 'Thyroid Diseases-associated-Hypothyroidism', 'Hyperthyroidism-associated-Thyroid Diseases', 'Thyroid Diseases-associated-Hyperthyroidism', 'Hypothyroidism-associated-Heart Failure', 'Heart Failure-associated-Hypothyroidism', 'Seizures-classified-Epilepsy', 'Hyperthyroidism-associated-Coronary Artery Disease', 'Coronary Artery Disease-associated-Hyperthyroidism', 'Hyperthyroidism-associated-Heart Failure', 'Heart Failure-associated-Hyperthyroidism', 'Hyperpigmentation-include-Glaucoma, Open-Angle', 'Muscular Diseases-contribute-Fatigue', 'Vision Disorders-contribute-Heart Failure', 'Vision Disorders-contribute-Fatigue', 'Heart Failure-contribute-Fatigue', 'Heart Failure-contribute-Dyspnea', 'Muscular Diseases-observed-Heart Diseases', 'Heart Failure-show-Fasciculation', 'Heart Failure-show-Atrophy', 'Sarcopenia-induce-Muscular Diseases', 'Sarcopenia-amplified-Weight Loss', 'Sarcopenia-involved-Anorexia', 'Cachexia-induce-Muscular Diseases', 'Cachexia-amplified-Weight Loss', 'Muscular Diseases-induce-Anorexia', 'Weight Loss-amplified-Anorexia', 'Tremor-understand-Neuromuscular Diseases', 'Cerebral Amyloid Angiopathy-examine-Death', 'Arteriolosclerosis-examine-Death', 'Headache-attributed-Epilepsy', 'Arteriolosclerosis-show-Death', 'Epilepsy-attributed-Tension-Type Headache', 'Hematoma-reduce-Fractures, Bone', 'Death-related-Acute Coronary Syndrome', 'Cardiomyopathy, Hypertrophic-involve-Sotos Syndrome', 'Immunologic Deficiency Syndromes-associated-Fractures, Bone', 'Fractures, Bone-associated-Immunologic Deficiency Syndromes', 'Immunologic Deficiency Syndromes-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-Immunologic Deficiency Syndromes', 'Immunologic Deficiency Syndromes-associated-Obesity', 'Obesity-associated-Immunologic Deficiency Syndromes', 'Immunologic Deficiency Syndromes-associated-Tuberculosis', 'Tuberculosis-associated-Immunologic Deficiency Syndromes', 'Obesity-diagnosed-Hypertension', 'Breast Neoplasms-follow-Weight Gain', 'Breast Neoplasms-follow-Thromboembolism', 'HIV Infections-marked-Atrophy', 'Diabetic Nephropathies-include-Renal Insufficiency, Chronic', 'Breast Neoplasms-tend-Cardiovascular Diseases', 'Breast Neoplasms-arise-Cardiovascular Diseases', 'Breast Neoplasms-burdened-Cardiovascular Diseases', 'Hemophilia A-complicated-Joint Diseases', 'Polymyalgia Rheumatica-relieve-Pain', 'Hemophilia A-relieve-Pain', 'Death, Sudden, Cardiac-prevent-Heart Diseases', 'Death, Sudden, Cardiac-prevent-Heart Failure', 'Cystitis-linked-Kidney Diseases', 'Cystitis-linked-Hematologic Diseases', 'Cystitis-linked-Autoimmune Diseases', 'Skin Diseases-characterized-Neoplasms', 'Werner Syndrome-exhibit-Chondrosarcoma', 'Death-survive-Dementia', 'Death-reanalyzed-Neoplasms', 'Urologic Neoplasms-lead-Neoplasms', 'Osteomalacia-prevent-Bone Diseases', 'Osteoporotic Fractures-occur-Obesity', 'Delirium-distinguish-Dementia', 'Colitis, Ischemic-account-Gastrointestinal Hemorrhage', 'Colitis, Ischemic-recommended-Abdominal Pain', 'Colitis, Ischemic-presenting-Abdominal Pain', 'Colitis, Ischemic-recommended-Hemorrhage', 'Colitis, Ischemic-presenting-Hemorrhage', 'Substance-Related Disorders-influence-Pain', 'Mouth Diseases-present-Hyperplasia', 'Mouth Diseases-present-Carcinoma, Squamous Cell', 'Hip Fractures-fall-Osteoporosis', 'Retinal Vein Occlusion-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-Retinal Vein Occlusion', "Sjogren's Syndrome-characterized-Inflammation", 'Dry Eye Syndromes-set-Keratoconjunctivitis Sicca', 'Dry Eye Syndromes-combine-Keratoconjunctivitis Sicca', 'Dry Eye Syndromes-set-Salivary Gland Diseases', 'Dry Eye Syndromes-combine-Salivary Gland Diseases', "Sjogren's Syndrome-characterized-Xerostomia", 'Xerostomia-set-Keratoconjunctivitis Sicca', 'Xerostomia-combine-Keratoconjunctivitis Sicca', 'Xerostomia-set-Salivary Gland Diseases', 'Xerostomia-combine-Salivary Gland Diseases', "Sjogren's Syndrome-characterized-Keratoconjunctivitis Sicca", 'Autoimmune Diseases-characterized-Xerostomia', 'Autoimmune Diseases-characterized-Keratoconjunctivitis Sicca', 'Carcinoma, Pancreatic Ductal-benefit-Death', 'Sexually Transmitted Diseases-believed-Infections', 'Werner Syndrome-characterize-Cataract', 'Hyperplasia-suppress-Wounds and Injuries', 'Hyperplasia-exhibit-Wounds and Injuries', 'Oculocerebrorenal Syndrome-suffer-Osteoporosis', 'Acute Coronary Syndrome-increase-Gastrointestinal Hemorrhage', 'Acute Coronary Syndrome-increase-Mucositis', 'Peptic Ulcer-play-Gastrointestinal Hemorrhage', 'Myopia-correlate-Cataract', 'Myopia-correlate-Hyperopia', 'Cataract-correlate-Hyperopia', 'Anisometropia-correlate-Cataract', 'Multiple Myeloma-control-Amyloidosis', 'Fractures, Bone-occur-Cardiac Output, Low', 'Neurilemmoma-demonstrate-Neoplasms', 'Hypertension-result-Nocturia', 'Hypertension-complicate-Heart Failure', 'Heart Failure-complicate-Edema', 'Sarcopenia-evaluate-Death', 'Neoplasms-include-Abdominal Pain', 'Neoplasms-include-Weight Loss', 'Anorexia-follow-Memory Disorders', 'Lupus Erythematosus, Systemic-registered-Catastrophic Illness', 'Death-diagnosed-Lupus Erythematosus, Systemic', 'Alzheimer Disease-weaken-Atrophy', 'Seizures-observed-Status Epilepticus', 'Neurologic Manifestations-implicated-Alzheimer Disease', 'Hypercalcemia-cause-Hyperparathyroidism', 'Inflammation-tend-Colitis, Ulcerative', 'Inflammation-subside-Colitis, Ulcerative', 'Infarction-seen-Stroke', 'Infarction-seen-Ischemia', 'Plaque, Atherosclerotic-range-Rupture', 'Colorectal Neoplasms-diagnose-Neoplasms', 'Glomerulonephritis-occur-Respiratory Tract Infections', 'Alzheimer Disease-involve-Dementia', 'Inflammation-reduce-Colitis', 'Neoplasms-reduce-Multiple Myeloma', 'Genetic Diseases, Inborn-characterized-Aneuploidy', 'Aneuploidy-show-Neoplasms', 'Atrial Fibrillation-assessed-Hemorrhage', 'Stroke-conferred-Atrial Fibrillation', 'Stroke-come-Hemorrhage', 'Atrial Fibrillation-balance-Stroke', 'Osteoporosis-heard-Pain', 'Osteoporosis-heard-Kyphosis', 'Urethral Stricture-followed-Urinary Bladder Diseases', 'Urethral Stricture-followed-Urinary Fistula', 'Urethral Stricture-followed-Hematuria', 'Urethral Stricture-followed-Urinary Incontinence', 'Myocardial Infarction-followed-Acute Kidney Injury', 'Drug-Related Side Effects and Adverse Reactions-used-Wounds and Injuries', 'Alzheimer Disease-begin-Memory Disorders', 'Alzheimer Disease-ende-Dementia', 'Atrophy-begin-Memory Disorders', 'Atrophy-ende-Dementia', 'Pain Insensitivity, Congenital-used-Pain', 'HIV Infections-lead-Acquired Immunodeficiency Syndrome', 'Death-induce-Immunologic Deficiency Syndromes', 'Death-induce-Acquired Immunodeficiency Syndrome', 'HIV Infections-contribute-Immunologic Deficiency Syndromes', 'HIV Infections-reduce-Acquired Immunodeficiency Syndrome', 'Pneumonia-considered-Respiration Disorders', 'Hypertension-compare-Metabolic Syndrome', 'Corneal Edema-lead-Blindness', 'Melanoma-cause-Breast Neoplasms', 'Breast Neoplasms-bear-Neoplasms', 'Infections-control-Arbovirus Infections', 'Syncope, Vasovagal-experience-Drug Hypersensitivity', 'Syncope, Vasovagal-given-Drug Hypersensitivity', 'Critical Illness-reflect-Neurologic Manifestations', 'Diabetes Mellitus-adjusted-Hypertension', 'Diabetes Mellitus-adjusted-Cardiovascular Diseases', 'Death-define-Pulmonary Disease, Chronic Obstructive', 'Hip Fractures-undergo-Pulmonary Disease, Chronic Obstructive', 'Hip Fractures-improve-Pulmonary Disease, Chronic Obstructive', 'Dementia-calculated-Hip Fractures', 'Hip Fractures-suffer-Dementia', 'Dementia-constitute-Hip Fractures', 'Mucositis-include-Pneumococcal Infections', 'Death-share-Coma', 'Hypotension-tolerate-Death', 'Scleroderma, Localized-considered-Osteoarthritis', 'Pneumonia, Aspiration-play-Lung Injury', 'Pneumonia-play-Lung Injury', 'Neoplasms-develop-Xeroderma Pigmentosum', 'Death-predicted-Diabetes Mellitus, Type 2', 'Wounds and Injuries-considered-Pain', 'Temporomandibular Joint Disorders-characterized-Pain', 'Inflammation-considered-Pain', 'Temporomandibular Joint Disorders-include-Myofascial Pain Syndromes', 'Tics-considered-Pain', 'Infections-considered-Pain', 'Temporomandibular Joint Disorders-include-Fatigue Syndrome, Chronic', 'Neoplasms-considered-Pain', 'Inflammation-implicated-Pulmonary Disease, Chronic Obstructive', 'Alzheimer Disease-include-Vision Disorders', 'HIV Infections-receive-Lymphoma', 'Fever-treat-Lymphoma, AIDS-Related', 'Fever-evaluate-Communicable Diseases', 'Fever-associated-Communicable Diseases', 'Communicable Diseases-associated-Fever', 'Neutropenia-treat-Lymphoma, AIDS-Related', 'Neutropenia-evaluate-Communicable Diseases', 'Neutropenia-associated-Communicable Diseases', 'Communicable Diseases-associated-Neutropenia', 'Lymphoma, AIDS-Related-associated-Communicable Diseases', 'Communicable Diseases-associated-Lymphoma, AIDS-Related', 'Fever-defined-Neutropenia', 'Peri-Implantitis-associated-Mitral Valve Insufficiency', 'Mitral Valve Insufficiency-associated-Peri-Implantitis', 'Peripheral Arterial Disease-result-Pain', 'Diabetic Neuropathies-result-Pain', 'Bone Diseases, Metabolic-result-Pain', 'Hypertension-result-Pain', 'Diabetes Mellitus-result-Pain', 'Pain-adapted-Kidney Failure, Chronic', 'Neurodegenerative Diseases-lead-Mitochondrial Diseases', 'Bone Neoplasms-target-Osteoporosis', 'Metabolic Syndrome-associated-Dementia, Vascular', 'Dementia, Vascular-associated-Metabolic Syndrome', 'Metabolic Syndrome-link-Alzheimer Disease', 'Metabolic Syndrome-show-Obesity', 'Urinary Bladder Neoplasms-assess-Neoplasms', 'Hematuria-indicate-Urinary Bladder Neoplasms', 'Parkinson Disease-suggest-Alzheimer Disease', 'Neurodegenerative Diseases-rescue-Disease', 'Disease-prevent-Death', 'Fever-use-Pharyngeal Diseases', 'Fever-present-Pharyngeal Diseases', 'Fever-use-Cough', 'Fever-present-Cough', 'Renal Insufficiency-present-Pulmonary Edema', 'Renal Insufficiency-present-Cardiomyopathies', 'Renal Insufficiency-present-Hypocalcemia', 'Renal Insufficiency-contribute-Hypocalcemia', 'Pulmonary Edema-present-Hypocalcemia', 'Cardiomyopathies-present-Hypocalcemia', 'Stroke-show-Cerebral Infarction', 'Glucose Metabolism Disorders-measured-Alzheimer Disease', 'Glucose Metabolism Disorders-select-Alzheimer Disease', 'Alzheimer Disease-studied-Glucose Metabolism Disorders', 'Respiratory Insufficiency-cause-Death', 'Myasthenia Gravis-suspected-Deglutition Disorders', 'Myasthenia Gravis-suspected-Weight Loss', 'Atrophy-signify-Alzheimer Disease', 'Atrophy-examined-Alzheimer Disease', 'Atrophy-signify-Neurodegenerative Diseases', 'Infections-resemble-Cold Injury', 'Hematologic Diseases-classified-Immunologic Deficiency Syndromes', 'Hematologic Diseases-mediate-Immunologic Deficiency Syndromes', 'Immunologic Deficiency Syndromes-classified-Hematologic Diseases', 'Cardiovascular Diseases-ascertained-Death', 'Stroke-required-Thrombosis', 'Atrial Fibrillation-required-Thrombosis', 'Cholangiocarcinoma-induce-Communicable Diseases', 'HIV Infections-contribute-Cerebrovascular Disorders', 'Osteoporosis-address-Hip Fractures', 'Inflammation-cause-Drug-Related Side Effects and Adverse Reactions', 'Atherosclerosis-cause-Drug-Related Side Effects and Adverse Reactions', 'Neurotoxicity Syndromes-lead-Nerve Degeneration', 'Cerebral Hemorrhage-develop-Alzheimer Disease', 'Alzheimer Disease-range-Nerve Degeneration', 'Dementia-range-Nerve Degeneration', 'Alzheimer Disease-start-Dementia', 'Nephrosis, Lipoid-affected-Kidney Diseases', 'Glomerulonephritis-affected-Kidney Diseases', 'Eyelid Diseases-develop-Hyperalgesia', 'Long QT Syndrome-result-Torsades de Pointes', 'Long QT Syndrome-result-Arrhythmias, Cardiac', 'Venous Thromboembolism-omit-Obesity', 'Gastritis-reveal-Atrial Fibrillation', 'Lung Diseases-lack-Death', 'Postoperative Hemorrhage-associated-Death', 'Death-associated-Postoperative Hemorrhage', 'Inflammation-associated-Renal Insufficiency', 'Renal Insufficiency-associated-Inflammation', 'Diabetes Mellitus-based-Catastrophic Illness', 'Brain Neoplasms-isolate-Cleft Palate', 'Brain Neoplasms-isolate-Otitis', 'Brain Neoplasms-isolate-Pleural Effusion', 'Anisometropia-associated-Myopia', 'Myopia-associated-Anisometropia', 'Anisometropia-associated-Wounds and Injuries', 'Wounds and Injuries-associated-Anisometropia', 'Renal Insufficiency, Chronic-guided-Kidney Diseases', 'Disease-represent-Vision Disorders', 'Disease-represent-Blindness', 'Autoimmune Diseases-analyzed-Death', 'Myelodysplastic Syndromes-found-Anemia', 'Stomach Ulcer-include-Gastrointestinal Diseases', 'Ulcer-include-Gastrointestinal Diseases', 'Gastrointestinal Hemorrhage-include-Gastrointestinal Diseases', 'Joint Diseases-infected-Hepatitis C', 'Joint Diseases-infected-Hepatitis B', 'Liver Cirrhosis-associated-Hepatitis C', 'Hepatitis C-associated-Liver Cirrhosis', 'Nocturnal Myoclonus Syndrome-include-Sleep Wake Disorders', 'Inflammation-observed-Periodontitis', 'Neoplasms-sequenced-Leukemia, Myeloid, Acute', 'Neoplasms-induce-Atrial Fibrillation', 'Infections-given-Headache Disorders, Secondary', 'Stroke-incorporate-Diabetes Mellitus', 'Stroke-incorporate-Cardiovascular Diseases', 'Stroke-incorporate-Atrial Fibrillation', 'Stroke-incorporate-Cardiomyopathy, Hypertrophic', 'Mouth Breathing-identified-Periodontitis', 'Hemostatic Disorders-achieve-Hemorrhage', 'Heart Failure-contribute-Death', 'Ventricular Dysfunction, Left-contribute-Death', 'Diabetes Mellitus-identified-Stroke', 'Renal Insufficiency-identified-Stroke', 'Heart Failure-identified-Stroke', 'Thrombosis-diagnose-Aneurysm, False', 'Thrombosis-diagnose-Seroma', 'Thrombosis-diagnose-Edema', 'Hypotension-seem-Cerebral Infarction', 'Hypertension-based-Urination Disorders', 'Retinal Diseases-based-Urination Disorders', 'Acquired Immunodeficiency Syndrome-predict-Death', 'Ischemia-improve-Diabetes Mellitus', 'Polymyalgia Rheumatica-accompany-Arteritis', 'Sepsis-show-Microvascular Angina', 'Diabetes Mellitus-associate-Communicable Diseases', 'Communicable Diseases-associate-Diabetes Mellitus', 'Diabetes Mellitus-predispose-Infections', 'Hyperglycemia-associate-Diabetes Mellitus', 'Diabetes Mellitus-associate-Hyperglycemia', 'Headache-mistaken-Migraine Disorders', 'Neurologic Manifestations-mistaken-Migraine Disorders', 'Muscular Diseases-lead-Fatigue', 'Sepsis-explore-Death', 'Infections-associated-Pneumonia', 'Pneumonia-associated-Infections', 'Cerebral Small Vessel Diseases-observed-Infarction', 'Drug Hypersensitivity-appear-Asthma', 'Ischemia-play-Stroke', 'Neoplasm Invasiveness-included-Pneumococcal Infections', 'Thyroid Cancer, Papillary-investigate-Osteosarcoma', 'Death, Sudden, Cardiac-defined-Death', 'Death, Sudden, Cardiac-identify-Heart Failure', 'Death, Sudden, Cardiac-identify-Diabetes Mellitus', 'Death, Sudden, Cardiac-identify-Myocardial Infarction', 'Death, Sudden, Cardiac-identify-Carotid Artery Diseases', 'Death, Sudden, Cardiac-identify-Hypertension', 'Neurotoxicity Syndromes-use-Neuroblastoma', 'Infertility, Female-caused-Primary Ovarian Insufficiency', 'Death-attributed-Fractures, Bone', 'Aneurysm-come-Fistula', 'Aneurysm-continue-Death', 'Aneurysm-come-Infections', 'Aneurysm-come-Sepsis', 'Fistula-continue-Death', 'Fibrosis-regarded-Inflammation', 'Sleep Initiation and Maintenance Disorders-work-Memory Disorders', 'Brain Ischemia-induce-Nerve Degeneration', 'Brain Ischemia-induce-Heart Arrest', 'Weight Loss-reduce-Obesity', 'Death-live-Heart Failure', 'Cerebrovascular Disorders-examine-Brain Diseases', 'Brain Diseases-cause-Chronic Disease', 'Brain Diseases-cause-Death', 'Chronic Disease-cause-Death', 'Obesity-exhibit-Hypertension', 'Obesity-exhibit-Diabetes Mellitus', 'Wounds and Injuries-increase-Retinal Degeneration', 'Renal Insufficiency-contribute-Chronic Kidney Disease-Mineral and Bone Disorder', 'Chromosomal Instability-associate-Neoplasms', 'Neoplasms-associate-Chromosomal Instability', 'Headache Disorders, Primary-fulfil-Headache Disorders', 'Headache Disorders, Primary-considered-Neoplasms', 'Alzheimer Disease-propose-Dementia', 'Acquired Immunodeficiency Syndrome-identified-Death', 'Death-correct-Communicable Diseases', 'Nocturia-show-Sleep Wake Disorders', 'Vascular Calcification-compare-Infarction, Middle Cerebral Artery', 'Stroke-classified-Leukoencephalopathies', 'Infections-account-Chronic Disease', 'Periodontal Diseases-followed-Tooth Loss', 'Fractures, Bone-enable-Wounds and Injuries', 'Airway Obstruction-increase-Death', 'Constriction, Pathologic-increase-Death', 'Calcinosis-associate-Diabetes Mellitus', 'Diabetes Mellitus-associate-Calcinosis', 'Calcinosis-associate-Hypercholesterolemia', 'Hypercholesterolemia-associate-Calcinosis', 'Calcinosis-associate-Hypertension', 'Hypertension-associate-Calcinosis', 'Calcinosis-associate-Aortic Valve Insufficiency', 'Aortic Valve Insufficiency-associate-Calcinosis', 'Pruritus-followed-Neoplasms', 'Wounds and Injuries-characterize-Death', 'Death-diagnosed-Chronic Disease', 'Graves Disease-account-Thyrotoxicosis', 'Adenoma-account-Thyrotoxicosis', 'Thyroid Diseases-account-Thyrotoxicosis', 'Cardiac Output, Low-increase-Cardiovascular Diseases', 'Pulmonary Embolism-advance-Death', 'Cardiac Output, Low-increase-Hypertension', 'Cardiac Output, Low-increase-Dementia', 'Cardiac Output, Low-increase-Nervous System Diseases', 'Cardiac Output, Low-increase-Arthritis', 'Cardiac Output, Low-increase-Chronic Pain', 'Vascular Calcification-survey-Fractures, Bone', 'Atrial Fibrillation-induced-Arrhythmias, Cardiac', 'Atrial Fibrillation-reflect-Cardiomyopathies', 'Arrhythmias, Cardiac-reflect-Cardiomyopathies', 'Atrial Fibrillation-include-Ventricular Fibrillation', 'Heart Failure-include-Ventricular Fibrillation', 'Progeria-develop-Cerebral Infarction', 'Musculoskeletal Pain-experience-Neuralgia', 'Diabetes Mellitus-associated-Neuralgia', 'Neuralgia-associated-Diabetes Mellitus', 'Chronic Disease-associated-Radiculopathy', 'Radiculopathy-associated-Chronic Disease', 'Chronic Disease-associated-Diabetic Neuropathies', 'Diabetic Neuropathies-associated-Chronic Disease', 'Radiculopathy-associated-Neuralgia', 'Neuralgia-associated-Radiculopathy', 'Neuralgia-described-Brachial Plexus Neuritis', 'Neuralgia-described-Polyneuropathies', 'Diabetic Neuropathies-associated-Neuralgia', 'Neuralgia-associated-Diabetic Neuropathies', 'Neuralgia-described-Mononeuropathies', 'Angina Pectoris-achieved-Diabetes Mellitus', 'Hypercholesterolemia-use-Brain Infarction', 'Diabetes Mellitus-achieved-Angina Pectoris', 'Memory Disorders-predict-Alzheimer Disease', 'Neoplasms-conferred-Necrosis', 'Pain-accelerate-Fractures, Bone', 'Wounds and Injuries-receive-Hematoma, Subdural, Chronic', 'Prostatic Neoplasms-induce-Gynecomastia', 'Prostatic Neoplasms-associated-Breast Neoplasms', 'Breast Neoplasms-associated-Prostatic Neoplasms', 'Gynecomastia-associated-Breast Neoplasms', 'Breast Neoplasms-associated-Gynecomastia', 'Sarcopenia-characterized-Neuromuscular Diseases', 'Spinal Cord Injuries-include-Death', 'Cachexia-distinguish-Neoplasms', 'Diabetes Mellitus-accompanied-Osteoporosis', 'Albuminuria-related-Adrenal Insufficiency', 'Diabetes Mellitus-recognized-Diabetes Mellitus, Type 2', 'Osteoporosis-recognized-Diabetes Mellitus, Type 2', 'Neurotoxicity Syndromes-recommended-Seizures', 'Thromboembolism-pose-Hemorrhage', 'Stroke-pose-Hemorrhage', 'Factor X Deficiency-pose-Hemorrhage', 'Multiple Sclerosis-study-Neurodegenerative Diseases', 'Mitochondrial Diseases-increase-Aneurysm', 'Neoplasms-rise-Obesity', 'Pain-suffer-Neoplasms', 'Pain-suffer-Death', 'Hyponatremia-fall-Fractures, Bone', 'Fractures, Bone-contribute-Osteoporosis', 'Hyponatremia-prevent-Fractures, Bone', 'Heart Arrest-reduce-Rupture', 'Peripheral Arterial Disease-reported-Death', 'Bundle-Branch Block-cause-Ventricular Fibrillation', 'Bundle-Branch Block-influence-Ischemia', 'Ventricular Fibrillation-influence-Ischemia', 'Kidney Diseases-managed-Inflammation', 'Inflammation-complicated-Renal Insufficiency, Chronic', 'Diabetes Mellitus-complicated-Renal Insufficiency, Chronic', 'Metabolic Syndrome-attenuated-Inflammation', 'Metabolic Syndrome-explain-Obesity, Abdominal', 'Alzheimer Disease-related-Infarction', 'Death-undergo-Alzheimer Disease', 'Hip Fractures-associated-Bone Diseases', 'Bone Diseases-associated-Hip Fractures', 'Bone Diseases, Metabolic-progress-Osteoporosis', 'Tachycardia-exacerbate-Coronary Artery Disease', 'Atrophy-superimposed-Nerve Degeneration', 'Neuroleptic Malignant Syndrome-occur-Parkinson Disease', 'Atherosclerosis-delay-Dementia', 'Dementia, Vascular-develop-Alzheimer Disease', 'Alzheimer Disease-remove-Aneurysm', 'Neoplasms-protect-Mitochondrial Diseases', 'Atherosclerosis-present-Infarction', 'HIV Infections-include-Immunologic Deficiency Syndromes', 'Diabetes Mellitus-affect-Spinal Cord Injuries', 'Diabetes Mellitus-complicated-Pulmonary Edema', 'Diabetes Mellitus-complicated-Hypertension', 'Hemorrhage-referred-Non-ST Elevated Myocardial Infarction', 'Hemorrhage-complicated-Pulmonary Edema', 'Hemorrhage-complicated-Hypertension', 'Non-ST Elevated Myocardial Infarction-complicated-Pulmonary Edema', 'Non-ST Elevated Myocardial Infarction-complicated-Hypertension', 'Pulmonary Edema-complicated-Hypertension', 'Stroke-used-Atherosclerosis', 'Stroke-used-Arterial Occlusive Diseases', 'Stroke-used-Sepsis', 'Cerebral Infarction-classified-Sepsis', 'Cardiovascular Diseases-protect-Neoplasms', 'Venous Thromboembolism-increase-Obesity', 'Inflammation-play-Mitochondrial Diseases', 'Peripheral Vascular Diseases-associated-Cerebral Infarction', 'Cerebral Infarction-associated-Peripheral Vascular Diseases', 'Muscular Diseases-correlated-Death', 'Infections-include-Atrial Fibrillation', 'Thyroid Diseases-include-Atrial Fibrillation', 'Death-suspected-Infections', 'Carcinoma, Hepatocellular-inhibit-Neoplasms', 'Diarrhea-associated-Constipation', 'Constipation-associated-Diarrhea', 'HIV Infections-complicated-Lung Diseases', 'HIV Infections-control-Pregnancy Complications, Infectious', 'HIV Infections-control-Meningitis, Bacterial', 'HIV Infections-control-Tuberculosis', 'Pulmonary Disease, Chronic Obstructive-become-HIV Infections', 'Lung Neoplasms-become-HIV Infections', 'Asthma-become-HIV Infections', 'Hypertension, Pulmonary-become-HIV Infections', 'Hypotension-include-Kidney Failure, Chronic', 'Malnutrition-include-Kidney Failure, Chronic', 'Infections-include-Kidney Failure, Chronic', 'HIV Infections-related-Opportunistic Infections', 'Acquired Immunodeficiency Syndrome-related-Opportunistic Infections', 'Diabetes Mellitus-comprise-Glucose Intolerance', 'Nocturia-include-Prostatic Hyperplasia', 'Prostatic Hyperplasia-do-Sleep Wake Disorders', 'Nocturia-do-Sleep Wake Disorders', 'Prediabetic State-comprise-Glucose Intolerance', 'Anemia-understand-Inflammation', 'Anemia-understand-Critical Illness', 'Inflammation-understand-Critical Illness', 'Inflammation-enhance-Niemann-Pick Disease, Type A', 'Breast Neoplasms-link-Carcinogenesis', 'Intracranial Aneurysm-inhibit-Aneurysm', 'Neurodegenerative Diseases-define-Parkinson Disease', 'Acquired Immunodeficiency Syndrome-identify-Lymphoma, AIDS-Related', 'Aniseikonia-measured-Vision Disorders', 'Aniseikonia-range-Vision Disorders', 'Hypogonadism-linked-Erectile Dysfunction', 'Hypogonadism-linked-Metabolic Syndrome', 'Hypogonadism-linked-Diabetes Mellitus', 'Hypogonadism-linked-Obesity', 'Hypogonadism-linked-Osteoporosis', 'Death-show-Iatrogenic Disease', 'Mitochondrial Diseases-underpin-Neurodegenerative Diseases', 'Mitochondrial Diseases-underpin-Cardiovascular Diseases', 'Hypoglycemia-implicate-Death', 'Mitochondrial Diseases-underpin-Neoplasms', 'Iatrogenic Disease-associated-Death', 'Death-associated-Iatrogenic Disease', 'Iatrogenic Disease-associated-Hypoglycemia', 'Hypoglycemia-associated-Iatrogenic Disease', 'Candidemia-initiate-Death', 'Dementia-increase-Delirium', 'Psychoses, Substance-Induced-increase-Delirium', 'Infections-protect-Diabetes Mellitus', 'Hallucinations-followed-Vision Disorders', 'Hallucinations-followed-Agnosia', 'Seminoma-encountered-Neoplasms', 'Kidney Diseases-followed-Diabetic Nephropathies', 'Kidney Diseases-followed-Nephrotic Syndrome', 'Kidney Diseases-followed-Glomerulosclerosis, Focal Segmental', 'Atrophy-include-Deglutition Disorders', 'Stroke-include-Deglutition Disorders', 'Neurodegenerative Diseases-include-Deglutition Disorders', 'Muscular Diseases-include-Deglutition Disorders', 'Neoplasms-include-Deglutition Disorders', 'Deglutition Disorders-occur-Death', 'Death-worsen-Chronic Disease', 'Hypercholesterolemia-associated-Leukoencephalopathies', 'Leukoencephalopathies-associated-Hypercholesterolemia', 'Neurodegenerative Diseases-defined-Alzheimer Disease', 'Thoracic Diseases-use-Musculoskeletal Diseases', 'Hernia, Hiatal-use-Musculoskeletal Diseases', 'Neurodegenerative Diseases-recognized-Inflammation', 'Inflammation-recognized-Communicable Diseases', 'Inflammation-based-Communicable Diseases', 'Inflammation-based-Obesity', 'Death-use-Aortic Aneurysm', 'Aneurysm, Ruptured-considered-Death', 'Death-identified-Aneurysm, Ruptured', 'Carcinoma, Hepatocellular-play-Neoplasms', 'Psoriasis-generalize-Erythema Nodosum', 'Psoriasis-appear-Erythema Nodosum', 'Kidney Diseases-predict-Anemia', 'Pediatric Obesity-reported-Hypoglycemia', 'Kidney Failure, Chronic-develop-Hyperkalemia', 'Growth Disorders-contribute-Sarcopenia', 'Neurodegenerative Diseases-increase-Death', 'Neoplasms-associated-Liver Failure', 'Liver Failure-associated-Neoplasms', 'Neoplasms-underlie-Liver Failure', 'Cerebrovascular Disorders-increase-Ischemia', 'Cerebrovascular Disorders-increase-Dementia', 'Ischemia-increase-Dementia', 'Acquired Immunodeficiency Syndrome-living-Neoplasms', 'Delirium-treat-Critical Illness', 'Delirium-prevent-Critical Illness', 'Bone Neoplasms-integrate-Amyloidosis', 'Amyloidosis-cause-Carpal Tunnel Syndrome', 'Hypoglycemia-observed-Hypotension', 'Diabetes Mellitus-make-Renal Insufficiency, Chronic', 'Asbestosis-increase-Mesothelioma', 'Heart Failure-characterized-Sleep Initiation and Maintenance Disorders', 'Heart Failure-characterized-Heart Diseases', 'Renal Insufficiency, Chronic-reduce-Death', 'Hearing Loss-affected-Parkinson Disease', 'Parkinson Disease-show-Hearing Loss', 'Seizures-prevent-Spinal Cord Injuries', 'Coronary Artery Disease-estimated-Death', 'Neurologic Manifestations-play-Cerebral Small Vessel Diseases', 'Glucose Metabolism Disorders-associated-Heart Diseases', 'Heart Diseases-associated-Glucose Metabolism Disorders', 'Renal Insufficiency, Chronic-decrease-Obesity', 'Hypertension-decrease-Obesity', 'Diabetes Mellitus-decrease-Obesity', 'Arthritis-associated-Stroke', 'Stroke-associated-Arthritis', 'Arthritis-associated-Hypertension', 'Hypertension-associated-Arthritis', 'Arthritis-associated-Bronchitis', 'Bronchitis-associated-Arthritis', 'Arthritis-associated-Gastrointestinal Diseases', 'Gastrointestinal Diseases-associated-Arthritis', 'Neurodegenerative Diseases-induced-Hyperlipidemias', 'Dementia-include-Hypertension', 'Fracture Dislocation-fix-Fractures, Bone', 'Hypertension-include-Alzheimer Disease', 'Atrial Fibrillation-lead-Stroke', 'Atrial Fibrillation-needed-Stroke', 'Seizures-contribute-Sarcopenia', 'Pain-function-Dystonia', 'Pain-relieve-Arthritis, Psoriatic', 'Death-develop-Cholecystitis, Acute', 'Dyskinesia, Drug-Induced-include-Basal Ganglia Diseases', 'Renal Insufficiency, Chronic-prevent-Dementia', 'Obesity-tend-Death', 'Pain-occur-Stroke', 'Pain-caused-Leukoencephalopathies', 'Pain-address-Dementia', 'Neuralgia-known-Stroke', 'Neuralgia-occur-Stroke', 'Neuralgia-address-Dementia', 'Neuralgia-caused-Leukoencephalopathies', 'Stroke-caused-Leukoencephalopathies', 'Pain-start-Dementia', 'Dementia-affect-Acute Coronary Syndrome', 'Neoplasms-move-Death', 'Osteoarthritis-focused-Weight Loss', 'Osteoarthritis-use-Weight Loss', 'Neoplasms-register-Colorectal Neoplasms', 'Shy-Drager Syndrome-cause-Heart Failure', 'Shy-Drager Syndrome-thrive-Atherosclerosis', 'Shy-Drager Syndrome-thrive-Death', 'Heart Failure-thrive-Atherosclerosis', 'Heart Failure-thrive-Death', 'Progeria-improve-Aneurysm', 'Atherosclerosis-accelerate-Death', 'Muscle Rigidity-hear-Hearing Loss, Central', 'Pulmonary Disease, Chronic Obstructive-hospitalized-Dyspnea', 'Pulmonary Disease, Chronic Obstructive-manage-Respiratory Insufficiency', 'Pulmonary Disease, Chronic Obstructive-characterized-Death', 'Dementia-admitted-Stroke', 'Dementia-admitted-Fractures, Bone', 'Diabetic Foot-result-Death', 'Liver Diseases-stratified-Carcinoma, Hepatocellular', 'Liver Diseases-associated-Hepatitis C', 'Hepatitis C-associated-Liver Diseases', 'Death-assess-Hereditary Breast and Ovarian Cancer Syndrome', 'Alzheimer Disease-suggest-Death', 'Crohn Disease-highlight-Death', 'Death-include-Bacteremia', 'Cardiac Output, Low-live-Fatigue', 'Vision Disorders-live-Fatigue', 'Coma-correlate-Death', 'Wounds and Injuries-correlate-Death', 'Diabetes Mellitus-influence-Death', 'Infections-included-Bronchitis', 'Death-occur-Aortic Valve Stenosis', 'HIV Infections-result-Stroke', 'Stroke-result-Opportunistic Infections', 'Stroke-result-Basal Ganglia Cerebrovascular Disease', 'Stroke-result-Blood Coagulation Disorders', 'HIV Infections-describe-Basal Ganglia Cerebrovascular Disease', 'HIV Infections-caused-Constriction, Pathologic', 'HIV Infections-caused-Aneurysm', 'HIV Infections-caused-Vasculitis', 'HIV Infections-caused-Atherosclerosis', 'Basal Ganglia Cerebrovascular Disease-describe-Constriction, Pathologic', 'Basal Ganglia Cerebrovascular Disease-caused-Aneurysm', 'Basal Ganglia Cerebrovascular Disease-describe-Vasculitis', 'Basal Ganglia Cerebrovascular Disease-caused-Atherosclerosis', 'Basal Ganglia Cerebrovascular Disease-caused-HIV Infections', 'Constriction, Pathologic-caused-HIV Infections', 'Aneurysm-caused-HIV Infections', 'Vasculitis-caused-HIV Infections', 'Atherosclerosis-caused-HIV Infections', 'Metabolic Diseases-use-Seizures', 'Neoplasms-constitute-Lung Neoplasms', 'Fractures, Bone-need-Osteoporosis', 'Fractures, Bone-identify-Osteoporotic Fractures', 'Epstein-Barr Virus Infections-play-Neoplasms', 'Lymphoma, Non-Hodgkin-represent-Neoplasms', 'Neoplasms-represent-Lymphoma, B-Cell', 'Arthritis, Psoriatic-develop-Neoplasms', 'Psoriasis-confer-Neoplasms', 'Psoriasis-associated-Neoplasms', 'Neoplasms-associated-Psoriasis', 'Hyperparathyroidism-associated-Hypercalcemia', 'Hypercalcemia-associated-Hyperparathyroidism', 'Hypercalcemia-develop-Kidney Diseases', 'Hyperparathyroidism-develop-Kidney Diseases', 'Neoplasms-change-Death', 'Stroke-followed-Neurologic Manifestations', 'Neurodegenerative Diseases-protect-Death', 'Cough-shown-Respiratory Tract Infections', 'Cough-experience-Death', 'Heart Failure-promote-Ischemia', 'Heart Failure-promote-Hypotension', 'Oculocerebrorenal Syndrome-result-Osteoporosis', 'Death-compare-Multiple Trauma', 'HIV Infections-make-Muscular Dystrophy, Duchenne', 'Neurodegenerative Diseases-prevent-Death', 'Ependymoma-originate-Memory Disorders', 'Ependymoma-manifest-Memory Disorders', 'Edema-recover-Gait Disorders, Neurologic', 'Hydrocephalus-recover-Gait Disorders, Neurologic', 'Communicable Diseases-cause-Bacterial Infections', 'Death-cause-Bacterial Infections', 'Bacterial Infections-cause-Death', 'Coronary Artery Disease-associate-Heart Failure', 'Heart Failure-associate-Coronary Artery Disease', 'Vascular Calcification-associated-Heart Failure', 'Heart Failure-associated-Vascular Calcification', 'Vascular Calcification-associate-Heart Failure', 'Heart Failure-associate-Vascular Calcification', 'Heart Failure-include-Vascular Calcification', 'Heart Failure-incorporate-Vascular Calcification', 'Hematoma-develop-Postoperative Hemorrhage', 'Hematoma-resolve-Neurologic Manifestations', 'Death-develop-Postoperative Hemorrhage', 'Postoperative Hemorrhage-resolve-Neurologic Manifestations', 'Death-attributed-Cardiovascular Diseases', 'Infections-develop-Uterine Retroversion', 'Hemorrhage-develop-Uterine Retroversion', 'Leg Ulcer-occur-Aneurysm', 'Leg Ulcer-occur-Venous Insufficiency', 'Ulcer-present-Epidermolysis Bullosa Dystrophica', 'Genetic Diseases, Inborn-considered-Leg Ulcer', 'Heart Diseases-determine-Diabetes Mellitus', 'Pain-include-Fractures, Bone', 'Cardiac Output, Low-include-Fractures, Bone', 'Hemophilia A-continue-Joint Diseases', 'Osteoarthritis-use-Sleep Initiation and Maintenance Disorders', 'Inflammation-modulate-Carcinogenesis', 'Hypertension-compare-Inflammation', 'Arthritis, Rheumatoid-compare-Hypertension', 'Osteoarthritis-compare-Hypertension', 'Arthritis, Rheumatoid-compare-Inflammation', 'Arthritis, Rheumatoid-exposed-Inflammation', 'Osteoarthritis-compare-Inflammation', 'Osteoarthritis-exposed-Inflammation', 'Hearing Loss-based-Hearing Disorders', 'Hearing Loss-address-Hearing Disorders', 'Werner Syndrome-associated-Inflammation', 'Inflammation-associated-Werner Syndrome', 'Osteoporotic Fractures-form-Fractures, Bone', 'Fractures, Bone-increase-Fever', 'Retinal Degeneration-followed-Vision Disorders', 'Corneal Diseases-followed-Vision Disorders', 'Vision Disorders-followed-Optic Nerve Diseases', 'Vision Disorders-followed-Diabetes Mellitus', 'Ossification, Heterotopic-include-Venous Thrombosis', 'Ossification, Heterotopic-include-Pulmonary Embolism', 'Ossification, Heterotopic-include-Infections', 'Sleep Wake Disorders-over-ride-Urinary Bladder Diseases', 'Nocturia-over-ride-Urinary Bladder Diseases', 'Prostatic Hyperplasia-associated-Nocturia', 'Nocturia-associated-Prostatic Hyperplasia', 'Prostatic Hyperplasia-observed-Nocturia', 'Urinary Bladder Diseases-over-ride-Sleep Wake Disorders', 'Death-treated-Breast Neoplasms', 'Stroke-reflect-Deglutition Disorders', 'Dementia-reflect-Deglutition Disorders', 'Acquired Immunodeficiency Syndrome-reduce-Inflammation', 'Acquired Immunodeficiency Syndrome-reduce-HIV Infections', 'Death-shown-Acute Disease', 'Hyperlipidemias-increase-Venous Thrombosis', 'Metabolic Syndrome-increase-Venous Thrombosis', 'Atrophy-noted-Alzheimer Disease', 'Atrophy-recorded-Alzheimer Disease', 'Stroke-lack-Memory Disorders', 'Alzheimer Disease-show-Dementia', 'Death-occur-Anemia', 'Death-improve-Tuberculosis', 'Death-get-Bacterial Infections', 'Cleft Lip-delivered-Fistula', 'Peripheral Arterial Disease-associated-Hyperlipidemias', 'Hyperlipidemias-associated-Peripheral Arterial Disease', 'Fractures, Bone-distinguish-Oculocerebrorenal Syndrome', 'Neoplasms-recognized-Carcinogenesis', 'Dementia-preoccupied-Alzheimer Disease', 'Hypoalbuminemia-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-Hypoalbuminemia', 'Renal Artery Obstruction-noted-Ischemia', 'Death-found-Bone Marrow Diseases', 'Death-follow-Bone Marrow Diseases', 'Sepsis-follow-Bone Marrow Diseases', 'Cardiac Output, Low-contribute-Diabetes Mellitus', 'Hematoma, Subdural, Chronic-caused-Craniocerebral Trauma', 'Neurologic Manifestations-display-Confusion', 'Neurologic Manifestations-display-Coma', 'Learning Disabilities-participate-Infections', 'Death-associated-Hematemesis', 'Hematemesis-associated-Death', 'Embolism-require-Intraoperative Complications', 'Phimosis-lead-Arthritis, Infectious', 'Infections-lead-Arthritis, Infectious', 'Balanitis-lead-Arthritis, Infectious', 'Sarcopenia-affected-Anorexia', 'Ulcer-treat-Death', 'HIV Infections-contribute-Immune System Diseases', 'Immunologic Deficiency Syndromes-ameliorate-Anophthalmos', 'Atrial Fibrillation-contribute-Death', 'Neoplasms-show-Brain Diseases', 'Latent Tuberculosis-exclude-Tuberculosis', 'Periodontitis-use-Fractures, Bone', 'Cardiovascular Diseases-affected-Pulmonary Disease, Chronic Obstructive', 'Asthma-affected-Pulmonary Disease, Chronic Obstructive', 'Diabetes Mellitus-affected-Pulmonary Disease, Chronic Obstructive', 'Obesity-affected-Pulmonary Disease, Chronic Obstructive', 'Metabolic Syndrome-affected-Pulmonary Disease, Chronic Obstructive', 'Osteoporosis-affected-Pulmonary Disease, Chronic Obstructive', 'Chemical and Drug Induced Liver Injury-cause-Liver Diseases', 'Hepatitis D, Chronic-lead-Fibrosis', 'Hepatitis B, Chronic-lead-Fibrosis', 'Metabolic Diseases-known-Neurologic Manifestations', 'Metabolic Diseases-involved-Neurologic Manifestations', 'Cold Injury-increase-Coronary Artery Disease', 'Fibrosis-underlie-Coronary Artery Disease', 'Lung Diseases-associated-Ventricular Dysfunction', 'Ventricular Dysfunction-associated-Lung Diseases', 'Sleep Wake Disorders-reported-Hypercapnia', 'Nijmegen Breakage Syndrome-evaluate-Bone Neoplasms', 'Bacteremia-increase-Death', 'Malnutrition-caused-Infections', 'Meningitis, Bacterial-point-Neurodegenerative Diseases', 'Central Nervous System Infections-produce-Multiple Trauma', 'Arbovirus Infections-point-Neurodegenerative Diseases', 'Central Nervous System Infections-produce-Infections', 'Multiple Trauma-produce-Infections', 'Arbovirus Infections-point-Alzheimer Disease', 'Arbovirus Infections-point-Parkinson Disease', 'Gallstones-admitted-Abdominal Pain', 'Gallstones-admitted-Vomiting', 'Gallstones-admitted-Constipation', 'Cerebral Infarction-ascertained-Death', 'Death-display-Dementia', 'Progeria-show-Growth Disorders', 'Progeria-show-Fractures, Bone', 'Neoplasms-adjusted-Death', 'Brain Injuries, Traumatic-represent-Death', 'Diabetes Mellitus, Type 2-approved-Stroke', 'Diabetes Mellitus, Type 2-approved-Parkinson Disease', 'Colorectal Neoplasms-exclude-Skin Neoplasms', 'Melanoma-diagnose-Neoplasms', 'Alzheimer Disease-detect-Hypotension, Orthostatic', 'Inflammation-contain-Atherosclerosis', 'Inflammation-contain-Diabetes Mellitus', 'Inflammation-contain-Glaucoma', 'Obesity-linked-Atrophy', 'Obesity-develop-Dementia', 'Neoplasms-become-Carcinoma, Hepatocellular', 'Death-become-Carcinoma, Hepatocellular', 'Nerve Degeneration-seem-Brain Diseases', 'Dementia-seem-Brain Diseases', 'Alzheimer Disease-involve-Inflammation', 'Leukoencephalopathies-indicate-Cerebral Small Vessel Diseases', 'Burkitt Lymphoma-preclude-Drug-Related Side Effects and Adverse Reactions', 'Burkitt Lymphoma-use-Neoplasms', 'Lymphoma, B-Cell-use-Neoplasms', 'Delirium-show-Psychomotor Agitation', 'Delirium-develop-Hyperkinesis', 'Abortion, Threatened-highlight-Status Epilepticus', 'Hyperkinesis-limit-Drug-Related Side Effects and Adverse Reactions', 'Aging, Premature-considered-Primary Ovarian Insufficiency', 'Primary Ovarian Insufficiency-predispose-Ovarian Diseases', 'Ovarian Hyperstimulation Syndrome-undergo-Primary Ovarian Insufficiency', 'Death-raised-Hyponatremia', 'Cardiac Output, Low-exhibit-Fractures, Bone', 'Death-exhibit-Fractures, Bone', 'Anemia-correlated-Bacterial Infections', 'Cardiomyopathy, Hypertrophic-transformed-Genetic Diseases, Inborn', 'Cardiomyopathy, Hypertrophic-lead-Heart Failure', 'Cardiomyopathy, Hypertrophic-lead-Stroke', 'Death, Sudden-lead-Heart Failure', 'Death, Sudden-lead-Stroke', 'Death, Sudden-prevent-Airway Obstruction', 'Death, Sudden-prevent-Stroke', 'Airway Obstruction-prevent-Stroke', 'Heart Failure-control-Atrial Fibrillation', 'Heart Failure-prevent-Stroke', 'Radial Neuropathy-measured-Inflammation', 'Hypertension-prevent-Coronary Artery Disease', 'Death-identify-Maternal Death', 'Pain-result-Myalgia', 'Pain-burn-Myalgia', 'Pain-result-Hyperalgesia', 'Duodenal Ulcer-associated-Death', 'Death-associated-Duodenal Ulcer', 'Corneal Diseases-manage-Infections', 'Pain-include-Obesity', 'Movement Disorders-work-Joint Diseases', 'Breast Neoplasms-predispose-Neoplasms', 'Osteomyelitis-reported-Fractures, Bone', 'Cardiovascular Diseases-include-Fatigue', 'Pain-improve-Spinal Stenosis', 'Cerebrovascular Disorders-accompany-Dementia, Vascular', 'Psychoses, Substance-Induced-accompany-Dementia, Vascular', 'Psychoses, Substance-Induced-compare-Alzheimer Disease', 'Diabetes Mellitus-suffer-Hip Fractures', 'Chronic Disease-related-Inflammation', 'Diplopia-resolved-Vision Disorders', 'Hip Dislocation-associated-Oculocerebrorenal Syndrome', 'Oculocerebrorenal Syndrome-associated-Hip Dislocation', 'Stroke-related-Leukoencephalopathies', 'Neurotoxicity Syndromes-occur-Nerve Degeneration', 'Obesity-result-Breast Neoplasms', 'Deglutition Disorders-show-Pneumonia', 'Death-present-Brain Diseases', 'Mitral Valve Insufficiency-followed-Coronary Artery Disease', 'Coronary Artery Disease-followed-Aortic Valve Stenosis', 'HIV Infections-live-Diabetes Mellitus, Type 2', 'Hyperthyroidism-associated-Erectile Dysfunction', 'Erectile Dysfunction-associated-Hyperthyroidism', 'HIV Infections-develop-Death', 'HIV Infections-accelerate-Cytomegalovirus Infections', 'Pain-impact-Dementia', 'Alzheimer Disease-associated-Sleepiness', 'Sleepiness-associated-Alzheimer Disease', 'Death-occur-Cholecystitis, Acute', 'Sleepiness-contribute-Alzheimer Disease', 'Multiple Myeloma-play-Hereditary Breast and Ovarian Cancer Syndrome', 'Chronic Disease-treat-Taste Disorders', 'Osteoporosis-lack-Fractures, Bone', 'Fractures, Bone-related-Bone Neoplasms', 'Bone Neoplasms-result-Death', 'Plasmacytoma-progress-Multiple Myeloma', 'Hypertension-admitted-Muscle Weakness', 'Hypertension-admitted-Dyspnea', 'Hypertension-admitted-Fever', 'Stroke-decrease-Encephalitis', 'Stroke-reduce-Neurotoxicity Syndromes', 'Stroke-reduce-Brain Injuries, Traumatic', 'Neurotoxicity Syndromes-reduce-Brain Injuries, Traumatic', 'Stroke-reduce-Alzheimer Disease', 'Infections-include-Seizures', 'Infections-include-Enterocolitis', 'Gallstones-consider-Cholelithiasis', 'Fibrosis-last-Arbovirus Infections', 'Muscular Dystrophies, Limb-Girdle-characterized-Muscular Atrophy', 'Meningeal Neoplasms-remain-Neoplasms', 'Puberty, Delayed-characterised-Ataxia', 'Puberty, Delayed-progress-Paralysis', 'Puberty, Delayed-progress-Motor Neuron Disease', 'Neurodegenerative Diseases-characterised-Ataxia', 'Neurodegenerative Diseases-progress-Paralysis', 'Neurodegenerative Diseases-progress-Motor Neuron Disease', 'Ataxia-progress-Paralysis', 'Ataxia-progress-Motor Neuron Disease', 'Hip Fractures-follow-Dementia', 'Delirium-improve-Hip Fractures', 'Ventricular Fibrillation-remain-Pulmonary Disease, Chronic Obstructive', 'Inflammation-remain-Pulmonary Disease, Chronic Obstructive', 'Pain-cause-Hypogonadism', 'Cancer Pain-cause-Hypogonadism', 'HIV Infections-assess-Inflammation', 'HIV Infections-assess-Thrombophilia', 'Neuralgia-cause-Hypogonadism', 'Constipation-do-Sphincter of Oddi Dysfunction', 'Constipation-cause-Hypogonadism', 'Sphincter of Oddi Dysfunction-cause-Hypogonadism', 'Sphincter of Oddi Dysfunction-associated-Death, Sudden', 'Death, Sudden-associated-Sphincter of Oddi Dysfunction', 'Respiratory Insufficiency-cause-Hypogonadism', 'Hypothalamic Neoplasms-cause-Hypogonadism', 'Hypothalamic Neoplasms-associated-Death, Sudden', 'Death, Sudden-associated-Hypothalamic Neoplasms', 'Death, Sudden-associated-Renal Insufficiency', 'Renal Insufficiency-associated-Death, Sudden', 'Stroke-experience-Ischemia', 'Atrial Fibrillation-experience-Ischemia', 'Ischemia-experience-Stroke', 'Dementia-estimated-Alzheimer Disease', 'Renal Insufficiency, Chronic-analyzed-Death', 'Sarcopenia-affect-Frailty', 'Abnormalities, Drug-Induced-cause-Gastrointestinal Hemorrhage', 'Intestinal Neoplasms-cause-Gastrointestinal Hemorrhage', 'Crohn Disease-cause-Gastrointestinal Hemorrhage', 'Ulcer-cause-Gastrointestinal Hemorrhage', 'Cough-predispose-Gastroesophageal Reflux', 'Obesity-benefit-Weight Loss', 'Inflammation-predispose-Vascular Remodeling', 'Erectile Dysfunction-establish-Cardiovascular Diseases', 'Erectile Dysfunction-support-Cardiovascular Diseases', 'Erectile Dysfunction-support-Diabetes Mellitus', 'Erectile Dysfunction-review-Diabetes Mellitus', 'Erectile Dysfunction-represent-Cardiovascular Diseases', 'Musculoskeletal Pain-recognised-Fibromyalgia', 'Pain-recognised-Fibromyalgia', 'Jaundice-follow-Tuberculosis', 'Alcoholism-work-Pain', 'Alcoholism-work-Low Back Pain', 'Low Back Pain-include-Osteoarthritis', 'Atherosclerosis-followed-Aneurysm', 'Low Back Pain-include-Arthritis, Rheumatoid', 'Pain-include-Gout', 'Low Back Pain-include-Gout', 'Sarcopenia-used-Obesity', 'Sarcopenia-define-Obesity', 'Polycythemia Vera-aimed-Thrombosis', 'Thrombocythemia, Essential-aimed-Thrombosis', 'Polycythemia Vera-stratified-Thrombosis', 'Polycythemia Vera-impact-Death', 'Syncope-defined-Unconsciousness', 'Skin Ulcer-associated-Venous Insufficiency', 'Venous Insufficiency-associated-Skin Ulcer', 'Neoplasms-submitted-Lung Neoplasms', 'Asthma-confused-Heart Failure', 'Asthma-confused-Pulmonary Disease, Chronic Obstructive', 'Xerostomia-followed-Dysgeusia', 'Xerostomia-followed-Pain', 'Urinary Incontinence-found-Urinary Bladder, Overactive', 'Nocturnal Enuresis-found-Urinary Bladder, Overactive', 'Hypertension-share-Osteoporosis', 'Diabetes Mellitus-share-Osteoporosis', 'Hyperlipidemias-share-Osteoporosis', 'Acute Coronary Syndrome-given-Death', 'Muscle Spasticity-occur-Stroke', 'Muscle Spasticity-occur-Muscle Weakness', 'Stroke-occur-Muscle Weakness', 'Neoplasms-review-HIV Infections', 'Neoplasms-detect-Inflammation', 'Erectile Dysfunction-associated-Angina Pectoris', 'Angina Pectoris-associated-Erectile Dysfunction', 'Erectile Dysfunction-associated-Myocardial Infarction', 'Myocardial Infarction-associated-Erectile Dysfunction', 'Erectile Dysfunction-associated-Stroke', 'Stroke-associated-Erectile Dysfunction', 'Cardiovascular Diseases-list-Death', 'Sleep Apnea, Obstructive-associated-Erectile Dysfunction', 'Erectile Dysfunction-associated-Sleep Apnea, Obstructive', 'Cerebrovascular Disorders-score-Stroke', 'Stroke-contribute-Chemical and Drug Induced Liver Injury', 'Alzheimer Disease-came-Cardiovascular Diseases', 'Alzheimer Disease-came-Diabetes Mellitus', 'Alzheimer Disease-rank-Dementia', 'Alzheimer Disease-represent-Infections', 'Metabolic Diseases-observed-Alzheimer Disease', 'Teratocarcinoma-depleted-Alzheimer Disease', 'Lung Neoplasms-include-Emphysema', 'Cockayne Syndrome-characterized-Hearing Loss, Central', 'Inflammation-developed-Mitochondrial Diseases', 'Basal Ganglia Cerebrovascular Disease-related-Alzheimer Disease', 'Death-affected-Diabetes Mellitus', 'Lymphoma-found-Lupus Erythematosus, Systemic', 'Glucose Metabolism Disorders-evaluate-Dementia', 'Glucose Metabolism Disorders-associated-Headache Disorders, Secondary', 'Headache Disorders, Secondary-associated-Glucose Metabolism Disorders', 'Hemophilia A-reported-Hemorrhage', 'Headache Disorders, Secondary-reported-Hemorrhage', 'Central Nervous System Diseases-associated-Death', 'Death-associated-Central Nervous System Diseases', 'Glucose Metabolism Disorders-diagnosed-Hypertension', 'Glucose Metabolism Disorders-diagnosed-Diabetes Mellitus', 'Myelodysplastic Syndromes-comprise-Neoplasms', 'Myelodysplastic Syndromes-comprise-Cell Transformation, Viral', 'Myelodysplastic Syndromes-range-Thrombocytopenia', 'Neoplasms-comprise-Cell Transformation, Viral', 'Carcinoma, Hepatocellular-used-Acquired Immunodeficiency Syndrome', 'Carcinoma, Hepatocellular-remain-Acquired Immunodeficiency Syndrome', 'Acquired Immunodeficiency Syndrome-categorized-Hepatitis C', 'Myelodysplastic Syndromes-comprise-Death', 'Renal Insufficiency, Chronic-regarded-Cardiovascular Diseases', 'Renal Insufficiency, Chronic-reduce-Cardiovascular Diseases', 'Renal Insufficiency, Chronic-predict-Kidney Failure, Chronic', 'Cardiovascular Diseases-reflect-Renal Insufficiency, Chronic', 'Cardiovascular Diseases-predict-Kidney Failure, Chronic', 'Kidney Failure, Chronic-predict-Death', 'Renal Insufficiency, Chronic-progress-Kidney Failure, Chronic', 'Fetal Diseases-exposed-Multiple Sclerosis', 'Neoplasms-suffer-Cardiovascular Diseases', 'Obesity-suffer-Cardiovascular Diseases', 'IgA Vasculitis-complicated-Nephritis', 'IgA Vasculitis-complicated-Venous Thrombosis', 'IgA Vasculitis-considered-Kidney Diseases', 'Kidney Diseases-considered-Thrombosis', 'Cystinuria-consist-Kidney Diseases', 'Genetic Diseases, Inborn-consist-Kidney Diseases', 'Neoplasms-examine-Multiple Sclerosis', 'Sleep Apnea Syndromes-cause-Alzheimer Disease', 'Thyroid Diseases-include-Congenital Hypothyroidism', 'Thyroid Diseases-include-Autoimmune Diseases', 'Hyperthyroidism-observed-Neoplasms', 'Hypothyroidism-observed-Neoplasms', 'Neoplasms-compare-Thyroid Diseases', 'Thyroid Diseases-found-Neoplasms', 'Neoplasms-found-Thyroid Diseases', 'Opportunistic Infections-enable-Hodgkin Disease', 'Mitochondrial Diseases-represent-Huntington Disease', 'Mitochondrial Diseases-represent-Cerebral Infarction', 'Glucose Intolerance-manifest-Diabetes, Gestational', 'Diabetes, Gestational-play-Diabetes Mellitus', 'Diabetes, Gestational-become-Obesity', 'Kidney Diseases-belong-Hypertension', 'Colitis, Ulcerative-include-Colorectal Neoplasms', 'Hypertension-increase-Dementia', 'Heart Failure-associated-Bruxism', 'Bruxism-associated-Heart Failure', 'Diarrhea-cause-Death', 'Fractures, Bone-ende-Death', 'Neoplasms-prove-Hemangiosarcoma', 'Neoplasms-differentiate-Hemangioma', 'Neoplasms-differentiate-Hemangioblastoma', 'Neoplasms-differentiate-Sarcoma, Kaposi', 'Neoplasms-differentiate-Carcinoma, Squamous Cell', 'Neoplasms-differentiate-Melanoma', 'Cerebrovascular Disorders-interact-Alzheimer Disease', 'Cerebrovascular Disorders-emerge-Alzheimer Disease', 'Astigmatism-related-Corneal Diseases', 'Dementia, Vascular-caused-Neurodegenerative Diseases', 'Dementia, Vascular-caused-Atherosclerosis', 'Dementia, Vascular-caused-Arteriosclerosis', 'Lymphoma-cause-Dementia', 'Dementia, Vascular-caused-Arteriolosclerosis', 'Dementia, Vascular-caused-Cerebral Amyloid Angiopathy', 'Dementia, Vascular-cause-Infarction', 'Dementia-go-Aneurysm', 'Renal Insufficiency, Chronic-calculate-Kidney Diseases', 'Stroke-strengthen-Cardiovascular Diseases', 'Proteinuria-calculate-Kidney Diseases', 'Death-strengthen-Cardiovascular Diseases', 'Myocardial Infarction-resuscitate-Heart Arrest', 'Stroke-resuscitate-Heart Arrest', 'Heart Arrest-include-Cardiovascular Diseases', 'Diabetic Neuropathies-affect-Diabetes Mellitus', 'Diabetes Mellitus-involve-Nervous System Diseases', 'Hematoma-associated-Hematoma, Subdural, Chronic', 'Hematoma, Subdural, Chronic-associated-Hematoma', 'Alzheimer Disease-determined-Death', 'Exanthema-treated-Infections', 'Exanthema-investigate-IgA Vasculitis', 'Infections-investigate-IgA Vasculitis', 'Dry Eye Syndromes-detect-Dehydration', 'Drug-Related Side Effects and Adverse Reactions-experience-Leukemia, Myelogenous, Chronic, BCR-ABL Positive', 'Leukemia, Myelogenous, Chronic, BCR-ABL Positive-experience-Anemia', 'Fasciitis, Necrotizing-include-Infections', 'Shock, Septic-distinguish-Infections', 'Aneurysm-emphasize-Aortic Aneurysm, Abdominal', 'Tuberculosis-include-Musculoskeletal Diseases', 'Neoplasms-co-inject-Breast Neoplasms', 'Neoplasms-isolated-Breast Neoplasms', 'Mitochondrial Diseases-contribute-Muscular Atrophy', 'Cystic Fibrosis-complicated-Pulmonary Embolism', 'Obesity-prevent-Chronic Disease', 'Infections-resemble-Bronchiolitis', 'Long QT Syndrome-associated-Kidney Failure, Chronic', 'Kidney Failure, Chronic-associated-Long QT Syndrome', 'Long QT Syndrome-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-Long QT Syndrome', 'Venous Thrombosis-found-Pulmonary Embolism', 'Brain Injuries, Traumatic-include-Venous Thromboembolism', 'Renal Insufficiency, Chronic-exposed-Metabolic Diseases', 'Venous Thrombosis-lead-Obesity', 'Renal Insufficiency, Chronic-exposed-Vascular Remodeling', 'Calcinosis-linked-Metabolic Diseases', 'Calcinosis-linked-Renal Insufficiency, Chronic', 'Vascular Remodeling-linked-Metabolic Diseases', 'Vascular Remodeling-associated-Renal Insufficiency, Chronic', 'Renal Insufficiency, Chronic-associated-Vascular Remodeling', 'Metabolic Diseases-associated-Renal Insufficiency, Chronic', 'Renal Insufficiency, Chronic-associated-Metabolic Diseases', 'Sublingual Gland Neoplasms-progress-Dyspnea', 'Pharyngeal Diseases-progress-Dyspnea', 'Death-include-Endocarditis', 'Mitochondrial Diseases-believed-Neurodegenerative Diseases', 'Urinary Bladder, Overactive-compared-Metabolic Syndrome', 'Urinary Bladder, Overactive-associated-Metabolic Syndrome', 'Metabolic Syndrome-associated-Urinary Bladder, Overactive', 'Wounds and Injuries-assess-Spinal Injuries', 'Wounds and Injuries-assess-Spinal Cord Injuries', 'Infections-followed-Dental Leakage', 'Infections-followed-Hemorrhage', 'Spinal Cord Injuries-suffer-Wounds, Nonpenetrating', 'Blood Platelet Disorders-encountered-Renal Insufficiency, Chronic', 'Hemorrhage-encountered-Renal Insufficiency, Chronic', 'Anemia-associated-Genetic Diseases, Inborn', 'Genetic Diseases, Inborn-associated-Anemia', 'Anemia-range-Genetic Diseases, Inborn', 'Anemia-range-Neoplasms', 'Neoplasms-remain-Obesity', 'Osteoarthritis-include-Rheumatic Fever', 'Prostatic Hyperplasia-cause-Airway Obstruction', 'Prostatic Hyperplasia-cause-Urinary Bladder Neck Obstruction', 'Urinary Bladder Diseases-associated-Inflammation', 'Inflammation-associated-Urinary Bladder Diseases', 'Obesity-involved-Heart Failure', 'Obesity-involved-Pulmonary Disease, Chronic Obstructive', 'Anemia-involved-Heart Failure', 'Anemia-involved-Pulmonary Disease, Chronic Obstructive', 'Kidney Diseases-involved-Heart Failure', 'Kidney Diseases-involved-Pulmonary Disease, Chronic Obstructive', 'Thyroid Diseases-involved-Heart Failure', 'Thyroid Diseases-involved-Pulmonary Disease, Chronic Obstructive', 'Heart Failure-involved-Pulmonary Disease, Chronic Obstructive', 'Nerve Degeneration-underlie-Diabetes Mellitus', 'Nerve Degeneration-underlie-Neurodegenerative Diseases', 'Vision Disorders-describe-Hallucinations', 'Weight Loss-induced-Dehydration', 'Sarcopenia-refer-Muscle Weakness', 'HIV Infections-found-Fractures, Bone', 'Hypogonadism-suggest-HIV Infections', 'Fractures, Bone-identify-HIV Infections', 'Fractures, Bone-study-Alzheimer Disease', 'Kidney Papillary Necrosis-associated-Neoplasms', 'Neoplasms-associated-Kidney Papillary Necrosis', 'Parkinson Disease-function-Parkinson Disease, Secondary', 'Parkinson Disease, Secondary-improve-Neurologic Manifestations', 'Parkinson Disease-represent-Retinal Degeneration', 'Meningitis-conduct-Infections', 'Inflammation-induce-Bacteremia', 'Myopia-experience-Ocular Hypertension', 'Blood Coagulation Disorders-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-Blood Coagulation Disorders', 'Blood Coagulation Disorders-associated-Dyslipidemias', 'Dyslipidemias-associated-Blood Coagulation Disorders', 'Atherosclerosis-translated-Aortic Diseases', 'Myasthenia Gravis-trigger-Infections', 'Dementia-associate-Alzheimer Disease', 'Alzheimer Disease-associate-Dementia', 'Refractive Errors-observed-Glycogen Storage Disease Type II', 'Atrophy-found-Glycogen Storage Disease Type II', 'Hypertension-become-Obesity', 'Diabetes Mellitus-mediate-Muscular Diseases', 'Wounds and Injuries-respond-Hypovolemia', 'Hemorrhage-respond-Hypovolemia', 'Pulmonary Disease, Chronic Obstructive-detect-Asthma', 'Pulmonary Disease, Chronic Obstructive-compared-Asthma', 'Cough-include-Pulmonary Disease, Chronic Obstructive', 'Chest Pain-include-Pulmonary Disease, Chronic Obstructive', 'Pulmonary Disease, Chronic Obstructive-include-Asthma', 'Dyspnea-include-Asthma', 'Cough-include-Asthma', 'Chest Pain-include-Asthma', 'Glioblastoma-identified-Malocclusion', 'Glioblastoma-use-Malocclusion', 'Urinary Incontinence-accompanied-Nocturia', 'Stroke-performed-Infarction, Middle Cerebral Artery', 'Obesity-become-Cardiovascular Diseases', 'Metabolic Syndrome-become-Cardiovascular Diseases', 'Diabetes Mellitus-become-Cardiovascular Diseases', 'Nervous System Diseases-look-Dementia', 'Diabetes Mellitus, Type 1-increase-Abdominal Pain', 'Diabetes Mellitus, Type 1-increase-Diarrhea', 'Dystonia-associated-End Stage Liver Disease', 'End Stage Liver Disease-associated-Dystonia', 'Aneurysm, Infected-include-Atherosclerosis', 'Bacteremia-considered-Infections', 'Hypothyroidism-treat-Myxedema', 'Hypothyroidism-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-Hypothyroidism', 'Carcinoma, Hepatocellular-developed-Liver Cirrhosis, Alcoholic', 'Focal Infection-associated-Death', 'Death-associated-Focal Infection', 'Intracranial Arterial Diseases-prevent-Cardiovascular Diseases', 'Intracranial Arterial Diseases-increase-Cardiovascular Diseases', 'Neoplasms-compare-Leukemia', 'Neoplasms-compare-Myelodysplastic Syndromes', 'Leukemia-compare-Myelodysplastic Syndromes', 'Hodgkin Disease-continue-Death', 'Obesity-display-Infections', 'Obesity-display-Kidney Diseases', 'Obesity-display-Urinary Tract Infections', 'Obesity-display-Hypotension', 'Hypertension-investigated-Coronary Artery Disease', 'Death-provide-Diabetes Mellitus', 'Osteoarthritis-provide-Pain', 'Osteoporosis-associated-Osteomalacia', 'Osteomalacia-associated-Osteoporosis', 'Apnea-cause-Sleep Apnea, Obstructive', 'Pulmonary Disease, Chronic Obstructive-associated-Neoplasms', 'Neoplasms-associated-Pulmonary Disease, Chronic Obstructive', 'Tuberculosis-include-Spinal Fractures', 'Neurologic Manifestations-associated-Spinal Fractures', 'Spinal Fractures-associated-Neurologic Manifestations', 'Stroke-relate-Atrial Fibrillation', 'Death-relate-Atrial Fibrillation', 'Atrial Fibrillation-relate-Dementia', 'Atrial Fibrillation-control-Stroke', 'HIV Infections-followed-Hypogonadism', 'HIV Infections-associated-Hypogonadism', 'Hypogonadism-associated-HIV Infections', 'Hip Fractures-assessed-Dementia', 'Death-related-Heart Failure', 'Ischemia-support-Spinal Cord Injuries', 'Emphysema-protect-Inflammation', 'Occupational Diseases-protected-Mesothelioma', 'Asthenia-occur-Sarcoidosis', 'Uveitis-occur-Sarcoidosis', 'Skin Diseases-occur-Sarcoidosis', 'Death-related-Mycetoma', 'Alzheimer Disease-constitute-Death', 'Communicable Diseases-impact-Death', 'Stroke-suffer-Seizures', 'Malnutrition-caused-Deglutition Disorders', 'Malnutrition-lead-Sarcopenia', 'Deglutition Disorders-lead-Sarcopenia', 'Malnutrition-induce-Sarcopenia', 'Sarcopenia-result-Deglutition Disorders', 'Parasitemia-lead-Death', 'Death-comprise-Cardiovascular Diseases', 'Hepatitis C-survive-Acquired Immunodeficiency Syndrome', 'Infections-survive-Acquired Immunodeficiency Syndrome', 'Malnutrition-suffer-Chronic Disease', 'Vascular Calcification-review-Renal Insufficiency, Chronic', 'Hypertension-contribute-Dementia', 'Hypertension-contribute-Stroke', 'Neurodegenerative Diseases-affect-Fragile X Syndrome', 'HIV Infections-increase-Cerebrovascular Disorders', 'HIV Infections-increase-Alzheimer Disease', 'Memory Disorders-include-Atrophy', 'Memory Disorders-predominate-Sclerosis', 'Memory Disorders-predominate-Atrophy', 'Sclerosis-include-Atrophy', 'Autoimmune Diseases-suspected-Myeloproliferative Disorders', 'Nephrolithiasis-described-Cushing Syndrome', 'Glucose Intolerance-include-Metabolic Syndrome', 'Thrombophilia-include-Metabolic Syndrome', 'Bone Diseases-associated-Cushing Syndrome', 'Cushing Syndrome-associated-Bone Diseases', 'Dyspnea-measured-Pulmonary Disease, Chronic Obstructive', 'Stroke-associate-Coronary Artery Disease', 'Coronary Artery Disease-associate-Stroke', 'Stroke-remain-Coronary Artery Disease', 'Stroke-remain-Hypertension', 'Alzheimer Disease-conceptualized-Dementia', 'Coronary Artery Disease-do-Cardiomyopathies', 'Stroke-do-Hypertension', 'Stroke-do-Cardiomyopathies', 'Hypertension-do-Cardiomyopathies', 'Atrial Fibrillation-do-Cardiomyopathies', 'Atrophy-surrounded-Neurogenic Inflammation', 'Wounds and Injuries-related-Brain Injuries', 'Brain Injuries-include-Muscle Spasticity', 'Brain Injuries-involve-Muscle Spasticity', 'Deglutition Disorders-include-Brain Injuries', 'Deglutition Disorders-involve-Brain Injuries', 'Brain Injuries-include-Urinary Incontinence', 'Brain Injuries-involve-Urinary Incontinence', 'Brain Injuries-include-Diabetes Mellitus', 'Brain Injuries-involve-Diabetes Mellitus', 'Pain-include-Brain Injuries', 'Pain-involve-Brain Injuries', 'Endophthalmitis-depend-Ocular Hypertension', 'Endophthalmitis-depend-Inflammation', 'Heart Diseases-associated-Ischemia', 'Ischemia-associated-Heart Diseases', 'Stroke-recognised-Hemorrhage', 'Infections-control-Neoplasms', 'Osteoporosis-defined-Femoral Neck Fractures', 'Fever-develop-Cough', 'Blindness-compare-Glaucoma, Open-Angle', 'Blindness-found-Glaucoma, Open-Angle', 'Vision Disorders-compare-Glaucoma, Open-Angle', 'Mitochondrial Diseases-lead-Cardiac Output, Low', 'Venous Thromboembolism-reported-Death', 'Venous Thromboembolism-associated-Central Nervous System Neoplasms', 'Central Nervous System Neoplasms-associated-Venous Thromboembolism', 'Alcoholism-associated-Neurologic Manifestations', 'Neurologic Manifestations-associated-Alcoholism', 'Angiodysplasia-present-Ulcer', 'Angiodysplasia-present-Polyps', 'Alzheimer Disease-underlie-Aneurysm', 'Neoplasms-occur-Prostatic Neoplasms', 'Renal Insufficiency, Chronic-develop-Acute Kidney Injury', 'Chronic Kidney Disease-Mineral and Bone Disorder-develop-Acute Kidney Injury', 'Kidney Diseases-develop-Acute Kidney Injury', 'Vestibular Diseases-present-Vertigo', 'Cataract-attack-Glaucoma', 'Vision Disorders-attack-Glaucoma', 'Fragile X Syndrome-characterized-Skin Diseases', 'Ear Diseases-hear-Hearing Loss', 'Hearing Loss-detected-Otitis', 'Pain-associated-Neurodegenerative Diseases', 'Neurodegenerative Diseases-associated-Pain', 'Dementia-result-Pain', 'Anemia, Iron-Deficiency-caused-Postpartum Hemorrhage', 'Anemia-caused-Postpartum Hemorrhage', 'Dementia-related-Parkinson Disease', 'Obesity-increase-Glucose Metabolism Disorders', 'Liver Failure-correlated-Infections', 'Liver Failure-correlated-Carcinoma, Hepatocellular', 'Carcinoma, Hepatocellular-show-Liver Failure', 'Infections-show-Liver Failure', 'Infections-derived-Liver Failure', 'Neuroblastoma-sensitize-Necrosis', 'Liver Failure-associated-Infections', 'Infections-associated-Liver Failure', 'Neoplasms-benefit-Primary Ovarian Insufficiency', 'Death-listed-Gastroenteritis', 'Atrial Fibrillation-found-Myocardial Infarction', 'Atrial Fibrillation-found-Hypertension', 'Atrial Fibrillation-found-Angina Pectoris', 'Atrial Fibrillation-found-Diabetes Mellitus', 'Cartilage Diseases-repair-Osteoarthritis', 'Ulcer-perform-Hemorrhage', 'Pituitary Neoplasms-supposed-Death', 'Pituitary Neoplasms-function-Death', 'Ulcer-show-Constriction, Pathologic', 'Fractures, Bone-related-Death', 'Vascular Calcification-recommend-Coronary Artery Disease', 'Vascular Calcification-describe-Atherosclerosis', 'Vascular Calcification-include-Atherosclerosis', 'Vascular Calcification-play-Diabetes Mellitus', 'Stroke-characterized-Mitochondrial Diseases', 'Mitochondrial Diseases-characterized-Seizures', 'Mitochondrial Diseases-characterized-Migraine Disorders', 'Mitochondrial Diseases-characterized-Vomiting', 'Infertility, Female-occur-Heart Failure', 'Hepatitis C-tend-Liver Cirrhosis', 'Hepatitis C-evolve-Liver Cirrhosis', 'Obesity-affect-Liver Diseases', 'Diabetes Mellitus-affect-Liver Diseases', 'Fatty Liver-affect-Liver Diseases', 'Metabolic Diseases-affect-Liver Diseases', 'Hypotension, Orthostatic-predict-Death', 'Hypotension-predict-Death', 'Drug Hypersensitivity-predict-Death', 'Hypotension, Orthostatic-remain-Death', 'Hypotension, Orthostatic-used-Death', 'Dementia-include-Plaque, Amyloid', 'Dementia-include-Sclerosis', 'Cerebrovascular Disorders-reduce-Dementia', 'Dementia-include-Cerebral Infarction', 'Dementia-include-Cardiovascular Diseases', 'Dementia-influence-Cardiovascular Diseases', 'Alzheimer Disease-correlated-Dementia', 'Hypertension-influence-Cardiovascular Diseases', 'Neuromuscular Diseases-cause-Paralysis', 'Anophthalmos-considered-Vision Disorders', 'Anophthalmos-considered-Blindness', 'Neuromuscular Diseases-include-Motor Neuron Disease', 'Neuromuscular Diseases-afflict-Motor Neuron Disease', 'Cerebral Infarction-detected-Stroke', 'Metabolic Diseases-associated-Cerebral Infarction', 'Cerebral Infarction-associated-Metabolic Diseases', 'Amenorrhea-classified-Oligomenorrhea', 'Infarction-considered-Neuromyelitis Optica', 'Ulcer-reported-Spinal Cord Injuries', 'Hemorrhage-associated-Cerebral Amyloid Angiopathy', 'Cerebral Amyloid Angiopathy-associated-Hemorrhage', 'Stroke-discussed-Cerebral Amyloid Angiopathy', 'Cerebral Amyloid Angiopathy-associated-Hematoma', 'Hematoma-associated-Cerebral Amyloid Angiopathy', 'Reperfusion Injury-attenuate-Stroke', 'Hemorrhage-discussed-Postoperative Hemorrhage', 'Cerebral Amyloid Angiopathy-associated-Coma', 'Coma-associated-Cerebral Amyloid Angiopathy', 'Nervous System Diseases-caused-Reperfusion Injury', 'Metabolic Syndrome-predict-Glucose Intolerance', 'Metabolic Syndrome-predict-Obesity', 'Metabolic Syndrome-predict-Diabetes Mellitus, Type 2', 'Glucose Intolerance-predict-Diabetes Mellitus, Type 2', 'Obesity-predict-Diabetes Mellitus, Type 2', 'Diabetes Mellitus-predicted-Metabolic Syndrome', 'Liver Cirrhosis, Biliary-associated-Fatigue', 'Fatigue-associated-Liver Cirrhosis, Biliary', 'Hypertension-associated-Asthma', 'Asthma-associated-Hypertension', 'Myocardial Infarction-associated-Pulmonary Disease, Chronic Obstructive', 'Pulmonary Disease, Chronic Obstructive-associated-Myocardial Infarction', 'Myocardial Infarction-associated-Asthma', 'Asthma-associated-Myocardial Infarction', 'Death-remain-Colorectal Neoplasms', 'Dementia-observed-Pain', 'Dementia-cause-Pain', 'Nervous System Diseases-caused-Wounds and Injuries', 'Hemorrhage-compare-Aneurysm', 'Neoplasms-induce-Dermatitis, Phototoxic', 'Neoplasms-promote-Skin Diseases', 'Neoplasms-promote-Skin Neoplasms', 'Ventricular Dysfunction, Left-correspond-Renal Insufficiency, Chronic', 'Anemia-associated-Myocardial Infarction', 'Myocardial Infarction-associated-Anemia', 'Anemia-result-Thrombosis', 'Mitochondrial Diseases-identified-Cardiovascular Diseases', 'Mitochondrial Diseases-identified-Diabetes Mellitus', 'Mitochondrial Diseases-identified-Heart Failure', 'Diabetes Mellitus-manifest-Proteinuria', 'Cardiac Output, Low-increased-Osteoporotic Fractures', 'Neoplasms-suggest-Adenoma', 'Dermatitis-related-Urinary Incontinence', 'Neoplasms-suggest-Acromegaly', 'Neoplasms-consist-Stomach Neoplasms', 'Neoplasms-need-Esophageal Neoplasms', 'Respiratory Tract Infections-develop-Pneumonia', 'Pneumonia-result-Infections', 'Hypertension, Pulmonary-distinguish-Hypotension', 'Hypertension, Pulmonary-distinguish-Heart Failure', 'Diarrhea-become-Infections', 'Diarrhea-become-Death', 'Kidney Diseases-attributed-Hypertension', 'Kidney Diseases-attributed-Diabetes Mellitus', 'Tricuspid Valve Insufficiency-associated-Atrial Fibrillation', 'Atrial Fibrillation-associated-Tricuspid Valve Insufficiency', 'Colonic Neoplasms-maintain-Neoplasms', 'Acute Kidney Injury-include-Chronic Disease', 'Reperfusion Injury-contribute-Multiple Organ Failure', 'Hypertension, Pulmonary-show-Death', 'Hypertension, Pulmonary-associated-Hemolysis', 'Hemolysis-associated-Hypertension, Pulmonary', 'Hypertension, Pulmonary-associated-Renal Insufficiency', 'Renal Insufficiency-associated-Hypertension, Pulmonary', 'Hypertension, Pulmonary-associated-Liver Failure', 'Liver Failure-associated-Hypertension, Pulmonary', 'Pelvic Floor Disorders-relieve-Constipation', 'Pain-affected-Dementia', 'Pain-modified-Dementia', 'Genetic Diseases, Inborn-comprise-Ataxia Telangiectasia', 'Genetic Diseases, Inborn-known-Ataxia Telangiectasia', 'Genetic Diseases, Inborn-comprise-Nijmegen Breakage Syndrome', 'Genetic Diseases, Inborn-comprise-Werner Syndrome', 'Genetic Diseases, Inborn-known-Fanconi Anemia', 'Genetic Diseases, Inborn-known-Xeroderma Pigmentosum', 'Genetic Diseases, Inborn-comprise-Cockayne Syndrome', 'Genetic Diseases, Inborn-known-Trichothiodystrophy Syndromes', 'Hypercalcemia-occur-Hypercalciuria', 'Hemophilia A-include-Joint Diseases', 'Brain Ischemia-review-Dementia', 'Epididymitis-lead-Infertility, Female', 'Alzheimer Disease-generate-Brain Diseases', 'Disease-generate-Brain Diseases', 'Hypogonadism-associated-Fatigue', 'Fatigue-associated-Hypogonadism', 'Hypogonadism-associated-Heart Failure', 'Heart Failure-associated-Hypogonadism', 'Hemorrhage-selected-Dementia', 'Arthritis, Rheumatoid-reduce-Inflammation', 'Atrophy-examined-Amnesia', 'Alzheimer Disease-use-Vision Disorders', 'Chronic Disease-protect-Neoplasms', 'Chronic Disease-protect-Cardiovascular Diseases', 'Chronic Disease-protect-Diabetes Mellitus', 'Neoplasms-include-Cardiovascular Diseases', 'Endometriosis-develop-Atherosclerosis', 'Genital Diseases, Female-develop-Atherosclerosis', 'Glaucoma-represent-Central Nervous System Diseases', 'Glaucoma-characterized-Neurodegenerative Diseases', 'Glaucoma-characterized-Blindness', 'REM Sleep Behavior Disorder-represented-Parkinson Disease', 'Drug-Related Side Effects and Adverse Reactions-reduced-Neuroblastoma', 'Death-categorized-Communicable Diseases', 'Adenocarcinoma, Mucinous-cause-Superior Vena Cava Syndrome', 'Neoplasms-develop-Cardiomyopathies', 'Colorectal Neoplasms-develop-Cardiomyopathies', 'Neoplasms-increase-Neoplasm Metastasis', 'Inflammation-investigate-Arthritis', 'Ankylosis-investigate-Arthritis', 'Stroke-increased-Heart Failure, Systolic', 'Ovarian Neoplasms-follow-Infertility, Female', 'Ovarian Neoplasms-cause-Infertility, Female', 'Pneumonia-admitted-Brain Diseases, Metabolic', 'Hyperuricemia-associated-Parkinson Disease', 'Parkinson Disease-associated-Hyperuricemia', 'Hypoalbuminemia-predict-Death', 'Dementia-exposed-Malnutrition', 'Dementia-include-Malnutrition', 'Dementia-exposed-Death', 'Neoplasms-continue-Bone Diseases', 'Neoplasms-continue-Osteoporosis', 'Cardiovascular Diseases-associated-Sleep Deprivation', 'Sleep Deprivation-associated-Cardiovascular Diseases', 'Neoplasms-improve-Neoplasm Metastasis', 'Stroke-associated-Sleep Deprivation', 'Sleep Deprivation-associated-Stroke', 'Diabetes Mellitus-associated-Sleep Deprivation', 'Sleep Deprivation-associated-Diabetes Mellitus', 'Arthritis-associated-Sleep Deprivation', 'Sleep Deprivation-associated-Arthritis', 'Coinfection-cause-Multiple Myeloma', 'Coinfection-cause-Kidney Failure, Chronic', 'Heredodegenerative Disorders, Nervous System-associated-Neurotoxicity Syndromes', 'Neurotoxicity Syndromes-associated-Heredodegenerative Disorders, Nervous System', 'Fractures, Bone-monitor-Osteoporosis', 'Asthma-identified-Malocclusion', 'Neoplasms-include-Sleep Initiation and Maintenance Disorders', 'Genetic Diseases, Inborn-recapitulate-Neurodegenerative Diseases', 'Hearing Loss, Central-considered-Disease', 'Colitis, Ischemic-associated-Hyperuricemia', 'Hyperuricemia-associated-Colitis, Ischemic', 'Trigeminal Neuralgia-reveal-Seizures', 'Trigeminal Neuralgia-reveal-Status Epilepticus', 'Pneumococcal Infections-divided-Neoplasm Invasiveness', 'Weight Loss-undertake-Death', 'Kidney Diseases-linked-Hypertension', 'Diabetes Mellitus-linked-Hypertension', 'Gastroesophageal Reflux-pay-Spinal Diseases', 'Gastroesophageal Reflux-include-Obesity', 'Gastroenteritis-cause-Infections', 'Hernia, Ventral-return-Death', 'Pneumonia-return-Death', 'Pulmonary Embolism-return-Death', 'Infections-return-Death', 'Myocardial Infarction-return-Death', 'Venous Thrombosis-return-Death', 'Sepsis-return-Death', 'Nerve Degeneration-associate-Parkinson Disease, Secondary', 'Parkinson Disease, Secondary-associate-Nerve Degeneration', 'Nerve Degeneration-related-Parkinson Disease, Secondary', 'Parkinson Disease, Secondary-mediate-Nerve Degeneration', 'Gout-affect-Musculoskeletal Diseases', 'Carotid Stenosis-associated-Neurodegenerative Diseases', 'Neurodegenerative Diseases-associated-Carotid Stenosis', 'Carotid Stenosis-associated-Inflammation', 'Inflammation-associated-Carotid Stenosis', 'Carotid Stenosis-associated-Blepharitis', 'Blepharitis-associated-Carotid Stenosis', 'Carotid Stenosis-associated-Dry Eye Syndromes', 'Dry Eye Syndromes-associated-Carotid Stenosis', 'Syncope-fall-Vertigo', 'Headache Disorders, Secondary-reported-Nervous System Diseases', 'Myelodysplastic Syndromes-remain-Infections', 'Infections-develop-Fractures, Malunited', 'Brain Infarction-define-Stroke', 'Brain Infarction-assessed-Stroke', 'Hearing Loss-develop-Alzheimer Disease', 'Skin Neoplasms-display-Growth Disorders', 'Nervous System Diseases-display-Growth Disorders', 'Metabolic Syndrome-portend-Chronic Disease', 'Osteoporosis-receive-Osteoporotic Fractures', 'Hemochromatosis-lead-Carcinogenesis', 'Neoplasms-see-Hemochromatosis', 'Foreign Bodies-cause-Pneumonia', 'Hepatomegaly-associated-Alzheimer Disease', 'Alzheimer Disease-associated-Hepatomegaly', 'Hepatomegaly-seen-Alzheimer Disease', 'Dementia-account-Stroke', 'Dementia-attributed-Stroke', 'Infections-treated-Inflammation', 'Tooth Injuries-treated-Inflammation', 'Memory Disorders-share-Sleep Initiation and Maintenance Disorders', 'Fractures, Bone-fall-Athletic Injuries', 'Thrombosis-prevent-Hemorrhage', 'Sleep Apnea, Obstructive-compare-Delirium', 'Sleep Apnea, Obstructive-experience-Delirium', 'Dyspepsia-treat-Stroke', 'Hemostatic Disorders-include-Hemorrhage', 'Cardiovascular Diseases-contribute-Autoimmune Diseases', 'Autoimmune Diseases-contribute-Atherosclerosis', 'Autoimmune Diseases-height-Atherosclerosis', 'Lipid Metabolism Disorders-height-Atherosclerosis', 'Lupus Erythematosus, Systemic-affect-Atherosclerosis', 'Ischemia-graded-Coronary Artery Disease', 'Primary Graft Dysfunction-require-Takotsubo Cardiomyopathy', 'Primary Graft Dysfunction-show-Cardiac Output, Low', 'Takotsubo Cardiomyopathy-show-Cardiac Output, Low', 'Neoplasms-outline-Digestive System Neoplasms', 'Anemia-predict-Inflammation', 'Anemia-predict-Chronic Disease', 'HIV Infections-reported-Acquired Immunodeficiency Syndrome', 'Death-sustain-Pelvic Neoplasms', 'Pelvic Neoplasms-include-Fractures, Bone', 'Lymphoma, T-Cell, Peripheral-develop-Infections', 'Fatigue-improve-Neoplasms', 'Atherosclerosis-cause-Malformations of Cortical Development, Group II', 'Cardiac Output, Low-considered-Obesity', 'Communicable Diseases-include-Dementia', 'Tooth Loss-control-Calculi', 'Obesity-present-Pain', 'Colorectal Neoplasms-present-Neoplasms', 'Colorectal Neoplasms-develop-Neoplasms, Second Primary', 'Neoplasms-develop-Neoplasms, Second Primary', 'Colorectal Neoplasms-increase-Neoplasms', 'Heart Diseases-affect-Myocarditis', 'Death-compare-Myocarditis', 'Acute Kidney Injury-induce-Critical Illness', 'Acute Kidney Injury-induce-Wounds and Injuries', 'Acute Kidney Injury-induce-Kidney Diseases', 'Wounds and Injuries-result-Kidney Diseases', 'Inflammation-improve-Infections', 'Arrhythmias, Cardiac-indicate-Heart Arrest', 'Arrhythmias, Cardiac-confer-Myocardial Infarction', 'Heart Arrest-confer-Myocardial Infarction', 'Heart Failure-combined-Cardiovascular Diseases', 'Rhinitis-tend-Drug Hypersensitivity', 'Neoplasm Metastasis-affect-Neoplasms', 'Metabolic Diseases-include-Acquired Immunodeficiency Syndrome', 'Metabolic Diseases-include-Death', 'Heart Diseases-associated-Long QT Syndrome', 'Long QT Syndrome-associated-Heart Diseases', 'Heart Diseases-yield-Long QT Syndrome', 'Heart Diseases-associated-Tachycardia, Ventricular', 'Tachycardia, Ventricular-associated-Heart Diseases', 'Heart Diseases-associated-Brugada Syndrome', 'Brugada Syndrome-associated-Heart Diseases', 'Heart Diseases-yield-Brugada Syndrome', 'Heart Diseases-lie-Arrhythmias, Cardiac', 'Heart Diseases-lie-Death', 'Ulcer-occur-Chronic Disease', 'Long QT Syndrome-lie-Arrhythmias, Cardiac', 'Brugada Syndrome-lie-Arrhythmias, Cardiac', 'Arrhythmias, Cardiac-lie-Death', 'Metabolic Diseases-induced-Atherosclerosis', 'Atherosclerosis-induced-Cardiovascular Diseases', 'Diabetic Neuropathies-cause-Pain', 'Nervous System Diseases-cause-Pain', 'Diabetes Mellitus-proceed-Glucose Metabolism Disorders', 'Alzheimer Disease-decrease-Death', 'Airway Obstruction-identified-Gallstones', 'Aneurysm-underlie-Obesity', 'Drug-Related Side Effects and Adverse Reactions-reported-Edema', 'Drug-Related Side Effects and Adverse Reactions-reported-Cough', 'Drug-Related Side Effects and Adverse Reactions-reported-Exanthema', 'Drug-Related Side Effects and Adverse Reactions-reported-Diarrhea', 'Respiratory Tract Infections-contribute-Death', 'Blood Coagulation Disorders-include-Cardiovascular Diseases', 'Cardiovascular Diseases-related-Infections', 'Hypertension-associated-Hypoglycemia', 'Hypoglycemia-associated-Hypertension', 'Renal Insufficiency, Chronic-associated-Hypoglycemia', 'Hypoglycemia-associated-Renal Insufficiency, Chronic', 'Renal Insufficiency, Chronic-emerge-Death', 'Cerebral Hemorrhage-defined-Hemorrhage', 'Cerebral Hemorrhage-combined-Neurodegenerative Diseases', 'Cerebral Hemorrhage-lead-Stroke', 'Hemorrhage-combined-Neurodegenerative Diseases', 'Neurodegenerative Diseases-combined-Stroke', 'Dementia-use-Pain', 'Dementia, Vascular-associated-Parkinson Disease', 'Parkinson Disease-associated-Dementia, Vascular', 'Lewy Body Disease-associated-Parkinson Disease', 'Parkinson Disease-associated-Lewy Body Disease', 'Tauopathies-characterize-Alzheimer Disease', 'Nerve Degeneration-characterize-Alzheimer Disease', 'Osteosarcoma-contribute-Neoplasms', 'Hearing Loss-suffer-Urinary Incontinence', 'Coronary Artery Disease-control-Brain Infarction', 'Hypertension-take-Diabetes Mellitus', 'Pancreatic Neoplasms-associated-Papillomavirus Infections', 'Papillomavirus Infections-associated-Pancreatic Neoplasms', 'Melanoma-associated-Papillomavirus Infections', 'Papillomavirus Infections-associated-Melanoma', 'Adenocarcinoma-associated-Papillomavirus Infections', 'Papillomavirus Infections-associated-Adenocarcinoma', 'Death-enable-Neoplasms', 'Hypertrophy-hypertrophy-Constriction, Pathologic', 'Pain-used-Dementia', 'Death-classified-Stroke', 'Death-classified-Coronary Artery Disease', 'Death-classified-Cardiovascular Diseases', 'Death-classified-Pneumonia', 'Cartilage Diseases-caused-Neurodegenerative Diseases', 'Pain-reduce-Myocardial Infarction', 'Infectious Mononucleosis-associated-Lymphoma, Non-Hodgkin', 'Lymphoma, Non-Hodgkin-associated-Infectious Mononucleosis', 'Mitochondrial Diseases-observed-Alzheimer Disease', 'Mitochondrial Diseases-suffer-Alzheimer Disease', 'Mitochondrial Diseases-influence-Amyloidosis', 'Mitochondrial Diseases-influence-Alzheimer Disease', 'Alzheimer Disease-compare-Dementia, Vascular', 'Dementia-select-Dementia, Vascular', "Lupus Erythematosus, Systemic-influenced-Sjogren's Syndrome", 'Aneurysm-followed-Respiratory Tract Infections', 'Aneurysm-followed-Infections', 'Breast Neoplasms-become-Neoplasms', 'Breast Neoplasms-become-Carcinoma, Hepatocellular', 'Prostatic Neoplasms-become-Carcinoma, Hepatocellular', 'Inflammation-include-Acne Vulgaris', 'Tremor-produce-Parkinson Disease', 'Xerostomia-associated-Mouth Diseases', 'Mouth Diseases-associated-Xerostomia', 'Xerostomia-associated-Gingival Recession', 'Gingival Recession-associated-Xerostomia', 'Xerostomia-associated-Mycoses', 'Mycoses-associated-Xerostomia', 'Xerostomia-associated-Candidiasis', 'Candidiasis-associated-Xerostomia', 'Xerostomia-associated-Weight Gain', 'Weight Gain-associated-Xerostomia', 'Xerostomia-caused-Atrophy', 'Gingival Recession-include-Mouth Diseases', 'Mycoses-include-Mouth Diseases', 'Xerostomia-caused-Fibrosis', 'Candidiasis-include-Mouth Diseases', 'Periodontal Diseases-include-Mouth Diseases', 'Weight Gain-include-Mouth Diseases', 'Ataxia-present-Leukopenia', 'Ataxia-present-Anemia', 'Leukopenia-present-Lupus Erythematosus, Systemic', 'Anemia-present-Lupus Erythematosus, Systemic', 'Osteoporotic Fractures-diagnosed-Osteoporosis', 'Osteoporosis-seem-Diabetes Mellitus', 'Gastrointestinal Hemorrhage-increase-Death', 'Gastrointestinal Hemorrhage-burdened-Death', 'Death-observed-Gastrointestinal Hemorrhage', 'Sleepiness-associate-Sleep Wake Disorders', 'Sleep Wake Disorders-associate-Sleepiness', 'Sleepiness-compare-Sleep Wake Disorders', 'Dementia-recognized-Chronic Disease', 'Hypotension, Orthostatic-evaluate-Hypertension', 'Hypotension, Orthostatic-increase-Hypertension', 'Hypotension, Orthostatic-evaluate-Death', 'Drug Hypersensitivity-include-Death', 'Asthma-include-Death', 'Pulmonary Disease, Chronic Obstructive-include-Death', 'Pulmonary Fibrosis-include-Death', 'Lung Neoplasms-include-Death', 'Hypertension, Pulmonary-include-Death', 'Drug Hypersensitivity-include-Lung Diseases', 'Pulmonary Fibrosis-include-Lung Diseases', 'Lung Neoplasms-include-Lung Diseases', 'Death-appear-Neoplastic Syndromes, Hereditary', 'Neoplasms-provoke-Heart Arrest', 'Breast Neoplasms-increase-Obesity', 'Death-suffer-Weight Loss', 'Anorexia-suffer-Weight Loss', 'Cataract-impair-Vision Disorders', 'Cataract-caused-Anophthalmos', 'Lung Diseases-characterized-Inflammation', 'Cerebrovascular Disorders-predict-Dementia', 'Renal Insufficiency, Chronic-predict-Dementia', 'Cerebrovascular Disorders-correlate-Dementia', 'Diabetes Mellitus-correlate-Dementia', 'Renal Insufficiency, Chronic-correlate-Dementia', 'Hypertension-correlate-Dementia', 'Dementia-met-Alzheimer Disease', 'Critical Illness-affect-Diabetes Mellitus', 'Critical Illness-characterized-Pain', 'Critical Illness-characterized-Gangrene', 'Critical Illness-characterized-Hypotension', 'Wounds and Injuries-subside-Pain', 'Osteoporosis-include-Bone Diseases, Metabolic', 'Infections-controlled-Autoimmune Diseases', 'Myocardial Infarction-investigate-Atherosclerosis', 'Fractures, Bone-place-Wounds and Injuries', 'Alzheimer Disease-cause-Paralysis', 'Skin Diseases-consist-Neoplasms', 'Fractures, Open-follow-Death', 'Fractures, Open-examine-Death', 'Weight Loss-followed-Lung Diseases', 'Malnutrition-followed-Lung Diseases', 'Sarcopenia-expressed-Muscle Weakness', 'Fractures, Bone-achieve-Pain', 'Heart Arrest-contribute-Renal Insufficiency, Chronic', 'Renal Insufficiency, Chronic-used-Dementia', 'Tooth Loss-affect-Wounds and Injuries', 'Tooth Loss-affect-Anodontia', 'Tooth Loss-affect-Jaw Abnormalities', 'Osteoarthritis-base-Pain', 'Osteoarthritis-assessed-Pain', 'Dementia-characterized-Neurodegenerative Diseases', 'Weight Loss-become-Diabetes Mellitus', 'Weight Loss-become-Hypertension', 'Dementia-suggest-Headache Disorders, Secondary', 'Fractures, Bone-categorized-Respiratory Tract Infections', 'Stomach Neoplasms-accompanied-Infections', 'Ulcer-accompanied-Infections', 'Death-remain-Seizures', 'Alzheimer Disease-affect-Vision Disorders', 'Communicable Diseases-increase-Emphysema', 'Liver Diseases-increase-Emphysema', 'Parkinson Disease-affect-Vision Disorders', 'Fibrosis-increase-Emphysema', 'Carcinoma, Hepatocellular-increase-Emphysema', 'Spinal Cord Injuries-appear-Coronary Artery Disease', 'Spinal Cord Injuries-associated-Stroke', 'Stroke-associated-Spinal Cord Injuries', 'Death-remain-Pulmonary Embolism', 'Necrosis-associated-Neoplasms', 'Neoplasms-associated-Necrosis', 'Paraneoplastic Syndromes-necrotize-Necrosis', 'Paraneoplastic Syndromes-associated-Neoplasms', 'Neoplasms-associated-Paraneoplastic Syndromes', 'Necrosis-associated-Lymphoma', 'Lymphoma-associated-Necrosis', 'Hernia-complicated-Hematoma', 'Hernia-attributed-Airway Obstruction', 'Metabolic Diseases-exaggerate-Cardiovascular Diseases', 'Femoral Fractures-develop-Infections', 'Fractures, Bone-develop-Infections', 'Peripheral Nervous System Diseases-follow-Stroke', 'Neuromuscular Diseases-assess-Stroke', 'Ankle Fractures-undergo-Bone Diseases, Metabolic', 'Ankle Fractures-undergo-Diabetes Mellitus', 'Ankle Fractures-undergo-Peripheral Arterial Disease', 'Ankle Fractures-undergo-Kidney Failure, Chronic', 'Ankle Fractures-undergo-Renal Insufficiency, Chronic', 'Fractures, Bone-undergo-Bone Diseases, Metabolic', 'Fractures, Bone-undergo-Diabetes Mellitus', 'Fractures, Bone-undergo-Peripheral Arterial Disease', 'Fractures, Bone-undergo-Kidney Failure, Chronic', 'Fractures, Bone-undergo-Renal Insufficiency, Chronic', 'Hypertension-involve-Brain Diseases', 'Hypertension-involve-Stroke', 'Hypertension-involve-Renal Insufficiency', 'Cardiovascular Diseases-reduce-Diabetes Mellitus', 'Death-reduce-Diabetes Mellitus', 'Cardiovascular Diseases-contribute-Inflammation', 'Myocardial Infarction-include-Aneurysm', 'Intracranial Thrombosis-include-Aneurysm', 'Tinnitus-focus-Hearing Loss', 'Tinnitus-focus-Otitis', 'Alzheimer Disease-represent-Cerebral Amyloid Angiopathy', 'Infections-present-Death', 'Fractures, Bone-related-Bruxism', 'Metabolic Syndrome-increase-Hypothyroidism', 'Osteoporotic Fractures-result-Hip Fractures', 'Osteoporotic Fractures-identified-Hip Fractures', 'Osteoporotic Fractures-result-Fractures, Bone', 'Osteoporotic Fractures-identified-Fractures, Bone', 'Urinary Incontinence-include-Menstruation Disturbances', 'Urinary Incontinence-include-Pelvic Pain', 'Urinary Incontinence-include-Chronic Disease', 'Urinary Incontinence-include-Constipation', 'Fatty Liver-include-Liver Failure', 'Fibrosis-include-Liver Failure', 'Carcinoma, Hepatocellular-include-Liver Failure', 'Fatty Liver-undergo-Fibrosis', 'Fatty Liver-worsen-Fibrosis', 'Osteoporosis-associated-Neoplasms', 'Neoplasms-associated-Osteoporosis', 'Osteoporosis-link-Neoplasms', 'Neoplasms-noted-Osteoporosis', 'HIV Infections-established-Osteoporosis', 'Lymphoproliferative Disorders-caused-Immunologic Deficiency Syndromes', 'Lymphoproliferative Disorders-caused-Lupus Erythematosus, Systemic', 'Immunologic Deficiency Syndromes-caused-Lupus Erythematosus, Systemic', 'Fractures, Bone-reflect-Cardiac Output, Low', 'Arachnoiditis-contribute-Subdural Effusion', 'Arachnoiditis-cause-Hydrocephalus', 'Wounds and Injuries-contribute-Subdural Effusion', 'Wounds and Injuries-cause-Hydrocephalus', 'Subdural Effusion-cause-Hydrocephalus', 'Ataxia Telangiectasia-identify-Lipodystrophy', 'Atherosclerosis-benefit-Vascular Calcification', 'Progeria-discuss-Neurodegenerative Diseases', 'Q Fever-infect-Infections', 'Hemorrhage-associated-Cerebral Infarction', 'Cerebral Infarction-associated-Hemorrhage', 'Wounds and Injuries-experience-Syncope', 'Constipation-associated-Parkinson Disease', 'Parkinson Disease-associated-Constipation', 'Constipation-associated-Nerve Degeneration', 'Nerve Degeneration-associated-Constipation', 'Sleep Wake Disorders-associated-Nerve Degeneration', 'Nerve Degeneration-associated-Sleep Wake Disorders', 'Malaria-predispose-Hepatitis E', 'HIV Infections-predispose-Hepatitis E', 'Femoral Neck Fractures-associate-Death', 'Death-associate-Femoral Neck Fractures', 'Lymphoma-delineated-Lymphoma, B-Cell', 'Lymphoma-delineated-Burkitt Lymphoma', 'Muscular Diseases-increase-Muscle Hypertonia', 'Heart Failure-associated-Acute Disease', 'Acute Disease-associated-Heart Failure', 'Cardiac Output, Low-continue-Cardiovascular Diseases', 'Postpartum Hemorrhage-optimize-Anemia', 'Tuberculosis-include-Asthma', 'Lung Neoplasms-include-Asthma', 'Tuberculosis-include-Respiratory Tract Infections', 'Lung Neoplasms-include-Respiratory Tract Infections', 'Cardiovascular Diseases-compare-Kidney Diseases', 'Cardiovascular Diseases-remain-Kidney Diseases', 'Death-base-Diabetes Mellitus', 'Growth Disorders-develop-Cardiomyopathies', 'Growth Disorders-develop-Heart Diseases', 'Cardiomyopathies-develop-Heart Diseases', 'Diabetes Mellitus-follow-Pneumonia', 'Osteoporosis-complicated-Femoral Fractures', 'Sarcopenia-defined-Anorexia', 'Inflammation-defined-Anorexia', 'Atrophy-defined-Anorexia', 'Sarcopenia-shown-Infections', 'Sarcopenia-shown-Ulcer', 'Ulcer-increase-Death', 'Alzheimer Disease-include-Olfaction Disorders', 'Heart Diseases-examine-Neoplasms', 'Heart Diseases-examine-Diabetes Mellitus', 'Neoplasms-examine-Diabetes Mellitus', 'Pain-associated-Gastrointestinal Diseases', 'Gastrointestinal Diseases-associated-Pain', 'Pain-associated-Dyspepsia', 'Dyspepsia-associated-Pain', 'Pain-associated-Hemorrhage', 'Hemorrhage-associated-Pain', 'Osteoarthritis-associated-Dyspepsia', 'Dyspepsia-associated-Osteoarthritis', 'Osteoarthritis-associated-Ulcer', 'Ulcer-associated-Osteoarthritis', 'Metabolic Syndrome-evaluated-Pulmonary Disease, Chronic Obstructive', 'Gastrointestinal Diseases-manifest-Dyspepsia', 'Gastrointestinal Diseases-manifest-Ulcer', 'Gastrointestinal Diseases-manifest-Hemorrhage', 'Weight Gain-compare-Seizures', 'Hypertension-make-Cardiovascular Diseases', 'Hypercholesterolemia-make-Cardiovascular Diseases', 'Diabetes Mellitus-make-Cardiovascular Diseases', 'Brain Neoplasms-associated-Delirium', 'Delirium-associated-Brain Neoplasms', 'Pain-define-Osteoarthritis', 'Hypertension-based-Diabetes Mellitus', 'Hypertension-based-Stroke', 'Hypertension-based-Dementia', 'Nephritis, Interstitial-result-Renal Insufficiency, Chronic', 'Pain-function-Osteoarthritis', 'Heart Diseases-associated-Venous Insufficiency', 'Venous Insufficiency-associated-Heart Diseases', 'Infectious Mononucleosis-associated-Venous Insufficiency', 'Venous Insufficiency-associated-Infectious Mononucleosis', 'Irritable Bowel Syndrome-associated-Venous Insufficiency', 'Venous Insufficiency-associated-Irritable Bowel Syndrome', 'Hip Fractures-attenuate-Fractures, Bone', 'Fatty Liver-observed-Fibrosis', 'Obesity-result-Weight Loss', 'Hyponatremia-correlated-Hip Fractures', 'Hyponatremia-reduce-Death', 'Diabetes Mellitus-apply-Metabolic Syndrome', 'Pneumonia, Aspiration-based-Deglutition Disorders', 'Neoplasms-use-Breast Neoplasms', 'Infections-related-Immunologic Deficiency Syndromes', 'Infections-associated-Immunologic Deficiency Syndromes', 'Immunologic Deficiency Syndromes-associated-Infections', 'Neoplasms-related-Immunologic Deficiency Syndromes', 'HIV Infections-related-Immunologic Deficiency Syndromes', 'HIV Infections-provide-Neoplasms', 'Neoplasms-prevent-HIV Infections', 'Neoplasms-caused-HIV Infections', 'HIV Infections-affect-Liver Diseases', 'Xerostomia-determine-Jaw Diseases', 'Erectile Dysfunction-linked-Cardiovascular Diseases', 'Death-coupled-Cardiovascular Diseases', 'Erectile Dysfunction-use-Cardiovascular Diseases', 'Erectile Dysfunction-evaluated-Cardiovascular Diseases', 'Chromosome Aberrations-referred-Aneuploidy', 'Lung Diseases, Obstructive-use-Death', 'Intervertebral Disc Degeneration-associated-Scoliosis', 'Scoliosis-associated-Intervertebral Disc Degeneration', 'Neoplasms-offer-Colorectal Neoplasms', 'Chromosome Aberrations-show-Neoplasms', 'Death-compare-Coma', 'Death-compare-Spinal Injuries', 'Death-compare-Fractures, Bone', 'Hemorrhage-arise-Arteriovenous Malformations', 'Wasting Syndrome-known-Progeria', 'Progeria-known-Genetic Diseases, Inborn', 'Cerebrovascular Disorders-quantify-Dementia', 'Alzheimer Disease-quantify-Dementia', 'Cardiac Output, Low-predict-Diabetes Mellitus', 'Cardiac Output, Low-predict-Neoplasms', 'Cardiac Output, Low-predict-Hypertension', 'Obesity-related-Venous Thromboembolism', 'Hypotension, Orthostatic-persist-Cardiovascular Diseases', 'Hypotension, Orthostatic-persist-Myocardial Infarction', 'Hypotension, Orthostatic-persist-Heart Failure', 'Hypotension, Orthostatic-persist-Stroke', 'Hypotension, Orthostatic-persist-Death', 'Fractures, Bone-calculated-Hip Fractures', 'Fractures, Bone-dichotomise-Hip Fractures', 'Hemorrhage-increasing-Constriction, Pathologic', 'Peptic Ulcer-increasing-Constriction, Pathologic', 'Hemorrhage-assessed-Thromboembolism', 'Hemorrhage-assessed-Atrial Fibrillation', 'Thromboembolism-assessed-Atrial Fibrillation', 'Parkinson Disease-occur-Movement Disorders', 'Hypotension, Orthostatic-reflect-Heart Failure', 'Parkinson Disease-reflect-Heart Failure', 'Atrophy-resemble-Parkinson Disease', 'Atrophy-resemble-Hypotension, Orthostatic', 'Anemia-associated-Leukoencephalopathies', 'Leukoencephalopathies-associated-Anemia', 'Heart Failure-compare-Coronary Artery Disease', 'Hearing Loss-induced-Wounds and Injuries', 'Delirium-associated-Endocrine System Diseases', 'Endocrine System Diseases-associated-Delirium', 'Chronic Disease-live-Cataract', 'Anorexia-considered-Epilepsy, Absence', 'Communicable Diseases-indicate-HIV Infections', 'Stroke-cause-Purpura, Thrombocytopenic, Idiopathic', 'Hematologic Neoplasms-highlight-Neoplasms', 'Eunuchism-associated-Erectile Dysfunction', 'Erectile Dysfunction-associated-Eunuchism', 'Eunuchism-associated-Osteoporosis', 'Osteoporosis-associated-Eunuchism', 'Chronic Disease-result-Eunuchism', 'Chronic Disease-come-Sexual Dysfunction, Physiological', 'Eunuchism-include-Sexual Dysfunction, Physiological', 'Cerebral Infarction-result-Alzheimer Disease', 'Cerebral Infarction-result-Coronary Artery Disease', 'Cerebral Infarction-result-Erectile Dysfunction', 'Respiratory Tract Infections-prevent-Cross Infection', 'Lens Diseases-collected-Cataract', 'Dyskeratosis Congenita-lead-Immunologic Deficiency Syndromes', 'Dyskeratosis Congenita-associated-Microcephaly', 'Microcephaly-associated-Dyskeratosis Congenita', 'Dyskeratosis Congenita-associated-Growth Disorders', 'Growth Disorders-associated-Dyskeratosis Congenita', 'Bone Marrow Failure Disorders-lead-Immunologic Deficiency Syndromes', 'Bone Marrow Failure Disorders-associated-Microcephaly', 'Microcephaly-associated-Bone Marrow Failure Disorders', 'Bone Marrow Failure Disorders-associated-Growth Disorders', 'Growth Disorders-associated-Bone Marrow Failure Disorders', 'Immunologic Deficiency Syndromes-associated-Microcephaly', 'Microcephaly-associated-Immunologic Deficiency Syndromes', 'Immunologic Deficiency Syndromes-associated-Growth Disorders', 'Growth Disorders-associated-Immunologic Deficiency Syndromes', 'Genetic Diseases, Inborn-characterized-Bone Marrow Failure Disorders', 'Sleep Wake Disorders-treat-Alzheimer Disease', 'Neoplasms-related-Neurodegenerative Diseases', 'Nervous System Diseases-related-Neurodegenerative Diseases', 'Death-collected-Metabolic Syndrome', 'Autoimmune Diseases-related-Neurodegenerative Diseases', 'Urinary Bladder, Overactive-cause-Central Nervous System Diseases', 'Meningitis-replaced-Pneumonia', 'Meningitis-caused-Pneumonia', 'Urinary Bladder, Overactive-range-Headache', 'Urinary Bladder, Overactive-range-Psychoses, Substance-Induced', 'Central Nervous System Diseases-range-Headache', 'Central Nervous System Diseases-range-Psychoses, Substance-Induced', 'Coronary Artery Disease-resemble-Werner Syndrome', 'Growth Disorders-resemble-Werner Syndrome', 'Death-follow-Endocrine System Diseases', 'Sepsis-include-Death', 'Vasculitis-associated-Polymyalgia Rheumatica', 'Polymyalgia Rheumatica-associated-Vasculitis', 'Vasculitis-make-Stroke', 'Polymyalgia Rheumatica-make-Stroke', 'Peripheral Arterial Disease-investigate-Arthritis, Rheumatoid', 'Cardiovascular Diseases-observed-Inflammation', 'Death-related-Hemorrhage', 'Heart Diseases-induced-Obesity', 'Breast Neoplasms-result-Bone Neoplasms', 'Multiple Myeloma-increase-Fractures, Bone', 'Arbovirus Infections-limit-Infections', 'Fibrosis-predispose-Atrial Fibrillation', 'Death-employ-Neoplasms', 'Weight Loss-reduce-Inflammation', 'Dyspnea-distribute-Hypotension', 'Cardiovascular Diseases-hospitalized-Pulmonary Infarction', 'Xeroderma Pigmentosum-defined-Skin Neoplasms', 'Xeroderma Pigmentosum-minimised-Neoplasms', 'Xeroderma Pigmentosum-distinguish-Urticaria', 'Xeroderma Pigmentosum-distinguish-Drug Eruptions', 'Xeroderma Pigmentosum-distinguish-Cockayne Syndrome', 'Xeroderma Pigmentosum-distinguish-Pigmentation Disorders', 'Xeroderma Pigmentosum-distinguish-LEOPARD Syndrome', 'Atrial Fibrillation-attributed-Arrhythmias, Cardiac', 'Stroke-attributed-Arrhythmias, Cardiac', 'Heterotaxy Syndrome-documented-Pericardial Effusion', 'Heterotaxy Syndrome-documented-Stroke', 'Thrombosis-found-Atrial Fibrillation', 'Heart Failure, Systolic-include-Hypotension', 'Heart Septal Defects, Atrial-identify-Heart Failure', 'Acute Coronary Syndrome-range-Angina, Unstable', 'Heart Septal Defects, Atrial-remain-Heart Failure', 'Coronary Artery Disease-range-Angina, Unstable', 'Death-assess-Hip Fractures', 'Metabolic Syndrome-increase-Acute Coronary Syndrome', 'Fibrosis-carry-Death', 'Osteoporosis-considered-Vascular Calcification', 'Chronic Kidney Disease-Mineral and Bone Disorder-protect-Vascular Calcification', 'Nystagmus, Pathologic-develop-Central Nervous System Diseases', 'Nystagmus, Pathologic-develop-Diabetes Mellitus', 'Nystagmus, Pathologic-develop-Hypertension', 'Nystagmus, Pathologic-develop-Cerebrovascular Disorders', 'Central Nervous System Diseases-paid-Cerebrovascular Disorders', 'Neoplasms-associated-Pulmonary Embolism', 'Pulmonary Embolism-associated-Neoplasms', 'Bacteremia-decrease-Central Nervous System Infections', 'Ankle Injuries-reduced-Pain', 'Cardiovascular Diseases-include-Progeria', 'Diabetes Mellitus-predominate-Inflammation', 'Hernia, Hiatal-undertaken-Motor Neuron Disease', 'Headache Disorders, Primary-characterized-Headache', 'Headache Disorders, Primary-characterized-Pain', 'Headache-related-Sleep Wake Disorders', 'Neoplasms-recruit-Digestive System Neoplasms', 'Musculoskeletal Diseases-control-Inflammation', 'Arthritis-enter-Inflammation', 'Diabetes Mellitus-increase-Vascular Calcification', 'Drug-Related Side Effects and Adverse Reactions-experience-Bone Marrow Diseases', 'Parkinsonian Disorders-reflected-Parkinson Disease', 'Hemorrhage-related-Aneurysm, Ruptured', 'Aortic Valve Stenosis-remain-Death', 'Diabetes Mellitus, Type 2-result-Acute Kidney Injury', 'Acute Kidney Injury-associated-Diabetes Mellitus, Type 2', 'Diabetes Mellitus, Type 2-associated-Acute Kidney Injury', 'Acute Kidney Injury-estimated-Diabetes Mellitus', 'Renal Insufficiency, Chronic-associated-Diabetes Mellitus, Type 2', 'Diabetes Mellitus, Type 2-associated-Renal Insufficiency, Chronic', 'Neoplasms-govern-Carcinogenesis', 'Psoriasis-diagnose-Onychomycosis', 'Psoriasis-differentiate-Onychomycosis', 'Asthma-associated-Dyspnea', 'Dyspnea-associated-Asthma', 'Asthma-associated-Headache Disorders, Secondary', 'Headache Disorders, Secondary-associated-Asthma', 'Obesity-related-Asthma', 'Retinal Degeneration-occurred-Alzheimer Disease', 'Asthma-increase-Obesity', 'Aneurysm-compare-Intracranial Aneurysm', 'Heart Diseases-portend-Renal Insufficiency', 'Memory Disorders-fight-Infections', 'Seizures-provide-Death', 'Renal Insufficiency, Chronic-known-Kidney Diseases', 'Renal Insufficiency, Chronic-known-Death', 'Renal Insufficiency, Chronic-known-Cardiovascular Diseases', 'Hypertension-known-Kidney Diseases', 'Hypertension-known-Death', 'Diabetes Mellitus-known-Kidney Diseases', 'Diabetes Mellitus-known-Cardiovascular Diseases', 'Hypertension-replicate-Memory Disorders', 'Neoplasms-involve-Ovarian Neoplasms', 'Death-overdose-Drug Overdose', 'Coronary Artery Disease-increase-Heart Failure', 'Death-occur-Coma', 'Atrial Fibrillation-related-Hemorrhage', 'Atrial Fibrillation-initiate-Hemorrhage', 'Intracranial Hemorrhages-associated-Death', 'Death-associated-Intracranial Hemorrhages', 'Stroke-provide-Intracranial Hemorrhages', 'Ventricular Remodeling-demonstrate-Hypertension', 'Cardiomyopathy, Dilated-demonstrate-Hypertension', 'Mastoiditis-augment-Cleft Lip', 'Pain-defined-Osteoarthritis', 'Hypotension-examine-Atrial Fibrillation', 'Genetic Diseases, Inborn-implicated-Neoplasms', 'Alzheimer Disease-published-Death', 'Death-use-Respiratory Tract Diseases', 'Ischemia-used-Dementia, Vascular', 'Hypertension-predispose-Heart Diseases', 'Arbovirus Infections-compared-Alzheimer Disease', 'Arbovirus Infections-compared-Neoplasms', 'Death-included-Heart Failure', 'Bacterial Infections-show-Death', 'Infections-suffer-Chronic Disease', 'Cataract-operate-Eye Diseases', 'Cataract-involved-Glucose Metabolism Disorders', 'Arrhythmias, Cardiac-compared-Heart Septal Defects, Atrial', 'Parkinson Disease-protected-Mitochondrial Diseases', 'Parkinson Disease-characterized-Retinal Degeneration', 'Dementia-exposed-Neurodegenerative Diseases', 'Dementia-exposed-Pain', 'Neurodegenerative Diseases-cause-Pain', 'Pain-recognized-Dementia', 'Dementia-accompanied-Pain', 'Pain-attenuated-Dementia', 'Dementia-made-Pain', 'Obesity-result-Hypertension', 'Hypertension-promote-Kidney Diseases', 'Musculoskeletal Diseases-contribute-Cardiovascular Diseases', 'Musculoskeletal Diseases-contribute-Back Pain', 'Musculoskeletal Diseases-contribute-Peripheral Vascular Diseases', 'Musculoskeletal Diseases-contribute-Stroke', 'Cartilage Diseases-recognised-Osteoarthritis', 'Bone Diseases-detected-Osteoarthritis', 'Osteochondritis-associated-Pain', 'Pain-associated-Osteochondritis', 'Anterior Cruciate Ligament Injuries-associated-Pain', 'Pain-associated-Anterior Cruciate Ligament Injuries', 'Pain-correlated-Osteochondritis', 'Lymphoma-cope-Drug-Related Side Effects and Adverse Reactions', 'Gout-include-Inflammation', 'Gout-control-Inflammation', 'Carcinogenesis-based-Neoplasms', 'Neoplasms-found-Ependymoma', 'Neoplasms-impacted-Seizures', 'Sleep Initiation and Maintenance Disorders-associate-Death', 'Death-associate-Sleep Initiation and Maintenance Disorders', 'Chagas Disease-associate-Death', 'Death-associate-Chagas Disease', 'Parkinson Disease-associated-Stroke', 'Stroke-associated-Parkinson Disease', 'Parkinson Disease-associated-Alcoholism', 'Alcoholism-associated-Parkinson Disease', 'Hyperlipidemias-associated-Parkinson Disease', 'Parkinson Disease-associated-Hyperlipidemias', 'Craniocerebral Trauma-encounter-Death', 'Hypotension-control-Hyperoxia', 'Parkinson Disease-associated-Malnutrition', 'Malnutrition-associated-Parkinson Disease', 'Malnutrition-associated-Periodontal Diseases', 'Periodontal Diseases-associated-Malnutrition', 'Hypotension-associated-Heart Failure', 'Heart Failure-associated-Hypotension', 'Heart Failure-develop-Hypotension', 'Hypertension-isolate-Hypotension', 'Back Injuries-sustain-Soft Tissue Injuries', 'Seizures-associated-Coronary Artery Disease', 'Coronary Artery Disease-associated-Seizures', 'Seizures-prevent-Death', 'Seizures-prevent-Cardiovascular Diseases', 'Atrial Fibrillation-reduce-Cardiac Output, High', 'Atrial Fibrillation-considered-Stroke', 'Heart Failure-follow-Heart Valve Diseases', 'Death-predict-Diabetes Mellitus, Type 2', 'Corneal Edema-occur-Mitochondrial Diseases', 'Infections-result-Stroke', 'Deglutition Disorders-result-Stroke', 'Gout-chronic-Pain', 'Gout-chronic-Musculoskeletal Diseases', 'Gout-develop-Hyperuricemia', 'Gout-develop-Hypertension', 'Gout-develop-Kidney Diseases', 'Gout-followed-Hyperuricemia', 'Inflammation-followed-Hyperuricemia', 'Muscle Weakness-predict-Death', 'Coronary Vasospasm-induce-Coronary Artery Disease', 'Spasm-induce-Coronary Artery Disease', 'Coronary Vasospasm-known-Coronary Artery Disease', 'Peptic Ulcer-account-Hemorrhage', 'Vomiting-include-Hemorrhage', 'Sarcopenia-recognized-Obesity', 'Alzheimer Disease-accompanied-Nerve Degeneration', 'Metabolic Diseases-contribute-Cardiovascular Diseases', 'Pancreatitis-predict-Pancreatic Neoplasms', 'Gallstones-predict-Pancreatic Neoplasms', 'Hepatitis C-predict-Pancreatic Neoplasms', 'Anemia-characterize-HIV Infections', 'Inflammation-related-Infections', 'Acute Kidney Injury-impact-Death', 'Acute Kidney Injury-define-Kidney Diseases', 'Hypoxia-appear-Sleep Deprivation', 'Hypoxia-appear-Sleepiness', 'Postoperative Cognitive Complications-understand-Dementia', 'Atrial Fibrillation-stem-Arrhythmias, Cardiac', 'Hematologic Neoplasms-include-Anemia', 'Hematologic Neoplasms-increase-Anemia', 'Hematologic Neoplasms-increase-Myelodysplastic Syndromes', 'Diabetes Mellitus-contract-Tetany', 'Cerebral Small Vessel Diseases-cause-Necrosis', 'Dehydration-associated-Chronic Disease', 'Chronic Disease-associated-Dehydration', 'Shock-defined-Death', 'Cardiovascular Diseases-translate-Alzheimer Disease', 'Tics-visited-Tooth Loss', 'Death-remain-Parkinson Disease', 'Osteoarthritis-provided-Metabolic Syndrome', 'Osteoarthritis-promote-Cardiovascular Diseases', 'Metabolic Syndrome-promote-Cardiovascular Diseases', 'Cardiovascular Diseases-provide-Diabetes Mellitus', 'Neoplasms-used-Stroke', 'Heart Failure-defined-Death', 'Heart Failure-defined-Myocardial Infarction', 'Neurodegenerative Diseases-increasing-Neoplasms', 'Neurodegenerative Diseases-increasing-Cardiovascular Diseases', 'Carcinoma, Verrucous-associated-Neoplasms', 'Neoplasms-associated-Carcinoma, Verrucous', 'Peritonitis, Tuberculous-differentiate-Peritoneal Neoplasms', 'Appendicitis-become-Death', 'Death-predicted-Syncope', 'Muscular Dystrophy, Duchenne-identify-Osteoporosis', 'Drug-Related Side Effects and Adverse Reactions-observe-Neutropenia', 'Brain Injury, Chronic-result-Ependymoma', 'Hypertension-managed-Renal Insufficiency, Chronic', 'Alzheimer Disease-caused-Memory Disorders', 'Seizures-generalize-Epileptic Syndromes', 'Periodontitis-characterized-Periodontal Attachment Loss', 'Anemia-diagnosed-Dementia', 'Dementia-admitted-Respiratory Tract Infections', 'Dementia-admitted-Urinary Tract Infections', 'Dementia-admitted-Craniocerebral Trauma', 'Hemochromatosis-derived-Drug-Related Side Effects and Adverse Reactions', 'Lung Neoplasms-diagnosed-Neoplasms', 'Osteoporotic Fractures-associated-Muscular Dystrophy, Duchenne', 'Muscular Dystrophy, Duchenne-associated-Osteoporotic Fractures', 'Anemia-cause-Malabsorption Syndromes', 'Nervous System Diseases-cause-Malabsorption Syndromes', 'Prostatic Intraepithelial Neoplasia-support-Prostatic Neoplasms', 'Death-incurred-Fractures, Bone', 'Death-incurred-Hip Fractures', 'Anemia-manage-Chronic Disease', 'Renal Insufficiency, Chronic-stand-Ataxia', 'Muscle Weakness-stand-Ataxia', 'Tremor-stand-Ataxia', 'Ataxia-stand-Myoclonus', 'Hypokalemia-associated-Hypotension', 'Hypotension-associated-Hypokalemia', 'Hypokalemia-associated-Glucose Intolerance', 'Glucose Intolerance-associated-Hypokalemia', 'Hypokalemia-prevent-Diabetes Mellitus', 'Hypotension-prevent-Diabetes Mellitus', 'Glucose Intolerance-prevent-Diabetes Mellitus', 'Osteoarthritis-predicted-Musculoskeletal Pain', 'Wounds and Injuries-assigned-Death', 'Wounds and Injuries-fall-Death', 'Death-predict-Frailty', 'Fractures, Bone-treated-Pain', 'Cerebral Small Vessel Diseases-present-Cerebral Infarction', 'Hematoma-begin-Hypertension', 'Cerebrovascular Disorders-related-Parkinsonian Disorders', 'Infarction-show-Arteriolosclerosis', 'Malformations of Cortical Development-associated-Parkinsonian Disorders', 'Parkinsonian Disorders-associated-Malformations of Cortical Development', 'Parkinsonian Disorders-account-Infarction', 'Infarction-related-Parkinsonian Disorders', 'Stroke-follow-Death', 'Chest Pain-seen-Myocardial Infarction', 'Heart Diseases-evolve-Arrhythmias, Cardiac', 'Heart Diseases-associated-Alzheimer Disease', 'Alzheimer Disease-associated-Heart Diseases', 'Inflammation-play-Pulmonary Disease, Chronic Obstructive', 'Inflammation-involved-Pulmonary Disease, Chronic Obstructive', 'Inflammation-contribute-Bronchitis', 'Inflammation-relate-Airway Obstruction', 'Inflammation-relate-Emphysema', 'Pulmonary Disease, Chronic Obstructive-related-Airway Obstruction', 'Pulmonary Disease, Chronic Obstructive-relate-Airway Obstruction', 'Asthma-relate-Airway Obstruction', 'Parkinson Disease-increase-Sleep Wake Disorders', 'Neoplasms-render-Heart Arrest', 'Sleep Wake Disorders-described-Parkinson Disease', 'REM Sleep Behavior Disorder-described-Parkinson Disease', 'REM Sleep Behavior Disorder-develop-Headache Disorders, Secondary', 'Olfaction Disorders-develop-Headache Disorders, Secondary', 'Headache Disorders, Secondary-develop-Synucleinopathies', 'REM Sleep Behavior Disorder-regard-Parkinson Disease', 'REM Sleep Behavior Disorder-exist-Parkinson Disease', 'REM Sleep Behavior Disorder-stop-Neurodegenerative Diseases', 'Alzheimer Disease-develop-Sialic Acid Storage Disease', 'Cerebral Hemorrhage-diagnosed-Cerebral Amyloid Angiopathy', 'Cerebral Amyloid Angiopathy-occur-Leukoencephalopathies', 'Colitis-share-Inflammatory Bowel Diseases', 'Inflammatory Bowel Diseases-associated-Central Cord Syndrome', 'Central Cord Syndrome-associated-Inflammatory Bowel Diseases', 'Dementia-suffer-Fatigue', 'Respiratory Tract Diseases-assess-Airway Obstruction', 'Diabetes Mellitus-impact-Breech Presentation', 'Peripheral Nervous System Diseases-classified-Diabetes Mellitus', 'Metabolic Syndrome-associated-Muscle Weakness', 'Muscle Weakness-associated-Metabolic Syndrome', 'Ulcer-associated-Hip Fractures', 'Hip Fractures-associated-Ulcer', 'Edema-show-Death', 'Delirium-examine-Death', 'Death-predisposed-Infections', 'Infections-noted-Bacteremia', 'Infections-noted-Death', 'Inflammation-result-Pain', 'Diffuse Axonal Injury-associated-Coma', 'Coma-associated-Diffuse Axonal Injury', 'Diffuse Axonal Injury-range-Coma', 'Diffuse Axonal Injury-associated-Death', 'Death-associated-Diffuse Axonal Injury', 'Infections-remove-Eyelid Diseases', 'Esophageal Motility Disorders-influenced-Gastroesophageal Reflux', 'Esophageal Motility Disorders-occur-Gastroesophageal Reflux', 'Ventricular Remodeling-contribute-Death', 'Cystic Fibrosis-characterized-Headache Disorders, Secondary', 'Signs and Symptoms, Digestive-determined-Cystic Fibrosis', 'Signs and Symptoms, Digestive-determined-Pneumonia', 'Signs and Symptoms, Digestive-determined-Respiratory Tract Infections', 'Cystic Fibrosis-determined-Pneumonia', 'Death-include-Shock', 'Inflammation-correspond-Pulmonary Disease, Chronic Obstructive', 'Genetic Diseases, Inborn-linked-Inflammation', 'Memory Disorders-screen-Dementia', 'Kidney Failure, Chronic-result-Diabetic Nephropathies', 'Death-increase-Respiratory Tract Infections', 'Drug-Related Side Effects and Adverse Reactions-consider-Inflammation', 'Drug-Related Side Effects and Adverse Reactions-consider-End Stage Liver Disease', 'Inflammation-consider-End Stage Liver Disease', 'Death-treat-Obesity', 'Breast Neoplasms, Male-contribute-Osteoporotic Fractures', 'Osteoporosis-include-Breast Neoplasms, Male', 'Fractures, Bone-include-Breast Neoplasms, Male', 'Vascular Calcification-reflect-Osteochondritis', 'Pituitary Diseases-suspected-Headache', 'Progeria-include-Atherosclerosis', 'Contracture-include-Aging, Premature', 'Aging, Premature-include-Atherosclerosis', 'Inflammation-related-Obesity', 'Inflammation-related-Atherosclerosis', 'Inflammation-related-Diabetes Mellitus', 'Cerebrovascular Disorders-include-Communicable Diseases', 'Diabetes Mellitus, Type 2-include-Communicable Diseases', 'Liver Diseases-include-Communicable Diseases', 'Asthma-include-Communicable Diseases', 'Myotonic Dystrophy-assessed-Aortic Valve Stenosis', 'Heart Failure-worsen-Heart Failure, Diastolic', 'Cardiovascular Diseases-account-Acute Coronary Syndrome', 'Death-account-Acute Coronary Syndrome', 'Acute Coronary Syndrome-account-Death', 'Microaneurysm-include-Retinal Diseases', 'Hemorrhage-include-Retinal Diseases', 'Retinal Diseases-associated-Aneurysm', 'Aneurysm-associated-Retinal Diseases', 'Retinal Diseases-associated-Stroke', 'Stroke-associated-Retinal Diseases', 'Retinal Diseases-associated-Coronary Artery Disease', 'Coronary Artery Disease-associated-Retinal Diseases', 'Retinal Diseases-considered-Diabetes Mellitus', 'Retinal Diseases-caused-Diabetes Mellitus', 'Retinal Diseases-considered-Hypertension', 'Retinal Diseases-caused-Hypertension', 'Aneurysm-found-Diabetes Mellitus', 'Aneurysm-found-Hypertension', 'Retinal Diseases-seen-Diabetes Mellitus', 'Retinal Diseases-seen-Hypertension', 'Infections-detected-Epstein-Barr Virus Infections', 'Cystitis-vary-Pyelonephritis', 'Headache Disorders, Secondary-measured-Pain', 'Death-registered-Liver Diseases', 'Liver Cirrhosis-reveal-Death', 'Liver Cirrhosis-underlie-Death', 'Liver Cirrhosis-reveal-Pneumonia', 'Liver Cirrhosis-underlie-Pneumonia', 'Liver Cirrhosis-found-Death', 'Liver Cirrhosis-found-Bacteremia', 'Liver Cirrhosis-reveal-Sepsis', 'Liver Cirrhosis-underlie-Sepsis', 'Liver Cirrhosis-reveal-Bacteremia', 'Liver Cirrhosis-underlie-Bacteremia', 'Psychoses, Substance-Induced-suppose-Dementia', 'Death-increased-Inflammation', 'Substance-Related Disorders-include-Pain', 'Acute Kidney Injury-heighten-Renal Insufficiency, Chronic', 'Osteoporotic Fractures-demonstrate-Kyphosis', 'Osteoporotic Fractures-demonstrate-Lipodystrophy, Familial Partial', 'Neurologic Manifestations-compared-Spinal Injuries', 'Neurologic Manifestations-compared-Death', 'Neurologic Manifestations-result-Death', 'Cough-find-Infections', 'Breast Neoplasms-develop-Heart Failure', 'Breast Neoplasms-experience-Cardiotoxicity', 'Hernia-contain-Intestinal Obstruction', 'Death-attributed-Intestinal Obstruction', 'Death-attributed-Infarction', 'Death-attributed-Hernia', 'Death-complicate-Coronary Artery Disease', 'Intestinal Obstruction-complicate-Coronary Artery Disease', 'Infarction-complicate-Coronary Artery Disease', 'Death, Sudden-reported-Hemorrhage', 'Hernia-complicate-Coronary Artery Disease', 'Aneurysm, False-include-Neoplasms', 'Obesity-associated-Kidney Diseases', 'Kidney Diseases-associated-Obesity', 'Sarcopenia-describe-Death', 'Arrhythmias, Cardiac-classified-Heart Diseases', 'Inflammation-shown-Atrial Fibrillation', 'Fibrosis-promote-Arrhythmias, Cardiac', 'Hepatitis C, Chronic-remain-Carcinoma, Hepatocellular', 'Ischemia-cause-Myocardial Infarction', 'Hypoxia-cause-Myocardial Infarction', 'Heart Failure-become-Death', 'Fractures, Bone-include-Death', 'Polyps-found-Neoplasms', 'Arthritis, Juvenile-followed-Arthritis', 'Osteosarcoma-associated-Osteoarthritis', 'Osteoarthritis-associated-Osteosarcoma', 'Pain-treat-Substance-Related Disorders', 'Hyperparathyroidism, Secondary-suffer-Bone Diseases', 'Multiple Chronic Conditions-suffer-Bone Diseases', 'Hyperparathyroidism-prevent-Hypocalcemia', 'Atherosclerosis-caused-Wounds and Injuries', 'Heart Failure-precede-Death', 'Arrhythmias, Cardiac-assess-Atrial Fibrillation', 'Arrhythmias, Cardiac-assess-Stroke', 'Arrhythmias, Cardiac-assess-Heart Failure', 'Gastroenteritis-cause-Typhoid Fever', 'Heart Diseases-confirm-Coronary Artery Disease', 'Hip Fractures-include-Inert Gas Narcosis', 'Sleep Wake Disorders-determine-Sleep Initiation and Maintenance Disorders', 'HIV Infections-related-Death', 'Death-develop-Delirium', 'Mitochondrial Diseases-classified-Obesity', 'Idiopathic Pulmonary Fibrosis-associated-Immunologic Deficiency Syndromes', 'Immunologic Deficiency Syndromes-associated-Idiopathic Pulmonary Fibrosis', 'Diabetic Angiopathies-base-Hypertension', 'Diabetes Mellitus-base-Hypertension', 'Reflex, Abnormal-show-Death', 'Breast Neoplasms-provide-Neoplasms', 'Glucose Intolerance-linked-Metabolic Syndrome', 'Metabolic Syndrome-linked-Glucose Metabolism Disorders', 'Gastrointestinal Hemorrhage-defined-Hemorrhage', 'Weight Loss-recognized-Malnutrition', 'Obesity-stand-Obesity, Abdominal', 'Liver Failure-associated-Thrombosis', 'Thrombosis-associated-Liver Failure', 'Liver Failure-associated-Hypothyroidism', 'Hypothyroidism-associated-Liver Failure', 'Liver Failure-associated-Osteoporosis', 'Osteoporosis-associated-Liver Failure', 'Liver Failure-associated-Hypogonadism', 'Hypogonadism-associated-Liver Failure', 'Coronary Artery Disease-increase-Obesity', 'Myocardial Infarction-assessed-Stroke', 'Stroke-compare-Hemorrhage', 'Stroke-used-Hemorrhage', 'Atrial Fibrillation-used-Hemorrhage', 'Death-occur-Sepsis', 'Death-occur-Infarction', 'Ovarian Diseases-associated-Coronary Artery Disease', 'Coronary Artery Disease-associated-Ovarian Diseases', 'Ovarian Diseases-associated-Osteoarthritis', 'Osteoarthritis-associated-Ovarian Diseases', 'Ovarian Diseases-associated-Osteoporosis', 'Osteoporosis-associated-Ovarian Diseases', 'Delirium-occur-Dementia', 'Delirium-impact-Neurodegenerative Diseases', 'Dementia-impact-Neurodegenerative Diseases', 'Dementia-suffer-Delirium', 'Infections-increase-Alzheimer Disease', 'Infections-accelerate-Dementia', 'Inflammation-foster-Chronic Disease', 'Delirium-range-Movement Disorders', 'Diabetes Mellitus-found-Graft Occlusion, Vascular', 'Diabetes Mellitus-found-Heart Failure', 'Infections-implicated-Death', "Bowen's Disease-characterized-Dental Plaque", 'Carcinoma, Squamous Cell-characterized-Dental Plaque', 'Cerebral Amyloid Angiopathy-emerging-Alzheimer Disease', 'Cerebral Amyloid Angiopathy-emerging-Brain Diseases', 'Hearing Loss-associated-Otitis', 'Otitis-associated-Hearing Loss', 'Hearing Loss-associated-Hearing Loss, Noise-Induced', 'Hearing Loss, Noise-Induced-associated-Hearing Loss', 'Uveitis-present-Panuveitis', 'Hyperkalemia-avoid-Heart Failure', 'Skin Diseases-lead-Pruritus', 'Hypotension-defined-Death', 'Neurodegenerative Diseases-lead-Pruritus', 'Hypotension-defined-Wounds and Injuries', 'Caliciviridae Infections-associated-Death', 'Death-associated-Caliciviridae Infections', 'Caliciviridae Infections-compare-Death', 'Anemia-associated-Hyponatremia', 'Hyponatremia-associated-Anemia', 'Fallopian Tube Diseases-associated-Hyponatremia', 'Hyponatremia-associated-Fallopian Tube Diseases', 'Renal Insufficiency, Chronic-become-Hypertension', 'Renal Insufficiency, Chronic-become-Diabetes Mellitus', 'Kidney Diseases-associated-Drug-Related Side Effects and Adverse Reactions', 'Drug-Related Side Effects and Adverse Reactions-associated-Kidney Diseases', 'Hepatitis C, Chronic-involve-Renal Insufficiency, Chronic', 'Hepatitis C, Chronic-impact-Death', 'Death-decrease-Seizures', 'Seizures-account-Death', 'Femoral Fractures-result-Death', 'Fractures, Bone-performed-Postpartum Hemorrhage', 'Gait Disorders, Neurologic-related-Ataxia', 'Gait Disorders, Neurologic-related-Spinal Cord Diseases', 'Gait Disorders, Neurologic-related-Stroke', 'Gait Disorders, Neurologic-related-Parkinson Disease, Secondary', 'Gait Disorders, Neurologic-stem-Carcinoma', 'Gait Disorders, Neurologic-address-Carcinoma', 'Drug-Related Side Effects and Adverse Reactions-result-Paralysis', 'Retinal Vein Occlusion-provoke-Vision Disorders', 'Macular Degeneration-create-Glaucoma', 'Infections-lead-Heart Failure', 'Retinal Diseases-ameliorate-Diabetes Mellitus', 'Death-underlie-Hepatitis, Viral, Human', 'Death-attributed-Liver Diseases', 'Death-examine-Immunologic Deficiency Syndromes', 'Death-examine-Acquired Immunodeficiency Syndrome', 'Death-contrast-Drug Overdose', 'Liver Diseases-attributed-Death', 'Liver Diseases-examine-Immunologic Deficiency Syndromes', 'Liver Diseases-examine-Acquired Immunodeficiency Syndrome', 'Liver Diseases-contrast-Drug Overdose', 'Drug-Related Side Effects and Adverse Reactions-given-Death', 'Osteoporosis-coexist-Chronic Disease', 'Obesity-prevent-Inflammation', 'Obesity-prevent-Periodontal Diseases', 'Periodontal Diseases-include-Inflammation', 'Leukoaraiosis-include-Cerebral Hemorrhage', 'Stroke-include-Cerebral Hemorrhage', 'Thromboembolism-confer-Intracranial Hemorrhages', 'Neoplasms-implicated-Heart Failure', 'Neoplasms-identify-Heart Failure', 'Atrial Fibrillation-suffer-Heart Failure', 'Atrial Fibrillation-suffer-Angina Pectoris', 'Urinary Bladder Neoplasms-detected-Hematuria', 'Neoplasms-detected-Hematuria', 'Atherosclerosis-result-Rupture', 'Atherosclerosis-result-Thrombosis', 'Atherosclerosis-result-Cerebrovascular Disorders', 'Atherosclerosis-provide-Cerebrovascular Disorders', 'Constipation-caused-Pelvic Floor Disorders', 'Death-documented-Cardiovascular Diseases', 'Nervous System Diseases-reduce-Skin Neoplasms', 'Inflammatory Bowel Diseases-distinguish-Colitis', 'Carpal Tunnel Syndrome-develop-Amyloidosis', 'Pituitary Neoplasms-diagnosed-Hemorrhage', 'Pituitary Neoplasms-diagnosed-Ischemia', 'Cerebral Amyloid Angiopathy-cited-Cerebral Hemorrhage', 'Cerebral Amyloid Angiopathy-develop-Hemorrhage', 'Cerebral Amyloid Angiopathy-develop-Neurodegenerative Diseases', 'Death-projected-Coronary Artery Disease', 'Mitral Valve Insufficiency-cause-Death', 'Diabetic Nephropathies-follow-Lupus Erythematosus, Systemic', 'Amyloidosis-follow-Lupus Erythematosus, Systemic', 'Tuberculosis, Spinal-produce-Spinal Diseases', 'Musculoskeletal Diseases-lead-Pelvic Pain', 'Musculoskeletal Diseases-lead-Respiratory Distress Syndrome', 'Musculoskeletal Diseases-lead-Paraplegia', 'Pneumonia, Aspiration-increased-Cough', 'Parkinson Disease-increased-Cough', 'Parkinson Disease-document-Cough', 'Breast Neoplasms-refer-Neoplasms', 'Cough-performed-Parkinson Disease', 'Thyroid Diseases-manifested-Hyperthyroidism', 'Leukoencephalopathies-benefit-Dementia', 'Metabolic Syndrome-include-Prostatic Hyperplasia', 'Atherosclerosis-include-Prostatic Hyperplasia', 'Sexual Dysfunction, Physiological-include-Metabolic Syndrome', 'Sexual Dysfunction, Physiological-include-Atherosclerosis', 'Weight Loss-involve-Sexual Dysfunction, Physiological', 'Weight Loss-involve-Prostatic Hyperplasia', 'Neurodegenerative Diseases-occur-Mitochondrial Diseases', 'Infections-occur-Cerebellar Diseases', 'Pneumonia, Pneumocystis-prevent-Pulmonary Disease, Chronic Obstructive', 'Pneumonia, Pneumocystis-associated-HIV Infections', 'HIV Infections-associated-Pneumonia, Pneumocystis', 'Death-undergo-Neoplasm Metastasis', 'Pneumonia, Pneumocystis-correlate-Pneumonia', 'Pneumonia, Pneumocystis-correlate-Pulmonary Disease, Chronic Obstructive', 'Infections-estimated-Coinfection', 'Coronary Artery Disease-treated-Death', 'Coronary Artery Disease-adjusted-Death', 'Arteriosclerosis Obliterans-include-Limb Deformities, Congenital', 'Drug-Related Side Effects and Adverse Reactions-inhibit-Neoplasms', 'Hypogonadism-contribute-Bone Diseases, Metabolic', 'Anemia-lead-Bone Resorption', 'Iron Metabolism Disorders-lead-Bone Resorption', 'Epilepsy, Tonic-Clonic-prevent-Fractures, Bone', 'Rotavirus Infections-compared-Respiratory Tract Diseases', 'Vision, Low-associated-Hearing Loss', 'Hearing Loss-associated-Vision, Low', 'Weight Loss-used-Malnutrition', 'Weight Loss-screen-Malnutrition', 'Hallux Valgus-compare-Metatarsus Varus', 'Muscular Atrophy-contribute-Death', 'Tauopathies-display-Dementia', 'Tauopathies-display-Alzheimer Disease', 'Neurodegenerative Diseases-develop-Inflammation', 'Neurodegenerative Diseases-develop-Ischemia', 'Neurodegenerative Diseases-develop-Drug-Related Side Effects and Adverse Reactions', 'Hip Fractures-assessed-Parkinson Disease, Secondary', 'Tauopathies-exemplified-Alzheimer Disease', 'Inflammation-include-Atherosclerosis', 'Neuroendocrine Tumors-considered-Appendiceal Neoplasms', 'Death-suffer-Dementia', 'Dementia-suffer-Nervous System Diseases', 'X-Linked Combined Immunodeficiency Diseases-include-Immunologic Deficiency Syndromes', 'Dementia-related-Death', 'Deglutition Disorders-induce-Pneumonia, Aspiration', 'Deglutition Disorders-associated-Substance-Related Disorders', 'Substance-Related Disorders-associated-Deglutition Disorders', 'Calcinosis-observed-Kidney Diseases', 'Osteoporosis-observed-Kidney Diseases', 'Renal Insufficiency, Chronic-characterized-Bone Diseases', 'Skin Neoplasms-arise-Neoplasms', 'Bone Diseases-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-Bone Diseases', 'Neuroblastoma-include-Neoplasms', 'Genetic Diseases, Inborn-lead-Neoplasms', 'Asthma-receive-Drug Hypersensitivity', 'Dehydration-cause-Radicular Cyst', 'Rupture-cause-Radicular Cyst', 'Multiple Organ Failure-found-Death', 'Multiple Organ Failure-found-Acute Kidney Injury', 'Retinal Degeneration-include-Osteoarthritis', 'Osteoarthritis-show-Calcinosis', 'Tibial Meniscus Injuries-appear-Osteoarthritis', 'Neurotoxicity Syndromes-related-Alzheimer Disease', 'Thrombosis-described-Congenital Abnormalities', 'Immunologic Deficiency Syndromes-present-Thrombosis', 'Pulmonary Embolism-occur-Congenital Abnormalities', 'Heart Failure-undergo-Death', 'Sarcopenia-operate-Hypertrophy', 'Calcinosis-associated-Fractures, Bone', 'Fractures, Bone-associated-Calcinosis', 'Sleep Wake Disorders-result-Gastrointestinal Diseases', 'Sleep Wake Disorders-result-Irritable Bowel Syndrome', 'Sleep Wake Disorders-result-Gastroesophageal Reflux', 'Sleep Wake Disorders-result-Peptic Ulcer', 'Pulmonary Disease, Chronic Obstructive-show-Hypoxia', 'Inflammation-influence-Ventricular Remodeling', 'Lymphopenia-reported-Autoimmune Diseases', 'Ocular Hypertension-prevent-Retinal Diseases', 'Atrophy-associated-Neoplasms', 'Neoplasms-associated-Atrophy', 'Drug Hypersensitivity-indicate-Asthma', 'Drug Hypersensitivity-indicate-Rhinitis', 'Drug Hypersensitivity-indicate-Death', 'Obesity-measured-Alzheimer Disease', 'Asthma-indicate-Death', 'Low Back Pain-considered-Intervertebral Disc Degeneration', 'Neck Pain-considered-Intervertebral Disc Degeneration', 'Fractures, Bone-help-Death', 'Fractures, Bone-improve-Death', 'Skin Diseases-grow-Pigmentation Disorders', 'Hypertension-develop-Hypotension, Orthostatic', 'Alcoholism-develop-Hypotension, Orthostatic', 'Diabetes Mellitus-become-Chronic Disease', 'Infections-applied-Glomerulonephritis', 'Diabetes Mellitus-reflect-Staphylococcal Infections', 'Anemia-include-Anemia, Iron-Deficiency', 'Anemia-include-Inflammation', 'Inflammation-link-Neoplasms', 'HIV Infections-accelerated-Pulmonary Disease, Chronic Obstructive', 'HIV Infections-include-Pulmonary Disease, Chronic Obstructive', 'HIV Infections-increase-Infections', 'Infections-include-Pulmonary Disease, Chronic Obstructive', 'HIV Infections-associated-Pulmonary Disease, Chronic Obstructive', 'Pulmonary Disease, Chronic Obstructive-associated-HIV Infections', 'Constriction, Pathologic-detect-Atherosclerosis', 'Critical Illness-identify-Fever', 'Gastrointestinal Diseases-associated-Constipation', 'Constipation-associated-Gastrointestinal Diseases', 'Scoliosis-cause-Neurologic Manifestations', 'Scoliosis-associated-Back Pain', 'Back Pain-associated-Scoliosis', 'Scoliosis-associated-Pain', 'Pain-associated-Scoliosis', 'Neurologic Manifestations-associated-Back Pain', 'Back Pain-associated-Neurologic Manifestations', 'Gastrointestinal Diseases-associated-Mucositis', 'Mucositis-associated-Gastrointestinal Diseases', 'Breast Neoplasms-use-Arteriosclerosis', 'Breast Neoplasms-use-Osteoporosis', 'Breast Neoplasms-include-Infections', 'Breast Neoplasms-include-Neoplasm Invasiveness', 'Breast Neoplasms-include-Carcinoma, Ductal', 'Breast Neoplasms-include-Liposarcoma', 'Inflammatory Bowel Diseases-divided-Crohn Disease', 'Inflammatory Bowel Diseases-divided-Colitis, Ulcerative', 'Ileal Diseases-associated-Colonic Neoplasms', 'Colonic Neoplasms-associated-Ileal Diseases', 'Colitis, Ulcerative-based-Colitis', 'Colitis-associated-Death', 'Death-associated-Colitis', 'Hypothyroidism-attributed-Asthenia', 'Hypothyroidism-attributed-Bradycardia', 'Hypothyroidism-attributed-Pleural Effusion', 'Hypothyroidism-attributed-Hyponatremia', 'Hypothyroidism-attributed-Respiratory Insufficiency', 'Hypothyroidism-attributed-Parkinson Disease', 'Hypothyroidism-attributed-Pulmonary Disease, Chronic Obstructive', 'Pleural Effusion-do-Bradycardia', 'Neurodegenerative Diseases-linked-Alzheimer Disease', 'Arthritis, Rheumatoid-associated-Carpal Tunnel Syndrome', 'Carpal Tunnel Syndrome-associated-Arthritis, Rheumatoid', 'Arthritis, Rheumatoid-found-Gout', 'Arthritis, Rheumatoid-found-Hypertension', 'Arthritis, Rheumatoid-found-Diabetes Mellitus', 'Arthritis, Rheumatoid-found-Obesity', 'Arthritis, Rheumatoid-found-Uremia', 'Arthritis, Rheumatoid-found-Acromegaly', 'Carpal Tunnel Syndrome-followed-Gout', 'Carpal Tunnel Syndrome-associated-Gout', 'Gout-associated-Carpal Tunnel Syndrome', 'Carpal Tunnel Syndrome-followed-Hypertension', 'Carpal Tunnel Syndrome-followed-Diabetes Mellitus', 'Carpal Tunnel Syndrome-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-Carpal Tunnel Syndrome', 'Carpal Tunnel Syndrome-followed-Obesity', 'Carpal Tunnel Syndrome-associated-Obesity', 'Obesity-associated-Carpal Tunnel Syndrome', 'Carpal Tunnel Syndrome-followed-Uremia', 'Carpal Tunnel Syndrome-associated-Uremia', 'Uremia-associated-Carpal Tunnel Syndrome', 'Carpal Tunnel Syndrome-followed-Acromegaly', 'Colorectal Neoplasms-describe-Neoplasms', 'Chronic Disease-increase-Chronic Pain', 'Cardiovascular Diseases-increase-Chronic Pain', 'Neoplasms-increase-Chronic Pain', 'Osteoporosis-increase-Chronic Pain', 'Obesity, Abdominal-associated-Arthritis', 'Arthritis-associated-Obesity, Abdominal', 'Obesity, Abdominal-generalise-Arthritis', 'Death-improve-Weight Loss', 'Osteoarthritis-define-Pain', 'Tooth Erosion-occur-Osteoarthritis', 'Death-suffer-Pneumonia', 'Brain Neoplasms-show-Small Cell Lung Carcinoma', 'Cough-diagnosed-Lung Neoplasms', 'Brain Neoplasms-diagnosed-Small Cell Lung Carcinoma', 'Anorexia-predispose-Weight Loss', 'Anorexia-cause-Death', 'Weight Loss-cause-Death', 'Anorexia-prevent-Weight Loss', 'Fractures, Bone-devastating-Death', 'Bone Neoplasms-associated-Immunologic Deficiency Syndromes', 'Immunologic Deficiency Syndromes-associated-Bone Neoplasms', 'Dental Caries-include-Mouth Diseases', 'Pneumonia-caused-Death', 'Skin Neoplasms-occur-Prostatic Neoplasms', 'Hemochromatosis-increase-Neoplasms', 'Hepatitis B-increase-Neoplasms', 'Endometriosis-recognized-Neoplasms', 'Endometriosis-increase-Neoplasms', 'Infections-result-Empyema, Subdural', 'Hematoma, Subdural-result-Empyema, Subdural', 'Carotid Artery Diseases-investigate-Atherosclerosis', 'Carotid Artery Diseases-confirm-Atherosclerosis', 'Stroke-account-Death', 'Diabetes Mellitus-cause-Microaneurysm', 'Diabetes Mellitus-cause-Hemorrhage', 'Ischemia-increase-Diabetes Mellitus', 'Chronic Disease-likened-Death', 'Pneumonia-make-Respiratory Insufficiency', 'Fistula-include-Peripheral Vascular Diseases', 'Cerebrovascular Disorders-constitute-Death', 'Heart Failure, Diastolic-distinguish-Heart Failure, Systolic', 'Ocular Motility Disorders-range-Anorexia', 'Venous Thrombosis-regarded-Atherosclerosis', 'Venous Thrombosis-regarded-Thromboembolism', 'Asthma-related-Pneumonia', 'Seizures-confirm-Sclerosis', 'Sclerosis-characterized-Gliosis', 'Sclerosis-distinguish-Death', 'Sclerosis-associated-Death', 'Death-associated-Sclerosis', 'Neoplasm Metastasis-correlate-Neoplasms', 'Neoplasms-promote-Head and Neck Neoplasms', 'Hemorrhage-present-Wounds and Injuries', 'Hemorrhage-present-Blood Coagulation Disorders, Inherited', 'Tuberculosis-range-Chemical and Drug Induced Liver Injury', 'Tuberculosis-range-Liver Failure', 'Fistula-receive-Unilateral Breast Neoplasms', 'Arbovirus Infections-protect-Severe Acute Respiratory Syndrome', 'Leg Injuries-associated-Death', 'Death-associated-Leg Injuries', 'Heart Failure-defined-Hypertrophy, Left Ventricular', 'Xeroderma Pigmentosum-named-Skin Neoplasms', 'Genetic Diseases, Inborn-cause-Cockayne Syndrome', 'Genetic Diseases, Inborn-cause-Trichothiodystrophy Syndromes', 'Nervous System Malformations-cause-Neoplasms', 'Nervous System Malformations-cause-Cockayne Syndrome', 'Nervous System Malformations-cause-Trichothiodystrophy Syndromes', 'Neoplasms-cause-Cockayne Syndrome', 'Neoplasms-cause-Trichothiodystrophy Syndromes', 'Chemical and Drug Induced Liver Injury-detect-Necrosis', 'Obesity-report-Fractures, Bone', 'Alzheimer Disease-give-Diffuse Neurofibrillary Tangles with Calcification', 'Memory Disorders-give-Diffuse Neurofibrillary Tangles with Calcification', 'Alzheimer Disease-characterised-Memory Disorders', 'Osteoarthritis-elevated-Obesity', 'Osteoarthritis-minimized-Osteoporosis', 'Obesity-minimized-Osteoporosis', 'Parkinson Disease-exhibit-Lewy Body Disease', 'Parkinson Disease-play-Neurodegenerative Diseases', 'Neurodegenerative Diseases-play-Sleep Initiation and Maintenance Disorders', 'Neurologic Manifestations-trigger-Nerve Degeneration', 'Primary Immunodeficiency Diseases-suffer-Liver Diseases', 'Stroke-report-Neoplasms', 'Immunologic Deficiency Syndromes-suffer-Liver Diseases', 'Diabetes Mellitus-suffer-Liver Diseases', 'Obesity-regarded-Atherosclerosis', 'Obesity-regarded-Coronary Artery Disease', 'Obesity-regarded-Myocardial Infarction', 'Obesity-regarded-Stroke', 'Diabetes Mellitus-sustain-Ankle Fractures', 'Diabetes Mellitus-sustain-Fractures, Bone', 'Diabetes Mellitus-sustain-Infections', 'Diabetes Mellitus-sustain-Sensation Disorders', 'Fractures, Bone-include-Ankle Fractures', 'Infections-include-Ankle Fractures', 'Sensation Disorders-include-Ankle Fractures', 'Sensation Disorders-include-Fractures, Bone', 'Diabetes Mellitus-treat-Ankle Fractures', 'Prostatic Neoplasms-classified-Oculocerebrorenal Syndrome', 'Prostatic Neoplasms-observed-Neoplasms', 'Fasciculation-associated-Fatigue', 'Fatigue-associated-Fasciculation', 'Acquired Immunodeficiency Syndrome-develop-Death', 'Neoplasms-screen-Bone Neoplasms', 'Breast Neoplasms-screen-Bone Neoplasms', 'Fractures, Bone-seen-Brain Injuries, Traumatic', 'Brain Injuries, Traumatic-seen-Fractures, Bone', 'Wounds and Injuries-result-Pain, Postoperative', 'Hypogonadism-lead-Bone Neoplasms', 'Hemostatic Disorders-result-Thrombosis', 'Osteoporosis-examine-Fractures, Bone', 'Acute Kidney Injury-diagnosed-Kidney Tubular Necrosis, Acute', 'Acute Kidney Injury-diagnosed-Kidney Diseases', 'Metabolic Diseases-accelerate-Muscular Atrophy', 'Chronic Disease-accelerate-Muscular Atrophy', 'Diabetes Mellitus, Type 2-accelerate-Muscular Atrophy', 'Cardiovascular Diseases-accelerate-Muscular Atrophy', 'Deglutition Disorders-associated-Neoplasms', 'Neoplasms-associated-Deglutition Disorders', 'Neoplasms-associated-Ulcer', 'Ulcer-associated-Neoplasms', 'Gingivitis-experience-Pain', 'Pneumonia-experience-Pain', 'Zoonoses-needed-Communicable Diseases', 'Infections-compare-Zoonoses', 'Death-related-Catheter-Related Infections', 'Sarcopenia-known-Death', 'Hypertension-coexist-Diabetes Mellitus', 'Hypertension-increase-Kidney Diseases', 'Neoplasms-mimic-Infections', 'Hip Dislocation, Congenital-crossed-Sarcoma', 'Neoplasms-mimic-Tuberculosis', 'Neoplasms-mimic-Adrenal Insufficiency', 'Hip Dislocation, Congenital-crossed-Giant Cell Tumors', 'Neoplasms-mimic-Fractures, Avulsion', 'Neoplasms-mimic-Fibrous Dysplasia of Bone', 'Neoplasms-mimic-Bone Cysts, Aneurysmal', 'Hypoalbuminemia-associated-Invasive Fungal Infections', 'Invasive Fungal Infections-associated-Hypoalbuminemia', 'Osteoporosis-induced-Fractures, Bone', 'Pneumococcal Infections-make-Neoplasm Invasiveness', 'Fever-caused-Gastroenteritis', 'Coronary Artery Disease-associated-Carpal Tunnel Syndrome', 'Carpal Tunnel Syndrome-associated-Coronary Artery Disease', 'Heart Valve Diseases-associated-Carpal Tunnel Syndrome', 'Carpal Tunnel Syndrome-associated-Heart Valve Diseases', 'Osteoarthritis-concur-Weight Loss', 'Osteoarthritis-concur-Obesity', 'Osteoarthritis-emphasize-Pain', 'Obesity-considered-Osteoarthritis', 'Obesity-manage-Osteoarthritis', 'Brain Injuries, Traumatic-prevent-Brain Injuries', 'Brain Diseases-differ-Dementia', 'Brain Diseases-differ-Alzheimer Disease', 'Cerebrovascular Disorders-peak-Alzheimer Disease', 'Sclerosis-peak-Alzheimer Disease', 'Brain Diseases-peak-Alzheimer Disease', 'Hypertrophy-occur-Urinary Bladder Neck Obstruction', 'Hypertrophy-caused-Prostatic Hyperplasia', 'Urinary Bladder Diseases-induced-Prostatic Hyperplasia', 'Hypertrophy-occur-Prostatic Hyperplasia', 'Urinary Bladder Neck Obstruction-caused-Prostatic Hyperplasia', 'Neoplasms-promote-Precancerous Conditions', 'Hernia, Hiatal-associated-Lung Diseases', 'Lung Diseases-associated-Hernia, Hiatal', 'Hernia, Hiatal-associated-Venous Thromboembolism', 'Venous Thromboembolism-associated-Hernia, Hiatal', 'Hernia, Hiatal-associated-Death', 'Death-associated-Hernia, Hiatal', 'Stroke-result-Carotid Stenosis', 'Status Epilepticus-observed-Alcoholic Intoxication', 'Status Epilepticus-observed-Epilepsy', 'Epilepsy-related-Alcoholic Intoxication', 'Asthma-affect-Chronic Disease', 'Genetic Diseases, Inborn-promote-Neoplasms', 'Neoplasms-estimate-Prostatic Neoplasms', 'Fibrosis-promote-Breast Neoplasms', 'Ossification of Posterior Longitudinal Ligament-use-Leukoencephalopathies', 'Hemorrhage-increased-Thromboembolism', 'Liver Diseases-included-Carcinogenesis', 'Neoplasms-view-Dementia', 'Neoplasms-view-Death', 'Dementia-view-Death', 'Erectile Dysfunction-include-Headache Disorders, Secondary', 'Death-decrease-Fractures, Bone', 'Osteoporotic Fractures-control-Dementia', 'Osteoporotic Fractures-use-Osteoporosis', 'Dementia-use-Osteoporosis', 'Diabetes Mellitus-favour-Drug Hypersensitivity', 'Heart Defects, Congenital-experienced-Thyroid Diseases', 'Heart Defects, Congenital-experienced-Epilepsy', 'Heart Defects, Congenital-experienced-Alzheimer Disease', 'Neoplasms-regarded-Lymphoma', 'Necrosis-observed-Death', 'Venous Thrombosis-predict-Carcinoma, Hepatocellular', 'Neoplasms-predict-Carcinoma, Hepatocellular', 'Neoplasms-deserve-Coagulation Protein Disorders', 'Diabetes Mellitus-deserve-Coagulation Protein Disorders', 'Cardiovascular Diseases-deserve-Coagulation Protein Disorders', 'Chorea-develop-Parkinson Disease, Secondary', 'Chorea-develop-Muscle Rigidity', 'Obesity-associated-Nerve Degeneration', 'Nerve Degeneration-associated-Obesity', 'Obesity-associated-Infertility', 'Infertility-associated-Obesity', 'Parasitemia-support-Inflammation', 'Fanconi Anemia-cause-Neoplasms', 'Fanconi Anemia-cause-Prostatic Neoplasms', 'Neoplasms-follow-Heart Arrest', 'Neoplasms-occur-Acquired Immunodeficiency Syndrome', 'Trauma, Nervous System-identify-Neurodegenerative Diseases', 'Stroke-identify-Neurodegenerative Diseases', 'Substance-Related Disorders-identify-Neurodegenerative Diseases', 'Overbite-associated-Edema', 'Edema-associated-Overbite', 'Non-alcoholic Fatty Liver Disease-defined-Chemical and Drug Induced Liver Injury', 'Non-alcoholic Fatty Liver Disease-defined-Liver Diseases', 'Fatty Liver-defined-Chemical and Drug Induced Liver Injury', 'Fatty Liver-defined-Liver Diseases', 'Fatty Liver-exclude-Non-alcoholic Fatty Liver Disease', 'Neoplasms-affected-Metabolism, Inborn Errors', 'Spondylosis-excluded-Osteoporosis', 'Bone Neoplasms-induce-Inflammation', 'Airway Obstruction-defined-Pulmonary Disease, Chronic Obstructive', 'Inflammation-induce-Obesity', 'Fractures, Bone-sustain-Osteonecrosis', 'Hematoma-require-Intracranial Hemorrhages', 'Renal Insufficiency-increase-Hemorrhage', 'Sepsis-increase-Hemorrhage', 'Hypertension-diagnose-Myasthenia Gravis', 'Hypertension-diagnose-Diplopia', 'Hypertension-diagnose-Respiratory Distress Syndrome', 'Hypertension-diagnose-Stupor', 'Myasthenia Gravis-presented-Diplopia', 'Myasthenia Gravis-diagnose-Respiratory Distress Syndrome', 'Diplopia-diagnose-Respiratory Distress Syndrome', 'Respiratory Distress Syndrome-diagnose-Stupor', 'Neoplasms-associated-Ovarian Neoplasms', 'Ovarian Neoplasms-associated-Neoplasms', 'Stargardt Disease-caused-Inflammation', 'Growth Disorders-develop-Neoplasms', 'Leukoencephalopathies-rated-Infarction', 'Atrophy-rated-Infarction', 'Hypertension-predict-Ischemia', 'Stroke-impaired-Vision Disorders', 'Hypertension-found-Diabetes Mellitus', 'Hypertension-found-Cardiovascular Diseases', 'Death-retained-Coronary Artery Disease', 'Fever-caused-Communicable Diseases', 'Fever-caused-Neoplasms', 'Fever-caused-Aneurysm', 'Drug-Related Side Effects and Adverse Reactions-characterize-Adrenal Insufficiency', 'Communicable Diseases-discontinued-Fever', 'Heart Failure-treat-Heart Diseases', 'Hypoglycemia-represent-Diabetes Mellitus, Type 2', 'Carcinoma, Squamous Cell-added-Lymphoma, AIDS-Related', 'Wounds and Injuries-cause-Smooth Muscle Tumor', 'Giant Cell Arteritis-preexist-Diabetes Mellitus', 'Diabetes Mellitus-followed-Optic Neuropathy, Ischemic', 'Diabetes Mellitus-develop-Optic Neuropathy, Ischemic', 'Diabetes Mellitus-associated-Optic Neuropathy, Ischemic', 'Optic Neuropathy, Ischemic-associated-Diabetes Mellitus', 'Alzheimer Disease-contribute-Neurotoxicity Syndromes', 'Death-study-Chronic Disease', 'Musculoskeletal Diseases-involve-Chronic Pain', 'Cataract-remain-Diabetes Mellitus', 'Adrenal Insufficiency-associate-Cataract', 'Cataract-associate-Adrenal Insufficiency', 'Cataract-associated-Adrenal Insufficiency', 'Adrenal Insufficiency-associated-Cataract', 'Adrenal Insufficiency-remain-Diabetes Mellitus', 'Cataract-combine-Adrenal Insufficiency', 'Atherosclerosis-minimize-Dyslipidemias', 'Respiratory Insufficiency-include-Death', 'Death-include-Pneumonia, Pneumocystis', 'Death-include-Pneumothorax', 'Death-accompany-Pneumothorax', 'Weight Loss-include-Pneumonia, Pneumocystis', 'Weight Loss-accompany-Pneumothorax', 'Pneumonia, Pneumocystis-accompany-Pneumothorax', 'Infections-occur-Fever', 'Infections-occur-Headache', 'Hemophilia A-contribute-Joint Diseases', 'Infections-occur-Conjunctivitis', 'Hemophilia A-contribute-Intra-Articular Fractures', 'Infections-occur-Pharyngeal Diseases', 'Infections-occur-Nausea', 'Joint Diseases-result-Intra-Articular Fractures', 'Hemophilia A-include-Blood Coagulation Disorders', 'Hemophilia A-associated-Blood Coagulation Disorders', 'Blood Coagulation Disorders-associated-Hemophilia A', 'Hemophilia A-referred-Joint Diseases', 'Blood Coagulation Disorders-referred-Joint Diseases', 'Constriction, Pathologic-affected-Coronary Artery Disease', 'Constriction, Pathologic-affected-Cerebral Small Vessel Diseases', 'Inflammation-result-Arthritis, Rheumatoid', 'Inflammation-result-Psoriasis', 'Dementia-treated-Pain', 'Disease Susceptibility-associated-Dementia', 'Dementia-associated-Disease Susceptibility', 'Dementia-develop-Dementia, Vascular', 'Neoplasms-categorize-Infections', 'Thrombophilia-assess-Hemostatic Disorders', 'Alzheimer Disease-remain-Death', 'Alzheimer Disease-reverse-Memory Disorders', 'Neoplasms-limit-Atherosclerosis', 'Coronary Artery Disease-limit-Atherosclerosis', 'Dementia-indicated-Psychomotor Agitation', 'Dementia-indicated-Psychoses, Substance-Induced', 'Coronary Artery Disease-reduce-Stroke', 'Dry Eye Syndromes-seen-Entropion', 'Pain-developed-Dementia', 'Memory Disorders-include-Delirium', 'Neurodegenerative Diseases-suggest-Intervertebral Disc Degeneration', 'Colorectal Neoplasms-caused-Osteoporosis', 'Kyphosis-caused-Osteoporosis', 'Tibial Meniscus Injuries-increase-Hypertension', 'Hypertension-increase-Thrombosis', 'Pneumococcal Infections-compare-Pneumonia', 'Pneumococcal Infections-obtained-Pneumonia', 'Hepatolenticular Degeneration-contribute-Parkinson Disease', 'Neoplasms-treated-Sarcoma', 'Epilepsy, Post-Traumatic-account-Epilepsy', 'Brain Injuries, Traumatic-associated-Epilepsy', 'Epilepsy-associated-Brain Injuries, Traumatic', 'Death-affect-Diabetes Mellitus', 'Hypertension-affect-Diabetes Mellitus', 'Stroke-affect-Diabetes Mellitus', 'Dementia-affect-Diabetes Mellitus', 'Coronary Artery Disease-affect-Diabetes Mellitus', 'Cardiovascular Diseases-followed-Infections', 'Hypoalbuminemia-proved-Death', 'Infections-occupy-Cardiovascular Diseases', 'Infections-occupy-Neoplasms', 'Death-occupy-Cardiovascular Diseases', 'Death-occupy-Neoplasms', 'Heart Failure-occupy-Cardiovascular Diseases', 'Heart Failure-occupy-Neoplasms', 'Vascular System Injuries-occur-Death', 'Vascular System Injuries-associated-Death', 'Death-associated-Vascular System Injuries', 'Metabolic Syndrome-increase-Hypertension', 'Respiratory Insufficiency-predict-Death', 'Osteoporosis-become-Dementia', 'Prostatic Hyperplasia-established-Drug-Related Side Effects and Adverse Reactions', 'Sarcopenia-affected-Cerebrovascular Disorders', 'Sarcopenia-affected-Osteoarthritis', 'Dementia-reported-Central Nervous System Vascular Malformations', 'Infarction-associated-Cerebral Amyloid Angiopathy', 'Cerebral Amyloid Angiopathy-associated-Infarction', 'Seizures-resemble-Epilepsy', 'Epilepsy-highlight-Cerebrovascular Disorders', 'Epilepsy-highlight-Neurodegenerative Diseases', 'Memory Disorders-influence-Headache Disorders, Secondary', 'Memory Disorders-associated-Deglutition Disorders', 'Deglutition Disorders-associated-Memory Disorders', 'Gastrointestinal Diseases-include-Agranulocytosis', 'Gastrointestinal Diseases-include-Diarrhea', 'Gastrointestinal Diseases-include-Nausea', 'Gastrointestinal Diseases-include-Vomiting', 'Neoplasms-thought-Diabetes Mellitus, Type 2', 'Neoplasms-thought-Cardiovascular Diseases', 'Hypoglycemia-avoided-Hyperglycemia', 'Parkinsonian Disorders-span-Neurodegenerative Diseases', 'Adrenoleukodystrophy-associated-Hearing Loss', 'Hearing Loss-associated-Adrenoleukodystrophy', 'Posterior Tibial Tendon Dysfunction-misdiagnosed-Osteoarthritis', 'Posterior Tibial Tendon Dysfunction-misdiagnosed-Obesity', 'Alzheimer Disease-develop-Meningoencephalitis', 'Wounds and Injuries-progress-Joint Diseases', 'Wounds and Injuries-progress-Osteoarthritis', 'Dementia-defined-Parkinson Disease', 'Fractures, Bone-considered-Osteoporotic Fractures', 'Oculocerebrorenal Syndrome-investigated-Osteoporosis', 'Chronic Disease-examine-Malnutrition', 'Infections-associated-Bronchiolitis', 'Bronchiolitis-associated-Infections', 'Death-suffer-Hernia, Obturator', 'Death-suffer-Coronary Artery Disease', 'Osteoporosis-suffer-Hernia, Obturator', 'Osteoporosis-suffer-Coronary Artery Disease', 'Dementia-arise-Cerebrovascular Disorders', 'Stroke-arise-Cerebrovascular Disorders', 'Stroke-uncovered-Cerebrovascular Disorders', 'Respiratory Insufficiency-provoke-Venous Thromboembolism', 'Brain Infarction-provoke-Venous Thromboembolism', 'Sarcopenia-include-Fractures, Bone', 'Sarcopenia-assess-Fractures, Bone', 'Communicable Diseases-provoke-Venous Thromboembolism', 'Coronary Artery Disease-provoke-Venous Thromboembolism', 'Muscular Diseases-associated-Chronic Disease', 'Chronic Disease-associated-Muscular Diseases', 'Heart Failure-provoke-Venous Thromboembolism', 'Heart Failure-exhibit-Sleep Apnea Syndromes', 'HIV Infections-persist-Fractures, Bone', 'Alcoholism-remain-HIV Infections', 'Alcoholism-associate-Fractures, Bone', 'Fractures, Bone-associate-Alcoholism', 'HIV Infections-associate-Fractures, Bone', 'Fractures, Bone-associate-HIV Infections', 'Death-exceed-Critical Illness', 'Critical Illness-exceed-Lung Diseases', 'Alzheimer Disease-present-Sleep Wake Disorders', 'Communicable Diseases-suspected-Fever', 'Brain Injuries, Traumatic-result-Atrophy', 'Atrophy-examine-Brain Injuries, Traumatic', 'Mitral Valve Insufficiency-referred-Heart Valve Diseases', 'Bone Diseases-mediated-Hyperphosphatemia', 'Hyperphosphatemia-associated-Immunologic Deficiency Syndromes', 'Immunologic Deficiency Syndromes-associated-Hyperphosphatemia', 'Sclerosis-mistaken-Alzheimer Disease', 'Ventricular Remodeling-underlie-Heart Diseases', 'Atrial Remodeling-demonstrate-Atrial Fibrillation', 'Death-include-Acute Coronary Syndrome', 'Death-known-Obesity', 'Obesity-reduce-Inflammation', 'Melanoma-use-Neoplasms', 'Hereditary Breast and Ovarian Cancer Syndrome-characterized-Neurologic Manifestations', 'Hereditary Breast and Ovarian Cancer Syndrome-defined-Neurologic Manifestations', 'Osteoporotic Fractures-focused-Seizures', 'Pain-include-Respiratory Insufficiency', 'Pain-include-Hypotension', 'Pain-include-Nausea', 'Pain-include-Vomiting', 'Pain-include-Pruritus', 'Heart Block-provide-Pain Insensitivity, Congenital', 'Heart Block-provide-Pain', 'Lung Neoplasms-explored-Carcinogenesis', 'Diabetes Mellitus-avoid-Obesity', 'Inflammation-induce-Heart Failure', 'Pressure Ulcer-followed-Infections', 'Hypoxia-implicated-Leukoencephalopathies', 'Hypoxia-develop-Leukoencephalopathies', 'Colonic Neoplasms-determine-Constipation', 'Peripheral Nervous System Diseases-include-Neurotoxicity Syndromes', 'Neurotoxicity Syndromes-include-Diabetes Mellitus', 'Autoimmune Diseases-include-Inflammation', 'Pulmonary Fibrosis-include-Inflammation', 'Kidney Diseases-suggest-Renal Insufficiency', 'Kidney Diseases-suggest-Diabetes Mellitus', 'Kidney Diseases-suggest-Acute Kidney Injury', 'Renal Insufficiency-develop-Headache Disorders, Secondary', 'Renal Insufficiency-develop-Pulmonary Edema', 'Venous Thromboembolism-guide-Kidney Diseases', 'Metabolic Syndrome-investigate-Hypogonadism', 'Aneurysm-linked-Hypertension', 'Obesity-conceal-Sarcopenia', 'Obesity-alleviated-Weight Loss', 'Death-extrapolate-Lung Neoplasms', 'Hemorrhage-describe-Lupus Erythematosus, Systemic', 'Malformations of Cortical Development-shown-Dyscalculia', 'Malformations of Cortical Development-shown-Language Disorders', 'Dementia-exclude-Central Nervous System Diseases', 'Dementia-model-Hearing Loss', 'Dementia-adjusted-Hypertension', 'Hearing Loss-adjusted-Diabetes Mellitus', 'Hearing Loss-adjusted-Hypertension', 'Pain-undergo-Fractures, Bone', 'Primary Ovarian Insufficiency-identified-Chromosome Aberrations', 'Seizures-begin-Epilepsy, Absence', 'Seizures-begin-Epilepsies, Myoclonic', 'Dementia-suffer-Cardiovascular Diseases', 'Epilepsy, Absence-begin-Epilepsy, Tonic-Clonic', 'Epilepsies, Myoclonic-begin-Epilepsy, Tonic-Clonic', 'Epilepsy-begin-Epilepsy, Tonic-Clonic', 'Drug-Related Side Effects and Adverse Reactions-represent-Leukemia, Myeloid, Acute', 'Hearing Disorders-associated-Drug Hypersensitivity', 'Drug Hypersensitivity-associated-Hearing Disorders', 'Hearing Disorders-associated-Epilepsy', 'Epilepsy-associated-Hearing Disorders', 'Diabetes Mellitus-associated-Drug Hypersensitivity', 'Drug Hypersensitivity-associated-Diabetes Mellitus', 'Hypertension-associated-Drug Hypersensitivity', 'Drug Hypersensitivity-associated-Hypertension', 'Hypertension-associated-Epilepsy', 'Epilepsy-associated-Hypertension', 'Peripheral Arterial Disease-related-Renal Insufficiency', 'Peripheral Arterial Disease-related-Neoplastic Syndromes, Hereditary', 'Peripheral Arterial Disease-play-Cerebrovascular Disorders', 'Osteoporosis-associated-Drug Hypersensitivity', 'Drug Hypersensitivity-associated-Osteoporosis', 'Osteoporosis-associated-Epilepsy', 'Epilepsy-associated-Osteoporosis', 'Renal Insufficiency-play-Cerebrovascular Disorders', 'Neoplastic Syndromes, Hereditary-play-Cerebrovascular Disorders', 'Wounds and Injuries-precede-Spinal Cord Diseases', 'Neurologic Manifestations-avoided-Hypotension', 'Neoplasms-detect-Venous Thromboembolism', 'Leukemia, Lymphoid-diagnosed-Neoplasms', 'Muscular Diseases-implicated-Muscle Weakness', 'Tinnitus-associated-Craniocerebral Trauma', 'Craniocerebral Trauma-associated-Tinnitus', 'Tinnitus-associated-Otitis', 'Otitis-associated-Tinnitus', 'Tinnitus-associated-Arthritis', 'Arthritis-associated-Tinnitus', 'Osteogenesis Imperfecta-include-Craniofacial Abnormalities', 'Osteogenesis Imperfecta-include-Cleft Palate', 'Osteogenesis Imperfecta-include-Mastocytosis, Systemic', 'Wounds and Injuries-determine-Death', 'Neurologic Manifestations-assessed-Stroke', 'Memory Disorders-associated-Tremor', 'Tremor-associated-Memory Disorders', 'Memory Disorders-associated-Essential Tremor', 'Essential Tremor-associated-Memory Disorders', 'Dementia-associated-Essential Tremor', 'Essential Tremor-associated-Dementia', 'Essential Tremor-cases-Tremor', 'Metabolic Syndrome-impose-Atrial Fibrillation', 'Metabolic Syndrome-impose-Hypertension', 'Atrial Fibrillation-impose-Hypertension', 'Metabolic Syndrome-predict-Atrial Fibrillation', 'Death-followed-Cardiac Output, Low', 'Death-produce-Cardiac Output, Low', 'Fractures, Bone-treat-Osteoporotic Fractures', 'Spinocerebellar Ataxias-compare-Atrophy', 'Esophageal Neoplasms-associated-Hernia, Hiatal', 'Hernia, Hiatal-associated-Esophageal Neoplasms', 'Esophageal Neoplasms-associated-Ulcer', 'Ulcer-associated-Esophageal Neoplasms', 'Esophageal Neoplasms-associated-Hypertension', 'Hypertension-associated-Esophageal Neoplasms', 'Amyotrophic Lateral Sclerosis-head-Neurodegenerative Diseases', 'Lung, Hyperlucent-lead-Respiratory Tract Infections', 'Fibrosis-caused-Respiratory Tract Infections', 'Lung, Hyperlucent-diagnosed-Respiratory Tract Infections', 'Pneumonia-isolate-Bacteremia', 'Meningitis-isolate-Bacteremia', 'Botulism-characterized-Muscle Hypotonia', 'Fractures, Bone-fall-Pain', 'Death-found-Communicable Diseases', 'Delirium-mislabeled-Dementia', 'Death-show-Prostatic Neoplasms', 'Cardiovascular Diseases-experience-Thrombosis', 'Pain-decrease-Postoperative Cognitive Complications', 'Diverticulitis-affected-Diverticular Diseases', 'Dementia-estimated-Coma', 'Sleepiness-associated-Sleep Disorders, Circadian Rhythm', 'Sleep Disorders, Circadian Rhythm-associated-Sleepiness', 'Supranuclear Palsy, Progressive-include-Dementia', 'Amyotrophic Lateral Sclerosis-include-Dementia', 'Hypertension-increase-Leukoencephalopathies', 'Leukoencephalopathies-decrease-Hypertension', 'Seizures-differ-Epilepsy', 'Heredodegenerative Disorders, Nervous System-include-Chronic Disease', 'Metabolic Syndrome-associated-Heart Diseases', 'Heart Diseases-associated-Metabolic Syndrome', 'Hyperglycemia-promote-Microvascular Angina', 'Obesity-conclude-Coronary Artery Disease', 'Hypertension-conclude-Coronary Artery Disease', 'Hypercholesterolemia-conclude-Coronary Artery Disease', 'Fibrosis-increase-Kidney Diseases', 'Muscular Diseases-accelerate-Muscular Dystrophies', 'Rothmund-Thomson Syndrome-characterized-Growth Disorders', 'Dementia-attributed-Aneurysm', 'Dementia-attributed-Alzheimer Disease', 'Alzheimer Disease-attributed-Aneurysm', 'Aneurysm, Ruptured-induce-Coronary Artery Disease', 'Cardiovascular Diseases-increase-Thrombosis', 'Tachycardia, Supraventricular-shorten-Drug Resistant Epilepsy', 'Tachycardia, Supraventricular-shorten-Atrial Remodeling', 'Atrial Fibrillation-shorten-Drug Resistant Epilepsy', 'Atrial Fibrillation-shorten-Atrial Remodeling', 'Heart Diseases-include-Fibrosis', 'Hypertrophy-include-Fibrosis', 'Heart Arrest-implicated-Neoplasms', 'Skin Diseases-address-Musculoskeletal Diseases', 'Headache-associated-Brain Infarction', 'Brain Infarction-associated-Headache', 'Parkinson Disease-compare-Alzheimer Disease', 'Parkinson Disease-decline-Alzheimer Disease', 'Dementia-decline-Alzheimer Disease', 'Death-cause-Fractures, Bone', 'Chest Pain-made-Pain', 'Meningeal Neoplasms-followed-Glioma', 'Anemia-diagnosed-Malnutrition', 'Graft vs Host Disease-result-Death', 'Dementia-query-Seizures', 'Intracranial Hemorrhages-include-Hemophilia A', 'Hemophilia A-face-Cardiovascular Diseases', 'Carcinoma, Hepatocellular-increasing-Hemophilia A', 'Carcinoma, Hepatocellular-increasing-Infections', 'End Stage Liver Disease-increasing-Hemophilia A', 'End Stage Liver Disease-increasing-Infections', 'Hemophilia A-increasing-Infections', 'Hemophilia A-increasing-HIV Infections', 'Neoplasms-involved-Heart Arrest', 'Fibromuscular Dysplasia-considered-Ischemia', 'Fibromuscular Dysplasia-considered-Stroke', 'Fibromuscular Dysplasia-considered-Hypertension', 'Alzheimer Disease-worsen-Diabetes Mellitus', 'Alzheimer Disease-worsen-Cerebrovascular Disorders', 'Diabetes Mellitus-worsen-Cerebrovascular Disorders', 'Cerebrovascular Disorders-defined-Metabolic Syndrome', 'Cerebrovascular Disorders-defined-Diabetes Mellitus', 'Diabetes Mellitus-cause-Infertility, Female', 'Neoplasms-found-Laryngeal Neoplasms', 'Headache Disorders, Secondary-predict-Menorrhagia', 'Obesity-apply-Cerebral Hemorrhage', 'Kidney Failure, Chronic-compensate-Aortic Diseases', 'Idiopathic Pulmonary Fibrosis-include-Sleep Wake Disorders', 'Idiopathic Pulmonary Fibrosis-include-Pulmonary Arterial Hypertension', 'Idiopathic Pulmonary Fibrosis-include-Coronary Artery Disease', 'Adenomatous Polyposis Coli-occur-Abdominal Pain', 'Adenomatous Polyposis Coli-occur-Fatigue', 'Myocardial Infarction-require-Infections', 'Adenomatous Polyposis Coli-present-Lymphoma, Mantle-Cell', 'Myocardial Infarction-require-Death', 'Pulmonary Embolism-require-Infections', 'Pulmonary Embolism-require-Death', 'Lymphoma, Mantle-Cell-include-Intestinal Polyposis', 'Central Nervous System Diseases-associated-Tuberculosis', 'Tuberculosis-associated-Central Nervous System Diseases', 'Tuberculosis-capture-Death', 'HIV Infections-associated-Tuberculosis', 'Tuberculosis-associated-HIV Infections', 'Infections-tend-Diabetes Mellitus', 'Infections-tend-Dyslipidemias', 'Osteoarthritis-viewed-Neurodegenerative Diseases', 'Osteoarthritis-viewed-Heart Failure', 'Dementia-fulfil-Delirium', 'Kidney Diseases-present-Diabetes Mellitus', 'Myocardial Infarction-related-Death', 'Myocardial Infarction-undergo-Death', 'Earache-progress-Osteomyelitis', 'Earache-progress-Diabetes Mellitus', 'Osteomyelitis-progress-Diabetes Mellitus', 'Osteomyelitis-based-Otitis', 'Ischemia-treat-Heart Diseases', 'Gallstones-cause-Intestinal Atresia', 'Nervous System Diseases-caused-Tetany', 'Aneurysm-appear-Dementia', 'Aneurysm-seem-Chronic Disease', 'Aneurysm-occur-Retinal Diseases', 'Chronic Disease-occur-Retinal Diseases', 'Lymphoproliferative Disorders-included-Neoplasms', 'Diabetes Mellitus-involved-Dementia, Vascular', 'Sexual Dysfunction, Physiological-characterized-Kidney Diseases', 'Fractures, Bone-promote-Osteogenesis Imperfecta', 'Xeroderma Pigmentosum-slow-Progeria', 'Death-associated-Genetic Diseases, Inborn', 'Genetic Diseases, Inborn-associated-Death', 'Diabetes Mellitus-do-Learning Disabilities', 'Death-do-Learning Disabilities', 'Infections-proven-Death', 'Neoplasms-required-Seizures', 'Drug Overdose-bolster-Death', 'Multiple Organ Failure-increase-Death', 'Metabolic Diseases-promote-Neurodegenerative Diseases', 'Diabetes Mellitus-exert-Inflammation', 'Osteoarthritis-characterized-Death', 'Rheumatic Diseases-characterized-Death', 'Mitochondrial Diseases-affect-Inflammation', 'Mitochondrial Diseases-affect-Calcinosis', 'Memory Disorders-characterize-Alzheimer Disease', 'Alzheimer Disease-effect-Sleep Initiation and Maintenance Disorders', 'Hyponatremia-include-Inflammation', 'Kidney Diseases-contribute-Death', 'Anemia, Sickle Cell-contribute-Death', 'Fever-associated-Dehydration', 'Dehydration-associated-Fever', 'Diabetes Mellitus-result-Glucose Metabolism Disorders', 'Hereditary Breast and Ovarian Cancer Syndrome-follow-Myocardial Infarction', 'Myocardial Infarction-associated-Hereditary Breast and Ovarian Cancer Syndrome', 'Hereditary Breast and Ovarian Cancer Syndrome-associated-Myocardial Infarction', 'Myocardial Infarction-develop-Heart Failure', 'Cough-characterized-Pharyngeal Diseases', 'Atherosclerosis-predispose-Thrombosis', 'Neurodegenerative Diseases-generated-Agnosia', 'Ocular Hypertension-implanted-Cataract', 'Stomach Neoplasms-reviewed-Neoplasms', 'Erectile Dysfunction-prescribed-Heart Failure', 'Erectile Dysfunction-prescribed-Hypertension', 'Erectile Dysfunction-related-Diabetes Mellitus', 'Erectile Dysfunction-related-Hypertension', 'Erectile Dysfunction-related-Atherosclerosis', 'Neoplasms-correlate-Amenorrhea', 'Metabolic Syndrome-determine-Hypertension', 'Neoplasms-include-Cutaneous Fistula', 'Nocturia-investigate-Death', 'Sleep Wake Disorders-include-Nocturia', 'Sleep Wake Disorders-include-Death', 'Osteoporosis-suffering-Spinal Diseases', 'Hypertension-lead-Aneurysm', 'Hypertension-reduce-Chronic Disease', 'Kidney Diseases-reduce-Chronic Disease', 'Obesity-reduce-Chronic Disease', 'Diabetes Mellitus-reduce-Chronic Disease', 'Neoplasms-reduce-Chronic Disease', 'Neurodegenerative Diseases-characterised-Ataxia Telangiectasia', 'Stroke-double-Dementia', 'Stroke-indicated-Dementia, Vascular', 'Cerebrovascular Disorders-mixed-Alzheimer Disease', 'Stroke-indicated-Alzheimer Disease', 'Stroke-indicated-Cerebrovascular Disorders', 'Meningeal Neoplasms-account-Neoplasms', 'Nervous System Diseases-appear-Neoplasms', 'Pain, Postoperative-evaluate-Pain', 'Hypertension-follow-Infections', 'Infections-associated-Heart Failure', 'Heart Failure-associated-Infections', 'Dementia-diagnosed-Dementia, Vascular', 'Drug-Related Side Effects and Adverse Reactions-reduced-Bone Marrow Diseases', 'Xeroderma Pigmentosum-characterized-Neoplasms', 'Atherosclerosis-fail-Aneurysm', 'Atherosclerosis-remain-Death', 'Pain Insensitivity, Congenital-defined-Pain', 'Pain Insensitivity, Congenital-defined-Hypesthesia', 'Pancreatitis-involve-Fibrosis', 'Xeroderma Pigmentosum-predispose-Skin Neoplasms', 'Diabetes Mellitus-lead-Alzheimer Disease', 'Endometrial Neoplasms-report-Hemorrhage', 'Death-seen-Obesity', 'Sarcoma-represent-Liposarcoma', 'Pruritus-lead-Infections', 'Mycoses-isolated-Psoriasis', 'Mycoses-associate-Psoriasis', 'Psoriasis-associate-Mycoses', 'Mycoses-isolated-Diabetes Mellitus', 'Mycoses-associate-Diabetes Mellitus', 'Diabetes Mellitus-associate-Mycoses', 'Hypothalamic Neoplasms-cause-Cushing Syndrome', 'Sleep Deprivation-complicate-Pruritus', 'Neoplasms-influence-Carcinogenesis', 'Breast Neoplasms-shaped-Neoplasms', 'Carcinoma, Non-Small-Cell Lung-demonstrate-Drug-Related Side Effects and Adverse Reactions', 'Drug-Related Side Effects and Adverse Reactions-discussed-Breast Neoplasms', 'Metabolic Syndrome-increase-Colonic Neoplasms', 'Metabolic Syndrome-elevate-Colonic Neoplasms', 'Arthritis, Rheumatoid-diagnosed-Lung Diseases, Interstitial', 'Alcoholism-include-Cardiovascular Diseases', 'Hepatitis E-prevent-Cardiovascular Diseases', 'Hepatitis E-control-Cardiovascular Diseases', 'Atherosclerosis-estimated-Cardiovascular Diseases', 'Atherosclerosis-use-Diabetes Mellitus', 'Cardiovascular Diseases-estimated-Diabetes Mellitus', 'Cardiovascular Diseases-increased-Atherosclerosis', 'Dementia, Vascular-reduce-Cerebrovascular Disorders', 'Dementia, Vascular-target-Stroke', 'Gastritis-promote-Gastroesophageal Reflux', 'Muscular Diseases-result-Wounds and Injuries', 'Gastritis-induce-Stomach Neoplasms', 'Sleep Apnea Syndromes-increase-Death', 'Sleep Apnea Syndromes-increase-Hypertension', 'Primary Immunodeficiency Diseases-associated-Neoplasms', 'Neoplasms-associated-Primary Immunodeficiency Diseases', 'Primary Immunodeficiency Diseases-increase-Neoplasms', 'Meningoencephalitis-lead-Drug-Related Side Effects and Adverse Reactions', 'Alzheimer Disease-lead-Drug-Related Side Effects and Adverse Reactions', 'Pain-improve-Rotator Cuff Tear Arthropathy', 'Neurodegenerative Diseases-include-Genetic Diseases, Inborn', 'Huntington Disease-include-Genetic Diseases, Inborn', 'HIV Infections-contribute-Hypothalamic Diseases', 'HIV Infections-result-Hypothalamic Neoplasms', 'Tooth Loss-report-Pain', 'Hemophilia A-associated-Autoimmune Diseases', 'Autoimmune Diseases-associated-Hemophilia A', 'Hemophilia A-associated-Neoplasms', 'Neoplasms-associated-Hemophilia A', 'Hemophilia A-associated-Infections', 'Infections-associated-Hemophilia A', 'Diabetes Mellitus-follow-Stroke', 'Pulmonary Edema-associated-Death', 'Death-associated-Pulmonary Edema', 'Osteoporosis-happen-Joint Diseases', 'Osteoporosis-result-Osteoarthritis', 'Joint Diseases-result-Osteoarthritis', 'Hypotension-recognized-Shock, Hemorrhagic', 'Death-result-Shock, Hemorrhagic', 'Death-increase-Shock, Hemorrhagic', 'Wounds and Injuries-considered-Hypotension', 'Coinfection-cause-Spinal Cord Injuries', 'Paraplegia-cause-Spinal Cord Injuries', 'Neoplasms-cause-Spinal Cord Injuries', 'Purpura, Thrombocytopenic, Idiopathic-treat-Cerebral Hemorrhage', 'Nephrotic Syndrome-followed-Kidney Failure, Chronic', 'Kidney Diseases-classified-Communicable Diseases', 'Atrophy-correlated-Aneurysm', 'Atrophy-correlated-Leukoencephalopathies', 'Kidney Diseases-predominate-Hypertension', 'Dementia-related-Aneurysm', 'Dementia-related-Atrophy', 'Atrophy-related-Aneurysm', 'Kidney Diseases-impact-Death', 'Kidney Diseases-use-Renal Insufficiency, Chronic', 'Diabetes Mellitus-take-Death', 'Aneurysm-related-Death', 'Aneurysm-take-Death', 'Alzheimer Disease-characterized-Sarcopenia', 'Hypertension-cause-Atrial Fibrillation', 'Heart Failure-cause-Atrial Fibrillation', 'Coronary Artery Disease-cause-Atrial Fibrillation', 'Seizures-alleviate-Neoplasms', 'Neoplasms-support-Seizures', 'Fractures, Bone-lead-Infections', 'Pneumococcal Infections-followed-Sleep Wake Disorders', 'Pneumococcal Infections-followed-Urinary Incontinence', 'Infections-appear-Pancreatic Neoplasms', 'Metabolic Syndrome-impair-Glucose Intolerance', 'Metabolic Syndrome-associated-Drug Hypersensitivity', 'Drug Hypersensitivity-associated-Metabolic Syndrome', 'Obesity-impair-Glucose Intolerance', 'Obesity-increase-Pancreatic Neoplasms', 'Glucose Intolerance-increase-Diabetes Mellitus', 'Glucose Intolerance-associated-Drug Hypersensitivity', 'Drug Hypersensitivity-associated-Glucose Intolerance', 'Glucose Intolerance-associated-Pancreatic Neoplasms', 'Pancreatic Neoplasms-associated-Glucose Intolerance', 'Diabetes Mellitus-increase-Pancreatic Neoplasms', 'Renal Insufficiency, Chronic-reduce-Inflammation', 'Drug Hypersensitivity-associated-Pancreatic Neoplasms', 'Pancreatic Neoplasms-associated-Drug Hypersensitivity', 'Chronic Disease-exhibit-Fibrosis', 'Fatty Liver-reduce-Inflammation', 'Heart Failure-reduce-Inflammation', 'Sclerosis-reduce-Inflammation', 'Inflammation-discussed-Sarcopenia', 'Alzheimer Disease-predict-Hip Fractures', 'Alzheimer Disease-experience-Hip Fractures', 'Alzheimer Disease-compare-Death', 'Neoplasms-range-Carcinoma, Papillary', 'Necrosis-invade-Osteogenesis Imperfecta', 'Death-play-Infections', 'Infections-play-Death', 'Dementia-investigate-Inflammation', 'Constriction, Pathologic-performed-Ischemia', 'Ischemia-performed-Death', 'Pain-associate-Hallux Valgus', 'Hallux Valgus-associate-Pain', 'Pain-remain-Hallux Valgus', 'Pain-associated-Hallux Valgus', 'Hallux Valgus-associated-Pain', 'Drug-Related Side Effects and Adverse Reactions-contribute-Neurodegenerative Diseases', 'Infections-focus-Inflammation', 'Infections-focus-Granulomatous Disease, Chronic', 'Tachycardia-lead-Syncope', 'Arrhythmias, Cardiac-questioned-Death', 'Inflammation-compared-Hip Fractures', 'Colitis-induce-Inflammation', 'Adenoma-treated-Adenocarcinoma', 'Hypertension-identify-Hypertension, Renovascular', 'Xerostomia-associated-Heredodegenerative Disorders, Nervous System', 'Heredodegenerative Disorders, Nervous System-associated-Xerostomia', 'Alzheimer Disease-associated-Learning Disabilities', 'Learning Disabilities-associated-Alzheimer Disease', 'Sleep Apnea Syndromes-involved-Glucose Metabolism Disorders', 'Apnea-incorporated-Diabetes Mellitus', 'Apnea-incorporated-Sleep Apnea Syndromes', 'Sleep Apnea Syndromes-incorporated-Diabetes Mellitus', 'Vertigo-treat-Nystagmus, Pathologic', 'Neoplasms-make-Anemia', 'Anemia-cause-Thrombosis', 'Anemia-include-Hypothyroidism', 'Neoplasms-cause-Thrombosis', 'Anemia-include-Sarcopenia', 'Fibrosis-seen-Myocarditis', 'Cardiomyopathies-characterized-Isolated Noncompaction of the Ventricular Myocardium', 'Fibrosis-seen-Inflammation', 'Fibrosis-seen-Ischemia', 'Neoplasms-stabilize-Death', 'Death-vary-Hip Fractures', 'Death-seem-Fractures, Bone', 'Hip Fractures-seem-Fractures, Bone', 'Hip Fractures-contribute-Postoperative Complications', 'Hip Fractures-contribute-Pneumonia', 'Hip Fractures-contribute-Pulmonary Embolism', 'Hip Fractures-contribute-Death', 'Lung Diseases-include-Infections', 'Lung Diseases-include-Heart Arrest', 'Lung Diseases-include-Hypoalbuminemia', 'Lung Diseases-include-Kidney Diseases', 'Venous Thrombosis-evaluated-Death', 'Pulmonary Embolism-evaluated-Death', 'Confusion-evaluated-Death', 'Death-improve-Hip Fractures', 'Renal Insufficiency, Chronic-profile-Death', 'Hemorrhage-attributed-Hemophilia A', 'Carcinoma, Squamous Cell-act-Neoplasms', 'Diabetes Mellitus-differ-Communicable Diseases', 'Neoplasms-differ-Communicable Diseases', 'Infections-differ-Communicable Diseases', 'Kidney Diseases-progress-Kidney Failure, Chronic', 'Diabetes Mellitus-predict-Kidney Failure, Chronic', 'Communicable Diseases-occur-Respiratory Tract Infections', 'Adenocarcinoma-predict-Kidney Failure, Chronic', 'Fibrosis-predict-Kidney Failure, Chronic', 'Memory Disorders-treat-Heredodegenerative Disorders, Nervous System', 'Memory Disorders-associated-Heredodegenerative Disorders, Nervous System', 'Heredodegenerative Disorders, Nervous System-associated-Memory Disorders', 'Gout-tolerate-Sleep Initiation and Maintenance Disorders', 'Sleep Initiation and Maintenance Disorders-categorized-Gout', 'Cataract-result-Vision, Low', 'Xerostomia-related-Ageusia', 'Xerostomia-diminish-Ageusia', 'Psychomotor Agitation-followed-Memory Disorders', 'Acute Coronary Syndrome-associated-Death', 'Death-associated-Acute Coronary Syndrome', 'Pain-quantified-Osteoarthritis, Knee', 'Inflammation-associated-Adenocarcinoma', 'Adenocarcinoma-associated-Inflammation', 'Celiac Disease-associated-Carcinoma, Small Cell', 'Carcinoma, Small Cell-associated-Celiac Disease', 'Celiac Disease-link-Carcinoma, Small Cell', 'Celiac Disease-considered-Adenocarcinoma', 'Celiac Disease-display-Neoplasms', 'Carcinoma, Small Cell-indicate-Carcinogenesis', 'Adenocarcinoma-display-Neoplasms', 'Celiac Disease-link-Carcinogenesis', 'Somatosensory Disorders-include-Bone Diseases, Metabolic', 'Somatosensory Disorders-preserve-Osteogenesis Imperfecta', 'Bone Diseases, Metabolic-preserve-Osteogenesis Imperfecta', 'Blindness-involve-Inflammation', 'Death-adjusted-Arthritis', 'Pain-adjusted-Arthritis', 'Atrophy-include-Eyelid Diseases', 'Fractures, Bone-underlie-Osteoporosis', 'Death-found-Endocarditis', 'Polycystic Kidney Diseases-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-Polycystic Kidney Diseases', 'Mastocytosis, Systemic-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-Mastocytosis, Systemic', 'Cardiovascular Diseases-seen-Polycystic Kidney Diseases', 'Hemorrhage-show-Hemosiderosis', 'Hemorrhage-show-Cerebral Hemorrhage', 'Metabolic Syndrome-carry-Death', 'Parkinson Disease-appear-Genetic Diseases, Inborn', 'Muscular Diseases-explain-Pulmonary Disease, Chronic Obstructive', 'Brain Diseases-contribute-Alzheimer Disease', 'Glucose Intolerance-include-Brain Diseases', 'Diabetes Mellitus, Type 1-develop-Diabetes Mellitus', 'Diabetes Mellitus, Type 1-connected-Autoimmune Diseases', 'Diabetes Mellitus, Type 1-associate-Autoimmune Diseases', 'Autoimmune Diseases-associate-Diabetes Mellitus, Type 1', 'Diabetes Mellitus-connected-Autoimmune Diseases', 'Obesity-compare-Quadriplegia', 'Heart Failure-result-Heart Diseases', 'Hodgkin Disease-include-Leukemia, Lymphocytic, Chronic, B-Cell', 'Leukemia, Lymphocytic, Chronic, B-Cell-stand-Neoplasms', 'Sleep Apnea, Obstructive-result-Pain', 'Lymphocytosis-appear-Leukemia, Lymphocytic, Chronic, B-Cell', 'Leukemia, Lymphocytic, Chronic, B-Cell-lack-Lymphoma', 'Leukemia, Lymphocytic, Chronic, B-Cell-define-Neoplasms', 'Myocardial Infarction-mobilized-Heart Diseases', 'Leukemia, Lymphocytic, Chronic, B-Cell-associated-Genetic Predisposition to Disease', 'Genetic Predisposition to Disease-associated-Leukemia, Lymphocytic, Chronic, B-Cell', 'Leukemia, Lymphocytic, Chronic, B-Cell-generate-Genetic Predisposition to Disease', 'Diabetes Mellitus-translate-Kidney Failure, Chronic', 'Lipodystrophy-fulfil-Marfan Syndrome', 'Hypertension-remain-Coronary Artery Disease', 'Hypertension-remain-Heart Failure', 'Heart Failure-analysed-Chronic Disease', 'Hypertension-detected-Heart Failure', 'Arrhythmias, Cardiac-detected-Heart Failure', 'Obesity-detected-Heart Failure', 'Diabetes Mellitus-detected-Heart Failure', 'Chronic Disease-detected-Heart Failure', 'Vertigo-suffer-Ischemia', 'Osteoporotic Fractures-experience-Fractures, Bone', 'Diabetes Mellitus, Type 2-associated-Eunuchism', 'Eunuchism-associated-Diabetes Mellitus, Type 2', 'Wounds and Injuries-increase-Infections', 'Wounds and Injuries-increase-Urinary Bladder Diseases', 'Neoplasms-range-Cardiovascular Diseases', 'Death-reduce-Autoimmune Diseases', 'Neoplasms-reduce-Autoimmune Diseases', 'Critical Illness-include-Inflammation', 'Death, Sudden, Cardiac-become-Cardiomyopathy, Hypertrophic', 'Death, Sudden, Cardiac-prevent-Cardiomyopathy, Hypertrophic', 'Death, Sudden, Cardiac-prevent-Hypertrophy, Left Ventricular', 'Death, Sudden, Cardiac-prevent-Hypotension', 'Death, Sudden, Cardiac-prevent-Ischemia', 'Cardiomyopathy, Hypertrophic-prevent-Hypertrophy, Left Ventricular', 'Cardiomyopathy, Hypertrophic-prevent-Hypotension', 'Cardiomyopathy, Hypertrophic-prevent-Ischemia', 'Osteoarthritis-range-Obesity', 'Bone Neoplasms-associated-Inflammatory Bowel Diseases', 'Inflammatory Bowel Diseases-associated-Bone Neoplasms', 'Inflammatory Bowel Diseases-correlate-Osteoporosis', 'Atrophy-stress-Alzheimer Disease', 'Inflammatory Bowel Diseases-used-Bone Diseases', 'Neoplasms-included-Adenoma', 'Adenoma, Oxyphilic-included-Adenoma', 'Thyroid Neoplasms-identify-Neoplasms', 'Neoplasms-reclassified-Thyroid Neoplasms', 'Glioblastoma-identified-Glioma', 'Cataract-affect-Vision Disorders', 'Invasive Pulmonary Aspergillosis-described-Neutropenia', 'Invasive Pulmonary Aspergillosis-described-Graft vs Host Disease', 'Opportunistic Infections-described-Neutropenia', 'Opportunistic Infections-described-Graft vs Host Disease', 'Neoplasms-treat-Sleep Initiation and Maintenance Disorders', 'Neurologic Manifestations-identified-Stroke', 'Subarachnoid Hemorrhage-identified-Stroke', 'Subarachnoid Hemorrhage-diagnosed-Headache', 'Subarachnoid Hemorrhage-reflect-Cerebral Amyloid Angiopathy', 'Pancreatitis-develop-Diabetes Mellitus, Type 1', 'Tularemia-adapted-Communicable Diseases', 'Atrioventricular Block-associated-Sinoatrial Block', 'Sinoatrial Block-associated-Atrioventricular Block', 'Renal Insufficiency, Chronic-associated-Sinoatrial Block', 'Sinoatrial Block-associated-Renal Insufficiency, Chronic', 'Cerebral Amyloid Angiopathy-cause-Infarction', 'Cerebral Amyloid Angiopathy-cause-Cerebral Hemorrhage', 'Cerebral Amyloid Angiopathy-cause-Leukoencephalopathies', 'Cerebral Amyloid Angiopathy-cause-Aneurysm', 'Cerebral Amyloid Angiopathy-contribute-Dementia', 'Cerebral Amyloid Angiopathy-based-Cerebrovascular Disorders', 'Cerebral Amyloid Angiopathy-remain-Neurodegenerative Diseases', 'Respiratory Insufficiency-complicate-Lung Injury', 'Lung Diseases, Interstitial-include-Respiratory Insufficiency', 'Drug Hypersensitivity-recognized-Inflammation', 'Chest Pain-include-Respiratory Insufficiency', 'Asthma-recognized-Inflammation', 'Pulmonary Disease, Chronic Obstructive-influence-Heart Failure', 'Tuberculosis-appear-Death', 'Diabetes Mellitus, Type 2-compared-Diabetes Mellitus', 'Cough-reported-Pneumonia, Aspiration', 'Cough-play-Pneumonia', 'Cough-shown-Drug Hypersensitivity', 'Cough-involve-Pneumonia, Aspiration', 'Muscular Dystrophies-observe-Cachexia', 'Muscular Dystrophies-observe-Muscular Atrophy', 'Muscular Dystrophies-observe-Neoplasms', 'Pneumonia, Aspiration-prevent-Cough', 'Muscular Dystrophies-observe-Heart Diseases', 'Muscular Dystrophies-observe-Pulmonary Disease, Chronic Obstructive', 'Muscular Dystrophies-affect-Muscular Diseases', 'Cachexia-cause-Muscular Atrophy', 'Muscular Atrophy-cause-Neoplasms', 'Muscular Atrophy-cause-Heart Diseases', 'Muscular Atrophy-cause-Pulmonary Disease, Chronic Obstructive', 'Muscular Dystrophies-halt-Muscular Diseases', 'Muscular Dystrophies-halt-Muscular Atrophy', 'Diabetes Mellitus-screen-Hearing Loss', 'Hypertension-increase-Dementia, Vascular', 'Aortic Aneurysm, Abdominal-remain-Death', 'Obesity-report-Arthritis', 'Arthritis-implement-Obesity', 'Heart Failure-show-Death', 'Stroke-collect-Cerebral Infarction', 'Osteoporosis-identify-Immunologic Deficiency Syndromes', 'Immunologic Deficiency Syndromes-identify-Bone Neoplasms', 'Bone Neoplasms-tied-Immunologic Deficiency Syndromes', 'Melanoma-vascularize-Neoplasms', 'Metabolic Syndrome-associated-Pain', 'Pain-associated-Metabolic Syndrome', 'Chronic Pain-use-Pain', 'Obesity, Abdominal-associated-Pain', 'Pain-associated-Obesity, Abdominal', 'Wounds and Injuries-protect-Pain', 'Death-examined-Parkinson Disease', 'Respiratory Tract Infections-exacerbate-Asthma', 'Neurodegenerative Diseases-accompany-Nerve Degeneration', 'Ventricular Dysfunction-include-Cardiomyopathy, Dilated', 'Ventricular Dysfunction-expected-Cardiomyopathy, Dilated', 'Ventricular Dysfunction-include-Aortic Valve Insufficiency', 'Ventricular Dysfunction-expected-Aortic Valve Insufficiency', 'Ventricular Dysfunction-include-Mitral Valve Insufficiency', 'Ventricular Dysfunction-expected-Mitral Valve Insufficiency', 'Anemia-cause-Hemorrhage', 'Death-rated-Malnutrition', 'Hypertension-identify-Death', 'Parkinson Disease-characterized-Spinocerebellar Ataxias', 'Xerostomia-recognized-Stomatognathic Diseases', 'Vision Disorders-correlate-Diabetes Mellitus', 'Hyperpigmentation-associated-Adrenal Insufficiency', 'Adrenal Insufficiency-associated-Hyperpigmentation', 'Craniocerebral Trauma-suffer-Wounds and Injuries', 'Retinal Neovascularization-lead-Vision Disorders', 'Fasciculation-lead-Fractures, Bone', 'Dementia-obtain-Death', 'Infarction-coexist-Alzheimer Disease', 'Multiple Myeloma-account-Neoplasms', 'Paraproteinemias-account-Neoplasms', 'Multiple Myeloma-included-Renal Insufficiency', 'Cardio-Renal Syndrome-prevent-Death, Sudden, Cardiac', 'Cardio-Renal Syndrome-prevent-Arrhythmias, Cardiac', 'Hypothermia-predict-Death', 'Inflammation-involved-Coronary Artery Disease', 'Inflammation-involved-Death', 'Pain-report-Fractures, Open', 'Death-associated-Jaundice', 'Jaundice-associated-Death', 'Hypoxia-coincide-Hyperglycemia', 'Hyperglycemia-characterized-Hyperlipidemias', 'Hyperglycemia-related-Diabetes Mellitus', 'Alzheimer Disease-linked-Memory Disorders', 'Anophthalmos-occur-Wounds and Injuries', 'Craniocerebral Trauma-associated-Vision Disorders', 'Vision Disorders-associated-Craniocerebral Trauma', 'Polyps-associated-Colorectal Neoplasms', 'Colorectal Neoplasms-associated-Polyps', 'Hypertension-receive-Diabetes Mellitus', 'Angiodysplasia-account-Ulcer', 'Parkinson Disease-use-Neurodegenerative Diseases', 'Drug-Related Side Effects and Adverse Reactions-induce-Glioma', 'Thromboembolism-lead-Stroke', 'Stroke-co-exist-Alzheimer Disease', 'Atrophy-progress-Alzheimer Disease', 'Basal Ganglia Cerebrovascular Disease-associated-Cerebral Hemorrhage', 'Cerebral Hemorrhage-associated-Basal Ganglia Cerebrovascular Disease', 'Cerebral Hemorrhage-associated-Dementia', 'Dementia-associated-Cerebral Hemorrhage', 'Cerebral Hemorrhage-increase-Atrophy', 'Dementia-increase-Atrophy', 'Lung Diseases-increase-HIV Infections', 'Aneurysm-constitute-Stroke', 'Cerebral Small Vessel Diseases-separated-Aneurysm', 'Aneurysm-include-Genetic Diseases, Inborn', 'Aneurysm-include-Brain Diseases', 'Aneurysm-include-Susac Syndrome', 'Genetic Diseases, Inborn-include-Brain Diseases', 'Genetic Diseases, Inborn-include-Susac Syndrome', 'Aneurysm-cause-Stroke', 'Aneurysm-cause-Leukoencephalopathies', 'Aneurysm-cause-Dementia, Vascular', 'Vision Disorders-subdivided-Heredodegenerative Disorders, Nervous System', 'Vision Disorders-term-Heredodegenerative Disorders, Nervous System', 'Arbovirus Infections-include-Respiratory Tract Diseases', 'Arbovirus Infections-induce-Respiratory Tract Diseases', 'Arbovirus Infections-include-Death', 'Respiratory Tract Diseases-induce-Death', 'Renal Insufficiency, Chronic-undergo-Hyperuricemia', 'Memory Disorders-occur-Urinary Incontinence', 'Gallstones-admitted-Intestinal Obstruction', 'Gallstones-suspected-Intestinal Obstruction', 'Gallstones-admitted-Cholelithiasis', 'Gallstones-suspected-Cholelithiasis', 'Myocardial Infarction-demonstrate-Death', 'Infections-range-Otitis', 'Pneumonia-range-Infections', 'Alzheimer Disease-protect-Neurofibrosarcoma', 'Dementia-taken-Memory Disorders', 'Pain-encountered-Infertility, Female', 'Epilepsy-used-Neuralgia', 'Hypothyroidism-progress-Thyroid Diseases', 'Mitochondrial Diseases-involve-Neurodegenerative Diseases', 'Huntington Disease-thought-Neurodegenerative Diseases', 'Mitochondrial Diseases-highlight-Alzheimer Disease', 'Stenosis, Pulmonary Artery-include-Cardiomyopathy, Hypertrophic', 'Neurologic Manifestations-presented-Headache', 'Neurologic Manifestations-presented-Nausea', 'Neurologic Manifestations-presented-Vomiting', 'Cerebrovascular Disorders-implicate-Neoplasms', 'Arrhythmias, Cardiac-cause-Coronary Artery Disease', 'Arrhythmias, Cardiac-cause-Hypertension', 'Arrhythmias, Cardiac-cause-Heart Failure', 'Progeria-cause-Heart Arrest', 'Alzheimer Disease-get-Dementia', 'Inflammation-initiate-Arrhythmias, Cardiac', 'Neurologic Manifestations-underlie-Chronobiology Disorders', 'Inflammation-initiate-Atrial Fibrillation', 'Hypothalamic Diseases-found-Alzheimer Disease', 'Muscular Diseases-contribute-Sleep Apnea, Obstructive', 'Fibrosis-initiate-Arrhythmias, Cardiac', 'Fibrosis-initiate-Atrial Fibrillation', 'Neurologic Manifestations-underlie-Alzheimer Disease', 'Diabetes Mellitus-provoke-Onychomycosis', 'Vision Disorders-tend-Psychomotor Disorders', 'Glomerulonephritis-collapse-Kidney Diseases', 'Dementia-characterized-Urinary Incontinence', 'Immunologic Deficiency Syndromes-associated-Endocrine System Diseases', 'Endocrine System Diseases-associated-Immunologic Deficiency Syndromes', 'Atrophy-suggest-Dementia, Vascular', 'Ventricular Dysfunction, Left-provide-Heart Failure, Diastolic', 'Dementia-detected-Death', 'Osteoporosis-fall-Cardiac Output, Low', 'Osteoporosis-fall-Hypotension, Orthostatic', 'Fractures, Bone-documented-Crohn Disease', 'Inflammation-associated-Crohn Disease', 'Crohn Disease-associated-Inflammation', 'Inflammation-predispose-Osteoporosis', 'Crohn Disease-predispose-Osteoporosis', 'Crohn Disease-increase-Fractures, Bone', 'Crohn Disease-associated-Fractures, Bone', 'Fractures, Bone-associated-Crohn Disease', 'Aortic Aneurysm, Abdominal-follow-Wounds and Injuries', 'Bone Neoplasms-put-Fractures, Bone', 'Neurodegenerative Diseases-cause-Parkinson Disease', 'Neurotoxicity Syndromes-investigate-Drug-Related Side Effects and Adverse Reactions', 'Osteoporosis-initiate-Hip Fractures', 'Osteoporosis-institute-Hip Fractures', 'Osteoporosis-start-Fractures, Bone', 'Mitochondrial Diseases-observed-Neoplasms', 'Migraine Disorders-suffer-Migraine with Aura', 'Mitochondrial Diseases-induce-Neoplasms', 'Obesity-drop-Dementia', 'Obesity-result-Dementia', 'Fractures, Bone-compared-Hip Fractures', 'Fractures, Bone-compared-Femoral Neck Fractures', 'Intracranial Hemorrhages-compared-Stroke', 'Renal Insufficiency, Chronic-review-Kidney Diseases', 'Intracranial Hemorrhages-treated-Stroke', 'Cerebral Infarction-increased-Atrial Fibrillation', 'Immune System Diseases-manifest-Neoplasms', 'Inflammation-involved-Metabolic Syndrome', 'Metabolic Syndrome-examine-Death', 'Metabolic Syndrome-manage-Dyslipidemias', 'Kidney Diseases-base-Proteinuria', 'Renal Insufficiency, Chronic-regarded-Aneurysm', 'Renal Insufficiency, Chronic-regarded-Kidney Failure, Chronic', 'Aneurysm-change-Kidney Failure, Chronic', 'Sleep Apnea, Obstructive-related-Blood Coagulation Disorders', 'Hypoxia-decrease-Sleep Apnea, Obstructive', 'Diabetes Mellitus-associated-Diverticulum', 'Diverticulum-associated-Diabetes Mellitus', 'Colonic Polyps-associated-Diverticulum', 'Diverticulum-associated-Colonic Polyps', 'Brain Damage, Chronic-associated-Sleep Apnea Syndromes', 'Sleep Apnea Syndromes-associated-Brain Damage, Chronic', 'Brain Damage, Chronic-increase-Dementia', 'Sleep Apnea Syndromes-increase-Dementia', 'Alzheimer Disease-associated-Cerebral Infarction', 'Cerebral Infarction-associated-Alzheimer Disease', 'Sleepiness-associated-Sleep Initiation and Maintenance Disorders', 'Sleep Initiation and Maintenance Disorders-associated-Sleepiness', 'Chronic Disease-associated-Sleep Initiation and Maintenance Disorders', 'Sleep Initiation and Maintenance Disorders-associated-Chronic Disease', 'Constipation-exclude-Mastocytosis, Systemic', 'Obesity-provoke-Venous Thromboembolism', 'Neurodegenerative Diseases-describe-Atherosclerosis', 'Neurodegenerative Diseases-describe-Nephrosclerosis', 'Amyotrophic Lateral Sclerosis-reported-Dementia', 'Neurodegenerative Diseases-describe-Liver Cirrhosis', 'Neurodegenerative Diseases-describe-Fibrosis', 'Cockayne Syndrome-involve-Neurodegenerative Diseases', 'Neurodegenerative Diseases-describe-Pulmonary Disease, Chronic Obstructive', 'Neurodegenerative Diseases-describe-Osteoporosis', 'Neurodegenerative Diseases-describe-Periodontitis', 'Neurodegenerative Diseases-describe-Neoplasms', 'Fractures, Bone-require-Pain', 'Pelvic Neoplasms-paid-Hemorrhage', 'Progeria-generate-Fibrosis', 'Progeria-generate-Cardiovascular Diseases', 'Fibrosis-generate-Cardiovascular Diseases', 'Neutropenia-include-Invasive Pulmonary Aspergillosis', 'Alzheimer Disease-characterized-Cerebral Hemorrhage', 'Iatrogenic Disease-complicate-Brain Diseases', 'Brain Diseases-increase-Dementia', 'Esophageal Neoplasms-considered-Respiratory Tract Diseases', 'Esophageal Neoplasms-suffer-Respiratory Tract Diseases', 'Pneumonia-attributed-Pneumococcal Infections', 'Heart Diseases-improve-Death', 'Neoplasms-improve-Death', 'Ventricular Dysfunction-carry-Cardiomyopathies', 'Alzheimer Disease-characterized-Cerebral Infarction', 'Alzheimer Disease-characterized-Plaque, Amyloid', 'Multiple Sclerosis-caused-Optic Neuritis', 'Ganglion Cysts-caused-Optic Neuritis', 'Fatigue-experience-Chronic Disease', 'Neoplasms-cause-Fatigue', 'Fatigue-include-Inflammation', 'Metabolic Diseases-seen-Polycystic Ovary Syndrome', 'Osteoporosis-screened-Bone Neoplasms', 'Fatigue-related-Cardiac Output, Low', 'Death-assigned-Neoplasms', 'Death-assigned-Cardiovascular Diseases', 'Coronary Artery Disease-correlated-Hypotension', 'Hypocapnia-combined-Hypotension', 'Coronary Artery Disease-place-Brain Ischemia', 'Urogenital Abnormalities-followed-Cardiovascular Diseases', 'Neoplasms-followed-Cardiovascular Diseases', 'Diabetes Mellitus-examine-Dementia', 'Thalassemia-survive-Heart Diseases', 'Thalassemia-accumulate-Drug-Related Side Effects and Adverse Reactions', 'Heart Diseases-tolerate-Drug-Related Side Effects and Adverse Reactions', 'Kidney Diseases-develop-Hypertension', 'Ocular Hypertension-consist-Cataract', 'Hyperuricemia-related-Infarction', 'Hyperuricemia-control-Infarction', 'Hyperuricemia-related-Hypertension', 'Hepatitis B-associated-Proteinuria', 'Proteinuria-associated-Hepatitis B', 'Restless Legs Syndrome-report-Sleep Wake Disorders', 'Sleep Wake Disorders-reduce-Fatigue', 'Osteoarthritis-related-Fatigue', 'Osteoarthritis-reduce-Fatigue', 'Cardiovascular Diseases-defined-Diabetes Mellitus', 'Joint Dislocations-bear-Fractures, Bone', 'Coronary Artery Disease-defined-Diabetes Mellitus', 'Fractures, Bone-suffer-Chronic Disease', 'Cataract-diminish-Blindness', 'Obesity-report-Pain', 'Hypertrophy-determine-Mitochondrial Diseases', 'Hypertrophy-determine-Sarcopenia', 'Cardiovascular Diseases-decrease-Death', 'Obesity, Abdominal-predict-Death', 'Giardiasis-associated-Infections', 'Infections-associated-Giardiasis', 'Giardiasis-associated-Diarrhea', 'Diarrhea-associated-Giardiasis', 'Giardiasis-associated-Mastocytosis, Systemic', 'Mastocytosis, Systemic-associated-Giardiasis', 'Infections-associated-Diarrhea', 'Diarrhea-associated-Infections', 'Mitochondrial Diseases-implicated-Parkinson Disease', 'Mitochondrial Diseases-implicated-Amyotrophic Lateral Sclerosis', 'Acidosis, Lactic-associated-Death', 'Death-associated-Acidosis, Lactic', 'Kidney Diseases-associate-Liver Failure', 'Liver Failure-associate-Kidney Diseases', 'Osteoarthritis-affected-Obesity', 'Osteoarthritis-prevent-Pain', 'Brain Death-show-Death', 'Wounds and Injuries-associated-Brain Death', 'Brain Death-associated-Wounds and Injuries', 'Carcinoma, Merkel Cell-present-Neoplasms', 'Carcinoma, Merkel Cell-distinguish-Neoplasms', 'Carcinoma, Merkel Cell-combined-Neoplasms', 'Ocular Motility Disorders-associated-Dementia', 'Dementia-associated-Ocular Motility Disorders', 'Lewy Body Disease-include-Ocular Motility Disorders', 'Hereditary Breast and Ovarian Cancer Syndrome-include-Ocular Motility Disorders', 'Supranuclear Palsy, Progressive-include-Ocular Motility Disorders', 'Dementia-include-Hereditary Breast and Ovarian Cancer Syndrome', 'Dementia-include-Supranuclear Palsy, Progressive', 'Dementia-associated-Supranuclear Palsy, Progressive', 'Supranuclear Palsy, Progressive-associated-Dementia', 'Dementia-associated-Creutzfeldt-Jakob Syndrome', 'Creutzfeldt-Jakob Syndrome-associated-Dementia', 'Atherosclerosis-define-Alzheimer Disease', 'Atherosclerosis-influence-Brain Infarction', 'Alzheimer Disease-influence-Brain Infarction', 'Dementia-related-Intracranial Arteriosclerosis', 'Dementia-related-Infarction', 'Pulmonary Fibrosis-emerge-Death', 'Pulmonary Fibrosis-emerge-Scleroderma, Systemic', 'Neurodegenerative Diseases-resist-Mitochondrial Diseases', 'Mitochondrial Diseases-cause-Blindness', 'Heart Failure-accounted-Death', 'Hypogonadism-coined-Headache Disorders, Secondary', 'Skin Diseases-treat-Liver Diseases', 'Skin Diseases-treat-Ulcer', 'Skin Diseases-treat-Inflammation', 'Skin Diseases-treat-Metabolic Diseases', 'Mitochondrial Diseases-induce-Inflammation', 'Hypertrophy-suggested-Mitochondrial Diseases', 'Hypertrophy-suggested-Inflammation', 'Hyperplasia-suggested-Mitochondrial Diseases', 'Hyperplasia-suggested-Inflammation', 'Arbovirus Infections-induce-Inflammation', 'Death-characterized-Fever', 'Heredodegenerative Disorders, Nervous System-characterized-Fever', 'Lipodystrophy-revert-Metabolic Diseases', 'Communicable Diseases-determined-Death', 'Acquired Immunodeficiency Syndrome-occur-Bone Neoplasms', 'Acquired Immunodeficiency Syndrome-associated-Bone Neoplasms', 'Bone Neoplasms-associated-Acquired Immunodeficiency Syndrome', 'Periodontitis-associated-Myotonic Dystrophy', 'Myotonic Dystrophy-associated-Periodontitis', 'Scoliosis-complete-Back Pain', 'Scoliosis-complete-Pain', 'Death-increase-Weight Loss', 'Neoplasms-accelerate-Weight Loss', 'Death-accelerate-Weight Loss', 'Delirium-compared-Death', 'Aortic Diseases-associated-Aortitis', 'Aortitis-associated-Aortic Diseases', 'Aortic Aneurysm, Thoracic-include-Aortitis', 'Aortic Aneurysm, Thoracic-include-Aneurysm', 'Aortic Aneurysm, Thoracic-include-Atherosclerosis', 'Drug-Related Side Effects and Adverse Reactions-induce-Necrosis', 'Diabetes Mellitus-determined-Cardiovascular Diseases', 'Mouth Diseases-remain-Periodontal Diseases', 'Hyperlipidemias-determined-Cardiovascular Diseases', 'Neurodegenerative Diseases-expressed-Hypothalamic Neoplasms', 'Atherosclerosis-induced-Cerebral Hemorrhage', 'Death-noted-Alzheimer Disease', 'Death-deceased-Alzheimer Disease', 'Death-noted-Dementia', 'Death-deceased-Dementia', 'Alzheimer Disease-mentioned-Cardiovascular Diseases', 'Alzheimer Disease-mentioned-Neoplasms', 'Alzheimer Disease-mentioned-Endocrine System Diseases', 'Dementia-mentioned-Cardiovascular Diseases', 'Dementia-mentioned-Neoplasms', 'Dementia-mentioned-Endocrine System Diseases', 'Death-related-HIV Infections', 'HIV Infections-compare-Chronic Disease', 'Death-compare-Chronic Disease', 'HIV Infections-rank-Chronic Disease', 'Renal Insufficiency-include-Chronic Disease', 'Cerebral Infarction-caused-Arteriosclerosis', 'Death-come-Stroke', 'Brain Diseases-caused-Hypotension', 'Brain Diseases-confused-Wounds and Injuries', 'Hypotension-confused-Wounds and Injuries', 'Intracranial Hemorrhages-complicate-Hypertension', 'Vasculitis-cause-Stroke', 'Hemorrhage-arise-Neoplasms', 'Erectile Dysfunction-associated-Heart Failure', 'Heart Failure-associated-Erectile Dysfunction', 'Erectile Dysfunction-underlie-Cardiovascular Diseases', 'Heart Failure-underlie-Cardiovascular Diseases', 'Erectile Dysfunction-review-Heart Failure', 'Heart Failure-minimize-Erectile Dysfunction', 'Kidney Diseases-lead-Kidney Failure, Chronic', 'Renal Insufficiency, Chronic-proposed-Kidney Diseases', 'Dementia-accomplish-Stroke', 'Diabetes Insipidus-present-Central Nervous System Cysts', 'Central Nervous System Cysts-cause-Diabetes Insipidus, Neurogenic', 'Cardiovascular Diseases-abstracted-Death', 'Optic Nerve Diseases-cause-Vision Disorders', 'Optic Atrophy, Hereditary, Leber-cause-Vision Disorders', 'Optic Atrophy-cause-Vision Disorders', 'Shock, Septic-followed-Death', 'Multiple Organ Failure-followed-Death', 'Non-alcoholic Fatty Liver Disease-link-Cardiovascular Diseases', 'Heart Diseases-develop-Cardiomyopathies', 'Adenocarcinoma-occur-Hereditary Breast and Ovarian Cancer Syndrome', 'Headache-transform-Migraine with Aura', 'Carcinogenesis-facilitate-Neoplasms', 'Ventricular Dysfunction, Right-range-Death', 'Pain-suffer-Migraine with Aura', 'Migraine with Aura-show-Pain', 'Migraine Disorders-keep-Brain Diseases', 'Cystic Fibrosis-complicate-Diabetes Mellitus', 'Genetic Diseases, Inborn-complicate-Diabetes Mellitus', 'Diabetes Mellitus-seen-Diabetes Mellitus, Type 2', 'Hemorrhage-occur-Wounds and Injuries', 'Hemorrhage-promote-Death', 'Hyperhomocysteinemia-determine-Cardiovascular Diseases', 'Hyperhomocysteinemia-determine-Abnormalities, Drug-Induced', 'Hyperhomocysteinemia-determine-Neoplasms', 'Malnutrition-indicate-Obesity', 'Kidney Failure, Chronic-progress-Renal Insufficiency, Chronic', 'Sleep Wake Disorders-considered-Chronic Disease', 'Kidney Diseases-develop-Diabetes Mellitus', 'Lung Neoplasms-lead-Kidney Diseases', 'Kidney Diseases-compared-Hypertension', 'Kidney Diseases-compared-Diabetes Mellitus', 'Intracranial Arteriosclerosis-emerge-Dementia', 'Intracranial Arteriosclerosis-emerge-Alzheimer Disease', 'Atherosclerosis-emerge-Dementia', 'Atherosclerosis-emerge-Alzheimer Disease', 'Death-augmented-Stomach Neoplasms', 'Death-augmented-Neoplasms', 'Neoplasms-augmented-Stomach Neoplasms', 'Multiple Myeloma-take-Drug-Related Side Effects and Adverse Reactions', 'Adrenal Insufficiency-associated-Chronic Disease', 'Chronic Disease-associated-Adrenal Insufficiency', 'Lung Diseases-play-Death', 'Epilepsy, Post-Traumatic-predict-Cerebrovascular Disorders', 'Skull Fractures-predict-Cerebrovascular Disorders', 'Vomiting-predict-Cerebrovascular Disorders', 'Unconsciousness-predict-Cerebrovascular Disorders', 'Blood Coagulation Disorders-predict-Cerebrovascular Disorders', 'Cataract-follow-Retinal Diseases', 'Cataract-remain-Blindness', 'Fractures, Bone-prevent-Inflammation', 'Metabolic Diseases-cause-Death', 'Cardiovascular Diseases-found-Death', 'Acquired Immunodeficiency Syndrome-continue-Death', 'Acquired Immunodeficiency Syndrome-cause-Death', 'Death-adjusted-Kidney Diseases', 'Death-calculated-Kidney Diseases', 'Methemoglobinemia-lead-Nervous System Diseases', 'Methemoglobinemia-lead-Death', 'Renal Insufficiency, Chronic-compounded-Hypothyroidism', 'Kidney Diseases-attributed-Hypothyroidism', 'Kidney Diseases-compounded-Hypothyroidism', 'Respiratory Insufficiency-suffer-Death', 'Fractures, Bone-sustain-Osteoporosis', 'Periodontal Diseases-contribute-Inflammation', 'Periodontal Diseases-associated-Inflammation', 'Inflammation-associated-Periodontal Diseases', 'Acute Kidney Injury-render-Kidney Diseases', 'Obesity-range-Diabetes Mellitus', 'Teratoma-derived-Neoplasms', 'Gait Disorders, Neurologic-render-Parkinsonian Disorders', 'Parkinson Disease-render-Parkinsonian Disorders', 'Gait Disorders, Neurologic-observed-Parkinson Disease', 'Gait Disorders, Neurologic-treat-Parkinsonian Disorders', 'Parkinson Disease-treat-Parkinsonian Disorders', 'Diabetes Mellitus-report-Pain', 'Diabetes Mellitus-report-Arthritis', 'Obesity-report-Urinary Incontinence', 'Diabetes Mellitus-emerge-Coronary Artery Disease', 'Hip Fractures-occur-Vision Disorders', 'Dementia-predicted-Alzheimer Disease', 'Dementia-predicted-Stroke', 'Alzheimer Disease-predicted-Dementia, Vascular', 'Alzheimer Disease-predicted-Stroke', 'Dementia, Vascular-predicted-Stroke', 'Dementia, Vascular-predicted-Alzheimer Disease', 'Stroke-predicted-Alzheimer Disease', 'Cartilage Diseases-seen-Osteoarthritis', 'Hypotension-examined-Hip Fractures', 'Dystonia-examined-Hip Fractures', 'Cartilage Diseases-obtained-Osteoarthritis', 'Cartilage Diseases-suggest-Osteoarthritis', 'Sinusitis-referred-Headache Disorders, Secondary', 'Myalgia-associated-Neoplasms', 'Neoplasms-associated-Myalgia', 'Muscular Diseases-associated-Neoplasms', 'Neoplasms-associated-Muscular Diseases', 'Ventricular Septal Rupture-result-Airway Obstruction', 'Ventricular Septal Rupture-result-Heart Block', 'Atrophy-used-Alzheimer Disease', 'Dementia-appear-Learning Disabilities', 'Immunologic Deficiency Syndromes-caused-Malnutrition', 'Sarcopenia-mediated-Heart Arrest', 'Chronic Disease-appear-Inflammation', 'Chronic Disease-see-Airway Obstruction', 'Death-undergo-Arterio-Arterial Fistula', 'Renal Insufficiency, Chronic-identify-Cardiovascular Diseases', 'Bone Neoplasms-thought-Hyperparathyroidism', 'Immunologic Deficiency Syndromes-play-Bone Neoplasms', 'Inflammation-suggested-Pulmonary Disease, Chronic Obstructive', 'Drug-Related Side Effects and Adverse Reactions-encountered-Bone Marrow Diseases', 'Drug-Related Side Effects and Adverse Reactions-encountered-Pneumonia', 'Death-undergo-Angina, Stable', 'Death-consider-Acute Coronary Syndrome', 'Neurologic Manifestations-occur-Critical Illness', 'Neurologic Manifestations-occur-Shock, Septic', 'Neurologic Manifestations-occur-Drug-Related Side Effects and Adverse Reactions', 'Tachycardia-cause-Neurologic Manifestations', 'Hypertension-cause-Neurologic Manifestations', 'Metabolic Diseases-cause-Neurologic Manifestations', 'Prostatic Neoplasms-associated-Coronary Artery Disease', 'Coronary Artery Disease-associated-Prostatic Neoplasms', 'Heart Failure-fill-Death', 'Death-fill-Neoplasms', 'Lupus Erythematosus, Systemic-exhibit-Neoplasms', 'Lupus Erythematosus, Systemic-exhibit-Lymphoma, Non-Hodgkin', 'Lupus Erythematosus, Systemic-exhibit-Hodgkin Disease', 'Lymphoma, Non-Hodgkin-include-Neoplasms', 'Candidiasis-divided-Cheilitis', 'Lupus Erythematosus, Systemic-develop-Neoplasms', 'Dysgeusia-lead-Malnutrition', 'Candidiasis, Oral-threaten-Neoplasm Invasiveness', 'Death-influence-Obesity', 'Communicable Diseases-influence-Obesity', 'Carcinoma, Hepatocellular-occur-End Stage Liver Disease', 'Carcinoma, Hepatocellular-occur-Inflammation', 'Carcinoma, Hepatocellular-occur-Fibrosis', 'Inflammation-provoke-Diarrhea', 'Diarrhea-develop-Colitis', 'Diarrhea-develop-Intestinal Pseudo-Obstruction', 'Dementia-divide-Alzheimer Disease', 'Hypertension-manage-Diabetes Mellitus', 'Hypertension-manage-Renal Insufficiency, Chronic', 'Renal Insufficiency, Chronic-focus-Hypertension', 'Sotos Syndrome-promote-Neurodegenerative Diseases', 'Death-promote-Cardiovascular Abnormalities', 'Scoliosis-show-Movement Disorders', 'Alzheimer Disease-caused-Neurodegenerative Diseases', 'Alzheimer Disease-caused-Nerve Degeneration', 'Neoplasm Metastasis-increase-Nervous System Diseases', 'Skin Neoplasms-show-Cardiovascular Diseases', 'Heredodegenerative Disorders, Nervous System-present-Hydrocephalus', 'Heredodegenerative Disorders, Nervous System-include-Dementia', 'Heredodegenerative Disorders, Nervous System-include-Supranuclear Palsy, Progressive', 'Heredodegenerative Disorders, Nervous System-include-Lewy Body Disease', 'Heredodegenerative Disorders, Nervous System-include-Retinal Degeneration', 'Heredodegenerative Disorders, Nervous System-include-Huntington Disease', 'Heredodegenerative Disorders, Nervous System-include-Creutzfeldt-Jakob Syndrome', 'Heredodegenerative Disorders, Nervous System-include-Atrophy', 'Hydrocephalus-include-Dementia', 'Hydrocephalus-include-Supranuclear Palsy, Progressive', 'Hydrocephalus-include-Lewy Body Disease', 'Hydrocephalus-include-Retinal Degeneration', 'Hydrocephalus-include-Huntington Disease', 'Hydrocephalus-include-Creutzfeldt-Jakob Syndrome', 'Carcinogenesis-account-Neoplasms', 'Spinal Cord Injuries-assess-Neurodegenerative Diseases', 'Spondylosis-caused-Wounds and Injuries', 'Kidney Failure, Chronic-associate-Proteinuria', 'Proteinuria-associate-Kidney Failure, Chronic', 'Constriction, Pathologic-caused-Wounds and Injuries', 'Spinal Cord Injuries-caused-Wounds and Injuries', 'Critical Illness-associated-Neoplasms', 'Neoplasms-associated-Critical Illness', 'Peptic Ulcer-prevent-Hemorrhage', 'Peptic Ulcer-based-Infections', 'Urinary Bladder Diseases-considered-Diabetes Mellitus', 'Parasitic Diseases-investigate-Death', 'Parasitic Diseases-investigate-Chagas Disease', 'Hearing Loss-result-Hearing Loss, Central', 'Diabetes Mellitus-coupled-Fractures, Bone', 'Pain-caused-Skin Diseases', 'Mastocytosis, Cutaneous-range-Psoriasis', 'Mastocytosis, Cutaneous-range-Acne Vulgaris', 'Progeria-result-Atherosclerosis', 'Death-occur-Fatigue', 'Death-occur-Anorexia', 'Death-occur-Exanthema', 'Death-occur-Deglutition Disorders', 'Gastroesophageal Reflux-include-Deglutition Disorders', 'Gastroesophageal Reflux-include-Vomiting', 'Ischemia-used-Atrial Fibrillation', 'Ischemia-used-Tachycardia, Ventricular', 'Ischemia-used-Tachycardia, Supraventricular', 'Ischemia-used-Ventricular Fibrillation', 'Arrhythmias, Cardiac-preceded-Ischemia', 'Ventricular Dysfunction, Left-show-Arrhythmias, Cardiac', 'Neuromuscular Diseases-associated-Tremor', 'Tremor-associated-Neuromuscular Diseases', 'Cardiovascular Diseases-rise-Death', 'Headache Disorders, Secondary-reported-Pain', 'Headache Disorders, Secondary-reported-Sleep Initiation and Maintenance Disorders', 'Pain-reported-Sleep Initiation and Maintenance Disorders', 'Pain-reported-Dyspnea', 'Pain-reported-Diarrhea', 'Pain-reported-Constipation', 'Neoplasms-affect-Glioma', 'Sleep Initiation and Maintenance Disorders-reported-Dyspnea', 'Sleep Initiation and Maintenance Disorders-reported-Diarrhea', 'Sleep Initiation and Maintenance Disorders-reported-Constipation', 'Otitis-include-Diabetes Mellitus', 'Mastoiditis-include-Diabetes Mellitus', 'Weight Loss-investigate-Infections', 'Weight Loss-investigate-Neoplasms', 'Glucose Intolerance-manifest-Diabetes Mellitus', 'Muscular Dystrophies-cause-Hemorrhage', 'Gingival Hyperplasia-cause-Hemorrhage', 'Cardiomyopathy, Hypertrophic-serve-Death, Sudden', 'Cardiomyopathy, Hypertrophic-regarded-Death', 'Proteinuria-associated-Kidney Failure, Chronic', 'Kidney Failure, Chronic-associated-Proteinuria', 'Signs and Symptoms, Respiratory-include-Death', 'Arthritis, Rheumatoid-decrease-Death', 'Drug-Related Side Effects and Adverse Reactions-studied-Dementia', 'Neoplasms-suggest-Diabetes Mellitus', 'Neoplasms-become-Adenocarcinoma', 'Neoplasms-become-Obesity', 'Adenocarcinoma-become-Obesity', 'Neoplasms-vary-Urinary Bladder Diseases', 'Urinary Bladder Diseases-vary-Breast Neoplasms', 'Ovarian Neoplasms-removed-Leiomyoma', 'Ovarian Neoplasms-removed-Endometriosis', 'Labor Pain-include-Fecal Incontinence', 'Wounds and Injuries-include-Fecal Incontinence', 'Inflammation-incorporate-Neoplasms', 'Blister-produce-Glioma', 'Drug Hypersensitivity-masked-Stomach Neoplasms', 'Lipodystrophy-represent-Hypertrophy', 'Aging, Premature-characterized-Metabolic Diseases', 'Rhinitis, Vasomotor-relate-Ischemia', 'Ventricular Remodeling-lead-Heart Failure', 'Diabetes Mellitus-assessed-Nervous System Diseases', 'Diabetes Mellitus-assessed-Communication Disorders', 'Diabetes Mellitus-assessed-Foot Deformities', 'Metabolic Syndrome-link-Erectile Dysfunction', 'Sleep Initiation and Maintenance Disorders-associated-Arthralgia', 'Arthralgia-associated-Sleep Initiation and Maintenance Disorders', 'Photosensitivity Disorders-undergo-Skin Neoplasms', 'Anemia-accounted-Myelodysplastic Syndromes', 'Lymphangiectasis, Intestinal-seen-Angiodysplasia', 'Lymphangiectasis, Intestinal-seen-Gastrointestinal Hemorrhage', 'Neural Tube Defects-include-Hypertension', 'Breast Neoplasms-suffer-Diabetes Mellitus', 'Breast Neoplasms-go-Death', 'Immunologic Deficiency Syndromes-include-Hypogonadism', 'Lung Neoplasms-use-Death', 'Lung Neoplasms-use-Neoplasms', 'Myocardial Infarction-arise-Atherosclerosis', 'Stroke-arise-Atherosclerosis', 'Atherosclerosis-make-Death', 'Coronary Artery Disease-remain-Diabetes Mellitus', 'Peripheral Vascular Diseases-remain-Diabetes Mellitus', 'Astigmatism-exhibit-Esotropia', 'Osteoarthritis-include-Rheumatic Diseases', 'Arthritis-include-Rheumatic Diseases', 'Bursitis-include-Rheumatic Diseases', 'Bursitis-include-Pain', 'Confusion-result-Death', 'Ischemia-result-Death', 'Giant Cell Arteritis-progress-Blindness', 'Ear Diseases-document-Blindness', 'Tooth Erosion-pursue-Osteoarthritis', 'Pain-originate-Cartilage Diseases', 'Retinal Degeneration-observed-Neuronal Ceroid-Lipofuscinoses', 'Dementia-associated-Brain Injuries', 'Brain Injuries-associated-Dementia', 'Osteoarthritis-associated-Drug-Related Side Effects and Adverse Reactions', 'Drug-Related Side Effects and Adverse Reactions-associated-Osteoarthritis', 'Inflammation-render-Drug-Related Side Effects and Adverse Reactions', 'Ataxia Telangiectasia-contribute-Cardiovascular Diseases', 'Immunologic Deficiency Syndromes-investigated-Aneurysm', 'Erectile Dysfunction-lead-Blood Coagulation Disorders', 'Erectile Dysfunction-affect-Diabetes Mellitus', 'Blood Coagulation Disorders-lead-Diabetes Mellitus', 'Diabetes Mellitus-diagnosed-Sleep Initiation and Maintenance Disorders', 'Diabetes Mellitus-diagnosed-Hypoglycemia', 'Hip Fractures-suffer-Pain', 'Pain-recover-Hip Fractures', 'Leukemia, Myeloid, Acute-account-Leukemia', 'Hypothyroidism-present-Alzheimer Disease', 'Epiglottitis-decrease-Death', 'Death-remain-Epiglottitis', 'Neoplasms-focus-Brain Neoplasms', 'Machado-Joseph Disease-reveal-Nerve Degeneration', 'Arthritis, Rheumatoid-identified-Lymphopenia', 'Periodontal Diseases-monitor-Inflammation', 'Pain-expose-Drug-Related Side Effects and Adverse Reactions', 'Dementia-flagged-Alzheimer Disease', 'Inflammation-link-Diabetes Mellitus', 'Obesity-identified-Immunologic Deficiency Syndromes', 'Metabolic Syndrome-identified-Immunologic Deficiency Syndromes', 'Diabetes Mellitus-identified-Immunologic Deficiency Syndromes', 'Hypertensive Encephalopathy-increase-Death', 'Carcinogenesis-result-Skin Neoplasms', 'Pain-sustain-Fractures, Bone', 'Fractures, Bone-leave-Metabolic Syndrome', 'Infections-considered-Neoplasms', 'Sleep Wake Disorders-represent-Muscle Weakness', 'Metabolic Syndrome-report-Diabetes Mellitus', 'Sclerosis-associated-Epilepsy, Temporal Lobe', 'Epilepsy, Temporal Lobe-associated-Sclerosis', 'Sclerosis-associated-Multiple Sclerosis', 'Multiple Sclerosis-associated-Sclerosis', 'Sclerosis-associated-Epilepsies, Myoclonic', 'Epilepsies, Myoclonic-associated-Sclerosis', 'Arthritis-present-Hypertension', 'Death-include-Kidney Diseases', 'Dementia-resemble-Alzheimer Disease', 'Infections-lead-Lung Diseases', 'Neoplasms-implicated-Heart Arrest', 'Diabetes Mellitus-improve-Hypertension', 'Death-develop-Staphylococcal Infections', 'Liver Diseases-develop-Staphylococcal Infections', 'Radius Fractures-receive-Wounds and Injuries', 'Radius Fractures-suffer-Fractures, Bone', 'Diarrhea-explore-Infections', 'Diabetes Mellitus-estimated-Death', 'Sexual Dysfunction, Physiological-manifest-Erectile Dysfunction', 'Sexual Dysfunction, Physiological-manifest-Dyspareunia', 'Intestinal Diseases-cause-Malabsorption Syndromes', 'Malabsorption Syndromes-cause-Diarrhea', 'Malabsorption Syndromes-cause-Weight Loss', 'Diabetes Mellitus-suffer-Atherosclerosis', 'Cardiovascular Diseases-give-Atherosclerosis', 'Cardiovascular Diseases-enclosed-Atherosclerosis', 'Drug Hypersensitivity-defined-Fever', 'Drug Hypersensitivity-defined-Exanthema', 'Hypertension, Pulmonary-associated-Sarcoidosis', 'Sarcoidosis-associated-Hypertension, Pulmonary', 'Sarcoidosis-receive-Necrosis', 'Body Weight Changes-lose-Obesity', 'Inflammation-increase-Alzheimer Disease', 'Death-associated-Flavivirus Infections', 'Flavivirus Infections-associated-Death', 'Osteoporosis-concerned-Bone Neoplasms', 'Chronic Disease-aggravate-Headache', 'Osteoporotic Fractures-need-Fractures, Bone', 'Skin Diseases-proven-Pemphigus, Benign Familial', 'Osteoporosis-developed-Hip Fractures', 'Critical Illness-include-Infections', 'Drug-Related Side Effects and Adverse Reactions-treat-Alzheimer Disease', 'Mitochondrial Diseases-implicate-Alzheimer Disease', 'Alzheimer Disease-calculated-Brain Death', 'Seizures-develop-Alzheimer Disease', 'Brain Death-prevent-Alzheimer Disease', 'Craniocerebral Trauma-associated-Hearing Loss', 'Hearing Loss-associated-Craniocerebral Trauma', 'Mitochondrial Diseases-related-Neurodegenerative Diseases', 'Mitochondrial Diseases-underlie-Neurodegenerative Diseases', 'Brain Neoplasms-present-Neurotoxicity Syndromes', 'Prader-Willi Syndrome-given-Uniparental Disomy', 'Central Nervous System Neoplasms-avoided-Neoplasms', 'Neoplasms-avoided-Neurotoxicity Syndromes', 'Renal Insufficiency, Chronic-result-Chronic Kidney Disease-Mineral and Bone Disorder', 'Infections-propagate-Chemical and Drug Induced Liver Injury', 'Arteriosclerosis-characterized-Calcinosis', 'Cerebrovascular Disorders-lead-Ischemia', 'Cerebral Hemorrhage-suffer-Death', 'Cerebral Amyloid Angiopathy-reveal-Hemorrhage', 'Lymphoma, B-Cell-diagnosed-Necrosis', 'Meningeal Neoplasms-bear-Chordoma', 'Heredodegenerative Disorders, Nervous System-characterized-Heart Arrest', 'Nerve Degeneration-occur-Alzheimer Disease', 'Nerve Degeneration-occur-AIDS Dementia Complex', 'Colitis-avoid-Sepsis', 'Hepatitis, Autoimmune-characterized-Inflammation', 'Neoplasms-continued-Drug-Related Side Effects and Adverse Reactions', 'Chemical and Drug Induced Liver Injury-characterized-Inflammation', 'Inflammation-developed-Hepatitis, Autoimmune', 'Fibrosis-developed-Hepatitis, Autoimmune', 'Hepatitis, Autoimmune-considered-Primary Graft Dysfunction', 'Drug-Related Side Effects and Adverse Reactions-occur-Pneumonia', 'Drug-Related Side Effects and Adverse Reactions-include-Stomatitis', 'Communicable Diseases-follow-Acute Coronary Syndrome', 'Atrial Fibrillation-predict-Death', 'Leukocytosis-predict-Death', 'Renal Insufficiency-predict-Death', 'Cataract-increase-Cardiac Output, Low', 'Cardiovascular Diseases-remain-Neoplasms', 'Alzheimer Disease-involve-Infections', 'Alzheimer Disease-involve-Meningitis, Bacterial', 'Ovarian Neoplasms-mimic-Neoplasms', 'Skin Diseases-result-Sleep Wake Disorders', 'Death-evaluate-Osteoporosis', 'Hematologic Diseases-followed-Anti-Glomerular Basement Membrane Disease', 'Craniocerebral Trauma-recorded-Death', 'Obesity-contribute-Myotonic Dystrophy', 'Obesity-considered-Myotonic Dystrophy', 'Breast Neoplasms, Male-associated-Myotonic Dystrophy', 'Myotonic Dystrophy-associated-Breast Neoplasms, Male', 'Fever-found-Psychomotor Agitation', 'Fever-associated-Psychomotor Agitation', 'Psychomotor Agitation-associated-Fever', 'Fever-manifest-Psychomotor Agitation', 'Parkinson Disease-predict-Cardiac Output, Low', 'Irritable Bowel Syndrome-demonstrate-Fecal Incontinence', 'Fecal Incontinence-demonstrate-Accidental Injuries', 'Fecal Incontinence-demonstrate-Sleep Initiation and Maintenance Disorders', 'Irritable Bowel Syndrome-double-Fecal Incontinence', 'Tinnitus-induced-Hearing Loss', 'Tinnitus-high-frequency-Hearing Loss, Central', 'Hearing Loss-induced-Tinnitus', 'Hearing Loss-hear-Sclerosis', 'Cardiomegaly-prevent-Death', 'Cardiomegaly-show-Death', 'Autoimmune Diseases-play-Hypothyroidism', 'Myalgia-result-Hip Fractures', 'Myalgia-result-Muscular Dystrophy, Duchenne', 'Myalgia-continue-Muscular Dystrophy, Duchenne', 'Renal Insufficiency-associated-Sleep Initiation and Maintenance Disorders', 'Sleep Initiation and Maintenance Disorders-associated-Renal Insufficiency', 'Hip Fractures-continue-Muscular Dystrophy, Duchenne', 'Myalgia-associated-Hip Fractures', 'Hip Fractures-associated-Myalgia', 'Alzheimer Disease-linked-AIDS Dementia Complex', 'Infections-noted-Myelodysplastic Syndromes', 'Myelodysplastic Syndromes-increased-Death', 'Atherosclerosis-augment-Hemorrhage', 'Dyskeratosis Congenita-associated-Anemia, Aplastic', 'Anemia, Aplastic-associated-Dyskeratosis Congenita', 'Idiopathic Pulmonary Fibrosis-associated-Anemia, Aplastic', 'Anemia, Aplastic-associated-Idiopathic Pulmonary Fibrosis', 'Dementia-coordinate-Alzheimer Disease', 'Ossification, Heterotopic-undergo-Osteolysis', 'Ossification, Heterotopic-undergo-Hip Dislocation', 'Alzheimer Disease-expected-Nerve Degeneration', 'Alzheimer Disease-expected-Blood Protein Disorders', 'Alzheimer Disease-accompanied-Inflammation', 'Nerve Degeneration-accompanied-Inflammation', 'Blood Protein Disorders-accompanied-Inflammation', 'Psychoses, Substance-Induced-occur-Dementia', 'Psychoses, Substance-Induced-occur-Delirium', 'Keratoacanthoma-differ-Carcinoma, Squamous Cell', 'Mitochondrial Diseases-cause-Alzheimer Disease', 'Hemorrhage-observed-Periodontal Attachment Loss', 'Calculi-observed-Periodontal Attachment Loss', 'Diabetes Mellitus-prevented-Glucose Intolerance', 'Hyperglycemia-associated-Myotonic Dystrophy', 'Myotonic Dystrophy-associated-Hyperglycemia', 'Cerebrovascular Disorders-exaggerated-Hyperglycemia', 'Myotonic Dystrophy-exaggerated-Hyperglycemia', 'Hyperglycemia-matched-Myotonic Dystrophy', 'Infections-permit-Arbovirus Infections', 'Tuberculosis-permit-Arbovirus Infections', 'Adrenal Insufficiency-considered-Neoplasms', 'Hemophilia A-characterized-Hemorrhage', 'Autoimmune Diseases-characterized-Hemorrhage', 'Drug Hypersensitivity-play-Asthma', 'Nocturia-associated-Edema', 'Edema-associated-Nocturia', 'Airway Obstruction-resemble-Pulmonary Disease, Chronic Obstructive', 'Pulmonary Disease, Chronic Obstructive-delay-Dyspnea', 'Hypertension-estimate-Metabolic Syndrome', 'Lung Diseases, Interstitial-related-Scleroderma, Systemic', 'Lung Diseases, Interstitial-associated-Scleroderma, Systemic', 'Scleroderma, Systemic-associated-Lung Diseases, Interstitial', 'Scleroderma, Systemic-enriched-Fibrosis', 'Lung Diseases, Interstitial-enriched-Fibrosis', 'Heart Failure-evaluated-Death', 'Heart Failure-evaluated-Atherosclerosis', 'Death-evaluated-Atherosclerosis', 'Hypertrophy-reduce-Fatigue', 'Drug-Related Side Effects and Adverse Reactions-result-Hypertrophy', 'Hypertrophy-result-Inflammation', 'HIV Infections-induce-Hypertrophy', 'HIV Infections-induce-Atrophy', 'Kidney Diseases-tend-Infections', 'Inflammation-related-Renal Insufficiency', 'Inflammation-fostered-Renal Insufficiency', 'Stroke-screened-Chagas Disease', 'Heart Diseases-screened-Chagas Disease', 'Thrombosis-associated-Stroke', 'Stroke-associated-Thrombosis', 'Aneurysm-associated-Stroke', 'Stroke-associated-Aneurysm', 'Pulmonary Disease, Chronic Obstructive-consist-Bronchitis', 'Pulmonary Disease, Chronic Obstructive-consist-Emphysema', 'Arbovirus Infections-play-Pulmonary Disease, Chronic Obstructive', 'Arbovirus Infections-play-Bronchitis', 'Sleep Wake Disorders-administered-Restless Legs Syndrome', 'Sleep Wake Disorders-administered-Sleep Apnea, Obstructive', 'Sleep Initiation and Maintenance Disorders-detect-Dementia', 'Dementia-report-Sleep Initiation and Maintenance Disorders', 'Dementia-report-Sleep Wake Disorders', 'Dementia-report-Restless Legs Syndrome', 'Reflex, Abnormal-present-Alkalosis', 'Cardiovascular Diseases-reflect-Hemophilia A', 'Hyperglycemia-factors-Diabetes Mellitus', 'Hyperglycemia-contribute-Diabetes Mellitus', 'Sarcopenia-result-Myalgia', 'Aneuploidy-precede-Neoplasms', 'Neoplasms-correlated-Hypoalphalipoproteinemias', 'Polyploidy-imply-Neoplasms', 'Mouth Diseases-cause-Pain', 'Inflammation-characterize-Death', 'Atherosclerosis-worsen-Inflammation', 'Alzheimer Disease-linked-Inflammation', 'Cardiovascular Diseases-induce-Brain Diseases', 'Alzheimer Disease-induce-Brain Diseases', 'Alzheimer Disease-intervene-Dementia', 'Headache Disorders, Secondary-accompanied-Sleep Apnea, Obstructive', 'Liver Diseases-projected-Death', 'Liver Diseases-result-Death', 'Ventricular Remodeling-involve-Death', 'Ventricular Remodeling-force-Death', 'Drug-Related Side Effects and Adverse Reactions-reverse-Neuroblastoma', 'Hemophilia A-complicate-Heart Diseases', 'Hemophilia A-complicate-Neoplasms', 'Hemophilia A-complicate-Kidney Diseases', 'Fractures, Bone-focus-Osteoporotic Fractures', 'Dyslipidemias-present-Diabetes Mellitus', 'Dyslipidemias-present-Metabolic Syndrome', 'Cardiomyopathies-understand-Marfan Syndrome', 'Cardiomyopathies-understand-Acromegaly', 'Endocarditis-result-Death', 'Diabetes Mellitus-address-Renal Insufficiency, Chronic', 'Diabetes Mellitus-need-Kidney Failure, Chronic', 'Renal Insufficiency, Chronic-need-Kidney Failure, Chronic', 'Endocarditis-mirror-Infections', 'Death-prevent-Chronic Disease', 'Death-prevent-Multiple Sclerosis', 'Chronic Disease-occur-Diabetes Mellitus', 'Chronic Disease-prevent-Multiple Sclerosis', 'Bone Marrow Diseases-develop-Myelodysplastic Syndromes', 'Dementia-reflect-Ossification of Posterior Longitudinal Ligament', 'Atrophy-reflect-Ossification of Posterior Longitudinal Ligament', 'Pain-include-Wounds and Injuries', 'Neurodegenerative Diseases-associated-Ataxia', 'Ataxia-associated-Neurodegenerative Diseases', 'Neurodegenerative Diseases-associated-Mitochondrial Encephalomyopathies', 'Mitochondrial Encephalomyopathies-associated-Neurodegenerative Diseases', 'Diabetes Mellitus-associated-Ataxia', 'Ataxia-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-Mitochondrial Encephalomyopathies', 'Mitochondrial Encephalomyopathies-associated-Diabetes Mellitus', 'Neoplasms-associated-Ataxia', 'Ataxia-associated-Neoplasms', 'Neoplasms-associated-Mitochondrial Encephalomyopathies', 'Mitochondrial Encephalomyopathies-associated-Neoplasms', 'Cardiovascular Diseases-associated-Ataxia', 'Ataxia-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-Mitochondrial Encephalomyopathies', 'Mitochondrial Encephalomyopathies-associated-Cardiovascular Diseases', 'Pain-associated-Gait Disorders, Neurologic', 'Gait Disorders, Neurologic-associated-Pain', 'Respiratory Tract Diseases-associated-Hip Fractures', 'Hip Fractures-associated-Respiratory Tract Diseases', 'Carcinoma, Non-Small-Cell Lung-influenced-Weight Loss', 'Death-administer-Myocardial Infarction', 'Myocardial Infarction-fail-Infarction', 'Torsades de Pointes-threatening-Arrhythmias, Cardiac', 'Tachycardia, Ventricular-threatening-Arrhythmias, Cardiac', 'Wounds and Injuries-result-Sleep Wake Disorders', 'Glaucoma-relate-Ocular Hypertension', 'Glaucoma-relate-Vision Disorders', 'Respiratory Insufficiency-occur-Delirium', 'Albuminuria-detect-Hypertension', 'Albuminuria-detect-Diabetes Mellitus', 'Albuminuria-occur-Obesity', 'Hypertension-contribute-Kidney Diseases', 'HIV Infections-affect-Bone Diseases', 'Skin Diseases-classified-Dermatitis', 'Skin Diseases-classified-Wounds and Injuries', 'Skin Diseases-classified-Infections', 'Neoplasms-managed-Prostatic Neoplasms', 'Skin Diseases-occur-Ulcer', 'Tertiary Lymphoid Structures-scored-Fibrosis', 'Tertiary Lymphoid Structures-scored-Lipomatosis', 'Necrosis-followed-Cellulitis', 'Melanoma-followed-Carcinoma, Squamous Cell', 'Wounds and Injuries-appear-Fractures, Bone', 'Anemia-develop-Heart Failure', 'Arthritis-recommend-Rheumatic Diseases', 'Death-caused-Fractures, Bone', 'Osteoporosis-refer-Fractures, Bone', 'Erectile Dysfunction-share-Coronary Artery Disease', 'Erectile Dysfunction-share-Diabetes Mellitus', 'Erectile Dysfunction-share-Hypertension', 'Sleep Apnea Syndromes-recognized-Death', 'Hypoxia-caused-Apnea', 'Hernias, Diaphragmatic, Congenital-suffer-Back Pain', 'Hernia-suffer-Back Pain', 'Cerebral Infarction-recognized-Fabry Disease', 'Fabry Disease-recognized-Stroke', 'Fabry Disease-develop-Cerebral Hemorrhage', 'Fabry Disease-associated-Ischemia', 'Ischemia-associated-Fabry Disease', 'Fabry Disease-associated-Stroke', 'Stroke-associated-Fabry Disease', 'Lysosomal Storage Diseases-result-Fabry Disease', 'Genetic Diseases, Inborn-affect-Psychoses, Substance-Induced', 'Werner Syndrome-link-Mitochondrial Diseases', 'Mitochondrial Diseases-feature-Werner Syndrome', 'Werner Syndrome-feature-Mitochondrial Diseases', 'Hemophilia A-document-Atrial Fibrillation', 'Cerebral Infarction-increased-Syncope', 'Hemorrhage-threat-Stroke', 'Heart Diseases-inhibit-Neoplasms', 'Chemical and Drug Induced Liver Injury-suffer-Death', 'Ataxia Telangiectasia-result-Death', 'Acro-Osteolysis-identified-Bone Neoplasms', 'Fractures, Bone-prevent-Osteoporotic Fractures', 'Neoplasms-caused-Parathyroid Neoplasms', 'Fractures, Open-related-Ossification of Posterior Longitudinal Ligament', 'Fractures, Open-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-Fractures, Open', 'Neoplasms-prevent-Adenocarcinoma of Lung', 'Adenoma-provide-Adenocarcinoma of Lung', 'Chemical and Drug Induced Liver Injury-simulate-Liver Failure', 'Pneumonia-suspected-Fever', 'Pneumonia-suspected-Cough', 'Pneumonia-suspected-Dyspnea', 'Heart Failure-present-Cardiac Output, Low', 'Xeroderma Pigmentosum-exhibit-Skin Neoplasms', 'Xeroderma Pigmentosum-exhibit-Neurodegenerative Diseases', 'Neoplasms-referred-Carcinogenesis', 'Breast Neoplasms-prompt-Neoplasms', 'Ichthyosis, X-Linked-precipitate-Atrial Fibrillation', 'Hip Fractures-viewed-Fractures, Bone', 'Death-related-Skin Neoplasms', 'Arrhythmias, Cardiac-mimic-Mitral Valve Stenosis', 'Airway Obstruction-mimic-Mitral Valve Stenosis', 'Bone Diseases-lead-Death', 'Osteosarcoma-derive-Bone Neoplasms', 'Neoplasms-occur-Osteosarcoma', 'Fibrosis-play-Heart Failure, Diastolic', 'Aortic Aneurysm-induce-Hypertension', 'Hypertension-induced-Retinal Degeneration', 'Hypertension-induce-Aortic Aneurysm, Abdominal', 'Hypertension-develop-Aortic Aneurysm, Abdominal', 'Atrial Fibrillation-complicate-Thromboembolism', 'Aneurysm-depend-Hypertension', 'Death-follow-Atrial Fibrillation', 'Death-follow-Heart Failure', 'Atrial Fibrillation-follow-Heart Failure', 'Kidney Failure, Chronic-linked-Obesity', 'Central Nervous System Diseases-predispose-Seizures', 'Lymphoma, Non-Hodgkin-increase-Drug-Related Side Effects and Adverse Reactions', 'Gallstones-result-Gastric Outlet Obstruction', 'Acute Kidney Injury-cause-Kidney Diseases', 'Drug-Related Side Effects and Adverse Reactions-revealed-Renal Insufficiency, Chronic', 'Glucose Intolerance-categorized-Diabetes Mellitus', 'Alzheimer Disease-related-Amyloidosis', 'Alzheimer Disease-associated-Aortic Valve Insufficiency', 'Aortic Valve Insufficiency-associated-Alzheimer Disease', 'Dementia-convert-Alzheimer Disease', 'Osteoarthritis, Hip-protect-Hip Fractures', 'Kidney Diseases-oxidize-Proteinuria', 'Obesity-corroborate-Metabolic Syndrome', 'Arthralgia-arouse-Arthritis, Rheumatoid', 'Edema-arouse-Arthritis, Rheumatoid', 'Hip Dislocation, Congenital-suggest-Polymyalgia Rheumatica', 'Kidney Diseases-suggest-Glomerulonephritis', 'Proteinuria-suggest-Glomerulonephritis', 'Glomerulonephritis-attributed-Lymphoma', 'Glomerulonephritis-related-Lymphoma', 'Glomerulonephritis-attributed-Lymphoma, B-Cell, Marginal Zone', 'Ovarian Neoplasms-compare-Neoplasms', 'Hyponatremia-associated-Myocardial Infarction', 'Myocardial Infarction-associated-Hyponatremia', 'Hearing Loss-result-Death', 'Muscular Dystrophy, Emery-Dreifuss-sustain-Hematoma', 'Sleep Apnea Syndromes-share-Alzheimer Disease', 'Aneurysm-presented-Subarachnoid Hemorrhage', 'Hypertension-result-Stroke', 'Hypotension-seen-Dementia, Vascular', 'Hypotension-prevent-Dementia, Vascular', 'Hypotension-seen-Hyperglycemia', 'Hypotension-prevent-Hyperglycemia', 'Stroke-result-Dementia, Vascular', 'Dementia, Vascular-prevent-Hyperglycemia', 'Hypertension-found-Heart Diseases', 'Hypertension-found-Hypercholesterolemia', 'Lymphoma-associated-Bone Neoplasms', 'Bone Neoplasms-associated-Lymphoma', 'Lymphoma-associated-Multiple Myeloma', 'Multiple Myeloma-associated-Lymphoma', 'Drug-Related Side Effects and Adverse Reactions-exert-Mitochondrial Diseases', 'Drug-Related Side Effects and Adverse Reactions-exert-Alzheimer Disease', 'Drug-Related Side Effects and Adverse Reactions-exert-Diabetes Mellitus, Type 2', 'Mitochondrial Diseases-exert-Alzheimer Disease', 'Mitochondrial Diseases-exert-Diabetes Mellitus, Type 2', 'Plaque, Atherosclerotic-associated-Renal Insufficiency, Chronic', 'Renal Insufficiency, Chronic-associated-Plaque, Atherosclerotic', 'Plaque, Atherosclerotic-associated-Hypertension', 'Hypertension-associated-Plaque, Atherosclerotic', 'Ischemia-occur-Diabetes Mellitus', 'Cockayne Syndrome-associated-Neurodegenerative Diseases', 'Neurodegenerative Diseases-associated-Cockayne Syndrome', 'Cockayne Syndrome-resemble-Neurodegenerative Diseases', 'Aging, Premature-associated-Neurodegenerative Diseases', 'Neurodegenerative Diseases-associated-Aging, Premature', 'Aging, Premature-resemble-Neurodegenerative Diseases', 'Diabetes Mellitus-place-Memory Disorders', 'Nerve Degeneration-lead-Alzheimer Disease', 'Urinary Incontinence, Stress-stratified-Obesity', 'Kidney Diseases-enhance-Shock', 'Lupus Erythematosus, Systemic-increased-Nervous System Diseases', 'Hypoxia-result-Sleep Apnea, Obstructive', 'Heart Failure-worsen-Death', 'Kidney Diseases-worsen-Death', 'Death-worsen-Kidney Diseases', 'Heart Failure-result-Kidney Diseases', 'Heart Failure-result-Cardiovascular Abnormalities', 'Cardiovascular Abnormalities-result-Kidney Diseases', 'Infections-cause-Hantavirus Infections', 'Neurodegenerative Diseases-result-Mitochondrial Diseases', 'Death-identified-Hypotension', 'Death-identified-Respiratory Insufficiency', 'Atrial Fibrillation-represent-Heart Failure', 'Arrhythmias, Cardiac-represent-Heart Failure', 'Skin Neoplasms-use-Death', 'Death-occur-Melanoma', 'Meningitis, Bacterial-elevate-Cerebral Infarction', 'Arbovirus Infections-elevate-Cerebral Infarction', 'Stroke-reduce-Infections', 'Leukemia-Lymphoma, Adult T-Cell-use-Neoplasms', 'Dementia-detect-Memory Disorders', 'Atherosclerosis-constitute-Stroke', 'Atherosclerosis-constitute-Heart Failure', 'Intracranial Arteriosclerosis-involved-Dementia', 'Intracranial Arteriosclerosis-involved-Alzheimer Disease', 'Alzheimer Disease-demonstrate-Hypothalamic Neoplasms', 'Hypothalamic Diseases-disrupted-Neurodegenerative Diseases', 'Alzheimer Disease-disrupted-Neurodegenerative Diseases', 'Neurotoxicity Syndromes-lead-Alzheimer Disease', 'Sleep Wake Disorders-lead-Hypoxia', 'Leukemia, Myeloid, Acute-offset-Drug-Related Side Effects and Adverse Reactions', 'Fractures, Bone-based-Hip Fractures', 'Fractures, Bone-based-Arthritis, Rheumatoid', 'Fractures, Bone-based-Osteoporosis', 'Fractures, Bone-based-Muscular Dystrophy, Duchenne', 'Peripheral Arterial Disease-address-Atherosclerosis', 'Osteoarthritis-complete-Diabetes Mellitus', 'Immunologic Deficiency Syndromes-associated-Diabetes Mellitus, Type 2', 'Diabetes Mellitus, Type 2-associated-Immunologic Deficiency Syndromes', 'Chronic Disease-determine-Acute Kidney Injury', 'Immunologic Deficiency Syndromes-associated-Coronary Artery Disease', 'Coronary Artery Disease-associated-Immunologic Deficiency Syndromes', 'Chronic Disease-exposed-Wounds and Injuries', 'Immunologic Deficiency Syndromes-associated-Stroke', 'Stroke-associated-Immunologic Deficiency Syndromes', 'Immunologic Deficiency Syndromes-associated-Ischemic Attack, Transient', 'Ischemic Attack, Transient-associated-Immunologic Deficiency Syndromes', 'Diabetes Mellitus, Type 2-improve-Metabolic Syndrome', 'Spinal Cord Diseases-reduce-Ischemia', 'Spinal Cord Diseases-reduce-Wounds and Injuries', 'Glaucoma-linked-Diabetes Mellitus', 'Communicable Diseases-linked-Diabetes Mellitus', 'Heart Failure-relieve-Dyspnea', 'Aortitis-expect-Aortic Aneurysm', 'Memory Disorders-found-Atrophy', 'Psychoses, Substance-Induced-aggregate-Alzheimer Disease', 'Alzheimer Disease-affected-Psychoses, Substance-Induced', 'Hypertension-progress-Dementia', 'Atrial Fibrillation-complicated-Ventricular Dysfunction', 'Osteoporotic Fractures-achieve-Heart Failure', 'Sleep Wake Disorders-related-Death', 'Obesity-associated-Gout', 'Gout-associated-Obesity', 'Hypertension-associated-Gout', 'Gout-associated-Hypertension', 'Brain Injuries, Traumatic-consider-Mastocytosis, Systemic', 'Pain-live-Urinary Incontinence', 'Carcinogenesis-provide-Neoplasms', 'Neoplasms-vascularized-Necrosis', 'Neoplasms-produce-Neoplasm Metastasis', 'Necrosis-produce-Neoplasm Metastasis', 'Acute Kidney Injury-treated-Hemorrhage', 'Hypovolemia-related-Drug-Related Side Effects and Adverse Reactions', 'Hypovolemia-related-Kidney Diseases', 'Sepsis-related-Drug-Related Side Effects and Adverse Reactions', 'Sepsis-related-Kidney Diseases', 'Atrial Fibrillation-identify-Dementia', 'Cardio-Renal Syndrome-result-Death', 'Death-exclude-Tuberculosis', 'Breast Neoplasms-suggest-Neoplasms', 'Neoplasms-treat-Lung Neoplasms', 'Heart Failure-remain-Cardiovascular Diseases', 'Heart Failure-increase-Heart Failure, Diastolic', 'Obesity-register-Seizures', 'Death-show-Weight Loss', 'Rothmund-Thomson Syndrome-considered-Osteosarcoma', 'Exanthema-develop-Neoplasms', 'Cataract-develop-Neoplasms', 'Exanthema-associated-Growth Disorders', 'Growth Disorders-associated-Exanthema', 'Werner Syndrome-include-Telangiectasis', 'Genetic Diseases, Inborn-include-Telangiectasis', 'Abdominal Pain-prove-Polyarteritis Nodosa', 'Hypertension-prove-Polyarteritis Nodosa', 'Microaneurysm-prove-Polyarteritis Nodosa', 'Polyarteritis Nodosa-compare-Hypertension', 'Alzheimer Disease-selected-Hydrocephalus', 'Fatty Liver-report-Fibrosis', 'Hydrocephalus-extend-Neurodegenerative Diseases', 'Hydrocephalus-see-Neurodegenerative Diseases', 'Kidney Failure, Chronic-predicated-Chronic Kidney Disease-Mineral and Bone Disorder', 'Kidney Failure, Chronic-recognize-Chronic Kidney Disease-Mineral and Bone Disorder', 'Drug-Related Side Effects and Adverse Reactions-lead-Alzheimer Disease', 'Neoplasms-suffer-Malnutrition', 'Neoplasms-suffer-Gastrointestinal Diseases', 'Malnutrition-suffer-Cachexia', 'Malnutrition-suffer-Gastrointestinal Diseases', 'Synovial Cyst-result-Osteoarthritis', 'Intestinal Atresia-caused-Gallstones', 'Death-compared-Chronic Disease', 'Obesity-occur-Diabetes Mellitus', 'Cardiovascular Diseases-include-Hypoxia', 'Erectile Dysfunction-considered-Cardiovascular Diseases', 'Erectile Dysfunction-adjusted-Cardiovascular Diseases', 'Cardiovascular Diseases-predict-Erectile Dysfunction', 'Cardiomyopathy, Hypertrophic-associated-Atrial Fibrillation', 'Atrial Fibrillation-associated-Cardiomyopathy, Hypertrophic', 'Disease Susceptibility-encountered-Alzheimer Disease', 'Colonic Neoplasms-involve-Colorectal Neoplasms', 'Vision Disorders-calculated-Vision, Low', 'Vision Disorders-calculated-Blindness', 'Genetic Diseases, Inborn-increase-Infections', 'Neoplasms-show-Autoimmune Diseases', 'Neoplasms-show-Infections', 'Autoimmune Diseases-show-Immunologic Deficiency Syndromes', 'Infections-show-Immunologic Deficiency Syndromes', 'Venous Thrombosis-comprise-Venous Thromboembolism', 'Pulmonary Embolism-comprise-Venous Thromboembolism', 'Arthritis, Rheumatoid-resemble-Polymyalgia Rheumatica', 'Carcinoma-appear-Spondylitis, Ankylosing', 'Diabetes Mellitus-develop-Arthritis, Infectious', 'Liver Cirrhosis-develop-Arthritis, Infectious', 'Arthritis, Infectious-carry-Death', 'Stroke-associate-Cerebral Amyloid Angiopathy', 'Cerebral Amyloid Angiopathy-associate-Stroke', 'Myocardial Infarction-associate-Cerebral Amyloid Angiopathy', 'Cerebral Amyloid Angiopathy-associate-Myocardial Infarction', 'Alzheimer Disease-described-Inflammation', 'Arthritis-reduce-Communication Disorders', 'Osteoarthritis-reduce-Communication Disorders', 'Renal Insufficiency, Chronic-worsen-Hyperparathyroidism', 'Renal Insufficiency, Chronic-worsen-Chronic Kidney Disease-Mineral and Bone Disorder', 'Renal Insufficiency, Chronic-promote-Vascular Calcification', 'Urinary Incontinence, Stress-bothered-Headache Disorders, Secondary', 'Urinary Incontinence, Stress-bothered-Urinary Incontinence', 'Hyperparathyroidism-promote-Vascular Calcification', 'Urinary Incontinence-bothered-Headache Disorders, Secondary', 'Hyperparathyroidism-increase-Death', 'Brain Injuries, Traumatic-account-Hemorrhage', 'Brain Injuries, Traumatic-account-Multiple Organ Failure', 'Seizures-indexed-Cardiovascular Diseases', 'Diabetes Mellitus-undergo-Contusions', 'Glucose Metabolism Disorders-involve-HIV Infections', 'Hypertension-compare-Arthritis, Rheumatoid', 'Cataract-compare-Arthritis, Rheumatoid', 'Fractures, Bone-compare-Arthritis, Rheumatoid', 'Cardiovascular Diseases-compare-Arthritis, Rheumatoid', 'Gallbladder Diseases-compare-Arthritis, Rheumatoid', 'Endocrine System Diseases-compare-Arthritis, Rheumatoid', 'Bone Malalignment-considered-Respiratory Tract Infections', 'Bone Malalignment-considered-Neurologic Manifestations', 'Bone Malalignment-considered-Musculoskeletal Diseases', 'Neurologic Manifestations-followed-Respiratory Tract Infections', 'Musculoskeletal Diseases-followed-Respiratory Tract Infections', 'Prostatic Neoplasms-account-Death', 'Infections-include-Scabies', 'Hypothyroidism-started-Coronary Artery Disease', 'Lysosomal Storage Diseases-caused-Gaucher Disease', 'Hyperuricemia-include-Cardiovascular Diseases', 'Hypertension-include-Chronic Kidney Disease-Mineral and Bone Disorder', 'Anemia-include-Chronic Kidney Disease-Mineral and Bone Disorder', 'Inflammation-include-Chronic Kidney Disease-Mineral and Bone Disorder', 'Hyperlipidemias-include-Chronic Kidney Disease-Mineral and Bone Disorder', 'Hyperuricemia-include-Chronic Kidney Disease-Mineral and Bone Disorder', 'Cardiovascular Diseases-added-Diabetes Mellitus', 'Cardiovascular Diseases-added-Hypertension', 'Respiratory Distress Syndrome-develop-Pneumonia', 'Communicable Diseases-include-Thoracic Diseases', 'Neoplasms-associated-Pleural Effusion', 'Pleural Effusion-associated-Neoplasms', 'Autoimmune Diseases-include-Thoracic Diseases', 'Neoplasms-associated-Airway Obstruction', 'Airway Obstruction-associated-Neoplasms', 'Death-suffer-Craniocerebral Trauma', 'Shock, Hemorrhagic-suffer-Craniocerebral Trauma', 'Osteoporosis-characterize-Radius Fractures', 'Pain-report-Bradycardia', 'Thrombosis-identified-Upper Extremity Deep Vein Thrombosis', 'Sjogren-Larsson Syndrome-play-Alzheimer Disease', 'Alzheimer Disease-show-Wallerian Degeneration', 'Atherosclerosis-include-Metabolic Syndrome', 'Fractures, Bone-found-Death', 'Death-limited-Wounds and Injuries', 'Osteoporotic Fractures-sustain-Fractures, Bone', 'Pain-arise-Blister', 'Peripheral Nervous System Diseases-cause-Neuralgia', 'Pain-under-report-Myocardial Infarction', 'Pain-under-report-Fractures, Bone', 'Pain-under-report-Arthritis', 'Neurodegenerative Diseases-cause-Nervous System Diseases', 'Death-predispose-Colitis', 'Carcinoma, Hepatocellular-identified-Death', 'Diabetes Mellitus-identified-Death', 'Vision Disorders-fall-Vision, Low', 'Neurodegenerative Diseases-predispose-Parkinson Disease', 'Dementia-include-Parkinson Disease', 'Anemia-correct-Heart Failure', 'Kidney Diseases-meet-Anemia', 'Osteoporosis-accentuate-Ovarian Neoplasms', 'Muscle Weakness-include-Sepsis', 'Hematologic Diseases-result-Infections', 'Hematologic Diseases-result-Hemorrhage', 'Myelodysplastic Syndromes-transform-Leukemia, Myeloid, Acute', 'Myelodysplastic Syndromes-considered-Leukemia', 'Myositis-show-Muscle Weakness', 'Hemorrhage-performed-Anemia, Iron-Deficiency', 'Bacterial Infections-follow-Infections', 'Bacterial Infections-result-Death', 'Anemia-represent-Myelodysplastic Syndromes', 'Chromosome Aberrations-seen-Myelodysplastic Syndromes', 'Chromosome Aberrations-identify-Myelodysplastic Syndromes', 'Brain Injuries, Traumatic-cause-Rupture', 'Neurodegenerative Diseases-characterized-Necrosis', 'Muscular Dystrophies-characterized-Necrosis', 'Heart Failure-live-Death', 'Infections-characterized-Fever', 'Fever-characterized-Heredodegenerative Disorders, Nervous System', 'Arrhythmias, Cardiac-related-Ischemia', 'Kidney Diseases-affect-Retinal Diseases', 'Retinal Diseases-reduce-Diabetes Mellitus', 'Cardiovascular Diseases-suffer-Colorectal Neoplasms', 'Migraine with Aura-related-Stroke', 'Migraine with Aura-associate-Stroke', 'Stroke-associate-Migraine with Aura', 'Migraine with Aura-associate-Hypertension', 'Hypertension-associate-Migraine with Aura', 'Migraine with Aura-associated-Cerebral Infarction', 'Cerebral Infarction-associated-Migraine with Aura', 'Stroke-investigated-Migraine Disorders', 'Stroke-investigated-Headache', 'Migraine Disorders-investigated-Headache', 'Kyphosis-underlie-Osteoporosis', 'Neoplasms-arise-Hernia', 'Mesothelioma-arise-Neoplasms', 'Mesothelioma-arise-Epididymitis', 'Memory Disorders-provide-Dementia', 'Osteoporosis-determine-Osteoporotic Fractures', 'Colitis, Ischemic-analyzed-Constipation', 'Colitis, Ischemic-analyzed-Basal Ganglia Cerebrovascular Disease', 'Colitis, Ischemic-analyzed-Hepatitis C', 'Colitis, Ischemic-analyzed-Neoplasms', 'Blood Loss, Surgical-associated-Death', 'Death-associated-Blood Loss, Surgical', 'Prostatitis-implicated-Prostatic Hyperplasia', 'Sarcopenia-reverse-Death', 'Leukemia, B-Cell-associated-Immunologic Deficiency Syndromes', 'Immunologic Deficiency Syndromes-associated-Leukemia, B-Cell', 'Immunologic Deficiency Syndromes-incorporated-Lymphoma', 'Immunologic Deficiency Syndromes-associated-Lymphoma', 'Lymphoma-associated-Immunologic Deficiency Syndromes', 'Immunologic Deficiency Syndromes-associated-Lymphoma, B-Cell', 'Lymphoma, B-Cell-associated-Immunologic Deficiency Syndromes', 'Kidney Diseases-account-Acute Kidney Injury', 'Acute Kidney Injury-lead-Death', 'Acute Kidney Injury-lead-Kidney Failure, Chronic', 'Tooth Loss-lead-Diabetes Mellitus', 'Neoplasms-overtake-Heart Diseases', 'Neoplasms-increase-Carcinoma, Intraductal, Noninfiltrating', 'Neoplasms-increase-Neoplasm Invasiveness', 'Neoplasms-increase-Breast Neoplasms', 'Dementia-grouped-Alzheimer Disease', 'Infections-become-Chronic Disease', 'Femoral Neck Fractures-recommended-Dementia', 'Neoplasms-burdened-Pain', 'Immune System Diseases-represent-Pain', 'Kidney Diseases-impact-Renal Insufficiency', 'Thrombosis-develop-Postthrombotic Syndrome', 'Death-reveal-Plaque, Amyloid', 'Alzheimer Disease-fulfill-Plaque, Amyloid', 'Parental Death-associated-Agnosia', 'Agnosia-associated-Parental Death', 'Ischemia-heighten-Acute Kidney Injury', 'Acute Kidney Injury-defined-Renal Insufficiency, Chronic', 'Mitochondrial Diseases-develop-Hypertension', 'Hyperhomocysteinemia-associated-Mitochondrial Diseases', 'Mitochondrial Diseases-associated-Hyperhomocysteinemia', 'Cerebrovascular Disorders-demonstrate-Aphasia', 'Edema-develop-Purpura', 'Thalassemia-characterized-Anemia', 'Thalassemia-discuss-Cardiomyopathies', 'Thalassemia-discuss-Hypertension, Pulmonary', 'Hypertension-weaken-Death', 'Kyphosis-underlie-Fractures, Bone', 'Dementia-reduce-Alzheimer Disease', 'Hemophilia A-require-Hemorrhage', 'Kidney Diseases-induced-Multiple Myeloma', 'Multiple Myeloma-make-Kidney Diseases', 'Carcinogenesis-suppress-Skin Neoplasms', 'Dwarfism, Pituitary-cause-Death', 'Pain Insensitivity, Congenital-occur-Multiple Myeloma', 'Kidney Diseases-contribute-Drug-Related Side Effects and Adverse Reactions', 'Metabolic Syndrome-compare-Inflammation', 'Metabolic Syndrome-verified-Dementia, Vascular', 'Diabetes Mellitus-monitor-Glucose Metabolism Disorders', 'Ulcer-arise-Necrosis', 'Thoracic Outlet Syndrome-discuss-Aneurysm', 'Non-alcoholic Fatty Liver Disease-surviving-End Stage Liver Disease', 'Neurodegenerative Diseases-occur-Ischemia', 'Neurodegenerative Diseases-occur-Hydrocephalus', 'Hypercalcemia-associated-Neoplasms', 'Neoplasms-associated-Hypercalcemia', 'Hypercalcemia-associated-Neoplastic Syndromes, Hereditary', 'Neoplastic Syndromes, Hereditary-associated-Hypercalcemia', 'Metabolic Diseases-associated-Neoplastic Syndromes, Hereditary', 'Neoplastic Syndromes, Hereditary-associated-Metabolic Diseases', 'Hypercalcemia-emerge-Neoplasms', 'Hypercalcemia-emerge-Multiple Myeloma', 'Hypercalcemia-dominate-Breast Neoplasms', 'Death-promote-Inflammation', 'Carcinogenesis-reflected-Neoplasms', 'Tuberculosis, Lymph Node-suspected-Lymphoma', 'Sclerosis-characterized-Death', 'Autoimmune Diseases of the Nervous System-characterized-Fibrosis', 'Autoimmune Diseases of the Nervous System-characterized-Death', 'Neoplasms-evaluated-Death', 'Atrophy-accelerate-Alzheimer Disease', 'Dementia-defined-Psychomotor Agitation', 'Dementia-defined-Hallucinations', 'Fractures, Bone-caused-Neoplasms', 'Headache-mimic-Meningoencephalitis', 'Myocardial Infarction-treated-Alzheimer Disease', 'Diarrhea-experience-Syncope', 'Vomiting-experience-Syncope', 'Hypertension-accelerate-Dementia, Vascular', 'Hypertension-accelerate-Cerebral Small Vessel Diseases', 'Obesity-prove-Cardiovascular Diseases', 'Dementia, Vascular-accelerate-Cerebral Small Vessel Diseases', 'Mitral Valve Stenosis-associated-Atrial Fibrillation', 'Atrial Fibrillation-associated-Mitral Valve Stenosis', 'Hip Dislocation, Congenital-occur-Hemochromatosis', 'Mitochondrial Diseases-implicated-Tauopathies', 'Neurodegenerative Diseases-suffer-Tauopathies', 'Hepatitis, Autoimmune-suspected-Jaundice', 'Constipation-complicated-Urinary Incontinence', 'Gastrointestinal Diseases-reduce-Death', 'Death-involve-Pneumonia', 'Cardiovascular Diseases-increase-Infections', 'Pneumococcal Infections-include-Meningitis', 'Bacterial Infections-contribute-Death', 'Pneumococcal Infections-include-Bacteremia', 'Angina Pectoris-include-Acute Coronary Syndrome', 'Myocardial Infarction-include-Acute Coronary Syndrome', 'Neoplasms-increase-Autoimmune Diseases', 'Atrial Fibrillation-underlie-Coronary Artery Disease', 'Death-include-Muscular Diseases', 'Aortic Aneurysm, Abdominal-observed-Death', 'Thrombosis-found-Aneurysm', 'Inflammation-arise-Atherosclerosis', 'Pain-diagnose-Carcinoma, Squamous Cell', 'Dyspnea-diagnose-Carcinoma, Squamous Cell', 'Cough-diagnose-Carcinoma, Squamous Cell', 'Fatigue-diagnose-Carcinoma, Squamous Cell', 'Atrial Fibrillation-estimates-Atrial Flutter', 'Cerebrovascular Disorders-explain-Stroke', 'Diabetic Nephropathies-associated-Glomerulonephritis', 'Glomerulonephritis-associated-Diabetic Nephropathies', 'Diabetes Mellitus-accompany-Renal Insufficiency', 'Trichothiodystrophy Syndromes-vary-Fragile X Syndrome', 'Death-predict-Renal Insufficiency, Chronic', 'Urinary Incontinence-reveal-Fecal Incontinence', 'Urinary Incontinence-reveal-Stroke', 'Urinary Incontinence-reveal-Lung Diseases', 'Urinary Incontinence-reveal-Infections', 'Fecal Incontinence-include-Stroke', 'Long QT Syndrome-develop-Torsades de Pointes', 'Tachycardia, Ventricular-develop-Torsades de Pointes', 'Neoplasms-reveal-Hydrocephalus', 'Vision Disorders-defined-Malocclusion', 'Albuminuria-associated-Diabetic Nephropathies', 'Diabetic Nephropathies-associated-Albuminuria', 'Retinal Vein Occlusion-compare-Hypertension', 'Retinal Vein Occlusion-estimate-Hypertension', 'Retinal Vein Occlusion-compare-Glaucoma', 'Hypertension-defined-Dementia', 'Hypertension-defined-Alzheimer Disease', 'Atrial Fibrillation-performed-Stroke', 'Ventricular Premature Complexes-associated-Atrial Fibrillation', 'Atrial Fibrillation-associated-Ventricular Premature Complexes', 'Cardiovascular Diseases-contribute-Respiratory Insufficiency', 'Atrophy-considered-Alzheimer Disease', 'Atrophy-considered-Inflammation', 'Sarcopenia-favour-Death', 'Neoplasms-exceed-Cardiovascular Diseases', 'Neoplasms-exceed-Death', 'Cardiovascular Diseases-exceed-Death', 'Respiratory Tract Infections-improve-Neoplasms', 'Diabetes Mellitus-impair-Erectile Dysfunction', 'Infections-underlie-Diabetes Mellitus', 'Obesity-seem-Weight Loss', 'Epilepsy-identify-Brain Diseases', 'Pulmonary Disease, Chronic Obstructive-associated-Kidney Failure, Chronic', 'Kidney Failure, Chronic-associated-Pulmonary Disease, Chronic Obstructive', 'Lymphoma, B-Cell-display-Neoplasms', 'Glioblastoma-remain-Neoplasms', 'Glioblastoma-arise-Neoplasms', 'Neoplasms-increase-Cerebral Hemorrhage', 'Alzheimer Disease-persist-Aneurysm', 'Carcinoma, Hepatocellular-include-Liver Diseases', 'Cardiovascular Diseases-cause-Weight Loss', 'Joint Diseases-suffer-Pain', 'Prostatic Hyperplasia-transform-Urinary Bladder Neck Obstruction', 'Prostatitis-transform-Urinary Bladder Neck Obstruction', 'Blindness-include-Keratitis', 'Blindness-include-Wounds and Injuries', 'Pulmonary Disease, Chronic Obstructive-provide-Pain', 'Neurodegenerative Diseases-provide-Pain', 'Deglutition Disorders-present-Osteophyte', 'Osteophyte-range-Deglutition Disorders', 'Osteophyte-range-Dysphonia', 'Osteophyte-range-Dyspnea', 'Osteophyte-lead-Airway Obstruction', 'Peripheral Nervous System Diseases-recognised-Drug-Related Side Effects and Adverse Reactions', 'Hypokalemia-associated-Arrhythmias, Cardiac', 'Arrhythmias, Cardiac-associated-Hypokalemia', 'Hip Fractures-compare-Heart Failure', 'Diabetes Mellitus-predispose-Osteoporosis', 'Diabetes Mellitus-prevent-Osteoporosis', 'Soft Tissue Neoplasms-caused-Wounds and Injuries', 'Anemia-caused-Immunologic Deficiency Syndromes', 'Anemia, Pernicious-associated-Gastritis, Atrophic', 'Gastritis, Atrophic-associated-Anemia, Pernicious', 'Anemia-caused-Factor X Deficiency', 'Anemia, Pernicious-associated-Stomach Neoplasms', 'Stomach Neoplasms-associated-Anemia, Pernicious', 'Anemia, Pernicious-caused-Immunologic Deficiency Syndromes', 'Gastritis, Atrophic-based-Stomach Neoplasms', 'Anemia, Pernicious-caused-Factor X Deficiency', 'Anemia, Macrocytic-caused-Immunologic Deficiency Syndromes', 'Anemia, Macrocytic-caused-Factor X Deficiency', 'Anemia, Pernicious-seek-Anemia', 'Anemia, Pernicious-seek-Muscle Weakness', 'Anemia, Pernicious-seek-Asthenia', 'Anemia, Pernicious-associated-Thyroiditis, Autoimmune', 'Thyroiditis, Autoimmune-associated-Anemia, Pernicious', 'Anemia, Pernicious-associated-Autoimmune Diseases', 'Autoimmune Diseases-associated-Anemia, Pernicious', 'Infections-terminate-Autoimmune Diseases', 'Anemia, Pernicious-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-Anemia, Pernicious', 'Anemia, Pernicious-replaced-Autoimmune Diseases', 'Pain-decrease-Osteoarthritis', 'Renal Insufficiency, Chronic-remain-Death', 'Renal Insufficiency, Chronic-remain-Kidney Diseases', 'Osteoarthritis-demonstrate-Hyperalgesia', 'Osteoarthritis-demonstrate-Fibromyalgia', 'Kidney Diseases-compare-Death', 'Kidney Diseases-compare-Renal Insufficiency, Chronic', 'Renal Insufficiency, Chronic-experience-Acute Kidney Injury', 'Respiratory Tract Infections-bear-Asthma', 'Death-base-Multiple Organ Failure', 'Death-categorized-Multiple Organ Failure', 'Coronary Artery Disease-analysed-Death', 'Thyroid Diseases-analysed-Death', 'Thyroid Diseases-treated-Hip Fractures', 'Death-treated-Hip Fractures', 'Melanoma-design-Neoplasms', 'Inflammation-predispose-Carcinogenesis', 'Dementia-used-Alzheimer Disease', 'Anophthalmos-indicate-Hypertension', 'Anophthalmos-indicate-Glaucoma', 'Ocular Hypertension-cause-Optic Nerve Diseases', 'Ocular Hypertension-cause-Glaucoma, Open-Angle', 'Hip Fractures-constitute-Wounds and Injuries', 'Hematoma, Subdural, Acute-associated-Brain Injuries', 'Brain Injuries-associated-Hematoma, Subdural, Acute', 'Hemorrhage-predisposed-Atrophy', 'Parkinson Disease-present-Hypokinesia', 'Hypokinesia-suspected-Parkinson Disease, Secondary', 'Hypokinesia-present-Muscle Rigidity', 'Hypokinesia-present-Tremor', 'Muscle Rigidity-include-Parkinson Disease, Secondary', 'Tremor-include-Parkinson Disease, Secondary', 'Somatosensory Disorders-include-Parkinson Disease, Secondary', 'Fractures, Bone-associated-Hip Dislocation, Congenital', 'Hip Dislocation, Congenital-associated-Fractures, Bone', 'Fractures, Bone-correlate-Muscular Dystrophy, Duchenne', 'Alzheimer Disease-lead-Vestibulocochlear Nerve Injuries', 'Dementia-lead-Vestibulocochlear Nerve Injuries', 'Vestibulocochlear Nerve Injuries-lead-Death', 'Fecal Incontinence-occur-Urinary Incontinence', 'Immunologic Deficiency Syndromes-contribute-Metabolic Syndrome', 'Metabolic Syndrome-prevent-Hypogonadism', 'Lymphoma-involved-Respiratory Distress Syndrome', 'Respiratory Distress Syndrome-associated-Lymphoma', 'Lymphoma-associated-Respiratory Distress Syndrome', 'Diabetes Mellitus-influence-Alzheimer Disease', 'Hyperhomocysteinemia-lead-Atherosclerosis', 'Hyperhomocysteinemia-accelerate-Atherosclerosis', 'Arthritis-negated-Diabetes Mellitus', 'Alveolar Bone Loss-associated-Cerebrovascular Disorders', 'Cerebrovascular Disorders-associated-Alveolar Bone Loss', 'Dementia-accompany-Alzheimer Disease', 'Dementia-accelerate-Neurodegenerative Diseases', 'Alzheimer Disease-seen-Metabolic Diseases', 'Polyploidy-induce-Tetraploidy', 'Alzheimer Disease-exert-Atrophy', 'Peripheral Arterial Disease-impaired-Diabetes Mellitus', 'Atherosclerosis-implicated-Rupture', 'Atherosclerosis-implicated-Myocardial Infarction', 'Inflammation-triggered-Respiratory Tract Infections', 'Death-help-Pulmonary Disease, Chronic Obstructive', 'Death-help-Asthma', 'Death-avert-Metabolic Diseases', 'Death-avert-Diabetes Mellitus', 'Diabetes Mellitus-assessed-Hearing Loss, Central', 'Tuberculosis-base-Infections', 'Tuberculosis-made-Ascites', 'Tuberculosis-base-Ascites', 'Death-hospitalized-Acute Kidney Injury', 'Death-measured-Hip Fractures', 'Kidney Diseases-associated-Urethral Neoplasms', 'Urethral Neoplasms-associated-Kidney Diseases', 'Diabetes Mellitus-contribute-Kidney Diseases', 'Hemophilia A-associated-Hemorrhage', 'Hemorrhage-associated-Hemophilia A', 'Atrial Fibrillation-known-Thromboembolism', 'Atrial Fibrillation-known-Stroke', 'Common Cold-known-Thromboembolism', 'Common Cold-known-Stroke', 'Atrial Fibrillation-include-Dementia', 'Arrhythmias, Cardiac-include-Dementia', 'Glucose Metabolism Disorders-prevent-Colorectal Neoplasms', 'Colorectal Neoplasms-treat-Inflammatory Bowel Diseases', 'Enuresis-associated-Urinary Incontinence', 'Urinary Incontinence-associated-Enuresis', 'Atrial Fibrillation-become-Neurodegenerative Diseases', 'Alzheimer Disease-become-Neurodegenerative Diseases', 'Enuresis-link-Urinary Incontinence', 'Genetic Diseases, Inborn-underlie-Hereditary Breast and Ovarian Cancer Syndrome', 'Genetic Diseases, Inborn-underlie-Benign Paroxysmal Positional Vertigo', 'Genetic Diseases, Inborn-underlie-Deafness', 'Benign Paroxysmal Positional Vertigo-underlie-Deafness', 'Vertigo-diagnose-Vestibulocochlear Nerve Diseases', 'Cardiac Output, Low-fall-Obesity', 'Metabolic Syndrome-elevate-Obesity, Abdominal', 'Metabolic Syndrome-comprise-Obesity, Abdominal', 'Metabolic Syndrome-prove-Diabetes Mellitus', 'Diabetes Mellitus-determined-Death', 'Neoplasms-determined-Death', 'Obesity, Abdominal-specify-Cardiovascular Diseases', 'Obesity, Abdominal-specify-Atherosclerosis', 'Obesity-specify-Cardiovascular Diseases', 'Obesity-specify-Atherosclerosis', 'Infections-result-Hemolytic-Uremic Syndrome', 'Death-occur-Hemolytic-Uremic Syndrome', 'Hemolytic-Uremic Syndrome-associated-Infections', 'Infections-associated-Hemolytic-Uremic Syndrome', 'Ischemia-affected-Atherosclerosis', 'Atrial Fibrillation-remain-Arrhythmias, Cardiac', 'Vision Disorders-provide-Cataract', 'Vision Disorders-provide-Glaucoma, Open-Angle', 'Ossification of Posterior Longitudinal Ligament-associated-Muscle Spasticity', 'Muscle Spasticity-associated-Ossification of Posterior Longitudinal Ligament', 'Ossification of Posterior Longitudinal Ligament-predict-Muscle Spasticity', 'Ossification of Posterior Longitudinal Ligament-predict-Chronic Pain', 'Ossification of Posterior Longitudinal Ligament-predict-Arthralgia', 'Nerve Degeneration-induce-Alzheimer Disease', 'Disease Progression-associated-Nerve Degeneration', 'Nerve Degeneration-associated-Disease Progression', 'Disease Progression-associated-Neurodegenerative Diseases', 'Neurodegenerative Diseases-associated-Disease Progression', 'Disease Progression-occur-Neurodegenerative Diseases', 'Nerve Degeneration-occur-Neurodegenerative Diseases', 'Pain-deserve-Osteoarthritis, Hip', 'Hypertension-suggest-Alzheimer Disease', 'Dementia, Vascular-suggest-Hypertension', 'Dementia, Vascular-suggest-Alzheimer Disease', 'Arthritis, Rheumatoid-associate-Osteoarthritis', 'Osteoarthritis-associate-Arthritis, Rheumatoid', 'Arthritis, Rheumatoid-associate-Communicable Diseases', 'Communicable Diseases-associate-Arthritis, Rheumatoid', 'Osteoarthritis-lead-Obesity', 'Hyperplasia-play-Diabetes Mellitus', 'Death-enhance-Obesity', 'Death-enhance-Diabetes Mellitus', 'Osteoarthritis-allocated-Pain', 'Pleural Effusion-related-Distal Myopathies', 'HIV Infections-supplanted-Atherosclerosis', 'HIV Infections-mitigated-Hyperlipidemias', 'Atherosclerosis-magnified-Hyperlipidemias', 'Opportunistic Infections-include-Disease', 'HIV Infections-include-Disease', 'HIV Infections-render-Death', 'Acquired Immunodeficiency Syndrome-render-Death', 'Ventricular Dysfunction, Left-divided-Obesity', 'Ventricular Dysfunction, Left-overcompensate-Obesity', 'Cardiovascular Diseases-treat-Urogenital Abnormalities', 'Hypertension-foster-Hypertrophy, Left Ventricular', 'Hypertension-contribute-Heart Failure', 'Hypertension-foster-Stroke', 'Hypertrophy, Left Ventricular-contribute-Coronary Artery Disease', 'Hypertrophy, Left Ventricular-contribute-Heart Failure', 'Scleroderma, Systemic-present-Hodgkin Disease', 'Scleroderma, Systemic-present-Weight Loss', 'Scleroderma, Systemic-present-Signs and Symptoms, Digestive', 'Hodgkin Disease-present-Paraneoplastic Syndromes', 'Hodgkin Disease-present-Weight Loss', 'Lymphoma, B-Cell-present-Paraneoplastic Syndromes', 'Hodgkin Disease-present-Signs and Symptoms, Digestive', 'Scleroderma, Systemic-present-Paraneoplastic Syndromes', 'Lymphoma-present-Paraneoplastic Syndromes', 'Scleroderma, Systemic-search-Hodgkin Disease', 'Heart Failure-include-Metabolic Syndrome', 'Hyperglycemia-decreased-Hypertriglyceridemia', 'Sarcopenia-aggravated-Malnutrition', 'Metabolic Syndrome-prevent-Heart Failure', 'Hypertension-used-Heart Failure', 'Diabetes Mellitus-used-Heart Failure', 'Inflammation-incorporate-Metabolic Syndrome', 'Coronary Artery Disease-used-Heart Failure', 'Metabolic Syndrome-compare-Heart Failure', 'Metabolic Syndrome-increase-Heart Failure', 'Hypogonadism-describe-Headache Disorders, Secondary', 'Photophobia-show-Corneal Opacity', 'Communicable Diseases-linked-Death', 'Voice Disorders-result-Headache', 'Immunologic Deficiency Syndromes-known-Central Nervous System Neoplasms', 'Autoimmune Diseases-known-Central Nervous System Neoplasms', 'Arthritis, Rheumatoid-produce-Ataxia Telangiectasia', 'Diabetes Mellitus-increased-Hypertension', 'Inflammation-include-Glycogen Storage Disease Type II', 'Death-include-Lung Diseases', 'Hypertension-assess-Myocardial Infarction', 'Hypertension-suffer-Acute Kidney Injury', 'Hypertension-suffer-Shock', 'Hypertension-suffer-Cerebrovascular Disorders', 'Bronchopulmonary Dysplasia-use-Asthma', 'Colitis, Ulcerative-carry-Inflammatory Bowel Diseases', 'Memory Disorders-shown-Hepatolenticular Degeneration', 'Mastocytosis, Systemic-cause-Labyrinth Diseases', 'Prostatitis-differentiate-Prostatic Neoplasms', 'Osteoporosis-treat-Hearing Loss, Central', 'Osteoporosis-detect-Hearing Loss, Central', 'Peripheral Arterial Disease-reduce-Death', 'Death-correlated-Fractures, Bone', 'Fibrous Dysplasia of Bone-use-Pigmentation Disorders', 'Atrophy-exhibit-Nerve Degeneration', 'Vasculitis-show-Hypertension', 'Genetic Diseases, Inborn-cause-Alzheimer Disease', 'Acute Kidney Injury-encounter-Hyperkalemia', 'Diarrhea-lead-Dehydration', 'Pain-satisfied-Discitis', 'Fractures, Bone-followed-Crush Injuries', 'Heart Failure-predict-Mitral Valve Insufficiency', 'Heart Failure-predict-Heterotaxy Syndrome', 'Diabetes Mellitus-linked-Cardiovascular Diseases', 'Diabetes Mellitus-linked-Blindness', 'Diabetes Mellitus-linked-Diabetic Nephropathies', 'Diabetes Mellitus-linked-Kidney Failure, Chronic', 'Cardiovascular Diseases-result-Blindness', 'Cardiovascular Diseases-linked-Diabetic Nephropathies', 'Cardiovascular Diseases-linked-Kidney Failure, Chronic', 'Pain-associated-Exanthema', 'Exanthema-associated-Pain', 'Kidney Failure, Chronic-suffer-Uremia', 'Kidney Failure, Chronic-caused-Diabetes Mellitus', 'Uremia-caused-Diabetes Mellitus', 'Renal Insufficiency-experience-Ischemia', 'Death-remain-Kidney Failure, Chronic', 'Parkinson Disease-alleviate-Neurologic Manifestations', 'Heredodegenerative Disorders, Nervous System-characterized-Hypoxia', 'Metabolic Syndrome-known-Renal Insufficiency, Chronic', 'Metabolic Diseases-experienced-Metabolic Syndrome', 'Metabolic Diseases-experienced-Renal Insufficiency, Chronic', 'Thyroid Diseases-reported-Graves Disease', 'Cardiovascular Diseases-lead-Renal Insufficiency, Chronic', 'Renal Insufficiency, Chronic-result-Hypertension', 'Hypopituitarism-provide-Craniocerebral Trauma', 'Paraplegia-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-Paraplegia', 'Paraplegia-associated-Death', 'Death-associated-Paraplegia', 'Thrombocytosis-suggest-Zoonoses', 'Atherosclerosis-correlated-Hematoma', 'Thrombocytosis-associated-Fever', 'Fever-associated-Thrombocytosis', 'Fever-excluded-Zoonoses', 'Fever-excluded-Thrombocytosis', 'Zoonoses-excluded-Thrombocytosis', 'Thrombocytosis-occur-Infections', 'Fever-measure-Malaria', 'Neoplasms-defined-Death', 'Neoplasms-defined-Prostatic Neoplasms', 'Fractures, Bone-contribute-Hyponatremia', 'Fractures, Bone-contribute-Bone Neoplasms', 'Hyponatremia-contribute-Bone Neoplasms', 'Breast Neoplasms-resemble-Neoplasms', 'Syncope, Vasovagal-associated-Bradycardia', 'Bradycardia-associated-Syncope, Vasovagal', 'Hypotension-associated-Bradycardia', 'Bradycardia-associated-Hypotension', 'Syncope-range-Fractures, Bone', 'Alzheimer Disease-characterized-Aneuploidy', 'Atrophy-evaluate-Aneurysm', 'Seizures-defined-Stroke', 'Alzheimer Disease-related-Aneuploidy', 'Status Epilepticus-lead-Death', 'Diabetes Mellitus-associated-Myopia', 'Myopia-associated-Diabetes Mellitus', 'Hemorrhage-result-Cerebral Infarction', 'Hemorrhage-result-Epilepsy', 'Cerebral Infarction-result-Epilepsy', 'Cardiac Output, Low-assess-Genetic Diseases, Inborn', 'Hypertension-treat-Death', 'Cardiac Output, Low-assess-Muscle Weakness', 'Hematoma, Subdural, Chronic-present-Neurologic Manifestations', 'Infarction-account-Amnesia', 'Immunologic Deficiency Syndromes-represent-Pulmonary Disease, Chronic Obstructive', 'Immunologic Deficiency Syndromes-represent-Emphysema', 'Colonic Neoplasms-compare-Neoplasms', 'Brain Injuries-cause-Cerebral Palsy', 'Brain Damage, Chronic-accept-Death', 'Neoplasms-paid-Multiple Organ Failure', 'Neoplasms-paid-Drug-Related Side Effects and Adverse Reactions', 'Neoplasms-paid-Neutropenia', 'Neoplasms-paid-Bone Marrow Diseases', 'Musculoskeletal Diseases-contribute-Clubfoot', 'Pain-contribute-Clubfoot', 'Equinus Deformity-contribute-Lichen Planus', 'Musculoskeletal Diseases-become-Fatigue', 'Musculoskeletal Diseases-become-Muscle Weakness', 'Weight Loss-predict-Carcinoma, Non-Small-Cell Lung', 'Pain-experience-Sleep Initiation and Maintenance Disorders', 'Headache Disorders, Secondary-appear-Hypogonadism', 'Diabetes Mellitus-considered-Hemorrhage', 'Death-evaluate-Tuberculosis', 'Multiple Sclerosis-based-Cold Injury', 'Death-adher-Inflammation', 'Death-caused-Diverticulitis', 'Inflammation-associated-Diverticulitis', 'Diverticulitis-associated-Inflammation', 'Encephalitis-involved-Neurodegenerative Diseases', 'Sensation Disorders-fall-Cardiac Output, Low', 'Sensation Disorders-increase-Hip Fractures', 'Colitis-associated-Immunologic Deficiency Syndromes', 'Immunologic Deficiency Syndromes-associated-Colitis', 'Obesity-associated-Hypertrophy', 'Hypertrophy-associated-Obesity', 'Psychomotor Agitation-accompanied-Alzheimer Disease', 'Inflammation-occur-Tendinopathy', 'Neoplasms-trigger-Heart Arrest', 'Renal Insufficiency, Chronic-defined-Malocclusion', 'Ophthalmoplegia-caused-Multiple Sclerosis', 'Ossification of Posterior Longitudinal Ligament-caused-Multiple Sclerosis', 'Sleep Apnea, Obstructive-appear-Obesity', 'Cerebral Infarction-prevented-Intracranial Hemorrhages', 'Myocardial Infarction-reduce-Peripheral Arterial Disease', 'Hypoxia-cause-Cardiovascular Diseases', 'Hypoxia-cause-Pulmonary Disease, Chronic Obstructive', 'Inflammation-cause-Cardiovascular Diseases', 'Inflammation-cause-Pulmonary Disease, Chronic Obstructive', 'Cardiovascular Diseases-cause-Pulmonary Disease, Chronic Obstructive', 'Lymphoma-involve-Jaw Neoplasms', 'Anophthalmos-associated-Hip Fractures', 'Hip Fractures-associated-Anophthalmos', 'Infections-show-Fractures, Bone', 'Fractures, Bone-build-Pulmonary Atelectasis', 'Neoplasm Metastasis-caused-Carcinoma, Small Cell', 'Stroke, Lacunar-lead-Dementia, Vascular', 'Sepsis-display-Cytomegalovirus Infections', 'Sepsis-display-Neoplasms', 'Sepsis-display-Infections', 'Thrombocytosis-develop-Primary Myelofibrosis', 'Splenomegaly-develop-Primary Myelofibrosis', 'Calcinosis-diagnose-Ischemia', 'Death-shown-Heart Diseases', 'Neurologic Manifestations-caused-Hematoma, Subdural, Acute', 'Blindness-prevent-Glycogen Storage Disease Type II', 'Heart Diseases-lowering-Infections', 'Heart Diseases-delay-Cell Transformation, Viral', 'Myelodysplastic Syndromes-lowering-Infections', 'Myelodysplastic Syndromes-delay-Cell Transformation, Viral', 'Infections-delay-Cell Transformation, Viral', 'Carcinoma, Hepatocellular-compared-Hepatitis C, Chronic', 'Chronic Disease-lose-Death', 'Paralysis-noted-Hypocalcemia', 'Psychomotor Agitation-dilate-Cough', 'Psychomotor Agitation-dilate-Asthma', 'Xerostomia-dilate-Cough', 'Xerostomia-dilate-Asthma', 'Atrophy-exclude-Dementia', 'Sleep Wake Disorders-increase-Cerebrovascular Disorders', 'Restless Legs Syndrome-associated-Cerebrovascular Disorders', 'Cerebrovascular Disorders-associated-Restless Legs Syndrome', 'Sleep Apnea, Obstructive-associated-Cerebrovascular Disorders', 'Cerebrovascular Disorders-associated-Sleep Apnea, Obstructive', 'Pain-used-Musculoskeletal Pain', 'Respiratory Distress Syndrome-complicate-Death', 'Anorexia-related-Infections', 'Anemia-caused-Stomach Neoplasms', 'Diabetes Mellitus-correlated-Hyperopia', 'Cataract-correlated-Hyperopia', 'Neoplasms-cause-Carcinoma', 'Death-comprised-Weight Loss', 'Atherosclerosis-associated-Fatty Liver', 'Fatty Liver-associated-Atherosclerosis', 'Atherosclerosis-associated-Arthritis', 'Arthritis-associated-Atherosclerosis', 'Atherosclerosis-associated-Neoplasms', 'Neoplasms-associated-Atherosclerosis', 'Death-related-Purpura, Thrombocytopenic, Idiopathic', 'Purpura, Thrombocytopenic, Idiopathic-experience-Hemorrhage', 'Hepatitis C-result-Hemophilia A', 'Sleep Wake Disorders-observed-Restless Legs Syndrome', 'Restless Legs Syndrome-observed-Sleep Wake Disorders', 'Olfaction Disorders-related-Alzheimer Disease', 'Ventricular Fibrillation-suffer-Cardiomyopathies', 'Arthritis, Rheumatoid-cause-Pain', 'Necrosis-make-Arthritis, Rheumatoid', 'Inflammation-cause-Pain', 'Mitochondrial Diseases-linked-Nervous System Diseases', 'Prostatic Hyperplasia-describe-Prostatitis', 'Neurocysticercosis-recognised-Epilepsy', 'Macular Degeneration-marked-Death', 'Aortic Diseases-represent-Death', 'Heart Failure-include-Stroke', 'Atrial Fibrillation-include-Heart Failure', 'Atrial Fibrillation-include-Diabetes Mellitus', 'Infections-compared-Central Nervous System Infections', 'Pneumococcal Infections-recommend-Pneumonia', 'Atrial Fibrillation-demonstrate-Death', 'Inflammation-implicated-Atherosclerosis', 'Inflammation-implicated-Hypertension', 'Inflammation-test-Hypertension', 'Inflammation-associate-Atherosclerosis', 'Atherosclerosis-associate-Inflammation', 'Inflammation-test-Cardiovascular Diseases', 'Hypertension-associate-Inflammation', 'Inflammation-associate-Hypertension', 'Peripheral Arterial Disease-found-Hypertension', 'Chronic Pain-defined-Acute Disease', 'Pain-defined-Acute Disease', 'Pain-persist-Acute Disease', 'Fragile X Syndrome-fall-Cardiac Output, Low', 'Apnea-tend-Death', 'Apnea-associated-Death', 'Death-associated-Apnea', 'Sleep Wake Disorders-combined-Hypoxia', 'Death-considered-Anaphylaxis', 'Atrophy-associated-Infarction', 'Infarction-associated-Atrophy', 'Sclerosis-linked-Alzheimer Disease', 'Infarction-identified-Alzheimer Disease', 'Angina Pectoris-associated-Coronary Artery Disease', 'Coronary Artery Disease-associated-Angina Pectoris', 'Angina Pectoris-cause-Death', 'Stroke-addressed-Death', 'Immunologic Deficiency Syndromes-associated-Gastritis', 'Gastritis-associated-Immunologic Deficiency Syndromes', 'Infections-suggest-Nephrotic Syndrome', 'Erectile Dysfunction-associated-Heart Diseases', 'Heart Diseases-associated-Erectile Dysfunction', 'Arthritis, Rheumatoid-compare-Adenomatous Polyposis Coli', 'Vertebrobasilar Insufficiency-complicated-Atherosclerosis', 'Movement Disorders-complicated-Atherosclerosis', 'Ischemia-provoked-Movement Disorders', 'Osteoporotic Fractures-involve-Cardiac Output, Low', 'Hip Fractures-include-Osteoporotic Fractures', 'Urinary Incontinence-report-Stroke', 'Pain-accompanied-Nervous System Diseases', 'Pain-accompanied-Irritable Bowel Syndrome', 'Fibromyalgia-accompanied-Nervous System Diseases', 'Fibromyalgia-accompanied-Irritable Bowel Syndrome', 'Osteoporosis-obtained-Osteoporotic Fractures', 'Asthma-remain-Death', 'Hemophilia A-underlie-Neoplasms', 'Death-followed-Respiratory Tract Infections', 'Cardiovascular Diseases-followed-Neoplasms', 'Cardiovascular Diseases-followed-Respiratory Tract Infections', 'Neoplasms-followed-Respiratory Tract Infections', 'Prostatic Neoplasms-integrated-Neoplasms', 'Prostatic Neoplasms-integrated-Prostatic Hyperplasia', 'Prostatic Neoplasms-focus-Prostatic Hyperplasia', 'Neoplasms-focus-Prostatic Hyperplasia', 'Ventricular Septal Rupture-cause-Hypoxia', 'Pulmonary Valve Stenosis-cause-Hypoxia', 'Hearing Loss-hear-Seizures', 'Atherosclerosis-produce-Retinal Vein Occlusion', 'Infarction-produce-Retinal Vein Occlusion', 'Atrial Fibrillation-link-Heart Failure', 'Atrial Fibrillation-link-Heart Valve Diseases', 'Atrial Fibrillation-link-Hyperthyroidism', 'Genetic Diseases, Inborn-characterized-Cerebellar Ataxia', 'Hemorrhage-seen-Anemia, Iron-Deficiency', 'Anemia, Iron-Deficiency-observed-Ulcer', 'Neoplasms-combined-Death', 'Neoplasms-combined-Lung Neoplasms', 'Colorectal Neoplasms-combined-Death', 'Colorectal Neoplasms-combined-Lung Neoplasms', 'Hypoglycemia-cause-Hyperglycemia', 'Sepsis-rule-Infections', 'Neurologic Manifestations-constitute-Death', 'Atrophy-spread-Alzheimer Disease', 'Pneumonia-continue-Communicable Diseases', 'Heart Diseases-represent-Ischemia', 'Death-remain-Tachycardia', 'Pneumonia-accompany-Emphysema', 'Cystic Fibrosis-increased-Diabetes Mellitus', 'Aortic Valve Stenosis-treat-Primary Ovarian Insufficiency', 'Vascular Calcification-represent-Death', 'Osteoporosis-selected-Osteoporotic Fractures', 'Pain-accept-Neoplasms', 'Fibrosis-attributed-Heart Failure', 'Fibrosis-attributed-Atrial Fibrillation', 'Constipation-experience-Anorexia', 'Constipation-experience-Nausea', 'Constipation-experience-Tooth, Impacted', 'Renal Insufficiency, Chronic-affected-Hyperparathyroidism, Secondary', 'Low Back Pain-calculated-Pain', 'Low Back Pain-calculated-Musculoskeletal Pain', 'Pain-calculated-Musculoskeletal Pain', 'Cardiovascular Diseases-damaging-Hypertension', 'Hypotension-flow-Atherosclerosis', 'Alzheimer Disease-reflect-Brain Damage, Chronic', 'Dementia-proposed-Infarction', 'Cerebral Infarction-proposed-Infarction', 'Cerebral Infarction-proposed-Dementia', 'Cerebral Infarction-follow-Dementia', 'Dementia, Vascular-follow-Cerebral Infarction', 'Femoral Neck Fractures-associated-Osteoporosis', 'Osteoporosis-associated-Femoral Neck Fractures', 'Stroke-improve-Niemann-Pick Disease, Type C', 'Epilepsy-controlled-Seizures', 'Kidney Diseases-characterized-Eye Abnormalities', 'Kidney Diseases-characterized-Hearing Loss, Central', 'Kidney Diseases-characterized-Proteinuria', 'Genetic Diseases, Inborn-characterized-Eye Abnormalities', 'Genetic Diseases, Inborn-characterized-Hearing Loss, Central', 'Genetic Diseases, Inborn-characterized-Proteinuria', 'Tinnitus-descend-Hearing Loss, Central', 'Genetic Diseases, Inborn-descend-Hearing Loss, Central', 'Sleep Wake Disorders-descend-Hearing Loss, Central', 'Hypertension-descend-Hearing Loss, Central', 'Obesity-treated-Cardiovascular Diseases', 'Obesity-treated-Diabetes Mellitus', 'Death-hasten-Heart Diseases', 'Ischemia-result-Coronary Artery Disease', 'Stroke-indicated-Atrial Fibrillation', 'Stroke-indicated-Ventricular Dysfunction', 'Hemorrhage-balance-Thrombosis', 'Hemorrhage-balance-Stroke', 'Bone Neoplasms-intensify-Periodontitis', 'Alzheimer Disease-attributed-Memory Disorders', 'Fanconi Anemia-display-Bone Marrow Failure Disorders', 'Fanconi Anemia-show-Bone Marrow Failure Disorders', 'Fanconi Anemia-demonstrate-Drug Hypersensitivity', 'Pneumonia-include-Pneumococcal Infections', 'Atrophy-affect-Alzheimer Disease', 'Atrial Fibrillation-defined-Myocardial Infarction', 'Atrial Fibrillation-develop-Myocardial Infarction', 'Spinal Injuries-present-Neurodegenerative Diseases', 'Diabetes Mellitus-associated-Memory Disorders', 'Memory Disorders-associated-Diabetes Mellitus', 'Neuromuscular Diseases-contribute-Muscle Weakness', 'Death-show-Liver Failure', 'Deglutition Disorders-show-Malnutrition', 'Glaucoma-include-Retinal Diseases', 'Psychoses, Substance-Induced-worsen-Movement Disorders', 'Parkinsonian Disorders-assess-Psychoses, Substance-Induced', 'Aortic Arch Syndromes-provide-Atherosclerosis', 'Adrenal Insufficiency-contribute-Mitochondrial Diseases', 'Adrenal Insufficiency-contribute-Glucose Intolerance', 'Brain Injuries-account-Wounds and Injuries', 'Fibromyalgia-differentiate-Neurologic Manifestations', 'Sleep Initiation and Maintenance Disorders-result-Nocturia', 'Sleep Initiation and Maintenance Disorders-cause-Nocturia', 'Stroke-predict-Alzheimer Disease', 'Hematoma, Subdural, Chronic-occur-Craniocerebral Trauma', 'Prostatic Neoplasms-define-Neoplasm Metastasis', 'Pancreatitis-remedy-Diabetes Mellitus', 'Carcinoma, Hepatocellular-influence-Death', 'Obesity, Abdominal-increase-Cardiovascular Diseases', 'Cardiac Output, Low-fall-Metabolic Diseases', 'Tuberculosis-related-Lung Diseases', 'Hemoptysis-related-Lung Diseases', 'Adrenal Insufficiency-complicate-Nervous System Diseases', 'Adrenal Insufficiency-progress-Infections', 'Adrenal Insufficiency-progress-Gangrene', 'Hyperoxia-expose-Alzheimer Disease', 'Nervous System Diseases-progress-Infections', 'Nervous System Diseases-progress-Gangrene', 'Ulcer-progress-Infections', 'Ulcer-progress-Gangrene', 'Ulcer-require-Diabetes Mellitus', 'Death-include-Carotid Artery Injuries', 'Cardiovascular Diseases-linked-Atherosclerosis', 'Cardiovascular Diseases-linked-Peripheral Arterial Disease', 'Cardiovascular Diseases-linked-Hypertension', 'Kidney Diseases, Cystic-recognized-Uterine Cervicitis', 'Kidney Diseases, Cystic-recognized-Wounds and Injuries', 'Uterine Cervicitis-recognized-Wounds and Injuries', 'Brain Infarction-predict-Stroke', 'Brain Infarction-predict-Dementia', 'Metabolic Syndrome-associated-Brain Infarction', 'Brain Infarction-associated-Metabolic Syndrome', 'Metabolic Syndrome-used-Stroke', 'Metabolic Syndrome-predict-Stroke', 'Brain Infarction-used-Stroke', 'Myocardial Infarction-associated-Hemorrhage', 'Hemorrhage-associated-Myocardial Infarction', 'Cold Injury-decrease-Signs and Symptoms, Respiratory', 'Parkinson Disease, Secondary-include-Dyskinesia, Drug-Induced', 'Death-established-Rhinitis, Allergic, Seasonal', 'Neoplasm Metastasis-identified-Neoplasms', 'Gait Disorders, Neurologic-increase-Cardiac Output, Low', 'Frailty-increase-Cardiac Output, Low', 'Hepatitis C, Chronic-prevent-Carcinoma, Hepatocellular', 'Neurotoxicity Syndromes-suppress-Neurodegenerative Diseases', 'Alzheimer Disease-described-Diabetes Mellitus', 'Diabetes Mellitus-result-Neurodegenerative Diseases', 'Alzheimer Disease-result-Cerebrovascular Disorders', 'Stroke-result-Cerebrovascular Disorders', 'Heart Diseases-result-Cerebrovascular Disorders', 'Cardiotoxicity-related-Neoplasms', 'Kidney Diseases-account-Hypertension', 'Kidney Diseases-account-Coronary Artery Disease', 'Vision Disorders-cause-Hallucinations', 'Kidney Diseases-found-Renal Insufficiency, Chronic', 'Renal Insufficiency, Chronic-seen-Kidney Diseases', 'Renal Insufficiency, Chronic-include-Cardiomegaly', 'Renal Insufficiency, Chronic-found-Cardiomegaly', 'Neurogenic Inflammation-contribute-Diffuse Neurofibrillary Tangles with Calcification', 'Cardiomegaly-contrast-Kidney Diseases', 'Cardiomegaly-found-Kidney Diseases', 'Retinal Degeneration-contribute-Alzheimer Disease', 'Stomatitis, Denture-increase-Drug-Related Side Effects and Adverse Reactions', 'Lung Neoplasms-increase-Drug-Related Side Effects and Adverse Reactions', 'Infarction-put-Heart Failure', 'Infarction-use-Ischemia', 'Pain-cause-Pain Insensitivity, Congenital', 'Ocular Hypertension-include-Cataract', 'Cataract-treated-Neurodegenerative Diseases', 'Glaucoma-treated-Neurodegenerative Diseases', 'Glaucoma-treated-Corneal Diseases', 'Blindness-treated-Neurodegenerative Diseases', 'Neurodegenerative Diseases-treated-Corneal Diseases', 'Adenocarcinoma-increasing-Neoplasms', 'Infections-include-Adenocarcinoma', 'Puberty, Delayed-characterized-Ataxia', 'Neurodegenerative Diseases-characterized-Ataxia', 'Ataxia-characterized-Nerve Degeneration', 'Ataxia-characterized-Demyelinating Diseases', 'Paralysis-characterized-Nerve Degeneration', 'Paralysis-characterized-Demyelinating Diseases', 'Amyotrophic Lateral Sclerosis-contribute-Neurotoxicity Syndromes', 'Death-notix-Dementia', 'Neurologic Manifestations-lead-Retinal Degeneration', 'Neurologic Manifestations-lead-Vision Disorders', 'Neoplasms-rule-Anemia', 'Breast Neoplasms-determined-Death', 'Breast Neoplasms-performed-Death', 'Leukopenia-develop-Anemia', 'Immunologic Deficiency Syndromes-linked-Renal Insufficiency, Chronic', 'Prostatic Neoplasms-deferred-Neoplasms', 'Coccidioidomycosis-known-Fever', 'Fever-known-Occupational Diseases', 'Peripheral Arterial Disease-give-Death', 'Granuloma-diminish-Inflammation', 'Hypertension-develop-Sleep Wake Disorders', 'Cardiovascular Diseases-develop-Sleep Wake Disorders', 'Cerebrovascular Disorders-develop-Sleep Wake Disorders', 'Sleep Wake Disorders-followed-Sleep Initiation and Maintenance Disorders', 'Sleep Wake Disorders-followed-Sleep Apnea Syndromes', 'Sleep Wake Disorders-followed-Parasomnias', 'Labor Pain-linked-Osteoarthritis', 'Kidney Diseases-decrease-Death', 'Diabetes Mellitus-found-Metabolic Syndrome', 'Pain-report-Polyneuropathies', 'Ischemia-lead-Necrosis', 'Ischemia-lead-Shock', 'Ischemia-accompanied-Acidosis, Lactic', 'Necrosis-result-Shock', 'Necrosis-result-Acidosis, Lactic', 'Necrosis-accompanied-Acidosis, Lactic', 'Shock-accompanied-Acidosis, Lactic', 'Abdominal Pain-experience-Diarrhea', 'Colitis, Ischemic-manifested-Wounds and Injuries', 'Kyphosis-include-Motor Neuron Disease', 'Motor Neuron Disease-measured-Osteoporosis', 'Motor Neuron Disease-measured-Scoliosis', 'Kyphosis-measured-Spinal Fractures', 'Kyphosis-measured-Osteoporosis', 'Kyphosis-measured-Scoliosis', 'Hemorrhage-identify-Death', 'Infections-make-Communicable Diseases', 'Atrophy-maintain-Dementia', 'Thyrotoxicosis-document-Thyroid Diseases', 'Infections-fall-Cardiac Output, Low', 'Infections-fall-Fractures, Bone', 'Infections-fall-Anemia', 'Cardiac Output, Low-fall-Anemia', 'Fractures, Bone-fall-Anemia', 'Renal Insufficiency, Chronic-appear-Death', 'Sleep Disorders, Circadian Rhythm-associated-Cardiac Output, Low', 'Cardiac Output, Low-associated-Sleep Disorders, Circadian Rhythm', 'Sleep Disorders, Circadian Rhythm-fall-Cardiac Output, Low', 'Sleep Disorders, Circadian Rhythm-associated-Dementia', 'Dementia-associated-Sleep Disorders, Circadian Rhythm', 'Diabetes Mellitus-known-Renal Insufficiency, Chronic', 'Kidney Diseases-known-Renal Insufficiency, Chronic', 'Meningeal Neoplasms-analyzed-Ovarian Diseases', 'Neoplasms-underlie-Diabetes Mellitus', 'Coronary Artery Disease-base-Angina Pectoris', 'Cerebral Amyloid Angiopathy-associated-Amyloidosis, Familial', 'Amyloidosis, Familial-associated-Cerebral Amyloid Angiopathy', 'Alzheimer Disease-reproduce-Cerebral Amyloid Angiopathy', 'Communicable Diseases-cause-Cerebral Amyloid Angiopathy', 'Communicable Diseases-cause-Hemorrhage', 'Communicable Diseases-cause-Cerebral Infarction', 'Communicable Diseases-lead-Dementia', 'Cerebral Amyloid Angiopathy-cause-Hemorrhage', 'Cerebral Amyloid Angiopathy-cause-Cerebral Infarction', 'Hemorrhage-lead-Dementia', 'Cystic Fibrosis-increasing-Diabetes Mellitus', 'Neoplasms-emerge-Stomach Neoplasms', 'Neoplasm Metastasis-emerge-Stomach Neoplasms', 'Stroke-result-Hemiplegia', 'Sleep Wake Disorders-correlate-Sleep Initiation and Maintenance Disorders', 'Sleep Apnea Syndromes-related-Heart Failure', 'Ventricular Fibrillation-exhibit-Cartilage Diseases', 'Hypertension-perpetuate-Acute Kidney Injury', 'Intestinal Obstruction-undergo-Cystic Fibrosis', 'Osteoporosis-result-Sarcopenia', 'Pain-provide-Femoral Neck Fractures', 'Hypogonadism-underlie-Breast Neoplasms, Male', 'Osteoporosis-recommended-Cardiac Output, Low', 'Death-recommended-Osteoporosis', 'Hemorrhage-include-Diabetes Mellitus', 'Hemorrhage-include-Osteoarthritis', 'Immunologic Deficiency Syndromes-precede-Muscular Diseases', 'Neoplasms-suggest-Breast Neoplasms', 'Fractures, Bone-assessed-Death', 'Osteoporosis-include-Death', 'Esophageal Squamous Cell Carcinoma-determine-Neoplasms', 'Alzheimer Disease-diagnosed-Neurodegenerative Diseases', 'Neurodegenerative Diseases-diagnosed-Dementia', 'Coinfection-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-Coinfection', 'Infarction-include-Brain Infarction', 'Cerebral Amyloid Angiopathy-associated-Cerebrovascular Disorders', 'Cerebrovascular Disorders-associated-Cerebral Amyloid Angiopathy', 'Acute Disease-recover-Fractures, Bone', 'Pleural Effusion, Malignant-portend-Breast Neoplasms', 'Catastrophic Illness-classified-Acquired Immunodeficiency Syndrome', 'Acute Kidney Injury-tend-Muscle Weakness', 'Central Nervous System Neoplasms-constitute-Hodgkin Disease', 'Hypotension, Orthostatic-associated-Nervous System Diseases', 'Nervous System Diseases-associated-Hypotension, Orthostatic', 'Hypotension, Orthostatic-trigger-Hypertension', 'Hypotension, Orthostatic-trigger-Coronary Artery Disease', 'Hypotension, Orthostatic-trigger-Psychoses, Substance-Induced', 'Hypotension, Orthostatic-trigger-Alzheimer Disease', 'Hypotension, Orthostatic-trigger-Neoplasms', 'Dementia, Vascular-caused-Cerebrovascular Disorders', 'Cerebrovascular Disorders-caused-Dementia, Vascular', 'Heart Failure-perform-Coronary Artery Disease', 'Parkinson Disease-accompanied-Hallucinations', 'Hereditary Breast and Ovarian Cancer Syndrome-linked-Death', 'Death-linked-Diabetes Mellitus', 'Death-linked-Metabolic Syndrome', 'Hypogonadism-reported-Prostatic Neoplasms', 'Hypertension-increase-Heart Failure, Diastolic', 'Death-associated-Pulmonary Fibrosis', 'Pulmonary Fibrosis-associated-Death', 'Apnea-explain-Sleep Apnea, Obstructive', 'Alzheimer Disease-demonstrate-Pain', 'Cardiomyopathy, Hypertrophic-found-Coronary Artery Disease', 'Cardiomyopathy, Hypertrophic-found-Cerebrovascular Disorders', 'Cardiomyopathy, Hypertrophic-found-Peripheral Vascular Diseases', 'Kidney Failure, Chronic-suffer-Death', 'Brain Injuries-associated-Vision Disorders', 'Vision Disorders-associated-Brain Injuries', 'Osteoarthritis-assess-Spinal Osteophytosis', 'Neurodegenerative Diseases-act-Cerebrovascular Disorders', 'Osteoarthritis-reduced-Pain', 'Kidney Failure, Chronic-begin-Renal Insufficiency, Chronic', 'Chronic Disease-delay-Death', 'Chronic Kidney Disease-Mineral and Bone Disorder-increase-Neoplasms', 'Kidney Failure, Chronic-begin-Chronic Kidney Disease-Mineral and Bone Disorder', 'Neoplasms-begin-Renal Insufficiency, Chronic', 'Neoplasms-begin-Chronic Kidney Disease-Mineral and Bone Disorder', 'Infertility, Female-postpon-Obesity', 'Osteoporosis-use-Muscular Dystrophy, Duchenne', 'Neoplasms-followed-Hip Fractures', 'Fractures, Bone-use-Muscular Dystrophy, Duchenne', 'Glaucoma-consider-Blindness', 'Hemochromatosis-predispose-Chondrocalcinosis', 'Hyperparathyroidism-predispose-Chondrocalcinosis', 'Metabolic Diseases-predispose-Chondrocalcinosis', 'Metabolic Diseases-occur-Chondrocalcinosis', 'Xerostomia-identify-Dehydration', 'Osteophyte-seen-Hyperostosis, Diffuse Idiopathic Skeletal', 'Osteoporotic Fractures-imposed-Chronic Disease', 'Osteoporotic Fractures-imposed-Cardiovascular Diseases', 'Osteoporotic Fractures-imposed-Breast Neoplasms', 'Metabolic Diseases-associate-Obesity', 'Obesity-associate-Metabolic Diseases', 'Death-caused-Respiration Disorders', 'Death-caused-Drug-Related Side Effects and Adverse Reactions', 'Memory Disorders-fail-Neurotoxicity Syndromes', 'Neurotoxicity Syndromes-fail-Memory Disorders', 'Neurotoxicity Syndromes-confirm-Memory Disorders', 'Cockayne Syndrome-involve-Growth Disorders', 'Fractures, Stress-cause-Pain', 'Mitochondrial Diseases-play-Cockayne Syndrome', 'Asthma-associate-Arbovirus Infections', 'Arbovirus Infections-associate-Asthma', 'Osteonecrosis-remain-Fractures, Bone', 'Death-diagnose-Diabetes Mellitus', 'Blepharitis-seen-Dry Eye Syndromes', 'Melanoma-reduce-Death', "Hutchinson's Melanotic Freckle-differ-Skin Neoplasms", 'Leukoaraiosis-affect-Cerebral Infarction', 'Peripheral Arterial Disease-experience-Fractures, Bone', 'Ischemia-include-Diabetes Mellitus', 'Ischemia-include-Heart Diseases', 'Cardiovascular Diseases-reported-Erectile Dysfunction', 'Diabetes Mellitus-reported-Erectile Dysfunction', 'Progeria-based-Cardiovascular Diseases', 'Progeria-treated-Coxa Vara', 'Arthritis, Rheumatoid-improve-Necrosis', 'Inflammation-include-Arthritis, Rheumatoid', 'Mitral Valve Insufficiency-assess-Heart Failure', 'Mitral Valve Insufficiency-live-Heart Failure', 'Hypothermia-mandate-Respiratory Insufficiency', 'Myxedema-mandate-Respiratory Insufficiency', 'Respiratory Insufficiency-warrant-Bradycardia', 'Respiratory Insufficiency-warrant-Anemia', 'Respiratory Insufficiency-warrant-Hyponatremia', 'Respiratory Insufficiency-warrant-Pericardial Effusion', 'Dementia-increased-Huntington Disease', 'Atrial Fibrillation-experience-Acute Kidney Injury', 'Nervous System Diseases-recognized-Parkinson Disease, Secondary', 'Parkinson Disease-occur-Hypothermia', 'Weight Loss-accelerate-Sarcopenia', 'Nerve Degeneration-include-Disease Susceptibility', 'Chronic Disease-mitigate-Diabetes Mellitus', 'Chronic Disease-mitigate-Hypertension', 'Wounds and Injuries-show-Leukemia, Lymphoid', 'Calcinosis-examined-Death', 'Cerebral Infarction-examined-Death', 'Calcinosis-associated-Cerebral Infarction', 'Cerebral Infarction-associated-Calcinosis', 'Endocrine System Diseases-associated-Bone Diseases', 'Bone Diseases-associated-Endocrine System Diseases', 'Bone Diseases-indicate-Osteoporosis', 'Hip Fractures-prove-Wounds and Injuries', 'Hearing Loss-supposed-Hearing Loss, Central', 'Idiopathic Pulmonary Fibrosis-make-Lung Neoplasms', 'Syncope-affected-Parkinson Disease', 'Syncope-affected-Heredodegenerative Disorders, Nervous System', 'Jaw, Edentulous-include-Fractures, Bone', 'Parkinson Disease-affected-Fractures, Bone', 'Fractures, Bone-caused-Nervous System Diseases', 'Fractures, Bone-affected-Parkinson Disease', 'Osteoporosis-considered-Parkinson Disease', 'Neoplasms-receive-Death', 'Infections-carry-Death', 'Inflammatory Bowel Diseases-carry-Death', 'Rupture-favor-Thrombosis', 'Colitis-reported-Infections', 'Colitis-reported-Inflammatory Bowel Diseases', 'Neoplasms-examine-Central Nervous System Neoplasms', 'Central Nervous System Neoplasms-examine-Neoplasms', 'Dementia-caused-Atherosclerosis', 'Dementia-caused-Aneurysm', 'Bone Diseases-emerge-Bone Diseases, Metabolic', 'Bone Diseases-become-Osteoporosis', 'Thalassemia-present-Wounds and Injuries', 'Hypotension-established-Diabetes Mellitus', 'Diabetes Mellitus-show-Heart Diseases', 'Diabetes Mellitus-show-Heart Failure, Systolic', 'Muscular Dystrophy, Duchenne-associated-Inflammation', 'Inflammation-associated-Muscular Dystrophy, Duchenne', 'Osteoporosis-increasing-Osteoporotic Fractures', 'Obesity-increase-Heart Diseases', 'Obesity-increase-Sleep Apnea, Obstructive', 'Obesity-increase-Osteoarthritis', 'Pain-include-Mandibular Nerve Injuries', 'Multiple Chronic Conditions-account-Death', 'Hyperalgesia-include-Mandibular Nerve Injuries', 'Cerebrovascular Disorders-account-Death', 'Peripheral Arterial Disease-account-Death', 'Peripheral Arterial Disease-initiate-Renal Insufficiency, Chronic', 'Death-noted-Ischemia', 'Status Epilepticus-present-Death', 'Headache Disorders, Secondary-develop-Dementia', 'Headache Disorders, Secondary-confer-Dementia', 'Neurotoxicity Syndromes-increase-Heredodegenerative Disorders, Nervous System', 'Mitochondrial Diseases-alter-Taste Disorders', 'Foot Ulcer-proposed-Melanoma', 'Xerostomia-correlate-Dry Eye Syndromes', 'Leukemia-include-Death', 'Dementia-undergo-Parkinson Disease', 'Dementia-summarized-Parkinsonian Disorders', 'Dementia-undergo-Parkinsonian Disorders', 'Dementia-herald-Alzheimer Disease', 'Hepatitis C, Chronic-shown-Infections', 'Infections-inhibit-Drug-Related Side Effects and Adverse Reactions', 'Parkinson Disease-occur-Mitochondrial Diseases', 'Parkinson Disease-pre-dispose-Death', 'Aneurysm-worsened-Diabetes Mellitus', 'Urinary Incontinence-followed-Death', 'Respiratory Tract Infections-ranked-Death', 'Kidney Diseases-show-Renal Insufficiency, Chronic', 'Endomyocardial Fibrosis-obtained-Cardiomyopathies', 'Amyloidosis-cause-Cardiomyopathies', 'Chondroblastoma-show-Neoplasm Metastasis', 'Vascular System Injuries-include-Hypotension', 'Chromosome Aberrations-implicated-Neoplasms', 'Pain-accompanied-Edema', 'Anemia-defined-Myelodysplastic Syndromes', 'Aneurysm-repaired-Death', 'Cardiovascular Diseases-contribute-Glucose Metabolism Disorders', 'Scoliosis-noted-Spinal Diseases', 'Adrenal Insufficiency-associated-Atherosclerosis', 'Atherosclerosis-associated-Adrenal Insufficiency', 'Cardiotoxicity-include-Cardiomyopathies', 'Cardiotoxicity-include-Heart Failure', 'Death-associated-Whooping Cough', 'Whooping Cough-associated-Death', 'Fractures, Compression-include-Fractures, Bone', 'Fatigue-include-Fractures, Bone', 'Fractures, Stress-include-Fractures, Bone', 'Death-involve-Vision Disorders', 'Fractures, Spontaneous-occur-Wounds and Injuries', 'Inflammation-resolve-Infections', 'Wounds and Injuries-include-Heart Failure', 'Inflammation-serve-Aneurysm', 'Dementia-found-Obesity', 'Dementia-reduced-Obesity', 'Cross Infection-include-Death', 'Death-identified-Infections', 'Shock-presented-Infections', 'Liver Diseases-associated-Infections', 'Infections-associated-Liver Diseases', 'Glycogen Storage Disease Type II-characterized-Macular Degeneration', 'Diabetes Mellitus-look-Cardiovascular Diseases', 'Migraine Disorders-considered-Stroke', 'Carotid Stenosis-associated-Cerebral Infarction', 'Cerebral Infarction-associated-Carotid Stenosis', 'Carotid Stenosis-relate-Cerebral Infarction', 'Leukoencephalopathies-considered-Cardiovascular Diseases', 'Hypertension-identified-Leukoencephalopathies', 'Psychoses, Substance-Induced-compare-Osteoarthritis', 'Renal Insufficiency-attributed-Drug-Related Side Effects and Adverse Reactions', 'Death-associated-Cholelithiasis', 'Cholelithiasis-associated-Death', 'Infections-suffering-Gastrointestinal Diseases', 'Sensation Disorders-suffering-Gastrointestinal Diseases', 'Muscular Dystrophy, Duchenne-associated-Fractures, Bone', 'Fractures, Bone-associated-Muscular Dystrophy, Duchenne', 'Muscular Dystrophy, Duchenne-calculate-Fractures, Bone', 'Rhabdomyosarcoma-encountered-Fibrosarcoma', 'Hyperkalemia-identified-Kidney Diseases', 'Rhabdomyosarcoma-encountered-Leiomyosarcoma', 'Hyperkalemia-identified-Chemical and Drug Induced Liver Injury', 'Rhabdomyosarcoma-encountered-Liposarcoma', 'Rhabdomyosarcoma-encountered-Histiocytoma, Malignant Fibrous', 'Infections-exceed-Death', 'Atrophy-differentiate-Alzheimer Disease', 'Aneurysm-rated-Atrophy', 'Aneurysm-rated-Dementia', 'Atrophy-rated-Dementia', 'Status Epilepticus-require-Aphasia', 'Pleural Effusion-report-Familial Mediterranean Fever', 'Sepsis-differ-Death', 'Dementia-vary-Alzheimer Disease', 'Sepsis-mirror-Death', 'Heart Failure-investigate-Cerebrovascular Disorders', 'Sleep Wake Disorders-related-Neoplasms', 'Death-occur-Heart Diseases', 'Epilepsy-involve-Seizures', 'Neoplasm Metastasis-undergo-Abdominal Neoplasms', 'Corneal Diseases-estimate-Ocular Hypertension', 'Muscle Rigidity-estimate-Ocular Hypertension', 'Diabetes Mellitus-continue-Liver Cirrhosis', 'Chemical and Drug Induced Liver Injury-refer-Fatty Liver', 'Fibrosis-refer-Fatty Liver', 'Chemical and Drug Induced Liver Injury-range-Fatty Liver', 'Dysarthria-associated-Death', 'Death-associated-Dysarthria', 'Alzheimer Disease-obtained-Stomach Diseases', 'Stomach Diseases-detect-Infections', 'Drug-Related Side Effects and Adverse Reactions-obtained-Neoplasms', 'Weight Loss-suffer-Osteoarthritis, Hip', 'Immunologic Deficiency Syndromes-implicated-Neoplasms', 'Immunologic Deficiency Syndromes-implicated-Osteoporosis', 'Delirium-include-Central Nervous System Diseases', 'Anemia-display-Hypernatremia', 'Hyponatremia-display-Hypernatremia', 'Wounds and Injuries-evolve-Death', 'Death-penetrate-Wounds, Nonpenetrating', 'Wounds and Injuries-penetrate-Wounds, Nonpenetrating', 'Death-follow-Wounds and Injuries', 'Wounds and Injuries-decrease-Wounds, Nonpenetrating', 'Death-decrease-Wounds, Nonpenetrating', 'Renal Insufficiency, Chronic-evolve-Acute Kidney Injury', 'Fractures, Bone-show-Osteoporotic Fractures', 'Death-give-Heart Failure', 'Hemophilia A-protect-Cardiovascular Diseases', 'Coronary Artery Disease-compare-Death', 'Syncope-occur-Bradycardia', 'Urticaria-characterized-Erythema Nodosum', 'Cardiovascular Diseases-result-Hypertension', 'Cardiovascular Diseases-assess-Hypertension', 'Kidney Diseases-account-Renal Insufficiency, Chronic', 'Renal Insufficiency, Chronic-associated-Atherosclerosis', 'Atherosclerosis-associated-Renal Insufficiency, Chronic', 'Renal Insufficiency, Chronic-associated-Drug-Related Side Effects and Adverse Reactions', 'Drug-Related Side Effects and Adverse Reactions-associated-Renal Insufficiency, Chronic', 'Lung Diseases-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-Lung Diseases', 'Hyperthyroidism-occur-Hypothyroidism', 'Pituitary Diseases-cause-Hypopituitarism', 'Pituitary Diseases-detected-Craniocerebral Trauma', 'Hypopituitarism-detected-Craniocerebral Trauma', 'Sleep Wake Disorders-discard-Sleep Initiation and Maintenance Disorders', 'Cholecystitis, Acute-used-Fractures, Open', 'Sepsis-used-Fractures, Open', 'Fractures, Open-used-Death', 'Sleep Initiation and Maintenance Disorders-predispose-Parkinson Disease', 'Drug Eruptions-mimic-Cutaneous Fistula', 'Cleft Palate-include-Abnormalities, Drug-Induced', 'Craniofacial Abnormalities-lead-Bone Diseases, Metabolic', 'Atrophy-show-Heart Failure', 'Stroke-prove-Obesity', 'Stroke-prove-Coronary Artery Disease', 'Williams Syndrome-use-Death', 'Obesity-underrate-Coronary Artery Disease', 'Williams Syndrome-select-Death', 'Heart Failure-include-Cerebrovascular Disorders', 'Heart Failure-include-Alzheimer Disease', 'Epilepsy-remain-Seizures', 'Seizures-remain-Drug-Related Side Effects and Adverse Reactions', 'Cataract-cause-Blindness', 'Dehydration-increase-Infections', 'Neoplasms-hospitalized-Sarcoidosis', 'Neoplasms-compare-Sarcoidosis', 'Heart Diseases-associated-Joint Diseases', 'Joint Diseases-associated-Heart Diseases', 'Ochronosis-develop-Aortic Valve Stenosis', 'Neurologic Manifestations-contribute-Alzheimer Disease', 'Muscle Hypertonia-seen-Polyuria', 'Wounds and Injuries-associated-Tetany', 'Tetany-associated-Wounds and Injuries', 'Stroke-stratify-Ischemia', 'Alzheimer Disease-comprise-Memory Disorders', 'Malformations of Cortical Development-explain-Hemorrhage', 'Atherosclerosis-cause-Coronary Artery Disease', 'Atherosclerosis-cause-Erectile Dysfunction', 'Osteosarcoma-embedded-Bone Neoplasms', 'Blind Loop Syndrome-evaluate-Malabsorption Syndromes', 'Irritable Bowel Syndrome-referred-Diarrhea', 'Death-observed-Seizures', 'Kidney Failure, Chronic-affect-Heart Failure', 'Kidney Failure, Chronic-affect-Diabetes Mellitus', 'Kidney Failure, Chronic-affect-Lung Diseases', 'Kidney Failure, Chronic-affect-Arthritis', 'Kidney Failure, Chronic-affect-Neoplasms', 'Dementia-halt-Neurodegenerative Diseases', 'Diabetes Mellitus-associated-Liver Cirrhosis', 'Liver Cirrhosis-associated-Diabetes Mellitus', 'Urinary Bladder, Overactive-noted-Kidney Diseases', 'Urinary Bladder, Overactive-reduce-Urinary Incontinence', 'Rosacea-associated-Dry Eye Syndromes', 'Dry Eye Syndromes-associated-Rosacea', 'Death-develop-Chemical and Drug Induced Liver Injury', 'Death-observed-Angina, Unstable', 'Peptic Ulcer-contribute-Gastrointestinal Hemorrhage', 'Hemorrhage-contribute-Gastrointestinal Hemorrhage', 'Parkinson Disease-confirmed-Death', 'Infections-preexist-Coronary Artery Disease', 'Infections-observed-Neoplasms', 'Infections-observed-Kidney Neoplasms', 'Diabetes Mellitus-blunted-Hypoxia', 'Atrial Fibrillation-cause-Tachycardia', 'Atrial Fibrillation-associated-Tachycardia', 'Tachycardia-associated-Atrial Fibrillation', 'Sarcopenia-reverse-Muscular Diseases', 'Xeroderma Pigmentosum-associated-Skin Neoplasms', 'Skin Neoplasms-associated-Xeroderma Pigmentosum', 'Kartagener Syndrome-attenuated-Neoplasms', 'Hypogonadism-result-Gonadal Disorders', 'Hemorrhage-registered-Neoplasms', 'Infections-lead-Pneumonia', 'Myocardial Infarction-observe-Hypercholesterolemia', 'Myocardial Infarction-observe-Cerebral Infarction', 'Erectile Dysfunction-shown-Cardiovascular Diseases', 'Erectile Dysfunction-shown-Hypertension', 'Erectile Dysfunction-shown-Obesity', 'Bone Marrow Diseases-include-Multiple Myeloma', 'Meibomian Gland Dysfunction-recognized-Dry Eye Syndromes', 'Death-caused-Breast Neoplasms', 'Gastrointestinal Hemorrhage-characterized-Thrombocytopenia', 'Anemia, Aplastic-characterized-Thrombocytopenia', 'Thrombocytopenia-caused-Bone Marrow Diseases', 'Bone Marrow Diseases-caused-Hemorrhage', 'Anemia, Aplastic-include-Gastrointestinal Hemorrhage', 'Hemorrhage-include-Gastrointestinal Hemorrhage', 'Anemia, Aplastic-include-Hemorrhage', 'Lupus Erythematosus, Systemic-diagnosed-Lymphohistiocytosis, Hemophagocytic', 'Lymphohistiocytosis, Hemophagocytic-diagnosed-Arthritis, Rheumatoid', 'Hashimoto Disease-include-Autoimmune Diseases', 'Lymphohistiocytosis, Hemophagocytic-diagnosed-Autoimmune Diseases', 'Autoimmune Pancreatitis-include-Autoimmune Diseases', 'Arthritis, Rheumatoid-diagnosed-Autoimmune Diseases', 'Death-type-Osteoporosis', 'Death-type-Metabolic Syndrome', 'Atrial Fibrillation-result-Chest Pain', 'Atrial Fibrillation-result-Heart Failure', 'Neurodegenerative Diseases-carry-Death', 'Gallstones-confirmed-Coronary Artery Disease', 'Diabetes Mellitus-confirmed-Coronary Artery Disease', 'Peripheral Arterial Disease-improve-Death', 'Cardiovascular Diseases-experience-Peripheral Arterial Disease', 'Stroke-experience-Peripheral Arterial Disease', 'Sleep Initiation and Maintenance Disorders-reported-Wounds and Injuries', 'Hypertension-control-Coronary Artery Disease', 'Brain Injuries, Traumatic-known-Amnesia, Retrograde', 'Metabolic Syndrome-based-Diabetes Mellitus', 'Oculocerebrorenal Syndrome-associated-Dementia', 'Dementia-associated-Oculocerebrorenal Syndrome', 'Dementia-detected-Oculocerebrorenal Syndrome', 'Anorexia-base-Cachexia', 'Sarcopenia-base-Cachexia', 'Muscular Atrophy-counteract-Cachexia', 'Muscular Atrophy-counteract-Wounds and Injuries', 'Inflammation-suggest-Diabetes Mellitus', 'Atrial Fibrillation-raise-Cerebral Infarction', 'Cerebral Infarction-raise-Atrial Fibrillation', 'Sepsis-underlie-Death', 'Hypokalemia-precipitated-Drug Overdose', 'Infections-associate-Death', 'Death-associate-Infections', 'Skin Abnormalities-manifest-Ichthyosis', 'Ichthyosis-manifest-Atrophy', 'Kyphosis-include-Growth Disorders', 'Cachexia-include-Growth Disorders', 'Death-include-Growth Disorders', 'Infections-show-Respiratory Insufficiency', 'Death-induce-Infections', 'Immunologic Deficiency Syndromes-represent-Genetic Diseases, Inborn', 'Immunologic Deficiency Syndromes-known-Ataxia Telangiectasia', 'X-Linked Combined Immunodeficiency Diseases-represent-Genetic Diseases, Inborn', 'X-Linked Combined Immunodeficiency Diseases-known-Ataxia Telangiectasia', 'X-Linked Combined Immunodeficiency Diseases-described-Immunologic Deficiency Syndromes', 'Anemia-concern-Chronic Disease', 'Anemia-caused-Chronic Disease', 'Shock, Septic-need-Respiratory Insufficiency', 'Shock, Septic-develop-Myocardial Infarction', 'Respiratory Insufficiency-develop-Myocardial Infarction', 'Neoplasms-inform-Neurodegenerative Diseases', 'Infarction-treated-Diabetes Mellitus', 'Dementia-observe-Diabetes Mellitus', 'Dementia-treated-Diabetes Mellitus', 'Fractures, Bone-stabilized-Sarcoma, Clear Cell', 'Oculocerebrorenal Syndrome-followed-Fractures, Bone', 'Pneumonia-described-Emphysema', 'Sotos Syndrome-rescue-Neurodegenerative Diseases', 'Dementia-proven-Diabetes Mellitus', 'Diabetes Mellitus-develop-Leukoaraiosis', 'Drug Hypersensitivity-associated-Fecal Incontinence', 'Fecal Incontinence-associated-Drug Hypersensitivity', 'Fatigue-report-Inflammation', 'Fatigue-prevent-Inflammation', 'HIV Infections-transformed-Chronic Disease', 'Inflammation-play-Insomnia, Fatal Familial', 'Urolithiasis-associated-Prostatic Neoplasms', 'Prostatic Neoplasms-associated-Urolithiasis', 'Cartilage Diseases-cause-Pain', 'Carcinoma, Merkel Cell-affect-Prostatic Neoplasms', 'Prostatic Neoplasms-exhibit-Inflammation', 'Substance-Related Disorders-receive-Death', 'Aneurysm-associated-Alzheimer Disease', 'Alzheimer Disease-associated-Aneurysm', 'Alzheimer Disease-compare-Myotonic Dystrophy', 'Dementia-compared-Myotonic Dystrophy', 'Dementia, Vascular-compare-Myotonic Dystrophy', 'Fibromuscular Dysplasia-occur-Hypertension', 'Fibromuscular Dysplasia-present-Hypertension', 'Fibromuscular Dysplasia-included-Hypertension', 'Albuminuria-mediate-Death', 'Albuminuria-retain-Death', 'Albuminuria-select-Death', 'Albuminuria-confirm-Death', 'Chiari-Frommel Syndrome-lead-Hearing Loss', 'Chiari-Frommel Syndrome-underlie-Otosclerosis', 'Retinal Vein Occlusion-associated-Thrombophilia', 'Thrombophilia-associated-Retinal Vein Occlusion', 'Retinal Vein Occlusion-associated-Blood Coagulation Disorders, Inherited', 'Blood Coagulation Disorders, Inherited-associated-Retinal Vein Occlusion', 'Medulloblastoma-overlap-Leukemia, Lymphocytic, Chronic, B-Cell', 'Aneurysm-appear-Alzheimer Disease', 'Aneurysm-appear-Hypertension', 'Aneurysm-appear-Metabolic Syndrome', 'Alzheimer Disease-reduce-Hypertension', 'Alzheimer Disease-reduce-Metabolic Syndrome', 'Asthma-increase-Death', 'Asthma-perceive-Airway Obstruction', 'Headache Disorders, Secondary-compare-Diabetes Mellitus', 'Hip Fractures-included-Fractures, Bone', 'Death-study-Muscular Dystrophy, Duchenne', 'Death-study-Osteoporotic Fractures', 'Muscle Rigidity-caused-Heart Failure', 'Atrial Fibrillation-caused-Heart Failure', 'Death-predict-Muscular Dystrophy, Duchenne', 'Death-predict-Osteoporotic Fractures', 'Infections-occur-Necrosis', 'Sleep Initiation and Maintenance Disorders-focus-Urinary Incontinence', 'Death-identified-Colonic Neoplasms', 'Death-listed-Multiple Myeloma', 'Signs and Symptoms, Respiratory-confirm-Lung Abscess', 'Periodontitis-underlie-Periodontal Diseases', 'Carcinoma, Lobular-show-Neoplasms', 'Diabetes Mellitus-implicate-Hypotension', 'Liver Cirrhosis-diagnosed-Carcinoma, Hepatocellular', 'Renal Insufficiency, Chronic-associated-Aneurysm', 'Aneurysm-associated-Renal Insufficiency, Chronic', 'Acute Kidney Injury-decline-HIV Infections', 'Dementia-remain-Delirium', 'Hypoalbuminemia-include-Delirium', 'Arthritis, Rheumatoid-find-Hypothyroidism', 'Ischemia-salvage-Critical Illness', 'Ovarian Neoplasms-experience-Parkinson Disease, Secondary', 'Infarction-salvage-Critical Illness', 'Hemorrhage-associated-Bradycardia', 'Bradycardia-associated-Hemorrhage', 'Peritoneal Neoplasms-related-Neoplasms', 'Meningeal Neoplasms-cause-Death', 'Meningeal Neoplasms-present-Radiculopathy', 'Hypothyroidism-suffer-Kidney Diseases', 'Skin Diseases-decrease-Skin Neoplasms', 'Renal Insufficiency-suffer-Kidney Diseases', 'Kidney Failure, Chronic-suffer-Kidney Diseases', 'Stroke-identify-Death', 'Myocardial Infarction-identify-Death', 'Pulmonary Disease, Chronic Obstructive-identify-Death', 'Atrial Fibrillation-identify-Death', 'Urinary Bladder, Neurogenic-include-Alzheimer Disease', 'Cerebral Amyloid Angiopathy-include-Alzheimer Disease', 'Cardiovascular Diseases-decrease-Dementia', 'Machado-Joseph Disease-use-HIV Infections', 'Hepatitis C, Chronic-progress-Fibrosis', 'Hepatitis C, Chronic-develop-Carcinoma, Hepatocellular', 'Infections-develop-Carcinoma, Hepatocellular', 'Heart Failure-occur-Hypertension', 'Heart Failure-occur-Heart Valve Diseases', 'Heart Failure-occur-Diabetes Mellitus', 'Heart Failure-occur-Hypertrophy', 'Heart Failure-occur-Cardiomyopathies', 'Heart Valve Diseases-enhanced-Hypertension', 'Atrophy-develop-Fibrosis', 'Fibrosis-lead-Sarcopenia', 'Neurotoxicity Syndromes-hypothesized-Alzheimer Disease', 'Skin Neoplasms-detected-Neoplasms', 'Sensation Disorders-associated-Cardiac Output, Low', 'Cardiac Output, Low-associated-Sensation Disorders', 'Parkinson Disease-rescue-Neurodegenerative Diseases', 'Neoplasms-represent-Heart Arrest', 'Cardiovascular Diseases-overestimate-Neoplasms', 'Alcoholism-include-Death', 'Hypertension-play-Atrial Fibrillation', 'Coronary Artery Disease-play-Atrial Fibrillation', 'Inflammation-play-Atrial Fibrillation', 'Atrial Remodeling-prevent-Atrial Fibrillation', 'Neoplasms-surpass-Heart Diseases', 'Heart Diseases-underlie-Atrial Fibrillation', 'Death-surpass-Heart Diseases', 'Diarrhea-occur-Anemia', 'Weight Loss-occur-Anemia', 'Brain Damage, Chronic-seem-Pain', 'Pain-cause-Brain Damage, Chronic', 'Obesity-related-Arthritis', 'Obesity-appear-Arthritis', 'Obesity-function-Heart Diseases', 'Obesity-function-Arthritis', 'Heart Diseases-function-Arthritis', 'Heart Diseases-function-Diabetes Mellitus', 'Arthritis-function-Diabetes Mellitus', 'Hypothalamic Neoplasms-shown-Coronary Artery Disease', 'Hypothalamic Neoplasms-assess-Cardiovascular Diseases', 'Hypothalamic Neoplasms-assess-Coronary Artery Disease', 'Hypothalamic Neoplasms-assess-Death', 'Kidney Tubular Necrosis, Acute-use-Renal Insufficiency, Chronic', 'Inflammation-increase-Arthritis', 'Inflammation-associated-Neurotoxicity Syndromes', 'Neurotoxicity Syndromes-associated-Inflammation', 'Arthritis, Rheumatoid-associated-Arthralgia', 'Arthralgia-associated-Arthritis, Rheumatoid', 'Psychoses, Substance-Induced-include-Delirium', 'Infections-seen-Venous Thrombosis', 'Blindness-increase-Alzheimer Disease', 'Diabetes Mellitus-reduce-Skin Diseases', 'Prostatic Neoplasms-contribute-Death', 'Infections-control-Communicable Diseases', 'Dementia-assess-Alzheimer Disease', 'Glaucoma-enucleated-Wounds and Injuries', 'Neoplastic Syndromes, Hereditary-acquire-Adenomatous Polyposis Coli', 'Adenomatous Polyposis Coli-acquire-Infections', 'Neurodegenerative Diseases-contribute-Neoplasms', 'Dementia-suffer-Hip Fractures', 'Heart Failure-increase-Hip Fractures', 'Pulmonary Disease, Chronic Obstructive-increase-Hip Fractures', 'Neoplasms-increase-Hip Fractures', 'Death-estimated-Stroke', 'Death-estimated-Ischemia', 'Death-estimated-Cerebral Hemorrhage', 'Death-estimated-Subarachnoid Hemorrhage', 'Death-associated-Unconsciousness', 'Unconsciousness-associated-Death', 'Obesity-recommend-Weight Loss', 'Urinary Incontinence, Stress-reduce-Seizures', 'Diabetes Mellitus-reduce-Seizures', 'Heart Arrest-reduce-Seizures', 'Coronary Artery Disease-calibrate-Death', 'Sleep Initiation and Maintenance Disorders-associated-Diurnal Enuresis', 'Diurnal Enuresis-associated-Sleep Initiation and Maintenance Disorders', 'Inflammation-involved-Virilism', 'Osteoarthritis-compared-Atherosclerosis', 'Leukoencephalopathies-modulate-Alzheimer Disease', 'Neoplasms-predispose-Osteoporosis', 'Hypogonadism-associated-Neoplasms', 'Neoplasms-associated-Hypogonadism', 'Neoplasms-associated-Fractures, Bone', 'Fractures, Bone-associated-Neoplasms', 'Ovarian Neoplasms-include-Drug-Related Side Effects and Adverse Reactions', 'Ovarian Neoplasms-predict-Drug-Related Side Effects and Adverse Reactions', 'Death-caused-Respiratory Tract Diseases', 'Stroke-include-Myocardial Infarction', 'Stroke-include-Heart Defects, Congenital', 'Stroke-include-Foramen Ovale, Patent', 'Craniocerebral Trauma-included-Subarachnoid Hemorrhage', 'Craniocerebral Trauma-included-Hematoma, Subdural', 'Stroke-include-Plaque, Atherosclerotic', 'Stroke-include-Heart Valve Diseases', 'Stroke-include-Endocarditis', 'Obesity-play-Osteoarthritis', 'Hypertension-increase-Sleep Apnea Syndromes', 'Hypertension-increase-Renal Insufficiency, Chronic', 'Weight Loss-treat-Hypertension', 'Obesity-treat-Hypertension', 'Wounds and Injuries-collected-Tooth Injuries', 'Osteoporosis-account-Fractures, Bone', 'Hip Fractures-used-Osteoporosis', 'Hip Fractures-diagnose-Osteoporosis', 'Cerebrovascular Disorders-recognized-Dementia', 'Cerebrovascular Disorders-associated-Subarachnoid Hemorrhage', 'Subarachnoid Hemorrhage-associated-Cerebrovascular Disorders', 'Turner Syndrome-associated-Hypogonadism', 'Hypogonadism-associated-Turner Syndrome', 'Turner Syndrome-associated-Osteoporosis', 'Osteoporosis-associated-Turner Syndrome', 'Colorectal Neoplasms-associated-Weight Loss', 'Weight Loss-associated-Colorectal Neoplasms', 'Turner Syndrome-considered-Fractures, Bone', 'Turner Syndrome-associated-Fractures, Bone', 'Fractures, Bone-associated-Turner Syndrome', 'Fractures, Bone-done-Turner Syndrome', 'Pain-relate-Chronic Pain', 'Pulmonary Disease, Chronic Obstructive-develop-Chronic Disease', 'Nephritis, Hereditary-caused-Hearing Loss, Central', 'Death, Sudden-accelerate-Atherosclerosis', 'Anemia-associated-Malabsorption Syndromes', 'Malabsorption Syndromes-associated-Anemia', 'Immunologic Deficiency Syndromes-associated-Anemia', 'Anemia-associated-Immunologic Deficiency Syndromes', 'Immunologic Deficiency Syndromes-associated-Malabsorption Syndromes', 'Malabsorption Syndromes-associated-Immunologic Deficiency Syndromes', 'Headache-suspected-Malignant Hyperthermia', 'Malignant Hyperthermia-seen-Hypercapnia', 'Malignant Hyperthermia-seen-Fever', 'Thyroid Diseases-noted-Hypothyroidism', 'Respiratory Tract Infections-associated-Asthma', 'Asthma-associated-Respiratory Tract Infections', 'Respiratory Tract Infections-report-Lung Diseases', 'Leukemia-cover-Leukemia, Myeloid, Acute', 'Leukemia-cover-Leukemia, Promyelocytic, Acute', 'Intervertebral Disc Degeneration-reduce-Back Pain', 'Cerebral Amyloid Angiopathy-result-Nerve Degeneration', 'Cerebral Amyloid Angiopathy-contribute-Nerve Degeneration', 'Cerebral Amyloid Angiopathy-result-Dementia', 'Death-inhibit-Shock', 'Wounds and Injuries-inhibit-Shock', 'Myelodysplastic Syndromes-gain-Anemia', 'Myelodysplastic Syndromes-considered-Neoplasms', 'Venous Thrombosis-present-Adrenocortical Carcinoma', 'Heart Failure, Diastolic-occur-Hypertension', 'Heart Failure, Diastolic-occur-Diabetes Mellitus', 'Heart Failure, Diastolic-associated-Obesity', 'Obesity-associated-Heart Failure, Diastolic', 'Heart Failure, Diastolic-estimated-Heart Failure', 'Inflammation-play-Coronary Artery Disease', 'Renal Insufficiency-treated-Kidney Diseases', 'Renal Insufficiency-necessitate-Kidney Diseases', 'Dementia-develop-Hydrocephalus', 'Renal Insufficiency-demonstrate-Kidney Diseases', 'Leukemia, Myelogenous, Chronic, BCR-ABL Positive-followed-Leukemia, Lymphocytic, Chronic, B-Cell', 'Leukemia, Myelogenous, Chronic, BCR-ABL Positive-develop-Leukemia, Lymphocytic, Chronic, B-Cell', 'Osteoarthritis-compare-Hip Dislocation, Congenital', 'Colorectal Neoplasms-occur-Microsatellite Instability', 'Neoplasms-lead-Heart Arrest', 'Aneurysm, Ruptured-happen-Stroke', 'Subarachnoid Hemorrhage-happen-Stroke', 'Polydipsia-increased-Death', 'Neoplasms-attributed-Infections', 'Heart Diseases-implicated-Cardiovascular Diseases', 'Heart Diseases-implicated-Death, Sudden', 'Heart Failure-screened-Osteoporosis', 'Heart Failure-increase-Fractures, Bone', 'Death-related-Cerebrovascular Disorders', 'Coronary Artery Disease-become-Hemophilia A', 'Heart Valve Diseases-become-Hemophilia A', 'Optic Neuropathy, Ischemic-characterised-Vision Disorders', 'Optic Nerve Diseases-characterised-Vision Disorders', 'Urinary Bladder, Overactive-defined-Nocturia', 'Cardiomyopathy, Hypertrophic-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-Cardiomyopathy, Hypertrophic', 'Osteoporotic Fractures-affected-Uterine Cervicitis', 'Rheumatic Heart Disease-associated-Death', 'Death-associated-Rheumatic Heart Disease', 'Autoimmune Diseases-include-Aneurysm', 'Polymyositis-include-Aneurysm', 'Myasthenia Gravis-include-Aneurysm', 'Arthritis, Rheumatoid-include-Aneurysm', 'Glucose Metabolism Disorders-play-Aortic Diseases', 'Pulmonary Disease, Chronic Obstructive-reveal-Death', 'Ischemia-prevent-Coronary Artery Disease', 'Melanoma-identified-Neoplasms', 'Drug-Related Side Effects and Adverse Reactions-treat-Central Nervous System Neoplasms', 'Stroke-confirm-Ischemia', 'Meningeal Neoplasms-undergo-Neoplasms', 'Dyskinesia, Drug-Induced-triggered-Fatigue', 'Atherosclerosis-associated-Heart Septal Defects, Atrial', 'Heart Septal Defects, Atrial-associated-Atherosclerosis', 'Hypertension-become-Dyspnea', 'Hypertension-become-Cyanosis', 'Pain-include-Diabetes Mellitus', 'Pain Insensitivity, Congenital-assessed-Pain', 'Diabetes Mellitus-associated-Diverticular Diseases', 'Diverticular Diseases-associated-Diabetes Mellitus', 'Coronary Artery Disease-associated-Diverticular Diseases', 'Diverticular Diseases-associated-Coronary Artery Disease', 'Renal Insufficiency-increasing-Uremia', 'Infertility, Female-face-Neoplasms', 'Metabolism, Inborn Errors-result-Death', 'Metabolic Syndrome-exert-Thrombosis', 'Myelodysplastic Syndromes-represent-Leukemia, Myeloid', 'Acquired Immunodeficiency Syndrome-include-Chronic Disease', 'Dementia-linked-Death', 'Acquired Immunodeficiency Syndrome-diagnosed-Death', 'Leukemia, Myeloid, Acute-emerge-Myelodysplastic Syndromes', 'Neoplasm Metastasis-represent-Neoplasms', 'Leukemia, Lymphocytic, Chronic, B-Cell-characterized-Pancytopenia', 'Leukemia, Lymphocytic, Chronic, B-Cell-characterized-Bone Marrow Diseases', 'Neoplasms-characterized-Pancytopenia', 'Neoplasms-characterized-Bone Marrow Diseases', 'Anemia, Aplastic-characterized-Pancytopenia', 'Anemia, Aplastic-characterized-Bone Marrow Diseases', 'Hematologic Diseases-characterized-Pancytopenia', 'Hematologic Diseases-characterized-Bone Marrow Diseases', 'Coronary Artery Disease-cause-Malnutrition', 'Renal Insufficiency, Chronic-cause-Malnutrition', 'Renal Insufficiency, Chronic-divided-Coronary Artery Disease', 'Obesity-use-Renal Insufficiency, Chronic', 'Carotid Artery Diseases-give-Constriction, Pathologic', 'Osteoporosis-compromised-Diabetes Mellitus', 'Neurologic Manifestations-increase-Hypertension', 'Cataract-follow-Corneal Opacity', 'Wounds and Injuries-associated-Brain Injuries, Traumatic', 'Brain Injuries, Traumatic-associated-Wounds and Injuries', 'Heart Failure-tend-Immunologic Deficiency Syndromes', 'Herpes Zoster-associate-Death', 'Death-associate-Herpes Zoster', 'Herpes Zoster-associate-Infections', 'Infections-associate-Herpes Zoster', 'Thromboembolism-compared-Hemorrhage', 'Hip Fractures-compare-Pain', 'Hip Fractures-compare-Femoral Neck Fractures', 'Pain-compare-Femoral Neck Fractures', 'Tuberculosis, Pulmonary-include-Communicable Diseases', 'Pneumonia-include-Communicable Diseases', 'Pulmonary Disease, Chronic Obstructive-include-Communicable Diseases', 'Gastroenteritis-include-Communicable Diseases', 'Fever-include-Communicable Diseases', 'Tetany-include-Communicable Diseases', 'Hypoalbuminemia-found-Respiratory Tract Infections', 'Obesity-decrease-Breast Neoplasms', 'Death-yield-Fractures, Bone', 'Fatigue-seem-Substance-Related Disorders', 'HIV Infections-made-Acquired Immunodeficiency Syndrome', 'Infections-cause-Respiratory Tract Infections', 'Death-caused-Respiratory Tract Infections', 'Intracranial Aneurysm-depend-Aneurysm', 'Intracranial Aneurysm-include-Pain', 'Cancer Pain-result-Neoplasms', 'Cancer Pain-induce-Airway Obstruction', 'Neoplasms-result-Visceral Pain', 'Visceral Pain-induce-Airway Obstruction', 'Hepatitis-presented-Pain', 'Pain-range-Neoplasms', 'Cancer Pain-describe-Sensation Disorders', 'Constipation-associated-Pain', 'Pain-associated-Constipation', 'Hemorrhage-account-Angiodysplasia', 'Hemorrhage-account-Postpartum Hemorrhage', 'Angiodysplasia-account-Postpartum Hemorrhage', 'Alzheimer Disease-increase-Obesity, Abdominal', 'Arthritis-attenuate-Pain', 'Fractures, Bone-sustain-Death', 'Death-induced-Prostatic Neoplasms', 'Atrial Fibrillation-include-Inflammation', 'Hypertension-treated-Alagille Syndrome', 'Venous Thromboembolism-detected-Thrombosis', 'Cardiovascular Diseases-restrict-Heart Failure', 'Death-caused-Intestinal Diseases', 'Death-caused-Noncommunicable Diseases', 'Intestinal Diseases-associated-Infections', 'Infections-associated-Intestinal Diseases', 'Infections-caused-Noncommunicable Diseases', 'Renal Artery Obstruction-associated-Hypertension', 'Hypertension-associated-Renal Artery Obstruction', 'Renal Artery Obstruction-associated-Kidney Diseases', 'Kidney Diseases-associated-Renal Artery Obstruction', 'Renal Artery Obstruction-associated-Heart Failure', 'Heart Failure-associated-Renal Artery Obstruction', 'Renal Artery Obstruction-associated-Angina Pectoris', 'Angina Pectoris-associated-Renal Artery Obstruction', 'Fractures, Bone-reduced-Neoplasms', 'Common Cold-associated-Hypertension', 'Hypertension-associated-Common Cold', 'Common Cold-associated-Kidney Diseases', 'Kidney Diseases-associated-Common Cold', 'Common Cold-associated-Heart Failure', 'Heart Failure-associated-Common Cold', 'Common Cold-associated-Angina Pectoris', 'Angina Pectoris-associated-Common Cold', 'Lymphoma, Non-Hodgkin-increase-Skin Neoplasms', 'Neoplasms-become-Thrombosis', 'Dystonia-superimposed-Muscle Hypotonia', 'Dystonia-associated-Hypokinesia', 'Hypokinesia-associated-Dystonia', 'Fibrosis-indicated-Liver Failure', 'Carcinoma, Hepatocellular-indicated-Liver Failure', 'Alzheimer Disease-develop-Amyloidosis', 'Sensation Disorders-affected-Poliomyelitis', 'Vision Disorders-use-Cataract', 'Dementia-diagnosed-Nervous System Diseases', 'Aneurysm-compared-Varicose Ulcer', 'Aneurysm-randomly-Varicose Ulcer', 'Werner Syndrome-needed-Neoplasms', 'Genetic Diseases, Inborn-needed-Neoplasms', 'Anemia-increase-Thromboembolism', 'Neoplasms-increase-Thromboembolism', 'Hepatitis B, Chronic-lead-Cardiac Complexes, Premature', 'Hepatitis B, Chronic-lead-Liver Cirrhosis', 'Hepatitis, Viral, Human-declining-Infections', 'Renal Insufficiency-treated-Hepatitis C, Chronic', 'Hepatitis B-directed-Infections', 'Hepatitis B-become-Infections', 'Chemical and Drug Induced Liver Injury-include-Hepatitis C', 'Neoplasms-found-Pain', 'Fractures, Stress-found-Fractures, Bone', 'Fractures, Stress-associated-Neoplasms', 'Neoplasms-associated-Fractures, Stress', 'Pneumonia-base-Respiratory Tract Infections', 'Respiratory Tract Infections-hospitalized-Pneumonia', 'Parkinson Disease-doubled-Diabetes Mellitus, Type 2', 'Parkinson Disease-extend-Mitochondrial Diseases', 'Hypoglycemia-include-Diabetes Mellitus', 'Sprains and Strains-prevent-Necrosis', 'Lymphocytosis-raise-Neoplasms', 'Urinary Incontinence-related-Muscle Hypertonia', 'Craniocerebral Trauma-include-Delirium', 'Obesity-develop-Pain', 'Inflammation-overlap-Atherosclerosis', 'Dementia-related-Sarcopenia', 'Osteoporosis-position-Fractures, Bone', 'Fecal Incontinence-followed-Paralysis', 'Death-identify-Chronic Disease', 'Seizures-include-Cerebrovascular Disorders', 'Seizures-include-Dementia', 'Seizures-include-Craniocerebral Trauma', 'Seizures-include-Brain Diseases, Metabolic', 'Sleep Apnea, Obstructive-considered-Hypoxia', 'Sleep Apnea, Obstructive-considered-Obesity', 'Sleep Apnea, Obstructive-considered-Respiratory Insufficiency', 'Hypoxia-considered-Respiratory Insufficiency', 'Obesity-considered-Respiratory Insufficiency', 'Osteoporosis-increase-Hip Fractures', 'Bone Diseases, Metabolic-increase-Hip Fractures', 'Aortic Aneurysm, Abdominal-weigh-Aneurysm, Ruptured', 'Pain-experienced-Neoplasms', 'Sleep Initiation and Maintenance Disorders-experienced-Neoplasms', 'Diabetes Mellitus-correlate-Hypotension', 'Calcinosis-detected-Aortic Valve Stenosis', 'Pain, Postoperative-thought-Prostatitis', 'Peripheral Vascular Diseases-reveal-Death', 'Aneurysm-reveal-Death', 'Hypertension-result-Ventricular Remodeling', 'Aneurysm-relate-Renal Insufficiency, Chronic', 'Movement Disorders-associated-Gait Disorders, Neurologic', 'Gait Disorders, Neurologic-associated-Movement Disorders', 'Drug-Related Side Effects and Adverse Reactions-include-Constipation', 'Drug-Related Side Effects and Adverse Reactions-include-Diarrhea', 'Hypotension-suffer-Heart Failure', 'Hypotension-lead-Heart Failure', 'Heart Failure-referred-Heart Failure, Diastolic', 'Hypotension-result-Hypertension', 'Necrosis-characterized-Retinal Degeneration', 'Ocular Hypertension-consider-Unconsciousness', 'Obesity-provide-Death', 'Obesity-increased-Death', 'Death-increased-Obesity', 'Hyperglycemia-associated-Intracranial Hemorrhages', 'Intracranial Hemorrhages-associated-Hyperglycemia', 'Dementia-participate-Death', 'Osteoporotic Fractures-increase-Hip Fractures', 'Fatigue-improve-Brain Injuries, Traumatic', 'Fatigue-improve-Parkinson Disease', 'Brain Injuries, Traumatic-improve-Parkinson Disease', 'Sleepiness-improve-Parkinson Disease', 'Parkinson Disease-improve-Fatigue Syndrome, Chronic', 'Carcinoma, Hepatocellular-made-Neoplasms', 'Growth Disorders-reflect-Genetic Diseases, Inborn', 'Abnormalities, Drug-Induced-reflect-Genetic Diseases, Inborn', 'Bone Marrow Failure Disorders-reflect-Genetic Diseases, Inborn', 'Neoplasms-reflect-Genetic Diseases, Inborn', 'Epilepsy-appear-Seizures', 'Lymphoma, T-Cell, Cutaneous-considered-Skin Diseases', 'Spinal Cord Injuries-include-Muscular Atrophy', 'Prostatitis-cause-Urinary Bladder Neck Obstruction', 'Colonic Neoplasms-expressed-Neoplasms', 'Syncope-diagnosed-Sick Sinus Syndrome', 'Leukoencephalopathies-associated-Parkinson Disease, Secondary', 'Parkinson Disease, Secondary-associated-Leukoencephalopathies', 'Kidney Diseases-imply-Ischemia', 'Heart Failure-occur-Renal Artery Obstruction', 'Atherosclerosis-cause-Kidney Diseases', 'Atherosclerosis-cause-Hypertension', 'Kidney Diseases-cause-Hypertension', 'Kidney Diseases-cause-Atherosclerosis', 'Skin Diseases-inhibit-Drug-Related Side Effects and Adverse Reactions', 'Muscle Weakness-support-Neuromuscular Diseases', 'Blindness-considered-Vision Disorders', 'Neurodegenerative Diseases-lead-Multiple Sclerosis', 'Neurodegenerative Diseases-lead-Stroke', 'Neurodegenerative Diseases-lead-Inflammation', 'Central Nervous System Diseases-become-Infections', 'Central Nervous System Diseases-become-Inflammation', 'Multiple Sclerosis-lead-Inflammation', 'Stroke-lead-Inflammation', 'Inflammation-lead-Nerve Degeneration', 'Stroke-related-Rheumatic Heart Disease', 'Stroke-related-Infections', 'Heredodegenerative Disorders, Nervous System-lack-Dementia', 'Stroke-bring-Communicable Diseases', 'Plaque, Atherosclerotic-established-Stroke', 'Plaque, Atherosclerotic-established-Peripheral Nervous System Diseases', 'Plaque, Atherosclerotic-present-Cerebral Infarction', 'Cerebral Infarction-present-Carotid Artery Diseases', 'Stomach Neoplasms-caused-Cerebrovascular Disorders', 'Aphasia-caused-Cerebrovascular Disorders', 'Diabetes Mellitus-create-Arterio-Arterial Fistula', 'Atherosclerosis-create-Arterio-Arterial Fistula', 'Hernia-include-Pulmonary Disease, Chronic Obstructive', 'Hernia-incorporate-Pulmonary Disease, Chronic Obstructive', 'Hernia-include-Hypertension', 'Hernia-incorporate-Hypertension', 'Hernia-include-Aortic Aneurysm', 'Hernia-incorporate-Aortic Aneurysm', 'Hernia-include-Diabetes Mellitus', 'Hernia-incorporate-Diabetes Mellitus', 'Carcinoma, Squamous Cell-account-Lung Neoplasms', 'Colorectal Neoplasms-hospitalized-Hemorrhage', 'Stroke-compare-Nervous System Diseases', 'Motor Neuron Disease-include-Neurodegenerative Diseases', 'Rupture-include-Iris Diseases', 'Alzheimer Disease-include-Parkinsonian Disorders', 'Parkinsonian Disorders-include-Chronic Disease', 'Parkinsonian Disorders-include-Aneurysm', 'Parkinsonian Disorders-include-Arthralgia', 'Aneurysm-include-Chronic Disease', 'Hypertension-include-Pulmonary Disease, Chronic Obstructive', 'Hypertension-include-Arrhythmias, Cardiac', 'Neoplasms-implicated-Parkinson Disease, Secondary', 'Neoplasms-implicated-Alzheimer Disease', 'Neoplasms-implicated-Liver Cirrhosis', 'Neoplasms-implicated-Cataract', 'Alzheimer Disease-culminate-Death', 'Glucose Metabolism Disorders-noted-Dementia', 'Weight Gain-noted-Dementia', 'Fractures, Bone-include-Obesity', 'Peripheral Arterial Disease-associated-Stroke', 'Stroke-associated-Peripheral Arterial Disease', 'Achlorhydria-associated-Malabsorption Syndromes', 'Malabsorption Syndromes-associated-Achlorhydria', 'Leukemia, Myeloid-demonstrate-Leukemia, Myeloid, Acute', 'Leukemia, Myeloid-demonstrate-Myelodysplastic Syndromes', 'Hypothalamic Neoplasms-associated-Atherosclerosis', 'Atherosclerosis-associated-Hypothalamic Neoplasms', 'Diabetes Mellitus-suffer-Heart Diseases', 'Diabetes Mellitus-suffer-Stroke', 'Heart Diseases-suffer-Hypertension', 'Stroke-suffer-Hypertension', 'Parkinson Disease-related-Neurodegenerative Diseases', 'Parkinson Disease-interact-Neurodegenerative Diseases', 'Mitochondrial Diseases-remain-Parkinson Disease', 'Venous Thrombosis-treated-Death', 'Venous Thrombosis-attributed-Death', 'Pulmonary Embolism-attributed-Death', 'Cartilage Diseases-lead-Arthritis', 'Infections-reflect-Hepatitis C', 'Chronic Pain-shown-Obesity', 'Heart Failure-decline-Death', 'Prostatic Neoplasms-treated-Hypogonadism', 'Infections-characterized-Neoplasms', 'Inflammation-characterized-Neoplasms', 'Neoplasms-treated-Hypogonadism', 'Inflammatory Bowel Diseases-identify-Colitis, Ulcerative', 'Colitis, Ulcerative-distinguish-Hemorrhage', 'Colorectal Neoplasms-undergo-Colitis, Ulcerative', 'Death-destined-Dementia', 'Chronic Disease-apply-Dementia', 'Death-occur-Severe Acute Respiratory Syndrome', 'Acute Kidney Injury-observed-Diabetes Mellitus', 'Diabetes Mellitus-elevate-Acute Kidney Injury', 'Renal Insufficiency-promote-Cardiovascular Diseases', 'Death-involve-Heart Failure', 'Sclerosis-associated-Aneurysm', 'Aneurysm-associated-Sclerosis', 'Diabetes Mellitus-compared-Coronary Artery Disease', 'Fibrosis-affect-Carcinogenesis', 'Pain-reveal-Seizures', 'Hypothermia-under-recognised-Stroke', 'Hypothermia-under-recognised-Craniocerebral Trauma', 'Hypothermia-under-recognised-Multiple Sclerosis', 'Restless Legs Syndrome-disturb-Leg Injuries', 'Leg Injuries-associated-Disorders of Excessive Somnolence', 'Disorders of Excessive Somnolence-associated-Leg Injuries', 'Drug-Related Side Effects and Adverse Reactions-documented-Bone Marrow Diseases', 'Eunuchism-result-Endocrine System Diseases', 'Hypothyroidism-operated-Tongue Neoplasms', 'Hypothyroidism-develop-Sepsis', 'Tongue Neoplasms-develop-Sepsis', 'Hypothyroidism-pertain-Arthralgia', 'Obesity-pertain-Arthralgia', 'Hypoxia-contribute-Renal Insufficiency, Chronic', 'Osteoarthritis-associated-Foot Ulcer', 'Foot Ulcer-associated-Osteoarthritis', 'Communicable Diseases-predict-Cardiovascular Diseases', 'Bradycardia-predict-Cardiovascular Diseases', 'Renal Insufficiency, Chronic-reduce-Kidney Failure, Chronic', 'Mitochondrial Diseases-explain-Diabetes Mellitus', 'Urinary Incontinence-report-Obesity', 'Werner Syndrome-represent-Aging, Premature', 'Werner Syndrome-represent-Growth Disorders', 'Parkinson Disease-involved-Neurodegenerative Diseases', 'Genetic Diseases, Inborn-play-Neoplasms', 'Critical Illness-remain-Dementia', 'Vertigo-occur-Hypertension', 'Emphysema-involve-Inflammation', 'Pulmonary Disease, Chronic Obstructive-involve-Inflammation', 'Parkinson Disease-administered-Death', 'Death-occur-Parkinson Disease', 'Movement Disorders-administered-Death', 'Hepatitis E-cause-Chemical and Drug Induced Liver Injury', 'End Stage Liver Disease-tested-Hepatitis E', 'Chemical and Drug Induced Liver Injury-cause-End Stage Liver Disease', 'Hepatitis E-increase-End Stage Liver Disease', 'Hepatitis E-result-Liver Failure', 'Hepatitis E-considered-Liver Diseases', 'Obesity-recommended-Weight Loss', 'Muscular Diseases-include-Weight Loss', 'Adenomatous Polyposis Coli-characterized-Colonic Polyps', 'Fistula-use-Pain', 'Fistula-use-Hemorrhage', 'Fistula-use-Contusions', 'Fistula-use-Edema', 'Metabolic Syndrome-identify-Obesity', 'Infections-develop-Bacteriuria', 'Death-discussed-Brain Diseases', 'Brain Diseases-treat-Cardiovascular Diseases', 'Memory Disorders-shown-Alzheimer Disease', 'Arthritis, Rheumatoid-accompanied-Inflammation', 'Arthritis, Rheumatoid-lead-Intracranial Arterial Diseases', 'Dyspnea-noted-Chest Pain', 'Autonomic Dysreflexia-removed-Nociceptive Pain', 'Spinal Cord Injuries-removed-Nociceptive Pain', 'Quadriplegia-admitted-Chest Pain', 'Embolism-show-Thrombosis', 'Infections-show-Muscular Disorders, Atrophic', 'Infections-show-Gastritis', 'Infections-identify-Death', 'Kidney Diseases-relate-Heart Failure', 'Fractures, Bone-computed-Death', 'Carotid Artery Diseases-provoke-Cerebral Infarction', 'Fallopian Tube Diseases-protect-Cardiovascular Diseases', 'Fallopian Tube Diseases-protect-Neoplasms', 'Hip Fractures-underline-Osteoporosis', 'Cholera-proceed-Malabsorption Syndromes', 'Anemia, Megaloblastic-associated-Fallopian Tube Diseases', 'Fallopian Tube Diseases-associated-Anemia, Megaloblastic', 'Hip Fractures-associated-Fragile X Syndrome', 'Fragile X Syndrome-associated-Hip Fractures', 'Heart Diseases-exhibit-Atrioventricular Block', 'Hypertension-help-Diabetes Mellitus', 'Hypertension-help-Kidney Diseases', 'Hypertension-predict-Cardiovascular Diseases', 'Venous Thrombosis-receive-Venous Thromboembolism', 'Osteoporosis-fall-Parkinson Disease', 'Nervous System Diseases-associated-Inflammation', 'Inflammation-associated-Nervous System Diseases', 'Nervous System Diseases-driven-Infections', 'Nerve Degeneration-driven-Infections', 'Inflammation-driven-Infections', 'Mitochondrial Diseases-affect-Colonic Neoplasms', 'Alzheimer Disease-raise-Dementia', 'Chronic Disease-address-Hip Fractures', 'Genetic Diseases, Inborn-lead-Nerve Degeneration', 'Genetic Diseases, Inborn-focus-Huntington Disease', 'Nerve Degeneration-focus-Huntington Disease', 'Dementia-see-Chronic Disease', 'Asthma-report-Arthritis', 'Atherosclerosis-shift-Constriction, Pathologic', 'Atherosclerosis-shift-Inflammation', 'Atherosclerosis-shift-Thrombosis', 'Epilepsy, Temporal Lobe-contribute-Seizures', 'Death-seem-Obesity', 'Atherosclerosis-manifest-Inflammation', 'Epilepsy, Temporal Lobe-relate-Learning Disabilities', 'Restless Legs Syndrome-associated-Uremia', 'Uremia-associated-Restless Legs Syndrome', 'Sleep Wake Disorders-represent-Sleep Initiation and Maintenance Disorders', 'Sleep Apnea Syndromes-represent-Sleep Initiation and Maintenance Disorders', 'Sleep Wake Disorders-increase-Death', 'Hemolytic-Uremic Syndrome-suggested-Sleep Wake Disorders', 'Restless Legs Syndrome-represent-Sleep Initiation and Maintenance Disorders', 'Werner Syndrome-suggest-Inflammation', 'Neuralgia-continue-Exanthema', 'Alzheimer Disease-involved-Atrophy', 'Alzheimer Disease-involved-Cerebral Infarction', 'Glycogen Storage Disease Type II-include-Retinal Diseases', 'Atrophy-involved-Dementia, Vascular', 'Cerebral Infarction-related-Dementia, Vascular', 'Cerebral Infarction-involved-Dementia, Vascular', 'Low Back Pain-radiate-Neck Pain', 'Low Back Pain-associated-Neck Pain', 'Neck Pain-associated-Low Back Pain', 'Hypogonadism-affect-Death', 'Kidney Diseases-reflect-Fibrosis', 'Renal Insufficiency-associated-Renal Artery Obstruction', 'Renal Artery Obstruction-associated-Renal Insufficiency', 'Kidney Failure, Chronic-associated-Renal Artery Obstruction', 'Renal Artery Obstruction-associated-Kidney Failure, Chronic', 'Lymphoma-give-Airway Obstruction', 'Airway Obstruction-included-Lymphoma', 'Airway Obstruction-need-Lymphoma', 'Lymphoma-included-Lacrimal Duct Obstruction', 'Lymphoma-need-Lacrimal Duct Obstruction', 'Malformations of Cortical Development-render-Alzheimer Disease', 'Malformations of Cortical Development-render-Dementia', 'Neurodegenerative Diseases-associated-Tooth Injuries', 'Tooth Injuries-associated-Neurodegenerative Diseases', 'Myasthenia Gravis-associated-Thymoma', 'Thymoma-associated-Myasthenia Gravis', 'Myasthenia Gravis-become-Muscular Disorders, Atrophic', 'Thymoma-become-Muscular Disorders, Atrophic', 'Acute Kidney Injury-occur-Critical Illness', 'Fractures, Bone-increased-Renal Insufficiency, Chronic', 'Infections-protect-Pneumonia', 'Osteoporosis-affect-Renal Insufficiency, Chronic', 'Osteoporosis-affect-Kidney Failure, Chronic', 'Chronic Kidney Disease-Mineral and Bone Disorder-diagnose-Kidney Diseases', 'Fractures, Bone-predict-Kidney Diseases', 'Leukoencephalopathies-accelerate-Headache', 'Leukoencephalopathies-accelerate-Hypotension', 'Hypertension-observed-Dementia, Vascular', 'Hypertension-observed-Alzheimer Disease', 'Hypotension-related-Dementia', 'Atrial Fibrillation-prove-Stroke', 'Scoliosis-treat-Spinal Diseases', 'Giant Cell Arteritis-suspect-Fibromyalgia', 'Systemic Vasculitis-suspect-Fibromyalgia', 'Hypothalamic Neoplasms-associated-Dementia', 'Dementia-associated-Hypothalamic Neoplasms', 'Ischemia-studied-Coronary Artery Disease', 'Aging, Premature-present-Autoimmune Diseases', 'Autoimmune Diseases-reported-Aging, Premature', 'Aging, Premature-reported-Autoimmune Diseases', 'Autoimmune Diseases-lead-Aging, Premature', 'Hypertrophy, Left Ventricular-related-Hypertension', 'Multiple Organ Failure-adapted-Chronic Disease', 'Diabetes Mellitus-suffer-Dementia', 'Multiple Organ Failure-adapted-Neoplasms', 'Epilepsy-apply-Seizures', 'Hyperparathyroidism, Secondary-lead-Chronic Kidney Disease-Mineral and Bone Disorder', 'Chronic Kidney Disease-Mineral and Bone Disorder-exacerbate-Hyperparathyroidism', 'Heart Failure, Diastolic-surroun-Heart Failure, Systolic', 'Neoplasms-reduce-Inflammation', 'Sleep Wake Disorders-elicited-Parkinson Disease', 'Heart Failure, Diastolic-arise-Diabetes Mellitus', 'Heart Failure, Diastolic-include-Diabetes Mellitus', 'Heart Failure, Diastolic-arise-Hypertension', 'Heart Failure, Diastolic-include-Hypertension', 'Heart Failure, Diastolic-arise-Ischemia', 'Heart Failure, Diastolic-include-Ischemia', 'Heart Failure, Diastolic-attributed-Hypertrophy', 'Heart Failure, Diastolic-attributed-Fibrosis', 'Neoplasms-identified-Leukemia, Myeloid, Acute', 'Kidney Tubular Necrosis, Acute-occur-Ischemia', 'Kidney Tubular Necrosis, Acute-involve-Wounds and Injuries', 'Kidney Tubular Necrosis, Acute-include-Wounds and Injuries', 'Kidney Tubular Necrosis, Acute-include-Hypoxia', 'Kidney Tubular Necrosis, Acute-involve-Adenocarcinoma', 'Kidney Tubular Necrosis, Acute-include-Adenocarcinoma', 'Vasculitis-cause-Acute Kidney Injury', 'Acute Kidney Injury-include-Shock', 'Acute Kidney Injury-manage-Shock', 'Acute Kidney Injury-include-Respiratory Insufficiency', 'Acute Kidney Injury-manage-Respiratory Insufficiency', 'Acute Kidney Injury-include-Pulmonary Edema', 'Acute Kidney Injury-manage-Pulmonary Edema', 'Acute Kidney Injury-include-Acidosis', 'Acute Kidney Injury-manage-Acidosis', 'Acute Kidney Injury-manage-Sepsis', 'Blood Platelet Disorders-associated-Gastrointestinal Hemorrhage', 'Gastrointestinal Hemorrhage-associated-Blood Platelet Disorders', 'Carotid Artery Diseases-reported-Neoplasms', 'Neoplasms-prescribed-Pain', 'Neoplasm Metastasis-prescribed-Pain', 'Headache-seen-Muscle Weakness', 'Ankle Fractures-decrease-Fractures, Bone', 'Xeroderma Pigmentosum-discuss-Death', 'Headache Disorders, Secondary-exacerbated-Endocrine System Diseases', 'Headache Disorders, Secondary-exacerbated-Pain', 'Diabetes Mellitus-treat-Mesenteric Vascular Occlusion', 'Diabetes Mellitus-treat-Nervous System Diseases', 'Diabetes Mellitus-treat-Infections', 'Calcinosis-encroach-Fibrosis', 'Calcinosis-result-HIV Infections', 'Calcinosis-result-Chronic Disease', 'Calcinosis-result-Metabolic Diseases', 'Ovarian Neoplasms-describe-Hypotension', 'Diabetes Mellitus-increase-Nocturia', 'Hypertension-increase-Nocturia', 'Drug Hypersensitivity-increase-Nocturia', 'Delirium-diagnosed-Neoplasms', 'Peptic Ulcer-accounted-Gastrointestinal Hemorrhage', 'Gastritis-accounted-Gastrointestinal Hemorrhage', 'Esophageal Neoplasms-accounted-Gastrointestinal Hemorrhage', 'Neoplasm Invasiveness-seen-Carcinoma, Ductal', 'Dementia-fit-Alzheimer Disease', 'Neoplasms-managed-Breast Neoplasms', 'Coronary Artery Disease-accelerate-Cardiovascular Abnormalities', 'Coronary Artery Disease-associated-Hereditary Angioedema Type III', 'Hereditary Angioedema Type III-associated-Coronary Artery Disease', 'Alzheimer Disease-exacerbate-Neurodegenerative Diseases', 'Osteoporosis-accelerate-Cardiovascular Abnormalities', 'Osteoporosis-associated-Hereditary Angioedema Type III', 'Hereditary Angioedema Type III-associated-Osteoporosis', 'Cardiovascular Abnormalities-associated-Hereditary Angioedema Type III', 'Hereditary Angioedema Type III-associated-Cardiovascular Abnormalities', 'Ovarian Diseases-protect-Coronary Artery Disease', 'Ovarian Diseases-protect-Osteoporosis', 'Mucocutaneous Lymph Node Syndrome-result-Angina Pectoris', 'Death-examine-Colorectal Neoplasms', 'Hypertrophy-represent-Neurotoxicity Syndromes', 'Hypertrophy-represent-Dementia', 'Cardiac Output, Low-model-Neoplasms', 'Colitis, Ulcerative-predispose-Colorectal Neoplasms', 'Colitis, Ulcerative-associated-Neoplasms', 'Neoplasms-associated-Colitis, Ulcerative', 'Inflammation-predispose-Colorectal Neoplasms', 'Alzheimer Disease-summarized-Plaque, Amyloid', 'Prostatic Hyperplasia-differentiate-Prostatic Neoplasms', 'Intervertebral Disc Degeneration-seek-Back Pain', 'Hypertension-recognize-Sensation Disorders', 'Diabetes Mellitus-recognize-Sensation Disorders', 'Cardiovascular Diseases-recognize-Sensation Disorders', 'Infections-need-Obesity', 'Delirium-precipitate-Pain', 'Diabetes Mellitus-followed-Cataract', 'Death-increased-Pneumonia', 'Death-increased-Pneumococcal Infections', 'Aneurysm-seen-Atherosclerosis', 'Atherosclerosis-seen-Giant Cell Arteritis', 'Inflammatory Bowel Diseases-diagnose-Diverticulum', 'Lung Diseases-occur-Neoplasms', 'Cardiovascular Diseases-range-Metabolic Syndrome', 'Nephritis, Interstitial-accompanied-Hypoxia', 'Pain-reduce-Drug Eruptions', 'Pain-prevent-Neuralgia', 'Drug Eruptions-prevent-Neuralgia', 'Paralysis-represent-Dysphonia', 'Dysphonia-objectify-Paralysis', 'Cardiac Output, Low-fall-Multiple Sclerosis', 'Breast Neoplasms-fall-Cardiac Output, Low', 'Osteoporosis-fall-Multiple Sclerosis', 'Inflammation-triggered-Brain Injuries, Traumatic', 'Hypertension-investigate-Stroke', 'Hypertension-investigate-Myocardial Infarction', 'Osteomalacia-induce-Osteoporosis', 'Osteomalacia-caused-Fluorosis, Dental', 'Immunologic Deficiency Syndromes-caused-Fluorosis, Dental', 'Osteoporosis-induce-Bone Diseases', 'Glaucoma-contribute-Vision Disorders', 'Osteoporosis-caused-Fluorosis, Dental', 'Bone Diseases-caused-Fluorosis, Dental', 'Musculoskeletal Diseases-caused-Fluorosis, Dental', 'Glaucoma-suffer-Vision Disorders', 'Vision Disorders-suffer-Hematologic Diseases', 'Glaucoma-suffer-Hematologic Diseases', 'Heart Failure, Diastolic-related-Hypotension', 'Hypertrophy-appear-Obesity', 'Heart Failure, Diastolic-appear-Obesity', 'Obesity-appear-Hypotension', 'Asthenia-associated-Neoplasms', 'Neoplasms-associated-Asthenia', 'Heart Failure-rank-Chronic Disease', 'Dysphonia-suppress-Spasm', 'Pain-occur-Dementia', 'Dementia-contribute-Pain', 'Renal Insufficiency-associated-Restless Legs Syndrome', 'Restless Legs Syndrome-associated-Renal Insufficiency', 'Carcinogenesis-develop-Neoplasms', 'Nervous System Diseases-associated-Restless Legs Syndrome', 'Restless Legs Syndrome-associated-Nervous System Diseases', 'Carcinogenesis-destined-Neoplasms', 'Tremor-associated-Restless Legs Syndrome', 'Restless Legs Syndrome-associated-Tremor', 'Spinocerebellar Degenerations-associated-Restless Legs Syndrome', 'Restless Legs Syndrome-associated-Spinocerebellar Degenerations', 'Pain-discussed-Neuralgia', 'Pain-discussed-Fibromyalgia', 'Pain-discussed-Toothache', 'Pain-discussed-Burning Mouth Syndrome', 'Prostatic Neoplasms-underlie-Neoplasms', 'Thrombophilia-increase-Cardiovascular Diseases', 'Chronic Disease-report-Obesity', 'Cardiomyopathies-include-Memory Disorders', 'Atrophy-include-Cardiomyopathies', 'Erectile Dysfunction-present-Prostatic Hyperplasia', 'Prostatic Hyperplasia-result-Erectile Dysfunction', 'Communicable Diseases-distinguish-Infections', 'Conjunctival Diseases-observed-Neoplasms', 'Atrial Fibrillation-occur-Tachycardia', 'Tachycardia, Paroxysmal-indicated-Atrial Fibrillation', 'Hypertension-influenced-Inflammation', 'Kidney Failure, Chronic-develop-Hypertrophy, Left Ventricular', 'Kidney Failure, Chronic-develop-Coronary Artery Disease', 'Kidney Failure, Chronic-develop-Stroke', 'Kidney Failure, Chronic-develop-Aneurysm', 'Arterial Occlusive Diseases-represent-Atherosclerosis', 'Plaque, Atherosclerotic-represent-Atherosclerosis', 'Diabetes Mellitus-suggest-Alzheimer Disease', 'Hyperglycemia-involved-Alzheimer Disease', 'Diabetic Angiopathies-involved-Alzheimer Disease', 'Diabetes Mellitus-involved-Neoplasms', 'Hyperglycemia-cause-Carcinogenesis', 'Basal Ganglia Diseases-observed-Leukoencephalopathies', 'Diabetes Mellitus-include-Hearing Loss', 'Retinal Vein Occlusion-observed-Thrombosis', 'Retinal Vein Occlusion-compare-Atherosclerosis', 'Multiple Chronic Conditions-reflect-Retinal Vein Occlusion', 'Calcinosis-compare-Myocardial Infarction', 'Calcinosis-compare-Angina, Stable', 'Calcinosis-detected-Angina, Stable', 'Myocardial Infarction-compare-Angina, Stable', 'Colorectal Neoplasms-associated-Carcinoma', 'Carcinoma-associated-Colorectal Neoplasms', 'Inflammation-associated-Gallstones', 'Gallstones-associated-Inflammation', 'Cystic Fibrosis-remain-Lung Diseases', 'Drug Hypersensitivity Syndrome-associated-Death', 'Death-associated-Drug Hypersensitivity Syndrome', 'Vision Disorders-based-Blindness', 'Blindness-launch-Cataract', 'Hypoxia-rest-Hypercapnia', 'Hemophilia A-involve-Hemorrhage', 'Mitochondrial Diseases-documented-Alzheimer Disease', 'Mitochondrial Diseases-documented-Huntington Disease', 'Mitochondrial Diseases-documented-Amyotrophic Lateral Sclerosis', 'Constipation-define-Short Bowel Syndrome', 'Infections-result-Pneumonia', 'Heart Failure-distinguish-Chest Pain', 'Heart Failure-distinguish-Syncope', 'Airway Obstruction-related-Cardiomyopathy, Hypertrophic', 'Werner Syndrome-analyzed-Diabetes Mellitus', 'Werner Syndrome-analyzed-Neoplasms', 'Hyperhomocysteinemia-incriminated-Plaque, Atherosclerotic', 'Arthritis, Rheumatoid-evaluate-Venous Thrombosis', 'Hyperhomocysteinemia-found-Arthritis, Rheumatoid', 'Heart Diseases-improve-Stroke', 'Stroke-alter-Alzheimer Disease', 'Cerebral Infarction-develop-Dementia', 'Alzheimer Disease-increased-Hypertension', 'Alzheimer Disease-increased-Atherosclerosis', 'Alzheimer Disease-increased-Atrial Fibrillation', 'Bradycardia-affect-Arrhythmias, Cardiac', 'Ventricular Fibrillation-affect-Arrhythmias, Cardiac', 'Hemorrhage-induced-Fractures, Bone', 'Hemorrhage-induced-Wounds and Injuries', 'Myocardial Infarction-determined-Metabolic Syndrome', 'Diabetes Mellitus-characterized-Obesity, Abdominal', 'Death-observed-Hearing Disorders', 'Drug-Related Side Effects and Adverse Reactions-uncover-Death', 'Fatigue-perceive-Sleepiness', 'Fatigue-perceive-Mental Fatigue', 'Fatigue-include-Pain', 'Retinal Diseases-evaluated-Macular Degeneration', 'Retinal Diseases-evaluated-Diabetes Mellitus', 'Death-explain-Kidney Failure, Chronic', 'Metabolic Diseases-characterized-Fractures, Bone', 'Cardiovascular Diseases-increase-Arrhythmias, Cardiac', 'Coronary Artery Disease-contribute-Arrhythmias, Cardiac', 'Fibrosis-develop-Heart Diseases', 'Fibrosis-develop-Tachycardia, Ventricular', 'Cardiovascular Abnormalities-underlie-Heart Failure', 'Fibrosis-develop-Ventricular Fibrillation', 'Cardiovascular Abnormalities-underlie-Cardiomyopathy, Hypertrophic', 'Cardiovascular Abnormalities-underlie-Myocardial Infarction', 'Cardiovascular Abnormalities-caused-Death', 'Cardiovascular Abnormalities-caused-Tachycardia, Ventricular', 'Cardiovascular Abnormalities-underlie-Tachycardia, Ventricular', 'Cardiovascular Abnormalities-underlie-Ventricular Fibrillation', 'Hyperthyroidism-tend-Weight Loss', 'Hyperthyroidism-tend-Arrhythmias, Cardiac', 'Heart Failure-caused-Death', 'Heart Failure-caused-Tachycardia, Ventricular', 'Death, Sudden, Cardiac-caused-Tachycardia, Ventricular', 'Death, Sudden, Cardiac-caused-Ventricular Fibrillation', 'Cardiomyopathy, Hypertrophic-caused-Death', 'Cardiomyopathy, Hypertrophic-caused-Tachycardia, Ventricular', 'Myocardial Infarction-caused-Death', 'Death-predominate-Respiratory Tract Diseases', 'Myocardial Infarction-caused-Tachycardia, Ventricular', 'Death-caused-Tachycardia, Ventricular', 'Intellectual Disability-thrive-Contracture', 'Death-caused-Ventricular Fibrillation', 'Intellectual Disability-thrive-Kyphosis', 'Cataract-thrive-Contracture', 'Cataract-thrive-Kyphosis', 'Contracture-thrive-Kyphosis', 'Death-predominate-Neurodegenerative Diseases', 'Osteochondritis-caused-Wounds and Injuries', 'Hematoma, Subdural, Chronic-known-Intracranial Hemorrhages', 'Hematoma, Subdural, Chronic-appear-Wounds and Injuries', 'Tremor-considered-Neurodegenerative Diseases', 'Intracranial Hemorrhages-appear-Wounds and Injuries', 'Neurologic Manifestations-considered-Neurodegenerative Diseases', 'Neurologic Manifestations-follow-Headache', 'Hematoma, Subdural, Chronic-account-Neurodegenerative Diseases', 'Skin Abnormalities-seen-Progeria', 'Muscular Dystrophies-exhibit-Alzheimer Disease', 'Heart Failure-belong-Pneumococcal Infections', 'Pain-suggest-Appendicitis', 'Constipation-suggest-Short Bowel Syndrome', 'Short Bowel Syndrome-suggest-Appendicitis', 'Nervous System Diseases-include-Leukomalacia, Periventricular', 'Nervous System Diseases-include-Hypoxia-Ischemia, Brain', 'Nervous System Diseases-include-Costello Syndrome', 'Nervous System Diseases-include-Classical Lissencephalies and Subcortical Band Heterotopias', 'Nervous System Diseases-include-Cerebral Palsy', 'Lymphoproliferative Disorders-arise-Infections', 'Acromegaly-characterized-Fractures, Bone', 'Acromegaly-characterized-Hypogonadism', 'Dysgeusia-do-Fibrosis', 'Pain-consider-Sleep Deprivation', 'Vision Disorders-defined-Death', 'Burkitt Lymphoma-include-Lymphoma', 'Diabetes Mellitus-used-Stroke', 'Diabetes Mellitus-incorporate-Stroke', 'Cardiovascular Diseases-used-Stroke', 'Cardiovascular Diseases-incorporate-Stroke', 'Atrial Fibrillation-used-Stroke', 'Atrial Fibrillation-incorporate-Stroke', 'Vision Disorders-evaluated-Optic Nerve Diseases', 'Vision Disorders-evaluated-Diabetes Mellitus', 'Respiratory Syncytial Virus Infections-underlie-Pulmonary Disease, Chronic Obstructive', 'Hypertension-assessed-Diabetes Mellitus', 'Hypertension-calculated-Cardiovascular Diseases', 'Hypertension-assessed-Hypercholesterolemia', 'Stomach Neoplasms-produce-Stomach Diseases', 'Diabetes Mellitus-investigated-Hypertension', 'Diabetes Mellitus-investigated-Coronary Artery Disease', 'Diabetes Mellitus-investigated-Stroke', 'Diabetes Mellitus-double-Coronary Artery Disease', 'Diabetes Mellitus-double-Stroke', 'Jaw, Edentulous-factored-Tooth Loss', 'Jaw, Edentulous-prevent-Tooth Loss', 'Atrophy-related-Dementia', 'Adrenal Insufficiency-result-Hypothalamic Diseases', 'Adrenal Insufficiency-result-Hypophysitis', 'Adrenal Insufficiency-react-Hypothalamic Neoplasms', 'Neoplasms-involve-Pain', 'Neoplasms-experience-Pain', 'Cardiomyopathy, Hypertrophic-associated-Heart Diseases', 'Heart Diseases-associated-Cardiomyopathy, Hypertrophic', 'Anemia-associated-Hypertrophy, Left Ventricular', 'Hypertrophy, Left Ventricular-associated-Anemia', 'Inflammation-associated-Hypertrophy, Left Ventricular', 'Hypertrophy, Left Ventricular-associated-Inflammation', 'Diabetes Mellitus-increase-Ischemia', 'Hypertension-increase-Ischemia', 'Hypercholesterolemia-increase-Ischemia', 'Seizures-decrease-Chronic Disease', 'Amyloidosis-result-Memory Disorders', 'Death-predicted-Weight Loss', 'Death-predicted-Anemia', 'Death-predicted-Renal Insufficiency', 'Alzheimer Disease-administer-Dementia', 'Death-increase-Psychoses, Substance-Induced', 'Airway Obstruction-result-Hypocalcemia', 'Parkinson Disease, Secondary-characterized-Alzheimer Disease', 'Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis-associated-Death', 'Death-associated-Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis', 'Tachycardia-induced-Atrial Fibrillation', 'Cardiovascular Diseases-increased-Atrial Fibrillation', 'Death-increased-Hypertension', 'Death-increased-Atrial Fibrillation', 'Atrial Fibrillation-increase-Ventricular Dysfunction, Left', 'Obesity, Abdominal-develop-Hypertension', 'Inflammation-develop-Hypertension', 'Pulmonary Disease, Chronic Obstructive-associate-Respiratory Tract Infections', 'Respiratory Tract Infections-associate-Pulmonary Disease, Chronic Obstructive', 'Stroke-associate-Respiratory Tract Infections', 'Respiratory Tract Infections-associate-Stroke', 'Protein S Deficiency-underlie-Spherocytosis, Hereditary', 'Ovarian Diseases-assess-Infertility, Female', 'Seizures-present-Stroke', 'Encephalitis-characterized-Seizures', 'Encephalitis-characterized-Memory Disorders', 'Limbic Encephalitis-associated-Neoplasms', 'Neoplasms-associated-Limbic Encephalitis', 'Encephalitis-associated-Seizures', 'Seizures-associated-Encephalitis', 'Encephalitis-associated-Fever', 'Fever-associated-Encephalitis', 'Encephalitis-accompany-Fever', 'Encephalitis-associated-Nervous System Diseases', 'Nervous System Diseases-associated-Encephalitis', 'Encephalitis-accompany-Nervous System Diseases', 'Seizures-accompany-Fever', 'Seizures-accompany-Nervous System Diseases', 'Pneumonia-lead-Cough', 'Pneumonia-lead-Dyspnea', 'Infections-lead-Cough', 'Infections-lead-Dyspnea', 'Critical Illness-pose-Acute Kidney Injury', 'Cold Injury-account-Death', 'Kidney Failure, Chronic-develop-Hyperphosphatemia', 'Kidney Failure, Chronic-develop-Tetany', 'Headache Disorders, Secondary-cautioned-Breast Neoplasms', 'Alzheimer Disease-subdivided-Dementia', 'Confusion-used-Delirium', 'Confusion-diagnosis-Delirium', 'Dementia-used-Memory Disorders', 'Jaw, Edentulous-associated-Obesity', 'Obesity-associated-Jaw, Edentulous', 'Colonic Neoplasms-relieve-Constipation', 'Colorectal Neoplasms-represent-Neoplasms', 'Death-evaluate-Pneumonia', 'Xerostomia-caused-Chronic Disease', 'Xerostomia-lead-Dental Caries', 'Xerostomia-lead-Infections', "Xerostomia-caused-Sjogren's Syndrome", 'Kidney Failure, Chronic-assess-Myocardial Infarction', 'Acute Kidney Injury-cause-Renal Insufficiency, Chronic', 'Cardiac Output, Low-defined-Hip Fractures', 'Cardiac Output, Low-claim-Hip Fractures', 'Cardiac Output, Low-claim-Fractures, Bone', 'Ischemia-combined-Necrosis', 'Hypertension-weakened-Death', 'Mitochondrial Diseases-occur-Alzheimer Disease', 'Earache-alleviated-Pain', 'Drug-Related Side Effects and Adverse Reactions-include-Bone Marrow Diseases', 'Death-quantified-Alzheimer Disease', 'Obesity-grow-Cardiovascular Diseases', 'Infections-decreased-Esophageal Neoplasms', 'Mucositis-occur-Gastroesophageal Reflux', 'Carcinoma, Hepatocellular-occur-Hepatitis C', 'Carcinoma, Hepatocellular-accelerate-Hepatitis, Viral, Human', 'Carcinoma, Hepatocellular-accelerate-Fibrosis', 'Neoplasms-influence-Metabolic Side Effects of Drugs and Substances', 'Neoplasms-diminish-Drug-Related Side Effects and Adverse Reactions', 'Carcinoma, Squamous Cell-seem-Melanoma', 'Werner Syndrome-show-Hypertension', 'Werner Syndrome-show-Drug Hypersensitivity', 'Hypopituitarism-remain-Pituitary Diseases', 'Muscular Diseases-present-Muscle Weakness', 'Muscular Diseases-present-Contracture', 'Muscular Diseases-present-Reflex, Abnormal', 'Atrial Fibrillation-perpetuate-Ventricular Fibrillation', 'Gallstones-expected-Obesity', 'Gallbladder Diseases-inhibit-Gallstones', 'Cholelithiasis-associated-Cholangiocarcinoma', 'Cholangiocarcinoma-associated-Cholelithiasis', 'Hypertension-found-Metabolic Syndrome', 'Obesity-predict-Renal Insufficiency, Chronic', 'Brain Injuries, Traumatic-measured-Coma', 'Fractures, Compression-describe-Bone Marrow Failure Disorders', 'Fractures, Bone-describe-Bone Marrow Failure Disorders', 'Aortic Aneurysm, Thoracic-carry-Death', 'Rupture-carry-Death', 'Necrosis-reflect-Chemical and Drug Induced Liver Injury', 'Necrosis-transform-Chemical and Drug Induced Liver Injury', 'Albuminuria-extend-Death', 'Respiratory Tract Diseases-develop-Immunologic Deficiency Syndromes', 'Proteinuria-reduce-Cardiovascular Diseases', 'Respiratory Tract Diseases-develop-Meningitis, Bacterial', 'Proteinuria-reduce-Death', 'Proteinuria-reduce-Renal Insufficiency, Chronic', 'Immunologic Deficiency Syndromes-develop-Meningitis, Bacterial', 'Death-associated-Diarrhea', 'Diarrhea-associated-Death', 'Infections-involve-Cystic Fibrosis', 'Infections-treat-Cystic Fibrosis', 'Cerebrovascular Disorders-include-Inflammation', 'Inflammatory Bowel Diseases-include-Inflammation', 'Infarction-diagnosed-Hemorrhage', 'Infarction-diagnosed-Subarachnoid Hemorrhage', 'Ischemia-diagnosed-Hemorrhage', 'Ischemia-diagnosed-Subarachnoid Hemorrhage', 'Parkinson Disease, Secondary-use-Death', 'Alzheimer Disease-expressed-Dementia', 'Chronic Disease-associated-Heart Diseases', 'Heart Diseases-associated-Chronic Disease', 'Sepsis-increase-Multiple Organ Failure', 'Muscle Hypertonia-include-Fecal Incontinence', 'Stroke-decreased-Hypertension', 'Infections-develop-Ossification, Heterotopic', 'Renal Insufficiency-cause-Rickets, Hypophosphatemic', 'Renal Insufficiency-accompanied-Hyperplasia', 'Renal Insufficiency-accompanied-Hyperparathyroidism', 'Renal Insufficiency-accompanied-Chronic Kidney Disease-Mineral and Bone Disorder', 'Hyperphosphatemia-accompanied-Hyperplasia', 'Hyperphosphatemia-accompanied-Hyperparathyroidism', 'Hyperphosphatemia-accompanied-Chronic Kidney Disease-Mineral and Bone Disorder', 'Neoplasms-begin-Tertiary Lymphoid Structures', 'Bronchitis-associated-Pulmonary Disease, Chronic Obstructive', 'Pulmonary Disease, Chronic Obstructive-associated-Bronchitis', 'Pulmonary Disease, Chronic Obstructive-related-Death', 'Pulmonary Disease, Chronic Obstructive-underreported-Death', 'Pulmonary Disease, Chronic Obstructive-mentioned-Death', 'Fractures, Bone-defined-Spinal Cord Injuries', 'Spinal Cord Injuries-compare-Death', 'Death-related-Osteoporosis', 'Infarction-associated-Cerebral Infarction', 'Cerebral Infarction-associated-Infarction', 'Hemorrhage-associated-Cerebral Hemorrhage', 'Cerebral Hemorrhage-associated-Hemorrhage', 'Stroke-analyzed-Death', 'Hypothyroidism-underlie-Thyroid Diseases', 'Renal Insufficiency, Chronic-comprise-Kidney Diseases', 'Renal Insufficiency, Chronic-predict-Kidney Diseases', 'Renal Insufficiency, Chronic-comprise-Diabetes Mellitus', 'Kidney Diseases-comprise-Diabetes Mellitus', 'Renal Insufficiency, Chronic-defined-Renal Insufficiency', 'Chronic Disease-prevail-Diabetic Nephropathies', 'Chronic Disease-prevail-Hypertension', 'Diabetic Nephropathies-prevail-Aneurysm', 'Aneurysm-prevail-Hypertension', 'Aneuploidy-lead-Neoplasms', 'Death-remain-Atrial Fibrillation', 'Coronary Artery Disease-relieve-Angina Pectoris', 'Hypertension-study-Stroke', 'Stroke-study-Dementia', 'Hip Fractures-multiplied-Fractures, Bone', 'Aneurysm-play-Alzheimer Disease', 'Atrophy-map-Alzheimer Disease', 'Aneurysm-warrant-Alzheimer Disease', 'Alzheimer Disease-lead-Atrophy', 'Fractures, Bone-show-Fatigue', 'Cerebrovascular Disorders-confirmed-Death', 'Weight Gain-promote-Obesity', 'Cataract-prevent-Accidental Injuries', 'Vision Disorders-associated-Accidental Injuries', 'Accidental Injuries-associated-Vision Disorders', 'Parkinson Disease-help-Neurodegenerative Diseases', 'Osteoarthritis-leave-Fatigue', 'Soft Tissue Infections-involve-Infections', 'Obesity, Abdominal-increase-Chronic Disease', 'Obesity, Abdominal-increase-Neoplasms', 'Spondylitis-considered-Back Pain', 'Spondylitis-considered-Tuberculosis', 'Lewy Body Disease-include-Neurodegenerative Diseases', 'Kidney Diseases-growing-Diabetes Mellitus', 'Hypertension-use-Proteinuria', 'Diabetes Mellitus-use-Proteinuria', 'Neurologic Manifestations-implicated-Chronic Kidney Disease-Mineral and Bone Disorder', 'Atrial Fibrillation-prevent-Venous Thrombosis', 'Atrial Fibrillation-prevent-Pulmonary Embolism', 'Cerebral Infarction-prevent-Venous Thrombosis', 'Cerebral Infarction-prevent-Pulmonary Embolism', 'Erectile Dysfunction-accompany-Diabetes Mellitus', 'Syncope-contribute-Erectile Dysfunction', 'Cardiovascular Diseases-underlie-Erectile Dysfunction', 'Diabetes Mellitus-reveal-Death', 'Headache Disorders, Secondary-treat-Obesity', 'Headache Disorders, Secondary-treat-Diabetes Mellitus', 'Headache Disorders, Secondary-treat-Hypertension', 'Heart Failure, Diastolic-presumed-Hypotension', 'Motion Sickness-reduced-Hypotension', 'Heart Failure, Diastolic-account-Heart Failure', 'Heart Failure, Diastolic-account-Atrial Fibrillation', 'Death-excluded-Dementia', 'Dementia-excluded-Death', 'Dementia-explain-Weight Loss', 'Dementia-explain-Death', 'Ovarian Neoplasms-compare-Drug-Related Side Effects and Adverse Reactions', 'Hypertension-predict-Retinal Diseases', 'Retinal Diseases-suspected-Mastocytosis, Systemic', 'Diabetes Mellitus-predict-Retinal Diseases', 'Atrophy-investigate-Dementia', 'Death-under-utilized-Pulmonary Disease, Chronic Obstructive', 'Death-under-utilized-Cardiovascular Diseases', 'Acquired Immunodeficiency Syndrome-receive-Neoplasms', 'Acute Kidney Injury-associated-Asymptomatic Infections', 'Asymptomatic Infections-associated-Acute Kidney Injury', 'Neoplasms-exhibit-Lymphoma, Non-Hodgkin', 'Lymphoma, Non-Hodgkin-misdiagnosed-Glioblastoma', 'Neoplasms-tend-Lymphoma, Non-Hodgkin', 'Lymphoma, Non-Hodgkin-tend-Neoplasms', 'Neoplasms-composed-Necrosis', 'Neoplasms-distinguished-Hemangioendothelioma', 'Neoplasms-distinguished-Hemangiosarcoma', 'Status Epilepticus-show-Critical Illness', 'Inflammation-increase-Pancreatic Neoplasms', 'Adenocarcinoma-prevent-Neoplasm Metastasis', 'Neoplasms-prevent-Neoplasm Metastasis', 'Drug-Related Side Effects and Adverse Reactions-seen-Neutropenia', 'Drug-Related Side Effects and Adverse Reactions-seen-Diarrhea', 'Drug-Related Side Effects and Adverse Reactions-seen-Neurotoxicity Syndromes', 'Drug-Related Side Effects and Adverse Reactions-seen-Fatigue', 'Drug-Related Side Effects and Adverse Reactions-seen-Nausea', 'Aphasia, Conduction-characterized-Memory Disorders', 'Neoplasms-characterised-Death', 'Brain Diseases-affect-HIV Infections', 'Weight Loss-experience-Diabetes Mellitus', 'Weight Loss-experience-Sleep Wake Disorders', 'Weight Loss-experience-Hypertension', 'Weight Loss-experience-Osteoarthritis', 'Tuberculosis, Pulmonary-present-Tuberculosis', 'Tuberculosis, Pulmonary-characterised-Death', 'Alzheimer Disease-classified-Neurodegenerative Diseases', 'Heart Failure-increasing-Myocardial Infarction', 'Parkinson Disease, Secondary-reveal-Astrocytoma', 'Ulcer-exist-Pain', 'Pain Insensitivity, Congenital-evaluate-Pain', 'Hypertension-treated-Peripheral Arterial Disease', 'Diabetes Mellitus-treated-Peripheral Arterial Disease', 'Intermittent Claudication-improve-Hypercholesterolemia', 'Dyslipidemias-treated-Peripheral Arterial Disease', 'Intermittent Claudication-manifest-Pain', 'Hypothyroidism-treated-Peripheral Arterial Disease', 'Intermittent Claudication-manifest-Ulcer', 'Intermittent Claudication-manifest-Infections', 'Intermittent Claudication-manifest-Gangrene', 'Intermittent Claudication-manifest-Impotence, Vasculogenic', 'Ischemia-threatening-Pain', 'Ischemia-manifest-Pain', 'Ischemia-threatening-Ulcer', 'Ischemia-manifest-Ulcer', 'Infections-threatening-Ischemia', 'Gangrene-threatening-Ischemia', 'Ischemia-manifest-Impotence, Vasculogenic', 'Xerostomia-cause-Pain', 'Hemorrhagic Disorders-found-Cerebral Small Vessel Diseases', 'Muscular Dystrophy, Duchenne-improve-Osteoporosis', 'Infections-decline-Neoplasms', 'Parkinson Disease-experience-Seizures', 'Infections-acquire-Diabetes Mellitus', 'Infections-acquire-Heart Diseases', 'Pulmonary Disease, Chronic Obstructive-obtained-Heart Failure', 'Heart Failure-overlook-Pulmonary Disease, Chronic Obstructive', 'Pulmonary Disease, Chronic Obstructive-present-Dyspnea', 'Myocardial Infarction-present-Cardiomyopathy, Dilated', 'Epileptic Syndromes-determined-Epilepsies, Partial', 'Seizures-determined-Epilepsies, Partial', 'Seizures-increase-Stroke', 'Death-experience-Seizures', 'Epilepsy-predominate-Seizures', 'Polymyositis-diagnosed-Arteritis', 'Headache-diagnosed-Arteritis', 'Atrial Fibrillation-experience-Heart Failure', 'Delirium-overlooked-Dementia', 'Dwarfism, Pituitary-influence-Atherosclerosis', 'Infarction, Middle Cerebral Artery-reduce-Brain Edema', 'Inflammation-increase-Necrosis', 'Dehydration-induced-Cardiovascular Diseases', 'Dehydration-induced-Heart Arrest', 'Dehydration-induced-Stroke', 'Osteoporosis-involved-Wounds and Injuries', 'Gastritis-expressed-Anemia, Megaloblastic', 'Gastritis-triggered-Wounds and Injuries', 'Autoimmune Diseases-triggered-Wounds and Injuries', 'Polyendocrinopathies, Autoimmune-triggered-Wounds and Injuries', 'Gastritis-characterised-Achlorhydria', 'Hemoglobinopathies-develop-Hypertension, Pulmonary', 'Hypertension, Pulmonary-lead-Heart Failure', 'Hypertension, Pulmonary-lead-Death', 'Inflammation-considered-Neoplasms', 'Inflammation-considered-Diabetes Mellitus, Type 2', 'Inflammation-considered-Cardiovascular Diseases', 'Inflammation-considered-Neurodegenerative Diseases', 'Prostatic Neoplasms-carry-Neoplasms', 'Kidney Diseases-linked-Genetic Diseases, Inborn', 'Neoplasms-linked-Genetic Diseases, Inborn', 'Death-prevent-Infarction', 'Cerebral Amyloid Angiopathy-detected-Alzheimer Disease', 'Diabetes Mellitus-progress-Kidney Diseases', 'Cerebral Hemorrhage-seen-Alzheimer Disease', 'Cerebral Hemorrhage-found-Cerebral Amyloid Angiopathy', 'Alzheimer Disease-found-Cerebral Amyloid Angiopathy', 'Cerebral Amyloid Angiopathy-show-Dementia', 'Cerebral Amyloid Angiopathy-confirm-Alzheimer Disease', 'Cerebral Amyloid Angiopathy-seen-Hypertension', 'Dementia-confirm-Alzheimer Disease', 'Alzheimer Disease-seen-Hypertension', 'Cardiac Output, Low-present-Pulmonary Disease, Chronic Obstructive', 'Cardiac Output, Low-present-Coronary Artery Disease', 'Lymphoma-comprise-Mastocytosis, Systemic', 'Nerve Degeneration-raise-HIV Infections', 'Nerve Degeneration-raise-Neurodegenerative Diseases', 'Nervous System Diseases-associated-Immunologic Deficiency Syndromes', 'Immunologic Deficiency Syndromes-associated-Nervous System Diseases', "Lupus Erythematosus, Systemic-observed-Sjogren's Syndrome", 'Lymphoproliferative Disorders-occur-Immunologic Deficiency Syndromes', 'Thyroid Diseases-occur-Hypothyroidism', 'Hyperthyroidism-linked-Death', 'Polyuria-found-Diabetes Insipidus, Nephrogenic', 'Fibrosis-acquire-Infections', 'Fibrosis-occur-Infections', 'Renal Insufficiency, Chronic-reflect-Kidney Diseases', 'Fibrosis-become-Hepatitis C', 'Hepatitis C-derived-Infections', 'Fibrosis-derived-Infections', 'Carcinoma, Hepatocellular-derived-Infections', 'Rheumatic Diseases-characterized-Keratoconjunctivitis Sicca', 'Rheumatic Diseases-characterized-Xerostomia', "Dry Eye Syndromes-involve-Sjogren's Syndrome", 'Osteoarthritis-combine-Pelvic Neoplasms', 'Eccrine Porocarcinoma-resemble-Skin Neoplasms', 'Eccrine Porocarcinoma-show-Carcinoma', 'Eccrine Porocarcinoma-overlooked-Carcinoma, Squamous Cell', 'Eccrine Porocarcinoma-misinterprete-Carcinoma, Squamous Cell', 'Eccrine Porocarcinoma-overlooked-Skin Neoplasms', 'Eccrine Porocarcinoma-misinterprete-Skin Neoplasms', 'Heart Septal Defects, Atrial-appear-Hypertension, Pulmonary', 'Heart Septal Defects, Atrial-appear-Ventricular Dysfunction, Right', 'Sunburn-result-Skin Neoplasms', 'Sunburn-include-Carcinoma, Basal Cell', 'Sunburn-include-Carcinoma, Squamous Cell', 'Sunburn-result-Melanoma', 'Migraine Disorders-presented-Headache', 'Glucose Metabolism Disorders-increase-Diabetes Mellitus', 'Ankle Injuries-associated-Gait Disorders, Neurologic', 'Gait Disorders, Neurologic-associated-Ankle Injuries', 'Drug-Related Side Effects and Adverse Reactions-occur-Death', 'Low Back Pain-emulate-Radiculopathy', 'Pain-emulate-Radiculopathy', 'Abdominal Pain-emulate-Radiculopathy', 'Muscle Weakness-include-Radiculopathy', 'Muscle Weakness-include-Spinal Cord Diseases', 'HIV Infections-link-Immunologic Deficiency Syndromes', 'Prostatic Neoplasms-confirmed-Neoplasms', 'Cardiovascular Diseases-Establish-Alzheimer Disease', 'Polycystic Ovary Syndrome-contribute-Metabolic Syndrome', 'Metabolic Syndrome-carry-Cardiovascular Diseases', 'Diabetes Mellitus-carry-Cardiovascular Diseases', 'Hypertension-carry-Cardiovascular Diseases', 'Diabetic Nephropathies-present-Gangrene', 'Kidney Failure, Chronic-leading-Obesity', 'Ulcer-progress-Abscess', 'Hypotension, Orthostatic-result-Syncope, Vasovagal', 'Torsades de Pointes-lead-Syncope', 'Torsades de Pointes-lead-Ventricular Fibrillation', 'Torsades de Pointes-lead-Death, Sudden', 'Arrhythmias, Cardiac-lead-Syncope', 'Arrhythmias, Cardiac-lead-Ventricular Fibrillation', 'Arrhythmias, Cardiac-lead-Death, Sudden', 'Myalgia-present-Heart Failure', 'Myalgia-present-Myocarditis', 'Parkinsonian Disorders-found-Parkinson Disease', 'Myalgia-devastate-Cardiomyopathies', 'Parkinsonian Disorders-found-Alzheimer Disease', 'Heart Failure-devastate-Myocarditis', 'Heart Failure-devastate-Cardiomyopathies', 'Stroke-assess-Cardiomyopathies', 'Stroke-assess-Renal Insufficiency', 'Chronic Disease-seem-Pain', 'Hypertrophy-develop-Hyperpigmentation', 'Hemangioma-established-Neoplasms', 'Spinal Cord Injuries-screened-Cardiovascular Diseases', 'Hypotension, Orthostatic-result-Syncope', 'Breast Neoplasms-decrease-Fractures, Bone', 'Fatigue-associated-Adrenal Insufficiency', 'Adrenal Insufficiency-associated-Fatigue', 'Erectile Dysfunction-reduce-Cardiovascular Diseases', 'Retinal Arterial Macroaneurysm-associated-Retinal Vein Occlusion', 'Retinal Vein Occlusion-associated-Retinal Arterial Macroaneurysm', 'Aortic Valve Stenosis-include-Heart Valve Diseases', 'Aortic Valve Insufficiency-include-Heart Valve Diseases', 'Mitral Valve Insufficiency-include-Heart Valve Diseases', 'Tricuspid Valve Insufficiency-include-Heart Valve Diseases', 'Heart Diseases-result-Heart Rupture', 'Wounds and Injuries-prepared-Heart Rupture', 'Wounds and Injuries-associated-Heart Rupture', 'Heart Rupture-associated-Wounds and Injuries', 'Alzheimer Disease-considered-Memory Disorders', 'Pulmonary Disease, Chronic Obstructive-associated-Deglutition Disorders', 'Deglutition Disorders-associated-Pulmonary Disease, Chronic Obstructive', 'Pain-associated-Deglutition Disorders', 'Deglutition Disorders-associated-Pain', 'Death-represent-Wounds and Injuries', 'Hernia, Ventral-repair-Death', 'Epilepsy-enhance-Hyperhomocysteinemia', 'Hyperhomocysteinemia-related-Central Nervous System Diseases', 'Hyperhomocysteinemia-linked-Dementia', 'Hyperhomocysteinemia-reduce-Nervous System Diseases', 'Dementia-reduce-Nervous System Diseases', 'Parkinsonian Disorders-seen-Movement Disorders', 'Hyperhomocysteinemia-contribute-Neurodegenerative Diseases', 'Weight Loss-evolve-Musculoskeletal Diseases', 'Hip Fractures-treated-Osteoporosis', 'Vasculitis-emerge-Fever', 'Granulomatous Disease, Chronic-emerge-Fever', 'Gastritis, Atrophic-seem-Osteoporosis', 'Anemia-implicated-Osteoporosis', 'Infections-implicated-Osteoporosis', 'Thrombocytopenia-develop-Nephritis', 'Thrombocytopenia-develop-Deafness', 'Hearing Loss, Central-lead-Renal Insufficiency', 'Cataract-lead-Renal Insufficiency', 'Nephritis-lead-Renal Insufficiency', 'Kidney Diseases-cause-Deafness', 'Kidney Diseases-result-Thrombocytopenia', 'Kidney Diseases-cause-Nephritis', 'Cataract-cause-Deafness', 'Cataract-result-Thrombocytopenia', 'Cataract-cause-Nephritis', 'Deafness-result-Thrombocytopenia', 'Thrombocytopenia-produce-Nephritis', 'Wounds and Injuries-promote-Cutaneous Fistula', 'Wounds and Injuries-produce-Pigmentation Disorders', 'Cutaneous Fistula-produce-Pigmentation Disorders', 'Fragile X Syndrome-cause-Intellectual Disability', 'Shock, Cardiogenic-influence-Death', 'Fractures, Bone-observed-Epilepsy', 'Fractures, Bone-accelerate-Osteoporosis', 'Epilepsy-accelerate-Osteoporosis', 'Melanoma-originate-Neoplasms', 'Neoplasms-concern-Obesity', 'Carcinogenesis-caused-Neoplasms', 'Obesity-reversed-Diabetes Mellitus', 'Obesity-reversed-Hypertension', 'Oligospermia-decrease-Hyperammonemia', 'Osteoarthritis-highlight-Rheumatic Diseases', 'Aneuploidy-predispose-Alzheimer Disease', 'Reperfusion Injury-lead-Myocardial Infarction', 'Reperfusion Injury-lead-Arrhythmias, Cardiac', 'Reperfusion Injury-lead-Neurologic Manifestations', 'Respiratory Tract Diseases-associated-Arbovirus Infections', 'Arbovirus Infections-associated-Respiratory Tract Diseases', 'Atherosclerosis-concur-Thyroid Diseases', 'Cardiovascular Diseases-concur-Thyroid Diseases', 'Death-concur-Thyroid Diseases', 'Cardiovascular Diseases-prevent-Alzheimer Disease', 'Neoplasms-prevent-Alzheimer Disease', 'Erectile Dysfunction-characterized-Diabetes Mellitus', 'Erectile Dysfunction-characterized-Heart Diseases', 'Erectile Dysfunction-characterized-Hypertension', 'Erectile Dysfunction-share-Cardiovascular Diseases', 'Wounds and Injuries-cause-Death', 'Neoplasms-treated-Death', 'Death-focused-Respiratory Tract Infections', 'Heart Failure-manifested-Delirium', 'Cardiovascular Abnormalities-occur-Heart Failure', 'Neutropenia-experience-Infections', 'Optic Neuropathy, Ischemic-associated-Erectile Dysfunction', 'Erectile Dysfunction-associated-Optic Neuropathy, Ischemic', 'Diabetes Mellitus-reflect-Erectile Dysfunction', 'Diabetes Mellitus-reflect-Mastocytosis, Systemic', 'Hypertension-reflect-Erectile Dysfunction', 'Hypertension-reflect-Mastocytosis, Systemic', 'Hypogonadism-reflect-Erectile Dysfunction', 'Hypogonadism-reflect-Mastocytosis, Systemic', 'Hypercholesterolemia-reflect-Erectile Dysfunction', 'Hypercholesterolemia-reflect-Mastocytosis, Systemic', 'Erectile Dysfunction-reflect-Mastocytosis, Systemic', 'Cardiovascular Diseases-diagnosed-Metabolic Syndrome', 'Sleep Initiation and Maintenance Disorders-result-Sleep Wake Disorders', 'Dementia-confused-Alzheimer Disease', 'Dementia-represent-Neurodegenerative Diseases', 'Pulmonary Disease, Chronic Obstructive-increase-Sleep Initiation and Maintenance Disorders', 'Diabetes Mellitus-increase-Sleep Initiation and Maintenance Disorders', 'Dementia-increase-Sleep Initiation and Maintenance Disorders', 'Chronic Pain-increase-Sleep Initiation and Maintenance Disorders', 'Neoplasms-increase-Sleep Initiation and Maintenance Disorders', 'Sleep Apnea, Obstructive-result-Death', 'Sleep Wake Disorders-ascribed-Sleepiness', 'Sleep Wake Disorders-ascribed-Fatigue', 'Sleep Wake Disorders-ascribed-Nocturia', 'Sleep Wake Disorders-range-Sleep Initiation and Maintenance Disorders', 'Sleep Wake Disorders-result-Delirium', 'Disorders of Excessive Somnolence-result-Delirium', 'Disorders of Excessive Somnolence-result-Psychomotor Disorders', 'Hypertriglyceridemia-caused-Hyperlipoproteinemia Type I', 'Death-identified-Heart Failure', 'Death-identified-Pulmonary Disease, Chronic Obstructive', 'Death-identified-Renal Insufficiency', 'Heart Failure-considered-Atrial Fibrillation', 'Heart Failure-include-Thromboembolism', 'Heart Failure-underlie-Thromboembolism', 'Atrial Fibrillation-include-Thromboembolism', 'Atrial Fibrillation-underlie-Thromboembolism', 'Alzheimer Disease-presented-Hepatolenticular Degeneration', 'Cerebrovascular Disorders-underlie-Atherosclerosis', 'Cerebrovascular Disorders-underlie-Diabetes Mellitus', 'Cerebrovascular Disorders-underlie-Arthritis', 'Psychomotor Disorders-observed-Alzheimer Disease', 'Death-increase-Pulmonary Disease, Chronic Obstructive', 'Fecal Incontinence-increase-Infections', 'Constipation-affect-Parkinson Disease', 'Constipation-affect-Arthritis, Rheumatoid', 'Vision Disorders-diminish-Glaucoma', 'Memory Disorders-occur-Brain Injuries', 'Hypertension-remain-Diabetes Mellitus', 'Cerebrovascular Disorders-remain-Diabetes Mellitus', 'Pulmonary Disease, Chronic Obstructive-remain-Diabetes Mellitus', 'Neoplasms-remain-Diabetes Mellitus', 'Osteoarthritis-remain-Diabetes Mellitus', 'Constipation-considered-Gastroesophageal Reflux', 'Esophageal Neoplasms-include-Gastroesophageal Reflux', 'Cardiovascular Diseases-hasten-Hypertension', 'Osteoporosis-cause-Osteomalacia', 'Osteoporosis-cause-Myalgia', 'Osteoporosis-cause-Chronic Pain', 'Communicable Diseases-cause-Osteomalacia', 'Communicable Diseases-misdiagnosed-Myalgia', 'Muscle Weakness-treated-Fractures, Bone', 'Communicable Diseases-misdiagnosed-Chronic Pain', 'Osteomalacia-increase-Fractures, Bone', 'Osteomalacia-cause-Myalgia', 'Osteomalacia-cause-Chronic Pain', 'Myalgia-misdiagnosed-Chronic Pain', 'Choroiditis-lead-Vision Disorders', 'Urinary Incontinence-associate-Death', 'Death-associate-Urinary Incontinence', 'Colorectal Neoplasms-restricted-Short Bowel Syndrome', 'Colorectal Neoplasms-restricted-Neoplasm Metastasis', 'Facial Pain-used-Pain', 'Facial Pain-test-Pain', 'Dyskeratosis Congenita-overlap-Anemia, Aplastic', 'Drug Hypersensitivity-include-Neurologic Manifestations', 'Drug Hypersensitivity-precipitated-Neurologic Manifestations', 'Deglutition Disorders-result-Neoplasms', 'Deglutition Disorders-develop-Neoplasms', 'Deglutition Disorders-result-Fistula', 'Deglutition Disorders-complicated-Fistula', 'Dental Caries-associated-Death', 'Death-associated-Dental Caries', 'Dental Caries-associated-Pneumonia', 'Pneumonia-associated-Dental Caries', 'Neoplasms-complicated-Fistula', 'Fistula-occur-Neoplasms', 'Aortic Aneurysm-result-Deglutition Disorders', 'Hypercholesterolemia-associated-Chronic Disease', 'Chronic Disease-associated-Hypercholesterolemia', 'Neurodegenerative Diseases-lead-Memory Disorders', 'Pain-seen-Acute Pain', 'Sleep Wake Disorders-pre-date-Seizures', 'Sleep Wake Disorders-occur-Epilepsy', 'Dementia-diagnosed-Stroke', 'Arthritis, Rheumatoid-cause-Joint Diseases', 'Mastocytosis, Systemic-cause-Joint Diseases', 'Diverticulitis-include-Abdominal Pain', 'Neoplasms-occur-Seminoma', 'Syncope-reported-Hypotension, Orthostatic', 'Bone Neoplasms-underlie-Osteoporosis', 'Chest Pain-detect-Neoplasms', 'Anemia-worsen-Headache Disorders, Secondary', 'Respiratory Insufficiency-result-Respiratory Tract Infections', 'Leukemia, B-Cell-recovered-Adenocarcinoma', 'Death-increase-Vascular Calcification', 'Vascular Calcification-observed-Death', 'Primary Ovarian Insufficiency-result-Infertility, Female', 'Death-underlie-Pulmonary Disease, Chronic Obstructive', 'Heart Failure-experience-Dyspnea', 'Acute Disease-excluded-Heart Failure', 'Dyspnea-help-Heart Failure', 'Chronic Disease-excluded-Heart Failure', 'Dyspnea-excluded-Heart Failure', 'Diabetes Mellitus-contribute-Cerebral Infarction', 'Hypertrophy-account-Eosinophilia', 'Fibrosis-suppress-Tachycardia', 'Inflammation-reduce-Erythema', 'Edema-reduce-Erythema', 'Carcinogenesis-block-Neoplasms', 'Lung Neoplasms-consider-Death', 'Kidney Calculi-screened-Renal Insufficiency', 'Kidney Calculi-screened-Peptic Ulcer', 'Infections-increasing-HIV Infections', 'Alzheimer Disease-demonstrate-Plaque, Amyloid', 'Weight Loss-fall-Cardiac Output, Low', 'Tremor-suggest-Parkinson Disease', 'Aneurysm-followed-Death', 'Aortic Aneurysm-followed-Death', 'Respiratory System Abnormalities-denoted-Death', 'Death-denoted-Cardiovascular Diseases', 'Periodontitis-contribute-Respiratory Tract Infections', 'Periodontal Diseases-contribute-Respiratory Tract Infections', 'Thrombosis-caused-Aneurysm', 'Hypotension, Orthostatic-reported-Urinary Incontinence', 'Hypotension, Orthostatic-reported-Sexual Dysfunction, Physiological', 'Hypotension, Orthostatic-reported-Erectile Dysfunction', 'Sick Sinus Syndrome-cause-Bradycardia', 'Hypothyroidism-treated-Growth Disorders', 'Hypothyroidism-prevent-Growth Disorders', 'Neurodegenerative Diseases-related-Heredodegenerative Disorders, Nervous System', 'Neurodegenerative Diseases-related-Dementia', 'Dementia, Vascular-relate-Microvascular Angina', 'Dementia, Vascular-relate-Diabetes Mellitus', 'Microvascular Angina-resemble-Diabetes Mellitus', 'Neutropenia-associated-Hepatitis B, Chronic', 'Hepatitis B, Chronic-associated-Neutropenia', 'Neutropenia-associated-Arbovirus Infections', 'Arbovirus Infections-associated-Neutropenia', 'Lung Neoplasms-identified-Neoplasms', 'Ankle Fractures-associated-Osteoporosis', 'Osteoporosis-associated-Ankle Fractures', 'Hip Fractures-result-Fractures, Bone', 'Ankle Fractures-manage-Fractures, Bone', 'Osteoporosis-considered-Sarcopenia', 'Osteoporosis-give-Fractures, Bone', 'Vision, Low-occur-Vision Disorders', 'Fractures, Bone-considered-Sarcopenia', 'Renal Insufficiency, Chronic-suffer-Hyperglycemia', 'Renal Insufficiency, Chronic-suffer-Cardiovascular Diseases', 'Renal Insufficiency, Chronic-suffer-Inflammation', 'Death-use-Stroke', 'Death-modeling-Stroke', 'Death-modeling-Atrial Fibrillation', 'Stroke-modeling-Atrial Fibrillation', 'Inflammation-influence-Alzheimer Disease', 'Nocturia-affect-Death', 'Nocturia-fall-Polyuria', 'Polyuria-contribute-Nocturia', 'Urinary Bladder, Overactive-used-Nocturia', 'End Stage Liver Disease-become-Death', 'End Stage Liver Disease-need-Chemical and Drug Induced Liver Injury', 'Death-need-Chemical and Drug Induced Liver Injury', 'End Stage Liver Disease-result-Death', 'Dementia-include-Fecal Incontinence', 'Colonic Neoplasms-present-Cystic Fibrosis', 'Colitis-cause-Death', 'Dysentery-reduce-Death', 'Irritable Bowel Syndrome-considered-Abdominal Pain', 'Irritable Bowel Syndrome-considered-Diarrhea', 'Irritable Bowel Syndrome-considered-Constipation', 'Kidney Failure, Chronic-compared-Neoplasms', 'Respiratory Tract Infections-follow-Neoplasms', 'Respiratory Tract Infections-follow-Menstruation Disturbances', 'Respiratory Tract Diseases-follow-Neoplasms', 'Mitochondrial Diseases-represent-Diabetes Mellitus', 'Respiratory Tract Diseases-follow-Menstruation Disturbances', 'Communicable Diseases-follow-Neoplasms', 'Communicable Diseases-follow-Menstruation Disturbances', 'Brain Diseases-underlie-Cerebrovascular Disorders', 'Brain Diseases-underlie-Neurodegenerative Diseases', 'Diabetes Mellitus-treated-Patellar Dislocation', 'Diabetes Mellitus-sustain-Patellar Dislocation', 'Diabetes Mellitus-treated-Fractures, Bone', 'Fractures, Bone-occur-Knee Injuries', 'Diabetes Mellitus-demonstrate-Hypotension', 'Diabetes Mellitus-produced-Hypertension', 'Hypotension-produced-Hypertension', 'Hypotension-related-Diabetes Mellitus', 'Hypotension-related-Hypertension', 'Constipation-associated-Abdominal Pain', 'Abdominal Pain-associated-Constipation', 'Pneumonia-compare-Bacterial Infections', 'Pneumonia-increased-Infections', 'Bacterial Infections-increased-Infections', 'Lung Diseases-affected-Pneumonia', 'Venous Thromboembolism-encompass-Venous Thrombosis', 'Venous Thromboembolism-encompass-Pulmonary Embolism', 'Venous Thromboembolism-encompass-Death', 'Sleep Initiation and Maintenance Disorders-consider-Sleep Wake Disorders', 'Diurnal Enuresis-consider-Sleep Wake Disorders', 'Necrosis-keep-Muscular Atrophy', 'Necrosis-keep-Muscular Dystrophy, Duchenne', 'Infections-lead-Stomach Diseases', 'Infections-lead-Stomach Neoplasms', 'Infections-obtain-Dyspnea', 'Infections-play-Alzheimer Disease', 'Immunologic Deficiency Syndromes-include-Fallopian Tube Diseases', 'Immunologic Deficiency Syndromes-include-Coronary Artery Disease', 'Immunologic Deficiency Syndromes-include-Stroke', 'Alzheimer Disease-include-Fibrosis', 'Hemolysis-represent-Hypertension, Pulmonary', 'Anemia, Sickle Cell-related-Hemolysis', 'Anemia, Sickle Cell-yield-Hemolysis', 'Anemia, Sickle Cell-yield-Hypertension, Pulmonary', 'Hypertension, Pulmonary-represent-Anemia, Sickle Cell', 'Death-compare-Intellectual Disability', 'Death-remain-Intellectual Disability', 'Mouth Diseases-examine-Dementia', 'Death-derived-Cerebral Infarction', 'Necrosis-observed-Gastrointestinal Stromal Tumors', 'Sleep Initiation and Maintenance Disorders-discuss-Erectile Dysfunction', 'Bone Neoplasms-include-Infections', 'Ventricular Dysfunction, Left-experience-Chronic Disease', 'Microvascular Angina-play-Cerebral Infarction', 'Infections-experience-Psychomotor Disorders', 'Sleep Wake Disorders-choose-Nocturia', 'Drug-Related Side Effects and Adverse Reactions-help-Breast Neoplasms', 'Death-prevent-Osteoporosis', 'Death-make-Osteoarthritis', 'Fractures, Bone-prevent-Osteoporosis', 'Fractures, Bone-make-Osteoarthritis', 'Osteoporosis-make-Osteoarthritis', 'Pain-decrease-Acute Pain', 'Diabetes Mellitus-implicated-Diabetic Angiopathies', 'Diabetes Mellitus-implicated-Neurodegenerative Diseases', 'Diabetes Mellitus-implicated-Neoplasms', 'Hemorrhage-seem-Ulcer', 'Infections-involved-Peptic Ulcer', 'Myopia-appear-Cataract', 'Drug-Related Side Effects and Adverse Reactions-include-Kidney Diseases', 'Drug-Related Side Effects and Adverse Reactions-include-Hematologic Diseases', 'Drug-Related Side Effects and Adverse Reactions-observed-Neurotoxicity Syndromes', 'Kidney Diseases-include-Hematologic Diseases', 'Kidney Diseases-observed-Neurotoxicity Syndromes', 'Hematologic Diseases-observed-Neurotoxicity Syndromes', 'Infections-caused-Pneumococcal Infections', 'Brain Injuries, Traumatic-detect-Intracranial Hemorrhages', 'Asthma-confirmed-Death', 'Vision Disorders-include-Chronic Disease', 'Vision Disorders-include-Fractures, Bone', 'Vision Disorders-include-Diabetes Mellitus', 'Vision Disorders-treat-Death', 'Vision Disorders-prevent-Death', 'Adrenal Insufficiency-appreciated-Dementia', 'Adrenal Insufficiency-result-Cerebral Arterial Diseases', 'Dementia-attributed-Cerebral Arterial Diseases', 'Dementia-result-Cerebral Arterial Diseases', 'Seizures-caused-Cerebrovascular Disorders', 'Seizures-caused-Craniocerebral Trauma', 'Seizures-caused-Neurodegenerative Diseases', 'Seizures-caused-Central Nervous System Neoplasms', 'Pulmonary Disease, Chronic Obstructive-associated-Colonic Neoplasms', 'Colonic Neoplasms-associated-Pulmonary Disease, Chronic Obstructive', 'Pulmonary Disease, Chronic Obstructive-associated-Urinary Bladder Neoplasms', 'Urinary Bladder Neoplasms-associated-Pulmonary Disease, Chronic Obstructive', 'Pulmonary Disease, Chronic Obstructive-undergo-Neoplasms', 'Psychoses, Substance-Induced-associated-Neurodegenerative Diseases', 'Neurodegenerative Diseases-associated-Psychoses, Substance-Induced', 'Parkinson Disease, Secondary-used-Parkinson Disease', 'Retinal Diseases-correlate-Abnormalities, Drug-Induced', 'Diabetes Mellitus-reported-Peripheral Nervous System Diseases', 'Upper Extremity Deformities, Congenital-associated-Neurologic Manifestations', 'Neurologic Manifestations-associated-Upper Extremity Deformities, Congenital', 'Cardiovascular Diseases-implicated-Hyperglycemia', 'Cardiovascular Diseases-caused-Hyperglycemia', 'Cardiovascular Diseases-implicated-Hyperlipidemias', 'Cardiovascular Diseases-caused-Hyperlipidemias', 'Cardiovascular Diseases-implicated-Hypertension', 'Cardiovascular Diseases-implicated-Vascular Calcification', 'Cardiovascular Diseases-implicated-Hyperphosphatemia', 'Cardiovascular Diseases-caused-Hyperphosphatemia', 'Pain-rate-Low Back Pain', 'Pain-rate-Neck Pain', 'Kidney Failure, Chronic-implicated-Hyperglycemia', 'Kidney Failure, Chronic-caused-Hyperglycemia', 'Kidney Failure, Chronic-implicated-Hyperlipidemias', 'Kidney Failure, Chronic-caused-Hyperlipidemias', 'Kidney Failure, Chronic-implicated-Hypertension', 'Kidney Failure, Chronic-implicated-Vascular Calcification', 'Kidney Failure, Chronic-implicated-Hyperphosphatemia', 'Kidney Failure, Chronic-caused-Hyperphosphatemia', 'Diabetes Mellitus-implicated-Hyperglycemia', 'Diabetes Mellitus-implicated-Hyperlipidemias', 'Diabetes Mellitus-caused-Hyperlipidemias', 'Diabetes Mellitus-implicated-Hypertension', 'Diabetes Mellitus-implicated-Vascular Calcification', 'Diabetes Mellitus-implicated-Hyperphosphatemia', 'Diabetes Mellitus-caused-Hyperphosphatemia', 'Hyperglycemia-caused-Vascular Calcification', 'Hyperlipidemias-caused-Vascular Calcification', 'Vascular Calcification-caused-Hyperphosphatemia', 'Osteoporotic Fractures-contribute-Death', 'Hematoma-remove-Hemorrhage', 'Cerebral Hemorrhage-affect-Hemorrhage', 'Cerebral Hemorrhage-counteract-Hematoma', 'Cerebral Hemorrhage-counteract-Death', 'Cerebral Hemorrhage-achieve-Hemorrhage', 'Stroke-achieve-Hemorrhage', 'Hemorrhage-reduce-Factor X Deficiency', 'Hemorrhage-reduce-Death', 'Factor X Deficiency-reduce-Hemorrhage', 'Hemorrhage-reduce-Thromboembolism', 'Heart Failure-costs-Heart Diseases', 'Hypotension-understand-Cardiovascular Diseases', 'Weight Loss-develop-Neoplasms', 'Necrolytic Migratory Erythema-develop-Neoplasms', 'Diarrhea-develop-Neoplasms', 'Neoplasms-expressed-Ischemia', 'Thyroid Diseases-associated-Alzheimer Disease', 'Alzheimer Disease-associated-Thyroid Diseases', 'Thyroid Diseases-result-Alzheimer Disease', 'Death-increase-Arthritis, Rheumatoid', 'Pain-undergo-Neoplasms', 'Mitochondrial Diseases-underlie-Alzheimer Disease', 'Vision Disorders-identify-Cardiovascular Diseases', 'Death-include-Peripheral Vascular Diseases', 'Death-include-Takotsubo Cardiomyopathy', 'Coronary Artery Disease-diagnosed-Ischemia', 'Hearing Loss, Sudden-exhibit-Hypertension', 'Hearing Loss, Sudden-exhibit-Diabetes Mellitus', 'Pain-establish-Fractures, Bone', 'Sleep Wake Disorders-cause-Sleepiness', 'Pain-manage-Fractures, Bone', 'Metabolic Syndrome-represented-Diabetes Mellitus, Type 2', 'Death-return-Wounds and Injuries', 'Fever-develop-Weight Loss', 'Tremor-associated-Primary Ovarian Insufficiency', 'Primary Ovarian Insufficiency-associated-Tremor', 'Ataxia-associated-Primary Ovarian Insufficiency', 'Primary Ovarian Insufficiency-associated-Ataxia', 'Hereditary Breast and Ovarian Cancer Syndrome-related-Obesity', 'Hereditary Breast and Ovarian Cancer Syndrome-predict-Death', 'Hereditary Breast and Ovarian Cancer Syndrome-predict-Diabetes Mellitus, Type 2', 'Parasitemia-associated-Malaria', 'Malaria-associated-Parasitemia', 'Thromboembolism-produce-Death', 'Thromboembolism-produce-Pulmonary Embolism', 'Peripheral Arterial Disease-emphasized-Diabetes Mellitus', 'Death-associated-Thromboembolism', 'Thromboembolism-associated-Death', 'Prostatic Hyperplasia-centered-Airway Obstruction', 'Prostatic Hyperplasia-centered-Prostatitis', 'Airway Obstruction-centered-Prostatitis', 'Prostatitis-involve-Prostatic Hyperplasia', 'Urinary Bladder Neck Obstruction-involve-Prostatic Hyperplasia', 'Neoplasm Metastasis-range-Breast Neoplasms', 'Neoplasms-range-Breast Neoplasms', 'Lupus Erythematosus, Systemic-become-Peripheral Vascular Diseases', 'Peripheral Vascular Diseases-defined-Gangrene', 'Peripheral Vascular Diseases-defined-Ischemia', 'Peripheral Vascular Diseases-defined-Ulcer', 'Dyslipidemias-affect-Peripheral Vascular Diseases', 'Ulcer-seen-Gangrene', 'Ulcer-seen-Constriction, Pathologic', 'Drug-Related Side Effects and Adverse Reactions-controlled-Pain', 'Neoplasms-assessed-Cancer Pain', 'Heart Failure-seem-Myocardial Infarction', 'Necrosis-play-Heart Failure', 'Heart Failure-show-Ventricular Remodeling', 'Anemia-classified-Malnutrition', 'Anemia-classified-Inflammation', 'Anemia-classified-Kidney Diseases', 'Obesity, Abdominal-evaluate-Colorectal Neoplasms', 'Hyperparathyroidism-suspect-Kidney Diseases', 'Hypertension-suffer-Diabetes Mellitus', 'Back Pain-predict-Erectile Dysfunction', 'Diabetes Mellitus-predict-Erectile Dysfunction', 'Diabetes Mellitus-evaluated-Erectile Dysfunction', 'Diabetic Nephropathies-account-Retinal Diseases', 'Diabetic Nephropathies-account-Cerebrovascular Disorders', 'Heart Injuries-limit-Cardiomyopathies', 'Inflammation-depend-Chronic Disease', 'Hypertension-suffering-Coronary Artery Disease', 'Diabetes Mellitus-suffering-Coronary Artery Disease', 'Death-dissect-Aortic Aneurysm', 'Cardiovascular Diseases-dissect-Aortic Aneurysm', 'Coronary Artery Disease-dissect-Aortic Aneurysm', 'Aortic Aneurysm-dissect-Stroke', 'Parkinson Disease-develop-Alzheimer Disease', 'Parkinson Disease-develop-Dementia, Vascular', 'Parkinson Disease-experience-Hallucinations', 'Hallucinations-experience-Parkinson Disease', 'Delirium-characterized-Psychomotor Agitation', 'Delirium-characterized-Hallucinations', 'Lipomatosis-defined-Pancreatitis', 'Rheumatic Diseases-used-Fever', 'Lipomatosis-associated-Myelodysplastic Syndromes', 'Myelodysplastic Syndromes-associated-Lipomatosis', 'Lipomatosis-cause-Pancreatic Neoplasms', 'Fractures, Bone-compare-Muscular Dystrophy, Duchenne', 'Hypertension-predict-Alzheimer Disease', 'Hypercholesterolemia-predict-Alzheimer Disease', 'Dementia-influenced-Obesity', 'Hypertrophy, Left Ventricular-take-Cardiovascular Diseases', 'Hypertrophy, Left Ventricular-happen-Hypertension', 'Cardiovascular Diseases-take-Stroke', 'Cardiovascular Diseases-take-Renal Insufficiency', 'Cardiovascular Diseases-take-Dementia', 'Stroke-happen-Hypertension', 'Renal Insufficiency-happen-Hypertension', 'Dementia-happen-Hypertension', 'Leukemia, Myeloid-increasing-Neoplasms', 'Supranuclear Palsy, Progressive-characterized-Nerve Degeneration', 'Myelodysplastic Syndromes-treated-Neoplasms', 'Supranuclear Palsy, Progressive-characterized-Gliosis', 'Coronary Artery Disease-reduce-Constriction, Pathologic', 'Coronary Artery Disease-reduce-Atherosclerosis', 'Atherosclerosis-protect-Coronary Artery Disease', 'Retinal Vein Occlusion-use-Vision Disorders', 'Seizures-promote-Weight Loss', 'Diabetic Nephropathies-lead-Renal Insufficiency', 'Diabetic Nephropathies-cause-Diabetes Mellitus', 'Renal Insufficiency-cause-Diabetes Mellitus', 'Diabetes Mellitus-burdened-Foot Diseases', 'Diabetic Foot-apply-Diabetes Mellitus', 'Stroke-become-Dementia', 'Genetic Diseases, Inborn-impact-Lung Injury', 'Pulmonary Disease, Chronic Obstructive-get-Emphysema', 'Inflammation-acquire-Asthma', 'Takotsubo Cardiomyopathy-characterized-Chest Pain', 'Takotsubo Cardiomyopathy-mimic-Myocardial Infarction', 'Chest Pain-mimic-Myocardial Infarction', 'Myocardial Infarction-mimic-Takotsubo Cardiomyopathy', 'Fatigue-minimized-Ischemia', 'Ankle Injuries-perform-Reperfusion Injury', 'Fatigue-fatigue-Ischemia', 'Stroke-use-Seizures', 'Death-use-Seizures', 'Arthritis-report-Pain', 'Neoplasms-induce-Drug-Related Side Effects and Adverse Reactions', 'Nerve Degeneration-induce-Neuroblastoma', 'Obesity-change-Lymphedema', 'Neoplasms-change-Lymphedema', 'Breast Neoplasms-serve-Lymphedema', 'Adrenocortical Hyperfunction-misinterpreted-Fatigue', 'Lymphohistiocytosis, Hemophagocytic-associated-Infections', 'Infections-associated-Lymphohistiocytosis, Hemophagocytic', 'Lymphoma-associated-Lymphohistiocytosis, Hemophagocytic', 'Lymphohistiocytosis, Hemophagocytic-associated-Lymphoma', 'Adrenocortical Hyperfunction-occur-Paralysis', 'Paralysis-occur-Wounds and Injuries', 'Breast Neoplasms-compared-Neoplasms', 'Parkinson Disease-considered-Disease', 'Hypertension-diagnosed-Tachycardia, Atrioventricular Nodal Reentry', 'Diabetes Mellitus-diagnosed-Tachycardia, Atrioventricular Nodal Reentry', 'Coronary Artery Disease-diagnosed-Tachycardia, Atrioventricular Nodal Reentry', 'Tachycardia, Atrioventricular Nodal Reentry-reported-Dyspnea', 'Tachycardia, Atrioventricular Nodal Reentry-reported-Chest Pain', 'Tachycardia, Atrioventricular Nodal Reentry-reported-Syncope', 'Osteoporosis-describe-Fractures, Bone', 'Pain-describe-Fractures, Bone', 'Fractures, Bone-include-Pelvic Neoplasms', 'Kidney Diseases-include-Glomerulonephritis', 'Kidney Diseases-include-Fibrosis', 'Hemangioblastoma-occur-Pain', 'Hemangioblastoma-occur-Radiculopathy', 'Alzheimer Disease-occur-Hypertension', 'Cerebral Hemorrhage-exclude-Cerebral Infarction', 'Bronchitis-linked-Infections', 'Pulmonary Disease, Chronic Obstructive-underlie-Bronchitis', 'Splenic Diseases-analyzed-Wounds and Injuries', 'Mitochondrial Diseases-lead-Vision Disorders', 'Xanthomatosis, Cerebrotendinous-reported-Drug-Related Side Effects and Adverse Reactions', 'Nausea-include-Signs and Symptoms, Digestive', 'Pain-include-Signs and Symptoms, Digestive', 'Vomiting-include-Signs and Symptoms, Digestive', 'Cough-include-Signs and Symptoms, Digestive', 'Weight Loss-include-Signs and Symptoms, Digestive', 'Deglutition Disorders-include-Signs and Symptoms, Digestive', 'Hypertrophy, Left Ventricular-translate-Arrhythmias, Cardiac', 'Nausea-include-Gastroesophageal Reflux', 'Pain-include-Gastroesophageal Reflux', 'Vomiting-include-Gastroesophageal Reflux', 'Cough-include-Gastroesophageal Reflux', 'Hypertrophy, Left Ventricular-translate-Myocardial Infarction', 'Weight Loss-include-Gastroesophageal Reflux', 'Deglutition Disorders-include-Gastroesophageal Reflux', 'Hypertrophy, Left Ventricular-translate-Glucose Intolerance', 'Hypertrophy, Left Ventricular-translate-Death', 'Arrhythmias, Cardiac-translate-Death', 'Myocardial Infarction-translate-Death', 'Glucose Intolerance-translate-Death', 'Constipation-associated-Gastroesophageal Reflux', 'Gastroesophageal Reflux-associated-Constipation', 'Angina Pectoris-predict-Death', 'Hyperinsulinism-associated-Alzheimer Disease', 'Alzheimer Disease-associated-Hyperinsulinism', 'Hyperinsulinism-associated-Dementia', 'Dementia-associated-Hyperinsulinism', 'Hyperinsulinism-associated-Stroke', 'Stroke-associated-Hyperinsulinism', 'Diabetes Mellitus-use-Metabolic Syndrome', 'Hyperinsulinism-use-Metabolic Syndrome', 'Neurodegenerative Diseases-reverse-Nerve Degeneration', 'Blepharitis-occur-Cataract', 'Sinusitis-noted-Polyps', 'Aneurysm-include-Infections', 'Neuroblastoma-employ-Nerve Degeneration', 'Metabolic Syndrome-require-Diabetes Mellitus', 'Tibial Meniscus Injuries-occur-Necrosis', 'Constriction, Pathologic-developed-Hernia', 'Neoplasms-redirect-Graft vs Host Disease', 'Autoimmune Diseases-redirect-Graft vs Host Disease', 'Immunologic Deficiency Syndromes-redirect-Graft vs Host Disease', 'Arthritis-contribute-Spinal Stenosis', 'Hypertrophy-contribute-Spinal Stenosis', 'Spinal Stenosis-provide-Pain', 'Neoplasms-represented-Sarcoma', 'Neoplasms-contain-Hyperplasia', 'Retinal Detachment-assumed-Cardiovascular Diseases', 'Carcinoma, Non-Small-Cell Lung-identified-Heart Arrest', 'Signs and Symptoms, Respiratory-included-Pulmonary Aspergillosis', 'Drug Hypersensitivity-defined-Pain', 'Heart Diseases-considered-Neoplasms', 'Heart Diseases-considered-Death', 'Neoplasms-inhibit-X-Linked Combined Immunodeficiency Diseases', 'Heart Diseases-considered-Heart Failure', 'Hypotension, Orthostatic-defined-Hypotension', 'Obesity-associated-Malnutrition', 'Malnutrition-associated-Obesity', 'Acquired Immunodeficiency Syndrome-include-Infections', 'Syncope-influence-Death', 'Prion Diseases-belong-Neurodegenerative Diseases', 'Osteoporosis-affected-Progeria', 'Osteoporosis-affected-Dementia, Vascular', 'Progeria-uncovered-Cardiovascular Diseases', 'Progeria-affected-Dementia, Vascular', 'Progeria-range-Arrhythmias, Cardiac', 'Dementia, Vascular-lead-Stroke', 'Cardiovascular Diseases-range-Arrhythmias, Cardiac', 'Ophthalmoplegia-decrease-Retinal Vein Occlusion', 'Death-appear-Immunologic Deficiency Syndromes', 'Infections-resolve-Colitis', 'Hip Fractures-considered-Osteoporotic Fractures', 'Hip Fractures-lead-Back Pain', 'Hip Fractures-lead-Kyphosis', 'Fractures, Bone-lead-Back Pain', 'Diarrhea-resolve-Cardiomyopathy, Dilated', 'Bone Neoplasms-diagnose-Osteoporosis', 'Bone Neoplasms-experience-Fractures, Bone', 'Hypertension-placed-Sleep Apnea Syndromes', 'Hypertension-placed-Heart Failure', 'Diabetes Mellitus-placed-Sleep Apnea Syndromes', 'Diabetes Mellitus-placed-Heart Failure', 'Myalgia-associated-Neurodegenerative Diseases', 'Neurodegenerative Diseases-associated-Myalgia', 'Dementia-explained-Headache', 'Cardiovascular Diseases-escape-Atherosclerosis', 'Weight Loss-suffer-Musculoskeletal Diseases', 'Ovarian Neoplasms-removed-Disease', 'Hypertension-present-Collagen Diseases', 'Fistula-associated-Atherosclerosis', 'Atherosclerosis-associated-Fistula', 'Fistula-associated-Hypertension', 'Hypertension-associated-Fistula', 'Fistula-associated-Collagen Diseases', 'Collagen Diseases-associated-Fistula', 'Hypertension-associated-Leukoaraiosis', 'Leukoaraiosis-associated-Hypertension', 'Diabetes Mellitus-implicated-Renal Insufficiency', 'Diabetes Mellitus-implicated-Fibrosis', 'Diabetes Mellitus-implicated-Arthritis', 'Psychoses, Substance-Induced-include-Headache Disorders, Secondary', 'Myocardial Infarction-assessed-Death', 'Hypotension-show-Hypertrophy, Left Ventricular', 'Cardiac Output, Low-result-Alzheimer Disease', 'Cardiac Output, Low-result-Dementia', 'Neoplasms-occur-Cell Transformation, Neoplastic', 'Neurodegenerative Diseases-present-Death', 'Bone Resorption-observed-Bone Diseases', 'Bone Neoplasms-found-Osteoporotic Fractures', 'Endocrine System Diseases-involved-Osteoporosis', 'Osteoporosis-protect-Fractures, Bone', 'Alzheimer Disease-prevent-Learning Disabilities', 'Tauopathies-reduce-Neurodegenerative Diseases', 'Tauopathies-prevent-Learning Disabilities', 'Neurodegenerative Diseases-prevent-Learning Disabilities', 'Drug Hypersensitivity-proposed-Coronary Restenosis', 'Colorectal Neoplasms-diagnosed-Osteoarthritis', 'Heart Failure-complete-Death', 'Nephrosis, Lipoid-used-Death', 'Arteriosclerosis-achieve-Cardiovascular Diseases', 'Seizures-achieve-Cardiovascular Diseases', 'Diabetes Mellitus-used-Hyperkalemia', 'Kidney Diseases-used-Hyperkalemia', 'Stroke-include-Subarachnoid Hemorrhage', 'Subarachnoid Hemorrhage-include-Cerebral Infarction', 'Cerebral Hemorrhage-include-Cerebral Infarction', 'Stroke-tend-Cerebral Infarction', 'Hypercholesterolemia-associated-Hypertension', 'Hypertension-associated-Hypercholesterolemia', 'Death-stratify-Diabetes Mellitus', 'Sleepiness-reflect-Psychomotor Disorders', 'Sleep Initiation and Maintenance Disorders-reduce-Sleep Wake Disorders', 'Sleep Initiation and Maintenance Disorders-reduce-Sleepiness', 'Xerostomia-cover-Hantavirus Pulmonary Syndrome', 'Bone Diseases, Metabolic-result-Fractures, Bone', 'Hypogonadism-predisposed-Osteoporosis', 'Hyperemia-related-Oculocerebrorenal Syndrome', 'Hyperemia-related-Infertility, Female', 'Osteoporotic Fractures-improve-Fractures, Bone', 'Death-lead-Ischemia', 'Aneurysm-exist-Atherosclerosis', 'Constipation-cause-Pain', 'Wounds and Injuries-lead-Pain', 'Weight Loss-targeted-Inflammation', 'Weight Loss-bear-Cardiovascular Diseases', 'Inflammation-bear-Cardiovascular Diseases', 'Carcinoma, Merkel Cell-distinguished-Lung Neoplasms', 'Carcinoma, Merkel Cell-distinguished-Small Cell Lung Carcinoma', 'Carcinoma, Merkel Cell-distinguished-Melanoma', 'Diabetes Mellitus-examine-Parkinsonian Disorders', 'Diabetes Mellitus-associated-Parkinsonian Disorders', 'Parkinsonian Disorders-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-Hypokinesia', 'Hypokinesia-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-Muscle Rigidity', 'Muscle Rigidity-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-Tremor', 'Tremor-associated-Diabetes Mellitus', 'Intervertebral Disc Degeneration-manifested-Neck Pain', 'Dementia-recognized-Parkinson Disease', 'Infertility, Female-increase-Heart Failure', 'Hypoxia-related-Respiratory Insufficiency', 'Hypoxia-related-Sleep Apnea Syndromes', 'Hypoxia-related-Pulmonary Disease, Chronic Obstructive', 'Hypoxia-related-Diabetes Mellitus', 'Hypoxia-related-Hypertension', 'Hypoxia-related-Arteriosclerosis', 'Spondylosis-compared-Liver Neoplasms', 'Spinal Cord Diseases-compared-Liver Neoplasms', 'Fractures, Bone-compared-Liver Neoplasms', 'Pneumonia-evaluate-Death', 'Osteoarthritis-followed-Arthritis', 'Pneumonia-peak-Malaria', 'Atrial Fibrillation-show-Death', 'Fractures, Bone-yield-Hypotension', 'Parkinsonian Disorders-include-Muscle Rigidity', 'Parkinsonian Disorders-include-Hypokinesia', 'Parkinsonian Disorders-include-Tremor', 'Muscular Atrophy-vary-Pain', 'Muscular Atrophy-correlate-Pain', 'Goldenhar Syndrome-develop-Osteoarthritis', 'Death-vary-Aortic Aneurysm, Abdominal', 'Ischemia-effected-Coronary Occlusion', 'Lymphoma-cause-Neurotoxicity Syndromes', 'Ventricular Remodeling-describe-Arrhythmogenic Right Ventricular Dysplasia', 'Ventricular Remodeling-describe-Myocardial Infarction', 'Ventricular Remodeling-describe-Ischemia', 'Glucose Metabolism Disorders-demonstrated-Alzheimer Disease', 'Alzheimer Disease-demonstrated-Glucose Metabolism Disorders', 'Alzheimer Disease-compare-Glucose Metabolism Disorders', 'Glucose Metabolism Disorders-reduce-Alzheimer Disease', 'Atrial Fibrillation-directed-Thromboembolism', 'Constipation-predate-Parkinson Disease', 'Genetic Diseases, Inborn-characterized-Lipodystrophy', 'Cardiac Output, Low-fall-Arthritis', 'Cardiac Output, Low-fall-Asthma', 'Neoplasms-increase-Carcinogenesis', 'Infections-suggest-Immunologic Deficiency Syndromes', 'Metabolic Diseases-play-Neoplasms', 'Bone Diseases, Metabolic-related-Bone Diseases', 'Bone Diseases, Metabolic-related-Diabetes Mellitus', 'Acute Kidney Injury-linked-Death', 'Renal Insufficiency, Chronic-result-Kidney Diseases', 'Pancreatitis-followed-Pancreatitis, Chronic', 'Autoimmune Pancreatitis-seem-Pancreatitis, Chronic', 'Pancreatitis, Chronic-followed-Exocrine Pancreatic Insufficiency', 'Autoimmune Pancreatitis-develop-Neoplasms', 'Tremor-develop-Dementia', 'Leukemia-account-Leukemia, Lymphocytic, Chronic, B-Cell', 'Diabetes Mellitus-associated-Glomerulosclerosis, Focal Segmental', 'Glomerulosclerosis, Focal Segmental-associated-Diabetes Mellitus', 'Glomerulosclerosis, Focal Segmental-associated-Erectile Dysfunction', 'Erectile Dysfunction-associated-Glomerulosclerosis, Focal Segmental', 'Ossification of Posterior Longitudinal Ligament-associated-Hypertension', 'Hypertension-associated-Ossification of Posterior Longitudinal Ligament', 'Autoimmune Diseases-include-Leukemia', 'Parkinson Disease-develop-Vision Disorders', 'Fractures, Bone-expected-Death', 'Death-examined-Neoplasms', 'Infarction-form-Alzheimer Disease', 'Alzheimer Disease-increase-Infarction', 'Diabetes Mellitus-compared-Death', 'Diabetes Mellitus-compared-Kidney Diseases', 'Diabetes Mellitus-compared-Retinal Diseases', 'Diabetes Mellitus-compared-Cardiovascular Diseases', 'Diabetes Mellitus-compared-Cerebrovascular Disorders', 'Diabetes Mellitus-diagnosed-Heart Failure', 'Weight Loss-categorized-Sarcopenia', 'Weight Loss-categorized-Cachexia', 'Cachexia-recognized-Neoplasms', 'Cachexia-recognized-Immunologic Deficiency Syndromes', 'Cachexia-accompany-Immunologic Deficiency Syndromes', 'Intervertebral Disc Degeneration-implicate-Low Back Pain', 'Pneumonia-predict-Pneumococcal Infections', 'Hypoxia-involve-Retinal Degeneration', 'Ovarian Neoplasms-derived-Ovarian Diseases', 'Hepatitis E-show-Infections', 'Ventricular Dysfunction, Left-aimed-Heart Failure', 'Hepatitis E-investigate-Chemical and Drug Induced Liver Injury', 'Diabetes Mellitus-hold-Neoplasms', 'Dementia-hold-Neoplasms', 'Neuralgia-occur-Exanthema', 'Pain-described-Pruritus', 'Pain-burn-Pruritus', 'Exanthema-described-Pruritus', 'Exanthema-burn-Pruritus', 'Parkinson Disease-lead-Neurodegenerative Diseases', 'Huntington Disease-lead-Neurodegenerative Diseases', 'Glucose Metabolism Disorders-include-Aortic Diseases', 'Intracranial Aneurysm-present-Digestive System Neoplasms', 'Coronary Artery Disease-subdivided-Metabolic Syndrome', 'Coronary Artery Disease-correlated-Metabolic Syndrome', 'Coronary Artery Disease-predict-Metabolic Syndrome', 'Diabetes Mellitus-needed-Hyperglycemia', 'Diabetes Mellitus-needed-Hypertension', 'Diabetes Mellitus-needed-Dyslipidemias', 'Precursor Cell Lymphoblastic Leukemia-Lymphoma-associate-Hypotension', 'Hypotension-associate-Precursor Cell Lymphoblastic Leukemia-Lymphoma', 'Fractures, Bone-include-Kyphosis', 'Paralysis-associated-Pneumonia, Aspiration', 'Pneumonia, Aspiration-associated-Paralysis', 'Paralysis-develop-Pneumonia, Aspiration', 'Death-observed-Respiratory System Abnormalities', 'Death-observed-Respiratory Tract Diseases', 'Death-observed-Communicable Diseases', 'Colonic Neoplasms-include-Diverticulum, Colon', 'Ocular Motility Disorders-include-Diverticulum, Colon', 'Ocular Motility Disorders-include-Colonic Neoplasms', 'Inflammation-implicated-Neoplasms', 'Inflammation-implicated-Arthritis', 'Hyperglycemia-increase-Retinal Diseases', 'Hypertension-seen-Infections', 'Communicable Diseases-include-Back Pain', 'Glaucoma-tested-Vision Disorders', 'Inflammation-use-Atherosclerosis', 'Hypogonadism-include-Sarcopenia', 'Immunologic Deficiency Syndromes-cause-Severe Acute Respiratory Syndrome', 'Cardiomyopathies-related-Heart Failure', 'Glioblastoma-develop-Astrocytoma', 'Weight Gain-improve-Cardiovascular Diseases', 'Diabetes Mellitus-characterized-Urinary Bladder Diseases', 'Diabetes Mellitus-predict-Urinary Bladder Diseases', 'Obesity-conclude-Osteoarthritis', 'Autonomic Nervous System Diseases-predict-Urinary Bladder Diseases', 'Retinal Diseases-predict-Urinary Bladder Diseases', 'Jaw, Edentulous-associated-Hypoalbuminemia', 'Hypoalbuminemia-associated-Jaw, Edentulous', 'Respiratory Insufficiency-associated-Cerebrovascular Disorders', 'Cerebrovascular Disorders-associated-Respiratory Insufficiency', 'Gallstones-account-Intestinal Obstruction', 'Gallstones-diagnosed-Short Bowel Syndrome', 'Intestinal Fistula-diagnosed-Gallstones', 'Dementia-include-Hip Fractures', 'Leukoencephalopathies-increase-Hypertension', 'Encephalitis-offset-Hypothalamic Neoplasms', 'Hip Fractures-detect-Delirium', 'Sleep Initiation and Maintenance Disorders-lead-Sleep Wake Disorders', 'Neurologic Manifestations-require-Embolism', 'Neurologic Manifestations-require-Ischemia', 'Neurologic Manifestations-produced-Arterial Occlusive Diseases', 'Embolism-restricted-Ischemia', 'Embolism-restricted-Arterial Occlusive Diseases', 'Embolism-produced-Arterial Occlusive Diseases', 'Ischemia-produced-Arterial Occlusive Diseases', 'Embolism-fall-Inflammation', 'Embolism-fall-Demyelinating Diseases', 'Embolism-fall-Basal Ganglia Diseases', 'Craniocerebral Trauma-carry-Death', 'Erectile Dysfunction-reported-Diabetes Mellitus', 'Erectile Dysfunction-reported-Obesity', 'Erectile Dysfunction-reported-Hypertension', 'Neoplasms-continue-Breast Neoplasms', 'Hyperalgesia-associated-Death', 'Death-associated-Hyperalgesia', 'Epilepsy-lead-Dementia', 'Dementia-diagnosed-Malocclusion', 'Dementia-undergo-Nervous System Diseases', 'Malocclusion-undergo-Nervous System Diseases', 'Nerve Degeneration-occur-Status Epilepticus', 'Status Epilepticus-divided-Coma', 'Seizures-underlie-Atrophy', 'Migraine Disorders-associated-Epilepsy', 'Epilepsy-associated-Migraine Disorders', 'Migraine Disorders-mimic-Epilepsy', 'Infections-associated-Epilepsy', 'Epilepsy-associated-Infections', 'Infections-mimic-Epilepsy', 'Metabolic Diseases-associated-Epilepsy', 'Epilepsy-associated-Metabolic Diseases', 'Metabolic Diseases-mimic-Epilepsy', 'Sleep Wake Disorders-associated-Epilepsy', 'Epilepsy-associated-Sleep Wake Disorders', 'Sleep Wake Disorders-mimic-Epilepsy', 'Stroke-cause-Status Epilepticus', 'Hereditary Angioedema Type III-cause-Muscular Disorders, Atrophic', 'Death-complicated-Respiratory Insufficiency', 'Status Epilepticus-associated-Cerebral Infarction', 'Cerebral Infarction-associated-Status Epilepticus', 'Status Epilepticus-associated-Stroke', 'Stroke-associated-Status Epilepticus', 'Macular Degeneration-include-Onychomycosis', 'Peripheral Vascular Diseases-include-Onychomycosis', 'Diabetes Mellitus-include-Onychomycosis', 'Headache Disorders, Secondary-disposed-Nocturia', 'Diabetes Mellitus-treated-Onychomycosis', 'Diabetes Mellitus-prevent-Infections', 'Onychomycosis-prevent-Infections', 'Osteoporosis-strike-Arthritis', 'Osteoporosis-strike-Autoimmune Diseases', 'Osteoporosis-strike-HIV Infections', 'AIDS Dementia Complex-accelerate-Alzheimer Disease', 'Alzheimer Disease-relate-Hyperinsulinism', 'Obesity-increasing-Alzheimer Disease', 'Metabolic Syndrome-comprised-Obesity, Abdominal', 'Metabolic Syndrome-comprised-Hypertriglyceridemia', 'Metabolic Syndrome-include-Hypertriglyceridemia', 'Metabolic Syndrome-comprised-Hypertension', 'Metabolic Syndrome-comprised-Hyperglycemia', 'Metabolic Syndrome-include-Hyperglycemia', 'Inflammation-include-Metabolic Syndrome', 'Obesity-used-Dwarfism, Pituitary', 'Kidney Diseases-range-Death', 'Death-range-Liver Diseases', 'Death-range-Polycystic Kidney Diseases', 'Fibromyalgia-associated-Central Nervous System Diseases', 'Central Nervous System Diseases-associated-Fibromyalgia', 'Bone Diseases, Metabolic-predict-Osteoporosis', 'Drug Hypersensitivity-include-Respiratory Tract Diseases', 'Drug Hypersensitivity-include-Urticaria', 'Drug Hypersensitivity-include-Anaphylaxis', 'Respiratory Insufficiency-contribute-Heart Failure', 'Anaphylaxis-bring-Coronary Artery Disease', 'Hemorrhage-considered-Metabolic Diseases', 'Hemorrhage-use-Drug Hypersensitivity', 'Metabolic Diseases-use-Drug Hypersensitivity', 'Delirium-develop-Pressure Ulcer', 'Memory Disorders-reflect-Language Disorders', 'Memory Disorders-stemm-Language Disorders', 'Frontotemporal Lobar Degeneration-reflect-Language Disorders', 'Frontotemporal Lobar Degeneration-stemm-Language Disorders', 'Inflammation-experience-Fractures, Bone', 'Neoplasms-compliment-Atherosclerosis', 'Neoplasms-compliment-Heredodegenerative Disorders, Nervous System', 'Atherosclerosis-include-Neoplasms', 'Heredodegenerative Disorders, Nervous System-include-Neoplasms', 'Inflammation-extend-Fractures, Bone', 'Inflammation-extend-Osteoporotic Fractures', 'Death-attained-Diabetes Mellitus', 'Atrophy-characterized-Dementia, Vascular', 'Atrophy-observe-Alzheimer Disease', 'Alzheimer Disease-observe-Cerebral Small Vessel Diseases', 'Neurodegenerative Diseases-characterized-Dementia, Vascular', 'Alzheimer Disease-characterized-Dementia, Vascular', 'Alzheimer Disease-decline-Dementia', 'Anemia-occur-Neoplasms', 'Neutropenia-include-Thrombocytopenia', 'Neutropenia-include-Anemia', 'Hypertension-avoid-Weight Loss', 'Pulmonary Disease, Chronic Obstructive-compare-Neoplasms', 'Obesity-check-Chronic Disease', 'Death-lead-Dementia', 'Ischemia-compare-Heart Failure', 'Heart Failure-treat-Ventricular Remodeling', 'Arthritis-characterized-Cartilage Diseases', 'Sleep Wake Disorders-seen-Alzheimer Disease', 'Ischemia-demonstrated-Postoperative Cognitive Complications', 'Werner Syndrome-rescue-Drug Hypersensitivity', 'Neoplasms-reported-Xeroderma Pigmentosum', 'Xeroderma Pigmentosum-reported-Carcinoma, Squamous Cell', 'Xeroderma Pigmentosum-reported-Carcinoma, Basal Cell', 'Xeroderma Pigmentosum-reported-Melanoma', 'Death-enhanced-Renal Insufficiency, Chronic', 'Xeroderma Pigmentosum-develop-Carcinoma, Squamous Cell', 'Cough-associated-Hernia', 'Hernia-associated-Cough', 'Cough-associated-Hernia, Inguinal', 'Hernia, Inguinal-associated-Cough', 'Hernia-associated-Hernia, Inguinal', 'Hernia, Inguinal-associated-Hernia', 'Cystic Fibrosis-compromised-Infections', 'Cystic Fibrosis-compromised-Exocrine Pancreatic Insufficiency', 'Cystic Fibrosis-compromised-Lung Diseases', 'Cystic Fibrosis-compromised-Diabetes Mellitus', 'Hernia, Inguinal-associated-Hernia, Hiatal', 'Hernia, Hiatal-associated-Hernia, Inguinal', 'Hernia, Inguinal-associated-Obesity', 'Obesity-associated-Hernia, Inguinal', 'beta-Thalassemia-result-Neurodegenerative Diseases', 'Epididymitis-investigate-Pain', 'Epididymitis-associated-Hernia', 'Hernia-associated-Epididymitis', 'Pain-associated-Hernia', 'Hernia-associated-Pain', 'Epididymitis-caused-Ischemia', 'Granuloma-include-Calcinosis', 'Hematoma-include-Calcinosis', 'Epididymitis-include-Calcinosis', 'Colorectal Neoplasms-follow-Neoplasms', 'Prostatic Neoplasms-follow-Neoplasms', 'Atrial Fibrillation-interrupt-Tachycardia', 'Shock-deliver-Ventricular Fibrillation', 'Colorectal Neoplasms-perform-Colonic Neoplasms', 'Colorectal Neoplasms-prescribe-Thromboembolism', 'Colonic Neoplasms-prescribe-Thromboembolism', 'Neoplasms-perform-Colonic Neoplasms', 'Neoplasms-prescribe-Thromboembolism', 'Pain-include-Whiplash Injuries', 'Pain-include-Osteosarcoma', 'Pain-include-Neurologic Manifestations', 'Death-mediated-Infections', 'Cardiovascular Diseases-studied-Death', 'Neoplasm Metastasis-increase-Mastocytosis, Systemic', 'Mitochondrial Diseases-described-Xeroderma Pigmentosum', 'Mitochondrial Diseases-described-Trichothiodystrophy Syndromes', 'Torsades de Pointes-exhibit-Heart Diseases', 'Spinocerebellar Ataxias-form-Neurodegenerative Diseases', 'Dementia-suffer-Stroke', 'Neoplasms-diagnose-Lymphangioma, Cystic', 'Liver Neoplasms-associated-Prostatic Neoplasms', 'Prostatic Neoplasms-associated-Liver Neoplasms', 'Dementia-prevent-Heart Diseases', 'Cerebral Hemorrhage-include-Hypertension', 'Cerebral Hemorrhage-include-Cerebrovascular Disorders', 'Cerebral Amyloid Angiopathy-needed-Hemorrhage', 'Leukoaraiosis-needed-Hemorrhage', 'Hypotension, Orthostatic-include-Heart Diseases', 'Heart Failure-associated-Parkinson Disease', 'Parkinson Disease-associated-Heart Failure', 'Parkinson Disease-associated-Central Nervous System Diseases', 'Central Nervous System Diseases-associated-Parkinson Disease', 'Hypertension-avoided-Diabetes Mellitus', 'Sacroiliitis-followed-Spondylitis', 'Ischemia-decrease-Heart Failure', 'Heredodegenerative Disorders, Nervous System-associated-Constipation', 'Constipation-associated-Heredodegenerative Disorders, Nervous System', 'Cerebral Palsy-associated-Constipation', 'Constipation-associated-Cerebral Palsy', 'Schistosomiasis-rule-Liver Diseases', 'Splenomegaly-considered-Schistosomiasis', 'Death-encourage-Hematologic Neoplasms', 'Abnormalities, Drug-Induced-reconstruct-Infections', 'Death-cause-Foodborne Diseases', 'Memory Disorders-discovered-Craniocerebral Trauma', 'Memory Disorders-discovered-Brain Ischemia', 'Headache-discovered-Craniocerebral Trauma', 'Headache-discovered-Brain Ischemia', 'Hyperglycemia-induce-Mitochondrial Diseases', 'Mitochondrial Diseases-favor-Rupture', 'Hypertriglyceridemia-induce-Mitochondrial Diseases', 'Rupture-result-Myocardial Infarction', 'Rupture-result-Stroke', 'Rupture-result-Ischemia', 'Mitochondrial Diseases-associated-Atherosclerosis', 'Atherosclerosis-associated-Mitochondrial Diseases', 'Heart Valve Diseases-include-Heart Diseases', 'Scimitar Syndrome-include-Heart Diseases', 'Ventricular Outflow Obstruction-include-Heart Diseases', 'Pulmonary Atresia-include-Heart Diseases', 'Lysosomal Storage Diseases-manifest-Neurodegenerative Diseases', 'Joint Diseases-affect-Low Back Pain', 'Bone Marrow Diseases-attributed-Infections', 'Hypertension-show-Stroke', 'Hypertension-show-Hypertrophy', 'Hypertension-show-Cardiovascular Diseases', 'Cardiac Output, Low-undergo-Hematoma, Subdural', 'Cardiac Output, Low-present-Hematoma, Subdural', 'Constipation-reconducted-Dementia', 'Brain Injuries, Traumatic-associated-Spinal Cord Injuries', 'Spinal Cord Injuries-associated-Brain Injuries, Traumatic', 'Werner Syndrome-associated-Atherosclerosis', 'Atherosclerosis-associated-Werner Syndrome', 'Aging, Premature-associated-Neoplasms', 'Neoplasms-associated-Aging, Premature', 'Aging, Premature-associated-Atherosclerosis', 'Atherosclerosis-associated-Aging, Premature', 'Syncope-considered-Cardiovascular Diseases', 'Syncope-denounce-Death', 'Syncope-denounce-Heart Diseases', 'Syncope-denounce-Stroke', 'Sleep Initiation and Maintenance Disorders-study-Dementia', 'Dementia-treat-Headache Disorders, Secondary', 'Dementia-treat-Psychomotor Agitation', 'Dementia-treat-Psychoses, Substance-Induced', 'Delirium-characterized-Sleep Initiation and Maintenance Disorders', 'Neoplasms-compare-Adenocarcinoma', 'Neoplasms-studied-Colorectal Neoplasms', 'Adenocarcinoma, Mucinous-share-Adenocarcinoma', 'Adenocarcinoma, Mucinous-play-Microsatellite Instability', 'Adenocarcinoma, Mucinous-play-Neoplasms', 'Adenocarcinoma-play-Microsatellite Instability', 'Adenocarcinoma-play-Neoplasms', 'Microsatellite Instability-play-Neoplasms', 'Polycystic Ovary Syndrome-confirmed-Infertility, Female', 'Polycystic Ovary Syndrome-confirmed-Hirsutism', 'Hypothyroidism-needed-Thyroid Neoplasms', 'Neoplasms-diagnose-Pleural Effusion, Malignant', 'Anemia-raise-Neoplasms', 'Cerebral Infarction-estimated-Heart Failure', 'Cerebral Infarction-estimated-Hypertension', 'Cerebral Infarction-estimated-Diabetes Mellitus', 'Cerebral Infarction-estimated-Stroke', 'Cerebral Infarction-estimated-Ischemia', 'Neoplasms-known-Adrenal Insufficiency', 'Neoplasms-investigated-Hereditary Breast and Ovarian Cancer Syndrome', 'Hereditary Breast and Ovarian Cancer Syndrome-known-Adrenal Insufficiency', 'Hereditary Breast and Ovarian Cancer Syndrome-use-Death', 'Neoplasms-seen-Genetic Diseases, Inborn', 'Cardiovascular Diseases-extend-Dementia', 'Muscular Diseases-associated-Disease', 'Disease-associated-Muscular Diseases', 'Atrophy-associated-Disease', 'Disease-associated-Atrophy', 'Muscular Dystrophies-present-Deglutition Disorders', 'Muscular Dystrophies-present-Muscle Weakness', 'Muscular Diseases-present-Deglutition Disorders', 'Brain Injury, Chronic-associated-Alzheimer Disease', 'Alzheimer Disease-associated-Brain Injury, Chronic', 'Hepatitis C-show-Chemical and Drug Induced Liver Injury', 'Aneuploidy-reported-Prostatic Neoplasms', 'Aneuploidy-reported-Hematologic Neoplasms', 'Aneuploidy-study-Prostatic Neoplasms', 'Aneuploidy-study-Hyperplasia', 'Obesity-associated-Cataract', 'Cataract-associated-Obesity', 'Obesity-associated-Aphakia', 'Aphakia-associated-Obesity', 'Inflammation-associated-Gastrointestinal Diseases', 'Gastrointestinal Diseases-associated-Inflammation', 'Hypertension-cause-Sleep Deprivation', 'Death-followed-Neoplasms', 'Colorectal Neoplasms-followed-Death', 'Neoplasms-followed-Death', 'Colorectal Neoplasms-followed-Neoplasms', 'Lithiasis-examine-Choledocholithiasis', 'Death-quantify-Alzheimer Disease', 'Death-conducted-Cerebral Infarction', 'Ulcer-result-Gangrene', 'Infections-result-Gangrene', 'Amyotrophic Lateral Sclerosis-result-Gangrene', 'Peripheral Arterial Disease-result-Gangrene', 'Calcinosis-assessed-Osteoarthritis', 'Death-describe-Pneumonia', 'Pain-lead-Sleep Wake Disorders', 'Pain-lead-Malnutrition', 'Genetic Diseases, Inborn-characterized-Colorectal Neoplasms', 'Syncope-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-Syncope', 'Osteoporosis-induced-Hypogonadism', 'Syncope-distinguished-Shy-Drager Syndrome', 'Syncope-distinguished-Drug Hypersensitivity', 'Hypogonadism-induced-Prostatic Neoplasms', 'Syncope-distinguished-Hypotension', 'Syncope-distinguished-Nervous System Diseases', 'Cardiovascular Diseases-associated-Shy-Drager Syndrome', 'Shy-Drager Syndrome-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-Drug Hypersensitivity', 'Drug Hypersensitivity-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-Nervous System Diseases', 'Nervous System Diseases-associated-Cardiovascular Diseases', 'Neoplasms-followed-Respiratory Tract Diseases', 'Syncope-observed-Shock, Hemorrhagic', 'Shock, Hemorrhagic-observed-Paraneoplastic Endocrine Syndromes', 'Gastrointestinal Diseases-discussed-Infections', 'Gastrointestinal Diseases-discussed-Malabsorption Syndromes', 'Gastrointestinal Diseases-discussed-Diverticular Diseases', 'Gastrointestinal Diseases-discussed-Neoplasms', 'Musculoskeletal Diseases-result-Epilepsy, Absence', 'Fractures, Bone-reduce-Osteoporosis', 'Hip Fractures-reduce-Osteoporosis', 'Osteoporosis-yield-Fractures, Bone', 'Atherosclerosis-contribute-Death', 'Myocardial Infarction-contribute-Death', 'Alzheimer Disease-involved-Ovarian Diseases', 'Inflammation-associated-Prostatic Neoplasms', 'Prostatic Neoplasms-associated-Inflammation', 'Inflammation-associated-Carcinogenesis', 'Carcinogenesis-associated-Inflammation', 'Hypertension-occur-Cardiovascular Diseases', 'Fractures, Bone-divided-Pain', 'Fractures, Bone-function-Wounds and Injuries', 'Fractures, Bone-stratified-Pain', 'Wounds and Injuries-stratified-Pain', 'Waterborne Diseases-associated-Hypopituitarism', 'Hypopituitarism-associated-Waterborne Diseases', 'Death-caused-Subarachnoid Hemorrhage', 'Death-caused-Cerebrovascular Disorders', 'Stroke-measured-Death', 'Infections-facilitate-Fibrosis', 'Dementia-estimate-Alzheimer Disease', 'Cholelithiasis-include-Obesity', 'Acalculous Cholecystitis-associated-Wounds and Injuries', 'Wounds and Injuries-associated-Acalculous Cholecystitis', 'Acalculous Cholecystitis-associated-Multiple Organ Failure', 'Multiple Organ Failure-associated-Acalculous Cholecystitis', 'Death-give-Acalculous Cholecystitis', 'Hypotension-compare-Euthyroid Sick Syndromes', 'Lung Neoplasms-account-Death', 'Death-account-Colorectal Neoplasms', 'Adrenal Insufficiency-increase-Fractures, Bone', 'Paraplegia-anticipate-Cumulative Trauma Disorders', 'Coronary Artery Disease-caused-Mucocutaneous Lymph Node Syndrome', 'Tricuspid Valve Insufficiency-associated-Cardiomyopathy, Dilated', 'Cardiomyopathy, Dilated-associated-Tricuspid Valve Insufficiency', 'Neoplasms-predispose-Carcinogenesis', 'Multiple Organ Failure-considered-Drug-Related Side Effects and Adverse Reactions', 'Glaucoma, Open-Angle-reduce-Skin Neoplasms', 'Cough-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-Cough', 'Tuberculosis-result-Tuberculosis, Osteoarticular', 'Headache Disorders, Secondary-include-Dementia', 'Alzheimer Disease-lead-Diffuse Neurofibrillary Tangles with Calcification', 'Myositis-become-Acquired Immunodeficiency Syndrome', 'Chronic Disease-include-Peripheral Vascular Diseases', 'Chronic Disease-underlie-Diabetes Mellitus', 'Death-correspond-Shock, Septic', 'Heart Failure-directed-Ventricular Dysfunction', 'Heart Failure-identify-Ventricular Dysfunction', 'Death-require-Hyperkalemia', 'Alzheimer Disease-use-Melkersson-Rosenthal Syndrome', 'Gout-associate-Edema', 'Edema-associate-Gout', 'Gout-treat-Inflammation', 'Glucose Intolerance-lead-Obesity', 'Neoplasms-vary-Urinary Bladder Neoplasms', 'Peripheral Arterial Disease-associate-Intermittent Claudication', 'Intermittent Claudication-associate-Peripheral Arterial Disease', 'Peripheral Arterial Disease-cause-Ischemia', 'Intermittent Claudication-cause-Ischemia', 'Smoke Inhalation Injury-become-Death', 'Intermittent Claudication-increase-Hypercholesterolemia', 'Smoke Inhalation Injury-increase-Death', 'Smoke Inhalation Injury-predispose-Pneumonia', 'Death-predispose-Pneumonia', 'Pneumonia-shown-Death', 'Pneumonia-lead-Smoke Inhalation Injury', 'Death-lead-Smoke Inhalation Injury', 'Aneurysm-followed-Osteomyelitis', 'Renal Insufficiency-known-Kidney Diseases', 'Hypothyroidism-induced-Thyroid Neoplasms', 'Cardiovascular Diseases-followed-Diabetes Mellitus', 'Rheumatic Diseases-followed-Cardiovascular Diseases', 'Arthritis-followed-Cardiovascular Diseases', 'Diabetes Mellitus-followed-Rheumatic Diseases', 'Diabetes Mellitus-followed-Arthritis', 'Obesity-cause-Diabetes Mellitus', 'Down Syndrome-afflict-Infertility, Female', 'Sleep Wake Disorders-manifested-Fatigue', 'Pulmonary Disease, Chronic Obstructive-manifested-Fatigue', 'Hypoxia-diminish-Respiratory Insufficiency', 'Fractures, Bone-sustain-Wounds and Injuries', 'Leukemia-respond-Burkitt Lymphoma', 'Leukemia-give-Lymphoma, B-Cell', 'Burkitt Lymphoma-give-Lymphoma, B-Cell', 'Anemia-include-Gastrointestinal Hemorrhage', 'Atherosclerosis-related-Hepatitis E', 'Pain-suffer-Low Back Pain', 'Adenocarcinoma-identified-Death', 'Nervous System Diseases-lead-Spinal Cord Diseases', 'Ischemia-lead-Spinal Cord Diseases', 'Chemical and Drug Induced Liver Injury-increase-End Stage Liver Disease', 'Death-increased-Acute Kidney Injury', 'Death-increased-Sepsis', 'Death-develop-Infections', 'Acute Kidney Injury-develop-Infections', 'Fractures, Stress-applied-Osteoporosis', 'Chest Pain-simulate-Myocardial Infarction', 'Fractures, Stress-considered-Chest Pain', 'Fractures, Stress-considered-Myocardial Infarction', 'Fractures, Stress-considered-Pulmonary Embolism', 'Neoplasms-thought-Heart Arrest', 'Neoplasms-include-Genetic Diseases, Inborn', 'Hypothyroidism-reported-Alzheimer Disease', 'Alzheimer Disease-contribute-Hypothyroidism', 'Memory Disorders-cover-Dementia', 'Stroke-develop-Epilepsy', 'Seizures-develop-Epilepsy', 'Seizures-alter-Stroke', 'Stroke-base-Seizures', 'Stroke-demonstrate-Seizures', 'Neoplasm Metastasis-develop-Neurologic Manifestations', 'Pain-denied-Obesity', 'Pain-denied-Arthritis', 'Heart Failure-result-Cardiomyopathy, Dilated', 'Cardiomyopathy, Dilated-result-Genetic Diseases, Inborn', 'Obesity-affect-Cardiomegaly', 'Diabetes Mellitus-affect-Cardiomegaly', 'Heart Diseases-maintain-Ventricular Fibrillation', 'Heart Failure-indicate-Heart Diseases', 'Heart Failure-related-Hypotension', 'Osteoarthritis-observed-Coronary Artery Disease', 'Cardiac Output, Low-observed-Coronary Artery Disease', 'Cardiac Output, Low-fall-Osteoarthritis', 'Alzheimer Disease-considered-Genetic Diseases, Inborn', 'Neurodegenerative Diseases-considered-Genetic Diseases, Inborn', 'Hypertension-contribute-Aneurysm', 'Pain-administer-Pain Insensitivity, Congenital', 'Seizures-survive-Stroke', 'Stroke-constitute-Epilepsy', 'Hallucinations-present-Erectile Dysfunction', 'Tuberculosis-produce-Anemia', 'Anemia-associated-Tuberculosis', 'Tuberculosis-associated-Anemia', 'Tuberculosis-characterize-Anemia', 'Diabetes Mellitus-reduce-Hypotension', 'Hypotension-appear-Diabetes Mellitus', 'Leukemia, Myeloid, Acute-suffer-Leukemia', 'Alzheimer Disease-lack-Plaque, Amyloid', 'Aging, Premature-appear-Neoplasms', 'Cockayne Syndrome-lack-Neoplasms', 'Trichothiodystrophy Syndromes-lack-Neoplasms', 'Genetic Diseases, Inborn-give-Hypertension', 'Genetic Diseases, Inborn-give-Xeroderma Pigmentosum', 'Craniocerebral Trauma-short-Coma, Post-Head Injury', 'Craniocerebral Trauma-short-Neurologic Manifestations', 'Disease-associated-Hypertension', 'Hypertension-associated-Disease', 'Disease-associated-Hypercholesterolemia', 'Hypercholesterolemia-associated-Disease', 'Disease-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-Disease', 'Disease-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-Disease', 'Hypothalamic Diseases-expressed-Neuroblastoma', 'Tachycardia, Ventricular-avoid-Pain', 'Prostatic Hyperplasia-reduced-Hypotension', 'Cardiovascular Diseases-associated-Arterial Occlusive Diseases', 'Arterial Occlusive Diseases-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-Muscular Diseases', 'Muscular Diseases-associated-Cardiovascular Diseases', 'Pulmonary Disease, Chronic Obstructive-lower-Airway Obstruction', 'Uterine Hemorrhage-demonstrate-Neoplasms', 'Diabetes Mellitus-address-Obesity', 'Sleep Initiation and Maintenance Disorders-associated-Fatigue', 'Fatigue-associated-Sleep Initiation and Maintenance Disorders', 'Fever-report-Fatigue', 'Headache-report-Fatigue', 'Photophobia-report-Fatigue', 'Fatigue-indicate-Encephalitis, Tick-Borne', 'Fatigue-present-Acute Disease', 'Alzheimer Disease-control-Chronic Disease', 'Osteoporosis-suffer-Vascular Calcification', 'Osteoporosis-predict-Osteoporotic Fractures', 'Vascular Calcification-predict-Osteoporotic Fractures', 'Neurodegenerative Diseases-represent-Nerve Degeneration', 'Basal Ganglia Diseases-show-Parkinson Disease', 'Basal Ganglia Diseases-show-Learning Disabilities', 'Parkinson Disease-show-Learning Disabilities', 'Death, Sudden-applied-Parkinson Disease', 'Dyskinesia, Drug-Induced-considered-Parkinson Disease', 'Dyskinesia, Drug-Induced-assess-Parkinson Disease', 'Neoplasms-diagnosed-Neoplasm Invasiveness', 'Hemochromatosis-reduce-Drug-Related Side Effects and Adverse Reactions', 'Benign Paroxysmal Positional Vertigo-followed-Vertigo', 'Colorectal Neoplasms-undergo-Kidney Neoplasms', 'Headache Disorders, Secondary-undergo-Kidney Neoplasms', 'Paralysis-include-Femur Head Necrosis', 'Paralysis-include-Osteoarthritis, Hip', 'Infections-include-Femur Head Necrosis', 'Metabolic Syndrome-rise-Obesity', 'Neoplasms-suffer-Death', 'Drug-Related Side Effects and Adverse Reactions-associated-Renal Insufficiency', 'Renal Insufficiency-associated-Drug-Related Side Effects and Adverse Reactions', 'Pulmonary Disease, Chronic Obstructive-seem-Lung Neoplasms', 'Alzheimer Disease-protect-Neurotoxicity Syndromes', 'Myocardial Infarction-present-Shock', 'Coronary Artery Disease-present-Shock', 'Hypertension-present-Shock', 'Peripheral Vascular Diseases-present-Shock', 'Renal Insufficiency-present-Shock', 'Myocardial Infarction-result-Ventricular Dysfunction, Left', 'Myocardial Infarction-complicate-Heart Failure', 'Hypertension-coupled-Coronary Artery Disease', 'Heart Failure-impose-Death', 'Heart Failure-represent-Cardiovascular Diseases', 'Neurotoxicity Syndromes-lead-Atrophy', 'Kidney Diseases-lead-Hypertension', 'Hyperplasia-include-Prostatitis', 'Prostatic Intraepithelial Neoplasia-include-Prostatitis', 'Abdominal Pain-defined-Fever', 'Abdominal Pain-defined-Leukocytosis', 'Lordosis-associated-Spondylolysis', 'Spondylolysis-associated-Lordosis', 'Neuroma, Acoustic-found-Spondylolysis', 'Dementia-overlap-Alzheimer Disease', 'Communicable Diseases-control-Death', 'Pain-experience-Low Back Pain', 'Benign Paroxysmal Positional Vertigo-show-Vertigo', 'Benign Paroxysmal Positional Vertigo-show-Labyrinth Diseases', 'Inflammation-elicited-Infections', 'Tuberculosis-increasing-Acquired Immunodeficiency Syndrome', 'Tuberculosis-increasing-Substance-Related Disorders', 'Liver Abscess-associate-Infections', 'Infections-associate-Liver Abscess', 'Immunologic Deficiency Syndromes-exacerbate-Osteoporosis', 'Immunologic Deficiency Syndromes-cause-Osteomalacia', 'Muscular Atrophy-described-Liver Neoplasms', 'Multiple Sclerosis-contribute-Atrophy', 'Pain-indicated-Neurotoxicity Syndromes', 'Gallstones-increase-Pancreatitis', 'Death-present-Abdominal Pain', 'Short Bowel Syndrome-caused-Neoplasms', 'Dementia-increase-Stroke', 'Stroke-increase-Dementia, Vascular', 'Cerebrovascular Disorders-exacerbate-Alzheimer Disease', 'Epilepsy-focus-Seizures', 'Neoplasms-use-Leukemia', 'Metabolic Syndrome-lead-Drug-Related Side Effects and Adverse Reactions', 'Thyroid Diseases-contribute-Alzheimer Disease', 'Meibomian Gland Dysfunction-found-Dry Eye Syndromes', 'Neoplasms-produce-Colorectal Neoplasms', 'Learning Disabilities-request-Dementia', 'Pheochromocytoma-reduce-Neoplasms', 'Alcoholism-include-Osteoporosis', 'Blindness-include-Neurodegenerative Diseases', 'Death-decline-Infections', 'Neoplasms-decline-Infections', 'Diabetes Mellitus-decline-Infections', 'Myalgia-include-Polymyalgia Rheumatica', 'Pelvic Girdle Pain-include-Polymyalgia Rheumatica', 'Polymyalgia Rheumatica-expected-Inflammation', 'Pulmonary Disease, Chronic Obstructive-determined-Malocclusion', 'HIV Infections-increase-Pulmonary Disease, Chronic Obstructive', 'Atrophy-seen-Nervous System Diseases', 'Alzheimer Disease-precede-Atrophy', 'Anemia-excluded-Renal Insufficiency, Chronic', 'Chemical and Drug Induced Liver Injury-show-Hepatitis, Viral, Human', 'Hepatitis, Viral, Human-cause-Death', 'Anemia-worsen-Renal Insufficiency', 'Renal Insufficiency, Chronic-worsen-Renal Insufficiency', 'Hemorrhage-caused-Vasculitis', 'Myalgia-initiate-Obesity', 'Glomerulonephritis-observe-Kidney Failure, Chronic', 'Obesity-affect-Inflammation', 'Diabetic Nephropathies-related-Diabetes Mellitus, Type 2', 'Inflammation-affect-Obesity', 'Kidney Failure, Chronic-contribute-Death', 'Takotsubo Cardiomyopathy-involve-Hyperkinesis', 'Cardiomyopathies-added-Cardiomyopathy, Dilated', 'Death-reduce-Death, Sudden', 'Muscular Atrophy-result-Neuromuscular Diseases', 'Atrial Fibrillation-followed-Heart Failure', 'Heart Failure-followed-Heart Arrest', 'Angina Pectoris-approved-Angina, Stable', 'Intracranial Thrombosis-judged-Thrombosis', 'Metabolic Diseases-include-Alzheimer Disease', 'Prostatic Neoplasms-affected-Salivary Gland Diseases', 'Dementia-reduce-Death', 'Hemolytic-Uremic Syndrome-accumulated-Psychomotor Disorders', 'Bone Diseases-named-Renal Insufficiency, Chronic', 'Neoplasms-result-Carcinoma, Ovarian Epithelial', 'Stroke-associated-Multiple Sclerosis', 'Multiple Sclerosis-associated-Stroke', 'Cerebral Small Vessel Diseases-lead-Dementia, Vascular', 'Aneurysm-lead-Dementia, Vascular', 'Vascular Calcification-used-Coronary Artery Disease', 'Vascular Calcification-predict-Coronary Artery Disease', 'Vascular Calcification-associated-Coronary Artery Disease', 'Coronary Artery Disease-associated-Vascular Calcification', 'Heart Diseases-include-Myosarcoma', 'Fasciculation-include-Myosarcoma', 'Death, Sudden-include-Heart Diseases', 'Heart Failure-include-Heart Diseases', 'Lymphocytic Choriomeningitis-occur-Infections', 'Multiple Myeloma-occur-Cerebral Amyloid Angiopathy', 'Multiple Myeloma-show-Cerebral Amyloid Angiopathy', 'Multiple Myeloma-show-Dementia', 'Multiple Myeloma-show-Alzheimer Disease', 'Kidney Diseases-warrant-Osteoporosis', 'Kidney Diseases-associated-Osteoporotic Fractures', 'Osteoporotic Fractures-associated-Kidney Diseases', 'Fractures, Bone-confirm-Kidney Diseases', 'Coma-found-Death', 'Immunologic Deficiency Syndromes-name-Neoplasms', 'Parkinson Disease-become-Lysosomal Storage Diseases', 'Tetany-prevent-Death', 'Spinal Cord Injuries-include-Nervous System Diseases', 'Chemical and Drug Induced Liver Injury-caused-Drug Hypersensitivity', 'Sarcopenia-referred-Death', 'Sarcopenia-underlie-Muscular Diseases', 'Parkinson Disease-correspond-Candidiasis', 'Tuberculosis-facilitate-Liver Diseases', 'Infections-facilitate-Liver Diseases', 'Renal Insufficiency-undergo-Kidney Diseases', 'Renal Insufficiency-undergo-Nephrotic Syndrome', 'Glomerulonephritis-diagnosed-Nephrotic Syndrome', 'Kidney Diseases-diagnosed-Nephrotic Syndrome', 'Kidney Diseases-base-Nephrotic Syndrome', 'Kidney Diseases-present-Glomerulonephritis', 'Kidney Diseases-present-Renal Insufficiency', 'Glomerulonephritis-associated-Renal Insufficiency', 'Renal Insufficiency-associated-Glomerulonephritis', 'Acromegaly-associated-Headache Disorders, Secondary', 'Headache Disorders, Secondary-associated-Acromegaly', 'Cardiovascular Diseases-warrant-Diabetes Mellitus', 'Death-warrant-Diabetes Mellitus', 'Cardiovascular Diseases-become-Obesity', 'Atrial Fibrillation-recruited-Heart Failure', 'Heart Failure-determined-Atrial Fibrillation', 'Kidney Diseases-known-Obesity', 'Kidney Diseases-related-Obesity', 'Hallucinations-prevent-Cardiac Output, Low', 'Obesity-traced-Renal Insufficiency', 'Headache-include-Hematoma, Subdural', 'Headache-include-Herpes Zoster', 'Headache-include-Neoplasms', 'Arteritis-avoid-Vision Disorders', 'Stomach Neoplasms-associated-Inflammation', 'Inflammation-associated-Stomach Neoplasms', 'Stomach Neoplasms-associated-Tertiary Lymphoid Structures', 'Tertiary Lymphoid Structures-associated-Stomach Neoplasms', 'Diabetes Mellitus-related-Cerebrovascular Disorders', 'Diabetes Mellitus-underlie-Cerebrovascular Disorders', 'Sleep Initiation and Maintenance Disorders-contribute-Sleep Wake Disorders', 'Diabetes Mellitus-appear-Sleep Initiation and Maintenance Disorders', 'Gaucher Disease-compare-Death', 'Macular Degeneration-associated-Hearing Loss', 'Hearing Loss-associated-Macular Degeneration', 'Muscular Dystrophies, Limb-Girdle-defined-Communicable Diseases', 'Muscular Dystrophies, Limb-Girdle-defined-Muscle Weakness', 'Muscular Dystrophies, Limb-Girdle-defined-Pelvic Girdle Pain', 'Muscular Dystrophies, Limb-Girdle-affect-Musculoskeletal Diseases', 'Muscular Dystrophies, Limb-Girdle-affect-Signs and Symptoms, Digestive', 'Brain Injuries, Traumatic-activate-Inflammation', 'Brain Injuries, Traumatic-activate-Death', 'Brain Injuries, Traumatic-activate-Fibrosis', 'Leukemia-include-Leukemia, Myeloid, Acute', 'Leukemia, Promyelocytic, Acute-include-Leukemia, Myeloid, Acute', 'Encephalitis-respond-Lung Neoplasms', 'Alzheimer Disease-spread-Atrophy', 'Aortic Aneurysm, Abdominal-associated-Visceral Pain', 'Visceral Pain-associated-Aortic Aneurysm, Abdominal', 'Aortic Aneurysm, Abdominal-associated-Neoplasms', 'Neoplasms-associated-Aortic Aneurysm, Abdominal', 'Atherosclerosis-prevent-Myocardial Infarction', 'Hypertension-prevent-Myocardial Infarction', 'Urologic Diseases-defined-Urinary Incontinence', 'Urologic Diseases-defined-Nocturia', 'Urologic Diseases-recognize-Nocturia', 'Myocardial Infarction-prevent-Osteoporosis', 'Myocardial Infarction-prevent-Neoplasms', 'Myocardial Infarction-prevent-Obesity', 'Myocardial Infarction-prevent-Diabetes Mellitus', 'Dementia, Vascular-implicate-Dementia', 'Hyperhomocysteinemia-associated-Alzheimer Disease', 'Alzheimer Disease-associated-Hyperhomocysteinemia', 'Cystinuria-result-Nephrolithiasis', 'Genetic Diseases, Inborn-result-Nephrolithiasis', 'Death-included-Hypertension', 'Death-included-Hematologic Diseases', 'Death-included-Abnormalities, Drug-Induced', 'Death-included-Wounds and Injuries', 'Dementia-dominate-Alzheimer Disease', 'Muscular Dystrophy, Duchenne-contribute-Diabetic Neuropathies', 'Fractures, Bone-contribute-Diabetic Neuropathies', 'Death-caused-Hypertension', 'Death-caused-Obesity', 'Coronary Artery Disease-caused-Hypertension', 'Coronary Artery Disease-caused-Obesity', 'Cerebrovascular Disorders-caused-Hypertension', 'Cerebrovascular Disorders-caused-Obesity', 'Cardiovascular Diseases-used-Coronary Artery Disease', 'Diabetes Mellitus-suffer-Hypertension', 'Glucose Intolerance-suffer-Hypertension', 'Muscular Dystrophy, Duchenne-decrease-Fractures, Bone', 'Neoplasms, Multiple Primary-tend-Adenoma', 'Hypoalbuminemia-used-Malnutrition', 'Atrophy-show-Stomach Neoplasms', 'Olfaction Disorders-found-Parkinson Disease', 'Olfaction Disorders-precede-Parkinson Disease', 'Hearing Loss, Central-seen-Otosclerosis', 'Hearing Loss, Central-seen-Ankylosis', 'Sleep Initiation and Maintenance Disorders-associated-Psychomotor Disorders', 'Psychomotor Disorders-associated-Sleep Initiation and Maintenance Disorders', 'Neoplasms-cause-Appendicitis', 'Appendicitis-associated-Colorectal Neoplasms', 'Colorectal Neoplasms-associated-Appendicitis', 'Inflammation-involved-Communicable Diseases', 'Inflammation-represent-Metabolic Syndrome', 'Inflammation-represent-Diabetes Mellitus, Type 2', 'Death-address-Infections', 'Communicable Diseases-characterized-Metabolic Diseases', 'Perceptual Disorders-suggest-Alzheimer Disease', 'Death-derived-Alzheimer Disease', 'Inflammation-found-Atherosclerosis', 'Inflammation-fight-Infections', 'Immunologic Deficiency Syndromes-predisposed-Inflammation', 'Immunologic Deficiency Syndromes-affected-Communicable Diseases', 'Heart Diseases-linked-Periodontitis', 'Diabetes Mellitus-linked-Periodontitis', 'Arthritis, Rheumatoid-linked-Periodontitis', 'Cerebral Infarction-investigated-Stroke', 'Fractures, Bone-related-Seizures', 'Fractures, Bone-distributed-Osteoporotic Fractures', 'Epilepsy-distributed-Fractures, Bone', 'Epilepsy-distributed-Osteoporotic Fractures', 'Epilepsy-exacerbate-Osteoporosis', 'Musculoskeletal Diseases-derived-Ventricular Fibrillation', 'Dyspnea-develop-Pneumothorax', 'Acute Pain-challenge-Pain', 'Leukemia, Myeloid, Acute-considered-Bone Marrow Diseases', 'Heart Failure-differ-Heart Failure, Systolic', 'Heart Failure, Systolic-include-Heart Failure', 'Fractures, Bone-lead-Necrosis', 'Epilepsy-recur-Seizures', 'Brain Infarction-associated-Tremor', 'Tremor-associated-Brain Infarction', 'Leukoencephalopathies-associated-Tremor', 'Tremor-associated-Leukoencephalopathies', 'Atrophy-related-Muscle Rigidity', 'Atrophy-related-Hypokinesia', 'Inflammation-proposed-Alzheimer Disease', 'Inflammation-trigger-Alzheimer Disease', 'Urinary Bladder Diseases-complicate-Urinary Incontinence, Stress', 'Dementia-distinguish-Delirium', 'Prostatic Hyperplasia-found-Prostatic Neoplasms', 'Multiple Organ Failure-promote-Neoplasms', 'Back Pain-query-Osteoporosis', 'Myalgia-query-Osteoporosis', 'Vaccinia-induced-Infections', 'Scabies-reported-Immunologic Deficiency Syndromes', 'Exanthema-receive-Pain', 'Intellectual Disability-substantiate-Diabetes Mellitus', 'Cardiomyopathies-associated-Mitochondrial Diseases', 'Mitochondrial Diseases-associated-Cardiomyopathies', 'Heart Failure-represent-Heart Diseases', 'Aspartylglucosaminuria-display-Sleep Wake Disorders', 'Heart Failure-focus-Alzheimer Disease', 'Microsporidiosis-include-HIV Infections', 'Amnesia-receive-Dementia', 'Amnesia-progress-Dementia, Vascular', 'Amnesia-progress-Dementia', 'Status Epilepticus-accompany-Nerve Degeneration', 'Asthma-develop-Brain Diseases', 'Asthma-develop-Status Epilepticus', 'Cardiac Output, Low-fall-Urinary Bladder Diseases', 'Fasciitis, Necrotizing-underlie-Rectal Neoplasms', 'Cataract-lead-Fibrosis', 'Fibrosis-lead-Vision Disorders', 'Neurologic Manifestations-develop-Alzheimer Disease', 'Parkinson Disease-include-Communicable Diseases', 'Aortitis-include-IgA Vasculitis', 'Aortitis-develop-Aortic Aneurysm', 'Giant Cell Arteritis-develop-Aneurysm', 'Death-relate-Malaria', 'Osteoarthritis, Spine-assess-Fractures, Bone', 'Inflammation-induced-Ischemia', 'Parkinson Disease-recorded-Death', 'Fractures, Bone-consist-Osteoporosis', 'Fractures, Bone-consist-Cardiac Output, Low', 'Cardiovascular Diseases-affect-Atrial Fibrillation', 'Huntington Disease-include-Alzheimer Disease', 'Alzheimer Disease-fueled-Neurologic Manifestations', 'Tauopathies-fueled-Neurologic Manifestations', 'Cerebrovascular Disorders-reveal-Alzheimer Disease', 'Aneurysm-reveal-Alzheimer Disease', 'Stroke-find-Sleep Initiation and Maintenance Disorders', 'Stroke-find-Delirium', 'Metabolic Diseases-find-Sleep Initiation and Maintenance Disorders', 'Metabolic Diseases-find-Delirium', 'Dementia-find-Sleep Initiation and Maintenance Disorders', 'Dementia-find-Delirium', 'Coma-find-Sleep Initiation and Maintenance Disorders', 'Coma-find-Delirium', 'Brain Infarction-develop-Delirium', 'Delirium-include-Cerebral Hemorrhage', 'Delirium-include-Sleep Initiation and Maintenance Disorders', 'Temporomandibular Joint Disorders-assess-Joint Diseases', 'Porphyria, Acute Intermittent-result-Drug-Related Side Effects and Adverse Reactions', 'Infections-induce-Phenylketonurias', 'Aphasia-administered-Dementia, Vascular', 'Plaque, Atherosclerotic-reduce-Hemostatic Disorders', 'Plaque, Atherosclerotic-arise-Gastrointestinal Hemorrhage', 'Alzheimer Disease-classify-Atrophy', 'Atrophy-raise-Alzheimer Disease', 'Alzheimer Disease-develop-Aneurysm', 'Diabetes Mellitus-used-Dementia', 'Precursor Cell Lymphoblastic Leukemia-Lymphoma-associated-Leukemia', 'Leukemia-associated-Precursor Cell Lymphoblastic Leukemia-Lymphoma', 'Delayed Emergence from Anesthesia-improve-Death', 'Anemia-accompany-Heart Failure', 'Anemia-termed-Cardio-Renal Syndrome', 'Renal Insufficiency, Chronic-accompany-Heart Failure', 'Renal Insufficiency, Chronic-exacerbate-Cardio-Renal Syndrome', 'Heart Failure-termed-Cardio-Renal Syndrome', 'Anemia-considered-Heart Failure', 'Anemia-treated-Hyperthyroidism', 'Anemia-treated-Hypothyroidism', 'Anemia-treated-Sleep Apnea, Obstructive', 'Restless Legs Syndrome-arose-Parkinson Disease', 'Pain-experienced-Dementia', 'Pain-treat-Dementia', 'Pain-perceive-Death', 'Chronic Disease-related-Leprosy', 'Drug-Related Side Effects and Adverse Reactions-resemble-Neurodegenerative Diseases', 'Neurotoxicity Syndromes-resemble-Neurodegenerative Diseases', 'Microvascular Angina-play-Dementia', 'Aneurysm-treated-Genetic Diseases, Inborn', 'Neoplasms-appear-Coinfection', 'Neoplasms-appear-Hepatitis B', 'Stroke-remain-Myocardial Infarction', 'Carotid Artery Diseases-implicated-Stroke', 'Sleep Apnea, Obstructive-define-Stroke', 'Muscular Diseases-range-Fatigue', 'Muscular Diseases-range-Muscle Weakness', 'Muscular Diseases-range-Pain', 'Fatigue-range-Rhabdomyolysis', 'Muscle Weakness-range-Rhabdomyolysis', 'Pain-range-Rhabdomyolysis', 'Glioblastoma-prevent-Neoplasms', 'Immunologic Deficiency Syndromes-engrafted-Pneumococcal Infections', 'Refractive Errors-create-Amblyopia', 'Urinary Incontinence-increase-Spinal Cord Injuries', 'Neuralgia-increase-Spinal Cord Injuries', 'Neoplasms-represent-Cardiovascular Diseases', 'Liver Neoplasms-include-Nervous System Diseases', 'Obesity-experience-Genetic Diseases, Inborn', 'Chronic Disease-experience-Genetic Diseases, Inborn', 'Corneal Opacity-account-Blindness', 'Atrial Fibrillation-emanates-Hyperpigmentation', 'Diabetes Mellitus-account-Aneurysm', 'Hyperhomocysteinemia-associated-Neurodegenerative Diseases', 'Neurodegenerative Diseases-associated-Hyperhomocysteinemia', 'Diabetes Mellitus-increase-Myocardial Infarction', 'Diabetes Mellitus-establish-Kidney Diseases', 'Albuminuria-improve-Glycosuria', 'Diabetic Nephropathies-become-Diabetes Mellitus', 'Diabetic Nephropathies-think-Diabetes Mellitus', 'Hepatolenticular Degeneration-appear-Kidney Diseases', 'Diabetic Nephropathies-become-Kidney Diseases', 'Hepatolenticular Degeneration-appear-Diabetes Mellitus', 'Kidney Diseases-become-Diabetes Mellitus', 'Kidney Diseases-think-Diabetes Mellitus', 'Diabetes Mellitus-enter-Renal Insufficiency', 'Diabetes Mellitus-develop-Renal Insufficiency', 'Diabetes Mellitus-survive-Aneurysm', 'Renal Insufficiency-survive-Aneurysm', 'Cough-unaffected-Asthma', 'Cough-unaffected-Pulmonary Disease, Chronic Obstructive', 'Mitochondrial Diseases-found-Alzheimer Disease', 'Alzheimer Disease-search-Parkinson Disease', 'Alzheimer Disease-found-Nerve Degeneration', 'Lung Neoplasms-comprise-Adenocarcinoma', 'Ulcer-associated-Skin Diseases', 'Skin Diseases-associated-Ulcer', 'Ulcer-associated-Fecal Incontinence', 'Fecal Incontinence-associated-Ulcer', 'Musculoskeletal Diseases-relieve-Pain', 'Dementia-report-Craniocerebral Trauma', 'Inflammation-dissect-Neurodegenerative Diseases', 'Pain-range-Dyspepsia', 'Inflammation-range-Dyspepsia', 'Alzheimer Disease-included-Dementia', 'Death-need-Chronic Disease', 'Death-need-Acute Kidney Injury', 'Death-precipitated-Heart Failure', 'Death-need-Infections', 'Death-need-Oliguria', 'Chronic Disease-precipitated-Heart Failure', 'Acute Kidney Injury-precipitated-Heart Failure', 'Chronic Disease-associated-Sepsis', 'Sepsis-associated-Chronic Disease', 'Acute Kidney Injury-precipitated-Infections', 'Chronic Disease-associated-Oliguria', 'Oliguria-associated-Chronic Disease', 'Acute Kidney Injury-need-Oliguria', 'Hypertension-impair-Glucose Intolerance', 'Glucose Intolerance-accelerate-Diabetes Mellitus', 'Headache-trigger-Neck Pain', 'Headache-reflect-Migraine Disorders', 'Cardiac Output, Low-predict-Pain', 'Neoplasms-include-Aneurysm', 'Infections-include-Aneurysm', 'Leukemia-present-Infections', 'Werner Syndrome-associated-Diabetes Mellitus, Type 2', 'Diabetes Mellitus, Type 2-associated-Werner Syndrome', 'Inflammation-block-Werner Syndrome', 'Werner Syndrome-involved-Inflammation', 'Prostatic Hyperplasia-stem-Erectile Dysfunction', 'Pain-treat-Osteoporotic Fractures', 'Inflammation-represent-Infections', 'Inflammation-surpass-Neoplasms', 'Arthritis, Rheumatoid-represent-Osteoarthritis', 'Arthritis, Rheumatoid-represent-Osteoporosis', 'Medulloblastoma-recognized-Brain Neoplasms', 'Respiratory Tract Infections-associated-Bronchiolitis', 'Bronchiolitis-associated-Respiratory Tract Infections', 'Hypertension-extend-Stroke', 'Stroke-extend-Heart Failure', 'Wounds and Injuries-decrease-Pulmonary Embolism', 'Venous Thromboembolism-manifested-Venous Thrombosis', 'Venous Thromboembolism-manifested-Pulmonary Embolism', 'Venous Thrombosis-manifested-Death', 'Mitral Valve Insufficiency-considered-Heart Failure', 'Death-exclude-Respiratory Tract Diseases', 'Death-exclude-Stroke', 'Death-exclude-Coronary Artery Disease', 'Respiratory Tract Diseases-exclude-Death', 'Stroke-exclude-Death', 'Coronary Artery Disease-exclude-Death', 'Memory Disorders-evaluate-Alzheimer Disease', 'Lung Injury-repair-Emphysema', 'Neoplasms-based-Death', 'Cardiovascular Abnormalities-play-Neoplasms', 'Hypertension-consider-Stroke', 'Hypertension-avoid-Stroke', 'Fractures, Bone-played-Osteoporosis', 'Vascular Calcification-predispose-Death', 'Stroke-experience-Heart Failure', 'Diabetes Mellitus-experience-Heart Failure', 'Heart Failure-imparted-Stroke', 'Death-imparted-Stroke', 'Pancreatic Neoplasms-inactivated-Neoplasms', 'Polymyalgia Rheumatica-predominate-Musculoskeletal Diseases', 'Polymyalgia Rheumatica-predominate-Giant Cell Arteritis', 'Polymyalgia Rheumatica-predominate-Inflammation', 'Polymyalgia Rheumatica-predominate-Death', 'Musculoskeletal Diseases-predominate-Inflammation', 'Musculoskeletal Diseases-predominate-Death', 'Restless Legs Syndrome-experience-Sleep Wake Disorders', 'Nocturnal Myoclonus Syndrome-experience-Sleep Wake Disorders', 'Death-exerted-Communicable Diseases', 'Brain Infarction-known-Stroke', 'Brain Infarction-represent-Cerebral Infarction', 'Stroke-known-Cerebral Infarction', 'Colorectal Neoplasms-improve-Stomatitis', 'Diarrhea-show-Dysentery, Bacillary', 'Malaria-originate-Death', 'Gout-include-Obesity', 'Gout-identify-Hyperuricemia', 'Gout-considered-Breast Neoplasms, Male', 'Fat Necrosis-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-Fat Necrosis', 'Atherosclerosis-associated-Osteoporosis', 'Osteoporosis-associated-Atherosclerosis', 'Prostatic Hyperplasia-develop-Urinary Retention', 'Friedreich Ataxia-cause-Ophthalmoplegia', 'Friedreich Ataxia-cause-Parkinson Disease, Secondary', 'Parkinson Disease-cause-Ophthalmoplegia', 'Parkinson Disease-cause-Parkinson Disease, Secondary', 'Immunologic Deficiency Syndromes-give-Restless Legs Syndrome', 'Myocardial Infarction-enter-Diabetes Mellitus', 'Stroke-enter-Diabetes Mellitus', 'Cardiovascular Diseases-use-Diabetes Mellitus', 'Death-enter-Diabetes Mellitus', 'Tuberculosis-contribute-Infections', 'Dementia-lower-Alzheimer Disease', 'Malnutrition-associated-Lung Diseases', 'Lung Diseases-associated-Malnutrition', 'Arrhythmias, Cardiac-prevent-Ventricular Premature Complexes', 'Death-corrected-Aortic Valve Insufficiency', 'Shock-exposed-Hearing Disorders', 'Prostatic Neoplasms-excluded-Prostatic Hyperplasia', 'Melanoma-include-Skin Neoplasms', 'Melanoma-associated-Xeroderma Pigmentosum', 'Xeroderma Pigmentosum-associated-Melanoma', 'Pain-work-Dementia', 'Pulmonary Disease, Chronic Obstructive-predict-Death', 'Peripheral Vascular Diseases-predict-Death', 'Diabetic Angiopathies-include-Hypertension', 'Diabetic Angiopathies-include-Inflammation', 'Hematologic Neoplasms-grouped-Myelodysplastic Syndromes', 'Osteolysis-become-Fatigue', 'Osteolysis-become-Infections', 'Fatigue-become-Infections', 'Scoliosis-predispose-Osteoporosis', 'Osteoporosis-predispose-Scoliosis', 'Severe Acute Respiratory Syndrome-associated-Voice Disorders', 'Voice Disorders-associated-Severe Acute Respiratory Syndrome', 'Reperfusion Injury-lead-Stroke', 'Leukemia, Myelogenous, Chronic, BCR-ABL Positive-expressed-Cholestasis', 'Xerostomia-follow-Hemorrhage', 'Xerostomia-follow-Stomatitis', 'Infections-recognized-Carcinogenesis', 'Inflammation-recognized-Carcinogenesis', 'Hyperglycemia-observed-Obesity', 'Obesity-noted-Hyperinsulinism', 'Infections-suffer-Pain', 'Leukemia-yield-Drug-Related Side Effects and Adverse Reactions', 'Stroke-occur-Heart Diseases', 'Huntington Disease-protect-Drug-Related Side Effects and Adverse Reactions', 'Stroke-occur-Communicable Diseases', 'Neoplasms-achieve-Pain', 'Respiratory Insufficiency-treat-Pain', 'Pain-treat-Neoplasms', 'Pancreatitis-show-Diabetes Mellitus', 'Pancreatitis-show-Alcoholism', 'Diabetes Mellitus-increase-Alcoholism', 'Pancreatitis-described-Pancreatic Diseases', 'Pancreatitis-described-Biliary Tract Diseases', 'Sleep Wake Disorders-related-Neurologic Manifestations', 'Sleep Wake Disorders-related-Restless Legs Syndrome', 'Sleep Initiation and Maintenance Disorders-defined-Nocturnal Myoclonus Syndrome', 'Disorders of Excessive Somnolence-defined-Nocturnal Myoclonus Syndrome', 'Hyperthyroidism-arise-Thyroid Diseases', 'Kidney Diseases-lead-Hypertrophy', 'Headache Disorders, Secondary-concentrate-Memory Disorders', 'Muscle Weakness-concentrate-Memory Disorders', 'Fatigue-concentrate-Memory Disorders', 'Sleep Initiation and Maintenance Disorders-concentrate-Memory Disorders', 'Anemia-present-Paraplegia', 'Osteoporosis-associated-Weight Loss', 'Weight Loss-associated-Osteoporosis', 'Infections-transplant-Immunologic Deficiency Syndromes', 'Neoplasms-rising-Death', 'Neoplasms-rising-Multiple Myeloma', 'Erectile Dysfunction-provide-Metabolic Syndrome', 'Erectile Dysfunction-provide-Cardiovascular Diseases', 'Muscular Dystrophy, Duchenne-seen-Fractures, Bone', 'Pain-affect-Dementia', 'Chronic Disease-include-Pulmonary Disease, Chronic Obstructive', 'Chronic Disease-include-Coronary Artery Disease', 'Chronic Disease-include-Hyperlipidemias', 'Chronic Disease-include-Osteoarthritis', 'Chronic Disease-include-Arthritis', 'Chronic Disease-include-Neck Pain', 'Rheumatic Diseases-achieve-Pain', 'Death-reveal-Heart Failure', 'Death-reveal-Shock, Cardiogenic', 'Stroke-treated-Hypertension', 'Chronic Disease-related-Muscle Weakness', 'Chronic Disease-decline-AIDS Dementia Complex', 'Muscle Weakness-decline-AIDS Dementia Complex', 'Hypoxia-implicated-Neurodegenerative Diseases', 'Neoplasms-include-Cerebrovascular Disorders', 'Wounds and Injuries-include-Cerebrovascular Disorders', 'Fractures, Bone-include-Cerebrovascular Disorders', 'Cerebrovascular Disorders-include-Mononeuropathies', 'Cerebrovascular Disorders-isolate-Mononeuropathies', 'Neoplasms-isolate-Mononeuropathies', 'Wounds and Injuries-isolate-Mononeuropathies', 'Fractures, Bone-isolate-Mononeuropathies', 'Parkinsonian Disorders-provoke-Olfaction Disorders', 'Optic Nerve Diseases-thought-Ocular Hypertension', 'Death-mediated-Atherosclerosis', 'Death-confined-Coronary Artery Disease', 'Atherosclerosis-confined-Coronary Artery Disease', 'Olfaction Disorders-start-Supranuclear Palsy, Progressive', 'Pain-assess-Memory Disorders', 'Dementia-assess-Memory Disorders', 'Ischemia-related-Stroke', 'Chest Pain-related-Stroke', 'Tremor-achieved-Neoplasms', 'Vascular Calcification-predict-Hemolytic-Uremic Syndrome', 'Atherosclerosis-predict-Hemolytic-Uremic Syndrome', 'Hypertension-associated-Werner Syndrome', 'Werner Syndrome-associated-Hypertension', 'Adenoma-progress-Colorectal Neoplasms', 'Anemia-remain-Death', 'Metabolic Syndrome-measure-Stroke', 'Metabolic Syndrome-measure-Coronary Artery Disease', 'Metabolic Syndrome-measure-Diabetes Mellitus', 'Metabolic Syndrome-compare-Cardiovascular Diseases', 'Metabolic Syndrome-compare-Death', 'Blindness-account-Diabetes Mellitus', 'Renal Insufficiency-account-Diabetes Mellitus', 'Nervous System Diseases-account-Diabetes Mellitus', 'Stroke-receive-Lipid Metabolism Disorders', 'Coronary Artery Disease-receive-Lipid Metabolism Disorders', 'Parkinson Disease-experience-Constipation', 'Parkinson Disease-report-Constipation', 'Frailty-identified-Muscle Weakness', 'Frailty-identified-Weight Loss', 'Alveolitis, Extrinsic Allergic-represent-Lung Diseases', 'Diabetes Mellitus-reduce-Stroke', 'Alveolitis, Extrinsic Allergic-promote-Chronic Disease', 'Alveolitis, Extrinsic Allergic-progress-Fibrosis', 'Alveolitis, Extrinsic Allergic-provoke-Emphysematous Cholecystitis', 'Bronchiolitis-exist-Pneumonia', 'Pulmonary Fibrosis-exist-Pneumonia', 'Granuloma-exist-Pneumonia', 'Delirium-studied-Death', 'Pulmonary Embolism-rule-Neoplasms', 'Neoplasms-affect-Sialadenitis', "Neoplasms-affect-Sjogren's Syndrome", 'Neoplasms-affect-Xerostomia', 'Hypogonadism-select-Erectile Dysfunction', 'Sleep Initiation and Maintenance Disorders-predict-Substance-Related Disorders', 'Sleep Initiation and Maintenance Disorders-develop-Substance-Related Disorders', 'Fractures, Bone-predisposed-Osteoporosis', 'Neoplasms-begin-Death', 'Fecal Incontinence-represent-Disease', 'Dementia-underlie-Delirium', 'Cardiovascular Diseases-develop-Pain', 'Esophageal Achalasia-undergo-Neoplasms', 'Esophageal Achalasia-undergo-Barrett Esophagus', 'Esophageal Achalasia-undergo-Varicose Ulcer', 'Esophageal Achalasia-undergo-Sepsis', 'Esophageal Achalasia-undergo-Deglutition Disorders', 'Hemostatic Disorders-limited-Wounds and Injuries', 'Heart Failure-confer-Coronary Artery Disease', 'Sarcopenia-coupled-Fatigue', 'Death-function-Diabetes Mellitus', 'Heart Failure-thrive-Growth Disorders', 'Sarcopenia-control-Death', 'Fractures, Open-expect-Death', 'Neoplasms-play-Blood Coagulation Disorders', 'Polyneuropathies-seem-Nervous System Diseases', 'Polyneuropathies-followed-Diabetes Mellitus', 'Nervous System Diseases-followed-Diabetes Mellitus', 'Chronic Disease-analyzed-Death', 'Delirium-assessed-Dementia', 'Parkinson Disease-select-Movement Disorders', 'Wounds and Injuries-associated-Spondylosis', 'Spondylosis-associated-Wounds and Injuries', 'Wounds and Injuries-associated-Central Cord Syndrome', 'Central Cord Syndrome-associated-Wounds and Injuries', 'Wounds and Injuries-cause-Central Cord Syndrome', 'Spondylosis-cause-Central Cord Syndrome', 'Calcinosis-associated-Heart Failure', 'Heart Failure-associated-Calcinosis', 'Thromboembolism-occur-Venous Insufficiency', 'Death-expect-Neoplasms', 'Thromboembolism-occur-Neoplastic Cells, Circulating', 'Death-expect-Myocardial Infarction', 'Thromboembolism-occur-Venous Thrombosis', 'Death-expect-Stroke', 'Thromboembolism-occur-Pulmonary Embolism', 'Hip Fractures-provide-Hypotension', 'Periodontitis-compare-Malnutrition', 'Malnutrition-associated-Atherosclerosis', 'Atherosclerosis-associated-Malnutrition', 'Diabetes Mellitus-associated-Periodontitis', 'Periodontitis-associated-Diabetes Mellitus', 'Heart Valve Diseases-connected-Ventricular Septal Rupture', 'Heat Stroke-result-Delirium', 'Heat Stroke-result-Seizures', 'Heat Stroke-result-Coma', 'Malignant Hyperthermia-cause-Drug-Related Side Effects and Adverse Reactions', 'Heat Stroke-resemble-Sepsis', 'Heat Stroke-implicated-Endotoxemia', 'Sepsis-implicated-Endotoxemia', 'Dehydration-favor-Heat Stroke', 'Sleep Initiation and Maintenance Disorders-favor-Heat Stroke', 'Seizures-favor-Heat Stroke', 'Stroke-exist-Hypoxia, Brain', 'Hyponatremia-considered-Delirium', 'Diabetes Mellitus-related-Infections', 'Hypertension-impact-Alzheimer Disease', 'Dementia, Vascular-impact-Alzheimer Disease', 'Cardiovascular Diseases-divided-Hypertension', 'Osteoporotic Fractures-implicated-Hyperparathyroidism', 'Inflammation-occur-Inflammatory Bowel Diseases', 'Retinal Degeneration-range-Gastrointestinal Diseases', 'Inflammation-develop-Inflammatory Bowel Diseases', 'Inflammation-develop-Nervous System Diseases', 'Osteoporosis-derive-Fractures, Bone', 'Diabetes Mellitus-include-Neoplasms', 'Death-increased-Heart Diseases', 'Urinary Bladder Diseases-lead-Urinary Incontinence', 'Heart Failure-contribute-Fibrosis', 'Heart Failure-contribute-Coronary Artery Disease', 'Heart Failure-contribute-Aortic Diseases', 'Neoplasms-offer-Death', 'Death-exhibit-Infections', 'Prostatic Hyperplasia-directed-Prostatitis', 'Amyloidosis-appear-Atrial Fibrillation', 'Dystonia-affect-Nerve Degeneration', 'Obesity-play-Prostatic Hyperplasia', 'Infections-result-Neoplasms', 'Diabetes Mellitus-develop-Acute Kidney Injury', 'Heart Failure-develop-Acute Kidney Injury', 'Acute Kidney Injury-develop-Respiratory Insufficiency', 'Acute Kidney Injury-develop-Death', 'Hypotension-caused-Cross Infection', 'Hypotension-caused-Gastrointestinal Hemorrhage', 'Hypotension-caused-Severe Acute Respiratory Syndrome', 'Cross Infection-caused-Rhabdomyolysis', 'Cross Infection-associated-Acute Kidney Injury', 'Acute Kidney Injury-associated-Cross Infection', 'Gastrointestinal Hemorrhage-caused-Rhabdomyolysis', 'Gastrointestinal Hemorrhage-associated-Acute Kidney Injury', 'Acute Kidney Injury-associated-Gastrointestinal Hemorrhage', 'Acute Kidney Injury-associated-Rhabdomyolysis', 'Rhabdomyolysis-associated-Acute Kidney Injury', 'Severe Acute Respiratory Syndrome-caused-Rhabdomyolysis', 'Severe Acute Respiratory Syndrome-associated-Acute Kidney Injury', 'Acute Kidney Injury-associated-Severe Acute Respiratory Syndrome', 'Severe Acute Respiratory Syndrome-associated-Hypotension', 'Hypotension-associated-Severe Acute Respiratory Syndrome', 'Severe Acute Respiratory Syndrome-associated-Rhabdomyolysis', 'Rhabdomyolysis-associated-Severe Acute Respiratory Syndrome', 'Severe Acute Respiratory Syndrome-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-Severe Acute Respiratory Syndrome', 'Osteoporosis-control-Coronary Artery Disease', 'Hyperphosphatemia-enhance-Death', 'Hyperphosphatemia-play-Cardiovascular Diseases', 'Dementia, Vascular-recovered-Alzheimer Disease', 'Dementia, Vascular-accumulate-Cerebrovascular Disorders', 'Dementia, Vascular-acquire-Alzheimer Disease', 'Cerebrovascular Disorders-acquire-Alzheimer Disease', 'Dementia, Vascular-exhibit-Alzheimer Disease', 'Cerebrovascular Trauma-treat-Atherosclerosis', 'Breast Neoplasms-reveal-Neoplasms', 'Hyperkinesis-receive-Delirium', 'Crystal Arthropathies-include-Arthralgia', 'Gout-include-Arthralgia', 'Osteoarthritis-include-Arthralgia', 'Arthritis, Infectious-include-Arthralgia', 'Back Pain-associated-Fatigue', 'Fatigue-associated-Back Pain', 'Back Pain-associated-Arthralgia', 'Arthralgia-associated-Back Pain', 'Wounds and Injuries-associate-Spinal Fractures', 'Spinal Fractures-associate-Wounds and Injuries', 'Neurologic Manifestations-associate-Spinal Fractures', 'Spinal Fractures-associate-Neurologic Manifestations', 'Heart Diseases-associated-Inflammation', 'Inflammation-associated-Heart Diseases', 'Lung Diseases-associated-Inflammation', 'Inflammation-associated-Lung Diseases', 'Pain-treat-Fractures, Bone', 'Pain-consider-Venous Thrombosis', 'Heart Arrest-group-Death', 'Edema-consider-Venous Thrombosis', 'Muscle Cramp-consider-Venous Thrombosis', 'Pneumonia-reported-Alcoholism', 'Pneumonia-reported-Heart Diseases', 'Sarcopenia-used-Osteoporosis', 'Diabetes Mellitus-rank-Cataract', 'Growth Hormone-Secreting Pituitary Adenoma-cause-Bone Diseases, Metabolic', 'Growth Hormone-Secreting Pituitary Adenoma-protect-Fractures, Bone', 'Bone Diseases, Metabolic-protect-Fractures, Bone', 'Neoplasms-caused-Inflammation', 'Alcoholism-aggravate-Voice Disorders', 'Drug Hypersensitivity-aggravate-Voice Disorders', 'Acute Kidney Injury-correlated-Renal Insufficiency, Chronic', 'Infections-reduce-Bacteremia', 'Bacteremia-result-Death', 'Cardiovascular Diseases-classified-Stroke', 'Cardiovascular Diseases-classified-Death', 'Cardiovascular Diseases-reported-Death', 'Stroke-reported-Death', 'Neoplasms-identify-Obesity', 'Neoplasms-identify-Heart Arrest', 'Euthyroid Sick Syndromes-restore-Hypothyroidism', 'Inflammation-regarded-Hypercholesterolemia', 'Inflammation-coalesce-Hypercholesterolemia', 'Inflammation-regarded-Hypothyroidism', 'Inflammation-coalesce-Hypothyroidism', 'Inflammation-regarded-Ischemia', 'Inflammation-enhance-Ischemia', 'Hypothyroidism-coalesce-Hypercholesterolemia', 'Hematoma-caused-Wounds and Injuries', 'Stroke-result-Hypertension', 'Cough-followed-Chest Pain', 'Cough-followed-Hemoptysis', 'Brain Diseases-develop-Hepatitis E', 'Chemical and Drug Induced Liver Injury-defined-Hepatic Encephalopathy', 'Parkinson Disease, Secondary-associated-Weight Loss', 'Weight Loss-associated-Parkinson Disease, Secondary', 'Parkinson Disease-lose-Weight Loss', 'Hallucinations-associated-Weight Loss', 'Weight Loss-associated-Hallucinations', 'Neurodegenerative Diseases-associated-Weight Loss', 'Weight Loss-associated-Neurodegenerative Diseases', 'Dementia-influence-Stroke', 'Epilepsy, Generalized-characterized-Fractures, Bone', 'Lung Diseases, Obstructive-discount-Death', 'Heart Failure, Systolic-seen-Bundle-Branch Block', 'Heart Failure-experience-Death', 'Pneumothorax-lead-Hematoma', 'Hematoma-lead-Infections', 'Peripheral Nervous System Diseases-develop-Pain', 'Nervous System Diseases-involve-Neuralgia', 'Carcinoma, Ductal-remain-Breast Neoplasms', 'Carcinoid Heart Disease-remain-Death', 'Carcinoid Heart Disease-remain-Malignant Carcinoid Syndrome', 'Metabolic Diseases-characterized-Cardiovascular Diseases', 'Respiratory Tract Diseases-contribute-Death', 'Nervous System Diseases-contribute-Death', 'Dyskinesia, Drug-Induced-characterized-Tremor', 'Aneurysm-affect-Renal Insufficiency', 'Renal Insufficiency-affect-Kidney Diseases', 'Renal Insufficiency-associated-Coronary Artery Disease', 'Coronary Artery Disease-associated-Renal Insufficiency', 'Renal Insufficiency-associated-Hypertension', 'Hypertension-associated-Renal Insufficiency', 'Renal Insufficiency-associated-Cerebrovascular Disorders', 'Cerebrovascular Disorders-associated-Renal Insufficiency', 'Hypertension-correlate-Aneurysm', 'Proteinuria-correlate-Aneurysm', 'Renal Insufficiency-correlate-Aneurysm', 'Diabetes Mellitus-correlate-Aneurysm', 'Kidney Diseases-signify-Aneurysm', 'Pneumothorax-reveal-Focal Nodular Hyperplasia', 'Hemangiosarcoma-present-Pneumothorax', 'Pneumothorax-differentiated-Lung Neoplasms', 'Diabetes Mellitus, Type 2-develop-Atherosclerosis', 'Diabetes Mellitus, Type 2-develop-Ischemia', 'Chronic Disease-related-Pain', 'Breast Neoplasms-related-Pain', 'Diabetes Mellitus-used-Musculoskeletal Diseases', 'Diabetes Mellitus-used-Ischemia', 'Diabetes Mellitus-detect-Nervous System Diseases', 'Gastroesophageal Reflux-treat-Hernia, Hiatal', 'Gastroesophageal Reflux-treat-Death', 'Ulcer-minimized-Pain', 'Femoral Neck Fractures-related-Fractures, Bone', 'Infections-eradicated-Esophageal Neoplasms', 'Carcinoma, Hepatocellular-include-Chronic Disease', 'Blind Loop Syndrome-exclude-Intestinal Diseases', 'Blind Loop Syndrome-exclude-Respiratory Tract Infections', 'Diabetes Mellitus-arise-Heart Diseases', 'Pain-relieve-Peripheral Nervous System Diseases', 'Pain-improve-Neuralgia', 'Hemoptysis-present-Neoplasms', 'Vascular Calcification-encountered-Atherosclerosis', 'Calcinosis-considered-Atherosclerosis', 'Calcinosis-considered-Inflammation', 'Renal Insufficiency, Chronic-develop-Hyperphosphatemia', 'Renal Insufficiency, Chronic-find-Hypertension', 'Renal Insufficiency, Chronic-find-Hyperlipidemias', 'Renal Insufficiency, Chronic-find-Diabetes Mellitus', 'Renal Insufficiency, Chronic-find-Vascular Calcification', 'Fever-presented-Chemical and Drug Induced Liver Injury', 'Fever-presented-Pneumonia', 'Pneumonia-constitute-Death', 'Pneumonia-constitute-Infections', 'Diverticulum-suffer-Diverticulitis', 'Diverticulum-suffer-Hemorrhage', 'Irritable Bowel Syndrome-suffer-Diverticulitis', 'Irritable Bowel Syndrome-suffer-Hemorrhage', 'Diverticulitis-suffer-Hemorrhage', 'Opium Dependence-develop-Alzheimer Disease', 'Progeria-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-Progeria', 'Progeria-suffer-Myocardial Infarction', 'Progeria-suffer-Stroke', 'Progeria-suffer-Cardiovascular Diseases', 'Cardiovascular Diseases-lead-Stroke', 'Ulcer-present-Enteropathy-Associated T-Cell Lymphoma', 'Alzheimer Disease-recognize-Chronic Disease', 'Hypertension-present-Diabetes Mellitus', 'Headache Disorders-remain-Migraine Disorders', 'Peripheral Arterial Disease-associated-Intermittent Claudication', 'Intermittent Claudication-associated-Peripheral Arterial Disease', 'Peripheral Arterial Disease-associated-Limb Deformities, Congenital', 'Limb Deformities, Congenital-associated-Peripheral Arterial Disease', 'Coronary Artery Disease-coexist-Peripheral Arterial Disease', 'Atherosclerosis-coexist-Peripheral Arterial Disease', 'Metabolic Syndrome-base-Obesity, Abdominal', 'Hypertension-depend-Stroke', 'Periodontitis-associated-Calculi', 'Calculi-associated-Periodontitis', 'Periodontitis-associated-Obesity', 'Obesity-associated-Periodontitis', 'Myalgia-characterized-Muscle Weakness', 'Myalgia-characterized-Death', 'Alzheimer Disease-increase-Atrophy', 'Somatosensory Disorders-combined-Muscle Weakness', 'Genetic Diseases, Inborn-consist-Vertigo', 'Pain-result-Musculoskeletal Diseases', 'Fractures, Bone-result-Musculoskeletal Diseases', 'Osteomalacia-cause-Adrenal Insufficiency', 'Polymyalgia Rheumatica-affected-Diabetes Mellitus', 'Polymyalgia Rheumatica-affected-Osteoporosis', 'Gastrointestinal Hemorrhage-include-Hemorrhage', 'Dementia-related-Cerebrovascular Disorders', 'Neoplasms-registered-Breast Neoplasms', 'Neoplasms-registered-Carcinoma, Non-Small-Cell Lung', 'Ventricular Septal Rupture-account-Abnormalities, Drug-Induced', 'Drug-Related Side Effects and Adverse Reactions-target-Infections', 'Anemia-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-Anemia', 'Anemia-result-Inflammation', 'Anemia-result-Renal Insufficiency, Chronic', 'Renal Tubular Transport, Inborn Errors-induced-Diabetes Mellitus', 'Alzheimer Disease-associated-Genetic Diseases, Inborn', 'Genetic Diseases, Inborn-associated-Alzheimer Disease', 'Alzheimer Disease-alter-Mastocytosis, Systemic', 'Alzheimer Disease-alter-Drug-Related Side Effects and Adverse Reactions', 'Alzheimer Disease-alter-Mitochondrial Diseases', 'Alzheimer Disease-alter-Neurodegenerative Diseases', 'Mastocytosis, Systemic-lead-Death', 'Erectile Dysfunction-treat-Urinary Bladder, Overactive', 'Prostatic Hyperplasia-treat-Urinary Incontinence', 'Argyria-accepted-Skin Diseases', 'Rare Diseases-characterized-Death', 'Rare Diseases-characterized-Atherosclerosis', 'Opportunistic Infections-account-Death', 'Hyponatremia-occur-Hypovolemia', 'Infections-lead-Diarrhea', 'Vision Disorders-lead-Glaucoma', 'Nocturia-increased-Hip Fractures', 'Atherosclerosis-coincide-Fibrosis', 'Kidney Diseases-intended-Renal Insufficiency, Chronic', 'Arthritis-remain-Peptic Ulcer', 'Rheumatic Diseases-remain-Peptic Ulcer', 'Optic Neuritis-cause-Vision Disorders', 'Tuberculosis-associated-Eye Diseases', 'Eye Diseases-associated-Tuberculosis', 'Optic Neuritis-cause-Scotoma', 'Neuritis-cause-Vision Disorders', 'Neuritis-cause-Scotoma', 'Optic Neuritis-considered-Drug-Related Side Effects and Adverse Reactions', 'Osteoporotic Fractures-evaluated-Osteoporosis', 'Arteriosclerosis-caused-Obesity, Metabolically Benign', 'Lymphoma-reduce-Infections', 'Leukopenia-occur-Infections', 'Fractures, Bone-avoid-Heart Failure', 'Insomnia, Fatal Familial-increase-Death', 'Death-noted-Chronic Disease', 'Neoplasms-ameliorate-Metabolic Syndrome', 'Diabetes Mellitus-ameliorate-Metabolic Syndrome', 'Lymphohistiocytosis, Hemophagocytic-account-Pancytopenia', 'Lymphohistiocytosis, Hemophagocytic-account-Chemical and Drug Induced Liver Injury', 'Lymphohistiocytosis, Hemophagocytic-account-Multiple Organ Failure', 'Neoplasms-occur-Cachexia', 'Hereditary Breast and Ovarian Cancer Syndrome-associated-Metabolic Diseases', 'Metabolic Diseases-associated-Hereditary Breast and Ovarian Cancer Syndrome', 'Hereditary Breast and Ovarian Cancer Syndrome-associated-Muscle Weakness', 'Muscle Weakness-associated-Hereditary Breast and Ovarian Cancer Syndrome', 'Hereditary Breast and Ovarian Cancer Syndrome-associated-Edema', 'Edema-associated-Hereditary Breast and Ovarian Cancer Syndrome', 'Hereditary Breast and Ovarian Cancer Syndrome-associated-Fatigue', 'Fatigue-associated-Hereditary Breast and Ovarian Cancer Syndrome', 'Infections-suffering-Candidiasis, Oral', 'Death-tend-Nephrotic Syndrome', 'Death-tend-Shock', 'Stomatitis-found-Xerostomia', 'Cataract-help-Corneal Diseases', 'Thromboembolism-prevent-Postoperative Hemorrhage', 'Tinnitus-exhibited-Hearing Loss', 'Abdominal Pain-follow-Jaundice', 'Jaundice-assess-Urinary Incontinence', 'Jaundice-diagnose-Cholangitis', 'Urinary Incontinence-diagnose-Cholangitis', 'Leukemia-preceded-Myelodysplastic Syndromes', 'Diabetes Mellitus-related-Cardiovascular Diseases', 'Heart Rupture-associated-Death', 'Death-associated-Heart Rupture', 'Peptic Ulcer-observed-Infections', 'Inflammation-operate-Multiple Sclerosis', 'Neurodegenerative Diseases-operate-Multiple Sclerosis', 'Sleep Wake Disorders-accompanied-Cardiovascular Diseases', 'Death-result-Congenital Abnormalities', 'Erectile Dysfunction-appear-Cardiovascular Diseases', 'Purpura, Thrombocytopenic, Idiopathic-present-Chronic Disease', 'Infections-include-Onychomycosis', 'Arbovirus Infections-cause-Death', 'Wounds and Injuries-considered-Dental Occlusion, Traumatic', 'Peptic Ulcer-include-Digestive System Neoplasms', 'Stomach Neoplasms-include-Digestive System Neoplasms', 'Inflammatory Bowel Diseases-include-Digestive System Neoplasms', 'Neoplasms-related-Inflammatory Bowel Diseases', 'Neutropenia-develop-Fever', 'Uveitis-caused-Ocular Hypertension', 'Carcinoma, Squamous Cell-defined-Neoplasm Metastasis', 'Carcinoma, Squamous Cell-experience-Death', 'Death-experience-Tachycardia, Atrioventricular Nodal Reentry', 'Anemia-define-Death', 'Chronic Disease-highlighted-Alzheimer Disease', 'Muscular Diseases-attenuate-Atrophy', 'Brain Diseases-suffer-Aneurysm', 'Neurodegenerative Diseases-related-Arteriosclerosis', 'Hearing Loss-correlate-Hearing Disorders', 'Cerebrovascular Disorders-associated-Hearing Loss', 'Hearing Loss-associated-Cerebrovascular Disorders', 'Heart Failure-rule-Dyspnea', 'Acquired Immunodeficiency Syndrome-classified-Chronic Disease', 'Acquired Immunodeficiency Syndrome-viewed-Death', 'Adrenal Insufficiency-address-Malabsorption Syndromes', 'Infections-reach-Neoplasms', 'Immunologic Deficiency Syndromes-predict-Metabolic Syndrome', 'Parkinson Disease-compare-Agnosia', 'Death-classified-Epilepsy', 'Death-occur-Seizures', 'Seizures-include-Death', 'Obesity-combined-Chronic Disease', 'Epilepsy-include-Intellectual Disability', 'Epilepsy-include-Cerebral Palsy', 'Death-affected-Epilepsy', 'Death-cause-Epilepsy', 'Death-cause-Pneumonia', 'Death-excluded-Brain Neoplasms', 'Death-found-Seizures', 'Epilepsy-excluded-Brain Neoplasms', 'Pneumonia-excluded-Brain Neoplasms', 'Cerebrovascular Disorders-excluded-Brain Neoplasms', 'Neoplasms-excluded-Brain Neoplasms', 'Sexual Dysfunction, Physiological-include-Cardiovascular Diseases', 'Sexual Dysfunction, Physiological-include-Diabetes Mellitus', 'Obesity-prevent-Sexual Dysfunction, Physiological', 'Wounds and Injuries-become-Cardiovascular Diseases', 'Anemia-seen-Death', 'Hypogonadism-diagnose-Erectile Dysfunction', 'Congenital Abnormalities-include-Death', 'Dental Caries-include-Death', 'Status Epilepticus-used-Epilepsy', 'Status Epilepticus-used-Coma', 'Status Epilepticus-include-Coma', 'Status Epilepticus-defined-Epilepsy', 'Status Epilepticus-defined-Seizures', 'Seizures-defined-Epilepsy', 'Death-decline-Lung Neoplasms', 'Death-rising-Neoplasms', 'Heart Diseases-rising-Neoplasms', 'Neoplasms-considered-Genetic Diseases, Inborn', 'Aneuploidy-known-Neoplasms', 'Seizures-improve-Epilepsy', 'Parkinson Disease, Secondary-differ-Parkinsonian Disorders', 'Exanthema-last-Rubella', 'Respiratory Tract Diseases-include-Infections', 'Myasthenia Gravis-evaluated-Respiratory Insufficiency', 'Stroke-derive-Venous Thrombosis', 'Atrial Fibrillation-derive-Venous Thrombosis', 'Alzheimer Disease-show-Aneurysm', 'Cardiovascular Abnormalities-progress-Dementia, Vascular', 'Neoplasms-obtained-Skin Neoplasms', 'Pneumococcal Infections-use-Meningitis', 'Keratitis-tend-Ulcer', 'Diabetes Mellitus, Type 1-found-Infections', 'Diabetes Mellitus, Type 1-found-Death', 'Diabetes Mellitus, Type 1-found-Hypertension', 'Infections-found-Hypertension', 'Death-found-Hypertension', 'Shock, Septic-induce-Ventricular Fibrillation', 'Pneumococcal Infections-acquire-Pneumonia', 'Melioidosis-involve-Empyema', 'Weight Loss-decrease-Muscular Atrophy', 'Myositis-characterised-Muscle Weakness', 'Muscle Weakness-characterised-Muscular Diseases', 'Neuronal Ceroid-Lipofuscinoses-characterized-Abnormalities, Drug-Induced', 'Neuronal Ceroid-Lipofuscinoses-characterized-Seizures', 'Neuronal Ceroid-Lipofuscinoses-characterized-Death', 'Heredodegenerative Disorders, Nervous System-characterized-Abnormalities, Drug-Induced', 'Heredodegenerative Disorders, Nervous System-characterized-Seizures', 'Heredodegenerative Disorders, Nervous System-characterized-Death', 'Leukemia, Lymphoid-characterised-Lymphocytosis', 'Neoplastic Syndromes, Hereditary-characterised-Lymphocytosis', 'Kidney Failure, Chronic-undergo-Ischemia', 'Pain-prevent-Osteoporosis', 'Pain-prevent-Fractures, Bone', 'Ulcer-infected-Infections', 'Atrial Fibrillation-minimized-Heart Failure', 'Coronary Artery Disease-minimized-Heart Failure', 'Pericardial Effusion-reported-Pleural Effusion', 'Pericardial Effusion-reported-Polymyalgia Rheumatica', 'Weight Loss-reduce-Metabolic Syndrome', 'Weight Loss-reduce-Glucose Intolerance', 'Metabolic Syndrome-reduce-Glucose Intolerance', 'Carcinoma, Non-Small-Cell Lung-treat-Drug-Related Side Effects and Adverse Reactions', 'Calcinosis-cause-Rupture', 'Hypotension-related-Memory Disorders', 'Short Bowel Syndrome-include-Constipation', 'Constipation-assess-Colonic Neoplasms', 'Constipation-assess-Rectal Diseases', 'Parkinson Disease-live-Vision Disorders', 'Fractures, Bone-prevent-Immunologic Deficiency Syndromes', 'Fractures, Bone-prevent-Hyperparathyroidism, Secondary', 'Arthritis, Rheumatoid-live-Vision Disorders', 'Cardiac Output, Low-fall-Musculoskeletal Diseases', 'Memory Disorders-examined-Dementia', 'Ischemia-compare-Nerve Degeneration', 'Fractures, Bone-fixed-Miosis', 'Nocturia-associated-Kidney Diseases', 'Kidney Diseases-associated-Nocturia', 'Nocturia-associated-Stroke', 'Stroke-associated-Nocturia', 'Osteonecrosis-indicate-Death', 'Osteonecrosis-indicate-Hypotension', 'Death-indicate-Hypotension', 'Werner Syndrome-characterized-Diabetes Mellitus, Type 2', 'Werner Syndrome-characterized-Cataract', 'Genetic Diseases, Inborn-characterized-Diabetes Mellitus, Type 2', 'Death-confined-Cardiovascular Diseases', 'Chronic Pain-lead-Muscular Atrophy', 'Death-occur-Subarachnoid Hemorrhage', 'Muscular Diseases-reconcile-Protein-Energy Malnutrition', 'Carcinoma, Pancreatic Ductal-develop-Cervical Intraepithelial Neoplasia', 'Hypertension-controlled-Cardiovascular Diseases', 'Cervical Intraepithelial Neoplasia-identified-Carcinoma, Acinar Cell', 'Cervical Intraepithelial Neoplasia-identified-Neoplasms, Cystic, Mucinous, and Serous', 'Cervical Intraepithelial Neoplasia-identified-Pancreatic Neoplasms', 'Cervical Intraepithelial Neoplasia-identified-Cystadenoma, Serous', 'Cervical Intraepithelial Neoplasia-identified-Neoplasms', 'Hyperlipidemias-continue-Cardiovascular Diseases', 'Hyperlipidemias-continue-Coronary Artery Disease', 'Reflex, Abnormal-obscure-Polyneuropathies', 'Inflammation-lead-Digestive System Neoplasms', 'Neoplasms-continue-Infections', 'Memory Disorders-noted-Alzheimer Disease', "Sjogren's Syndrome-characterised-Xerostomia", "Sjogren's Syndrome-characterised-Dry Eye Syndromes", 'Fractures, Bone-assess-Osteoporosis', 'Pituitary Neoplasms-require-Adenomatous Polyposis Coli', 'Prolactinoma-proposed-Central Nervous System Diseases', 'Abnormalities, Drug-Induced-improve-Cardiovascular Diseases', 'Cardiovascular Diseases-ameliorated-Inflammation', 'Metabolic Syndrome-ameliorated-Inflammation', 'Hypertension-ameliorated-Inflammation', 'Diabetes Mellitus-ameliorated-Inflammation', 'Hyperlipidemias-ameliorated-Inflammation', 'Pneumococcal Infections-reduce-Pneumonia', 'Pneumococcal Infections-reduce-Infections', 'Fibrosis-stimulate-Hypertrophy', 'Urinary Incontinence-associated-Arthritis', 'Arthritis-associated-Urinary Incontinence', 'Urinary Incontinence-associated-Sleep Apnea Syndromes', 'Sleep Apnea Syndromes-associated-Urinary Incontinence', 'Prader-Willi Syndrome-share-Muscle Hypotonia', 'Respiratory Distress Syndrome-include-Lung Diseases', 'Cystic Fibrosis-include-Lung Diseases', 'Neoplasms-include-Lung Diseases', 'Atherosclerosis-increase-Myocardial Infarction', 'Agnosia-lower-Alzheimer Disease', 'Hip Fractures-caused-Wounds and Injuries', 'Hearing Loss-lead-Deafness', 'Respiratory Syncytial Virus Infections-include-Lung Injury', 'Respiratory Syncytial Virus Infections-include-Heart Diseases', 'Respiratory Syncytial Virus Infections-include-Cystic Fibrosis', 'Respiratory Syncytial Virus Infections-include-Lung Diseases', 'Respiratory Syncytial Virus Infections-include-Immunologic Deficiency Syndromes', 'Nervous System Diseases-include-Memory Disorders', 'Nervous System Diseases-affect-Memory Disorders', 'Nervous System Diseases-include-Cerebral Infarction', 'Nervous System Diseases-affect-Cerebral Infarction', 'Nervous System Diseases-affect-Parkinson Disease', 'Nervous System Diseases-affect-Alzheimer Disease', 'Dementia-improve-Alzheimer Disease', 'Neoplasms-mimic-Hyperplasia', 'Adenocarcinoma-correlated-Papilloma', 'Adenocarcinoma-use-Neoplasms', 'Anemia-reviewed-Chronic Disease', 'Hemolysis-associated-Blood Coagulation Disorders', 'Blood Coagulation Disorders-associated-Hemolysis', 'Hemolysis-produce-Blood Coagulation Disorders', 'Hemolysis-associated-Rhinitis, Vasomotor', 'Rhinitis, Vasomotor-associated-Hemolysis', 'Hemolysis-lead-Rhinitis, Vasomotor', 'Hypertension, Pulmonary-emerging-Death', 'Hypertension, Pulmonary-emerging-Thalassemia', 'Hypertension, Pulmonary-emerging-Anemia, Hemolytic', 'Blood Coagulation Disorders-lead-Rhinitis, Vasomotor', 'Blood Coagulation Disorders-produce-Basal Ganglia Cerebrovascular Disease', 'Blood Coagulation Disorders-produce-Hypertension, Pulmonary', 'Rhinitis, Vasomotor-produce-Basal Ganglia Cerebrovascular Disease', 'Hypertension, Pulmonary-associated-Anemia, Sickle Cell', 'Anemia, Sickle Cell-associated-Hypertension, Pulmonary', 'Heart Arrest-include-Death', 'Osteoarthritis-undertaken-Pain', 'Death-triple-Heart Failure', 'Heart Failure-associated-Cerebral Infarction', 'Cerebral Infarction-associated-Heart Failure', 'Hypertension-occur-Atrial Fibrillation', 'Hypertension-occur-Heart Failure', 'Cerebrovascular Disorders-associated-Cerebral Infarction', 'Cerebral Infarction-associated-Cerebrovascular Disorders', 'Cerebral Infarction-associated-Hyperlipidemias', 'Hyperlipidemias-associated-Cerebral Infarction', 'Cerebrovascular Disorders-coexist-Alzheimer Disease', 'Cerebrovascular Disorders-coexist-Dementia, Vascular', 'Hip Fractures-acquire-Infections', 'Infections-acquire-Hip Fractures', 'Fractures, Bone-cited-Thalassemia', 'Thalassemia-used-Anodontia', 'Thalassemia-include-Anodontia', 'von Willebrand Diseases-account-Hemorrhage', 'Pneumonia-precede-Death', 'Respiratory Insufficiency-precede-Death', 'Pain-exhibit-Hallux Valgus', 'Pain-report-Osteoarthritis', 'Hematologic Diseases-increased-Neutropenia', 'Heart Arrest-emerge-Neoplasms', 'Atrial Fibrillation-linked-Obesity', 'Atrial Fibrillation-correlate-Heterotaxy Syndrome', 'Obesity-correlate-Heterotaxy Syndrome', 'Atrial Fibrillation-include-Pulmonary Disease, Chronic Obstructive', 'Atrial Fibrillation-include-Aneurysm', 'Atrial Fibrillation-incorporate-Obesity', 'Vision Disorders-predict-Fatigue', 'Kidney Diseases-change-Acidosis, Lactic', 'Heart Diseases-change-Acidosis, Lactic', 'Death-undergo-Hernia, Femoral', 'Kidney Failure, Chronic-ascribed-Atherosclerosis', 'Kidney Failure, Chronic-ascribed-Arteriosclerosis', 'Arteriosclerosis-characterized-Hypertrophy', 'Kidney Failure, Chronic-characterized-Hypertrophy', 'Vascular Remodeling-identify-Death', 'Osteoarthritis-improve-Coronary Artery Disease', 'Vascular Remodeling-identify-Kidney Failure, Chronic', 'Prostatic Neoplasms-increase-Neoplasms', 'Gallstones-gained-Death', 'Neurotoxicity Syndromes-linked-Parkinson Disease', 'Neurotoxicity Syndromes-include-Parkinson Disease', 'Periodontal Diseases-categorized-Gingivitis', 'Dementia-attributed-Brain Injuries, Traumatic', 'Calculi-found-Leukoplakia', 'Sleep Initiation and Maintenance Disorders-show-Parkinson Disease', 'Sleep Initiation and Maintenance Disorders-fail-Parkinson Disease', 'Neurotoxicity Syndromes-include-Neurodegenerative Diseases', 'Neurotoxicity Syndromes-implicated-Neurodegenerative Diseases', 'Dementia-show-Cardiovascular Diseases', 'Pain-associated-Hyperkeratosis, Epidermolytic', 'Hyperkeratosis, Epidermolytic-associated-Pain', 'Lung Diseases-associated-Urinary Incontinence, Stress', 'Urinary Incontinence, Stress-associated-Lung Diseases', 'Stroke-associated-Urinary Incontinence, Stress', 'Urinary Incontinence, Stress-associated-Stroke', 'Smoke Inhalation Injury-decrease-Death', 'Death-increase-Smoke Inhalation Injury', 'Mouth Diseases-prevent-Dementia', 'Ischemia-result-Myocardial Infarction', 'Coronary Occlusion-result-Myocardial Infarction', 'Dementia-distinguished-Delirium', 'Angina, Unstable-associated-Ventricular Dysfunction', 'Ventricular Dysfunction-associated-Angina, Unstable', 'Angina, Unstable-associated-Infarction', 'Infarction-associated-Angina, Unstable', 'Angina, Unstable-associated-Arrhythmias, Cardiac', 'Arrhythmias, Cardiac-associated-Angina, Unstable', 'Muscular Dystrophies-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-Muscular Dystrophies', 'Muscular Dystrophies-associated-Cardiomyopathies', 'Cardiomyopathies-associated-Muscular Dystrophies', 'Muscular Dystrophies-associated-Arrhythmias, Cardiac', 'Arrhythmias, Cardiac-associated-Muscular Dystrophies', 'Fasciculation-contribute-Heart Diseases', 'Cardiovascular Diseases-accompany-Muscular Dystrophies', 'Fractures, Bone-occur-Inflammatory Bowel Diseases', 'Memory Disorders-refer-Alzheimer Disease', 'Shock, Septic-recover-Bone Marrow Diseases', 'Pneumonia-recover-Bone Marrow Diseases', 'Neutropenia-encountered-Anorexia', 'Neutropenia-encountered-Nausea', 'Alzheimer Disease-compare-Neurodegenerative Diseases', 'Vision, Low-reduce-Ocular Motility Disorders', 'Metabolic Diseases-associated-Death', 'Death-associated-Metabolic Diseases', 'Hyponatremia-result-Inappropriate ADH Syndrome', 'Hyponatremia-reported-Neoplasms', 'Hyponatremia-represent-Paraneoplastic Syndromes', 'Carcinoma, Squamous Cell-admitted-Hyponatremia', 'Carcinoma, Squamous Cell-result-Inappropriate ADH Syndrome', 'Inappropriate ADH Syndrome-explained-Neoplasms', 'Inappropriate ADH Syndrome-explained-Neoplasm Metastasis', 'Leukoencephalopathies-seen-Coronary Artery Disease', 'Neoplasms-diagnosed-Aneurysm', 'Hyperplasia-expected-Mastocytosis, Systemic', 'Fractures, Bone-produce-Pain', 'Musculoskeletal Diseases-obtain-Pain', 'Death-adjudicated-Cardiovascular Diseases', 'Cardiovascular Diseases-assigned-Death', 'Death-prevent-Cardiovascular Diseases', 'Coronary Artery Disease-prevent-Cardiovascular Diseases', 'Myocardial Infarction-prevent-Cardiovascular Diseases', 'Ankle Fractures-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-Ankle Fractures', 'Ankle Fractures-associated-Peripheral Vascular Diseases', 'Peripheral Vascular Diseases-associated-Ankle Fractures', 'Cleft Palate-follow-Rhinitis, Allergic', 'Metabolic Syndrome-represent-Lipodystrophy', 'Hearing Loss, Central-hear-Hearing Loss', 'Hyperplasia-demonstrate-Hypertrophy', 'Hip Fractures-compare-Pneumonia', 'Death-compared-Neoplasm Invasiveness', 'Parkinson Disease-followed-Death', 'Dementia-fulfil-Alzheimer Disease', 'Hemoptysis-associated-Pulmonary Embolism', 'Pulmonary Embolism-associated-Hemoptysis', 'Tachycardia-associated-Pulmonary Embolism', 'Pulmonary Embolism-associated-Tachycardia', 'Pleural Effusion-associated-Pulmonary Embolism', 'Pulmonary Embolism-associated-Pleural Effusion', 'Venous Thrombosis-associated-Pulmonary Embolism', 'Pulmonary Embolism-associated-Venous Thrombosis', 'Nephritis-cause-Kidney Diseases', 'Hypotension, Orthostatic-decreased-Headache', 'Neuronal Ceroid-Lipofuscinoses-constitute-Nervous System Diseases', 'Neoplasms-increase-Infections', 'Neoplasms-alter-Sepsis', 'Osteoarthritis-result-Pain', 'Wounds and Injuries-alter-Sepsis', 'Kidney Diseases-associated-Cerebrovascular Disorders', 'Cerebrovascular Disorders-associated-Kidney Diseases', 'Kidney Diseases-associated-Brain Infarction', 'Brain Infarction-associated-Kidney Diseases', 'Hypoglycemia-seen-Diabetes Mellitus', 'Diabetes Mellitus-hast-Dementia', 'Diabetes Mellitus-obscured-Hypertension', 'Diabetes Mellitus-obscured-Cerebrovascular Disorders', 'Cerebrovascular Disorders-occur-Diabetes Mellitus', 'Hypoxia-result-Hypercapnia', 'Vascular System Injuries-lead-Atherosclerosis', 'Ventricular Fibrillation-monitor-Cataract', 'Coronary Artery Disease-result-Heart Diseases', 'Aortic Valve Stenosis-result-Heart Diseases', 'Prostatic Hyperplasia-visit-Hematuria', 'Ventricular Dysfunction-characterize-Heart Failure', 'Death-underlie-Neoplasms', 'Ventricular Dysfunction-reverse-Neurologic Manifestations', 'Osteoporosis-increase-Breast Neoplasms', 'Osteoporosis-increase-Venous Thrombosis', 'Osteoporosis-increase-Stroke', 'Osteoporosis-increase-Coronary Artery Disease', 'Fractures, Bone-take-Bone Diseases, Metabolic', 'Fractures, Bone-take-Osteoporotic Fractures', 'Osteoporosis-considered-Oculocerebrorenal Syndrome', 'Dementia-based-Nervous System Diseases', 'Alzheimer Disease-based-Nervous System Diseases', 'Neoplasms-consist-Aneuploidy', 'Weight Loss-suggest-Cardiovascular Diseases', 'Aneurysm-cause-Chronic Disease', 'Aneurysm-cause-Prostatic Hyperplasia', 'Aneurysm-cause-Erectile Dysfunction', 'Chronic Disease-cause-Prostatic Hyperplasia', 'Chronic Disease-cause-Erectile Dysfunction', 'Cardiovascular Diseases-underlie-Liver Diseases', 'Infertility, Female-identify-Erectile Dysfunction', 'Psychomotor Disorders-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-Psychomotor Disorders', 'Prostatic Hyperplasia-lead-Infections', 'Prostatic Hyperplasia-lead-Kidney Diseases', 'Prostatic Hyperplasia-found-Airway Obstruction', 'Tremor-detected-Heredodegenerative Disorders, Nervous System', 'Muscle Rigidity-detected-Heredodegenerative Disorders, Nervous System', 'Hypokinesia-detected-Heredodegenerative Disorders, Nervous System', 'Parkinsonian Disorders-detected-Heredodegenerative Disorders, Nervous System', 'Mucopolysaccharidosis III-detected-Heredodegenerative Disorders, Nervous System', 'Osteoporosis-treat-Erectile Dysfunction', 'Primary Myelofibrosis-characterized-Anemia', 'Primary Myelofibrosis-characterized-Splenomegaly', 'Amnesia-diagnosed-Dementia', 'Obesity-become-Death', 'Obesity-rivale-Death', 'Obesity-rivale-Neoplasms', 'Obesity-associated-Hypercholesterolemia', 'Hypercholesterolemia-associated-Obesity', 'Obesity-associated-Arthritis', 'Arthritis-associated-Obesity', 'Dyskeratosis Congenita-result-Abnormalities, Multiple', 'Dyskeratosis Congenita-result-Bone Marrow Failure Disorders', 'Dyskeratosis Congenita-result-Neoplasms', 'Hypertriglyceridemia-associated-Musculoskeletal Diseases', 'Musculoskeletal Diseases-associated-Hypertriglyceridemia', 'Death-assessed-Wounds and Injuries', 'Autoimmune Diseases-developed-Arthritis', 'Autoimmune Diseases-developed-Glomerulonephritis', 'Autoimmune Diseases-developed-Pneumonia', 'Arthritis-developed-Glomerulonephritis', 'Infections-associated-Hemorrhage', 'Hemorrhage-associated-Infections', 'Peptic Ulcer-show-Death', 'Ulcer-show-Death', 'Diarrhea-follow-Headache', 'Nausea-follow-Headache', 'Vomiting-follow-Headache', 'Hyperglycemia-characterize-Diabetes Mellitus', 'White Dot Syndromes-involve-Retinal Detachment', 'Fatigue-occur-Neoplasms', 'Hematologic Diseases-reported-Anemia', 'Hematologic Diseases-reported-Leukopenia', 'Hematologic Diseases-reported-Thrombocytopenia', 'Hematologic Diseases-reported-Pancytopenia', 'Communicable Diseases-promote-Dementia', 'Diabetes Mellitus-create-Fistula', 'Atherosclerosis-create-Fistula', 'Epilepsy-mimic-Seizures', 'Stroke-use-Atrial Fibrillation', 'Stroke-use-Diabetes Mellitus', 'Stroke-use-Hypertension', 'Craniocerebral Trauma-continue-Hepatitis C', 'Alzheimer Disease-suffer-Sleep Wake Disorders', 'Bacterial Infections-predict-Death', 'Heart Failure-conduct-Fatigue', 'Obesity-lead-Musculoskeletal Diseases', 'Alzheimer Disease-exhibit-Cerebrovascular Disorders', 'Aneurysm-consider-Alzheimer Disease', 'Stroke-related-Carotid Artery Diseases', 'Stroke-prevent-Constriction, Pathologic', 'Pain-associated-Asthma', 'Asthma-associated-Pain', 'Neoplasm Metastasis-base-Carcinoma, Squamous Cell', 'Neoplasm Metastasis-defined-Carcinoma, Squamous Cell', 'Carcinoma, Squamous Cell-associated-Tachycardia, Atrioventricular Nodal Reentry', 'Tachycardia, Atrioventricular Nodal Reentry-associated-Carcinoma, Squamous Cell', 'Carcinoma, Squamous Cell-associated-Neoplasm Metastasis', 'Neoplasm Metastasis-associated-Carcinoma, Squamous Cell', 'Kidney Failure, Chronic-develop-Status Epilepticus', 'Adrenal Insufficiency-associated-Hyperhomocysteinemia', 'Hyperhomocysteinemia-associated-Adrenal Insufficiency', 'Retinal Diseases-assessed-Diabetes Mellitus', 'Microaneurysm-assessed-Diabetes Mellitus', 'Hemorrhage-assessed-Diabetes Mellitus', 'Seizures-present-Spasm', 'Myelodysplastic Syndromes-prevent-Hypercalcemia', 'Myelodysplastic Syndromes-associated-Pancytopenia', 'Pancytopenia-associated-Myelodysplastic Syndromes', 'Myelodysplastic Syndromes-associated-Cardiomyopathies', 'Cardiomyopathies-associated-Myelodysplastic Syndromes', 'Anemia, Pernicious-associated-Pancytopenia', 'Pancytopenia-associated-Anemia, Pernicious', 'Anemia, Pernicious-associated-Cardiomyopathies', 'Cardiomyopathies-associated-Anemia, Pernicious', 'Facial Dermatoses-caused-Acne Vulgaris', 'Facial Dermatoses-caused-Wounds and Injuries', 'Skin Diseases-affect-Diabetes Mellitus', 'Death-shown-Pulmonary Disease, Chronic Obstructive', 'Communicable Diseases-used-Alzheimer Disease', 'Atherosclerosis-estimated-Erectile Dysfunction', 'Peripheral Nervous System Diseases-result-Erectile Dysfunction', 'Back Pain-result-Pain', 'Death-vary-Pneumonia', 'Memory Disorders-followed-Alzheimer Disease', 'Liver Diseases-carry-Osteoporosis', 'Liver Diseases-carry-Bone Neoplasms', 'Atherosclerosis-account-Renal Artery Obstruction', 'Renal Artery Obstruction-account-Fibromuscular Dysplasia', 'Atherosclerosis-associated-Aneurysm', 'Aneurysm-associated-Atherosclerosis', 'Hypertension-improve-Sleep Wake Disorders', 'Leukemia, Lymphocytic, Chronic, B-Cell-identified-Drug-Related Side Effects and Adverse Reactions', 'Leukemia-identified-Anemia', 'Leukemia, Lymphocytic, Chronic, B-Cell-identified-Anemia', 'Neoplasms-identified-Anemia', 'Cardiovascular Diseases-experience-Death', 'Wounds and Injuries-associated-Musculoskeletal Diseases', 'Musculoskeletal Diseases-associated-Wounds and Injuries', 'Skin Diseases-resemble-Xeroderma Pigmentosum', 'Hyperpigmentation-resemble-Xeroderma Pigmentosum', 'Skin Neoplasms-resemble-Xeroderma Pigmentosum', 'Arthritis-comprise-Arthritis, Rheumatoid', 'Arthritis, Rheumatoid-comprise-Rheumatic Fever', 'Alzheimer Disease-improve-Drug-Related Side Effects and Adverse Reactions', 'Parkinson Disease-improve-Drug-Related Side Effects and Adverse Reactions', 'Diabetes Mellitus-exacerbate-Urinary Incontinence', 'Diabetes Mellitus-complicate-Gout', 'Anemia-correlated-Kidney Diseases', 'Diabetes Mellitus-assess-Myocardial Infarction', 'Angina Pectoris-identified-Stroke', 'Heart Failure-lead-HIV Infections', 'Heart Failure-lead-Diabetes Mellitus', 'Neuroblastoma-protect-Death', 'Gaucher Disease-compare-Melanoma', 'Periodontitis-cause-Hyperlipidemias', 'Hyperlipidemias-cause-Cardiovascular Diseases', 'Stomach Neoplasms-carried-Neoplasms', 'Autoimmune Diseases-show-Motor Neuron Disease', 'Motor Neuron Disease-resemble-Autoimmune Diseases', 'Reperfusion Injury-occur-Shock, Hemorrhagic', 'Reperfusion Injury-lead-Death', 'Dyspnea-done-Death', 'Dyspnea-contribute-Death', 'Hearing Loss, Bilateral-found-Kidney Diseases', 'Constriction, Pathologic-observed-Diabetes Mellitus', 'Ischemia-observed-Diabetes Mellitus', 'Retinal Diseases-defined-Hemorrhage', 'Retinal Diseases-defined-Microaneurysm', 'Retinal Diseases-defined-Retinal Arterial Macroaneurysm', 'Pain-followed-Edema', 'Diabetes Mellitus-show-Retinal Diseases', 'Hypertension-show-Retinal Diseases', 'Proteinuria-show-Retinal Diseases', 'Microvascular Angina-associated-Kidney Diseases', 'Kidney Diseases-associated-Microvascular Angina', 'Parkinson Disease-evaluate-Hypokinesia', 'Neutropenia-consist-Bone Marrow Diseases', 'Neutropenia-exceed-Neoplasms', 'Thrombocytopenia-consist-Bone Marrow Diseases', 'Thrombocytopenia-exceed-Neoplasms', 'Bone Marrow Diseases-exceed-Neoplasms', 'Neurodegenerative Diseases-caused-Alzheimer Disease', 'Venous Thromboembolism-defined-Venous Thrombosis', 'Venous Thromboembolism-defined-Pulmonary Embolism', 'Hip Fractures-belong-Death', 'Carcinoma, Non-Small-Cell Lung-questioned-Multiple Organ Failure', 'Drug-Related Side Effects and Adverse Reactions-questioned-Carcinoma, Non-Small-Cell Lung', 'Thrombosis-experience-Headache', 'Diabetes Mellitus-found-Stroke', 'Diabetes Mellitus-improve-Cerebral Infarction', 'Hypertension-noted-Atherosclerosis', 'Atherosclerosis-predict-Hypertension', 'Atherosclerosis-predict-Diabetes Mellitus', 'Osteoporotic Fractures-evaluated-Fractures, Bone', 'Calcinosis-speculated-Stroke', 'Calcinosis-investigate-Stroke', 'Carotid Artery Diseases-investigate-Stroke', 'Brain Ischemia-investigate-Stroke', 'Atherosclerosis-investigate-Stroke', 'Calcinosis-related-Cerebrovascular Disorders', 'Calcinosis-related-Arteriosclerosis', 'Calcinosis-related-Stroke', 'Calcinosis-cause-Stroke', 'Arteriosclerosis-cause-Stroke', 'Eunuchism-include-Pathological Conditions, Anatomical', 'Eunuchism-include-Infections', 'Eunuchism-include-Neoplasms', 'Hypothalamic Neoplasms-result-Diabetes Mellitus, Type 2', 'Hypogonadism-include-Oligospermia', 'Hypogonadism-include-Azoospermia', 'Hypogonadism-include-Muscular Atrophy', 'Pain-cause-Osteoporosis', 'Syncope-referred-Trigeminal Neuralgia', 'Parkinson Disease, Secondary-complicated-Psychoses, Substance-Induced', 'Parkinson Disease, Secondary-develop-Dementia', 'Heart Failure, Systolic-contribute-Ventricular Fibrillation', 'Heart Failure, Systolic-contribute-Heart Diseases', 'Alzheimer Disease-show-Amnesia', 'Atherosclerosis-terminate-Angina Pectoris', 'Diabetes Mellitus-contract-Infections', 'Nocturia-caused-Polyuria', 'Polyuria-include-Nocturia', 'Urinary Bladder, Overactive-include-Nocturia', 'Cough-increase-Pneumonia', 'Cerebrovascular Disorders-increase-Pneumonia', 'Cough-result-Pneumonia', 'Ischemia-illustrate-Abdominal Pain', 'Ischemia-illustrate-Arterial Occlusive Diseases', 'Hypogonadism-predict-Erectile Dysfunction', 'Hypogonadism-use-Erectile Dysfunction', 'Multiple Organ Failure-found-Cardiovascular Diseases', 'Multiple Organ Failure-found-Respiratory Tract Diseases', 'Multiple Organ Failure-found-Gastrointestinal Diseases', 'Multiple Organ Failure-found-Cerebrovascular Disorders', 'Death-found-Cardiovascular Diseases', 'Death-found-Respiratory Tract Diseases', 'Death-found-Gastrointestinal Diseases', 'Diabetes Mellitus-become-Anemia', 'Hypertension-become-Anemia', 'Intracranial Aneurysm-include-Aneurysm', 'Cerebrovascular Disorders-manifest-Atherosclerosis', 'Nocturia-defined-Sleep Wake Disorders', 'Nocturia-follow-Sleep Wake Disorders', 'Cerebral Infarction-include-Thromboembolism', 'Cerebral Infarction-include-Pulmonary Embolism', 'Thromboembolism-include-Obesity', 'Pain-complete-Osteoarthritis', 'Airway Obstruction-use-Pulmonary Disease, Chronic Obstructive', 'Dementia-complicated-Psychoses, Substance-Induced', 'Creutzfeldt-Jakob Syndrome-understood-Adrenal Insufficiency', 'Renal Insufficiency-coexist-Heart Failure', 'Mucocutaneous Lymph Node Syndrome-linked-Infections', 'Mucocutaneous Lymph Node Syndrome-linked-IgA Vasculitis', 'Delirium-preexist-Cardiovascular Diseases', 'Diabetes Mellitus-affect-Fractures, Bone', 'Glucose Intolerance-affect-Fractures, Bone', 'Coronary Artery Disease-compare-Headache Disorders, Secondary', 'Polycythemia-Monitoring-Prostatic Diseases', 'Hypogonadism-account-Diabetes Mellitus', 'Hypogonadism-account-Cardiovascular Diseases', 'Hypogonadism-account-Hypertension', 'Hypogonadism-account-Obesity', 'Virilism-consist-Erectile Dysfunction', 'Virilism-consist-Lethargy', 'Bone Diseases, Metabolic-develop-Fractures, Bone', 'Bone Diseases, Metabolic-loose-Diabetes Mellitus', 'Fractures, Bone-loose-Diabetes Mellitus', 'Fractures, Bone-develop-Coronary Artery Disease', 'Brain Diseases-cause-Dementia', 'Hypertrophy-affect-Alzheimer Disease', 'Cerebrovascular Disorders-cause-Dementia', 'Pain-occur-Syncope', 'Vestibular Diseases-fall-Cardiac Output, Low', 'Infections-include-Cough', 'Infections-include-Fever', 'Pneumonia-related-Infections', 'Osteoarthritis-determined-Sclerosis', 'Immunologic Deficiency Syndromes-associated-Hemorrhage', 'Hemorrhage-associated-Immunologic Deficiency Syndromes', 'Drug-Related Side Effects and Adverse Reactions-expressed-Blood Coagulation Disorders', 'Fractures, Bone-incur-Nervous System Diseases', 'Syncope-impair-Osteoporotic Fractures', 'Osteoporosis-accelerate-Fractures, Bone', 'Intellectual Disability-followed-Chronic Disease', 'Fractures, Stress-based-Sclerosis', 'Fractures, Stress-surrounded-Sclerosis', 'Arthritis-access-Thrombosis', 'Arthritis-access-Urinary Incontinence', 'Stroke-represent-Death', 'Ovarian Diseases-undergo-Pulmonary Atresia', 'Death-show-Myocardial Infarction', 'Dehydration-linked-Infections', 'Dehydration-linked-Death', 'Dehydration-lead-Vision Disorders', 'Neurologic Manifestations-address-Musculoskeletal Diseases', 'Brain Ischemia-progress-Stroke', 'Leukoencephalopathies-progress-Stroke', 'Infarction-progress-Stroke', 'Diabetes Mellitus-conducted-Chronic Disease', 'Brain Ischemia-associated-Stroke', 'Stroke-associated-Brain Ischemia', 'Aneurysm-involved-Obesity', 'Teratoma-replace-Immunologic Deficiency Syndromes', 'Pancreatic Diseases-recorded-Fibrosis', 'Osteoporosis-prevent-Bone Neoplasms', 'Werner Syndrome-develop-Drug-Related Side Effects and Adverse Reactions', 'Werner Syndrome-develop-Leukemia, Myeloid, Acute', 'Drug-Related Side Effects and Adverse Reactions-develop-Leukemia, Myeloid, Acute', 'Werner Syndrome-result-Drug-Related Side Effects and Adverse Reactions', 'Dry Eye Syndromes-impair-Immunologic Deficiency Syndromes', 'Mucositis-appear-Cardiotoxicity', 'Mucositis-reported-Leukemia, Myeloid, Acute', 'Cardiotoxicity-reported-Leukemia, Myeloid, Acute', 'Drug-Related Side Effects and Adverse Reactions-reduced-Cardiotoxicity', 'Cardiotoxicity-include-Drug-Related Side Effects and Adverse Reactions', 'Diabetes Mellitus-do-Myocardial Infarction', 'Myelodysplastic Syndromes-associated-Drug-Related Side Effects and Adverse Reactions', 'Drug-Related Side Effects and Adverse Reactions-associated-Myelodysplastic Syndromes', 'Neutropenia-associated-Chronic Disease', 'Chronic Disease-associated-Neutropenia', 'Leukemia-associated-Chronic Disease', 'Chronic Disease-associated-Leukemia', 'Dementia-rule-Delirium', 'Dementia-rule-Seizures', 'Macular Degeneration-gain-Choroiditis', 'Macular Degeneration-gain-Choroid Diseases', 'Choroiditis-described-Choroid Diseases', 'Choroidal Neovascularization-remain-Blindness', 'Sensation Disorders-documented-Parkinson Disease', 'Ocular Hypertension-undergo-Retinal Diseases', 'Diabetes Mellitus-undergo-Retinal Diseases', 'Atherosclerosis-include-Diabetic Angiopathies', 'Neoplasms-found-Hodgkin Disease', 'Liver Cirrhosis-regarded-Fasciitis', 'Neoplasms-represent-Adenocarcinoma', 'Pulmonary Disease, Chronic Obstructive-become-Multiple Organ Failure', 'Erythema-outweigh-Pigmentation Disorders', 'Fractures, Bone-diagnosed-Osteoporosis', 'Hypertension-qualify-Pulmonary Disease, Chronic Obstructive', 'Hypertension-qualify-Gastrointestinal Diseases', 'Hypertension-qualify-Osteoarthritis', 'Kidney Neoplasms-lead-Gallbladder Diseases', 'Calcinosis-result-Pain', 'Neoplasms-supposed-Venous Thromboembolism', 'Neoplasms-increase-Venous Thromboembolism', 'Pelvic Neoplasms-investigated-Fractures, Bone', 'Alzheimer Disease-lost-Neurodegenerative Diseases', 'Parkinson Disease-play-Inflammation', 'Bradycardia-determined-Ventricular Premature Complexes', 'Ulcer-associated-Urinary Incontinence', 'Urinary Incontinence-associated-Ulcer', 'Dementia-become-Alzheimer Disease', 'Alzheimer Disease-needed-Dementia, Vascular', 'Diabetes Mellitus, Type 1-lower-Hypotension', 'Diabetes Mellitus, Type 1-lower-Diabetes Mellitus, Type 2', 'Alzheimer Disease-inhibit-Neurodegenerative Diseases', 'Dyskeratosis Congenita-associated-Skin Abnormalities', 'Skin Abnormalities-associated-Dyskeratosis Congenita', 'Bone Marrow Failure Disorders-associated-Skin Abnormalities', 'Skin Abnormalities-associated-Bone Marrow Failure Disorders', 'Atrophy-attenuate-Blister', 'Arthritis-include-Spondylarthropathies', 'Arthritis-associated-Spondylarthropathies', 'Spondylarthropathies-associated-Arthritis', 'Arthritis, Psoriatic-include-Spondylarthropathies', 'Inflammatory Bowel Diseases-include-Spondylarthropathies', 'Arthritis-associated-Inflammatory Bowel Diseases', 'Inflammatory Bowel Diseases-associated-Arthritis', 'Spondylarthropathies-characterised-Inflammation', 'Spondylarthropathies-characterised-Arthritis, Juvenile', 'Spondylarthropathies-characterised-Edema', 'Edema-involve-Arthritis, Juvenile', 'Pain-contribute-Psychomotor Disorders', 'Cerebral Infarction-increased-Hypertension', 'Dementia-vary-Stroke', 'Stroke-appear-Dementia', 'Stroke-identify-Dementia', 'Aneurysm-seen-Stroke', 'Ischemia-appear-Dementia', 'Aneurysm-contribute-Neurodegenerative Diseases', 'Aneurysm-contribute-Dementia', 'Infarction-appear-Dementia', 'Leukoencephalopathies-appear-Dementia', 'Stroke-contribute-Neurodegenerative Diseases', 'Stroke-seen-Dementia', 'Neurodegenerative Diseases-contribute-Dementia', 'Alzheimer Disease-arise-Dementia, Vascular', 'Cerebrovascular Disorders-arise-Dementia, Vascular', 'Atrophy-contribute-Sarcopenia', 'Death-contribute-Sarcopenia', 'Atrophy-associated-Death', 'Death-associated-Atrophy', 'Leukoaraiosis-uncomplicated-Ischemia', 'Small Cell Lung Carcinoma-require-Neoplasms', 'Alzheimer Disease-investigated-Dementia', 'Creutzfeldt-Jakob Syndrome-caused-Infections', 'Stomach Neoplasms-increase-Death', 'Dementia-related-HIV Infections', 'Headache Disorders, Secondary-related-HIV Infections', 'Alzheimer Disease-reflect-Atrophy', 'Myxedema-treated-Hypothyroidism', 'Nervous System Diseases-explain-Vision Disorders', 'Prostatic Neoplasms-detect-Uniparental Disomy', 'Purpura-reduce-Virilism', 'Pain-expected-Fractures, Bone', 'Alzheimer Disease-decrease-Neoplasms', 'Dementia, Vascular-decrease-Death', 'Dementia, Vascular-decrease-Neoplasms', 'Oculocerebrorenal Syndrome-result-Erectile Dysfunction', 'Constriction, Pathologic-classified-Musculoskeletal Diseases', 'Constriction, Pathologic-classified-Scoliosis', 'Constriction, Pathologic-lead-Intermittent Claudication', 'Constriction, Pathologic-associated-Radiculopathy', 'Radiculopathy-associated-Constriction, Pathologic', 'Intermittent Claudication-occur-Radiculopathy', 'Stroke-play-Cerebral Small Vessel Diseases', 'Neoplasms-mimic-Carcinogenesis', 'Memory Disorders-depend-Atrophy', 'Infections-promote-Dementia', 'Diabetes Mellitus-shown-Dementia', 'Venous Thromboembolism-require-Breast Neoplasms', 'Death-compare-Delirium', 'Primary Ovarian Insufficiency-included-Vulvar Neoplasms', 'Neoplasms-extend-Death', 'Cardiovascular Diseases-differ-Hypertension', 'Weight Gain-confer-Death', 'Obesity-compete-Death', 'Death-compete-Weight Loss', 'Chronic Disease-occur-Pain', 'Pain-reduced-Neoplasms', 'Pain-increase-Hypesthesia', 'Neuralgia-aggravated-Hypesthesia', 'Pain-aggravated-Hypesthesia', 'Breast Neoplasms-live-Lymphedema', 'Lymphedema-impact-Breast Neoplasms', 'Lymphedema-presented-Breast Neoplasms', 'Inflammation-obtained-Atherosclerosis', 'Hypertension, Renovascular-associated-Renal Artery Obstruction', 'Renal Artery Obstruction-associated-Hypertension, Renovascular', 'Proteinuria-associated-Renal Artery Obstruction', 'Renal Artery Obstruction-associated-Proteinuria', 'Pulmonary Edema-associated-Renal Artery Obstruction', 'Renal Artery Obstruction-associated-Pulmonary Edema', 'Aneurysm-treated-Subarachnoid Hemorrhage', 'Pain-inhibit-Pneumonia', 'Pain-inhibit-Constipation', 'Hyperlipidemias-contribute-Aneurysm', 'Pain-decrease-Venous Thrombosis', 'Hyperlipidemias-play-Dementia', 'Aneurysm-play-Dementia', 'Thrombosis-involve-Atherosclerosis', 'Silicosis-represent-Silicotuberculosis', 'Tuberculosis-represent-Silicotuberculosis', 'Candidiasis, Oral-found-Retinitis', 'Kidney Diseases-related-Renal Insufficiency, Chronic', 'Death-increase-Communicable Diseases', 'Brugada Syndrome-categorised-Arrhythmias, Cardiac', 'Brugada Syndrome-categorised-Heart Block', 'Brugada Syndrome-categorised-Bradycardia', 'Genetic Diseases, Inborn-associated-Werner Syndrome', 'Werner Syndrome-associated-Genetic Diseases, Inborn', 'Genetic Diseases, Inborn-associated-Bloom Syndrome', 'Bloom Syndrome-associated-Genetic Diseases, Inborn', 'Genetic Diseases, Inborn-associated-Rothmund-Thomson Syndrome', 'Rothmund-Thomson Syndrome-associated-Genetic Diseases, Inborn', 'Neoplasms-associated-Rothmund-Thomson Syndrome', 'Rothmund-Thomson Syndrome-associated-Neoplasms', 'Onychomycosis-treat-Diabetes Mellitus', 'Leukoencephalopathies-caused-Cerebral Small Vessel Diseases', 'Cardiovascular Diseases-result-Heart Failure', 'Brain Damage, Chronic-caused-Cerebrovascular Disorders', 'Brain Damage, Chronic-caused-Neurotoxicity Syndromes', 'Cerebrovascular Disorders-seen-Alzheimer Disease', 'Nerve Degeneration-seen-Alzheimer Disease', 'Coronary Artery Disease-linked-Dyslipidemias', 'Atherosclerosis-linked-Dyslipidemias', 'Death-reduce-Dyslipidemias', 'Immunologic Deficiency Syndromes-cause-Heart Arrest', 'Infections-characterized-Pain', 'Infections-characterized-Color Vision Defects', 'Orbital Cellulitis-develop-Gonorrhea', 'Pain-cause-Vision Disorders', 'Color Vision Defects-cause-Vision Disorders', 'Anemia-progress-Leukemia, Myeloid, Acute', 'Infections-progress-Leukemia, Myeloid, Acute', 'Hemorrhage-progress-Leukemia, Myeloid, Acute', 'Myelodysplastic Syndromes-manifest-Anemia', 'Myelodysplastic Syndromes-manifest-Neutropenia', 'Myelodysplastic Syndromes-manifest-Thrombocytopenia', 'Genetic Diseases, Inborn-manifest-Anemia', 'Genetic Diseases, Inborn-manifest-Neutropenia', 'Dementia-comprise-Infections', 'Dementia-comprise-Autoimmune Diseases', 'Genetic Diseases, Inborn-manifest-Thrombocytopenia', 'Infections-comprise-Autoimmune Diseases', 'Leukemia, Myeloid, Acute-lead-Death', 'Amnesia-incurred-Hypoxia, Brain', 'Leukemia, Myeloid, Acute-lead-Bone Marrow Failure Disorders', 'Death-lead-Bone Marrow Failure Disorders', 'Myelodysplastic Syndromes-lead-Death', 'Brain Injuries-occur-Amnesia', 'Diabetes Mellitus-study-Metabolic Diseases', 'Brain Diseases-include-Neoplasms', 'Pneumonia-include-Neoplasms', 'Dehydration-include-Neoplasms', 'Dementia-slow-Psychomotor Disorders', 'Arteriovenous Fistula-yield-Coronary Artery Disease', 'Hepatitis, Autoimmune-suspected-Thyroiditis, Autoimmune', 'Hepatitis, Autoimmune-investigate-Thyroiditis, Autoimmune', 'Hepatitis, Autoimmune-suspected-Chemical and Drug Induced Liver Injury', 'Hepatitis, Autoimmune-investigate-Chemical and Drug Induced Liver Injury', 'Kidney Diseases-accelerate-Arteriosclerosis', 'Kidney Diseases-accelerate-Hypertension', 'Fecal Incontinence-affect-Death', 'Constipation-lead-Substance-Related Disorders', 'Constipation-lead-Diarrhea', 'Constipation-lead-Neuromuscular Diseases', 'Constipation-lead-Nervous System Diseases', 'Substance-Related Disorders-lead-Fecal Incontinence', 'Diarrhea-lead-Fecal Incontinence', 'Nervous System Diseases-include-Neuromuscular Diseases', 'Neuromuscular Diseases-lead-Fecal Incontinence', 'Nervous System Diseases-lead-Fecal Incontinence', 'Pain-live-Hypertension', 'Hypotension-associated-Heart Failure, Diastolic', 'Heart Failure, Diastolic-associated-Hypotension', 'Sacroiliitis-observed-Arthritis, Juvenile', 'Myocardial Infarction-become-Hypoxia', 'Dyspnea-become-Hypoxia', 'Inflammation-manifested-Renal Insufficiency, Chronic', 'Inflammation-shown-Death', 'Diabetes Mellitus, Type 1-associated-Acute Kidney Injury', 'Acute Kidney Injury-associated-Diabetes Mellitus, Type 1', 'Diabetes Mellitus, Type 1-associated-Infections', 'Infections-associated-Diabetes Mellitus, Type 1', 'Infections-related-Urinary Tract Infections', 'Infections-cause-Neurologic Manifestations', 'Alzheimer Disease-show-Plaque, Amyloid', 'Mucocutaneous Lymph Node Syndrome-increase-Coronary Artery Disease', 'Brain Ischemia-contribute-Alzheimer Disease', 'Brain Ischemia-recognized-Ischemia', 'Dementia-underlie-Ischemia', 'Alzheimer Disease-underlie-Ischemia', 'Acquired Immunodeficiency Syndrome-result-Neoplasms', 'Congenital Abnormalities-represent-Death', 'Urinary Tract Infections-reduce-Death', 'Death-underlie-Kidney Diseases', 'Death-include-Hypotension', 'Death-underlie-Hypotension', 'Death-include-Hypoalbuminemia', 'Death-underlie-Hypoalbuminemia', 'Retinal Artery Occlusion-constitute-Blindness', 'Retinal Artery Occlusion-constitute-Vision Disorders', 'Retinal Artery Occlusion-cause-Glaucoma', 'Neoplasms-include-Zoonoses', 'Infections-include-Zoonoses', 'Retinal Artery Occlusion-cause-Glaucoma, Neovascular', 'Glaucoma-cause-Retinal Vein Occlusion', 'Glaucoma-cause-Embolism', 'Glaucoma-last-Blindness', 'Glaucoma-last-Ischemia', 'Glaucoma-cause-Retinal Artery Occlusion', 'Ischemia-cause-Glaucoma', 'Cerebral Infarction-oppose-Cerebral Hemorrhage', 'Glaucoma-occluded-Embolism', 'Cerebral Infarction-associated-Hypercholesterolemia', 'Hypercholesterolemia-associated-Cerebral Infarction', 'Hypertension-cause-Retinal Vein Occlusion', 'Cerebral Infarction-associated-Migraine Disorders', 'Migraine Disorders-associated-Cerebral Infarction', 'Cerebral Infarction-associated-Heart Diseases', 'Heart Diseases-associated-Cerebral Infarction', 'Cerebral Infarction-associated-Aneurysm', 'Aneurysm-associated-Cerebral Infarction', 'Cerebral Hemorrhage-associated-Hypercholesterolemia', 'Hypercholesterolemia-associated-Cerebral Hemorrhage', 'Hypertension-cause-Retinal Artery Occlusion', 'Cerebral Hemorrhage-associated-Migraine Disorders', 'Migraine Disorders-associated-Cerebral Hemorrhage', 'Retinal Vein Occlusion-cause-Glaucoma, Neovascular', 'Cerebral Hemorrhage-associated-Atrial Fibrillation', 'Atrial Fibrillation-associated-Cerebral Hemorrhage', 'Cerebral Hemorrhage-associated-Stroke', 'Stroke-associated-Cerebral Hemorrhage', 'Cerebral Hemorrhage-associated-Heart Diseases', 'Heart Diseases-associated-Cerebral Hemorrhage', 'Cerebral Hemorrhage-associated-Aneurysm', 'Aneurysm-associated-Cerebral Hemorrhage', 'Cardiovascular Diseases-affect-Diabetes Mellitus', 'Glaucoma, Neovascular-cause-Embolism', 'Glaucoma, Neovascular-last-Blindness', 'Glaucoma, Neovascular-last-Ischemia', 'Glaucoma, Neovascular-cause-Retinal Artery Occlusion', 'Death-evaluated-Diabetes Mellitus', 'Ischemia-cause-Glaucoma, Neovascular', 'Death-evaluated-Severe Acute Respiratory Syndrome', 'Glaucoma, Neovascular-occluded-Embolism', 'Thrombosis-occluded-Embolism', 'Sarcoma, Synovial-represent-Sarcoma', 'Sarcoma, Synovial-needed-Neoplasms', 'Hyperphosphatemia-recognized-Cardiovascular Diseases', 'Hyperphosphatemia-recognized-Death', 'Hyperphosphatemia-recognized-Kidney Failure, Chronic', 'Death-resemble-Neurodegenerative Diseases', 'Death-progress-Neurodegenerative Diseases', 'Infections-observed-Coxa Vara', 'Anorexia-investigated-Nausea', 'Anorexia-investigated-Vomiting', 'Fractures, Bone-provide-Postpartum Hemorrhage', 'Cerebral Infarction-associated-Pneumonia', 'Pneumonia-associated-Cerebral Infarction', 'Alzheimer Disease-differentiate-Parkinson Disease', 'Alzheimer Disease-differentiate-Lewy Body Disease', 'Heart Failure-exclude-Dyspnea', 'Pneumococcal Infections-decrease-Death', 'Fecal Incontinence-associated-Diarrhea', 'Diarrhea-associated-Fecal Incontinence', 'Prostatic Neoplasms-reduce-Neoplasms', 'Fecal Incontinence-associated-Edema', 'Edema-associated-Fecal Incontinence', 'Fecal Incontinence-associated-Ischemia', 'Ischemia-associated-Fecal Incontinence', 'Fecal Incontinence-associated-Prostatic Diseases', 'Prostatic Diseases-associated-Fecal Incontinence', 'Muscular Atrophy-associated-Osteoarthritis', 'Osteoarthritis-associated-Muscular Atrophy', 'Muscular Atrophy-play-Osteoarthritis', 'Deglutition Disorders-caused-Ocular Motility Disorders', 'Deglutition Disorders-caused-Esophageal Achalasia', 'Deglutition Disorders-caused-Spasm', 'Deglutition Disorders-caused-Neoplasms', 'Parkinson Disease-cause-Deglutition Disorders', 'Amyotrophic Lateral Sclerosis-cause-Deglutition Disorders', 'Dementia-diagnose-Intellectual Disability', 'Dementia-suffer-Psychoses, Substance-Induced', 'Alzheimer Disease-follow-Death', 'Intellectual Disability-suffer-Psychoses, Substance-Induced', 'Death-identified-Shock, Cardiogenic', 'Death-identified-Myocardial Infarction', 'Hypertension-prevent-Leukoencephalopathies', 'Hypertension-correlated-Leukoencephalopathies', 'Death-related-Pulmonary Fibrosis', 'Fractures, Bone-regarded-Death', 'Pain-improve-Arthritis, Rheumatoid', 'Delirium-include-Aneurysm', 'Delirium-include-Hydrocephalus', 'Fibromuscular Dysplasia-account-Renal Artery Obstruction', 'Kidney Diseases-denied-Atherosclerosis', 'Dementia-speed-Learning Disabilities', 'Infections-treat-Gastrointestinal Diseases', 'Death-consider-Colorectal Neoplasms', 'Pain-include-Communication Disorders', 'Sleep Wake Disorders-treated-Disorders of Excessive Somnolence', 'Sleep Wake Disorders-achieve-Disorders of Excessive Somnolence', 'Bacteremia-consist-Heart Diseases', 'Renal Artery Obstruction-reverse-Kidney Failure, Chronic', 'Bacteremia-consist-Lupus Erythematosus, Systemic', 'Anemia-serve-Death', 'Anemia-contribute-Fatigue', 'Death-contribute-Fatigue', 'Glaucoma-present-Pain', 'Glaucoma-present-Color Vision Defects', 'Atrial Fibrillation-afflict-Cerebral Infarction', 'Arrhythmias, Cardiac-afflict-Cerebral Infarction', 'Critical Illness-result-Renal Insufficiency', 'Diabetes Mellitus-found-Death', 'Wounds and Injuries-increased-Death, Sudden', 'Wounds and Injuries-suffer-Death, Sudden', 'Death-increased-Death, Sudden', 'Death-suffer-Death, Sudden', 'Stroke-associated-Fecal Incontinence', 'Fecal Incontinence-associated-Stroke', 'Optic Neuropathy, Ischemic-treat-Ganglion Cysts', 'Ischemia-reduce-Ganglion Cysts', 'Ganglion Cysts-improve-Optic Neuropathy, Ischemic', 'Pain-use-von Hippel-Lindau Disease', 'Muscular Dystrophy, Emery-Dreifuss-accompanied-Contracture', 'Muscular Dystrophy, Emery-Dreifuss-accompanied-Cardiomyopathy, Dilated', 'Arrhythmias, Cardiac-discussed-Hypertension', 'Ventricular Dysfunction, Left-prevent-Heart Failure', 'Ovarian Diseases-increase-Fractures, Bone', 'Parasitic Diseases-overlap-Schistosomiasis', 'Parasitic Diseases-address-Infections', 'Schistosomiasis-address-Infections', 'Neoplasms-result-Anemia', 'Anemia-treat-Neoplasms', 'Drug Overdose-combine-Liver Diseases', 'Drug Overdose-avoided-Liver Diseases', 'Chemical and Drug Induced Liver Injury-combine-Liver Diseases', 'Chemical and Drug Induced Liver Injury-avoided-Liver Diseases', 'Liver Diseases-used-Blood Platelet Disorders', 'Liver Diseases-used-Gastrointestinal Diseases', 'Liver Diseases-associated-Kidney Diseases', 'Kidney Diseases-associated-Liver Diseases', 'Muscular Dystrophy, Duchenne-place-Diabetes Mellitus', 'Muscular Dystrophy, Duchenne-sustain-Fractures, Bone', 'Diabetes Mellitus-lose-Muscular Dystrophy, Duchenne', 'Diabetes Mellitus-associated-Femoral Neck Fractures', 'Femoral Neck Fractures-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-Muscular Dystrophy, Duchenne', 'Muscular Dystrophy, Duchenne-associated-Diabetes Mellitus', 'Fractures, Bone-observed-Diabetes Mellitus', 'Neurologic Manifestations-classified-Erectile Dysfunction', 'Communicable Diseases-include-Tuberculosis, Hepatic', 'Dementia, Vascular-identified-Leukoencephalopathies', 'Atherosclerosis-lead-Nervous System Diseases', 'Cerebrovascular Disorders-contribute-Dementia, Vascular', 'Cerebrovascular Disorders-suspected-Alzheimer Disease', 'Dementia, Vascular-suspected-Alzheimer Disease', 'Dementia, Vascular-predispose-Alzheimer Disease', 'Aneurysm-shift-Heart Diseases', 'Infertility, Female-fail-Ovarian Diseases', 'Infertility, Female-respond-Ovarian Diseases', 'Neoplasms-silenced-Leukemia', 'Progeria-demonstrate-Cardiovascular Diseases', 'Cardiovascular Diseases-need-Dyslipidemias', 'Hypopituitarism-tested-Wounds and Injuries', 'Dwarfism, Pituitary-tested-Wounds and Injuries', 'Wounds and Injuries-tested-Brain Injuries, Traumatic', 'Arbovirus Infections-cause-Carcinoma, Squamous Cell', 'Acute Kidney Injury-known-Diarrhea', 'Cerebral Infarction-examine-Death', 'Acidosis-associated-Acute Kidney Injury', 'Acute Kidney Injury-associated-Acidosis', 'Acidosis-associated-Sepsis', 'Sepsis-associated-Acidosis', 'Renal Insufficiency-accumulate-Acidosis', 'Acute Kidney Injury-associated-Cholecystolithiasis', 'Cholecystolithiasis-associated-Acute Kidney Injury', 'Gangrene-cause-Pain', 'Cerebral Infarction-account-Stroke', 'Diabetes Mellitus-associate-Stroke', 'Stroke-associate-Diabetes Mellitus', 'Neoplasms-mistaken-Precancerous Conditions', 'Metabolic Syndrome-associate-Stroke', 'Stroke-associate-Metabolic Syndrome', 'Arthritis, Rheumatoid-manifest-Arthritis', 'Arthritis, Rheumatoid-associated-Lung Diseases, Interstitial', 'Lung Diseases, Interstitial-associated-Arthritis, Rheumatoid', 'Carcinoma, Squamous Cell-associated-Papillomavirus Infections', 'Papillomavirus Infections-associated-Carcinoma, Squamous Cell', 'Adenocarcinoma-found-Adenocarcinoma of Lung', 'Coronary Artery Disease-confer-Nervous System Diseases', 'Hypertension-confer-Nervous System Diseases', 'Diabetes Mellitus-confer-Nervous System Diseases', 'Neoplasms-lead-Malnutrition', 'Neurologic Manifestations-undergo-Death', 'Malnutrition-lead-Anorexia', 'Neurologic Manifestations-respond-Heart Arrest', 'Neurologic Manifestations-undergo-Neoplasms', 'Cachexia-suffer-Weight Loss', 'Neurotoxicity Syndromes-recognized-Parkinson Disease, Secondary', 'Chromosome Aberrations-underlie-Myelodysplastic Syndromes', 'Death-delayed-Hip Fractures', 'Status Epilepticus-attributed-Cerebral Infarction', 'Status Epilepticus-attributed-Cerebral Hemorrhage', 'Death, Sudden-show-Coma', 'Coma-overcome-Metabolic Diseases', 'Ventricular Dysfunction-lead-Pulmonary Edema', 'Cerebral Infarction-experience-Pneumonia', 'Deglutition Disorders-induced-Cerebrovascular Disorders', 'Deglutition Disorders-induced-Basal Ganglia Diseases', 'Atherosclerosis-found-Tinnitus', 'Neoplasms-found-Head and Neck Neoplasms', 'Adrenal Insufficiency-defined-Hyperparathyroidism', 'Adrenal Insufficiency-prevent-Hyperparathyroidism', 'Adrenal Insufficiency-related-Colorectal Neoplasms', 'Adrenal Insufficiency-related-Diabetes Mellitus', 'Adrenal Insufficiency-related-Cardiovascular Diseases', 'Adrenal Insufficiency-related-Hypertension', 'Hyperpigmentation-made-Glaucoma', 'Hyperpigmentation-made-Glaucoma, Open-Angle', 'Cardiac Output, Low-fall-Cataract', 'Mouth Diseases-droppe-Stomatitis, Denture', 'Movement Disorders-limited-Osteoarthritis', 'Wounds and Injuries-induce-Movement Disorders', 'Death-change-Cardiovascular Diseases', 'Kidney Failure, Chronic-ascribed-Kidney Diseases', 'Kidney Failure, Chronic-defined-Death', 'Hypercholesterolemia-associated-Renal Insufficiency, Chronic', 'Renal Insufficiency, Chronic-associated-Hypercholesterolemia', 'Diabetes Mellitus-result-Renal Insufficiency, Chronic', 'Diabetes Mellitus-result-Kidney Failure, Chronic', 'Death-identify-Kidney Failure, Chronic', 'Ischemia-irrigated-Hypertension', 'Hypertension-sever-Basal Ganglia Diseases', 'Alzheimer Disease-show-Dystonia', 'Diabetes Mellitus-combine-Renal Insufficiency', 'Chronic Disease-combine-Renal Insufficiency', 'Parkinson Disease, Secondary-tend-Tremor', 'Xerostomia-include-Nervous System Diseases', 'Xerostomia-include-Diabetes Mellitus', 'Hypertension-include-Xerostomia', 'Muscle Rigidity-do-Tremor', 'Arthritis-associated-Parkinsonian Disorders', 'Parkinsonian Disorders-associated-Arthritis', 'Heart Diseases-become-Heart Failure', 'Sleep Wake Disorders-categorize-Hypertension', 'Sleep Wake Disorders-distinguish-Hypertension', 'Pain-remove-Joint Dislocations', 'Pain-remove-Fractures, Bone', 'Hypothalamic Neoplasms-associated-Seizures', 'Seizures-associated-Hypothalamic Neoplasms', 'Hypothalamic Neoplasms-attenuate-Seizures', 'Colorectal Neoplasms-found-Neoplasms', 'Muscular Dystrophy, Emery-Dreifuss-seen-Progeria', 'HIV Infections-include-Onychomycosis', 'Sarcopenia-judge-Muscular Diseases', 'Neuroacanthocytosis-show-Hypotension', 'Thromboembolism-result-Death', 'Diabetes Mellitus-affect-Neoplasms', 'Diabetes Mellitus-affect-Breast Neoplasms', 'Hypertension-increase-Fatigue', 'Leukemia-compare-Death', 'Inflammation-elevated-Alzheimer Disease', 'Anemia, Iron-Deficiency-ran-Neoplasms', 'Chronic Pain-include-Sleep Wake Disorders', 'Endocarditis-complicated-Hemiplegia', 'Venous Thromboembolism-present-Renal Insufficiency', 'Cough-Stress-Urinary Incontinence, Stress', 'Urinary Incontinence-Stress-Urinary Incontinence, Stress', 'Cough-Stress-Urinary Incontinence', 'Hypotension-control-Diabetes Mellitus', 'Aneurysm-defined-Arterial Occlusive Diseases', 'Death-required-Status Epilepticus', 'Fractures, Bone-influence-Osteoporosis', 'Carcinoma, Merkel Cell-rank-Neoplasms', 'Osteoarthritis-characterised-Arthralgia', 'Drug-Related Side Effects and Adverse Reactions-result-Neoplasms', 'Leg Ulcer-treated-Ulcer', 'Neoplasms-result-Ischemia', 'Neoplasms-treat-Ischemia', 'Hypothyroidism-cause-Constipation', 'Constipation-cause-Hypothyroidism', 'Constipation-treated-Dehydration', 'Nocturia-questioned-Sleep Wake Disorders', 'Fractures, Bone-use-Osteoporosis', 'Lupus Erythematosus, Systemic-manifest-Cardiovascular Diseases', 'Atherosclerosis-involved-Lupus Erythematosus, Systemic', 'Pain-augment-Fractures, Bone', 'Aneurysm-report-Erectile Dysfunction', 'Erectile Dysfunction-report-Atherosclerosis', 'Hyperlipidemias-affected-Diabetes Mellitus', 'Cataract-lead-Death', 'Neurotoxicity Syndromes-reduce-Neurodegenerative Diseases', 'Wasting Syndrome-suffer-Sarcopenia', 'HIV Infections-suffer-Sarcopenia', 'Neoplasms-suffer-Sarcopenia', 'Hypercholesterolemia-associated-Alzheimer Disease', 'Alzheimer Disease-associated-Hypercholesterolemia', 'Hypotension-assess-Dyspnea', 'Coronary Artery Disease-continue-Death', 'Death-given-Myocardial Infarction', 'AIDS Dementia Complex-associated-HIV Infections', 'HIV Infections-associated-AIDS Dementia Complex', 'Death-appear-Mitochondrial Diseases', 'Carcinoma, Squamous Cell-reclassified-Carcinoma, Adenosquamous', 'Renal Artery Obstruction-performed-Hypertension', 'Coronary Artery Disease-associated-Renal Artery Obstruction', 'Renal Artery Obstruction-associated-Coronary Artery Disease', 'Hypokalemia-associated-Renal Artery Obstruction', 'Renal Artery Obstruction-associated-Hypokalemia', 'Cardiovascular Diseases-mediated-Seizures', 'Pneumocephalus-result-Wounds and Injuries', 'Pneumocephalus-result-Infections', 'Pneumocephalus-associated-Osteopetrosis', 'Osteopetrosis-associated-Pneumocephalus', 'Hip Fractures-registered-Wounds and Injuries', 'Precursor Cell Lymphoblastic Leukemia-Lymphoma-represent-Neoplasms', 'Death-include-Vision Disorders', 'Plaque, Amyloid-obtained-Alzheimer Disease', 'Malaria-retain-Infections', 'Heart Failure-diagnosed-Myocardial Infarction', 'Neoplasms-disseminate-Bone Marrow Neoplasms', 'Erectile Dysfunction-seen-Priapism', 'Impotence, Vasculogenic-result-Priapism', 'Dyskeratosis Congenita-define-Neoplasms', 'Aging, Premature-characterized-Osteoporosis', 'Aging, Premature-characterized-Cataract', 'Aging, Premature-characterized-Diabetes Mellitus', 'Aging, Premature-characterized-Arteriosclerosis', 'Heart Failure, Diastolic-address-Hypertension', 'Neoplasms-receive-Pain', 'Neoplasms-help-Pain', 'Delirium-pose-Neoplasms', 'Delirium-impede-Neoplasms', 'Delirium-recognize-Dementia', 'Infections-follow-Skin Diseases', 'Mycoses-follow-Skin Diseases', 'Skin Diseases-cause-Diabetes Mellitus', 'Cardiomyopathies-show-Mitral Valve Insufficiency', 'Leptospirosis-vary-Infections', 'Acute Kidney Injury-suspect-Leptospirosis', 'Jaundice-suspect-Leptospirosis', 'Oliguria-increase-Death', 'Oliguria-increase-Leptospirosis', 'Leptospirosis-present-Renal Insufficiency', 'Renal Insufficiency-present-Death', 'Anuria-increase-Death', 'Anuria-increase-Leptospirosis', 'Death-conferred-Renal Insufficiency, Chronic', 'Death-conferred-Anemia', 'Death-conferred-Heart Failure', 'Death-censor-Kidney Failure, Chronic', 'Alzheimer Disease-favor-Neurodegenerative Diseases', 'Edema-subside-Erythema', 'Edema-subside-Pruritus', 'Venous Thromboembolism-conducted-Wounds and Injuries', 'Heart Valve Diseases-based-Calcinosis', 'Paralysis-follow-Urinary Incontinence', 'Diabetes Mellitus-interact-Aneurysm', 'Diabetes Mellitus-interact-Alzheimer Disease', 'Menorrhagia-experience-Amenorrhea', 'Hemorrhage-experience-Amenorrhea', 'Urinary Incontinence-cause-Infections', 'Urinary Incontinence-cause-Drug Hypersensitivity', 'Urinary Incontinence-cause-Neoplasms', 'Infections-cause-Drug Hypersensitivity', 'Infections-cause-Neoplasms', 'Drug Hypersensitivity-cause-Neoplasms', 'Pain-diagnose-Osteoarthritis', 'Diabetes Mellitus, Type 2-result-Insulin Resistance', 'Insulin Resistance-induce-Diabetes Mellitus, Type 2', 'Metabolic Diseases-undergo-Neoplasms', 'Pain-persist-Exanthema', 'Pain-termed-Neuralgia', 'Exanthema-termed-Neuralgia', 'Postoperative Cognitive Complications-seem-Pain, Postoperative', 'Delirium-seem-Pain, Postoperative', 'Atrial Fibrillation-found-Death', 'Immunologic Deficiency Syndromes-associated-Multiple Sclerosis', 'Multiple Sclerosis-associated-Immunologic Deficiency Syndromes', 'Immunologic Deficiency Syndromes-associated-Arthritis, Rheumatoid', 'Arthritis, Rheumatoid-associated-Immunologic Deficiency Syndromes', 'Myocardial Infarction-prevent-Ischemia', 'Epilepsy-represent-Seizures', 'Spinal Stenosis-correlate-Muscle Weakness', 'Atrial Fibrillation-associate-Cardiovascular Diseases', 'Cardiovascular Diseases-associate-Atrial Fibrillation', 'Atrial Fibrillation-associate-Coronary Artery Disease', 'Coronary Artery Disease-associate-Atrial Fibrillation', 'Atrial Fibrillation-associate-Hypertension', 'Hypertension-associate-Atrial Fibrillation', 'Atrial Fibrillation-induce-Heart Diseases', 'Chronobiology Disorders-associate-Cardiovascular Diseases', 'Cardiovascular Diseases-associate-Chronobiology Disorders', 'Nerve Degeneration-prevent-Neurodegenerative Diseases', 'Chronobiology Disorders-associate-Coronary Artery Disease', 'Coronary Artery Disease-associate-Chronobiology Disorders', 'Chronobiology Disorders-associate-Hypertension', 'Hypertension-associate-Chronobiology Disorders', 'Erectile Dysfunction-associated-Aneurysm', 'Aneurysm-associated-Erectile Dysfunction', 'Fibrosis-include-Erectile Dysfunction', 'Diabetes Mellitus-seen-AIDS Dementia Complex', 'Osteoporosis-stem-Fractures, Bone', 'Osteoporosis-noting-Fractures, Bone', 'Fractures, Bone-stand-Osteoporosis', 'Osteoporosis-stand-Fractures, Bone', 'Osteoporosis-become-Hip Fractures', 'Hypertension-influenced-Diabetes Mellitus', 'Hip Fractures-stand-Osteoporosis', 'Prostatic Neoplasms-associated-Pain', 'Pain-associated-Prostatic Neoplasms', 'Muscular Diseases-take-Rhabdomyolysis', 'Muscular Diseases-lead-Acute Kidney Injury', 'Rhabdomyolysis-lead-Acute Kidney Injury', 'Memory Disorders-report-Dementia', 'Meningeal Neoplasms-increase-Neoplasms', 'Neurodegenerative Diseases-remain-Amyotrophic Lateral Sclerosis', 'Histiocytoma, Malignant Fibrous-referred-Aging, Premature', 'Muscle Weakness-control-Fatigue', 'Fatigue-related-Nerve Degeneration', 'Death-related-Communicable Diseases', 'Hemolytic-Uremic Syndrome-stay-Death', 'Myocardial Infarction-constitute-Death', 'Myocardial Infarction-constitute-Kidney Failure, Chronic', 'Dementia-double-Cerebrovascular Disorders', 'Dementia-linked-Cerebrovascular Disorders', 'Osteoarthritis-identify-Pain', 'Hip Fractures-considered-Pulmonary Embolism', 'Venous Thromboembolism-consist-Venous Thrombosis', 'Venous Thromboembolism-consist-Pulmonary Embolism', 'Venous Thromboembolism-consist-Death', 'Venous Thrombosis-associated-Death', 'Death-associated-Venous Thrombosis', 'Malnutrition-measured-Death', 'Malnutrition-measured-Infections', 'Colorectal Neoplasms-decrease-Death', 'Lung Neoplasms-show-Death', 'Sensation Disorders-exhibit-Pain', 'Sensation Disorders-exhibit-Sciatic Neuropathy', 'Pain-exhibit-Sciatic Neuropathy', 'Prostatic Hyperplasia-characterized-Urinary Bladder Diseases', 'Prostatic Hyperplasia-characterized-Urinary Incontinence', 'Prostatic Hyperplasia-caused-Prostatitis', 'Prostatic Hyperplasia-become-Neurologic Manifestations', 'Urinary Bladder, Overactive-characterized-Urinary Incontinence', 'Urinary Bladder, Overactive-characterized-Nocturia', 'Xerostomia-result-Pain', 'Pain-result-Dyspareunia', 'Neoplasms-paralyze-Paralysis', 'Hypogonadism-address-Prostatic Diseases', 'Paralysis-cause-Laryngeal Neoplasms', 'Paralysis-cause-Neoplasms', 'Melanoma-display-Pigmentation Disorders', 'Tetany-include-Diabetes Mellitus', 'Nocturia-diminished-Infections', 'Dementia, Vascular-confirm-Dementia', 'Hypertension-prevent-Dementia, Vascular', 'Hypertension-prevent-Alzheimer Disease', 'Alzheimer Disease-predominate-Dementia, Vascular', 'Dementia, Vascular-represent-Stroke', 'Aphasia-result-Stroke', 'Dementia, Vascular-demonstrated-Memory Disorders', 'Dementia, Vascular-demonstrated-Cerebrovascular Disorders', 'Dementia-exist-Dementia, Vascular', 'Dementia-demonstrated-Cerebrovascular Disorders', 'Cerebrovascular Disorders-result-Dementia, Vascular', 'Memory Disorders-demonstrated-Cerebrovascular Disorders', 'Cerebrovascular Disorders-demonstrated-Stroke', 'Alzheimer Disease-worsened-Stroke', 'Fractures, Bone-carry-Hip Fractures', 'Hip Fractures-carry-Spinal Fractures', 'Erectile Dysfunction-correlated-Diabetes Mellitus', 'Prostatic Neoplasms-consider-Death', 'Neck Pain-bear-Neoplasms', 'Headache-bear-Multiple Myeloma', 'Headache-bear-Neoplasms', 'Dementia, Vascular-assigned-Dementia', 'Hyperparathyroidism, Primary-associated-Death', 'Death-associated-Hyperparathyroidism, Primary', 'Death-associated-Hyperparathyroidism, Secondary', 'Hyperparathyroidism, Secondary-associated-Death', 'Hyperemia-occure-Ischemia', 'Diabetes Mellitus-represent-Death', 'Pain-evaluated-Osteoarthritis', 'Diabetes Mellitus-suffer-Cataract', 'Cardiomyopathies-develop-Heart Failure', 'Lupus Erythematosus, Systemic-occur-Arthritis', 'Lupus Erythematosus, Systemic-occur-Exanthema', 'Lupus Erythematosus, Systemic-occur-Kidney Diseases', 'Lupus Erythematosus, Systemic-characterized-Serositis', 'Lupus Erythematosus, Systemic-characterized-Lung Diseases', 'Lupus Erythematosus, Systemic-characterized-Exanthema', 'Lupus Erythematosus, Systemic-characterized-Vasculitis, Leukocytoclastic, Cutaneous', 'Death-occur-Lupus Erythematosus, Systemic', 'Lupus Erythematosus, Systemic-characterized-Raynaud Disease', 'Lupus Erythematosus, Systemic-characterized-Lymphatic Diseases', 'Lupus Erythematosus, Systemic-characterized-Nephrotic Syndrome', 'Lupus Erythematosus, Systemic-characterized-Nephritis', 'Ventricular Remodeling-enhanced-Vascular System Injuries', 'Ventricular Remodeling-enhanced-Heart Failure', 'Ventricular Dysfunction, Left-result-Cardiac Output, Low', 'Metabolic Syndrome-develop-Obesity', 'Infections-become-HIV Infections', 'Arthritis-suffer-Cardiac Output, Low', 'Infections-become-Acquired Immunodeficiency Syndrome', 'Infections-become-Neoplasms', 'Joint Diseases-afford-Pain', 'Diabetes Mellitus, Type 2-become-Death', 'Entropion-include-Waardenburg Syndrome', 'Migraine Disorders-associated-Headache', 'Headache-associated-Migraine Disorders', 'Migraine with Aura-occur-Headache', 'Migraine with Aura-termed-Migraine Disorders', 'Headache-termed-Migraine Disorders', 'Nephritis, Interstitial-observed-Hypertension', 'Lupus Erythematosus, Systemic-represent-IgA Vasculitis', 'Lupus Erythematosus, Systemic-represent-Kidney Diseases', 'Lupus Erythematosus, Systemic-represent-Multiple Myeloma', 'Diabetes Mellitus-represent-Proteinuria', 'Diabetes Mellitus-represent-Diabetic Nephropathies', 'Diabetes Mellitus-represent-Vasculitis', 'Proteinuria-found-Diabetes Mellitus', 'Proteinuria-represent-Diabetic Nephropathies', 'Proteinuria-represent-Vasculitis', 'Diabetes Mellitus-found-Diabetic Nephropathies', 'Diabetes Mellitus-found-Vasculitis', 'Neoplasms-emerging-Lung Neoplasms', 'Hypertension-associated-Stroke, Lacunar', 'Stroke, Lacunar-associated-Hypertension', 'Hypotension-operate-Osteoporotic Fractures', 'Fractures, Bone-exacerbated-Osteoporosis', 'Fractures, Bone-operate-Sleep Initiation and Maintenance Disorders', 'Fractures, Bone-hold-Sleep Initiation and Maintenance Disorders', 'Osteoporosis-contribute-Death', 'Leukoencephalopathies-tracked-Dementia', 'Parkinson Disease-represent-Alzheimer Disease', 'Alzheimer Disease-based-Dementia', 'Alzheimer Disease-affected-Dementia', 'Myelodysplastic Syndromes-remain-Death', 'Pneumonia-include-Arbovirus Infections', 'Pneumonia-include-Multiple Organ Failure', 'Pneumonia-include-Lung Diseases, Interstitial', 'Respiratory Tract Infections-treat-Pneumonia', 'Lung Diseases, Interstitial-include-Multiple Organ Failure', 'Osteoporosis-recognized-Chronic Kidney Disease-Mineral and Bone Disorder', 'Osteoporosis-associated-Chronic Kidney Disease-Mineral and Bone Disorder', 'Chronic Kidney Disease-Mineral and Bone Disorder-associated-Osteoporosis', 'Osteoporosis-begin-Fractures, Bone', 'Chronic Kidney Disease-Mineral and Bone Disorder-begin-Fractures, Bone', 'Death-involve-Chronic Disease', 'Death-involve-Kidney Diseases', 'Diabetes Mellitus-test-Kidney Diseases', 'Kidney Failure, Chronic-aggravated-Diabetes Mellitus', 'Kidney Failure, Chronic-aggravated-Hypertension', 'Kidney Failure, Chronic-associated-Autoimmune Diseases', 'Autoimmune Diseases-associated-Kidney Failure, Chronic', 'Charles Bonnet Syndrome-characterized-Hallucinations', 'Hallucinations-associated-Delirium', 'Delirium-associated-Hallucinations', 'Osteoarthritis, Spine-associated-Back Pain', 'Back Pain-associated-Osteoarthritis, Spine', 'Osteoarthritis-consist-Joint Diseases', 'Osteoarthritis-occur-Pain', 'Aneurysm-associated-Rupture', 'Rupture-associated-Aneurysm', 'Dementia-occur-Diabetes Mellitus', 'Dementia-occur-Hypertension', 'Dementia-occur-Heart Diseases', 'Dementia, Vascular-occur-Diabetes Mellitus', 'Dementia, Vascular-occur-Hypertension', 'Dementia, Vascular-occur-Heart Diseases', 'Diabetes Mellitus-occur-Hypertension', 'Diabetes Mellitus-occur-Heart Diseases', 'Heart Failure-cause-Ventricular Fibrillation', 'Sick Sinus Syndrome-play-Psychomotor Disorders', 'Atrial Fibrillation-play-Psychomotor Disorders', 'Bradycardia-play-Psychomotor Disorders', 'Thrombosis-lead-Arteriovenous Fistula', 'Parkinson Disease-alleviate-Tremor', 'Parkinson Disease-shown-Dyskinesia, Drug-Induced', 'Psychoses, Substance-Induced-alleviate-Tremor', 'Psychoses, Substance-Induced-shown-Dyskinesia, Drug-Induced', 'Neuronal Ceroid-Lipofuscinoses-lead-Leber Congenital Amaurosis', 'Neuronal Ceroid-Lipofuscinoses-lead-Neurodegenerative Diseases', 'Neuronal Ceroid-Lipofuscinoses-lead-Death', 'Ovarian Diseases-treated-Lupus Nephritis', 'Aphasia-include-Stroke', 'Alzheimer Disease-mediate-Thoracic Outlet Syndrome', 'Cerebrovascular Disorders-mediate-Thoracic Outlet Syndrome', 'Cerebrovascular Disorders-associated-Thoracic Outlet Syndrome', 'Thoracic Outlet Syndrome-associated-Cerebrovascular Disorders', 'Kidney Diseases-become-Hypertension', 'Neuronal Ceroid-Lipofuscinoses-comprise-Brain Diseases', 'Hypoxia-recognized-Bone Neoplasms', 'Chronic Disease-followed-Musculoskeletal Diseases', 'Craniofacial Abnormalities-contribute-Sleep Apnea, Obstructive', 'Obesity-contribute-Sleep Apnea, Obstructive', 'Hypertrophy-contribute-Sleep Apnea, Obstructive', 'Nervous System Diseases-associated-Parkinsonian Disorders', 'Parkinsonian Disorders-associated-Nervous System Diseases', 'Hypertension-less-Hyperglycemia', 'Dyslipidemias-less-Hyperglycemia', 'Hyperglycemia-less-Cardiovascular Diseases', 'Hyperglycemia-less-Kidney Diseases', 'Hyperglycemia-less-Diabetes Mellitus', 'Thyroid Cancer, Papillary-predict-Neoplasms', 'Thyroid Cancer, Papillary-predict-Death', 'Heart Failure-become-Atrial Fibrillation', 'Cardiovascular Diseases-become-Atrial Fibrillation', 'Atrial Fibrillation-worsen-Heart Failure', 'Atrial Fibrillation-compromise-Heart Failure, Systolic', 'Heart Failure-compromise-Heart Failure, Systolic', 'Heart Failure-provide-Atrial Fibrillation', 'Heart Failure-provide-Death', 'Heart Failure-worsen-Atrial Fibrillation', 'Cardiomyopathies-worsen-Atrial Fibrillation', 'Adenocarcinoma-account-Neoplasms', 'Protein S Deficiency-considered-Retinal Vein Occlusion', 'Learning Disabilities-do-Colorectal Neoplasms', 'Death-relate-Learning Disabilities', 'Death-relate-Colorectal Neoplasms', 'Learning Disabilities-relate-Colorectal Neoplasms', 'Neoplasms-bring-Learning Disabilities', 'Gilbert Disease-appear-Gallstones', 'Heredodegenerative Disorders, Nervous System-include-Neurodegenerative Diseases', 'Infertility, Female-include-Neurodegenerative Diseases', 'Infections-include-Neurodegenerative Diseases', 'Erectile Dysfunction-considered-Diabetes Mellitus', 'Erectile Dysfunction-include-Hypogonadism', 'Erectile Dysfunction-considered-Hypogonadism', 'Urinary Bladder Diseases-show-Sensation Disorders', 'Urinary Bladder Diseases-show-Ulcer', 'Urinary Bladder Diseases-show-Urinary Tract Infections', 'Muscular Dystrophy, Duchenne-indicate-Osteoporotic Fractures', 'Muscular Dystrophy, Duchenne-reveal-Bone Diseases, Metabolic', 'Bone Diseases, Metabolic-reveal-Osteoporosis', 'Alzheimer Disease-arise-Neurodegenerative Diseases', 'Myelodysplastic Syndromes-characterized-Adrenal Insufficiency', 'Myelodysplastic Syndromes-lead-Leukemia, Myeloid, Acute', 'Magnesium Deficiency-include-Hypertension', 'Adrenal Insufficiency-associated-Hematologic Diseases', 'Hematologic Diseases-associated-Adrenal Insufficiency', 'Magnesium Deficiency-include-Heart Failure', 'Adrenal Insufficiency-characterized-Leukemia, Myeloid, Acute', 'Hematologic Diseases-lead-Leukemia, Myeloid, Acute', 'Magnesium Deficiency-include-Arrhythmias, Cardiac', 'Magnesium Deficiency-include-Myocardial Infarction', 'Magnesium Deficiency-include-Diabetes Mellitus', 'Death, Sudden-include-Cardiomyopathies', 'Stroke-include-Cardiomyopathies', 'Hyperhomocysteinemia-established-Cardiovascular Diseases', 'Ventricular Dysfunction, Left-correlate-Cardiomyopathies', 'Kidney Failure, Chronic-caused-Genetic Diseases, Inborn', 'Kidney Failure, Chronic-caused-Diabetic Nephropathies', 'Infections-experience-Pain', 'Infections-experience-Diarrhea', 'Infections-experience-Abdominal Pain', 'Cryptosporidiosis-considered-Infections', 'Weight Loss-attributed-Neoplasms', 'Infections-demonstrate-Eosinophilia', 'Obesity-show-Movement Disorders', 'Fragile X Syndrome-develop-Primary Ovarian Insufficiency', 'Inflammatory Bowel Diseases-associated-Osteoporosis', 'Osteoporosis-associated-Inflammatory Bowel Diseases', 'Femoral Fractures-treated-Hip Fractures', 'Hip Fractures-compared-Fractures, Bone', 'Drug-Related Side Effects and Adverse Reactions-represent-Urinary Bladder Neoplasms', 'Drug-Related Side Effects and Adverse Reactions-include-Fatigue', 'Muscle Spasticity-improve-Spasm', 'Onychomycosis-divided-HIV Infections', 'Lymphoma-find-Neutropenia', 'Neoplasms-find-Neutropenia', 'Anemia-increase-Drug-Related Side Effects and Adverse Reactions', 'Diabetes Mellitus-involve-Infections', 'Parkinsonian Disorders-measured-Hypokinesia', 'Parkinsonian Disorders-measured-Gait Disorders, Neurologic', 'Parkinsonian Disorders-measured-Muscle Rigidity', 'Parkinsonian Disorders-measured-Tremor', 'Parkinson Disease, Secondary-excluded-Parkinson Disease', 'Parkinson Disease, Secondary-attenuated-Stroke', 'Infarction-related-Ischemia', 'Gastrointestinal Diseases-associated-Pancytopenia', 'Pancytopenia-associated-Gastrointestinal Diseases', 'Hepatic Veno-Occlusive Disease-result-Death', 'Hepatic Veno-Occlusive Disease-result-Liver Failure', 'Hypertension-remain-Dementia, Vascular', 'Cerebrovascular Disorders-including-Atherosclerosis', 'Coronary Artery Disease-including-Atherosclerosis', 'Kidney Diseases-influence-Renal Insufficiency, Chronic', 'Renal Insufficiency, Chronic-estimated-Death', 'Neoplasm Metastasis-mimic-Meningeal Neoplasms', 'Venous Thromboembolism-manifest-Venous Thrombosis', 'Venous Thromboembolism-manifest-Pulmonary Embolism', 'Acute Kidney Injury-followed-Death', 'Death-associated-Oliguria', 'Oliguria-associated-Death', 'Death-associated-Hematologic Diseases', 'Hematologic Diseases-associated-Death', 'Osteoarthritis-account-Joint Diseases', 'Pain Insensitivity, Congenital-treat-Breakthrough Pain', 'Tricuspid Valve Insufficiency-found-Atrial Fibrillation', 'Basal Ganglia Cerebrovascular Disease-seen-Diabetes Mellitus', 'Basal Ganglia Cerebrovascular Disease-seen-Uremia', 'Sotos Syndrome-lead-Neoplasms', 'Mastocytosis, Systemic-compromise-Giant Cell Arteritis', 'Mastocytosis, Systemic-compromise-Hypertension', 'Mastocytosis, Systemic-compromise-Diabetes Mellitus', 'Postpartum Hemorrhage-result-Optic Neuropathy, Ischemic', 'Brain Injuries, Traumatic-result-Optic Neuropathy, Ischemic', 'Hypovolemia-diagnosed-Optic Neuropathy, Ischemic', 'Vision Disorders-screened-Optic Neuropathy, Ischemic', 'Optic Atrophy-precipitate-Postpartum Hemorrhage', 'Postpartum Hemorrhage-trigger-Optic Neuropathy, Ischemic', 'Endometrial Hyperplasia-suggest-Neoplasms', 'Thrombophilia-associated-Sepsis', 'Sepsis-associated-Thrombophilia', 'Osteoporosis-characterised-Bone Neoplasms', 'Thrombophilia-associated-Inflammation', 'Inflammation-associated-Thrombophilia', 'Thrombophilia-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-Thrombophilia', 'Thrombophilia-associated-Neoplasms', 'Neoplasms-associated-Thrombophilia', 'Thrombophilia-result-Disseminated Intravascular Coagulation', 'Thrombophilia-result-Venous Thrombosis', 'Thrombophilia-result-Cardiovascular Diseases', 'Thrombophilia-result-Multiple Organ Failure', 'Cardiomyopathy, Hypertrophic-associated-Arrhythmias, Cardiac', 'Arrhythmias, Cardiac-associated-Cardiomyopathy, Hypertrophic', 'Myotonic Disorders-show-Muscular Diseases', 'Rhinitis-decline-Drug Hypersensitivity', 'Myelodysplastic Syndromes-grouped-Bone Marrow Failure Disorders', 'Anemia, Aplastic-grouped-Bone Marrow Failure Disorders', 'Myelodysplastic Syndromes-differ-Anemia, Aplastic', 'Myelodysplastic Syndromes-terminate-Leukemia, Myeloid, Acute', "Xerostomia-suffer-Sjogren's Syndrome", 'Parkinsonian Disorders-rated-Parkinson Disease', 'Parkinson Disease-result-Parkinsonian Disorders', 'Parkinson Disease-divided-Muscle Rigidity', 'Parkinson Disease-divided-Tremor', 'Parkinsonian Disorders-associated-Stroke', 'Stroke-associated-Parkinsonian Disorders', 'Neurodegenerative Diseases-refer-Alzheimer Disease', 'Osteoarthritis-refer-Alzheimer Disease', 'Pulmonary Disease, Chronic Obstructive-considered-Cough', 'Pulmonary Disease, Chronic Obstructive-considered-Dyspnea', 'Vision Disorders-implicated-Fractures, Bone', 'Bone Neoplasms-define-Muscular Dystrophy, Duchenne', 'Prostatic Neoplasms-induced-Heart Arrest', 'Venous Thromboembolism-outweigh-Hemorrhage', 'Urinary Incontinence-manifest-Urinary Incontinence, Stress', 'Urinary Incontinence, Stress-understood-Obesity', 'Neoplasms-confront-Myelodysplastic Syndromes', 'Atherosclerosis-reduce-Stroke', 'Eunuchism-characterized-Sexual Dysfunction, Physiological', 'Eunuchism-associated-Sexual Dysfunction, Physiological', 'Sexual Dysfunction, Physiological-associated-Eunuchism', 'Postpartum Hemorrhage-compared-Hemiplegia', 'Femoral Neck Fractures-treat-Hemiplegia', 'Sensation Disorders-prevent-Delirium', 'Tuberculosis-succumb-Communicable Diseases', 'Communicable Diseases-prevent-Infections', 'Fractures, Bone-increase-Coronary Artery Disease', 'Cachexia-characterized-Necrosis', 'Metabolic Diseases-observed-Cachexia', 'Contracture-restored-Fractures, Bone', 'Urinary Incontinence, Stress-associated-Pulmonary Disease, Chronic Obstructive', 'Pulmonary Disease, Chronic Obstructive-associated-Urinary Incontinence, Stress', 'Urinary Incontinence, Stress-associated-Arthritis', 'Arthritis-associated-Urinary Incontinence, Stress', 'Acute Kidney Injury-appear-Diabetes Mellitus', 'Acute Kidney Injury-appear-Hypertension', 'Bernard-Soulier Syndrome-suffer-Corneal Diseases', 'Mitochondrial Diseases-ensue-Drug-Related Side Effects and Adverse Reactions', 'Immunologic Deficiency Syndromes-potentiated-HIV Infections', 'Immunologic Deficiency Syndromes-potentiated-Coinfection', 'Osteoporosis-result-Inflammation', 'Adenomatous Polyposis Coli-associated-Infections', 'Infections-associated-Adenomatous Polyposis Coli', 'Infections-considered-End Stage Liver Disease', 'Pseudomonas Infections-associated-Cross Infection', 'Cross Infection-associated-Pseudomonas Infections', 'Intracranial Arterial Diseases-cause-Deglutition Disorders', 'Parasomnias-examine-Bruxism', 'Parasomnias-examine-Nocturnal Enuresis', 'Parasomnias-associated-Neurobehavioral Manifestations', 'Neurobehavioral Manifestations-associated-Parasomnias', 'Fractures, Bone-associated-Osteolysis', 'Osteolysis-associated-Fractures, Bone', 'Respiratory Tract Diseases-cause-Amnesia', 'Heart Valve Diseases-warrant-Endocarditis', 'Diabetes Mellitus-explain-Bone Diseases, Metabolic', 'Atrial Fibrillation-examined-Heart Diseases', 'Multiple Sclerosis-set-Death', 'Neurocysticercosis-present-Nervous System Diseases', 'Neurocysticercosis-differentiate-Tuberculosis', 'Myocardial Infarction-caused-Atherosclerosis', 'Coronary Artery Disease-account-Atherosclerosis', 'Stroke-account-Atherosclerosis', 'Atherosclerosis-account-Cardiovascular Diseases', 'Fractures, Bone-appear-Muscular Dystrophy, Duchenne', 'Hemolysis-associated-Inflammation', 'Inflammation-associated-Hemolysis', 'Hemolysis-turn-Inflammation', 'Diabetes Mellitus, Type 2-associated-Atherosclerosis', 'Atherosclerosis-associated-Diabetes Mellitus, Type 2', 'Neoplasms-differ-Death', 'Atherosclerosis-increase-Coronary Artery Disease', 'Cerebrovascular Disorders-increase-Diabetes Mellitus', 'Hypotension-affected-Hypotension, Orthostatic', 'Hypotension-affected-Heart Failure', 'Neoplasms-keep-Fatigue', 'Neoplasms-keep-Pain', 'Fatigue-tested-Neoplasms', 'Pain-experience-Neoplasms', 'Death-reduce-Hypoxia', 'Coronary Artery Disease-reduce-Hypoxia', 'Anemia-involve-Fatigue', 'Hyperglycemia-diagnose-Diabetes Mellitus', 'Hypertriglyceridemia-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-Hypertriglyceridemia', 'Hyperhomocysteinemia-found-Aneurysm', 'Neutropenia-treat-Fever', 'Respiratory Insufficiency-related-Pulmonary Disease, Chronic Obstructive', 'Leukoencephalopathies-reflect-Ischemic Attack, Transient', 'Leukoencephalopathies-reflect-Aneurysm', 'Ischemic Attack, Transient-reflect-Aneurysm', 'Inflammation-assess-Drug Hypersensitivity', 'Fibrosis-undergo-Agnosia', 'Hypertension-undergo-Agnosia', 'Neoplasms-arise-Heart Arrest', 'Heart Arrest-trigger-Werner Syndrome', 'Diarrhea-progress-Fever', 'Arthritis, Rheumatoid-known-Osteoarthritis', 'Arthritis, Rheumatoid-share-Osteoarthritis', 'Cerebral Infarction-result-Thrombosis', 'Thrombosis-result-Atrial Fibrillation', 'Cardiovascular Diseases-identified-Erectile Dysfunction', 'Diabetes Mellitus-identified-Erectile Dysfunction', 'Sarcoma, Kaposi-associated-Death', 'Death-associated-Sarcoma, Kaposi', 'Sarcoma, Kaposi-associated-Uterine Cervical Neoplasms', 'Uterine Cervical Neoplasms-associated-Sarcoma, Kaposi', 'Death-associated-Uterine Cervical Neoplasms', 'Uterine Cervical Neoplasms-associated-Death', 'Corneal Diseases-lead-Vision, Low', 'Hypothalamic Neoplasms-attenuated-Seizures', 'Neoplasms-treat-Melanoma', 'Thromboembolism-worsen-Heart Failure', 'Coronary Artery Disease-followed-Stroke', 'Stroke-followed-Thromboembolism', 'Coronary Artery Disease-followed-Thromboembolism', 'Neoplasms-followed-Thromboembolism', 'Stiff-Person Syndrome-defined-Kyphosis', 'Stiff-Person Syndrome-defined-Flatfoot', 'Stiff-Person Syndrome-defined-Lordosis', 'Urinary Incontinence, Stress-associated-Cough', 'Cough-associated-Urinary Incontinence, Stress', 'Urinary Incontinence, Stress-reduce-Urinary Incontinence', 'Urinary Incontinence, Stress-Stress-Cough', 'Dementia-affect-Aneurysm', 'Nerve Degeneration-follow-Brain Ischemia', 'Nerve Degeneration-linked-Brain Ischemia', 'Irritable Bowel Syndrome-reported-Diarrhea', 'Constipation-reported-Diarrhea', 'Irritable Bowel Syndrome-discontinue-Diarrhea', 'Neurotoxicity Syndromes-underlie-Ischemia', 'Extranodal Extension-found-Neurodegenerative Diseases', 'Hypertrophy-underlie-Cardiomyopathies', 'Hypertrophy-compromise-Hypertension', 'Hypertrophy-underlie-Coronary Artery Disease', 'Death-ascribed-Diabetes Mellitus', 'Death-ascribed-Stroke', 'Heart Arrest-include-Diabetes Mellitus', 'Heart Arrest-followed-Neoplasms', 'Stroke-followed-Neoplasms', 'Peripheral Nervous System Diseases-defined-Paraplegia', 'Paraplegia-defined-Foot Ulcer', 'Stroke-affect-Neoplasms', 'Stroke-affect-Heart Diseases', 'Atrial Fibrillation-prevent-Thrombosis', 'Pain-place-Wounds and Injuries', 'Pain-occur-Wounds and Injuries', 'Hyperalgesia-occur-Wounds and Injuries', 'Constriction, Pathologic-demonstrate-Weight Loss', 'Hemorrhage-remain-Myocardial Infarction', 'Neoplasms-give-Genetic Diseases, Inborn', 'Heart Failure-treat-Hypotension', 'Keratoacanthoma-diagnosed-Carcinoma, Squamous Cell', 'Glucose Intolerance-result-Diabetes Mellitus', 'Hyperglycemia-lead-Glucose Metabolism Disorders', 'Alzheimer Disease-exacerbated-Drug-Related Side Effects and Adverse Reactions', 'Hyperhomocysteinemia-associated-Dementia', 'Dementia-associated-Hyperhomocysteinemia', 'Hyperhomocysteinemia-addressed-Dementia', 'Sarcopenia-serve-Death', 'Carcinoma, Squamous Cell-followed-Carcinoma, Basal Cell', 'Alzheimer Disease-decrease-Drug-Related Side Effects and Adverse Reactions', 'Cerebrovascular Disorders-suffer-Cerebral Infarction', 'Cardiac Output, Low-present-Enuresis', 'Cardiac Output, Low-contribute-Fractures, Bone', 'Communicable Diseases-impact-Infections', 'Communicable Diseases-impact-Diarrhea', 'Communicable Diseases-impact-Pneumonia', 'Craniofacial Dysostosis-seen-Intellectual Disability', 'Headache Disorders, Secondary-developed-Prostatic Hyperplasia', 'Calcinosis-predict-Coronary Artery Disease', 'Coronary Artery Disease-converted-Rupture', 'Coronary Artery Disease-converted-Thrombosis', 'Thrombosis-play-Ischemia', 'Thrombosis-participate-Coronary Artery Disease', 'Heart Arrest-provide-Atherosclerosis', 'Cardiovascular Diseases-assessed-Hypertension', 'Cardiovascular Diseases-assessed-Hyperlipidemias', 'Cardiovascular Diseases-assessed-Diabetes Mellitus', 'Cardiovascular Diseases-assessed-Angina Pectoris', 'Cardiovascular Diseases-assessed-Peripheral Vascular Diseases', 'Lymphoma-mimic-Neoplasms', 'Heart Diseases-produce-Hypertrophy', 'Mitral Valve Stenosis-produce-Airway Obstruction', 'Colorectal Neoplasms-appear-Neoplasms', 'Breast Neoplasms-base-Neoplasms', 'Heart Rupture-predispose-Ventricular Remodeling', 'Rupture-predispose-Ventricular Remodeling', 'Dementia-exist-Death', 'Headache Disorders, Secondary-wait-Stomach Neoplasms', 'Pain-reduce-Arthritis, Rheumatoid', "Death-reported-Legionnaires' Disease", 'Anemia, Hemolytic-develop-Kidney Failure, Chronic', 'Takotsubo Cardiomyopathy-contribute-Neurologic Manifestations', 'Heart Septal Defects, Ventricular-prevent-Neurologic Manifestations', 'Blindness-decrease-Rupture', 'Vision Disorders-sustain-Hip Fractures', 'Hydrocephalus-characterized-Hepatomegaly', 'Heart Failure, Diastolic-constitute-Heart Failure', 'Blindness-select-Dementia', 'Blindness-select-Deafness', 'Blindness-select-Aphasia', 'Infections-predispose-Lupus Erythematosus, Systemic', 'Infections-predispose-Neoplasms', 'Infections-predispose-Diabetes Mellitus', 'Infections-predispose-Acquired Immunodeficiency Syndrome', 'Lupus Erythematosus, Systemic-follow-Neoplasms', 'Immunologic Deficiency Syndromes-correlate-Renal Tubular Transport, Inborn Errors', 'Brain Injuries, Traumatic-decrease-Death', 'Death-attributed-Diabetes Mellitus', 'Arachnoid Cysts-associated-Hydrocephalus', 'Hydrocephalus-associated-Arachnoid Cysts', 'Inflammation-upregulate-Neoplasms', 'Inflammation-upregulate-Atherosclerosis', 'Communicable Diseases-diagnose-Osteoporosis', 'Wounds and Injuries-diagnose-Osteoporosis', 'Glucose Metabolism Disorders-include-Neurodegenerative Diseases', 'Glucose Metabolism Disorders-caused-Neurodegenerative Diseases', 'Tachycardia, Supraventricular-prevent-Bradycardia', 'Cardiac Output, Low-increased-Nocturia', 'Polyuria-caused-Diabetes Insipidus', 'Polyuria-caused-Diabetes Mellitus', 'Polyuria-caused-Heart Failure', 'Polyuria-caused-Sleep Wake Disorders', 'Polyuria-fall-Cardiac Output, Low', 'Polyuria-increase-Sleepiness', 'Heart Diseases-associated-Sleep Initiation and Maintenance Disorders', 'Sleep Initiation and Maintenance Disorders-associated-Heart Diseases', 'Sleep Wake Disorders-increase-Sleepiness', 'Cardiac Output, Low-fall-Sleepiness', 'Arthritis-associated-Sleep Wake Disorders', 'Sleep Wake Disorders-associated-Arthritis', 'Lung Diseases-associated-Sleep Wake Disorders', 'Sleep Wake Disorders-associated-Lung Diseases', 'Lung Diseases-associated-Sleep Deprivation', 'Sleep Deprivation-associated-Lung Diseases', 'Headache-referred-Migraine Disorders', 'Headache Disorders, Primary-consult-Headache', 'Osteoporosis-associated-Sleep Wake Disorders', 'Sleep Wake Disorders-associated-Osteoporosis', 'Osteoporosis-associated-Sleep Deprivation', 'Sleep Deprivation-associated-Osteoporosis', 'Headache-occur-Migraine Disorders', 'Atrial Fibrillation-aging-Myocardial Infarction', 'Atrial Fibrillation-aging-Heart Valve Diseases', 'Lipodystrophy-associated-HIV Infections', 'HIV Infections-associated-Lipodystrophy', 'Dyslipidemias-place-Cardiovascular Diseases', 'Atrial Fibrillation-required-Stroke', 'Dementia-required-Stroke', 'Dementia-associated-Ischemia', 'Ischemia-associated-Dementia', 'Dementia-investigate-Stroke', 'Diabetes Mellitus, Type 2-undergo-Diabetes Mellitus', 'Stroke-result-Atherosclerosis', 'Infections-underlie-Skin Diseases', 'Cold Injury-mentioned-Migraine Disorders', 'Migraine Disorders-mentioned-Hemostatic Disorders', 'Kyphosis-included-Dyspnea', 'Renal Insufficiency-involve-Hypotension', 'Renal Insufficiency-hypothesize-Hypotension', 'Heart Failure-involve-Hypotension', 'Heart Failure-hypothesize-Hypotension', 'Atrophy-attributed-Plaque, Amyloid', 'Pain-receive-Diabetes Mellitus', 'Sleep Initiation and Maintenance Disorders-characterized-Voice Disorders', 'Sleep Initiation and Maintenance Disorders-correlated-Sleep Wake Disorders', 'Hypotension, Orthostatic-affect-Parkinson Disease', 'Death-give-Neoplasms', 'Death-enhanced-Malnutrition', 'Death-enhanced-Diabetes Mellitus', 'Oligospermia-consist-Infertility, Female', 'Oligospermia-consist-Azoospermia', 'Azoospermia-consist-Infertility, Female', 'Autoimmune Pancreatitis-consider-Jaundice, Obstructive', 'Fatigue-measure-Tetany', 'Fatigue-fatigue-Peripheral Nervous System Diseases', 'Tetany-associated-Fatigue', 'Fatigue-associated-Tetany', 'Death-caused-Heart Failure', 'HIV Infections-resemble-Parkinsonian Disorders', 'Psychomotor Disorders-resemble-Parkinsonian Disorders', 'Intellectual Disability-underlie-Alzheimer Disease', 'Death-followed-Pneumonia', 'Death-followed-Heart Failure', 'Death-followed-Myocardial Infarction', 'Neoplasms-follow-Multiple Organ Failure', 'Werner Syndrome-characterized-Endocrine System Diseases', 'Genetic Diseases, Inborn-characterized-Endocrine System Diseases', 'Werner Syndrome-associated-Meningeal Neoplasms', 'Meningeal Neoplasms-associated-Werner Syndrome', 'Werner Syndrome-associated-Osteoporosis', 'Osteoporosis-associated-Werner Syndrome', 'Werner Syndrome-report-Osteoporosis', 'Werner Syndrome-associated-Tendinopathy', 'Tendinopathy-associated-Werner Syndrome', 'Werner Syndrome-report-Tendinopathy', 'Cataract-experience-Vision Disorders', 'Werner Syndrome-associated-Osteomyelitis', 'Osteomyelitis-associated-Werner Syndrome', 'Werner Syndrome-report-Osteomyelitis', 'Werner Syndrome-associated-Calcinosis', 'Calcinosis-associated-Werner Syndrome', 'Werner Syndrome-report-Calcinosis', 'Meningeal Neoplasms-report-Osteoporosis', 'Meningeal Neoplasms-report-Tendinopathy', 'Meningeal Neoplasms-report-Osteomyelitis', 'Meningeal Neoplasms-report-Calcinosis', 'Cataract-rehospitalised-Corneal Diseases', 'Cataract-develop-Endophthalmitis', 'Retinal Detachment-rehospitalised-Corneal Diseases', 'Retinal Detachment-develop-Endophthalmitis', 'Corneal Diseases-develop-Endophthalmitis', 'Cardiomyopathies-predict-Hypertrophy', 'Hypertension-related-Vertebrobasilar Insufficiency', 'Pulmonary Disease, Chronic Obstructive-stopp-Respiratory Insufficiency', 'Homocystinuria-caused-Genetic Diseases, Inborn', 'Homocystinuria-disclose-Dementia, Vascular', 'Arteriosclerosis-predispose-Hyperhomocysteinemia', 'Heart Failure-focused-Coronary Artery Disease', 'Heart Failure-accompany-Hypertension', 'Hypotension-accompany-Hypertension', 'Spinal Cord Injuries-examined-Death', 'Meningitis, Bacterial-include-Infections', 'Epilepsia Partialis Continua-observed-Hearing Loss, Central', 'Epilepsia Partialis Continua-observed-Metabolic Diseases', 'Epilepsy-observed-Hearing Loss, Central', 'Epilepsy-observed-Metabolic Diseases', 'Diarrhea-experienced-Exanthema', 'Exanthema-proceed-Drug Eruptions', 'Pain-reduce-Osteoporotic Fractures', 'Hypertension-question-Cardiovascular Diseases', 'Colorectal Neoplasms-underutilized-Drug-Related Side Effects and Adverse Reactions', 'Death-presented-Neoplasms', 'Dementia-coexist-HIV Infections', 'Pain, Postoperative-encountered-Musculoskeletal Diseases', 'Fever-include-Severe Acute Respiratory Syndrome', 'Cerebrovascular Disorders-hypothesize-Dementia, Vascular', 'Cerebrovascular Disorders-hypothesize-Alzheimer Disease', 'Calcinosis-portended-Stroke', 'Calcinosis-portended-Coronary Artery Disease', 'Calcinosis-portended-Death', 'Fractures, Bone-contribute-Cardiovascular Diseases', 'Pain-present-Hyperalgesia', 'Coronary Artery Disease-decrease-Stroke', 'Diabetes Mellitus-experience-Fetal Macrosomia', 'Stroke-prevented-Coronary Artery Disease', 'Polymyalgia Rheumatica-look-Hematuria', 'Polymyalgia Rheumatica-look-Proteinuria', 'Venous Thrombosis-present-Hip Fractures', 'Alzheimer Disease-suggest-Parkinson Disease', 'Nausea-affect-Neoplasms', 'Vomiting-affect-Neoplasms', 'Sleep Wake Disorders-lead-Chronic Pain', 'Sleep Wake Disorders-lead-Pain', 'Chronic Pain-lead-Sleep Wake Disorders', 'Dystonia-handling-Dementia', 'Hodgkin Disease-relapse-Drug Resistant Epilepsy', 'Peritoneal Neoplasms-caused-Diverticulitis, Colonic', 'Brain Injuries, Traumatic-report-Cardiac Output, Low', 'Prostatic Hyperplasia-associated-Prostatic Neoplasms', 'Prostatic Neoplasms-associated-Prostatic Hyperplasia', 'Osteoporosis-associated-Back Pain', 'Back Pain-associated-Osteoporosis', 'Cerebrovascular Disorders-associated-Erectile Dysfunction', 'Erectile Dysfunction-associated-Cerebrovascular Disorders', 'Aortic Aneurysm-operated-Marfan Syndrome', 'Infections-convince-Chronic Disease', 'Infections-convince-Heart Diseases', 'Obesity-exposed-Tuberculosis', 'Alzheimer Disease-pose-Dementia', 'Alzheimer Disease-pose-Death', 'Dementia-pose-Death', 'Fecal Incontinence-related-Muscle Hypertonia', 'Blindness-account-Cataract', 'Blindness-account-Glaucoma', 'Peptic Ulcer-reduced-Hemostatic Disorders', 'Death-reduced-Peptic Ulcer', 'Hemostatic Disorders-reduced-Death', 'Heart Failure-appear-Hypertension', 'Hypertension-occur-Edema', 'Nephrotic Syndrome-related-Leprosy', 'Amyloidosis-occur-Multiple Myeloma', 'Amyloidosis-occur-Colonic Neoplasms', 'Diarrhea-obscure-Ulcer', 'Fecal Incontinence-obscure-Ulcer', 'Fatigue-promote-Weight Loss', 'Hypertension-promote-Weight Loss', 'Hyperkinesis-develop-Alzheimer Disease', 'Fractures, Bone-follow-Osteoporosis', 'Dementia-classify-Alzheimer Disease', 'Sexual Dysfunction, Physiological-include-Fatigue', 'Sexual Dysfunction, Physiological-make-Fatigue', 'Muscular Diseases-result-Atrophy', 'Neoplasms-suffer-Lung Neoplasms', 'Aneurysm-aggravate-Parkinson Disease', 'Aneurysm-control-Parkinson Disease', 'Parkinson Disease-suffer-Stroke', 'Parkinson Disease-suffer-Coronary Artery Disease', 'Parkinson Disease-suffer-Diabetes Mellitus', 'Cardiovascular Abnormalities-identified-Leukemia, Myeloid, Acute', 'Cataract-used-Ocular Hypertension', 'Epilepsy-achieve-Seizures', 'Weight Loss-minimize-Chronic Disease', 'Anemia-range-Muscle Weakness', 'Anemia-lead-Fatigue', 'Anemia-lead-Heart Failure', 'Fatigue-lead-Heart Failure', 'Cardiovascular Diseases-account-Diabetes Mellitus', 'Cross Infection-exacerbate-Infections', 'Hypotension-occur-Infections', 'Hypotension-occur-Wounds and Injuries', 'Alzheimer Disease-associated-Hypogonadism', 'Hypogonadism-associated-Alzheimer Disease', 'Obesity-decrease-Diabetes Mellitus', 'Obesity, Abdominal-decrease-Diabetes Mellitus', 'Arrhythmias, Cardiac-account-Death', 'Prostatic Hyperplasia-caused-Erectile Dysfunction', 'Stroke-remain-Epilepsy, Complex Partial', 'Stroke-remain-Dementia', 'Epilepsy, Complex Partial-remain-Dementia', 'Myocardial Infarction-remain-Cerebrovascular Disorders', 'Stroke-induce-Nerve Degeneration', 'Communicable Diseases-decrease-Death', 'Cardiovascular Diseases-play-Inflammation', 'Diurnal Enuresis-associated-Sleepiness', 'Sleepiness-associated-Diurnal Enuresis', 'Neoplasms-participate-Heart Arrest', 'Osteoporosis-inhibit-Atherosclerosis', 'Cardiovascular Diseases-attributed-Fibrosis', 'Synucleinopathies-include-Parkinson Disease', 'Synucleinopathies-include-Dementia', 'Synucleinopathies-include-Atrophy', 'Synucleinopathies-study-Atrophy', 'Synucleinopathies-include-Tauopathies', 'Synucleinopathies-include-Supranuclear Palsy, Progressive', 'Synucleinopathies-include-Retinal Degeneration', 'Parkinson Disease-account-Atrophy', 'Parkinson Disease-include-Tauopathies', 'Parkinson Disease-include-Supranuclear Palsy, Progressive', 'Parkinson Disease-include-Retinal Degeneration', 'Atrophy-study-Tauopathies', 'Parkinsonian Disorders-account-Parkinson Disease', 'Parkinsonian Disorders-account-Parkinson Disease, Secondary', 'Tauopathies-include-Supranuclear Palsy, Progressive', 'Tauopathies-include-Retinal Degeneration', 'Spasm-play-Angina Pectoris, Variant', 'Death-associated-Acidosis', 'Acidosis-associated-Death', 'Osteoporosis-follow-Fractures, Bone', 'Anemia-associated-Gastritis, Atrophic', 'Gastritis, Atrophic-associated-Anemia', 'Anemia-lead-Malabsorption Syndromes', 'Autoimmune Diseases-associated-Gastritis, Atrophic', 'Gastritis, Atrophic-associated-Autoimmune Diseases', 'Autoimmune Diseases-lead-Malabsorption Syndromes', 'Gastritis, Atrophic-associated-Anemia, Megaloblastic', 'Anemia, Megaloblastic-associated-Gastritis, Atrophic', 'Malabsorption Syndromes-lead-Anemia, Megaloblastic', 'Werner Syndrome-show-Neoplasms', 'Nijmegen Breakage Syndrome-show-Neoplasms', 'Nijmegen Breakage Syndrome-show-Drug Hypersensitivity', 'Genetic Diseases, Inborn-show-Neoplasms', 'Genetic Diseases, Inborn-show-Drug Hypersensitivity', 'Muscular Atrophy-related-HIV Infections', 'Anemia-experience-Cardiac Output, Low', 'Hypoxia, Brain-cause-Headache', 'Hypoxia, Brain-cause-Vertigo', 'Hypoxia, Brain-cause-Tinnitus', 'Parkinsonian Disorders-emerge-Muscle Rigidity', 'Parkinsonian Disorders-emerge-Tremor', 'Basal Ganglia Diseases-emerge-Muscle Rigidity', 'Basal Ganglia Diseases-emerge-Tremor', 'Parkinson Disease-identify-Muscle Rigidity', 'Parkinson Disease-identify-Tremor', 'Tremor-carried-Muscle Rigidity', 'Cataract-cause-Neoplasms', 'Heart Arrest-play-Atrial Fibrillation', 'Diabetes Mellitus-suffer-Myocardial Infarction', 'Diabetes Mellitus-suffer-Heart Failure', 'Metabolic Syndrome-shown-Diabetes Mellitus', 'Metabolic Syndrome-shown-Cardiovascular Diseases', 'Heart Failure-preserve-Heart Failure, Systolic', 'Heart Failure, Systolic-exhibit-Heart Failure, Diastolic', 'Diabetes Mellitus-produce-Cardiomyopathies', 'Diabetes Mellitus-produce-Coronary Artery Disease', 'Diabetes Mellitus-produce-Hypertension', 'Cerebellar Ataxia-occur-Muscle Weakness', 'Hemorrhage-classified-Gastrointestinal Hemorrhage', 'Anemia-classified-Gastrointestinal Hemorrhage', 'Gastrointestinal Hemorrhage-included-Constipation', 'Infections-treated-Death', 'Diabetes Mellitus-targeted-Periodontal Diseases', 'Brain Infarction-based-Stroke', 'Cerebral Infarction-constitute-Stroke', 'Cerebral Infarction-render-Hemorrhage', 'Fractures, Bone-associate-Chronic Disease', 'Chronic Disease-associate-Fractures, Bone', 'Death-co-exist-Ischemia', 'Death-co-exist-Shock', 'Neuralgia-defined-Pain', 'Acute Pain-hast-Exanthema', 'Parkinson Disease-measure-Nervous System Diseases', 'Arbovirus Infections-lead-Pneumonia', 'Diverticulitis-cover-Diverticular Diseases', 'Diverticulitis-develop-Airway Obstruction', 'Epilepsy-analyzed-Seizures', 'Seizures-start-Epilepsy', 'Chickenpox-presented-Diabetes Mellitus', 'Respiratory Distress Syndrome-presented-Diabetes Mellitus', 'Lung Injury-presented-Diabetes Mellitus', 'Encephalitis-presented-Diabetes Mellitus', 'Drug-Related Side Effects and Adverse Reactions-include-Epilepsy', 'Restless Legs Syndrome-share-Akathisia, Drug-Induced', 'Parkinson Disease-manifest-Restless Legs Syndrome', 'Migraine Disorders-respond-Headache', 'Migraine Disorders-recognize-Headache', 'Cataract-cause-Vision, Low', 'Death-influence-Hypotension', 'Death-influence-Bacteremia', 'Stroke-decrease-Dementia, Vascular', 'Hypertension-decrease-Dementia, Vascular', 'Hyperlipidemias-decrease-Dementia, Vascular', 'Tangier Disease-associated-Atherosclerosis', 'Atherosclerosis-associated-Tangier Disease', 'Adrenal Insufficiency-associated-Infertility, Male', 'Infertility, Male-associated-Adrenal Insufficiency', 'Coronary Artery Disease-modify-Death', 'Neoplasms-affected-Prostatic Neoplasms', 'Inflammation-lead-Blindness', 'Obesity-result-Thromboembolism', 'Fractures, Bone-induce-Sarcopenia', 'Lymphoma, B-Cell-obtained-Neoplasms', 'Joint Diseases-relieve-Pain', 'Obesity-prevent-Wounds and Injuries', 'Hepatitis, Viral, Human-increase-Infections', 'Kidney Failure, Chronic-delay-Kidney Diseases', 'Heart Failure-evaluate-Death', 'Abdominal Injuries-include-Wounds and Injuries', 'Insulin Resistance-prevent-Diabetes Mellitus', 'Leukoencephalopathies-correlate-Language Disorders', 'Insulin Resistance-reduce-Cardiovascular Diseases', 'Scabies-experience-Pruritus', 'Hematoma-associated-Meningeal Neoplasms', 'Meningeal Neoplasms-associated-Hematoma', 'Hematoma-show-Blood Platelet Disorders', 'Meningeal Neoplasms-carry-Hematoma', 'Thrombocytopenia-associated-Meningeal Neoplasms', 'Meningeal Neoplasms-associated-Thrombocytopenia', 'Hemostatic Disorders-associated-Hemorrhage', 'Hemorrhage-associated-Hemostatic Disorders', 'Hemostatic Disorders-associated-Meningeal Neoplasms', 'Meningeal Neoplasms-associated-Hemostatic Disorders', 'Stroke-include-Dementia', 'Leukoaraiosis-include-Dementia', 'Liver Cirrhosis, Biliary-suspected-Inflammatory Bowel Diseases', 'Cholangitis-suspected-Inflammatory Bowel Diseases', 'Ascites-point-Hepatitis, Alcoholic', 'Alcoholism-point-Hepatitis, Alcoholic', 'Cholestasis-include-Metabolic Diseases', 'Pruritus-include-Cholestasis', 'Cholestasis-include-Cystic Fibrosis', 'Bone Diseases, Metabolic-include-Cholestasis', 'Cholestasis-include-Biliary Atresia', 'Dyspareunia-distinguish-Erectile Dysfunction', 'Muscle Rigidity-distinguish-Erectile Dysfunction', 'Alzheimer Disease-linked-Death', 'Rhabdomyosarcoma-represent-Sarcoma', 'Meningoencephalitis-caused-Arbovirus Infections', 'Gingivitis-used-Oculocerebrorenal Syndrome', 'Heart Valve Diseases-lead-Calcinosis', 'Neoplasms-predispose-Bone Diseases, Metabolic', 'Vision Disorders-considered-Cataract', 'Ureteral Neoplasms-observed-Werner Syndrome', 'Pain-include-Hemophilia A', 'Hemorrhage-adjusted-Infections', 'Parkinson Disease-compared-Alzheimer Disease', 'Chemical and Drug Induced Liver Injury-perceived-Communicable Diseases', 'Chemical and Drug Induced Liver Injury-perceived-Hepatitis B', 'Hepatitis B-follow-Communicable Diseases', 'Bacteriuria-develop-Urinary Tract Infections', 'Nocturia-associated-Urinary Bladder Neoplasms', 'Urinary Bladder Neoplasms-associated-Nocturia', 'Hypertension-associated-Sepsis', 'Sepsis-associated-Hypertension', 'Hypertension-act-Death', 'Hypertension-act-Sepsis', 'Hypertension-exposed-Communicable Diseases', 'Death-used-Diabetes Mellitus, Type 2', 'Myelitis-produce-Multifocal Choroiditis', 'Neuralgia-persist-Exanthema', 'Meningitis-develop-Cross Infection', 'Death-observed-Meningitis', 'Ischemia-cause-Growth Disorders', 'Central Nervous System Neoplasms-decline-Immunologic Deficiency Syndromes', 'Skin Diseases-trigger-Skin Neoplasms', 'Aneurysm-demonstrate-Angina Pectoris', 'Aneurysm-demonstrate-Myocardial Infarction', 'Aneurysm-demonstrate-Carotid Stenosis', 'Aneurysm-demonstrate-Coronary Artery Disease', 'Aneurysm-demonstrate-Cerebrovascular Disorders', 'Aneuploidy-lead-Genetic Diseases, Inborn', 'Arteriosclerosis-emerge-Gastrointestinal Diseases', 'Arteriosclerosis-suggest-Ischemia', 'Gastrointestinal Diseases-suggest-Ischemia', 'Dyskeratosis Congenita-warranted-Anemia, Aplastic', 'Dyskeratosis Congenita-warranted-Myelodysplastic Syndromes', 'Scoliosis-worsen-Low Back Pain', 'Mobility Limitation-worsen-Low Back Pain', 'Pneumonia-admitted-Pneumococcal Infections', 'Hodgkin Disease-do-Breast Neoplasms', 'Leukemia, Myeloid, Acute-do-Breast Neoplasms', 'Arthritis-underlie-Liver Diseases', 'Malaria-account-Death', 'Pancreatic Neoplasms-examined-Alzheimer Disease', 'Pancreatic Neoplasms-examined-Diabetes Mellitus', 'Drug-Related Side Effects and Adverse Reactions-evaluate-Breast Neoplasms', 'Breast Neoplasms-yield-Fatigue', 'Heart Failure-lead-Heart Diseases', 'Ocular Hypertension-represent-Cataract', 'Dementia-quantify-Stroke', 'Dementia-underestimate-Stroke', 'Fever-diagnosed-Bacterial Infections', 'Fever-show-Brain Diseases', 'Bacterial Infections-show-Brain Diseases', 'Osteoporotic Fractures-sustain-Wounds and Injuries', 'Osteonecrosis-follow-Femoral Neck Fractures', 'Osteonecrosis-follow-Fractures, Bone', 'Constriction, Pathologic-ensue-Ischemia', 'Atherosclerosis-cause-Renal Insufficiency', 'Hypertension-cause-Renal Insufficiency', 'Neoplasms-experience-Chronic Disease', 'Neoplasms-precipitate-Delirium', 'Death-imply-Rupture', 'Aneurysm-show-Diabetes Mellitus', 'Diabetes Mellitus-compare-Kidney Failure, Chronic', 'Lymphopenia-associated-Malnutrition', 'Malnutrition-associated-Lymphopenia', 'Atrophy-associated-Malnutrition', 'Malnutrition-associated-Atrophy', 'Alzheimer Disease-released-Brain Injuries', 'Stroke-defined-Neurologic Manifestations', 'Stomach Neoplasms-include-Neoplasms', 'Death-administered-Myocardial Infarction', 'Myocardial Infarction-administered-Infarction', 'Dementia, Vascular-detect-Ischemia', 'Death-account-Heart Diseases', 'Death-account-Stroke', 'Heart Diseases-account-Stroke', 'Heart Failure, Diastolic-appear-Hypertension', 'Heart Failure, Diastolic-caused-Heart Failure', 'Hypotension-recognized-Heart Failure', 'Cardiovascular Abnormalities-associated-Hypotension', 'Hypotension-associated-Cardiovascular Abnormalities', 'Osteoporosis-recognized-Communicable Diseases', 'Inflammation-associated-Bone Neoplasms', 'Bone Neoplasms-associated-Inflammation', 'Arbovirus Infections-account-Death', 'Acquired Immunodeficiency Syndrome-underlie-Respiratory Tract Diseases', 'Acquired Immunodeficiency Syndrome-underlie-Heart Diseases', 'Acquired Immunodeficiency Syndrome-underlie-Neoplasms', 'Tachycardia-cause-Hypoxia', 'Tachycardia-cause-Hypokalemia', 'Muscle Weakness-perform-Diabetes Mellitus', 'Obesity-raise-Fetal Macrosomia', 'Chronic Disease-raise-Fetal Macrosomia', 'Cholangitis-remain-Biliary Dyskinesia', 'Sepsis-determine-Biliary Dyskinesia', 'Seizures-transmit-Fever', 'Vision Disorders-follow-Macular Degeneration', 'Pain-identify-Wounds and Injuries', 'Death-identify-Wounds and Injuries', 'Cardiac Complexes, Premature-occur-Myocardial Infarction', 'Alcoholism-include-Heredodegenerative Disorders, Nervous System', 'Alcoholism-include-Chronic Disease', 'Acute Disease-judged-Delirium', 'Acute Disease-judged-Infections', 'Cardiomyopathies-judged-Delirium', 'Cardiomyopathies-judged-Infections', 'Hypothermia-fall-Death', 'Hypothermia-occur-Death', 'Nijmegen Breakage Syndrome-demonstrate-Disease', 'Nijmegen Breakage Syndrome-demonstrate-Neoplasms', 'Genetic Diseases, Inborn-demonstrate-Disease', 'Genetic Diseases, Inborn-demonstrate-Neoplasms', 'Osteoarthritis-suffer-Osteoporosis', 'Osteoporosis-compromised-Osteoarthritis', 'Osteoarthritis-increase-Muscular Dystrophy, Duchenne', 'Osteoporosis-suppress-Osteoarthritis', 'Neoplasms-bearing-Stomach Diseases', 'Alzheimer Disease-constitute-Dementia', 'Alzheimer Disease-compare-Cerebral Amyloid Angiopathy', 'Alzheimer Disease-show-Cerebral Amyloid Angiopathy', 'Cerebral Amyloid Angiopathy-contribute-Neurodegenerative Diseases', 'Cerebral Amyloid Angiopathy-contribute-Alzheimer Disease', 'Legionellosis-associated-Death', 'Death-associated-Legionellosis', 'Prostatitis-associated-Death', 'Death-associated-Prostatitis', 'Kidney Diseases-provoke-Hypertension', 'Hypertension-aggravate-Kidney Diseases', 'Kidney Diseases-predispose-Hypertension', 'Diabetes Mellitus-reduce-Renal Insufficiency', 'Neoplasms-treated-Bone Marrow Diseases', 'Cerebral Infarction-limited-Stroke', 'Diarrhea-promote-Constipation', 'Ulcer-attributed-Venous Thrombosis', 'Anemia-followed-Hypertension', 'Prostatic Neoplasms-determine-Neoplasms', 'Prostatic Neoplasms-determine-Drug-Related Side Effects and Adverse Reactions', 'Anemia-followed-Pulmonary Disease, Chronic Obstructive', 'Anemia-followed-Cataract', 'Anemia-followed-Osteoarthritis', 'Antiphospholipid Syndrome-receive-Venous Thromboembolism', 'Antiphospholipid Syndrome-receive-Ischemia', 'Antiphospholipid Syndrome-receive-Thrombocytopenia', 'Antiphospholipid Syndrome-occur-Lupus Erythematosus, Systemic', 'Lupus Erythematosus, Systemic-associated-Thrombosis', 'Thrombosis-associated-Lupus Erythematosus, Systemic', 'Lupus Erythematosus, Systemic-associated-Hemorrhage', 'Hemorrhage-associated-Lupus Erythematosus, Systemic', 'Ocular Hypertension-experience-Glaucoma, Open-Angle', 'Ocular Hypertension-experience-Vision Disorders', 'Glaucoma, Open-Angle-experience-Vision Disorders', 'Osteonecrosis-occur-Aneurysm', 'Tendinopathy-precede-Hypertrophy', 'Carcinoma, Hepatocellular-complicate-Liver Cirrhosis', 'Hereditary Breast and Ovarian Cancer Syndrome-develop-Neoplasms', 'Carcinoma, Hepatocellular-complicate-Arbovirus Infections', 'Drug-Related Side Effects and Adverse Reactions-result-Alzheimer Disease', 'Drug-Related Side Effects and Adverse Reactions-result-Nerve Degeneration', 'Coronary Artery Disease-appear-Atrial Fibrillation', 'Heart Failure-compare-Cardiovascular Diseases', 'Heart Failure-uncomplicated-Cardiovascular Diseases', 'Cardiovascular Diseases-uncomplicated-Heart Failure', 'Werner Syndrome-suffered-Aging, Premature', 'Chronic Disease-experience-Sarcopenia', 'Fractures, Bone-linked-Osteoporosis', 'Neurodegenerative Diseases-learne-Brain Injuries', 'Anemia-impact-Stroke', 'Pulmonary Disease, Chronic Obstructive-assess-Death', 'Stroke-assess-Death', 'Hip Fractures-assess-Death', 'Myocardial Infarction-assess-Death', 'Stroke-modify-Death', 'Atrial Fibrillation-include-Ischemia', 'Ischemia-induced-Cardiovascular Diseases', 'Psychoses, Substance-Induced-demonstrated-Alzheimer Disease', 'Death-associated-Neutropenia', 'Neutropenia-associated-Death', 'Psychoses, Substance-Induced-occur-Parkinson Disease', 'Headache Disorders, Secondary-cause-Parkinson Disease', 'Dyskinesia, Drug-Induced-cause-Parkinson Disease', 'Basal Ganglia Diseases-cause-Parkinson Disease', 'Zollinger-Ellison Syndrome-characterised-Peptic Ulcer', 'Zollinger-Ellison Syndrome-characterised-Diarrhea', 'Zollinger-Ellison Syndrome-associated-Pancreatic Neoplasms', 'Pancreatic Neoplasms-associated-Zollinger-Ellison Syndrome', 'Zollinger-Ellison Syndrome-associated-Gastrinoma', 'Gastrinoma-associated-Zollinger-Ellison Syndrome', 'Peptic Ulcer-associated-Pancreatic Neoplasms', 'Pancreatic Neoplasms-associated-Peptic Ulcer', 'Peptic Ulcer-associated-Gastrinoma', 'Gastrinoma-associated-Peptic Ulcer', 'Diarrhea-associated-Pancreatic Neoplasms', 'Pancreatic Neoplasms-associated-Diarrhea', 'Diarrhea-associated-Gastrinoma', 'Gastrinoma-associated-Diarrhea', 'Parkinsonian Disorders-confused-Parkinson Disease', 'Amyotrophic Lateral Sclerosis-complicated-Spondylosis', 'Spondylosis-associated-Spinal Cord Diseases', 'Spinal Cord Diseases-associated-Spondylosis', 'Spondylosis-associated-Radiculopathy', 'Radiculopathy-associated-Spondylosis', 'Spondylosis-associated-Amyotrophic Lateral Sclerosis', 'Amyotrophic Lateral Sclerosis-associated-Spondylosis', 'Spondylosis-associated-Neurodegenerative Diseases', 'Neurodegenerative Diseases-associated-Spondylosis', 'Amyotrophic Lateral Sclerosis-clarify-Spondylosis', 'Amyotrophic Lateral Sclerosis-clarify-Spinal Diseases', 'Pain-suspect-Sensation Disorders', 'Pain-suspect-Osteoarthritis', 'Pain-suspect-Neurodegenerative Diseases', 'Spondylosis-coexist-Amyotrophic Lateral Sclerosis', 'Neuralgia-suspect-Sensation Disorders', 'Sensation Disorders-suspect-Osteoarthritis', 'Sensation Disorders-suspect-Neurodegenerative Diseases', 'Neuralgia-suspect-Osteoarthritis', 'Neuralgia-suspect-Neurodegenerative Diseases', 'Diabetes Mellitus-suspect-Osteoarthritis', 'Diabetes Mellitus-suspect-Neurodegenerative Diseases', 'Osteoarthritis-suspect-Neurodegenerative Diseases', 'Stroke-track-Death', 'Neurodegenerative Diseases-characterized-Optic Atrophy', 'Optic Atrophy-characterized-Retinal Degeneration', 'Optic Atrophy-characterized-Blindness', 'Schistosomiasis-found-Fascioliasis', 'Atherosclerosis-predict-Peripheral Arterial Disease', 'Peripheral Arterial Disease-associate-Coronary Artery Disease', 'Coronary Artery Disease-associate-Peripheral Arterial Disease', 'Atherosclerosis-assessed-Coronary Artery Disease', 'Heart Diseases-warranted-Cardiovascular Diseases', 'Cardiomyopathies-lead-Arrhythmias, Cardiac', 'Heart Failure-recur-Neoplasms', 'Heart Failure-develop-Neoplasms', 'Stroke-given-Leukoaraiosis', 'Stroke-given-Dementia', 'Muscular Atrophy-contribute-Sarcopenia', 'Neoplasms-known-IgA Vasculitis', 'Death-develop-Fibrosis', 'Fractures, Bone-integrate-Osteoporosis', 'Dyspnea-followed-Fever', 'Dyspnea-followed-Cardiac Output, Low', 'Cough-followed-Fever', 'Cough-followed-Cardiac Output, Low', 'Basal Ganglia Diseases-sedate-Dyskinesia, Drug-Induced', 'Spinal Cord Diseases-sustain-Fractures, Bone', 'Hip Fractures-affect-Osteoporosis', 'Hypertension, Pregnancy-Induced-return-Metabolic Syndrome', 'Diabetes Mellitus-return-Metabolic Syndrome', 'Myotonic Dystrophy-eliminate-Cardiovascular Diseases', 'Respiratory Insufficiency-develop-Infections', 'Respiratory Insufficiency-develop-Pain', 'Hyperlipidemias-diagnosed-Hypertension', 'Hyperlipidemias-diagnosed-Coronary Artery Disease', 'Hepatitis, Alcoholic-associated-Thinness', 'Thinness-associated-Hepatitis, Alcoholic', 'Hepatitis, Alcoholic-associated-Liver Diseases', 'Liver Diseases-associated-Hepatitis, Alcoholic', 'Hepatitis, Alcoholic-associated-Malabsorption Syndromes', 'Malabsorption Syndromes-associated-Hepatitis, Alcoholic', 'Hepatitis, Alcoholic-associated-Hypogonadism', 'Hypogonadism-associated-Hepatitis, Alcoholic', 'Hepatitis, Alcoholic-associated-Hemosiderosis', 'Hemosiderosis-associated-Hepatitis, Alcoholic', 'Hepatitis, Alcoholic-associated-Parathyroid Diseases', 'Parathyroid Diseases-associated-Hepatitis, Alcoholic', 'Alcoholism-associated-Thinness', 'Thinness-associated-Alcoholism', 'Alcoholism-associated-Malabsorption Syndromes', 'Malabsorption Syndromes-associated-Alcoholism', 'Alcoholism-associated-Hypogonadism', 'Hypogonadism-associated-Alcoholism', 'Alcoholism-associated-Hemosiderosis', 'Hemosiderosis-associated-Alcoholism', 'Alcoholism-associated-Parathyroid Diseases', 'Parathyroid Diseases-associated-Alcoholism', 'Bone Diseases-related-Alcoholism', 'Migraine Disorders-diagnosed-Headache', 'Fever-indicate-Infections', 'Carcinoma, Basal Cell-express-Neoplasms', 'Angina, Stable-associated-Death', 'Death-associated-Angina, Stable', 'Death, Sudden, Cardiac-predicted-Diabetes Mellitus', 'Atherosclerosis-use-Chronic Disease', 'Cerebral Hemorrhage-affect-Neurodegenerative Diseases', 'Delirium-relate-Neoplasms', 'Hip Fractures-predispose-Heart Failure', 'Chronic Disease-become-Critical Illness', 'Critical Illness-increase-Neoplasms', 'Osteoporosis-associated-Bacteriuria', 'Bacteriuria-associated-Osteoporosis', 'Memory Disorders-treat-Urinary Incontinence', 'Cardiovascular Diseases-adjusted-Epilepsy', 'Nervous System Diseases-develop-Parkinson Disease, Secondary', 'Nervous System Diseases-develop-Tremor', 'Vision Disorders-mandate-Cataract', 'Myocardial Infarction-living-Heart Failure', 'Hypertension-living-Heart Failure', 'Dyspnea-assessed-Hypertension', 'Stroke-correlate-Alzheimer Disease', 'Syncope-remain-Spondylosis', 'Parkinson Disease-include-Constipation', 'Death-related-Arrhythmias, Cardiac', 'Death-suggested-Arrhythmias, Cardiac', 'Pneumonia-encountered-Asthma', 'Pneumonia-encountered-Pulmonary Disease, Chronic Obstructive', 'Fractures, Bone-assess-Death', 'Fatigue-exhibit-Cardiac Output, Low', 'Hearing Loss-suggest-Atrophy', 'Carcinoid Tumor-report-Pain', 'Death-exert-Glioblastoma', 'Glioblastoma-characterized-Death', 'Brain Neoplasms-characterized-Death', 'Erectile Dysfunction-evaluated-Aneurysm', 'Fractures, Bone-considered-Musculoskeletal Diseases', 'Cystic Fibrosis-suffering-Fractures, Bone', 'Cystic Fibrosis-suffering-Kyphosis', 'Fractures, Bone-increase-Hip Fractures', 'Death-recorded-Drug Overdose', 'Fatigue-related-Anemia', 'Drug Overdose-record-Death', 'Drug Overdose-contract-Infections', 'Drug Overdose-represent-Death', 'Drug Overdose-caused-Infections', 'Drug Overdose-contract-Endocarditis', 'Drug Overdose-confirm-HIV Infections', 'Infections-contract-Endocarditis', 'Pain-associated-Tooth Loss', 'Tooth Loss-associated-Pain', 'Acquired Immunodeficiency Syndrome-experience-Sleep Initiation and Maintenance Disorders', 'Acquired Immunodeficiency Syndrome-experience-Fatigue', 'Neoplasms-collected-Drug-Related Side Effects and Adverse Reactions', 'Drug-Related Side Effects and Adverse Reactions-occur-Nervous System Diseases', 'Drug-Related Side Effects and Adverse Reactions-occur-Thrombocytopenia', 'Sleep Wake Disorders-compare-Sleepiness', 'Hypocapnia-lead-Sleep Wake Disorders', 'Giant Cell Arteritis-result-Rupture', 'Arteritis-considered-Ischemia', 'Hypertension-prove-Cardiovascular Diseases', 'Obesity-accelerate-Heart Failure', 'Diabetes Mellitus-accelerate-Heart Failure', 'Obesity-posed-Musculoskeletal Pain', 'Atherosclerosis-link-Stroke', 'Atherosclerosis-minimize-Stroke', 'Metabolic Syndrome-predict-Coronary Artery Disease', 'Breast Neoplasms-show-Chromosome Disorders', 'Osteoarthritis-lead-Necrosis', 'Necrosis-lead-Osteoarthritis', 'Dementia-tend-Alzheimer Disease', 'Dementia-tend-Cerebrovascular Disorders', 'Dementia-tend-Lewy Body Disease', 'Dementia-tend-Aphasia', 'Hematoma, Subdural-undergo-Hernia, Femoral', 'Headache-show-Hematoma, Subdural', 'Hematoma, Subdural-diagnose-Wounds and Injuries', 'Hematoma, Subdural-discussed-Headache', 'Prostatic Neoplasms-become-Death', 'Melanoma-arise-Carcinoma in Situ', 'Neoplasms-demonstrate-Pain', 'Sick Sinus Syndrome-describe-Arrhythmias, Cardiac', 'Arrhythmias, Cardiac-attributed-Sick Sinus Syndrome', 'Arrhythmias, Cardiac-describe-Sick Sinus Syndrome', 'Heart Diseases-occur-Sick Sinus Syndrome', 'Arrhythmias, Cardiac-describe-Sinus Arrest, Cardiac', 'Sick Sinus Syndrome-screen-Heart Diseases', 'Hypogonadism-occur-Alzheimer Disease', 'Alzheimer Disease-suggest-Hypogonadism', 'Sick Sinus Syndrome-develop-Atrial Fibrillation', 'Tachycardia, Supraventricular-include-Atrial Fibrillation', 'Death-develop-Atrial Fibrillation', 'Stroke-develop-Atrial Fibrillation', 'Heart Failure-develop-Atrial Fibrillation', 'Atrophy-established-Nerve Degeneration', 'Atrophy-established-Alzheimer Disease', 'Hypotension-make-Fractures, Bone', 'Heart Failure-optimize-Cardiovascular Diseases', 'Heart Failure-develop-Hypertension', 'Death-represent-Heart Failure', 'Death-represent-Hypertension', 'Death-represent-Dyslipidemias', 'Death-represent-Obesity', 'Heart Failure-represent-Hypertension', 'Heart Failure-represent-Dyslipidemias', 'Heart Failure-represent-Obesity', 'Onychomycosis-include-Wounds and Injuries', 'Onychomycosis-include-Psoriasis', 'Onychomycosis-include-Vascular Neoplasms', 'Onychomycosis-account-Inflammation', 'Onychomycosis-play-Wounds and Injuries', 'Onychomycosis-play-Arthritis', 'Wounds and Injuries-play-Arthritis', 'Wounds and Injuries-play-Bone Diseases', 'Infections-range-Pyoderma', 'Pyoderma-range-Erysipelas', 'Erysipelas-include-Infections', 'Hepatitis B-live-Hypertension', 'Chemical and Drug Induced Liver Injury-live-Hypertension', 'Inflammation-associated-Stomach Diseases', 'Stomach Diseases-associated-Inflammation', 'Stomach Diseases-compare-Inflammation', 'Intermittent Claudication-accompanied-Coronary Artery Disease', 'Osteoporosis-indicate-Atherosclerosis', 'Neoplasm Metastasis-affected-Neoplasms', 'Osteoporotic Fractures-implicate-Neurologic Manifestations', 'Osteoporotic Fractures-implicate-Pain', 'Parkinson Disease-attributed-Back Pain', 'Low Back Pain-attribute-Parkinson Disease', 'Neurologic Manifestations-result-Ischemia', 'Cerebrovascular Disorders-associated-Cardiac Output, Low', 'Cardiac Output, Low-associated-Cerebrovascular Disorders', 'Parkinson Disease-associated-Cardiac Output, Low', 'Cardiac Output, Low-associated-Parkinson Disease', 'Muscle Rigidity-associated-Cardiac Output, Low', 'Cardiac Output, Low-associated-Muscle Rigidity', 'Hypokinesia-associated-Cardiac Output, Low', 'Cardiac Output, Low-associated-Hypokinesia', 'Cerebral Amyloid Angiopathy-associated-Stroke', 'Stroke-associated-Cerebral Amyloid Angiopathy', 'Alzheimer Disease-associated-Cerebral Hemorrhage', 'Cerebral Hemorrhage-associated-Alzheimer Disease', 'Cerebral Amyloid Angiopathy-occur-Rupture', 'Cerebral Amyloid Angiopathy-occur-Cerebral Hemorrhage', 'Infections-account-Cross Infection', 'Alzheimer Disease-suffer-Brain Injuries, Traumatic', 'Cardiovascular Diseases-measure-Albuminuria', 'Cardiovascular Diseases-measure-Proteinuria', 'Albuminuria-performed-Proteinuria', 'Hookworm Infections-outranked-Malaria', 'Parasitic Diseases-outranked-Malaria', 'Stroke-become-Heart Diseases', 'Amyotrophic Lateral Sclerosis-thought-Neurodegenerative Diseases', 'Digestive System Neoplasms-diagnose-Anemia, Iron-Deficiency', 'Digestive System Neoplasms-diagnose-Stomach Neoplasms', 'Heart Failure-define-Death', 'Renal Insufficiency-recognized-Cardiovascular Diseases', 'Renal Insufficiency-associated-Heart Failure', 'Heart Failure-associated-Renal Insufficiency', 'Death-caused-Hemochromatosis', 'Vision Disorders-result-Stroke', 'Stroke-use-Vision Disorders', 'Stroke-withdrawn-Vision Disorders', 'Alzheimer Disease-reduce-Nerve Degeneration', 'Parkinson Disease-reduce-Nerve Degeneration', 'Epilepsy-occur-Dementia', 'Angina Pectoris-attenuate-Coronary Artery Disease', 'Angina, Stable-result-Coronary Artery Disease', 'Death-developed-Lung Diseases', 'Prostatic Neoplasms-include-Prostatic Diseases', 'Retinal Degeneration-associated-Radiculopathy', 'Radiculopathy-associated-Retinal Degeneration', 'Hypertrophy-associated-Retinal Degeneration', 'Retinal Degeneration-associated-Hypertrophy', 'Hypertrophy-create-Chromosomal Instability', 'Retinal Degeneration-create-Chromosomal Instability', 'Retinal Degeneration-associated-Scoliosis', 'Scoliosis-associated-Retinal Degeneration', 'Retinal Degeneration-associated-Intermittent Claudication', 'Intermittent Claudication-associated-Retinal Degeneration', 'Osteoporosis-facilitate-Musculoskeletal Diseases', 'Heart Failure-evaluated-Hypertension', 'Heart Failure-evaluated-Diabetes Mellitus', 'Heart Failure-evaluated-Alcoholism', 'Heart Failure-interpreted-Muscular Diseases', 'Heart Failure, Diastolic-diagnosed-Hypotension', 'Heart Failure, Diastolic-associated-Coronary Artery Disease', 'Coronary Artery Disease-associated-Heart Failure, Diastolic', 'Wounds and Injuries-needed-Dementia', 'Foot Deformities-result-Pain', 'Arteritis-occur-Polymyalgia Rheumatica', 'Cardiovascular Diseases-cause-Syncope', 'Hypoxia-develop-Respiratory Distress Syndrome', 'Diabetes Mellitus-predict-Atherosclerosis', 'Death-compared-Shock', 'Shock-increase-Death', 'Chemical and Drug Induced Liver Injury-increased-Hyperinsulinism', 'Hip Fractures-associated-Pulmonary Embolism', 'Pulmonary Embolism-associated-Hip Fractures', 'Pulmonary Embolism-associated-Fractures, Bone', 'Fractures, Bone-associated-Pulmonary Embolism', 'Fractures, Bone-carry-Pulmonary Embolism', 'Fractures, Bone-carry-Upper Extremity Deformities, Congenital', 'Graft vs Host Disease-develop-Facial Dermatoses', 'Atherosclerosis-characterized-Arterial Occlusive Diseases', 'Kidney Failure, Chronic-include-Uremia', 'Kidney Failure, Chronic-associated-Uremia', 'Uremia-associated-Kidney Failure, Chronic', 'Atherosclerosis-characterize-Kidney Failure, Chronic', 'Tuberculosis-re-emerge-Infections', 'Death-diagnosed-Tuberculosis', 'Substance-Related Disorders-associated-Tuberculosis', 'Tuberculosis-associated-Substance-Related Disorders', 'Death, Sudden-considered-Death', 'Obesity-render-Diabetes Mellitus', 'Atrial Fibrillation-estimate-Heart Diseases', 'Werner Syndrome-predispose-Neoplasms', 'Chronic Disease-include-Opportunistic Infections', 'Hypogonadism-based-Fractures, Bone', 'Adrenal Insufficiency-develop-Coronary Artery Disease', 'Erectile Dysfunction-develop-Coronary Artery Disease', 'Erectile Dysfunction-develop-Cardiovascular Diseases', 'Osteoarthritis-observed-Cartilage Diseases', 'Infertility, Male-affect-Neoplasms', 'Erectile Dysfunction-include-Ischemia', 'Ischemia-trigger-Fibrosis', 'Death-related-Prostatic Hyperplasia', 'Gastroesophageal Reflux-relieve-Esophageal Neoplasms', 'Osteoporosis-occurring-Fractures, Bone', 'Osteoarthritis-see-Rheumatic Diseases', 'Osteoporosis-see-Rheumatic Diseases', 'Kidney Diseases-attributed-Aneurysm', 'Neoplasms-given-Lymphoma, Non-Hodgkin', 'Inflammatory Bowel Diseases-predict-Death', 'Muscular Dystrophy, Duchenne-include-Osteoporotic Fractures', 'Fractures, Bone-become-Osteoporotic Fractures', 'Hypopituitarism-believed-Cardiovascular Diseases', 'Autoimmune Diseases-caused-Inflammation', 'Arthritis, Rheumatoid-caused-Inflammation', 'Thyroid Diseases-provoke-Atherosclerosis', 'Oculocerebrorenal Syndrome-reduce-Fractures, Bone', 'Polyps-investigate-Asthma', 'Dementia-mention-Sleep Initiation and Maintenance Disorders', 'Chronic Disease-mention-Sleep Initiation and Maintenance Disorders', 'Aortic Diseases-correlated-Dementia', 'Fractures, Bone-reduce-Pain', 'Alzheimer Disease-result-Meningoencephalitis', 'Pain-effect-Hypotension', 'Pain-effect-Fractures, Bone', 'Musculoskeletal Diseases-effect-Hypotension', 'Musculoskeletal Diseases-effect-Fractures, Bone', 'Hypotension-effect-Fractures, Bone', 'Mitral Valve Insufficiency-subjected-Aortic Valve Stenosis', 'Infarction-observed-Infarction, Middle Cerebral Artery', 'Alzheimer Disease-cause-Cardiovascular Abnormalities', 'Delirium-related-Neoplasms', 'Obesity-faced-Coronary Artery Disease', 'Diabetes Mellitus-faced-Coronary Artery Disease', 'Heart Failure-include-Heart Failure, Systolic', 'Myoclonus-caused-Hypoxia, Brain', 'Hypoxia, Brain-associated-Sleep Wake Disorders', 'Sleep Wake Disorders-associated-Hypoxia, Brain', 'Dementia-remain-Intraoperative Awareness', 'Intraoperative Awareness-remain-Alzheimer Disease', 'Death-induce-Necrosis', 'Shock-manifest-Alzheimer Disease', 'Shock-manifest-Hydrocephalus', 'Kidney Diseases-affect-Diabetes Mellitus', 'Coronary Artery Disease-protect-Ischemia', 'Leukemia-classified-Lymphoma', 'Respiratory Tract Diseases-decrease-Death', 'Diabetes Mellitus-reveal-Takotsubo Cardiomyopathy', 'Heart Failure-reveal-Takotsubo Cardiomyopathy', 'Death-increased-Weight Gain', 'Digestive System Neoplasms-fall-Cardiac Output, Low', 'Seizures-overcome-Epilepsy', 'Seizures-focus-Epilepsy', 'Idiopathic Pulmonary Fibrosis-reflect-Lung Neoplasms', 'Idiopathic Pulmonary Fibrosis-correspond-Pneumonia', 'Peripheral Nervous System Diseases-report-Headache', 'Weight Loss-report-Headache', 'Arthritis, Rheumatoid-associated-Dysmenorrhea', 'Dysmenorrhea-associated-Arthritis, Rheumatoid', 'Osteoarthritis-associated-Dysmenorrhea', 'Dysmenorrhea-associated-Osteoarthritis', 'Dysmenorrhea-associated-Pain, Postoperative', 'Pain, Postoperative-associated-Dysmenorrhea', 'Breast Neoplasms-reported-Tuberculosis', 'Breast Neoplasms-reported-Scoliosis', 'Neoplasms-associated-Tinea Capitis', 'Tinea Capitis-associated-Neoplasms', 'Leukemia-associated-Tinea Capitis', 'Tinea Capitis-associated-Leukemia', 'Precursor Cell Lymphoblastic Leukemia-Lymphoma-account-Neoplasms', 'Psychomotor Disorders-associated-Neoplasms', 'Neoplasms-associated-Psychomotor Disorders', 'Pain-compare-Fatigue', 'Neuroendocrine Tumors-associated-Neoplasms', 'Neoplasms-associated-Neuroendocrine Tumors', 'Gastrointestinal Hemorrhage-reveal-Oculocerebrorenal Syndrome', 'Heart Failure-affected-Inflammation', 'Infections-appear-Hyperkinesis', 'Infections-appear-Atherosclerosis', 'Hyperkinesis-appear-Alzheimer Disease', 'Hyperkinesis-appear-Atherosclerosis', 'Lewy Body Disease-correspond-Parkinson Disease', 'Parkinsonian Disorders-correspond-Parkinson Disease', 'Ocular Hypotension-associated-Wounds and Injuries', 'Wounds and Injuries-associated-Ocular Hypotension', 'Intestinal Pseudo-Obstruction-caused-Neoplasms', 'Intestinal Atresia-caused-Neoplasms', 'Death-increase-Intestinal Atresia', 'Arthritis-used-Pain', 'Arthritis-measure-Pain', 'Diabetes Mellitus-represent-Erectile Dysfunction', 'Hypertension-represent-Erectile Dysfunction', 'Atherosclerosis-represent-Erectile Dysfunction', 'Obesity-contribute-Erectile Dysfunction', 'Cardiovascular Diseases-represent-Erectile Dysfunction', 'Chronic Disease-represent-Erectile Dysfunction', 'Arthritis-represent-Erectile Dysfunction', 'Wounds and Injuries-associated-Erectile Dysfunction', 'Erectile Dysfunction-associated-Wounds and Injuries', 'Renal Insufficiency-represent-Erectile Dysfunction', 'Lung Diseases-represent-Erectile Dysfunction', 'Vitreous Hemorrhage-occur-Wounds and Injuries', 'Neoplasms-continue-Pelvic Neoplasms', 'Alzheimer Disease-used-Stroke', 'Death-fail-Ossification of Posterior Longitudinal Ligament', 'HIV Infections-result-Acquired Immunodeficiency Syndrome', 'Infections-manage-Hyperlipidemias', 'Infections-manage-Diabetes Mellitus', 'Infections-manage-Cardiovascular Diseases', 'Renal Insufficiency-associated-Atherosclerosis', 'Atherosclerosis-associated-Renal Insufficiency', 'Cerebrovascular Disorders-associated-Atherosclerosis', 'Atherosclerosis-associated-Cerebrovascular Disorders', 'Atherosclerosis-suspected-Coronary Artery Disease', 'Atherosclerosis-suspected-Hypertension', 'Atherosclerosis-suspected-Renal Insufficiency', 'Atherosclerosis-suspected-Cerebrovascular Disorders', 'Hyperlipoproteinemia Type II-treat-Cardiovascular Diseases', 'Neurodegenerative Diseases-mediated-Inflammation', 'Pulmonary Disease, Chronic Obstructive-show-Airway Obstruction', 'Hemorrhage-tend-Hypertension', 'Wounds, Nonpenetrating-carry-Death', 'Liver Cirrhosis-carry-Death', 'Aneuploidy-demonstrated-Infertility, Male', 'Adenoma-used-Parathyroid Neoplasms', 'Hyperparathyroidism-develop-Hypoparathyroidism', 'Nervous System Diseases-occur-Basal Ganglia Diseases', 'Nervous System Diseases-occur-Dyskinesia, Drug-Induced', 'Pain-improve-Communication Disorders', 'Glaucoma, Angle-Closure-lead-Death', 'Goiter-caused-Congenital Hypothyroidism', 'Goiter-caused-Malnutrition', 'Vertigo-play-Sensation Disorders', 'Nervous System Diseases-include-Urinary Incontinence', 'Brucellosis-seen-Chronic Disease', 'Hernia-carry-Seroma', 'Abnormalities, Drug-Induced-found-Seroma', 'Hernia-found-Seroma', 'Diabetes Mellitus-affect-Idiopathic Pulmonary Fibrosis', 'Idiopathic Pulmonary Fibrosis-related-Diabetes Mellitus', 'Sleep Wake Disorders-caused-Airway Obstruction', 'Sleep Apnea Syndromes-caused-Airway Obstruction', 'Sleep Wake Disorders-resemble-Dementia', 'Heart Valve Diseases-include-Heart Failure', 'Fever-tested-Infections', 'Riboflavin Deficiency-implicated-Neoplasms', 'Infections-define-Fever', 'Breast Neoplasms-consider-Obesity', 'Breast Neoplasms-associate-Neoplasms', 'Neoplasms-associate-Breast Neoplasms', 'Hypertension-develop-Hypotension', 'Cystitis-superimposed-Infections', 'Drug-Related Side Effects and Adverse Reactions-include-Vomiting', 'Pain, Postoperative-remain-Cataract', 'Pain, Postoperative-developed-Vision Disorders', 'Chest Pain-associated-Gastroesophageal Reflux', 'Gastroesophageal Reflux-associated-Chest Pain', 'Fatty Liver-identify-Carcinoma, Hepatocellular', 'Fibrosis-identify-Carcinoma, Hepatocellular', 'Hepatitis C-monitored-Carcinoma, Hepatocellular', 'Fatty Liver-monitored-Carcinoma, Hepatocellular', 'Back Pain-sent-Pain', 'Atrophy-identified-Stroke', 'Paraproteinemias-present-Plasmacytoma', 'Cerebrovascular Disorders-document-Unconsciousness', 'Unconsciousness-document-Cerebrovascular Disorders', 'Cerebrovascular Disorders-associated-Craniocerebral Trauma', 'Craniocerebral Trauma-associated-Cerebrovascular Disorders', 'Parkinsonian Disorders-experience-Sleep Initiation and Maintenance Disorders', 'Parkinsonian Disorders-experience-Parasomnias', 'Parkinsonian Disorders-experience-Disorders of Excessive Somnolence', 'REM Sleep Behavior Disorder-caused-Nerve Degeneration', 'Parkinson Disease, Secondary-develop-REM Sleep Behavior Disorder', 'REM Sleep Behavior Disorder-develop-Parkinson Disease, Secondary', 'Eye Diseases-lead-Blindness', 'Glaucoma-halt-Eye Diseases', 'Diabetes Mellitus-account-Kidney Failure, Chronic', 'Diabetes Mellitus-include-Kidney Failure, Chronic', 'Diabetes Mellitus-include-Diabetic Nephropathies', 'Kidney Failure, Chronic-include-Diabetic Nephropathies', 'Death-reduce-Diabetic Nephropathies', 'Subarachnoid Hemorrhage-prevail-Stroke', 'Cerebral Infarction-seem-Nasal Septal Perforation', 'Cerebral Infarction-seem-Thrombophilia', 'Atherosclerosis-display-Neoplasms', 'Osteoporosis-display-Neoplasms', 'Otitis Externa-affect-Diabetes Mellitus', 'Cataract-display-Neoplasms', 'Infections-affect-Diabetes Mellitus', 'Death-obtained-Spinal Stenosis', 'Weight Loss-present-Dementia', 'Diabetes Mellitus-make-Glucose Intolerance', 'Necrosis-plasma-Pulmonary Disease, Chronic Obstructive', 'Chagas Disease-reflect-Weight Loss', 'Headache Disorders, Secondary-include-Breast Neoplasms', 'Kidney Failure, Chronic-associated-Malnutrition', 'Malnutrition-associated-Kidney Failure, Chronic', 'Sleep Initiation and Maintenance Disorders-stands-Urinary Incontinence', 'Sleep Initiation and Maintenance Disorders-stands-Cardiac Output, Low', 'Sleep Initiation and Maintenance Disorders-do-Cardiac Output, Low', 'Diabetes Mellitus-compared-Chronic Disease', 'Memory Disorders-constitute-Alzheimer Disease', 'Diabetes Mellitus-demonstrate-Heart Diseases', 'Neoplasms-recruit-Hip Dislocation, Congenital', 'Muscular Diseases-include-Heart Failure', 'Death-predict-Muscular Diseases', 'Thrombosis-estimate-Hantavirus Pulmonary Syndrome', 'Neurodegenerative Diseases-accompany-Neoplasms', 'Corneal Diseases-underlie-Neurologic Manifestations', 'Cataract-underlie-Neurologic Manifestations', 'Glaucoma-underlie-Neurologic Manifestations', 'Macular Degeneration-underlie-Neurologic Manifestations', 'Blood Platelet Disorders-involved-Thrombosis', 'Blood Platelet Disorders-involved-Atherosclerosis', 'Blood Platelet Disorders-involved-Inflammation', 'Colonic Neoplasms-correlate-Colorectal Neoplasms', 'Malaria-place-Infections', 'Common Cold-deter-Pulmonary Embolism', 'Bone Diseases, Metabolic-minimize-Postpartum Hemorrhage', 'Asthma-confused-Cough', 'Cough-confused-Pulmonary Disease, Chronic Obstructive', 'Asthma-excluded-Pneumonia, Aspiration', 'Asthma-excluded-Pulmonary Embolism', 'Endocarditis-underlie-Heart Diseases', 'Endocarditis-develop-Plaque, Atherosclerotic', 'Heart Diseases-develop-Plaque, Atherosclerotic', 'Aortic Valve Stenosis-related-Calcinosis', 'Heart Failure-develop-Aortic Valve Insufficiency', 'Airway Obstruction-occur-Death', 'Memory Disorders-observed-Alzheimer Disease', 'Cardiovascular Diseases-prevent-Stroke', 'Stroke-share-Chronic Disease', 'Stroke-share-Coronary Artery Disease', 'Shock, Septic-occur-Death', 'Leukemia, Myeloid, Acute-develop-Fever', 'Leukemia, Myeloid, Acute-develop-Pneumonia', 'Leukemia, Myeloid, Acute-treated-Infections', 'Lymphoma-develop-Fever', 'Lymphoma-develop-Pneumonia', 'Lymphoma-treated-Infections', 'Fever-treated-Infections', 'Pneumonia-treated-Infections', 'Progeria-observe-Uniparental Disomy', 'Adenoma-noted-Adenocarcinoma', 'Death-dominated-Cough', 'Alzheimer Disease-include-Cerebrovascular Disorders', 'Cardiac Output, Low-aggravate-Heart Failure', 'Rhabdomyolysis-defined-Myalgia', 'Rhabdomyolysis-defined-Muscle Weakness', 'Colorectal Neoplasms-become-Chronic Disease', 'Epilepsy, Temporal Lobe-associated-Alzheimer Disease', 'Alzheimer Disease-associated-Epilepsy, Temporal Lobe', 'Status Epilepticus-under-recognised-Coma', 'Status Epilepticus-occur-Heart Arrest', 'Immunologic Deficiency Syndromes-assess-Aneurysm', 'Neoplasms-exist-Multiple Myeloma', 'Leg Injuries-play-Cardiovascular Diseases', 'Death-result-Heart Failure', 'Mastocytosis, Systemic-associated-von Willebrand Diseases', 'von Willebrand Diseases-associated-Mastocytosis, Systemic', 'Chemical and Drug Induced Liver Injury-associated-von Willebrand Diseases', 'von Willebrand Diseases-associated-Chemical and Drug Induced Liver Injury', 'Fractures, Bone-used-Osteoporotic Fractures', 'HIV Infections-address-Lipodystrophy', 'Chromosome Aberrations-associated-Myelodysplastic Syndromes', 'Myelodysplastic Syndromes-associated-Chromosome Aberrations', 'Pancytopenia-develop-Leukemia, Lymphoid', 'Peripheral Arterial Disease-aimed-Death', 'Peripheral Arterial Disease-result-Atherosclerosis', 'Hepatitis C, Chronic-result-Liver Diseases', 'Peripheral Arterial Disease-defined-Pain', 'Hepatitis-develop-Infections', 'Intermittent Claudication-defined-Pain', 'CADASIL-cause-Alzheimer Disease', 'Leukoencephalopathies-cause-Alzheimer Disease', 'Vision Disorders-represent-Alzheimer Disease', 'Alzheimer Disease-cause-Leukoencephalopathies', 'Thrombosis-assessed-Drug-Related Side Effects and Adverse Reactions', 'Gastritis, Atrophic-explain-Hyperhomocysteinemia', 'Diabetes Mellitus, Type 2-compound-Obesity', 'Heart Arrest-observed-Neoplasms', 'Neoplasms-undergo-Heart Arrest', 'Neoplasms-show-Heart Arrest', 'Heart Arrest-show-Neoplasms', 'Heart Arrest-exploited-Neoplasms', 'Atrial Fibrillation-followed-Cerebrovascular Disorders', 'Pain-feel-Death', 'Heterotaxy Syndrome-occur-Ciliary Motility Disorders', 'Heterotaxy Syndrome-suggest-Ciliary Motility Disorders', 'Ciliary Motility Disorders-reported-Heterotaxy Syndrome', 'Heart Failure-predispose-Atrial Fibrillation', 'Muscular Diseases-induced-Tachycardia', 'Heart Failure-manifest-Hypotension', 'Heart Diseases-cause-Ventricular Dysfunction', 'Hypotension-evidenced-Ventricular Dysfunction', 'Atherosclerosis-spreading-Hypertension, Renovascular', 'Death-represent-Hypertension, Renovascular', 'Heart Diseases-overcome-Arterial Occlusive Diseases', 'Prostatic Neoplasms-issued-Neoplasms', 'Immunologic Deficiency Syndromes-contribute-Abnormalities, Drug-Induced', 'Cockayne Syndrome-include-Neurodegenerative Diseases', 'Hypertension-worsen-Hypertrophy', 'Wounds and Injuries-result-Femoral Fractures', 'Wounds and Injuries-result-Bursitis', 'Hip Dislocation, Congenital-lead-Osteoarthritis', 'Death-prove-Ulcer', 'Drug-Related Side Effects and Adverse Reactions-provide-Lymphoma, Non-Hodgkin', 'Wounds and Injuries-succumb-Mycoses', 'Mycoses-succumb-Infections', 'Diabetes Mellitus-linked-Obesity', 'Kidney Diseases-consist-Hypertrophy', 'Hepatolenticular Degeneration-maintain-Hereditary Angioedema Type III', 'Communicable Diseases-contribute-Immune System Diseases', 'Death-contribute-Immune System Diseases', 'Postpartum Hemorrhage-preserve-Fractures, Bone', 'Infections-protect-Hernia, Hiatal', 'Hemolytic-Uremic Syndrome-ascribed-Kidney Diseases', 'Cerebral Infarction-measured-Carotid Stenosis', 'Atherosclerosis-measured-Carotid Stenosis', 'Renal Insufficiency, Chronic-recognised-Tendinopathy', 'Cardiovascular Diseases-receive-Hypertension', 'Atrophy-become-Fragile X Syndrome', 'Prostatic Hyperplasia-express-Gangliosidosis, GM1', 'Death, Sudden-include-Death', 'Hypertension-increase-Infarction', 'Seizures-exhibit-Paraplegia', 'Death-predict-Multiple Organ Failure', 'Death-predict-Hypotension', 'Death-correlated-Hypotension', 'Death-correlated-Multiple Organ Failure', 'Hypotension-correlated-Multiple Organ Failure', 'Infections-emerge-Renal Insufficiency', 'Infections-emerge-Encephalitis', 'Dysentery-emerge-Renal Insufficiency', 'Dysentery-emerge-Encephalitis', 'Kidney Diseases-develop-Heart Failure', 'Renal Insufficiency-represent-Heart Failure', 'Metabolic Diseases-related-Kidney Diseases', 'Metabolic Diseases-induce-Cardiomyopathies', 'Kidney Diseases-induce-Cardiomyopathies', 'Death-involved-Heart Failure', 'Arthritis, Rheumatoid-sustain-Hip Fractures', 'Kidney Diseases-recognized-Hypertension', 'Neoplasms-include-Carcinogenesis', 'Neoplasms-minimize-Carcinogenesis', 'Glomerulonephritis-recognized-Hypertension', 'Ischemia-challenge-Glomerulonephritis', 'Thrombosis-treated-Carcinoma in Situ', 'Dwarfism-established-Pituitary Diseases', 'Agnosia-develop-Neurodegenerative Diseases', 'Agnosia-precede-Alzheimer Disease', 'Pulmonary Disease, Chronic Obstructive-calculated-Airway Obstruction', 'Bronchitis-reported-Asthma', 'Pulmonary Disease, Chronic Obstructive-reported-Asthma', 'Opportunistic Infections-become-HIV Infections', 'HIV Infections-result-Metabolic Diseases', 'Pruritus-encountered-HIV Infections', 'Pruritus-provoke-Sleep Wake Disorders', 'Pruritus-include-Infections', 'Pruritus-include-Skin Diseases, Papulosquamous', 'Pruritus-include-Photosensitivity Disorders', 'Pruritus-include-Lymphoproliferative Disorders', 'HIV Infections-associated-Pruritus', 'Pruritus-associated-HIV Infections', 'Ovarian Neoplasms-arise-Obesity', 'Hirsutism-offer-Acne Vulgaris', 'Euthyroid Sick Syndromes-cross-tabulate-Sepsis', 'Renal Artery Obstruction-show-Renal Insufficiency', 'Colonic Neoplasms-undergo-Esophageal Motility Disorders', 'Colonic Neoplasms-performed-Neoplasms', 'Esophageal Motility Disorders-performed-Neoplasms', 'Neoplasms-performed-Ocular Motility Disorders', 'Esophageal Motility Disorders-identified-Ocular Motility Disorders', 'Hypertension-conducted-Kidney Diseases', 'Leprosy, Lepromatous-diagnosed-Prostatic Neoplasms', 'Blister-considered-Hemorrhage', 'Blister-considered-Constriction, Pathologic', 'Neoplasms-treated-Leukemia, Myeloid, Acute', 'Arbovirus Infections-lead-Infections', 'Syncope-combine-Sleep Initiation and Maintenance Disorders', 'Unconsciousness-combine-Sleep Initiation and Maintenance Disorders', 'Musculoskeletal Diseases-observed-Osteoporotic Fractures', 'Bradycardia-identified-Tachycardia, Ventricular', 'Hip Fractures-associated-Obesity', 'Obesity-associated-Hip Fractures', 'Thrombosis-considered-Pulmonary Embolism', 'Acute Kidney Injury-silence-Neoplasms', 'Carcinoma, Non-Small-Cell Lung-bear-Death', 'Immunologic Deficiency Syndromes-masquerade-Gait Disorders, Neurologic', 'Weight Loss-improve-Chronic Disease', 'Obesity-improve-Chronic Disease', 'Death-show-Renal Insufficiency', 'Diabetes Mellitus-vary-Obesity', 'Urinary Incontinence-predict-Death', 'Chronic Disease-lose-Urinary Incontinence', 'Pyelonephritis-associated-Kidney Diseases', 'Kidney Diseases-associated-Pyelonephritis', 'Infections-considered-Bacterial Infections', 'Obesity-followed-Cardiovascular Diseases', 'Klebsiella Infections-cause-Cystitis', 'Diabetes Mellitus-include-Klebsiella Infections', 'Prostatic Neoplasms-consist-Neoplasms', 'Kidney Failure, Chronic-consider-Death', 'Arthritis-place-Fatigue', 'Arthritis-place-Pain', 'Alzheimer Disease-extend-Atrophy', 'Muscular Atrophy-affect-Heart Arrest', 'Alzheimer Disease-combined-Atrophy', 'Neoplasms-observed-Adenoma', 'Leukemia-up-regulated-Neoplasms', 'Hypertension-cause-Kidney Diseases', 'Drug-Related Side Effects and Adverse Reactions-registered-Anemia', 'Drug-Related Side Effects and Adverse Reactions-registered-Diarrhea', 'Waterborne Diseases-found-Hypopituitarism', 'Obesity-lead-Hypertension', 'Obesity-lead-Coronary Artery Disease', 'Anemia-attributed-Chronic Disease', 'Anemia-underlie-Chronic Disease', 'Anemia-implicated-Cardiac Output, Low', 'Aneurysm-undergo-Death', 'Kidney Diseases-reveal-Death', 'Atherosclerosis-reveal-Death', 'Myocardial Infarction-reveal-Death', 'Fractures, Bone-measure-Bone Neoplasms', 'Fractures, Bone-predict-Muscular Dystrophy, Duchenne', 'Muscular Dystrophy, Duchenne-predict-Hip Fractures', 'Heterotaxy Syndrome-suggest-Hypotension', 'Pulmonary Disease, Chronic Obstructive-fund-Chronic Disease', 'Osteonecrosis-caused-Leukostasis', 'Pulmonary Disease, Chronic Obstructive-involve-Asthma', 'Urinary Bladder Neoplasms-based-Prostatitis', 'Urinary Bladder Neoplasms-based-Airway Obstruction', 'Airway Obstruction-based-Prostatitis', 'Prostatic Hyperplasia-prevent-Death', 'Prostatic Hyperplasia-prevent-Kidney Failure, Chronic', 'Death-prevent-Kidney Failure, Chronic', 'Urinary Bladder Diseases-used-Prostatic Hyperplasia', 'Pruritus-occur-Cerebral Infarction', 'Pruritus-occur-Paraneoplastic Syndromes', 'Headache Disorders, Secondary-fall-Cardiac Output, Low', 'Atrial Fibrillation-determine-Stroke', 'Cardiac Output, Low-fall-Headache Disorders, Secondary', 'Hypertension-associated-Cardiomyopathy, Hypertrophic', 'Cardiomyopathy, Hypertrophic-associated-Hypertension', 'Brain Injuries-give-Glucose Metabolism Disorders', 'Heart Failure-suffer-Oculocerebrorenal Syndrome', 'Alzheimer Disease-believed-Dementia', 'Gastritis-precede-Neoplasms', 'Gastritis-precede-Esophageal Neoplasms', 'Infections-generate-Gastritis', 'Infections-followed-Gastritis', 'Death-prevented-Neoplasms', 'Stomach Neoplasms-prevented-Neoplasms', 'Kidney Diseases-correlate-Diabetes Mellitus', 'Azotemia-document-Hypovolemia', 'Death-worsened-Renal Insufficiency', 'Infections-worsened-Renal Insufficiency', 'Memory Disorders-discussed-Dementia', 'Cerebrovascular Disorders-result-Dementia', 'Diabetes Mellitus-manifest-Hypotension', 'Neutropenia-show-Infections', 'Heart Failure-reserved-Myocardial Infarction', 'Ischemia-improve-Angina Pectoris', 'Coronary Artery Disease-improve-Angina Pectoris', 'Xerostomia-lead-Peptic Ulcer', 'Drug-Related Side Effects and Adverse Reactions-think-Carcinoma, Non-Small-Cell Lung', 'Stroke-take-Cardiovascular Diseases', 'Blindness-affect-Aphakia', 'Myocardial Infarction-found-Cardiomyopathy, Hypertrophic', 'Lymphoma, B-Cell-represent-Lymphoma', 'Venous Thrombosis-protect-Pulmonary Embolism', 'Venous Thrombosis-reduce-Death', 'Pulmonary Embolism-reduce-Death', 'Diabetes Mellitus-occur-Edema', 'Edema-occur-Diabetes Mellitus', 'Diabetes Mellitus-accelerate-Cataract', 'Infections-follow-Pancreatitis, Acute Necrotizing', 'Infections-occur-Pancreatitis, Acute Necrotizing', 'Neoplasms-cause-Pain', 'Neoplasms-cause-Arthritis', 'Neoplasms-cause-Low Back Pain', 'Neoplasms-cause-Polymyalgia Rheumatica', 'Neoplasms-cause-Nervous System Diseases', 'Neoplasms-cause-Peripheral Vascular Diseases', 'Neoplasms-cause-Coronary Artery Disease', 'Drug Hypersensitivity-develop-Fibrosis', 'Dyskeratosis Congenita-characterized-Pigmentation Disorders', 'Arthritis-predisposed-Infections', 'Dyskeratosis Congenita-characterized-Macular Degeneration', 'Dyskeratosis Congenita-characterized-Leukoplakia', 'Genetic Diseases, Inborn-characterized-Pigmentation Disorders', 'Genetic Diseases, Inborn-characterized-Macular Degeneration', 'Genetic Diseases, Inborn-characterized-Leukoplakia', 'Death-undergo-Iatrogenic Disease', 'Neoplasms-matched-Osteosarcoma', 'Death-associated-Splenic Diseases', 'Splenic Diseases-associated-Death', 'Splenic Diseases-result-Postpartum Hemorrhage', 'Alzheimer Disease-prevent-Dyskinesia, Drug-Induced', 'Neoplasms-associated-Myositis', 'Myositis-associated-Neoplasms', 'Salmonella Infections-described-Death', 'Metabolic Diseases-fuel-Neoplasms', 'Chromosome Disorders-fuel-Neoplasms', 'Chronobiology Disorders-associated-Dyspnea', 'Dyspnea-associated-Chronobiology Disorders', 'Chronobiology Disorders-associated-Death', 'Death-associated-Chronobiology Disorders', 'Hypertension-occur-Hypotension', 'Hypertension-mark-Hypotension', 'Cardiomyopathies-induced-Tachycardia', 'Atrial Fibrillation-target-Scimitar Syndrome', 'Cardiovascular Abnormalities-suspect-Ischemia', 'Cardiomyopathies-reduce-Stroke', 'Cardiomyopathies-reduce-Thromboembolism', 'Cardiomyopathies-prevent-Atrial Remodeling', 'Stroke-prevent-Atrial Remodeling', 'Thromboembolism-prevent-Atrial Remodeling', 'Dementia-reduce-Obesity', 'Dementia-reduce-Hypertension', 'Cardiomyopathy, Hypertrophic-reduce-Stroke', 'Stroke-demonstrate-Diabetes Mellitus', 'Sleep Initiation and Maintenance Disorders-increase-Alzheimer Disease', 'Neurotoxicity Syndromes-result-Neurodegenerative Diseases', 'Pain-caused-Neurologic Manifestations', 'Pain-typified-Diabetic Neuropathies', 'Pain-treat-Diabetic Neuropathies', 'Diabetic Neuropathies-treat-Neuralgia', 'Pain-treat-Neuralgia', 'Alzheimer Disease-emphasize-Memory Disorders', 'Cardiovascular Diseases-precipitate-Alzheimer Disease', 'Memory Disorders-emphasize-Dementia', 'Sjogren-Larsson Syndrome-reflect-Dermatitis', 'Inflammation-increase-Prostatic Hyperplasia', 'Parkinsonian Disorders-manifest-Muscle Rigidity', 'Parkinsonian Disorders-manifest-Hypokinesia', 'Muscle Rigidity-manifest-Parkinson Disease', 'Hypokinesia-manifest-Parkinson Disease', 'Immunologic Deficiency Syndromes-demonstrate-Goiter', 'Pneumonia-recorded-Death', 'Infections-recorded-Death', 'Pulmonary Embolism-recorded-Death', 'Myotonic Dystrophy-associated-Heart Failure', 'Heart Failure-associated-Myotonic Dystrophy', 'Myotonic Dystrophy-associated-Atrial Fibrillation', 'Atrial Fibrillation-associated-Myotonic Dystrophy', 'Myotonic Dystrophy-associated-Oliguria', 'Oliguria-associated-Myotonic Dystrophy', 'Hypotension-institute-Myotonic Dystrophy', 'Heart Failure-institute-Myotonic Dystrophy', 'Sensation Disorders-include-Pain', 'Neurologic Manifestations-include-Pain', 'Hypertension-treat-Angina Pectoris', 'Hypertension-treat-Myocardial Infarction', 'Pain-last-Neoplasms', 'Cardiovascular Diseases-seem-Dementia, Vascular', 'Gliosis-include-Alzheimer Disease', 'Cerebral Hemorrhage-include-Alzheimer Disease', 'Gliosis-include-Cerebrovascular Disorders', 'Cerebrovascular Disorders-include-Cerebral Hemorrhage', 'Cerebrovascular Disorders-develop-Cerebral Hemorrhage', 'Gliosis-develop-Cerebral Hemorrhage', 'Alzheimer Disease-lead-Stroke', 'Neutropenia-compare-Neoplasms', 'Heart Failure-control-Fatigue', 'Neoplasms-include-Common Cold', 'Myocardial Infarction-observed-Atherosclerosis', 'Alzheimer Disease-refer-Dementia', 'Dementia-refer-Alzheimer Disease', 'Alzheimer Disease-followed-Lewy Body Disease', 'Alzheimer Disease-calculate-Dementia', 'Lewy Body Disease-calculate-Dementia', 'Dementia, Vascular-calculate-Dementia', 'Sclerosis-calculate-Dementia', 'Aortic Aneurysm, Thoracic-associated-Necrosis', 'Necrosis-associated-Aortic Aneurysm, Thoracic', 'Necrosis-accelerated-Hypertension', 'Necrosis-predispose-Aortic Diseases', 'Hypertension-predispose-Aortic Diseases', 'Marfan Syndrome-predispose-Aortic Aneurysm, Thoracic', 'Infections-use-Respiratory Syncytial Virus Infections', 'Alzheimer Disease-contribute-Cataract', 'HIV Infections-control-Immunologic Deficiency Syndromes', 'HIV Infections-lead-Immunologic Deficiency Syndromes', 'Dementia-followed-Memory Disorders', 'Alzheimer Disease-followed-Memory Disorders', 'Carcinogenesis-involved-Nerve Degeneration', 'Carcinogenesis-seem-Neurodegenerative Diseases', 'Nerve Degeneration-involve-Neurodegenerative Diseases', 'Migraine Disorders-used-Epilepsy', 'Breast Neoplasms-confined-Neoplasms', 'Stroke-decline-Subarachnoid Hemorrhage', 'Hip Fractures-contribute-Craniocerebral Trauma', 'Craniocerebral Trauma-contribute-Death', 'Bone Neoplasms-prevent-Craniocerebral Trauma', 'Fractures, Bone-include-Stroke', 'Seizures-include-Fractures, Bone', 'Hip Fractures-include-Stroke', 'Hip Fractures-live-Stroke', 'Seizures-include-Hip Fractures', 'Diabetes Mellitus-accelerate-Dyslipidemias', 'Arbovirus Infections-known-Death', 'Fractures, Bone-submit-Death', 'Fractures, Bone-determine-Death', 'Death-show-Atherosclerosis', 'Cardiomyopathy, Hypertrophic-increased-Cardiovascular Diseases', 'Inflammation-induce-Rheumatic Fever', 'Infarction-influence-Death', 'Multiple Organ Failure-receive-Carotid Artery Diseases', 'Spinal Cord Diseases-involve-Constriction, Pathologic', 'Alzheimer Disease-consider-Neurodegenerative Diseases', 'Joint Diseases-target-Osteoarthritis', 'Heart Failure-report-Lung Diseases', 'Heart Failure-report-Arthritis', 'Pneumonia, Pneumocystis-diagnose-Immunologic Deficiency Syndromes', 'Renal Insufficiency-distinguish-Death', 'Heart Failure-experience-Heart Diseases', 'Heart Failure-experience-Hypoxia', 'Heart Failure-experience-Arrhythmias, Cardiac', 'Heart Failure-experience-Hypertension', 'Heart Failure-experience-Hypotension', 'Hypertension-marked-Hypoxia', 'Hypertension-marked-Arrhythmias, Cardiac', 'Cardiovascular Diseases-prevent-Blood Platelet Disorders', 'Cardiovascular Diseases-inhibit-Thrombosis', 'Cardiovascular Diseases-prevent-Neoplasms', 'Cardiovascular Diseases-prevent-Arthritis', 'Cardiovascular Diseases-inhibit-Cataract', 'Heart Failure-centred-Heart Failure, Systolic', 'Heart Failure-account-Heart Failure, Systolic', 'Headache Disorders, Secondary-followed-Cardiovascular Diseases', 'Hyponatremia-followed-Cardiovascular Diseases', 'Seizures-followed-Cardiovascular Diseases', 'Nerve Compression Syndromes-cause-Pain', 'Liver Cirrhosis, Biliary-gone-End Stage Liver Disease', 'Osteoporosis-occur-Liver Cirrhosis, Biliary', 'Glucose Metabolism Disorders-enhance-Alzheimer Disease', 'Adrenal Insufficiency-enter-Aneuploidy', 'Adrenal Insufficiency-enter-Polyploidy', 'Thromboembolism-recognised-Dementia', 'Thromboembolism-recognised-Death', 'Atrial Fibrillation-recognised-Dementia', 'Atrial Fibrillation-recognised-Death', 'Arthritis, Psoriatic-include-Psoriasis', 'Atrial Fibrillation-underlie-Diabetes Mellitus', 'Atrial Fibrillation-underlie-Hypoxia', 'Atrial Fibrillation-detect-Cardiovascular Abnormalities', 'Atrial Fibrillation-underlie-Hyperthyroidism', 'Atrial Fibrillation-underlie-Heart Failure', 'Neurologic Manifestations-identified-Nervous System Diseases', 'Nervous System Diseases-observed-Genetic Diseases, Inborn', 'Nervous System Diseases-consider-Xeroderma Pigmentosum', 'Nervous System Diseases-consider-Cockayne Syndrome', 'Glomerulosclerosis, Focal Segmental-influence-Proteinuria', 'Infarction-identified-Death', 'Carcinoma, Hepatocellular-hamper-Neoplasms', 'Hepatitis C-hamper-Neoplasms', 'Trachoma-classified-Corneal Opacity', 'Epilepsy-seem-Seizures', 'Asthma-reduced-Otitis', 'Asthma-reduced-Respiratory Tract Diseases', 'Alzheimer Disease-distinguish-Brain Infarction', 'Alzheimer Disease-associated-Brain Infarction', 'Brain Infarction-associated-Alzheimer Disease', 'Dementia-distinguish-Brain Infarction', 'Dementia-associated-Brain Infarction', 'Brain Infarction-associated-Dementia', 'Brain Infarction-associated-Dementia, Vascular', 'Dementia, Vascular-associated-Brain Infarction', 'Atrial Fibrillation-underlie-Cardiovascular Diseases', 'Protoporphyria, Erythropoietic-induced-Neuroblastoma', 'Atrial Fibrillation-make-Arrhythmias, Cardiac', 'Protoporphyria, Erythropoietic-seem-Nerve Degeneration', 'Protoporphyria, Erythropoietic-induced-Astrocytoma', 'Protoporphyria, Erythropoietic-seem-Alzheimer Disease', 'Dementia-assessed-Alzheimer Disease', 'Alzheimer Disease-assessed-Cerebrovascular Disorders', 'Alzheimer Disease-share-Cerebrovascular Disorders', 'Alzheimer Disease-assessed-Cardiovascular Diseases', 'Alzheimer Disease-share-Cardiovascular Diseases', 'Dementia-biased-Alzheimer Disease', 'Stroke, Lacunar-become-Alzheimer Disease', 'Cerebral Infarction-occur-Alzheimer Disease', 'Atherosclerosis-assess-Cardiovascular Diseases', 'Atherosclerosis-prevent-Dementia', 'Alzheimer Disease-demonstrate-Brain Diseases', 'Death-attributed-Hyperparathyroidism', 'Alzheimer Disease-undergo-Melkersson-Rosenthal Syndrome', 'Dementia-assessed-Pain', 'Fractures, Bone-involve-Abnormalities, Drug-Induced', 'Fractures, Bone-involve-Dental Caries', 'Pain-collected-Death', 'Hypertension-reinforce-Weight Loss', 'Diabetes Mellitus-develop-Myocardial Infarction', 'Blindness-develop-Kidney Diseases', 'Blindness-develop-Myocardial Infarction', 'Blindness-suffer-Stroke', 'Kidney Diseases-develop-Myocardial Infarction', 'Kidney Diseases-suffer-Stroke', 'Myocardial Infarction-suffer-Stroke', 'Muscle Hypotonia-change-Microcephaly', 'Megalencephaly-turn-Microcephaly', 'Wounds and Injuries-sustain-Pelvic Neoplasms', 'Wounds and Injuries-recognize-Death', 'Pelvic Neoplasms-sustain-Death', 'Fibrosarcoma-show-Necrosis', 'Neoplasms-show-Necrosis', 'Fibrosarcoma-show-Branchio-Oto-Renal Syndrome', 'Stroke-went-Dementia', 'Infections-predispose-Urogenital Abnormalities', 'Infections-suggest-Intellectual Disability', 'Dementia-compromised-Alzheimer Disease', 'Death-caused-Respiratory Insufficiency', 'Stenosis, Pulmonary Vein-suppress-Atrial Fibrillation', 'Communicable Diseases-determine-Death', 'Pain-exclude-Fractures, Bone', 'Diabetes Mellitus-sustain-Brain Injuries, Traumatic', 'Cardiovascular Diseases-sustain-Brain Injuries, Traumatic', 'Neurogenic Inflammation-believed-Nervous System Diseases', 'Nerve Degeneration-seen-Neurodegenerative Diseases', 'Sleep Initiation and Maintenance Disorders-cope-Inflammation', 'Sleep Initiation and Maintenance Disorders-provide-Neurodegenerative Diseases', 'Restless Legs Syndrome-develop-Sleep Initiation and Maintenance Disorders', 'Restless Legs Syndrome-develop-Psychomotor Agitation', 'Restless Legs Syndrome-occur-Anemia', 'Pulmonary Disease, Chronic Obstructive-underlie-Lung Diseases', 'Drug Hypersensitivity-associated-Eosinophilia', 'Eosinophilia-associated-Drug Hypersensitivity', 'Atrial Fibrillation-reduce-Tachycardia, Atrioventricular Nodal Reentry', 'Sepsis-become-Multiple Organ Failure', 'Respiratory Distress Syndrome-become-Multiple Organ Failure', 'Tinnitus-undergo-Neuroma, Acoustic', 'Cardiovascular Diseases-reported-Cutis Laxa', 'Aortic Aneurysm-reported-Cutis Laxa', 'Stenosis, Pulmonary Artery-reported-Cutis Laxa', 'Neurodegenerative Diseases-become-Death', 'Pulmonary Emphysema-caused-Lung Diseases', 'Pulmonary Heart Disease-caused-Lung Diseases', 'Heart Failure-caused-Lung Diseases', 'Constipation-include-Neurotoxicity Syndromes', 'Nervous System Diseases-include-Neurotoxicity Syndromes', 'Hiccup-caused-Tetany', 'Dyspnea-caused-Tetany', 'Myocardial Infarction-assessed-Infarction', 'Neurodegenerative Diseases-blocked-Parkinsonian Disorders', 'Hypertension-continue-Stroke', 'Nerve Degeneration-found-Alzheimer Disease', 'Mitochondrial Diseases-contribute-Central Nervous System Diseases', 'Alzheimer Disease-contribute-Central Nervous System Diseases', 'Central Nervous System Diseases-cause-Neurodegenerative Diseases', 'Pneumococcal Infections-related-Pneumonia', 'Pneumococcal Infections-describe-Pneumonia', 'Fever-expected-Infections', 'Infarction-experience-Ischemia', 'Infarction-experience-Stroke', 'Prostatic Hyperplasia-present-Urinary Bladder Diseases', 'Hereditary Angioedema Type III-remain-Osteoporosis', 'Hereditary Angioedema Type III-remain-Cardiovascular Diseases', 'Neoplasms-tend-Carcinoma, Hepatocellular', 'Thyroiditis, Autoimmune-associate-Urticaria', 'Urticaria-associate-Thyroiditis, Autoimmune', 'Arrhythmogenic Right Ventricular Dysplasia-present-Cardiomyopathy, Dilated', 'Arrhythmogenic Right Ventricular Dysplasia-associated-Arrhythmias, Cardiac', 'Arrhythmias, Cardiac-associated-Arrhythmogenic Right Ventricular Dysplasia', 'Cardiomyopathy, Dilated-associated-Arrhythmias, Cardiac', 'Arrhythmias, Cardiac-associated-Cardiomyopathy, Dilated', 'Sepsis-occur-Death', 'Vasculitis-associated-Glomerulonephritis', 'Glomerulonephritis-associated-Vasculitis', 'Infections-include-Sepsis', 'Anemia-include-Sepsis', 'Sepsis-include-Multiple Organ Failure', 'Sepsis-manage-Multiple Organ Failure', 'Infections-manage-Multiple Organ Failure', 'Anemia-manage-Multiple Organ Failure', 'Severe Acute Respiratory Syndrome-decrease-Death', 'Cystic Fibrosis-make-Insulinoma', 'Cardiovascular Abnormalities-play-Coronary Artery Disease', 'Cardiovascular Abnormalities-play-Heart Failure', 'Cardiovascular Abnormalities-play-Death, Sudden, Cardiac', 'Cardiovascular Abnormalities-play-Ventricular Dysfunction', 'Cardiovascular Abnormalities-play-Diabetes Mellitus', 'Ventricular Fibrillation-induced-Heart Rupture', 'Malnutrition-develop-Dehydration', 'Diabetes Mellitus-compare-Metabolic Syndrome', 'Diabetes Mellitus-develop-Metabolic Syndrome', 'Infections-attack-Diabetes Mellitus', 'Arthritis-defined-Headache Disorders, Secondary', 'Arthritis-derived-Headache Disorders, Secondary', 'Dyslipidemias-associated-Kidney Diseases', 'Kidney Diseases-associated-Dyslipidemias', 'Dyslipidemias-lead-Glomerulonephritis', 'Kidney Diseases-lead-Glomerulonephritis', 'Aortic Valve Stenosis-explained-Atherosclerosis', 'Dementia-assessed-Stroke', 'Stroke-suggest-Dementia', 'Aneurysm-defined-Constriction, Pathologic', 'Renal Artery Obstruction-include-Arterial Occlusive Diseases', 'Dementia-display-Atrophy', 'Headache Disorders, Secondary-classified-Alzheimer Disease', 'Headache Disorders, Secondary-classified-Dementia, Vascular', 'Leukoencephalopathies-increase-Dementia', 'Ataxia Telangiectasia-characterized-Neurodegenerative Diseases', 'Genetic Diseases, Inborn-characterized-Neurodegenerative Diseases', 'Cerebral Arterial Diseases-related-Dementia', 'Neoplasms-enter-Leukemia', 'Osteoporosis-related-Hereditary Angioedema Type III', 'Osteoporosis-manifested-Bone Diseases, Metabolic', 'Osteoporosis-manifested-Fractures, Bone', 'Back Pain-include-Fractures, Bone', 'Fractures, Bone-trigger-Osteoporosis', 'Inflammation-culminate-Hyperplasia', 'Hypoglycemia-associated-Glucose Intolerance', 'Glucose Intolerance-associated-Hypoglycemia', 'Hypoglycemia-develop-Diabetes Mellitus', 'Glucose Intolerance-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-Glucose Intolerance', 'Glucose Intolerance-associated-Death', 'Death-associated-Glucose Intolerance', 'Glucose Intolerance-progress-Diabetes Mellitus', 'Hypoglycemia-represent-Diabetes Mellitus', 'Glucose Intolerance-differ-Death', 'Acute Kidney Injury-induced-Kidney Diseases', 'Glucose Intolerance-differ-Cardiovascular Diseases', 'Hypoglycemia-differ-Death', 'Hypoglycemia-differ-Cardiovascular Diseases', 'Drug Hypersensitivity-impair-Death', 'Diabetes Mellitus, Type 2-afflict-Glucose Intolerance', 'Neoplasms-undertreated-Chronic Pain', 'Hypotension-occur-Neurologic Manifestations', 'Chronic Pain-associated-Arthritis', 'Arthritis-associated-Chronic Pain', 'Chronic Pain-associated-Neoplasms', 'Neoplasms-associated-Chronic Pain', 'Chronic Disease-show-Death', 'Communicable Diseases-calculated-Epilepsy', 'Communicable Diseases-consult-Epilepsy', 'Epilepsy-consult-Neoplasms', 'Epilepsy-consult-Dementia', 'Epilepsy-consult-Stroke', 'Epilepsy-consult-Gastrointestinal Hemorrhage', 'Death-diagnose-Postpartum Hemorrhage', 'Bloom Syndrome-predisposed-Neoplasms', 'Death-associated-Coagulation Protein Disorders', 'Coagulation Protein Disorders-associated-Death', 'Immunologic Deficiency Syndromes-replace-Hemorrhage', 'Immunologic Deficiency Syndromes-replace-Death', 'Hemorrhage-replace-Death', 'Hemorrhage-replace-Hemophilia A', 'Death-followed-Hemophilia A', 'Death-include-Hemophilia A', 'Death-follow-Hemorrhage', 'Stroke-follow-Hemorrhage', 'Neoplasms-follow-Hemorrhage', 'Chemical and Drug Induced Liver Injury-improve-Hemophilia A', 'Nervous System Diseases-result-Death', 'Bradycardia-associated-Hypertension', 'Hypertension-associated-Bradycardia', 'Nervous System Diseases-shown-Diabetic Neuropathies', 'Diabetes Mellitus-shown-Diabetic Neuropathies', 'Weight Gain-lead-Obesity', 'Weight Gain-lead-Death', 'Atrial Fibrillation-shown-Stroke', 'Prostatic Neoplasms-cause-Death', 'Atrial Fibrillation-evaluated-Stroke', 'Kidney Diseases-correlated-Albuminuria', "Xerostomia-seen-Sjogren's Syndrome", 'Pain-occur-Autoimmune Diseases', "Fatigue-seen-Sjogren's Syndrome", 'Neuralgia-refer-Pain', 'Diabetes Mellitus-prolong-Hypothyroidism', 'Hypothyroidism-associated-Kidney Failure, Chronic', 'Kidney Failure, Chronic-associated-Hypothyroidism', 'Intracranial Aneurysm-deserve-Hyperhomocysteinemia', 'Hyperhomocysteinemia-deserve-Parkinson Disease', 'Neoplasms-associated-Hypotension', 'Hypotension-associated-Neoplasms', 'Basal Ganglia Diseases-established-Heart Diseases', 'Sinusitis-reserved-Sick Sinus Syndrome', 'Sick Sinus Syndrome-play-Syncope', 'Sick Sinus Syndrome-include-Syncope', 'Atrioventricular Block-include-Syncope', 'Cardiovascular Diseases-arise-Hypotension', 'Hypotension-seem-Syncope', 'Hip Fractures-determine-Osteoporosis', 'Encephalitis-measure-Nervous System Diseases', 'Mastitis-related-Bacterial Infections', 'Death-standardized-Neoplasms', 'Musculoskeletal Diseases-associated-Gastrointestinal Diseases', 'Gastrointestinal Diseases-associated-Musculoskeletal Diseases', 'Musculoskeletal Diseases-associated-Respiratory Tract Diseases', 'Respiratory Tract Diseases-associated-Musculoskeletal Diseases', 'Musculoskeletal Diseases-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-Musculoskeletal Diseases', 'Thrombocytosis-associated-Anemia', 'Anemia-associated-Thrombocytosis', 'Thrombocytosis-suffering-Communicable Diseases', 'Anemia-suffering-Communicable Diseases', 'Thrombocytosis-considered-Anemia', 'Anemia-considered-Communicable Diseases', 'Neoplasms-underlie-Lymphatic Diseases', 'Pain-complicated-Communication Disorders', 'Communication Disorders-lead-Pain', 'Canavan Disease-produce-Alcoholism', 'Ischemia-result-Cardiovascular Diseases', 'Intracranial Hemorrhages-result-Cardiovascular Diseases', 'Stroke-decrease-Cardiovascular Diseases', 'Lung Neoplasms-referred-Neoplasms', 'Fractures, Bone-incur-Death', 'Pancreatic Diseases-resemble-Diabetes Mellitus', 'Neutropenia-include-Bone Marrow Diseases', 'Infections-occur-Encephalitis', 'Breast Neoplasms-include-Bone Marrow Diseases', 'Infections-occur-Meningitis, Aseptic', 'Encephalitis-occur-Meningitis, Aseptic', 'Lung Neoplasms-reported-Neutropenia', 'Lymphoma, Non-Hodgkin-include-Bone Marrow Diseases', 'Lymphoma, Non-Hodgkin-include-Kidney Diseases', 'Neoplasms-include-Neutropenia', 'Death-classified-Cerebrovascular Disorders', 'Death-copy-Stroke', 'Tricuspid Valve Insufficiency-lead-Heart Failure', 'Pulmonary Valve Insufficiency-lead-Heart Failure', 'Nervous System Diseases-evaluate-Spinal Injuries', 'Weight Loss-include-Hearing Loss', 'Kidney Failure, Chronic-treated-Erectile Dysfunction', 'Erectile Dysfunction-related-Uremia', 'Erectile Dysfunction-related-Kidney Failure, Chronic', 'Erectile Dysfunction-accompany-Kidney Failure, Chronic', 'Uremia-accompany-Kidney Failure, Chronic', 'Hypernatremia-imply-Sleep Initiation and Maintenance Disorders', 'Atrophy-correlate-Vision Disorders', 'Pain-associated-Sensation Disorders', 'Sensation Disorders-associated-Pain', 'Infections-comprise-Respiratory Tract Infections', 'Pneumonia-comprise-Respiratory Tract Infections', 'Bronchitis-comprise-Respiratory Tract Infections', 'HIV Infections-address-Infections', 'Death-include-Pneumococcal Infections', 'Death-complicated-Pneumococcal Infections', 'Infections-complicated-Pneumococcal Infections', 'Neoplasms-limited-Lymphedema', 'Dermatitis-identified-Lymphangiectasis', 'Dermatitis-identified-Hemangiosarcoma', 'Sclerosis-identified-Hemangiosarcoma', 'Urogenital Abnormalities-discuss-Vulvovaginitis', 'Urogenital Abnormalities-discuss-Headache Disorders, Secondary', 'Urogenital Abnormalities-discuss-Infections', 'Urogenital Abnormalities-discuss-Urinary Incontinence', 'Urogenital Abnormalities-discuss-Sexual Dysfunction, Physiological', 'Colorectal Neoplasms-discovered-Adenomatous Polyps', 'Colorectal Neoplasms-removed-Adenoma', 'Neoplasms-removed-Adenoma', 'Angina, Unstable-include-Death', 'Arrhythmias, Cardiac-include-Death', 'Hypertension-result-Heart Failure', 'Hypertension-benefit-Coronary Artery Disease', 'Hypertension-benefit-Arrhythmias, Cardiac', 'Hypertension-benefit-Heart Failure', 'Urinary Bladder Diseases-cause-Urinary Incontinence', 'Neoplasms-increase-Neoplastic Syndromes, Hereditary', 'Wasting Syndrome-multidetermined-Anorexia', 'Anorexia-multidetermined-Cachexia', 'Anorexia-termed-Cachexia', 'Anorexia-multidetermined-Neoplasms', 'Anorexia-induced-Neoplasms', 'Wasting Syndrome-termed-Cachexia', 'Wasting Syndrome-induced-Neoplasms', 'Cachexia-induced-Neoplasms', 'Peptic Ulcer-show-Infections', 'Infections-protect-Peptic Ulcer', 'Encephalitis, Tick-Borne-present-Meningitis', 'Encephalitis, Tick-Borne-present-Meningoencephalitis', 'Stroke-cause-Dementia, Vascular', 'Death-cause-Parkinson Disease, Secondary', 'Parkinson Disease-find-Craniocerebral Trauma', 'Craniocerebral Trauma-trigger-Parkinsonian Disorders', 'Death-occur-Esophageal Neoplasms', 'Vision Disorders-associated-Osteonecrosis', 'Osteonecrosis-associated-Vision Disorders', 'Bone Neoplasms-contribute-Immunologic Deficiency Syndromes', 'Heart Failure-include-Cardiac Complexes, Premature', 'Fibrosis-study-Carcinoma, Hepatocellular', 'Death-calculate-Infections', 'Bronchitis-associated-Infections', 'Infections-associated-Bronchitis', 'Infections-include-Meningitis, Bacterial', 'Infections-include-Endocarditis', 'Infections-include-Hypertension', 'Infections-include-Arthritis, Infectious', 'Melioidosis-present-Prostatitis', 'Hip Fractures-assessed-Occupational Injuries', 'Obesity-improve-Weight Loss', 'Osteoarthritis-improve-Weight Loss', 'Cataract-investigate-Death', 'Adrenal Insufficiency-contribute-Meibomian Gland Dysfunction', 'Adrenal Insufficiency-contribute-Dry Eye Syndromes', 'Tachycardia, Supraventricular-improve-Death', 'Tachycardia-associated-Stroke', 'Stroke-associated-Tachycardia', 'Thrombocytopenia-include-Drug-Related Side Effects and Adverse Reactions', 'Leukopenia-include-Drug-Related Side Effects and Adverse Reactions', 'Pancytopenia-include-Drug-Related Side Effects and Adverse Reactions', 'Agranulocytosis-include-Drug-Related Side Effects and Adverse Reactions', 'Anemia, Aplastic-include-Drug-Related Side Effects and Adverse Reactions', 'Acute Kidney Injury-include-Drug-Related Side Effects and Adverse Reactions', 'Disseminated Intravascular Coagulation-include-Drug-Related Side Effects and Adverse Reactions', 'Epilepsy, Temporal Lobe-cause-Memory Disorders', 'Death-associated-Brain Infarction', 'Brain Infarction-associated-Death', 'Alzheimer Disease-precede-Nerve Degeneration', 'Alzheimer Disease-include-Cerebral Hemorrhage', 'Alzheimer Disease-cause-Cerebral Hemorrhage', 'Ischemia-include-Alzheimer Disease', 'Infarction-include-Alzheimer Disease', 'Malformations of Cortical Development-include-Alzheimer Disease', 'Leukoencephalopathies-include-Alzheimer Disease', 'Hemorrhage-include-Alzheimer Disease', 'Infarction-influence-Dementia', 'Drug Hypersensitivity-represented-Neurogenic Inflammation', 'Muscular Diseases-explained-Kyphosis', 'Muscular Diseases-explained-Nervous System Diseases', 'Thrombocytopenia-associated-Drug-Related Side Effects and Adverse Reactions', 'Drug-Related Side Effects and Adverse Reactions-associated-Thrombocytopenia', 'Death, Sudden-cause-Torsades de Pointes', 'Arrhythmias, Cardiac-coexist-Long QT Syndrome', 'Arrhythmias, Cardiac-coexist-Heart Failure', 'Arrhythmias, Cardiac-coexist-Bradycardia', 'Arrhythmias, Cardiac-coexist-Drug Overdose', 'Arrhythmias, Cardiac-coexist-Liver Diseases', 'Long QT Syndrome-coexist-Heart Failure', 'Long QT Syndrome-coexist-Bradycardia', 'Carcinoma, Acinar Cell-increase-Death', 'Long QT Syndrome-coexist-Liver Diseases', 'Infections-lead-Gastritis, Atrophic', 'Syncope-mediate-End Stage Liver Disease', 'Syncope-result-End Stage Liver Disease', 'Infections-progress-Stomach Neoplasms', 'Infections-reverse-Stomach Neoplasms', 'Pain-increase-Arthritis, Rheumatoid', 'Osteoarthritis-found-Arthritis, Rheumatoid', 'Pain-decrease-Arthritis, Rheumatoid', 'Arthritis, Rheumatoid-decrease-Osteoarthritis', 'Pain-focus-Arthritis, Rheumatoid', 'Pain-focus-Osteoarthritis', 'Peptic Ulcer-based-Ulcer', 'Atrial Fibrillation-associated-Heart Valve Diseases', 'Heart Valve Diseases-associated-Atrial Fibrillation', 'Coronary Artery Disease-include-Heart Diseases', 'Hypertension-include-Heart Diseases', 'Atrial Fibrillation-occur-Heart Valve Diseases', 'Atrial Fibrillation-ruled-Thyrotoxicosis', 'Heart Diseases-present-Atrial Fibrillation', 'Atrial Fibrillation-include-Hypertrophy, Left Ventricular', 'Alzheimer Disease-cause-Respiratory Distress Syndrome', 'Infections-present-Erythema', 'Infections-present-Ulcer', 'Cellulitis-distinguished-Erysipelas', 'Cellulitis-distinguished-Fasciitis', 'Stroke-account-Infarction, Posterior Cerebral Artery', 'Hypertension-demonstrate-Stroke', 'Hypertension-demonstrate-Cardiovascular Diseases', 'Death-treated-Parkinson Disease', 'Death-treated-Huntington Disease', 'Williams Syndrome-mistreated-Dementia', 'Bradycardia-reported-Hypotension', 'Bradycardia-reported-Exanthema', 'Neurologic Manifestations-caused-Fatigue', 'Gait Disorders, Neurologic-worsen-Muscle Rigidity', 'Vision Disorders-categorised-Vision, Low', 'Vision Disorders-categorised-Blindness', 'Cardiovascular Diseases-reduced-Hypertrophy, Left Ventricular', 'Prostatic Neoplasms-detected-Neoplasms', 'Alzheimer Disease-undergo-Sleep Wake Disorders', 'Stroke-sleepier-Alzheimer Disease', 'Stroke-occur-Infarction', 'Infarction-occur-Hypothalamic Neoplasms', 'Neoplasms-experience-Fatigue', 'Anemia-lead-Muscle Weakness', 'Diabetes Mellitus-created-Fistula', 'Hypertension-occur-Death', 'Atherosclerosis-followed-Inflammation', 'Infections-include-Cardiomyopathies', 'Cardiomyopathies-include-Inflammation', 'Cardiomyopathies-result-Inflammation', 'Mastocytosis, Systemic-result-Fractures, Bone', 'Venous Thromboembolism-remain-Death', 'Chronic Disease-employ-Death', 'Neoplasms-compare-Obesity', 'Chronic Disease-suffer-Joint Diseases', 'Fractures, Bone-develop-Pain', 'Hearing Loss-hear-Hypertension', 'Coronary Artery Disease-hear-Hypertension', 'Acquired Immunodeficiency Syndrome-include-Communicable Diseases', 'Chronic Disease-include-Communicable Diseases', 'Immunologic Deficiency Syndromes-cause-Chronic Disease', 'Cardiovascular Diseases-contribute-Bone Diseases, Metabolic', 'Immunologic Deficiency Syndromes-result-Lysosomal Storage Diseases', 'Fallopian Tube Diseases-contribute-Bone Diseases, Metabolic', 'Immunologic Deficiency Syndromes-result-Neuronal Ceroid-Lipofuscinoses', 'Bone Diseases, Metabolic-contribute-Chronic Disease', 'Fractures, Bone-increase-Chronic Disease', 'Turner Syndrome-accounted-Cardiovascular Diseases', 'Turner Syndrome-linked-Deafness', 'Pancreatitis-caused-Genetic Diseases, Inborn', 'Genetic Diseases, Inborn-cause-Pancreatic Neoplasms', 'Genetic Diseases, Inborn-underlie-Pancreatic Neoplasms', 'Turner Syndrome-show-Otitis', 'Death-identify-Coronary Artery Disease', 'Heart Diseases-include-Acute Disease', 'Dwarfism, Pituitary-elucidate-Cardiovascular Diseases', 'Prostatic Neoplasms-diagnose-Erectile Dysfunction', 'Central Nervous System Neoplasms-regarded-Brain Neoplasms', 'Ulcer-covered-Tibial Meniscus Injuries', 'Lung Neoplasms-fit-Neutropenia', 'Lung Neoplasms-fit-Fatigue', 'Colitis-make-Cross Infection', 'Infections-seen-Enterocolitis, Pseudomembranous', 'Chemical and Drug Induced Liver Injury-diagnosed-Liver Failure', 'Neurotoxicity Syndromes-induced-Amino Acid Metabolism, Inborn Errors', 'Drug-Related Side Effects and Adverse Reactions-induced-Amino Acid Metabolism, Inborn Errors', 'Diabetes Mellitus-evolve-Cystic Fibrosis', 'Cystic Fibrosis-associated-Death', 'Death-associated-Cystic Fibrosis', 'Cystic Fibrosis-compare-Death', 'Hypoxia-contribute-Inflammation', 'Osteoporosis-maintain-Hepatitis E', 'Infections-cause-Pain', 'Onychomycosis-undermine-Diabetes Mellitus', 'Diabetes Mellitus-found-Carotid Stenosis', 'Arteriovenous Fistula-examined-Kidney Failure, Chronic', 'Arteriovenous Fistula-determined-Heart Failure', 'Arteriovenous Fistula-determined-Diabetes Mellitus', 'Airway Obstruction-increase-Asthma', 'Asthma-worsen-Osteoporosis', 'Asthma-worsen-Eye Diseases', 'Asthma-used-Arrhythmias, Cardiac', 'Pulmonary Disease, Chronic Obstructive-evaluated-Airway Obstruction', 'Hypogonadism-increase-Hyperparathyroidism', 'Hypogonadism-increase-Malabsorption Syndromes', 'Hypogonadism-contribute-Hip Fractures', 'Hyperparathyroidism-increase-Malabsorption Syndromes', 'Malabsorption Syndromes-predispose-Hip Fractures', 'Neoplasms-ruled-Coinfection', 'Breast Neoplasms-ruled-Coinfection', 'Cholangitis, Sclerosing-relieve-Sepsis', 'Porencephaly-increased-Erectile Dysfunction', 'Hyperlipidemias-increased-Erectile Dysfunction', 'Fractures, Bone-increased-Erectile Dysfunction', 'Neoplasms-present-Adenoma', 'Vitiligo-develop-Skin Neoplasms', 'Thrombosis-known-Antiphospholipid Syndrome', 'Thrombosis-known-Lupus Erythematosus, Systemic', 'Thrombosis-correlated-Lymphoma, Non-Hodgkin', 'Lymphoma-remain-Thrombosis', 'Lymphoma-remain-Lymphoma, Non-Hodgkin', 'Pneumococcal Infections-considered-Arthritis', 'Arthritis-complicate-Pneumococcal Infections', 'Pneumococcal Infections-considered-Infections', 'Arthritis-complicate-Respiratory Tract Infections', 'Diabetes Mellitus-incur-Staphylococcal Scalded Skin Syndrome', 'Diabetes Mellitus-incur-Myotonic Dystrophy', 'Dementia-hospitalized-Psychoses, Substance-Induced', 'Dyslipidemias-recognized-Atherosclerosis', 'Heart Failure-include-Arrhythmias, Cardiac', 'Fractures, Bone-occur-Diabetes Mellitus', 'Death, Sudden-include-Heart Failure', 'Seizures-represent-Epilepsy', 'Diabetes Mellitus-stratify-Diabetes Mellitus, Type 2', 'Fistula-stratify-Diabetes Mellitus, Type 2', 'Delirium-affect-Death', 'Atrophy-diagnosed-Muscular Diseases', 'Death-related-Myocardial Infarction', 'Acquired Immunodeficiency Syndrome-protect-HIV Infections', 'Death-implicated-Osteoarthritis', 'Shock, Septic-identified-Death', 'Headache Disorders, Secondary-seem-Gastrointestinal Diseases', 'Ischemia-involve-Thrombosis', 'Pneumonia-linked-Death', 'Meningitis-linked-Death', 'Seizures-predict-Coronary Artery Disease', 'Stroke-assessed-Dementia', 'Drug-Related Side Effects and Adverse Reactions-associated-Dementia', 'Dementia-associated-Drug-Related Side Effects and Adverse Reactions', 'Xerostomia-predict-Headache Disorders, Secondary', 'Torsades de Pointes-predisposed-Cardiovascular Diseases', 'Death, Sudden-predisposed-Cardiovascular Diseases', 'Pain, Postoperative-associated-Death', 'Death-associated-Pain, Postoperative', 'Death-undergo-Airway Obstruction', 'Neoplasms-occur-Carcinoma, Merkel Cell', 'Neoplasms-distinguish-Melanoma', 'Cerebrovascular Disorders-undergo-Constriction, Pathologic', 'Neoplasms-distinguish-Lymphoma', 'Choroiditis-manifest-Hemorrhage', 'Immunologic Deficiency Syndromes-result-Pituitary Diseases', 'Immunologic Deficiency Syndromes-result-HIV Infections', 'Immunologic Deficiency Syndromes-result-Primary Ovarian Insufficiency', 'Immunologic Deficiency Syndromes-result-Turner Syndrome', 'Cerebrovascular Disorders-visualise-Infarction', 'Neutropenia-lead-Sepsis', 'Fractures, Bone-elevated-Musculoskeletal Pain', 'Fractures, Bone-elevated-Pain', 'Tetany-evaluate-Ulcer', 'Tetany-included-Skin Ulcer', 'Pneumonia-occur-Infections', 'Death-prevented-Hyperparathyroidism', "Legionnaires' Disease-raise-Critical Illness", 'Hyponatremia-associated-Pituitary Neoplasms', 'Pituitary Neoplasms-associated-Hyponatremia', 'Hyponatremia-show-Consciousness Disorders', 'Pituitary Diseases-cause-Adrenal Insufficiency', 'Consciousness Disorders-show-Hemorrhage', 'Pancreatitis, Chronic-characterized-Exocrine Pancreatic Insufficiency', 'Pancreatitis, Chronic-characterized-Pain', 'Diarrhea-prevent-Hypotension', 'Diarrhea-prevent-Multiple Organ Failure', 'Pancreatitis-related-Gallstones', 'Inflammatory Bowel Diseases-confused-Diverticulitis', 'Inflammatory Bowel Diseases-treated-Drug-Related Side Effects and Adverse Reactions', 'Inflammation-result-Fibrosis', 'Deglutition Disorders-related-Esophageal Stenosis', 'Vision Disorders-associated-Epilepsy', 'Epilepsy-associated-Vision Disorders', 'Stroke-work-Memory Disorders', 'Dermatitis, Atopic-show-Hypertension', 'Asthma-cured-Infections', 'Infections-seem-Ichthyosis, X-Linked', 'Arthritis-associated-Fractures, Bone', 'Fractures, Bone-associated-Arthritis', 'Urinary Incontinence-associated-Fractures, Bone', 'Fractures, Bone-associated-Urinary Incontinence', 'Sleep Wake Disorders-based-Apnea', 'Sleep Wake Disorders-based-Sleep Apnea Syndromes', 'Sleep Wake Disorders-based-Sleep Apnea, Obstructive', 'Obesity-identify-Sleep Wake Disorders', 'Respiratory Distress Syndrome-accompany-Erectile Dysfunction', 'Death-deteriorate-Infections', 'Death-deteriorate-Malnutrition', 'Death-manifest-Heart Failure, Diastolic', 'Cardiovascular Abnormalities-target-Tachycardia', 'Arbovirus Infections-lose-Pneumonia', 'Prostatic Hyperplasia-linked-Prostatic Neoplasms', 'Cataract-include-Myopia', 'Skin Diseases-associated-Liver Failure', 'Liver Failure-associated-Skin Diseases', 'Calcinosis-correlated-Coronary Artery Disease', 'Atherosclerosis-vary-Coronary Artery Disease', 'Necrosis-bear-Adenocarcinoma', 'Alzheimer Disease-enhance-Dementia', 'Macular Edema-include-Fractures, Spontaneous', 'Endometrial Neoplasms-characterised-Adrenal Insufficiency', 'Babesiosis-enhance-Infections', 'Leishmaniasis-enhance-Infections', "Sjogren's Syndrome-associated-Salivary Gland Diseases", "Salivary Gland Diseases-associated-Sjogren's Syndrome", 'Autoimmune Diseases-associated-Salivary Gland Diseases', 'Salivary Gland Diseases-associated-Autoimmune Diseases', 'Neurologic Manifestations-associated-Cerebral Hemorrhage', 'Cerebral Hemorrhage-associated-Neurologic Manifestations', 'Periodontal Diseases-control-Diabetes Mellitus', 'Inflammatory Bowel Diseases-characterized-Crohn Disease', 'Polyneuropathies-define-Headache Disorders, Secondary', 'Ketosis-characterised-Diabetes Mellitus', 'Cardiovascular Diseases-remain-Breast Neoplasms', 'Obesity-affect-Neoplasms', 'Dementia-performed-Death', 'Infections-reduce-Wounds and Injuries', 'Stroke-exclude-Subarachnoid Hemorrhage', 'Hyperglycemia-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-Hyperglycemia', 'Cardiomyopathy, Dilated-develop-Acidosis', 'Hypothalamic Neoplasms-induce-Sleep Wake Disorders', 'Colorectal Neoplasms-proven-Adenoma', 'Colorectal Neoplasms-proven-Adenocarcinoma', 'Neoplasms-occur-Delirium', 'Neoplasms-occur-Hereditary Breast and Ovarian Cancer Syndrome', 'Escherichia coli Infections-contribute-Respiratory Tract Infections', 'Central Nervous System Venous Angioma-present-Neuralgia', 'Death-considered-Hypertrophy, Left Ventricular', 'Death-considered-Coronary Artery Disease', 'Death-seen-Heart Failure', 'Neoplasms-survive-Myelodysplastic Syndromes', 'Myelodysplastic Syndromes-undergo-Vulvar Neoplasms', 'Restless Legs Syndrome-cause-Sleep Wake Disorders', 'Restless Legs Syndrome-cause-Sleepiness', 'Restless Legs Syndrome-include-Paresthesia', 'Diabetes Mellitus-combined-Coronary Artery Disease', 'Carcinogenesis-induce-Drug-Related Side Effects and Adverse Reactions', 'Death-live-Neoplasms', 'Fractures, Bone-involve-Obesity', 'Parkinson Disease-characterized-Gait Disorders, Neurologic', 'Neurodegenerative Diseases-characterized-Gait Disorders, Neurologic', 'Pain-compared-Diabetes Mellitus', 'Hypesthesia-compared-Diabetes Mellitus', 'Edema-compared-Diabetes Mellitus', 'Neuralgia-associated-Dementia', 'Dementia-associated-Neuralgia', 'Polycystic Ovary Syndrome-show-Ovarian Neoplasms', 'Arthritis, Rheumatoid-seek-Chronic Pain', 'Dementia-collect-Death', 'Parkinson Disease, Secondary-defined-Hypokinesia', 'Parkinson Disease, Secondary-defined-Tremor', 'Parkinson Disease, Secondary-defined-Muscle Rigidity', 'Gait Disorders, Neurologic-associated-Parkinsonian Disorders', 'Parkinsonian Disorders-associated-Gait Disorders, Neurologic', 'Chronic Disease-associated-Hearing Loss', 'Hearing Loss-associated-Chronic Disease', 'Death-estimated-Weight Loss', 'Death-estimated-Weight Gain', 'Aortic Valve Stenosis-suffer-Werner Syndrome', 'Aortic Valve Stenosis-suffer-Liver Cirrhosis', 'Infections-identify-Acquired Immunodeficiency Syndrome', 'Cardiomyopathy, Hypertrophic-relate-Death, Sudden', 'Cardiomyopathy, Hypertrophic-confer-Death', 'Dyspnea-associated-Airway Obstruction', 'Airway Obstruction-associated-Dyspnea', 'Neoplasms-include-Liver Diseases', 'Hypercholesterolemia-identify-Coronary Artery Disease', 'Osteoporotic Fractures-demonstrate-Death', 'Death-expect-Fractures, Bone', 'Bone Diseases-characterised-Osteolysis', 'Hypertension-accompany-Cardiomyopathy, Hypertrophic', 'Cardiovascular Diseases-eliminate-Stroke', 'Myocardial Infarction-impose-Diabetes Mellitus', 'Diabetes Mellitus-impose-Heart Failure', 'Diabetes Mellitus-impose-Death', 'Diabetes Mellitus-avoid-Cardiovascular Diseases', 'Dyslipidemias-remain-Coronary Artery Disease', 'Glucose Intolerance-remain-Coronary Artery Disease', 'Diabetes Mellitus-eliminate-Coronary Artery Disease', 'Obesity-remain-Coronary Artery Disease', 'Hypertension-recognized-Coronary Artery Disease', 'Fatigue-withstand-Osteoarthritis', 'Bronchitis-known-Pulmonary Disease, Chronic Obstructive', 'Pulmonary Disease, Chronic Obstructive-prevent-Pneumococcal Infections', 'Death-decrease-Pulmonary Disease, Chronic Obstructive', 'Pancreatitis-affect-Neoplasms', 'Stomach Neoplasms-affect-Neoplasms', 'Superior Vena Cava Syndrome-induced-Neoplasms', 'Pneumococcal Infections-decrease-Tuberculosis, Multidrug-Resistant', 'Erythema-occur-Hyperpigmentation', 'Parkinson Disease-programme-Stroke', 'Urinary Incontinence-associated-Malformations of Cortical Development', 'Malformations of Cortical Development-associated-Urinary Incontinence', 'Urinary Bladder Diseases-associated-Malformations of Cortical Development', 'Malformations of Cortical Development-associated-Urinary Bladder Diseases', 'Myalgia-associated-Rheumatic Diseases', 'Rheumatic Diseases-associated-Myalgia', 'Myalgia-associated-Polymyalgia Rheumatica', 'Polymyalgia Rheumatica-associated-Myalgia', 'Polymyalgia Rheumatica-include-Rheumatic Diseases', 'Polymyalgia Rheumatica-lead-Arteritis', 'Polymyalgia Rheumatica-lead-Blindness', 'Polymyalgia Rheumatica-lead-Stroke', 'Arteritis-lead-Blindness', 'Arteritis-lead-Stroke', 'Constriction, Pathologic-decrease-Arteriovenous Fistula', 'Cardiovascular Diseases-associated-Hypothalamic Neoplasms', 'Hypothalamic Neoplasms-associated-Cardiovascular Diseases', 'Diabetes Mellitus, Type 2-associated-Hypothalamic Neoplasms', 'Hypothalamic Neoplasms-associated-Diabetes Mellitus, Type 2', 'Breast Neoplasms, Male-decline-Impotence, Vasculogenic', 'Inflammation-pointed-Heart Diseases', 'Inflammation-pointed-Alzheimer Disease', 'Inflammation-pointed-Neoplasms', 'Neurodegenerative Diseases-discriminate-Alzheimer Disease', 'Alzheimer Disease-discriminate-Dementia, Vascular', 'Neoplasms-reduce-Neurodegenerative Diseases', 'Hereditary Breast and Ovarian Cancer Syndrome-characterized-Fatigue', 'Hereditary Breast and Ovarian Cancer Syndrome-characterized-Osteoporosis', 'Hereditary Breast and Ovarian Cancer Syndrome-characterized-Obesity', 'Ischemia-associated-Fibrosis', 'Fibrosis-associated-Ischemia', 'Aneurysm-thought-Erectile Dysfunction', 'Aneurysm-thought-Death', 'Hemorrhage-increase-Wounds and Injuries', 'Hemorrhage-increase-Hypertension', 'Neoplasms-occur-Endometrial Neoplasms', 'Heart Failure-affect-Hypertension', 'Heart Failure-affect-Myocardial Infarction', 'Heart Failure, Diastolic-managed-Ischemia', 'Wounds and Injuries-cause-Atrophy', 'Wounds and Injuries-cause-Memory Disorders', 'Atrophy-related-Memory Disorders', 'Pupil Disorders-measure-Alzheimer Disease', 'Hip Fractures-followed-Stroke', 'Acne Vulgaris-include-Acrocephalosyndactylia', 'Rosacea-include-Acrocephalosyndactylia', 'Dermatitis, Irritant-include-Acrocephalosyndactylia', 'Dermatitis, Atopic-include-Acrocephalosyndactylia', 'Psoriasis-include-Acrocephalosyndactylia', 'Xerostomia-include-Acrocephalosyndactylia', 'Hemophilia A-affect-Autoimmune Diseases', 'Blood Coagulation Disorders-affect-Autoimmune Diseases', 'Glaucoma, Open-Angle-associated-Vision Disorders', 'Vision Disorders-associated-Glaucoma, Open-Angle', 'Optic Neuropathy, Ischemic-associated-Vision Disorders', 'Vision Disorders-associated-Optic Neuropathy, Ischemic', 'Optic Atrophy-associated-Vision Disorders', 'Vision Disorders-associated-Optic Atrophy', 'Stroke-experience-Seizures', 'Seizures-associated-Cerebrovascular Disorders', 'Cerebrovascular Disorders-associated-Seizures', 'Neoplasms-predict-Abnormalities, Drug-Induced', 'Stroke-predict-Diabetes Mellitus', 'Myocardial Infarction-predict-Death', 'Myocardial Infarction-predict-Diabetes Mellitus', 'Death-predict-Diabetes Mellitus', 'Neoplasms-develop-Neoplasm Metastasis', 'Ataxia-show-Aneuploidy', 'Death-range-Dementia', 'Fractures, Bone-occur-Fractures, Spontaneous', 'Brain Injuries-include-Heredodegenerative Disorders, Nervous System', 'Delirium-include-Heredodegenerative Disorders, Nervous System', 'Sleep Wake Disorders-include-Heredodegenerative Disorders, Nervous System', 'Brain Injuries-include-Alzheimer Disease', 'Delirium-include-Alzheimer Disease', 'Sleep Wake Disorders-include-Alzheimer Disease', 'Colonic Neoplasms-expressed-Pancreatitis', 'Coronary Artery Disease-improve-Myocardial Infarction', 'Angina Pectoris-improve-Myocardial Infarction', 'Asthma-remain-Pulmonary Disease, Chronic Obstructive', 'Hypotension, Orthostatic-hospitalized-Heart Failure', 'Hypotension, Orthostatic-detected-Heart Failure', 'Heart Failure-develop-Tachycardia', 'Tachycardia-develop-Hypotension', 'Obesity-reduce-Osteoporosis', 'Cardiac Output, Low-contribute-Death', 'Heart Arrest-considered-Death', 'Respiratory Insufficiency-contribute-Death', 'Heart Arrest-considered-Atherosclerosis', 'Central Nervous System Diseases-contribute-Death', 'Heart Failure-develop-Death', 'Hip Fractures-compare-Osteoporotic Fractures', 'Alzheimer Disease-include-Adrenal Insufficiency', 'Heart Diseases-account-Cardiomyopathy, Hypertrophic', 'Cerebral Infarction-regard-Stroke', 'Cerebral Infarction-regard-Embolism', 'Cerebral Infarction-regard-Ischemia', 'Ischemia-regard-Stroke', 'Ischemia-regard-Embolism', 'Liver Diseases-apply-Carcinoma, Hepatocellular', 'Stomach Neoplasms-associated-Gastritis', 'Gastritis-associated-Stomach Neoplasms', 'Delirium-result-Psychoses, Substance-Induced', 'Neoplasms-thought-Colorectal Neoplasms', 'Cardiomyopathies-develop-Ventricular Dysfunction', 'Infections-develop-Anemia, Hemolytic', 'Infections-include-Lymphadenitis', 'Infections-include-Cholangitis', 'Infections-include-Mastitis', 'Infections-include-Prostatitis', 'Infections-include-Shock, Septic', 'Hypertension-increase-Aneurysm', 'Atrophy-include-Depression, Postpartum', 'Fetal Growth Retardation-increase-Diabetes Mellitus', 'Stroke-constructed-Atrial Fibrillation', 'Stroke-constructed-Cardiomyopathy, Hypertrophic', 'Coronary Occlusion-lower-Ischemia', 'Death-validate-Neoplasms', 'Coronary Occlusion-assessed-Chest Pain', 'Ischemia-assessed-Chest Pain', 'Chronic Disease-approach-Death', 'Diabetes Mellitus-deplete-Hyperglycemia', 'Death-belong-Hypertension', 'Hypertension-associated-Hyperglycemia', 'Hyperglycemia-associated-Hypertension', 'Hypertension-associated-Hypertriglyceridemia', 'Hypertriglyceridemia-associated-Hypertension', 'Aneurysm-include-Glomerulonephritis', 'Glomerulonephritis-explained-Aneurysm', 'Hypertension-explained-Aneurysm', 'Liver Diseases-maintain-Pain', 'Testicular Neoplasms-represent-Neoplasms', 'Seminoma-defined-Carcinoma, Embryonal', 'Seminoma-defined-Endodermal Sinus Tumor', 'Seminoma-defined-Choriocarcinoma', 'Seminoma-defined-Teratoma', 'Seminoma-defined-Neoplasms', 'Neoplasms-overcome-Death', 'Anorexia-become-Malnutrition', 'Fractures, Bone-offer-Breast Neoplasms', 'Osteoporosis-offer-Breast Neoplasms', 'Alzheimer Disease-result-Memory Disorders', 'Brain Diseases-result-Memory Disorders', 'Death-account-Cerebral Hemorrhage', 'Sick Sinus Syndrome-appear-Long QT Syndrome', 'Sick Sinus Syndrome-reported-Drug Overdose', 'Long QT Syndrome-seen-Drug Overdose', 'Osteoporosis-associated-Tooth Loss', 'Tooth Loss-associated-Osteoporosis', 'Alveolar Bone Loss-associated-Tooth Loss', 'Tooth Loss-associated-Alveolar Bone Loss', 'Pituitary Neoplasms-occur-Perceptual Disorders', 'Lung Diseases-identified-Arthritis, Rheumatoid', 'Lung Diseases-meet-Heart Failure, Diastolic', 'Pulmonary Edema-associated-Hypertension', 'Hypertension-associated-Pulmonary Edema', 'Death-appear-Heart Failure, Diastolic', 'Death-appear-Heart Failure, Systolic', 'Death-exceed-Heart Failure, Systolic', 'Heart Failure, Diastolic-exceed-Heart Failure, Systolic', 'Cardiovascular Diseases-lead-Heart Failure', 'Thyroid Neoplasms-differentiate-Neoplasms', 'Cardiomyopathy, Hypertrophic-lead-Death', 'Cardiomyopathy, Hypertrophic-occur-Atrial Fibrillation', 'Takotsubo Cardiomyopathy-considered-Mitral Valve Stenosis', 'Mitral Valve Stenosis-undergo-Takotsubo Cardiomyopathy', 'Meniere Disease-mimic-Stroke', 'Congenital Hypothyroidism-exist-Hypothyroidism', 'Congenital Hypothyroidism-exist-Thyroid Diseases', 'Congenital Hypothyroidism-lead-Thyroid Diseases', 'Arterial Occlusive Diseases-result-Ischemia', 'Myalgia-progress-Ischemia', 'Myalgia-result-Limb Deformities, Congenital', 'Ischemia-result-Limb Deformities, Congenital', 'Asthma-appear-Pulmonary Disease, Chronic Obstructive', 'Pulmonary Disease, Chronic Obstructive-affect-Chest Pain', 'Drug Hypersensitivity-distinguished-Pruritus', 'Drug Hypersensitivity-develop-Dermatitis', 'Drug Hypersensitivity-distinguished-Mastocytosis, Systemic', 'Drug Hypersensitivity-distinguished-Skin Diseases, Vesiculobullous', 'Drug Hypersensitivity-treat-Varicose Ulcer', 'Drug Hypersensitivity-treat-Eye Diseases', 'Varicose Ulcer-treat-Eye Diseases', 'Obesity-result-Weight Gain', 'Arthritis, Rheumatoid-predispose-Gastrointestinal Diseases', 'Nervous System Diseases-eliminate-Urinary Incontinence', 'Urinary Incontinence, Urge-associated-Nervous System Diseases', 'Nervous System Diseases-associated-Urinary Incontinence, Urge', 'Bone Neoplasms-account-Fractures, Bone', 'Urinary Bladder, Overactive-treat-Renal Insufficiency', 'Fractures, Bone-represent-Osteoporotic Fractures', 'Peripheral Nervous System Diseases-explain-Diabetes Mellitus', 'Nervous System Diseases-explain-Diabetes Mellitus', 'Dermatitis-follow-Mycoses', 'Dermatitis-follow-Arbovirus Infections', 'Prostatitis-cause-Airway Obstruction', 'Prostatitis-cause-Urinary Tract Infections', 'Common Cold-show-Pruritus', 'Acquired Immunodeficiency Syndrome-increase-Lung Neoplasms', 'Neoplasms-presented-Sarcoma, Kaposi', 'Neoplasms-presented-Lung Neoplasms', 'Parkinson Disease-reduce-Stroke', 'Genetic Diseases, Inborn-include-Hematologic Neoplasms', 'Cardiac Output, High-coexist-Bone Diseases, Metabolic', 'Cardiac Output, High-make-Fractures, Bone', 'Bone Diseases, Metabolic-make-Fractures, Bone', 'Neurodegenerative Diseases-exemplified-Xeroderma Pigmentosum', 'Carcinogenesis-minimize-Neurodegenerative Diseases', 'Alzheimer Disease-experience-Memory Disorders', 'Weight Loss-directed-Obesity', 'Neoplasms-involved-Death', 'Heart Failure-caused-Heart Diseases', 'Neoplasms-involved-Colorectal Neoplasms', 'Muscle Weakness-occur-Deglutition Disorders', 'Diabetes Mellitus-account-Nervous System Diseases', 'Asthma-include-Airway Obstruction', 'Asthma-include-Sleep Wake Disorders', 'Asthma-include-Cough', 'Asthma-include-Emphysema', 'Venous Thrombosis-undergo-Colorectal Neoplasms', 'Pneumonia-mimic-Heart Arrest', 'Heart Arrest-associated-Pneumonia', 'Pneumonia-associated-Heart Arrest', 'Neuralgia-become-Diabetes Mellitus', 'Arbovirus Infections-warranted-Carcinoma, Hepatocellular', 'Hyperhomocysteinemia-implicate-Atherosclerosis', 'Hyperhomocysteinemia-characterize-Atherosclerosis', 'Neoplasms-ruled-Breast Neoplasms', 'Neurodegenerative Diseases-characterise-Alzheimer Disease', 'Hypogonadism-considered-Osteoporosis', 'Inflammation-lead-Anorexia', 'Hypogonadism-occur-Fractures, Bone', 'Hypogonadism-occur-Hip Fractures', 'Wounds and Injuries-result-Intracranial Hemorrhages', 'Craniocerebral Trauma-produce-Intracranial Hemorrhages', 'Wounds and Injuries-produce-Intracranial Hemorrhages', 'Taste Disorders-involved-Pain', 'Sleep Initiation and Maintenance Disorders-read-Blindness', 'Neoplasms-result-Postoperative Complications', 'Cachexia-cause-Death', 'Intestinal Diseases-cause-Death', 'Carcinoma, Non-Small-Cell Lung-reduce-Headache Disorders, Secondary', 'Colonic Neoplasms-recorded-Neoplasms', 'Fractures, Bone-use-Osteoporotic Fractures', 'Diabetes Mellitus-lowered-Renal Insufficiency', 'Renal Insufficiency-lowered-Proteinuria', 'Osteoporosis-occur-Hypogonadism', 'Eunuchism-associated-Bone Neoplasms', 'Bone Neoplasms-associated-Eunuchism', 'Leprosy-classified-Osteoporosis', 'Eunuchism-associated-Fractures, Bone', 'Fractures, Bone-associated-Eunuchism', 'Osteoarthritis-classified-Pain', 'Lymphoma, Non-Hodgkin-diagnosed-Lymphoma', 'Protein S Deficiency-contribute-Osteoporotic Fractures', 'Weight Loss-reduce-Arthritis', 'Weight Loss-reduce-Diabetes Mellitus', 'Chemical and Drug Induced Liver Injury-found-Biliary Atresia', 'Chemical and Drug Induced Liver Injury-induce-Liver Failure', 'Biliary Atresia-induce-Liver Failure', 'Fever-associated-Inflammation', 'Inflammation-associated-Fever', 'Knee Injuries-include-Osteoarthritis', 'Pain-associated-Neuromuscular Diseases', 'Neuromuscular Diseases-associated-Pain', 'Pain-associated-Headache', 'Headache-associated-Pain', 'Inflammation-associated-Headache', 'Headache-associated-Inflammation', 'Death-contribute-Fractures, Bone', 'Diabetes Mellitus-reduce-Dementia', 'Urinary Incontinence-achieve-Headache Disorders, Secondary', 'Atrophy-found-Dementia', 'Pulmonary Disease, Chronic Obstructive-manage-Asthma', 'Lymphoma-transformed-Epstein-Barr Virus Infections', 'Death-observed-Angina Pectoris', 'Diabetes Mellitus-report-Memory Disorders', 'Delirium-name-Hereditary Breast and Ovarian Cancer Syndrome', 'Memory Disorders-associated-Ischemia', 'Ischemia-associated-Memory Disorders', 'Airway Obstruction-control-Asthma', 'Cerebral Infarction-differentiate-Stroke', 'Cerebral Small Vessel Diseases-associated-Death', 'Death-associated-Cerebral Small Vessel Diseases', 'Gastroesophageal Reflux-change-Dyspepsia', 'Gastroesophageal Reflux-change-Irritable Bowel Syndrome', 'Heart Failure-associated-Heart Failure, Systolic', 'Heart Failure, Systolic-associated-Heart Failure', 'Coronary Artery Disease-recorded-Cerebral Infarction', 'Heart Diseases-avert-Death', 'Hypertension-lead-Kidney Diseases', 'Alzheimer Disease-give-Dementia', 'Death-sustain-Myocardial Infarction', 'Coronary Artery Disease-occur-Myocardial Infarction', 'Pain-denote-Coronary Artery Disease', 'Coronary Artery Disease-denote-Dyspnea', 'Pain-appear-Coronary Artery Disease', 'Chest Pain-increase-Dyspnea', 'Heart Diseases-include-Colitis, Ischemic', 'Hypovolemia-include-Colitis, Ischemic', 'Memory Disorders-observed-Parkinson Disease', 'Memory Disorders-observed-Brain Diseases', 'Osteoporosis-lead-Osteomalacia', 'Immunologic Deficiency Syndromes-lead-Osteomalacia', 'Bone Neoplasms-reverse-Adrenal Insufficiency', 'Death-related-Dyspnea', 'Cross Infection-include-Pneumonia', 'Hypertension-increase-Hemorrhage', 'Hyperglycemia-include-Glucose Intolerance', 'Pericarditis, Constrictive-characterized-Calcinosis', 'Pericarditis, Constrictive-characterized-Fever', 'Pericarditis, Constrictive-characterized-Weight Loss', 'Pericarditis, Constrictive-characterized-Tuberculosis', 'Sleep Wake Disorders-include-Dementia', 'Osteoarthritis-study-Arthritis, Rheumatoid', 'Arthritis, Rheumatoid-study-Osteonecrosis', 'Neoplasms-reflect-Brain Neoplasms', 'Parkinson Disease, Secondary-observed-Alzheimer Disease', 'Malnutrition-prevent-Chronic Disease', 'Fibromyalgia-correlate-Pain', 'Pain-correlate-Fibromyalgia', 'Pain-include-Fibromyalgia', 'Fatigue-correlate-Fibromyalgia', 'Fatigue-include-Fibromyalgia', 'Stroke-modified-Infarction', 'Stroke-increase-Infarction', 'Atrial Fibrillation-associated-Infarction', 'Infarction-associated-Atrial Fibrillation', 'Stroke-reassessed-Dementia', 'Infections-include-Alcoholism', 'Infections-include-Neoplasms', 'Infections-include-Cerebrovascular Disorders', 'Infections-include-Liver Cirrhosis', 'Neuronal Ceroid-Lipofuscinoses-appreciated-Lysosomal Storage Diseases', 'Neuronal Ceroid-Lipofuscinoses-represent-Lysosomal Storage Diseases', 'Infections-control-Hemorrhage', 'Hemorrhage-err-Heart Failure', 'Peritoneal Neoplasms-missed-Fever', 'Hepatic Encephalopathy-confused-Alzheimer Disease', 'Cholera-indicated-Colitis', 'Osteoporotic Fractures-classified-Nervous System Diseases', 'Osteoporotic Fractures-individualized-Fractures, Bone', 'Pneumonia-predispose-Pulmonary Disease, Chronic Obstructive', 'Pneumonia-predispose-Heart Failure', 'Pneumonia-predispose-Diabetes Mellitus', 'Intracranial Hemorrhages-include-Thromboembolism', 'Brain Injuries, Traumatic-sustain-Venous Thromboembolism', 'Diabetes Mellitus-increased-Coronary Artery Disease', 'Dementia-characterized-Death', 'Brain Diseases-characterized-Nerve Degeneration', 'Brain Diseases-characterized-Death', 'Small Cell Lung Carcinoma-demonstrate-Neoplasms', 'Breast Neoplasms-represent-Neoplasms', 'Breast Neoplasms-control-Neoplasms', 'Inflammation-play-Glucose Metabolism Disorders', 'Dystonia-lead-Intellectual Disability', 'Ovarian Diseases-associated-Hypothalamic Diseases', 'Hypothalamic Diseases-associated-Ovarian Diseases', 'Intraoperative Complications-show-Heart Arrest', 'Infections-occur-Wounds and Injuries', 'Hematoma, Subdural-improve-Hematoma, Subdural, Chronic', 'Pain-associate-Neoplasm Metastasis', 'Neoplasm Metastasis-associate-Pain', 'Neoplasms-include-Chronic Pain', 'Diabetic Neuropathies-include-Chronic Pain', 'Neoplasms-related-Pain', 'Neuralgia-include-Pain', 'Diabetic Neuropathies-include-Pain', 'Osteoporosis-evidence-Hip Fractures', 'Heterotaxy Syndrome-reflect-Hypertension', 'Chronic Disease-suffer-Cystic Fibrosis', 'Pulmonary Disease, Chronic Obstructive-outweigh-Signs and Symptoms, Respiratory', 'Hematuria-caused-Neoplasms', 'Breast Neoplasms-recorded-Neoplasms', 'Hematuria-evaluated-Infections', 'Meningitis-remain-Death', 'Urinary Bladder Neoplasms-range-Neoplasm Metastasis', 'Carcinoma, Papillary-range-Neoplasm Metastasis', 'Hyperglycemia-identified-Diabetes Mellitus', 'Death-find-Respiratory Tract Diseases', 'Death-find-Coronary Artery Disease', 'Death-find-Heart Failure', 'Infections-characterized-Eosinophilia', 'Memory Disorders-reversed-Cerebral Hemorrhage', 'Memory Disorders-modulated-Neurodegenerative Diseases', 'Cerebral Hemorrhage-modulated-Neurodegenerative Diseases', 'Cerebral Hemorrhage-reversed-Alzheimer Disease', 'Neurodegenerative Diseases-reversed-Alzheimer Disease', 'Diabetes Mellitus-associated-Bacteremia', 'Bacteremia-associated-Diabetes Mellitus', 'Neoplasms-associated-Bacteremia', 'Bacteremia-associated-Neoplasms', 'Plaque, Amyloid-considered-Dementia', 'Death, Sudden-contribute-Hypertension', 'Spondylitis, Ankylosing-use-Hip Dislocation, Congenital', 'Tuberculosis-continue-Communicable Diseases', 'Hypotension-show-Inflammation', 'Infections-examine-Kidney Failure, Chronic', 'Infections-examine-Diabetes Mellitus', 'Infections-related-Kidney Diseases', 'Coronary Artery Disease-prevent-Stroke', 'Death-occur-Tetany', 'Tetany-mean-Death', 'Atrial Fibrillation-become-Stroke', 'Hemorrhage-prevented-Ischemia', 'Cardiac Output, Low-sustain-Craniocerebral Trauma', 'Craniocerebral Trauma-fall-Stroke', 'Cerebrovascular Disorders-constitute-Epilepsy', 'Liver Diseases-include-Epilepsy', 'Neoplasms-relieve-Fatigue', 'Neoplasms-relieve-Muscle Weakness', 'Atherosclerosis-share-Inflammation', 'Heart Diseases-regarded-Hemolytic-Uremic Syndrome', 'Arbovirus Infections-related-Pneumonia', 'Inflammation-seen-Atherosclerosis', 'Head and Neck Neoplasms-include-Neoplasms', 'Carcinogenesis-occur-Death', 'Cardiovascular Diseases-related-Thrombosis', 'Kidney Diseases-related-Thrombosis', 'Infarction-affected-Infarction, Middle Cerebral Artery', 'Delirium-treated-Infections', 'Nystagmus, Pathologic-sustain-Fractures, Bone', 'Mastocytosis-supposed-Skin Diseases', 'Nystagmus, Pathologic-coincide-Fractures, Bone', 'Mastocytosis-known-Urticaria Pigmentosa', 'Alzheimer Disease-differ-Acquired Immunodeficiency Syndrome', 'Alzheimer Disease-differ-Neoplasms', 'Coronary Artery Disease-confirm-Epilepsy, Absence', 'Diabetic Neuropathies-use-Nervous System Diseases', 'Drug-Related Side Effects and Adverse Reactions-performed-Leukemia, Myeloid, Acute', 'Drug-Related Side Effects and Adverse Reactions-performed-Myelodysplastic Syndromes', 'Drug-Related Side Effects and Adverse Reactions-performed-Hodgkin Disease', 'Drug-Related Side Effects and Adverse Reactions-performed-Multiple Myeloma', 'Asthma-present-Glaucoma', 'Asthma-associated-Glaucoma', 'Glaucoma-associated-Asthma', 'Stroke-associated-Hallucinations', 'Hallucinations-associated-Stroke', 'Bacteremia-complicated-Bacteriuria', 'Memory Disorders-correlated-Alzheimer Disease', 'Diabetes Mellitus-occur-Thyroid Diseases', 'Chronic Disease-added-Death', 'Colorectal Neoplasms-account-Neoplasms', 'Adenoma-followed-Neoplasms', 'Adenoma, Oxyphilic-followed-Neoplasms', 'Nerve Degeneration-protect-Brain Injuries, Traumatic', 'Ischemia-reduce-Death', 'Gastrointestinal Hemorrhage-caused-Ulcer', 'Hearing Loss-involve-Wounds and Injuries', 'Hearing Loss-involve-Hearing Disorders', 'Wounds and Injuries-involve-Hearing Disorders', 'Dementia, Vascular-follow-Alzheimer Disease', 'Dementia, Vascular-benefit-Alzheimer Disease', 'Death-treated-Arthritis, Rheumatoid', 'Nocturia-correlate-Urinary Incontinence', 'Fever-sold-Death', 'Drug-Related Side Effects and Adverse Reactions-measured-Pheochromocytoma', 'Drug-Related Side Effects and Adverse Reactions-measured-Neuroblastoma', 'Nerve Degeneration-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-Nerve Degeneration', 'Seizures-underlie-Brain Diseases', 'Candidiasis, Oral-explored-Adrenal Insufficiency', 'Chronic Pain-experienced-Joint Diseases', 'Joint Diseases-experienced-Visceral Pain', 'Temporomandibular Joint Disorders-defined-Pain', 'Hyponatremia-classified-Inappropriate ADH Syndrome', 'Ocular Hypertension-involved-Glaucoma', 'Glaucoma-show-Ischemia', 'Atherosclerosis-link-Ischemia', 'Intestinal Polyposis-attributed-Olfaction Disorders', 'Parkinson Disease, Secondary-affect-Hearing Loss, Unilateral', 'Infections-implicated-Hemolytic-Uremic Syndrome', 'Escherichia coli Infections-implicated-Hemolytic-Uremic Syndrome', 'Anemia, Hemolytic-characterized-Thrombocytopenia', 'Anemia, Hemolytic-characterized-Renal Insufficiency', 'Hemolytic-Uremic Syndrome-characterized-Anemia, Hemolytic', 'Hemolytic-Uremic Syndrome-characterized-Thrombocytopenia', 'Hemolytic-Uremic Syndrome-characterized-Renal Insufficiency', 'Bradycardia-establish-Heart Arrest', 'Bradycardia-suffer-Syncope', 'Anemia-correlate-Inflammation', 'Hypotension-cause-Death, Sudden', 'Vipoma-cause-Diarrhea', 'Sepsis-define-Infections', 'Sepsis-define-Multiple Organ Failure', 'Vision Disorders-caused-Anophthalmos', 'Adrenal Insufficiency-characterized-Hyperparathyroidism, Secondary', 'Adrenal Insufficiency-characterized-Osteoporotic Fractures', 'Leukemia-use-Neoplasms', 'Spinal Cord Injuries-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-Spinal Cord Injuries', 'Spinal Cord Injuries-associated-Cerebrovascular Disorders', 'Cerebrovascular Disorders-associated-Spinal Cord Injuries', 'Spinal Cord Injuries-associated-Arrhythmias, Cardiac', 'Arrhythmias, Cardiac-associated-Spinal Cord Injuries', 'Spinal Cord Injuries-associated-Heart Valve Diseases', 'Heart Valve Diseases-associated-Spinal Cord Injuries', 'Stroke-admitted-Brain Infarction', 'Xeroderma Pigmentosum-develop-Neoplasms', 'Arbovirus Infections-remain-Death', 'Diabetes Mellitus-identify-Hypertension', 'Otitis-lead-Hearing Loss', 'Myelodysplastic Syndromes-compared-Leukemia, Myeloid, Acute', 'Death-occur-Death, Sudden', 'Atrial Fibrillation-investigate-Death', 'Atrial Fibrillation-investigate-Cardiomyopathy, Hypertrophic', 'Infarction-categorized-Thrombosis', 'Infarction-categorized-Embolism', 'Heart Diseases-characterized-Ventricular Septal Rupture', 'Heart Diseases-characterized-Hypertrophy, Right Ventricular', 'Heart Diseases-characterized-Heart Septal Defects, Atrial', 'Stroke-result-Deglutition Disorders', 'Stroke-result-Constipation', 'Stroke-result-Fecal Incontinence', 'Paralysis, Obstetric-result-Deglutition Disorders', 'Paralysis, Obstetric-result-Constipation', 'Paralysis, Obstetric-result-Fecal Incontinence', 'Pancreatic Neoplasms-reduce-Drug-Related Side Effects and Adverse Reactions', 'Infections-excluded-Diarrhea', 'Gastrointestinal Diseases-excluded-Diarrhea', 'Osteoporosis-managed-Inflammatory Bowel Diseases', 'Ischemia-see-Atherosclerosis', 'Malabsorption Syndromes-thrive-Weight Loss', 'Exocrine Pancreatic Insufficiency-thrive-Weight Loss', 'Blind Loop Syndrome-considered-Weight Loss', 'Aortic Valve Insufficiency-cause-Ventricular Fibrillation', 'Aortic Valve Insufficiency-result-Death', 'Ventricular Fibrillation-result-Death', 'Hearing Loss-hear-Hearing Disorders', 'Cardiac Output, High-maintain-Stroke', 'Heart Arrest-associated-Myocardial Infarction', 'Myocardial Infarction-associated-Heart Arrest', 'Hypotension-associated-Heart Arrest', 'Heart Arrest-associated-Hypotension', 'Heart Failure-associated-Heart Arrest', 'Heart Arrest-associated-Heart Failure', 'Bradycardia-associated-Heart Arrest', 'Heart Arrest-associated-Bradycardia', 'Tachycardia-associated-Heart Arrest', 'Heart Arrest-associated-Tachycardia', 'Mitochondrial Diseases-identified-Deafness', 'Leukocytosis-observed-Thrombocytosis', 'Diabetic Nephropathies-fulfilled-Albuminuria', 'Diabetic Nephropathies-fulfilled-Diabetes Mellitus', 'Diabetic Nephropathies-fulfilled-Kidney Diseases', 'Musculoskeletal Diseases-related-Communicable Diseases', 'Poisoning-comprise-Death', 'Aortic Aneurysm-contain-Hemorrhage', 'Rupture-associated-Inflammation', 'Inflammation-associated-Rupture', 'Retroperitoneal Neoplasms-given-Hypotension', 'Heart Failure, Diastolic-occur-Heart Failure', 'Hypertension-related-Aneurysm', 'Heart Failure-result-Hypertension', 'Hypotension-occur-Hypertension', 'Hypotension-occur-Coronary Artery Disease', 'Fibrosis-occur-Hypertension', 'Appendicitis-present-Abdominal Pain', 'Sleep Initiation and Maintenance Disorders-identified-Intellectual Disability', 'Sleep Initiation and Maintenance Disorders-defined-Intellectual Disability', 'Dementia-result-Ischemia', 'Dementia-result-Hypoxia, Brain', 'Diverticular Diseases-caused-Hemorrhage', 'Diverticular Diseases-caused-Rupture', 'Dementia-result-Brain Damage, Chronic', 'Hemorrhage-caused-Rupture', 'Dementia-result-Cerebrovascular Disorders', 'Gastrointestinal Hemorrhage-followed-Angiodysplasia', 'Death-result-Neurodegenerative Diseases', 'Death-result-Diabetes Mellitus', 'Sleep Initiation and Maintenance Disorders-related-Low Back Pain', 'Low Back Pain-report-Sleep Initiation and Maintenance Disorders', 'Nervous System Diseases-observed-Mitochondrial Diseases', 'Death-used-Heart Diseases', 'Death-used-Breast Neoplasms', 'Death-used-Osteoporosis', 'Aneurysm-associated-Hypertrophy, Left Ventricular', 'Hypertrophy, Left Ventricular-associated-Aneurysm', 'Fractures, Bone-account-Bronchopneumonia', 'Death-account-Bronchopneumonia', 'Pain-relieve-Arthralgia', 'Brain Neoplasms-seen-Cockayne Syndrome', 'Hip Fractures-reduce-Bone Neoplasms', 'Goiter-considered-Congenital Hypothyroidism', 'Infections-include-Tinea', 'Olfaction Disorders-identify-Dementia', 'Cardiomyopathy, Dilated-experience-Death', 'Tachycardia, Ventricular-experience-Death', 'Cardiac Output, Low-occur-Myocardial Infarction', 'Cardiac Output, Low-occur-Renal Insufficiency', 'Cardiac Output, Low-occur-Stroke', 'Venous Thromboembolism-needed-Drug Hypersensitivity', 'Venous Thrombosis-confined-Pulmonary Embolism', 'Eye Diseases-center-Coma', 'Vision, Low-decrease-Inert Gas Narcosis', 'Leukemia, Myeloid, Acute-follow-Myelodysplastic Syndromes', 'Drug-Related Side Effects and Adverse Reactions-document-Infections', 'Leukopenia-document-Infections', 'Wounds and Injuries-display-Death', 'Neoplasms-regarded-Neurodegenerative Diseases', 'Osteoporosis-characterised-Fractures, Bone', 'Osteoporosis-promote-Fractures, Bone', 'Osteoporosis-restore-Bone Neoplasms', 'Osteoporosis-treat-Psoriasis', 'Fractures, Bone-restore-Bone Neoplasms', 'Fractures, Bone-treat-Psoriasis', 'Bone Neoplasms-treat-Psoriasis', 'Inflammation-identified-Infertility, Male', 'Aortic Aneurysm, Abdominal-derived-Death', 'Nervous System Diseases-preserve-Neoplasms', 'Nervous System Diseases-correlate-Neoplasms', 'Nephrotic Syndrome-follow-Glomerulosclerosis, Focal Segmental', 'Neoplasms-exploit-Brain Neoplasms', 'Crystal Arthropathies-foster-Genetic Diseases, Inborn', 'Infections-receive-Pneumonia, Pneumocystis', 'HIV Infections-carry-Death', 'Drug-Related Side Effects and Adverse Reactions-treat-Rheumatic Diseases', 'Stiff-Person Syndrome-impaired-Nervous System Diseases', 'Erectile Dysfunction-develop-Myocardial Infarction', 'Coronary Artery Disease-present-Erectile Dysfunction', 'Death-include-Liver Diseases, Alcoholic', 'Werner Syndrome-manifested-Atherosclerosis', 'Werner Syndrome-manifested-Neoplasms', 'Genetic Diseases, Inborn-manifested-Atherosclerosis', 'Genetic Diseases, Inborn-manifested-Neoplasms', 'Mastocytosis, Systemic-relapse-Polychondritis, Relapsing', 'Wounds and Injuries-result-Dry Eye Syndromes', 'Wounds and Injuries-result-Vision Disorders', 'Obesity-confer-Death', 'Low Back Pain-derived-Spinal Stenosis', 'Hearing Disorders-report-Tinnitus', 'Hearing Loss-report-Tinnitus', 'Mastocytosis, Systemic-present-Cataract', 'Mastocytosis, Systemic-affect-Death', 'Cataract-affect-Death', 'Heart Arrest-delay-Renal Insufficiency', 'Heart Arrest-delay-Kidney Failure, Chronic', 'Psychoses, Substance-Induced-ameliorate-Genetic Diseases, Inborn', 'Atrial Fibrillation-manifest-Hypertension', 'Atrial Fibrillation-manifest-Diabetes Mellitus', 'Inflammation-viewed-Colitis, Ulcerative', 'Atherosclerosis-hypothesize-Cataract', 'Cataract-associated-Coronary Artery Disease', 'Coronary Artery Disease-associated-Cataract', 'Cataract-associated-Myocardial Infarction', 'Myocardial Infarction-associated-Cataract', 'Cataract-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-Cataract', 'Atherosclerosis-identified-Calcinosis', 'Drug Overdose-complicated-Chemical and Drug Induced Liver Injury', 'Hypothyroidism-contribute-Dementia', 'Dementia-formulated-Alzheimer Disease', 'Parkinson Disease-contribute-Dementia', 'Cardiovascular Diseases-known-Dementia', 'Meningitis-result-Cerebral Ventriculitis', 'Meningitis-result-Brain Abscess', 'Meningitis-result-Hydrocephalus', 'Hypertension-paralleled-Heart Failure, Diastolic', 'Diabetes Mellitus-paralleled-Heart Failure, Diastolic', 'Death-recover-Central Nervous System Infections', 'Meningitis-recover-Central Nervous System Infections', 'Genetic Diseases, Inborn-characterized-Coronary Artery Disease', 'Abnormalities, Drug-Induced-associated-Respiratory Insufficiency', 'Respiratory Insufficiency-associated-Abnormalities, Drug-Induced', 'Respiratory Insufficiency-associated-Brain Diseases', 'Brain Diseases-associated-Respiratory Insufficiency', 'Inflammation-related-Alzheimer Disease', 'Inflammation-promote-Alzheimer Disease', 'Inflammation-promote-Diabetes Mellitus', 'Osteoporosis-account-Osteoporotic Fractures', 'Osteoporosis-account-Death', 'Osteoporotic Fractures-account-Death', 'Parasitic Diseases-produce-Mastocytosis, Systemic', 'Parasitic Diseases-produce-Skin Diseases', 'Leishmaniasis, Cutaneous-include-Parasitic Diseases', 'Ventricular Dysfunction, Left-reduce-Myocardial Infarction', 'Pyelitis-associated-Infections', 'Infections-associated-Pyelitis', 'Pyelitis-associated-Hematuria', 'Hematuria-associated-Pyelitis', 'Obesity, Abdominal-recognized-Cardiovascular Diseases', 'Hyponatremia-derived-Hypopituitarism', 'Hereditary Angioedema Type III-increase-Alzheimer Disease', 'Aneurysm-demonstrate-Thrombosis', 'Obesity-related-Carcinogenesis', 'Magnesium Deficiency-decrease-Cardiovascular Diseases', 'Xeroderma Pigmentosum-characterized-Melanoma', 'Acquired Immunodeficiency Syndrome-impacted-Infections', 'Diabetes Mellitus-resolve-Hypertension', 'Diabetes Mellitus-resolve-Sleep Apnea Syndromes', 'Tuberculosis-lead-Death', 'Memory Disorders-convert-Alzheimer Disease', 'Lung Neoplasms-achieved-Drug-Related Side Effects and Adverse Reactions', 'Alzheimer Disease-meet-Dementia', 'Psychomotor Disorders-assessed-Intellectual Disability', 'Neoplasms-defined-Adenocarcinoma', 'Hepatitis, Viral, Human-directed-Hepatitis C, Chronic', 'Hepatitis B-directed-Hepatitis C, Chronic', 'Hepatitis C, Chronic-tested-Hepatitis, Viral, Human', 'Hepatitis B-associated-Hepatitis, Viral, Human', 'Hepatitis, Viral, Human-associated-Hepatitis B', 'Hepatitis C, Chronic-tested-Hepatitis B', 'Hepatitis B-increased-Hepatitis C, Chronic', 'Hepatitis B-undertaken-Hepatitis C, Chronic', 'Dementia, Vascular-respond-Alzheimer Disease', 'Brain Ischemia-result-Cerebral Infarction', 'Brain Ischemia-appear-Dementia', 'Neoplasms-become-Heart Arrest', 'Hypertension-engender-Headache', 'Hypertension-engender-Death', 'Prostatitis-referred-Prostatic Hyperplasia', 'Death-compared-Seizures', 'Pulmonary Embolism-underlie-Heart Arrest', 'Atherosclerosis-lead-Coronary Thrombosis', 'Plaque, Atherosclerotic-compared-Calcinosis', 'Autoimmune Diseases-constitute-Drug Hypersensitivity Syndrome', 'Constipation-urge-Nausea', 'Pneumococcal Infections-increase-Neoplasm Invasiveness', 'Immunologic Deficiency Syndromes-found-Genetic Diseases, Inborn', 'Fractures, Bone-account-Osteoporotic Fractures', 'Hip Fractures-predict-Femoral Neck Fractures', 'Malnutrition-associated-Osteoporosis', 'Osteoporosis-associated-Malnutrition', 'Malnutrition-occur-Protein S Deficiency', 'Osteoporosis-involved-Protein S Deficiency', 'Osteoporosis-occur-Protein S Deficiency', 'Deglutition Disorders-detect-Pneumonia', 'Plasmacytoma-resemble-Bone Diseases', 'Sinusitis-compare-Atrioventricular Block', 'Sinusitis-compare-Sick Sinus Syndrome', 'Sinusitis-compare-Atrial Fibrillation', 'Bone Diseases-applied-Multiple Myeloma', 'Arrhythmias, Cardiac-document-Syncope', 'Peripheral Vascular Diseases-used-Neuralgia', 'Coronary Artery Disease-used-Neuralgia', 'Hearing Disorders-administered-Hearing Loss', 'Hemostatic Disorders-experience-Hemorrhage', 'Hemostatic Disorders-suffer-Hemorrhage', 'Arrhythmias, Cardiac-culminate-Death, Sudden', 'Torsades de Pointes-culminate-Death, Sudden', 'Anorexia-characterized-Weight Loss', 'Myocardial Infarction-worsen-Death', 'Lysosomal Storage Diseases-reduced-Neoplasms', 'Neoplasms-reduced-Carcinoma', 'Hyperparathyroidism-increase-Cardiovascular Diseases', 'Coronary Aneurysm-reported-Dementia, Vascular', 'Coronary Stenosis-reported-Dementia, Vascular', 'Heart Diseases-underlie-Ventricular Dysfunction', 'Coronary Aneurysm-considered-Metabolic Diseases', 'Coronary Stenosis-considered-Metabolic Diseases', 'Drug-Related Side Effects and Adverse Reactions-short-Neutropenia', 'Arrhythmias, Cardiac-individualized-Heart Diseases', 'Musculoskeletal Diseases-associated-Limb Deformities, Congenital', 'Limb Deformities, Congenital-associated-Musculoskeletal Diseases', 'Nervous System Diseases-exhibit-Neurodegenerative Diseases', 'Sensation Disorders-depend-Diabetes Mellitus', 'Death-result-Hypertension', 'Hypertension-appear-Diabetes Mellitus, Type 2', 'Sleep Wake Disorders-index-Respiratory Insufficiency', 'Hypertension-offer-Stroke', 'Hypertension-offer-Myocardial Infarction', 'Calcinosis-find-Carotid Stenosis', 'Calcinosis-find-Coronary Stenosis', 'Calcinosis-find-Peripheral Arterial Disease', 'Hemangioma-considered-Vitreous Detachment', 'Diabetes Mellitus-become-Dyslipidemias', 'Dementia-occur-Alzheimer Disease', 'Death-diagnosed-Asphyxia', 'Glucose Intolerance-learne-Edema', 'Hypothermia-suffer-Coma', 'Epilepsy-exhibit-Death', 'Hypothermia-present-Hypotension', 'Hypothermia-present-Shock', 'Hypotension-present-Shock', 'Death-intersect-Atrial Fibrillation', 'Heart Failure-facilitate-Bradycardia', 'Bradycardia-play-Heart Failure', 'Dementia-indicate-Alzheimer Disease', 'Adrenal Insufficiency-cause-Hypothalamic Neoplasms', 'Delirium-considered-Psychomotor Agitation', 'Delirium-considered-Psychoses, Substance-Induced', 'Prostatic Neoplasms-secreted-Neoplasms', 'Prostatic Neoplasms-secreted-Neoplasm Metastasis', 'Apnea-occur-Nervous System Diseases', 'Apnea-occur-Infarction', 'Apnea-occur-Neoplasms', 'Apnea-occur-Infections', 'Apnea-occur-Brain Diseases', 'Apnea-occur-Heart Failure', 'Sleep Wake Disorders-appear-Dementia', 'Alzheimer Disease-occur-Sleep Wake Disorders', 'Neoplasms-contribute-Neoplasm Metastasis', 'Thrombosis-protect-Acute Disease', 'Stroke-cause-Atherosclerosis', 'Death-possess-Atherosclerosis', 'Cardiovascular Diseases-possess-Atherosclerosis', 'Pneumonia-become-Infections', 'Pneumonia-increase-Cough', 'Aneurysm-result-Stroke', 'Pneumonia-lessen-Infections', 'Pneumonia-review-Cerebrovascular Disorders', 'Heart Failure-caused-Heart Failure, Diastolic', 'Communicable Diseases-account-Death', 'Death-result-Pneumonia', 'Thyroid Diseases-imply-Thyroiditis, Autoimmune', 'Thyroid Diseases-reflect-Inflammation', 'Exostoses-followed-Neoplasms', 'Neoplasms-followed-Exostoses', 'Delirium-related-Brain Diseases', 'Delirium-known-Brain Diseases', 'Diabetes Mellitus-examined-Peripheral Nervous System Diseases', 'Peripheral Nervous System Diseases-adjusted-Diabetes Mellitus', 'Peripheral Nervous System Diseases-remain-Diabetes Mellitus', 'Pelvic Floor Disorders-defined-Urinary Incontinence', 'Rhinitis-include-Drug Hypersensitivity', 'Polyps-include-Drug Hypersensitivity', 'Hypothyroidism-include-Drug Hypersensitivity', 'Rhinitis, Vasomotor-include-Drug Hypersensitivity', 'Neoplasms-include-Drug Hypersensitivity', 'Bronchitis-include-Cough', 'Dyskinesia, Drug-Induced-seem-Akathisia, Drug-Induced', 'Heart Failure-include-Cough', 'Lung Neoplasms-include-Cough', 'Vocal Cord Dysfunction-include-Cough', 'Dyspnea-include-Bronchitis', 'Akathisia, Drug-Induced-seem-Dystonia', 'Dyspnea-include-Heart Failure', 'Dyspnea-include-Lung Neoplasms', 'Vocal Cord Dysfunction-include-Dyspnea', 'Werner Syndrome-develop-Arteriosclerosis', 'Werner Syndrome-develop-Atherosclerosis', 'Werner Syndrome-develop-Calcinosis', 'Sleep Wake Disorders-manifested-Respiratory Insufficiency', 'Sleep Wake Disorders-investigate-Respiratory Insufficiency', 'Sleep Wake Disorders-manifested-Sleepiness', 'Respiratory Insufficiency-manifested-Sleepiness', 'Hypertrophy, Left Ventricular-recognized-Death, Sudden', 'Hypertrophy, Left Ventricular-recognized-Voice Disorders', 'Heart Failure-enrol-Hypertension', 'Arrhythmias, Cardiac-compare-Hypertension', 'Arrhythmias, Cardiac-related-Hypertension', 'Fibrosis-accompany-Hypertension', 'Hypertension-accompany-Arrhythmias, Cardiac', 'Acquired Immunodeficiency Syndrome-considered-Cardiomyopathies', 'Xeroderma Pigmentosum-present-Carcinoma, Squamous Cell', 'Xeroderma Pigmentosum-present-Melanoma', 'Xeroderma Pigmentosum-present-Nervous System Neoplasms', 'Hypotension-mount-Tachycardia', 'Atrophy-detect-Alzheimer Disease', 'Parkinson Disease-caused-Death', 'Hypertension-ensue-Dementia', 'Skin Diseases-prove-Scabies', 'Scabies-misdiagnosed-Eczema', 'Death-present-Status Asthmaticus', 'Hemangioma-range-Neoplasms', 'Aneurysm-observed-Stroke', 'Granuloma, Pyogenic-range-Neoplasms', 'Neoplasms-range-Hemangiosarcoma', 'Bone Neoplasms-develop-Hereditary Angioedema Type III', 'Death-present-Prostatic Diseases', 'Heart Failure-follow-Heart Diseases', 'Myocardial Infarction-hospitalized-Diabetes Mellitus', 'Myocardial Infarction-hospitalized-Death', 'Diabetes Mellitus-evaluate-Death', 'Death-contribute-Infections', 'Basal Ganglia Diseases-enhance-Nervous System Diseases', 'Coronary Artery Disease-ascertained-Death', 'Coronary Artery Disease-incur-Obesity', 'Coronary Artery Disease-incur-Diabetes Mellitus', 'Coronary Artery Disease-incur-Hypertension', 'Tooth Loss-reduce-Periodontal Diseases', 'Alzheimer Disease-characterised-Atrophy', 'Neurodegenerative Diseases-characterised-Atrophy', 'Foramen Ovale, Patent-fail-Fractures, Bone', 'Foramen Ovale, Patent-happen-Fractures, Bone', 'Cardiovascular Diseases-indicate-Coronary Artery Disease', 'Cranial Nerve Diseases-detected-Glioblastoma', 'Neoplasms, Neuroepithelial-detected-Glioblastoma', 'Multiple Sclerosis-alleviate-Tremor', 'Spasm-alleviate-Tremor', 'Pain-alleviate-Tremor', 'Tachycardia, Supraventricular-occur-Heart Diseases', 'Dementia-attributed-Brain Diseases', 'Diabetes Mellitus-associated-Cholelithiasis', 'Cholelithiasis-associated-Diabetes Mellitus', 'Carotid Artery Diseases-correlate-Atherosclerosis', 'Glaucoma-undergo-Glaucoma, Open-Angle', 'Glaucoma-collected-Cataract', 'Glaucoma, Open-Angle-undergo-Cataract', 'Pain-reduce-Inflammation', 'Pain-reduce-Polyradiculoneuropathy, Chronic Inflammatory Demyelinating', 'Hypotension-include-Ulcer', 'Ulcer-include-Alcoholism', 'Osteoporosis-include-Ulcer', 'Alcoholism-include-Ulcer', 'Osteoporosis-underestimate-Bone Neoplasms', 'Ulcer-include-Osteoporosis', 'Werner Syndrome-show-Muscular Atrophy', 'Werner Syndrome-show-Osteoporosis', 'Werner Syndrome-show-Cataract', 'Werner Syndrome-show-Hypogonadism', 'Werner Syndrome-show-Diabetes Mellitus', 'Werner Syndrome-show-Hyperlipidemias', 'Werner Syndrome-show-Atherosclerosis', 'Werner Syndrome-show-Alzheimer Disease', 'Polymyalgia Rheumatica-involve-Hip Dislocation, Congenital', 'Heart Block-increase-Death', 'Heart Block-remain-Death', 'Heart Block-associated-Death', 'Death-associated-Heart Block', 'Nystagmus, Pathologic-analyzed-Vestibular Neuronitis', 'Neurologic Manifestations-reverse-Stroke', 'Dementia-worsen-Inflammation', 'Tuberculosis-defined-Infections', 'Tuberculosis-recognized-Infections', 'Tuberculosis-control-Infections', 'Infections-control-Acquired Immunodeficiency Syndrome', 'Infections-contribute-Chronic Disease', 'Atrial Flutter-increase-Heart Failure', 'Atrial Flutter-increase-Pulmonary Disease, Chronic Obstructive', 'Pelvic Neoplasms-required-Fractures, Bone', 'Wounds and Injuries-required-Fractures, Bone', 'Hypotension-treated-Sciatic Neuropathy', 'Hip Fractures-guid-Sciatic Neuropathy', 'Osteoporosis-link-Breast Neoplasms', 'Osteoporosis-link-Osteoarthritis', 'Osteoporosis-link-Stroke', 'Diabetes Insipidus-linked-Alzheimer Disease', 'Osteoporotic Fractures-remain-Hypogonadism', 'Glucose Intolerance-precede-Diabetes Mellitus, Type 2', 'Diabetes Mellitus, Type 2-precede-Glucose Intolerance', 'Alzheimer Disease-sundown-Sleep Wake Disorders', 'Dementia-sundown-Sleep Wake Disorders', 'Hypertension-known-Heart Failure', 'Arrhythmias, Cardiac-found-Edema', 'Arrhythmias, Cardiac-recorded-Heart Failure', 'Arrhythmias, Cardiac-recorded-Atrial Fibrillation', 'Hypertrophy, Left Ventricular-noted-Myocardial Infarction', 'Hypertrophy, Left Ventricular-noted-Heart Diseases', 'Dementia-exhibit-Alzheimer Disease', 'Kidney Diseases-composed-Neoplasms', 'Syncope-associated-Bradycardia', 'Bradycardia-associated-Syncope', 'Arteritis-associated-Fever', 'Fever-associated-Arteritis', 'Ulcer-contribute-Ischemia', 'Kidney Diseases-develop-Proteinuria', 'Kidney Diseases-develop-Renal Insufficiency', 'Airway Obstruction-measured-Infarction, Middle Cerebral Artery', 'Thrombosis-stimulate-Inflammation', 'Stroke-offer-Coronary Occlusion', 'Stroke-prevent-Myocardial Infarction', 'Stroke-prevent-Angina, Unstable', 'Bone Neoplasms-include-Osteoporosis', 'Bone Neoplasms-include-Osteomalacia', 'Hypertension-shown-Death', 'Hypertension-carry-Death', 'Myocardial Infarction-recommend-Hypertension', 'Heart Failure-recommend-Hypertension', 'Brain Neoplasms-benefit-Neoplasms', 'Alzheimer Disease-stratified-Death', 'Muscular Atrophy-protect-Neurodegenerative Diseases', 'Adrenal Insufficiency-indicate-Arthritis, Rheumatoid', 'Osteoporosis-lead-Drug-Related Side Effects and Adverse Reactions', 'Hypertension-place-Hypotension, Orthostatic', 'Hypertension-place-Syncope, Vasovagal', 'Hypertension-place-Death, Sudden, Cardiac', 'Osteoporosis-assess-Bone Neoplasms', 'Epilepsy-increase-Death', 'Hearing Loss-increase-Death', 'Neoplasms-obtain-Microsatellite Instability', 'Colorectal Neoplasms-contribute-Microsatellite Instability', 'Neoplasms-observed-Microsatellite Instability', 'Neoplasms-observed-Colorectal Neoplasms', 'Microsatellite Instability-observed-Colorectal Neoplasms', 'Hypertension-obviate-Aneurysm', 'Gallbladder Neoplasms-compare-Gallstones', 'Prostatic Hyperplasia-coexist-Erectile Dysfunction', 'Plaque, Amyloid-occur-Alzheimer Disease', 'Aortic Diseases-occur-Alzheimer Disease', 'Alzheimer Disease-recognise-Death', 'Nerve Degeneration-caused-Seizures', 'Atrophy-accompany-Neurologic Manifestations', 'Infections-threatened-Death', 'Fractures, Bone-known-Osteoporosis', 'Cardiovascular Diseases-treat-Hypertension', 'Brain Diseases-cause-Epilepsies, Myoclonic', 'Acidosis, Lactic-cause-Epilepsies, Myoclonic', 'Osteomyelitis-develop-Infections', 'Motor Neuron Disease-develop-Nerve Degeneration', 'Death-preceded-Neurodegenerative Diseases', 'Sarcopenia-reduce-Pain', 'Sarcopenia-normalise-Osteoarthritis', 'Pneumonia-occur-Delirium', 'Pneumonia-issued-Communicable Diseases', 'Pneumonia-considered-Tuberculosis', 'Heart Failure-rated-Alzheimer Disease', 'Tetany-occur-Whooping Cough', 'Heart Failure-reported-Alzheimer Disease', 'Neurotoxicity Syndromes-involved-Alzheimer Disease', 'Neurotoxicity Syndromes-involved-Dementia', 'Nerve Degeneration-evaluated-Alzheimer Disease', 'Leukemia-associated-Chromosome Aberrations', 'Chromosome Aberrations-associated-Leukemia', 'Drug-Related Side Effects and Adverse Reactions-supported-Hodgkin Disease', 'Leukemia, Myeloid, Acute-arise-Myelodysplastic Syndromes', 'Leukemia, Promyelocytic, Acute-associated-Leukemia, Myeloid, Acute', 'Leukemia, Myeloid, Acute-associated-Leukemia, Promyelocytic, Acute', 'Hypertension-arise-Stroke', 'Hypertension-arise-Dementia', 'Parkinsonian Disorders-consist-Neurogenic Inflammation', 'Sarcopenia-contribute-Death', 'Hypertension-found-Joint Diseases', 'Ischemia-constitute-Vasculitis', 'Vision Disorders-constitute-Vasculitis', 'Ischemia-develop-Blindness', 'Ischemia-observed-Blindness', 'Ischemia-precede-Blindness', 'Blindness-observed-Optic Neuropathy, Ischemic', 'Optic Neuropathy, Ischemic-precede-Blindness', 'Erythema Infectiosum-rank-Neoplasms', 'Erythema Infectiosum-rank-Death', 'Carcinoma, Non-Small-Cell Lung-produce-Drug-Related Side Effects and Adverse Reactions', 'Drug-Related Side Effects and Adverse Reactions-reported-Death', 'HIV Infections-avoided-Acquired Immunodeficiency Syndrome', 'Death-increased-Dementia', 'Death-increased-Delirium', 'Polyuria-result-Nocturia', 'Polyuria-result-Urinary Incontinence', 'Cardiac Output, Low-fall-Hypertension', 'Cardiac Output, Low-fall-Sensation Disorders', 'Osteoporotic Fractures-identified-Hypogonadism', 'Osteoporotic Fractures-identified-Alcoholism', 'Fractures, Bone-decrease-Spasm', 'Fractures, Bone-decrease-Pain', 'Fractures, Bone-cover-Pain', 'Kyphosis-decrease-Pain', 'Fractures, Bone-go-Osteoporosis', 'Spinal Fractures-reduce-Hip Fractures', 'Neoplasms-prevent-Prostatic Neoplasms', 'Hypophosphatemia-develop-Prostatic Hyperplasia', 'Hypophosphatemia-develop-Prostatic Neoplasms', 'Hypogonadism-related-Bone Neoplasms', 'Cachexia-associated-Infections', 'Infections-associated-Cachexia', 'Parkinsonian Disorders-use-Movement Disorders', 'Cardiovascular Diseases-extended-Dementia', 'Aneurysm-show-Rupture', 'Atherosclerosis-occur-Aneurysm, Ruptured', 'Hypertension-occur-Aneurysm, Ruptured', 'Aneurysm-related-Fragile X Syndrome', 'Diabetes Mellitus-screen-Obesity', 'Pneumococcal Infections-reduce-Neoplasm Invasiveness', 'Tetany-remain-Infections', 'Dyslipidemias-verify-Cardiovascular Diseases', 'Thyroid Diseases-evaluate-Genetic Diseases, Inborn', 'Cerebral Amyloid Angiopathy-occur-Genetic Diseases, Inborn', 'Alzheimer Disease-occur-Genetic Diseases, Inborn', 'Hemolytic-Uremic Syndrome-cause-Kidney Failure, Chronic', 'Diabetes Mellitus-include-Heart Arrest', 'Sleep Wake Disorders-result-Death', 'Adenocarcinoma-include-Stomach Neoplasms', 'Adenocarcinoma, Mucinous-include-Stomach Neoplasms', 'Adenocarcinoma, Scirrhous-include-Stomach Neoplasms', 'Carcinoma, Signet Ring Cell-include-Stomach Neoplasms', 'Adenocarcinoma, Mucinous-include-Neoplasms', 'Adenocarcinoma, Scirrhous-include-Neoplasms', 'Respiratory Tract Infections-include-Gonorrhea', 'Carcinoma, Signet Ring Cell-include-Neoplasms', 'Respiratory Tract Infections-include-Cat-Scratch Disease', 'Aneurysm-highlight-Hemorrhage', 'Streptococcal Infections-include-Gonorrhea', 'Streptococcal Infections-include-Cat-Scratch Disease', 'Tuberculosis-include-Gonorrhea', 'Tuberculosis-include-Cat-Scratch Disease', 'Gonorrhea-include-Cat-Scratch Disease', 'Atrial Fibrillation-include-Tachycardia, Supraventricular', 'Sepsis-caused-Kidney Failure, Chronic', 'Sepsis-caused-Diabetes Mellitus', 'Death-account-Diabetes Mellitus', 'Sepsis-remain-Diabetes Mellitus', 'Sepsis-remain-Kidney Failure, Chronic', 'Sepsis-account-Diabetes Mellitus', 'Kidney Failure, Chronic-account-Diabetes Mellitus', 'Paraplegia-result-Atherosclerosis', 'Fatigue-followed-Pain', 'Fatigue-followed-Muscle Weakness', 'Parkinson Disease-separate-Parkinson Disease, Secondary', 'Parkinson Disease-separated-Parkinson Disease, Secondary', 'Dementia-considered-Hip Fractures', 'Kidney Diseases-examine-Kidney Failure, Chronic', 'Ulcer-account-Diabetic Neuropathies', 'Brain Injuries-compare-Spinal Cord Injuries', 'Osteoporotic Fractures-appear-Death', 'Cerebral Amyloid Angiopathy-investigate-Infarction', 'Cerebral Amyloid Angiopathy-found-Cerebral Infarction', 'Memory Disorders-observe-Heart Arrest', 'Alzheimer Disease-detect-Nerve Degeneration', 'Hypothermia-show-Edema', 'Hypothermia-show-Inflammation', 'Hypertension-result-Cardiomyopathy, Hypertrophic', 'Hypertension-preceded-Hypotension', 'Obesity-develop-Fatigue', 'Obesity-develop-Dyspnea', 'Obesity-develop-Back Pain', 'Obesity-develop-Arthritis', 'Obesity-increase-Myocardial Infarction', 'Obesity-develop-Sleep Wake Disorders', 'Obesity-develop-Menstruation Disturbances', 'Pelvic Inflammatory Disease-lead-Infertility, Female', 'Dwarfism, Pituitary-lead-Fractures, Bone', 'Dwarfism, Pituitary-lead-Osteoporosis', 'Progeria-characterized-Growth Disorders', 'Sarcopenia-accompanied-Muscular Diseases', 'HIV Infections-affected-Acquired Immunodeficiency Syndrome', 'Joint Diseases-result-Chronic Pain', 'Fibromyalgia-associated-Pain', 'Pain-associated-Fibromyalgia', 'Fibromyalgia-cause-Pain', 'Neoplastic Syndromes, Hereditary-cause-Pain', 'Atherosclerosis-aggravated-Heart Diseases', 'Atherosclerosis-aggravated-Kidney Diseases', 'Ischemia-lead-Infarction', 'Heart Failure, Diastolic-impact-Hypotension', 'Heart Failure, Diastolic-impact-Cardiovascular Diseases', 'Hypotension-impact-Cardiovascular Diseases', 'Heart Failure, Diastolic-tend-Hypertrophy', 'Heart Failure, Diastolic-associated-Pathological Conditions, Anatomical', 'Pathological Conditions, Anatomical-associated-Heart Failure, Diastolic', 'Heart Failure, Diastolic-associated-Ischemia', 'Ischemia-associated-Heart Failure, Diastolic', 'Heart Failure, Diastolic-associated-Tachycardia', 'Tachycardia-associated-Heart Failure, Diastolic', 'Heart Failure, Diastolic-associated-Atrial Fibrillation', 'Atrial Fibrillation-associated-Heart Failure, Diastolic', 'Ventricular Septal Rupture-tend-Infarction', 'Ventricular Septal Rupture-tend-Diabetes Mellitus', 'Ventricular Septal Rupture-occur-Infarction', 'Neoplasms-replace-Hydronephrosis', 'Neoplasms-replace-Lymphatic Diseases', 'Vision Disorders-affected-Cataract', 'Essential Tremor-complicated-Polycythemia Vera', 'Essential Tremor-complicated-Thrombosis', 'Essential Tremor-complicated-Primary Myelofibrosis', 'Polycythemia Vera-complicated-Thrombosis', 'Polycythemia Vera-complicated-Primary Myelofibrosis', 'Essential Tremor-belong-Myeloproliferative Disorders', 'Polycythemia Vera-belong-Myeloproliferative Disorders', 'Colonic Neoplasms-lead-Irritable Bowel Syndrome', 'Essential Tremor-addressed-Thrombosis', 'Polycythemia Vera-addressed-Thrombosis', 'Colonic Neoplasms-result-Leprosy, Tuberculoid', 'Colonic Neoplasms-result-Mitochondrial Diseases', 'Leprosy, Tuberculoid-result-Mitochondrial Diseases', 'Colonic Neoplasms-include-Neuromuscular Diseases', 'Death-increased-Gait Disorders, Neurologic', 'Erectile Dysfunction-affect-Cardiovascular Diseases', 'Sleep Initiation and Maintenance Disorders-caused-Pain', 'Peripheral Vascular Diseases-associated-Erectile Dysfunction', 'Erectile Dysfunction-associated-Peripheral Vascular Diseases', 'Hypotension-understood-Cardiovascular Diseases', 'Heart Failure-shared-Heart Failure, Diastolic', 'Hypertension-reduce-Myocardial Infarction', 'Fibrosis-occur-Jaundice, Chronic Idiopathic', 'Fibrosis-operated-Cholecystitis', 'Atrial Fibrillation-predominate-Stroke', 'Jaundice, Chronic Idiopathic-operated-Cholecystitis', 'Arrhythmias, Cardiac-predominate-Stroke', 'Hepatitis, Viral, Human-associated-Fibrosis', 'Fibrosis-associated-Hepatitis, Viral, Human', 'Cholecystitis-associated-Fibrosis', 'Fibrosis-associated-Cholecystitis', 'Thrombosis-form-Atrial Fibrillation', 'Thrombosis-organize-Atrial Fibrillation', 'Atrial Fibrillation-reported-Atrial Flutter', 'Atrial Fibrillation-provide-Thrombosis', 'Atrial Flutter-provide-Thrombosis', 'Hypertension-correlate-Atherosclerosis', 'Seizures-result-Hypogonadism', 'Epilepsy-result-Seizures', 'Seizures-result-Hypothalamic Neoplasms', 'Neoplasms-benefit-Carcinogenesis', 'Hallucinations-reduce-Parkinson Disease', 'Colorectal Neoplasms-occur-Neoplasms', 'Anemia, Megaloblastic-known-Immunologic Deficiency Syndromes', 'Parkinson Disease-show-Alzheimer Disease', 'Retinal Degeneration-cause-Dementia', 'Drug Overdose-see-Death', 'Death-computed-Neoplasms', 'Hypogonadism-underlie-Testicular Diseases', 'Fatigue-include-Frailty', 'Osteoporosis-include-Frailty', 'Breast Neoplasms, Male-include-Cardiac Output, Low', 'Breast Neoplasms, Male-fall-Cardiac Output, Low', 'Breast Neoplasms, Male-include-Memory Disorders', 'Cardiac Output, Low-fall-Memory Disorders', 'Hemiplegia-develop-Cerebral Infarction', 'Hemianopsia-develop-Cerebral Infarction', 'Pain-treat-Diarrhea', 'Hypokinesia-associated-Dementia', 'Dementia-associated-Hypokinesia', 'Tremor-analyzed-Immunologic Deficiency Syndromes', 'Muscle Rigidity-analyzed-Immunologic Deficiency Syndromes', 'Disease-cause-Pain', 'Hypokinesia-analyzed-Immunologic Deficiency Syndromes', 'Pain-ascribed-Osteoarthritis', 'Pain-ascribed-Chondromalacia Patellae', 'Hypertension-evidence-Death', 'Dermatitis, Atopic-increase-Niemann-Pick Disease, Type A', 'Dermatitis-show-Niemann-Pick Disease, Type A', 'Niemann-Pick Disease, Type A-associated-Dermatitis, Atopic', 'Dermatitis, Atopic-associated-Niemann-Pick Disease, Type A', 'Neoplasms-develop-Sarcoma', 'Breast Neoplasms-carry-Neoplasms', 'Neoplasms-develop-Lymphoma', 'Neurologic Manifestations-observed-Hypercholesterolemia', 'Neurologic Manifestations-observed-Hyperhomocysteinemia', 'Hypoalbuminemia-slow-Kidney Failure, Chronic', 'Neurologic Manifestations-observed-Hypertension', 'Neurologic Manifestations-observed-Diabetes Mellitus', 'Retinal Diseases-caused-Chemical and Drug Induced Liver Injury', 'Atrioventricular Block-treated-Sick Sinus Syndrome', 'Muscular Disorders, Atrophic-investigated-Atrioventricular Block', 'Muscular Disorders, Atrophic-investigated-Sick Sinus Syndrome', 'Skin Diseases-hear-Hearing Loss', 'Pemphigus, Benign Familial-hear-Hearing Loss', 'Migraine with Aura-play-Lambert-Eaton Myasthenic Syndrome', 'Epilepsy-play-Lambert-Eaton Myasthenic Syndrome', 'Osteomalacia-mimic-Osteoporosis', 'Hyperparathyroidism-mimic-Osteoporosis', 'Immunologic Deficiency Syndromes-associated-Hereditary Breast and Ovarian Cancer Syndrome', 'Hereditary Breast and Ovarian Cancer Syndrome-associated-Immunologic Deficiency Syndromes', 'Neoplasms-disclose-Alzheimer Disease', 'Proteinuria-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-Proteinuria', 'Epilepsy, Tonic-Clonic-treat-Heart Failure, Diastolic', 'Epilepsy, Tonic-Clonic-treat-Heart Failure', 'Heart Diseases-result-Atrial Fibrillation', 'Heart Failure-aggravated-Atrial Fibrillation', 'Arrhythmias, Cardiac-cause-Atrial Fibrillation', 'Atrial Fibrillation-associated-Dyspnea', 'Dyspnea-associated-Atrial Fibrillation', 'Atrial Fibrillation-seen-Arrhythmias, Cardiac', 'Atrial Fibrillation-associated-Fatigue', 'Fatigue-associated-Atrial Fibrillation', 'Atrial Fibrillation-associated-Syncope', 'Syncope-associated-Atrial Fibrillation', 'Parkinson Disease-characterized-Death', 'Pneumonia-link-Heart Arrest', 'Dementia-correlate-Alzheimer Disease', 'Dementia-correlate-Plaque, Amyloid', 'Hyperoxia-cause-Heart Arrest', 'Hypotension-tried-Hypertension', 'Myocardial Infarction-identify-Intracranial Hemorrhages', 'Syncope-viewed-Seizures', 'Hypertension-reduce-Cardiomyopathy, Hypertrophic', 'Kidney Diseases-include-Hypertension', 'Metabolic Syndrome-treated-Hypertension', 'Atherosclerosis-develop-Hyperhomocysteinemia', 'Liver Failure-include-Heart Failure', 'Delirium-include-Heart Failure', 'Dementia-include-Heart Failure', 'Hypotension-include-Heart Failure', 'Heart Failure-applied-Cardiovascular Diseases', 'Urinary Incontinence-include-Heart Failure', 'Sleep Deprivation-include-Heart Failure', 'Heart Failure-caused-Heart Valve Diseases', 'Heart Failure-caused-Kidney Diseases', 'Arrhythmias, Cardiac-include-Heart Failure', 'Atrial Fibrillation-treated-Stroke', 'Ventricular Fibrillation-include-Heart Failure', 'Bradycardia-include-Heart Failure', 'Arrhythmias, Cardiac-survive-Peri-Implantitis', 'Arrhythmias, Cardiac-survive-Heart Failure', 'Coronary Artery Disease-improve-Peri-Implantitis', 'Coronary Artery Disease-induced-Arrhythmias, Cardiac', 'Tachycardia, Ventricular-improve-Peri-Implantitis', 'Tachycardia, Ventricular-induced-Arrhythmias, Cardiac', 'Peri-Implantitis-induced-Arrhythmias, Cardiac', 'Arrhythmias, Cardiac-underlie-Cardiovascular Abnormalities', 'Hypertrophy-include-Heart Failure, Diastolic', 'Heart Failure-differentiated-Heart Failure, Diastolic', 'Fatigue-alleviate-Fever', 'Fatigue-alleviate-Dyspnea', 'Spinal Cord Injuries-administered-Brain Injuries, Traumatic', 'Opportunistic Infections-represent-Spinal Cord Injuries', 'Fever-contribute-Death', 'Fever-contribute-Infections', 'Fever-associated-Bacterial Infections', 'Bacterial Infections-associated-Fever', 'Ischemia-account-Death', 'Angina Pectoris-reflect-Coronary Artery Disease', 'Myocardial Infarction-reflect-Coronary Artery Disease', 'Arrhythmias, Cardiac-reflect-Coronary Artery Disease', 'Genetic Diseases, Inborn-known-Werner Syndrome', 'Alzheimer Disease-evaluated-Dementia', 'Hyperparathyroidism-detected-Bone Diseases', 'Arrhythmias, Cardiac-followed-Pneumonia', 'Craniocerebral Trauma-do-Coma', 'Teratoma-found-Neoplasms', 'Neoplasms-show-Aneuploidy', 'Fractures, Bone-develop-Osteoporosis', 'Death-attributed-Cerebrovascular Disorders', 'Cerebral Infarction-lead-Brain Damage, Chronic', 'Cerebral Infarction-result-Dementia, Vascular', 'Brain Damage, Chronic-result-Dementia, Vascular', 'Cerebral Infarction-observed-Embolism', 'Cerebral Infarction-observed-Atherosclerosis', 'Spinal Injuries-include-Vasculitis', 'Gout-associated-Kidney Diseases', 'Kidney Diseases-associated-Gout', 'Gallbladder Neoplasms-identify-Neoplasms', 'Bone Neoplasms-include-Weight Loss', 'Pain-precede-Drug Eruptions', 'Werner Syndrome-exhibit-Neoplasms', 'Gangrene-complicate-Appendicitis', 'Genetic Diseases, Inborn-exhibit-Neoplasms', 'Aneuploidy-found-Werner Syndrome', 'Eosinophilia-associated-Asthma', 'Asthma-associated-Eosinophilia', 'Ocular Hypertension-refer-Eye Diseases', 'Candidiasis, Oral-associated-Mastocytosis, Systemic', 'Mastocytosis, Systemic-associated-Candidiasis, Oral', 'Communicable Diseases-become-Infections', 'Peripheral Vascular Diseases-undergo-Neoplasms', 'Death-correspond-Wounds and Injuries', 'Infections-result-Opportunistic Infections', 'Lymphopenia-induced-Arbovirus Infections', 'Giant Cell Arteritis-associated-Aortic Aneurysm', 'Aortic Aneurysm-associated-Giant Cell Arteritis', 'Giant Cell Arteritis-associated-Rupture', 'Rupture-associated-Giant Cell Arteritis', 'Kidney Failure, Chronic-develop-Rhabdomyolysis', 'Syncope-diagnosed-Syncope, Vasovagal', 'Death-lapse-Coma', 'Atrial Fibrillation-develop-Hemorrhage', 'Hypotension-reduce-Stroke', 'Heart Failure, Diastolic-reduce-Stroke', 'Renal Insufficiency-make-Drug-Related Side Effects and Adverse Reactions', 'Chest Pain-complicated-Heart Failure', 'Hip Dislocation-develop-Pain', 'Thrombocytosis-treat-Optic Neuropathy, Ischemic', 'Werner Syndrome-include-Genetic Diseases, Inborn', 'Heart Failure-dispelled-Hypertension', 'Heart Failure-dispelled-Cardiomyopathy, Hypertrophic', 'Heart Failure-dispelled-Dyslipidemias', 'Heart Failure-dispelled-Atrial Fibrillation', 'Drug-Related Side Effects and Adverse Reactions-perform-Carcinoma, Non-Small-Cell Lung', 'Myositis-distinguish-Muscular Diseases', 'Obesity-associated-Movement Disorders', 'Movement Disorders-associated-Obesity', 'Brain Diseases-form-Neurodegenerative Diseases', 'Central Nervous System Vascular Malformations-form-Neurodegenerative Diseases', 'Nerve Degeneration-form-Neurodegenerative Diseases', 'Movement Disorders-develop-Cardiovascular Diseases', 'Heart Diseases-reflect-Heart Failure', 'Heart Failure-reflect-Aneurysm', 'Heart Failure-found-Aneurysm', 'Rupture-cause-Thrombosis', 'Stroke-occur-Alzheimer Disease', 'Stroke-underlie-Alzheimer Disease', 'Stroke-promote-Brain Ischemia', 'Alzheimer Disease-promote-Brain Ischemia', 'Brain Ischemia-promote-Alzheimer Disease', 'Aortic Aneurysm, Abdominal-contribute-Aneurysm', 'Atherosclerosis-result-Ischemia', 'Atherosclerosis-result-Kidney Diseases', 'Diabetes Mellitus-predispose-Communicable Diseases', 'Dyslipidemias-predispose-Communicable Diseases', 'Peripheral Arterial Disease-define-Diabetes Mellitus', 'Diabetes Mellitus-cross-categorized-Peripheral Arterial Disease', 'Tachycardia, Sinus-lead-Bundle-Branch Block', 'Osteoarthritis-result-Edema', 'Osteoarthritis-result-Joint Diseases', 'Cardiovascular Diseases-include-Myocardial Infarction', 'Blindness-include-Retinal Diseases', 'Parkinson Disease-reflect-Death', 'Prostatic Neoplasms-correlate-Neoplasms', 'Seminoma-followed-Neoplasms', 'Hemorrhage-cause-Obesity', 'Endometrial Hyperplasia-cause-Obesity', 'Neoplasms-cause-Obesity', 'Alzheimer Disease-consist-Atrophy', 'Alzheimer Disease-consist-Neurodegenerative Diseases', 'Dementia-name-Amnesia', 'Sleep Wake Disorders-treat-Nervous System Diseases', 'Prostatic Neoplasms-reveal-Prostatitis', 'Cardiovascular Diseases-develop-Hypertension', 'Chronic Disease-characterized-Dementia', 'Chronic Disease-characterized-Death', 'Polyuria-alleviated-Nocturia', 'Polyuria-associated-Hypertension', 'Hypertension-associated-Polyuria', 'Hypertension-underlie-Death', 'Coronary Artery Disease-underlie-Death', 'Heart Failure-underlie-Death', 'Cerebrovascular Disorders-underlie-Death', 'Cough-support-Respiratory Insufficiency', 'Williams Syndrome-associated-Neoplasms', 'Neoplasms-associated-Williams Syndrome', 'Heart Failure-lead-Hypotension', 'Heart Failure, Diastolic-lead-Hypotension', 'Lung Diseases-lead-Respiratory Insufficiency', 'Cough-lead-Respiratory Insufficiency', 'Pneumonia-lead-Respiratory Insufficiency', 'Graft vs Host Disease-correct-Immunologic Deficiency Syndromes', 'Immunologic Deficiency Syndromes-cure-Anemia, Aplastic', 'Autoimmune Diseases-produce-Tay-Sachs Disease', 'HIV Infections-made-Pneumonia, Pneumocystis', 'Myositis-associated-Arbovirus Infections', 'Arbovirus Infections-associated-Myositis', 'Musculoskeletal Diseases-prevent-Hypertension, Pulmonary', 'Diverticulitis-associated-Death', 'Death-associated-Diverticulitis', 'Arthralgia-include-Osteoarthritis', 'Hypertension-constitute-Cardiovascular Diseases', 'Chronic Disease-associated-Muscle Weakness', 'Muscle Weakness-associated-Chronic Disease', 'Nervous System Diseases-associated-Muscle Weakness', 'Muscle Weakness-associated-Nervous System Diseases', 'Arrhythmias, Cardiac-suffer-Urinary Incontinence', 'Arrhythmias, Cardiac-suffer-Urinary Incontinence, Stress', 'Arrhythmias, Cardiac-reported-Urinary Incontinence', 'Urinary Incontinence-related-Wounds and Injuries', 'Urinary Incontinence-include-Wounds and Injuries', 'Wounds and Injuries-include-Urinary Incontinence', 'Gangrene-occur-Hypotension', 'Drug Resistant Epilepsy-prevent-Infections', 'Pneumonia-increase-Heart Diseases', 'Heart Block-include-Atrioventricular Block', 'Ulcer-help-Signs and Symptoms, Digestive', 'Acute Disease-help-Signs and Symptoms, Digestive', 'Cerebrovascular Disorders-accompany-Stroke', 'Immunologic Deficiency Syndromes-associated-Tuberculosis, Meningeal', 'Tuberculosis, Meningeal-associated-Immunologic Deficiency Syndromes', 'Cerebral Amyloid Angiopathy-associated-Amyloidosis', 'Amyloidosis-associated-Cerebral Amyloid Angiopathy', 'Osteoporotic Fractures-associate-Death', 'Death-associate-Osteoporotic Fractures', 'Osteoporosis-used-Immunologic Deficiency Syndromes', 'Fractures, Bone-caused-Immunologic Deficiency Syndromes', 'Aortic Diseases-pallor-Ischemia', 'Aortic Diseases-increase-Dementia', 'Alzheimer Disease-predispose-Cerebral Amyloid Angiopathy', 'Alzheimer Disease-predispose-Coronary Artery Disease', 'Alzheimer Disease-predispose-Cerebrovascular Disorders', 'Hemorrhage-implicated-Cerebral Amyloid Angiopathy', 'Cerebral Amyloid Angiopathy-implicated-Infarction', 'Cerebral Amyloid Angiopathy-produce-Aneurysm', 'Cerebral Amyloid Angiopathy-produce-Alzheimer Disease', 'Aneurysm-found-Alzheimer Disease', 'Dementia, Vascular-explain-Alzheimer Disease', 'Cerebrovascular Disorders-evolve-Aortic Diseases', 'Neurodegenerative Diseases-express-Alzheimer Disease', 'Inflammation-found-Leukoaraiosis', 'Leukoencephalopathies-known-Leukoaraiosis', 'Leukoencephalopathies-known-Ischemia', 'Hypokalemia-associated-Hypertension', 'Hypertension-associated-Hypokalemia', 'Hypokalemia-experience-Stroke', 'Plaque, Atherosclerotic-known-Arteriosclerosis', 'Headache-occur-Disorders of Excessive Somnolence', 'Headache-occur-Diarrhea', 'Headache-occur-Constipation', 'Sleep Initiation and Maintenance Disorders-occur-Disorders of Excessive Somnolence', 'Sleep Initiation and Maintenance Disorders-occur-Diarrhea', 'Sleep Initiation and Maintenance Disorders-occur-Constipation', 'Xerostomia-occur-Disorders of Excessive Somnolence', 'Xerostomia-occur-Diarrhea', 'Xerostomia-occur-Constipation', 'Hypertension-represent-Renal Artery Obstruction', 'Psychomotor Agitation-occur-Disorders of Excessive Somnolence', 'Psychomotor Agitation-occur-Diarrhea', 'Psychomotor Agitation-occur-Constipation', 'Infections-associated-Hematuria', 'Hematuria-associated-Infections', 'Hepatomegaly-tend-Infections', 'Splenomegaly-tend-Infections', 'Urinary Bladder Diseases-correlate-Hematuria', 'Urinary Bladder Diseases-correlate-Proteinuria', 'Hepatomegaly-associated-Schistosomiasis japonica', 'Schistosomiasis japonica-associated-Hepatomegaly', 'Schistosomiasis-suppress-Infections', 'Splenomegaly-associated-Schistosomiasis japonica', 'Schistosomiasis japonica-associated-Splenomegaly', 'Splenomegaly-associated-Infections', 'Infections-associated-Splenomegaly', 'Hepatomegaly-associated-Infections', 'Infections-associated-Hepatomegaly', 'Schistosomiasis japonica-associated-Infections', 'Infections-associated-Schistosomiasis japonica', 'Hepatomegaly-detected-Splenomegaly', 'Prostatic Neoplasms-examined-Alopecia', 'Polymyositis-define-Dermatomyositis', 'Prostatic Neoplasms-identified-Death', 'Colorectal Neoplasms-arise-Adenomatous Polyps', 'Psychoses, Substance-Induced-diagnosed-Hallucinations', 'Parkinson Disease-correlated-Dementia', 'Dementia-correlated-Psychoses, Substance-Induced', 'Sleep Initiation and Maintenance Disorders-tolerated-Nausea', 'Death-reduce-Heart Arrest', 'Kidney Diseases-required-Hypotension', 'Neoplasms-contribute-Myelodysplastic Syndromes', 'Hypertension-associated-Cardiomyopathy, Dilated', 'Cardiomyopathy, Dilated-associated-Hypertension', 'Hypertension-associated-Ventricular Fibrillation', 'Ventricular Fibrillation-associated-Hypertension', 'Thoracic Diseases-avoid-Death', 'Aortic Diseases-associated-Wounds and Injuries', 'Wounds and Injuries-associated-Aortic Diseases', 'Parkinson Disease, Secondary-determined-Dementia', 'Parkinson Disease, Secondary-conducted-Alzheimer Disease', 'Parkinson Disease, Secondary-associate-Death', 'Death-associate-Parkinson Disease, Secondary', 'Parkinson Disease, Secondary-associate-Alzheimer Disease', 'Alzheimer Disease-associate-Parkinson Disease, Secondary', 'Alzheimer Disease-remain-Parkinson Disease, Secondary', 'Arthritis-followed-Fractures, Bone', 'Pain-identify-Fatigue', 'Deglutition Disorders-cause-Airway Obstruction', 'Epilepsy-occur-Cerebrovascular Disorders', 'Hemorrhage-combined-Pain', 'Pain-combined-Dyspepsia', 'Choroidal Neovascularization-complicated-Blindness', 'Diabetes Mellitus-treated-Carcinoid Tumor', 'Muscle Weakness-attributed-Diabetic Neuropathies', 'Weight Loss-include-Bone Neoplasms', 'Respiratory Tract Infections-associated-Kidney Diseases', 'Kidney Diseases-associated-Respiratory Tract Infections', 'Death-compare-Pneumonia', 'Pneumonia, Pneumocystis-reduce-Death', 'Pneumonia, Pneumocystis-reduce-Infections', 'Tuberculosis-reduce-Infections', 'Pneumonia-observed-Blister', 'Pneumonia-observed-Pleural Effusion', 'Liver Cirrhosis-occur-Hepatitis B', 'Diabetes Mellitus-lead-Fibrosis', 'Hepatitis-lead-Fibrosis', 'Fibrosis-develop-Diabetes Mellitus', 'Diabetes Mellitus-play-Liver Cirrhosis', 'Cerebrovascular Disorders-found-Sleep Deprivation', 'Wounds and Injuries-lagge-Infections', 'Smoke Inhalation Injury-lead-Death', 'Ovarian Neoplasms-transmit-Genetic Diseases, Inborn', 'Critical Illness-seen-Sepsis', 'Critical Illness-seen-Wounds and Injuries', 'Critical Illness-remain-Death', 'Pheochromocytoma-cause-Hypertension', 'Alkaptonuria-develop-Arthritis', 'Pheochromocytoma-cause-Cardiovascular Diseases', 'Alkaptonuria-suffer-Cardiovascular Diseases', 'Alkaptonuria-suffer-Death', 'Pheochromocytoma-cause-Death', 'Alkaptonuria-suffer-Kidney Diseases', 'Pheochromocytoma-cause-Kidney Diseases', 'Arthritis-suffer-Cardiovascular Diseases', 'Pheochromocytoma-cause-Stroke', 'Arthritis-suffer-Death', 'Pheochromocytoma-cause-Neoplasms', 'Pheochromocytoma-cause-Pancreatitis', 'Arthritis-suffer-Kidney Diseases', 'Pheochromocytoma-cause-Carcinoid Tumor', 'Pheochromocytoma-cause-Neuroblastoma', 'Pheochromocytoma-cause-Hypercalcemia', 'Pheochromocytoma-cause-Aneurysm', 'Pheochromocytoma-mimic-Diabetes Mellitus', 'Wounds and Injuries-experience-Inflammation', 'Pigmentation Disorders-experience-Inflammation', 'Death-cause-Pancreatitis', 'Death-cause-Carcinoid Tumor', 'Death-cause-Neuroblastoma', 'Death-cause-Hypercalcemia', 'Death-cause-Aneurysm', 'Death-mimic-Diabetes Mellitus', 'Leukoaraiosis-associated-Alzheimer Disease', 'Alzheimer Disease-associated-Leukoaraiosis', 'Brain Ischemia-associated-Alzheimer Disease', 'Alzheimer Disease-associated-Brain Ischemia', 'Uremia-produced-Diabetes Mellitus', 'Hypertension-increase-Seizures', 'Death-exerted-Pulmonary Disease, Chronic Obstructive', 'Death-exerted-Hypertension', 'Death-exerted-Pleural Diseases', 'Urinary Incontinence-increase-Cystitis', 'Heart Block-inhibit-Dyskinesia, Drug-Induced', 'Heart Block-lead-Brain Diseases, Metabolic', 'Dyskinesia, Drug-Induced-lead-Brain Diseases, Metabolic', 'Hip Fractures-hospitalized-Neoplasms', 'Hip Fractures-hospitalized-Wounds and Injuries', 'Seizures-prevent-Chronic Disease', 'Acute Disease-worsen-Heart Failure', 'Nervous System Diseases-diagnosed-Diabetes Mellitus', 'Nervous System Diseases-diagnosed-Amyloid Neuropathies', 'Polyneuropathies-considered-Nervous System Diseases', 'Polyneuropathies-considered-Pain', 'Nervous System Diseases-considered-Pain', 'Heart Failure-distinguish-Atrophy', 'Fractures, Bone-induced-Osteoporosis', 'Bone Neoplasms-induced-Osteoporosis', 'Hyperparathyroidism, Secondary-offset-Hypercalcemia', 'Hyperparathyroidism, Secondary-offset-Osteoporosis', 'Hyperparathyroidism, Secondary-cause-Osteoporosis', 'Hypercalcemia-cause-Osteoporosis', 'Death-shifted-Chronic Disease', 'Respiratory Tract Diseases-account-Death', 'Dysentery-include-Communicable Diseases', 'Paratyphoid Fever-include-Communicable Diseases', 'Pulmonary Disease, Chronic Obstructive-followed-Heart Diseases', 'Cough-include-Communicable Diseases', 'Pulmonary Disease, Chronic Obstructive-followed-Neoplasms', 'Osteomyelitis-occur-Mesenteric Ischemia', 'Osteomyelitis-occur-Diabetes Mellitus', 'Osteomyelitis-occur-Peripheral Vascular Diseases', 'Osteomyelitis-occur-Atherosclerosis', 'Heart Failure-activated-Cardiomyopathies', 'Arthritis-reduce-Diabetes Mellitus', 'Arthritis-improve-Coronary Artery Disease', 'Colitis-differentiated-Inflammatory Bowel Diseases', 'Infections-indicate-Inflammatory Bowel Diseases', 'Coronary Artery Disease-investigate-Erectile Dysfunction', 'Coronary Artery Disease-investigate-Vertebrobasilar Insufficiency', 'Coronary Artery Disease-manifested-Vertebrobasilar Insufficiency', 'Erectile Dysfunction-investigate-Vertebrobasilar Insufficiency', 'Erectile Dysfunction-manifested-Vertebrobasilar Insufficiency', 'Erectile Dysfunction-serve-Coronary Artery Disease', 'Heart Failure, Diastolic-seen-Hypertension', 'Heart Failure, Diastolic-seen-Heart Valve Diseases', 'Heart Failure, Diastolic-seen-Hypertrophy', 'Heart Failure, Diastolic-seen-Cardiomyopathies', 'Heart Failure, Diastolic-occur-Tachycardia', 'Heart Failure, Diastolic-occur-Ischemia', 'Hyperopia-start-Myopia', 'Shock-related-Death', 'Shock-seem-Death', 'Shock-show-Death', 'Neoplasms-obtained-Death', 'Seizures-exert-Cardiovascular Diseases', 'Alzheimer Disease-play-Dementia', 'Alzheimer Disease-play-Stroke', 'Dementia-play-Stroke', 'Renal Insufficiency-associated-Ischemia', 'Ischemia-associated-Renal Insufficiency', 'Stroke-play-Atherosclerosis', 'Diarrhea-contract-Infections', 'Immunologic Deficiency Syndromes-contract-Infections', 'Communicable Diseases-classified-Diarrhea', 'Muscular Dystrophies-caused-Wounds and Injuries', 'Angina Pectoris-associated-Myocardial Infarction', 'Myocardial Infarction-associated-Angina Pectoris', 'Hypercholesterolemia-related-Myocardial Infarction', 'Diarrhea-affect-Ocular Motility Disorders', 'Immunologic Deficiency Syndromes-incriminated-Osteoporosis', 'End Stage Liver Disease-related-Hepatitis C', 'Massive Hepatic Necrosis-occur-End Stage Liver Disease', 'Hepatitis, Viral, Human-underlie-Hepatitis C', 'Death-compared-Urinary Tract Infections', 'Hearing Loss-result-Tinnitus', 'Scabies-affect-Lice Infestations', 'Pulmonary Disease, Chronic Obstructive-associated-Anorexia', 'Anorexia-associated-Pulmonary Disease, Chronic Obstructive', 'Atrophy-enhanced-Fractures, Bone', 'Asthma-mimic-Bronchitis', 'Drug-Related Side Effects and Adverse Reactions-consist-Esophageal Neoplasms', 'Pneumonia, Pneumocystis-include-HIV Infections', 'Tuberculosis-include-HIV Infections', 'AIDS Dementia Complex-include-HIV Infections', 'Pneumonia, Pneumocystis-include-Acquired Immunodeficiency Syndrome', 'Tuberculosis-include-Acquired Immunodeficiency Syndrome', 'AIDS Dementia Complex-include-Acquired Immunodeficiency Syndrome', 'Atherosclerosis-defined-Coronary Artery Disease', 'Atherosclerosis-defined-Peripheral Vascular Diseases', 'Atherosclerosis-defined-Stroke', 'Atherosclerosis-defined-Aneurysm', 'Ischemia-considered-Thromboangiitis Obliterans', 'Thrombophlebitis-considered-Thromboangiitis Obliterans', 'Thromboangiitis Obliterans-affect-Thrombophlebitis', 'Thrombophlebitis-affect-Raynaud Disease', 'Memory Disorders-appear-Alzheimer Disease', 'Hyperkinesis-cause-Paralysis', 'Stomach Neoplasms-hospitalized-Ulcer', 'Sleep-Wake Transition Disorders-associated-Peripheral Vascular Diseases', 'Peripheral Vascular Diseases-associated-Sleep-Wake Transition Disorders', 'Sleep-Wake Transition Disorders-associated-Arthritis', 'Arthritis-associated-Sleep-Wake Transition Disorders', 'Kidney Diseases-increase-Glomerulonephritis', 'Nephrosclerosis-show-Acute Kidney Injury', 'Atherosclerosis-accelerate-Blood Platelet Disorders', 'Renal Insufficiency-accumulate-Cardiac Output, Low', 'Renal Insufficiency-accumulate-Uremia', 'Nervous System Diseases-delay-Retinal Diseases', 'Nervous System Diseases-delay-Kidney Diseases', 'Cerebral Infarction-divided-Infarction', 'Infarction-associated-Pneumonia', 'Pneumonia-associated-Infarction', 'Leukemia, Myeloid, Acute-show-Leukopenia', 'Leukemia, Myeloid, Acute-show-Anemia', 'Cockayne Syndrome-associated-Ichthyosis', 'Ichthyosis-associated-Cockayne Syndrome', 'Ulcer-become-Infections', 'Ulcer-infect-Infections', 'Death-rank-Coronary Artery Disease', 'Trigeminal Neuralgia-affect-Facial Pain', 'Trigeminal Neuralgia-review-Pain', 'Prostatic Neoplasms-stimulate-Neoplasms', 'Facial Pain-treat-Neuralgia', 'Immunologic Deficiency Syndromes-associated-Osteoporosis', 'Osteoporosis-associated-Immunologic Deficiency Syndromes', 'Neurodegenerative Diseases-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-Neurodegenerative Diseases', 'Neurodegenerative Diseases-associated-Osteoporosis', 'Osteoporosis-associated-Neurodegenerative Diseases', 'Gastroesophageal Reflux-include-Hernia, Hiatal', 'Gastroesophageal Reflux-include-Ocular Motility Disorders', 'Heart Failure-increased-Sleep Wake Disorders', 'Alzheimer Disease-linked-Mitochondrial Diseases', 'Sleep Wake Disorders-identify-Death', 'Thyroid Diseases-reported-Spinal Cord Injuries', 'Tuberculosis, Pulmonary-account-Death', 'Adrenocortical Carcinoma-present-Virilism', 'Adrenocortical Carcinoma-lead-Death', 'Virilism-lead-Death', 'Rothmund-Thomson Syndrome-develop-Osteosarcoma', 'Rothmund-Thomson Syndrome-comprise-Growth Disorders', 'Hyperparathyroidism-accelerate-Bone Neoplasms', 'Genetic Diseases, Inborn-comprise-Rothmund-Thomson Syndrome', 'Hyperparathyroidism-increase-Hip Fractures', 'Genetic Diseases, Inborn-comprise-Growth Disorders', 'Bone Neoplasms-increase-Hip Fractures', 'Pulmonary Disease, Chronic Obstructive-impart-Death', 'Kidney Failure, Chronic-expect-Death', 'Diabetes Mellitus, Type 2-emerge-Death', 'Immunologic Deficiency Syndromes-decrease-Cardiac Output, Low', 'Hyperthyroidism-occur-Nervous System Diseases', 'Immunologic Deficiency Syndromes-affect-Brain Damage, Chronic', 'Immunologic Deficiency Syndromes-affect-Intellectual Disability', 'Atrophy-accentuated-Alzheimer Disease', 'Death-fall-Cardiovascular Diseases', 'Stroke-increase-Neoplasms', 'Cough-followed-Dyspnea', 'Headache Disorders, Secondary-regarded-Infections', 'Dysuria-seen-Infections', 'Dysuria-used-Pyuria', 'Infections-used-Pyuria', 'Dementia-segregate-Intellectual Disability', 'Dementia-underlie-Intellectual Disability', 'Ovarian Neoplasms-follow-Breast Neoplasms', 'Ovarian Neoplasms-follow-Neoplasms', 'Neoplasms-rank-Colonic Neoplasms', 'Neoplasms-rank-Rectal Neoplasms', 'Colonic Neoplasms-rank-Breast Neoplasms', 'Ventricular Fibrillation-develop-Osteoarthritis', 'Breast Neoplasms-rank-Rectal Neoplasms', 'Urinary Incontinence-help-Vision Disorders', 'Urinary Incontinence-help-Hearing Loss', 'Iliotibial Band Syndrome-noted-Alzheimer Disease', 'Inflammation-associated-Dementia, Vascular', 'Dementia, Vascular-associated-Inflammation', 'Hypothalamic Neoplasms-suggest-Hypothyroidism', 'Dyslipidemias-associated-Hyperglycemia', 'Hyperglycemia-associated-Dyslipidemias', 'Metabolic Diseases-regulate-Cardiovascular Diseases', 'Rotavirus Infections-associate-Signs and Symptoms, Digestive', 'Signs and Symptoms, Digestive-associate-Rotavirus Infections', 'Infections-associate-Signs and Symptoms, Digestive', 'Signs and Symptoms, Digestive-associate-Infections', 'Hemorrhage-stop-Gastric Outlet Obstruction', 'Hemolytic-Uremic Syndrome-develop-Coronary Artery Disease', 'Hemolytic-Uremic Syndrome-develop-Death, Sudden', 'Hemolytic-Uremic Syndrome-develop-Aneurysm', 'Hemolytic-Uremic Syndrome-develop-Heart Failure', 'Atherosclerosis-assessed-Leukoencephalopathies', 'Atherosclerosis-characterized-Hypertrophy', 'Death-cause-Thyroid Neoplasms', 'Thyroid Neoplasms-follow-Neoplasms', 'Plaque, Atherosclerotic-associated-Stroke', 'Stroke-associated-Plaque, Atherosclerotic', 'Chronic Disease-obtained-Neoplasms', 'Kidney Diseases-contribute-Acute Kidney Injury', 'Kidney Diseases-contribute-Sepsis', 'Hypotension-recorded-Shock', 'Acidosis-observed-Hypothermia', 'Polycystic Ovary Syndrome-signal-Infertility, Female', 'Heart Failure-investigated-Metabolic Diseases', 'Heart Failure-regarded-Metabolic Diseases', 'Neurodegenerative Diseases-influenced-Heart Arrest', 'Neurodegenerative Diseases-influenced-Diabetes Mellitus', 'Neurodegenerative Diseases-influenced-Obesity', 'Muscle Hypotonia-caused-Peripheral Nervous System Diseases', 'Muscle Hypotonia-caused-Spinal Cord Diseases', 'Urinary Tract Infections-related-Critical Illness', 'Spinal Fractures-take-Hip Fractures', 'Pain-take-Hip Fractures', 'Memory Disorders-impair-Sleep Initiation and Maintenance Disorders', 'Memory Disorders-impair-Myalgia', 'Memory Disorders-impair-Sexual Dysfunction, Physiological', 'Sleep Initiation and Maintenance Disorders-concentrate-Myalgia', 'Sleep Initiation and Maintenance Disorders-concentrate-Sexual Dysfunction, Physiological', 'Pneumonia-result-Fractures, Bone', 'Infections-evolve-Fibrosis', 'Muscular Dystrophy, Duchenne-preserve-Muscular Diseases', 'Muscular Diseases-preserve-Hip Fractures', 'Ulcer-acquire-Infections', 'Hypotension-experience-Sleep Initiation and Maintenance Disorders', 'Cardiovascular Diseases-experience-Sleep Initiation and Maintenance Disorders', 'Brain Damage, Chronic-associated-Dementia', 'Dementia-associated-Brain Damage, Chronic', "Corneal Diseases-elevate-Fuchs' Endothelial Dystrophy", "Ocular Hypertension-elevate-Fuchs' Endothelial Dystrophy", 'Obesity-used-Arthralgia', 'Obesity-predict-Arthralgia', 'Obesity-report-Arthralgia', 'Kidney Failure, Chronic-caused-Cerebrovascular Disorders', 'Hypertension-caused-Death', 'Diabetes Mellitus-caused-Death', 'Coronary Artery Disease-prevent-Death', 'Hyperinsulinism-occur-Glucose Intolerance', 'Escherichia coli Infections-prevent-Infections', 'Diarrhea-prevent-Infections', 'Stroke-cause-Myocardial Infarction', 'Stroke-cause-Death, Sudden', 'Death, Sudden-include-Myocardial Infarction', 'Respiratory Insufficiency-require-Renal Insufficiency', 'Renal Insufficiency-require-Hemorrhage', 'Abnormalities, Drug-Induced-provide-Heart Diseases', 'Heart Failure-cause-Anemia, Hemolytic', 'Spondylitis-involve-Sacroiliitis', 'Colonic Neoplasms-used-Constipation', 'Death-slow-Cardiomyopathies', 'Syncope-occur-Sick Sinus Syndrome', 'Flushing-occur-Sick Sinus Syndrome', 'Werner Syndrome-result-Sotos Syndrome', 'Death-increase-Delirium', 'White Coat Hypertension-known-Hypertension', 'White Coat Hypertension-predispose-Hypertension', 'Cardiovascular Diseases-account-Hypertension', 'Cardiovascular Diseases-become-Seizures', 'Cardiovascular Diseases-modify-Seizures', 'Intracranial Hemorrhages-associated-Hemorrhage', 'Hemorrhage-associated-Intracranial Hemorrhages', 'Kidney Diseases-slow-Diabetes Mellitus', 'Renal Insufficiency-prevent-Hypertension', 'Renal Insufficiency-slow-Diabetes Mellitus', 'Hypertension-slow-Diabetes Mellitus', 'Lacrimal Apparatus Diseases-create-Musculoskeletal Diseases', 'Hyperthyroidism-longstand-Congenital Hypothyroidism', 'Cardiovascular Diseases-connote-Congenital Hyperinsulinism', 'Cardiovascular Diseases-connote-Obesity', 'Tetany-distinguish-Hyperparathyroidism, Primary', 'Fat Necrosis-associated-Neoplasms', 'Neoplasms-associated-Fat Necrosis', 'Fat Necrosis-associated-Breast Neoplasms', 'Breast Neoplasms-associated-Fat Necrosis', 'Neoplasms-protected-Obesity', 'Atherosclerosis-begin-Death', 'Atherosclerosis-perform-Coronary Artery Disease', 'Mycoses-receive-Neoplasms', 'Abdominal Pain-associated-Diarrhea', 'Diarrhea-associated-Abdominal Pain', 'Infections-triggered-Nervous System Diseases', 'Retinal Neovascularization-progress-Blindness', 'Disorders of Excessive Somnolence-collected-Parkinson Disease', 'Disorders of Excessive Somnolence-compared-Diabetes Mellitus', 'Parkinson Disease-compared-Diabetes Mellitus', 'Parkinson Disease-experience-Sleep Wake Disorders', 'Sleep Wake Disorders-experience-Diabetes Mellitus', 'Sleep Wake Disorders-explained-Parkinson Disease', 'Seizures-occur-Neurodegenerative Diseases', 'Heredodegenerative Disorders, Nervous System-cause-Seizures', 'Alzheimer Disease-cause-Seizures', 'Venous Thrombosis-lead-Pulmonary Embolism', 'Hyperuricemia-counteract-Atherosclerosis', 'Cardiomyopathy, Hypertrophic-provide-Heart Failure', 'Ventricular Remodeling-provide-Heart Failure', 'Diabetes Mellitus-diagnose-Myopia', 'Diabetes Mellitus-diagnose-Macular Degeneration', 'Diabetes Mellitus-diagnose-Cataract', 'Myopia-diagnose-Macular Degeneration', 'Myopia-diagnose-Cataract', 'Macular Degeneration-diagnose-Cataract', 'Death-explain-Retroviridae Infections', 'Hypertension-predispose-Kidney Diseases', 'Diarrhea-acquire-Infections', 'Sleep Initiation and Maintenance Disorders-experience-Restless Legs Syndrome', 'Sleep Initiation and Maintenance Disorders-experience-Nocturnal Myoclonus Syndrome', 'Sleepiness-occur-Restless Legs Syndrome', 'Sleepiness-occur-Nocturnal Myoclonus Syndrome', 'Collagen Diseases-understand-Bone Diseases, Metabolic', 'Cerebrovascular Disorders-examined-Stroke', 'Coronary Artery Disease-narrow-Atherosclerosis', 'Coronary Artery Disease-identified-Hypertension', 'Coronary Artery Disease-include-Hyperlipidemias', 'Coronary Artery Disease-identified-Hyperlipidemias', 'Coronary Artery Disease-identified-Diabetes Mellitus', 'Coronary Artery Disease-identified-Obesity', 'Coronary Artery Disease-involve-Myocardial Infarction', 'Coronary Artery Disease-diagnose-Myocardial Infarction', 'Hypercholesterolemia-control-Coronary Artery Disease', 'Long QT Syndrome-linked-Arrhythmias, Cardiac', 'Wounds and Injuries-account-Fractures, Bone', 'Thrombosis-lead-Arterial Occlusive Diseases', 'Neoplasms-account-Microsatellite Instability', 'Retinal Vein Occlusion-associated-Dementia, Vascular', 'Dementia, Vascular-associated-Retinal Vein Occlusion', 'Retinal Vein Occlusion-evaluated-Thrombosis', 'Werner Syndrome-detect-Genetic Diseases, Inborn', 'Nervous System Diseases-related-Wounds and Injuries', 'Hypertension-explain-Death', 'Hyperhomocysteinemia-associated-Renal Insufficiency', 'Renal Insufficiency-associated-Hyperhomocysteinemia', 'Immunologic Deficiency Syndromes-associated-Renal Insufficiency', 'Renal Insufficiency-associated-Immunologic Deficiency Syndromes', 'Pain-associated-Hyperalgesia', 'Hyperalgesia-associated-Pain', 'Osteoporosis-develop-Breast Neoplasms', 'Genetic Diseases, Inborn-associated-Leukemia, Myeloid, Acute', 'Leukemia, Myeloid, Acute-associated-Genetic Diseases, Inborn', 'Leukemia, Myeloid, Acute-characterized-Genetic Diseases, Inborn', 'Obesity, Abdominal-increase-Diabetes Mellitus, Type 2', 'Dermatitis, Atopic-characterized-Pruritus', 'Dermatitis, Atopic-show-Skin Diseases', 'Cerebral Infarction-result-Hereditary Breast and Ovarian Cancer Syndrome', 'Stroke-result-Hereditary Breast and Ovarian Cancer Syndrome', 'Hereditary Breast and Ovarian Cancer Syndrome-related-Brain Diseases', 'Urinary Incontinence, Stress-defined-Dry Eye Syndromes', 'Sleep Initiation and Maintenance Disorders-focus-Sleep Wake Disorders', 'Prostatic Diseases-develop-Prostatic Neoplasms', 'Prostatic Diseases-affect-Prostatic Neoplasms', 'Hyperthyroidism-know-Hypothyroidism', 'Leukoencephalopathies-show-Hypertension', 'Leukoencephalopathies-show-Dementia, Vascular', 'Urinary Incontinence-urge-Gait Disorders, Neurologic', 'Cerebrovascular Disorders-found-Brain Neoplasms', 'Brain Neoplasms-seen-Craniocerebral Trauma', 'Brain Neoplasms-seen-Substance-Related Disorders', 'Pain-related-Migraine Disorders', 'Leukemia-account-Leukemia, Myeloid, Acute', 'Precursor Cell Lymphoblastic Leukemia-Lymphoma-found-Hematologic Diseases', 'Leukemia-treated-Hodgkin Disease', 'Leukemia-treated-Lymphoma, Non-Hodgkin', 'Leukemia-treated-Multiple Myeloma', 'Leukemia-treated-Polycythemia', 'Leukemia-treated-Breast Neoplasms', 'Leukemia-treated-Ovarian Neoplasms', 'Leukemia-treated-Testicular Neoplasms', 'Coinfection-become-Neoplasms', 'Mycosis Fungoides-represent-Lymphoma, T-Cell, Cutaneous', 'Hypertension-known-Stroke', 'Muscle Weakness-include-Hip Fractures', 'Vision Disorders-include-Hip Fractures', 'Hyperthyroidism-include-Hip Fractures', 'Bronchial Diseases-evaluate-Asthma', 'Bradycardia-decrease-Nephrotic Syndrome', 'Carcinoma, Squamous Cell-followed-Adenocarcinoma', 'Atherosclerosis-used-Cerebral Infarction', 'Atherosclerosis-tolerate-Death', 'Fragile X Syndrome-obliterate-Abnormalities, Drug-Induced', 'Atrophy-obliterate-Abnormalities, Drug-Induced', 'Hypertension-assessed-Glycosuria, Renal', 'Diabetes Mellitus-assessed-Hypertension', 'Diabetes Mellitus-assessed-Glycosuria, Renal', 'Glaucoma-assessed-Hypertension', 'Glaucoma-assessed-Glycosuria, Renal', 'Vision Disorders-assessed-Hypertension', 'Vision Disorders-assessed-Glycosuria, Renal', 'Hypertension-show-Coronary Artery Disease', 'Hypertension-show-Cerebrovascular Disorders', 'Hypertension-show-Heart Failure', 'Erythema Nodosum-cover-Erysipelas', 'Erythema Nodosum-resemble-Erysipelas', 'Necrosis-control-Infections', 'Infections-remove-Ulcer', 'Nasal Polyps-associated-Respiratory Tract Infections', 'Respiratory Tract Infections-associated-Nasal Polyps', 'Respiratory Tract Infections-associated-Rhinitis, Allergic', 'Rhinitis, Allergic-associated-Respiratory Tract Infections', 'Cardiovascular Diseases-described-Cerebral Palsy', 'Hyperparathyroidism, Secondary-implicated-Osteoporosis', 'Rupture-mean-Muscle Weakness', 'Ischemia-underlie-Infarction, Anterior Cerebral Artery', 'Ocular Hypertension-diagnosed-Intervertebral Disc Degeneration', 'Glaucoma, Open-Angle-match-Eye Diseases', 'Ocular Hypertension-report-Glaucoma', 'Anophthalmos-include-Glaucoma, Open-Angle', 'Glaucoma-include-Glaucoma, Open-Angle', 'Anophthalmos-include-Ocular Hypertension', 'Glaucoma-include-Ocular Hypertension', 'Renal Insufficiency-caused-Diabetes Mellitus', 'Alzheimer Disease-compare-Stroke', 'Substance-Related Disorders-needed-Dementia', 'Alzheimer Disease-found-Nervous System Diseases', 'Alzheimer Disease-found-Gait Disorders, Neurologic', 'Alzheimer Disease-contribute-Hypotension, Orthostatic', 'Diarrhea-observed-Alzheimer Disease', 'Deglutition Disorders-observed-Alzheimer Disease', 'Vertigo-observed-Alzheimer Disease', 'Alzheimer Disease-observed-Hypotension, Orthostatic', 'Lung Injury-found-Infections', 'Diabetes Mellitus-develop-Infections', 'Delirium-combined-Dementia', 'Hyperthyroidism-found-Hypothyroidism', 'Stroke-demonstrated-Central Nervous System Diseases', 'Embolism-increase-Atherosclerosis', 'Neoplasms-established-Arthritis', 'Rheumatic Diseases-established-Arthritis', 'Edema-include-Neoplasms', 'Arthritis-present-Arthritis, Rheumatoid', "Arthritis-present-Sjogren's Syndrome", 'Sacroiliitis-include-Neoplasms', 'Arthritis-present-Osteoarthropathy, Primary Hypertrophic', 'Arthritis-present-Dermatomyositis', 'Arthritis-present-Polymyalgia Rheumatica', 'Arthritis-present-Lambert-Eaton Myasthenic Syndrome', 'Arthritis-present-Fasciitis', 'Scleroderma, Systemic-include-Neoplasms', 'Arthritis-present-Erythema Nodosum', 'Arthritis-present-Raynaud Disease', 'Arthritis-present-Vasculitis, Leukocytoclastic, Cutaneous', 'Osteomalacia-include-Neoplasms', 'Hyperostosis, Diffuse Idiopathic Skeletal-include-Neoplasms', 'Antiphospholipid Syndrome-include-Neoplasms', 'Cryoglobulinemia-include-Neoplasms', 'Rheumatic Diseases-include-Edema', 'Rheumatic Diseases-extended-Edema', 'Rheumatic Diseases-include-Sacroiliitis', 'Rheumatic Diseases-extended-Sacroiliitis', 'Rheumatic Diseases-extended-Arthritis, Juvenile', 'Rheumatic Diseases-include-Dermatomyositis', 'Rheumatic Diseases-extended-Dermatomyositis', 'Rheumatic Diseases-include-Scleroderma, Systemic', 'Rheumatic Diseases-extended-Scleroderma, Systemic', 'Rheumatic Diseases-extended-Sweet Syndrome', 'Rheumatic Diseases-include-Osteomalacia', 'Rheumatic Diseases-extended-Osteomalacia', 'Rheumatic Diseases-include-Hyperostosis, Diffuse Idiopathic Skeletal', 'Rheumatic Diseases-extended-Hyperostosis, Diffuse Idiopathic Skeletal', 'Rheumatic Diseases-include-Antiphospholipid Syndrome', 'Rheumatic Diseases-extended-Antiphospholipid Syndrome', 'Rheumatic Diseases-include-Cryoglobulinemia', 'Rheumatic Diseases-extended-Cryoglobulinemia', 'Diabetes Mellitus-increase-Cardiac Complexes, Premature', 'Anemia-include-Contracture', 'Thrombocytopenia-include-Contracture', 'Pulmonary Fibrosis-include-Contracture', 'Pericarditis-include-Contracture', 'Arbovirus Infections-eliminate-Neoplasms', 'Cardiovascular Diseases-predict-Glucose Metabolism Disorders', 'Goiter, Nodular-found-Thyroid Neoplasms', 'Calcinosis-affected-Goiter, Nodular', 'Peripheral Arterial Disease-increase-Fatigue', 'Neurodegenerative Diseases-manifested-Chorea', 'Infections-characterized-Necrosis', 'Infections-characterized-Thrombosis', 'Infections-characterized-Drug-Related Side Effects and Adverse Reactions', 'Infections-extend-Fistula', 'Infections-extend-Smear Layer', 'Infections-extend-Fasciitis, Necrotizing', 'Fistula-extend-Fasciitis, Necrotizing', 'Smear Layer-extend-Fasciitis, Necrotizing', 'Heart Failure-revealed-Heart Diseases', 'Multiple Myeloma-contribute-Death', 'Weight Loss-associated-Anemia', 'Anemia-associated-Weight Loss', 'Weight Loss-associated-Hypertension', 'Hypertension-associated-Weight Loss', 'Delirium-reported-Dementia', 'Drug-Related Side Effects and Adverse Reactions-reported-Dementia', 'Drug-Related Side Effects and Adverse Reactions-occur-Dementia', 'Drug-Related Side Effects and Adverse Reactions-present-Dementia', 'Osteoporosis-incur-Bone Neoplasms', 'Hereditary Angioedema Type III-lead-Bone Neoplasms', 'Hypertension-identified-Cerebral Hemorrhage', 'Meniere Disease-caused-Hearing Loss', 'Dementia-mentioned-Death', 'Alzheimer Disease-recorded-Death', 'Dementia, Vascular-recorded-Death', 'Alzheimer Disease-use-Death', 'Dementia, Vascular-use-Death', 'Thinness-associated-Death', 'Death-associated-Thinness', 'Death-reduced-Weight Loss', 'Psychomotor Disorders-drive-Rhinitis, Allergic, Seasonal', 'Asthma-aggravate-Gastroesophageal Reflux', 'Gastroesophageal Reflux-treated-Headache Disorders, Secondary', 'Asthma-treated-Gastroesophageal Reflux', 'Hip Fractures-seen-Hematoma', 'Chest Pain-define-Coronary Artery Disease', 'Brain Diseases-form-Communicable Diseases', 'Hypertension-introduce-Basal Ganglia Cerebrovascular Disease', 'Arthritis, Rheumatoid-differ-Abortion, Threatened', 'Aneurysm-contribute-Death', 'Osteoporosis-include-Kyphosis', 'Infections-occur-Bronchopulmonary Dysplasia', 'Dementia, Vascular-use-Alzheimer Disease', 'Appendicitis-complicated-Soft Tissue Infections', 'Soft Tissue Infections-characterized-Inflammation', 'Soft Tissue Infections-characterized-Necrosis', 'Soft Tissue Infections-comprise-Necrosis', 'Soft Tissue Infections-comprise-Infections', 'Soft Tissue Infections-characterized-Infections', 'Inflammation-comprise-Necrosis', 'Inflammation-comprise-Infections', 'Necrosis-comprise-Infections', 'Gallstones-develop-Neoplasms', 'Death-caused-Multiple Organ Failure', 'Cachexia-associated-Pressure Ulcer', 'Pressure Ulcer-associated-Cachexia', 'Cachexia-associated-Death', 'Death-associated-Cachexia', 'Mouth Breathing-diminish-Chronic Disease', 'Dehydration-diminish-Chronic Disease', 'Autoimmune Diseases-diminish-Chronic Disease', 'Xerostomia-lead-Dysgeusia', 'Xerostomia-lead-Glossalgia', 'Xerostomia-lead-Sialadenitis', 'Xerostomia-lead-Halitosis', 'Neuralgia-encourage-Pain', 'Hypertension-relate-Cardiomyopathy, Hypertrophic', 'Diabetes Mellitus, Type 2-include-Seizures', 'Diabetes Mellitus, Type 2-improve-Seizures', 'Alzheimer Disease-play-Brain Injuries, Traumatic', 'Alzheimer Disease-followed-Dementia', 'Alzheimer Disease-associated-Fragile X Syndrome', 'Fragile X Syndrome-associated-Alzheimer Disease', 'Fragile X Syndrome-demonstrate-Alzheimer Disease', 'Death-occur-Mucositis', 'Death-occur-Fever', 'Death-occur-Kidney Diseases', 'Glaucoma, Open-Angle-result-Vision Disorders', 'Neurodegenerative Diseases-expressed-Alzheimer Disease', 'Tetany-take-Death', 'Lens Diseases-increased-Diabetes Mellitus', 'Chest Pain-indicate-Coronary Artery Disease', 'Dyspnea-indicate-Coronary Artery Disease', 'Tremor-regarded-Nervous System Diseases', 'Tremor-regarded-Stroke', 'Tremor-regarded-Alzheimer Disease', 'Tremor-regarded-Migraine Disorders', 'Obesity-categorized-Diabetes Mellitus', 'Anorexia-range-Gastrointestinal Diseases', 'Diabetes Mellitus-found-Angina Pectoris', 'Diabetes Mellitus-found-Hypertension', 'Ventricular Dysfunction, Left-prove-Death', 'Intracranial Embolism-associated-Embolism', 'Embolism-associated-Intracranial Embolism', 'Intracranial Embolism-associated-Death', 'Death-associated-Intracranial Embolism', 'Embolism-condition-Death', 'Embolism-determine-Death', 'Sleep Initiation and Maintenance Disorders-associated-Signs and Symptoms, Respiratory', 'Signs and Symptoms, Respiratory-associated-Sleep Initiation and Maintenance Disorders', 'Sleep Initiation and Maintenance Disorders-explain-Heart Diseases', 'Sleep Initiation and Maintenance Disorders-explain-Stroke', 'Sleep Initiation and Maintenance Disorders-explain-Diabetes Mellitus', 'Cataract-consider-Muscular Dystrophies', 'Intellectual Disability-consider-Muscular Dystrophies', 'Walker-Warburg Syndrome-show-Intellectual Disability', 'Walker-Warburg Syndrome-show-Brain Diseases', 'Parkinson Disease-produce-Stroke', 'Parkinson Disease-maintain-Stroke', 'Drug Overdose-induce-Ischemia', 'Dyslipidemias-prevent-Hypertension', 'Fractures, Bone-associated-Asthma', 'Asthma-associated-Fractures, Bone', 'Cerebrovascular Disorders-associated-Hypotension', 'Hypotension-associated-Cerebrovascular Disorders', 'Anorexia-occur-Weight Loss', 'Blood Platelet Disorders-promote-Cardiovascular Diseases', 'Blood Platelet Disorders-promote-Diabetes Mellitus', 'Diabetes Mellitus-remove-Cardiovascular Diseases', 'Cardiovascular Diseases-remove-Diabetes Mellitus', 'Cardiovascular Diseases-exceed-Parasitic Diseases', 'Dysplastic Nevus Syndrome-provide-Retinal Degeneration', 'Brain Neoplasms-occur-Genetic Diseases, Inborn', 'Osteoporosis-recognised-Fractures, Bone', 'Bone Neoplasms-include-Wounds and Injuries', 'Osteoporosis-affect-Femoral Fractures', 'Infections-require-Alzheimer Disease', 'Alzheimer Disease-diagnosed-Dementia, Vascular', 'Thyroid Diseases-accelerate-Hypothyroidism', 'Gastritis-associated-Gastroesophageal Reflux', 'Gastroesophageal Reflux-associated-Gastritis', 'Stomach Ulcer-associated-Gastroesophageal Reflux', 'Gastroesophageal Reflux-associated-Stomach Ulcer', 'Meningitis, Bacterial-related-Esophageal Neoplasms', 'Shy-Drager Syndrome-become-Pain', 'Myocardial Infarction-tend-Coronary Artery Disease', 'Coronary Artery Disease-decrease-Death', 'Intellectual Disability-prevent-Atrophy', 'Basal Ganglia Diseases-show-Tremor', 'Basal Ganglia Diseases-show-Akathisia, Drug-Induced', 'Basal Ganglia Diseases-diagnosed-Dyskinesia, Drug-Induced', 'Parkinson Disease, Secondary-induced-Dyskinesia, Drug-Induced', 'Dyskinesia, Drug-Induced-show-Parkinson Disease, Secondary', 'Dyskinesia, Drug-Induced-show-Akathisia, Drug-Induced', 'Basal Ganglia Diseases-limited-Dyskinesia, Drug-Induced', 'Alzheimer Disease-enhance-Neurodegenerative Diseases', 'Hypertension-increasing-Stroke', 'Hypertension-precede-Heart Failure', 'Kidney Failure, Chronic-attributed-Diabetes Mellitus', 'Kidney Failure, Chronic-attributed-Hypertension', 'Malnutrition-cause-Osteoporosis', 'Ulcer-provide-Wounds and Injuries', 'Psychoses, Substance-Induced-become-Parkinson Disease', 'Psychoses, Substance-Induced-become-Parkinsonian Disorders', 'Psychoses, Substance-Induced-associated-Parkinson Disease', 'Parkinson Disease-associated-Psychoses, Substance-Induced', 'Psychoses, Substance-Induced-associated-Parkinson Disease, Secondary', 'Parkinson Disease, Secondary-associated-Psychoses, Substance-Induced', 'Psychomotor Agitation-associated-Psychoses, Substance-Induced', 'Psychoses, Substance-Induced-associated-Psychomotor Agitation', 'Hemostatic Disorders-detected-Colitis, Ischemic', 'Neutropenia-caused-Infections', 'Myxedema-prevent-Death', 'Hypothyroidism-prevent-Death', 'Focal Infection-found-Arthritis, Infectious', 'Bacteremia-account-Sepsis', 'Focal Infection-found-Infections', 'Focal Infection-found-Meningitis, Bacterial', 'Focal Infection-found-Pneumonia', 'Venous Thromboembolism-continue-Death', 'Alzheimer Disease-contribute-Dementia, Vascular', 'Death-identify-Shock, Septic', 'Sleep Wake Disorders-associated-Heart Diseases', 'Heart Diseases-associated-Sleep Wake Disorders', 'Sleep Wake Disorders-associated-Pulmonary Disease, Chronic Obstructive', 'Pulmonary Disease, Chronic Obstructive-associated-Sleep Wake Disorders', 'Apnea-associated-Pneumonia', 'Pneumonia-associated-Apnea', 'Sleep Wake Disorders-contribute-Sleep Initiation and Maintenance Disorders', 'Apnea-lead-Sleep Wake Disorders', 'Sleep Wake Disorders-noted-Diurnal Enuresis', 'Hypertension-suffer-Heart Failure', 'Hypertension-interfere-Glucose Metabolism Disorders', 'Periodontal Diseases-increase-Tooth Loss', 'Rothmund-Thomson Syndrome-characterized-Cataract', 'Rothmund-Thomson Syndrome-known-Genetic Diseases, Inborn', 'Rothmund-Thomson Syndrome-known-Neoplasms', 'Neoplasms-enlarge-Adenoma', 'Heart Failure-document-Heart Diseases', 'Death-compared-Cataract', 'Pruritus-range-Nasal Obstruction', 'Abnormalities, Drug-Induced-exposed-Rhinitis, Allergic', 'Abnormalities, Drug-Induced-treat-Rhinitis, Allergic', 'Weight Loss-decrease-Death', 'Adenocarcinoma-distinguish-Adenoma', 'Neoplasms-differentiated-Mouth Diseases', 'Bronchitis-complicated-Airway Obstruction', 'Diabetes Mellitus-confirmed-Sensation Disorders', 'Aging, Premature-associated-Fibrosis', 'Fibrosis-associated-Aging, Premature', 'Parkinson Disease, Secondary-reported-Urticaria', 'Parkinson Disease, Secondary-reported-Akathisia, Drug-Induced', 'Parkinson Disease, Secondary-reported-Vision Disorders', 'Hallucinations-reported-Urticaria', 'Hallucinations-reported-Akathisia, Drug-Induced', 'Hallucinations-reported-Vision Disorders', 'Bradycardia-reported-Urticaria', 'Bradycardia-reported-Akathisia, Drug-Induced', 'Bradycardia-reported-Vision Disorders', 'Fatigue-seen-Dyskinesia, Drug-Induced', 'Fatigue-seen-Akathisia, Drug-Induced', 'Death-result-Multiple Organ Failure', 'Death-result-Respiratory Insufficiency', 'Death-involved-Respiratory Insufficiency', 'Multiple Organ Failure-involved-Respiratory Insufficiency', 'Death-include-Gastrointestinal Hemorrhage', 'Arthritis, Infectious-develop-Osteoarthritis', 'Heart Failure-include-Cardiomyopathy, Dilated', 'Heart Failure-revisited-Hypertension', 'Coronary Artery Disease-revisited-Hypertension', 'Cardiomyopathy, Dilated-revisited-Hypertension', 'Hypertrophy, Left Ventricular-show-Heart Diseases', 'Hypertrophy, Left Ventricular-show-Heart Failure, Diastolic', 'Hypertension-show-Heart Failure, Diastolic', 'Waldenstrom Macroglobulinemia-demonstrate-Lymphoma', 'Skin Diseases-demonstrate-Lymphoma', 'Waldenstrom Macroglobulinemia-involve-Skin Diseases', 'Waldenstrom Macroglobulinemia-develop-Skin Diseases', 'Tricuspid Valve Stenosis-include-Pulmonary Atresia', 'Tricuspid Valve Stenosis-include-Ebstein Anomaly', 'Hyperplasia-indicate-Sotos Syndrome', 'Alzheimer Disease-compared-Atrophy', 'Neoplasms-said-Cytomegalovirus Infections', 'Cytomegalovirus Infections-occur-Hematologic Neoplasms', 'Infections-occur-Hematologic Neoplasms', 'Parkinson Disease-hampered-Infections', 'Neurologic Manifestations-implicate-Alzheimer Disease', 'Immunologic Deficiency Syndromes-contribute-Carcinogenesis', 'Diabetes Mellitus-study-Obesity', 'Diabetes Mellitus-study-Hypertension', 'Shock-induced-Fever', 'Neoplasms-remove-Neoplasm Metastasis', 'Venous Thrombosis-lead-Urinary Bladder Diseases', 'Edema-mimic-Venous Thrombosis', 'Carcinogenesis-translate-Neoplasms', 'Lung Diseases-contribute-Death', 'Lung Diseases-suggested-Hermanski-Pudlak Syndrome', 'Death-suggested-Hermanski-Pudlak Syndrome', 'Bone Diseases, Metabolic-occur-Kidney Failure, Chronic', 'Kidney Failure, Chronic-occur-Hypogonadism', 'Stroke-play-Hypertension', 'Headache-play-Hypertension', 'Kidney Failure, Chronic-play-Hypertension', 'Heart Failure-play-Hypertension', 'Fibrosis-progress-Blindness', 'Thyroid Neoplasms-occur-Werner Syndrome', 'Multiple Myeloma-experience-Unconsciousness', 'Multiple Myeloma-experience-Seizures', 'Cardiovascular Diseases-reflect-Heart Failure', 'Hypertrophy-discussed-Heart Failure', 'Cardiomyopathies-discussed-Heart Failure', 'Atrial Fibrillation-cause-Thromboembolism', 'Heart Valve Diseases-increase-Death', 'Heart Valve Diseases-related-Coronary Artery Disease', 'Heart Valve Diseases-related-Ischemia', 'Lung Neoplasms-follow-Neoplasms', 'Colorectal Neoplasms-follow-Death', 'Lung Neoplasms-follow-Death', 'Death-promoted-Neoplasms', 'Hypotension-avoid-Atherosclerosis', 'Tachycardia, Ventricular-thought-Death, Sudden', 'Hypothermia-feel-Heart Arrest', 'Hypothermia-feel-Death', 'Weight Loss-increase-Neoplasms', 'Ulcer-found-Brain Infarction', 'Hyperparathyroidism, Secondary-associated-Hip Fractures', 'Hip Fractures-associated-Hyperparathyroidism, Secondary', 'Hyperparathyroidism, Secondary-related-Kidney Diseases', 'Diabetes Mellitus, Type 1-coded-Diabetes Mellitus', 'Diabetes Mellitus-experience-Drug-Related Side Effects and Adverse Reactions', 'Drug-Related Side Effects and Adverse Reactions-develop-Diabetes Mellitus', 'Drug-Related Side Effects and Adverse Reactions-remain-Diabetes Mellitus', 'Gastrointestinal Diseases-render-Cell Transformation, Viral', 'Pancreatitis, Acute Necrotizing-suffer-Death', 'Bilateral Vestibulopathy-caused-Hyperparathyroidism', 'Diplopia-caused-Hyperparathyroidism', 'Coronary Artery Disease-observed-Death', 'Aneurysm-develop-Myocardial Infarction', 'Aneurysm-develop-Angina Pectoris', 'Aneurysm-develop-Death', 'Death-observed-Multiple Myeloma', 'Hepatitis C-evaluated-Lymphoproliferative Disorders', 'Death-target-Neoplasms', 'Hypoxia-tend-Asthma', 'Alzheimer Disease-used-Mitochondrial Diseases', 'Alzheimer Disease-induce-Mitochondrial Diseases', 'Hypotension-increase-Diabetes Mellitus', 'Osteoporosis-lead-Oculocerebrorenal Syndrome', 'Neoplasms-examined-Infections', 'Alzheimer Disease-appear-Dementia, Vascular', 'Death-decrease-Dementia, Vascular', 'Hip Fractures-report-Parkinson Disease', 'Hip Fractures-report-Stroke', 'Myocardial Infarction-associated-Intracranial Hemorrhages', 'Intracranial Hemorrhages-associated-Myocardial Infarction', 'Herpes Zoster Ophthalmicus-develop-Encephalitis', 'Neoplasms-present-Back Pain', 'Vision Disorders-found-Hypertension', 'Myelodysplastic Syndromes-cause-Bone Marrow Diseases', 'Hematologic Neoplasms-cause-Bone Marrow Diseases', 'Myelodysplastic Syndromes-share-Leukemia, Myeloid, Acute', 'Aortic Aneurysm, Abdominal-suppress-Aneurysm', 'Aortic Aneurysm, Abdominal-exist-Aneurysm', 'Inflammation-play-Aneurysm', 'Hematoma, Epidural, Spinal-result-Neoplasms', 'Small Cell Lung Carcinoma-produce-Hematoma', 'Neoplasm Metastasis-produce-Hematoma', 'Biliary Dyskinesia-recur-Cholangitis', 'Cholangitis-see-Bile Duct Neoplasms', 'Airway Obstruction-recur-Cholangitis', 'Jaundice, Obstructive-seem-Pregnancy Complications, Infectious', 'Blood Coagulation Disorders-alter-Aneurysm', 'Neuromuscular Diseases-improve-Hyperkinesis', 'Iliotibial Band Syndrome-categorize-Musculoskeletal Diseases', 'Inflammation-shown-Coronary Artery Disease', 'Inflammation-cause-Coronary Occlusion', 'Infections-cause-Coronary Occlusion', 'Cardiovascular Diseases-connected-Dementia, Vascular', 'Cardiovascular Diseases-connected-Coronary Artery Disease', 'Death-related-Splenic Diseases', 'Hyperthyroidism-underlie-Chronic Disease', 'Hyperthyroidism-underlie-Cardiovascular Diseases', 'Papilledema-reveal-Adenocarcinoma', 'Adenocarcinoma-show-Pancreatic Neoplasms', 'Fallopian Tube Diseases-associated-Neoplasms', 'Neoplasms-associated-Fallopian Tube Diseases', 'Metabolism, Inborn Errors-increased-Aneurysm', 'Homocystinuria-increased-Aneurysm', 'Bone Neoplasms-reduce-Hip Fractures', 'Cardiomyopathies-disclose-Fragile X Syndrome', 'Death-reported-Cardiomyopathies', 'Death-reported-Heart Block', 'Death-reported-Neurodegenerative Diseases', 'Death-derived-Neoplasms', 'Diabetes Mellitus, Type 2-remain-Death', 'Glaucoma-related-Cataract', 'Osteoporotic Fractures-suffer-Oculocerebrorenal Syndrome', 'Osteoporotic Fractures-present-Fractures, Bone', 'Heart Failure-complicate-Atrial Fibrillation', 'Thyrotoxicosis-aggravate-Heart Diseases', 'Thyrotoxicosis-lead-Atrial Fibrillation', 'Thyrotoxicosis-aggravate-Heart Failure', 'Thyrotoxicosis-lead-Angina Pectoris', 'Heart Diseases-lead-Angina Pectoris', 'Cardiovascular Abnormalities-persist-Atrial Fibrillation', 'Gastrointestinal Diseases-exclude-Craniocerebral Trauma', 'Gastrointestinal Diseases-exclude-Dementia', 'Musculoskeletal Diseases-exclude-Craniocerebral Trauma', 'Musculoskeletal Diseases-exclude-Dementia', 'Diabetes Mellitus-precede-Cataract', 'Headache-develop-Arthralgia', 'Wounds, Nonpenetrating-compare-Wounds and Injuries', 'Mitochondrial Diseases-block-Heart Block', 'Cardiomyopathy, Dilated-block-Heart Block', 'Tetany-remain-Death', 'Muscular Dystrophy, Facioscapulohumeral-accelerate-Pulmonary Atresia', 'Heart Failure-demonstrate-Cachexia', 'Aneurysm-contribute-Kidney Failure, Chronic', 'Chronic Disease-consider-Dystonia', 'Neutropenia-hospitalised-Fever', 'Thrombocytopenia-hospitalised-Fever', 'Endocarditis-result-Heart Failure', 'Endocarditis-present-Fever', 'Death-related-Staphylococcal Infections', 'Death-related-Endocarditis', 'Death-related-Embolism', 'Death-related-Neurologic Manifestations', 'Endocarditis-related-Staphylococcal Infections', 'Endocarditis-related-Heart Failure', 'Endocarditis-related-Embolism', 'Endocarditis-related-Neurologic Manifestations', 'Wounds and Injuries-influence-Memory Disorders', 'Chest Pain-reflect-Angina Pectoris', 'Cardiovascular Diseases-ascribed-Atherosclerosis', 'Cardiovascular Diseases-ascribed-Arteriosclerosis', 'Hypertension-ascribed-Atherosclerosis', 'Hypertension-ascribed-Arteriosclerosis', 'Werner Syndrome-known-Aging, Premature', 'Melioidosis-considered-Communicable Diseases', 'Paralysis-emerge-Acquired Immunodeficiency Syndrome', 'Neoplasms-combined-Skin Neoplasms', 'Death-seem-Ventricular Fibrillation', 'Ventricular Fibrillation-associated-Heart Failure', 'Heart Failure-associated-Ventricular Fibrillation', 'Alzheimer Disease-decrease-Cerebrovascular Disorders', 'Meniere Disease-characterized-Vertigo', 'Meniere Disease-characterized-Tinnitus', 'Stroke-accounted-Death', 'Multiple Organ Failure-accounted-Death', 'Acquired Immunodeficiency Syndrome-show-Atrophy', 'Malaria, Falciparum-show-Atrophy', 'Death-suffer-Myocardial Infarction', 'Cardiac Output, Low-suffer-Myocardial Infarction', 'Respiration Disorders-affect-Death', 'Hypertension-treated-Myasthenia Gravis', 'Hypertension-treated-Myasthenic Syndromes, Congenital', 'Vascular Calcification-signify-Cardiovascular Diseases', 'Ovarian Diseases-fit-Seizures', 'Xerostomia-report-Disorders of Excessive Somnolence', 'Arrhythmias, Cardiac-provide-Bradycardia', 'Bradycardia-terminate-Tachycardia, Ventricular', 'Multiple Myeloma-establish-Kidney Diseases', 'Kidney Diseases-assessed-Multiple Myeloma', 'Kidney Diseases-brought-Multiple Myeloma', 'Multiple Myeloma-assessed-Kidney Diseases', 'Acute Kidney Injury-considered-Kidney Failure, Chronic', 'Hyperthyroidism-occur-Goiter', 'Lymphoma-included-Death', 'Lymphoma-contribute-Death', 'Drug-Related Side Effects and Adverse Reactions-included-Death', 'Pain-become-Kyphosis', 'Pain-become-Scoliosis', 'Pneumonia-classified-Infections', 'Pneumonia-include-Diabetes Mellitus', 'Pneumonia-include-Kidney Diseases', 'Pneumonia-include-Pulmonary Disease, Chronic Obstructive', 'Meningeal Neoplasms-undergo-Death', 'Weight Loss-include-Malnutrition', 'Heart Failure-impair-Ventricular Dysfunction, Left', 'Ventricular Dysfunction, Left-associated-Renal Insufficiency', 'Renal Insufficiency-associated-Ventricular Dysfunction, Left', 'Gonorrhea-present-Meningitis', 'Stomach Neoplasms-develop-Neoplasms', 'Arteriovenous Malformations-associated-Hypertension', 'Hypertension-associated-Arteriovenous Malformations', 'Hypertension-exhibit-Hyperkinesis', 'Hyperkinesis-reviewed-Neuralgia', 'Hyperkinesis-reviewed-Hemifacial Spasm', 'Dementia, Vascular-accelerated-Hypertension', 'Hypertension-accelerated-Hyperkinesis', 'Cardiovascular Diseases-increase-Fat Necrosis', 'Heart Failure-result-Hypotension', 'Cataract-include-Diabetes Mellitus', 'Renal Insufficiency-include-Diabetes Mellitus', 'Heat Stroke-affect-Obesity', 'Heat Stroke-affect-Thyroid Diseases', 'Retinopathy of Prematurity-recognized-Drug-Related Side Effects and Adverse Reactions', 'Retinopathy of Prematurity-appreciated-Bronchopulmonary Dysplasia', 'Retinopathy of Prematurity-appreciated-Respiratory Distress Syndrome', 'Drug-Related Side Effects and Adverse Reactions-appreciated-Bronchopulmonary Dysplasia', 'Death-compare-Hemorrhage', 'Memory Disorders-investigated-Alzheimer Disease', 'Alzheimer Disease-report-Memory Disorders', 'Epstein-Barr Virus Infections-play-Hodgkin Disease', 'Colorectal Neoplasms-decrease-Neoplasms', 'Hip Fractures-defined-Fractures, Bone', 'Kidney Diseases-become-Kidney Failure, Chronic', 'Neoplasms-help-Stroke', 'Diabetic Neuropathies-carried-Diabetes Mellitus', 'Diabetes Mellitus-excluded-Nervous System Diseases', 'Diabetes Mellitus-prevent-Nervous System Diseases', 'Polyneuropathies-carried-Diabetes Mellitus', 'Diabetic Foot-prevent-Diabetic Neuropathies', 'Alzheimer Disease-contain-Plaque, Amyloid', 'Plaque, Amyloid-induce-Keratitis, Dendritic', 'Immunologic Deficiency Syndromes-used-Coronaviridae Infections', 'Anastomotic Leak-occur-Death', 'Weight Loss-attributed-Steatorrhea', 'Weight Loss-attributed-Taste Disorders', 'Weight Loss-attributed-Inflammatory Bowel Diseases', 'Weight Loss-attributed-Blind Loop Syndrome', 'Blind Loop Syndrome-play-Steatorrhea', 'Muscle Weakness-consider-Myasthenia Gravis', 'Chiari-Frommel Syndrome-play-Lupus Erythematosus, Systemic', 'Chiari-Frommel Syndrome-play-Thyroiditis, Autoimmune', 'Chiari-Frommel Syndrome-play-Autoimmune Diseases', 'Heart Diseases-show-Death', 'Heart Diseases-caused-Stroke', 'Heart Diseases-show-Neoplasms', 'Hip Fractures-fall-Arthritis', 'Hip Fractures-fall-Stroke', 'Memory Disorders-prevented-Alzheimer Disease', 'Cardiomegaly-evaluate-Chest Pain', 'Diabetes Mellitus-associated-Hypercholesterolemia', 'Hypercholesterolemia-associated-Diabetes Mellitus', 'Cardiovascular Diseases-underlie-Blood Platelet Disorders', 'Kidney Failure, Chronic-include-Kidney Diseases', 'Diabetes Mellitus-suffer-Raynaud Disease', 'Hyperthyroidism-develop-Thyrotoxicosis', 'Pain-include-Fractures, Stress', 'Pain-bear-Fractures, Stress', 'Hyperthyroidism-associated-Bone Neoplasms', 'Bone Neoplasms-associated-Hyperthyroidism', 'Diabetes Mellitus, Type 1-report-Bone Diseases, Metabolic', 'Thyrotoxicosis-develop-Bone Neoplasms', 'Cushing Syndrome-considered-Osteoporosis', 'Bone Neoplasms-consist-Hyperparathyroidism, Secondary', 'Bone Diseases, Metabolic-consist-Osteomalacia', 'Bone Diseases, Metabolic-consist-Hyperparathyroidism, Secondary', 'Osteomalacia-consist-Hyperparathyroidism, Secondary', 'Osteoporotic Fractures-strike-Cardiovascular Diseases', 'Fractures, Bone-strike-Cardiovascular Diseases', 'Osteoporosis-seem-Hip Fractures', 'Hip Fractures-equal-Death', 'Fractures, Bone-affect-Cardiac Output, Low', 'Hip Fractures-shift-Fractures, Bone', 'Babesiosis-reduce-Ehrlichiosis', 'Alzheimer Disease-reduce-Dementia', 'Alzheimer Disease-occur-Memory Disorders', 'Breast Neoplasms-associated-Hepatitis', 'Hepatitis-associated-Breast Neoplasms', 'Diarrhea-cause-Mucositis', 'Rhinitis, Vasomotor-cause-Osteoporosis', 'Rhinitis, Vasomotor-cause-Heart Diseases', 'Vision Disorders-diagnosed-Optic Neuropathy, Ischemic', 'Death-prevent-Alcoholism', 'Death-tend-Genetic Diseases, Inborn', 'Death-overlook-Genetic Diseases, Inborn', 'Liver Failure-result-Death', 'Arrhythmias, Cardiac-result-Liver Failure', 'Heart Failure-result-Liver Failure', 'Neoplasms-result-Liver Failure', 'Death-result-Arrhythmias, Cardiac', 'Death-result-Liver Failure', 'Cardiomyopathies-determine-Hypertension', 'Cardiomyopathy, Hypertrophic-determine-Hypertension', 'Cardiovascular Diseases-highlight-Hypertension', 'Hypertension-result-Hypertrophy, Left Ventricular', 'Renal Artery Obstruction-singled-Hypertension', 'Pheochromocytoma-singled-Hypertension', 'Hypertrophy, Left Ventricular-found-Hypertension', 'Coronary Stenosis-associated-Hypertrophy, Left Ventricular', 'Hypertrophy, Left Ventricular-associated-Coronary Stenosis', 'Hypertrophy, Left Ventricular-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-Hypertrophy, Left Ventricular', 'Hypertrophy, Left Ventricular-demonstrated-Ventricular Fibrillation', 'Hypertrophy, Left Ventricular-improve-Ventricular Fibrillation', 'Hypertrophy, Left Ventricular-demonstrated-Arrhythmias, Cardiac', 'Hypertrophy, Left Ventricular-diminish-Arrhythmias, Cardiac', 'Ventricular Fibrillation-diminish-Arrhythmias, Cardiac', 'Immunologic Deficiency Syndromes-induce-Cerebrovascular Disorders', 'Drug-Related Side Effects and Adverse Reactions-include-Anorexia', 'Drug-Related Side Effects and Adverse Reactions-include-Neurotoxicity Syndromes', 'Neoplasms-resemble-Melanoma', 'Pain-defined-Exanthema', 'Sleep Wake Disorders-include-Pain', 'Anorexia-include-Pain', 'Immunologic Deficiency Syndromes-exacerbate-Dementia', 'Hypothyroidism-termed-Hyperthyroidism', 'Hyperlipidemias-include-Hypothyroidism', 'Retinal Dystrophies-lead-Kearns-Sayre Syndrome', 'Retinal Dystrophies-lead-Blindness', 'Kearns-Sayre Syndrome-lead-Blindness', 'Chorea-excluded-Huntington Disease', 'Basal Ganglia Diseases-predispose-Delirium', 'Delirium-predispose-Hypotension', 'HIV Infections-define-Acquired Immunodeficiency Syndrome', 'Opportunistic Infections-define-Acquired Immunodeficiency Syndrome', 'HIV Infections-offset-Death', 'Acquired Immunodeficiency Syndrome-infected-HIV Infections', 'Death-infected-HIV Infections', 'Hemorrhoids-contribute-Constipation', 'Respiratory Tract Diseases-result-Otitis', 'Parkinson Disease-reveal-Constriction, Pathologic', 'Atrophy-indicate-Alzheimer Disease', 'Dementia-developed-Alzheimer Disease', 'Metabolic Diseases-reflect-Alzheimer Disease', 'Dementia-assess-Stroke', 'Crohn Disease-observed-Diverticulitis', 'Crohn Disease-observed-Neoplasms', 'Kyphosis-seen-Edema', 'Dementia-taken-Stroke', 'Hemolytic-Uremic Syndrome-affected-Hypotension', 'Craniocerebral Trauma-represent-Death', 'Hypertension-ameliorated-Obesity', 'Cardiovascular Diseases-ameliorated-Obesity', 'Sarcopenia-contribute-Stroke', 'Neutropenia-prime-Blast Injuries', 'Death-prime-Blast Injuries', 'Diabetes Mellitus, Type 1-include-Diabetes Mellitus', 'Pneumonia-went-Coma', 'Stroke-reduced-Hypertension', 'Stroke-reduced-Heart Diseases', 'Stroke-reduced-Arrhythmias, Cardiac', 'Stroke-reduced-Ischemia', 'Stroke-reduced-Carotid Stenosis', 'Ichthyosis, X-Linked-account-Alzheimer Disease', 'Leukoaraiosis-include-Hypertension', 'Leukoaraiosis-include-Stroke', 'Drug-Related Side Effects and Adverse Reactions-compare-Neoplasms', 'Colorectal Neoplasms-conducted-Neoplasms', 'Genetic Diseases, Inborn-occur-CADASIL', 'Genetic Diseases, Inborn-occur-Infarction', 'Genetic Diseases, Inborn-occur-Leukoencephalopathies', 'Genetic Diseases, Inborn-occur-Hypertension', 'Diarrhea-observed-Stomatitis', 'Diarrhea-observed-Hand-Foot Syndrome', 'Diarrhea-affect-Drug-Related Side Effects and Adverse Reactions', 'Stomatitis-affect-Drug-Related Side Effects and Adverse Reactions', 'Hand-Foot Syndrome-affect-Drug-Related Side Effects and Adverse Reactions', 'Anemia, Hemolytic-characterized-Acute Kidney Injury', 'Leukoaraiosis-develop-Hypertension', 'Drug-Related Side Effects and Adverse Reactions-suffer-Diarrhea', 'Diarrhea-suffer-Hand-Foot Syndrome', 'Diabetes Mellitus, Type 2-develop-Diabetes Mellitus', 'Diabetes Mellitus-followed-Alcoholism', 'Diabetes Mellitus-followed-Liver Diseases, Alcoholic', 'Polyneuropathies-followed-Liver Diseases, Alcoholic', 'Polyneuropathies-followed-Neoplasms', 'Aortic Valve Stenosis-treated-Airway Obstruction', 'Aortic Diseases-diagnosed-Angina Pectoris', 'Aortic Diseases-diagnosed-Heart Failure', 'Aortic Diseases-diagnosed-Syncope', 'Language Disorders-correspond-Alzheimer Disease', 'Death-predicted-Pulmonary Disease, Chronic Obstructive', 'Death-predicted-Alzheimer Disease', 'Death-predicted-Dementia, Vascular', 'Death-predicted-Skin Neoplasms', 'Death-predicted-Cerebrovascular Disorders', 'Alzheimer Disease-predict-Death', 'Death-predicted-Hypertension', 'Death-predicted-Myocardial Infarction', 'Death, Sudden, Cardiac-increase-Cardiovascular Diseases', 'Delirium-include-Acute Disease', 'Infections-linked-Pneumonia', 'Tuberculosis-carry-Infections', 'Smoke Inhalation Injury-exclude-Death', 'Death-found-Coronary Artery Disease', 'Death-found-Aortic Valve Stenosis', 'Coronary Artery Disease-found-Aortic Valve Stenosis', 'Coronary Artery Disease-found-Heart Diseases', 'Carcinogenesis-include-Neoplasms', 'Atrial Fibrillation-manifest-Stroke', 'Pain-manage-Arthritis', 'Atrial Fibrillation-defined-Arrhythmias, Cardiac', 'Atrial Fibrillation-include-Cardiomyopathy, Hypertrophic', 'Atrial Fibrillation-include-Cardiomyopathy, Dilated', 'Atrial Fibrillation-include-Pericarditis', 'Atrial Fibrillation-include-Ventricular Dysfunction', 'Atrial Fibrillation-imply-Hyperthyroidism', 'Atrial Fibrillation-imply-Sick Sinus Syndrome', 'Death-lower-Pneumonia', 'Pulmonary Disease, Chronic Obstructive-enhanced-Periodontal Diseases', 'Pulmonary Disease, Chronic Obstructive-enhanced-Alveolar Bone Loss', 'Pulmonary Disease, Chronic Obstructive-assess-Alveolar Bone Loss', 'Inflammation-contribute-Hyperglycemia', 'Periodontal Diseases-assess-Alveolar Bone Loss', 'Alveolar Bone Loss-contribute-Hyperglycemia', 'Diabetes Mellitus-contribute-Hyperglycemia', 'Alveolar Bone Loss-associated-Pulmonary Disease, Chronic Obstructive', 'Pulmonary Disease, Chronic Obstructive-associated-Alveolar Bone Loss', 'Alveolar Bone Loss-increase-Pulmonary Disease, Chronic Obstructive', 'Coronary Artery Disease-accompany-Hypertension', 'Cardiac Complexes, Premature-improve-Seizures', 'Intestinal Obstruction-occur-Inflammation', 'Death-occur-Arthritis', 'Intestinal Obstruction-mimic-Appendicitis', 'Inflammation-mimic-Appendicitis', 'Rheumatic Diseases-follow-Arthritis', 'Airway Obstruction-occur-Chondrosarcoma', 'Coma-underestimate-Brain Injuries', 'Dementia-occur-Leukoencephalopathies', 'Leukoencephalopathies-measured-Cerebral Ventricle Neoplasms', 'Atrophy-measured-Cerebral Ventricle Neoplasms', 'Hypertension-exhibit-Heart Failure', 'Hypercholesterolemia-underlie-Atherosclerosis', 'Hypertension-underlie-Atherosclerosis', 'Diabetes Mellitus-underlie-Atherosclerosis', 'Infections-underlie-Atherosclerosis', 'Cerebral Amyloid Angiopathy-associated-Death', 'Death-associated-Cerebral Amyloid Angiopathy', 'Hemorrhage-associated-Infarction', 'Infarction-associated-Hemorrhage', 'Hemorrhage-referred-Cerebrovascular Disorders', 'Infarction-referred-Cerebrovascular Disorders', 'Microaneurysm-associated-Cerebrovascular Disorders', 'Cerebrovascular Disorders-associated-Microaneurysm', 'Drug Hypersensitivity-result-Liver Failure', 'Liver Diseases-reported-End Stage Liver Disease', 'Glucose Intolerance-include-Chronic Disease', 'Death-related-Postoperative Complications', 'Neoplasms-account-Adenocarcinoma', 'Carcinoma, Squamous Cell-account-Adenocarcinoma', 'Neoplasms-occur-Carcinoma, Squamous Cell', 'Carcinoma, Squamous Cell-occur-Salivary Gland Neoplasms', 'Chronic Disease-remain-Death', 'Oculocerebrorenal Syndrome-preserved-Bone Diseases, Metabolic', 'Oculocerebrorenal Syndrome-preserved-Drug-Related Side Effects and Adverse Reactions', 'Bone Diseases, Metabolic-preserved-Drug-Related Side Effects and Adverse Reactions', 'Hyperparathyroidism-caused-Parathyroid Neoplasms', 'Critical Illness-reported-Horner Syndrome', 'Horner Syndrome-reported-Paralysis', 'Horner Syndrome-reported-Parathyroid Neoplasms', 'Myelodysplastic Syndromes-confirmed-Leukemia, Myeloid, Acute', 'Leukemia, Myeloid, Acute-balanced-Drug-Related Side Effects and Adverse Reactions', 'Sleep Apnea, Obstructive-associated-Hypertension', 'Hypertension-associated-Sleep Apnea, Obstructive', 'Osteoporotic Fractures-compare-Osteoarthritis', 'Cardiovascular Diseases-follow-Hypertension', 'Coronary Artery Disease-reach-Stroke', 'Coronary Artery Disease-reach-Death', 'Heart Failure-claim-Death', 'Cross Infection-found-Infections', 'Blister-develop-Skin Diseases', 'Wounds and Injuries-induce-Nervous System Malformations', 'Wounds and Injuries-contribute-Pain, Postoperative', 'Wounds and Injuries-contribute-Pain', 'Nervous System Malformations-enhance-Pain, Postoperative', 'Nervous System Malformations-contribute-Pain, Postoperative', 'Nervous System Malformations-enhance-Pain', 'Nervous System Malformations-contribute-Pain', 'Hypertension-underlie-Heart Diseases', 'Diabetes Mellitus-underlie-Heart Diseases', 'Hyperlipidemias-underlie-Heart Diseases', 'Zollinger-Ellison Syndrome-characterized-Peptic Ulcer', 'Zollinger-Ellison Syndrome-characterized-Pancreatic Neoplasms', 'Alzheimer Disease-exhibit-Psychomotor Agitation', 'Myalgia-affect-Polymyalgia Rheumatica', 'Muscle Weakness-affect-Polymyalgia Rheumatica', 'Retropharyngeal Abscess-presented-Craniocerebral Trauma', 'Pneumothorax-observed-Lung Diseases', 'Pneumothorax-observed-Lung Injury', 'Central Serous Chorioretinopathy-found-Choroidal Neovascularization', 'Pancreatic Neoplasms-accompanied-Fibrosis', 'Neoplasm Invasiveness-accompanied-Fibrosis', 'Petrositis-confirm-Cushing Syndrome', 'Neoplasms-study-Breast Neoplasms', 'Hypertension-produce-Kidney Failure, Chronic', 'Hypertension-produce-Heart Failure', 'Bone Neoplasms-attribute-Hepatitis E', 'Diabetic Nephropathies-associated-Diabetes Mellitus, Type 1', 'Diabetes Mellitus, Type 1-associated-Diabetic Nephropathies', 'Stroke-related-Diabetes Mellitus', 'Alzheimer Disease-determine-Hallucinations', 'Infections-monitor-Death', 'Alzheimer Disease-represent-Psychoses, Substance-Induced', 'Infections-diminish-Immune System Diseases', 'Edema-recognized-Asphyxia', 'Edema-lead-Asphyxia', 'Edema-recognized-Angioedemas, Hereditary', 'Asphyxia-recognized-Angioedemas, Hereditary', 'Asphyxia-lead-Angioedemas, Hereditary', 'Spinal Cord Diseases-related-Pain', 'Angioedemas, Hereditary-precipitate-Disseminated Intravascular Coagulation', 'Angioedemas, Hereditary-precipitate-Multiple Organ Failure', 'Stomach Neoplasms-account-Pleural Effusion, Malignant', 'Lymphoma-account-Pleural Effusion, Malignant', 'Diabetes Mellitus-show-Diabetic Foot', 'Migraine Disorders-report-Headache', 'Migraine Disorders-terminate-Stroke', 'Headache-terminate-Migraine Disorders', 'Headache-become-Stroke', 'Migraine Disorders-comprise-Headache', 'Migraine Disorders-compare-Headache', 'Migraine Disorders-decrease-Headache', 'Headache-replace-Migraine Disorders', 'Headache-consist-Migraine Disorders', 'Intracranial Arteriosclerosis-decline-Stroke', 'Intracranial Arteriosclerosis-decline-Stroke, Lacunar', 'Intracranial Arteriosclerosis-decline-Brain Diseases', 'Intracranial Arteriosclerosis-decline-Migraine Disorders', 'Intracranial Arteriosclerosis-accentuated-Migraine Disorders', 'Stroke-decline-Brain Diseases', 'Stroke-decline-Migraine Disorders', 'Stroke, Lacunar-decline-Brain Diseases', 'Stroke, Lacunar-decline-Migraine Disorders', 'Brain Diseases-decline-Migraine Disorders', 'Brain Diseases-accentuated-Migraine Disorders', 'Stroke-cause-Atrial Flutter', 'Stroke-cause-Cardiomyopathies', 'Stroke-cause-Arrhythmias, Cardiac', 'Atrial Fibrillation-cause-Cardiomyopathies', 'Atrial Flutter-precipitate-Heart Failure', 'Atrial Flutter-cause-Cardiomyopathies', 'Atrial Flutter-cause-Arrhythmias, Cardiac', 'Urinary Incontinence-fit-Seizures', 'Renal Insufficiency-lead-Stupor', 'Rothmund-Thomson Syndrome-investigate-Death', 'Retinitis-contribute-Macular Degeneration', 'Carcinogenesis-lead-Multiple Myeloma', 'Constriction, Pathologic-receive-Hypotension', 'Heart Failure-thrive-Immunologic Deficiency Syndromes', 'Kidney Tubular Necrosis, Acute-diagnosed-Acute Kidney Injury', 'Death-considered-Kidney Tubular Necrosis, Acute', 'Wounds and Injuries-fall-Fractures, Bone', 'Hypertension-improve-Sleep Initiation and Maintenance Disorders', 'Aneurysm-increase-Glucose Intolerance', 'Aneurysm-increase-Diabetes Mellitus', 'Parkinsonian Disorders-observed-Dyskinesia, Drug-Induced', 'Parkinsonian Disorders-observed-Dystonia', 'Parkinsonian Disorders-observed-Muscle Cramp', 'Inflammation-trigger-Coronary Thrombosis', 'Alzheimer Disease-coexist-Dementia', 'Inflammation-trigger-Autoimmune Diseases', 'Coronary Thrombosis-trigger-Autoimmune Diseases', 'Coronary Thrombosis-trigger-Polyarteritis Nodosa', 'Inflammation-associated-Arterial Occlusive Diseases', 'Arterial Occlusive Diseases-associated-Inflammation', 'Multiple Myeloma-found-Neoplasms', 'Neoplasms-differ-Multiple Myeloma', 'Mastocytosis, Systemic-seen-Mitochondrial Diseases', 'Colonic Neoplasms-evaluate-Death', 'Neoplasms-afflicted-Colonic Neoplasms', 'Hepatitis E-contribute-Bone Neoplasms', 'Hypertension-divided-Hypertrophy, Left Ventricular', 'Infections-include-Gastrointestinal Diseases', 'Soft Tissue Infections-include-Infections', 'Soft Tissue Infections-include-Gastrointestinal Diseases', 'Hypertension-influence-Adenocarcinoma', 'Diabetes Mellitus-influence-Adenocarcinoma', 'Obesity-influence-Adenocarcinoma', 'Obesity-show-Gout', 'Hypertension-show-Gout', 'Parasitemia-associated-Anemia', 'Anemia-associated-Parasitemia', 'Malaria-include-Anemia', 'Malnutrition-include-Anemia', 'Alzheimer Disease-associated-Gait Disorders, Neurologic', 'Gait Disorders, Neurologic-associated-Alzheimer Disease', 'Hypertension-report-Headache', 'Hypertension-report-Fatigue', 'Hypertension-report-Dyspnea', 'Blindness-cause-Cataract', 'Pneumococcal Infections-conjugated-Tetany', 'Blindness-treat-Cataract', 'Blindness-reduce-Vision Disorders', 'Fractures, Bone-constitute-Myoclonus', 'Dementia-fear-Memory Disorders', 'Dementia-fear-Seizures', 'Ventricular Fibrillation-noted-Hypertrophy', 'Renal Insufficiency, Chronic-exist-Hypertension', 'Death-reduce-Renal Insufficiency', 'Euthyroid Sick Syndromes-associate-Endocrine System Diseases', 'Endocrine System Diseases-associate-Euthyroid Sick Syndromes', 'Atherosclerosis-produce-Carotid Artery Diseases', 'Hypertension-produce-Carotid Artery Diseases', 'Heart Diseases-examine-Obesity', 'Heart Diseases-examine-Hypertension', 'Epilepsy-compare-Coronary Artery Disease', 'Epilepsy-compare-Diabetes Mellitus', 'Coronary Artery Disease-caused-Dementia, Vascular', 'Gliosis-caused-Craniocerebral Trauma', 'Epilepsy-caused-Craniocerebral Trauma', 'Dyspepsia-lead-Death', 'Hemorrhage-lead-Death', 'Peptic Ulcer-relieve-Dyspepsia', 'Gastroesophageal Reflux-heal-Mucositis', 'Gastrointestinal Hemorrhage-include-Peptic Ulcer', 'Dyspepsia-include-Peptic Ulcer', 'Malabsorption Syndromes-caused-Gastritis, Atrophic', 'Death-reduced-Nephrotic Syndrome', 'Diabetes Mellitus-follow-Heart Failure', 'Fistula-demonstrated-Diabetes Mellitus', 'Colonic Neoplasms-reduce-Kidney Failure, Chronic', 'Lymphoma-belong-Neoplasms', 'Atrophy-known-Dysphonia', 'Tremor-followed-Paralysis', 'Dysphonia-followed-Paralysis', 'Ischemia-killed-Wounds and Injuries', 'Ischemia-observed-Basal Ganglia Diseases', 'Intracranial Hypertension-killed-Wounds and Injuries', 'Intracranial Hypertension-observed-Basal Ganglia Diseases', 'Wounds and Injuries-observed-Basal Ganglia Diseases', 'Wounds and Injuries-killed-Death', 'Asthma-mistaken-Pulmonary Disease, Chronic Obstructive', 'Asthma-assessed-Hypotension', 'Genetic Diseases, Inborn-implicated-Alzheimer Disease', 'Fractures, Bone-live-Heart Failure', 'Death-attributed-Status Epilepticus', 'Death-compare-Status Epilepticus', 'Kidney Diseases-recognized-Renal Insufficiency', 'Aneurysm-recognized-Renal Insufficiency', 'Death-increase-Ulcer', 'Basal Ganglia Diseases-occur-Alzheimer Disease', 'Psychoses, Substance-Induced-associated-Basal Ganglia Diseases', 'Basal Ganglia Diseases-associated-Psychoses, Substance-Induced', 'Dementia-suggest-Parkinson Disease', 'Dementia-characterised-Parkinson Disease, Secondary', 'Dementia-characterised-Hallucinations', 'Abnormalities, Drug-Induced-excluded-Craniocerebral Trauma', 'Hypoxia-potentiate-Respiratory Insufficiency', 'Hypercapnia-potentiate-Respiratory Insufficiency', 'Cerebral Amyloid Angiopathy-contribute-Stroke', 'Aneurysm-occur-Alzheimer Disease', 'Aneurysm-assessed-Fibrosis', 'Calcinosis-described-Cerebral Amyloid Angiopathy', 'Aneurysm-assessed-Inflammation', 'Aneurysm-assessed-Vasculitis, Central Nervous System', 'Calcinosis-described-Cerebral Hemorrhage', 'Cerebral Amyloid Angiopathy-described-Cerebral Hemorrhage', 'Aneurysm-assessed-Arterial Occlusive Diseases', 'Hematologic Diseases-worsen-Bone Marrow Failure Disorders', 'Hematologic Diseases-worsen-Leukemia, Myeloid, Acute', 'Hematologic Diseases-lead-Myelodysplastic Syndromes', 'Bone Marrow Failure Disorders-worsen-Leukemia, Myeloid, Acute', 'Hypertension-treat-Adrenal Insufficiency', 'Arthritis-decrease-Colonic Neoplasms', 'Colonic Neoplasms-reduce-Alzheimer Disease', 'Adenocarcinoma-compared-Endodermal Sinus Tumor', 'Adenocarcinoma-resemble-Endodermal Sinus Tumor', 'Primary Myelofibrosis-develop-Leukemia', 'Primary Myelofibrosis-arose-Neoplasms', 'Leukemia-arose-Neoplasms', 'Tachycardia, Ventricular-scheme-Ventricular Fibrillation', 'Intestinal Polyposis-associated-Olfaction Disorders', 'Olfaction Disorders-associated-Intestinal Polyposis', 'Olfaction Disorders-associated-Sinusitis', 'Sinusitis-associated-Olfaction Disorders', 'Cardiovascular Diseases-seen-Hypertension', 'Delirium-include-Metabolic Diseases', 'Delirium-include-Infections', 'Hyperthyroidism-attributed-Euthyroid Sick Syndromes', 'Renal Insufficiency-attributed-Euthyroid Sick Syndromes', 'Hypertension-play-Heart Failure', 'Osteoporosis-recognised-Death', 'Necrosis-sutured-Fractures, Bone', 'Cardiomyopathy, Hypertrophic-reverse-Hypertension', 'Breast Neoplasms-provided-Neoplasms', 'Liver Failure-influence-Death', 'Death-preexist-Liver Failure', 'Death-preexist-Fibrosis', 'Fibrosis-lead-Death', 'Fibrosis-lead-Liver Failure', 'Infections-present-Weight Loss', 'Infections-present-Signs and Symptoms, Respiratory', 'Infections-present-Candidiasis, Oral', 'Venous Thromboembolism-rose-Pulmonary Embolism', 'Fistula-require-Heart Failure', 'Celiac Disease-cause-Malabsorption Syndromes', 'Intestinal Atresia-cause-Malabsorption Syndromes', 'Stroke-remedy-Brain Ischemia', 'Paralysis-follow-Seizures', 'Peripheral Nervous System Diseases-cause-Muscle Weakness', 'Peripheral Nervous System Diseases-cause-Hypesthesia', 'Deglutition Disorders-concluded-Pneumonia, Aspiration', 'Deglutition Disorders-concluded-Pneumonia', 'Magnesium Deficiency-result-Neurodegenerative Diseases', 'Ocular Hypertension-revolutionize-Cataract', 'Hyperparathyroidism, Primary-characterized-Hypercalcemia', 'Hyperparathyroidism, Primary-lead-Hypercalcemia', 'Hyperparathyroidism, Primary-characterized-Hypophosphatemia', 'Hyperparathyroidism, Primary-lead-Hypophosphatemia', 'Hyperparathyroidism, Primary-associated-Cardiovascular Abnormalities', 'Cardiovascular Abnormalities-associated-Hyperparathyroidism, Primary', 'Hyperparathyroidism, Primary-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-Hyperparathyroidism, Primary', 'Hyperparathyroidism, Primary-associated-Heart Block', 'Heart Block-associated-Hyperparathyroidism, Primary', 'Hyperparathyroidism, Primary-associated-Arrhythmias, Cardiac', 'Arrhythmias, Cardiac-associated-Hyperparathyroidism, Primary', 'Hyperparathyroidism, Primary-associated-Hypertension', 'Hypertension-associated-Hyperparathyroidism, Primary', 'Hyperparathyroidism, Primary-associated-Cardiomegaly', 'Cardiomegaly-associated-Hyperparathyroidism, Primary', 'Hyperparathyroidism, Primary-associated-Calcinosis', 'Calcinosis-associated-Hyperparathyroidism, Primary', 'Hyperparathyroidism, Primary-associated-Heart Valve Diseases', 'Heart Valve Diseases-associated-Hyperparathyroidism, Primary', 'Heart Block-include-Cardiovascular Diseases', 'Calcinosis-include-Cardiovascular Diseases', 'Spondylosis-reveal-Osteoporotic Fractures', 'Wounds and Injuries-result-Cardiac Output, Low', 'Ulcer-occur-Atherosclerosis', 'Hypertension-develop-Aortic Diseases', 'Hypertension-associated-Endocrine System Diseases', 'Endocrine System Diseases-associated-Hypertension', 'Hypertension-associated-Gastrointestinal Diseases', 'Gastrointestinal Diseases-associated-Hypertension', 'Hypertension-associated-Central Nervous System Diseases', 'Central Nervous System Diseases-associated-Hypertension', 'Hypertension-associated-Hematologic Diseases', 'Hematologic Diseases-associated-Hypertension', 'Hypotension-recognized-Nervous System Diseases', 'Stroke-developed-Carotid Artery Thrombosis', 'Aortic Valve Stenosis-become-Death, Sudden', 'Stroke-compare-Carotid Artery Thrombosis', 'Dementia-related-Hypertension', 'Dementia-related-Atherosclerosis', 'Cerebral Amyloid Angiopathy-seen-Cerebral Hemorrhage', 'Nerve Degeneration-involve-Epilepsies, Myoclonic', 'Cerebral Amyloid Angiopathy-seen-Amyloidosis', 'Nerve Degeneration-involve-Heart Failure', 'Genetic Diseases, Inborn-involve-Epilepsies, Myoclonic', 'Genetic Diseases, Inborn-involve-Heart Failure', 'Liver Neoplasms-resemble-Alzheimer Disease', 'Neurodegenerative Diseases-demonstrated-Urinary Incontinence, Urge', 'Death-associated-Brain Damage, Chronic', 'Brain Damage, Chronic-associated-Death', 'Sleep Initiation and Maintenance Disorders-require-Sleep Wake Disorders', 'Arrhythmias, Cardiac-occur-Death', 'Death, Sudden-related-Seizures', 'Myoclonus-expend-Cardiovascular Diseases', 'Myoclonus-expend-Death', 'Infections-cultured-Klebsiella Infections', 'Cross Infection-cultured-Klebsiella Infections', 'Death-follow-Klebsiella Infections', 'Respiratory Insufficiency-assessed-Sleep Wake Disorders', 'Infections-associated-Peptic Ulcer', 'Peptic Ulcer-associated-Infections', 'Infections-evolve-Neoplasms', 'Stomach Neoplasms-divided-Stomach Ulcer', 'Stroke-apply-Hypertension', 'Myocardial Infarction-apply-Hypertension', 'Ventricular Dysfunction, Left-apply-Hypertension', 'Asthma-force-Leukoencephalopathies', 'Angina Pectoris-force-Leukoencephalopathies', 'Hip Fractures-sustain-Wounds and Injuries', 'Myocardial Infarction-force-Leukoencephalopathies', 'Dyspnea-treat-Heart Failure', 'Heart Failure-force-Leukoencephalopathies', 'Neuroma-associated-Neurofibroma', 'Neurofibroma-associated-Neuroma', 'Cardiovascular Diseases-provide-Arrhythmias, Cardiac', 'Neuroma-occur-Neurologic Manifestations', 'Myocardial Infarction-decrease-Ischemia', 'Alzheimer Disease-suffer-Voice Disorders', 'Dementia, Vascular-suffer-Voice Disorders', 'Uveitis-account-Herpes Zoster Ophthalmicus', 'Uveitis-account-Sarcoidosis', 'Uveitis-account-Spondylitis, Ankylosing', 'Uveitis-account-Birdshot Chorioretinopathy', 'Uveitis-presented-Panuveitis', 'Acquired Immunodeficiency Syndrome-implicated-Substance-Related Disorders', 'Coronary Artery Disease-selected-Angina Pectoris', 'Coronary Artery Disease-selected-Myocardial Infarction', 'Coronary Artery Disease-associated-Dyspnea', 'Dyspnea-associated-Coronary Artery Disease', 'Immunologic Deficiency Syndromes-associated-Ovarian Diseases', 'Ovarian Diseases-associated-Immunologic Deficiency Syndromes', 'Stroke-develop-Pneumonia', 'Pneumonia, Aspiration-associated-Cough', 'Cough-associated-Pneumonia, Aspiration', 'Hypotension-give-Death', 'Parkinson Disease-include-Dyskinesia, Drug-Induced', 'Parkinson Disease-include-Psychoses, Substance-Induced', 'Fractures, Bone-slow-Osteoporosis', 'Death-occur-Dwarfism, Pituitary', 'Leukemia, Myeloid, Acute-used-Death', 'Gastrointestinal Hemorrhage-referred-Dyspepsia', 'Osteoporosis-rise-Dementia', 'Osteoporosis-rise-Blindness', 'Heart Diseases-rise-Dementia', 'Heart Diseases-rise-Blindness', 'Foodborne Diseases-account-Death', 'Tension-Type Headache-report-Headache', 'Foodborne Diseases-continue-Death', 'Neoplasms-cultured-Werner Syndrome', 'Giant Cell Arteritis-considered-Psychoses, Substance-Induced', 'Death-become-Infections', 'Hypertension-observed-Disorders of Excessive Somnolence', 'Wounds and Injuries-study-Death', 'Coma-study-Death', 'Osteoporosis-characterized-Sexual Dysfunction, Physiological', 'Osteoporosis-play-Hyperparathyroidism', 'Hernia-found-Death', 'Congenital Abnormalities-associated-Death', 'Death-associated-Congenital Abnormalities', 'Tricuspid Valve Insufficiency-associate-Coronary Artery Disease', 'Coronary Artery Disease-associate-Tricuspid Valve Insufficiency', 'Hepatitis C-increase-Ataxia', 'Sleep Initiation and Maintenance Disorders-mount-Drug Hypersensitivity', 'Inflammatory Bowel Diseases-associated-Colonic Neoplasms', 'Colonic Neoplasms-associated-Inflammatory Bowel Diseases', 'Hematoma-tend-Abnormalities, Drug-Induced', 'Cardiovascular Diseases-reduce-Blindness', 'Sepsis-account-Meningococcal Infections', 'Myositis-search-Autoimmune Diseases', 'Onychomycosis-seen-Diabetes Mellitus', 'Onychomycosis-seen-Acquired Immunodeficiency Syndrome', 'Atherosclerosis-include-Hypercholesterolemia', 'Atherosclerosis-dominate-Lipid Metabolism Disorders', 'Atherosclerosis-include-Hypertriglyceridemia', 'Sensation Disorders-contribute-Deglutition Disorders', 'Sleep Disorders, Circadian Rhythm-present-Psychomotor Agitation', 'Alzheimer Disease-present-Psychomotor Agitation', 'Infections-managed-Diarrhea', 'Dementia, Vascular-known-Leukoaraiosis', 'Craniocerebral Trauma-brought-Cardiac Output, Low', 'Craniocerebral Trauma-fall-Cardiac Output, Low', 'Metabolism, Inborn Errors-associated-Acidosis, Lactic', 'Acidosis, Lactic-associated-Metabolism, Inborn Errors', 'Metabolism, Inborn Errors-associated-Abnormalities, Drug-Induced', 'Abnormalities, Drug-Induced-associated-Metabolism, Inborn Errors', 'Metabolism, Inborn Errors-associated-Death', 'Death-associated-Metabolism, Inborn Errors', 'Chest Pain-guide-Pneumonia', 'Sleep Wake Disorders-related-Blindness', 'Myelodysplastic Syndromes-presented-Fever', 'Drug-Related Side Effects and Adverse Reactions-consist-Pregnancy Complications, Infectious', 'Cardiovascular Diseases-assessed-Peripheral Arterial Disease', 'Death-assessed-Peripheral Arterial Disease', 'Lung Neoplasms-thought-Inflammation', 'Death-considered-Pneumonia', 'Alzheimer Disease-measured-Heredodegenerative Disorders, Nervous System', 'Osteoarthritis-distinguished-Pain', 'Substance-Related Disorders-modeled-Sleep Initiation and Maintenance Disorders', 'Craniocerebral Trauma-identified-Meningitis, Bacterial', 'Otitis-identified-Meningitis, Bacterial', 'Gastroenteritis-given-Infections', 'Gastroenteritis-transmit-Infections', 'Foodborne Diseases-manifest-Gastroenteritis', 'Gastroenteritis-spread-Infections', 'Hypertension-define-Coronary Artery Disease', 'Hypertension-define-Heart Failure', 'Angina Pectoris-associated-Heart Failure', 'Heart Failure-associated-Angina Pectoris', 'Ventricular Dysfunction, Left-diagnosed-Mitral Valve Insufficiency', 'Opportunistic Infections-related-HIV Infections', 'Neoplasms-receive-Malnutrition', 'Pain-indicated-Death', 'Ischemic Attack, Transient-established-Stroke', 'Pneumoconiosis-bear-Lung Neoplasms', 'Glucose Metabolism Disorders-decrease-Atherosclerosis', 'Lung Neoplasms-obliterate-Carcinogenesis', 'Lung Neoplasms-obliterate-Asbestosis', 'Carcinogenesis-masked-Fibrosis', 'Gastric Antral Vascular Ectasia-cause-Hemorrhage', 'Heart Failure-manage-Diabetes Mellitus, Type 1', 'Heart Diseases-manage-Diabetes Mellitus, Type 1', 'Diabetic Nephropathies-manage-Diabetes Mellitus, Type 1', 'Angina Pectoris-include-Hypertension', 'Tachycardia, Supraventricular-include-Hypertension', 'Nephrosclerosis-characterized-Necrosis', 'Death-derive-Cardiovascular Diseases', 'Dyspnea-develop-Mitral Valve Insufficiency', 'Pain-observed-Hypoparathyroidism', 'Hypoparathyroidism-diagnosed-Diabetes Mellitus', 'Hypertension-compare-Hypertrophy, Left Ventricular', 'Glaucoma-prevent-Vision Disorders', 'Neoplasms-characterized-Facial Pain', 'Mucositis-characterized-Facial Pain', 'Hematologic Diseases-characterized-Facial Pain', 'Mastocytosis, Systemic-characterized-Facial Pain', 'Hyperkalemia-avoid-Cardiac Complexes, Premature', 'Leukoencephalopathies-attributed-Alzheimer Disease', 'Hypertension-caused-Abortion, Threatened', 'Hypertension-caused-Leukoencephalopathies', 'Hypertension-constitute-Death', 'Drug Overdose-prevent-Coma', 'Drug Overdose-induce-Heart Diseases', 'Gastroesophageal Reflux-associated-Death', 'Death-associated-Gastroesophageal Reflux', 'Seizures-take-Drug Overdose', 'Tuberculosis-transmit-Infections', 'Tuberculosis-demonstrated-Infections', 'Tuberculosis-infect-Infections', 'Coronary Artery Disease-improve-Heart Failure', 'Coronary Artery Disease-attenuate-Ischemia', 'Acquired Immunodeficiency Syndrome-thrive-Diabetes Mellitus', 'Diabetes Mellitus-thrive-Liver Neoplasms', 'Diabetes Mellitus-thrive-HIV Wasting Syndrome', 'Lung Diseases-linked-Death', 'Death-predominate-Communicable Diseases', 'Death-cause-Wounds and Injuries', 'Atrioventricular Block-used-Renal Insufficiency', 'Cardiovascular Diseases-establish-Hypertension', 'Atrioventricular Block-used-Hyperkalemia', 'Atrioventricular Block-result-Heart Block', 'Cardiovascular Diseases-establish-Coronary Artery Disease', 'Cardiovascular Diseases-establish-Myocardial Infarction', 'Cardiovascular Diseases-establish-Heart Failure', 'Carcinoma, Basal Cell-increase-Neoplasms', 'Hyperthyroidism-include-Thyroid Diseases', 'Thyroid Neoplasms-include-Thyroid Diseases', 'Hyperthyroidism-characterized-Headache Disorders, Secondary', 'Hyperthyroidism-characterized-Drug-Related Side Effects and Adverse Reactions', 'Hyperthyroidism-characterized-Thyroid Neoplasms', 'Headache Disorders, Secondary-characterized-Drug-Related Side Effects and Adverse Reactions', 'Headache Disorders, Secondary-characterized-Thyroid Neoplasms', 'Melanoma-account-Death', 'Melanoma-account-Skin Neoplasms', 'Kidney Diseases-blunted-Hypertension', 'Hyperhomocysteinemia-associated-Cerebrovascular Disorders', 'Cerebrovascular Disorders-associated-Hyperhomocysteinemia', 'Immunologic Deficiency Syndromes-induce-Neurologic Manifestations', 'Immunologic Deficiency Syndromes-suffer-Dementia', 'Neurologic Manifestations-suffer-Dementia', 'Hyperhomocysteinemia-lead-Neurodegenerative Diseases', 'Hyperparathyroidism, Secondary-activate-Bone Diseases', 'Parkinson Disease-examine-Parkinsonian Disorders', 'Hyperparathyroidism, Secondary-contribute-Bone Diseases', 'Hypertension-begin-Muscle Cramp', 'Neoplasms-estimated-Stomach Neoplasms', 'Communicable Diseases-manage-Infections', 'Acromegaly-associated-Breast Neoplasms', 'Breast Neoplasms-associated-Acromegaly', 'Nevus, Blue-confused-Histiocytoma, Benign Fibrous', 'Nevus, Blue-confused-Neurofibroma', 'Malabsorption Syndromes-arise-Gastritis, Atrophic', 'Ischemia-afford-Reperfusion Injury', 'Angina Pectoris-involve-Ischemia', 'Angina Pectoris-afforded-Ischemia', 'Osteoporosis-defined-Bone Neoplasms', 'Carcinogenesis-exist-Carcinoma, Hepatocellular', 'Sexually Transmitted Diseases-acquire-HIV Infections', 'Hypothalamic Neoplasms-contain-Hypertrophy', 'Alzheimer Disease-exhibit-Atrophy', 'Atrophy-correlated-Alzheimer Disease', 'Atrophy-explain-Alzheimer Disease', 'Parasomnias-characterized-Sleep Wake Disorders', 'Parasomnias-associated-Myalgia', 'Myalgia-associated-Parasomnias', 'Breast Neoplasms-include-Hypothalamic Diseases', 'Melanoma-include-Hypothalamic Diseases', 'Neuroendocrine Tumors-include-Melanoma', 'Hypothalamic Diseases-compare-Neuroendocrine Tumors', 'Hypothalamic Diseases-include-Neuroendocrine Tumors', 'Alzheimer Disease-met-Dementia, Vascular', 'Skin Neoplasms-regress-Neuroblastoma', 'Dementia, Vascular-suggest-Infarction', 'Dementia, Vascular-suggest-Cerebral Amyloid Angiopathy', 'Acute Pain-limited-Fractures, Bone', 'Pain-experience-Fractures, Bone', 'Pain-multiplied-Fractures, Bone', 'Fractures, Bone-report-Back Pain', 'Hypogonadism-involve-Endocrine System Diseases', 'Hemolytic-Uremic Syndrome-occur-Purpura, Thrombotic Thrombocytopenic', 'Fecal Incontinence-diagnosed-Quadriplegia', 'Diarrhea-diagnosed-Quadriplegia', 'Ossification of Posterior Longitudinal Ligament-contain-Arthritis', 'Death-controlled-Chronic Disease', 'Neoplasms-followed-Infections', 'Heart Diseases-analyzed-Heart Failure, Diastolic', 'Atherosclerosis-ensue-Death', 'Atherosclerosis-ensue-Myocardial Infarction', 'Atherosclerosis-ensue-Neoplasms', 'Osteoporosis-ensue-Death', 'Osteoporosis-ensue-Myocardial Infarction', 'Osteoporosis-ensue-Neoplasms', 'Death-ensue-Myocardial Infarction', 'Death-ensue-Neoplasms', 'Obesity-improve-Hypotension', 'Coronary Artery Disease-sustain-Myocardial Infarction', 'Coronary Artery Disease-provoked-Ischemia', 'Gerstmann-Straussler-Scheinker Disease-display-Nerve Degeneration', 'Drug-Related Side Effects and Adverse Reactions-needed-Small Cell Lung Carcinoma', 'Death-searched-Diabetes Mellitus', 'Diabetes Mellitus, Type 2-searched-Diabetes Mellitus', 'Lung Injury-ventilated-Respiratory Distress Syndrome', 'Common Cold-ventilated-Respiratory Distress Syndrome', 'Lung Injury-seen-Respiratory Distress Syndrome', 'Lung Injury-seen-Hypercapnia', 'Cerebrovascular Disorders-evaluated-Hypertension', 'Cerebral Infarction-differ-Hypertension', 'Cerebrovascular Disorders-evaluated-Cerebral Infarction', 'Hypoxia-lead-Hypertension, Pulmonary', 'Hypoxia-lead-Heart Failure', 'Tetany-cause-Respiratory Insufficiency', 'Tetany-cause-Heart Arrest', 'Rupture-treated-Ovarian Neoplasms', 'Hypertension-impair-Cardiomyopathy, Dilated', 'Epilepsy-include-Cerebrovascular Disorders', 'Epilepsy-include-Dementia', 'Epilepsy-include-Infections', 'Epilepsy-include-Wounds and Injuries', 'Epilepsy-include-Alcoholism', 'Glaucoma-account-Vision Disorders', 'Diabetes Mellitus-account-Vision Disorders', 'Myocardial Infarction-receive-Glucose Metabolism Disorders', 'Heart Failure-predisposed-Hypertension', 'Heart Failure-predisposed-Coronary Artery Disease', 'Heart Failure-predisposed-Heart Valve Diseases', 'Tachycardia, Ventricular-occur-Myocardial Infarction', 'Shock-make-Acute Kidney Injury', 'Sepsis-make-Acute Kidney Injury', 'Hypoxia-make-Acute Kidney Injury', 'Kidney Diseases-make-Acute Kidney Injury', 'Inflammation-assessed-Infections', 'Pain-given-Osteoporosis', 'Fractures, Bone-suffer-Musculoskeletal Diseases', 'Kidney Failure, Chronic-use-Fistula', 'Kidney Failure, Chronic-use-Arteriovenous Fistula', 'Heart Failure-investigate-Diabetes Mellitus, Type 2', 'Heart Failure-constitute-Diabetes Mellitus, Type 2', 'Heart Failure-predict-Diabetes Mellitus, Type 2', 'Diabetes Mellitus, Type 2-predict-Diabetes Mellitus', 'Weight Gain-cause-Breast Neoplasms', 'Parkinson Disease-show-Stroke', 'Heart Failure-prevail-Myocardial Infarction', 'Epilepsy-approached-Epileptic Syndromes', 'Hypertension-examined-Glucose Metabolism Disorders', 'Atrial Fibrillation-lead-Ventricular Dysfunction, Left', 'Psychoses, Substance-Induced-correlated-Dementia', 'Death-increased-Anemia', 'Neoplasms-increased-Anemia', 'Plaque, Amyloid-studied-Alzheimer Disease', 'Respiratory Tract Diseases-increased-Anemia', 'Plaque, Amyloid-studied-Dementia', 'Heart Arrest-demonstrate-Cardiovascular Abnormalities', 'Carcinogenesis-occur-Liver Cirrhosis', 'Cardiac Output, Low-decrease-Cardiovascular Diseases', 'Cardiac Output, Low-decrease-Death', 'Lipid Metabolism Disorders-associated-Coronary Artery Disease', 'Coronary Artery Disease-associated-Lipid Metabolism Disorders', 'Communicable Diseases-continue-Neoplasms', 'Neoplasms-continue-Primary Immunodeficiency Diseases', 'Neoplasms-continue-Communicable Diseases', 'Death-come-Leukemia, Myeloid, Acute', 'Death-come-Hematologic Diseases', 'Peptic Ulcer-named-Ulcer', 'Adenocarcinoma-named-Ulcer', 'Aphasia-detect-Neoplasms', 'Urinary Tract Infections-include-Urinary Bladder Diseases', 'Cerebral Infarction-accompanied-Infarction', 'Brain Infarction-judged-Infarction', 'Fat Necrosis-increase-Diabetes Mellitus, Type 2', 'Heart Diseases-suspect-Syncope', 'Death-excluded-Neoplasms', 'Neoplasms-identified-Ulcer', 'Neoplasms-identified-Stomach Ulcer', 'Hepatitis C-compensate-Liver Diseases', 'Chemical and Drug Induced Liver Injury-associated-Liver Diseases', 'Liver Diseases-associated-Chemical and Drug Induced Liver Injury', 'Death-include-Myotonic Dystrophy', 'Myotonic Dystrophy-include-Sepsis', 'Multiple Myeloma-cause-Bone Diseases', 'Nerve Degeneration-include-Genetic Diseases, Inborn', 'Immune System Diseases-include-Genetic Diseases, Inborn', 'Diabetes Mellitus, Type 1-observed-Hypoglycemia', 'Diabetes Mellitus, Type 1-observed-Atrophy', 'Asbestosis-followed-Neoplasms', 'Silicosis-followed-Neoplasms', 'Death-standardize-Lung Neoplasms', 'Death-standardize-Neoplasms', 'Osteoarthritis-scored-Bone Neoplasms', 'Osteoporosis-excluded-Osteoarthritis, Spine', 'Osteoporotic Fractures-excluded-Osteoarthritis, Spine', 'Obesity, Abdominal-include-Chronic Disease', 'Dyslipidemias-include-Chronic Disease', 'Gastrointestinal Hemorrhage-prevent-Myocardial Infarction', 'Myocardial Infarction-prevent-Gastrointestinal Hemorrhage', 'Ganglioneuroblastoma-include-Neuroblastoma', 'Hypothalamic Diseases-promote-Hypothalamic Neoplasms', 'Death-treated-Kidney Failure, Chronic', 'Parkinson Disease-recognize-Aneurysm', 'Parkinson Disease-recognize-Shy-Drager Syndrome', 'Parkinson Disease-recognize-Supranuclear Palsy, Progressive', 'Parkinson Disease-recognize-Tremor', 'Cerebral Hemorrhage-account-Cerebral Amyloid Angiopathy', 'Cerebral Amyloid Angiopathy-account-Hemorrhage', 'Hemorrhage-occur-Microaneurysm', 'Hemorrhage-occur-Necrosis', 'Dementia-investigate-Alzheimer Disease', 'Fistula-limited-Inflammation', 'Fistula-limited-Radiation Injuries', 'Fistula-limited-Intestinal Obstruction', 'Fistula-limited-Neoplasms', 'Hypertension-induce-Cardiomegaly', 'Diabetic Nephropathies-attributed-Hypertension', 'Diabetic Nephropathies-occur-Diabetes Mellitus', 'Diabetic Nephropathies-occur-Diabetes Mellitus, Type 1', 'Ductus Arteriosus, Patent-complicated-Heart Valve Diseases', 'Arrhythmias, Cardiac-isolated-Ventricular Premature Complexes', 'Death-affect-Neoplasms', 'Tremor-confused-Parkinson Disease', 'Smoke Inhalation Injury-delay-Sepsis', 'Smoke Inhalation Injury-predict-Death', 'Hematuria-present-Dysuria', 'Heart Failure-defined-Ventricular Dysfunction, Left', 'Hyperlipidemias-lead-Obesity', 'Hyperlipidemias-lead-Glucose Metabolism Disorders', 'Death-shown-Prostatic Neoplasms', 'Nephrotic Syndrome-progress-Kidney Failure, Chronic', 'Stroke-prevent-Cardiovascular Diseases', 'Myelodysplastic Syndromes-combine-Hyperkinesis', 'Exanthema-caused-Mycoses', 'Exanthema-caused-Skin Diseases, Eczematous', 'Exanthema-caused-Arbovirus Infections', 'Myelodysplastic Syndromes-divide-Anemia', 'Skin Diseases-range-Melanoma', 'Myelodysplastic Syndromes-divide-Leukemia, Myelomonocytic, Juvenile', 'Hepatitis-influence-Neurodegenerative Diseases', 'Hepatitis-influence-Neoplasms', 'Hepatitis-influence-Cardiovascular Diseases', 'Hepatitis-influence-Cataract', 'Hepatitis-influence-Arthritis', 'Coronary Artery Disease-occur-Atherosclerosis', 'Skin Neoplasms-become-Neoplasms', 'Skin Neoplasms-become-Melanoma', 'Neoplasms-become-Melanoma', 'Melanoma-become-Death', 'Arteritis-include-Headache', 'Cerebrovascular Disorders-include-Headache', 'Pulmonary Disease, Chronic Obstructive-include-Headache', 'Hypercapnia-include-Headache', 'Heart Arrest-increase-Angina Pectoris', 'Atrial Fibrillation-promote-Heart Failure', 'Hodgkin Disease-derived-Neoplasms', 'Pain-associated-Venous Thrombosis', 'Venous Thrombosis-associated-Pain', 'Death-explained-Cardiovascular Diseases', 'Ischemia-related-Diabetes Mellitus', 'Ischemia-related-Coronary Artery Disease', 'Seizures-attributed-Stroke', 'Seizures-attributed-Wounds and Injuries', 'Seizures-attributed-Hematoma, Subdural', 'Seizures-attributed-Neurodegenerative Diseases', 'Seizures-attributed-Central Nervous System Infections', 'Dementia-tend-Epilepsy', 'Dementia-administered-Alzheimer Disease', 'Hip Fractures-suffer-Fractures, Bone', 'Seizures-associated-Weight Gain', 'Weight Gain-associated-Seizures', 'Delirium-interpreted-Dementia', 'Varicose Ulcer-combine-Ulcer', 'Retrograde Degeneration-avoid-Kidney Diseases', 'Hematologic Diseases-develop-Bacteremia', 'Hypotension-avoid-Kidney Diseases', 'Parkinson Disease-used-Psychoses, Substance-Induced', 'Parkinson Disease-used-Delirium', 'Jaundice-show-Inflammation', 'Solitary Fibrous Tumor, Pleural-characterized-Vascular Calcification', 'Chronic Disease-appear-Diabetes Mellitus', 'Diabetes Mellitus-associated-Amyloidosis', 'Amyloidosis-associated-Diabetes Mellitus', 'Diabetes Mellitus-observed-Muscle Cramp', 'Esophageal Neoplasms-considered-Hernia, Hiatal', 'Chondrocalcinosis-include-Osteoarthritis', 'Fibrosis-assess-Infections', 'Fibrosis-assess-Hepatitis C', 'Fibrosis-define-Infections', 'Nuchal Cord-include-Stomach Neoplasms', 'Nuchal Cord-include-Neoplasms', 'Nocturia-turn-Sleep-Wake Transition Disorders', 'Nocturia-turn-Back Pain', 'Nocturia-turn-Dystonia', 'Nocturia-turn-Parkinson Disease', 'Sleep Wake Disorders-found-Parkinson Disease', 'Sleep Wake Disorders-occur-Parkinson Disease', 'Parkinson Disease-caused-Nocturia', 'Parkinson Disease-caused-Pain', 'Erectile Dysfunction-include-Aneurysm', 'Sleep Wake Disorders-reduce-Nocturia', 'Parkinson Disease-reduce-Nocturia', 'Myocardial Infarction-escape-Communicable Diseases', 'Carcinoma, Squamous Cell-diagnosed-Neoplasms', 'Hemorrhage-caused-Ventricular Dysfunction, Left', 'Neoplasms-diagnosed-Tongue Neoplasms', 'Obesity-compared-Osteoarthritis', 'Hip Fractures-increase-Status Epilepticus', 'Opportunistic Infections-infected-HIV Infections', 'Cardiovascular Diseases-correlated-Death', 'Neurologic Manifestations-result-Memory Disorders', 'Aneurysm-reviewed-Arterial Occlusive Diseases', 'Hydrocephalus-reduced-Aneurysm', 'Hematoma-reduced-Aneurysm', 'Neoplasms-reconstitute-Autoimmune Diseases', 'Infections-follow-Death', 'Infections-depend-Death', 'Cystinuria-constitute-Metabolic Diseases', 'Acidosis, Renal Tubular-constitute-Metabolic Diseases', 'Hyperparathyroidism-constitute-Metabolic Diseases', 'Status Epilepticus-associated-Drug-Related Side Effects and Adverse Reactions', 'Drug-Related Side Effects and Adverse Reactions-associated-Status Epilepticus', 'Drug-Related Side Effects and Adverse Reactions-associated-Death', 'Death-associated-Drug-Related Side Effects and Adverse Reactions', 'Edema-include-Kidney Diseases', 'Liver Cirrhosis-include-Kidney Diseases', 'Pneumonia-characterized-Fever', 'Pneumonia-characterized-Leukocytosis', 'Nephritis, Interstitial-associated-Nephrotic Syndrome', 'Nephrotic Syndrome-associated-Nephritis, Interstitial', 'Nephrotic Syndrome-associated-Renal Insufficiency, Chronic', 'Renal Insufficiency, Chronic-associated-Nephrotic Syndrome', 'Williams Syndrome-characterized-Intellectual Disability', 'Williams Syndrome-characterized-Aneurysm', 'Williams Syndrome-characterized-Aortic Stenosis, Supravalvular', 'Congenital, Hereditary, and Neonatal Diseases and Abnormalities-characterized-Intellectual Disability', 'Congenital, Hereditary, and Neonatal Diseases and Abnormalities-characterized-Aneurysm', 'Congenital, Hereditary, and Neonatal Diseases and Abnormalities-characterized-Aortic Stenosis, Supravalvular', 'Aortic Stenosis, Supravalvular-include-Aneurysm', 'Fever-correlate-Death', 'Leukocytosis-correlate-Death', 'Headache-associate-Migraine Disorders', 'Migraine Disorders-associate-Headache', 'Hemorrhage-consist-Hematemesis', 'Headache-indicate-Hypertension', 'Hemorrhage-consist-Anemia', 'Hemorrhage-consist-Vision Disorders', 'Neoplasms-affect-Heart Neoplasms', 'Esophageal Neoplasms-affect-Heart Neoplasms', 'Urinary Bladder Diseases-prevent-Airway Obstruction', 'Polymyalgia Rheumatica-confirmed-Synovitis', 'Synovitis-associated-Polymyalgia Rheumatica', 'Polymyalgia Rheumatica-associated-Synovitis', 'Osteomalacia-cause-Osteoporosis', 'Diabetic Angiopathies-lead-Proteinuria', 'Atherosclerosis-precipitated-Hypertension', 'Drug-Related Side Effects and Adverse Reactions-prescribed-Musculoskeletal Pain', 'Kidney Diseases-vary-Diabetes Mellitus, Type 1', 'Dementia-increase-Constipation', 'Cardiomyopathy, Dilated-receive-Dementia', 'Obesity-modify-Hypertension', 'Atrial Fibrillation-investigate-Dementia', 'Fractures, Bone-suffer-Wounds and Injuries', 'Uveitis-result-Vision Disorders', 'Kidney Diseases-found-Renal Artery Obstruction', 'Kidney Diseases-found-Hypercalcemia', 'Stroke-live-Dementia', 'Dementia-associated-Fecal Incontinence', 'Fecal Incontinence-associated-Dementia', 'Bacteremia-associated-Infections', 'Infections-associated-Bacteremia', 'Bacteremia-represent-Endocarditis', 'Infections-represent-Endocarditis', 'Kidney Diseases-develop-Renal Insufficiency, Chronic', 'Atrophy-result-Vision Disorders', 'Diabetes Mellitus, Type 2-associated-Kidney Diseases', 'Kidney Diseases-associated-Diabetes Mellitus, Type 2', 'Carcinogenesis-clarify-Neoplasms', 'Hypotension-occur-Cardiomyopathy, Hypertrophic', 'Death-become-Neoplasms', 'Cardiovascular Diseases-become-Neoplasms', 'Dementia-determine-Alzheimer Disease', 'Peptic Ulcer-account-Gastrointestinal Hemorrhage', 'Kidney Diseases-prevent-Renal Insufficiency', 'Hypertension-distinguish-Basal Ganglia Cerebrovascular Disease', 'Hypertension-distinguish-Nephrosclerosis', 'Basal Ganglia Cerebrovascular Disease-distinguish-Nephrosclerosis', 'Bone Diseases, Metabolic-compared-Breast Neoplasms, Male', 'Gastroenteritis-result-Acute Kidney Injury', 'Acute Kidney Injury-associated-Multiple Organ Failure', 'Multiple Organ Failure-associated-Acute Kidney Injury', 'Tachycardia-provoke-Angina Pectoris', 'Tachycardia-provoke-Coronary Artery Disease', 'Angina Pectoris-provoke-Coronary Artery Disease', 'Vascular Calcification-described-Diabetes Mellitus', 'Ocular Hypertension-arise-Vision Disorders', 'Ocular Hypertension-associated-Retinal Diseases', 'Retinal Diseases-associated-Ocular Hypertension', 'Dementia-illustrated-Hallucinations', 'Hallucinations-seen-Parkinson Disease', 'Kidney Diseases-found-Diabetes Mellitus, Type 2', 'Ischemia-found-Diabetes Mellitus, Type 2', 'Diabetes Mellitus, Type 2-include-Diabetic Nephropathies', 'Leukocytosis-limited-Leukemia', 'Leukocytosis-display-Leukemia', 'Fractures, Stress-described-Tibial Fractures', 'Death-compare-Pelvic Neoplasms', 'Pelvic Neoplasms-admitted-Wounds and Injuries', 'Pelvic Neoplasms-contribute-Death', 'Brain Infarction-suffer-Delirium', 'Death-contribute-Pelvic Neoplasms', 'Sleep Initiation and Maintenance Disorders-develop-Delirium', 'Coronary Artery Disease-confer-Death', 'Peritoneal Neoplasms-compare-Diabetes Mellitus', 'Death-cross-tabulate-Breast Neoplasms', 'Werner Syndrome-accompanied-Atherosclerosis', 'Death-cross-tabulate-Neoplasms', 'Aging, Premature-accompanied-Atherosclerosis', 'Atherosclerosis-suspected-Diabetes Mellitus', 'Atherosclerosis-suspected-Hyperinsulinism', 'Joint Diseases-include-Musculoskeletal Diseases', 'Obesity-include-Musculoskeletal Diseases', 'Muscle Weakness-include-Musculoskeletal Diseases', 'Death-include-Dysentery', 'Hypertension-used-Nephritis', 'Dementia-influence-Pain', 'Dementia-respond-Pain', 'Death-attributed-Salmonella Infections', 'Fractures, Bone-recognized-Paralysis', 'Neoplasms-extracted-Drug-Related Side Effects and Adverse Reactions', 'Fractures, Bone-involve-Cardiac Output, Low', 'Fractures, Bone-increased-Spinal Cord Diseases', 'Wilms Tumor-fare-Neoplasms', 'Neoplasms-learned-Wilms Tumor', 'Death-result-Genetic Diseases, Inborn', 'Malnutrition-observed-Hip Fractures', 'Syncope-occur-Heart Diseases', 'Atrial Fibrillation-show-Wolff-Parkinson-White Syndrome', 'Heredodegenerative Disorders, Nervous System-cause-Apnea', 'Arteriosclerosis-cause-Apnea', 'Heredodegenerative Disorders, Nervous System-produce-Sleep Apnea Syndromes', 'Infarction-cause-Apnea', 'Neoplasms-cause-Apnea', 'Hemorrhage-cause-Apnea', 'Encephalitis-cause-Apnea', 'Poliomyelitis-cause-Apnea', 'Communicable Diseases-cause-Apnea', 'Sleep Apnea Syndromes-characterized-Apnea', 'Prostatic Hyperplasia-devised-Prostatitis', 'Gastrointestinal Hemorrhage-result-Neoplasms', 'Pain-find-Headache Disorders, Secondary', 'Mycoses-increase-Neoplasms', 'Pain-find-Diabetes Mellitus', 'Mycoses-increase-Acquired Immunodeficiency Syndrome', 'Neoplasms-include-Fasciculation', 'HIV Infections-include-Fasciculation', 'Neurologic Manifestations-created-Sarcoma', 'Diabetes Mellitus-accelerated-Death', 'Urinary Incontinence-lack-Urinary Bladder Diseases', 'Lung Diseases-continue-Death', 'Lung Diseases-continue-HIV Infections', 'Vision Disorders-caused-Retinal Diseases', 'Retinal Diseases-went-Vision Disorders', 'Kidney Diseases-lead-Drug-Related Side Effects and Adverse Reactions', 'Drug-Related Side Effects and Adverse Reactions-occur-Liver Failure', 'Pain-result-Neoplasm Metastasis', 'Neoplasms-result-Neoplasm Metastasis', 'Death-remain-Pneumonia', 'Death-remain-Bronchitis', 'Death-remain-Gastroenteritis', 'Neoplasms-remain-Bronchitis', 'Neoplasms-remain-Gastroenteritis', 'Alzheimer Disease-distinguish-Heart Diseases', 'Alzheimer Disease-found-Diabetes Mellitus', 'Hip Fractures-include-Chronic Disease', 'Hydrocephalus-characterized-Gait Disorders, Neurologic', 'Hypokinesia-found-Movement Disorders', 'Hypokinesia-cause-Hydrocephalus', 'Muscle Hypertonia-cause-Hydrocephalus', 'Hyperkinesis-cause-Hydrocephalus', 'Mesial Movement of Teeth-tend-Fractures, Bone', 'Death-performed-Stomach Neoplasms', 'Death-decline-Osteosarcoma', 'Blister-defined-Leukoencephalopathies', 'Cholecystitis, Acute-complicate-Gallstones', 'Parkinson Disease-related-Parkinsonian Disorders', 'Atrophy-related-Parkinson Disease', 'Memory Disorders-found-Parkinson Disease', 'Venous Thrombosis-suffer-Pulmonary Embolism', 'Stroke-compare-Coronary Artery Disease', 'Stroke-compare-Aneurysm', 'Coronary Artery Disease-compare-Aneurysm', 'Penile Induration-resolve-Sleep Initiation and Maintenance Disorders', 'Penile Induration-resolve-Wounds and Injuries', 'Renal Insufficiency-appear-Drug-Related Side Effects and Adverse Reactions', 'Diabetes Mellitus, Type 2-characterised-Adrenal Insufficiency', 'Pick Disease of the Brain-associated-Dementia', 'Dementia-associated-Pick Disease of the Brain', 'Metabolic Diseases-characterised-Adrenal Insufficiency', 'Immunologic Deficiency Syndromes-associated-Hip Fractures', 'Hip Fractures-associated-Immunologic Deficiency Syndromes', 'Dementia-reported-Cardiovascular Diseases', 'Cerebral Infarction-accompany-Hypotension, Orthostatic', 'Dementia, Vascular-reflect-Stroke', 'Thyroid Neoplasms-give-Neoplasms', 'Neoplasms-range-Hyperplasia', 'Hyperplasia-represent-Neoplasms', 'Neoplasms-show-Atrophy', 'Neoplasms-show-Hyperplasia', 'Atrophy-develop-Hyperplasia', 'Chest Pain-present-Angina Pectoris', 'Alzheimer Disease-base-Supranuclear Palsy, Progressive', 'Death-exhibit-Neoplasms', 'Death-exhibit-Coronary Artery Disease', 'Heart Block-investigate-Ocular Hypertension', 'Cataract-investigate-Ocular Hypertension', 'Vision Disorders-correct-Aphakia', 'Cataract-correct-Aphakia', 'Death-arise-Hip Fractures', 'Glucose Metabolism Disorders-accelerate-Diabetic Nephropathies', 'Hip Fractures-expected-Death', 'Heart Arrest-induced-Wounds and Injuries', 'Fibrosis-identify-Uterine Diseases', 'Diabetes Mellitus-reported-Dementia', 'Urinary Tract Infections-include-Renal Insufficiency', 'Infections-classified-Bacteriuria', 'Infections-classified-Cystitis', 'Infections-classified-Pyelonephritis', 'Infections-classified-Urinary Tract Infections', 'Lung Diseases-associated-Bronchial Spasm', 'Bronchial Spasm-associated-Lung Diseases', 'Lung Diseases-associated-Asthma', 'Asthma-associated-Lung Diseases', 'Pneumonia-associated-Malnutrition', 'Malnutrition-associated-Pneumonia', 'Pneumonia-associated-Hip Fractures', 'Hip Fractures-associated-Pneumonia', 'Death, Sudden-associated-Ventricular Fibrillation', 'Ventricular Fibrillation-associated-Death, Sudden', 'Coronary Artery Disease-attenuate-Atherosclerosis', 'Death-increase-Hyperlipidemias', 'Lipid Metabolism Disorders-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-Lipid Metabolism Disorders', 'Heart Failure-classified-Ischemia', 'Leukemia, Myeloid, Acute-fail-Myelodysplastic Syndromes', 'Leukemia, Myeloid, Acute-fail-Leukemia, Promyelocytic, Acute', 'Leukemia, Myeloid, Acute-divide-Myelodysplastic Syndromes', 'Myelodysplastic Syndromes-include-Leukemia, Myeloid, Acute', 'Leukemia, Myeloid, Acute-complicate-Fanconi Anemia', 'Myelodysplastic Syndromes-complicate-Fanconi Anemia', 'Fanconi Anemia-complicate-Genetic Diseases, Inborn', 'Fanconi Anemia-complicate-Hematologic Neoplasms', 'Hypertension-associated-Brain Infarction', 'Brain Infarction-associated-Hypertension', 'Hip Fractures-occur-Bone Neoplasms', 'Dementia-exclude-Brain Diseases', 'Pneumonia-divided-Cross Infection', 'Chemical and Drug Induced Liver Injury-underlie-Dementia', 'Cardiomyopathies-underlie-Dementia', 'Hypertension-underlie-Dementia', 'Ovarian Neoplasms-reveal-Chromosome Aberrations', 'Death-suggest-Fatigue', 'Xerostomia-reported-Diabetes Mellitus, Type 2', 'Hypoxia-initiate-Disseminated Intravascular Coagulation', 'Xerostomia-reported-Cardiovascular Diseases', 'Hypoxia-initiate-Myoglobinuria', 'Hypoxia-initiate-Renal Insufficiency', 'Hyperlactatemia-initiate-Disseminated Intravascular Coagulation', 'Hyperlactatemia-initiate-Myoglobinuria', 'Hyperlactatemia-initiate-Renal Insufficiency', 'Acidosis-initiate-Disseminated Intravascular Coagulation', 'Acidosis-initiate-Myoglobinuria', 'Acidosis-initiate-Renal Insufficiency', 'Dehydration-initiate-Disseminated Intravascular Coagulation', 'Dehydration-initiate-Myoglobinuria', 'Dehydration-initiate-Renal Insufficiency', 'Fever-initiate-Disseminated Intravascular Coagulation', 'Fever-initiate-Myoglobinuria', 'Fever-initiate-Renal Insufficiency', 'Rhabdomyolysis-initiate-Disseminated Intravascular Coagulation', 'Rhabdomyolysis-initiate-Renal Insufficiency', 'Leukemia-include-Leukemia, Myeloid', 'Dementia-surveyed-Alzheimer Disease', 'Death-vary-Cardiovascular Diseases', 'Urinary Incontinence-overlooked-Infections', 'Infections-overlooked-Urinary Incontinence', 'Cardiovascular Diseases-accepted-Angina Pectoris, Variant', 'Cardiovascular Diseases-accepted-Raynaud Disease', 'Carcinoma, Squamous Cell-increase-Adenocarcinoma', 'Renal Insufficiency-undergo-Hypertension', 'Hypertension-undergo-Atherosclerosis', 'Renal Insufficiency-undergo-Atherosclerosis', 'Hernia-recorded-Death', 'Death-attributed-Intracranial Aneurysm', 'Death-approach-Aneurysm', 'Bone Marrow Diseases-noted-Infections', 'Drug-Related Side Effects and Adverse Reactions-include-Mucositis', 'Colorectal Neoplasms-involve-Neoplasms', 'Bone Diseases, Metabolic-associate-Hereditary Angioedema Type III', 'Hereditary Angioedema Type III-associate-Bone Diseases, Metabolic', 'Periodontal Diseases-represent-Thromboembolism', 'Infections-represent-Thromboembolism', 'Cardiovascular Diseases-carry-Learning Disabilities', 'Colonic Neoplasms-present-Appendicitis', 'Diabetes Mellitus-found-Pulmonary Disease, Chronic Obstructive', 'Diabetes Mellitus-found-Neurodegenerative Diseases', 'Diabetes Mellitus-found-Heart Diseases', 'Diabetes Mellitus-found-Neoplasms', 'Diabetes Mellitus-found-Kidney Diseases', 'Cardiovascular Diseases-render-Hypotension', 'Heart Failure-render-Hypotension', 'Kidney Diseases-render-Hypotension', 'Peptic Ulcer-limited-Stomach Diseases', 'Peptic Ulcer-documented-Stomach Diseases', 'Prostatic Hyperplasia-caused-Acute Kidney Injury', 'Acute Kidney Injury-cause-Heart Failure', 'Acute Kidney Injury-cause-Diabetic Nephropathies', 'Acute Kidney Injury-cause-End Stage Liver Disease', 'End Stage Liver Disease-include-Renal Insufficiency, Chronic', 'Acute Kidney Injury-caused-Nephritis, Interstitial', 'Acute Kidney Injury-obtain-Skin Diseases', 'Glomerulonephritis-associated-Acute Kidney Injury', 'Acute Kidney Injury-associated-Glomerulonephritis', 'Glomerulonephritis-associated-Proteinuria', 'Proteinuria-associated-Glomerulonephritis', 'Acute Kidney Injury-progress-Kidney Tubular Necrosis, Acute', 'Death-associated-Kidney Tubular Necrosis, Acute', 'Kidney Tubular Necrosis, Acute-associated-Death', 'Acute Kidney Injury-associated-Kidney Tubular Necrosis, Acute', 'Kidney Tubular Necrosis, Acute-associated-Acute Kidney Injury', 'Dyskinesia, Drug-Induced-associated-Brain Damage, Chronic', 'Brain Damage, Chronic-associated-Dyskinesia, Drug-Induced', 'Urinary Incontinence-correlate-Hip Fractures', 'Hypertension-associated-Hypertrophy', 'Hypertrophy-associated-Hypertension', 'Dystonia-produce-Hypokinesia', 'Hypertension-cause-Tachycardia', 'Parkinsonian Disorders-suffer-Hypokinesia', 'Chondrocalcinosis-observed-Neoplasms', 'Arthritis-distinguish-Rheumatic Diseases', 'Myocardial Infarction-included-Cardiovascular Diseases', 'Angina Pectoris-included-Cardiovascular Diseases', 'Stroke-included-Cardiovascular Diseases', 'Heart Failure-included-Cardiovascular Diseases', 'Sepsis-occur-Cardiovascular Diseases', 'Sepsis-occur-Respiratory Insufficiency', 'Psychomotor Disorders-make-Heart Diseases', 'Hyperkinesis-lead-Hypopituitarism', 'Hemorrhage-follow-Wounds and Injuries', 'Hemorrhage-considered-Dementia', 'Cerebral Hemorrhage-considered-Dementia', 'Alzheimer Disease-label-Plaque, Amyloid', 'Hepatitis-include-Neoplasms', 'Cystic Fibrosis-include-Neoplasms', 'Autoimmune Diseases-include-Neoplasms', 'Asthma-appear-Respiratory Tract Diseases', 'Asthma-appear-Respiratory Insufficiency', 'Hip Fractures-treated-Pain', 'Pain-result-Fractures, Bone', 'Pain-result-Spinal Stenosis', 'Abnormalities, Drug-Induced-characterized-Alzheimer Disease', 'Intellectual Disability-characterized-Alzheimer Disease', 'Ocular Motility Disorders-define-Obesity', 'Bone Neoplasms-protect-Osteoporotic Fractures', 'Milk Hypersensitivity-studied-Diabetes Mellitus', 'Pain-persist-Neuralgia', 'Leukoencephalopathies-occur-Alzheimer Disease', 'Alzheimer Disease-exhibit-Plaque, Amyloid', 'Kidney Failure, Chronic-lead-Hypertension', 'Kidney Failure, Chronic-lead-Diabetes Mellitus', 'Kidney Diseases-lead-Diabetes Mellitus', 'Nephrotic Syndrome-misdiagnosed-Heart Failure', 'Embolism, Cholesterol-involve-Death', 'Brain Damage, Chronic-suffer-Brain Diseases', 'Neoplasm Metastasis-arise-Sarcoma', 'Neoplasm Metastasis-arise-Neoplasms', 'Constipation-appear-Gallstones', 'Constipation-associated-Gallstones', 'Gallstones-associated-Constipation', 'Kidney Diseases-include-Aneurysm', 'Rotavirus Infections-develop-Diarrhea', 'Cardiotoxicity-appear-Leukemia, Myeloid, Acute', 'Gastritis, Atrophic-verified-Achlorhydria', 'Arrhythmias, Cardiac-associated-Coronary Artery Disease', 'Coronary Artery Disease-associated-Arrhythmias, Cardiac', 'Headache Disorders, Secondary-improve-Coronary Artery Disease', 'Neoplasms-manifest-Pancytopenia', 'Infections-manifest-Pancytopenia', 'Fractures, Bone-account-Hip Fractures', 'Alzheimer Disease-cause-Language Disorders', 'Polyarteritis Nodosa-demonstrated-Vasculitis', 'Diabetes Mellitus-reveal-Vasculitis', 'Multifocal Choroiditis-reveal-Vasculitis', 'Vasculitis-performed-Pain', 'Brain Infarction-caused-Aneurysm', 'Nervous System Diseases-associated-Paraproteinemias', 'Paraproteinemias-associated-Nervous System Diseases', 'Language Disorders-contribute-Aphasia', 'Brain Infarction-developed-Aortic Aneurysm', 'Communicable Diseases-contract-HIV Infections', 'Intellectual Disability-speed-Psychomotor Disorders', 'Aneurysm-find-Calcinosis', 'Heart Diseases-include-Thromboembolism', 'Diabetes Mellitus, Type 1-compared-Kidney Diseases', 'Diabetes Mellitus, Type 1-compared-Diabetes Mellitus', 'Diabetic Nephropathies-develop-Diabetes Mellitus, Type 1', 'Diabetic Nephropathies-characterized-Hypertrophy', 'Diabetes Mellitus, Type 1-characterized-Hypertrophy', 'Diabetes Mellitus-made-Hypotension', 'Anemia-develop-Headache', 'Parkinson Disease-reduced-Alzheimer Disease', 'Dementia-reduced-Alzheimer Disease', 'Chemical and Drug Induced Liver Injury-include-Tuberculosis', 'Death-caused-Chemical and Drug Induced Liver Injury', 'Atrophy-suggest-Vision Disorders', 'Fractures, Stress-suspected-Pain', 'Fractures, Stress-suspected-Sleep Initiation and Maintenance Disorders', 'Stroke-include-Glucose Intolerance', 'Stroke-increase-Glucose Intolerance', 'Stroke-increase-Carotid Stenosis', 'Stroke-increase-Atrial Fibrillation', 'Carotid Stenosis-associated-Stroke', 'Stroke-associated-Carotid Stenosis', 'Hypertension-contribute-Hearing Loss', 'Syncope-identify-Death', 'Atrioventricular Block-identify-Death', 'Neoplasms-confined-Death', 'Diarrhea-classified-Colitis', 'Drug-Related Side Effects and Adverse Reactions-classified-Colitis', 'Dysentery, Amebic-associated-Liver Abscess', 'Liver Abscess-associated-Dysentery, Amebic', 'Dysentery, Amebic-associated-Abdominal Pain', 'Abdominal Pain-associated-Dysentery, Amebic', 'Dysentery, Amebic-associated-Leukocytosis', 'Leukocytosis-associated-Dysentery, Amebic', 'Dysentery, Amebic-associated-Hyponatremia', 'Hyponatremia-associated-Dysentery, Amebic', 'Dysentery, Amebic-associated-Hypokalemia', 'Hypokalemia-associated-Dysentery, Amebic', 'Dysentery, Amebic-associated-Hypoalbuminemia', 'Hypoalbuminemia-associated-Dysentery, Amebic', 'Autoimmune Diseases-proposed-Narcolepsy', 'Ischemia-brought-Atherosclerosis', 'Neoplasms-develop-Pelvic Neoplasms', 'Chronic Disease-reduce-Death', 'Ovarian Neoplasms-show-Pelvic Neoplasms', 'Hemolytic-Uremic Syndrome-determine-Hypertension', 'Tinnitus-produce-Migraine Disorders', 'Tinnitus-produce-Epilepsy', 'Tinnitus-produce-Epilepsy, Temporal Lobe', 'Tinnitus-produce-Craniocerebral Trauma', 'Tinnitus-know-Hearing Disorders', 'Hypertension-based-Hypertensive Encephalopathy', 'Hypertension-required-Hypertensive Encephalopathy', 'Stroke-based-Hypertensive Encephalopathy', 'Stroke-required-Hypertensive Encephalopathy', 'Hypertension-seen-Stroke', 'Stroke-seen-Hypertension', 'Hypertension-described-Cerebral Infarction', 'Hypertension-described-Hemorrhage', 'Hemorrhage-related-Aortic Diseases', 'Aortic Valve Stenosis-predict-Death', 'Aortic Valve Stenosis-tend-Death', 'X-Linked Combined Immunodeficiency Diseases-injected-Leukemia, Lymphocytic, Chronic, B-Cell', 'X-Linked Combined Immunodeficiency Diseases-develop-Lymphoma', 'Leukemia, Lymphocytic, Chronic, B-Cell-transplanted-X-Linked Combined Immunodeficiency Diseases', 'Leukemia, Lymphocytic, Chronic, B-Cell-fail-Cardiomyopathies', 'Leukemia, Lymphocytic, Chronic, B-Cell-supplemented-Cardiomyopathies', 'Leukemia, Lymphocytic, Chronic, B-Cell-thrive-Urinary Bladder Neoplasms', 'Cardiomyopathies-supplemented-Urinary Bladder Neoplasms', 'Cardiomyopathies-cultured-Urinary Bladder Neoplasms', 'Arthritis, Rheumatoid-show-Glycosuria', 'Papillomavirus Infections-found-Neoplasms', 'Papillomavirus Infections-found-Adenocarcinoma', 'Neoplasms-found-Adenocarcinoma', 'Muscle Hypertonia-lead-Urinary Incontinence', 'Urinary Incontinence-occur-Muscle Hypertonia', 'Urinary Bladder Neoplasms-cause-Urinary Incontinence', 'Tachycardia, Ventricular-approach-Dementia, Vascular', 'Diabetes Mellitus, Type 2-control-Hyperglycemia', 'Arrhythmias, Cardiac-predict-Stroke', 'Cardiomyopathies-reduce-Death', 'Arrhythmias, Cardiac-predict-Dementia, Vascular', 'Hyperglycemia-established-Diabetes Mellitus, Type 1', 'Hyperglycemia-established-Diabetes Mellitus, Type 2', 'Retinal Diseases-established-Diabetes Mellitus, Type 1', 'Retinal Diseases-established-Diabetes Mellitus, Type 2', 'Kidney Diseases-established-Diabetes Mellitus, Type 1', 'Kidney Diseases-established-Diabetes Mellitus, Type 2', 'Nervous System Diseases-established-Diabetes Mellitus, Type 1', 'Nervous System Diseases-established-Diabetes Mellitus, Type 2', 'Death-examined-Lung Neoplasms', 'Fractures, Bone-associated-Muscle Weakness', 'Muscle Weakness-associated-Fractures, Bone', 'Neoplasm Invasiveness-occur-Infections', 'Fasciitis, Necrotizing-occur-Shock, Septic', 'Keratosis, Seborrheic-caused-Neoplasms', 'Neoplasms-support-Paraneoplastic Syndromes', 'Headache-follow-Nausea', 'Kidney Diseases-administer-Infections', 'Nerve Degeneration-adapt-Hereditary Angioedema Type III', 'Ataxia Telangiectasia-characterized-Disease', 'Ataxia Telangiectasia-characterized-Lymphoma, T-Cell', 'Pulmonary Disease, Chronic Obstructive-suggest-Infections', 'Sleep Initiation and Maintenance Disorders-suggest-Peripheral Nervous System Diseases', 'Femoral Neuropathy-help-Peripheral Nervous System Diseases', 'Death-expected-HIV Infections', 'Death-confound-Hemophilia A', 'HIV Infections-confound-Hemophilia A', 'Stomach Neoplasms-registered-Neoplasms', 'Osteoporosis-account-Spinal Fractures', 'Muscular Dystrophy, Duchenne-classify-Osteoporosis', 'Hypertension-reduced-Stroke', 'Death-reduced-Stroke', 'Hypoalphalipoproteinemias-cause-Death', 'Leukemia, B-Cell-characterized-Splenomegaly', 'Ventricular Dysfunction, Left-compared-Heart Failure', 'Death-occur-Breast Neoplasms', 'Plaque, Atherosclerotic-assess-Stroke', 'Plaque, Atherosclerotic-explain-Stroke', 'Epilepsy-exclude-Seizures, Febrile', 'Seizures-exclude-Seizures, Febrile', 'Epilepsy-decrease-Seizures', 'Stroke-associated-Thrombophilia', 'Thrombophilia-associated-Stroke', 'Chest Pain-represent-Myocardial Infarction', 'Chest Pain-represent-Death', 'Myocardial Infarction-represent-Death', 'Weight Loss-increase-Hip Fractures', 'Peripheral Arterial Disease-manifest-Intermittent Claudication', 'Atherosclerosis-manifest-Intermittent Claudication', 'Cerebrovascular Disorders-decline-Alzheimer Disease', 'Parkinson Disease, Secondary-reduce-Neoplasms', 'Addison Disease-reduce-Neoplasms', 'Neoplasms-reduce-Hypokalemic Periodic Paralysis', 'Neoplasms-reduce-Alcoholism', 'Neoplasms-reduce-Obesity', 'Asthma-overshadowed-Heart Failure', 'Optic Neuropathy, Ischemic-develop-Edema', 'Aortic Aneurysm, Abdominal-used-Heart Diseases', 'Nephrotic Syndrome-present-Kidney Diseases', 'Nephrotic Syndrome-present-Amyloidosis', 'Nephrotic Syndrome-associated-Amyloidosis', 'Amyloidosis-associated-Nephrotic Syndrome', 'Aneurysm-distinguish-Hypertension', 'Nephrotic Syndrome-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-Nephrotic Syndrome', 'Nephrotic Syndrome-associated-Neoplasms', 'Neoplasms-associated-Nephrotic Syndrome', 'Muscular Disorders, Atrophic-overestimated-Hypertension', 'Muscular Disorders, Atrophic-overestimated-Proteinuria', 'Muscular Disorders, Atrophic-overestimated-Nephrosclerosis', 'Proteinuria-overestimated-Nephrosclerosis', 'Hypotension-lead-Myocardial Infarction', 'Infections-hospitalized-Diarrhea', 'Infections-accompanied-Diarrhea', 'Diarrhea-accompanied-Infections', 'Rotavirus Infections-appear-Zoonoses', 'Immunologic Deficiency Syndromes-combined-Fatigue Syndrome, Chronic', 'Diarrhea-diagnose-Infections', 'Angina Pectoris-present-Syncope', 'Ulcer-remain-Spinal Cord Injuries', 'Bone Neoplasms-prevent-Hip Fractures', 'Vision Disorders-occur-Parkinson Disease', 'Retinitis-provide-Parkinson Disease', 'Leukoencephalopathies-demonstrate-Atrophy', 'Alzheimer Disease-demonstrate-Atrophy', 'Cardiovascular Diseases-related-Atherosclerosis', 'Atrophy-include-Leukoencephalopathies', 'Sleep Wake Disorders-implicated-Cardiovascular Diseases', 'Death-account-Death, Sudden', 'Death-account-Arrhythmias, Cardiac', 'Heart Failure-abolish-Arrhythmias, Cardiac', 'Shock-include-Alzheimer Disease', 'Bone Neoplasms-play-Osteoporosis', 'Metabolic Diseases-appear-Alzheimer Disease', 'Arthritis-affect-Pain', 'Arthritis-affect-Hypotension', 'Alzheimer Disease-receive-Renal Insufficiency', 'Renal Insufficiency-receive-Diabetes Mellitus, Type 2', 'Drug-Related Side Effects and Adverse Reactions-experience-Neutropenia', 'Headache Disorders, Secondary-include-Ovarian Diseases', 'Infertility, Female-include-Ovarian Diseases', 'Ovarian Diseases-include-Hemorrhage', 'Chiari-Frommel Syndrome-shown-Lupus Erythematosus, Systemic', 'Chiari-Frommel Syndrome-ameliorate-Lupus Erythematosus, Systemic', 'Pain-document-Diabetic Neuropathies', 'Death-compared-Retinal Diseases', 'Death-considered-Dermatomyositis', 'Death-considered-Polymyositis', 'Pulmonary Fibrosis-involved-Dermatomyositis', 'Pulmonary Fibrosis-involved-Polymyositis', 'Neoplasms-involved-Dermatomyositis', 'Calcinosis-tend-Dermatomyositis', 'Calcinosis-occur-Dermatomyositis', 'Neoplasms-involved-Polymyositis', 'Abdominal Pain-operated-Colitis, Ischemic', 'Diabetes Mellitus, Type 2-show-Hypertension', 'Hypertension-prevent-Diabetes Mellitus, Type 2', 'Aneurysm-prevent-Diabetes Mellitus, Type 2', 'Hypotension-prevent-Diabetes Mellitus, Type 2', 'Parkinson Disease-show-Huntington Disease', 'Huntington Disease-affected-Parkinson Disease', 'Immunologic Deficiency Syndromes-implicated-Hip Fractures', 'Immunologic Deficiency Syndromes-implicated-Osteoporotic Fractures', 'Bone Neoplasms-increase-Cardiac Output, Low', 'Femoral Neoplasms-reduce-Hip Fractures', 'Osteoporotic Fractures-cause-Pain', 'Hip Fractures-affect-Wounds and Injuries', 'Thyroid Hormone Resistance Syndrome-alter-Neoplasms', 'Hypothyroidism-become-Neoplasms', 'Carcinoma, Non-Small-Cell Lung-reported-Myxedema', 'Osteonecrosis-regarded-Fractures, Stress', 'Hypertension-confer-Stroke', 'Atrophy-show-Creutzfeldt-Jakob Syndrome', 'Obesity, Abdominal-associated-Coronary Artery Disease', 'Coronary Artery Disease-associated-Obesity, Abdominal', 'Obesity-classify-Obesity, Abdominal', 'Neoplasms-increased-Mouth Neoplasms', 'Myasthenia Gravis-characterized-Thymoma', 'Rothmund-Thomson Syndrome-characterized-Skin Abnormalities', 'Weight Loss-show-Hematoma, Subdural', 'Infections-occur-Sepsis', 'Genetic Diseases, Inborn-characterized-Skin Abnormalities', 'Chemical and Drug Induced Liver Injury-show-Fibrosis', 'Chemical and Drug Induced Liver Injury-show-Carcinoma, Hepatocellular', 'Hypogonadism-predispose-Osteoporosis', 'Taste Disorders-remain-Hyponatremia', 'Prostatic Neoplasms-set-Death', 'Hyponatremia-associated-Taste Disorders', 'Taste Disorders-associated-Hyponatremia', 'Wounds and Injuries-considered-Alzheimer Disease', 'Wounds and Injuries-considered-Craniocerebral Trauma', 'Carotid Stenosis-identified-Aneurysm', 'Hypertension-evaluated-Aneurysm', 'Cerebrovascular Disorders-continue-Death', 'Cerebrovascular Disorders-treat-Ischemia', 'Stroke-fell-Coronary Artery Disease', 'Arterial Occlusive Diseases-lead-Pain', 'Arterial Occlusive Diseases-lead-Gangrene', 'Diabetes Mellitus-lead-Pain', 'Diabetes Mellitus-lead-Gangrene', 'Ulcer-caused-Aneurysm', 'Postthrombotic Syndrome-cause-Ischemia', 'Wounds and Injuries-cause-Ischemia', 'Vasculitis-cause-Ischemia', 'Death-legitimize-Neoplasms', 'Dementia, Vascular-test-Dementia', 'Alzheimer Disease-test-Dementia, Vascular', 'Ulcer-diagnosed-Inflammation', 'Kidney Diseases-seen-Hypoxia', 'Airway Obstruction-studied-Signs and Symptoms, Respiratory', 'Signs and Symptoms, Respiratory-reported-Airway Obstruction', 'Immunologic Deficiency Syndromes-predispose-Fractures, Bone', 'Kidney Diseases-predispose-Fractures, Bone', 'Hyperparathyroidism-predispose-Fractures, Bone', 'Genetic Diseases, Inborn-associated-Retinal Vein Occlusion', 'Retinal Vein Occlusion-associated-Genetic Diseases, Inborn', 'Infertility, Female-affected-Azoospermia', 'Weight Loss-thrive-Muscle Weakness', 'Weight Loss-thrive-Fatigue', 'Hypothalamic Diseases-associated-Glucose Intolerance', 'Glucose Intolerance-associated-Hypothalamic Diseases', 'Weight Loss-fall-Pain', 'Hypothalamic Diseases-associated-Hyperlipidemias', 'Hyperlipidemias-associated-Hypothalamic Diseases', 'Weight Loss-consider-Infections', 'Hypothalamic Diseases-associated-Renal Insufficiency', 'Renal Insufficiency-associated-Hypothalamic Diseases', 'Muscle Weakness-consider-Infections', 'Fatigue-consider-Infections', 'Pain-consider-Infections', 'Fever-suspect-Infections', 'Fever-harbor-Infections', 'Sepsis-carry-Death', 'Cold Injury-increase-Communicable Diseases', 'Achlorhydria-caused-Gastrointestinal Diseases', 'Blind Loop Syndrome-caused-Gastrointestinal Diseases', 'Gastrointestinal Diseases-caused-Hypothyroidism', 'Carcinoma, Hepatocellular-promote-Hepatitis C', 'Hepatitis C-promote-Liver Diseases', 'Adrenocortical Carcinoma-performed-Death', 'Death-increased-Hypertrophy, Left Ventricular', 'Hypertrophy, Left Ventricular-lead-Ventricular Dysfunction', 'Hypertrophy, Left Ventricular-lead-Arrhythmias, Cardiac', 'Hypertrophy, Left Ventricular-increased-Coronary Artery Disease', 'Hypertrophy, Left Ventricular-reduce-Death', 'Death-compare-Infarction', 'Atherosclerosis-conquer-Coronary Artery Disease', 'Periodontal Diseases-measure-Periodontal Attachment Loss', 'Arthritis, Rheumatoid-selected-Lung Diseases', 'Osteomalacia-exacerbate-Osteoporosis', 'Adrenal Insufficiency-recognized-Bone Diseases, Metabolic', 'Fractures, Bone-imposed-Osteoporotic Fractures', 'Osteoporotic Fractures-imposed-Wounds and Injuries', 'Pneumonia, Pneumocystis-include-Infections', 'Pneumonia, Pneumocystis-include-Opportunistic Infections', 'Osteoporosis-prevent-Wounds and Injuries', 'Heart Diseases-include-Stroke', 'Colorectal Neoplasms-associated-Brain Neoplasms', 'Brain Neoplasms-associated-Colorectal Neoplasms', 'Brain Neoplasms-tend-Neoplasms', 'Brain Neoplasms-occur-Neoplasms', 'Neoplasms-tend-Glioblastoma', 'Carcinogenesis-underlie-Neoplasms', 'Myelodysplastic Syndromes-comprise-Bone Marrow Diseases', 'Myelodysplastic Syndromes-lead-Bone Marrow Diseases', 'Myelodysplastic Syndromes-divide-Leukemia, Myelomonocytic, Chronic', 'Hematologic Diseases-end-Leukemia, Myeloid', 'Myelodysplastic Syndromes-end-Leukemia, Myeloid', 'Coronary Artery Disease-imposed-Myocardial Infarction', 'Death-imposed-Myocardial Infarction', 'Aortic Aneurysm-found-Peripheral Vascular Diseases', 'Aortic Aneurysm-found-Hypertension', 'Glomerulonephritis, Membranous-account-Nephrotic Syndrome', 'Thromboembolism-result-Hypertension', 'Basal Ganglia Diseases-associated-Cardiac Output, Low', 'Cardiac Output, Low-associated-Basal Ganglia Diseases', 'Rhinitis-seen-Leukemic Infiltration', 'Sinusitis-seen-Leukemic Infiltration', 'Otitis-seen-Leukemic Infiltration', 'Hemoptysis-seen-Leukemic Infiltration', 'Osteoporosis-develop-Dementia', 'Alzheimer Disease-perform-Death', 'Leukemia, Myeloid, Acute-characterized-Myelodysplastic Syndromes', 'Drug-Related Side Effects and Adverse Reactions-complicate-Leukemia, Myeloid, Acute', 'Leukemia, Myeloid, Acute-characterized-Memory Disorders', 'Testicular Neoplasms-affect-Neoplasms', 'Pain-account-Osteoarthritis', 'Hypotension-reduce-Postpartum Hemorrhage', 'Li-Fraumeni Syndrome-lead-Adrenocortical Carcinoma', 'Neoplasms-appear-Polyps', 'Hypertension-persist-Diabetes Mellitus', 'Hypertension-suggest-Stroke, Lacunar', 'Stroke-correlate-Infarction', 'Stroke, Lacunar-indicate-Arteriolosclerosis', 'Stroke-co-exist-Infarction', 'Neoplasms-comprise-Carcinoma, Adenoid Cystic', 'Neoplasms-comprise-Carcinoma, Mucoepidermoid', 'Neoplasms-comprise-Chondrosarcoma', 'Carcinoma, Squamous Cell-comprise-Neoplasms', 'Carcinoma, Squamous Cell-comprise-Carcinoma, Adenoid Cystic', 'Carcinoma, Squamous Cell-comprise-Carcinoma, Mucoepidermoid', 'Carcinoma, Squamous Cell-comprise-Chondrosarcoma', 'Pain-arise-Inflammation', 'Osteoarthritis-arise-Inflammation', 'Osteoarthritis-play-Joint Diseases', 'Osteoarthritis-found-Weight Loss', 'Colonic Neoplasms-masquerade-Appendicitis', 'Colonic Neoplasms-masquerade-Appendiceal Neoplasms', 'Adenocarcinoma-present-Appendiceal Neoplasms', 'Adenocarcinoma-seem-Appendiceal Neoplasms', 'Cerebrovascular Disorders-become-Stroke', 'Stroke-examine-Death', 'Glucose Metabolism Disorders-decline-Alzheimer Disease', 'Cerebrovascular Disorders-decrease-Stroke', 'Drug Hypersensitivity-associated-Airway Obstruction', 'Airway Obstruction-associated-Drug Hypersensitivity', 'Glaucoma-show-Glaucoma, Neovascular', 'Death-assessed-Hypertension', 'Pigmentation Disorders-range-Death', 'Death-analysed-Colorectal Neoplasms', 'Death-connected-Neoplasms', 'Colorectal Neoplasms-connected-Neoplasms', 'Osteoarthritis-start-Pain', 'Hypertension-appear-Cardiovascular Diseases', 'Hypertension-suffer-Heart Valve Diseases', 'Fractures, Bone-investigate-Breast Neoplasms', 'Hypertension-investigated-Kidney Calculi', 'Headache Disorders, Secondary-equated-Brain Diseases', 'Dementia-diagnose-Headache Disorders, Secondary', 'Alzheimer Disease-related-Plaque, Amyloid', 'Lewy Body Disease-show-Alzheimer Disease', 'Lewy Body Disease-involved-Supranuclear Palsy, Progressive', 'Plaque, Amyloid-show-Neurodegenerative Diseases', 'Plaque, Amyloid-show-Dementia', 'Neurodegenerative Diseases-show-Dementia', 'Neurodegenerative Diseases-involve-Alzheimer Disease', 'Neurodegenerative Diseases-show-Alzheimer Disease', 'Parkinson Disease-involved-Supranuclear Palsy, Progressive', 'Nerve Degeneration-superimposed-Alzheimer Disease', 'Vision Disorders-superimposed-Alzheimer Disease', 'Cryptosporidiosis-mimic-Diarrhea', 'Hypertension-related-Plaque, Atherosclerotic', 'Kidney Diseases-related-Plaque, Atherosclerotic', 'Kidney Diseases-document-Hypertension', 'Acute Kidney Injury-include-Kidney Tubular Necrosis, Acute', 'Acute Kidney Injury-include-Glomerulonephritis', 'Pulmonary Disease, Chronic Obstructive-compared-Dementia', 'Dementia, Vascular-defined-Cerebral Infarction', 'Death-occur-Meningeal Neoplasms', 'Hemorrhage-occur-Meningeal Neoplasms', 'Meningeal Neoplasms-shrunk-Neoplasms', 'Brain Edema-persist-Neoplasms', 'Ankle Fractures-stimulated-Alzheimer Disease', 'Parkinson Disease-include-Arthritis', 'Spinal Osteophytosis-elevate-Fractures, Bone', 'Carcinoma, Bronchogenic-compare-Neoplasms', 'Obesity-concealed-Diabetes Mellitus', 'Infections-affected-Hematologic Neoplasms', 'Lymphedema-permit-Edema', 'Infections-induced-Neutropenia', 'Neutropenia-become-Infections', 'Nephrotic Syndrome-prevail-Lupus Erythematosus, Systemic', 'Cataract-require-Cardiomyopathy, Dilated', 'Cockayne Syndrome-require-Cataract', 'Alzheimer Disease-drawn-Dementia', 'Dementia, Vascular-drawn-Dementia', 'Alzheimer Disease-study-Dementia', 'Alzheimer Disease-observed-Memory Disorders', 'Alzheimer Disease-found-Parkinson Disease', 'Carcinoma, Squamous Cell-arise-Radiodermatitis', 'Carcinoma, Squamous Cell-show-Aneuploidy', 'Radiodermatitis-show-Aneuploidy', 'Muscular Diseases-study-Dermatomyositis', 'Muscular Diseases-study-Polymyositis', 'Muscular Diseases-study-Myositis', 'Mitochondrial Diseases-occur-Muscular Diseases', 'Ischemia-contribute-Mitochondrial Diseases', 'Ischemia-contribute-Dermatomyositis', 'Coma-diagnosed-Hyperglycemia', 'Coma-diagnosed-Ketosis', 'Ischemia-cause-Kidney Failure, Chronic', 'Ischemia-cause-Atherosclerosis', 'Azotemia-include-Kidney Diseases', 'Atherosclerosis-include-Kidney Diseases', 'Kidney Diseases-estimated-Atherosclerosis', 'Kidney Diseases-estimated-Hypertension', 'Atherosclerosis-estimated-Hypertension', 'Kidney Diseases-defined-Renal Artery Obstruction', 'Osteoarthritis, Hip-examined-Deafness', 'Alcohol Withdrawal Seizures-treat-Liver Diseases', 'Alcohol Withdrawal Seizures-result-Nausea', 'Alcohol Withdrawal Seizures-result-Vomiting', 'Alcohol Withdrawal Seizures-result-Diarrhea', 'Alcohol Withdrawal Seizures-result-Muscle Weakness', 'Alcohol Withdrawal Seizures-result-Tremor', 'Alcohol Withdrawal Seizures-result-Tachycardia', 'Alcohol Withdrawal Seizures-result-Hypertension', 'Alcohol Withdrawal Seizures-result-Psychomotor Agitation', 'Jaw Diseases-result-Tooth Loss', 'Alcohol Withdrawal Seizures-result-Delirium', 'Lupus Erythematosus, Systemic-distinguish-Exanthema', 'Alcohol Withdrawal Seizures-result-Hallucinations', 'Alcohol Withdrawal Seizures-result-Seizures', 'Lymphadenopathy-occur-Lupus Erythematosus, Systemic', 'Alcohol Withdrawal Seizures-result-Death', 'Hypertension-occur-Lupus Erythematosus, Systemic', 'Renal Insufficiency-occur-Lupus Erythematosus, Systemic', 'Osteoporosis-affect-Jaw Diseases', 'Osteoporotic Fractures-reduce-Death', 'Death-reduce-Alzheimer Disease', 'Dyspnea-tend-Infarction', 'Dyspnea-associated-Infarction', 'Infarction-associated-Dyspnea', 'Nausea-tend-Infarction', 'Nausea-associated-Infarction', 'Infarction-associated-Nausea', 'Vertigo-tend-Infarction', 'Vertigo-associated-Infarction', 'Infarction-associated-Vertigo', 'Syncope-tend-Infarction', 'Syncope-associated-Infarction', 'Infarction-associated-Syncope', 'Osteoarthritis-increase-Retinal Degeneration', 'Melanoma-occur-Cleft Palate', 'Tachycardia, Supraventricular-classified-Tachycardia', 'Tachycardia, Supraventricular-masquerade-Tachycardia', 'Tachycardia, Supraventricular-termed-Atrioventricular Block', 'Tachycardia, Supraventricular-termed-Tachycardia', 'Tachycardia, Supraventricular-masquerade-Tachycardia, Ventricular', 'Rheumatic Fever-objectify-Drug-Related Side Effects and Adverse Reactions', 'Paresthesia-burn-Muscle Weakness', 'Medulloblastoma-recognize-Neoplasms', 'Medulloblastoma-recognize-Lung Neoplasms', 'Neoplasms-reveal-Neuroectodermal Tumors', 'Neoplasms-reveal-Astrocytoma', 'Death-reveal-Neoplasms', 'Osteosarcoma-associated-Arthritis, Rheumatoid', 'Arthritis, Rheumatoid-associated-Osteosarcoma', 'Tetany-caused-Paralysis', 'Low Back Pain-studied-Death', 'Atherosclerosis-involved-Low Back Pain', 'Low Back Pain-studied-Cardiovascular Diseases', 'Low Back Pain-predict-Death', 'Diabetes Mellitus-associated-Insulin Resistance', 'Insulin Resistance-associated-Diabetes Mellitus', 'Infections-define-Bacteremia', 'Bone Neoplasms-associated-Hereditary Angioedema Type III', 'Hereditary Angioedema Type III-associated-Bone Neoplasms', 'Bone Neoplasms-lead-Spinal Fractures', 'Death-related-Multiple Organ Failure', 'Death-caused-Brain Injuries', 'Carotid Stenosis-found-Hypertension', 'Uterine Hemorrhage-associated-Neoplasms', 'Neoplasms-associated-Uterine Hemorrhage', 'Headache Disorders, Secondary-emerge-Esophageal Neoplasms', 'Cardiovascular Diseases-affect-Ulcer', 'Cardiovascular Diseases-affect-Headache Disorders, Secondary', 'Dementia-screen-Learning Disabilities', 'Obesity-explain-Death', 'Breast Neoplasms, Male-treated-Neoplasms', 'Death-exceed-Acquired Immunodeficiency Syndrome', 'Death-exceed-Substance-Related Disorders', 'Dementia-predict-Memory Disorders', 'Hypertension-cause-Sexual Dysfunction, Physiological', 'Sexual Dysfunction, Physiological-measured-Hypertension', 'Stroke-record-Death', 'Stroke-conceal-Cerebral Infarction', 'Tuberculosis-follow-Neoplasms', 'Pleural Effusion-followed-Neoplasms', 'Pleural Effusion-followed-Heart Failure', 'Tuberculosis-followed-Neoplasms', 'Tuberculosis-followed-Heart Failure', 'Infections-persist-Basal Ganglia Diseases', 'Retinal Diseases-correlated-Corneal Diseases', 'Wounds and Injuries-follow-Craniocerebral Trauma', 'Death-fell-Neoplasms', 'Death-fell-Leukemia', 'Pain-accept-Death', 'Heart Diseases-correlate-Drug-Related Side Effects and Adverse Reactions', 'Thyrotoxicosis-show-Tachycardia', 'Thyrotoxicosis-show-Weight Loss', 'Hypothermia-feel-Cold Injury', 'Coronary Artery Disease-smoking-Death', 'Diabetic Foot-related-Basal Ganglia Cerebrovascular Disease', 'Diabetic Foot-related-Diabetes Mellitus', 'Death-related-Basal Ganglia Cerebrovascular Disease', 'Diabetes Mellitus-exist-Ischemia', 'Nervous System Diseases-exist-Ischemia', 'Death-chart-Neoplasms', 'Neoplasms-chart-Death', 'Carotid Artery Diseases-prevent-Stroke', 'Carotid Artery Diseases-suggest-Constriction, Pathologic', 'Carotid Artery Diseases-shown-Stroke', 'Tuberculosis, Pulmonary-develop-Chemical and Drug Induced Liver Injury', 'Liver Diseases-develop-Chemical and Drug Induced Liver Injury', 'Drug Hypersensitivity-recognised-Syncope', 'Drug Hypersensitivity-associated-Coronary Artery Disease', 'Coronary Artery Disease-associated-Drug Hypersensitivity', 'Hypotension-compounded-Hypertension', 'Hypotension-compounded-Coronary Artery Disease', 'Hypotension-compounded-Cardiovascular Diseases', 'Drug Hypersensitivity-considered-Dementia, Vascular', 'Bradycardia-compounded-Cardiovascular Diseases', 'Diabetes Mellitus-include-Eye Diseases', 'Cardiovascular Diseases-result-Syncope, Vasovagal', 'Hereditary Breast and Ovarian Cancer Syndrome-include-Ulcer', 'Hereditary Breast and Ovarian Cancer Syndrome-take-Ulcer', 'Immunologic Deficiency Syndromes-include-Hereditary Breast and Ovarian Cancer Syndrome', 'Ulcer-take-Immunologic Deficiency Syndromes', 'Ulcer-take-Dementia', 'Asthma-diagnose-Signs and Symptoms, Respiratory', 'Xeroderma Pigmentosum-appear-Carcinoma, Basal Cell', 'Muscular Atrophy-associated-Neuromuscular Diseases', 'Neuromuscular Diseases-associated-Muscular Atrophy', 'Muscular Atrophy-define-Neuromuscular Diseases', 'Death-use-Coronary Artery Disease', 'Muscular Atrophy-perform-Sleep Initiation and Maintenance Disorders', 'Neuromuscular Diseases-lead-Sleep Initiation and Maintenance Disorders', 'Hip Fractures-comprise-Fractures, Bone', 'Tetany-related-Dystonia', 'Erectile Dysfunction-associated-Endocrine System Diseases', 'Endocrine System Diseases-associated-Erectile Dysfunction', 'Erectile Dysfunction-associated-Adrenal Gland Neoplasms', 'Adrenal Gland Neoplasms-associated-Erectile Dysfunction', 'Virilism-associated-Chronic Disease', 'Chronic Disease-associated-Virilism', 'Virilism-associated-Endocrine System Diseases', 'Endocrine System Diseases-associated-Virilism', 'Endocrine System Diseases-stemm-Adrenal Gland Neoplasms', 'Neurotoxicity Syndromes-mediated-Drug-Related Side Effects and Adverse Reactions', 'Death-attributed-Arthritis, Infectious', 'Arthritis, Infectious-remain-Communicable Diseases', 'Arthritis, Infectious-occur-Death', 'Arthritis, Infectious-remain-Joint Diseases', 'Arthritis, Infectious-portend-Death', 'Bronchitis-change-Infections', 'Dementia-suffer-Williams Syndrome', 'Pneumonia, Pneumocystis-considered-Lung Diseases', 'Pneumonia, Pneumocystis-considered-HIV Infections', 'Respiratory Tract Infections-complicate-HIV Infections', 'Infections-composed-Meningitis, Bacterial', 'Infections-composed-Tuberculosis', 'HIV Infections-composed-Meningitis, Bacterial', 'HIV Infections-composed-Tuberculosis', 'Colorectal Neoplasms-reach-Hodgkin Disease', 'Obesity-alter-Diabetes Mellitus', 'Prostatic Intraepithelial Neoplasia-associated-Neoplasms', 'Neoplasms-associated-Prostatic Intraepithelial Neoplasia', 'Prostatic Intraepithelial Neoplasia-develop-Prostatic Neoplasms', 'Obesity-influence-Diabetes Mellitus', 'Neurodegenerative Diseases-determine-Fractures, Bone', 'Infarction-relate-Epilepsy', 'Intracranial Hemorrhages-relate-Epilepsy', 'CADASIL-examine-Seizures', 'Epilepsy-examine-Seizures', 'Neurologic Manifestations-examine-Seizures', 'Epilepsy-develop-Seizures', 'Cardiomyopathy, Hypertrophic-associated-Hypertrophy', 'Hypertrophy-associated-Cardiomyopathy, Hypertrophic', 'Heart Failure-act-Cardiac Output, Low', 'Osteoporosis-develop-Osteomalacia', 'Movement Disorders-occur-Dyskinesia, Drug-Induced', 'Diabetes Mellitus, Type 2-lack-Heart Failure', 'Cartilage Diseases-exhibit-Neurodegenerative Diseases', 'Prostatic Hyperplasia-cause-Urinary Retention', 'Prostatic Hyperplasia-cause-Nocturia', 'Hypertension-determine-Stroke', 'Hypertension-determine-Death', 'Dementia-listed-Death', 'Death-recorded-Dementia', 'Chronic Disease-deteriorate-Death', 'Dementia, Vascular-associated-Dementia', 'Dementia-associated-Dementia, Vascular', 'Hypertension-stress-Dementia, Vascular', 'Nasal Obstruction-decrease-Inflammation', 'Sinusitis-decrease-Inflammation', 'Epilepsy-expressed-Consciousness Disorders', 'Asthma-underlie-Sinusitis', 'Dementia-exemplified-Alzheimer Disease', 'Headache Disorders, Secondary-experience-Osteoporosis', 'Adenomatous Polyps-repeat-Hemorrhage', 'Angiodysplasia-repeat-Hemorrhage', 'Colonic Polyps-induce-Postpartum Hemorrhage', 'Colonic Polyps-caused-Angiodysplasia', 'Postpartum Hemorrhage-caused-Angiodysplasia', 'Neoplastic Syndromes, Hereditary-cause-Cushing Syndrome', 'Stomach Ulcer-develop-Hemorrhage', 'Death-elevated-Respiratory Tract Diseases', 'Dementia-base-Alzheimer Disease', 'Dementia, Vascular-base-Alzheimer Disease', 'Atrial Fibrillation-associated-Cardiomyopathy, Dilated', 'Cardiomyopathy, Dilated-associated-Atrial Fibrillation', 'Respiratory Insufficiency-occur-Infections', 'Aortic Valve Insufficiency-limit-Headache Disorders, Secondary', 'Blood Platelet Disorders-associated-Coronary Artery Disease', 'Coronary Artery Disease-associated-Blood Platelet Disorders', 'Blood Platelet Disorders-associated-Death', 'Death-associated-Blood Platelet Disorders', 'Blood Platelet Disorders-show-Hemorrhage', 'Thyroid Neoplasms-seen-Neoplasms', 'Brucellosis-remain-Zoonoses', 'Echinococcosis-remain-Zoonoses', 'Alcoholism-contribute-Delirium', 'Hypoxia-contribute-Delirium', 'Hypotension-contribute-Delirium', 'Arteriolosclerosis-double-Alzheimer Disease', 'Arrhythmias, Cardiac-result-Neurologic Manifestations', 'Death-recorded-Thrombocytopenia', 'Death-increased-Neurologic Manifestations', 'Wounds and Injuries-study-Hypotension', 'Hereditary Breast and Ovarian Cancer Syndrome-related-Rheumatic Diseases', 'Spondylarthropathies-include-Rheumatic Diseases', 'Arthritis, Rheumatoid-include-Rheumatic Diseases', 'Nerve Degeneration-associated-Neurotoxicity Syndromes', 'Neurotoxicity Syndromes-associated-Nerve Degeneration', 'Neurodegenerative Diseases-addressed-Nerve Degeneration', 'Shock-prevent-Multiple Organ Failure', 'Diarrhea-enrolled-Dehydration', 'Hypertension-benefit-Angina Pectoris', 'Anemia, Macrocytic-screen-Chemical and Drug Induced Liver Injury', 'Neurodegenerative Diseases-remain-Metabolic Diseases', 'Myelodysplastic Syndromes-screen-Chemical and Drug Induced Liver Injury', 'Arteritis-identified-Polymyalgia Rheumatica', 'Aneurysm-attribute-Atherosclerosis', 'Stroke-increase-Pressure Ulcer', 'Dementia-increase-Pressure Ulcer', 'Pressure Ulcer-increase-Neutropenia', 'Osteoporosis-directed-Muscular Dystrophy, Duchenne', 'Osteoporosis-maximize-Muscular Dystrophy, Duchenne', 'Headache Disorders, Secondary-detect-Hypertension', 'Muscular Dystrophy, Duchenne-encouraged-Weight Gain', 'Hypotension-compare-Heart Diseases', 'Hypotension-compare-Heart Failure', 'Hypotension-involve-Ventricular Fibrillation', 'Hypotension-involve-Cardiovascular Diseases', 'Hypotension-underlie-Cardiovascular Diseases', 'Ventricular Fibrillation-underlie-Cardiovascular Diseases', 'Hypotension-caused-Death', 'Hypotension-caused-Heart Diseases', 'Death-compare-Heart Diseases', 'Cerebrovascular Disorders-associated-Ischemia', 'Ischemia-associated-Cerebrovascular Disorders', 'Seizures-reduce-Bone Neoplasms', 'Cerebrovascular Disorders-associated-Thrombosis', 'Thrombosis-associated-Cerebrovascular Disorders', 'Cerebrovascular Disorders-associated-Nicolau Syndrome', 'Nicolau Syndrome-associated-Cerebrovascular Disorders', 'Cerebrovascular Disorders-associated-Hypertensive Encephalopathy', 'Hypertensive Encephalopathy-associated-Cerebrovascular Disorders', 'Ischemic Attack, Transient-characterised-Cerebrovascular Disorders', 'Intracranial Arteriosclerosis-associated-Hypertension', 'Hypertension-associated-Intracranial Arteriosclerosis', 'Intracranial Arteriosclerosis-associated-Ischemia', 'Ischemia-associated-Intracranial Arteriosclerosis', 'Intracranial Arteriosclerosis-associated-Cerebral Infarction', 'Cerebral Infarction-associated-Intracranial Arteriosclerosis', 'Intracranial Arteriosclerosis-associated-Thrombosis', 'Thrombosis-associated-Intracranial Arteriosclerosis', 'Intracranial Arteriosclerosis-associated-Nicolau Syndrome', 'Nicolau Syndrome-associated-Intracranial Arteriosclerosis', 'Subarachnoid Hemorrhage-affected-Stroke', 'Hyperinsulinism-caused-Nesidioblastosis', 'Wounds and Injuries-report-Fractures, Bone', 'Endocarditis-include-Heart Failure', 'Heart Failure-include-Neurologic Manifestations', 'Thrombosis-include-Heart Failure', 'Uterine Cervicitis-associated-Infections', 'Infections-associated-Uterine Cervicitis', 'Uterine Cervicitis-associated-Gonorrhea', 'Gonorrhea-associated-Uterine Cervicitis', 'Uterine Cervicitis-associated-Arbovirus Infections', 'Arbovirus Infections-associated-Uterine Cervicitis', 'Infections-associated-Edema', 'Edema-associated-Infections', 'Hypertension-induced-Hypertrophy', 'Osteoarthritis-described-Muscular Dystrophies', 'Neoplasms-suffer-Nervous System Diseases', 'Paralysis-recognize-Muscle Weakness', 'Colonic Neoplasms-assessed-Headache Disorders, Secondary', 'Colonic Neoplasms-assessed-Signs and Symptoms, Digestive', 'Osteoporosis-include-Thyroid Diseases', 'Diabetes Mellitus-include-Thyroid Diseases', 'Autoimmune Diseases-include-Thyroid Diseases', 'Dementia-include-Thyroid Diseases', 'Malnutrition-include-Thyroid Diseases', 'Job Syndrome-lead-Fractures, Bone', 'Huntington Disease-related-Gliosis', 'Respiratory Insufficiency-taken-Renal Insufficiency, Chronic', 'Parkinsonian Disorders-mistaken-Basal Ganglia Diseases', 'Basal Ganglia Diseases-mistaken-Parkinson Disease', 'Stroke-reduced-Death', 'Hypoglycemia-considered-Paresis', 'Paresis-mimic-Cerebrovascular Disorders', 'Hypoglycemia-mimic-Cerebrovascular Disorders', 'Endocarditis-found-Death', 'Death-exist-Heart Failure', 'Alcoholism-accelerate-Nerve Degeneration', 'Hypothalamic Diseases-damaged-Alcoholism', 'Infarction-activated-Gait Disorders, Neurologic', 'Ischemia-activated-Gait Disorders, Neurologic', 'Parkinson Disease, Secondary-include-Atrophy', 'Parkinson Disease, Secondary-trained-Movement Disorders', 'Pancreatitis-result-Death', 'Taste Disorders-admitted-Ulcer', 'Obesity-connected-Breast Neoplasms', 'Death-identified-Aortic Valve Insufficiency', 'Respiratory Tract Infections-associated-Immune System Diseases', 'Immune System Diseases-associated-Respiratory Tract Infections', 'Respiratory Tract Infections-associated-Malnutrition', 'Malnutrition-associated-Respiratory Tract Infections', 'Immunologic Deficiency Syndromes-include-Malnutrition', 'Death-used-Neoplasms', 'Death-used-Stomach Neoplasms', 'Neoplasms-used-Stomach Neoplasms', 'Aneurysm-lead-Subarachnoid Hemorrhage', 'Diabetes Mellitus-include-HIV Infections', 'Arrhythmias, Cardiac-treat-Heart Diseases', 'Arrhythmias, Cardiac-treat-Ischemia', 'Arrhythmias, Cardiac-treat-Ventricular Fibrillation', 'Edema-related-Fractures, Stress', 'Arthritis, Rheumatoid-develop-Muscle Weakness', 'Muscle Weakness-develop-Aortic Aneurysm, Abdominal', 'Polyneuropathies-screen-Sensation Disorders', 'Sensation Disorders-screen-Hypesthesia', 'Sensation Disorders-screen-Reflex, Abnormal', 'Diabetes Mellitus-found-Polyneuropathies', 'Blood Platelet Disorders-prolong-Hemorrhage', 'Hypotension-used-Postpartum Hemorrhage', 'Hypotension-limited-Hemorrhage', 'Hypotension-reduce-Hemorrhage', 'Cartilage Diseases-present-Chondromalacia Patellae', 'Osteoarthritis-present-Chondromalacia Patellae', 'Osteoporotic Fractures-occur-Osteoporosis', 'Cold Injury-follow-Headache', 'Cold Injury-follow-Cough', 'Abdominal Pain-followed-Cold Injury', 'Fever-follow-Headache', 'Abdominal Pain-follow-Headache', 'Abdominal Pain-follow-Cough', 'Headache-follow-Cough', 'Common Cold-follow-Fever', 'Blindness-involved-Death', 'Hypothalamic Neoplasms-compare-Muscle Hypertonia', 'Vertebrobasilar Insufficiency-result-Diabetes Mellitus', 'Nervous System Diseases-result-Diabetes Mellitus', 'Basal Ganglia Diseases-result-Nervous System Diseases', 'Diabetes Mellitus-result-Basal Ganglia Diseases', 'Huntington Disease-compared-Death', 'Carotid Artery Diseases-assessed-Constriction, Pathologic', 'Atherosclerosis-assessed-Constriction, Pathologic', 'Fever-collected-Malaria', 'Death-improve-Prostatic Neoplasms', 'Lymphoma, Follicular-represent-Hodgkin Disease', 'Infections-produce-Drug Hypersensitivity', 'Vision Disorders-culminate-Death', 'Hyperthyroidism-appear-Hip Fractures', 'Mesenteric Vascular Occlusion-underlie-Diabetes Mellitus', 'Stomach Neoplasms-show-Microsatellite Instability', 'Constipation-associated-Diverticular Diseases', 'Diverticular Diseases-associated-Constipation', 'Constipation-associated-Colitis, Ulcerative', 'Colitis, Ulcerative-associated-Constipation', 'Crohn Disease-introduce-Narcotic-Related Disorders', 'Crohn Disease-introduce-Sepsis', 'Crohn Disease-precede-Death', 'Death-attributed-Myocardial Infarction', 'Crohn Disease-undergo-Sepsis', 'Crohn Disease-undergo-Pulmonary Embolism', 'Death-warrant-Crohn Disease', 'Hematoma-considered-Wounds and Injuries', 'Coronary Artery Disease-compare-Heart Diseases', 'Coronary Artery Disease-compare-Hypertension', 'Adrenal Insufficiency-exacerbate-Osteoporosis', 'Adrenal Insufficiency-cause-Osteomalacia', 'Coronary Artery Disease-decline-Hypertension', 'Weight Loss-associate-Death', 'Death-associate-Weight Loss', 'Atrophy-associated-Precancerous Conditions', 'Precancerous Conditions-associated-Atrophy', 'Atrophy-associated-Stomach Neoplasms', 'Stomach Neoplasms-associated-Atrophy', 'Anemia, Pernicious-associated-Hyperplasia', 'Hyperplasia-associated-Anemia, Pernicious', 'Stomach Diseases-described-Multiple Endocrine Neoplasia Type 1', 'Stomach Diseases-described-Gastritis, Atrophic', 'Stomach Diseases-described-Genetic Diseases, Inborn', 'Death-decrease-Thromboembolism', 'Cerebral Hemorrhage-decrease-Thromboembolism', 'Cerebral Hemorrhage-decrease-Cardiovascular Diseases', 'Weight Loss-reflect-Death', 'Musculoskeletal Diseases-associated-Neuralgia', 'Neuralgia-associated-Musculoskeletal Diseases', 'Mitochondrial Diseases-play-Myositis', 'Mitochondrial Diseases-play-Polymyositis', 'Mitochondrial Diseases-play-Dermatomyositis', 'Edema-caused-Lymphedema', 'Cardiovascular Abnormalities-described-Parkinson Disease', 'Muscular Diseases-characterized-Mitochondrial Diseases', 'Muscular Diseases-result-Mitochondrial Diseases', 'Intermittent Claudication-predict-Death', 'Intermittent Claudication-predict-Myocardial Infarction', 'Intermittent Claudication-predict-Stroke', 'Intermittent Claudication-predict-Cardiovascular Diseases', 'Myocardial Infarction-become-Cardiovascular Diseases', 'Glucose Intolerance-progress-Hypertension', 'Hypertension-progress-Cardiomyopathy, Hypertrophic', 'Cardiomyopathies-trigger-Cardiovascular Diseases', 'Death-encountered-Neoplasms', 'Hypertension-assigned-Weight Loss', 'Giant Cell Arteritis-distinguish-Arteritis', 'Arthritis, Rheumatoid-develop-Bacteremia', 'Autoimmune Diseases-resemble-Lupus Erythematosus, Systemic', 'Fever-decrease-Death', 'Dehydration-decrease-Death', 'Neoplasms-saw-Carcinoma, Squamous Cell', 'Hypertension-restore-Kidney Diseases', 'Skin Diseases-affect-Blindness', 'Ventricular Dysfunction, Left-altered-Hypertension', 'Hypothyroidism-base-Goiter', 'Cardiovascular Diseases-experience-Substance-Related Disorders', 'Rheumatic Heart Disease-experience-Substance-Related Disorders', 'Hypertension-experience-Substance-Related Disorders', 'Venous Thrombosis-experience-Substance-Related Disorders', 'Coronary Artery Disease-examined-Death', 'Atherosclerosis-associated-Prostatic Neoplasms', 'Prostatic Neoplasms-associated-Atherosclerosis', 'Atherosclerosis-exist-Prostatic Neoplasms', 'Ataxia-measured-Fractures, Bone', 'Prostatic Neoplasms-suffer-Neoplasms', 'Xanthomatosis, Cerebrotendinous-show-Drug-Related Side Effects and Adverse Reactions', 'Xanthomatosis, Cerebrotendinous-show-Bone Marrow Diseases', 'Drug-Related Side Effects and Adverse Reactions-show-Bone Marrow Diseases', 'Arthritis-report-Angina Pectoris', 'Arthritis-report-Myocardial Infarction', 'Arthritis-report-Hypertension', 'Arthritis-report-Diabetes Mellitus', 'Arthritis-report-Stroke', 'Arthritis-report-Lung Diseases', 'Thyrotoxicosis-cause-Hyperthyroidism', 'Myocardial Infarction-assumed-Heart Failure', 'Myocardial Infarction-assumed-Coronary Artery Disease', 'Kidney Diseases-differ-Diabetes Mellitus', 'Kidney Diseases-differ-Glomerulonephritis', 'Colitis-lead-Death', 'Leukoencephalopathies-result-Dementia', 'Leukoencephalopathies-result-Nervous System Diseases', 'Arteriosclerosis-receive-Dementia, Vascular', 'Leukoencephalopathies-receive-Dementia, Vascular', 'Stroke, Lacunar-receive-Dementia, Vascular', 'Cross Infection-occur-Infections', 'Osteomyelitis-optimized-Bacteremia', 'Inflammation-cause-Lung Diseases', 'Myocardial Infarction-acquire-Immunologic Deficiency Syndromes', 'Myocardial Infarction-acquire-Neoplasms', 'Autoimmune Diseases-induce-Infections', 'Rheumatic Diseases-dominate-Arthritis', 'Arthritis-ignored-Osteoporosis', 'Lupus Erythematosus, Systemic-dominate-Arthritis', 'Chest Pain-determine-Coronary Artery Disease', 'Otosclerosis-include-Bone Diseases, Metabolic', 'Bone Diseases, Metabolic-associated-Hearing Loss, Central', 'Hearing Loss, Central-associated-Bone Diseases, Metabolic', 'Otosclerosis-associated-Hearing Loss, Central', 'Hearing Loss, Central-associated-Otosclerosis', 'Pulmonary Disease, Chronic Obstructive-evidence-Memory Disorders', 'Hypotension-cause-Ischemia', 'Fibrosis-suggest-Keratoconjunctivitis', 'Atrophy-suggest-Keratoconjunctivitis', 'Brain Diseases-contribute-Memory Disorders', 'Tremor-compare-Essential Tremor', 'Tremor-compare-Parkinson Disease', 'Tremor-compare-Supranuclear Palsy, Progressive', 'Essential Tremor-compare-Supranuclear Palsy, Progressive', 'Parkinson Disease-compare-Supranuclear Palsy, Progressive', 'Essential Tremor-compare-Parkinson Disease', 'Weight Loss-result-Hypotension, Orthostatic', 'Hyperthyroidism-caused-Graves Disease', 'Anemia-result-Postpartum Hemorrhage', 'Myelodysplastic Syndromes-recognized-Bone Marrow Failure Disorders', 'Myelodysplastic Syndromes-recognized-Leukemia, Myeloid, Acute', 'Osteoporosis-reveal-Fractures, Bone', 'Dementia, Vascular-show-Alzheimer Disease', 'Death-related-Thrombosis', 'Death-related-Intestinal Obstruction', 'Osteoporosis-prevent-Cardiovascular Diseases', 'Lupus Erythematosus, Systemic-evaluate-Neurologic Manifestations', 'Liver Abscess-present-Chemical and Drug Induced Liver Injury', 'Arthritis-thought-Osteoporosis', 'Respiratory Distress Syndrome-follow-Pain', 'Carpal Tunnel Syndrome-affect-Nervous System Diseases', 'Radial Neuropathy-prevent-Nervous System Diseases', 'Spinal Injuries-admitted-Spinal Cord Injuries', 'Hip Fractures-defined-Pain', 'Edema-associated-Heart Failure', 'Heart Failure-associated-Edema', 'Edema-associated-Kidney Diseases', 'Kidney Diseases-associated-Edema', 'Edema-associated-Chemical and Drug Induced Liver Injury', 'Chemical and Drug Induced Liver Injury-associated-Edema', 'Polycystic Kidney Diseases-potentiate-Wounds and Injuries', 'Wounds and Injuries-play-Polycystic Kidney Diseases', 'Parkinsonian Disorders-occur-Hypotension, Orthostatic', 'Prostatitis-related-Airway Obstruction', 'Fibrosis-demonstrated-Airway Obstruction', 'Streptococcal Infections-recognised-Neoplasm Invasiveness', 'Streptococcal Infections-underlie-Diabetes Mellitus', 'Streptococcal Infections-underlie-Neoplasms', 'Streptococcal Infections-underlie-Liver Diseases', 'Infections-include-Peritoneal Neoplasms', 'Cross Infection-occur-Streptococcal Infections', 'Weight Gain-result-Metabolic Diseases', 'Streptococcal Infections-identify-Infections', 'Chronic Disease-identify-Infections', 'Breast Neoplasms-present-Obesity', 'Hyperinsulinism-related-Obesity', 'Weight Gain-associated-Breast Neoplasms', 'Breast Neoplasms-associated-Weight Gain', 'Muscle Rigidity-predict-Appendicitis', 'Pain-predict-Appendicitis', 'Deglutition Disorders-underlie-Liver Cirrhosis', 'Prostatic Hyperplasia-relieve-Airway Obstruction', 'Neoplasms-noted-Leukemia', 'Neoplasms-noted-Breast Neoplasms', 'Neoplasms-managed-Pain', 'Asthma-report-Rhinitis, Allergic, Seasonal', 'Dyspnea-associated-Heart Failure', 'Heart Failure-associated-Dyspnea', 'Dyspnea-associated-Bronchitis', 'Bronchitis-associated-Dyspnea', 'Dyspnea-associated-Emphysema', 'Emphysema-associated-Dyspnea', 'Retinal Degeneration-increased-Diabetes Mellitus', 'Airway Obstruction-associated-Cough', 'Cough-associated-Airway Obstruction', 'Dyspnea-remain-Airway Obstruction', 'Dyspnea-report-Heart Failure', 'Dyspnea-report-Coronary Artery Disease', 'Cardiovascular Diseases-remain-Airway Obstruction', 'Retinal Degeneration-encountered-Polyneuropathies', 'Death-suffer-Atrial Fibrillation', 'Cerebral Infarction-suffer-Atrial Fibrillation', 'Hypothyroidism-suffer-Atrial Fibrillation', 'Abdominal Pain-involve-Fistula', 'Ulcer-known-Pressure Ulcer', 'Syncope-develop-Bradycardia', 'Death-identified-Gastrointestinal Hemorrhage', 'Death-receive-Gastrointestinal Hemorrhage', 'Kyphosis-examine-Cystic Fibrosis', 'Colorectal Neoplasms-account-Carcinoid Tumor', 'Carcinoid Tumor-account-Neoplasms', 'Adenocarcinoma-account-Colonic Neoplasms', 'Colonic Neoplasms-account-Neoplasms', 'Lung Diseases-become-Wounds and Injuries', 'Rib Fractures-become-Wounds and Injuries', 'Fractures, Bone-become-Wounds and Injuries', 'Inferior Wall Myocardial Infarction-block-Bundle-Branch Block', 'Death-improve-Myocardial Infarction', 'Inferior Wall Myocardial Infarction-include-Myocardial Infarction', 'Thrombosis-superimposed-Atherosclerosis', 'Hypertension-confer-Cardiovascular Diseases', 'Fractures, Bone-exclude-Neoplasms', 'Sclerosis-exclude-Neoplasms', 'Spinal Dysraphism-occur-Wounds and Injuries', 'Acute Disease-occur-Cerebral Infarction', 'Liver Failure-account-Death', 'Carcinoma, Hepatocellular-account-Death', 'Dementia-differentiate-Nervous System Diseases', 'Dementia-differ-Epilepsies, Partial', 'Arthritis-result-Alzheimer Disease', 'Neoplasms-resemble-Testicular Neoplasms', 'Neoplasms-found-Seminoma', 'Enterocolitis-include-Inflammatory Bowel Diseases', 'Colitis, Ischemic-include-Inflammatory Bowel Diseases', 'Diverticular Diseases-include-Inflammatory Bowel Diseases', 'Fibromuscular Dysplasia-account-Aneurysm', 'Atherosclerosis-account-Aneurysm', 'Hypertension-produce-Renal Insufficiency', 'Kidney Diseases-recognized-Aneurysm', 'Renal Insufficiency-recognized-Aneurysm', 'Atrial Fibrillation-show-Tachycardia', 'Pulmonary Edema-recognized-Aneurysm', 'Tricuspid Valve Insufficiency-associated-Heart Failure', 'Heart Failure-associated-Tricuspid Valve Insufficiency', 'Lung Diseases-lead-Tricuspid Valve Insufficiency', 'Hepatomegaly-produce-Tricuspid Valve Insufficiency', 'Lung Diseases-lead-Heart Failure', 'Atrial Fibrillation-produce-Tricuspid Valve Insufficiency', 'Heart Failure, Diastolic-produce-Tricuspid Valve Insufficiency', 'Thrombosis-accounted-Fistula', 'Death-attributed-Osteoporosis', 'Cholestasis, Extrahepatic-occur-Carcinoma, Hepatocellular', 'Wounds and Injuries-filled-Multiple Organ Failure', 'Cholestasis, Extrahepatic-associated-Carcinoma, Hepatocellular', 'Carcinoma, Hepatocellular-associated-Cholestasis, Extrahepatic', 'Psychomotor Agitation-prevent-Delirium', 'Autoimmune Diseases-produce-IgA Vasculitis', 'Renal Artery Obstruction-related-Renal Insufficiency', 'Pain-appear-Headache Disorders, Primary', 'Hypertension-suggest-Aneurysm', 'Azotemia-associated-Aneurysm', 'Aneurysm-associated-Azotemia', 'Hypertension-recognized-Kidney Diseases', 'Hypertension-recognized-Renal Insufficiency', 'Kidney Diseases-become-Renal Insufficiency', 'Plaque, Atherosclerotic-associated-Intracranial Arteriosclerosis', 'Intracranial Arteriosclerosis-associated-Plaque, Atherosclerotic', 'Plaque, Atherosclerotic-associated-Ischemia', 'Ischemia-associated-Plaque, Atherosclerotic', 'Plaque, Atherosclerotic-associated-Coronary Artery Disease', 'Coronary Artery Disease-associated-Plaque, Atherosclerotic', 'Orbital Diseases-obtained-Alzheimer Disease', 'Hypothalamic Neoplasms-affected-Alzheimer Disease', 'Albuminuria-found-Hypertension', 'Kidney Diseases-depend-Diabetes Mellitus', 'Albuminuria-occur-Nephrosclerosis', 'Muscular Dystrophy, Duchenne-associated-Hip Fractures', 'Hip Fractures-associated-Muscular Dystrophy, Duchenne', 'Albuminuria-indicate-Hypertension', 'Diverticulitis-complicated-Fistula', 'Diverticulitis-complicated-Peritoneal Neoplasms', 'Diverticular Diseases-include-Pain', 'Diverticular Diseases-include-Inflammation', 'Diverticular Diseases-include-Diverticulitis', 'Diverticular Diseases-include-Hemorrhage', 'Death-decrease-Tuberculosis', 'Tuberculosis-increase-Neoplasms', 'Tuberculosis-increase-Coronary Artery Disease', 'Tuberculosis-increase-Pneumonia', 'Dementia-seen-Delirium', 'Dementia-coexist-Delirium', 'Bone Diseases-result-Osteoporosis', 'Bone Diseases-result-Osteomalacia', 'Bone Diseases-result-Hypercalcemia', 'Bone Diseases-result-Hypocalcemia', 'Infections-ruled-Ulcer', 'Skin Ulcer-ruled-Ulcer', 'Thrombosis-accelerated-Diabetes Mellitus', 'Diabetes Mellitus-cause-Retinal Diseases', 'Thrombosis-result-Death', 'Diabetes Mellitus-cause-Kidney Diseases', 'Atherosclerosis-accelerated-Diabetes Mellitus', 'Thoracic Injuries-result-Rupture', 'Pneumonia-suggest-Pneumococcal Infections', 'Death-follow-Hypertension', 'Sleep Initiation and Maintenance Disorders-tolerate-Death', 'Stroke-treat-Hypertension', 'Spondylosis-lead-Intervertebral Disc Degeneration', 'Common Cold-lead-Intervertebral Disc Degeneration', 'Intellectual Disability-fulfill-Lennox Gastaut Syndrome', 'Epilepsy, Temporal Lobe-stare-Cardiac Output, Low', 'Epilepsy, Temporal Lobe-stare-Seizures', 'Cardiac Output, Low-stare-Seizures', 'Carcinoma, Non-Small-Cell Lung-give-Neoplasms', 'Foreign Bodies-deteriorate-Death', 'Hypertension-improve-Hypertension, Malignant', 'Cardiovascular Diseases-treated-Death', 'Heart Failure-benefit-Death', 'Hip Fractures-suffer-Necrosis', 'Diabetes Mellitus-report-Myocardial Infarction', 'Diabetes Mellitus-report-Stroke', 'Myocardial Infarction-report-Diabetes Mellitus', 'Stroke-report-Diabetes Mellitus', 'Hypertension-characterized-Cardiac Output, High', 'Urinary Incontinence-report-Diabetes Mellitus', 'Vascular Calcification-seen-Coronary Artery Disease', 'Vascular Calcification-associated-Arteriosclerosis', 'Arteriosclerosis-associated-Vascular Calcification', 'Vascular Calcification-associated-Angina Pectoris', 'Angina Pectoris-associated-Vascular Calcification', 'Arteriosclerosis-associated-Angina Pectoris', 'Angina Pectoris-associated-Arteriosclerosis', 'Vascular Calcification-seen-Diabetes Mellitus', 'Heart Arrest-survive-Communicable Diseases', 'Werner Syndrome-characterized-Glucose Intolerance', 'Werner Syndrome-characterized-Diabetes Mellitus', 'Pressure Ulcer-considered-Spinal Cord Injuries', 'Neoplasms-take-Drug-Related Side Effects and Adverse Reactions', 'Granuloma-decline-Infections', 'Immunologic Deficiency Syndromes-develop-Pulmonary Emphysema', 'Hypokinesia-suggest-Brain Diseases', 'Agranulocytosis-experience-Leukopenia', 'Atrophy-enlarged-Subarachnoid Hemorrhage', 'Parkinson Disease-indicate-Irritable Bowel Syndrome', 'Leg Injuries-present-Sleep Wake Disorders', 'Stomach Ulcer-show-Ulcer', 'Anemia-suffer-Autoimmune Diseases', 'Nephritis-suffer-Autoimmune Diseases', 'Serositis-suffer-Autoimmune Diseases', 'Hypothyroidism-indicate-Autoimmune Diseases', 'Uveitis-indicate-Autoimmune Diseases', 'Iridocyclitis-indicate-Autoimmune Diseases', 'Vomiting-note-Neoplasms', 'Dehydration-prevent-Acidosis', 'Diarrhea-relieve-Nausea', 'Diarrhea-relieve-Vomiting', 'Alzheimer Disease-combine-Atrophy', 'Cerebrovascular Disorders-consist-Cerebral Infarction', 'Cerebrovascular Disorders-consist-Cerebral Hemorrhage', 'Diabetes Mellitus-suffer-Renal Insufficiency', 'Diabetes Mellitus-found-Renal Insufficiency, Chronic', 'Renal Insufficiency, Chronic-admitted-Diabetes Mellitus', 'Chondrosarcoma-induce-Arthritis', 'Prostatic Hyperplasia-suggested-Hypertension', 'Language Disorders-demonstrate-Articulation Disorders', 'Nephrotic Syndrome-show-Amyloidosis', 'Bone Neoplasms-suffer-Osteosarcoma', 'Akathisia, Drug-Induced-appear-Intellectual Disability', 'Diabetes Mellitus-seem-Death', 'Subarachnoid Hemorrhage-estimate-Atrophy', 'Fractures, Bone-manage-Neoplasm Metastasis', 'Death-attributed-Cross Infection', 'Death-identify-Infections', 'Cross Infection-survive-Infections', 'Wounds and Injuries-repair-Fractures, Bone', 'Infections-associated-Neutropenia', 'Neutropenia-associated-Infections', 'Death-remain-Hypertension', 'Hypertension-isolate-Death', 'Amnesia-develop-Seizures', 'Ataxia-associated-Intellectual Disability', 'Intellectual Disability-associated-Ataxia', 'Ataxia-associated-Peripheral Nervous System Diseases', 'Peripheral Nervous System Diseases-associated-Ataxia', 'Psychomotor Disorders-combined-Liver Diseases', 'Psychomotor Disorders-presented-Liver Diseases', 'Psychomotor Disorders-combined-Pericardial Effusion', 'Psychomotor Disorders-presented-Pericardial Effusion', 'Psychomotor Disorders-increase-Hypoglycemia', 'Inflammation-blur-Asthma', 'Inflammation-blur-Bronchitis', 'Hypertension-develop-Hypokalemia', 'Brain Diseases-seen-Dementia', 'Hyperinsulinism-accompany-Obesity, Abdominal', 'Obesity, Abdominal-associated-Lipid Metabolism Disorders', 'Lipid Metabolism Disorders-associated-Obesity, Abdominal', 'Hyperinsulinism-associated-Lipid Metabolism Disorders', 'Lipid Metabolism Disorders-associated-Hyperinsulinism', 'Heart Failure-represent-Dyspnea', 'Heart Failure-associated-Hypertrophy', 'Hypertrophy-associated-Heart Failure', 'Heart Failure-associated-Airway Obstruction', 'Airway Obstruction-associated-Heart Failure', 'Dyspnea-associated-Hypertrophy', 'Hypertrophy-associated-Dyspnea', 'Dyspnea-represent-Hypertrophy', 'Dyspnea-associated-Angina Pectoris', 'Angina Pectoris-associated-Dyspnea', 'Dyspnea-associated-Syncope', 'Syncope-associated-Dyspnea', 'Infections-avoid-Cardiac Output, Low', 'Diabetes Mellitus, Type 2-address-Diabetes Mellitus', 'Fractures, Bone-classified-Wounds and Injuries', 'Fractures, Bone-sustain-Poliomyelitis', 'Leukemia, Lymphocytic, Chronic, B-Cell-documented-Death', 'Leukemia, Lymphocytic, Chronic, B-Cell-underlie-Death', 'Peptic Ulcer-recognized-Peritoneal Neoplasms', 'Peritoneal Neoplasms-result-Death', 'Pancreatic Neoplasms-occur-Gallstones', 'Gallstones-occur-Pancreatitis', 'Pneumonia-contract-Death', 'Cerebral Infarction-enter-Death', 'Death-performed-Thrombosis', 'Pulmonary Embolism-occur-Venous Thrombosis', 'Pulmonary Embolism-prevent-Venous Thrombosis', 'Diabetes Mellitus, Type 1-predispose-Hypertension', 'Diabetes Mellitus, Type 1-predispose-Microvascular Angina', 'Diabetes Mellitus, Type 1-predispose-Nervous System Diseases', 'Diabetes Mellitus, Type 2-predispose-Hypertension', 'Diabetes Mellitus, Type 2-predispose-Microvascular Angina', 'Diabetes Mellitus, Type 2-predispose-Nervous System Diseases', 'Renal Insufficiency-described-Hypertension', 'Renal Insufficiency-develop-Hypertension', 'Renal Insufficiency-described-Diabetes Mellitus', 'Renal Insufficiency-develop-Diabetes Mellitus', 'Cardiomyopathy, Hypertrophic-predispose-Cardiovascular Diseases', 'Metabolic Diseases-predispose-Cardiovascular Diseases', 'Drug-Related Side Effects and Adverse Reactions-implicated-Neoplasms', 'Arrhythmias, Cardiac-measure-Ventricular Dysfunction, Left', 'Cerebral Small Vessel Diseases-tend-Diabetes Mellitus', 'Leukoencephalopathies-include-Dementia', 'Dementia, Vascular-supposed-Hypertension', 'Dementia, Vascular-supposed-Diabetes Mellitus', 'Dementia, Vascular-include-Heart Diseases', 'Stroke-supposed-Hypertension', 'Stroke-supposed-Diabetes Mellitus', 'Stroke-supposed-Heart Diseases', 'Dementia, Vascular-differ-Stroke', 'Dementia, Vascular-found-Stroke', 'Conjunctival Diseases-undergo-Eyelid Diseases', 'Conjunctival Diseases-develop-Eyelid Diseases', 'Carcinoma, Hepatocellular-arise-Fibrosis', 'Carcinoma, Hepatocellular-arise-Hemochromatosis', 'Stomach Neoplasms-resemble-Ulcer', 'Carcinoma, Hepatocellular-arise-Hepatitis B', 'Fibrosis-arise-Hepatitis B', 'Hemochromatosis-arise-Hepatitis B', 'Weight Gain-limited-Carpal Tunnel Syndrome', 'Keratitis, Dendritic-related-Intellectual Disability', 'Hypercapnia-study-Stroke', 'Hypercapnia-present-Ischemic Attack, Transient', 'Stroke-present-Ischemic Attack, Transient', 'Death-occur-Ulcer', 'Hypothyroidism-develop-Epilepsy, Temporal Lobe', 'Alzheimer Disease-followed-Dementia, Vascular', 'Poliomyelitis-defined-Muscle Weakness', 'Poliomyelitis-defined-Fatigue', 'Poliomyelitis-defined-Pain', 'Muscle Weakness-recover-Poliomyelitis', 'Fatigue-recover-Poliomyelitis', 'Pain-recover-Poliomyelitis', 'Plaque, Amyloid-occur-Diabetes Mellitus', 'Plaque, Amyloid-occur-Primary Dysautonomias', 'Breast Neoplasms-provide-Prostatic Neoplasms', 'Dystonia-eliminate-Hyperkinesis', 'Colonic Neoplasms-investigated-Constipation', 'Spinal Stenosis-reduce-Calcinosis', 'Coronary Artery Disease-result-Osteoporosis', 'Coronary Artery Disease-result-Fractures, Bone', 'Death-result-Osteoporosis', 'Death-result-Fractures, Bone', 'Sleep Initiation and Maintenance Disorders-evaluate-Dementia', 'Sleep Initiation and Maintenance Disorders-evaluate-Restless Legs Syndrome', 'Sleep Initiation and Maintenance Disorders-evaluate-Sleep Apnea Syndromes', 'Chorea-disappear-Euthyroid Sick Syndromes', 'Chorea-demonstrated-Hyperthyroidism', 'Euthyroid Sick Syndromes-demonstrated-Hyperthyroidism', 'Chorea-appear-Hyperthyroidism', 'Colonic Neoplasms-recognized-Colitis', 'Colitis-recognized-Inflammatory Bowel Diseases', 'Werner Syndrome-accompanied-Diabetes Mellitus', 'Werner Syndrome-accompanied-Glucose Intolerance', 'Genetic Diseases, Inborn-accompanied-Diabetes Mellitus', 'Genetic Diseases, Inborn-accompanied-Glucose Intolerance', 'Hypercalcemia-lead-Nephrolithiasis', 'Weight Loss-reversed-Heart Block', 'Dyspepsia-reversed-Heart Block', 'Endocarditis-dominated-Heart Failure', 'Endocarditis-dominated-Arthralgia', 'Endocarditis-dominated-Myalgia', 'Atrophy-result-Demyelinating Diseases', 'Periodontitis-exhibit-Inflammation', 'Atrophy-result-Gliosis', 'Multiple Sclerosis-result-Demyelinating Diseases', 'Multiple Sclerosis-result-Gliosis', 'Pinealoma-expect-Atrophy', 'Calcinosis-compare-Atrophy', 'Pinealoma-found-Atrophy', 'Neurodegenerative Diseases-traced-Alzheimer Disease', 'Neurodegenerative Diseases-traced-Parkinson Disease', 'Dermatitis-include-Eczema', 'Eczema-form-Skin Diseases', 'Dermatitis-form-Skin Diseases', 'Melanoma-increase-Lung Neoplasms', 'Crystal Arthropathies-include-Rheumatic Diseases', 'Spondylitis, Ankylosing-include-Rheumatic Diseases', 'Melanoma-increase-Colorectal Neoplasms', 'Blindness-include-Glaucoma, Open-Angle', 'Blindness-include-Cataract', 'Weight Gain-develop-Neoplasms', 'Weight Gain-develop-Cardiovascular Diseases', 'Weight Gain-develop-Osteoporosis', 'Immunologic Deficiency Syndromes-aggravate-Diabetes Mellitus', 'Immunologic Deficiency Syndromes-aggravate-Hypertension', 'Immunologic Deficiency Syndromes-promote-Coronary Artery Disease', 'Bundle-Branch Block-present-Myocardial Infarction', 'Death-undergo-Cholecystitis', 'Cholecystitis-measure-Death', 'Kyphosis-associated-Osteoporosis', 'Osteoporosis-associated-Kyphosis', 'Kyphosis-associated-Osteoarthritis', 'Osteoarthritis-associated-Kyphosis', 'Osteoporosis-differ-Osteoarthritis', 'Memory Disorders-occur-Alzheimer Disease', 'Dementia-associated-Canavan Disease', 'Canavan Disease-associated-Dementia', 'Neurodegenerative Diseases-remain-Rheumatic Diseases', 'Abnormalities, Multiple-coupled-Bone Marrow Neoplasms', 'Rheumatic Diseases-remain-Heart Valve Diseases', 'Abnormalities, Multiple-contribute-Infections', 'Bone Marrow Neoplasms-contribute-Infections', 'Adenomatous Polyposis Coli-become-Staphylococcal Infections', 'Streptococcal Infections-become-Staphylococcal Infections', 'Heart Failure-identify-Cardiomyopathy, Hypertrophic', 'Heart Failure-identify-Hypertension', 'Stroke-quantified-Death', 'Bacteriuria-decrease-Death', 'Infections-include-Hematoma', 'Vocal Cord Paralysis-include-Hematoma', 'Adenomatous Polyposis Coli-provide-Neoplasms', 'Adenomatous Polyposis Coli-provide-Prostatic Hyperplasia', 'Prostatic Neoplasms-occur-Prostatic Hyperplasia', 'Arrhythmias, Cardiac-reduce-Death', 'Hypertension-develop-Leukoencephalopathies', 'Prostatic Hyperplasia-predict-Urinary Incontinence', 'Urinary Bladder, Overactive-aging-Prostatic Hyperplasia', 'Urinary Bladder, Overactive-evolve-Prostatic Hyperplasia', 'Hepatitis, Alcoholic-observed-Fibrosis', 'Liver Diseases, Alcoholic-evolve-Liver Cirrhosis, Alcoholic', 'Death-associated-Alcoholism', 'Alcoholism-associated-Death', 'Death-exceed-Liver Failure', 'Liver Cirrhosis, Alcoholic-develop-Carcinoma, Hepatocellular', 'Stomach Diseases-associated-Gastritis, Atrophic', 'Gastritis, Atrophic-associated-Stomach Diseases', 'Obesity-occur-Apnea', 'Hepatomegaly-associated-Stroke', 'Stroke-associated-Hepatomegaly', 'Hepatomegaly-associated-Hypertension', 'Hypertension-associated-Hepatomegaly', 'Hepatomegaly-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-Hepatomegaly', 'Craniofacial Abnormalities-reduced-Alcoholism', 'Death-related-Smoke Inhalation Injury', 'Death-predicted-Smoke Inhalation Injury', 'Acute Disease-lead-Myocardial Infarction', 'Heart Failure-correlated-Obesity', 'Heart Failure-correlated-Infections', 'Death-correlated-Obesity', 'Hypertension-investigate-Kidney Failure, Chronic', 'Hypertension-contribute-Diabetes Mellitus', 'Immunologic Deficiency Syndromes-predisposed-Diabetes Mellitus', 'Death-generate-Heart Diseases', 'Hypoalbuminemia-associated-Anemia', 'Anemia-associated-Hypoalbuminemia', 'Breast Neoplasms-undergo-Neoplasms', 'Parkinson Disease-cause-Hallucinations', 'Werner Syndrome-arise-Abnormalities, Drug-Induced', 'Abdominal Pain-found-Short Bowel Syndrome', 'Carcinoma, Hepatocellular-followed-Neoplasms', 'Death-reduced-Hepatitis B', 'Erectile Dysfunction-correlated-Heart Diseases', 'Erectile Dysfunction-correlated-Hypertension', 'Respiratory Aspiration-require-Pneumonia', 'Inflammatory Bowel Diseases-belong-Fever', 'Inflammatory Bowel Diseases-belong-Diarrhea', 'Chronobiology Disorders-associated-Blindness', 'Blindness-associated-Chronobiology Disorders', 'Osteolysis-recognized-Meningitis, Aseptic', 'Osteolysis-termed-Meningitis, Aseptic', 'Erythema-constitute-Neoplasms', 'Heart Septal Defects, Atrial-increase-Hypotension', 'Heart Septal Defects, Atrial-increase-Ventricular Dysfunction, Left', 'Neoplasms-present-Seizures', 'Abnormalities, Drug-Induced-identified-Epilepsy', 'Joint Diseases-include-Infections', 'Parkinson Disease, Secondary-cause-Parkinson Disease', 'Hypokalemia-associated-Acute Disease', 'Acute Disease-associated-Hypokalemia', 'Carotid Artery Diseases-contribute-Stroke', 'Arrhythmias, Cardiac-contribute-Stroke', 'Spinal Cord Injuries-result-Paraplegia', 'Hypothermia-do-Ventricular Fibrillation', 'Communicable Diseases-improve-Heart Diseases', 'Communicable Diseases-improve-Acquired Immunodeficiency Syndrome', 'Communicable Diseases-improve-Neoplasms', 'Hypoglycemia-precipitate-Myocardial Infarction', 'Diabetes Mellitus-delay-Hypotension', 'Diabetes Mellitus-associated-Diabetes Mellitus, Type 1', 'Diabetes Mellitus, Type 1-associated-Diabetes Mellitus', 'Hypoglycemia-precipitate-Stroke', 'Hypotension-produce-Hypoglycemia', 'Hypotension-delay-Diabetes Mellitus, Type 1', 'Hypotension-associated-Hypoglycemia', 'Hypoglycemia-associated-Hypotension', 'Liver Diseases-make-Hypoglycemia', 'Hodgkin Disease-considered-Neoplasms', 'Dementia-identified-Critical Illness', 'Hemophilia A-listed-Death', 'Hemophilia A-compared-Death', 'Death-listed-HIV Infections', 'Anemia, Hemolytic-raise-Lymphoproliferative Disorders', 'Liver Diseases-include-Hypertension', 'Liver Diseases-include-Heart Failure', 'Pupil Disorders-include-Eye Abnormalities', 'Paralysis-include-Eye Abnormalities', 'Dry Eye Syndromes-include-Eye Abnormalities', 'Corneal Diseases-include-Eye Abnormalities', 'Glaucoma-include-Eye Abnormalities', 'Mastocytosis, Systemic-include-Eye Abnormalities', 'Mesenteric Vascular Occlusion-include-Eye Abnormalities', 'Diabetes Mellitus-include-Eye Abnormalities', 'Optic Neuropathy, Ischemic-include-Eye Abnormalities', 'Infarction-produce-Death', 'Myocardial Infarction-present-Infarction', 'Infarction-considered-Stroke', 'Death-result-Cardiac Complexes, Premature', 'Ventricular Dysfunction-suggest-Heart Valve Diseases', 'Dementia-require-Memory Disorders', 'Heart Arrest-hospitalized-Coronary Artery Disease', 'Coronary Artery Disease-witnessed-Heart Arrest', 'Ulcer-involved-Death', 'Skin Ulcer-experience-Pain', 'Skin Ulcer-experience-Sepsis', 'Hypertension-accompany-Cerebrovascular Disorders', 'Hypertension-accompany-Coronary Artery Disease', 'Hypertension-accompany-Neoplasms', 'Neoplasms-analyzed-Death', 'Cardiomyopathy, Hypertrophic-include-Heart Diseases', 'Pneumonia-monitor-Cardiac Complexes, Premature', 'Breast Neoplasms-carry-Death', 'Nephrotic Syndrome-point-Neoplasms', 'Amyloidosis-point-Neoplasms', 'Amyloidosis-point-Nephrotic Syndrome', 'Death-require-Arrhythmias, Cardiac', 'Death-require-Heart Block', 'Death-require-Heart Arrest', 'Death-succumb-Death, Sudden', 'Disorders of Excessive Somnolence-produce-Psychomotor Disorders', 'Carcinoma, Bronchogenic-evaluate-Death', 'Thyroid Cancer, Papillary-occur-Neoplasms', 'Thrombophilia-predispose-Impotence, Vasculogenic', 'Memory Disorders-found-Dementia', 'Musculoskeletal Diseases-related-Atrophy', 'Coronary Artery Disease-exist-Angina Pectoris', 'Coronary Artery Disease-exist-Myocardial Infarction', 'Seizures-supported-Epilepsy', 'Arrhythmias, Cardiac-prevent-Death', 'Myocardial Infarction-prevent-Death', 'Polycythemia Vera-include-Bone Marrow Diseases', 'Kidney Failure, Chronic-confirm-Drug-Related Side Effects and Adverse Reactions', 'Cataract-detected-Glaucoma, Open-Angle', 'Hypotension-explained-Cardiovascular Diseases', 'Neoplasms-minimize-Postpartum Hemorrhage', 'Intestinal Neoplasms-invade-Neoplasms', 'Fractures, Stress-subjected-Fatigue', 'Fractures, Stress-subjected-Fractures, Bone', 'Pregnancy Complications, Infectious-cause-Heart Failure', 'Death-accounted-Diabetes Mellitus', 'Coronary Artery Disease-produce-Heart Failure, Diastolic', 'Arrhythmias, Cardiac-based-Heart Failure', 'Arrhythmias, Cardiac-made-Heart Failure', 'Hypertension-associated-Ventricular Premature Complexes', 'Ventricular Premature Complexes-associated-Hypertension', 'Hypertension-demonstrate-Hypokalemia', 'Hypertension-demonstrate-Arrhythmias, Cardiac', 'Ventricular Premature Complexes-demonstrate-Hypokalemia', 'Ventricular Premature Complexes-demonstrate-Arrhythmias, Cardiac', 'Urinary Incontinence-combined-Urinary Bladder Diseases', 'Urinary Incontinence-underlie-Urinary Bladder Diseases', 'Cerebrovascular Disorders-represent-Death', 'Bundle-Branch Block-present-Death', 'Malformations of Cortical Development-occur-Alzheimer Disease', 'Arrhythmias, Cardiac-analyzed-Tachycardia, Sinus', 'Arrhythmias, Cardiac-include-Tachycardia, Sinus', 'Arrhythmias, Cardiac-analyzed-Tachycardia, Supraventricular', 'Arrhythmias, Cardiac-analyzed-Tachycardia, Ventricular', 'Arrhythmias, Cardiac-include-Tachycardia, Ventricular', 'Arrhythmias, Cardiac-analyzed-Atrial Flutter', 'Arrhythmias, Cardiac-include-Ventricular Fibrillation', 'Arrhythmias, Cardiac-analyzed-Ventricular Fibrillation', 'Tachycardia, Ventricular-misdiagnosed-Tachycardia, Supraventricular', 'Sclerosis-associated-Hypertension', 'Hypertension-associated-Sclerosis', 'Heart Failure-present-Myocardial Infarction', 'Hypertension-prevent-Stroke', 'Hypertension-reduce-Coronary Artery Disease', 'Infections-living-Chemical and Drug Induced Liver Injury', 'Cerebral Amyloid Angiopathy-observed-Neurodegenerative Diseases', 'Cerebral Amyloid Angiopathy-receive-Gerstmann-Straussler-Scheinker Disease', 'Sclerosis-meet-Alzheimer Disease', 'Alzheimer Disease-detected-Dementia', 'Alzheimer Disease-include-Sclerosis', 'Alzheimer Disease-accompanied-Sclerosis', 'Cerebral Infarction-include-Alzheimer Disease', 'Alzheimer Disease-include-Leukoencephalopathies', 'Alzheimer Disease-accompanied-Leukoencephalopathies', 'Dementia-accompanied-Sclerosis', 'Dementia-contribute-Cerebral Infarction', 'Dementia-contribute-Leukoencephalopathies', 'Sclerosis-accompanied-Cerebral Infarction', 'Sclerosis-accompanied-Leukoencephalopathies', 'Apnea-diagnose-Sleep Apnea, Obstructive', 'Sleep Apnea Syndromes-diagnose-Sleep Apnea, Obstructive', 'Sleep Apnea, Obstructive-include-Sleep Wake Disorders', 'Sleep Apnea, Obstructive-include-Headache', 'Death-suggest-Sleep Apnea, Obstructive', 'Immunologic Deficiency Syndromes-suggested-Sleep Apnea, Obstructive', 'Immunologic Deficiency Syndromes-exacerbate-Sleep Apnea, Obstructive', 'Tricuspid Valve Insufficiency-include-Death', 'Tricuspid Valve Insufficiency-show-Death', 'Drug Hypersensitivity-described-Pain', 'Hyperglycemia-played-Retinal Diseases', 'Muscle Weakness-suffer-Adrenal Insufficiency', 'Adrenal Insufficiency-caused-Mastocytosis, Systemic', 'Prostatitis-evaluated-Prostatic Hyperplasia', 'Death-bias-Neoplasms', 'Osteoporosis-induced-Neurologic Manifestations', 'Bone Neoplasms-induced-Neurologic Manifestations', 'Drug-Related Side Effects and Adverse Reactions-cause-Delirium', 'Urinary Bladder, Underactive-present-Urinary Incontinence', 'Death-compare-Tuberculosis', 'Fever-associate-Pneumonia', 'Pneumonia-associate-Fever', 'Cough-associate-Pneumonia', 'Pneumonia-associate-Cough', 'Leukocytosis-associate-Pneumonia', 'Pneumonia-associate-Leukocytosis', 'Bacteremia-precede-Infections', 'Hyponatremia-find-Tuberculoma', 'Death-related-Ulcer', 'Death-indicate-Acute Kidney Injury', 'Carcinoma, Hepatocellular-diagnosed-Neoplasms', 'Atrophy-determined-Brain Diseases, Metabolic', 'Death-expressed-Motor Neuron Disease', 'Motor Neuron Disease-decrease-Death', 'Constipation-differ-Chronic Disease', 'Stroke-induce-Headache Disorders, Secondary', 'Death-related-Dysentery', 'Dehydration-result-Gastrointestinal Diseases', 'Atherosclerosis-predispose-Dehydration', 'Atherosclerosis-predispose-Diarrhea', 'Diarrhea-result-Dehydration', 'Kidney Neoplasms-increase-Cataract', 'Metabolic Diseases-occur-Nerve Degeneration', 'Neurologic Manifestations-lead-Hyperplasia', 'Parkinson Disease, Secondary-identify-Alzheimer Disease', 'Parkinsonian Disorders-accounted-Parkinson Disease, Secondary', 'Parkinson Disease-accounted-Parkinson Disease, Secondary', 'Angiodysplasia-account-Hemorrhage', 'Angiodysplasia-occur-Renal Insufficiency', 'Angiodysplasia-occur-von Willebrand Diseases', 'Angiodysplasia-occur-Aortic Valve Stenosis', 'Angiodysplasia-occur-Fibrosis', 'Angiodysplasia-occur-Lung Diseases', 'Myocardial Infarction-reduced-Death', 'Coronary Artery Disease-reduced-Death', 'Death-attributed-Cold Injury', 'Tachycardia-report-Syncope', 'Tachycardia, Supraventricular-terminate-Atrial Fibrillation', 'Tachycardia, Supraventricular-reduce-Myocardial Infarction', 'Sleep Initiation and Maintenance Disorders-precipitate-Glaucoma, Angle-Closure', 'Xerostomia-reduce-Mucositis', 'Mucositis-increase-Respiratory Tract Infections', 'Heart Failure-produced-Cardiovascular Abnormalities', 'Ischemia-associated-Alzheimer Disease', 'Alzheimer Disease-associated-Ischemia', 'Pain-related-Ulcer', 'Pancreatic Neoplasms-present-Pancreatitis', 'Pancreatic Neoplasms-included-Pancreatitis', 'Heart Arrest-exceed-Syncope', 'Adenocarcinoma-develop-Colitis, Ulcerative', 'Death-reflect-Wounds and Injuries', 'Death-assessed-Appendicitis', 'Death-prevent-Appendicitis', 'Respiratory Distress Syndrome-include-Ischemia', 'Hypotension-include-Ischemia', 'Oliguria-include-Ischemia', 'Sepsis-include-Ischemia', 'Coronary Artery Disease-consider-Hypothyroidism', 'Sepsis-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-Sepsis', 'Coronary Artery Disease-focus-Brain Infarction', 'Death-describe-Stroke', 'Neuroaxonal Dystrophies-contain-Diabetes Mellitus', 'Death-attributed-Multiple Organ Failure', 'Ascites-represent-Peritonitis, Tuberculous', 'Xerostomia-taken-Cardiovascular Abnormalities', 'Xerostomia-taken-Gingival Overgrowth', 'Xerostomia-taken-Movement Disorders', 'Hypogonadism-found-Crush Injuries', 'Hypogonadism-found-Immunologic Deficiency Syndromes', 'Osteoporosis-concerned-Osteoporotic Fractures', 'Pain-assessed-Heredodegenerative Disorders, Nervous System', 'Constipation-seen-Hirschsprung Disease', 'Constipation-affected-Colonic Neoplasms', 'Constipation-found-Irritable Bowel Syndrome', 'Diabetes Mellitus, Type 2-correlated-Learning Disabilities', 'Seizures-confused-Nervous System Diseases', 'Kidney Diseases-present-Acute Kidney Injury', 'Colonic Neoplasms-cause-Dehydration', 'Cerebral Infarction-attribute-Death', 'Cerebral Infarction-attribute-Ischemia', 'Death-attribute-Ischemia', 'Pain-attributed-Respiratory Insufficiency', 'Movement Disorders-arise-Seizures', 'Headache Disorders, Secondary-evaluated-Gallstones', 'Anemia, Sickle Cell-increase-Necrosis', 'Primary Ovarian Insufficiency-caused-Autoimmune Diseases', 'Aortic Aneurysm, Abdominal-associated-Aneurysm', 'Aneurysm-associated-Aortic Aneurysm, Abdominal', 'Cardiomegaly-associated-Hypertension', 'Hypertension-associated-Cardiomegaly', 'Coma-include-Death', 'Ventricular Fibrillation-include-Death', 'Death-follow-Craniocerebral Trauma', 'Death-met-Brain Death', 'Drug-Related Side Effects and Adverse Reactions-include-Cheilitis', 'Drug-Related Side Effects and Adverse Reactions-include-Dermatitis', 'Drug-Related Side Effects and Adverse Reactions-include-Gastrointestinal Diseases', 'Drug-Related Side Effects and Adverse Reactions-include-Pain', 'Drug-Related Side Effects and Adverse Reactions-include-Chemical and Drug Induced Liver Injury', 'Death-survive-Infections', 'Osteoporosis-result-Osteoporotic Fractures', 'Virilism-lead-Asthenia', 'Virilism-lead-Osteoporosis', 'Adenocarcinoma-followed-Carcinoma, Squamous Cell', 'Chronic Disease-continue-Respiratory Distress Syndrome', 'Adenocarcinoma-remain-Carcinoma, Squamous Cell', 'Alzheimer Disease-prevent-Dental Caries', 'Cardiovascular Diseases-increase-Stroke', 'Stroke-include-Heart Diseases', 'Hypertension-credited-Death', 'Hypertension-accelerate-Death', 'Dementia-conceptualize-Chronic Disease', 'Brain Injuries-resemble-Alzheimer Disease', 'Bone Neoplasms-determine-Bone Diseases, Metabolic', 'Aneurysm-accelerate-Hypertension', 'Atherosclerosis-accelerate-Hypertension', 'Cerebral Hemorrhage-constitute-Stroke', 'Nerve Degeneration-cause-Movement Disorders', 'Goiter-excluded-Heart Diseases', 'Prostatic Hyperplasia-seen-Adenomatous Polyposis Coli', 'Language Disorders-caused-Stroke', 'Language Disorders-caused-Craniocerebral Trauma', 'Stroke-caused-Craniocerebral Trauma', 'Language Disorders-experienced-Stroke', 'Death-outcome-Stroke', 'Eczema-increase-Headache Disorders, Secondary', 'Death-caused-Asphyxia', 'Prostatic Neoplasms-increasing-Neoplasms', 'Peripheral Arterial Disease-affect-Death', 'Neuroendocrine Tumors-described-Lung Diseases', 'Subarachnoid Hemorrhage-attributed-Cerebral Amyloid Angiopathy', 'Subarachnoid Hemorrhage-accompany-Cerebral Hemorrhage', 'Death-occur-Lung Diseases', 'Sarcopenia-prevent-Diabetes Mellitus, Type 2', 'Sarcopenia-prevent-Coronary Artery Disease', 'Sarcopenia-prevent-Hypertension', 'Sarcopenia-prevent-Osteoporosis', 'Sarcopenia-exert-Obesity', 'Epilepsy-manifested-Seizures', 'Epilepsy-contribute-Seizures', 'Hyperlipoproteinemia Type II-participate-Atherosclerosis', 'Hyperlipoproteinemia Type II-evaluate-Arcus Senilis', 'Hyperlipoproteinemia Type II-evaluate-Atherosclerosis', 'Diabetes Mellitus-admitted-Kidney Failure, Chronic', 'Diabetes Mellitus-admitted-Coronary Artery Disease', 'Hearing Loss-considered-Psychoses, Substance-Induced', 'Acute Kidney Injury-present-Infections', 'Pyelonephritis-present-Infections', 'Kidney Diseases-related-Hypertension', 'Hypertension-related-Kidney Diseases', 'Leukemia, Myeloid, Acute-suffer-Bone Marrow Failure Disorders', 'Meningitis, Bacterial-considered-Acute Kidney Injury', 'Hematuria-occur-Cystitis', 'Migraine Disorders-evolve-Headache', 'Hepatitis, Viral, Human-complicated-Liver Failure', 'Death-appear-Pancreatic Diseases', 'Cardiovascular Diseases-increased-Hypertension', 'Myocardial Infarction-carry-Death', 'Myocardial Infarction-accompany-Shock, Cardiogenic', 'Death-accompany-Shock, Cardiogenic', 'Gait Disorders, Neurologic-caused-Nervous System Diseases', 'Communicable Diseases-expected-Acquired Immunodeficiency Syndrome', 'Infections-expected-Acquired Immunodeficiency Syndrome', 'Pneumonia-expected-Acquired Immunodeficiency Syndrome', 'Neurodegenerative Diseases-associated-Peripheral Vascular Diseases', 'Peripheral Vascular Diseases-associated-Neurodegenerative Diseases', 'Obesity-associated-Peripheral Vascular Diseases', 'Peripheral Vascular Diseases-associated-Obesity', 'Diabetes Mellitus-seen-Peripheral Vascular Diseases', 'Hypertension-seen-Peripheral Vascular Diseases', 'Death-seen-Peripheral Vascular Diseases', 'Atrioventricular Block-include-Coronary Artery Disease', 'Seizures-related-Intellectual Disability', 'Seizures-identify-Intellectual Disability', 'Seizures-work-Intellectual Disability', 'Obesity-work-Intellectual Disability', 'Cardiovascular Diseases-work-Intellectual Disability', 'Death-establish-Obesity', 'Postpartum Hemorrhage-found-Obesity', 'Fibrosis-came-Ascites', 'Hypertension-assessed-Aneurysm', 'Angina Pectoris-include-Aneurysm', 'Death-do-Stroke', 'Coronary Artery Disease-do-Stroke', 'Liver Diseases-fall-Myocardial Infarction', 'Dyspnea-beat-Erectile Dysfunction', 'Dyspnea-beat-Diabetes Mellitus', 'Dyspnea-beat-Alcoholism', 'Cardiovascular Diseases-indicate-Nervous System Diseases', 'Erectile Dysfunction-indicate-Nervous System Diseases', 'Hearing Loss-manifest-Deafness', 'Gallstones-include-Obesity', 'Gallstones-include-Diabetes Mellitus', 'Drug-Related Side Effects and Adverse Reactions-altered-Hearing Disorders', 'Neoplasms-become-Drug-Related Side Effects and Adverse Reactions', 'Neoplasms-modified-Pain', 'Drug-Related Side Effects and Adverse Reactions-modified-Pain', 'Tuberculosis-considered-Respiratory Tract Infections', 'Amnesia-result-Alcoholic Korsakoff Syndrome', 'Hypertension-correlated-Carotid Stenosis', 'Neurologic Manifestations-improve-Cleft Palate', 'Diabetes Mellitus-compare-Huntington Disease', 'Hydrocephalus-associated-Dementia', 'Dementia-associated-Hydrocephalus', 'Hydrocephalus-associated-Urinary Incontinence', 'Urinary Incontinence-associated-Hydrocephalus', 'Hydrocephalus-associated-Gait Apraxia', 'Gait Apraxia-associated-Hydrocephalus', 'Mucopolysaccharidosis I-develop-Intestinal Polyposis', 'Cardiomyopathies-occur-Death', 'Death-associated-Ovarian Diseases', 'Ovarian Diseases-associated-Death', 'Death-originate-Bacteremia', 'Death-reduce-Bacteremia', 'Death-suspected-Ulcer', 'Melanoma-evolve-Neoplasms', 'Cystic Fibrosis-characterized-Infections', 'Cystic Fibrosis-characterized-Malabsorption Syndromes', 'Cystic Fibrosis-characterized-Exocrine Pancreatic Insufficiency', 'Cystic Fibrosis-increase-Infections', 'Genetic Diseases, Inborn-characterized-Infections', 'Genetic Diseases, Inborn-characterized-Malabsorption Syndromes', 'Genetic Diseases, Inborn-characterized-Exocrine Pancreatic Insufficiency', 'Malabsorption Syndromes-caused-Exocrine Pancreatic Insufficiency', 'Dyspnea-develop-Endocarditis, Bacterial', 'Brain Diseases-distinguish-Delirium', 'Wounds and Injuries-implicated-Nervous System Diseases', 'Wounds and Injuries-implicated-Amyotrophic Lateral Sclerosis', 'Amyotrophic Lateral Sclerosis-relate-Wounds and Injuries', 'Amyotrophic Lateral Sclerosis-precede-Wounds and Injuries', 'Amyotrophic Lateral Sclerosis-develop-Wounds and Injuries', 'Infarction, Middle Cerebral Artery-investigated-Cerebral Infarction', 'Diabetes Mellitus-ascertained-Death', 'Diabetes Mellitus, Type 1-ascertained-Death', 'Hypertension-explained-Obesity', 'Hypertension-explained-Diabetes Mellitus', 'Pulmonary Edema-presented-Infections', 'Pulmonary Edema-presented-Bacteremia', 'Esophageal Achalasia-associated-Lung Diseases', 'Lung Diseases-associated-Esophageal Achalasia', 'Esophageal Achalasia-associated-Malnutrition', 'Malnutrition-associated-Esophageal Achalasia', 'Esophageal Achalasia-associated-Neoplasms', 'Neoplasms-associated-Esophageal Achalasia', 'Ovarian Neoplasms-co-sponsored-Neoplasms', 'Malnutrition-coupled-Adrenal Insufficiency', 'Nephrosis-diagnosed-Amyloidosis', 'Nephrosis-diagnosed-Diabetes Mellitus', 'Alzheimer Disease-obtained-Nervous System Diseases', 'Weight Loss-related-Neoplasms', 'Parkinson Disease-obtained-Nervous System Diseases', 'Huntington Disease-obtained-Nervous System Diseases', 'Histiocytoma, Malignant Fibrous-involve-Muscular Dystrophies, Limb-Girdle', 'Neoplasms-involve-Muscular Dystrophies, Limb-Girdle', 'Liver Cirrhosis, Biliary-develop-Gallstones', 'Brugada Syndrome-query-Hypothyroidism', 'Atrial Fibrillation-query-Hypothyroidism', 'Liver Cirrhosis, Biliary-lead-Hepatic Insufficiency', 'Liver Cirrhosis, Biliary-lead-Hypertension', 'Liver Cirrhosis, Biliary-lead-Hypersplenism', 'Liver Cirrhosis, Biliary-lead-Pancytopenia', 'Liver Cirrhosis, Biliary-lead-Ascites', 'Liver Cirrhosis, Biliary-lead-Brain Diseases', 'Cerebral Amyloid Angiopathy-reveal-Intracranial Hemorrhages', 'Intracranial Hemorrhage, Hypertensive-coexist-Alzheimer Disease', 'Tuberculosis, Pleural-considered-Acquired Immunodeficiency Syndrome', 'Ulcer-caused-Embolism, Cholesterol', 'Embolism, Cholesterol-considered-Postpartum Hemorrhage', 'Hyperinsulinism-related-Coronary Artery Disease', 'Aneurysm-conducted-Death', 'Diabetes Mellitus-experience-Vitreous Hemorrhage', 'Diabetes Mellitus-experience-Vitreous Detachment', 'Hyperglycemia-alter-Vitreous Hemorrhage', 'Hypotension-serve-Constriction, Pathologic', 'Atrial Fibrillation-serve-Constriction, Pathologic', 'Stroke-serve-Constriction, Pathologic', 'Headache Disorders, Secondary-identified-Chronic Disease', 'Myocardial Infarction-identified-Chronic Disease', 'Neurologic Manifestations-ensure-Fragile X Syndrome', 'Immunologic Deficiency Syndromes-play-Anemia', 'Hernia-provide-Pain, Postoperative', 'Malaria-referred-Fever', 'Fibrosis-observed-Muscular Dystrophy, Duchenne', 'Fibrosis-observed-Muscular Dystrophies, Limb-Girdle', 'Fibrosis-observed-Walker-Warburg Syndrome', 'Fibrosis-observed-Myotonic Dystrophy', 'Myotonic Dystrophy-involved-Arrhythmias, Cardiac', 'Myotonic Dystrophy-result-Arrhythmias, Cardiac', 'Alzheimer Disease-observed-Walker-Warburg Syndrome', 'Alzheimer Disease-observed-Myotonic Dystrophy', 'Alzheimer Disease-observed-Muscular Dystrophies', 'Cardiomyopathies-seem-Muscular Dystrophies', 'Osteoarthritis-show-Diabetes Mellitus', 'Atherosclerosis-suspected-Fibrosis', 'Eosinophilia-point-Drug Hypersensitivity', 'Eosinophilia-point-Fibrosis', 'Drug Hypersensitivity-point-Fibrosis', 'Coronary Artery Disease-coexist-Hypertension', 'Hypertension-include-Glucose Metabolism Disorders', 'Cardiomyopathy, Hypertrophic-coexist-Hypertension', 'Heart Failure, Diastolic-coexist-Hypertension', 'Hyperlipidemias-search-Atherosclerosis', 'Hypertriglyceridemia-evaluate-Atherosclerosis', 'Heart Failure, Systolic-shown-Heart Failure', 'Pain-induce-Drug Hypersensitivity', 'Pain-induce-Keratitis', 'Pain-induce-Pigmentation Disorders', 'Drug Hypersensitivity-induce-Pigmentation Disorders', 'Keratitis-induce-Pigmentation Disorders', 'Cardiovascular Diseases-become-Hypertension', 'Leukemia, Lymphocytic, Chronic, B-Cell-undergo-Death', 'Leukemia, Lymphocytic, Chronic, B-Cell-undergo-Surgical Wound Infection', 'Prostatic Hyperplasia-minimise-Hypotension', 'Prostatic Hyperplasia-minimise-Syncope', 'Urinary Bladder Diseases-associated-Prostatic Hyperplasia', 'Prostatic Hyperplasia-associated-Urinary Bladder Diseases', 'Leukemia-ameliorate-Leukemia, Myeloid, Acute', 'Pregnancy, Prolonged-ameliorate-Leukemia, Myeloid, Acute', 'Leukemia-withstand-Bone Marrow Diseases', 'Leukemia-withstand-Drug-Related Side Effects and Adverse Reactions', 'Bone Marrow Diseases-withstand-Drug-Related Side Effects and Adverse Reactions', 'Vision Disorders-prevent-Cataract', 'Vision Disorders-prevent-Glaucoma', 'Vision Disorders-prevent-Diabetes Mellitus', 'Xerophthalmia-cause-Vision Disorders', 'Xerophthalmia-cause-Death', 'Immunologic Deficiency Syndromes-cause-Vision Disorders', 'Prostatic Neoplasms-evaluated-Urinary Bladder Neck Obstruction', 'Blindness-result-Trachoma', 'Blindness-result-Infections', 'Arthritis, Psoriatic-alleviate-Pain', 'Arthritis, Rheumatoid-include-Joint Diseases', 'Gout-include-Joint Diseases', 'Rheumatic Diseases-include-Joint Diseases', 'Nephritis, Interstitial-include-Kidney Diseases', 'Acquired Immunodeficiency Syndrome-display-Multiple Sclerosis', 'Movement Disorders-trained-Dyskinesia, Drug-Induced', 'Syncope, Vasovagal-recorded-Arrhythmias, Cardiac', 'Hyperostosis, Diffuse Idiopathic Skeletal-associated-Osteoarthritis', 'Osteoarthritis-associated-Hyperostosis, Diffuse Idiopathic Skeletal', 'Hyperostosis, Diffuse Idiopathic Skeletal-lead-Calcinosis', 'Sarcoidosis-result-Bone Neoplasms', 'Gliosis-encompass-Hyperplasia', 'Gliosis-encompass-Hypertrophy', 'Neurodegenerative Diseases-encompass-Hyperplasia', 'Pain-considered-Signs and Symptoms, Digestive', 'Retinal Diseases-include-Communicable Diseases', 'Atherosclerosis-include-Communicable Diseases', 'Kidney Diseases-include-Communicable Diseases', 'Nervous System Diseases-include-Communicable Diseases', 'Hearing Loss-included-Parkinson Disease', 'Hearing Loss-included-Stroke', 'Chronic Disease-associated-Cardiac Output, Low', 'Cardiac Output, Low-associated-Chronic Disease', 'Calcinosis-detected-Huntington Disease', 'Calcinosis-detected-Kidney Failure, Chronic', 'Glaucoma-diminished-Nerve Degeneration', 'Neuroblastoma-lead-Metabolic Diseases', 'Parkinson Disease-include-Wounds and Injuries', 'Osteoporotic Fractures-present-Osteoporosis', 'Heredodegenerative Disorders, Nervous System-make-Dementia', 'Hypernatremia-reflect-Nervous System Diseases', 'Nerve Degeneration-stopped-Seizures', 'Seizures-stopped-Status Epilepticus', 'Kidney Diseases-diagnosed-Glomerulonephritis', 'Glomerulonephritis-seem-Ischemia', 'Protein-Energy Malnutrition-prolong-Neoplasms', 'Pain-look-Wounds and Injuries', 'Mitochondrial Diseases-reported-Myotonic Dystrophy', 'Heart Diseases-reduce-Bone Neoplasms', 'Endometrial Neoplasms-consider-Carcinogenesis', 'Hypoxia-stimulate-Hyperplasia', 'Obesity-recognized-Endometrial Neoplasms', 'Hypertension-recognized-Endometrial Neoplasms', 'Diabetes Mellitus-recognized-Endometrial Neoplasms', 'Death-increase-Fatigue', 'Hypoxia-lead-Hyperplasia', 'Endometrial Neoplasms-lead-Hyperplasia', 'Fatigue-contribute-Fractures, Bone', 'Osteoporosis-influence-Wounds and Injuries', 'Bone Neoplasms-slow-Fractures, Bone', 'Immunologic Deficiency Syndromes-slow-Bone Neoplasms', 'Neoplasms-lead-Inflammation', 'Neoplasms-lead-Atherosclerosis', 'Aneurysm-associate-Psychoses, Substance-Induced', 'Psychoses, Substance-Induced-associate-Aneurysm', 'Alzheimer Disease-cause-Liver Neoplasms', 'Alzheimer Disease-cause-Parkinson Disease', 'Death-approach-Heart Failure', 'Cardiomyopathy, Dilated-maintain-Stroke', 'Hyperglycemia-induce-Hypothalamic Neoplasms', 'Osteoarthritis-found-Hip Fractures', 'Osteoarthritis-found-Osteoporosis', 'Nerve Degeneration-remain-Dyskinesia, Drug-Induced', 'Periodontal Diseases-compared-Periodontitis', 'Periodontal Diseases-affected-Periodontitis', 'Hypertension-observed-Hyperplasia', 'Hypertrophy-associated-Hyperplasia', 'Hyperplasia-associated-Hypertrophy', 'Erythema-occur-Pruritus', 'Airway Obstruction-lead-Urinary Incontinence', 'Stroke-control-Diabetes Mellitus', 'Stroke-control-Angina Pectoris', 'Meningeal Neoplasms-grow-Neoplasms', 'Musculoskeletal Diseases-represented-Joint Diseases', 'Emphysema-lead-Death', 'Lymphangiectasis, Intestinal-lead-Death', 'Alzheimer Disease-present-Blindness', 'Diabetes Mellitus-lead-Learning Disabilities', 'Hypokalemia-induce-Arrhythmias, Cardiac', 'Hypertension-use-Coronary Artery Disease', 'Hypertension-use-Stroke', 'Stroke-concentrated-Cardiovascular Diseases', 'Stroke-concentrated-Diabetes Mellitus', 'Stroke-concentrated-Atrial Fibrillation', 'Stroke-concentrated-Hypertrophy, Left Ventricular', 'Bone Diseases, Metabolic-occur-Osteomalacia', 'Bone Diseases, Metabolic-occur-Osteoporosis', 'Leukemia, Erythroblastic, Acute-include-Leukemia, Myeloid, Acute', 'Aneurysm-associated-Aortic Diseases', 'Aortic Diseases-associated-Aneurysm', 'Leukemia, Erythroblastic, Acute-viewed-Leukemia, Myeloid, Acute', 'Myocardial Infarction-undergo-Infarction', 'Myocardial Infarction-undergo-Ventricular Septal Rupture', 'Infarction-undergo-Ventricular Septal Rupture', 'Hypertrophy-predict-Brain Infarction', 'Hypertrophy-predict-Heart Failure', 'Glaucoma-associate-Deaf-Blind Disorders', 'Deaf-Blind Disorders-associate-Glaucoma', 'Diabetes Mellitus-associate-Deaf-Blind Disorders', 'Deaf-Blind Disorders-associate-Diabetes Mellitus', 'Cataract-associate-Deaf-Blind Disorders', 'Deaf-Blind Disorders-associate-Cataract', 'Gastritis-suggest-Infections', 'Atrophy-associated-Gastritis', 'Gastritis-associated-Atrophy', 'Insulinoma-associated-Diabetes Mellitus, Type 2', 'Diabetes Mellitus, Type 2-associated-Insulinoma', 'Renal Colic-leak-Aortic Aneurysm, Abdominal', 'Cardiovascular Diseases-accompany-Hypertension', 'Gangrene-require-Arterial Occlusive Diseases', 'Movement Disorders-accompanied-Ocular Motility Disorders', 'Cardiovascular Diseases-include-Thrombosis', 'Thrombosis-involved-Atherosclerosis', 'Atherosclerosis-characterized-Lipid Metabolism Disorders', 'Osteoporosis-progress-Atherosclerosis', 'Atherosclerosis-develop-Osteoporosis', 'Hyperemia-peak-Heart Arrest', 'Hyperemia-peak-Ischemia', 'Atherosclerosis-relate-Carotid Artery Diseases', 'Dyspepsia-associated-Gastroesophageal Reflux', 'Gastroesophageal Reflux-associated-Dyspepsia', 'Vomiting-associated-Gastroesophageal Reflux', 'Gastroesophageal Reflux-associated-Vomiting', 'Deglutition Disorders-associated-Gastroesophageal Reflux', 'Gastroesophageal Reflux-associated-Deglutition Disorders', 'Cough-associated-Gastroesophageal Reflux', 'Gastroesophageal Reflux-associated-Cough', 'Nocturia-reported-Fractures, Bone', 'Tachycardia-tend-Cardiac Output, High', 'Cardiac Output, High-decrease-Stroke', 'Fractures, Bone-accompanied-Wounds and Injuries', 'Wounds and Injuries-considered-Fractures, Bone', 'Fractures, Bone-caused-Synovitis', 'Epilepsy, Temporal Lobe-distinguish-Alzheimer Disease', 'Nerve Degeneration-observe-Alzheimer Disease', 'Heart Failure-associate-Death', 'Death-associate-Heart Failure', 'Myocardial Infarction-associate-Death', 'Death-associate-Myocardial Infarction', 'Hip Fractures-represent-Osteoporosis', 'Appendicitis-identified-Communicable Diseases', 'Drug-Related Side Effects and Adverse Reactions-result-Leukemia, Myeloid, Acute', 'Fever-focus-Infections', 'Fever-focus-Endocarditis, Bacterial', 'Fever-focus-Tuberculosis', 'Fever-focus-Rheumatic Diseases', 'Fever-focus-Arteritis', 'Fever-focus-Polyarteritis Nodosa', 'Fever-focus-Neoplasms', 'Fever-focus-Lymphoma', 'Fever-focus-Nephroma, Mesoblastic', 'Neuroma, Acoustic-achieved-Neoplasms', 'Hyperglycemia-induced-Diabetes Mellitus', 'Coronary Artery Disease-appear-Peripheral Vascular Diseases', 'Atherosclerosis-precede-Peripheral Vascular Diseases', 'Diabetes Mellitus-include-Bone Diseases, Metabolic', 'HIV Infections-remain-Acquired Immunodeficiency Syndrome', 'Colitis-range-Diarrhea', 'Diarrhea-range-Sepsis', 'Colitis-carry-Death', 'Leukemia, Lymphocytic, Chronic, B-Cell-transferred-Immunologic Deficiency Syndromes', 'Urinary Incontinence-caused-Neurologic Manifestations', 'Urinary Incontinence-caused-Diabetes Mellitus', 'Urinary Incontinence-caused-Airway Obstruction', 'Urinary Incontinence-caused-Prostatitis', 'Urinary Incontinence-caused-Neoplasms', 'Asthma-include-Respiratory Tract Diseases', 'Lung Neoplasms-include-Respiratory Tract Diseases', 'Urinary Incontinence-directed-Infections', 'Urinary Incontinence-directed-Atrophic Vaginitis', 'Stomach Neoplasms-composed-Neoplasms', 'Neoplasms-studied-Stomach Neoplasms', 'Pneumonia-lead-Tachycardia', 'Plaque, Amyloid-appear-Alzheimer Disease', 'Alzheimer Disease-increase-Cerebrovascular Disorders', 'Hyperinsulinism-contribute-Cardiovascular Diseases', 'Plaque, Amyloid-observed-Nerve Degeneration', 'Hypothalamic Neoplasms-help-Alzheimer Disease', 'Hypertension-identified-Ocular Hypertension', 'Diabetes Mellitus-identified-Ocular Hypertension', 'Obesity-associated-Hypothyroidism', 'Hypothyroidism-associated-Obesity', 'Hypertension-find-Stroke', 'Stroke-reduce-Myocardial Infarction', 'Muscular Diseases-encompass-Neurodegenerative Diseases', 'Adrenal Insufficiency-accelerate-Bone Neoplasms', 'Endocrine System Diseases-associate-Pheochromocytoma', 'Pheochromocytoma-associate-Endocrine System Diseases', 'Wounds and Injuries-cause-Fractures, Bone', 'Drug-Related Side Effects and Adverse Reactions-include-Hemorrhage', 'Drug-Related Side Effects and Adverse Reactions-include-Heart Diseases', 'Extranodal Extension-combine-Hydrocephalus', 'Disorders of Excessive Somnolence-associated-Sleep Initiation and Maintenance Disorders', 'Sleep Initiation and Maintenance Disorders-associated-Disorders of Excessive Somnolence', 'Rhabdomyolysis-associated-Communicable Diseases', 'Communicable Diseases-associated-Rhabdomyolysis', 'Rhabdomyolysis-associated-Stroke', 'Stroke-associated-Rhabdomyolysis', 'Rhabdomyolysis-associated-Hyponatremia', 'Hyponatremia-associated-Rhabdomyolysis', 'Rhabdomyolysis-associated-Hypernatremia', 'Hypernatremia-associated-Rhabdomyolysis', 'Rhabdomyolysis-associated-Hypothermia', 'Hypothermia-associated-Rhabdomyolysis', 'Spinal Cord Injuries-associated-Pain', 'Pain-associated-Spinal Cord Injuries', 'Venous Thrombosis-prevent-Pulmonary Embolism', 'Spinal Cord Injuries-represent-Pain', "Sjogren's Syndrome-exist-Autoimmune Diseases", "Sjogren's Syndrome-exist-Arthritis, Rheumatoid", "Sjogren's Syndrome-exist-Lupus Erythematosus, Systemic", "Sjogren's Syndrome-exist-Scleroderma, Systemic", 'Autoimmune Diseases-lead-Xerostomia', 'Hemorrhage-warrant-Colonic Neoplasms', 'Neoplasms-referred-Hemorrhage', 'Adenoma-referred-Hemorrhage', 'Stroke-anticipated-Death', 'Hypertension-prevent-Obesity', 'Hypertension-receive-Seizures', 'Dementia-surveyed-Seizures', 'Pruritus-occur-Nausea', 'Pruritus-occur-Vomiting', 'Alzheimer Disease-share-Abnormalities, Drug-Induced', 'Alzheimer Disease-overwhelm-Nerve Degeneration', 'Hypoxia-induce-Fatigue', 'Hypertrophy-diagnosed-Hypertension', 'Hypertrophy-diagnosed-Neurologic Manifestations', 'Hypertension-diagnosed-Neurologic Manifestations', 'Atherosclerosis-define-Calcinosis', 'Atherosclerosis-define-Aneurysm', 'Neoplasms-include-Keratosis', "Neoplasms-include-Bowen's Disease", 'Neoplasms-include-Carcinoma, Basal Cell', 'Neoplasms-include-Carcinoma, Squamous Cell', 'Neoplasms-include-Melanoma', 'Hypothyroidism-suggest-Edema', 'Autoimmune Diseases-base-Neoplasms', 'Brain Damage, Chronic-correspond-Seizures', 'Status Epilepticus-assumed-Seizures', 'Myocardial Infarction-result-Neoplasms', 'Pain-report-Constipation', 'Hemorrhoids-report-Constipation', 'Heart Failure, Diastolic-isolate-Death', 'Death-reach-Renal Insufficiency', 'Polycystic Kidney Diseases-result-Renal Insufficiency', 'Dementia-include-Neurosyphilis', 'Hypertension-lead-Kidney Failure, Chronic', 'Nephrosclerosis-correlated-Hypertension', 'Angina, Unstable-associated-Death', 'Death-associated-Angina, Unstable', 'Angina, Unstable-suffer-Myocardial Infarction', 'Fibrosis-minimized-Blood Loss, Surgical', 'Hypertension-report-Stroke', 'Hypertension-report-Myocardial Infarction', 'Myocardial Infarction-treated-Hypertension', 'Nocturnal Paroxysmal Dystonia-associated-Epilepsy', 'Epilepsy-associated-Nocturnal Paroxysmal Dystonia', 'Coronary Artery Disease-performed-Motion Sickness', 'Xerostomia-include-Pain', 'Constipation-include-Pain', 'Motion Sickness-develop-Atrioventricular Block', 'Atrophy-seem-Basal Ganglia Diseases', 'Wounds and Injuries-experience-Obesity', 'Infections-present-Anorexia', 'Infections-present-Muscle Weakness', 'Bacteremia-include-Infections', 'Pressure Ulcer-include-Infections', 'Dementia-compared-Dementia, Vascular', 'Hypertension-associate-Dementia, Vascular', 'Dementia, Vascular-associate-Hypertension', 'Hypercholesterolemia-seen-Hyperlipoproteinemia Type II', 'Death-seen-Hyperlipoproteinemia Type II', 'Hypertension-related-Carotid Artery Diseases', 'Hypotension, Orthostatic-associated-Ischemia', 'Ischemia-associated-Hypotension, Orthostatic', 'Cardiovascular Diseases-assess-Hypotension, Orthostatic', 'Hypotension, Orthostatic-associated-Carotid Stenosis', 'Carotid Stenosis-associated-Hypotension, Orthostatic', 'Atrophy-characterized-Cardiomyopathy, Dilated', 'Cardiomyopathy, Dilated-characterized-Cerebellar Diseases', 'Urinary Incontinence-precipitated-Delirium', 'Urinary Incontinence-precipitated-Infections', 'Postoperative Nausea and Vomiting-provide-Amnesia, Retrograde', 'Vomiting-provide-Amnesia, Retrograde', 'Osteoarthritis-increase-Arthritis', 'Arthritis, Rheumatoid-predict-Death', 'Appendicitis-droppe-Death', 'Lung Diseases-result-Bronchitis', 'Hyperglycemia-develop-Diabetes Mellitus', 'Emergencies-result-Hyperglycemia', 'Insulin Resistance-result-Hyperglycemia', 'Osteoarthritis, Hip-associated-Fractures, Bone', 'Fractures, Bone-associated-Osteoarthritis, Hip', 'Osteoarthritis, Hip-result-Fractures, Bone', 'Hypertension-associated-Myoclonus', 'Myoclonus-associated-Hypertension', 'Sarcoma-prevent-Retinopathy of Prematurity', 'Hypertrophy, Left Ventricular-associated-Myoclonus', 'Myoclonus-associated-Hypertrophy, Left Ventricular', 'Coronary Artery Disease-dominate-Death', 'Neoplasms-dominate-Death', 'Stroke-dominate-Death', 'Memory Disorders-take-Alzheimer Disease', 'Intestinal Diseases-suggest-Gastrointestinal Diseases', 'Ergotism-investigated-Atrial Fibrillation', 'Multiple Organ Failure-result-Death', 'Neoplasms-become-Chronic Disease', 'Neoplasms-reported-Pain', 'Hypertension-prevent-Diabetes Mellitus', 'Hypertension-prevent-Kidney Diseases', 'Leukoencephalopathies-considered-Dementia', 'Candidiasis, Oral-observed-Mouth Diseases', 'Candidiasis-observed-Mouth Diseases', 'Nervous System Diseases-contribute-Erectile Dysfunction', 'Acquired Immunodeficiency Syndrome-manifest-Dementia', 'Dementia-include-Acquired Immunodeficiency Syndrome', 'Parkinson Disease-sampled-Dystonia', 'Atrioventricular Block-create-Tachycardia', 'Nervous System Diseases-occur-Stroke', 'Hemangioma, Cavernous, Central Nervous System-confirm-Neoplasm Metastasis', 'Neoplasm Metastasis-preclude-Drug-Related Side Effects and Adverse Reactions', 'Infections-follow-Hemorrhage', 'Neoplasm Metastasis-remain-Death', 'Neoplasm Metastasis-remain-Neoplasms', 'Arthritis-cause-Muscle Spasticity', 'Muscular Diseases-cause-Muscle Spasticity', 'Ankle Fractures-cause-Muscle Spasticity', 'Neural Tube Defects-cause-Muscle Spasticity', 'Peripheral Arterial Disease-associated-Hypercholesterolemia', 'Hypercholesterolemia-associated-Peripheral Arterial Disease', 'Peripheral Arterial Disease-confirm-Atherosclerosis', 'Hyperglycemia-demonstrated-Memory Disorders', 'Hyperglycemia-demonstrated-Diabetes Mellitus', 'Vertebrobasilar Insufficiency-shown-Vertigo', 'Vertebrobasilar Insufficiency-shown-Stroke', 'Vertigo-shown-Stroke', 'Thrombocytopenia-present-Exanthema', "Sjogren's Syndrome-present-Exanthema", 'Epilepsy-distinguished-Seizures', 'Telangiectasis-increase-Blepharitis', 'Malnutrition-reduce-Neoplasms', 'Chest Pain-exclude-Myocardial Infarction', 'Cardiovascular Diseases-undergo-Hypertension', 'Diabetes Mellitus-assessed-Ulcer', 'Diabetes Mellitus-assessed-Foot Ulcer', 'Muscle Rigidity-seem-Hypertension', 'Hyperparathyroidism, Primary-determine-Hypercalcemia', 'Diabetes Mellitus-demonstrate-Nerve Degeneration', 'Blood Coagulation Disorders-result-Blood Platelet Disorders', 'Shock, Cardiogenic-associated-Coronary Artery Disease', 'Coronary Artery Disease-associated-Shock, Cardiogenic', 'Angina Pectoris-reduce-Cardiomyopathy, Hypertrophic', 'Heart Failure-reduce-Cardiomyopathy, Hypertrophic', 'Pigmentation Disorders-result-Neuralgia', 'Infections-result-Abnormalities, Drug-Induced', 'Chromosome Aberrations-play-Prostatic Hyperplasia', 'Hyperplasia-cause-Urinary Bladder Neoplasms', 'Hernia-affect-Infections', 'Tuberculosis-seem-Neoplasms', 'Tuberculosis-seem-Infections', 'Muscle Weakness-caused-Gastroenteritis', 'Muscle Weakness-caused-Immunologic Deficiency Syndromes', 'Neuroleptic Malignant Syndrome-carry-Death', 'Neoplasms-demonstrate-Neoplasm Metastasis', 'Alzheimer Disease-immunoreact-Plaque, Amyloid', 'Weight Loss-recommended-Obesity', 'Sarcoma, Kaposi-arise-Immunologic Deficiency Syndromes', 'Death-treated-Hypertension', 'Retinal Diseases-occur-Cataract', 'Retinal Diseases-reflect-Death', 'Hypertrophy, Left Ventricular-combined-Hypertension', 'Hypertrophy, Left Ventricular-increase-Coronary Artery Disease', 'Jaw, Edentulous-altered-Mouth Diseases', 'Coma-defined-Hypothermia', 'Coma-defined-Bradycardia', 'Coma-defined-Infections', 'Coma-defined-Drug Overdose', 'Hypothyroidism-defined-Hypothermia', 'Hypothyroidism-defined-Bradycardia', 'Hypothyroidism-defined-Infections', 'Hypothyroidism-defined-Drug Overdose', 'Pain-limit-Iatrogenic Disease', 'Intestinal Neoplasms-decline-Death', 'Myocardial Infarction-increased-Death', 'Dermatitis-prevent-Urinary Incontinence', 'Carcinogenesis-intervene-Neoplasms', 'Dermatitis-occur-Urinary Incontinence', 'Infarction-retained-Death', 'Infarction-retained-Heart Diseases', 'Neurologic Manifestations-lead-Infections', 'Cerebrovascular Disorders-evaluated-Stroke', 'Hypertension-occur-Obesity', 'Obesity-track-Hyperinsulinism', 'Obesity-track-Hypertension', 'Neoplasms-differentiate-Ulcer', 'Neoplasms-occur-Ulcer', 'Ventricular Fibrillation-reflect-Coronary Artery Disease', 'Ventricular Fibrillation-attributed-Coronary Artery Disease', 'Syncope-cause-Hypotension, Orthostatic', 'Chronic Disease-cause-Hypotension, Orthostatic', 'Jaundice-suggest-Cholestasis', 'Alzheimer Disease-contract-Dementia', 'Dementia, Vascular-contract-Dementia', 'Kidney Diseases-include-Albuminuria', 'Albuminuria-recognized-Hypertension', 'Albuminuria-associated-Hypertrophy, Left Ventricular', 'Hypertrophy, Left Ventricular-associated-Albuminuria', 'Kidney Diseases-emerge-Renal Insufficiency', 'Kidney Diseases-emerge-Hypertension', 'Nephrosclerosis-emerge-Renal Insufficiency', 'Nephrosclerosis-emerge-Hypertension', 'Albuminuria-associated-Neurologic Manifestations', 'Neurologic Manifestations-associated-Albuminuria', 'Alzheimer Disease-evaluate-Cerebral Hemorrhage', 'Dementia, Vascular-compared-Cerebral Hemorrhage', 'Dementia, Vascular-evaluate-Cerebral Hemorrhage', 'Atrophy-fail-Dementia', 'Atrophy-separate-Dementia', 'Hyperplasia-associated-Kidney Calculi', 'Kidney Calculi-associated-Hyperplasia', 'Wounds and Injuries-restore-Immunologic Deficiency Syndromes', 'Neoplasms-restore-Immunologic Deficiency Syndromes', 'Acquired Immunodeficiency Syndrome-lead-Wounds and Injuries', 'Substance-Related Disorders-lead-Wounds and Injuries', 'Cerebrovascular Disorders-lead-Wounds and Injuries', 'Coronary Artery Disease-increased-Diabetes Mellitus', 'Peripheral Vascular Diseases-increased-Diabetes Mellitus', 'Cerebrovascular Disorders-increased-Diabetes Mellitus', 'Hypertension-increased-Diabetes Mellitus', 'Coronary Artery Disease-report-Cardiovascular Diseases', 'Cardiovascular Diseases-bear-Osteoporosis', 'Myocardial Infarction-prevent-Coronary Thrombosis', 'Myocardial Infarction-prevent-Coronary Artery Disease', 'Myocardial Infarction-prevent-Stroke', 'Pain Insensitivity, Congenital-worsen-Pain', 'Death-mediated-Coronary Artery Disease', 'Arthritis, Rheumatoid-followed-Arthritis', 'Arthritis, Rheumatoid-followed-Rheumatic Diseases', 'Infections-identified-Respiratory Tract Diseases', 'Tetany-include-Embolism', 'Tetany-include-Pneumonia, Aspiration', 'Pain-evaluated-Ulcer', 'Pain-evaluated-Myocardial Infarction', 'Leukemia, Myeloid, Acute-compared-Myelodysplastic Syndromes', 'Leukemia, Myeloid, Acute-develop-Myelodysplastic Syndromes', 'Leukemia, Myeloid, Acute-compared-Precursor Cell Lymphoblastic Leukemia-Lymphoma', 'Myelodysplastic Syndromes-develop-Precursor Cell Lymphoblastic Leukemia-Lymphoma', 'Drug-Related Side Effects and Adverse Reactions-appear-Drug Overdose', 'Kidney Diseases-associated-Gastrointestinal Hemorrhage', 'Gastrointestinal Hemorrhage-associated-Kidney Diseases', 'Kidney Diseases-increased-Death', 'Alcoholism-mimic-Diabetes Mellitus', 'Alcoholism-mimic-Delirium', 'Alcoholism-mimic-Stroke', 'Alcoholism-mimic-Myocardial Infarction', 'Alcoholism-mimic-Heart Failure', 'Thyroid Crisis-monitored-Respiratory Tract Infections', 'Dyspnea-suspect-Malabsorption Syndromes', 'Papilledema-protected-Optic Nerve Neoplasms', 'Communication Disorders-associated-Parkinson Disease', 'Parkinson Disease-associated-Communication Disorders', 'Gastroenteritis-involve-Death', 'Death-involve-Gastroenteritis', 'Atherosclerosis-lead-Hypertension', 'Arteriosclerosis-lead-Hypertension', 'Sleep Initiation and Maintenance Disorders-lead-Hypertension', 'Stroke-prevent-Hypertension', 'Neuromuscular Diseases-precede-Pneumonia', 'Death-follow-Cross Infection', 'Fibrosis-differ-Emphysematous Cholecystitis', 'Atrophy-measure-Hepatomegaly', 'Menstruation Disturbances-exhibit-Musculoskeletal Diseases', 'Osteosarcoma-develop-Keratosis, Seborrheic', 'Keratosis, Seborrheic-associated-Neoplasms', 'Neoplasms-associated-Keratosis, Seborrheic', 'Neoplasms-impact-Drug-Related Side Effects and Adverse Reactions', 'Dystonia-begin-Paresis', 'Sexual Dysfunction, Physiological-occur-Neoplasms', 'Athetosis-begin-Paresis', 'Erectile Dysfunction-occur-Neoplasms', 'Dysarthria-begin-Paresis', 'Deglutition Disorders-begin-Paresis', 'Heart Block-include-Bradycardia', 'Leukoaraiosis-contribute-Dementia', 'Leukoaraiosis-contribute-Ischemia', 'Jaundice-become-Multiple Chronic Conditions', 'Dementia-contribute-Ischemia', 'Cholestasis, Intrahepatic-become-Multiple Chronic Conditions', 'Dementia-contribute-Leukoaraiosis', 'Movement Disorders-include-Cholestasis, Intrahepatic', 'Dementia-contribute-Retinal Degeneration', 'Ischemia-contribute-Leukoaraiosis', 'Cholestasis, Intrahepatic-result-Jaundice', 'Chronic Disease-make-Alzheimer Disease', 'Hypotension-increase-Cerebral Infarction', 'Hypotension-increase-Stroke', 'Alzheimer Disease-categorized-Dementia', 'Death-connected-Femoral Neck Fractures', 'Airway Obstruction-cause-Epididymitis', 'Leukoaraiosis-attributed-Hypertension', 'Hypercalcemia-develop-Hyperparathyroidism', 'Wounds and Injuries-tolerated-Brain Injuries', 'Neoplasms-investigate-Hyperparathyroidism', 'Seizures-lead-Epilepsy', 'Neurologic Manifestations-render-Neurotoxicity Syndromes', 'Status Epilepticus-indicate-Seizures', 'Status Epilepticus-occur-Death', 'Breast Neoplasms-exceed-Neoplasms', 'Wounds and Injuries-consider-Seizures', 'Wounds and Injuries-consider-Craniocerebral Trauma', 'Seizures-combined-Brain Diseases', 'Seizures-combined-Neurologic Manifestations', 'Brain Diseases-combined-Neurologic Manifestations', 'Neurologic Manifestations-associated-Seizures', 'Seizures-associated-Neurologic Manifestations', 'Seizures-associated-Wounds and Injuries', 'Wounds and Injuries-associated-Seizures', 'Urinary Bladder, Neurogenic-cause-Erectile Dysfunction', 'Erectile Dysfunction-cause-Diabetes Mellitus', 'Carcinoid Tumor-cause-Jaundice, Obstructive', 'Esophageal Neoplasms-contribute-Protein-Energy Malnutrition', 'Neoplasms-contribute-Protein-Energy Malnutrition', 'Pregnancy Complications, Infectious-follow-Neoplasms', 'Cachexia-attributed-Thyroiditis', 'Protein-Energy Malnutrition-play-Neoplasms', 'Adrenocortical Carcinoma-proposed-Addison Disease', 'Polyuria-found-Pancreatitis', 'Polyuria-found-Diabetes Mellitus', 'Pancreatitis-found-Diabetes Mellitus', 'Ulcer-found-Gastroesophageal Reflux', 'Gastroesophageal Reflux-cause-Death', 'Arthritis, Rheumatoid-present-Cerebrovascular Disorders', 'Hypercholesterolemia-reduce-Myocardial Infarction', 'Brain Ischemia-provoked-Hypertension', 'Brain Ischemia-provoked-Stroke', 'Atrioventricular Block-paced-Heart Diseases', 'Atrioventricular Block-paced-Heart Failure', 'Neoplasms, Multiple Primary-treated-Atrioventricular Block', 'Stroke-followed-Infections', 'Stroke-followed-Parkinson Disease, Secondary', 'Myocardial Infarction-followed-Infarction', 'Hemorrhage-occur-Fibrosis', 'Fibrosis-survive-Hemorrhage', 'Hemorrhage-prevent-Death', 'Hemorrhage-associated-Brain Diseases', 'Brain Diseases-associated-Hemorrhage', 'Death-predict-Stroke', 'Pain-correct-Musculoskeletal Diseases', 'Neoplasms-show-Colorectal Neoplasms', 'Ovarian Diseases-produce-Death', 'Hypercholesterolemia-associated-Coronary Artery Disease', 'Coronary Artery Disease-associated-Hypercholesterolemia', 'Dyskinesia, Drug-Induced-occur-Dementia', 'Hypothalamic Neoplasms-suffer-Brain Ischemia', 'Hypothalamic Neoplasms-protected-Ischemia', 'Albuminuria-reflect-Hypertension', 'Hypertension, Malignant-recognized-Hypertension', 'Kidney Diseases-seen-Diabetes Mellitus', 'Infections-manifest-Headache Disorders, Secondary', 'Stroke-estimated-Death', 'Stroke-apply-Death', 'Death-give-Stroke', 'Chest Pain-result-Death', 'Vascular Calcification-associated-Hypertension', 'Hypertension-associated-Vascular Calcification', 'Hypertension-decreased-Myocardial Infarction', 'Neoplasms-searched-Lipoma', 'Pain-disappear-Ulcer', 'Chronic Disease-become-Neoplasms', 'Neoplasms-withhold-Death', 'Chronic Disease-withhold-Death', 'Joint Diseases-affected-Arthritis, Rheumatoid', 'Death-listed-Diarrhea', 'Diarrhea-listed-Death', 'Sinusitis-produce-Fragile X Syndrome', 'Sinusitis-bleed-Hemorrhage', 'Fragile X Syndrome-bleed-Hemorrhage', 'Hypotension-associated-Thinness', 'Thinness-associated-Hypotension', 'Hypotension-show-Thinness', 'Death-include-Acquired Immunodeficiency Syndrome', 'Acquired Immunodeficiency Syndrome-include-HIV Infections', 'Pneumonia-include-HIV Infections', 'Sepsis-include-HIV Infections', 'Respiratory Tract Diseases-include-HIV Infections', 'Pneumonia-include-Acquired Immunodeficiency Syndrome', 'Sepsis-include-Acquired Immunodeficiency Syndrome', 'Respiratory Tract Diseases-include-Acquired Immunodeficiency Syndrome', 'Communicable Diseases-decline-Death', 'Death-decline-Neurodegenerative Diseases', 'Death-decline-Cardiovascular Diseases', 'Diabetes Mellitus-receive-Substance-Related Disorders', 'Neoplasm Metastasis-based-Neoplasms', 'Arthritis-found-Exanthema', 'Arthritis-found-Kidney Diseases', 'Drug-Related Side Effects and Adverse Reactions-computed-Arthritis, Rheumatoid', 'Gingivitis-control-Pain', 'Lens Diseases-noted-Cataract', 'Hypotension-treated-Heart Diseases', 'Heart Diseases-include-Heart Failure', 'Carcinogenesis-interprete-Neoplasms', 'Pain-isolate-Dyspnea', 'Lung Diseases-encountered-Alcoholism', 'Colitis, Ulcerative-continue-Crohn Disease', 'Esophageal Neoplasms-observed-Adenocarcinoma', 'Genetic Diseases, Inborn-appear-Hypercholesterolemia', 'Death-include-Sleep Initiation and Maintenance Disorders', 'Hemorrhage-prevent-Stroke', 'Polymyalgia Rheumatica-distinguish-Arthritis, Rheumatoid', 'Death-lower-Cholecystitis, Acute', 'Abdominal Pain-followed-Fever', 'Signs and Symptoms, Respiratory-grouped-Asthma', 'Signs and Symptoms, Respiratory-grouped-Respiratory Sounds', 'Signs and Symptoms, Respiratory-grouped-Cough', 'Signs and Symptoms, Respiratory-grouped-Rhinitis, Allergic, Seasonal', 'Osteoarthritis-performed-Tooth Loss', 'Infections-related-Death', 'Arbovirus Infections-expanding-HIV Infections', 'Dermatitis-include-Skin Diseases', 'Jaw, Edentulous-declining-Periodontitis', 'Tooth Loss-declining-Periodontitis', 'Death-cause-Arteritis', 'Arteritis-cause-Death', 'Autonomic Dysreflexia-occur-Spinal Cord Diseases', 'Autonomic Dysreflexia-include-Seizures', 'Autonomic Dysreflexia-include-Stroke', 'Autonomic Dysreflexia-include-Arrhythmias, Cardiac', 'Quadriplegia-induced-Atrial Fibrillation', 'Autonomic Dysreflexia-include-Atrial Fibrillation', 'Autonomic Dysreflexia-cause-Arrhythmias, Cardiac', 'Quadriplegia-induced-Autonomic Dysreflexia', 'Atrial Fibrillation-induced-Autonomic Dysreflexia', 'Atrial Fibrillation-associated-Autonomic Dysreflexia', 'Autonomic Dysreflexia-associated-Atrial Fibrillation', 'Osteoarthritis-compared-Femoral Neoplasms', 'Sleep Wake Disorders-involved-Erectile Dysfunction', 'Osteosarcoma-follow-Neoplasms', 'Breast Neoplasms-diagnose-Neoplasms', 'Hypotension-manage-Diabetes Mellitus', 'Heart Rupture-develop-Chest Pain', 'Heart Rupture-develop-Myocardial Infarction', 'Chest Pain-develop-Myocardial Infarction', 'Aortic Diseases-represent-Cerebral Hemorrhage', 'Wolff-Parkinson-White Syndrome-compare-Arrhythmias, Cardiac', 'Syncope-report-Tachycardia', 'Urinary Incontinence-manifest-Reflex, Abnormal', 'Scoliosis-assess-Respiratory Insufficiency', 'Scoliosis-lead-Respiratory Insufficiency', 'Respiratory Insufficiency-develop-Scoliosis', 'Hyperkinesis-implicated-Hypertension', 'Hypertension-reverse-Cardiomyopathy, Hypertrophic', 'Diabetes Mellitus-reverse-Cardiomyopathy, Hypertrophic', 'Cerebral Amyloid Angiopathy-recognized-Cerebral Hemorrhage', 'Hemorrhage-produce-Dementia', 'Hemorrhage-consist-Hypertension', 'Hematoma, Subdural-develop-Wounds and Injuries', 'Sexual Dysfunction, Physiological-attributed-Immunologic Deficiency Syndromes', 'Epilepsy-attributed-Immunologic Deficiency Syndromes', 'Arteriolosclerosis-accelerated-Hypertension', 'Stroke-surpass-Heart Diseases', 'Stroke-surpass-Neoplasms', 'Death-surpass-Neoplasms', 'Brain Ischemia-aimed-Infarction', 'Stroke-receive-Atherosclerosis', 'Coronary Artery Disease-double-Atrial Fibrillation', 'Coronary Artery Disease-double-Stroke', 'Heart Failure-double-Atrial Fibrillation', 'Heart Failure-double-Stroke', 'Atrial Fibrillation-double-Stroke', 'Atrial Fibrillation-exert-Stroke', 'Carotid Artery Diseases-detected-Aneurysm', 'Stroke-decrease-Atrial Fibrillation', 'Pneumonia-predispose-Respiratory Tract Infections', 'Sleep Deprivation-produce-Muscle Hypertonia', 'Heart Failure-identify-Myocardial Infarction', 'Stroke-identify-Myocardial Infarction', 'Hypertension-appear-Cardiac Output, High', 'Hypertension-measure-Stroke', 'Hyperparathyroidism, Primary-studied-Chondrocalcinosis', 'Hyperparathyroidism, Primary-studied-Crystal Arthropathies', 'Chondrocalcinosis-occur-Hyperparathyroidism', 'Chondrocalcinosis-occur-Arthritis', 'Hyperparathyroidism-occur-Arthritis', 'Plaque, Amyloid-accompany-Heart Failure', 'Heart Failure-accompany-Amyloidosis', 'Muscle Hypertonia-produce-Disease Progression', 'Ulcer-move-Musculoskeletal Diseases', 'Ulcer-move-Nervous System Diseases', 'Leukemia, Myeloid, Acute-recognized-Leukemia', 'Leukemia, Myeloid, Acute-defined-Bone Marrow Diseases', 'Leukemia-defined-Bone Marrow Diseases', 'Arteritis-include-Inflammation', 'Fibrosis-include-Arteritis', 'Central Nervous System Diseases-underlie-Reflex, Abnormal', 'Central Nervous System Diseases-underlie-Urinary Incontinence', 'Lewy Body Disease-designate-Dementia', 'Infections-occur-Vascular System Injuries', 'Infections-occur-Neurologic Manifestations', 'Granuloma-represent-Urination Disorders', 'Dystonia-suffer-Chronic Disease', 'Tuberculosis-considered-Drug-Related Side Effects and Adverse Reactions', 'Infections-accomplish-Tuberculosis', 'Embolism-increase-Stroke', 'Stroke-considered-Coronary Artery Disease', 'Neoplasms-considered-Coronary Artery Disease', 'Postpartum Hemorrhage-precipitate-Hypotension, Orthostatic', 'Postpartum Hemorrhage-precipitate-Hypertension', 'Hypotension, Orthostatic-precipitate-Hypertension', 'Respiratory Tract Infections-dominated-Hypertension', 'Respiratory Tract Infections-dominated-Diabetes Mellitus', 'Hypertension-cause-Stroke', 'Hypertension-cause-Demyelinating Diseases', 'Cataract-correspond-Chronic Disease', 'Cerebrovascular Disorders-occur-Stroke', 'Cerebrovascular Disorders-occur-Ischemia', 'Drug Hypersensitivity-lead-Diabetes Mellitus', 'Hearing Disorders-affected-Dementia', 'Death-result-Central Nervous System Diseases', 'Breast Neoplasms-associated-Facial Dermatoses', 'Facial Dermatoses-associated-Breast Neoplasms', 'Facial Dermatoses-suggest-Neoplasms', 'Chest Pain-associated-Headache', 'Headache-associated-Chest Pain', 'Hyperparathyroidism-undergo-Hypercalcemia', 'Parathyroid Neoplasms-cause-Hypercalcemia', 'Parathyroid Neoplasms-cause-Hyperparathyroidism', 'Mesonephroma-cause-Hypercalcemia', 'Mesonephroma-cause-Hyperparathyroidism', 'Periarthritis-examined-Diabetes Mellitus, Type 2', 'Apnea-related-Dementia', 'Apnea-related-Death', 'Musculoskeletal Diseases-related-Pain', 'Constipation-defined-Short Bowel Syndrome', 'Joint Diseases-prevent-Hemorrhage', 'Gastroesophageal Reflux-referred-Headache Disorders, Secondary', 'Gastroesophageal Reflux-referred-Anemia', 'Neuromuscular Junction Diseases-include-Pain', 'Chest Pain-compare-Angina Pectoris', 'Infections-associated-Skin Ulcer', 'Skin Ulcer-associated-Infections', 'Mesothelioma-include-Neoplasms', 'Death-tested-Pneumococcal Infections', 'Ischemia-play-Aneurysm', 'Ischemia-play-Atrophy', 'Aneurysm-play-Atrophy', 'Death-examined-Hip Fractures', 'Hypertension, Pulmonary-considered-Dyspnea', 'Hypertension, Pulmonary-considered-Chest Pain', 'Infections-prove-Fever', 'Alzheimer Disease-separated-Dementia', 'Alzheimer Disease-report-Chronic Disease', 'Plaque, Amyloid-described-Alzheimer Disease', 'Death-result-Thromboembolism', 'Heart Arrest-derived-Werner Syndrome', 'Viremia-observed-HIV Infections', 'Cardiovascular Diseases-discussed-Cardiomyopathy, Hypertrophic', 'Blindness-used-Hypoxia', 'Blindness-used-Ischemia', 'Hypertension-accompanied-Immunologic Deficiency Syndromes', 'Cardiovascular Diseases-induce-Heart Diseases', 'Rheumatic Diseases-occur-HIV Infections', 'Diabetes Mellitus-tend-Atherosclerosis', 'Cardiovascular Diseases-evaluate-Intellectual Disability', 'Seizures-evaluate-Cardiovascular Diseases', 'Seizures-evaluate-Intellectual Disability', 'Liver Cirrhosis-diagnosed-Endocarditis', 'Cardiovascular Diseases-suggest-Death', 'Intellectual Disability-suggest-Death', 'Hypotension-cause-Sleep Wake Disorders', 'Atherosclerosis-develop-Bone Diseases, Metabolic', 'Renal Artery Obstruction-assessed-Stroke', 'Stroke-associated-Constriction, Pathologic', 'Constriction, Pathologic-associated-Stroke', 'Alzheimer Disease-demonstrate-Hydrocephalus', 'Hypoxia-respond-Bradycardia', 'Aneurysm-suspected-Hypertension', 'Aneurysm-suspected-Kidney Diseases', 'Pain-caused-Diabetes Mellitus', 'Peripheral Nervous System Diseases-caused-Diabetes Mellitus', 'Corneal Diseases-affected-Ocular Hypertension', 'Hypothermia-associated-Heart Failure', 'Heart Failure-associated-Hypothermia', 'Hypothermia-associated-Respiratory Insufficiency', 'Respiratory Insufficiency-associated-Hypothermia', 'Hypothermia-associated-Stroke', 'Stroke-associated-Hypothermia', 'Hypothermia-associated-Hemorrhage', 'Hemorrhage-associated-Hypothermia', 'Hypothermia-identify-Death', 'Congenital Hypothyroidism-lead-Thyroid Nodule', 'Urinary Incontinence-compared-Urinary Incontinence, Urge', 'Neurologic Manifestations-defined-Death', 'Cerebrovascular Disorders-discussed-Stroke', 'Thyroid Neoplasms-base-Neoplasms', 'Headache Disorders, Secondary-referred-Pain', 'Dementia-evidenced-Memory Disorders', 'Angina Pectoris-compromised-Headache Disorders, Secondary', 'Prostatic Neoplasms-comprise-Neoplasms', 'Prostatic Neoplasms-reported-Neoplasms', 'Death-constitute-Neoplasms', 'Death-constitute-Prostatic Neoplasms', 'Neoplasms-constitute-Prostatic Neoplasms', 'Movement Disorders-predate-Parkinson Disease', 'Arteritis-differentiate-Headache', 'Acquired Immunodeficiency Syndrome-play-HIV Infections', 'Fractures, Bone-contribute-Wounds and Injuries', 'Hyperplasia-identified-Arthritis, Rheumatoid', 'Hyperplasia-identified-Wounds and Injuries', 'Hyperplasia-identified-Dermatomycoses', 'Hyperplasia-identified-HIV Infections', 'Death-develop-Lymphoma, Non-Hodgkin', 'Colitis, Collagenous-characterized-Diarrhea', 'Lymphoma, B-Cell-make-Lymphoma', 'Lymphoma, B-Cell-make-Neoplasms', 'Parkinson Disease, Secondary-referred-Parkinson Disease', 'Parkinson Disease, Secondary-compared-Parkinson Disease', 'Neoplasms-composed-Leukemia, Lymphocytic, Chronic, B-Cell', 'Rheumatic Diseases-associated-Arthritis, Rheumatoid', 'Arthritis, Rheumatoid-associated-Rheumatic Diseases', 'Peptic Ulcer-experience-Ulcer', 'Peptic Ulcer-experience-Hemorrhage', 'Peptic Ulcer-imposed-Pain', 'Peptic Ulcer-present-Hemorrhage', 'Pain-imposed-Hemorrhage', 'Arthritis, Rheumatoid-recognize-Renal Insufficiency', 'Gout-recognize-Renal Insufficiency', 'Hyperuricemia-represent-Death', 'Nerve Degeneration-studied-Alzheimer Disease', 'Nerve Degeneration-studied-Parkinson Disease', 'Nerve Degeneration-studied-Supranuclear Palsy, Progressive', 'Diabetes Mellitus-studied-Supranuclear Palsy, Progressive', 'Heart Diseases-studied-Alzheimer Disease', 'Heart Diseases-studied-Parkinson Disease', 'Heart Diseases-studied-Supranuclear Palsy, Progressive', 'Alzheimer Disease-reveal-Gliosis', 'Alzheimer Disease-reveal-Infarction', 'Alzheimer Disease-reveal-Hypertension', 'Gliosis-reveal-Infarction', 'Cerebrovascular Disorders-present-Brain Diseases', 'Gliosis-reveal-Hypertension', 'Hypertension-decrease-Hypotension', 'Hypotension-decrease-Death', 'Sleep Initiation and Maintenance Disorders-receive-Death', 'Death-preceded-Arrhythmias, Cardiac', 'Death-require-Heart Failure', 'Arrhythmias, Cardiac-require-Heart Failure', 'Obesity-protect-Hypertension', 'Obesity-protect-Cardiovascular Diseases', 'Hypertension-protect-Cardiovascular Diseases', 'Alzheimer Disease-account-Dementia, Vascular', 'Dementia-diagnosed-Ischemia', 'Dementia-use-Ischemia', 'Dementia, Vascular-included-Hypertension', 'Atrophy-measured-Alzheimer Disease', 'Hypertension-benefit-Seizures', 'Hyperplasia-consist-Neoplasms', 'Diabetes Mellitus-identified-Neurologic Manifestations', 'Dyspareunia-lead-Erectile Dysfunction', 'Death-attributed-Hemorrhage', 'Atrial Fibrillation-explained-Edema', 'Basal Ganglia Hemorrhage-suffer-Craniocerebral Trauma', "Gastritis, Atrophic-occur-Sjogren's Syndrome", 'Cough-play-Atrophy', 'Microtrauma, Physical-play-Atrophy', 'Alzheimer Disease-observed-Vision Disorders', 'Acute Disease-occur-Craniocerebral Trauma', 'Cerebrospinal Fluid Rhinorrhea-occur-Craniocerebral Trauma', 'Alzheimer Disease-score-Dementia', 'Vision Disorders-related-Alzheimer Disease', 'Renal Insufficiency-accelerated-Denys-Drash Syndrome', 'Denys-Drash Syndrome-accelerated-Hypertension', 'Denys-Drash Syndrome-accelerated-Atherosclerosis', 'Hypertension-promote-Atherosclerosis', 'Hypertension-appear-Kidney Diseases', 'Asthma-lead-Airway Obstruction', 'Asthma-mimic-Pulmonary Disease, Chronic Obstructive', 'Weight Loss-predominate-Goiter', 'Aneurysm-assessed-Hypertension', 'Heart Failure-related-Hypertension, Pulmonary', 'Heart Failure-related-Arrhythmias, Cardiac', 'Heart Failure-related-Infections', 'Heart Failure-related-Cardiovascular Diseases', 'Osteoporosis-minimize-Bone Neoplasms', 'Heart Failure-compare-Heart Failure, Systolic', 'Endocrine System Diseases-associated-Epilepsy', 'Epilepsy-associated-Endocrine System Diseases', 'Sexual Dysfunction, Physiological-exacerbate-Seizures', 'Epilepsy-associated-Hypogonadism', 'Hypogonadism-associated-Epilepsy', 'Epilepsy-associated-Chiari-Frommel Syndrome', 'Chiari-Frommel Syndrome-associated-Epilepsy', 'Amnesia-include-Intracranial Aneurysm', 'Amnesia-caused-Intracranial Aneurysm', 'Korsakoff Syndrome-caused-Intracranial Aneurysm', 'Breast Neoplasms-evolve-Neoplasm Metastasis', 'Meningeal Neoplasms-manifest-Stroke', 'Fractures, Bone-prevent-Bone Neoplasms', 'Bone Neoplasms-fall-Cardiac Output, Low', 'Meningeal Neoplasms-associated-Hemorrhage', 'Hemorrhage-associated-Meningeal Neoplasms', 'Subarachnoid Hemorrhage-originate-Meningeal Neoplasms', 'Cerebrovascular Disorders-result-Stroke', 'Ascites-appear-Peritonitis, Tuberculous', 'Chronic Disease-associated-Wounds and Injuries', 'Wounds and Injuries-associated-Chronic Disease', 'Osteoporosis-accompanied-Pain', 'Osteoporosis-accompanied-Spinal Diseases', 'Xerostomia-linked-Esophageal Neoplasms', 'Autoimmune Diseases of the Nervous System-result-Salivary Gland Diseases', "Infections-diagnosed-Legionnaires' Disease", 'Cough-referred-Bronchial Neoplasms', 'Atherosclerosis-accelerate-Hyperkinesis', 'Cardiomyopathy, Dilated-result-Heart Diseases', 'Chemical and Drug Induced Liver Injury-obtain-Hepatitis B', 'Hemorrhage-increased-Neoplasms', 'Heart Diseases-result-Ascites', 'Heart Diseases-result-Hepatomegaly', 'Cholangitis, Sclerosing-result-Fibrosis', 'Hepatitis, Autoimmune-result-Fibrosis', 'Gastrointestinal Hemorrhage-do-Death', 'Deglutition Disorders-forgott-Central Nervous System Diseases', 'Ulcer-arise-Headache Disorders, Secondary', 'Ulcer-arise-Death', 'Hypoxia-cause-Eye Diseases', 'Hypoxia-cause-Glaucoma', 'Testicular Neoplasms-grouped-Seminoma', 'Central Nervous System Diseases-increase-Fibrosis', 'Central Nervous System Diseases-indicate-Alcoholism', 'Fibrosis-indicate-Alcoholism', 'Appendicitis-differentiated-Pelvic Inflammatory Disease', 'Erectile Dysfunction-treat-Hypogonadism', 'Neoplasms-afflict-Gallstones', 'Myelodysplastic Syndromes-demonstrated-Leukemia, Myeloid, Acute', 'Drug-Related Side Effects and Adverse Reactions-evaluated-Arthritis, Rheumatoid', 'Drug-Related Side Effects and Adverse Reactions-evaluated-Arthritis', 'Drug-Related Side Effects and Adverse Reactions-evaluated-Rheumatic Diseases', 'Arthritis, Rheumatoid-enrolled-Arthritis', 'Death-invite-Coronary Artery Disease', 'Death-invite-Myocardial Infarction', 'Death-invite-Cerebrovascular Disorders', 'Death-invite-Atherosclerosis', 'Arteriosclerosis-represent-Death', 'Chronic Kidney Disease-Mineral and Bone Disorder-used-Kidney Failure, Chronic', 'Chronic Kidney Disease-Mineral and Bone Disorder-include-Kidney Failure, Chronic', 'Chronic Kidney Disease-Mineral and Bone Disorder-include-Fibrous Dysplasia of Bone', 'Chronic Kidney Disease-Mineral and Bone Disorder-used-Fibrous Dysplasia of Bone', 'Chronic Kidney Disease-Mineral and Bone Disorder-include-Osteomalacia', 'Chronic Kidney Disease-Mineral and Bone Disorder-used-Osteomalacia', 'Chronic Kidney Disease-Mineral and Bone Disorder-include-Osteosclerosis', 'Chronic Kidney Disease-Mineral and Bone Disorder-used-Osteosclerosis', 'Chronic Kidney Disease-Mineral and Bone Disorder-include-Osteoporosis', 'Chronic Kidney Disease-Mineral and Bone Disorder-used-Osteoporosis', 'Kidney Failure, Chronic-used-Fibrous Dysplasia of Bone', 'Kidney Failure, Chronic-used-Osteomalacia', 'Kidney Failure, Chronic-used-Osteosclerosis', 'Kidney Failure, Chronic-used-Osteoporosis', 'Glomerulonephritis-decrease-Polycystic Kidney Diseases', 'Diabetic Nephropathies-decrease-Polycystic Kidney Diseases', 'Kidney Failure, Chronic-develop-Neoplasms', 'Hypertension-decrease-Polycystic Kidney Diseases', 'Polycystic Kidney Diseases-develop-Neoplasms', 'Hyperphosphatemia-induce-Vascular Calcification', 'Nerve Degeneration-indicate-Chronic Disease', 'Diabetes Mellitus, Type 2-increased-Hypertension', 'Hypertension-accelerate-Heart Diseases', 'Hypertension-accelerate-Stroke', 'Hypertension-accelerate-Peripheral Vascular Diseases', 'Hypertension-accelerate-Retinal Diseases', 'Hypertension-accelerate-Kidney Diseases', 'Diabetes Mellitus-accelerate-Heart Diseases', 'Diabetes Mellitus-accelerate-Stroke', 'Diabetes Mellitus-accelerate-Peripheral Vascular Diseases', 'Diabetes Mellitus-accelerate-Retinal Diseases', 'Diabetes Mellitus-accelerate-Kidney Diseases', 'Osteoarthritis-graded-Bone Cysts', 'Osteoarthritis-graded-Periodontal Cyst', 'Carbohydrate Metabolism, Inborn Errors-exist-Hypertension', 'Carbohydrate Metabolism, Inborn Errors-contribute-Cardiovascular Diseases', 'Obesity-precede-Osteoarthritis', 'Parkinsonian Disorders-underlie-Parkinson Disease', 'Wounds and Injuries-dealt-Fractures, Bone', 'Osteoarthritis-include-Knee Injuries', 'Osteoarthritis-include-Chondrocalcinosis', 'Arthritis-identified-Pain', 'Hypertension-stop-Cough', 'Calcinosis-show-Coronary Stenosis', 'Calcinosis-show-Constriction, Pathologic', 'Brain Diseases-accounted-Cerebral Infarction', 'Infarction, Posterior Cerebral Artery-caused-Atrial Fibrillation', 'Diabetes Mellitus-gratified-Neoplasms', 'Death-gratified-Neoplasms', 'Weight Loss-associated-Diarrhea', 'Diarrhea-associated-Weight Loss', 'Weight Loss-associated-Steatorrhea', 'Steatorrhea-associated-Weight Loss', 'Cardiomyopathy, Hypertrophic-include-Hypertension', 'Joint Diseases-develop-Arthritis', 'Arthritis-develop-Wounds and Injuries', 'Osteoporotic Fractures-show-Fractures, Stress', 'Death-contribute-Hip Fractures', 'Hemorrhage-include-Retinal Detachment', 'Heart Failure-precipitated-Myocardial Infarction', 'Heart Failure-precipitated-Hypertension', 'Weight Loss-related-Malnutrition', 'Death-survive-Wounds and Injuries', 'Death-performed-Jaundice, Obstructive', 'Jaundice, Obstructive-reflect-Death', 'Jaundice, Obstructive-performed-Jaundice', 'Myocardial Infarction-show-Angina Pectoris', 'Coronary Artery Disease-doubled-Death', 'Coronary Artery Disease-shown-Death', 'Cross Infection-increase-Infections', 'Neoplasms-cited-Cross Infection', 'Chronic Disease-cited-Cross Infection', 'Neoplasms-found-Infections', 'Pericardial Effusion-occur-Hypothyroidism', 'Hypothyroidism-reassess-Pericardial Effusion', 'Pericardial Effusion-attributed-Hypothyroidism', 'Diabetes Mellitus-accompanied-Atherosclerosis', 'Marfan Syndrome-associated-Hypogonadism', 'Hypogonadism-associated-Marfan Syndrome', 'Diabetes Mellitus-recommended-Cholecystitis', 'Gallstones-recommended-Cholecystitis', 'Cholecystitis-seem-Diabetes Mellitus', 'Cholecystitis-seem-Communicable Diseases', 'Hypoxia-include-Postoperative Complications', 'Nerve Degeneration-cause-Death', 'Hypothyroidism-screen-Thyroid Diseases', 'Hypoxia-cause-Death', 'Death-compared-Cardiovascular Diseases', 'Death-compared-Coronary Artery Disease', 'Nausea-test-Death', 'Vomiting-test-Death', 'Headache-test-Death', 'Earache-test-Death', 'Alzheimer Disease-proposed-Hypothalamic Diseases', 'Hypoglycemia-produce-Kidney Diseases', 'Musculoskeletal Diseases-influenced-Foreign Bodies', 'Glaucoma-measure-Ocular Hypertension', 'Hypothyroidism-diagnosed-Hyperthyroidism', 'Hypothyroidism-diagnosed-Thyroid Diseases', 'Kyphosis-result-Osteoporosis', 'Diabetes Mellitus-contribute-Erectile Dysfunction', 'Malnutrition-affect-Chronic Disease', 'Malnutrition-affect-Diabetes Mellitus', 'Obesity-lead-Atherosclerosis', 'Diabetes Mellitus, Type 2-lead-Atherosclerosis', 'Hypertension-lead-Atherosclerosis', 'Diabetes Mellitus, Type 2-treated-Hypoglycemia', 'Hypoglycemia-obviate-Malnutrition', 'Renal Insufficiency-obviate-Malnutrition', 'Hyperglycemia-improve-Diabetes Mellitus', 'Glomerulonephritis-shown-Systemic Vasculitis', 'Glomerulonephritis-associated-Systemic Vasculitis', 'Systemic Vasculitis-associated-Glomerulonephritis', 'Hematuria-uncover-Neoplasms', 'Kidney Diseases-account-Nephrotic Syndrome', 'Nephrotic Syndrome-follow-Acute Kidney Injury', 'Hypoaldosteronism-associated-Hyperkalemia', 'Hyperkalemia-associated-Hypoaldosteronism', 'Cerebrovascular Disorders-include-Chronic Disease', 'Sleep Wake Disorders-accompanied-Apnea', 'Hypertension-pose-Hypertension, Renovascular', 'Colitis-induce-Infections', 'Weight Loss-result-Dementia', 'Weight Loss-result-Malnutrition', 'Dementia-result-Malnutrition', 'Infertility, Female-include-Endometriosis', 'Infertility, Female-include-Neurologic Manifestations', 'Death-correlate-Smoke Inhalation Injury', 'Lung Diseases-associated-Cross Infection', 'Cross Infection-associated-Lung Diseases', 'Cardiomyopathies-observed-Hypertrophy', 'Atrial Fibrillation-carry-Thromboembolism', 'Fatty Liver-prevent-Stroke', 'Granuloma-produce-Fibrosis', 'Hypoxia-controlled-Pneumonia', 'Chronic Disease-result-Pneumonia', 'Werner Syndrome-define-Neoplasms', 'Werner Syndrome-define-Atherosclerosis', 'Metabolic Diseases-start-Nerve Degeneration', 'Metabolic Diseases-regarded-Nerve Degeneration', 'Metabolic Diseases-regarded-Death', 'Nerve Degeneration-regarded-Death', 'Delirium-clear-Urinary Tract Infections', 'Urinary Tract Infections-show-Fever', 'Urinary Tract Infections-show-Leukocytosis', 'Urinary Tract Infections-precipitate-Delirium', 'Dyskinesia, Drug-Induced-include-Dystonia', 'Dyskinesia, Drug-Induced-include-Akathisia, Drug-Induced', 'Pain Insensitivity, Congenital-improved-Pain', 'Lymphoma-suffer-Death', 'Lymphoma-suffer-Neoplasms', 'Heart Diseases-related-Substance-Related Disorders', 'Stroke-related-Substance-Related Disorders', 'Death-caused-Heart Failure, Diastolic', 'Hyperplasia-include-Myositis', 'Neoplasms-include-Myositis', 'Hearing Loss-hear-Otosclerosis', 'Hearing Loss-hear-Otitis', 'Hearing Loss-contribute-Tinnitus', 'Otosclerosis-contribute-Tinnitus', 'Otitis-contribute-Tinnitus', 'Diabetes Mellitus-predict-Diabetes Mellitus, Type 1', 'Atherosclerosis-associated-Blood Platelet Disorders', 'Blood Platelet Disorders-associated-Atherosclerosis', 'Blood Platelet Disorders-seen-Diabetes Mellitus', 'Back Pain-used-Osteoporosis', 'Pancreatitis-estimated-Pancreatic Diseases', 'Thrombosis-associated-Inflammation', 'Inflammation-associated-Thrombosis', 'Bradycardia-tend-Death', 'Cardiomyopathy, Dilated-tend-Death', 'Dementia-include-Hematoma, Subdural', 'Urinary Incontinence-include-Hematoma, Subdural', 'Paresis-include-Hematoma, Subdural', 'Dementia-include-Hydrocephalus', 'Urinary Incontinence-include-Hydrocephalus', 'Paresis-include-Hydrocephalus', 'Paroxysmal Hemicrania-receive-Headache', 'Headache-need-Arteritis', 'Headache-prevent-Blindness', 'Arteritis-prevent-Blindness', 'Headache-caused-Neoplasms', 'Headache-caused-Abscess', 'Nausea-caused-Neoplasms', 'Nausea-caused-Abscess', 'Vomiting-caused-Neoplasms', 'Headache-include-Drug-Related Side Effects and Adverse Reactions', 'Vomiting-include-Drug-Related Side Effects and Adverse Reactions', 'Vomiting-caused-Abscess', 'Hypotension-include-Drug-Related Side Effects and Adverse Reactions', 'Tachycardia-include-Drug-Related Side Effects and Adverse Reactions', 'Headache-rupture-Intracranial Aneurysm', 'Hypertension-suffer-Cardiovascular Diseases', 'Subarachnoid Hemorrhage-rupture-Intracranial Aneurysm', 'Death-notice-Breast Neoplasms', 'Breast Neoplasms-discovered-Neoplasms', 'Gastrointestinal Diseases-associated-Hemorrhage', 'Hemorrhage-associated-Gastrointestinal Diseases', 'Gastrointestinal Diseases-associated-Ulcer', 'Ulcer-associated-Gastrointestinal Diseases', 'Gastrointestinal Diseases-associated-Colonic Neoplasms', 'Colonic Neoplasms-associated-Gastrointestinal Diseases', 'Colonic Neoplasms-include-Ulcer', 'Adrenal Insufficiency-associated-Memory Disorders', 'Memory Disorders-associated-Adrenal Insufficiency', 'Cerebrovascular Disorders-associated-Memory Disorders', 'Memory Disorders-associated-Cerebrovascular Disorders', 'Central Nervous System Diseases-characterized-Headache', 'Central Nervous System Diseases-characterized-Kidney Diseases', 'Kidney Diseases-include-Drug-Related Side Effects and Adverse Reactions', 'Chemical and Drug Induced Liver Injury-include-Drug-Related Side Effects and Adverse Reactions', 'Corneal Opacity-decrease-Optic Atrophy', 'Retinal Diseases-decrease-Optic Atrophy', 'Fractures, Bone-hear-Hearing Loss', 'Cataract-decrease-Optic Atrophy', 'Myopia-observed-Retinal Degeneration', 'Myopia-observed-Cataract', 'Optic Atrophy-decrease-Diabetes Mellitus', 'Optic Atrophy-decrease-Glaucoma', 'Hearing Loss-develop-Osteoporosis', 'Optic Atrophy-decrease-Macular Degeneration', 'Neurologic Manifestations-suffer-Epilepsy', 'Acquired Immunodeficiency Syndrome-tend-Communicable Diseases', 'Acquired Immunodeficiency Syndrome-develop-Communicable Diseases', 'Death-noted-Intracranial Hypotension', 'Death-noted-Bronchopneumonia', 'Cytomegalovirus Infections-associated-Sarcoma, Kaposi', 'Sarcoma, Kaposi-associated-Cytomegalovirus Infections', 'Parkinson Disease-shift-Neurologic Manifestations', 'Parkinson Disease-shift-Brain Diseases', 'Precancerous Conditions-treat-Skin Neoplasms', 'Hypertension-assess-Hypertrophy, Left Ventricular', 'Vascular System Injuries-caused-Takotsubo Cardiomyopathy', 'Supranuclear Palsy, Progressive-accumulate-Alzheimer Disease', 'Neurologic Manifestations-lead-Coma', 'Alzheimer Disease-predispose-Delirium', 'Prostatic Neoplasms-metastasize-Neoplasm Metastasis', 'Drug-Related Side Effects and Adverse Reactions-correlated-Delirium', 'Delirium-produce-Brain Diseases, Metabolic', 'Small Cell Lung Carcinoma-associated-Drug-Related Side Effects and Adverse Reactions', 'Drug-Related Side Effects and Adverse Reactions-associated-Small Cell Lung Carcinoma', 'Death-rise-Peptic Ulcer', 'Brain Diseases-suffer-Cerebral Amyloid Angiopathy', 'Hemorrhage-caused-Cerebral Amyloid Angiopathy', 'Gallbladder Diseases-remain-Pleural Effusion', 'Gallstones-recovered-Pleural Effusion', 'Gallstones-recovered-Shock, Septic', 'Neurologic Manifestations-occur-Fractures, Bone', 'Neurologic Manifestations-occur-Wounds and Injuries', 'Intracranial Aneurysm-include-Death', 'Arthritis, Juvenile-employed-Diabetes Mellitus', 'Arthritis, Juvenile-employed-Hypertension', 'Death-increased-Infections', 'Death-tend-Diabetes Mellitus', 'Diabetes Mellitus-tend-Infections', 'Tuberculosis-suggest-Death', 'Cholecystitis, Acute-excluded-Gallbladder Diseases', 'Microstomia-correct-Cicatrix', 'Hypotension-study-Hypertension', 'Hypertrophy-study-Hypertension', 'Osteoarthritis-aggregated-Arthritis', 'Bacteremia-used-Pneumococcal Infections', 'Bacteremia-recommended-Pneumococcal Infections', 'Death-examined-Diabetes Mellitus, Type 1', 'Coronary Artery Disease-accompanied-Angina Pectoris', 'Neoplasm Metastasis-removed-Lung Neoplasms', 'Parkinson Disease-suffer-Death', 'Pneumonia-defined-Respiratory Tract Infections', 'Dementia-search-Phenylketonurias', 'Dementia-lead-Phenylketonurias', 'Infections-associated-Pulmonary Embolism', 'Pulmonary Embolism-associated-Infections', 'Oliguria-develop-Death', 'Oliguria-develop-Renal Insufficiency', 'Stenosis, Pulmonary Artery-increase-Coronary Artery Disease', 'Stenosis, Pulmonary Artery-increase-Ventricular Dysfunction, Left', 'Bacteremia-attributed-Sepsis', 'Death-confirm-Sepsis', 'Pneumonia-develop-Pulmonary Embolism', 'Gastrointestinal Hemorrhage-develop-Pulmonary Embolism', 'Death-occur-Renal Insufficiency', 'Scabies-present-Skin Diseases', 'Chronic Disease-accounted-Alzheimer Disease', 'Death-computed-Kidney Diseases', 'Diabetic Nephropathies-decrease-Death', 'Death-found-Parkinson Disease', 'Lipoid Proteinosis of Urbach and Wiethe-develop-Myalgia', 'Arrhythmias, Cardiac-related-Heterotaxy Syndrome', 'Death-fail-Parkinson Disease', 'Death-uncover-Parkinson Disease', 'Diabetes Mellitus-present-Urinary Bladder, Neurogenic', 'Urinary Incontinence-present-Urinary Bladder Diseases', 'Diabetes Mellitus-described-Nervous System Diseases', 'Epilepsy-found-Brain Neoplasms', 'Spinal Fractures-reduced-Osteoporosis', 'Sexually Transmitted Diseases-avoid-Infections', 'Prostatic Neoplasms-produce-Neoplasms', 'Prostatic Neoplasms-required-Neoplasms', 'Heart Diseases-shown-Angina Pectoris', 'Ventricular Premature Complexes-found-Hypertension', 'Ventricular Premature Complexes-show-Hypertension', 'Ventricular Premature Complexes-increased-Hypertension', 'Ventricular Premature Complexes-related-Hypertension', 'Ischemia-suffer-Stroke', 'Inflammatory Bowel Diseases-lead-Death', 'Neoplasms-behave-Colorectal Neoplasms', 'Wounds and Injuries-cause-Severe Acute Respiratory Syndrome', 'Muscular Diseases-include-Head and Neck Neoplasms', 'Anemia, Iron-Deficiency-develop-Hemorrhage', 'Dementia-differentiate-Delirium', 'Pain-involve-Arthritis, Rheumatoid', 'Ischemia-present-Necrosis', 'Xerostomia-cause-Disorders of Excessive Somnolence', 'Constipation-cause-Disorders of Excessive Somnolence', 'Leukoencephalopathies-associated-Atherosclerosis', 'Atherosclerosis-associated-Leukoencephalopathies', 'Leukoencephalopathies-associated-Arteriolosclerosis', 'Arteriolosclerosis-associated-Leukoencephalopathies', 'Babesiosis-manifested-Fever', 'Babesiosis-manifested-Anemia, Hemolytic', 'Babesiosis-manifested-Thrombocytopenia', 'Muscular Disorders, Atrophic-involve-Vision Disorders', 'Death-underlie-Diabetes Mellitus', 'Diabetes Mellitus-preceded-Cardiovascular Diseases', 'Diabetes Mellitus-preceded-Lung Diseases', 'Bacterial Infections-investigate-Disseminated Intravascular Coagulation', 'Pain-decrease-Blood Loss, Surgical', 'Pain-treat-Menorrhagia', 'Coinfection-decrease-Blood Loss, Surgical', 'Coinfection-treat-Menorrhagia', 'Erythema Multiforme-cause-Conjunctival Diseases', 'Cardiovascular Diseases-contribute-Diabetes Mellitus', 'Disease Progression-characterized-Corneal Diseases', 'Alcohol Withdrawal Seizures-including-Psychomotor Agitation', 'Alcohol Withdrawal Seizures-including-Delirium', 'Rheumatic Fever-diagnose-Pharyngeal Diseases', 'Ischemia-underlie-Aneurysm', 'Ischemia-underlie-Stroke', 'Ischemia-underlie-Myocardial Infarction', 'Ischemia-underlie-Death', 'Aneurysm-underlie-Stroke', 'Aneurysm-underlie-Myocardial Infarction', 'Aneurysm-underlie-Death', 'Cholelithiasis-account-Neoplasms', 'Cholelithiasis-account-Pancreatic Diseases', 'Neoplasms-account-Pancreatic Diseases', 'Ischemia-masquerade-Colitis', 'Ischemia-masquerade-Diverticulitis', 'Ischemia-masquerade-Neoplasms', 'Ischemia-masquerade-Inflammatory Bowel Diseases', 'Colitis-masquerade-Inflammatory Bowel Diseases', 'Diverticulitis-masquerade-Inflammatory Bowel Diseases', 'Neoplasms-masquerade-Inflammatory Bowel Diseases', 'Hypertension-shorten-Stroke', 'Hypertension-shorten-Heart Failure', 'Myocardial Infarction-less-Heart Failure', 'Inferior Wall Myocardial Infarction-demonstrate-Death', 'Ventricular Dysfunction, Left-occur-Inferior Wall Myocardial Infarction', 'Neoplasms-occur-Immunologic Deficiency Syndromes', 'Metabolic Diseases-feature-Liver Diseases', 'Genetic Diseases, Inborn-feature-Liver Diseases', 'Hypertrophy, Left Ventricular-associate-Hypotension', 'Hypotension-associate-Hypertrophy, Left Ventricular', 'Atherosclerosis-lead-Diabetes Mellitus', 'Atherosclerosis-lead-Hypertension, Renovascular', 'Polymyalgia Rheumatica-characterized-Hip Dislocation, Congenital', 'Pain-involve-Hip Dislocation, Congenital', 'Pain-characterized-Hip Dislocation, Congenital', 'Synovitis-seen-Polymyalgia Rheumatica', 'Osteoarthritis-mimic-Polymyalgia Rheumatica', 'Muscular Diseases-mimic-Polymyalgia Rheumatica', 'Fibromyalgia-mimic-Polymyalgia Rheumatica', 'Infections-separate-Polymyalgia Rheumatica', 'Polymyalgia Rheumatica-differentiate-Arthritis, Rheumatoid', 'Polymyalgia Rheumatica-underlie-Arteritis', 'Venous Thrombosis-include-Ulcer', 'Aneurysm-include-Ulcer', 'Diabetes Mellitus-include-Ulcer', 'Chronic Disease-underlie-Infections', 'Chronic Disease-underlie-Sepsis', 'Delirium-cause-Infections', 'Communicable Diseases-precipitate-Delirium', 'Neoplasms-differ-Carcinoma, Squamous Cell', 'Immunologic Deficiency Syndromes-determine-Xeroderma Pigmentosum', 'Hypothyroidism-considered-Thyroiditis, Autoimmune', 'Hypothyroidism-evidence-Thyroiditis, Autoimmune', 'Xeroderma Pigmentosum-include-Hyperkeratosis, Epidermolytic', 'Xeroderma Pigmentosum-include-Neoplasms', 'Xeroderma Pigmentosum-include-Melanoma', 'Melanoma-include-Hyperkeratosis, Epidermolytic', 'Alzheimer Disease-recognized-Dementia', 'Kidney Diseases-provide-Kidney Failure, Chronic', 'Renal Insufficiency-attributed-Diabetic Nephropathies', 'Stroke-occur-Nephrotic Syndrome', 'Malnutrition-result-Chronic Disease', 'Hypertension-induce-Cardiomyopathy, Hypertrophic', 'Death-occur-Aortic Aneurysm', 'Death-occur-Nephrotic Syndrome', 'Respiratory Tract Diseases-develop-Alveolitis, Extrinsic Allergic', 'Respiratory Tract Diseases-provoke-Asthma', 'Respiratory Tract Diseases-develop-Drug Hypersensitivity', 'Alveolitis, Extrinsic Allergic-provoke-Asthma', 'Drug Hypersensitivity-provoke-Asthma', 'Intestinal Diseases-include-Ischemia', 'Atherosclerosis-include-Ischemia', 'Neuromuscular Diseases-estimated-Lung Neoplasms', 'Pulmonary Embolism-result-Death', 'Lung Neoplasms-develop-Pulmonary Fibrosis', 'Lung Neoplasms-associated-Pulmonary Fibrosis', 'Pulmonary Fibrosis-associated-Lung Neoplasms', 'Lung Neoplasms-suspected-Pulmonary Fibrosis', 'Lung Neoplasms-suspected-Neoplasms', 'Pulmonary Fibrosis-suspected-Neoplasms', 'Death-cause-Small Cell Lung Carcinoma', 'Osteoarthritis-show-Inflammation', 'Arthritis, Rheumatoid-compare-Osteoarthritis', 'Arthritis, Psoriatic-associate-Osteoarthritis', 'Osteoarthritis-associate-Arthritis, Psoriatic', 'Alzheimer Disease-assigned-Dementia, Vascular', 'Alzheimer Disease-assigned-Ischemia', 'Dementia, Vascular-assigned-Ischemia', 'Fractures, Bone-shown-Hip Fractures', 'Back Pain-investigated-Hip Fractures', 'Back Pain-related-Osteoporosis', 'Sleep Initiation and Maintenance Disorders-include-Immunologic Deficiency Syndromes', 'Thyroiditis, Autoimmune-associated-Hypothyroidism', 'Hypothyroidism-associated-Thyroiditis, Autoimmune', 'Eye Abnormalities-undertaken-Intellectual Disability', 'Anophthalmos-include-Eye Abnormalities', 'Atherosclerosis-produce-Bacteremia', 'Chemical and Drug Induced Liver Injury-suspected-Abdominal Pain', 'Chemical and Drug Induced Liver Injury-suspected-Fever', 'Chemical and Drug Induced Liver Injury-suspected-Cholestasis', 'Glioma-derived-Neoplasms', 'Death-attributed-Heart Diseases', 'Memory Disorders-categorized-Alzheimer Disease', 'Memory Disorders-categorized-Ischemia', 'Dementia-categorized-Alzheimer Disease', 'Dementia-categorized-Ischemia', 'Cerebrovascular Disorders-increased-Memory Disorders', 'Cerebrovascular Disorders-increased-Dementia', 'Hypertension-become-Cardiovascular Diseases', 'Korsakoff Syndrome-associated-Hypothalamic Diseases', 'Hypothalamic Diseases-associated-Korsakoff Syndrome', 'Amnesia-contribute-Memory Disorders', 'Amnesia-associated-Hypothalamic Diseases', 'Hypothalamic Diseases-associated-Amnesia', 'Death-fell-Ulcer', 'Ataxia-disappear-Neoplasms', 'Nystagmus, Pathologic-disappear-Neoplasms', 'Neoplasms-performed-Headache Disorders, Secondary', 'Adenocarcinoma-account-Cystadenocarcinoma', 'Neoplasms-improve-Headache Disorders, Secondary', 'Neoplasms-account-Cystadenocarcinoma', 'Parkinsonian Disorders-appear-Nerve Degeneration', 'Parkinsonian Disorders-appear-Parkinson Disease', 'Vasospasm, Intracranial-lead-Subarachnoid Hemorrhage', 'Language Disorders-examined-Alzheimer Disease', 'Arteritis-receive-Malformations of Cortical Development', 'Vasculitis-receive-Malformations of Cortical Development', 'Delirium-produce-Headache', 'Delirium-produce-Vision Disorders', 'Serositis-associated-Lupus Erythematosus, Systemic', 'Lupus Erythematosus, Systemic-associated-Serositis', 'Lung Diseases-associated-Lupus Erythematosus, Systemic', 'Lupus Erythematosus, Systemic-associated-Lung Diseases', "Sjogren's Syndrome-associated-Lupus Erythematosus, Systemic", "Lupus Erythematosus, Systemic-associated-Sjogren's Syndrome", 'Tuberculosis-accounted-Immunologic Deficiency Syndromes', 'Lupus Erythematosus, Systemic-associated-Raynaud Disease', 'Raynaud Disease-associated-Lupus Erythematosus, Systemic', 'Lupus Erythematosus, Systemic-associated-Fever', 'Fever-associated-Lupus Erythematosus, Systemic', 'Lupus Erythematosus, Systemic-associated-Lymphatic Diseases', 'Lymphatic Diseases-associated-Lupus Erythematosus, Systemic', 'Thrombosis-occur-Hemorrhage', 'Pain-tend-Gastrointestinal Hemorrhage', 'Severe Dengue-develop-Death', 'Neoplasms-arise-Hypertrophy', 'Neoplasms-arise-Hyperplasia', 'Carcinogenesis-precede-Genetic Diseases, Inborn', 'Genetic Diseases, Inborn-occur-Carcinogenesis', 'Hypertension, Renovascular-corrected-Death', 'Coronary Artery Disease-exist-Hypertension', 'Renal Insufficiency-exist-Hypertension', 'Periodontal Diseases-represent-Tooth Loss', 'Pneumonia-recognized-Infections', 'Hypotension, Orthostatic-precipitate-Fractures, Bone', 'Hypotension, Orthostatic-precipitate-Myocardial Infarction', 'Hypotension, Orthostatic-precipitate-Stroke', 'Arrhythmias, Cardiac-include-Nervous System Diseases', 'Acute Disease-include-Nervous System Diseases', 'Infections-include-Nervous System Diseases', 'Heart Failure-include-Nervous System Diseases', 'Hypotension, Orthostatic-defined-Brain Ischemia', 'Gastrointestinal Hemorrhage-include-Nervous System Diseases', 'Hypotension-show-Death', 'Immunologic Deficiency Syndromes-develop-Infections', 'Stroke-consider-Endocarditis', 'Ischemia-consider-Endocarditis', 'Brain Diseases-consider-Endocarditis', 'Meningitis-consider-Endocarditis', 'Brain Abscess-consider-Endocarditis', 'Vision Disorders-consider-Endocarditis', 'Seizures-consider-Endocarditis', 'Headache-consider-Endocarditis', 'Back Pain-consider-Endocarditis', 'Mononeuropathies-consider-Endocarditis', 'Constipation-associated-Death', 'Death-associated-Constipation', 'Necrosis-distinguish-Neoplasms', 'Neoplasms-differentiate-Edema', 'Epilepsy-localize-Seizures', 'Obesity-considered-Tachycardia', 'Obesity-considered-Hypotension', 'Obesity-considered-Fever', 'Hyperopia-found-Myopia', 'Hyperparathyroidism, Secondary-contribute-Hip Fractures', 'Dyskinesia, Drug-Induced-considered-Respiratory Insufficiency', 'Dyskinesia, Drug-Induced-develop-Movement Disorders', 'Death-occur-Proteinuria', 'Proteinuria-occur-Death', 'Proteinuria-occur-Cardiovascular Diseases', 'Proteinuria-occur-Diabetes Mellitus, Type 1', 'Renal Insufficiency-occur-Diabetes Mellitus, Type 1', 'Diabetic Nephropathies-account-Death', 'Diabetic Nephropathies-afflicted-Diabetes Mellitus', 'Death-diagnosed-Lung Diseases', 'Infarction, Posterior Cerebral Artery-associated-Atrial Fibrillation', 'Atrial Fibrillation-associated-Infarction, Posterior Cerebral Artery', 'Infarction, Posterior Cerebral Artery-seen-Stroke', 'Atrial Fibrillation-seen-Stroke', 'Fractures, Bone-appear-Bone Neoplasms', 'Infarction, Posterior Cerebral Artery-associated-Heart Diseases', 'Heart Diseases-associated-Infarction, Posterior Cerebral Artery', 'Infarction, Posterior Cerebral Artery-seen-Thrombosis', 'Heart Diseases-seen-Thrombosis', 'Atrial Fibrillation-seen-Thrombosis', 'Headache-associated-Joint Diseases', 'Joint Diseases-associated-Headache', 'Colorectal Neoplasms-disguised-Appendicitis', 'Headache-experience-Migraine Disorders', 'Headache-experience-Nausea', 'Headache-experience-Vomiting', 'Migraine Disorders-experience-Nausea', 'Migraine Disorders-experience-Vomiting', 'Appendicitis-rule-Neoplasms', 'Neoplasms-give-Stomach Neoplasms', 'Death-examined-Myocardial Infarction', 'Hemorrhage-examined-Myocardial Infarction', 'Blister-prove-Neoplasms', 'Coronary Artery Disease-select-Death', 'Blister-detected-Neoplasms', 'Dysentery-account-Death', 'Urinary Incontinence-cause-Constipation', 'Airway Obstruction-overlooked-Heart Failure', 'Corneal Diseases-accelerate-Ulcer', 'Stroke-predispose-Atrial Fibrillation', 'Pigmentation Disorders-lost-Parkinson Disease', 'Lymphoma, Non-Hodgkin-remain-Drug-Related Side Effects and Adverse Reactions', 'Hypertrophy, Left Ventricular-increase-Hypertension', 'Hypertrophy, Left Ventricular-increase-Obesity', 'Hypertrophy, Left Ventricular-increase-Diabetes Mellitus', 'Arrhythmias, Cardiac-include-Respiratory Insufficiency', 'Arrhythmias, Cardiac-include-Neurologic Manifestations', 'Cardiomyopathy, Hypertrophic-increase-Death', 'Cardiomyopathy, Hypertrophic-increase-Hypertension', 'Cardiomyopathy, Hypertrophic-increase-Obesity', 'Cardiomyopathy, Hypertrophic-increase-Diabetes Mellitus', 'Ventricular Septal Rupture-occur-Myocardial Infarction', 'Heart Failure-fall-Ventricular Septal Rupture', 'Myocardial Infarction-develop-Ventricular Septal Rupture', 'Inferior Wall Myocardial Infarction-develop-Ventricular Septal Rupture', 'Pasteurella Infections-treated-Infections', 'Psychomotor Disorders-performed-Diabetes Mellitus', 'Diabetes Mellitus-perform-Psychomotor Disorders', 'Erectile Dysfunction-associated-Urinary Incontinence', 'Urinary Incontinence-associated-Erectile Dysfunction', 'Osteoporosis-include-Pigmentation Disorders', 'Kidney Tubular Necrosis, Acute-found-Acute Kidney Injury', 'Heart Failure-include-Cardiotoxicity', 'Myocardial Infarction-reduce-Heart Failure', 'Trachoma-considered-Blindness', 'Trachoma-develop-Blindness', 'Lung Diseases-associated-Weight Loss', 'Weight Loss-associated-Lung Diseases', 'Lung Diseases-associated-Cachexia', 'Cachexia-associated-Lung Diseases', 'Lung Diseases-associated-Dehydration', 'Dehydration-associated-Lung Diseases', 'Muscle Weakness-cause-Hyperalgesia', 'Muscle Weakness-cause-Nervous System Diseases', 'Alcoholic Korsakoff Syndrome-compromised-Alcoholism', 'Drug-Related Side Effects and Adverse Reactions-contribute-Kidney Diseases', 'Takotsubo Cardiomyopathy-evaluate-Aortic Valve Stenosis', 'Aortic Valve Stenosis-undergo-Takotsubo Cardiomyopathy', 'Kidney Failure, Chronic-associated-Brain Diseases', 'Brain Diseases-associated-Kidney Failure, Chronic', 'Chronic Kidney Disease-Mineral and Bone Disorder-associated-Brain Diseases', 'Brain Diseases-associated-Chronic Kidney Disease-Mineral and Bone Disorder', 'Hypotension-shown-Hypertension', 'Stomach Neoplasms-associated-Gastritis, Atrophic', 'Gastritis, Atrophic-associated-Stomach Neoplasms', 'Bone Neoplasms-prevent-Hyperparathyroidism, Secondary', 'Ulcer-reveal-Hemorrhage', 'Nerve Degeneration-associated-Plaque, Amyloid', 'Plaque, Amyloid-associated-Nerve Degeneration', 'Epstein-Barr Virus Infections-found-Atherosclerosis', 'Epstein-Barr Virus Infections-occur-Atherosclerosis', 'Infections-occur-Atherosclerosis', 'Atherosclerosis-reactivate-Infections', 'Gastrointestinal Diseases-followed-Pruritus', 'Lymphoproliferative Disorders-receive-Lymphoma', 'Sarcoma, Kaposi-receive-Lymphoma', 'Heart Failure-report-Kidney Failure, Chronic', 'Thrombosis-noted-Diabetes Mellitus', 'Infections-noted-Diabetes Mellitus', 'Cardiovascular Diseases-found-Diabetes Mellitus', 'Cardiovascular Diseases-found-Brugada Syndrome', 'Cardiovascular Diseases-found-Hypertension', 'Amnesia-provide-Cataract', 'Amnesia-provide-Ocular Hypertension', 'Death-survive-Heart Arrest', 'Death-survive-Tachycardia, Ventricular', 'Death-survive-Ventricular Fibrillation', 'Heart Arrest-survive-Tachycardia, Ventricular', 'Headache Disorders, Primary-considered-Headache', 'Heart Arrest-survive-Ventricular Fibrillation', 'Hearing Loss-influence-Kidney Failure, Chronic', 'Hearing Disorders-hear-Hearing Loss, Central', 'Tinnitus-correlate-Hearing Loss', 'Ear Diseases-hear-Deafness', 'Alzheimer Disease-characterized-Brain Diseases', 'Muscular Disorders, Atrophic-corrected-Atrophy', 'Dyspnea-show-Heart Failure', 'Myocardial Infarction-shown-Dyspnea', 'Dyspnea-show-Lung Diseases', 'Myocardial Infarction-occur-Chest Pain', 'Dyspnea-occur-Chest Pain', 'Peritoneal Neoplasms-observed-Abdominal Pain', 'Peritoneal Neoplasms-guard-Muscle Rigidity', 'Abdominal Pain-guard-Muscle Rigidity', 'Bone Resorption-cause-Osteoporosis', 'Bone Neoplasms-cause-Osteoporosis', 'Hypertension-characterized-Hypotension, Orthostatic', 'Prostatitis-compared-Prostatic Hyperplasia', 'Genetic Diseases, Inborn-resemble-Huntington Disease', 'Abetalipoproteinemia-resemble-Huntington Disease', 'Neuroacanthocytosis-resemble-Huntington Disease', 'Neurologic Manifestations-related-Hyperglycemia', 'Neoplasms-determined-Neoplasm Metastasis', 'Urinary Incontinence-result-Bacteriuria', 'Pressure Ulcer-result-Bacteriuria', 'Cardiomyopathy, Hypertrophic-compare-Cardiomyopathies', 'Hypertension-compare-Cardiomyopathies', 'Hypertension-make-Hypertrophy', 'Hypertension-make-Cardiomyopathies', 'Hypertrophy-make-Cardiomyopathies', 'Constriction, Pathologic-produced-Rheumatic Fever', 'Mitral Valve Insufficiency-found-Mitral Valve Stenosis', 'Hypertrophy-show-Mitral Valve Stenosis', 'Neoplasms-cause-Heart Failure', 'Heart Failure-cause-Adenoma', 'Dementia-related-Sleep Apnea Syndromes', 'Polyps-found-Adenoma', 'Periodontitis-affect-Tooth Loss', 'Periodontitis-affect-Periodontal Diseases', 'Aphasia-progress-Dementia', 'Aphasia-develop-Alzheimer Disease', 'Ventricular Dysfunction, Left-predict-Death', 'Aphasia-elucidate-Alzheimer Disease', 'Death-occur-Cardiac Output, Low', 'Death-influenced-Postoperative Hemorrhage', 'Death-influenced-Ischemia', 'Hemorrhage-related-Hemostatic Disorders', 'Hemorrhage-complicated-Hemostatic Disorders', 'Hemostatic Disorders-related-Kidney Diseases', 'Hemostatic Disorders-related-Coinfection', 'Hemostatic Disorders-complicated-Coinfection', 'Death-occur-Ventricular Dysfunction, Left', 'Hemostatic Disorders-associated-Kidney Diseases', 'Kidney Diseases-associated-Hemostatic Disorders', 'Hypertension-appear-Ovarian Diseases', 'Death-include-Mitral Valve Stenosis', 'Mitral Valve Stenosis-undergo-Death', 'Periodontal Diseases-develop-Calculi', 'Hemorrhage-attributed-Dilatation, Pathologic', 'Hypertension-revised-Heart Failure', 'Brain Injuries, Diffuse-point-Hypoxia, Brain', 'Dementia-point-Dementia, Vascular', 'Hypertension, Renovascular-undergo-Vestibulocochlear Nerve Injuries', 'Infections-suffer-Death', 'Dementia-point-Hypoxia, Brain', 'Dementia-point-Brain Diseases', 'Dementia, Vascular-point-Hypoxia, Brain', 'Dementia, Vascular-point-Brain Diseases', 'Wounds and Injuries-caused-Acute Disease', 'Werner Syndrome-characterized-Growth Disorders', 'Osteosclerosis-combine-Osteoporosis', 'Osteoporosis-suggest-Werner Syndrome', 'Iatrogenic Disease-ruled-Signs and Symptoms, Digestive', 'Craniocerebral Trauma-based-Coma', 'Wounds and Injuries-predict-Craniocerebral Trauma', 'Infections-occur-IgA Vasculitis', 'Pulmonary Disease, Chronic Obstructive-associated-Bronchopneumonia', 'Bronchopneumonia-associated-Pulmonary Disease, Chronic Obstructive', 'Pulmonary Disease, Chronic Obstructive-associated-Pulmonary Embolism', 'Pulmonary Embolism-associated-Pulmonary Disease, Chronic Obstructive', 'Myocardial Infarction-associated-Pulmonary Embolism', 'Pulmonary Embolism-associated-Myocardial Infarction', 'Death-find-Fat Necrosis', 'Memory Disorders-confused-Dementia', 'Pneumonia-defined-Cough', 'Pneumonia-defined-Fever', 'Pneumonia-defined-Dyspnea', 'Stroke-associated-Hypertension, Malignant', 'Hypertension, Malignant-associated-Stroke', 'Hypertension-shifted-Hypotension', 'Edema-shorten-Atrophy', 'Pancreatitis-torn-Wounds, Nonpenetrating', 'Pancreatitis-occur-Wounds, Nonpenetrating', 'Hypothermia-underlie-Hypoproteinemia', 'Hypothermia-underlie-Cachexia', 'Hypothermia-treated-Sepsis', 'Leukocytosis-noted-Neutropenia', 'Tuberculosis-observed-Weight Loss', 'Death-predict-Cardiovascular Diseases', 'Cough-observed-Weight Loss', 'Fever-observed-Weight Loss', 'Myocardial Infarction-followed-Death', 'Acute Kidney Injury-develop-Glomerulonephritis', 'Acute Kidney Injury-develop-Nephrotic Syndrome', 'Myocardial Infarction-evaluate-Death, Sudden', 'Death-associated-Death, Sudden', 'Death, Sudden-associated-Death', 'Leukoencephalopathies-suffer-Dementia, Vascular', 'Dementia-reveal-Leukoencephalopathies', 'Hypertension-suffer-Dementia, Vascular', 'Hyperkalemia-occur-Diabetes Mellitus', 'Hyperkalemia-develop-Diabetes Mellitus', 'Hypokalemic Periodic Paralysis-corrected-Hypokalemia', 'Hypokalemic Periodic Paralysis-occur-Hyperkalemia', 'Hypokalemia-occur-Hyperkalemia', 'Vision Disorders-consider-Death', 'Vision Disorders-need-Dementia', 'Pain-employ-Headache', 'Pain-assess-Headache', 'Headache-begin-Pain', 'Drug Hypersensitivity-result-Fatigue', 'Drug Hypersensitivity-result-Sleep Initiation and Maintenance Disorders', 'Rheumatic Fever-appear-Calcinosis', 'Death-repaired-Hernia', 'Death-recommended-Wounds and Injuries', 'Fever-predict-Infections', 'Leukocytosis-predict-Infections', 'Fever-assessed-Bacterial Infections', 'Leukocytosis-assessed-Bacterial Infections', 'Hip Fractures-include-Wounds and Injuries', 'Vision Disorders-contribute-Cardiac Output, Low', 'Vision Disorders-contribute-Fractures, Bone', 'Heart Diseases-associated-Ventricular Premature Complexes', 'Ventricular Premature Complexes-associated-Heart Diseases', 'Cardiovascular Diseases-ranked-Death', 'Colonic Pseudo-Obstruction-overtake-Neoplasms', 'Dyspepsia-associated-Arthritis', 'Arthritis-associated-Dyspepsia', 'Infections-include-Pregnancy Complications, Infectious', 'Infections-detect-Tuberculosis', 'Fractures, Bone-predispose-Bone Neoplasms', 'Colorectal Neoplasms-contribute-Urinary Incontinence', 'Pain Insensitivity, Congenital-used-Headache', 'Esophageal Achalasia-treated-Cardiomyopathy, Dilated', 'Chronic Disease-treated-Cardiomyopathy, Dilated', 'Gastroesophageal Reflux-heal-Gastrointestinal Diseases', 'Diabetes Mellitus-faced-Infections', 'Neoplasms-behave-Hematologic Neoplasms', 'Sleep Initiation and Maintenance Disorders-tolerate-Sleep Wake Disorders', 'Thrombosis-involve-Constriction, Pathologic', 'Thrombosis-indicated-Infarction', 'Erectile Dysfunction-cause-Sensation Disorders', 'Neoplasms-associated-Parotid Neoplasms', 'Parotid Neoplasms-associated-Neoplasms', 'Sebaceous Gland Neoplasms-account-Eyelid Diseases', 'Hypotension-related-Pulmonary Embolism', 'Heart Arrest-related-Pulmonary Embolism', 'Stroke-subdivided-Rhabdomyolysis', 'Hematoma-result-Wounds and Injuries', 'Coronary Artery Disease-bring-Hypercholesterolemia', 'Hypertension-combined-Hyperlipidemias', 'Hypertrophy, Left Ventricular-contribute-Cardiac Complexes, Premature', 'Dyslipidemias-reduce-Death', 'Tachycardia-detect-Sick Sinus Syndrome', 'Immunologic Deficiency Syndromes-linked-Carcinogenesis', 'Immunologic Deficiency Syndromes-linked-Nerve Degeneration', 'Death-seen-Tricuspid Atresia', 'Meningitis-include-Central Nervous System Infections', 'Empyema, Subdural-include-Central Nervous System Infections', 'Epidural Abscess-include-Central Nervous System Infections', 'Meningitis-occur-Infections', 'Infarction, Middle Cerebral Artery-reduce-Neurologic Manifestations', 'Infarction, Middle Cerebral Artery-reduce-Hypertension', 'Infarction, Middle Cerebral Artery-reduce-Edema', 'Neurologic Manifestations-reduce-Hypertension', 'Neurologic Manifestations-reduce-Edema', 'Brain Ischemia-include-Neurodegenerative Diseases', 'Brain Ischemia-appear-Epilepsy', 'Cardiovascular Diseases-progress-Cardiac Output, Low', 'Heart Diseases-observed-Hypertrophy', 'Heart Diseases-observed-Coronary Artery Disease', 'Hypertension-observed-Nephrosclerosis', 'Hypertension-observed-Cerebrovascular Disorders', 'Heart Failure-represent-Neurodegenerative Diseases', 'Hypertrophy, Left Ventricular-lead-Heart Failure', 'Brain Diseases-occur-Extranodal Extension', 'Brain Diseases-occur-Hypotension', 'Autoimmune Diseases-associated-Facial Pain', 'Facial Pain-associated-Autoimmune Diseases', 'Osteoporosis-reduce-Osteoporotic Fractures', 'Cartilage Diseases-serve-Osteoarthritis', 'Osteoporosis-increase-Ovarian Neoplasms', 'Peptic Ulcer-occur-Hemorrhage', 'Otitis Externa-afflict-Diabetes Mellitus', 'Infections-afflict-Diabetes Mellitus', 'Cardiac Output, Low-interact-Osteoporosis', 'Dementia-associated-Acute Disease', 'Acute Disease-associated-Dementia', 'Osteoporosis-produce-Fractures, Bone', 'Hyperthyroidism-distinguish-Hypothyroidism', 'Inflammation-characterized-Pancreatitis', 'Fractures, Bone-render-Osteoporotic Fractures', 'Myocardial Infarction-correlated-Infarction', 'Hypertension-classified-Cardiovascular Diseases', 'Hypertension-accord-Death', 'Hypertension-accord-Cardiovascular Diseases', 'Hypertension-determine-Arrhythmias, Cardiac', 'Arrhythmias, Cardiac-determine-Ventricular Premature Complexes', 'Hypertension-induce-Arrhythmias, Cardiac', 'Tachycardia, Supraventricular-reduce-Arrhythmias, Cardiac', 'Sepsis-account-Death', 'Multiple Organ Failure-account-Death', 'Breast Neoplasms-carry-Ataxia Telangiectasia', 'Hypotension, Orthostatic-underlie-Heart Failure', 'Neoplasms-carry-Ataxia Telangiectasia', 'Heart Failure-underlie-Parkinson Disease, Secondary', 'Heart Failure-underlie-Diabetes Mellitus', 'Fibromyalgia-include-Musculoskeletal Pain', 'Myalgia-include-Fibromyalgia', 'Edema-include-Fibromyalgia', 'Musculoskeletal Pain-include-Myalgia', 'Musculoskeletal Pain-include-Fatigue', 'Rhabdomyosarcoma-carry-Sarcoma', 'Constriction, Pathologic-tolerated-Ischemia', 'Hypertension-tolerated-Ischemia', 'Alcoholism-estimated-Substance-Related Disorders', 'Infarction-scattered-Atherosclerosis', 'Infarction-involve-Atherosclerosis', 'Stroke-related-Constriction, Pathologic', 'Carotid Artery Diseases-related-Constriction, Pathologic', 'Ventricular Premature Complexes-increase-Death', 'Folic Acid Deficiency-complicated-Thrombocytopenia', 'Anemia, Megaloblastic-complicated-Thrombocytopenia', 'Death-offer-Hemophilia A', 'Coronary Artery Disease-offer-Hemophilia A', 'Diabetes Mellitus-remain-Coronary Artery Disease', 'Anemia-suggest-Postpartum Hemorrhage', 'Anemia-suggest-Hemolysis', 'Heart Arrest-demonstrate-Ventricular Fibrillation', 'Neoplasms-consider-Sleep Apnea, Obstructive', 'Hypotension, Orthostatic-eliminate-Stroke', 'Hypotension, Orthostatic-caused-Diabetes Mellitus', 'Hypotension, Orthostatic-caused-Coronary Artery Disease', 'Hypotension, Orthostatic-caused-Hypertension', 'Head and Neck Neoplasms-rule-Meningitis', 'Lethargy-attributed-Wounds and Injuries', 'Lethargy-attributed-Pain', 'Meningitis, Pneumococcal-suffer-Brain Damage, Chronic', 'Hemostatic Disorders-investigated-Venous Thromboembolism', 'Communicable Diseases-result-Hemorrhage', 'Thrombosis-compared-Acute Pain', 'Erectile Dysfunction-associated-Glucose Intolerance', 'Glucose Intolerance-associated-Erectile Dysfunction', 'Death-assessed-Thyroid Neoplasms', 'Heart Diseases-confused-Amyloidosis', 'Drug-Related Side Effects and Adverse Reactions-devised-Lymphoma, Non-Hodgkin', 'Taste Disorders-identify-Craniocerebral Trauma', 'Taste Disorders-identify-Respiratory Tract Infections', 'Cleft Palate-identify-Craniocerebral Trauma', 'Cleft Palate-identify-Respiratory Tract Infections', 'Consciousness Disorders-associated-Death', 'Death-associated-Consciousness Disorders', 'Parkinson Disease-characterized-Cardiovascular Abnormalities', 'Atrophy-characterized-Cardiovascular Abnormalities', 'Pantothenate Kinase-Associated Neurodegeneration-characterized-Cardiovascular Abnormalities', 'Alzheimer Disease-considered-Death', 'Hypertension-characterized-Cardiac Output, Low', 'Pelvic Neoplasms-lead-Thromboembolism', 'Wounds and Injuries-lead-Thromboembolism', 'Carcinogenesis-cause-Inflammation', 'Dehydration-cause-Kidney Diseases', 'Cerebral Palsy-undergo-Hyperkinesis', 'Osteoporosis-diagnosed-Hyperparathyroidism', 'Acute Pain-prevent-Neuralgia', 'Gastritis-deteriorate-Stomach Ulcer', 'Gastritis-deteriorate-Ulcer', 'Ulcer-improve-Gastritis', 'Gastritis-associated-Duodenal Ulcer', 'Duodenal Ulcer-associated-Gastritis', 'Gastritis-include-Anemia', 'Gastritis-include-Stomach Neoplasms', 'Infections-associated-Xerostomia', 'Xerostomia-associated-Infections', 'Dysgeusia-associated-Xerostomia', 'Xerostomia-associated-Dysgeusia', 'Chemical and Drug Induced Liver Injury-present-Cholestasis', 'Death-yield-Neoplasms', 'Pain, Postoperative-increased-Pain', 'Osteoarthritis-study-Pain', 'Airway Obstruction-caused-Plaque, Atherosclerotic', 'Hypertension-require-Death', 'Aneurysm-occur-Atherosclerosis', 'Arthritis-co-occur-Cerebrovascular Disorders', 'Arthritis-co-occur-Hip Fractures', 'Osteoporosis-co-occur-Cerebrovascular Disorders', 'Osteoporosis-co-occur-Hip Fractures', 'Acquired Immunodeficiency Syndrome-present-Dementia', 'HIV Infections-develop-Acquired Immunodeficiency Syndrome', 'Nervous System Diseases-associated-Acquired Immunodeficiency Syndrome', 'Acquired Immunodeficiency Syndrome-associated-Nervous System Diseases', 'Diabetes Mellitus-related-Arteriosclerosis', 'Huntington Disease-associated-Alzheimer Disease', 'Alzheimer Disease-associated-Huntington Disease', 'Alzheimer Disease-reveal-Disease Susceptibility', 'Hepatitis B-occur-Chemical and Drug Induced Liver Injury', 'Sleep Apnea Syndromes-cause-Neuroendocrine Tumors', 'Neuroendocrine Tumors-related-Sleep Apnea Syndromes', 'Death-treat-Neoplasms', 'Death-published-Cardiovascular Diseases', 'Fractures, Bone-caused-Bone Diseases, Metabolic', 'Cerebrovascular Disorders-contribute-Parkinson Disease, Secondary', 'Dysuria-involve-Prostatic Hyperplasia', 'Cerebral Arterial Diseases-associated-Arteriosclerosis', 'Arteriosclerosis-associated-Cerebral Arterial Diseases', 'Prostatic Hyperplasia-involve-Dysuria', 'Prostatic Hyperplasia-develop-Dysuria', 'Death-attributed-Drug-Related Side Effects and Adverse Reactions', 'Neoplasms-attributed-Drug-Related Side Effects and Adverse Reactions', 'Lymphoma, Non-Hodgkin-decrease-Death', 'Ulcer-measure-Death', 'Cholangitis, Sclerosing-become-Cholecystitis, Acute', 'Infections-occur-Pneumonia', 'Fatigue-consist-Tetany', 'Death-occur-Agranulocytosis', 'Death-show-Heart Failure', 'Coronary Artery Disease-increase-Pneumonia', 'Coronary Artery Disease-increase-Neoplasms', 'Aortic Aneurysm-caused-Aneurysm', 'Aortic Aneurysm-consist-Aortic Aneurysm, Abdominal', 'Aortic Aneurysm-consist-Aortic Aneurysm, Thoracic', 'Aortic Aneurysm-exist-Multiple Organ Failure', 'Arthritis, Infectious-considered-Pleural Effusion', 'Neurotoxicity Syndromes-become-Parkinson Disease', 'Alzheimer Disease-produce-Movement Disorders', 'Crush Injuries-associated-Osteoporosis', 'Osteoporosis-associated-Crush Injuries', 'Death-managed-Renal Insufficiency', 'Cross Infection-predispose-Infections', 'Arthritis-differentiated-Osteoarthritis', 'Pancreatitis-analysed-Death', 'Neoplasm Metastasis-experience-Dyspnea', 'Death-show-Colorectal Neoplasms', 'Pneumonia-give-End Stage Liver Disease', 'Death-result-Venous Thromboembolism', 'Kidney Diseases-assessed-Diabetes Mellitus', 'Proteinuria-identify-Hypotension', 'Diabetes Mellitus, Type 2-identify-Hypotension', 'Death-reported-Heart Diseases', 'Heart Diseases-precipitate-Heart Failure', 'Pain Insensitivity, Congenital-recommended-Hypertension', 'Pain Insensitivity, Congenital-recommended-Diabetes Mellitus', 'Pain Insensitivity, Congenital-recommended-Coronary Artery Disease', 'Sexual Dysfunction, Physiological-related-Diabetes Mellitus', 'Sexual Dysfunction, Physiological-find-Diabetes Mellitus', 'Sexual Dysfunction, Physiological-related-Urinary Incontinence', 'Sexual Dysfunction, Physiological-find-Urinary Incontinence', 'Colonic Neoplasms-undergo-Appendicitis', 'Neoplasms-undergo-Appendicitis', 'Neoplasms-masquerade-Appendicitis', 'Myocardial Infarction-considered-Death', 'Anemia-referred-Tics', 'Anemia-referred-Abdominal Pain', 'Duodenitis-occur-Hernia, Hiatal', 'Neoplasms-performed-Thyroid Neoplasms', 'Pneumonia-progress-Respiratory Distress Syndrome', 'Pneumonia-reveal-Coinfection', 'Cerebrovascular Disorders-compared-Death', 'Death-differ-Coronary Artery Disease', 'Cerebrovascular Disorders-remain-Death', 'Death-regarded-Ulcer', 'Ulcer-regarded-Peptic Ulcer', 'Death-regarded-Peptic Ulcer', 'Death-followed-Vasospasm, Intracranial', 'Aneurysm, Ruptured-followed-Vasospasm, Intracranial', 'Parkinson Disease-noted-Dementia', 'Chorea-resolved-Hyperthyroidism', 'Stomach Neoplasms-go-Anastomotic Leak', 'Dehydration-characterized-Chronic Disease', 'Colorectal Neoplasms-studied-Constipation', 'Radiation Pneumonitis-evaluated-Lung Neoplasms', 'Atrioventricular Block-joine-Fibrosis', 'Bradycardia-block-Death', 'Hypertension-result-Metabolic Diseases', 'Diabetes Mellitus-result-Metabolic Diseases', 'Malnutrition-fall-Cardiac Output, Low', 'Malnutrition-shed-Infections', 'Cardiac Output, Low-shed-Infections', 'Cardiac Output, Low-fall-Infections', 'Hypertension-appear-Death', 'Bacteriuria-appear-Neoplasms', 'Hyperthyroidism-characterized-Anorexia', 'Hyperthyroidism-characterized-Constipation', 'Vasculitis-considered-Mastocytosis, Systemic', 'Kidney Diseases-related-Diabetes Mellitus', 'Hypertension-confirmed-Stroke', 'Diabetic Nephropathies-assumed-Proteinuria', 'Atrophy-rule-Breast Neoplasms', 'Infarction-reveal-Gliosis', 'Infarction-reveal-Demyelinating Diseases', 'Infarction-distinguish-Gliosis', 'Infarction-distinguish-Demyelinating Diseases', 'Serositis-decrease-Cardiac Output, Low', "Sjogren's Syndrome-decrease-Cardiac Output, Low", 'Dilatation, Pathologic-develop-Arteritis', 'Death-related-Calculi', 'Leukocyte Disorders-contribute-Infections', 'Leukocyte Disorders-contribute-Diabetes Mellitus', 'Death-analysed-Stroke', 'Death-analysed-Coronary Artery Disease', 'Hypertension-found-Death', 'Tuberculosis-discovered-Death', 'Hypothermia-evaluated-Blood Coagulation Disorders', 'Hypothermia-contribute-Blood Coagulation Disorders', 'Lupus Erythematosus, Systemic-affected-Drug Hypersensitivity', 'Parkinson Disease, Secondary-proposed-Hypokinesia', 'Death-correlate-Infarction', 'Death-constitute-Heart Failure', 'Chronic Disease-eradicated-Infections', 'Chronic Disease-reduce-Infections', 'Aphasia-sustain-Stroke', 'Aphasia-sustain-Language Disorders', 'Blister-show-Spinal Cord Diseases', 'Blister-contribute-Spinal Cord Diseases', 'Fractures, Bone-selected-Wounds and Injuries', 'Death-increased-Fractures, Bone', 'Angina, Unstable-examine-Death', 'Myocardial Infarction-examine-Death', 'Neoplasms-studied-Peptic Ulcer', 'Angina, Unstable-rose-Infarction', 'Fibromyalgia-lie-Pain', 'Fibromyalgia-occur-Musculoskeletal Diseases', 'Coronary Artery Disease-associated-Mitral Valve Insufficiency', 'Mitral Valve Insufficiency-associated-Coronary Artery Disease', 'Abortion, Septic-experience-Neoplasms', 'Malaria-increase-Infections', 'Creutzfeldt-Jakob Syndrome-react-Neurodegenerative Diseases', 'Gerstmann-Straussler-Scheinker Disease-react-Neurodegenerative Diseases', 'Hyperinsulinism-play-Diabetes Mellitus', 'Death-terminate-Heart Failure', 'Memory Disorders-investigate-Alzheimer Disease', 'Memory Disorders-include-Diffuse Neurofibrillary Tangles with Calcification', 'Memory Disorders-investigate-Diffuse Neurofibrillary Tangles with Calcification', 'Hematoma-include-Death', 'Embolism-superimposed-Lung Diseases', 'Embolism-underlie-Lung Diseases', 'Fractures, Bone-dissect-Aortic Aneurysm', 'Aortic Aneurysm-dissect-Pneumothorax', 'Hypertension-accelerate-Diabetes Mellitus', 'Diabetes Mellitus-represent-Hypertension', 'Retinal Arterial Macroaneurysm-seen-Dementia, Vascular', 'Vision Disorders-occur-Edema', 'Vision Disorders-occur-Hemorrhage', 'Vision Disorders-expedite-Retinal Detachment', 'Telangiectasis-include-Retinal Arterial Macroaneurysm', 'von Hippel-Lindau Disease-include-Retinal Arterial Macroaneurysm', 'Diabetes Mellitus-include-Retinal Arterial Macroaneurysm', 'Hemangioma-include-Retinal Arterial Macroaneurysm', 'Osteoarthritis-follow-Wounds and Injuries', 'Shock, Septic-occur-Infections', 'Shock, Septic-occur-Diabetes Mellitus', 'Heart Failure-dissect-Aneurysm', 'Stroke-dissect-Aneurysm', 'Leukemia, Myeloid, Acute-cause-Pregnancy, Prolonged', 'Hodgkin Disease-cause-Pregnancy, Prolonged', 'Neoplasms-benefit-Hodgkin Disease', 'Immunologic Deficiency Syndromes-characterized-Agammaglobulinemia', 'Cardiovascular Diseases-followed-Respiratory Insufficiency', 'Cardiovascular Diseases-followed-Endocrine System Diseases', 'Coronary Artery Disease-reduce-Angina Pectoris', 'Lupus Erythematosus, Systemic-studied-Hemochromatosis', 'Psychoses, Substance-Induced-acknowledged-Dementia', 'Neoplasms-rose-Multiple Myeloma', 'Death-rose-Multiple Myeloma', 'Lung Neoplasms-offered-Neoplasms', 'Death-encountered-Hypertension', 'Death-followed-Fibrosis', 'Carcinoma, Hepatocellular-play-Mastocytosis, Systemic', 'Drug-Related Side Effects and Adverse Reactions-observed-Death', 'Thyroid Crisis-evaluated-Arrhythmias, Cardiac', 'Arrhythmias, Cardiac-evaluated-Hyperthyroidism', 'Neoplasms-require-Pain', 'Delirium-find-Hip Fractures', 'Alzheimer Disease-find-Hip Fractures', 'Intestinal Obstruction-account-Hernia', 'Jaundice, Obstructive-operated-Pneumonia', 'Jaundice, Obstructive-operated-Urinary Tract Infections', 'Cough-blunted-Bradycardia', 'Tachycardia-blunted-Bradycardia', 'Bradycardia-blunted-Syncope', 'Ischemia-mimic-Gastrointestinal Diseases', 'Ischemia-mimic-Peptic Ulcer', 'Ischemia-mimic-Neoplasms', 'Ischemia-precede-Infarction', 'Hypertension-include-Shock', 'Stroke-include-Shock', 'Angina Pectoris-include-Shock', 'Chronic Disease-present-Psychomotor Agitation', 'Chronic Disease-present-Hallucinations', 'Pulmonary Atresia-associated-Death', 'Death-associated-Pulmonary Atresia', 'Infections-result-Bacteremia', 'Alzheimer Disease-compromise-Sleep Deprivation', 'Cerebral Infarction-contribute-Dementia, Vascular', 'Dementia-judged-Cerebral Infarction', 'Skin Diseases-involve-Skin Ulcer', 'Hypertension-experience-Death', 'Hypertension-experience-Myocardial Infarction', 'Hypertension-obtain-Stroke', 'Musculoskeletal Diseases-found-Osteoarthritis', 'Atrioventricular Block-paced-Arrhythmias, Cardiac', 'Coronary Artery Disease-result-Death', 'Death-related-Ventricular Septal Rupture', 'Kidney Diseases-seem-Immune System Diseases', 'Kidney Diseases-seem-Hypertension', 'Kidney Diseases-seem-Arteriosclerosis', 'Immune System Diseases-seem-Hypertension', 'Immune System Diseases-seem-Arteriosclerosis', 'Spondylitis-seen-Brucellosis', 'Aortic Valve Stenosis-misdiagnosed-Mitral Valve Insufficiency', 'Neoplasms-present-Heart Failure', 'Cerebral Hemorrhage-suggest-Cerebral Amyloid Angiopathy', 'Spinal Stenosis-result-Death', 'Osteosarcoma-associated-Achondroplasia', 'Achondroplasia-associated-Osteosarcoma', 'Cardiovascular Diseases-seen-Fractures, Bone', 'Fractures, Bone-seen-Diabetes Mellitus', 'Bacteriuria-represent-Infections', 'Tangier Disease-represent-Lysosomal Storage Diseases', 'Lung Neoplasms-included-Neoplasms', 'Myelodysplastic Syndromes-involve-Neutropenia', 'Myelodysplastic Syndromes-involve-Thrombocytopenia', 'Myelodysplastic Syndromes-involve-Anemia', 'Alzheimer Disease-reveal-Pallor', 'Fetal Growth Retardation-related-Thrombocytosis', 'Eclampsia-related-Thrombocytosis', 'Brain Diseases-account-Seizures', 'Stroke-account-Seizures', 'Neoplasms-account-Seizures', 'Neuroschistosomiasis-represent-Neoplasms', 'Neuroschistosomiasis-represent-Wounds and Injuries', 'Neuroschistosomiasis-represent-Intracranial Hemorrhage, Traumatic', 'Neoplasms-represent-Intracranial Hemorrhage, Traumatic', 'Wounds and Injuries-represent-Intracranial Hemorrhage, Traumatic', 'Arthritis, Rheumatoid-observed-Vasculitis', 'Death-analyzed-Angina Pectoris', 'Aneurysm-performed-Death', 'Anemia, Hypochromic-undergo-Hemorrhage', 'Neoplasms-noted-Stroke', 'Alzheimer Disease-suffer-Dementia, Vascular', 'Alzheimer Disease-imply-Chronic Disease', 'Seizures-influence-Kyphosis', 'Nephrotic Syndrome-result-Kidney Diseases', 'Nephrotic Syndrome-result-Diabetic Nephropathies', 'Diabetic Nephropathies-recover-Nephrotic Syndrome', 'Amyloidosis-recover-Nephrotic Syndrome', 'Glomerulonephritis, Membranous-recover-Nephrotic Syndrome', 'Kidney Failure, Chronic-assess-Horner Syndrome', 'Hearing Loss-hear-Hemiplegia', 'Meningeal Neoplasms-present-Gait Disorders, Neurologic', 'Death-culminate-Acute Kidney Injury', 'Death-continue-Acute Kidney Injury', 'Tremor-suffer-Headache', 'Acute Kidney Injury-suffer-Death', 'Cerebrovascular Disorders-observed-Hypertension', 'Hypertension-accelerate-Cerebrovascular Disorders', 'Death-include-Pressure Ulcer', 'Death-increase-Pressure Ulcer', 'Pulmonary Embolism-include-Death', 'Bronchopneumonia-include-Death', 'Atrioventricular Block-associated-Ventricular Premature Complexes', 'Ventricular Premature Complexes-associated-Atrioventricular Block', 'Atrioventricular Block-induce-Torsades de Pointes', 'Ventricular Premature Complexes-induce-Torsades de Pointes', 'Torsades de Pointes-show-Atrioventricular Block', 'Sepsis-accounted-Death', 'Thyrotoxicosis-encountered-Atrial Fibrillation', 'Atrial Fibrillation-encountered-Cerebrovascular Disorders', 'Inflammatory Bowel Diseases-identify-Malabsorption Syndromes', 'Dementia, Vascular-result-Thrombosis', 'Thrombosis-observed-Hypertension', 'Infections-caused-Prostatitis', 'Infections-caused-Osteomyelitis', 'Infections-caused-Pneumonia', 'Tetany-present-Abdominal Pain', 'Tetany-present-Vomiting', 'Stroke-result-Hemorrhage', 'Plaque, Atherosclerotic-lowering-Infarction', 'Lung Diseases-incriminated-Leukostasis', 'Lung Diseases-incriminated-Drug-Related Side Effects and Adverse Reactions', 'Lung Diseases-incriminated-Uremia', 'Osteoporosis-predispose-Bone Neoplasms', 'Osteoporosis-differentiate-Bone Diseases, Metabolic', 'Osteoporosis-differentiate-Osteomalacia', 'Nervous System Diseases-claim-Parkinson Disease', 'Graft vs Host Disease-lead-Pneumonia', 'Death-investigated-Subarachnoid Hemorrhage', 'Death-receive-Subarachnoid Hemorrhage', 'Fractures, Bone-investigated-Subarachnoid Hemorrhage', 'Fractures, Bone-receive-Subarachnoid Hemorrhage', 'Parkinsonian Disorders-become-Drug-Related Side Effects and Adverse Reactions', 'Parkinsonian Disorders-avoid-Drug-Related Side Effects and Adverse Reactions', 'Cushing Syndrome-characterize-Hypertension', 'Hypertension-remain-Kidney Failure, Chronic', 'Hypokalemia-prevented-Coronary Artery Disease', 'Hypokalemia-prevented-Hypertrophy, Left Ventricular', 'Hypokalemia-prevented-Diabetes Mellitus', 'Hypertension, Malignant-characterized-Endarteritis', 'Hypertension, Malignant-characterized-Necrosis', 'Myocardial Infarction-account-Stroke', 'Myocardial Infarction-account-Hypertension', 'Death-account-Hypertension', 'Stroke-account-Hypertension', 'Death-require-Cardiovascular Diseases', 'Seizures-follow-Brain Diseases', 'Epilepsy-experience-Stroke', 'Stroke-experience-Chronic Disease', 'Death-maintain-Hearing Loss, Unilateral', 'Jaundice-develop-Chemical and Drug Induced Liver Injury', 'Osteoarthritis-rank-Hypertension', 'Osteoarthritis-rank-Diabetes Mellitus', 'Hypertension-rank-Diabetes Mellitus', 'Osteoarthritis-suffer-Arthritis, Rheumatoid', 'Soft Tissue Neoplasms-suffer-Arthritis, Rheumatoid', 'Parkinson Disease-observed-Basal Ganglia Diseases', 'Tibial Neuropathy-accepted-Arthritis', 'Parkinson Disease-represent-Basal Ganglia Diseases', 'Tibial Neuropathy-performed-Coxa Vara', 'Colorectal Neoplasms-arise-Neoplasms', 'Chemical and Drug Induced Liver Injury-diagnosed-Focal Nodular Hyperplasia', 'Stomach Ulcer-confirm-Precancerous Conditions', 'Myocardial Infarction-develop-Takotsubo Cardiomyopathy', 'Coronary Artery Disease-identified-Stroke', 'Stroke-find-Hypertension', 'Communicable Diseases-explain-Death', 'Stroke-find-Diabetes Mellitus', 'Stroke-find-Myocardial Infarction', 'Calcinosis-display-Cardiomyopathy, Hypertrophic', 'Abnormalities, Drug-Induced-disfigure-Neoplasms', 'Abdominal Pain-look-Hernia', 'Airway Obstruction-prove-Hernia', 'Abdominal Pain-look-Neoplasms', 'Abdominal Pain-look-Aneurysm', 'Weight Loss-designed-Epilepsy, Absence', 'Blood Coagulation Disorders, Inherited-associated-Autoimmune Diseases', 'Autoimmune Diseases-associated-Blood Coagulation Disorders, Inherited', 'Osteomalacia-detected-Liver Cirrhosis, Biliary', 'Osteoporotic Fractures-detected-Liver Cirrhosis, Biliary', 'Osteoporotic Fractures-attributed-Liver Cirrhosis, Biliary', 'Arthralgia-include-Diabetes Mellitus', 'Diabetes Mellitus-include-Arthritis, Psoriatic', 'Diabetes Mellitus-intensified-Arthritis, Psoriatic', 'Arthralgia-intensified-Arthritis, Psoriatic', 'Communicable Diseases-focus-Diarrhea', 'Hyperglycemia-appear-Death', 'Hyperglycemia-hospitalized-Pneumonia', 'Hyperglycemia-admitted-Pneumonia', 'Drug Hypersensitivity-reported-Drug-Related Side Effects and Adverse Reactions', 'Alzheimer Disease-observed-Plaque, Amyloid', 'Osteoporosis-present-Back Pain', 'Headache-suffer-Vasculitis', 'Edema-rise-Adrenal Insufficiency', 'Coronary Artery Disease-controlled-Menstruation Disturbances', 'Coronary Artery Disease-controlled-Asthma', 'Drug-Related Side Effects and Adverse Reactions-treat-Arrhythmias, Cardiac', 'Chemical and Drug Induced Liver Injury-compared-Liver Diseases', 'Hypertension-show-Cardiomyopathy, Hypertrophic', 'Hypertension-cause-Cardiovascular Diseases', 'Hypertension-document-Coronary Artery Disease', 'Coronary Artery Disease-document-Hypertension', 'Coronary Artery Disease-suffer-Angina Pectoris', 'Multiple Sclerosis-suffer-Demyelinating Diseases', 'Hypotension-warrant-Hypertension', 'Hypertension-treat-Peripheral Vascular Diseases', 'Hypertension-associated-Peripheral Vascular Diseases', 'Peripheral Vascular Diseases-associated-Hypertension', 'Hypertension-treat-Coronary Artery Disease', 'Hypertension-treat-Arrhythmias, Cardiac', 'Hypertension-associated-Arrhythmias, Cardiac', 'Arrhythmias, Cardiac-associated-Hypertension', 'Hypertension-treat-Airway Obstruction', 'Hypertension-associated-Airway Obstruction', 'Airway Obstruction-associated-Hypertension', 'Hemolysis-lead-Anemia', 'Tachycardia, Supraventricular-seen-Atrial Premature Complexes', 'Alcoholism-start-Neoplasms', 'Arrhythmias, Cardiac-assess-Myocardial Infarction', 'Diabetes Mellitus-avoided-Diabetes Mellitus, Type 2', 'Communicable Diseases-modified-Death', 'Hyperthyroidism-present-Anorexia', 'Hyperthyroidism-present-Diarrhea', 'Hyperthyroidism-present-Atrial Fibrillation', 'Bacteremia-appear-Death', 'Melanoma-analyzed-Inert Gas Narcosis', 'Arthritis, Rheumatoid-cause-Neck Pain', 'Neoplasms-cause-Neck Pain', 'Pain-complicate-Arthritis, Rheumatoid', 'Neck Pain-complicate-Arthritis, Rheumatoid', 'Arthritis, Rheumatoid-produce-Radiculopathy', 'Arthritis, Rheumatoid-produce-Spinal Cord Diseases', 'Arthritis, Rheumatoid-produce-Nervous System Diseases', 'Radiculopathy-produce-Nervous System Diseases', 'Spinal Cord Diseases-produce-Nervous System Diseases', 'Hypertension-predispose-Coronary Artery Disease', 'Hypercholesterolemia-predispose-Coronary Artery Disease', 'Hypertension-fail-Coronary Artery Disease', 'Hypertension-fail-Death', 'Urinary Incontinence-report-Bacteriuria', 'Urinary Incontinence-questioned-Dysuria', 'Pain-questioned-Dysuria', 'Flank Pain-questioned-Dysuria', 'Fever-questioned-Dysuria', 'Anorexia-questioned-Dysuria', 'Cardiac Output, Low-questioned-Dysuria', 'Fatigue-questioned-Dysuria', 'Muscle Weakness-questioned-Dysuria', 'Bacteriuria-questioned-Dysuria', 'Infections-include-Mitral Valve Insufficiency', 'Stomach Neoplasms-consist-Neoplasms', 'Neoplasms-result-Stomach Neoplasms', 'Death-result-Peptic Ulcer', 'Ulcer-used-Duodenal Ulcer', 'Streptococcal Infections-present-Shock', 'Chronic Disease-cause-Muscle Weakness', 'Aneuploidy-found-Neoplasms', 'Heart Arrest-show-Tachycardia, Ventricular', 'Heart Arrest-show-Ventricular Fibrillation', 'Arrhythmias, Cardiac-occur-Graves Ophthalmopathy', 'Diabetes Mellitus-occur-Graves Ophthalmopathy', 'Hypertension-occur-Graves Ophthalmopathy', 'Cardiovascular Abnormalities-detected-Periapical Periodontitis', 'Pulmonary Embolism-observed-Heart Failure', 'Pulmonary Embolism-observed-Ventricular Premature Complexes', 'Pulmonary Embolism-observed-Atrial Fibrillation', 'Myopia-predispose-Cataract', 'Sclerosis-cause-Myopia', 'Polymyalgia Rheumatica-indicate-Myositis', 'Neuralgia-offer-Takotsubo Cardiomyopathy', 'Pain-experience-Hypesthesia', 'Trigeminal Neuralgia-considered-Takotsubo Cardiomyopathy', 'Pain-experience-Corneal Diseases', 'Dysgeusia-associated-Neoplasms', 'Neoplasms-associated-Dysgeusia', 'Death-define-Sleep Initiation and Maintenance Disorders', 'Hemorrhage-followed-Abdominal Pain', 'Hemorrhage-suspected-Fever', 'Hemorrhage-suspected-Hypotension', 'Hemorrhage-suspected-Hyponatremia', 'Abdominal Pain-followed-Hypotension', 'Abdominal Pain-followed-Hyponatremia', 'Abdominal Pain-develop-Hyponatremia', 'Prostatitis-fail-Reflex, Abnormal', 'Prostatitis-necessitate-Urinary Bladder Diseases', 'Reflex, Abnormal-necessitate-Urinary Bladder Diseases', 'Deglutition Disorders-reserved-Thrombosis', 'Deglutition Disorders-reserved-Embolism', 'Deglutition Disorders-attributed-Migraine Disorders', 'Hemiplegia-attributed-Migraine Disorders', 'Stroke-present-Neurologic Manifestations', 'Thrombosis-attributed-Migraine Disorders', 'Stroke-confused-Ischemia', 'Stroke-confused-Migraine Disorders', 'Embolism-attributed-Migraine Disorders', 'Neurologic Manifestations-confused-Ischemia', 'Ischemia-confused-Migraine Disorders', 'Neurologic Manifestations-attributed-Migraine Disorders', 'Stroke-attributed-Migraine Disorders', 'Ventricular Fibrillation-prevent-Death', 'Death-associated-Leukopenia', 'Leukopenia-associated-Death', 'Arteriosclerosis-accompanied-Thrombosis', 'Low Back Pain-investigated-Nerve Compression Syndromes', 'Essential Tremor-referred-Movement Disorders', 'Dyskinesia, Drug-Induced-associated-Essential Tremor', 'Essential Tremor-associated-Dyskinesia, Drug-Induced', 'Coronary Artery Disease-underlie-Atherosclerosis', 'Dyskinesia, Drug-Induced-associated-Dystonia', 'Dystonia-associated-Dyskinesia, Drug-Induced', 'Heart Diseases-underlie-Endocarditis', 'Endocarditis-underlie-Rheumatic Heart Disease', 'Epilepsies, Partial-exhibit-Mastocytosis, Systemic', 'Neurodegenerative Diseases-displace-Rheumatic Diseases', 'Neurodegenerative Diseases-displace-Heart Diseases', 'Neurodegenerative Diseases-underlie-Endocarditis', 'Stroke-increase-Cardiomyopathies', 'Rheumatic Diseases-displace-Endocarditis', 'Rheumatic Diseases-underlie-Endocarditis', 'Heart Diseases-displace-Endocarditis', 'Hernia-underlie-Mastocytosis, Systemic', 'Arteritis-described-Polymyalgia Rheumatica', 'Arteritis-described-Arthritis, Rheumatoid', 'Polymyalgia Rheumatica-suggest-Carotid Artery Injuries', 'Carotid Artery Injuries-suggest-Arteritis', 'Carotid Artery Injuries-suggest-Polymyalgia Rheumatica', 'Blindness-occur-Giant Cell Arteritis', 'Glucose Intolerance-contribute-Death', 'Glucose Metabolism Disorders-lead-Diabetes Mellitus', 'Glucose Metabolism Disorders-lead-Glucose Intolerance', 'Cocaine-Related Disorders-accelerate-Parkinson Disease, Secondary', 'Cardiovascular Diseases-become-Diabetes Mellitus', 'Neoplasms-involve-Esophageal Neoplasms', 'Neoplasms-involve-Esophageal Achalasia', 'Neoplasms-result-Esophageal Achalasia', 'Neoplasms-mimic-Esophageal Achalasia', 'Esophageal Neoplasms-result-Esophageal Achalasia', 'Esophageal Neoplasms-mimic-Esophageal Achalasia', 'Adenocarcinoma-originate-Stomach Neoplasms', 'Adenocarcinoma-caused-Carcinoma, Squamous Cell', 'Alzheimer Disease-provide-Cerebral Amyloid Angiopathy, Familial', 'Alzheimer Disease-provide-Plaque, Amyloid', 'Fractures, Bone-undergo-Musculoskeletal Diseases', 'Infections-appear-Diabetes Mellitus', 'Infections-suffer-Renal Insufficiency', 'Keratitis, Dendritic-found-Alzheimer Disease', 'Myelodysplastic Syndromes-require-Leukemia, Myeloid, Acute', 'Leukemia, Myeloid, Acute-display-Leukocytosis', 'Myelodysplastic Syndromes-display-Leukocytosis', 'Leukoedema, Oral-observed-Leukoplakia', 'Death-correlated-Gallstones', 'Death-correlated-Airway Obstruction', 'Gallstones-limited-Airway Obstruction', 'Gallstones-sustained-Airway Obstruction', 'Arrhythmias, Cardiac-caused-Hypokalemia', 'Arrhythmias, Cardiac-caused-Cardiomyopathy, Hypertrophic', 'Coronary Artery Disease-increase-Arrhythmias, Cardiac', 'Hypokalemia-increase-Arrhythmias, Cardiac', 'Magnesium Deficiency-regarded-Hypokalemia', 'Headache Disorders, Secondary-found-Alzheimer Disease', 'Myelodysplastic Syndromes-constitute-Genetic Diseases, Inborn', 'Alzheimer Disease-found-Motor Neuron Disease', 'Bone Marrow Diseases-suffer-Pancytopenia', 'Leukemia, Myeloid, Acute-precede-Hodgkin Disease', 'Bone Marrow Diseases-suffer-Immunologic Deficiency Syndromes', 'Dementia-increase-Neoplasms', 'Cross Infection-account-Infections', 'Cross Infection-associated-Death', 'Death-associated-Cross Infection', 'Cross Infection-contribute-Death', 'Wounds and Injuries-predispose-Pneumonia', 'Death-contribute-Cross Infection', 'Splenomegaly-separate-Dystonia', 'Splenomegaly-separate-Thrombosis', 'Dystonia-separate-Thrombosis', 'Dystonia-present-Brain Ischemia', 'Dystonia-present-Hemorrhage', 'Endometrial Hyperplasia-prevent-Bone Neoplasms', 'Breast Neoplasms-prevent-Bone Neoplasms', 'Gastritis-avoid-Hemorrhage', 'Osteoporosis-entail-Death', 'Immunologic Deficiency Syndromes-depend-Infections', 'Hypokalemia-associated-Death', 'Death-associated-Hypokalemia', 'Memory Disorders-found-Brain Diseases', 'Neoplasms-cause-Hearing Loss', 'Neoplasms-cause-Tinnitus', 'Polycythemia Vera-see-Primary Myelofibrosis', 'Aortic Valve Insufficiency-present-Abducens Nerve Diseases', 'Epilepsy-treated-Neuralgia', 'Seizures-treated-Neuralgia', 'Hypothyroidism-associate-Chronic Disease', 'Chronic Disease-associate-Hypothyroidism', 'Tuberculosis-noted-Fever', 'Tuberculosis-noted-Weight Loss', 'Bronchitis-result-Asthma', 'Multiple Organ Failure-exist-Heart Failure', 'Multiple Organ Failure-exist-Atrial Fibrillation', 'Carcinoma, Mucoepidermoid-followed-Adenocarcinoma', 'Carcinoma, Mucoepidermoid-followed-Carcinoma, Adenoid Cystic', 'Carcinoma, Mucoepidermoid-followed-Cystadenocarcinoma, Papillary', 'Ulcer-remain-Hemorrhage', 'Genetic Diseases, Inborn-undergo-Death', 'Dementia-diagnosed-Hallucinations', 'Heart Failure-follow-Cardiomyopathies', 'Heart Failure-follow-Infarction', 'Heart Failure-caused-Infarction', 'Heart Failure-follow-Central Nervous System Diseases', 'Cardiomyopathies-caused-Infarction', 'Nervous System Malformations-seen-Chromosome Aberrations', 'Parkinsonian Disorders-exhibit-Hypothalamic Diseases', 'Hypothalamic Neoplasms-noted-Parkinson Disease, Postencephalitic', 'Coronary Artery Disease-offer-Hypertension', 'Coronary Artery Disease-offer-Heart Failure', 'Hypertension-look-Aneurysm', 'Hypertension-used-Renal Insufficiency', 'Infections-play-Hodgkin Disease', 'Hodgkin Disease-increased-Infections', 'Hodgkin Disease-increased-Infectious Mononucleosis', 'Infections-increased-Infectious Mononucleosis', 'Adenocarcinoma-include-Myositis', 'Hyperplasia-include-Muscular Disorders, Atrophic', 'Crohn Disease-evaluate-Diarrhea', 'Crohn Disease-evaluate-Abdominal Pain', 'Crohn Disease-evaluate-Weight Loss', 'Crohn Disease-evaluate-Hemorrhage', 'Glucose Intolerance-present-Thrombosis', 'Glucose Intolerance-represent-Diabetes Mellitus', 'Stroke-represent-Diabetes Mellitus', 'Death-analysed-Glomerulonephritis', 'Tremor-detected-Dyskinesia, Drug-Induced', 'Death-predicted-Glomerulonephritis', 'Uremia-predicted-Glomerulonephritis', 'Parkinsonian Disorders-occur-Dyskinesia, Drug-Induced', 'Dyskinesia, Drug-Induced-exhibit-Parkinsonian Disorders', 'Death-associated-Bacteriuria', 'Bacteriuria-associated-Death', 'Shock, Cardiogenic-undergo-Ventricular Septal Rupture', 'Shock, Cardiogenic-undergo-Mitral Valve Insufficiency', 'Shock, Cardiogenic-undergo-Heart Failure', 'Syncope-result-Wounds and Injuries', 'Neoplasms-diagnosed-Ovarian Neoplasms', 'Ovarian Neoplasms-diagnosed-Neoplasms', 'Death-reveal-Syncope', 'Death, Sudden-reveal-Syncope', 'Arthritis-disabled-Gout', 'Myocardial Infarction-ease-Pain', 'Pancreatitis, Acute Necrotizing-evaluated-Pancreatitis', 'Death-diminish-Pancreatitis, Acute Necrotizing', 'Pancreatitis, Acute Necrotizing-evaluated-Necrosis', 'Hyperplasia-weigh-Cardiomegaly', 'Calcinosis-calculated-Atherosclerosis', 'Myxoma-present-Arteriosclerosis', 'Neoplasms-experience-Respiratory Distress Syndrome', 'Diarrhea-cause-Steatorrhea', 'Diarrhea-monitored-Hypokalemia', 'Steatorrhea-monitored-Hypokalemia', 'Steatorrhea-cause-Hypokalemia', 'Hyperkalemia-occur-Renal Insufficiency', 'Communicable Diseases-result-Vision Disorders', 'Bacteriuria-assess-Infections', 'Death-treat-Hypertension', 'Appendicitis-delay-Constipation', 'Seizures-admitted-Epilepsy', 'Femoral Fractures-caused-Wounds and Injuries', 'Vestibulocochlear Nerve Injuries-undergo-Death', 'Hyperlipoproteinemia Type II-detected-Lipodystrophy', 'Infarction-found-Kidney Tubular Necrosis, Acute', 'Infarction-found-Renal Insufficiency', 'Neoplasms-misattributed-Death', 'Death-misattributed-Pneumonia', 'Death-indicate-Pancreatic Neoplasms', 'Necrosis-necessitate-Pain', 'Death-intervene-Cardiovascular Diseases', 'Cardiovascular Diseases-impair-Hypotension', 'Death-reflect-Cardiomyopathies', 'Cardiovascular Diseases-reflect-Cardiomyopathies', 'Ischemia-lead-Gangrene', 'Sleep Wake Disorders-occur-Sleep Apnea Syndromes', 'Sleep Apnea Syndromes-defined-Apnea', 'Sleep Apnea Syndromes-defined-Alzheimer Disease', 'Sleep Apnea Syndromes-occur-Alzheimer Disease', 'Apnea-occur-Alzheimer Disease', 'Carcinoid Tumor-account-Appendicitis', 'Hyperplasia-account-Appendicitis', 'Neoplasms-account-Appendicitis', 'Appendicitis-obstruct-Colonic Neoplasms', 'Appendicitis-evaluated-Colonic Neoplasms', 'Disease-accept-Granulomatosis with Polyangiitis', 'Erectile Dysfunction-classified-Impotence, Vasculogenic', 'Tuberculosis-tend-Hematologic Diseases', 'Tuberculosis-considered-Fever', 'Head and Neck Neoplasms-presented-Neoplasms', 'Atrial Fibrillation-complicate-Myocardial Infarction', 'Neoplasms-rule-Dysphonia', 'Atrial Fibrillation-develop-Heart Failure', 'Atrial Fibrillation-develop-Bundle-Branch Block', 'Cholecystitis, Acute-found-Empyema', 'Cholecystitis, Acute-found-Gangrene', 'Biliary Tract Diseases-associated-Death', 'Death-associated-Biliary Tract Diseases', 'Vitreous Detachment-Complete-Diabetes Mellitus', 'Vitreous Detachment-occur-Diabetes Mellitus', 'Urinary Incontinence-associated-Sleep Initiation and Maintenance Disorders', 'Sleep Initiation and Maintenance Disorders-associated-Urinary Incontinence', 'Cardiac Output, Low-predict-Coronary Artery Disease', 'Cardiac Output, Low-predict-Aortic Valve Stenosis', 'Myocardial Infarction-predicted-Coronary Artery Disease', 'Sarcoma, Kaposi-occur-Acquired Immunodeficiency Syndrome', 'Liver Neoplasms-account-Neoplasms', 'Liver Neoplasms-account-Penile Neoplasms', 'Liver Neoplasms-account-Sarcoma, Kaposi', 'Arthritis, Rheumatoid-cause-Drug-Related Side Effects and Adverse Reactions', 'Drug-Related Side Effects and Adverse Reactions-manifested-Tinnitus', 'Drug-Related Side Effects and Adverse Reactions-manifested-Hearing Loss', 'Hypertension-reported-Microvascular Angina', 'Echinococcosis-develop-Infections', 'Hypertension-reported-Diabetes Mellitus', 'Infections-cause-Osteomyelitis', 'Hypercalcemia-show-Acute Kidney Injury', 'Ascites-account-Tuberculosis', 'Hypercalcemia-considered-Parathyroid Neoplasms', 'Hypercalcemia-observed-Hemorrhage', 'Hypercalcemia-observed-Parathyroid Neoplasms', 'Hyperthyroidism-present-Thyrotoxicosis', 'Euthyroid Sick Syndromes-distinguish-Hyperthyroidism', 'Diabetes Mellitus-take-Arteriosclerosis', 'Arrhythmias, Cardiac-record-Syncope', 'Hypotension-found-Cardiomyopathy, Hypertrophic', 'Neuralgia-ameliorate-Pain', 'Urinary Tract Infections-caused-Klebsiella Infections', 'Infections-caused-Klebsiella Infections', 'Urinary Tract Infections-contribute-Bacteremia', 'Urinary Tract Infections-contribute-Sepsis', 'Urinary Tract Infections-contribute-Death', 'Cross Infection-contribute-Bacteremia', 'Cross Infection-contribute-Sepsis', 'Dermatitis, Photoallergic-evolve-Pseudolymphoma', 'Hypertension-employ-Death', 'Hypokalemia-contribute-Death', 'Infections-trained-Cross Infection', 'Brain Ischemia-result-Stroke', 'Infections-predisposed-Acute Disease', 'Diabetes Mellitus, Type 2-found-Hyperglycemia', 'Hyperglycemia-found-Diabetes Mellitus, Type 2', 'Glucose Metabolism Disorders-presented-Diabetes Mellitus', "Carcinoma, Acinar Cell-mentioned-Sjogren's Syndrome", "Fibrosis-mentioned-Sjogren's Syndrome", 'Pneumonia-recognize-Infections', "Hyperplasia-mentioned-Sjogren's Syndrome", 'Kidney Diseases-postpone-Kidney Failure, Chronic', 'Aortic Aneurysm, Abdominal-complicated-Ureteral Obstruction', 'Ureteral Obstruction-related-Retroperitoneal Fibrosis', 'Ureteral Obstruction-related-Aneurysm', 'Aneurysm-resolve-Retroperitoneal Fibrosis', 'Aneurysm-resolve-Ureteral Obstruction', 'Aortic Aneurysm-considered-Ureteral Obstruction', 'Retroperitoneal Fibrosis-resolve-Ureteral Obstruction', 'Gastrointestinal Hemorrhage-found-Hemorrhage', 'Hemorrhage-related-Angiodysplasia', 'Angina Pectoris-occur-Sick Sinus Syndrome', 'Myocardial Infarction-occur-Sick Sinus Syndrome', 'Heart Failure-occur-Sick Sinus Syndrome', 'Death-occur-Sick Sinus Syndrome', 'Skin Diseases-resolve-Drug Eruptions', 'Hemorrhage-occur-Ulcer', 'Arthritis, Rheumatoid-associated-Psychomotor Disorders', 'Psychomotor Disorders-associated-Arthritis, Rheumatoid', 'Drug Hypersensitivity-increased-Fractures, Bone', 'Drug Hypersensitivity-increased-Syncope', 'Hemorrhage-identify-Thrombocytopenia', 'Hemorrhage-identify-Anemia', 'Drug Hypersensitivity-warrant-Syncope', 'Hemorrhage-associated-Disseminated Intravascular Coagulation', 'Disseminated Intravascular Coagulation-associated-Hemorrhage', 'Dementia-associated-Renal Tubular Transport, Inborn Errors', 'Renal Tubular Transport, Inborn Errors-associated-Dementia', 'Malnutrition-experience-Alzheimer Disease', 'Hypertension-experience-Stroke', 'Granulomatous Disease, Chronic-consist-Infections', 'Granulomatous Disease, Chronic-suggest-Infections', 'Hypertension-avoided-Hypotension', 'Hypotension-result-Brain Ischemia', 'Aneurysm-observed-Hypertension', 'Hemorrhage-attribute-Dilatation, Pathologic', 'Hemorrhage-attribute-Diverticulum', 'Neurologic Manifestations-described-Amyloidosis, Familial', 'Paraproteinemias-result-Amyloidosis', 'Inflammation-result-Paraproteinemias', 'Infections-associated-Cholecystitis, Acute', 'Cholecystitis, Acute-associated-Infections', 'Cholecystitis, Acute-occur-Airway Obstruction', 'Amyloidosis-associated-Paraproteinemias', 'Paraproteinemias-associated-Amyloidosis', 'Neoplasms-cause-Cachexia', 'Communicable Diseases-appear-Diabetes Mellitus', 'Infections-accelerate-Neoplasms', 'Infections-test-Chromosome Aberrations', 'Sarcoma-test-Chromosome Aberrations', 'Neoplasms-classified-Sarcoma', 'Sleep Initiation and Maintenance Disorders-accumulate-Ataxia', 'Neurotoxicity Syndromes-characterized-Delirium', 'Neurotoxicity Syndromes-characterized-Cerebellar Diseases', 'Genetic Diseases, Inborn-include-Dementia', 'Genetic Diseases, Inborn-persist-Dementia', 'Genetic Diseases, Inborn-include-Delirium', 'Genetic Diseases, Inborn-persist-Delirium', 'Angina Pectoris-cause-Fatigue', 'Hypotension-cause-Fatigue', 'Hypertension-predispose-Eye Hemorrhage', 'Pain-develop-Gangrene', 'Skin Ulcer-develop-Gangrene', 'Necrosis-develop-Gangrene', 'Cardiovascular Abnormalities-occur-Alzheimer Disease', 'Death-include-Urinary Incontinence', 'Death-found-Urinary Incontinence', 'Pneumonia-detect-Pneumococcal Infections', 'Pneumococcal Infections-detect-Bronchitis', 'Hernia, Hiatal-undertaken-Esophageal Neoplasms', 'Pain-produced-Neoplasm Metastasis', 'Hypertension-lowering-Cardiovascular Diseases', 'Polyneuropathies-related-Diabetes Mellitus', 'Carpal Tunnel Syndrome-related-Diabetes Mellitus', 'Infections-thought-Sleep Initiation and Maintenance Disorders', 'Arteritis-remain-Anemia', 'Death-reduced-Respiratory Tract Diseases', 'Fever-show-Arthritis, Juvenile', 'Aspergillosis-occur-Candidiasis', 'Aspergillosis-occur-Cryptococcosis', 'Exanthema-show-Arthritis, Juvenile', 'Neurologic Manifestations-developed-Aspergillosis', 'Neurologic Manifestations-developed-Candidiasis', 'Lung Diseases-produce-Hypoxia', 'Lung Diseases-result-Vascular Headaches', 'Sleep Apnea Syndromes-produce-Hypoxia', 'Sleep Apnea Syndromes-result-Vascular Headaches', 'Hypoxia-result-Vascular Headaches', 'Migraine Disorders-offered-Glaucoma', 'Migraine Disorders-offered-Arteritis', 'Migraine Disorders-offered-Cerebrovascular Disorders', 'Atrial Fibrillation-measure-Stroke', 'Heart Valve Diseases-measure-Stroke', 'Stroke-measure-Airway Obstruction', 'Pneumonia-characterized-Death', 'Migraine Disorders-used-Ischemia', 'Migraine Disorders-produce-Cerebrovascular Disorders', 'Migraine Disorders-produce-Neurologic Manifestations', 'Migraine Disorders-produce-Headache', 'Hypertension-localize-Pain', 'Ischemia-produce-Neurologic Manifestations', 'Ischemia-produce-Headache', 'Headache-localize-Pain', 'Cerebrovascular Disorders-produce-Neurologic Manifestations', 'Cerebrovascular Disorders-produce-Headache', 'Neurologic Manifestations-produce-Headache', 'Death-related-Thromboembolism', 'Ulcer-occur-Hemorrhage', 'Pyuria-support-Pyelonephritis', 'Multiple Myeloma-follow-Leukemia, Lymphocytic, Chronic, B-Cell', 'Lymphoma-follow-Leukemia, Lymphocytic, Chronic, B-Cell', 'Leukemia, Myeloid-follow-Leukemia, Lymphocytic, Chronic, B-Cell', 'Neurodegenerative Diseases-become-Heart Failure', 'Neurodegenerative Diseases-become-Endocarditis', 'Atrial Fibrillation-studied-Myocardial Infarction', 'Heart Failure-underlie-Endocarditis', 'Death-base-Atrial Fibrillation', 'Atrial Fibrillation-base-Infarction', 'Atrial Fibrillation-base-Pericarditis', 'Death-base-Infarction', 'Death-base-Pericarditis', 'Peutz-Jeghers Syndrome-accompanied-Colorectal Neoplasms', 'Genetic Diseases, Inborn-accompanied-Colorectal Neoplasms', 'Adenomatous Polyposis Coli-develop-Colorectal Neoplasms', 'Gardner Syndrome-develop-Colorectal Neoplasms', 'Adenomatous Polyposis Coli-experienced-Neoplasms', 'Colorectal Neoplasms-carried-Blood Platelet Disorders', 'Gardner Syndrome-experienced-Neoplasms', 'Peutz-Jeghers Syndrome-experienced-Neoplasms', 'Colorectal Neoplasms-develop-Genetic Diseases, Inborn', 'Colorectal Neoplasms-develop-Carcinogenesis', 'Neoplasms-present-Genetic Diseases, Inborn', 'Neoplasms-present-Blood Platelet Disorders', 'Hepatitis B-characterized-Liver Failure', 'Neoplasms-represented-Cross Infection', 'Arteritis-cause-Myalgia', 'Polymyalgia Rheumatica-involve-Pain', 'Arthritis, Rheumatoid-involve-Pain', 'Polymyalgia Rheumatica-require-Arteritis', 'Polymyalgia Rheumatica-prevent-Blindness', 'Parkinson Disease, Secondary-associated-Hypokinesia', 'Hypokinesia-associated-Parkinson Disease, Secondary', 'Hypokinesia-associated-Stroke, Lacunar', 'Stroke, Lacunar-associated-Hypokinesia', 'Parkinson Disease, Secondary-associated-Stroke, Lacunar', 'Stroke, Lacunar-associated-Parkinson Disease, Secondary', 'Colonic Neoplasms-carry-Death', 'Hematoma-differentiate-Aortic Diseases', 'Aortic Diseases-differentiate-Intracranial Hemorrhages', 'Proteinuria-include-Diabetic Nephropathies', 'Renal Insufficiency-include-Diabetic Nephropathies', 'Diabetes Mellitus-diagnosed-Proteinuria', 'Proteinuria-appear-Renal Insufficiency', 'Nerve Degeneration-seen-Parkinson Disease', 'Angina Pectoris-show-Coronary Stenosis', 'Atherosclerosis-interact-Spasm', 'Atherosclerosis-lead-Coronary Vasospasm', 'Angina Pectoris-interact-Spasm', 'Angina Pectoris-lead-Coronary Vasospasm', 'Immunologic Deficiency Syndromes-reflect-Lymphoma, B-Cell', 'Thyroid Crisis-show-Calcinosis', 'Stroke-cause-Thrombosis', 'Rheumatic Heart Disease-lead-Atrial Fibrillation', 'Rheumatic Heart Disease-lead-Rheumatic Fever', 'Hypertrophy-develop-Inflammation', 'Sleep Wake Disorders-cover-Sleep Initiation and Maintenance Disorders', 'Sleep Wake Disorders-treat-Sleep Initiation and Maintenance Disorders', 'Infections-reflected-Anemia', 'Pneumococcal Infections-reflected-Anemia', 'Tetany-reflected-Anemia', 'Death-reduce-Communicable Diseases', 'Hypothyroidism-caused-Autoimmune Diseases', 'Hypothyroidism-caused-Hyperthyroidism', 'Priapism-lead-Erectile Dysfunction', 'Osteoarthritis-described-Cartilage Diseases', 'Osteoarthritis-compare-Cartilage Diseases', 'Orbital Cellulitis-produce-Pain', 'Orbital Cellulitis-produce-Edema', 'Orbital Cellulitis-compromise-Ocular Motility Disorders', 'Pain-compromise-Ocular Motility Disorders', 'Edema-compromise-Ocular Motility Disorders', 'Blepharoptosis-cause-Intracranial Aneurysm', 'Alzheimer Disease-seem-Hepatomegaly', 'Cholecystitis, Acute-face-Death', 'Arthritis-include-Joint Diseases', 'Arthritis-underlie-Joint Diseases', 'Arthritis-underlie-Infections', 'Puberty, Delayed-include-Arthritis', 'Joint Diseases-underlie-Puberty, Delayed', 'Infections-underlie-Puberty, Delayed', 'Hyperpigmentation-permit-Werner Syndrome', 'Heart Failure-result-Coronary Artery Disease', 'Heart Failure-result-Heart Valve Diseases', 'Heart Failure-result-Cardiomyopathies', 'Polycythemia-observed-Thrombocythemia, Essential', 'Hypotension-observed-Thrombocythemia, Essential', 'Dementia, Vascular-show-Death', 'Dementia, Vascular-show-Urinary Incontinence', 'Death-show-Urinary Incontinence', 'Emphysema-thought-Airway Obstruction', 'Emphysema-thought-Rupture', 'Neoplasms-presented-Death', 'Neoplasms-utilize-Death', 'Endomyocardial Fibrosis-undergo-Neoplasms', 'Myoclonus-play-Coronary Artery Disease', 'Arthritis, Rheumatoid-undergo-Rheumatic Diseases', 'Memory Disorders-associated-Amnesia', 'Amnesia-associated-Memory Disorders', 'Olfaction Disorders-followed-Parkinsonian Disorders', 'Ventricular Premature Complexes-contribute-Death', 'Hypokalemia-occur-Coronary Artery Disease', 'Memory Disorders-recognized-Dementia', 'Alzheimer Disease-reduced-Dementia', 'Chemical and Drug Induced Liver Injury-detected-Liver Cirrhosis', 'Arteriosclerosis-take-Diabetes Mellitus', 'Arteriosclerosis-take-Lupus Vasculitis, Central Nervous System', 'Hypertrophy-compared-Aortic Valve Stenosis', 'Hypertrophy-associated-Heart Failure, Diastolic', 'Heart Failure, Diastolic-associated-Hypertrophy', 'Edema-seen-Atrophy', 'Infections-reduce-Neoplasms', 'Infections-reduce-Autoimmune Diseases', 'Substance-Related Disorders-apply-Sleep Initiation and Maintenance Disorders', 'Substance-Related Disorders-apply-Psychomotor Agitation', 'Calcinosis-favour-Thrombosis', 'Osteoporosis-include-Immunologic Deficiency Syndromes', 'Arteriosclerosis-include-Immunologic Deficiency Syndromes', 'Alzheimer Disease-appear-Gait Disorders, Neurologic', 'Hypokalemia-predispose-Arrhythmias, Cardiac', 'Testicular Diseases-described-Pneumonia, Lipid', 'Testicular Diseases-characterized-Edema', 'Focal Nodular Hyperplasia-develop-Multiple Endocrine Neoplasia', 'Substance-Related Disorders-omitted-Fever', 'Substance-Related Disorders-omitted-Arrhythmias, Cardiac', 'Substance-Related Disorders-omitted-Iatrogenic Disease', 'Motor Neuron Disease-associate-Bulbar Palsy, Progressive', 'Bulbar Palsy, Progressive-associate-Motor Neuron Disease', 'Retinal Detachment-differentiate-Retinal Neovascularization', 'Multiple Trauma-evaluated-Wounds and Injuries', 'Chronic Disease-characterized-Memory Disorders', 'Rhinitis, Vasomotor-evaluate-Flushing', 'Death-analysed-Hip Fractures', 'Femoral Fractures-predict-Death', 'Coronary Artery Disease-increase-Angina Pectoris', 'Atrioventricular Block-compared-Dementia', 'Nephrosis, Lipoid-respond-Nephrotic Syndrome', 'Renal Insufficiency-include-Nephritis', 'Diabetes Mellitus-correlated-Retinal Diseases', 'Diabetes Mellitus-correlated-Proteinuria', 'Hypotension-correlated-Retinal Diseases', 'Peptic Ulcer-undergo-Ulcer', 'Peritoneal Neoplasms-undergo-Ulcer', 'Peritoneal Neoplasms-undergo-Death', 'Ulcer-undergo-Death', 'Muscular Dystrophy, Emery-Dreifuss-obtained-Hip Fractures', 'Muscular Diseases-preserved-Hip Fractures', 'Candidiasis-emanate-Leukemia, T-Cell', 'Leukemia, T-Cell-emanate-Leukoplakia', 'Xeroderma Pigmentosum-contract-Skin Neoplasms', 'Tachycardia, Ventricular-assessed-Heart Diseases', 'Thrombosis-studied-Myocardial Infarction', 'Cerebral Infarction-suggest-Embolism', 'Intracranial Arteriosclerosis-suggest-Embolism', 'Constriction, Pathologic-produced-Rheumatic Diseases', 'Constriction, Pathologic-produced-Calcinosis', 'Heart Valve Diseases-include-Vascular Calcification', 'Heart Valve Diseases-include-Fibrosis', 'Hearing Loss-involve-Neurologic Manifestations', 'Apnea-base-Sleep Apnea Syndromes', 'Retinal Detachment-complicated-Vitreoretinopathy, Proliferative', 'Delirium-followed-Dementia', 'Delirium-followed-Coma', 'Death-caused-Tuberculosis', 'Meningitis, Bacterial-occur-Death', 'Meningitis-cause-Death', 'Arteriosclerosis-increase-Hypertension', 'Nijmegen Breakage Syndrome-seen-Ataxia Telangiectasia', 'Leukemia-seen-Ataxia Telangiectasia', 'Carcinoma-seen-Ataxia Telangiectasia', 'Osteoporosis-present-Heart Failure', 'Heart Failure-result-Bone Diseases', 'Fractures, Bone-result-Bone Diseases', 'Leukemia, Myeloid, Acute-cause-Death', 'Brain Injury, Chronic-constitute-Dementia', 'Death-related-Renal Insufficiency', 'Ventricular Dysfunction, Left-done-Death', 'Ventricular Dysfunction, Left-performed-Death', 'Hemostatic Disorders-result-Hemorrhage', 'Craniocerebral Trauma-result-Fractures, Bone', 'Parkinson Disease-differentiate-Dementia', 'Parkinson Disease, Secondary-unmask-Parkinson Disease', 'Azotemia-occur-Hypertension, Renovascular', 'Osteomalacia-defined-Osteoma, Osteoid', 'Osteomalacia-covered-Osteoma, Osteoid', 'Dementia-seen-Hydrocephalus', 'Carcinogenesis-produce-Neoplasms', 'Death-found-Atrial Fibrillation', 'Death-found-Atrioventricular Block', 'Death-associated-Bundle-Branch Block', 'Bundle-Branch Block-associated-Death', 'Lymphopenia-develop-Bacterial Infections', 'Death-associated-Ventricular Premature Complexes', 'Ventricular Premature Complexes-associated-Death', 'Chest Pain-used-Myocardial Infarction', 'Rupture-herald-Abdominal Pain', 'Rupture-herald-Uterine Hemorrhage', 'Osteoporosis-complicated-Vasculitis', 'Wounds and Injuries-complicated-Vasculitis', 'Pain, Postoperative-appear-Wounds and Injuries', 'Wounds and Injuries-appear-Pain, Postoperative', 'Fractures, Bone-involved-Wounds and Injuries', 'Bacteremia-occur-Pyelonephritis', 'Bacteremia-performed-Pyelonephritis', 'Bacteremia-suffer-Pneumococcal Infections', 'Mitral Valve Insufficiency-associated-Mitral Valve Stenosis', 'Mitral Valve Stenosis-associated-Mitral Valve Insufficiency', 'Calcinosis-increase-Heart Failure', 'Synovitis-predispose-Sepsis', 'Musculoskeletal Diseases-caused-Fractures, Bone', 'Neuroendocrine Tumors-ameliorate-Neurodegenerative Diseases', 'Anemia-behave-Gastritis', 'Duodenal Ulcer-behave-Gastritis', 'Death-associated-Neoplastic Syndromes, Hereditary', 'Neoplastic Syndromes, Hereditary-associated-Death', 'Immunologic Deficiency Syndromes-cause-Diabetes Mellitus', 'Hypothyroidism-included-Thyroid Diseases', 'Thyroid Crisis-included-Thyroid Diseases', 'Cataract-combined-Ocular Hypertension', 'Cataract-associated-Ocular Hypertension', 'Ocular Hypertension-associated-Cataract', 'Cataract-associated-Glaucoma', 'Glaucoma-associated-Cataract', 'Dilatation, Pathologic-discarded-von Willebrand Diseases', 'Arthritis, Psoriatic-indicated-Liver Diseases', 'Arthritis-studied-Rheumatic Diseases', 'Aneurysm-show-Hypertrophy, Left Ventricular', 'Hypertension-compared-Subarachnoid Hemorrhage', 'Hypertension-compared-Aneurysm', 'Aneurysm-compared-Subarachnoid Hemorrhage', 'Retinal Diseases-compared-Diabetes Mellitus', 'Hypertension-suffer-Arteriosclerosis Obliterans', 'Psychoses, Substance-Induced-manage-Dyskinesia, Drug-Induced', 'Reflex, Abnormal-associated-Nervous System Diseases', 'Nervous System Diseases-associated-Reflex, Abnormal', 'Reflex, Abnormal-associated-Sclerosis', 'Sclerosis-associated-Reflex, Abnormal', 'Reflex, Abnormal-associated-Stroke', 'Stroke-associated-Reflex, Abnormal', 'Reflex, Abnormal-associated-Spinal Cord Injuries', 'Spinal Cord Injuries-associated-Reflex, Abnormal', 'Reflex, Abnormal-associated-Parkinson Disease, Secondary', 'Parkinson Disease, Secondary-associated-Reflex, Abnormal', 'Reflex, Abnormal-associated-Urinary Bladder Neck Obstruction', 'Urinary Bladder Neck Obstruction-associated-Reflex, Abnormal', 'Reflex, Abnormal-associated-Airway Obstruction', 'Airway Obstruction-associated-Reflex, Abnormal', 'Reflex, Abnormal-explain-Airway Obstruction', 'Neoplasms-anchor-Graft vs Host Disease', 'Death, Sudden-attributed-Tuberculosis', 'Atrophy-study-Nervous System Diseases', 'Meningeal Neoplasms-produce-Death', 'Hydrocephalus-produce-Death', 'Tuberculosis-followed-Tuberculosis, Meningeal', 'Facial Nerve Injuries-result-Fractures, Bone', 'Cataract-decrease-Mastocytosis, Systemic', 'Hyponatremia-associated-Neurologic Manifestations', 'Neurologic Manifestations-associated-Hyponatremia', 'Nervous System Diseases-admitted-Hyponatremia', 'Hodgkin Disease-seen-Neoplasms', 'Heart Diseases-increase-Hypertension', 'Heart Diseases-increase-Diabetes Mellitus', 'Hip Fractures-carry-Death', 'Proctitis-caused-Fibromuscular Dysplasia', 'Cerebrovascular Disorders-related-Hypertension', 'Cerebrovascular Disorders-coexist-Cerebral Amyloid Angiopathy', 'Cardiomegaly-related-Hypertension', 'Cardiomegaly-related-Cerebral Amyloid Angiopathy', 'Cardiomegaly-coexist-Cerebral Amyloid Angiopathy', 'Hypertension-coexist-Cerebral Amyloid Angiopathy', 'Cerebral Amyloid Angiopathy-superimposed-Dementia', 'Cerebral Hemorrhage-superimposed-Dementia', 'Hemorrhage-superimposed-Dementia', 'Mitochondrial Diseases-play-Immunologic Deficiency Syndromes', 'Pulmonary Disease, Chronic Obstructive-estimated-Signs and Symptoms, Respiratory', 'Pulmonary Disease, Chronic Obstructive-run-Signs and Symptoms, Respiratory', 'Death-preceded-Acidosis', 'Headache Disorders, Secondary-produced-Cough', 'Headache Disorders, Secondary-precipitate-Pulmonary Disease, Chronic Obstructive', 'Cough-precipitate-Pulmonary Disease, Chronic Obstructive', 'Pneumococcal Infections-disturb-Death', 'Death-seen-Infections', 'Delirium-herald-Death', 'Hypertension-unassociated-Coronary Artery Disease', 'Stroke-support-Hypertension', 'Chest Pain-present-Arrhythmias, Cardiac', 'Chest Pain-present-Syncope', 'Chest Pain-present-Mitral Valve Insufficiency', 'Syncope-include-Arrhythmias, Cardiac', 'Mitral Valve Insufficiency-include-Arrhythmias, Cardiac', 'Arrhythmias, Cardiac-include-Chronobiology Disorders', 'Death-attributed-Chemical and Drug Induced Liver Injury', 'Liver Diseases-caused-Chemical and Drug Induced Liver Injury', 'Intracranial Hemorrhages-account-Death', 'Hemorrhage-considered-Ulcer', 'Hemorrhage-indicated-Hematoma, Subdural', 'Ulcer-indicated-Hematoma, Subdural', 'Facial Pain-produced-Tics', 'Angina, Unstable-include-Cardiomegaly', 'Death-fail-Failed Back Surgery Syndrome', 'Cardiomegaly-include-Aortic Valve Insufficiency', 'Cardiomegaly-include-Stroke', 'Cardiomegaly-include-Psychoses, Substance-Induced', 'Hypertension-include-Psychoses, Substance-Induced', 'Colitis, Ulcerative-require-Hemorrhage', 'Lung Diseases-affect-Death', 'Cerebral Infarction-associated-Cerebral Hemorrhage', 'Cerebral Hemorrhage-associated-Cerebral Infarction', 'Cerebral Infarction-associated-Dementia, Vascular', 'Dementia, Vascular-associated-Cerebral Infarction', 'Cerebral Infarction-associated-Arteriovenous Malformations', 'Arteriovenous Malformations-associated-Cerebral Infarction', 'Dementia-reveal-Peptic Ulcer', 'Cataract-found-Vision Disorders', 'Inflammation-show-Hemorrhage', 'Neoplasms-investigated-Colonic Neoplasms', 'Neoplasms-affected-Colonic Neoplasms', 'Hyperalgesia-tend-Inflammation', 'Hyperalgesia-give-Inflammation', 'Hyperalgesia-tend-Edema', 'Hyperalgesia-give-Edema', 'Hyperalgesia-tend-Muscular Disorders, Atrophic', 'Hyperalgesia-predominate-Muscular Disorders, Atrophic', 'Inflammation-predominate-Muscular Disorders, Atrophic', 'Edema-predominate-Muscular Disorders, Atrophic', 'Cerebrovascular Disorders-accord-Stroke', 'Cerebrovascular Disorders-accord-Dementia, Vascular', 'Diabetes Mellitus, Type 1-considered-Death', 'Thrombocytopenia-follow-Leukopenia', 'Thrombocytopenia-follow-Anemia', 'Femoral Fractures-analyzed-Fractures, Bone', 'Femoral Fractures-analyzed-Osteoporosis', 'Embolism-occur-Death', 'Death-suspect-Embolism', 'Neoplasms-offer-Colitis', 'Infections-mimic-Lupus Erythematosus, Discoid', 'Kidney Diseases-result-Hematuria', 'Kidney Diseases-result-Neoplasms', 'Cardiovascular Abnormalities-occur-Hearing Disorders', 'Immunologic Deficiency Syndromes-produce-Renal Insufficiency', 'Malabsorption Syndromes-contribute-Kidney Diseases', 'Parasitic Diseases-occur-Infections', 'Communicable Diseases-detected-Pancreatitis', 'Infections-cause-Neurodegenerative Diseases', 'Hypertension-undergo-Cardiovascular Diseases', 'Bone Neoplasms-lose-Osteoporotic Fractures', 'Sleep Wake Disorders-followed-Fatigue', 'Sleep Wake Disorders-followed-Sleepiness', 'Ovarian Neoplasms-stressed-Neoplasms', 'Death-certified-Poisoning', 'Diabetes Mellitus, Type 1-develop-Uremia', 'Hypercalcemia-include-Ovarian Diseases', 'Dermatomyositis-include-Ovarian Diseases', 'Spinocerebellar Degenerations-include-Ovarian Diseases', 'Headache Disorders, Secondary-suffer-Death', 'Headache Disorders, Secondary-suffer-Osteoporosis', 'Liver Diseases-associated-Malnutrition', 'Malnutrition-associated-Liver Diseases', 'Arthritis, Psoriatic-associated-Respiratory Insufficiency', 'Respiratory Insufficiency-associated-Arthritis, Psoriatic', 'Deafness-result-Heart Failure', 'Drug-Related Side Effects and Adverse Reactions-occur-Exanthema', 'Heart Diseases-implicated-Death', 'Neoplasms-implicated-Death', 'Alcoholism-implicated-Death', 'Death-interpreted-Obesity', 'Immunologic Deficiency Syndromes-underlie-Infections', 'Iatrogenic Disease-rise-Cross Infection', 'Paralysis-result-Infections', 'Muscle Weakness-seen-Poliomyelitis', 'Muscular Atrophy-seen-Poliomyelitis', 'Neoplasms-underlie-Carcinogenesis', 'Infections-contain-Neoplasms', 'Diarrhea-operated-Communicable Diseases', 'Infections-colonize-Spinal Injuries', 'Infections-colonize-Peripheral Vascular Diseases', 'Infections-colonize-Skin Ulcer', 'Hypertrophy, Left Ventricular-put-Death, Sudden', 'Ventricular Premature Complexes-put-Death, Sudden', 'Embolism, Cholesterol-include-Kidney Diseases', 'Death-fit-Seizures', 'Adrenal Insufficiency-recognised-Sleep Initiation and Maintenance Disorders', 'Leiomyoma-made-Leiomyosarcoma', 'Leiomyoma-simulate-Leiomyosarcoma', 'Uveitis-comprise-Inflammation', 'Uveitis-initiated-Soft Tissue Injuries', 'Hypertension-implicate-Stroke', 'Hypertension-implicate-Coronary Artery Disease', 'Hypokalemia-observed-Sexual Dysfunction, Physiological', 'Atherosclerosis-obstruct-Critical Illness', 'Atherosclerosis-produce-Myocardial Infarction', 'Critical Illness-produce-Myocardial Infarction', 'Vascular System Injuries-predispose-Ocular Hypertension', 'Vascular System Injuries-predispose-Retinal Vein Occlusion', 'Ocular Hypertension-predispose-Retinal Vein Occlusion', 'Ocular Hypertension-warranted-Retinal Vein Occlusion', 'Psychomotor Agitation-recognize-Heart Failure', 'Neoplasms-guide-Breast Neoplasms', 'Neoplasms-sever-Kidney Diseases', 'Wounds and Injuries-associated-Hip Fractures', 'Hip Fractures-associated-Wounds and Injuries', 'Neoplasms-increased-Breast Neoplasms', 'Hyperlipoproteinemia Type II-consider-Tendinopathy', 'Arteritis-diagnosed-Headache', 'Arteritis-diagnosed-Perceptual Disorders', 'Death-prove-Diabetes Mellitus', 'Drug Hypersensitivity Syndrome-avoid-Status Asthmaticus', 'Drug Hypersensitivity Syndrome-reviewed-Polyps', 'Drug Hypersensitivity Syndrome-reviewed-Nasal Obstruction', 'Drug Hypersensitivity Syndrome-reviewed-Sinusitis', 'Cough-associated-Pulmonary Disease, Chronic Obstructive', 'Pulmonary Disease, Chronic Obstructive-associated-Cough', 'Urinary Incontinence-associated-Muscular Atrophy', 'Muscular Atrophy-associated-Urinary Incontinence', 'Muscular Atrophy-occur-Urinary Incontinence', 'Liver Cirrhosis, Biliary-included-Liver Diseases', 'Osteomalacia-implicate-Fractures, Bone', 'Alcoholism-implicate-Fractures, Bone', 'Dementia-hospitalized-Alcoholism', 'Dementia-reported-Hydrocephalus', 'Alcoholism-reported-Hydrocephalus', 'Glaucoma-increase-Diabetes Mellitus', 'Intermittent Claudication-prevent-Blindness', 'Scoliosis-related-Joint Diseases', 'Scoliosis-appear-Joint Diseases', 'Meningeal Neoplasms-increase-Glioblastoma', 'Neuroma, Acoustic-increase-Glioblastoma', 'CADASIL-observed-Cerebrovascular Disorders', 'Gastrointestinal Hemorrhage-include-Neoplasms', 'Gastrointestinal Hemorrhage-used-Neoplasms', 'Angiodysplasia-represent-Gastrointestinal Hemorrhage', 'Sleep Apnea, Obstructive-linked-Obesity', 'Sleep Apnea, Obstructive-linked-Sleep Wake Disorders', 'Myasthenia Gravis-investigated-Autoimmune Diseases', 'Death-attribute-Heart Diseases', 'Death-attribute-Neoplasms', 'Neoplasm Metastasis-found-Thyroid Neoplasms', 'Neoplasm Metastasis-found-Thyroid Diseases', 'Fractures, Bone-suffer-Myocardial Infarction', 'Neoplasms-understand-Bone Neoplasms', 'Coma-resemble-Respiratory Insufficiency', 'Coma-resemble-Hypotension', 'Death-associated-Hip Dislocation', 'Hip Dislocation-associated-Death', 'Drug-Related Side Effects and Adverse Reactions-occur-Nephrotic Syndrome', 'Death-undergo-Lithiasis', 'Arteritis-affect-Polymyalgia Rheumatica', 'Osteoarthritis-characterised-Joint Diseases', 'Death-related-Myasthenic Syndromes, Congenital', 'Adenoma-induce-Cataract', 'Melanoma-excised-Cataract', 'Adenoma-mimic-Melanoma', 'Cataract-mimic-Melanoma', 'Chromosome Aberrations-found-Alzheimer Disease', 'Alzheimer Disease-found-Aneuploidy', 'Pulmonary Disease, Chronic Obstructive-suggested-Cardiovascular Abnormalities', 'Hypertension-seen-Proteinuria', 'Proteinuria-found-Urinary Tract Infections', 'Peptic Ulcer-decline-Death', 'Cystic Fibrosis-found-Renal Insufficiency', 'Infections-observed-Chronic Disease', 'Bundle-Branch Block-show-Lung Diseases, Obstructive', 'Hypotension-indicated-Intracranial Hemorrhages', 'Inflammatory Bowel Diseases-obtained-Intestinal Diseases', 'Myasthenia Gravis-mimic-Intermittent Claudication', 'Myasthenia Gravis-produce-Parotid Neoplasms', 'Myasthenia Gravis-produce-Pain', 'Intermittent Claudication-produce-Parotid Neoplasms', 'Intermittent Claudication-produce-Pain', 'Parotid Neoplasms-produce-Pain', 'Temporomandibular Joint Disorders-produce-Intermittent Claudication', 'Temporomandibular Joint Disorders-produce-Arthritis, Rheumatoid', 'Pain-produce-Arthritis, Rheumatoid', 'Intermittent Claudication-produce-Arthritis, Rheumatoid', 'Hypercalcemia-lead-Kidney Failure, Chronic', 'Calcinosis-lead-Kidney Failure, Chronic', 'Choroiditis-cause-Retinal Detachment', 'Thyroid Diseases-detected-Hypothyroidism', 'Femoral Neck Fractures-classified-Fractures, Bone', 'Bone Diseases, Metabolic-place-Fractures, Bone', 'Paralysis-show-Bell Palsy', 'Eye Diseases-demonstrate-Cataract', 'Eye Diseases-demonstrate-Blindness', 'Calcinosis-compared-Neoplasms', 'Paraplegia-occur-Neoplasms', 'Paraplegia-include-Neoplasm Metastasis', 'Cystic Fibrosis-result-Pneumothorax', 'Cystic Fibrosis-seen-Pneumothorax', 'Paraplegia-include-Prostatic Neoplasms', 'Rhabdomyolysis-fall-Cardiac Output, Low', 'Paraplegia-live-Paralysis', 'Neoplasms-known-Immunologic Deficiency Syndromes', 'Hyperparathyroidism-caused-Adenoma', 'Pneumothorax-include-Sclerosis', 'Pneumothorax-use-Sclerosis', 'Diabetes Mellitus-represent-Myopia', 'Alcoholism-progress-Atrophy', 'Angina Pectoris-culminate-Myocardial Infarction', 'Diabetic Ketoacidosis-occur-Diabetes Mellitus', 'Diabetic Ketoacidosis-presented-Coma', 'Hypertrophy-show-Muscular Disorders, Atrophic', 'Epilepsy-surround-Accidental Injuries', 'Epilepsy-become-Accidental Injuries', 'Hypothermia-treated-Coma', 'Sepsis-delay-Bacteremia', 'Infections-complicated-Osteomyelitis', 'Meningitis-follow-Wounds and Injuries', 'Tuberculosis-consider-Drug-Related Side Effects and Adverse Reactions', 'Pain, Postoperative-account-Death', 'Cardiac Complexes, Premature-account-Death', 'Heart Failure, Diastolic-decrease-Death', 'Diabetes Mellitus-ascribed-Hyperplasia', 'Dementia-produce-Neoplasms', 'Dementia-mimic-Stroke', 'Seizures-mimic-Neoplasms', 'Seizures-mimic-Stroke', 'Neoplasms-mimic-Stroke', 'Arterial Occlusive Diseases-produce-Nervous System Diseases', 'Arterial Occlusive Diseases-occur-Wounds, Nonpenetrating', 'Pain-make-Weight Gain', 'Atrophy-study-Alzheimer Disease', 'Hypertension-increase-Atrophy', 'Hypertension-become-Cardiomyopathy, Dilated', 'Anemia-ascertained-Death', 'Multiple Endocrine Neoplasia-found-Parathyroid Diseases', 'Parathyroid Diseases-found-Mucopolysaccharidosis II', 'Delirium-manifest-Stroke', 'Delirium-accompany-Stroke', 'Coronary Thrombosis-noted-Cardiomyopathies', 'Coronary Thrombosis-noted-Hemorrhage', 'Myocardial Infarction-manifest-Coronary Thrombosis', 'Coronary Thrombosis-lead-Cardiomyopathies', 'Disseminated Intravascular Coagulation-lead-Cardiomyopathies', 'Death-recognize-Disseminated Intravascular Coagulation', 'Hydrocephalus-account-Dementia', 'Cardiac Output, Low-decrease-Arteriosclerosis', 'Vision Disorders-cause-Glaucoma', 'Vision Disorders-cause-Anophthalmos', 'Headache Disorders, Secondary-begin-Ischemia', 'Colitis-begin-Headache Disorders, Secondary', 'Ischemia-determine-Colitis', 'Inflammatory Bowel Diseases-reported-Colitis', 'Glaucoma-treated-Ocular Hypertension', 'Ocular Hypertension-develop-Eye Diseases', 'Mitral Valve Insufficiency-identified-Heart Septal Defects, Atrial', 'Chemical and Drug Induced Liver Injury-shown-Jaundice', 'Chemical and Drug Induced Liver Injury-shown-Infections', 'Spondylosis-lead-Deglutition Disorders', 'Dementia-examined-Death', 'Colonic Neoplasms-come-Aneurysm', 'Colonic Neoplasms-occur-Colitis', 'Colonic Neoplasms-underlie-Aneurysm', 'Aneurysm-occur-Colitis', 'Colitis-related-Crohn Disease', 'Colorectal Neoplasms-perforated-Abscess', 'Death-reduced-Cold Injury', 'Fibrosis-indicate-Central Nervous System Neoplasms', 'Hypertension-needed-Cardiovascular Diseases', 'Carotid Artery Diseases-found-Syncope', 'Carotid Artery Diseases-found-Vertebrobasilar Insufficiency', 'Hypertension-attributed-Atherosclerosis', 'Anophthalmos-become-Hypertension', 'Glaucoma-caused-Ischemia', 'Osteoporotic Fractures-fail-Osteoporosis', 'Bone Diseases, Metabolic-reduce-Bone Neoplasms', 'Cross Infection-documented-Bacteremia', 'Pneumonia-found-Pneumococcal Infections', 'Glioblastoma-followed-Neoplasms', 'Glioblastoma-followed-Meningeal Neoplasms', 'Neoplasms-followed-Meningeal Neoplasms', 'Neoplasms-caused-Malnutrition', 'Malnutrition-studied-Neoplasms', 'Growth Disorders-studied-Neoplasms', 'Jaundice-found-Cholecystitis', 'Dementia-determined-Alzheimer Disease', 'Fibrosis-correspond-Nephritis, Interstitial', 'Fibrosis-correspond-Ovarian Neoplasms', 'Cardiovascular Diseases-lowering-Hypertension', 'Anemia, Hemolytic, Autoimmune-develop-Hemolysis', 'Anemia, Hemolytic, Autoimmune-develop-Hypothermia', 'Hemolysis-develop-Hypothermia', 'Neoplasms-detect-Hemorrhage', 'Thyrotoxicosis-cause-Bone Diseases, Metabolic', 'Hypokalemia-associated-Ventricular Premature Complexes', 'Ventricular Premature Complexes-associated-Hypokalemia', 'Infarction-reduce-Death', 'Brain Ischemia-produced-Vasospasm, Intracranial', 'Glaucoma-prevent-Blindness', 'Neoplasms-develop-Hemorrhage', 'Heat Stroke-defined-Fever', 'Sleep Initiation and Maintenance Disorders-work-Coronary Artery Disease', 'Sleep Initiation and Maintenance Disorders-work-Hypertension', 'Sleep Initiation and Maintenance Disorders-work-Hypercholesterolemia', 'Ulcer-study-Arthritis, Infectious', 'Diabetes Mellitus-induce-Cerebral Small Vessel Diseases', 'Pyelonephritis-identified-Bacteremia', 'Meningitis, Bacterial-appear-Bacteremia', 'Meningitis, Bacterial-appear-Shock, Septic', 'Dyspnea-provide-Death', 'Multiple Myeloma-include-Kidney Diseases', 'Airway Obstruction-include-Kidney Diseases', 'Genetic Diseases, Inborn-associated-Sleep Initiation and Maintenance Disorders', 'Sleep Initiation and Maintenance Disorders-associated-Genetic Diseases, Inborn', 'Werner Syndrome-believed-Genetic Diseases, Inborn', 'Werner Syndrome-develop-Leg Ulcer', 'Pneumococcal Infections-administered-Erythema', 'Alzheimer Disease-differ-Dementia, Vascular', 'Alzheimer Disease-differ-Cardiomyopathy, Dilated', 'Alzheimer Disease-differ-Atrophy', 'Otitis Externa-occur-Diabetes Mellitus', 'Endocarditis-avoid-Heart Failure', 'Death-result-Sepsis', 'Death-result-Hemorrhage', 'Aortic Aneurysm-associated-Aortic Valve Insufficiency', 'Aortic Valve Insufficiency-associated-Aortic Aneurysm', 'Cockayne Syndrome-describe-Kidney Diseases', 'Infections-identified-Bacteremia', 'Cardiotoxicity-take-Drug Overdose', 'Bacteremia-demonstrate-Airway Obstruction', 'Bacteremia-demonstrate-Communicable Diseases', 'Bacteremia-demonstrate-Abscess', 'Pyelonephritis-demonstrate-Airway Obstruction', 'Pyelonephritis-demonstrate-Communicable Diseases', 'Pyelonephritis-demonstrate-Abscess', 'Adenomatous Polyposis Coli-occur-Infections', 'Arbovirus Infections-produce-Hearing Loss', 'Parkinson Disease-rank-Heredodegenerative Disorders, Nervous System', 'Urinary Incontinence-associated-Acute Disease', 'Acute Disease-associated-Urinary Incontinence', 'Infections-develop-Dyspnea', 'Death-experience-Neurodegenerative Diseases', 'Meningitis, Listeria-seen-Meningitis', 'Meningitis, Listeria-occur-Skull Fractures', 'Meningitis-seen-Skull Fractures', 'Lung Neoplasms-resolved-Neoplasms', 'Myocardial Infarction-buy-Death', 'Angina Pectoris-survive-Ventricular Fibrillation', 'Werner Syndrome-lack-Kidney Diseases', 'Gastrointestinal Hemorrhage-evaluate-Hemorrhage', 'Death-suggest-Gastrointestinal Diseases', 'Cardiovascular Abnormalities-exist-Kidney Diseases', 'Precursor Cell Lymphoblastic Leukemia-Lymphoma-compared-Diarrhea', 'Precursor Cell Lymphoblastic Leukemia-Lymphoma-investigated-Diarrhea', 'Pneumococcal Infections-continue-Death', 'Infections-recognized-Seizures', 'Hypercholesterolemia-connected-Hepatitis C, Chronic', 'Ulcer-occur-Gastrointestinal Hemorrhage', 'Multiple Myeloma-suspected-Anemia', 'Multiple Myeloma-suspected-Pain', 'Fractures, Bone-impose-Wounds and Injuries', 'Corneal Edema-permit-Edema', 'Arthritis, Infectious-associated-Infections', 'Infections-associated-Arthritis, Infectious', 'Arthritis, Infectious-associated-Pneumonia', 'Pneumonia-associated-Arthritis, Infectious', 'Arthritis, Infectious-associated-Meningitis', 'Meningitis-associated-Arthritis, Infectious', 'Arthritis, Infectious-superimposed-Joint Diseases', 'Infections-associated-Arthritis', 'Arthritis-associated-Infections', 'Infections-superimposed-Joint Diseases', 'Pneumonia-associated-Arthritis', 'Arthritis-associated-Pneumonia', 'Pneumonia-superimposed-Joint Diseases', 'Meningitis-associated-Arthritis', 'Arthritis-associated-Meningitis', 'Meningitis-superimposed-Joint Diseases', 'Arthritis-superimposed-Joint Diseases', 'Drug-Related Side Effects and Adverse Reactions-studied-IgA Vasculitis', 'Infectious Mononucleosis-followed-Leukemia', 'Ventricular Premature Complexes-noted-Coronary Artery Disease', 'Ventricular Premature Complexes-appear-Ischemia', 'Bundle-Branch Block-associated-Heart Diseases', 'Heart Diseases-associated-Bundle-Branch Block', 'Anemia-compared-Death', 'Condylomata Acuminata-precede-Neoplasms', 'Neoplasms-observed-Condylomata Acuminata', 'Condylomata Acuminata-show-Neoplasms', 'Cholecystitis, Acute-prevented-Cholelithiasis', 'Head and Neck Neoplasms-develop-Neoplasms', 'Osteonecrosis-associated-Sleep Initiation and Maintenance Disorders', 'Sleep Initiation and Maintenance Disorders-associated-Osteonecrosis', 'Tuberculosis-lack-Fever', 'Arthritis, Rheumatoid-masquerade-Polymyalgia Rheumatica', 'Hyperparathyroidism-sought-Hypercalcemia', 'Sepsis-involve-Hypotension', 'Sepsis-occur-Hypotension', 'Sepsis-involve-Diabetes Mellitus', 'Sepsis-occur-Diabetes Mellitus', 'Adrenal Insufficiency-lead-Osteoporosis', 'Myocardial Infarction-determine-Death', 'Death-influence-Shock', 'Death-influence-Pulmonary Edema', 'Disease Progression-cause-Bone Diseases', 'Disease Progression-cause-Cranial Nerve Diseases', 'Bone Diseases-cause-Cranial Nerve Diseases', 'Diarrhea-found-Infections', 'Diabetes Mellitus-exist-Brain Diseases', 'Cerebral Infarction-found-Infarction', 'Infarction-found-Dementia', 'Hypokinesia-seen-Parkinsonian Disorders', 'Death-follow-Femoral Neck Fractures', 'Death-follow-Necrosis', 'Death-displace-Femoral Neck Fractures', 'Femoral Neck Fractures-displace-Necrosis', 'Peripheral Vascular Diseases-occur-Angina Pectoris', 'Peripheral Vascular Diseases-occur-Skin Neoplasms', 'Peripheral Vascular Diseases-occur-Diabetes Mellitus', 'Peripheral Vascular Diseases-occur-Neoplasms', 'Cholecystitis, Acute-associated-Fever', 'Fever-associated-Cholecystitis, Acute', 'Cholecystitis, Acute-associated-Leukocytosis', 'Leukocytosis-associated-Cholecystitis, Acute', 'Aging, Premature-followed-Death', 'Gynecomastia-developed-Orchitis', 'Orchitis-result-Gynecomastia', 'Hypertension-measured-Hypoxia', 'Hypertension-correlate-Hypercapnia', 'Death-develop-Jaundice', 'Sepsis-develop-Jaundice', 'Hemorrhage-evolve-Gangrene', 'Acute Pain-caused-Vascular Neoplasms', 'Arrhythmias, Cardiac-related-Headache Disorders, Secondary', 'Arrhythmias, Cardiac-known-Headache Disorders, Secondary', 'Arrhythmias, Cardiac-correlate-Headache Disorders, Secondary', 'Bradycardia-treated-Tachycardia', 'Obesity-associated-Pneumonia', 'Pneumonia-associated-Obesity', 'Inflammatory Bowel Diseases-attributed-Infections', 'Fractures, Bone-preferred-Infections', 'Hemorrhage-found-Hematoma', 'Kidney Diseases-manifested-Acute Kidney Injury', 'Kidney Diseases-preceded-Infections', 'Kidney Diseases-preceded-Pneumonia', 'Kidney Diseases-follow-Infections', 'Death, Sudden-include-Coronary Artery Disease', 'Coronary Artery Disease-terminated-Death, Sudden', 'Syncope-carry-Heart Block', 'Psoriasis-found-Epilepsy, Complex Partial', 'Psoriasis-trigger-Infections', 'Epilepsy, Complex Partial-trigger-Infections', 'Stroke-distributed-Hemorrhage', 'Infections-trigger-Pruritus', 'Obesity-subjected-Hyperphagia', 'Hypertension-subjected-Hyperphagia', 'Heart Arrest-include-Pneumococcal Infections', 'Anemia-include-Pneumococcal Infections', 'Multiple Myeloma-include-Pneumococcal Infections', 'Heterotaxy Syndrome-include-Pneumococcal Infections', 'Nephrotic Syndrome-include-Pneumococcal Infections', 'Hypertension-likened-Cushing Syndrome', 'Urinary Incontinence-treat-Brain Injury, Chronic', 'Urinary Incontinence-suffer-Brain Injury, Chronic', 'Communicable Diseases-produce-Embolism', 'Arthritis-defined-Arthritis, Psoriatic', 'Rupture-become-Aneurysm', 'Aneurysm-cause-Pain', 'Aneurysm-produce-Embolism', 'Aneurysm-produce-Thrombosis', 'Aneurysm-produce-Rupture', 'Pain-produce-Embolism', 'Pain-produce-Thrombosis', 'Pain-produce-Rupture', 'Atrophy-prevent-Osteoporosis', 'Angiodysplasia-recognized-Gastrointestinal Hemorrhage', 'Chest Pain-exclude-Angina Pectoris', 'Angiodysplasia-result-Hemorrhage', 'Angiodysplasia-cause-Infarction', 'Hemorrhage-cause-Infarction', 'Abnormalities, Drug-Induced-recur-Hemorrhage', 'Sepsis-ensue-Death', 'Sepsis-ensue-Heart Failure', 'Sepsis-ensue-Arrhythmias, Cardiac', 'Sepsis-ensue-Stroke', 'Sepsis-ensue-Myocardial Infarction', 'Sepsis-ensue-Blood Coagulation Disorders', 'Heart Failure-linked-Immunologic Deficiency Syndromes', 'Death-ensue-Heart Failure', 'Death-ensue-Arrhythmias, Cardiac', 'Death-ensue-Stroke', 'Death-ensue-Blood Coagulation Disorders', 'Alzheimer Disease-differentiated-Parkinson Disease', 'Fractures, Bone-develop-Ankylosis', 'Pain-precede-Paralysis', 'Death-qualify-Wounds and Injuries', 'Hyperplasia-show-Kidney Failure, Chronic', 'Seizures-noted-Myoclonus', 'Cerebrovascular Disorders-found-Seizures', 'Seizures-noted-Epilepsy', 'Hypopigmentation-associated-Lentigo', 'Lentigo-associated-Hypopigmentation', 'Otitis Media-give-Hearing Loss', 'Otitis Media-combine-Hearing Loss', 'Pain-prolong-Death', 'Pain-prolong-Dehydration', 'Neurologic Manifestations-produce-Anorexia', 'Kidney Diseases-associated-Renal Insufficiency', 'Renal Insufficiency-associated-Kidney Diseases', 'Kidney Diseases-involve-Multiple Myeloma', 'Kidney Diseases-involve-Renal Insufficiency', 'Pain-describe-Osteoarthritis', 'Pain-discuss-Neuralgia', 'Back Pain-include-Pain', 'Neuralgia-seen-Pain', 'Tonsillitis-occur-Toxoplasmosis', 'Body Weight-classify-Neoplasms', 'Joint Diseases-confirm-Inflammation', 'Gout-covered-Inflammation', 'Hypotension-associated-Nervous System Diseases', 'Nervous System Diseases-associated-Hypotension', 'Hypotension-associated-Lymphoma', 'Lymphoma-associated-Hypotension', 'Hypotension-occur-Lymphoma', 'Athetosis-longstand-Amyotrophic Lateral Sclerosis', 'Anus Neoplasms-cause-Colonic Pseudo-Obstruction', 'Alzheimer Disease-obtained-Death', 'Cerebral Hemorrhage-discussed-Aortic Diseases', 'Aneurysm-seen-Hypertension', 'Stroke-appear-Hypotension', 'Stroke-appear-Hemorrhage', 'Stroke-appear-Pulmonary Embolism', 'Hypotension-appear-Heart Failure', 'Hypotension-appear-Hemorrhage', 'Hypotension-appear-Pulmonary Embolism', 'Hypotension-followed-Bradycardia', 'Bradycardia-induced-Heart Block', 'Urinary Bladder Neoplasms-undertaken-Rett Syndrome', 'Coronary Artery Disease-associated-Death, Sudden, Cardiac', 'Death, Sudden, Cardiac-associated-Coronary Artery Disease', 'Death-caused-Intracranial Embolism', 'Death-occur-Stenosis, Pulmonary Artery', 'Intracranial Embolism-caused-Stenosis, Pulmonary Artery', 'Brain Diseases-reflect-Dementia', 'Intracranial Embolism-caused-Atrial Fibrillation', 'Dementia-reflect-Neurodegenerative Diseases', 'Parkinson Disease-elevate-Hypertension', 'Sleep Wake Disorders-associated-Narcolepsy', 'Narcolepsy-associated-Sleep Wake Disorders', 'Parkinson Disease-increase-Phenylketonurias', 'Sleep Wake Disorders-associated-Dyssomnias', 'Dyssomnias-associated-Sleep Wake Disorders', 'Hypertension-increase-Phenylketonurias', 'Nerve Degeneration-attributed-Heart Arrest', 'Heart Failure-compare-Dyspnea', 'Heart Failure-suffer-Dyspnea', 'Lung Diseases-compare-Dyspnea', 'Lung Diseases-suffer-Dyspnea', 'Neoplasms-show-Ameloblastoma', 'Myocardial Infarction-complicated-Heart Failure', 'Dementia-seen-Alzheimer Disease', 'Femoral Neck Fractures-follow-Death', 'Femoral Neck Fractures-follow-Wounds and Injuries', 'Ventricular Septal Rupture-repaired-Aneurysm', 'Leukemia, Lymphoid-subjected-Splenomegaly', 'Nausea-followed-Diarrhea', 'Fever-followed-Nausea', 'Diarrhea-followed-Vomiting', 'Fever-followed-Vomiting', 'Coronary Artery Disease-examined-Arrhythmias, Cardiac', 'Neoplasms-suggest-Carcinogenesis', 'Neoplasms-produce-Adenocarcinoma, Mucinous', 'Neoplasms-produce-Hypercalcemia', 'Adenoma-provide-Neoplasms', 'Psychoses, Substance-Induced-reduce-Nausea', 'Immunoglobulin Light-chain Amyloidosis-result-Cerebral Hemorrhage', 'Cerebral Amyloid Angiopathy-regarded-Stroke', 'Seizures-performed-Ventricular Fibrillation', 'Cardiac Output, Low-fall-Alzheimer Disease', 'Lung Diseases-coexist-Common Cold', 'Granulomatosis with Polyangiitis-characterized-Vasculitis, Central Nervous System', 'Glaucoma-coexist-Common Cold', 'Medulloblastoma-develop-Neoplasm Metastasis', 'Alzheimer Disease-account-Common Cold', 'Cholecystitis, Acute-consist-Infections', 'Endocarditis, Bacterial-present-Fever', 'Tuberculosis-present-Fever', 'Arteritis-present-Fever', 'Arrhythmias, Cardiac-lead-Cardiac Output, Low', 'Nervous System Diseases-lead-Cardiac Output, Low', 'Cataract-removed-Glaucoma', 'Cataract-compared-Glaucoma', 'Cardiomyopathy, Hypertrophic-tend-Hypertension', 'Cardiomyopathy, Hypertrophic-acquired-Hypertension', 'Blister-evaluated-Death', 'Acute Disease-operated-Hematoma, Subdural', 'Acute Disease-operated-Nervous System Diseases', 'Hematoma, Subdural-operated-Nervous System Diseases', 'Lung Diseases-terminated-Atrioventricular Block', 'Glucose Metabolism Disorders-associated-Neoplasms', 'Neoplasms-associated-Glucose Metabolism Disorders', 'Respiratory Tract Diseases-use-Death', 'Gastrointestinal Diseases-suggest-Malabsorption Syndromes', 'Pulmonary Disease, Chronic Obstructive-recorded-Aspergillosis', 'Venous Thrombosis-underlie-Atherosclerosis', 'Venous Thrombosis-develop-Hemorrhage', 'Atherosclerosis-develop-Hemorrhage', 'Kashin-Beck Disease-cause-Arthritis', 'Amyloidosis-associated-Atrial Fibrillation', 'Atrial Fibrillation-associated-Amyloidosis', 'Atherosclerosis-confirmed-Embolism, Cholesterol', 'Atherosclerosis-confirmed-Renal Insufficiency', 'Renal Insufficiency-develop-Atherosclerosis', 'Vascular Calcification-increase-Kidney Failure, Chronic', 'Colitis, Ischemic-described-Gangrene', 'Ischemia-considered-Colitis', 'Endarteritis-characterized-Necrosis', 'Renal Insufficiency-occur-Hypertension, Malignant', 'Neoplasms-exclude-Ulcer', 'Neoplasm Metastasis-found-Neoplasms', 'Diabetes Mellitus-contribute-Stomach Diseases', 'Nervous System Diseases-caused-Death', 'Pheochromocytoma-antedate-Retinal Diseases', 'Skin Diseases-develop-Xeroderma Pigmentosum', 'Stomach Neoplasms-afflict-Mucositis', 'Fractures, Bone-include-Vascular System Injuries', 'Infections-ensue-Osteomyelitis', 'Fractures, Bone-justify-Infections', 'Angina Pectoris-proceed-Death', 'Aneurysm-known-Rupture', 'Death-lose-Postpartum Hemorrhage', 'Polymyalgia Rheumatica-manifest-Arthritis, Rheumatoid', 'Synovitis-resemble-Arthritis, Rheumatoid', 'Polymyalgia Rheumatica-resemble-Arthritis, Rheumatoid', 'Brain Infarction-found-Alzheimer Disease', 'Alzheimer Disease-differentiate-Cerebrovascular Disorders', 'Alzheimer Disease-prove-Myocardial Infarction', 'Dementia-differentiate-Cerebrovascular Disorders', 'Dementia-prove-Myocardial Infarction', 'Myocardial Infarction-develop-Hemiplegia', 'Cerebrovascular Disorders-prove-Myocardial Infarction', 'Myocardial Infarction-develop-Stroke', 'Osteonecrosis-occur-Anemia, Sickle Cell', 'Shock-appear-Hypovolemia', 'Diabetes Mellitus-yield-Werner Syndrome', 'Cardiomyopathy, Dilated-cause-Epilepsy', 'Hypertension-result-Sleep Initiation and Maintenance Disorders', 'Giant Cell Arteritis-prevent-Blindness', 'Anemia, Hemolytic, Congenital Nonspherocytic-suffer-Infections', 'Giant Cell Arteritis-prevent-Death', 'Alzheimer Disease-prove-Brain Diseases', 'Myocardial Infarction-reoperated-Hemorrhage', 'Cardiovascular Diseases-recover-Myocardial Infarction', 'Diverticulum-control-Hemorrhage', 'Asthma-cause-Eosinophilia', 'Eosinophilia-cause-Bronchitis', 'Eosinophilia-cause-Airway Obstruction', 'Death-use-Lip Diseases', 'Leukoplakia-compare-Neoplasms', 'Ophthalmoplegia-suggest-Aneurysm', 'Headache Disorders, Secondary-considered-Neoplasms', 'Cardiovascular Diseases-reveal-Cardiomyopathy, Hypertrophic', 'Cardiovascular Diseases-reveal-Hypertension', 'Cardiovascular Diseases-occur-Calcinosis', 'Cardiovascular Diseases-include-Endocarditis, Bacterial', 'Cardiovascular Diseases-include-Atrioventricular Block', 'Calcinosis-include-Endocarditis, Bacterial', 'Calcinosis-include-Atrioventricular Block', 'Death-confirm-Dementia', 'Death-confirm-Alzheimer Disease', 'Acanthosis Nigricans-associated-Neoplasms', 'Neoplasms-associated-Acanthosis Nigricans', 'Papilloma-examined-Neoplasms', 'Neoplasms-reveal-Carcinoma, Squamous Cell', 'Glomerulonephritis-related-Streptococcal Infections', 'Hypoaldosteronism-progress-Kidney Diseases', 'Ureteral Obstruction-caused-Neoplasms', 'Calcinosis-associated-Intracranial Embolism', 'Intracranial Embolism-associated-Calcinosis', 'Lupus Erythematosus, Systemic-modify-Lung Diseases', 'Lupus Erythematosus, Systemic-modify-Lymphatic Diseases', 'Lupus Erythematosus, Systemic-modify-Raynaud Disease', 'Neoplasms-found-Vulvar Neoplasms', 'Heart Failure-described-Mitral Valve Prolapse', 'Anemia, Megaloblastic-occur-Death', 'Heart Failure-associated-Pleural Effusion', 'Pleural Effusion-associated-Heart Failure', 'Death-cause-Osteoporosis', 'Chronic Disease-cause-Osteoporosis', 'Chronic Disease-suffer-Death, Sudden', 'Osteoporosis-suffer-Death, Sudden', 'Cholecystitis, Acute-performed-Gangrene', 'Sexually Transmitted Diseases-carried-Dementia', 'Stomach Ulcer-treated-Heart Failure', 'Stomach Ulcer-treated-Hypertension', 'Headache Disorders, Secondary-heal-Ulcer', 'Coronary Artery Disease-diagnosed-Angina Pectoris', 'Coronary Artery Disease-diagnosed-Heart Diseases', 'Calcinosis-represent-Tendinopathy', 'Gastroesophageal Reflux-remain-Hypotension', 'Death, Sudden-reported-Neoplasms', 'Death, Sudden-live-Tachycardia, Atrioventricular Nodal Reentry', 'Neoplasms-live-Tachycardia, Atrioventricular Nodal Reentry', 'Tachycardia, Atrioventricular Nodal Reentry-present-Heart Block', 'Tachycardia, Atrioventricular Nodal Reentry-present-Syncope', 'Ocular Hypertension-decrease-Communicable Diseases', 'Melanoma-decrease-Communicable Diseases', 'Arteritis-remembered-Headache', 'Macular Degeneration-resemble-Retinal Diseases', 'Headache-caused-Intracranial Arterial Diseases', 'Liver Failure-reflect-Breast Neoplasms', 'Diabetes Mellitus-reported-Kidney Diseases', 'Diabetes Mellitus-make-Nervous System Diseases', 'Diabetes Mellitus-make-Dehydration', 'Acute Kidney Injury-reported-Kidney Diseases', 'Acute Kidney Injury-develop-Nervous System Diseases', 'Acute Kidney Injury-develop-Cardiovascular Diseases', 'Acute Kidney Injury-develop-Dehydration', 'Kidney Diseases-reported-Retinal Diseases', 'Diabetes Mellitus-complicated-Cardiovascular Diseases', 'Kidney Diseases-make-Nervous System Diseases', 'Kidney Diseases-make-Cardiovascular Diseases', 'Kidney Diseases-make-Dehydration', 'Retinal Diseases-make-Nervous System Diseases', 'Retinal Diseases-make-Cardiovascular Diseases', 'Retinal Diseases-make-Dehydration', 'Mitral Valve Stenosis-belong-Calcinosis', 'Constriction, Pathologic-belong-Calcinosis', 'Diabetes Mellitus-detect-Acute Kidney Injury', 'Breast Neoplasms-develop-Endocrine System Diseases', 'Chondrocalcinosis-known-Hyperparathyroidism', 'Hypertension-controlled-Death', 'Osteoporosis-induce-Bone Neoplasms', 'Thrombosis-found-Cardiomyopathies', 'Thrombosis-found-Hemorrhage', 'Thrombosis-found-Myocardial Infarction', 'Thrombosis-found-Necrosis', 'Disseminated Intravascular Coagulation-complicated-Heart Diseases', 'Heart Diseases-rank-Hypertension', 'Stroke-related-Heart Diseases', 'Spinal Cord Injuries-result-Quadriplegia', 'Spinal Cord Injuries-lead-Death', 'Paraplegia-lead-Death', 'Quadriplegia-lead-Death', 'Chorea-induce-Dyskinesias', 'Cerebral Infarction-uncomplicated-Stroke', 'Stroke-uncomplicated-Heart Diseases', 'Edema-attributed-Heart Diseases', 'Dyspnea-attributed-Heart Diseases', 'Tachycardia-attributed-Heart Diseases', 'Pain-decrease-Edema', 'Pain-decrease-Musculoskeletal Diseases', 'Pain-improve-Muscle Weakness', 'Pain-improve-Ataxia', 'Ocular Hypertension-prompt-Cataract', 'Cardiovascular Diseases-produce-Rheumatic Diseases', 'Aneurysm-dissect-Wounds and Injuries', 'Aneurysm-initiated-Wounds and Injuries', 'Death-suffer-Hemorrhage', 'Esophageal Achalasia-present-Deglutition Disorders', 'Esophageal Achalasia-mistaken-Neoplastic Syndromes, Hereditary', 'Urinary Bladder, Overactive-suggest-Airway Obstruction', 'Cartilage Diseases-derived-Arthritis', 'Malnutrition-assess-Malabsorption Syndromes', 'Hemorrhage-cause-Neurologic Manifestations', 'Femoral Neck Fractures-investigated-Osteomalacia', 'Neoplasms-identify-Hemorrhage', 'Bradycardia-represent-Sick Sinus Syndrome', 'Bradycardia-associated-Intracranial Arteriosclerosis', 'Intracranial Arteriosclerosis-associated-Bradycardia', 'Sick Sinus Syndrome-associated-Intracranial Arteriosclerosis', 'Intracranial Arteriosclerosis-associated-Sick Sinus Syndrome', 'Sick Sinus Syndrome-include-Motor Neuron Disease', 'Thyroid Neoplasms-result-Carcinoma, Giant Cell', 'Coinfection-exhibit-Hereditary Breast and Ovarian Cancer Syndrome', 'Myoclonus-tested-Stroke', 'Pericarditis-include-Myocardial Infarction', 'Pericarditis-include-Renal Insufficiency', 'Pericarditis-include-Arthritis, Rheumatoid', 'Pericarditis-include-Hypothyroidism', 'Fractures, Bone-show-Brain Injury, Chronic', 'Dermatitis-seen-Granuloma', 'Urinary Incontinence-Overflow-Prostatitis', 'Urinary Incontinence-result-Prostatitis', 'Urinary Incontinence-Overflow-Nervous System Diseases', 'Urinary Incontinence-result-Nervous System Diseases', 'Aneurysm-interpreted-Brain Diseases', 'Heart Failure-follow-Endocarditis', 'Endocarditis-improve-Heart Failure', 'Heart Diseases-report-Hypertension', 'Heart Diseases-report-Diabetes Mellitus', 'Diabetes Mellitus-report-Hypertension', 'Arthritis-presented-Gonorrhea', 'Hearing Disorders-lead-Neoplasms', 'Siderosis-associated-Parkinson Disease, Secondary', 'Parkinson Disease, Secondary-associated-Siderosis', 'Smooth Muscle Tumor-induce-Stroke', 'Adenocarcinoma-admitted-Neoplasms', 'Renal Insufficiency, Chronic-take-Adenocarcinoma', 'Renal Insufficiency, Chronic-see-Nephritis, Interstitial', 'Renal Insufficiency, Chronic-see-Aneurysm', 'Adenocarcinoma-see-Nephritis, Interstitial', 'Adenocarcinoma-lead-Aneurysm', 'Nephritis, Interstitial-see-Aneurysm', 'Aortic Diseases-considered-Cerebral Hemorrhage', 'Aortic Diseases-considered-Dementia', 'Diabetes Mellitus-occur-Nervous System Diseases', 'Diabetes Mellitus-occur-Radiculopathy', 'Nervous System Diseases-occur-Radiculopathy', 'Death-came-Chronic Disease', 'Bronchopneumonia-cause-Death', 'Bronchopneumonia-cause-Brain Injury, Chronic', 'Death-cause-Brain Injury, Chronic', 'Death-found-Brain Injury, Chronic', 'Stroke-become-Hypertension', 'Hypertension-predispose-Cerebrovascular Disorders', 'Hypertension-predispose-Intracranial Arteriosclerosis', 'Death-caused-Coronary Artery Disease', 'Seizures, Febrile-followed-Seizures', 'Hypotension-indicated-Hypertension', 'Hypotension-indicated-Heart Failure', 'Hypotension-indicated-Cerebral Hemorrhage', 'Hypotension-offered-Hypertension', 'Hypotension-indicated-Angina Pectoris', 'Hypotension-indicated-Headache', 'Hypertension-accompanied-Angina Pectoris', 'Hypertension-accompanied-Headache', 'Dementia-stressed-Cerebrovascular Disorders', 'Dementia-arise-Metabolic Diseases', 'Neurodegenerative Diseases-stressed-Cerebrovascular Disorders', 'Sleep Wake Disorders-treat-Rheumatic Diseases', 'Hydrocephalus-stressed-Cerebrovascular Disorders', 'Dementia-differentiate-Cerebral Hemorrhage', 'Diabetic Angiopathies-include-Diabetes Mellitus', 'Coronary Artery Disease-decrease-Death, Sudden', 'Coronary Artery Disease-decrease-Arrhythmias, Cardiac', 'Ovarian Neoplasms-associated-Endometrial Neoplasms', 'Endometrial Neoplasms-associated-Ovarian Neoplasms', 'Endometrial Neoplasms-found-Obesity', 'Endometrial Neoplasms-associated-Hypothalamic Diseases', 'Hypothalamic Diseases-associated-Endometrial Neoplasms', 'Endometrial Neoplasms-associated-Hyperkinesis', 'Hyperkinesis-associated-Endometrial Neoplasms', 'Endometrial Neoplasms-associated-Trophoblastic Neoplasms', 'Trophoblastic Neoplasms-associated-Endometrial Neoplasms', 'Endometrial Neoplasms-observe-Trophoblastic Neoplasms', 'Hypothalamic Diseases-observe-Trophoblastic Neoplasms', 'Hyperkinesis-observe-Trophoblastic Neoplasms', 'Respiration Disorders-constitute-Death', 'Airway Obstruction-confirm-Emphysema', 'Pneumonia-account-Respiration Disorders', 'Myocardial Infarction-acquire-Heart Failure', 'Angina Pectoris-acquire-Heart Failure', 'Corneal Dystrophies, Hereditary-belong-Sleep Deprivation', 'Leukemia-differ-Leukemia, Monocytic, Acute', 'Corneal Dystrophies, Hereditary-belong-Vitreous Hemorrhage', 'Heart Diseases-found-Stenosis, Pulmonary Artery', 'Heart Diseases-found-Hypovolemia', 'Ventricular Dysfunction, Left-reveal-Stenosis, Pulmonary Artery', 'Ventricular Dysfunction, Left-reveal-Heart Diseases', 'Hypovolemia-reveal-Heart Diseases', 'Stenosis, Pulmonary Artery-reveal-Heart Diseases', 'Gastrointestinal Hemorrhage-complicated-Heart Diseases', 'Dilatation, Pathologic-resected-Neoplasms', 'Dilatation, Pathologic-resected-Hemorrhage', 'Neoplasms-resected-Hemorrhage', 'Dilatation, Pathologic-caused-Airway Obstruction', 'Rheumatic Diseases-presented-Osteoarthritis', 'Rheumatic Diseases-presented-Arthritis, Rheumatoid', 'Rheumatic Diseases-presented-Polymyalgia Rheumatica', 'Rheumatic Diseases-presented-Synovitis', 'Xeroderma Pigmentosum-develop-Nervous System Diseases', 'Xeroderma Pigmentosum-develop-Death', 'Nervous System Diseases-develop-Death', 'Neoplasms-contribute-Mesenteric Ischemia', 'Carcinoma-followed-Dystonia', 'Death, Sudden-occur-Death', 'Death-increase-Alcoholism', 'Alcoholism-increase-Death', 'Hypertrophy-show-Fibrosis', 'Kidney Failure, Chronic-develop-Atherosclerosis', 'Death-afflicted-Chronic Disease', 'Epidural Neoplasms-reduce-Edema', 'Epidural Neoplasms-reduce-Inflammation', 'Dementia, Vascular-distinguish-Alzheimer Disease', 'Mucopolysaccharidosis III-take-Psychomotor Disorders', 'Heart Diseases-correlate-Atrial Fibrillation', 'Heart Diseases-correlate-Bundle-Branch Block', 'Back Pain-look-Neurodegenerative Diseases', 'Neoplasms-attributed-Prostatic Neoplasms', 'Nervous System Diseases-include-Hypertension', 'Dementia-complicated-Cerebrovascular Disorders', 'Dementia-complicated-Hemorrhage', 'Cerebrovascular Disorders-complicated-Alzheimer Disease', 'Hemorrhage-complicated-Alzheimer Disease', 'Urinary Tract Infections-found-Malnutrition', 'Neoplasms-removed-Inflammatory Bowel Diseases', 'Osteoporosis-reflect-Femoral Neck Fractures', 'Osteoporosis-reflect-Fractures, Bone', 'Leukemia-registered-Neoplasms', 'Leukemia-cause-Neoplasms', 'Liver Diseases-affect-Neoplasm Metastasis', 'Neoplasm Metastasis-affect-Liver Cirrhosis', 'Immunologic Deficiency Syndromes-result-Osteoporosis', 'Immunologic Deficiency Syndromes-associated-Crush Injuries', 'Crush Injuries-associated-Immunologic Deficiency Syndromes', 'Renal Insufficiency-precipitated-Heart Failure', 'Renal Insufficiency-precipitated-Chest Pain', 'Renal Insufficiency-precipitated-Stroke', 'Pain-excluded-Angina Pectoris', 'Pain-excluded-Ventricular Dysfunction, Left', 'Tuberculosis-show-Asthma', 'Asthma-found-Pharyngeal Diseases', 'Asthma-found-Anophthalmos', 'Rhinitis, Allergic, Seasonal-found-Pharyngeal Diseases', 'Rhinitis, Allergic, Seasonal-found-Anophthalmos', 'Neoplasms-contain-Metaplasia', 'Epilepsy-follow-Cerebrovascular Disorders', 'Neoplasms-contain-Adenocarcinoma', 'Epilepsy-follow-Hemiplegia', 'Neoplasms-contain-Osteosarcoma', 'Cardiomyopathy, Hypertrophic-seen-Airway Obstruction', 'Pain-destroyed-Neoplasms', 'Cardiomyopathy, Hypertrophic-seen-Hypertrophy', 'Cardiomyopathy, Dilated-recognized-Hypertrophy', 'Cardiomyopathy, Dilated-recognized-Heart Failure', 'Airway Obstruction-seen-Hypertrophy', 'Cardiomyopathy, Dilated-seen-Hypertrophy', 'Cardiomyopathy, Dilated-promoted-Hypertrophy', 'Death-replaced-Airway Obstruction', 'Cardiomyopathy, Hypertrophic-replaced-Airway Obstruction', 'Hypertrophy-replaced-Airway Obstruction', 'Cardiomyopathy, Hypertrophic-contribute-Death, Sudden', 'Cardiomyopathy, Hypertrophic-contribute-Fibrosis', 'Atrial Fibrillation-observed-Myocardial Infarction', 'Heart Diseases-indicate-Obesity', 'Drug Hypersensitivity-induced-Ischemia', 'Ischemia-induced-Cerebrovascular Disorders', 'Polymyalgia Rheumatica-seen-Weight Loss', 'Polymyalgia Rheumatica-seen-Fever', 'Polymyalgia Rheumatica-seen-Muscle Weakness', 'Polymyalgia Rheumatica-seen-Fatigue', 'Scoliosis-lead-Atherosclerosis', 'Biliary Tract Diseases-operated-Death', 'Vascular Calcification-result-Death', 'Glomerulonephritis-occur-Infections', 'Kidney Diseases-found-Vasculitis', 'Splenic Diseases-found-Vasculitis', 'Bundle-Branch Block-shortened-Hypertension', 'Fibrosis-cause-Hypertension', 'Pulmonary Alveolar Proteinosis-follow-Hypoxia', 'Psittacosis-carried-Fever', 'Neoplasms-survive-Neoplasm Metastasis', 'Osteoporosis-caused-Kidney Failure, Chronic', 'Death-approach-Ventricular Fibrillation', 'Rupture-include-Intracranial Aneurysm', 'Hypertension-include-Intracranial Aneurysm', 'Aneurysm-include-Intracranial Aneurysm', 'Rupture-include-Aneurysm', 'Liver Cirrhosis-sustain-Myocardial Infarction', 'Spinal Cord Diseases-attributed-Atherosclerosis', 'Plaque, Atherosclerotic-cause-Ischemia', 'Plaque, Atherosclerotic-exist-Infarction', 'Hyperparathyroidism, Primary-separated-Hypercalcemia', 'Osteonecrosis-give-Femoral Neck Fractures', 'Respiratory Tract Infections-precede-Pericarditis', 'Meningeal Neoplasms-show-Neoplasms', 'Hypothyroidism-treated-Thyrotoxicosis', 'Contracture-develop-Skin Abnormalities', 'Death-caused-Dementia, Vascular', 'Dementia, Vascular-caused-Myocardial Infarction', 'Anemia, Hemolytic-associated-Reticulocytosis', 'Reticulocytosis-associated-Anemia, Hemolytic', 'Cerebral Infarction-evaluated-Stroke', 'Neuralgia-afford-Pain', 'Rheumatic Diseases-occur-Low Back Pain', 'Cold Injury-studied-Leukemia', 'Pain-relieve-Infarction', 'Pain-accelerate-Atherosclerosis', 'Pain-relieve-Death', 'Neurodegenerative Diseases-predispose-Thrombosis', 'Peripheral Vascular Diseases-undergo-Mesenteric Ischemia', 'Periodontal Diseases-support-Wounds and Injuries', 'Periodontal Diseases-alter-Osteosarcoma', 'Wounds and Injuries-alter-Osteosarcoma', 'Skin Diseases-exhibit-Carcinogenesis', 'Xeroderma Pigmentosum-exhibit-Carcinogenesis', 'Death-occur-Intellectual Disability', 'Death-occur-Alcoholism', 'Intellectual Disability-occur-Alcoholism', 'Hematoma-transformed-Empyema, Subdural', 'Thrombosis-seen-Fatty Liver', 'Thrombosis-lead-Calcinosis', 'Urinary Bladder Neoplasms-associated-Urinary Bladder Calculi', 'Urinary Bladder Calculi-associated-Urinary Bladder Neoplasms', 'Osteoporotic Fractures-gastrectomize-Liver Cirrhosis', 'Malnutrition-treated-Anemia, Megaloblastic', 'Lymphoma-become-Infertility, Female', 'Headache Disorders, Secondary-considered-Tuberculosis', 'Hemorrhage-recognized-Peptic Ulcer', 'Critical Illness-treat-Heart Arrest', 'Critical Illness-treat-Hemorrhage', 'Cardiac Output, Low-blamed-Arrhythmias, Cardiac', 'Hypotension-blamed-Arrhythmias, Cardiac', 'Hypoxia-blamed-Arrhythmias, Cardiac', 'Hyperparathyroidism, Primary-recognized-Lithiasis', 'Hyperparathyroidism, Primary-recognized-Osteitis Fibrosa Cystica', 'Atrial Fibrillation-associated-Cardiomyopathies', 'Cardiomyopathies-associated-Atrial Fibrillation', 'Headache-result-Heart Failure', 'Headache-result-Ischemia', 'Atrial Fibrillation-followed-Atrial Flutter', 'Vascular Headaches-associated-Giant Cell Arteritis', 'Giant Cell Arteritis-associated-Vascular Headaches', 'Atrial Fibrillation-followed-Tachycardia, Supraventricular', 'Anastomotic Leak-remain-Death', 'Arrhythmias, Cardiac-followed-Atrial Flutter', 'Arrhythmias, Cardiac-followed-Tachycardia, Supraventricular', 'Stomach Neoplasms-used-Neoplasms', 'Calcinosis-associated-Retinal Arterial Macroaneurysm', 'Retinal Arterial Macroaneurysm-associated-Calcinosis', 'Calcinosis-seen-Multiple Chronic Conditions', 'Colonic Neoplasms-bear-Death', 'Myocardial Infarction-experience-Pain', 'Pain-combined-Dyspnea', 'Dyspnea-associated-Pain', 'Pain-associated-Dyspnea', 'Dyspnea-unaccompanied-Pain', 'Dyspnea-herald-Infarction', 'Pain-herald-Infarction', 'Jaundice-facilit-Airway Obstruction', 'Neoplasms-search-Pain', 'Neoplasms-proceed-Weight Loss', 'Pain-proceed-Weight Loss', 'Polymyalgia Rheumatica-develop-Sarcoidosis', 'Polymyalgia Rheumatica-develop-Thyroiditis, Autoimmune', 'Polymyalgia Rheumatica-develop-Headache Disorders, Secondary', 'Dystonia-discovered-Breast Neoplasms', 'Neoplasms-progress-Vaginal Diseases', 'Parkinsonian Disorders-show-Weight Loss', 'Neoplasms-occur-Adenomatous Polyposis Coli', 'Neoplasms-found-Polyps', 'Cerebrovascular Disorders-live-Dementia', 'Urinary Incontinence-live-Dementia', 'Hypertension-treat-Brain Ischemia', 'Hypertension-treat-Hypotension', 'Hydrocephalus-exhibit-Psychomotor Disorders', 'Nervous System Diseases-regarded-Hydrocephalus', 'Nervous System Diseases-exhibit-Psychomotor Disorders', 'Oliguria-impair-Kidney Diseases', 'Fractures, Bone-mimic-Osteoporosis', 'Bone Diseases, Metabolic-considered-Osteoporotic Fractures', 'Acute Disease-impair-Drug Hypersensitivity', 'Parkinson Disease, Secondary-diagnosed-Tremor', 'Pain-noted-Headache Disorders, Secondary', 'Glioma-comprise-Astrocytoma', 'Heart Defects, Congenital-experience-Death', 'Radiculopathy-cause-Pain', 'Pain-cause-Retinal Degeneration', 'Pain-cause-Arthritis', 'Pain-cause-Synovitis', 'Neuritis-evidence-Gingival Overgrowth', 'Neuritis-evidence-Inflammation', 'Herpes Zoster-lessen-Neuralgia', 'Parkinson Disease-develop-Hallucinations', 'Aneurysm-prevent-Rupture', 'Death-prevent-Rupture', 'Respiratory Tract Diseases-show-Death', 'Jaundice-define-Jaundice, Neonatal', 'Gangrene-associated-Pain', 'Pain-associated-Gangrene', 'Dermatitis, Atopic-fall-Neurodermatitis', 'Aortic Aneurysm, Abdominal-differ-Arterial Occlusive Diseases', 'Arteriosclerosis-complicated-Gangrene', 'Arteriosclerosis-complicated-Ulcer', 'Gangrene-complicated-Infections', 'Ulcer-complicated-Infections', 'Emphysema-associated-Lung Diseases', 'Lung Diseases-associated-Emphysema', 'Emphysema-become-Dyspnea', "Melanoma-develop-Hutchinson's Melanotic Freckle", 'Emphysema-define-Airway Obstruction', 'MEG8-regulate-CIRBP', 'SERPINE1-determine-MIR34A', 'SERPINE1-determine-Carcinoma, Pancreatic Ductal', 'SIRT1-overexpressed-Prostatic Neoplasms', 'MIR34A-result-SIRT1', 'AKT3-identified-MIR22', 'HOTAIR-reduce-SETD2', 'HOTAIR-promote-SETD2', 'Carcinoma, Hepatocellular-promote-SETD2', 'HOTAIR-promote-Carcinoma, Hepatocellular', 'HOTAIR-downregulate-SETD2', 'Carcinoma, Hepatocellular-downregulate-SETD2', 'HOTAIR-downregulate-Carcinoma, Hepatocellular', 'CDKN2B-AS1-up-regulate-SIRT1', 'RGS4-caused-Lipopolysaccharides', 'AMBRA1-identified-MIR23A', 'CDKN2B-AS1-disrupt-SUZ12', 'CDKN2B-AS1-bind-SUZ12', 'MTOR-identify-MIR199A2', 'Diabetes Mellitus-increase-SIRT1', 'TENT4B-oligoadenylate-TERC', 'Osteosarcoma-target-SLBP', 'Osteosarcoma-up-regulate-SLBP', 'SIRT1-studied-Neoplasms', 'MIR21-associated-NOS2', 'NOS2-associated-MIR21', 'Neurodegenerative Diseases-exposed-HTT', 'Glucosamine-upregulate-NOX4', 'SIRT1-enhance-MIR34A', 'MIR9-3-result-SIRT1', 'MAPK1-identify-MIR378A', 'MAPK1-validate-MIR378A', 'BNIP3L-identify-MIR30A', 'MIR29C-compare-BDNF', 'Inflammation-promote-NFKBIA', 'SMAD7-use-Atherosclerosis', 'Atherosclerosis-decreased-SMAD7', 'PVT1-target-YAP1', 'CACNA1C-increase-Atrial Fibrillation', 'MIAT-form-AKT1', 'SIRT4-associated-MIR15B', 'MIR15B-associated-SIRT4', 'SIRT4-counteract-Mitochondrial Diseases', 'CCN2-upregulate-Carcinoma, Hepatocellular', 'MIR184-result-EZR', 'MIR375-identify-INS', 'EZR-identify-MIR184', 'Atorvastatin-decrease-SIRT1', 'SIRT1-up-regulate-Atorvastatin', 'Starch-relate-GPT', 'MIR19A-related-PRKAA1', 'Glucose-exposed-SIRT1', 'Diabetes Mellitus-exposed-SIRT1', 'Glucose-isolated-Diabetes Mellitus', 'Carcinoma, Hepatocellular-associated-SIRT6', 'SIRT6-associated-Carcinoma, Hepatocellular', 'Inflammation-downregulate-UBE2C', 'Hypertension-target-PARP1', 'MIR585-expressed-Hypertension', 'FGF2-precede-Myalgia', 'DANCR-regulate-PROX1', 'MIR185-reveal-POT1', 'AXL-rescue-Heart Arrest', 'CASP9-associate-MIR182', 'MIR182-associate-CASP9', 'BHLHE40-regulate-LINC00458', 'MIR127-identify-BCL6', 'CERK-result-Ceramides', 'BCL6-inhibit-Breast Neoplasms', 'Breast Neoplasms-associated-BCL6', 'BCL6-associated-Breast Neoplasms', 'Neoplasms-modulate-BCL6', 'MIR496-involved-MTOR', 'TERT-participate-Lung Diseases', 'TERC-participate-Lung Diseases', 'TERC-lead-ITGAM', 'Wounds and Injuries-reduce-SMAD4', 'SIRT2-knocked-Glioma', 'INS-combined-Glucose', 'Acarbose-spread-INS', 'Aortic Diseases-associated-Glucose', 'Glucose-associated-Aortic Diseases', 'Aortic Diseases-associated-Triglycerides', 'Triglycerides-associated-Aortic Diseases', 'Death-predict-Glucose', 'PIN1-reversed-Dithiothreitol', 'Glucose-reduce-GCG', 'Glucose-reduce-Diabetes Mellitus, Type 2', 'TXNIP-associated-Glucose', 'Glucose-associated-TXNIP', 'TXNIP-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-TXNIP', 'Pancreatic Diseases-compare-INS', 'Pancreatic Diseases-compare-Glucose', 'INS-predispose-Glucose', 'Pancreatic Diseases-predispose-Glucose', 'Glucose-include-Glucose Metabolism Disorders', 'Ginsenosides-inhibit-MAPT', 'Ginsenosides-prevent-MAPT', 'MAPT-alleviate-Neurodegenerative Diseases', 'Ginsenosides-inhibit-Tauopathies', 'Ginsenosides-alleviate-Neurodegenerative Diseases', 'INS-become-Glucose', 'INS-control-Glucose', 'INS-internalize-Glucose', 'INS-reduce-Fatty Acids', 'Glucose-reduce-Fatty Acids', 'RECQL4-investigate-Etoposide', 'INS-estimated-Glucose', 'INS-estimated-Octreotide', 'Glucose-increase-SIRT1', 'Glucose-induce-MAP3K5', 'MAP3K5-induced-Hyperglycemia', 'Glucose-induced-Hyperglycemia', 'MAP3K5-induced-Glucose', 'Glucose-assess-INS', 'HPSE-degrade-Heparitin Sulfate', 'INS-promote-Glucose', 'INS-evaluate-Diabetes Mellitus', 'Glucose-determine-Diabetes Mellitus, Type 2', 'INS-modulate-Glucose', 'INS-clamped-Diabetes Mellitus, Type 2', 'Glucose-clamped-Diabetes Mellitus, Type 2', 'Hypoglycemia-need-INS', 'Hypoglycemia-need-Glucose', 'Glycogen-cause-AGL', 'AGL-cause-Glycogen Storage Disease Type III', 'Glucose-contribute-INS', 'Hyperglycemia-contribute-INS', 'INS-arise-Hyperglycemia', 'Glucose-arise-Hyperglycemia', 'INS-measured-Hyperglycemia', 'Glucose-measured-Hyperglycemia', 'AR-determined-Prostatic Hyperplasia', 'Glucose-require-INS', 'INS-require-Diabetes Mellitus, Type 2', 'CERS1-prevent-Doxorubicin', 'Glucose-increase-BGLAP', 'Mannitol-increase-CAT', 'Idarubicin-result-FLT3', 'Idarubicin-result-Leukemia, Myeloid, Acute', 'Glucose-produce-INS', 'Glucose-present-CDKN2A', 'INS-require-Glucose', 'INS-assessed-Glucose', 'Cardenolides-affect-TTN', 'IL1B-ameliorated-Glucosamine', 'SLC2A1-proposed-Neoplasms', 'Glucose-proposed-Neoplasms', 'Glucose-reduce-Alzheimer Disease', 'Glucose-test-INS', 'Arthritis, Rheumatoid-shunt-Glucose', 'Coronary Artery Disease-include-CRP', 'Glucose-enhance-INS', 'INS-inhibit-Glucose', 'Glucose Intolerance-tend-INS', 'Glucose Intolerance-tend-Glucose', 'PPARG-coordinate-Glucose', 'PPARG-found-Alzheimer Disease', 'Glucose-found-Alzheimer Disease', 'Ouabain-investigate-INS', 'Drug-Related Side Effects and Adverse Reactions-investigate-INS', 'INS-evaluated-Glucose', 'Obesity-cause-INS', 'Obesity-cultured-Ouabain', 'Insulinoma-suspected-INS', 'Insulinoma-suspected-Glucose', 'Androgen-Insensitivity Syndrome-investigated-INS', 'Androgen-Insensitivity Syndrome-investigated-Glucose', 'SIRT1-increase-Phlorhizin', 'INS-performed-Glucose', 'Ascorbic Acid-inhibit-MAPK1', 'Doxorubicin-benefit-SIRT1', 'Breast Neoplasms-benefit-Doxorubicin', 'SIRT1-show-Doxorubicin', 'NAMPT-do-Glucose', 'NAMPT-delay-Glucose', 'NAMPT-use-Glucose', 'IGF1-associated-Fractures, Bone', 'Fractures, Bone-associated-IGF1', 'INS-studied-Glucose', 'Diabetes Mellitus-studied-INS', 'RETN-regulate-Glucose', 'ADIPOQ-correlated-Glucose', 'Diabetes Mellitus-associate-INS', 'INS-associate-Diabetes Mellitus', 'INS-maintain-Glucose', 'CDK9-complete-Daunorubicin', 'CDK9-complete-Leukemia, Myeloid, Acute', 'IKBKG-induce-Digitonin', 'INS-infused-Glucose', 'Doxorubicin-increase-TP53', 'Doxorubicin-interfere-NLRP3', 'Cardiovascular Diseases-induced-Doxorubicin', 'Glucose-funneled-INS', 'RRM2-induce-Glucose', 'Diabetes Mellitus-display-INS', 'UCP2-limit-Glucose', 'Inflammation-reduce-SLC2A1', 'Inflammation-reduce-Glucose', 'APOE-contain-Heparin', 'Extranodal Extension-contain-APOE', 'Extranodal Extension-contain-Heparin', 'MUC16-use-Icodextrin', 'Ghrelin-activate-Diglycerides', 'INS-normalize-Glucose', 'ALB-incubated-Glucose', 'NQO1-exhibit-Death', 'Glucose-assessed-INS', 'Fructosamine-detected-FN3K', 'INS-related-Glucose', 'Glucose-include-INS', 'Glucose-control-Diabetes Mellitus', 'N-Acetylneuraminic Acid-prevent-SIGLEC11', 'FMOD-lack-Keratan Sulfate', 'ELN-evaluated-Glycosaminoglycans', 'ELN-inhibit-Hyaluronic Acid', 'Glucose-assumed-INS', 'Glucose-suppress-INS', 'RGN-play-Ascorbic Acid', 'Sugars-reduce-ALPI', 'Glucose-measured-INS', 'Glucose-discussed-INS', 'INS-tend-Glucose', 'INS-improved-Glucose', 'INS-improved-Hyperglycemia', 'Polysaccharides-recruit-CD4', 'Glucose-occur-Diabetes Mellitus', 'Inositol Phosphates-implicated-IPMK', 'Glucosephosphate Dehydrogenase Deficiency-test-Phytic Acid', 'Glucuronides-determined-ABCG2', 'HPSE-lead-Heparitin Sulfate', 'Heparitin Sulfate-result-VEGFA', 'HPSE-degraded-Heparitin Sulfate', 'Plicamycin-abolish-SIRT1', 'LEP-reduced-Saponins', 'Glucose-associate-INS', 'INS-associate-Glucose', 'Hypertension-associate-INS', 'INS-associate-Hypertension', 'Glucose-produce-Hypertension', 'Glucose-associate-Hypertension', 'Hypertension-associate-Glucose', 'ANXA2-bind-Heparin', 'Glucose-abolish-ELN', 'INS-increase-Hypoglycemia', 'TP53-decrease-Glucose', 'TP53-increase-Neoplasms', 'Glucose-decrease-Neoplasms', 'TP53-inhibit-Pentosephosphates', 'ACHE-immunopurified-Sepharose', 'Congenital Hyperinsulinism-induced-Glucose', 'SIRT1-balanced-Glycosaminoglycans', 'Glucose-induced-SIRT1', 'ATXN2L-induced-Glucose', 'ATXN2L-prevented-Cholesterol', 'Glucose-prevented-Cholesterol', 'INS-regulate-Glucose', 'PRKAB1-play-Glucose', 'PRKAB1-play-Inflammation', 'Hyperinsulinism-maintain-Glucose', 'Starch-make-INS', 'Glycerol-decrease-TP53', 'Glucose-interpreted-IAPP', 'PRKAB1-follow-Glucose', 'ALB-associated-Heparin', 'Heparin-associated-ALB', 'Kidney Diseases-associated-Heparin', 'Heparin-associated-Kidney Diseases', 'INS-enhanced-Glucose', 'Alginates-improve-INS', 'INS-secrete-Glucose', 'Glutathione-verified-Maltose', 'CS-determined-Ascorbic Acid', 'Ascorbic Acid-restore-CS', 'SESN3-alter-Glucose', 'Glucose-detect-INS', 'Triglycerides-detect-INS', 'SDHB-mitigated-Ascorbic Acid', 'PTEN-dephosphorylate-Inositol', 'CST3-suggested-Digoxin', 'INS-stimulate-Glucose', 'INS-given-Glucose', 'CDKN2A-result-Glucose', 'SLC5A2-compare-Glucose', 'SLC5A2-delineate-Diabetes Mellitus, Type 2', 'SERPINA4-increase-Diabetes Mellitus', 'Metabolic Diseases-rely-Glycogen', 'SERPINA4-use-Streptozocin', 'SERPINA4-use-Diabetes Mellitus', 'INS-involved-Heart Diseases', 'Glucose-originate-Heart Diseases', 'Fatty Acids-originate-Heart Diseases', 'INS-involve-Glucose', 'ACE-cost-Digoxin', 'Death-cost-Digoxin', 'Ascorbic Acid-occur-SLC23A2', 'INS-used-Glucose', 'Octreotide-infused-INS', 'Octreotide-suppress-INS', 'Octreotide-used-Glucose', 'PRKCD-correlated-Glucose', 'PRKCD-correlated-Triglycerides', 'Obesity-correlated-Glucose', 'Obesity-correlated-Triglycerides', 'Etoposide-minimize-Drug-Related Side Effects and Adverse Reactions', 'CST3-correlate-Digoxin', 'Glucose-fail-INS', 'FNDC5-correlate-Glucose', 'Glucose-use-INS', 'GCG-suppress-Glucose', 'GCG-suppress-Diabetes Mellitus, Type 2', 'SIRT4-affect-Glucose', 'SIRT4-affect-Fatty Acids', 'Glucose-correlate-INS', 'INS-based-Glucose', 'Hyaluronic Acid-involved-CEMIP', 'APLN-increase-Glycosaminoglycans', 'Glycosaminoglycans-assessed-MAP1LC3A', 'FGF21-enhance-Glucose', 'INS-evaluate-Glucose', 'ADIPOQ-exhibit-Glucose', 'Inflammation-exhibit-Glucose', 'Glucose-increase-CRAT', 'INS-augment-Glucose', 'MDK-involved-Kidney Diseases', 'Heparin-involved-Kidney Diseases', 'ADIPOQ-exert-Glucose', 'INS-show-Glucose', 'Ascorbic Acid-associated-Metabolic Syndrome', 'Metabolic Syndrome-associated-Ascorbic Acid', 'SIRT1-achieved-Glucosamine', 'Glucose-increase-INS', 'Hypoglycemia-increase-INS', 'Glucose-remain-APOE', 'Inflammation-use-CRP', 'Ascorbic Acid-measured-Inflammation', 'Inflammation-measured-Ascorbic Acid', 'Fluorodeoxyglucose F18-measured-CAT', 'Fluorodeoxyglucose F18-measured-Glutathione', 'Puromycin-select-HPRT1', 'Infections-select-HPRT1', 'Sepharose-use-CFAP97', 'Infections-select-Puromycin', 'Octreotide-inhibit-INS', 'INS-prevent-Hypoglycemia', 'Octreotide-inhibit-Glucose', 'Glucose-prevent-Hypoglycemia', 'INS-decrease-Glucose', 'Octreotide-decrease-Glucose', 'rs45458701-transport-Nucleosides', 'INS-come-Glucose', 'Glucose-understand-Diabetes Mellitus', 'Pentosephosphates-linked-GSR', 'Sarcopenia-associated-APOB', 'APOB-associated-Sarcopenia', 'Sarcopenia-associated-Glucose', 'Glucose-associated-Sarcopenia', 'Sepharose-use-DNTT', 'ACHE-differ-N-Acetylneuraminic Acid', 'Mitochondrial Diseases-linked-INS', 'Glucose-underlie-INS', 'Fructose-decrease-GSTM1', 'Glucose-associated-LBP', 'LBP-associated-Glucose', 'LBP-associated-Glucose Intolerance', 'Glucose Intolerance-associated-LBP', 'Dinoprostone-associated-PTGER1', 'PTGER1-associated-Dinoprostone', 'Dinoprostone-associated-Inositol 1,4,5-Trisphosphate', 'Inositol 1,4,5-Trisphosphate-associated-Dinoprostone', 'ACHE-differ-Polysaccharides', 'Glucose-divided-INS', 'Hyaluronic Acid-injected-INS', 'Polysaccharides-determine-ACHE', 'INS-preferred-Fructosamine', 'Glucose-show-INS', 'INS-exhibit-Wounds and Injuries', 'Cardiomyopathies-differ-INS', 'Glucose-characterized-Wounds and Injuries', 'Glucose-exhibit-Wounds and Injuries', 'Glucose-reveal-INS', 'Glucose-reduce-INS', 'PPARGC1A-related-Glucose', 'Multiple Trauma-including-ALB', 'Multiple Trauma-found-ALB', 'Multiple Trauma-including-Ascorbic Acid', 'Multiple Trauma-found-Ascorbic Acid', 'Glucose-performed-INS', 'Sorbitol-generated-AKR1B1', 'Glucose-controlled-INS', 'CRP-include-Respiratory Distress Syndrome', 'Glucose-include-Respiratory Distress Syndrome', 'Heart Failure-achieve-INS', 'Glucose-result-MTOR', 'RRAD-induced-Etoposide', 'Lactose-digest-LCT', 'Glucose-exhibit-INS', 'TPI1-obtain-Glucose', 'Werner Syndrome-use-Glucose', 'INS-affect-Glucose', 'Pancreatic Diseases-develop-Glucose', 'INS-affect-Diabetes Mellitus', 'SERPINC1-modulate-Blood Coagulation Disorders', 'Heparin-modulate-Blood Coagulation Disorders', 'TTR-reveal-Hyaluronic Acid', 'PLCL1-come-Inositol 1,4,5-Trisphosphate', 'PLCL1-inhibit-Inositol 1,4,5-Trisphosphate', 'Butyric Acid-added-THPO', 'Butyric Acid-added-N-Acetylneuraminic Acid', 'Glucose-determine-INS', 'Ascorbic Acid-suppress-HIF1A', 'KL-influence-Glucose', 'Glucose-correlate-LEP', 'Triglycerides-correlate-LEP', 'ADIPOQ-predict-Glucose', 'CYBB-induced-Doxorubicin', 'G6PD-divert-Glucose', 'CYBB-result-Doxorubicin', 'CYBB-activated-Doxorubicin', 'CYBB-conferred-Doxorubicin', 'Glucose-lead-INS', 'Glucose-ensure-INS', 'Metabolic Diseases-ensure-INS', 'ADIPOQ-explained-Glucose', 'Coronary Artery Disease-explained-Glucose', 'Glucose-assessed-Congenital Hyperinsulinism', 'NFE2L2-magnified-Pentosephosphates', 'INS-accelerate-Glucose', 'Saponins-tested-NFE2L2', 'Glucose-demonstrate-INS', 'Glucose-demonstrate-Congenital Hyperinsulinism', 'INS-test-Glucose', 'INS-lead-Glucose', 'HAS2-stimulate-Hyaluronic Acid', 'Phospholipids-stimulate-HAS2', 'INS-required-Glucose', 'INS-achieved-Glucose', 'Glucose-increase-PRKAB1', 'Glucose-decrease-PRKAB1', 'Glucose-associated-PRKAB1', 'PRKAB1-associated-Glucose', 'GNE-required-N-Acetylneuraminic Acid', 'GNE-express-N-Acetylneuraminic Acid', 'GNE-associated-Polysaccharides', 'Polysaccharides-associated-GNE', 'Digoxin-administered-ACE', 'Glucose-associate-Hyperglycemia', 'Hyperglycemia-associate-Glucose', 'ELN-decrease-Glycosaminoglycans', 'Glucose-act-PRKAA2', 'Glucose-suggest-PARP1', 'Hyperinsulinism-indicate-INS', 'Prostaglandins-stimulated-KNG1', 'Prostaglandins-stimulated-Ascorbic Acid', 'INS-permit-Glucose', 'INS-permit-Chemical and Drug Induced Liver Injury', 'Hyperinsulinism-created-INS', 'Hyperinsulinism-created-Glucose', 'Sucrose-associated-MTOR', 'MTOR-associated-Sucrose', 'Sucrose-associated-Hyperkinesis', 'Hyperkinesis-associated-Sucrose', 'INS-lower-Glucose', 'INS-lower-Diabetes Mellitus, Type 2', 'Inflammation-affect-INS', 'Inflammation-affect-Glucose', 'COL1A1-upregulated-Glucose', 'Glucose-occur-INS', 'PTEN-regulated-Glucose', 'AQP3-use-Glycerol', 'DCXR-convert-Xylitol', 'Neuroblastoma-show-INS', 'Neuroblastoma-show-Glucose', 'TERT-increase-Glucose', 'TERT-involved-Glucose', 'GPT-increase-Cholesterol', 'Glucose-increase-Cholesterol', 'ABCB1-influence-Digitoxin', 'Glucose-cause-INS', 'Glucose-defined-INS', 'Diabetes Mellitus-defined-INS', 'Glucose-increase-FOXO1', 'MYSM1-enriched-Etoposide', 'MYSM1-associated-Melanoma', 'Melanoma-associated-MYSM1', 'Etoposide-associated-Melanoma', 'Melanoma-associated-Etoposide', 'Fluorodeoxyglucose F18-use-MAPT', 'Fluorodeoxyglucose F18-use-Glucose Metabolism Disorders', 'INS-prevent-Glucose', 'GH1-treated-Glucose', 'Octreotide-follow-Glucose', 'Hypertension-study-Octreotide', 'MMP1-evaluated-Ascorbic Acid', 'RETN-correlate-Glucose', 'Sepharose-followed-VIP', 'INS-mediated-Glucose', 'FPR1-respond-Infliximab', 'AQR-increased-Glucose', 'Cartilage Diseases-associated-ELN', 'ELN-associated-Cartilage Diseases', 'Cartilage Diseases-associated-Glycosaminoglycans', 'Glycosaminoglycans-associated-Cartilage Diseases', 'Glucose-determined-INS', 'CRP-retain-Diabetes Mellitus', 'Glucose-retain-Diabetes Mellitus', 'INS-shift-Glucose', 'INS-monitor-Blood Glucose', 'GDF11-restore-Sugars', 'Glucose-calculated-INS', 'LYZ-incubated-Ribose', 'Diabetes Mellitus-include-Glucose', 'Glucose-associated-PTH', 'PTH-associated-Glucose', 'PTH-completed-Glucose', 'TTR-enhance-Dithiothreitol', 'APOE-show-Glucose', 'Fluorodeoxyglucose F18-lack-SLC6A3', 'Alzheimer Disease-lack-SLC6A3', 'Inflammation-prevent-SIGLEC11', 'Ascorbic Acid-turn-MAPK1', 'N-Acetylneuraminic Acid-prevent-Inflammation', 'MAPK1-analysed-Ascorbic Acid', 'Glucose-exposed-NOS3', 'Glucose-decrease-NOS3', 'Glucose-accelerate-NOS3', 'GAR1-determined-Galactose', 'Glucose-improve-SLC2A4', 'SLC2A4-reduce-Glucose', 'FGF21-decline-Glucose', 'Glucose-promote-INS', 'INS-investigate-Glucose', 'Hypertension-investigate-Glucose', 'Hypertension-use-Glucose', 'IGF1-characterize-Glucose', 'Saponins-inhibit-AKT1', 'BDNF-mediate-Glucose', 'Ceramides-influence-INS', 'Infections-withdrawn-MTOR', 'Infections-withdrawn-Mycophenolic Acid', 'ALB-increase-Cholesterol', 'Ceramides-regulate-INS', 'CYP2D6-metabolize-Venlafaxine Hydrochloride', 'Cholesterol-disrupt-ABCA1', 'MTOR-up-regulate-Cholesterol', 'VDR-associated-Liver Cirrhosis', 'Liver Cirrhosis-associated-VDR', 'rs1544410-associated-Liver Cirrhosis', 'Liver Cirrhosis-associated-rs1544410', 'Lipoxins-inhibit-MPO', 'Inflammation-inhibit-MPO', 'Lipoxins-suppress-Inflammation', 'ELOVL2-associated-Eicosapentaenoic Acid', 'Eicosapentaenoic Acid-associated-ELOVL2', 'NLRP3-activate-Palmitic Acid', 'NLRP3-activate-Lipopolysaccharides', 'Ceramides-increased-NFKB1', 'FGF23-reduce-Calcitriol', 'G(M1) Ganglioside-associated-INS', 'INS-associated-G(M1) Ganglioside', 'G(M1) Ganglioside-contribute-INS', 'Cholecalciferol-lower-PTH', 'MVK-known-Inflammation', 'MVK-play-Inflammation', 'Cholesterol-known-Inflammation', 'Cholesterol-play-Inflammation', 'Palmitic Acid-protect-NFE2L2', 'Drug-Related Side Effects and Adverse Reactions-protect-NFE2L2', 'Drug-Related Side Effects and Adverse Reactions-induced-Palmitic Acid', 'ABCA1-measure-Cholesterol', 'CRP-correlate-Death', 'PON1-assessed-Cholesterol', 'LMNA-treat-Phosphatidylinositols', 'PON1-prevent-Lipid Peroxides', 'Calcitriol-show-ALPP', 'APOD-shown-Eicosanoids', 'APOD-act-Eicosanoids', 'CDKN2A-associated-Cholesterol', 'Cholesterol-associated-CDKN2A', 'CDKN2A-associated-Proteinuria', 'Proteinuria-associated-CDKN2A', 'INS-lower-Cholesterol', 'ACE-use-Cardiovascular Diseases', 'Obesity-lower-Cholesterol', 'CETP-involved-Cholesterol', 'INS-associated-Fatty Acids', 'Fatty Acids-associated-INS', 'Fatty Acids-decrease-INS', 'Cholesterol-lowering-CRP', 'CREBBP-abolished-Sodium Dodecyl Sulfate', 'UCP3-catalyse-Fatty Acids', 'PNPLA6-characterized-Phospholipids', 'PNPLA6-regulate-Phospholipids', 'ALB-suffer-Dementia', 'Cholesterol-suffer-Dementia', 'INS-reduce-Fatty Acids, Nonesterified', 'ACE-decrease-Cholesterol', 'INS-increase-Diabetes Mellitus, Type 2', 'INS-fail-Diabetes Mellitus, Type 2', 'INS-improve-Diabetes Mellitus, Type 2', 'Diabetes Mellitus, Type 2-reduce-Fatty Acids, Nonesterified', 'Cholesterol-use-APOE', 'Neoplasms-use-APOE', 'Hypocalcemia-shown-PTH', 'Hypocalcemia-regulate-PTH', 'Hypocalcemia-compare-Cholecalciferol', 'SERPINA7-correlated-Hypothyroidism', 'Hypothyroidism-correlated-Cholesterol', 'Diabetes Mellitus, Type 2-suggest-INS', 'Diabetes Mellitus, Type 2-suggest-Fatty Acids, Nonesterified', 'SIRT1-suggest-Cockayne Syndrome', 'ADIPOQ-correlated-Cholesterol', 'Lipofuscin-activate-RARA', 'Sphingolipids-map-MAPT', 'Alzheimer Disease-implicated-MAPT', 'Sphingolipids-implicated-Alzheimer Disease', 'Triglycerides-include-INS', 'Polycystic Ovary Syndrome-associated-Triglycerides', 'Triglycerides-associated-Polycystic Ovary Syndrome', 'PON1-hydrolyze-Phospholipids', 'Blood Platelet Disorders-stimulate-KNG1', 'Epoprostenol-reduce-Blood Platelet Disorders', 'Calcitriol-incubated-SLC20A2', 'Calcitriol-maintain-SLC20A2', 'Cholesterol-inhibit-HMGCR', 'Fatty Acids-involve-INS', 'BDNF-increase-Fatty Acids, Omega-3', 'TSPO-involved-Cholesterol', 'APOE-regulate-Cholesterol', 'APOE-flipped-Alzheimer Disease', 'Cholesterol-flipped-Alzheimer Disease', 'TRPV1-activated-Capsaicin', 'PIGA-involved-Glycosylphosphatidylinositols', 'CERT1-followed-Ceramides', 'CERT1-increase-Death', 'Death-replicate-Ceramides', 'APOE-transport-Cholesterol', 'INS-remain-Triglycerides', 'APOB-observed-Triglycerides', 'Cholesterol-reduce-FOXN1', 'Cholesterol-metabolized-CYP11A1', 'Cholesterol-remain-CRP', 'RETN-enhance-Fatty Acids', 'RETN-alter-Dysgeusia', 'Dysgeusia-enhance-Fatty Acids', 'PLA2G1B-increase-Phospholipids', 'TTR-correlated-Triglycerides', 'Dinoprostone-lower-PAX5', 'VIP-precontracted-15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid', 'Dinoprostone-lead-PAX5', 'Cholesterol-assessed-CRP', 'CETP-increase-Cholesterol', 'TP53-detected-Pigmentation Disorders', 'Triglycerides-associated-PLIN2', 'PLIN2-associated-Triglycerides', 'CFH-switch-Cholesterol', 'rs10801555-switch-Cholesterol', 'Cholesterol-impact-Neurodegenerative Diseases', 'Dementia-observed-APOB', 'Dementia-observed-Cholesterol', 'Arachidonic Acid-induced-VWF', 'Blood Platelet Disorders-induced-Arachidonic Acid', 'Capsaicin-upregulate-SIRT1', 'SIRT1-upregulate-Heart Arrest', 'Capsaicin-upregulate-Heart Arrest', 'Atorvastatin-treated-ALPP', 'Atorvastatin-treated-Osteosarcoma', 'Cholesterol-observed-CRP', 'DBP-measured-Calcitriol', 'DBP-calculated-Calcitriol', 'MLXIPL-linked-Triglycerides', 'ODC1-increase-Lipid Peroxides', 'STAR-associated-Cholesterol', 'Cholesterol-associated-STAR', 'Dinoprostone-bear-TLR4', 'Lipopolysaccharides-bear-TLR4', 'Lipopolysaccharides-challenged-Dinoprostone', 'DNER-raise-Cholesterol', 'Fatty Acids-involved-PARP1', 'MFSD2A-described-Docosahexaenoic Acids', 'Aortic Aneurysm, Abdominal-inhibit-Dinoprostone', 'PLD2-produce-Phosphatidic Acids', 'Calcitriol-related-VDR', 'STARD3-involved-Cholesterol', 'STARD3-involved-Neurodegenerative Diseases', 'INS-include-Fatty Acids, Nonesterified', 'IL10-associated-Triglycerides', 'Triglycerides-associated-IL10', 'Plant Oils-increase-Autoimmune Diseases', 'LEP-control-Fatty Acids, Nonesterified', 'Cholesterol-improve-INS', 'SIRT4-regulate-Fatty Acids', 'NLRP3-increase-Cholesterol', 'Hypothyroidism-activate-NLRP3', 'Hypothyroidism-increase-Cholesterol', 'CERS1-required-Ceramides', 'Fatty Acids-mediated-UCP1', 'Dinoprostone-increase-IGFBP5', 'APOE-support-Nerve Degeneration', 'Cholesterol-support-Nerve Degeneration', 'VIT-coupled-Palmitic Acid', 'APOE-include-Cholesterol', 'SIRT1-function-Cholesterol', 'Ceramides-impair-INS', 'Dinoprostone-control-IGFBP5', 'IGFBP5-contribute-Inflammation', 'Dinoprostone-contribute-Inflammation', 'PNPLA8-possess-Fatty Acids, Unsaturated', 'SIRT3-play-Fatty Acids, Nonesterified', 'TRPV1-appear-Capsaicin', 'CRYL1-associated-Cholesterol', 'Cholesterol-associated-CRYL1', 'CRYL1-associated-Alzheimer Disease', 'Alzheimer Disease-associated-CRYL1', 'Alzheimer Disease-involve-Cholesterol', 'rs662799-associated-Triglycerides', 'Triglycerides-associated-rs662799', 'rs662799-associated-Dyslipidemias', 'Dyslipidemias-associated-rs662799', 'Eicosapentaenoic Acid-increase-ELN', 'Fatty Acids, Unsaturated-involve-INS', 'PYY-affected-Fatty Acids', 'Dinoprostone-result-Osteoporosis', 'TRPV1-reduced-Capsaicin', 'TRPV1-reduced-Rhinitis', 'Rhinitis-reduced-Capsaicin', 'Docosahexaenoic Acids-fed-THY1', 'Docosahexaenoic Acids-overexpress-THY1', 'Synucleinopathies-overexpress-THY1', 'Sodium Dodecyl Sulfate-identified-Cataract', 'SIRT1-increase-Fatty Acids', 'GH1-reflected-Cholesterol', 'Cholecalciferol-reduce-KL', 'KL-measured-Cholecalciferol', 'GH1-lower-Cholesterol', 'Alzheimer Disease-prompt-INS', 'Alzheimer Disease-prompt-Fatty Acids, Omega-3', 'Alzheimer Disease-improve-Fatty Acids, Omega-3', 'Cholesterol-increased-INS', 'Hepatitis C-correlate-INS', 'Hepatitis C-correlate-Triglycerides', 'BDNF-correlate-Cholesterol', 'Fatty Acids-increase-LEP', 'FGF23-inhibit-Calcitriol', 'PTGDR2-found-Prostaglandin D2', 'Atorvastatin-coadminister-CYP3A4', 'Diabetes Mellitus-predicted-CRP', 'CD4-found-Cholesterol', 'Obesity-exposed-INS', 'Obesity-exposed-Fatty Acids', 'CERS1-implicate-Ceramides', 'Cholesterol-decrease-CRP', 'LEP-reduce-Cholesterol', 'RHOA-enriched-Linoleic Acid', 'Adenomatous Polyposis Coli-enriched-RHOA', 'APOB-track-Cholesterol', 'Palmitic Acid-increase-RUNX2', 'Osteosarcoma-increase-RUNX2', 'CD8A-activate-Dinoprostone', 'Valproic Acid-affect-HDAC9', 'SOST-play-Calcitriol', 'SIRT1-correlate-Triglycerides', 'Metabolic Syndrome-calculated-INS', 'SIRT1-associated-Cholesterol', 'Cholesterol-associated-SIRT1', 'FGF23-suppress-Calcitriol', 'FGF23-induce-Hypophosphatemia, Familial', 'Hypophosphatemia, Familial-suppress-Calcitriol', 'NPC1L1-play-Cholesterol', 'CHRNA3-associated-Cholesterol', 'Cholesterol-associated-CHRNA3', 'CHRNA3-associated-Coronary Artery Disease', 'Coronary Artery Disease-associated-CHRNA3', 'Sphingolipids-affected-APOE', 'Cholesterol-decrease-GGH', 'GGH-increase-Triglycerides', 'Inflammation-associated-Cholesterol', 'Cholesterol-associated-Inflammation', 'Eicosanoids-exert-PPARG', 'Eicosapentaenoic Acid-show-SIRT1', 'INS-enhance-Fatty Acids, Essential', 'Leukotriene B4-initiated-ALOX5', 'UCP2-maintain-Fatty Acids', 'UCP2-shift-Fatty Acids', 'GBA-involved-Ceramides', 'GBA-result-Pneumonia, Lipid', 'Ceramides-result-Pneumonia, Lipid', 'CERS5-enriched-Palmitic Acid', 'Fluvastatin-increase-SIRT6', 'UCP3-regulate-Fatty Acids', 'Triglycerides-reveal-Pulmonary Disease, Chronic Obstructive', 'Ceramides-inhibit-RAC1', 'Phosphatidic Acids-heighten-MTOR', 'Phosphatidic Acids-converge-MTOR', 'Prostaglandins-observed-KNG1', 'GH1-show-Triglycerides', 'KL-inhibit-Calcitriol', 'INS-assess-Fatty Acids, Nonesterified', 'BGLAP-determined-Triglycerides', 'INS-assess-Insulin Resistance', 'Insulin Resistance-assess-Fatty Acids, Nonesterified', 'SLPI-behave-Sodium Dodecyl Sulfate', 'Capsaicin-counteract-SIRT6', 'Capsaicin-counteract-Osteosarcoma', 'GH1-predict-Cholesterol', 'PPARA-involved-Fatty Acids', 'PPARA-involved-Glucose Metabolism Disorders', 'Death-cause-CRP', 'Death-linked-Cholesterol', 'Calcitriol-synthesize-BGLAP', 'C1QTNF9-prevent-Palmitic Acid', 'INS-decrease-Cholesterol', 'IGFBP4-employ-Osteosarcoma', 'Osteosarcoma-demonstrate-Calcitriol', 'GH1-result-Cholesterol', 'Calcitriol-use-CYP27B1', 'DHCR7-decrease-Cholesterol', 'SERPINA1-derived-Sodium Dodecyl Sulfate', 'PPARA-affect-Fatty Acids', 'GRN-rescue-Lipofuscin', 'INS-become-Hypertension', 'Cholesterol-become-Hypertension', 'Atorvastatin-associated-SHBG', 'SHBG-associated-Atorvastatin', 'Atorvastatin-reduce-SHBG', 'APOD-bind-Endocannabinoids', 'Ceramides-stabilize-BACE1', 'Triglycerides-indicate-INS', 'Calcifediol-bind-VDR', 'INS-shown-Coronary Artery Disease', 'Triglycerides-shown-Coronary Artery Disease', 'VDR-bind-Cardiovascular Diseases', 'Carotid Artery Diseases-related-INS', 'Valproic Acid-counteract-CLU', 'Glycosylphosphatidylinositols-added-BACE1', 'IGF1R-track-Breast Neoplasms', 'Ceramides-modulate-PPA1', 'Cholesterol-involved-SCARB1', 'SCARB1-affect-Cholesterol', 'Neuroblastoma-increase-DHCR24', 'Cholesterol-induce-Neuroblastoma', 'DHCR24-viewed-Cholesterol', 'Triglycerides-fast-ADIPOQ', 'Cholesterol-bind-MAP2', 'Cholesterol-synthesized-MAP2', 'DMPK-associated-Triglycerides', 'Triglycerides-associated-DMPK', 'Eicosanoids-inhibit-NOS2', 'GH1-reduce-Fatty Acids', 'Cholecalciferol-inhibit-Prostatic Hyperplasia', 'Atorvastatin-upregulate-CD4', 'Melanoma-upregulated-SLC27A2', 'Melanoma-upregulated-Fatty Acids', 'PCSK9-influence-Cholesterol', 'APOA1-correlate-Alzheimer Disease', 'gamma-Linolenic Acid-fail-PTH', 'GC-associated-Cholecalciferol', 'Cholecalciferol-associated-GC', 'Blood Platelet Disorders-increase-Epoprostenol', 'Phospholipids-determine-INS', 'Triglycerides-down-regulate-LEP', 'CLU-related-Cholesterol', 'Triglycerides-depend-INS', 'Atherosclerosis-modify-APOA1', 'Atherosclerosis-modify-Cholesterol', 'Lipofuscin-stimulate-GAST', 'HGF-inhibited-Dinoprostone', 'HTRA1-show-Lipofuscin', 'HTRA1-show-Death', 'HGF-induce-Carcinoma, Hepatocellular', 'Cyclosporine-associated-ABCB1', 'ABCB1-associated-Cyclosporine', 'BACE1-stimulated-Cyclosporine', 'BACE1-stimulated-Neuroblastoma', 'Cyclosporine-report-Leukemia, Myeloid, Acute', 'Ghrelin-involved-GH1', 'Ghrelin-stimulate-GH1', 'Ghrelin-do-GGH', 'MTR-increase-Glutathione', 'Enalapril-cause-REN', 'Octreotide-act-SST', 'Enalaprilat-include-ACE', 'BCL2-targeted-Dactinomycin', 'NFE2L2-increase-Glutathione', 'Lisinopril-resemble-ACE', 'ACE-considered-Myocardial Infarction', 'Lisinopril-considered-Myocardial Infarction', 'MAPT-ameliorate-Inflammation', 'Glutathione-ameliorate-Inflammation', 'Dipeptides-cleaved-CNDP1', 'GHRH-enhance-Ghrelin', 'Enalapril-include-ACE', 'Dactinomycin-fail-BACE1', 'Dactinomycin-abolish-BACE1', 'Glutathione-measured-CAT', 'PPIB-bind-Cyclosporine', 'FOXO3-result-Bleomycin', 'Insulin Glargine-evaluate-INS', 'INS-evaluate-Myoclonus', 'INS-used-Insulin Glargine', 'ACE-associated-Lisinopril', 'Lisinopril-associated-ACE', 'TKT-determine-Glutathione', 'PPARG-reduce-Glutathione', 'MME-compare-Heart Failure, Systolic', 'Enalapril-compare-Heart Failure, Systolic', 'INS-indicated-Diabetes Mellitus', 'Insulin Lispro-indicated-Diabetes Mellitus', 'Glutathione-consist-GSR', 'Ghrelin-induced-INS', 'Ghrelin-correlate-INS', 'Glutathione-linked-TRPM2', 'Ghrelin-show-INS', 'Ghrelin-show-Obesity', 'OXT-vasopressin-Oxytocin', 'ELN-increase-Glutathione', 'Hypothalamic Neoplasms-produce-Oxytocin', 'Aspartame-reduce-SIRT1', 'Glutathione-interact-CERS2', 'Neurodegenerative Diseases-play-Glutathione', 'Glutathione-follow-GSR', 'Glutathione-increase-GSR', 'Hypertension-follow-GSR', 'Hypertension-increase-GSR', 'Ghrelin-induce-MAPK1', 'GCLC-participate-Glutathione', 'Neurotoxicity Syndromes-participate-Glutathione', 'Glutathione-reduce-Neurotoxicity Syndromes', 'RB1-restore-Glutathione', 'VAV3-associated-Thyrotropin', 'Thyrotropin-associated-VAV3', 'rs12126655-associated-Thyrotropin', 'Thyrotropin-associated-rs12126655', 'INS-compare-Insulin Glargine', 'CAT-do-Glutathione Disulfide', 'ALB-associated-Parathyroid Hormone', 'Parathyroid Hormone-associated-ALB', 'KL-exposed-Bleomycin', 'FGF23-upregulated-Bleomycin', 'KL-assessed-Idiopathic Pulmonary Fibrosis', 'Idiopathic Pulmonary Fibrosis-exposed-Bleomycin', 'FGF23-upregulated-Idiopathic Pulmonary Fibrosis', 'CLOCK-show-Ghrelin', 'Enalapril-reduced-Hypertension', 'N-Formylmethionine Leucyl-Phenylalanine-induce-FPR1', 'Insulin Glargine-include-INS', 'POMC-inhibit-Oxytocin', 'Cyclosporine-cause-CDKN1A', 'Cyclosporine-cause-CDKN2A', 'GH1-attenuate-Lymphopenia', 'Ghrelin-attenuate-Lymphopenia', 'GLRX-catalyze-Glutathione', 'Enalapril-increase-REN', 'INS-show-Atazanavir Sulfate', 'GSTM2-related-Glutathione', 'TXN-work-Glutathione', 'Cyclosporine-suppress-IFNA1', 'Enalapril-inhibit-ACE', 'Cyclosporine-suppress-Hepatitis C', 'ACE-lowering-Hypertension', 'Enalapril-lowering-Hypertension', 'GSR-involved-Glutathione', 'Cyclosporine-increase-CST3', 'Hypertrophy, Left Ventricular-use-Enalapril', 'Octreotide-decrease-GH1', 'Octreotide-restrain-GH1', 'Thyrotropin-decreased-TRH', 'UPF1-exhibit-Alzheimer Disease', 'Glutathione-exhibit-Alzheimer Disease', 'Anorexia-contribute-CCK', 'Anorexia-contribute-Ghrelin', 'Parkinson Disease-correlated-CAT', 'Parkinson Disease-correlated-Glutathione', 'Infections-associated-LEP', 'LEP-associated-Infections', 'Infections-associated-Ghrelin', 'Ghrelin-associated-Infections', 'CD4-include-Cyclosporine', 'Enalapril-studied-Hypertension', 'Glutathione-associated-SMPD1', 'SMPD1-associated-Glutathione', 'TPP1-cleave-Oligopeptides', 'Osteoporosis-include-TNFSF11', 'AKT1-regulated-Glutathione', 'Osteoporosis-include-Teriparatide', 'Oxytocin-related-OXTR', 'GLS-observed-Glutathione', 'Inflammation-involve-USP18', 'ELN-increase-Infliximab', 'VEGFA-approved-Anophthalmos', 'Ranibizumab-approved-Anophthalmos', 'VEGFA-approved-Neoplasms', 'Bevacizumab-approved-Neoplasms', 'Infliximab-mediated-RYR2', 'Rituximab-combine-DDIT3', 'Neoplasms-combine-DDIT3', 'Rituximab-achieve-DDIT3', 'Rituximab-sensitize-Neoplasms', 'Rituximab-achieve-Lymphoma', 'Infliximab-prevented-TRPV4', 'Infliximab-elicited-KNG1', 'Infliximab-induced-KNG1', 'KNG1-monitored-Infliximab', 'MCOLN1-known-Infliximab', 'FGF9-decrease-Infliximab', 'RGN-exert-Infliximab', 'RGN-regulate-Infliximab', 'RGN-induced-Infliximab', 'Infliximab-increased-RGN', 'Infliximab-examine-Alzheimer Disease', 'Rituximab-remain-F8', 'Thrombocytopenia-remain-F8', 'Thrombocytopenia-diagnosed-Rituximab', 'SIRT6-overcome-Trastuzumab', 'SIRT6-overcome-Breast Neoplasms', 'Infliximab-cause-KL', 'Renal Insufficiency, Chronic-disrupt-Infliximab', 'Infliximab-bind-TRPC1', 'Infliximab-induced-PTGDS', 'Infliximab-result-CTSD', 'CTSD-trigger-Death', 'Infliximab-trigger-Death', 'Infliximab-stimulate-CTSD', 'CTSD-activated-Infliximab', 'RGN-serve-Infliximab', 'RGN-involved-Cataract', 'Bevacizumab-act-VEGFA', 'Tuberculosis-associated-Rituximab', 'Rituximab-associated-Tuberculosis', 'CERS2-induce-Infliximab', 'CREB1-referred-Pain', 'Infliximab-regulate-PTH', 'PTH-use-Infliximab', 'Infliximab-account-PTH', 'CISD2-play-Infliximab', 'CACNA1A-encode-Infliximab', 'VEGFA-improve-Carcinoma, Non-Small-Cell Lung', 'Bevacizumab-improve-Carcinoma, Non-Small-Cell Lung', 'CCL2-induce-Infliximab', 'Infliximab-decrease-CRP', 'Panitumumab-target-EGFR', 'TTR-driven-Infliximab', 'PSEN1-promote-Infliximab', 'Alzheimer Disease-promote-Infliximab', 'Denosumab-directed-TNFSF11', 'VEGFA-use-Infliximab', 'TRPV2-abolish-Infliximab', 'TRPV2-abolish-Muscle Hypotonia', 'TRPV2-cause-Muscle Hypotonia', 'Infliximab-cause-Muscle Hypotonia', 'RGN-discuss-Infliximab', 'Trastuzumab-associated-ERBB2', 'ERBB2-associated-Trastuzumab', 'Trastuzumab-associated-Breast Neoplasms', 'Breast Neoplasms-associated-Trastuzumab', 'ERBB2-benefit-Trastuzumab', 'Trastuzumab-benefit-Neoplasms', 'Trastuzumab-indicated-ERBB2', 'Trastuzumab-indicated-Breast Neoplasms', 'TNFSF11-inhibit-Denosumab', 'TNFSF11-prevent-Osteoporosis', 'Denosumab-prevent-Osteoporosis', 'Lipopolysaccharides-lead-NOX4', 'Lipopolysaccharides-induced-SIGLEC11', 'Lipopolysaccharides-increase-VEGFA', 'IRAK1-undergo-Lipopolysaccharides', 'NOTCH1-associated-Lipopolysaccharides', 'Lipopolysaccharides-associated-NOTCH1', 'NLRP3-block-Lipopolysaccharides', 'Lipopolysaccharides-activate-NOS2', 'Lipopolysaccharides-induce-CD86', 'TNF-regulated-Lipopolysaccharides', 'TWF1-increase-Lipopolysaccharides', 'PPM1D-elevated-Lipopolysaccharides', 'Sepsis-induced-Lipopolysaccharides', 'PRKAB1-disrupted-Lipopolysaccharides', 'Lipopolysaccharides-correlated-AKT1', 'Lipopolysaccharides-pre-treated-SYK', 'Lipopolysaccharides-induced-TLR2', 'Parkinson Disease-induced-TLR2', 'Lipopolysaccharides-induced-Parkinson Disease', 'rs60682848-bear-LMNA', 'GRN-associated-Sclerosis', 'Sclerosis-associated-GRN', 'rs5848-associated-Sclerosis', 'Sclerosis-associated-rs5848', 'rs1776180-considered-EXO1', 'rs1801195-associated-Breast Neoplasms', 'Breast Neoplasms-associated-rs1801195', 'EXO1-lead-rs1776180', 'FOXO3-relate-rs13217795', 'FOXO3-truncate-rs13217795', 'rs13217795-associated-FOXO3', 'FOXO3-associated-rs13217795', 'rs104893877-carry-Brain Stem Neoplasms', 'rs1990622-associated-TARDBP', 'TARDBP-associated-rs1990622', 'LRP1-associated-Alzheimer Disease', 'Alzheimer Disease-associated-LRP1', 'rs1799986-associated-Alzheimer Disease', 'Alzheimer Disease-associated-rs1799986', 'rs1815739-result-ACTN3', 'MLKL-expressed-rs763812068', 'IL6-identified-Death', 'CPB2-decrease-Death', 'Death-decrease-rs2146881', 'CISD2-express-Breast Neoplasms', 'SPON1-associated-rs11606345', 'rs11606345-associated-SPON1', 'rs10801555-link-Inflammation', 'Spinal Stenosis-emerge-SQSTM1', 'HSF2-associate-Death', 'Death-associate-HSF2', 'rs1416733-associate-Death', 'Death-associate-rs1416733', 'BANF1-identify-Genetic Diseases, Inborn', 'rs387906871-identify-Genetic Diseases, Inborn', 'BANF1-impair-rs387906871', 'BCHE-produced-rs1126680', 'FOXO4-mediate-Melanoma', 'rs113488022-result-FOXO4', 'WRN-evaluate-Prostatic Neoplasms', 'rs1801195-evaluate-Prostatic Neoplasms', 'CRP-found-rs1205', 'GBA-investigate-Parkinson Disease', 'rs421016-investigate-Parkinson Disease', 'WRN-identified-Neoplasms', 'rs748089844-identified-Neoplasms', 'Progeria-caused-rs58596362', 'rs10748842-suggest-NRG3', 'NRG3-associate-rs10748842', 'rs10748842-associate-NRG3', 'rs10748842-examine-NRG3', 'Kidney Diseases-prevent-FXYD1', 'Leukoencephalopathies-predict-NOTCH3', 'Leukoencephalopathies-predict-rs201118034', 'rs2866943-cause-PTPRT', 'rs63750264-act-PSEN1', 'rs63750264-compare-PSEN1', 'rs10801555-associated-Glycogen Storage Disease Type II', 'Glycogen Storage Disease Type II-associated-rs10801555', 'CFH-contribute-Glycogen Storage Disease Type II', 'Progeria-based-LMNA', 'PSEN1-followed-Alzheimer Disease', 'rs63749824-followed-Alzheimer Disease', 'PSEN1-develop-Alzheimer Disease', 'rs63749824-develop-Alzheimer Disease', 'PLCG2-associated-Alzheimer Disease', 'Alzheimer Disease-associated-PLCG2', 'PTGER2-participate-Amyotrophic Lateral Sclerosis', 'TLR4-affected-Boutonneuse Fever', 'rs4986790-affected-Boutonneuse Fever', 'TLR4-affected-Myocardial Infarction', 'rs4986790-affected-Myocardial Infarction', 'Fractures, Bone-reveal-TNFRSF11B', 'Fractures, Bone-reveal-rs3134070', 'LRRK2-reported-Parkinson Disease', 'rs34637584-reported-Parkinson Disease', 'SULT1A1-result-rs9282861', 'CFH-associated-Hyperpigmentation', 'Hyperpigmentation-associated-CFH', 'rs10801555-associated-Hyperpigmentation', 'Hyperpigmentation-associated-rs10801555', 'Alzheimer Disease-detect-LRP1', 'Alzheimer Disease-detect-rs1799986', 'rs36196656-decrease-GFRA2', 'CFH-genotype-Inflammation', 'rs1061170-genotype-Inflammation', 'rs9315202-predict-KL', 'rs9315202-result-KL', 'MRPL38-lead-rs34136221', 'rs2054576-associated-Hyperuricemia', 'Hyperuricemia-associated-rs2054576', 'rs11555236-reported-SIRT3', 'HSD11B1-associated-Alzheimer Disease', 'Alzheimer Disease-associated-HSD11B1', 'KDM1A-predispose-rs7548692', 'MYD88-show-Neoplasms', 'rs387907272-show-Neoplasms', 'MYD88-associated-Neoplasms', 'Neoplasms-associated-MYD88', 'rs387907272-associated-Neoplasms', 'Neoplasms-associated-rs387907272', 'rs75527207-include-CFTR', 'APOE-become-rs6902875', 'LRRK2-observe-rs34637584', 'Kidney Failure, Chronic-bear-IL6', 'Kidney Failure, Chronic-bear-rs180795', 'LMNA-reveal-rs730882262', 'rs2075650-tag-APOE', 'rs2603462-colocalize-ELOVL4', 'DNM3-vary-rs2421947', 'rs113488022-associated-TERT', 'TERT-associated-rs113488022', 'TCL1A-mark-rs2887399', 'CETP-associated-Alzheimer Disease', 'Alzheimer Disease-associated-CETP', 'SUCNR1-identify-rs13079080', 'CALR-play-Inflammation', 'IL6-observed-rs2069827', 'COL15A1-associated-rs4142986', 'rs4142986-associated-COL15A1', 'COL15A1-associated-Atherosclerosis', 'Atherosclerosis-associated-COL15A1', 'Atherosclerosis-associated-rs4142986', 'rs4142986-associated-Atherosclerosis', 'LRRK2-found-Parkinson Disease', 'rs34410987-found-Parkinson Disease', 'rs58596362-produce-LMNA', 'KL-associated-Prostatic Neoplasms', 'Prostatic Neoplasms-associated-KL', 'ADA-selected-rs73598374', 'ADA-associated-rs73598374', 'rs73598374-associated-ADA', 'rs80356717-disrupt-RRM1', 'ACTN3-affect-Seizures', 'rs1815739-affect-Seizures', 'VKORC1-increase-Osteoporosis', 'rs9923231-increase-Osteoporosis', 'rs79907212-alter-LMNA', 'HRG-affected-rs9898', 'Aortic Aneurysm, Abdominal-evaluated-MTHFR', 'rs9898-affected-Death', 'Aortic Aneurysm, Abdominal-evaluated-rs1801133', 'ABCC1-appear-Lung Neoplasms', 'AGER-associated-Glycogen Storage Disease Type II', 'Glycogen Storage Disease Type II-associated-AGER', 'rs1800625-associated-Glycogen Storage Disease Type II', 'Glycogen Storage Disease Type II-associated-rs1800625', 'rs1041981-associate-Stroke', 'Stroke-associate-rs1041981', 'DSG1-find-rs2199301', 'rs59267781-induce-LMNA', 'rs1262893315-take-INS', 'rs10524523-associated-Alzheimer Disease', 'Alzheimer Disease-associated-rs10524523', 'PYCR1-reveal-rs758601634', 'LMNA-include-Cardiomyopathies', 'Muscular Dystrophy, Emery-Dreifuss-caused-LMNA', 'Muscular Dystrophy, Emery-Dreifuss-caused-rs267607613', 'ESR1-contain-rs1709183', 'rs956572-associated-BCL2', 'BCL2-associated-rs956572', 'IFNG-associated-Tuberculosis', 'Tuberculosis-associated-IFNG', 'rs2430561-associated-Tuberculosis', 'Tuberculosis-associated-rs2430561', 'BNC2-demonstrate-rs62543565', 'rs978739-situated-TAS2R16', 'GDF5-show-Osteoarthritis, Hip', 'Progeria-found-LMNA', 'Progeria-found-rs58596362', 'rs405509-related-Alzheimer Disease', 'TRHR-associated-Sarcopenia', 'Sarcopenia-associated-TRHR', 'TMEM106B-implicated-Neurodegenerative Diseases', 'Neurodegenerative Diseases-implicated-rs3173615', 'rs3824968-associated-Alzheimer Disease', 'Alzheimer Disease-associated-rs3824968', 'Dementia-associated-rs6265', 'rs6265-associated-Dementia', 'rs8192678-influence-Parkinson Disease', 'rs2802292-correlate-FOXO3', 'rs2071403-associated-TPO', 'TPO-associated-rs2071403', 'APOB-associated-Vascular Calcification', 'Vascular Calcification-associated-APOB', 'rs5742904-associated-Vascular Calcification', 'Vascular Calcification-associated-rs5742904', 'CAV1-play-Sarcopenia', 'PON1-test-rs662', 'rs6994992-examine-NRG1', 'rs662-evaluate-Alzheimer Disease', 'MPO-involved-Alzheimer Disease', 'MPO-associated-Alzheimer Disease', 'Alzheimer Disease-associated-MPO', 'rs2333227-associated-Alzheimer Disease', 'Alzheimer Disease-associated-rs2333227', 'MAPT-involved-Nerve Degeneration', 'FGB-interact-Stroke', 'rs1800790-interact-Stroke', 'Intellectual Disability-carry-CNP', 'Intellectual Disability-carry-rs2070106', 'EGFR-predominate-rs121434568', 'rs4845625-associated-Atrial Fibrillation', 'Atrial Fibrillation-associated-rs4845625', 'PITX2-associated-rs4611994', 'rs4611994-associated-PITX2', 'Atrial Fibrillation-associated-rs4611994', 'rs4611994-associated-Atrial Fibrillation', 'rs1800947-associated-Myocardial Infarction', 'Myocardial Infarction-associated-rs1800947', 'ESR1-enhanced-Obesity', 'VEGFA-increased-rs833069', 'OXTR-show-rs53576', 'rs1045642-correlated-ABCB1', 'CDC42-increase-Death', 'rs76349024-disrupt-GDF9', 'rs9621532-influence-TIMP3', 'rs9625132-measure-TIMP3', 'Chorioretinitis-associated-CFH', 'CFH-associated-Chorioretinitis', 'Chorioretinitis-associated-rs1061170', 'rs1061170-associated-Chorioretinitis', 'APOE-associated-Memory Disorders', 'Memory Disorders-associated-APOE', 'rs1801133-associated-Memory Disorders', 'Memory Disorders-associated-rs1801133', 'FURIN-influence-Infections', 'rs4702-influence-Infections', 'SDC4-associated-Coronary Artery Disease', 'Coronary Artery Disease-associated-SDC4', 'rs1981429-associated-Coronary Artery Disease', 'Coronary Artery Disease-associated-rs1981429', 'AKT1-evaluate-rs3803304', 'RPA3-develop-Osteoarthritis', 'rs11769597-develop-Osteoarthritis', 'FOXO3-develop-Osteoarthritis', 'rs4946936-develop-Osteoarthritis', 'rs63751438-include-MAPT', 'GJA4-associated-Coronary Artery Disease', 'Coronary Artery Disease-associated-GJA4', 'rs1764391-associated-Coronary Artery Disease', 'Coronary Artery Disease-associated-rs1764391', 'ADIPOQ-detected-rs185847354', 'GJA4-show-Myocardial Infarction', 'rs1764391-show-Myocardial Infarction', 'FAM13A-associated-Carcinoma, Squamous Cell', 'Carcinoma, Squamous Cell-associated-FAM13A', 'rs9224-associated-Carcinoma, Squamous Cell', 'Carcinoma, Squamous Cell-associated-rs9224', 'MST1-regulated-rs3197999', 'MST1-regulated-Inflammatory Bowel Diseases', 'MAPT-lost-rs63751273', 'rs63751273-confer-MAPT', 'IFNG-impacted-Inflammation', 'Inflammation-impacted-rs2430561', 'rs550942-associated-CNTF', 'CNTF-associated-rs550942', 'rs1046896-associated-FN3KRP', 'FN3KRP-associated-rs1046896', 'Diverticulosis, Colonic-associated-WNT4', 'WNT4-associated-Diverticulosis, Colonic', 'Diverticulosis, Colonic-associated-rs22538787', 'rs22538787-associated-Diverticulosis, Colonic', 'ACTN3-compare-rs1815739', 'HERPUD1-associate-Choroiditis', 'Choroiditis-associate-HERPUD1', 'HERPUD1-expressed-Choroiditis', 'rs2217332-associate-Choroiditis', 'Choroiditis-associate-rs2217332', 'rs405509-decrease-Alzheimer Disease', 'GSTP1-serve-Neutropenia', 'rs1695-serve-Neutropenia', 'rs704180-associated-Sclerosis', 'Sclerosis-associated-rs704180', 'ADAMTS14-associated-Osteoarthritis', 'Osteoarthritis-associated-ADAMTS14', 'rs4747096-associated-Osteoarthritis', 'Osteoarthritis-associated-rs4747096', 'S100A1-observe-rs2300403', 'Cardiomyopathy, Dilated-induced-LMNA', 'Cardiomyopathy, Dilated-induced-rs56984562', 'ADAMTS5-increase-Osteoarthritis', 'rs226794-increase-Osteoarthritis', 'FUS-linked-Amyotrophic Lateral Sclerosis', 'MTHFR-encode-rs1801133', 'rs5744256-associated-IL18', 'IL18-associated-rs5744256', 'rs800292-cause-CFH', 'MYD88-diagnosed-Waldenstrom Macroglobulinemia', 'rs387907272-diagnosed-Waldenstrom Macroglobulinemia', 'SOD1-encode-Amyotrophic Lateral Sclerosis', 'rs12409277-affect-PRDM16', 'IL6-associated-Hearing Loss, Central', 'Hearing Loss, Central-associated-IL6', 'KL-associated-Cerebral Infarction', 'Cerebral Infarction-associated-KL', 'rs1800796-associated-Hearing Loss, Central', 'Hearing Loss, Central-associated-rs1800796', 'rs3754032-associated-WDR77', 'WDR77-associated-rs3754032', 'rs3754032-observed-WDR77', 'SLC19A1-investigated-Alzheimer Disease', 'rs1051266-investigated-Alzheimer Disease', 'rs5918-demonstrate-ITGB3', 'rs5918-demonstrate-Coronary Artery Disease', 'rs914246-regulate-FTCD', 'PEAR1-identified-Blood Platelet Disorders', 'rs12041331-identified-Blood Platelet Disorders', 'rs2687201-associated-Carcinoma, Hepatocellular', 'Carcinoma, Hepatocellular-associated-rs2687201', 'rs2687201-determined-FOXP1', 'TREM2-lead-Alzheimer Disease', 'rs75932628-lead-Alzheimer Disease', 'KL-linked-Kidney Failure, Chronic', 'rs577912-linked-Kidney Failure, Chronic', 'HOXB13-associated-Prostatic Neoplasms', 'Prostatic Neoplasms-associated-HOXB13', 'Erectile Dysfunction-play-rs1799983', 'FTO-associated-Obesity', 'Obesity-associated-FTO', 'Coronary Artery Disease-associated-IL6R', 'IL6R-associated-Coronary Artery Disease', 'Coronary Artery Disease-associated-rs7529229', 'rs7529229-associated-Coronary Artery Disease', 'Obesity-associated-GH1', 'GH1-associated-Obesity', 'TP53-regulate-Neoplasms', 'TP53-study-Carcinoma, Pancreatic Ductal', 'CHI3L1-observed-Fibrosis', 'CHI3L1-promote-Fibrosis', 'Osteoarthritis-increased-MAP3K5', 'IGF2-increase-Stomach Neoplasms', 'Infections-enhance-MBL2', 'IGF2-used-Stomach Neoplasms', 'Death-enhance-RHEB', 'HTT-regarded-Huntington Disease', 'RHEB-regulated-Tuberous Sclerosis', 'APOE-develop-Alzheimer Disease', 'Immunologic Deficiency Syndromes-associated-INS', 'INS-associated-Immunologic Deficiency Syndromes', 'UNC5B-hinder-Aneurysm', 'Alzheimer Disease-assess-APOE', 'Alzheimer Disease-include-APOE', 'IL6-measured-Aneurysm', 'INS-highlight-Brain Injury, Chronic', 'AKT1-act-Neoplasms', 'MAPT-show-Tauopathies', 'PKD2-reach-Kidney Diseases', 'Chemical and Drug Induced Liver Injury-increase-ALB', 'BMI1-associate-Alzheimer Disease', 'Alzheimer Disease-associate-BMI1', 'ACE-found-Ovarian Neoplasms', 'RPS6KB1-upregulated-Alzheimer Disease', 'Neurodegenerative Diseases-take-MAPT', 'Weight Loss-gain-SHBG', 'RARRES2-enhance-Carcinoma, Squamous Cell', 'MAPT-used-Neurodegenerative Diseases', 'MAPT-follow-Neurodegenerative Diseases', 'RARRES2-downregulated-Carcinoma, Squamous Cell', 'TF-missed-Alzheimer Disease', 'Kearns-Sayre Syndrome-diminish-LOX', 'Alzheimer Disease-show-TF', 'KL-play-Neoplasms', 'WRN-silence-Neoplasms', 'IL6-used-Parkinson Disease', 'ACHE-predict-Atrophy', 'Sleep Wake Disorders-arise-PER2', 'Muscular Atrophy-suggest-INS', 'INS-contribute-Death', 'FOXO3-assess-Death', 'FOXO3-associated-Stomach Neoplasms', 'Stomach Neoplasms-associated-FOXO3', 'PTH-avoid-Bone Diseases, Metabolic', 'VWF-increase-Diabetes Mellitus', 'Diabetes Mellitus-result-VWF', 'VWF-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-VWF', 'VWF-diagnosed-Diabetes Mellitus', 'PTH-induce-Hypercalcemia', 'VWF-involved-Diabetes Mellitus', 'Neoplasms-adapt-MTOR', 'Neoplasms-become-MTOR', 'IL2-induced-Drug Hypersensitivity', 'Kidney Failure, Chronic-fail-COL4A3', 'EGFR-investigate-Sarcopenia', 'GDF11-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-GDF11', 'Diabetes Mellitus, Type 1-take-INS', 'FOXO3-play-Intervertebral Disc Degeneration', 'FOXO3-aggravate-Mitochondrial Diseases', 'FOXO3-decrease-Retinal Degeneration', 'ADIPOQ-collected-Cardiovascular Diseases', 'PAX6-remain-Cataract', 'PAX6-observed-Cataract', 'RETN-shown-Autoimmune Diseases', 'RETN-play-Autoimmune Diseases', 'Cataract-express-PAX6', 'Diabetes Mellitus-show-ALB', 'Diabetes Mellitus-start-INS', 'Neuroblastoma-transfected-MAPT', 'MAPT-compare-Alzheimer Disease', 'Diabetes Mellitus-initiate-INS', 'EFEMP1-play-Alzheimer Disease', 'ALB-associated-Femoral Neoplasms', 'Femoral Neoplasms-associated-ALB', 'KL-mitigate-Pulmonary Disease, Chronic Obstructive', 'LEP-predict-Malnutrition', 'AQP4-detected-Alzheimer Disease', 'Werner Syndrome-designated-WRN', 'AMH-predict-Ovarian Diseases', 'Coronary Artery Disease-adjusted-CRP', 'IGFBP1-associated-Metabolic Syndrome', 'Metabolic Syndrome-associated-IGFBP1', 'FNDC5-provide-Hip Fractures', 'SOD1-accumulate-Liver Neoplasms', 'Hypertension-associated-SERPINE1', 'SERPINE1-associated-Hypertension', 'Hypertension-remain-INS', 'FST-elevated-Diabetes Mellitus', 'INS-include-Glucose Metabolism Disorders', 'WRN-abrogated-Neoplasms', 'INS-promote-Alzheimer Disease', 'Sarcopenia-base-CST3', 'ERCC6-cause-Cockayne Syndrome', 'ANXA2-increased-Infections', 'ANXA2-treat-Infections', 'Diabetes Mellitus-related-VEGFA', 'PON1-related-Coronary Artery Disease', 'PON1-modulate-Coronary Artery Disease', 'AGER-show-Macular Degeneration', 'PRELP-inhibit-Choroidal Neovascularization', 'KITLG-determine-Alzheimer Disease', 'KITLG-described-Alzheimer Disease', 'IGFBP3-rescue-Heart Arrest', 'KITLG-delay-Alzheimer Disease', 'FOXP1-suppress-Carcinoma, Hepatocellular', 'FOXP1-affect-Carcinoma, Hepatocellular', 'NNMT-measured-Parkinson Disease', 'NNMT-implicated-Parkinson Disease', 'NNMT-affected-Parkinson Disease', 'PSEN2-identified-Alzheimer Disease', 'MTHFR-associated-Dementia', 'Dementia-associated-MTHFR', 'MTHFR-investigate-Myelodysplastic Syndromes', 'MTHFR-extracted-Myelodysplastic Syndromes', 'Myelodysplastic Syndromes-correlate-MTHFR', 'Pulmonary Fibrosis-carry-NHP2', 'COL15A1-impact-Atherosclerosis', 'COL15A1-induced-Atherosclerosis', 'NHP2-reported-Dyskeratosis Congenita', 'Hyperinsulinism-followed-INS', 'COL15A1-localize-Atherosclerosis', 'Neoplasms-reflect-IL6', 'BGLAP-protect-Diabetes Mellitus', 'SIRT1-involved-Inflammation', 'EREG-predominate-Arteritis', 'SOD1-amplify-Neurotoxicity Syndromes', 'Amyotrophic Lateral Sclerosis-express-SOD1', 'MTHFR-occur-Memory Disorders', 'PRKAA1-contribute-Neurodegenerative Diseases', 'Seizures-modulate-GH1', 'Hypertension-compromised-ACE', 'Prostatic Neoplasms-stratified-KLK3', 'Alzheimer Disease-associated-EPHA1', 'EPHA1-associated-Alzheimer Disease', 'WRN-target-Neoplasms', 'HCRT-focus-Sleep Wake Disorders', 'HCRT-include-Obesity', 'BDNF-expressed-Alzheimer Disease', 'MGP-implicated-Bone Neoplasms', 'MGP-associated-Tooth Loss', 'Tooth Loss-associated-MGP', 'Death-mediated-TNF', 'FGF23-associate-Infections', 'Infections-associate-FGF23', 'APOE-proposed-Alzheimer Disease', 'Chronic Traumatic Encephalopathy-characterized-MAPT', 'Cockayne Syndrome-carry-ERCC6', 'BIN1-involved-Alzheimer Disease', 'Alzheimer Disease-show-ALB', 'Hypertrophy-display-IGF1R', 'Muscle Rigidity-result-LMNB1', 'WRN-confer-Cardiovascular Diseases', 'PRKAA2-assess-Osteoarthritis', 'Alzheimer Disease-derived-MAPT', 'PCSK9-treat-Cardiovascular Diseases', 'Postoperative Cognitive Complications-associated-CRP', 'CRP-associated-Postoperative Cognitive Complications', 'MECP2-confer-Prostatic Neoplasms', 'Hyperparathyroidism-caused-PTH', 'Alzheimer Disease-increased-APOD', 'TP53-seen-Cataract', 'Infections-increase-NEDD8', 'DNMT1-result-Heart Arrest', 'SHBG-used-Diabetes Mellitus', 'SERPINA4-aggravate-Inflammation', 'Malaria, Cerebral-reduce-VNN1', 'Coronary Artery Disease-show-ACE', 'APOE-confer-Death', 'GAP43-differ-Atrial Fibrillation', 'GAP43-maintain-Atrial Fibrillation', 'CA3-represent-Sarcopenia', 'CLU-correlated-Hypercholesterolemia', 'Stroke-recognize-COL17A1', 'COL17A1-tend-Diabetes Mellitus, Type 2', 'MAPT-elevated-Alzheimer Disease', 'LYZ-found-Dry Eye Syndromes', 'GFAP-suffer-Alzheimer Disease', 'GFAP-investigated-Alzheimer Disease', 'Chronic Disease-associated-IL6', 'IL6-associated-Chronic Disease', 'HSF1-decrease-Cardiotoxicity', 'Diabetes Mellitus-base-ALLC', 'HUWE1-provide-Leukemia', 'Neoplasms-linked-BNIP3', 'Sepsis-altered-ANXA5', 'CEACAM3-identified-Colorectal Neoplasms', 'CEACAM3-associated-Neoplasms', 'Neoplasms-associated-CEACAM3', 'Hypogonadism-selected-LEP', 'MSTN-identify-Sarcopenia', 'MAPT-prompt-Neurotoxicity Syndromes', 'MAPT-confer-Neurodegenerative Diseases', 'MAPT-aggregate-Neurodegenerative Diseases', 'PTH-rose-Osteoporosis', 'Alzheimer Disease-show-CD8A', 'CYP19A1-demonstrate-Drug-Related Side Effects and Adverse Reactions', 'GDF9-linked-Ovarian Diseases', 'SYP-suffer-Metabolic Syndrome', 'INS-preferred-Hypoglycemia', 'CENPU-upregulated-Breast Neoplasms', 'CENPU-play-Breast Neoplasms', 'ALDH2-associated-Airway Obstruction', 'Airway Obstruction-associated-ALDH2', 'PRL-evaluated-Endocrine System Diseases', 'HAPLN1-promote-Melanoma', 'VDR-increase-Death, Sudden', 'APOL1-recognized-Renal Insufficiency, Chronic', 'APOL1-encode-Renal Insufficiency, Chronic', 'Alzheimer Disease-exert-PTGS2', 'Infections-include-NXF1', 'Infections-associated-NXF1', 'NXF1-associated-Infections', 'Diabetes Mellitus-modify-ABCC9', 'ADIPOQ-regard-Cardiovascular Diseases', 'BTK-display-Mastocytosis, Systemic', 'Sleep Initiation and Maintenance Disorders-combined-APOE', 'TP53-display-Neoplasms', 'TP53-escape-Neoplasms', 'POU5F1-help-Neoplasms', 'FASLG-overexpressed-Neoplasms', 'Neoplasms-overexpressed-FASLG', 'Hypothalamic Neoplasms-lead-AVP', 'SYNM-associate-Alzheimer Disease', 'Alzheimer Disease-associate-SYNM', 'SYNM-cross-linked-Death', 'PNPLA6-found-Neuroblastoma', 'SOST-regulate-Osteoporosis', 'Inflammation-increase-NOS2', 'KCNQ4-associated-Prostatic Neoplasms', 'Prostatic Neoplasms-associated-KCNQ4', 'Hypertension-started-ACE', 'Death-inject-INS', 'Rothmund-Thomson Syndrome-show-RECQL4', 'SOD2-nitrated-Carcinoma, Pancreatic Ductal', 'TDP-43 Proteinopathies-show-TMEM106B', 'SIRT2-inhibit-Cardiomegaly', 'SIRT2-reduce-Diabetic Cardiomyopathies', 'SIRT2-involved-Skin Diseases', 'Aneuploidy-propose-FOXM1', 'TNFRSF11B-increase-Diabetes Mellitus', 'FOXM1-prevent-Aneuploidy', 'WRN-result-Chromosome Aberrations', 'FGF20-associated-Parkinson Disease', 'Parkinson Disease-associated-FGF20', 'ESR1-related-Ovarian Diseases', 'ESR1-include-Ovarian Diseases', 'HMOX1-target-Osteoporosis', 'MAPT-detected-Alzheimer Disease', 'BACE1-prepared-Neuroblastoma', 'MYH9-caused-Genetic Diseases, Inborn', 'EREG-found-Neoplasms', 'SIRT1-reduced-Pulmonary Disease, Chronic Obstructive', 'EGFR-correlated-Pulmonary Disease, Chronic Obstructive', 'DHCR24-identified-Alzheimer Disease', 'LEP-associated-Prostatic Intraepithelial Neoplasia', 'Prostatic Intraepithelial Neoplasia-associated-LEP', 'Hypothalamic Diseases-reduce-GGH', 'CD4-respond-Adrenal Insufficiency', 'Neuroblastoma-stressed-TYR', 'Neoplasms-suppress-CYP19A1', 'Diabetes Mellitus, Type 1-offer-INS', 'TNF-associate-Fractures, Bone', 'Fractures, Bone-associate-TNF', 'ADIPOQ-modulate-Metabolic Diseases', 'ADIPOQ-compare-Sarcopenia', 'SIRT1-predict-Carcinoma, Hepatocellular', 'SLC6A3-remain-Alzheimer Disease', 'MAPK14-precipitate-Death', 'Diabetes Mellitus-present-TAT', 'Leukocytosis-increase-CRP', 'STAT3-decrease-Multiple Myeloma', 'IL6-affect-Multiple Myeloma', 'Multiple Myeloma-improve-STAT3', 'KL-linked-Death', 'OTX2-emphasize-Retinal Degeneration', 'ALB-influence-Death', 'Spherocytosis, Hereditary-identified-PRDX2', 'PRDX2-associated-Spherocytosis, Hereditary', 'Spherocytosis, Hereditary-associated-PRDX2', 'MYOC-localized-Glaucoma', 'MYOC-occur-Glaucoma', 'APOE-correlated-Alzheimer Disease', 'RPS14-identified-Myelodysplastic Syndromes', 'CHAT-surround-Plaque, Amyloid', 'CLOCK-remain-Parkinson Disease', 'CLOCK-affect-Parkinson Disease', 'SLC5A2-reduce-Diabetes Mellitus', 'PLS1-associated-Hearing Loss', 'Hearing Loss-associated-PLS1', 'FOXO1-compare-Osteoarthritis', 'FOXO1-regulate-Osteoarthritis', 'FOXO1-play-Osteoarthritis', 'EIF4E-related-Stomach Neoplasms', 'TMEM37-reported-Neoplasms', 'TTR-affect-Amyloid Neuropathies, Familial', 'Amyloid Neuropathies, Familial-caused-TTR', 'TMEM37-lost-Neoplasms', 'CNR2-increase-Inflammation', 'Inflammation-regulated-CNR2', 'NSD1-cause-Sotos Syndrome', 'Corneal Diseases-synthesise-ELN', 'P4HA1-promote-Neoplasms', 'P4HA1-associated-Breast Neoplasms', 'Breast Neoplasms-associated-P4HA1', 'P4HA1-associated-Glioma', 'Glioma-associated-P4HA1', 'PTEN-inhibit-Disorders of Sex Development', 'TRIB3-play-Fibrosis', 'TRIB3-affect-Sarcopenia', 'ATM-correlate-Status Epilepticus', 'ALB-evaluated-Femoral Neck Fractures', 'Glucose Metabolism Disorders-induce-MAP3K5', 'Infections-express-MAP3K5', 'Atherosclerosis-affect-RETN', 'TP53-affected-Coronary Artery Disease', 'TP53-suggest-Coronary Artery Disease', 'CFTR-exhibit-Neoplasms', 'LCN2-predict-Acute Kidney Injury', 'Hyperkalemia-suppress-REN', 'CASP8-enhanced-Lupus Erythematosus, Systemic', 'CERS2-known-Neoplasms', 'Renal Insufficiency-altered-ALB', 'APOE-protect-Neurodegenerative Diseases', 'Aneuploidy-related-AURKA', 'ABCA1-decreased-Diabetes Mellitus', 'TP53-affect-Heart Arrest', 'Sleep Wake Disorders-impair-MAPT', 'CRP-show-Pulmonary Disease, Chronic Obstructive', 'CD4-identify-HIV Infections', 'FSTL3-increase-Heart Failure', 'Alzheimer Disease-reveal-PPARG', 'KISS1-described-Neoplasms', 'INS-slow-Hypotension', 'FOXA1-validated-Breast Neoplasms', 'ELN-enhanced-Hyperhomocysteinemia', 'TYR-result-Melanoma', 'Diabetes Mellitus, Type 2-implicated-INS', 'Atherosclerosis-improve-SIRT1', 'AGER-play-Fatty Liver', 'REN-remain-Death', 'LEP-provide-Inflammation', 'Death-associated-AFP', 'AFP-associated-Death', 'Bone Resorption-inhibit-CTSK', 'Alzheimer Disease-known-APOE', 'LEP-altered-Obesity', 'IL6ST-induce-Hypertrophy', 'Cataract-performed-FN3K', 'SIRT7-play-Cardiomyopathies', 'Bone Neoplasms-caused-IGF1', 'TRPV1-include-Osteoarthritis', 'APOE-associated-Neurodegenerative Diseases', 'Neurodegenerative Diseases-associated-APOE', 'KL-reduced-Kidney Failure, Chronic', 'Diabetes Mellitus-diagnosed-INS', 'SIRT6-upregulated-Carcinoma, Squamous Cell', 'AMH-produced-Ovarian Neoplasms', 'AHR-become-Neoplasms', 'IGF1-exist-Muscular Diseases', 'Prostatic Neoplasms-receive-AR', 'AR-associated-Fractures, Bone', 'Fractures, Bone-associated-AR', 'SIRT2-make-Drug-Related Side Effects and Adverse Reactions', 'HPSE-play-Hyperplasia', 'Prostatic Neoplasms-involve-AR', 'Sleep Apnea, Obstructive-show-SIRT1', 'Fibrosis-alleviated-GGH', 'KDR-documented-Alzheimer Disease', 'VWF-fail-Hemorrhage', 'Neoplasms-target-SIRT1', 'SIRT1-serve-Neoplasms', 'CRP-respond-Bacterial Infections', 'CDKN2A-result-Neoplasms', 'Myalgia-hypothesise-INS', 'TACR1-prevent-Venous Thrombosis', 'ACE2-utilize-Infections', 'TRH-suffer-Acute Disease', 'LIN28A-implicated-Glucose Metabolism Disorders', 'PABPN1-lead-Muscular Dystrophies', 'Colitis, Ulcerative-express-SIRT1', 'CFH-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-CFH', 'TP53-lead-Heart Arrest', 'CFH-play-Inflammation', 'Neoplasms-stimulate-ATM', 'RPTOR-associated-Hypertension', 'Hypertension-associated-RPTOR', 'MAPT-associated-Extranodal Extension', 'Extranodal Extension-associated-MAPT', 'RPTOR-enhance-Obesity', 'Leukemia-related-KIR2DL4', 'GPM6A-related-Neurodegenerative Diseases', 'PNPLA6-find-Organophosphate Poisoning', 'SLC17A5-explain-Neoplasms', 'Alzheimer Disease-associated-CHI3L1', 'CHI3L1-associated-Alzheimer Disease', 'CHI3L1-reveal-Alzheimer Disease', 'CHI3L1-suggest-Alzheimer Disease', 'CHI3L1-increase-Alzheimer Disease', 'DUSP22-downregulated-Skin Neoplasms', 'ESR1-associated-Macular Degeneration', 'Macular Degeneration-associated-ESR1', 'REN-described-Hypertension', 'SIRT1-affect-Atherosclerosis', 'AGER-associate-Fibrosis', 'Fibrosis-associate-AGER', 'FGF21-alleviate-Metabolic Diseases', 'PKD2-estimated-Polycystic Kidney Diseases', 'ALB-decrease-Cardiac Output, Low', 'INS-counter-Diabetes Mellitus', 'FLNA-accumulate-Osteoporosis', 'MAPT-accumulate-Alzheimer Disease', 'Infections-result-CD8A', 'CD8A-decreased-Infections', 'Kidney Failure, Chronic-linked-CFAP97', 'INS-affected-Obesity', 'IL13-contribute-Graves Disease', 'ELN-assess-Fibrosis', 'Diabetes Mellitus, Type 1-fulfil-INS', 'Prostatic Neoplasms-abrogated-RB1', 'AHSG-affect-Sarcopenia', 'ACE2-associated-Peripheral Arterial Disease', 'Peripheral Arterial Disease-associated-ACE2', 'Alzheimer Disease-exclude-APOE', 'ERCC8-confer-Drug Hypersensitivity', 'SIRT1-protect-Atrophy', 'INS-predispose-Diabetes Mellitus, Type 2', 'LMNA-model-Progeria', 'Infections-enhanced-TAX1BP1', 'TAX1BP1-restrain-Infections', 'NPPA-predict-Death', 'HMGB1-released-Fractures, Bone', 'HMGB1-lead-Wounds and Injuries', 'TNFRSF11B-related-Sexual Dysfunction, Physiological', 'KLK3-indicate-Prostatitis', 'KLK3-suffer-Prostatic Neoplasms', 'KLK3-reveal-Prostatic Neoplasms', 'SIRT6-delay-Nerve Degeneration', 'MME-increased-Alzheimer Disease', 'Muscle Weakness-regulated-LMNA', 'BAK1-regulate-Nerve Degeneration', 'Nervous System Diseases-produce-PNPLA6', 'Weight Gain-associated-CRP', 'CRP-associated-Weight Gain', 'Neuroblastoma-used-PNPLA6', 'Glucose Intolerance-accompanied-INS', 'Glucose Intolerance-increase-INS', 'KL-resemble-Multiple Organ Failure', 'KL-suggested-Chronic Kidney Disease-Mineral and Bone Disorder', 'LMNA-increased-Alzheimer Disease', 'Colorectal Neoplasms-examined-LGR5', 'LMNA-affected-Alzheimer Disease', 'LMNA-up-regulated-Alzheimer Disease', 'LGR5-treated-Neoplasms', 'LGR5-influence-Colorectal Neoplasms', 'PDGFRB-linked-Communicable Diseases', 'PRL-produce-Neoplasms', 'CRH-act-Neuroendocrine Tumors', 'APOE-develop-Dementia', 'Progeria-show-NOS3', 'RRAD-associate-Diabetes Mellitus', 'Diabetes Mellitus-associate-RRAD', 'PINK1-result-Parkinson Disease', 'FTO-decreased-Osteoporosis', 'Osteoporosis-demethylate-RUNX2', 'PPARG-play-Inflammation', 'CYP2D6-metabolised-Liver Diseases', 'TNF-mediated-Inflammation', 'TP53-affect-Neoplasms', 'SIRT6-reduced-Neuroblastoma', 'MTOR-delay-Ovarian Diseases', 'BMP2-linked-Osteoporosis', 'LMNA-associated-Musculoskeletal Diseases', 'Musculoskeletal Diseases-associated-LMNA', 'Osteoarthritis-linked-SIRT1', 'NFE2L2-correspond-Mitochondrial Diseases', 'NFE2L2-impact-Tooth, Impacted', 'GSR-decrease-Cataract', 'Cataract-upregulated-GJA1', 'Anemia, Iron-Deficiency-classified-TF', 'MEIS1-use-Communicable Diseases', 'MEIS1-regulate-Communicable Diseases', 'NGFR-associated-Osteosarcoma', 'Osteosarcoma-associated-NGFR', 'MEIS1-expressed-Kidney Diseases', 'STC1-enhance-Thyroid Neoplasms', 'MEIS1-play-Leukemia', 'SELENOP-lead-Nervous System Diseases', 'KL-influence-Neoplasms', 'Precursor Cell Lymphoblastic Leukemia-Lymphoma-express-WNT16', 'MADCAM1-ameliorate-Encephalomyelitis, Autoimmune, Experimental', 'CD9-associated-Inflammation', 'Inflammation-associated-CD9', 'Hypothyroidism-detected-TRH', 'Hypothyroidism-screened-TRH', 'Arthritis, Rheumatoid-start-TNF', 'AR-associated-Prostatic Neoplasms', 'Prostatic Neoplasms-associated-AR', 'STAT1-decreased-Infections', 'CST3-followed-Death', 'DOT1L-silence-Heart Arrest', 'Fatty Liver-appear-PDP1', 'PGK1-identified-Supranuclear Palsy, Progressive', 'UCP1-investigate-Diabetes Mellitus', 'UCP1-affect-Diabetes Mellitus', 'SERPINF1-treat-Retinal Diseases', 'UCP1-affect-Glucose Metabolism Disorders', 'Hyperoxia-stimulate-ACE2', 'ALB-used-Cardiovascular Diseases', 'Hypoxia-reduced-UTRN', 'NAGLU-reported-Hypertension', 'Hypertension-start-NAGLU', 'NAGLU-start-Hypertension', 'INS-increase-Neoplasms', 'CD7-regarded-Lymphoma, T-Cell, Cutaneous', 'CRH-enhance-Sleep Wake Disorders', 'VEGFA-considered-Glycogen Storage Disease Type II', 'Alzheimer Disease-increase-NEFL', 'NEFL-show-Alzheimer Disease', 'NEFL-show-Dementia', 'CD4-define-Inflammation', 'Neoplasms-use-G6PD', 'WRN-contribute-Williams Syndrome', 'SLC25A24-lead-Brain Diseases, Metabolic', 'MAPT-know-Tauopathies', 'Sleep Initiation and Maintenance Disorders-fall-HCRT', 'MAPT-improve-Tauopathies', 'Osteoarthritis-modify-IL1RN', 'Burkitt Lymphoma-foster-TCF3', 'Burkitt Lymphoma-produce-CCND3', 'TCF3-activate-Burkitt Lymphoma', 'Renal Insufficiency, Chronic-involve-CST3', 'Aneuploidy-expressed-TP53', 'APOE-enhance-Alzheimer Disease', 'APOE-study-Alzheimer Disease', 'Kidney Diseases-employed-SLC22A2', 'GAST-associated-Hypercalcemia', 'Hypercalcemia-associated-GAST', 'INS-observed-Obesity', 'Inflammation-increase-HSP90AA1', 'CRP-increase-Inflammation', 'CRP-inhibit-Encephalomyelitis, Autoimmune, Experimental', 'LPAR3-downregulated-Progeria', 'LPAR3-identify-Progeria', 'Inflammation-assessed-CRP', 'Fractures, Bone-combine-SPP1', 'SPP1-function-Protein-Energy Malnutrition', 'STAT3-involved-Kidney Diseases', 'Glycogen Storage Disease Type II-inhibit-VEGFA', 'GH1-occur-Gynecomastia', 'CST3-defined-Renal Insufficiency, Chronic', 'PSEN2-examine-Alzheimer Disease', 'Alzheimer Disease-lack-APOE', 'GRN-induced-Infections', 'HIV Infections-increase-GRN', 'MAPT-reflect-Memory Disorders', 'MAPT-spread-Alzheimer Disease', 'INS-regulate-Glucose Metabolism Disorders', 'KL-protect-Demyelinating Diseases', 'TNMD-expressed-Fasciculation', 'INS-administered-Delirium', 'INS-reduce-Delirium', 'SIRT1-lead-Vitiligo', 'Carcinoma, Pancreatic Ductal-contribute-ALOX12', 'SIRT1-protect-Vitiligo', 'Hypothalamic Diseases-coincide-SST', 'Hypothalamic Diseases-involved-GH1', 'FGF23-predict-Cardiovascular Diseases', 'SIRT7-reduce-Neoplasms', 'ASXL1-associated-Death', 'Death-associated-ASXL1', 'PRRT2-implicated-Alzheimer Disease', 'SQSTM1-co-localize-Hematologic Diseases', 'Diabetes Mellitus-varied-ACE', 'ACE-varied-Diabetes Mellitus', 'Diabetes Mellitus-exert-ACE', 'Parkinson Disease-exhibit-ERCC1', 'CRP-promote-Calcinosis', 'Abdominal Pain-improve-GPT', 'Alzheimer Disease-supported-MAPT', 'Hypothalamic Neoplasms-lead-GH1', 'PAX6-lead-Abnormalities, Drug-Induced', 'Mastocytosis, Systemic-activated-INS', 'Heart Failure-tolerate-ACE', 'Osteosarcoma-simulated-SIRT6', 'APOE-associate-Alzheimer Disease', 'Alzheimer Disease-associate-APOE', 'APOE-underrepresented-Alzheimer Disease', 'Neoplasms-known-BMI1', 'BMI1-linked-Neoplasms', 'Neoplasms-associated-TERF1', 'TERF1-associated-Neoplasms', 'CDA-differentiate-Arthritis, Rheumatoid', 'Obesity-show-INS', 'SLC17A5-associated-Death', 'Death-associated-SLC17A5', 'NFE2L2-tested-Pheochromocytoma', 'SPP1-associated-Hip Fractures', 'Hip Fractures-associated-SPP1', 'Autoimmune Diseases-potentiate-CD4', 'CISD2-play-Neoplasms', 'CISD2-related-Neoplasms', 'CISD2-mediate-Neoplasms', 'AVP-contribute-Nocturia', 'AICDA-correlated-Inflammatory Bowel Diseases', 'AICDA-contribute-Inflammatory Bowel Diseases', 'Neurodegenerative Diseases-occur-APOE', 'Hypoparathyroidism-defined-PTH', 'Inflammation-regulate-FOXP3', 'TRH-associated-Goiter, Nodular', 'Goiter, Nodular-associated-TRH', 'Lung Neoplasms-associated-GSTM1', 'GSTM1-associated-Lung Neoplasms', 'NEFL-compared-Heredodegenerative Disorders, Nervous System', 'SST-involved-Alzheimer Disease', 'NR4A2-affected-Parkinson Disease', 'NR4A2-associated-Tauopathies', 'Tauopathies-associated-NR4A2', 'Colitis, Ulcerative-defined-TNF', 'HSF1-support-Neoplasms', 'Neoplasms-confer-TOP1', 'SRSF3-mislocalize-Carcinoma, Hepatocellular', 'Hypogonadism-altered-SHBG', 'TERT-associated-Neoplasms', 'Neoplasms-associated-TERT', 'IFI16-contribute-Heart Arrest', 'MAPT-prevent-Alzheimer Disease', 'MAPT-trigger-Neurodegenerative Diseases', 'CRP-measure-Cardiovascular Diseases', 'ALB-associated-Muscle Cramp', 'Muscle Cramp-associated-ALB', 'IGF2-occur-Neoplasms', 'IGF2-serve-Prostatic Neoplasms', 'ADAM10-include-Alzheimer Disease', 'Osteoporotic Fractures-belong-TGFB1', 'PRDX4-expressed-Ovarian Neoplasms', 'MC1R-modulate-Pigmentation Disorders', 'Ovarian Neoplasms-expressed-PRDX4', 'RAB8A-found-Carcinoma, Non-Small-Cell Lung', 'RAB8A-increase-Carcinoma, Non-Small-Cell Lung', 'XRCC5-impact-Neoplasms', 'PARP1-control-Arbovirus Infections', 'CD4-associated-Atherosclerosis', 'Atherosclerosis-associated-CD4', 'S100A4-facilitate-Constriction, Pathologic', 'Adrenal Insufficiency-investigate-BGLAP', 'NPPC-associated-Hypotension', 'Hypotension-associated-NPPC', 'NPPC-precede-Hypotension', 'CYBB-shown-Death', 'SLC5A2-decline-Kidney Diseases', 'Coronary Artery Disease-subjected-PKP2', 'PINK1-linked-Parkinson Disease', 'CD79A-noted-Hypothalamic Neoplasms', 'SOST-lead-Bone Neoplasms', 'RBP4-involved-Atherosclerosis', 'MME-cause-Nerve Degeneration', 'MME-predispose-Alzheimer Disease', 'CRP-increased-HIV Infections', 'LMNA-underlie-Progeria', 'MVP-associated-Leukemia, Myeloid, Acute', 'Leukemia, Myeloid, Acute-associated-MVP', 'CRP-exhibit-Death', 'Leukemia, Myeloid, Acute-benefit-ABCB1', 'AICDA-associated-Carcinoma, Squamous Cell', 'Carcinoma, Squamous Cell-associated-AICDA', 'SOD1-characterized-Motor Neuron Disease', 'Diabetes Mellitus, Type 2-find-CD4', 'MAPT-cause-Heredodegenerative Disorders, Nervous System', 'Glucose Metabolism Disorders-decrease-INS', 'Neoplasms-transfected-GRN', 'HOXB7-associated-Osteogenesis Imperfecta', 'Osteogenesis Imperfecta-associated-HOXB7', 'GRN-introduced-Neoplasms', 'APOE-promote-Alzheimer Disease', 'Alzheimer Disease-contain-SST', 'KL-present-Neoplasms', 'CDKN2A-associate-Renal Insufficiency, Chronic', 'Renal Insufficiency, Chronic-associate-CDKN2A', 'APOE-assemble-Death', 'Liver Cirrhosis-defined-GPT', 'CRP-associated-Dementia', 'Dementia-associated-CRP', 'CRP-fail-Inflammation', 'CRP-occur-Inflammation', 'CRP-report-Dementia', 'CRP-confer-Dementia', 'BDNF-predispose-Alzheimer Disease', 'XPC-develop-Lung Neoplasms', 'FTO-up-regulated-Osteoporosis', 'Death-estimate-APOE', 'TRPA1-become-Aneurysm', 'TRPA1-play-Aneurysm', 'MAPT-cleave-Alzheimer Disease', 'CRP-evaluated-Chronic Kidney Disease-Mineral and Bone Disorder', 'FOXA1-involved-Neoplasms', 'FOXA1-regulate-Neoplasms', 'Inflammation-associated-DIRAS3', 'DIRAS3-associated-Inflammation', 'MAPK8-bring-Nerve Degeneration', 'Insulin Resistance-attributed-INS', 'MAPT-formed-Alzheimer Disease', 'MAPT-moving-Dementia', 'Kidney Diseases-related-PTH', 'Kidney Diseases-explained-PTH', 'Progeria-carry-LMNA', 'INS-predict-Inflammation', 'APOE-use-Delirium', 'PCSK9-resected-Aortic Aneurysm, Abdominal', 'PCSK9-indicated-Cardiovascular Diseases', 'TERT-drive-Pulmonary Disease, Chronic Obstructive', 'TERT-contribute-Pulmonary Disease, Chronic Obstructive', 'TERT-implicated-Pulmonary Disease, Chronic Obstructive', 'PNPLA6-identified-Motor Neuron Disease', 'PNPLA6-designated-Motor Neuron Disease', 'ATP6V0A2-developed-Asthma', 'Primary Ovarian Insufficiency-secrete-GGH', 'PZP-increased-Neoplasms', 'Diabetes Mellitus-inject-INS', 'Atrophy-learn-INS', 'CD8A-drive-Infections', 'CDKN2A-measure-Neoplasms', 'KLK3-correlated-Prostatitis', 'CDKN2A-undergo-Neoplasms', 'Hypertension-improve-INS', 'TCN2-influence-Immunologic Deficiency Syndromes', 'Prostatic Neoplasms-use-KLK3', 'SERPINA1-affected-Myocardial Infarction', 'INS-decreased-Werner Syndrome', 'PRL-divide-Dementia', 'LMNA-lead-Myalgia', 'Alzheimer Disease-modeled-APOE', 'ERBB2-overexpressed-Breast Neoplasms', 'KLF6-recapitulate-Leukemia', 'Breast Neoplasms-correlated-EREG', 'CRP-increase-Pneumonia', 'Astrocytoma-guided-MGMT', 'Respiratory Tract Infections-occur-CRP', 'ZMPSTE24-yield-Progeria', 'ZMPSTE24-result-Progeria', 'Hypertension, Renovascular-observed-REN', 'RECQL4-increase-Rothmund-Thomson Syndrome', 'FOXO3-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-FOXO3', 'PRKAA2-improve-Aneurysm', 'TLR2-suffer-Alzheimer Disease', 'PRKAA2-control-Neurodegenerative Diseases', 'ATG16L1-associated-Neoplasms', 'Neoplasms-associated-ATG16L1', 'ADCY4-decrease-Cardiomegaly', 'ADCY4-contribute-Heart Failure', 'KL-linked-Chronic Kidney Disease-Mineral and Bone Disorder', 'SIRT1-induce-Osteosarcoma', 'Alzheimer Disease-known-MAPT', 'RNF4-improve-Neoplasms', 'LCN2-predict-Osteoporotic Fractures', 'Pulmonary Disease, Chronic Obstructive-show-TRIM16', 'TRIM16-involved-Lysosomal Storage Diseases', 'S100A1-increase-Dementia', 'CCR5-associated-Prostatic Neoplasms', 'Prostatic Neoplasms-associated-CCR5', 'PRKN-decreased-Alzheimer Disease', 'CYP3A4-influence-Prostatic Neoplasms', 'CYP3A4-associated-Neoplasm Metastasis', 'Neoplasm Metastasis-associated-CYP3A4', 'Alzheimer Disease-happen-MAPT', 'GLB1-prevent-Uterine Cervical Neoplasms', 'Inflammation-induced-MAPT', 'Renal Insufficiency-switch-INS', 'C3-include-Inflammation', 'IGFBP7-targeting-Alzheimer Disease', 'SIRT1-involve-Communicable Diseases', 'Hemochromatosis-carry-HFE', 'CERS2-inhibit-Carcinoma, Hepatocellular', 'MAPT-inhibit-Neurodegenerative Diseases', 'ACE-promote-Cardiomyopathy, Hypertrophic', 'Neoplasms-analysed-EREG', 'Pulmonary Disease, Chronic Obstructive-linked-MTOR', 'SIRT1-detected-Neoplasms', 'MTOR-approved-Neoplasms', 'MTOR-treat-Neoplasms', 'TNFRSF21-associated-Seizures', 'Seizures-associated-TNFRSF21', 'APOE-include-Dementia', 'Atherosclerosis-correlate-NOX4', 'PARP1-discriminate-Prostatic Neoplasms', 'Neoplasms-secreted-VEGFA', 'SIRT1-overexpressed-Neoplasms', 'Breast Neoplasms-promote-SIRT1', 'Neoplasms-confer-WRN', 'POMC-explain-Neoplasms', "Sjogren's Syndrome-show-GNL3", "ABCG2-expressed-Sjogren's Syndrome", 'CAT-increased-Ataxia Telangiectasia', 'INS-adapt-Hyperinsulinism', 'Alzheimer Disease-confer-LRRTM3', 'GPER1-employ-Cardiovascular Diseases', 'ANGPTL2-predict-Death', 'Cardiovascular Diseases-differ-PIK3R1', 'MUC1-expressed-Neoplasms', 'TNF-occur-Weight Loss', 'RECQL4-observed-Breast Neoplasms', 'KLK3-require-Prostatic Neoplasms', 'Neoplasms-defined-KLK3', 'Neoplasms-detected-KLK3', 'AR-establish-Neoplasms', 'MAPT-known-Alzheimer Disease', 'MAPT-seen-Diffuse Neurofibrillary Tangles with Calcification', 'VWF-treat-Multiple Myeloma', 'CRP-assessed-Fractures, Bone', 'Poisoning-protect-ACHE', 'TXNIP-associated-Myotonic Dystrophy', 'Myotonic Dystrophy-associated-TXNIP', 'Alzheimer Disease-focus-MAPT', 'Neoplasms-derived-VEGFA', 'VEGFA-demonstrated-Neoplasms', 'VEGFA-understand-Neoplasms', 'KL-enhance-Kidney Failure, Chronic', 'KL-show-Vascular Calcification', 'ACE-improve-Ventricular Dysfunction, Left', 'LMNB1-observed-Progeria', 'CRP-analyzed-Carcinoma, Non-Small-Cell Lung', 'Arthritis, Rheumatoid-increase-CRP', 'Death-compare-ACE', 'LGMN-play-Atherosclerosis', 'COL17A1-given-Alzheimer Disease', 'Cartilage Diseases-increase-HSPB1', 'Aortic Stenosis, Supravalvular-include-ELN', 'Williams Syndrome-appear-ELN', 'ELN-contain-Williams Syndrome', 'Williams Syndrome-contain-ELN', 'TNFSF11-influence-Bone Diseases', 'TNFSF11-associated-Bone Diseases', 'Bone Diseases-associated-TNFSF11', 'AR-expressed-Prostatic Neoplasms', 'TERF2-increase-Peripheral Arterial Disease', 'ATF3-found-Prostatic Neoplasms', 'CHMP1B-screened-Ophthalmoplegia, Chronic Progressive External', 'BDNF-degenerate-Alzheimer Disease', 'BDNF-reported-Alzheimer Disease', 'SLC39A2-play-Carotid Artery Diseases', 'CRP-collected-Myoclonic Epilepsies, Progressive', 'Neoplasms-increase-STIP1', 'SPP1-seen-Drug-Related Side Effects and Adverse Reactions', 'RAB10-identified-Alzheimer Disease', 'RAB10-associated-Alzheimer Disease', 'Alzheimer Disease-associated-RAB10', 'DRD2-investigated-Alzheimer Disease', 'Hereditary Breast and Ovarian Cancer Syndrome-incorporate-TP53', 'INS-increase-Diabetes Mellitus', 'FLT3-treat-Leukemia, Myeloid, Acute', 'Sclerosis-noted-MAPT', 'CTSC-increase-Glioma', 'CTSC-associated-Glioma', 'Glioma-associated-CTSC', 'LEP-use-Cardiovascular Diseases', 'GDF11-reveal-Pulmonary Disease, Chronic Obstructive', 'APOE-affect-Alzheimer Disease', 'SIRT1-focus-Atherosclerosis', 'CRP-measured-Inflammation', 'SIRT1-exposed-Pulmonary Disease, Chronic Obstructive', 'SLC11A2-observed-Parkinson Disease', 'KLK3-done-Prostatic Neoplasms', 'Melanoma-contain-GLO1', 'EPO-reflect-Pulmonary Disease, Chronic Obstructive', 'Ovarian Neoplasms-found-LHCGR', 'Ovarian Neoplasms-identify-LHCGR', 'KL-serve-Dwarfism, Pituitary', 'LRP1-reduce-Alzheimer Disease', 'MAPT-associate-Canavan Disease', 'Canavan Disease-associate-MAPT', 'Hyperparathyroidism, Secondary-characterized-PTH', 'NOX5-express-Hypertension', 'SHBG-represent-Osteoporosis', 'Peripheral Arterial Disease-improve-INS', 'NOX5-represent-Hypertension', 'CRP-find-Alzheimer Disease', 'Dementia-studied-CRP', 'INS-result-Mitochondrial Diseases', 'NEFL-predict-Dementia', 'Skin Diseases-caused-FLG', 'VDR-contribute-Muscular Atrophy', 'MAPT-observed-Brain Injuries, Traumatic', 'POSTN-promote-Fibrosis', 'Drug-Related Side Effects and Adverse Reactions-exert-ACHE', 'SHBG-assessed-Fractures, Bone', 'SHBG-provide-Fractures, Bone', 'Malaria-administered-TLR9', 'INS-delivered-Diabetes Mellitus', 'ANG-involved-Neoplasm Metastasis', 'ANG-participate-Choroidal Neovascularization', 'Neoplasms-exhibit-KLK3', 'Chorioretinitis-internalize-ANG', 'Diabetes Mellitus-inhale-INS', 'Coronary Artery Disease-indicate-ANGPTL2', 'Atherosclerosis-exhibit-POMC', 'KLK3-detect-Neoplasms', 'Atherosclerosis-administered-POMC', 'KL-become-Arthritis, Rheumatoid', 'KL-down-regulated-Arthritis, Rheumatoid', 'Muscular Diseases-associated-RYR1', 'RYR1-associated-Muscular Diseases', 'RYR1-present-Muscle Weakness', 'DCX-observed-Dementia, Vascular', 'INS-contribute-Diabetes Mellitus, Type 2', 'SIRT1-foreseen-Cardiovascular Diseases', 'INS-modulate-Thoracic Outlet Syndrome', 'Infections-monitored-GH1', 'EFEMP1-regulate-Osteoarthritis', 'ALB-associated-Hypertension', 'Hypertension-associated-ALB', 'Rothmund-Thomson Syndrome-include-RECQL4', 'Rothmund-Thomson Syndrome-facilitate-RECQL4', 'CRP-reported-Sleep Wake Disorders', 'RECQL4-regulated-Werner Syndrome', 'GRN-treat-Neurodegenerative Diseases', 'Supranuclear Palsy, Progressive-increase-GRN', 'RECQL4-localized-Werner Syndrome', 'VWF-used-Hemorrhage', 'VWF-treat-Hemorrhage', 'Stomach Neoplasms-depend-ELAVL1', 'Stomach Neoplasms-obtained-ELAVL1', 'LMNA-associated-Muscular Diseases', 'Muscular Diseases-associated-LMNA', 'LMNA-termed-Muscular Diseases', 'SUN1-correct-Progeria', 'FGF23-cause-Cardiomyopathy, Hypertrophic', 'FGF23-found-Cardiovascular Diseases', 'Sarcopenia-ordered-ALB', 'Insulin Resistance-reversed-INS', 'Fractures, Bone-heal-PTH', 'PTH-prevent-Fractures, Bone', 'TNF-examine-Prostatic Neoplasms', 'SIRT1-extend-Intellectual Disability', 'HS3ST4-enhance-Drug-Related Side Effects and Adverse Reactions', 'Drug Hypersensitivity-lack-WRN', 'Infections-enhanced-HS3ST4', 'HS3ST4-investigate-Infections', 'VDR-exhibit-Progeria', 'RHOT1-rescue-Parkinson Disease', 'RHOT1-situate-Parkinson Disease', 'CPLANE1-rearranged-Neoplasms', 'CPLANE1-reduced-Adenocarcinoma', 'CPLANE1-express-Neoplasms', 'CPLANE1-reverse-Neoplasms', 'Colonic Neoplasms-use-FAAH', 'Colonic Neoplasms-obtained-FAAH', 'COG2-indicate-Metabolic Diseases', 'Carcinoma, Hepatocellular-transfected-RGN', 'Multiple Myeloma-secrete-FGF23', 'Multiple Myeloma-respond-FGF23', 'Multiple Myeloma-stain-KL', 'FGF23-increased-Multiple Myeloma', 'MLH1-predispose-Neoplasms', 'TSPO-studied-Alzheimer Disease', 'COL17A1-show-Pruritus', 'PER2-compared-HIV Infections', 'HIV Infections-involved-PER2', 'DPP4-enhanced-Obesity', 'FLNC-possess-Neurodegenerative Diseases', 'Alzheimer Disease-based-OXT', 'RPP30-affect-Neoplasms', 'Alzheimer Disease-correspond-LEP', 'TMEM106B-result-Drug-Related Side Effects and Adverse Reactions', 'SHBG-lack-Immunologic Deficiency Syndromes', 'DKC1-described-Dyskeratosis Congenita', 'OPRD1-associated-Alzheimer Disease', 'Alzheimer Disease-associated-OPRD1', 'CRELD2-develop-Fatty Liver', 'ROCK1-reduced-Neoplasms', 'PGC-indicate-Gastritis, Atrophic', 'NAT2-associated-Cataract', 'Cataract-associated-NAT2', 'S100A9-involved-Alzheimer Disease', 'S100A9-detected-Parkinson Disease', 'Alzheimer Disease-mimic-MAPT', 'Death, Sudden, Cardiac-increase-CST3', 'FLT3-approved-Leukemia, Myeloid, Acute', 'SHH-transduce-Carcinoma, Basal Cell', 'FOXM1-detected-Carcinoma, Basal Cell', 'Alzheimer Disease-play-APBB2', 'LEP-predict-Weight Gain', 'MSRB2-play-Alzheimer Disease', 'Neoplasms-regulate-CDKN3', 'VEGFA-used-Cerebrovascular Disorders', 'SIRT1-activate-Neoplasms', 'COL17A1-obtained-Dementia', 'Rothmund-Thomson Syndrome-caused-RECQL4', 'SIRT1-inhibit-Neoplasms', 'SIRT1-promote-Neoplasms', 'MTOR-implicated-Kidney Diseases', 'Inflammation-enhance-TNF', 'FNDC5-cause-Osteoporosis', 'TNFAIP3-observed-Lymphoma', 'Glycogen Storage Disease Type II-carry-CFH', 'MAPT-underlie-Psychoses, Substance-Induced', 'KL-result-Death', 'KL-reduced-Renal Insufficiency, Chronic', 'KDM1A-utilize-Carcinoma, Squamous Cell', 'INHBE-involved-Alzheimer Disease', 'SIRT6-combat-Atherosclerosis', 'BMP7-treat-Muscular Disorders, Atrophic', 'SIRT6-regulate-Atherosclerosis', 'SFRP2-augment-Melanoma', 'CRP-determine-Cerebral Infarction', 'PYCR1-resemble-Progeria', 'CRP-rule-Infections', 'AR-associated-Dry Eye Syndromes', 'Dry Eye Syndromes-associated-AR', 'Prediabetic State-manifest-INS', 'INS-reduce-Diabetes Mellitus, Type 2', 'CRP-evaluate-Alzheimer Disease', 'MGP-involved-Vascular Calcification', 'MAOB-treat-Parkinson Disease', 'CRP-suggest-Alzheimer Disease', 'ABCC9-implicated-Heredodegenerative Disorders, Nervous System', 'Liver Cirrhosis-modulate-CYP2C19', 'CFH-associated-Blindness', 'Blindness-associated-CFH', 'YAP1-serve-Cardiovascular Diseases', 'ELN-associated-Cerebrovascular Disorders', 'Cerebrovascular Disorders-associated-ELN', 'ELN-become-Neurologic Manifestations', 'Parkinson Disease-caused-PINK1', 'NES-originate-Neoplasms', 'ATM-remain-Heart Arrest', 'NES-expressed-Neoplasms', 'Atrial Fibrillation-increased-PIEZO1', 'SIRT1-known-Neurodegenerative Diseases', 'SHBG-provide-Diabetes Mellitus', 'PAK1-exhibit-Lung Neoplasms', 'INS-employ-Congenital Hyperinsulinism', 'Skin Diseases-associated-MMP1', 'MMP1-associated-Skin Diseases', 'NDRG2-study-Alzheimer Disease', 'INS-contribute-Sarcopenia', 'CCL11-augment-Vascular Calcification', 'PARP1-identified-Diabetic Neuropathies', 'CCL11-increase-Calcinosis', 'CCL11-represent-Cardiovascular Diseases', 'Alzheimer Disease-assessed-GFAP', 'GFAP-decrease-Alzheimer Disease', 'AFP-related-Carcinoma, Hepatocellular', 'AFP-exclude-Carcinoma, Hepatocellular', 'Genetic Diseases, Inborn-described-GGH', 'SIRT1-protect-Atherosclerosis', 'TIMM13-show-Alzheimer Disease', 'CD4-influence-Ovarian Diseases', 'EGFR-reduce-Prostatic Hyperplasia', 'NFKB1-follow-Infections', 'GPT-used-Metabolic Syndrome', 'CDKN2A-decreased-Alzheimer Disease', 'Obesity-obtained-INS', 'PINK1-cause-Parkinson Disease', 'Polycystic Ovary Syndrome-found-SHBG', 'Leukemia, Erythroblastic, Acute-receive-EPO', 'Pruritus-associated-ALB', 'ALB-associated-Pruritus', 'APOE-give-Cardiovascular Diseases', 'APOE-stand-Cardiovascular Diseases', 'Renal Insufficiency, Chronic-exceed-FGF23', 'KLF15-reduced-Aortic Aneurysm', 'APOE-studied-Alzheimer Disease', 'Shock-involved-VCP', 'KL-associated-Atherosclerosis', 'Atherosclerosis-associated-KL', 'RECQL4-involved-Neoplasms', 'GHRH-become-Dwarfism, Pituitary', 'GHRH-combine-Dwarfism, Pituitary', 'Cockayne Syndrome-suggest-SYT9', 'BACE1-increased-Alzheimer Disease', 'Alzheimer Disease-accelerate-CDK5', 'NEFL-appear-Brain Injuries', 'NEFL-indicate-HIV Infections', 'MBD2-treat-Asthma', 'Infections-localised-XPO1', 'MBD2-downregulate-Asthma', 'INS-inhibit-Acromegaly', 'AZGP1-increase-Weight Loss', 'CD8A-divide-Infections', 'NRXN3-known-Alzheimer Disease', 'NRXN3-carry-Alzheimer Disease', 'Progeria-compare-LMNA', 'CDC26-lack-Aneuploidy', 'Prostatic Neoplasms-shown-MTOR', 'Alzheimer Disease-collaborate-APOE', 'KL-involved-Bone Neoplasms', 'APOE-exposed-Alzheimer Disease', 'FASLG-indicate-Drug-Related Side Effects and Adverse Reactions', 'GH1-characterized-Obesity', 'GH1-studied-Obesity', 'Parkinson Disease-undergo-SLC18A2', 'Parkinson Disease-estimate-SLC18A2', 'RELN-generate-Dementia', 'RELN-considered-Alzheimer Disease', 'Conjunctival Diseases-supplement-NGF', 'CRP-measure-Infections', 'KLK3-show-Prostatic Neoplasms', 'INS-promote-Communicable Diseases', 'Diabetes Mellitus, Type 2-consist-INS', 'INS-generalized-Diabetes Mellitus, Type 2', 'INS-underutilized-Diabetes Mellitus', 'Creutzfeldt-Jakob Syndrome-show-PRNP', 'PRNP-seen-Alzheimer Disease', 'ADA-determined-Chronic Disease', 'MTOR-relieve-Inflammation', 'SIRT7-observed-Neoplasms', 'SIRT7-suggest-Neoplasms', 'SIRT7-promote-Neoplasms', 'SIRT7-stabilize-Neoplasms', 'SIRT7-control-Neoplasms', 'BDNF-measure-Dementia', 'BDNF-observed-Dementia', 'MAPT-develop-Diffuse Neurofibrillary Tangles with Calcification', 'REN-tend-Hypertension', 'Neoplasms-over-expressed-ERBB2', 'SPI1-induce-Leukemia, Myeloid, Acute', 'WRN-exhibit-Neoplasms', 'TP53-inactivated-Neoplasms', 'Glucose Metabolism Disorders-involved-INS', 'AREG-targeting-Neoplasms', 'AREG-minimize-Neoplasms', 'PTGS2-encoded-Osteoarthritis', 'CEMIP-observed-Death', 'Breast Neoplasms-express-CEMIP', 'Inflammation-identify-CXCL11', 'Breast Neoplasms-characterized-ERBB2', 'IL6-approved-Arthritis, Rheumatoid', 'GFAP-lack-Heredodegenerative Disorders, Nervous System', 'HIF1A-discuss-Alzheimer Disease', 'CD28-result-Alzheimer Disease', 'Hemochromatosis-caused-HFE', 'FGF7-increase-Epidermal Cyst', 'TGFA-decreased-Alzheimer Disease', 'CRP-decrease-Cardiovascular Diseases', 'ATXN1-act-Alzheimer Disease', 'PRKAB1-support-Glucose Metabolism Disorders', 'PRKAB1-treat-Metabolic Diseases', 'Hypertrophy-contain-TAC3', 'TAC3-participate-Hypothalamic Diseases', 'EGFR-result-Drug-Related Side Effects and Adverse Reactions', 'GH1-increase-Death', 'Cataract-carried-TF', 'KL-increase-Diabetes Mellitus', 'GNL3-expressed-Neoplasms', 'SFRP1-investigated-Adenoma', 'REN-associated-Kidney Diseases', 'Kidney Diseases-associated-REN', 'SFRP1-hypermethylated-Adenoma', 'ACHE-screen-Drug-Related Side Effects and Adverse Reactions', 'SOD1-reproduce-Amyotrophic Lateral Sclerosis', 'BGLAP-evaluated-Osteoporosis', 'Chiari-Frommel Syndrome-lead-PRL', 'Chiari-Frommel Syndrome-block-PRL', 'CSF3-associated-Neutropenia', 'Neutropenia-associated-CSF3', 'CSF3-prove-Neutropenia', 'PRL-exacerbate-Osteoporosis', 'MTOR-cause-Alzheimer Disease', 'NPPA-mediated-Hypertension', 'BCHE-investigate-Cerebral Amyloid Angiopathy', 'WRN-give-Neoplasms', 'CD4-differ-Infections', 'RIPK1-rescue-Nerve Degeneration', 'RIPK1-play-Alzheimer Disease', 'PPARG-revealed-Atherosclerosis', 'SIRT6-linked-Obesity', 'SPP1-implicated-Vascular Calcification', 'CRP-suspect-Pneumonia', 'Cystic Fibrosis-code-CFTR', 'Cystic Fibrosis-caused-CFTR', 'Cystic Fibrosis-assist-CFTR', 'CD8A-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-CD8A', 'PABPN1-induce-Abnormalities, Drug-Induced', 'Death-associated-GGTLC3', 'GGTLC3-associated-Death', 'EPO-take-Sepsis', 'Cardiovascular Diseases-mediate-APOB', 'SYP-reduced-Sclerosis', 'MAPK1-confirmed-Kidney Diseases', 'EWSR1-associated-Brain Diseases', 'Brain Diseases-associated-EWSR1', 'Coronary Artery Disease-detected-SMN1', 'Headache-contrast-INS', 'GDF15-associated-Inflammation', 'Inflammation-associated-GDF15', 'Parathyroid Neoplasms-oversecrete-PTH', 'GLRX3-involved-Neoplasms', 'NOTCH1-treat-Aneurysm', 'MYC-associated-Glucose Metabolism Disorders', 'Glucose Metabolism Disorders-associated-MYC', 'VEGFA-permit-Neoplasms', 'KL-increase-Carcinoma, Hepatocellular', 'MUC1-act-Colorectal Neoplasms', 'ACE2-thought-Infections', 'MAPT-accompanied-Memory Disorders', 'ACE2-play-Cardiovascular Diseases', 'Corneal Dystrophies, Hereditary-caused-CHST6', 'INS-represent-Diabetes Mellitus', 'MAPT-linked-Neurodegenerative Diseases', 'AQP4-associated-Alzheimer Disease', 'Alzheimer Disease-associated-AQP4', 'TTR-form-Amyloidosis', 'Amyloidosis-degrade-TTR', 'NFE2L2-attenuated-Alzheimer Disease', 'IL10-compare-Neurocysticercosis', 'REN-show-Hypertension', 'RBM14-relocalize-Infections', 'PTHLH-support-Osteoarthritis', 'TERF2-contribute-Arbovirus Infections', 'FOXN1-involved-Neoplasms', 'FOXN1-result-Neuroectodermal Tumor, Melanotic', 'Atrophy-known-CD4', 'CRP-associated-Psychomotor Disorders', 'Psychomotor Disorders-associated-CRP', 'SIRT6-regulate-Cardiovascular Diseases', 'CEACAM3-overexpressed-Adenocarcinoma', 'SIRT6-exhibit-Drug Hypersensitivity', 'SHBG-become-Obesity', 'Pigmentation Disorders-treated-NFE2L2', 'Bone Diseases, Metabolic-detect-PTH', 'Osteomalacia-reflect-PTH', 'Sleep Apnea, Obstructive-increase-SIRT1', 'KLK3-rose-Neoplasms', 'SIRT6-expressed-Bone Marrow Diseases', 'IBA57-associated-Mitochondrial Diseases', 'Mitochondrial Diseases-associated-IBA57', 'TNFRSF11B-detected-Prolactinoma', 'INS-evaluated-Diabetes Mellitus', 'POMC-assayed-Diabetes Mellitus', 'INS-attributed-Hypoglycemia', 'SIRT1-act-Neoplasms', 'SIRT1-reduced-Skin Neoplasms', 'Cystic Fibrosis-affect-CFTR', 'APOE-underlie-Alzheimer Disease', 'Cockayne Syndrome-underlie-ERCC6', 'VGF-considered-Obesity', 'Inflammation-reduced-PTX3', 'SIRT1-serve-Osteoporosis', 'ACE-withhold-Renal Insufficiency', 'ACE-improve-Renal Insufficiency', 'REST-associated-Neurodegenerative Diseases', 'Neurodegenerative Diseases-associated-REST', 'TSC2-associated-Alzheimer Disease', 'Alzheimer Disease-associated-TSC2', 'DLG3-reduced-Alzheimer Disease', 'SIRT1-respond-Multiple Chronic Conditions', 'Neurodegenerative Diseases-induce-TLR4', 'CST3-associated-Heart Failure', 'Heart Failure-associated-CST3', 'PRKAB1-protect-Diabetes Mellitus', 'OTX2-associated-Retinal Diseases', 'Retinal Diseases-associated-OTX2', 'SHBG-predict-Metabolic Syndrome', 'WRN-suggested-Werner Syndrome', 'CCL5-detected-Alzheimer Disease', 'PDGFRB-cause-Gingival Overgrowth', 'TP53-protect-Neoplasms', 'Alzheimer Disease-coexist-MAPT', 'Atherosclerosis-modify-MAPT', 'Parkinson Disease-carry-SNCA', 'Plaque, Amyloid-consist-EFEMP1', 'HTT-expressed-Huntington Disease', 'NEFL-predict-Alzheimer Disease', 'COMP-associated-Osteoarthritis', 'Osteoarthritis-associated-COMP', 'SOD1-reported-Brain Ischemia', 'Dyskeratosis Congenita-contain-PRDM8', 'PRDM8-support-Bone Marrow Failure Disorders', 'S100A7-developed-Alzheimer Disease', 'ABCG1-play-Myocardial Infarction', 'REN-include-Acute Kidney Injury', 'Alzheimer Disease-used-MAPT', 'Drug-Related Side Effects and Adverse Reactions-inhibit-ACHE', 'MAPT-link-Alzheimer Disease', 'SUMO1-associated-Alzheimer Disease', 'Alzheimer Disease-associated-SUMO1', 'SUMO1-increased-Dementia', 'RHOA-upregulated-Carcinoma, Hepatocellular', 'RHOA-serve-Carcinoma, Hepatocellular', 'SIRT1-play-Osteoarthritis', 'ALB-reveal-Liver Failure', 'Liver Failure-induce-ALB', 'SIRT1-involved-Osteoarthritis', 'MDM2-activate-Infections', 'MAP2-observed-Glycogen Storage Disease Type II', 'AGER-contribute-Osteoarthritis', 'CDKN2A-promote-Huntington Disease', 'MSRA-implicate-Cataract', 'HDAC9-increase-Leukoencephalopathies', 'Neoplasms-associated-MAD1L1', 'MAD1L1-associated-Neoplasms', 'DNMT3A-examine-Neoplasms', 'SPP1-affect-Kidney Calculi', 'DNER-induced-Infections', 'KL-participate-Glucose Metabolism Disorders', 'Alzheimer Disease-expressed-ADAM10', 'Alzheimer Disease-published-ADAM10', 'Sarcopenia-progress-INS', 'Neoplasms-reduce-TP53', 'APOE-involved-Keratitis, Dendritic', 'MAPT-play-Neurodegenerative Diseases', 'Myocardial Infarction-predict-INS', 'GJA4-involved-Myocardial Infarction', 'ICAM1-involved-Neoplasms', 'TNIP1-enhance-Inflammation', 'KL-contribute-Carcinoma, Hepatocellular', 'Malnutrition-exhibit-BDNF', 'KL-known-Neoplasms', 'Tics-seem-VDR', 'GGH-stimulate-Hypogonadism', 'DPP4-associated-Inflammation', 'Inflammation-associated-DPP4', 'SOD2-downregulated-Cartilage Diseases', 'HMGB1-play-Death', 'HMGB1-highlight-Sepsis', 'APOD-examined-Alzheimer Disease', 'Diabetes Mellitus-decrease-ADIPOQ', 'ADIPOQ-develop-Diabetes Mellitus', 'LMNA-identified-Neurodegenerative Diseases', 'BMP2-diagnosed-Osteoporosis', 'WRN-demonstrate-Neoplasms', 'APOE-play-Dementia', 'Heart Arrest-induced-WRN', 'WRN-induce-Death', 'CRP-perform-Sepsis', 'CRP-differentiate-Sepsis', 'Hypertension, Renovascular-suspected-REN', 'REN-range-Hypertension', 'Scleroderma, Systemic-followed-BAX', 'NAMPT-identified-Carcinoma, Hepatocellular', 'NAMPT-display-Carcinoma, Hepatocellular', 'Angina Pectoris-increase-INS', 'NAMPT-considered-Neoplasms', 'NAMPT-upregulated-Neoplasms', 'Dementia-associated-MAPK8', 'MAPK8-associated-Dementia', 'Drug-Related Side Effects and Adverse Reactions-confer-SIRT3', 'EGF-diagnosed-Carcinoma, Non-Small-Cell Lung', 'FOXO1-associated-Death', 'Death-associated-FOXO1', 'INS-known-Cardiac Output, High', 'INS-suppress-Cardiac Output, High', 'SARM1-identified-Wallerian Degeneration', 'PNPLA6-trigger-Nerve Degeneration', 'SARM1-promote-Nerve Degeneration', 'CD5-observed-Leukemia, Lymphoid', 'KCNJ2-increase-Atrial Fibrillation', 'Werner Syndrome-lack-WRN', 'Muscle Weakness-precede-INS', 'MAPT-lead-Nerve Degeneration', 'SIRT6-play-Neoplasms', 'SIRT6-promote-Neoplasms', 'ACLY-function-Neoplasms', 'SIRT6-suppress-Neoplasm Metastasis', 'LEP-show-Dementia', 'APOD-induce-Heart Arrest', 'Alzheimer Disease-used-APOE', 'MTOR-treat-Alzheimer Disease', 'MTOR-become-Alzheimer Disease', 'MAPT-highlight-Alzheimer Disease', 'Aneurysm-express-AGER', 'FNDC5-reduce-Inflammation', 'CD8A-compare-Infections', 'CD8A-contain-Infections', 'CD8A-protect-Immunologic Deficiency Syndromes', 'ITGAL-hypomethylate-Lupus Erythematosus, Systemic', 'Infarction-contain-TREM2', 'Infarction-identify-TREM2', 'Alzheimer Disease-associated-TREM2', 'TREM2-associated-Alzheimer Disease', 'Diabetes Mellitus-begin-INS', 'Glucose Metabolism Disorders-assessed-INS', 'Dyslipidemias-reduce-CRP', 'CRP-used-Inflammation', 'Diabetes Mellitus-mediated-SHBG', 'WRN-learne-Werner Syndrome', 'PAX6-involved-Glucose Metabolism Disorders', 'CCND2-observed-Neoplasms', 'CCND2-recognized-Pancreatic Neoplasms', 'CCND2-detected-Pancreatic Neoplasms', 'CCND2-determined-Pancreatic Neoplasms', 'Pancreatic Neoplasms-methylated-CCND2', 'Atherosclerosis-aggravate-TNFRSF1A', 'WRN-contribute-Breast Neoplasms', 'KLK3-detected-Neoplasms', 'Prostatitis-omitted-KLK3', 'Neurodegenerative Diseases-reveal-MAPT', 'Shock-associated-DIRAS3', 'DIRAS3-associated-Shock', 'BACE1-demonstrate-Alzheimer Disease', 'ALB-used-Death', 'APOE-observed-Dyslipidemias', 'INS-produce-Diabetes Mellitus', 'TFPI-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-TFPI', 'MAPT-include-Dementia', 'CENPF-upregulated-Pancreatic Neoplasms', 'Death-found-ACE', 'BCHE-described-Weight Gain', 'Diabetes Mellitus-check-INS', 'CENPF-investigate-Pancreatic Neoplasms', 'Pain-link-COMT', 'KL-protect-Vascular System Injuries', 'Obesity-associated-TERF1', 'TERF1-associated-Obesity', 'Obesity-explained-TERF1', 'Macular Degeneration-disrupt-FBN2', 'FBN2-appear-Glycogen Storage Disease Type II', 'ELN-maintain-Hypotension', 'CALCA-studied-Cushing Syndrome', 'Cushing Syndrome-develop-POMC', 'CALCA-involved-Cushing Syndrome', 'Cushing Syndrome-show-CALCA', 'ALB-present-Death', 'WWOX-reduce-Neoplasms', 'WWOX-inhibit-Neoplasms', 'TLR2-reduced-Alzheimer Disease', 'HIV Infections-accompany-CD8A', 'Alzheimer Disease-exhibit-SST', 'CERS2-exhibited-Ovarian Neoplasms', 'TNFRSF1A-associated-Chronic Disease', 'Chronic Disease-associated-TNFRSF1A', 'Progeria-occur-LMNA', 'PIF1-protect-Neoplasms', 'AGER-review-Chronic Disease', 'AGER-target-Chronic Disease', 'AGER-mitigate-Chronic Disease', 'BCL2L11-upregulated-Osteoarthritis', 'INS-examine-Hyperinsulinism', 'Atherosclerosis-coexpress-TP53', 'Delirium-associated-NEFL', 'NEFL-associated-Delirium', 'Aneurysm-shift-NEFL', 'Muscular Dystrophies-linked-CNBP', 'ATP7A-implicated-Neoplasms', 'CNBP-cause-Movement Disorders', 'HP-present-Cardiovascular Diseases', 'SIRT3-govern-Carcinogenesis', 'Osteoarthritis-reflect-ALB', 'Drug-Related Side Effects and Adverse Reactions-activate-NFE2L2', 'INS-measure-Hyperinsulinism', 'CCL5-found-Cardiovascular Diseases', 'RECQL4-range-Carcinogenesis', 'RECQL-implicated-Breast Neoplasms', 'RECQL-expressed-Neoplasms', 'Pulmonary Disease, Chronic Obstructive-treated-FOXO3', 'Werner Syndrome-observed-WRN', 'SPP1-associated-Hypertension', 'Hypertension-associated-SPP1', 'SPP1-measure-Hypertension', 'Obesity-precede-INS', 'KL-indicate-Neoplasms', 'MAPT-cause-Nerve Degeneration', 'INS-evaluate-Hypothalamic Neoplasms', 'Drug-Related Side Effects and Adverse Reactions-undergo-MAPT', 'IGF1-lead-Fractures, Bone', 'Thyroid Neoplasms-investigated-CHGA', 'CDK9-represent-Leukemia, Myeloid, Acute', 'CDK9-recruit-Leukemia, Myeloid, Acute', 'TFF2-suffer-Headache Disorders, Secondary', 'PRKAA1-sustain-Protein-Energy Malnutrition', 'CX3CR1-bind-Infections', 'SHBG-considered-Metabolic Syndrome', 'MTOR-involved-Endometrial Hyperplasia', 'ELN-produce-Vascular System Injuries', 'FMR1-reduce-Aneuploidy', 'METRNL-associated-Weight Loss', 'Weight Loss-associated-METRNL', 'HDAC2-implicated-Neurodegenerative Diseases', 'HDAC2-reduce-Neurotoxicity Syndromes', 'PTH-increase-Fractures, Bone', 'MAPT-protect-Alzheimer Disease', 'SIRT1-result-Prostatic Neoplasms', 'SIRT1-develop-Prostatic Neoplasms', 'PTH-reported-Heart Failure', 'INS-related-Hemostatic Disorders', 'PPIA-promote-Infections', 'PPIA-play-Infections', 'PPIA-inhibit-Infections', 'HSPB8-play-Wounds and Injuries', 'Inflammation-fail-CRP', 'HSPB8-facilitate-Heart Diseases', 'SNCA-linked-Parkinson Disease', 'Alzheimer Disease-associated-FYN', 'FYN-associated-Alzheimer Disease', 'FYN-reflect-Alzheimer Disease', 'VDR-identify-Autoimmune Diseases', 'INS-associated-Osteoarthritis', 'Osteoarthritis-associated-INS', 'TRAF3-prevent-Bone Neoplasms', 'INS-play-Prostatic Neoplasms', 'MMP1-result-Xeroderma Pigmentosum', 'EPO-induce-Heart Arrest', 'TCN2-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-TCN2', 'SIRT1-shown-Non-alcoholic Fatty Liver Disease', 'Prostatic Neoplasms-develop-KLK3', 'MAPT-enhance-Alzheimer Disease', 'KLK3-explained-Prostatic Neoplasms', 'POMC-indicate-Cushing Syndrome', 'CLU-cause-Neoplasms', 'PRRT2-analyzed-Alzheimer Disease', 'PRRT2-examine-Alzheimer Disease', 'Melkersson-Rosenthal Syndrome-genotyped-APOE', 'MYC-expand-Diabetes Mellitus', 'FANCD2-play-Fanconi Anemia', 'INHBE-aid-Neoplasms', 'INHBE-act-Neoplasms', 'INHBE-known-Inflammation', 'CRP-compare-Tuberculosis, Lymph Node', 'Insulin Resistance-decrease-SESN3', 'ERCC2-contribute-Genetic Diseases, Inborn', 'MAPT-develop-Tauopathies', 'BDNF-implicated-Communicable Diseases', 'TTR-ameliorate-Amyloidosis', 'TTR-termed-Amyloidosis', 'INS-develop-Diabetes, Gestational', 'APOE-factors-Alzheimer Disease', 'GLO1-associated-Inflammation', 'Inflammation-associated-GLO1', 'NOS2-incubated-Alzheimer Disease', 'GFAP-shown-Gliosis', 'GFAP-involved-Gliosis', 'INS-associated-Atrial Fibrillation', 'Atrial Fibrillation-associated-INS', 'Pleural Effusion-show-CD79A', 'SLC5A2-reduce-Heart Failure', 'ALB-monitor-Delirium', 'INS-malfunction-Alzheimer Disease', 'GSTM1-play-Neoplasms', 'Hypothalamic Neoplasms-hybridized-POMC', 'POMC-exist-Hypothalamic Neoplasms', 'Neoplasms-treat-NPEPPS', 'Werner Syndrome-manifest-WRN', 'BDNF-cause-Dementia', 'CLU-endowed-Death', 'SIRT6-associated-Coronary Artery Disease', 'Coronary Artery Disease-associated-SIRT6', 'SIRT6-play-Coronary Artery Disease', 'Infections-cause-CD4', 'Alzheimer Disease-investigate-BACE1', 'Alzheimer Disease-promoted-TTR', 'NEFL-display-Sarcopenia', 'MAPK8-play-Hearing Disorders', 'Obesity-caused-LEP', 'Alzheimer Disease-treat-EIF2AK2', 'EIF2AK2-decrease-Alzheimer Disease', 'Neurodegenerative Diseases-take-LTF', 'ABCG2-observed-Hyperuricemia', 'Neoplasms-quantify-GHRH', 'Cardiovascular Diseases-associated-CDKN2A', 'CDKN2A-associated-Cardiovascular Diseases', 'CYP19A1-termed-Ovarian Diseases', 'WWP1-regulate-Ventricular Remodeling', 'DRD4-considered-Parkinson Disease', 'NEBL-express-Osteosarcoma', 'SLC22A4-predisposed-Inflammation', 'PRL-affect-Chiari-Frommel Syndrome', 'CERS2-indicated-Neoplasms', 'Meningeal Neoplasms-analyzed-CERS2', 'CERS2-downregulated-Meningeal Neoplasms', 'CERS2-correlated-Neoplasms', 'CERS2-identify-Meningeal Neoplasms', 'HDAC4-shown-Hypertrophy', 'NPM1-associated-Neoplasms', 'Neoplasms-associated-NPM1', 'JAK2-associated-Neoplasms', 'Neoplasms-associated-JAK2', 'Neoplasms-suspect-NPM1', 'STAT5B-correlated-Neoplasms', 'Obesity, Abdominal-associated-BGLAP', 'BGLAP-associated-Obesity, Abdominal', 'SIRT1-linked-Inflammation', 'Inflammation-involved-CRP', 'Pain-increase-GGH', 'ALB-indicate-Malnutrition', 'SIRT1-decrease-Venous Thrombosis', 'APOE-estimate-Stroke', 'APOE-develop-Stroke', 'Venous Thrombosis-associated-SIRT1', 'SIRT1-associated-Venous Thrombosis', 'SIRT1-reduce-Venous Thrombosis', 'Alzheimer Disease-constitute-TTR', 'TTR-inhibit-Drug-Related Side Effects and Adverse Reactions', 'TTR-measure-Alzheimer Disease', 'Chest Pain-found-IGFBP1', 'Neoplasms-exhibit-SIRT3', 'SIRT3-identify-Neoplasm Recurrence, Local', 'SPP1-associated-Osteoarthritis', 'Osteoarthritis-associated-SPP1', 'PON1-display-Death', 'Osteoarthritis-play-SPP1', 'Osteoarthritis-related-SPP1', 'Osteoarthritis-use-SPP1', 'IL6-include-Atherosclerosis', 'AMIGO1-identify-Alzheimer Disease', 'SHH-suppress-Erectile Dysfunction', 'Cardiomyopathy, Dilated-involved-NAMPT', 'NDUFB3-develop-Alzheimer Disease', 'SPRY1-cause-Sleep Initiation and Maintenance Disorders', 'SLC25A6-down-regulated-Neoplasms', 'PRKAA2-block-Metabolic Syndrome', 'UQCRC1-methylated-Alzheimer Disease', 'Psychoses, Substance-Induced-include-NTS', 'INS-quantify-Dementia', 'Weight Loss-follow-IL6', 'Diabetes Mellitus-undertake-INS', 'Infections-infect-CXCL10', 'Hypertension-found-CP', 'PARP1-involved-Inflammation', 'FOXO3-implicated-Osteoarthritis', 'FOXO3-explore-Osteoarthritis', 'ATM-targeted-Microsatellite Instability', 'ATM-report-Stomach Neoplasms', 'Stomach Neoplasms-studied-ATM', 'CCL11-investigate-Sarcopenia', 'Osteogenesis Imperfecta-related-MAPK8', 'RUFY3-associated-Neoplasms', 'Neoplasms-associated-RUFY3', 'RUFY3-evaluate-Neoplasms', 'RUFY3-associated-Breast Neoplasms', 'Breast Neoplasms-associated-RUFY3', 'Diabetes Mellitus-treated-ADIPOQ', 'NINJ2-show-Mandibular Nerve Injuries', 'Hypotension-reduced-REN', 'NOS3-associated-Glaucoma', 'Glaucoma-associated-NOS3', 'CRP-associated-Aortic Diseases', 'Aortic Diseases-associated-CRP', 'RGS2-show-Alzheimer Disease', 'SIRT1-point-Neoplasms', 'RGS2-suggested-Alzheimer Disease', 'TP53-predispose-Hematologic Neoplasms', 'XRCC4-show-Arthritis, Rheumatoid', 'FUS-drive-Neoplasms', 'Progeria-activate-LMNA', 'ODC1-expressed-Ovarian Neoplasms', 'CRP-give-Appendicitis', 'TP53INP1-accelerate-Pancreatic Diseases', 'Ovarian Neoplasms-produce-ODC1', 'TP53INP1-contribute-Pancreatic Neoplasms', 'Nervous System Diseases-associated-SETX', 'SETX-associated-Nervous System Diseases', 'NFE2L2-provide-Neoplasms', 'RBFOX1-involved-Alzheimer Disease', 'NFE2L2-approved-Multiple Sclerosis', 'Hypothyroidism-related-TPO', 'Tauopathies-characterized-MAPT', 'SNCB-function-Neurodegenerative Diseases', 'Alzheimer Disease-targeted-ACHE', 'ACHE-defined-Alzheimer Disease', 'ACHE-use-Alzheimer Disease', 'CLEC12A-show-Leukemia, Myeloid, Acute', 'Leukemia, Myeloid, Acute-overexpress-FLT3', 'WRN-lack-Werner Syndrome', 'Obesity-exhibit-CRP', 'PGAM5-associated-Infertility, Female', 'Infertility, Female-associated-PGAM5', 'PGAM5-associated-Ovarian Diseases', 'Ovarian Diseases-associated-PGAM5', 'Neoplasms-exhibit-CRP', 'Alzheimer Disease-matched-APOE', 'RPTOR-compare-Breast Neoplasms', 'APOE-assess-Death', 'SST-described-Alzheimer Disease', 'SST-play-Alzheimer Disease', 'CST3-detect-Kidney Diseases', 'VEGFA-associated-Alzheimer Disease', 'Alzheimer Disease-associated-VEGFA', 'VEGFA-relate-Neurodegenerative Diseases', 'MAPT-induced-Diabetes Mellitus', 'Kidney Diseases-associated-LYZ', 'LYZ-associated-Kidney Diseases', 'CD4-tend-Melanoma', 'CD4-increased-Melanoma', 'CD4-decreased-Melanoma', 'FOXP3-increased-Melanoma', 'DRD2-use-Memory Disorders', 'IL6-associated-Breast Neoplasms', 'Breast Neoplasms-associated-IL6', 'Ovarian Diseases-show-PAEP', 'VEGFA-induced-Hypoxia', 'ANXA5-correlate-Aneurysm', 'GBA-associated-Death', 'Death-associated-GBA', 'KL-involved-Psychoses, Substance-Induced', 'Tauopathies-enhance-MAPT', 'Tauopathies-exist-MAPT', 'Tauopathies-exacerbated-MAPT', 'GNRH1-mediated-Nerve Degeneration', 'GNRH1-converge-Nerve Degeneration', 'CTSK-involve-Osteoarthritis', 'CTSK-use-Cartilage Diseases', 'CST3-reveal-Lupus Erythematosus, Systemic', 'MAPT-cleared-Plaque, Amyloid', 'Growth Disorders-document-POLD1', 'POLD1-diagnosed-Werner Syndrome', 'LMNA-found-Werner Syndrome', 'POLD1-describe-Hearing Loss', 'Neoplasms-inactivated-FOXO3', 'COL11A2-associated-Alzheimer Disease', 'Alzheimer Disease-associated-COL11A2', 'KLF2-downregulated-Osteoarthritis', 'MMP13-caused-Osteoarthritis', 'Alzheimer Disease-reduce-LRP2', 'NGF-stimulate-Wounds and Injuries', 'INS-result-Hypoglycemia', 'Death-exist-ACE', 'ELN-increase-Vascular Calcification', 'INS-appear-Stroke', 'GDF11-protect-Coronary Artery Disease', 'Alzheimer Disease-associated-RELN', 'RELN-associated-Alzheimer Disease', 'RELN-implicated-Alzheimer Disease', 'BMP2-play-Calcinosis', 'Neoplasms-carry-TP53', 'TSLP-play-Drug Hypersensitivity', 'Drug Hypersensitivity-exacerbated-TSLP', 'AMH-validate-Ovarian Diseases', 'MACF1-associated-Parkinson Disease', 'Parkinson Disease-associated-MACF1', 'MACF1-result-Parkinson Disease', 'Infections-develop-TNF', 'ALPP-elevated-Osteoporosis', 'SDHC-associated-Neoplasms', 'Neoplasms-associated-SDHC', 'LRP5-upregulated-Cartilage Diseases', 'Cardiovascular Diseases-predict-IL6', 'TG-influenced-Thyroid Diseases', 'Alzheimer Disease-spread-MAPT', 'VEGFA-exacerbate-Spinal Cord Injuries', 'CD5-carry-Leukemia, Lymphocytic, Chronic, B-Cell', 'Prostatic Neoplasms-treated-GNRH1', 'Obesity-inhibited-LEP', 'Hypercholesterolemia-exist-INS', 'NAT10-expressed-Neoplasms', 'NAT10-result-Growth Disorders', 'TP53-exert-Neoplasms', 'SPP1-compared-Asthma', 'SPP1-associated-Inflammation', 'Inflammation-associated-SPP1', 'DDIT4-measure-Osteoarthritis', 'Heart Failure-caused-NOS3', 'TNFSF11-associated-Osteolysis', 'Osteolysis-associated-TNFSF11', 'CERS5-implicated-Neoplasms', 'OXT-associated-Death', 'Death-associated-OXT', 'Alzheimer Disease-interact-APOE', 'Death-attenuate-APOE', 'APOE-identify-Alzheimer Disease', 'CAT-decreased-Dementia', 'CAT-measured-Brain Diseases', 'CXCL10-associated-Death', 'Death-associated-CXCL10', 'Infections-promote-TSLP', 'Hypotension-stimulate-INS', 'TSLP-reduce-Pneumonia', 'INS-enhanced-Obesity', 'Progeria-characterized-LMNA', 'SH2B3-involved-Inflammation', 'CRTC1-reverse-Memory Disorders', 'ACE-preferred-Heart Failure', 'Muscular Dystrophy, Duchenne-permit-DMD', 'Muscular Dystrophy, Duchenne-produced-DMD', 'AMH-inhibit-Pulmonary Atresia', 'PRKAB1-activate-Breast Neoplasms', 'Death-remain-ACE', 'ATG7-cause-Neurodegenerative Diseases', 'ATG7-define-Heredodegenerative Disorders, Nervous System', 'SERPINE1-reflect-Atherosclerosis', 'SEPSECS-associated-Atrophy', 'Atrophy-associated-SEPSECS', 'SLPI-provide-Pneumonia', 'CRP-occur-Death', 'ALB-associated-Kidney Failure, Chronic', 'Kidney Failure, Chronic-associated-ALB', 'Hypoxia-enhance-VEGFA', 'CRP-related-Fractures, Bone', 'SIRT1-upregulated-Colorectal Neoplasms', 'MME-measure-Hypertension', 'INS-considered-Hypoglycemia', 'Carcinoma, Hepatocellular-modulate-BMP4', 'Venous Thromboembolism-discriminated-GAS6', 'GAS6-measure-Venous Thromboembolism', 'GAS6-measured-Venous Thromboembolism', 'MAPT-examine-Alzheimer Disease', 'PIK3R2-used-Death', 'PIK3R2-determine-Death', 'Diabetes Mellitus-elevate-MFN2', 'PON1-suggested-Cardiovascular Diseases', 'Infections-induce-SIRT1', 'SIRT1-implicated-Inflammation', 'SPP1-increased-Non-alcoholic Fatty Liver Disease', 'MME-show-Periodontal Diseases', 'HACE1-implicate-Huntington Disease', 'DKK3-function-Neoplasms', 'Heart Arrest-induced-SMAD3', 'MAPT-observed-Neurodegenerative Diseases', 'GAST-change-Ulcer', 'Melanoma-carry-BRAF', 'Sarcopenia-associated-CCN1', 'CCN1-associated-Sarcopenia', 'CCN1-activate-Heart Arrest', 'IL10-associated-Infarction', 'Infarction-associated-IL10', 'INS-prescribed-Diabetes Mellitus', 'CNTF-underexpressed-Genetic Diseases, Inborn', 'Diabetes Mellitus-associated-FGF21', 'FGF21-associated-Diabetes Mellitus', 'Insulin Resistance-correlated-FGF21', 'CYP2D6-protect-Neoplasms', 'MTOR-underlie-Neurodegenerative Diseases', 'MTOR-investigated-Alzheimer Disease', 'ACE2-implicate-Cardiovascular Diseases', 'DYNLT3-play-Breast Neoplasms', 'ACE2-compare-Hypertension', 'ACE2-measured-Hypertension', 'ACE2-found-Hypertension', 'Atherosclerosis-regard-PCSK9', 'APOE-occur-Alzheimer Disease', 'BDNF-treat-Neurodegenerative Diseases', 'NR3C2-assess-Hypothalamic Neoplasms', 'FZD5-delay-Heart Arrest', 'Shock-redistribute-VIM', 'Diabetes Mellitus, Type 2-result-TNFRSF11B', 'LEPR-show-Osteoarthritis', 'Diabetes Mellitus, Type 1-use-INS', 'Neuroblastoma-fused-FOXR1', 'Sleep Apnea, Obstructive-upregulate-MAPT', 'PPIP5K2-show-Death', 'Diabetes Mellitus-mediate-ADIPOQ', 'REN-evaluated-Hypertension', 'Death-increased-CD4', 'Ovarian Neoplasms-derived-PSEN1', 'PSEN1-used-Ovarian Neoplasms', 'PSEN1-evaluate-Ovarian Neoplasms', 'AMH-remain-Polycystic Ovary Syndrome', 'Polycystic Ovary Syndrome-present-AMH', 'NCOR2-cause-Metabolic Diseases', 'Ovarian Diseases-demonstrate-AMH', 'Ovarian Diseases-observed-AMH', 'Polycystic Ovary Syndrome-demonstrate-AMH', 'GH1-approve-Growth Disorders', 'INS-deprive-Hyperinsulinism', 'SIRT1-accelerate-Endometrial Neoplasms', 'SIRT1-accelerate-Neoplasms', 'FNDC5-prompt-Aneurysm', 'FNDC5-played-Aneurysm', 'LMNB1-correlate-Neoplasms', 'LMNB1-upregulated-Carcinoma, Hepatocellular', 'INS-reduce-Hypoglycemia', 'INS-involve-Hyperemia', 'INS-induced-Hyperemia', 'Dystonia-pretreated-RAPGEF1', 'Progeria-treat-MTOR', 'SIRT1-lead-Neurologic Manifestations', 'GH1-develop-Seizures', 'GH1-improve-Death', 'INS-precede-Hyperinsulinism', 'MYBL2-sourced-Coronary Artery Disease', 'APOE-differ-Alzheimer Disease', 'NSMCE2-present-Bloom Syndrome', 'Hyponatremia-implicate-AVP', 'NFKB1-protect-Ischemia', 'CRP-live-Pain', 'Chronic Pain-observed-CRP', 'Osteoporosis-caused-PLS3', 'FGF23-increased-Renal Insufficiency, Chronic', 'KL-represent-Renal Insufficiency, Chronic', 'CISD2-ameliorate-Heart Diseases', 'Rothmund-Thomson Syndrome-carry-RECQL4', 'Sleep Apnea, Obstructive-test-CRP', 'ATM-exacerbated-Mitochondrial Diseases', 'Hypoglycemia-link-INS', 'ACE-use-Hypertension', 'Hyperglycemia-improve-INS', 'Mitochondrial Diseases-underlie-INS', 'ACHE-result-Drug-Related Side Effects and Adverse Reactions', 'ACHE-open-Alzheimer Disease', 'APOE-associated-Aneurysm', 'Aneurysm-associated-APOE', 'FOXO3-activated-Neoplasms', 'XRCC3-investigated-Myocardial Infarction', 'IFNA1-recommend-Hepatitis C, Chronic', 'BCL2-result-Death', 'PNMA2-disclose-Lung Neoplasms', 'CETP-excluded-Aortic Aneurysm, Abdominal', 'ATG16L1-inhibit-Neoplasms', 'EPO-compare-Anemia, Iron-Deficiency', 'AGER-prevent-Diabetic Angiopathies', 'EZH2-accelerate-Osteogenesis Imperfecta', 'BGLAP-expressed-Cataract', 'Adenoviridae Infections-introduced-PPARG', 'FGF23-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-FGF23', 'NLRP3-involved-Liver Neoplasms', 'NLRP3-used-Liver Neoplasms', 'NLRP3-improve-Liver Neoplasms', 'ACE-investigated-Cardiovascular Diseases', 'ACE-report-Osteoarthritis', 'ACE-investigate-Osteoarthritis', 'FGF23-involved-Cardiovascular Diseases', 'ATM-induce-Inflammation', 'ELN-form-Colonic Neoplasms', 'KL-render-Renal Insufficiency, Chronic', 'KL-identified-Renal Insufficiency, Chronic', 'Alzheimer Disease-derived-PZP', 'Neoplasms-harbor-SIRT3', 'SIRT3-sensitize-Neoplasms', 'SIRT6-interfere-Neoplasms', 'SIRT6-appear-Neoplasms', 'TTR-provide-Blood Platelet Disorders', 'Alzheimer Disease-discuss-TTR', 'TTR-help-Alzheimer Disease', 'Sepsis-produced-THPO', 'THPO-decreased-Hepatic Veno-Occlusive Disease', 'Death-induce-ANXA5', 'Hepatic Veno-Occlusive Disease-prevent-THPO', 'MAPT-related-Parkinson Disease', 'Death-assessed-ANXA5', 'CRP-determine-Anemia', 'PNPT1-implicated-Inflammation', 'KL-protect-Cardiovascular Diseases', 'KL-represent-Neurologic Manifestations', 'ACE-continue-Death', 'ACE-combined-Death', 'TSHR-linked-Neoplasms', 'KL-assessed-Pulmonary Disease, Chronic Obstructive', 'COMT-associated-Delirium', 'Delirium-associated-COMT', 'Alzheimer Disease-observed-GFAP', 'Alzheimer Disease-express-CALB2', 'KL-reduced-Pulmonary Disease, Chronic Obstructive', 'ACHE-account-Drug-Related Side Effects and Adverse Reactions', 'ZMPSTE24-improve-Progeria', 'Neoplasms-include-MTOR', 'Neoplasms-reducingthe-DDR2', 'Dementia-increased-CST3', 'CST3-associated-Dementia', 'Dementia-associated-CST3', 'Muscular Atrophy-induce-AKT1', 'GLB1-play-Lysosomal Storage Diseases', 'PPARG-promote-Osteogenesis Imperfecta', 'Metabolic Diseases-paralleled-NLRP3', 'CTSB-predict-Cardiovascular Diseases', 'CDK5-associated-Neurodegenerative Diseases', 'Neurodegenerative Diseases-associated-CDK5', 'ABCC6-result-Calcinosis', 'SIRT1-promote-Skin Neoplasms', 'SIRT1-associate-Metabolic Diseases', 'Metabolic Diseases-associate-SIRT1', 'GLO1-diminished-Alzheimer Disease', 'GLO1-reduce-Alzheimer Disease', 'GLO1-show-Alzheimer Disease', 'GLO1-increased-Alzheimer Disease', 'GLO1-prevail-Alzheimer Disease', 'PTH-associated-Cardiomyopathy, Hypertrophic', 'Cardiomyopathy, Hypertrophic-associated-PTH', 'Cough-develop-ACE', 'ACE-administered-Ventricular Dysfunction, Left', 'Glioblastoma-distinguished-TP53', 'SELL-interpreted-Inflammation', 'INS-observed-Primary Ovarian Insufficiency', 'Neurodegenerative Diseases-mediated-MAPT', 'DIAPH2-associated-Primary Ovarian Insufficiency', 'Primary Ovarian Insufficiency-associated-DIAPH2', 'Hip Fractures-measure-BGLAP', 'BGLAP-remain-Fractures, Bone', 'Prader-Willi Syndrome-associated-MAPT', 'MAPT-associated-Prader-Willi Syndrome', 'NCOA5-involved-Neoplasms', 'CST3-contribute-Glycogen Storage Disease Type II', 'INS-prevent-Death', 'INS-investigate-Neurotoxicity Syndromes', 'MAPT-down-regulate-Neurotoxicity Syndromes', 'FGF21-associated-Death', 'Death-associated-FGF21', 'CDC42-associated-Obesity', 'Obesity-associated-CDC42', 'Diabetes Mellitus-influence-SIRT1', 'EPO-stabilize-Anemia', 'AGER-give-Diabetic Nephropathies', 'Death-calculated-ALB', 'Pulmonary Fibrosis-induced-IGF1', 'Hyperparathyroidism-estimated-PTH', 'IDH1-implicate-Communicable Diseases', 'Pulmonary Heart Disease-ameliorate-CDKN2A', 'Progeria-display-RAN', 'RAN-correct-Progeria', 'ESR1-contribute-Atherosclerosis', 'Progeria-review-LMNB1', 'SIRT3-protect-Death', 'CALR-bind-Neoplasms', 'ALPP-linked-Disorders of Sex Development', 'Anemia-estimate-CYGB', 'SIRT1-down-regulated-Heart Failure', 'MANF-alleviate-Liver Failure', 'Osteoarthritis-correlated-TGFBR1', 'ACVRL1-contribute-Osteoarthritis', 'IL18-contribute-Alzheimer Disease', 'IAPP-deregulate-Mitochondrial Diseases', 'Alzheimer Disease-observed-APOE', 'WRN-play-Heart Arrest', 'Werner Syndrome-revealed-WRN', 'ELN-seem-Aneurysm', 'KNDC1-promote-Heart Arrest', 'Vision Disorders-show-PRL', 'LEP-enhance-Disorders of Sex Development', 'Metabolic Syndrome-mediate-INS', 'PON1-implicated-Atherosclerosis', 'BACE1-implicated-Alzheimer Disease', 'Sarcopenia-target-AR', 'Neurodegenerative Diseases-arise-WDR45', 'SHBG-measured-Diabetes Mellitus', 'BDNF-involved-Alzheimer Disease', 'BACE1-evaluated-Alzheimer Disease', 'INS-proposed-Diabetes Mellitus, Type 2', 'Diabetes Mellitus-follow-INS', 'KL-document-Renal Insufficiency, Chronic', 'GDF15-inhibit-Hypertrophy', 'CHAT-correlate-Dementia', 'APOE-modulate-Alzheimer Disease', 'Neoplasms-mutated-BRAF', 'PPARG-modulate-Alzheimer Disease', 'PPARG-associated-Alzheimer Disease', 'Alzheimer Disease-associated-PPARG', 'LRRK2-distinguished-Parkinson Disease', 'BPIFB4-detected-Carotid Stenosis', 'LRRK2-compare-Parkinson Disease', 'LRRK2-defined-Parkinson Disease', 'Parkinson Disease-inherit-LRRK2', 'BDNF-secreted-Hypothalamic Neoplasms', 'WWOX-identify-Sclerosis', 'SIRT1-involved-Kidney Diseases', 'PTH-remain-Death', 'PTH-considered-Osteoporosis', 'MAPT-disrupted-Alzheimer Disease', 'KL-play-Colorectal Neoplasms', 'Aneurysm-dilate-ELN', 'MSTN-associated-Seizures', 'Seizures-associated-MSTN', 'VEGFA-detected-Macular Degeneration', 'NEFL-differentiate-Alzheimer Disease', 'KLK3-determine-Prostatic Neoplasms', 'Prostatic Neoplasms-compare-KLK3', 'USP18-decrease-Inflammation', 'KLK3-predict-Neoplasms', 'KLK3-remain-Prostatic Neoplasms', 'Intracranial Arteriosclerosis-regulate-CNOT3', 'VDR-associated-Diabetic Nephropathies', 'Diabetic Nephropathies-associated-VDR', 'DAXX-associated-Breast Neoplasms', 'Breast Neoplasms-associated-DAXX', 'IL6-elevated-Diabetes Mellitus', 'ADIPOQ-compare-Obesity', 'SIRT3-downregulated-Neurodegenerative Diseases', 'SIRT3-contribute-Parkinson Disease', 'MME-approved-Heart Failure', 'KL-play-Inflammation', 'Muscular Dystrophies-express-IGF1', 'VWF-accompanied-Hemorrhage', 'LEP-associated-Glycogen Storage Disease Type II', 'Glycogen Storage Disease Type II-associated-LEP', 'Pulmonary Disease, Chronic Obstructive-study-GH1', 'Sleep Deprivation-associated-MAOB', 'MAOB-associated-Sleep Deprivation', 'GJA1-increased-Ischemia', 'Fractures, Bone-decrease-MAPK8', 'MAPK9-involved-Ventricular Remodeling', 'SORL1-act-Alzheimer Disease', 'IGF1-contribute-Cardiomyopathy, Dilated', 'Pulmonary Disease, Chronic Obstructive-identify-SERPINE2', 'PRRX1-show-Atrial Fibrillation', 'Seizures-predict-GH1', 'MAPT-implicated-Alzheimer Disease', 'INS-defined-Hypotension', 'SIRT1-detected-Acquired Immunodeficiency Syndrome', 'SIRT1-induced-Carcinoma, Hepatocellular', 'GH1-prove-Obesity, Abdominal', 'UBQLNL-associated-Neoplasms', 'Neoplasms-associated-UBQLNL', 'MME-result-Alzheimer Disease', 'MME-used-Alzheimer Disease', 'PHEX-mutated-Familial Hypophosphatemic Rickets', 'Infections-induce-HMGB1', 'HMGB1-implicated-Inflammation', 'HMGB1-promote-Inflammation', 'HMGB1-released-Infections', 'Cystic Fibrosis-address-CFTR', 'ERCC6-mutated-Cockayne Syndrome', 'PER2-result-Prostatic Neoplasms', 'MFSD2A-investigate-Alzheimer Disease', 'MFSD2A-analyzed-Alzheimer Disease', 'MAPT-constitute-Mitochondrial Diseases', 'YAP1-evaluate-Breast Neoplasms', 'FNDC5-correlate-Bone Diseases, Metabolic', 'FNDC5-associated-Osteoporosis', 'Osteoporosis-associated-FNDC5', 'FNDC5-find-Bone Diseases, Metabolic', 'TSG101-released-Prostatic Neoplasms', 'KLK3-accord-Prostatic Neoplasms', 'NCOA3-overexpressed-Neoplasms', 'Neoplasms-inhibited-NCOA3', 'Dementia-correlate-MAPT', 'Parkinson Disease-use-GBA', 'Atrophy-decrease-GRIA1', 'ADIPOQ-correlate-Heart Failure', 'IRS1-assessed-Alzheimer Disease', 'TERF1-compare-Osteoporotic Fractures', 'TERF1-use-Osteoporotic Fractures', 'SIRT1-modify-Obesity', 'MTHFR-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-MTHFR', 'Sarcopenia-exhibit-GH1', 'ALB-assessed-Sarcopenia', 'SIRT1-modify-Inflammation', 'Weight Loss-decrease-INS', 'APOE-explore-Neurodegenerative Diseases', 'APOE-contribute-Neurodegenerative Diseases', 'Inflammation-suggested-CRP', 'WRNIP1-interact-Werner Syndrome', 'CRP-predict-Appendicitis', 'CRP-elevated-Appendicitis', 'CP-noted-Neoplasms', 'CP-found-Hyperplasia', 'Osteosarcoma-evaluate-FOXO1', 'Hypothalamic Diseases-engendered-LEP', 'KL-induced-Leukoencephalopathies', 'HIV Infections-associated-CD8A', 'CD8A-associated-HIV Infections', 'KL-participate-Neoplasms', 'ESR1-connect-Diabetes Mellitus', 'KL-mediated-Neoplasms', 'ACSL4-alter-Infarction, Middle Cerebral Artery', 'BDNF-correlate-Urinary Incontinence, Stress', 'INS-act-Diabetes Mellitus, Type 2', 'NFE2L2-activate-Drug-Related Side Effects and Adverse Reactions', 'NAMPT-restore-Heredodegenerative Disorders, Nervous System', 'ESR1-associated-Alzheimer Disease', 'Alzheimer Disease-associated-ESR1', 'RNASE3-compared-Asthma', 'BNIP3-link-Inflammation', 'PI4K2A-define-Metabolic Diseases', 'KL-decreased-Adenoma, Villous', 'GH1-arise-Growth Hormone-Secreting Pituitary Adenoma', 'Neoplasms-repressed-SIRT1', 'CCL2-orchestrate-Neoplasms', 'PCNA-increase-Diabetes Mellitus', 'PTX3-involved-Breast Neoplasms', 'AR-delay-Alzheimer Disease', 'Multiple Sclerosis-express-KCNJ10', 'TP53-prevent-Neoplasms', 'INS-persist-Hyperglycemia', 'MAPT-focus-Alzheimer Disease', 'DLG4-treat-Nervous System Diseases', 'KL-promote-Demyelinating Diseases', 'CD4-become-Atherosclerosis', 'INS-demonstrated-Diabetes Mellitus', 'INS-increase-Fractures, Bone', 'NF1-shown-Osteoporosis', 'Alzheimer Disease-code-APOE', 'PRRT2-analyzed-Hypotension', 'S100A8-associated-Inflammation', 'Inflammation-associated-S100A8', 'NGF-increased-Alzheimer Disease', 'TP53-induce-Neoplasms', 'CXCR4-nullify-Alzheimer Disease', 'CD4-met-AIDS Arteritis, Central Nervous System', 'IL22-decrease-Dermatitis, Atopic', 'Dermatitis, Atopic-mimic-NELFCD', 'PTH-dialysed-Hypertension', 'INS-requiring-Diabetes Mellitus', 'INS-exclude-Diabetes Mellitus', 'NFE2L2-upregulate-Inflammation', 'Acute Kidney Injury-shown-CDKN2AIP', 'CDKN2AIP-cause-Aneuploidy', 'CDKN2AIP-regulate-Neoplasms', 'CLU-associate-Plaque, Amyloid', 'Plaque, Amyloid-associate-CLU', 'Facial Dermatoses-reveal-CLU', 'PTH-live-Bone Diseases, Metabolic', 'PTH-found-Hypercalcemia', 'INS-demand-Polycystic Ovary Syndrome', 'Retinoblastoma-involved-GCG', 'IGF1-accompany-Cardiovascular Diseases', 'TARDBP-characterized-Torsades de Pointes', 'SLC6A3-induce-Parkinson Disease, Secondary', 'Neoplasms-count-CDKN2A', 'ALB-evaluated-Prostatic Hyperplasia', 'IL17A-involved-Chronic Disease', 'IL17A-mediate-Inflammation', 'PKM-contribute-Retinal Neovascularization', 'MTHFR-associated-Hyperhomocysteinemia', 'Hyperhomocysteinemia-associated-MTHFR', 'CDK6-associated-Heart Arrest', 'Heart Arrest-associated-CDK6', 'CDK6-result-Heart Arrest', 'INS-assessed-Non-alcoholic Fatty Liver Disease', 'SOST-demonstrated-Renal Insufficiency, Chronic', 'DNMT3A-increased-Osteoarthritis', 'KL-increase-Inflammation', 'KL-reduce-Pulmonary Disease, Chronic Obstructive', 'Necrosis-decrease-KL', 'Delirium-compared-ALB', 'ACHE-protect-Drug-Related Side Effects and Adverse Reactions', 'MAPT-account-Memory Disorders', 'GCG-evolve-Sarcopenia', 'Sarcopenia-feature-INS', 'Nervous System Diseases-associated-MAPT', 'MAPT-associated-Nervous System Diseases', 'INS-mediate-Sarcopenia', 'BDNF-impact-Alzheimer Disease', 'CD4-used-HIV Infections', 'KLK6-develop-Alzheimer Disease', 'TNF-play-Insulin Resistance', 'Macular Degeneration-caused-ABCA4', 'GCG-compromise-Hypoglycemia', 'XRCC1-genotyped-Neoplasms', 'SEMA3A-result-Osteoporotic Fractures', 'SEMA3A-ameliorate-Bone Neoplasms', 'VIP-use-Lung Neoplasms', 'VIP-inhibit-Carcinoma, Non-Small-Cell Lung', 'Lung Neoplasms-regulated-VIP', 'VIP-detected-Carcinoma, Non-Small-Cell Lung', 'FOXO1-exhibit-Infections', 'CRP-increase-Metabolic Syndrome', 'ALB-associated-Dementia', 'Dementia-associated-ALB', 'PRKCA-show-Death', 'Infections-evaluate-CRP', 'CD8A-compare-Hirschsprung Disease', 'IL17A-prevented-Retinal Degeneration', 'IL17A-play-Retinal Degeneration', 'LRRK2-calculated-Parkinson Disease', 'LRRK2-affected-Parkinson Disease', 'LRRK2-seem-Parkinson Disease', 'PRL-studied-Chiari-Frommel Syndrome', 'ELN-known-Facial Dermatoses', 'LRRK2-increase-Nerve Degeneration', 'Prostatic Neoplasms-overexpress-GPHA2', 'GGH-increase-Dwarfism, Pituitary', 'Dental Caries-associated-ALB', 'ALB-associated-Dental Caries', 'Heart Diseases-induce-EMD', 'Dyslipidemias-carry-APOE', 'LONP1-implicated-Mitochondrial Diseases', 'ALDH2-occur-Reperfusion Injury', 'ALDH2-known-Liver Diseases, Alcoholic', 'ALDH2-become-Reperfusion Injury', 'IAPP-found-Diabetes Mellitus, Type 2', 'Reperfusion Injury-found-ALDH2', 'IAPP-show-Neurotoxicity Syndromes', 'CD200R1-study-Parkinson Disease', 'CD200R1-induced-Parkinson Disease', 'Neoplasms-accompanied-TNKS', 'Xeroderma Pigmentosum-carry-ERCC4', 'USF3-identify-Osteoporosis', 'BGLAP-determined-Pulmonary Disease, Chronic Obstructive', 'HTT-provide-Huntington Disease', 'Neoplasms-enhance-CD4', 'TGFA-transform-Inflammation', 'Neoplasms-stimulate-IGF2BP2', 'KDM1A-associated-Hypertension', 'Hypertension-associated-KDM1A', 'PCSK9-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-PCSK9', 'Atrial Fibrillation-show-MAP2K4', 'SIRT1-protect-Alzheimer Disease', 'INS-cure-Diabetes Mellitus', 'Atrophy-associated-APOE', 'APOE-associated-Atrophy', 'Hypertrophy-induce-INS', 'INS-secrete-Diabetes Mellitus', 'SIRT1-compare-Alzheimer Disease', 'ESR1-suffer-Infertility, Female', 'Parkinson Disease-require-SUGT1', 'SIRT1-remain-Alzheimer Disease', 'PTH-associated-Fractures, Bone', 'Fractures, Bone-associated-PTH', 'ACE-target-Cardiovascular Diseases', 'Status Epilepticus-affected-CD4', 'AGER-contribute-Aneurysm', 'ATM-mutate-Kidney Diseases', 'CRP-mediate-Obesity', 'Obesity-decompose-CRP', 'Pulmonary Disease, Chronic Obstructive-release-ELANE', 'PGF-mediate-Pulmonary Emphysema', 'PGF-involved-Pulmonary Disease, Chronic Obstructive', 'Alzheimer Disease-found-MAPT', 'INS-exacerbate-Diabetes Mellitus', 'Diabetes Mellitus-associate-GLP1R', 'GLP1R-associate-Diabetes Mellitus', 'SIRT1-prevent-Coronary Artery Disease', 'SIRT1-reduced-Heart Failure', 'SIRT1-use-Heart Failure', 'GSTP1-associated-Prostatic Neoplasms', 'Prostatic Neoplasms-associated-GSTP1', 'Kidney Diseases-measured-CST3', 'Kidney Diseases-considered-CST3', 'CRP-report-Fatigue', 'FOXP1-suppress-Osteosarcoma', 'FOXP1-drive-Osteosarcoma', 'BACE1-considered-Alzheimer Disease', 'SIRT6-promote-Retinal Neovascularization', 'CRP-result-Metabolic Diseases', 'RYR1-occur-Heart Failure', 'CRP-predict-Seizures', 'EGFR-lead-Proteinuria', 'CST3-discriminate-Kidney Diseases', 'CST3-demonstrate-Kidney Diseases', 'CERS2-evaluate-Carcinoma, Hepatocellular', 'CERS2-act-Neoplasms', 'Atherosclerosis-assessed-THBD', 'COX8A-include-Myositis, Inclusion Body', 'MAPT-noted-Nerve Degeneration', 'SHBG-associated-Kyphosis', 'Kyphosis-associated-SHBG', 'Death-calculate-CRP', 'PRNP-increase-Dementia', 'Acute Disease-provoke-GH1', 'KL-measure-Alzheimer Disease', 'ITPR1-characterized-Cerebellar Ataxia', 'CRH-promote-Sleep Wake Disorders', 'CASR-found-Death', 'AR-involved-Prostatic Neoplasms', 'ACHE-used-Alzheimer Disease', 'Obesity-induced-MC4R', 'Retinal Degeneration-exhibit-FMOD', 'INS-alter-Pulmonary Heart Disease', 'TRPC6-improve-Alzheimer Disease', 'TRPC6-changed-Alzheimer Disease', 'Alzheimer Disease-associated-TRPC6', 'TRPC6-associated-Alzheimer Disease', 'TRPC6-reduced-Alzheimer Disease', 'XPC-result-Neoplasms', 'NPPA-associated-Heart Diseases', 'Heart Diseases-associated-NPPA', 'AR-play-Prostatic Neoplasms', 'IFIT1-lost-Infections', 'SLC1A3-shown-Alzheimer Disease', 'TP53-associated-Urinary Bladder Neoplasms', 'Urinary Bladder Neoplasms-associated-TP53', 'Alzheimer Disease-shown-SLC1A3', 'SLC1A3-shown-Dementia', 'Diabetes Mellitus-altered-GAPDH', 'NFE2L2-confer-Breast Neoplasms', 'CYP3A4-result-Rhabdomyolysis', 'APOE-include-Death', 'Death-result-APOE', 'GH1-associated-Acromegaly', 'Acromegaly-associated-GH1', 'ADIPOQ-decreased-Obesity', 'SHBG-associated-Thinness', 'Thinness-associated-SHBG', 'Diabetes Mellitus-combined-INS', 'Diabetes Mellitus-explore-INS', 'Arbovirus Infections-bind-NCL', 'Edema-take-GH1', 'NGF-deliver-Alzheimer Disease', 'FOXO3-protect-Death', 'WRN-carry-Werner Syndrome', 'ARNTL-disrupted-Osteoarthritis', 'CLU-associated-Atrophy', 'Atrophy-associated-CLU', 'Alzheimer Disease-observe-CLU', 'Alzheimer Disease-examine-CLU', 'CLU-reflect-Alzheimer Disease', 'Parkinson Disease-increased-CAT', 'CST3-result-Renal Insufficiency, Chronic', 'AMH-integrated-Polycystic Ovary Syndrome', 'VWF-increased-Myocardial Infarction', 'Neoplasms-show-VIM', 'TNF-recognized-Sepsis', 'MPLKIP-identified-Trichothiodystrophy Syndromes', 'WRN-predispose-Edema', 'SIRT1-shift-Death', 'ODC1-enhance-Necrosis', 'ODC1-diminish-Necrosis', 'KL-predict-Small Cell Lung Carcinoma', 'Neoplasms-labeled-VIM', 'Prostatic Neoplasms-offered-KLK3', 'AGER-induce-Inflammation', 'ADIPOQ-protect-Atherosclerosis', 'KL-protect-Drug-Related Side Effects and Adverse Reactions', 'VEGFA-approved-Retinal Neovascularization', 'CDKN2A-become-Diabetes Mellitus', 'Glucose Intolerance-combine-INS', 'Diabetes Mellitus-determined-INS', 'Metabolic Syndrome-underpinned-INS', 'GDF15-associated-Death', 'Death-associated-GDF15', 'BMP5-upregulated-Prostatic Hyperplasia', 'MST1-cause-Primary Immunodeficiency Diseases', 'CETP-terminated-Death', 'Death-evaluated-CETP', 'APOE-associated-Dyslipidemias', 'Dyslipidemias-associated-APOE', 'INS-increase-Alzheimer Disease', 'Neurotoxicity Syndromes-include-APOE', 'Glucose Intolerance-demonstrate-INS', 'APOE-induced-Brain Injuries', 'Alzheimer Disease-reported-APOE', 'Alzheimer Disease-correlate-APOE', 'APOE-seen-Alzheimer Disease', 'ERCC6-recruited-T-Lymphocytopenia, Idiopathic CD4-Positive', 'Alzheimer Disease-remain-MAPT', 'Cockayne Syndrome-coordinate-ERCC6', 'APOE-diagnosed-Dementia', 'RUBCN-derived-Alzheimer Disease', 'RETN-associated-Heart Failure', 'Heart Failure-associated-RETN', 'Muscular Diseases-report-INS', 'FMR1-underlie-Learning Disabilities', 'SOD2-associated-Carcinoma, Hepatocellular', 'Carcinoma, Hepatocellular-associated-SOD2', 'SOD2-investigate-Carcinoma, Hepatocellular', 'Neoplasms-drive-NTRK1', 'NTRK1-result-Neoplasms', 'NTRK1-drive-Neoplasms', 'PARP1-participate-Inflammation', 'GPNMB-assess-Alzheimer Disease', 'CYP2C19-alter-Pain', 'Neoplasms-contain-PSEN1', 'TBC1D10B-show-Alzheimer Disease', 'XPA-make-Progeria', 'Sarcopenia-contribute-NR3C1', 'Werner Syndrome-suppressed-WRN', 'Neuroblastoma-investigate-MAPT', 'Prostatic Hyperplasia-express-AR', 'WRN-associated-Aneurysm', 'Aneurysm-associated-WRN', 'BACE1-targeting-Alzheimer Disease', 'Lupus Erythematosus, Systemic-negated-HP', 'GNRH1-released-Hypothalamic Neoplasms', 'CLU-involved-Neurodegenerative Diseases', 'CYP19A1-expressed-Ovarian Neoplasms', 'EMD-cause-Muscular Dystrophy, Emery-Dreifuss', 'Ossification of Posterior Longitudinal Ligament-show-PRL', 'Machado-Joseph Disease-known-ATXN3', 'MAPT-establish-Neurodegenerative Diseases', 'Leukemia, Myeloid, Acute-encode-FLT3', 'KCNH3-reduce-Machado-Joseph Disease', 'Alzheimer Disease-emerge-FGF21', 'TGM1-implicated-Cartilage Diseases', 'TP53-suppress-Neoplasms', 'TP53-treat-Neoplasms', 'LRRK2-identified-Parkinson Disease', 'Parkinson Disease-base-LRRK2', 'Parkinson Disease-develop-LRRK2', 'ZMPSTE24-farnesylate-Progeria', 'Acquired Immunodeficiency Syndrome-embraced-CD4', 'Obesity-related-INS', 'SIRT6-considered-Neoplasms', 'LOX-play-Aneurysm', 'INS-recognized-Metabolic Syndrome', 'Muscle Weakness-tend-AOC3', 'AGER-involved-Inflammation', 'RPTOR-identify-Glycogen Storage Disease Type II', 'Neurodegenerative Diseases-caused-GFAP', 'BRCA1-lead-Breast Neoplasms', 'Neoplasms-develop-BRCA1', 'Genetic Diseases, Inborn-unravel-DLX3', 'KL-associated-Metabolic Diseases', 'Metabolic Diseases-associated-KL', 'Alzheimer Disease-influenced-APOE', 'Leukemia, Myeloid, Acute-associated-ABCB1', 'ABCB1-associated-Leukemia, Myeloid, Acute', 'Trichothiodystrophy Syndromes-operate-GTF2H5', 'Inflammation-characterized-CRP', 'BDNF-increase-Dehydration', 'Infections-accompanied-CD8A', 'CD8A-study-Infections', 'COMT-inhibit-Parkinson Disease', 'GH1-associated-Death', 'Death-associated-GH1', 'GH1-attain-Death', 'CCL2-improve-Colorectal Neoplasms', 'Osteoporosis-include-CALCA', 'Osteoporosis-documented-CALCA', 'Osteoarthritis-determined-CCN4', 'WRN-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-WRN', 'SIRT7-function-Neoplasms', 'AIF1-include-Alzheimer Disease', 'CAT-protected-Drug-Related Side Effects and Adverse Reactions', 'OXT-raised-Prostatic Hyperplasia', 'DENND1A-associated-Polycystic Ovary Syndrome', 'Polycystic Ovary Syndrome-associated-DENND1A', 'MTOR-reduce-Orthostatic Intolerance', 'MME-contribute-Alzheimer Disease', 'Coronary Artery Disease-display-POMC', 'POMC-contribute-Coronary Artery Disease', 'PCSK9-bind-Hypercholesterolemia', 'CD4-caused-Death', 'Progeria-reveal-LMNA', 'MMP1-elevated-Alzheimer Disease', 'Alzheimer Disease-predict-CLU', 'Alzheimer Disease-termed-SORL1', 'SH2B1-downregulated-Parkinson Disease', 'TP53-mediated-Neoplasms', 'CIZ1-overexpressed-Neoplasms', 'PTH-measured-Osteoporotic Fractures', 'PTH-increased-Osteoporotic Fractures', 'WRN-suppress-Neoplasms', 'WRN-advance-Werner Syndrome', 'CFTR-associated-Cystic Fibrosis', 'Cystic Fibrosis-associated-CFTR', 'Hypotension-improve-INS', 'Kidney Diseases-transfected-CDKN1A', 'Death-mediated-PTH', 'Osteoarthritis-form-MAP1LC3A', 'WRN-observed-Abnormalities, Drug-Induced', 'ACE-given-Peripheral Arterial Disease', 'PARK7-mutated-Parkinson Disease', 'Mitochondrial Diseases-reflect-GDF15', 'Cardiovascular Diseases-associated-SHBG', 'SHBG-associated-Cardiovascular Diseases', 'GDF15-reflect-Mitochondrial Diseases', 'GDF15-summarize-Mitochondrial Diseases', 'Neoplasms-divided-KLK3', 'SFTPC-include-Fibrosis', 'GNRH1-differentiate-Hypogonadism', 'Hypogonadism-use-GNRH1', 'Drug-Related Side Effects and Adverse Reactions-suggested-VDR', 'EZH2-promote-Colorectal Neoplasms', 'Colorectal Neoplasms-target-EZH2', 'Dehydration-accompanied-REN', 'Myelodysplastic Syndromes-induce-ERCC1', 'JAK2-activate-Myeloproliferative Disorders', 'SUPV3L1-shown-Death', 'SUPV3L1-suppress-Death', 'Hypertension-aid-APOE', 'Neoplasms-require-IDO1', 'NR2C2-promote-Prostatic Neoplasms', 'TP53-associated-Chromosome Aberrations', 'Chromosome Aberrations-associated-TP53', 'Proteinuria-decrease-EGFR', 'CCL2-become-Prostatic Neoplasms', 'NDUFB3-develop-Immunologic Deficiency Syndromes', 'IGF1-protected-Neoplasms', 'APOE-implicated-Nervous System Diseases', 'CRP-index-Inflammation', 'VDR-determine-Fractures, Bone', 'NINJ2-contribute-Cerebral Infarction', 'MEIS1-associated-Leukemia, Myeloid, Acute', 'Leukemia, Myeloid, Acute-associated-MEIS1', 'WRN-associated-Prostatic Neoplasms', 'Prostatic Neoplasms-associated-WRN', 'MTOR-show-Carcinoma, Hepatocellular', 'PARP1-developed-Neoplasms', 'Osteosarcoma-express-CYP27B1', 'Death-interpreted-INS', 'ADIPOQ-predict-Alzheimer Disease', 'DNMT3A-contribute-Neoplasms', 'ESR1-delayed-Osteoporotic Fractures', 'SLC6A3-report-Parkinson Disease', 'Parkinson Disease-undergo-SLC6A3', 'RHCG-determine-Neoplasms', 'RHCG-suppress-Neoplasms', 'RHCG-act-Neoplasms', 'POMC-down-regulated-Alzheimer Disease', 'IGF1-determined-Alzheimer Disease', 'PTH-cause-Bone Neoplasms', 'MPO-produce-Inflammation', 'APOE-play-Death', 'INS-develop-Hyperinsulinism', 'SIRT2-affect-Alzheimer Disease', 'Neurotoxicity Syndromes-phosphorylate-TARDBP', 'ARID1A-correlate-Neoplasms', 'UCP2-affect-Neurodegenerative Diseases', 'Neoplasms-stratified-ARID1A', 'ARID1A-linked-Microsatellite Instability', 'CRP-develop-Hearing Loss', 'WRN-result-Werner Syndrome', 'SIRT6-associated-Metabolic Diseases', 'Metabolic Diseases-associated-SIRT6', 'ERCC8-recruit-Cockayne Syndrome', 'FMR1-represent-Primary Ovarian Insufficiency', 'Genetic Diseases, Inborn-exhibit-FGF23', 'NFE2L2-lead-Retinal Degeneration', 'Infections-express-CDKN2A', 'SBSN-secreted-Myelodysplastic Syndromes', 'Myelodysplastic Syndromes-underlie-SBSN', 'SBSN-associated-Neoplasms', 'Neoplasms-associated-SBSN', 'CDKN2A-recognized-Neoplasms', 'Neoplasms-recognized-CDKN2A', 'SBSN-suggest-Myelodysplastic Syndromes', 'Mitochondrial Diseases-knock-TFAM', 'Diabetes Mellitus-assessed-INS', 'Thyroid Cancer, Papillary-imply-TG', 'GAP43-include-Alzheimer Disease', 'MYH11-reduced-Prostatic Hyperplasia', 'MYH11-express-Prostatic Hyperplasia', 'PTH-shown-Fractures, Bone', 'PTH-induce-Fractures, Bone', 'PATZ1-contribute-Aneurysm', 'SLTM-used-Diabetes Mellitus, Type 2', 'SLTM-decrease-Death', 'APOE-compare-Epilepsy, Temporal Lobe', 'TH-observed-Parkinson Disease', 'Cockayne Syndrome-exhibit-COL1A1', 'Infections-result-CXCL8', 'ACHE-derived-Alzheimer Disease', 'RCAN1-implicated-Alzheimer Disease', 'Parkinson Disease-correlate-MAPT', 'RCAN1-increased-Alzheimer Disease', 'Neoplasms-release-GAST', 'GAST-use-Neoplasms', 'CFH-implicated-Blindness', 'Hypotension-require-INS', 'MYC-involved-Neoplasms', 'INS-decrease-Diabetes Mellitus', 'MYC-recognized-Precursor Cell Lymphoblastic Leukemia-Lymphoma', 'TNFRSF11B-evaluate-Fractures, Bone', 'Acute Coronary Syndrome-induce-AKT1', 'ELN-accommodate-Musculoskeletal Diseases', 'HTR6-improve-Amnesia', 'SST-reduced-Alzheimer Disease', 'Renal Insufficiency-mediated-PTH', 'IL2-considered-Drug-Related Side Effects and Adverse Reactions', 'TRA2B-upregulated-Hypoxia', 'IL16-examine-Ovarian Neoplasms', 'Ovarian Diseases-associated-IL16', 'IL16-associated-Ovarian Diseases', 'TFRC-assess-Arthritis, Rheumatoid', 'Alzheimer Disease-yield-GSK3B', 'FOXO3-influence-Alzheimer Disease', 'PRL-reflect-Hypothalamic Diseases', 'Drug-Related Side Effects and Adverse Reactions-occur-AGER', 'Skin Diseases-mediated-COL17A1', 'SLC13A3-lead-Heart Arrest', 'Neoplasms-find-CCR3', 'LRRK2-contribute-Parkinson Disease', 'EREG-given-Neoplasms', 'NR1H4-studied-Cardiovascular Diseases', 'Lentivirus Infections-used-NR1H4', 'Lentivirus Infections-detect-NR1H4', 'IL6-measured-Alzheimer Disease', 'INS-inhibit-Hyperinsulinism', 'INS-documented-Hyperinsulinism', 'Urinary Bladder, Overactive-maintain-INS', 'HMOX1-augmented-Parkinson Disease, Secondary', 'Opportunistic Infections-reported-CD4', 'Opportunistic Infections-range-CD4', 'NFE2L2-mediate-Neoplasms', 'Astrocytoma-possess-TERT', 'CST3-predict-Neoplasms', 'Osteoarthritis-associated-TGFBR2', 'TGFBR2-associated-Osteoarthritis', 'Neoplasms-display-TGFB1', 'BDNF-recruited-Dementia', 'BDNF-undergo-Dementia', 'Diabetes Mellitus, Type 2-improved-INS', 'Alzheimer Disease-affect-MAPT', 'MAPT-connect-Alzheimer Disease', 'Neuroblastoma-cause-MAPT', 'NPY-contain-Diabetes Mellitus', 'AHR-identify-Choroidal Neovascularization', 'Kidney Diseases-alter-REN', 'MYOC-observed-Glaucoma', 'GNL3-raised-Osteoarthritis', 'FTO-involved-Osteoarthritis', 'ADIPOQ-suggest-Abnormalities, Drug-Induced', 'Atherosclerosis-followed-AGER', 'APOD-expressed-Heredodegenerative Disorders, Nervous System', 'Gastritis, Atrophic-undergo-ODC1', 'Neoplasms-overexpress-ERBB2', 'PINK1-described-Parkinson Disease', 'KIR2DL4-influence-Infections', 'KIR2DL4-associated-Infections', 'Infections-associated-KIR2DL4', 'LMNA-associated-Osteoarthritis', 'Osteoarthritis-associated-LMNA', 'MGMT-stratify-Glioblastoma', 'Atherosclerosis-affect-WRN', 'WRN-enhance-Inflammation', 'WRN-regulate-Inflammation', 'GH1-diminished-Obesity', 'LRG1-induced-Inflammation', 'KLK3-participate-Prostatic Neoplasms', 'KLK3-investigate-Prostatic Neoplasms', 'APOE-progress-Alzheimer Disease', 'Alzheimer Disease-increase-MAPT', 'Alzheimer Disease-redistributed-STX1A', 'PRKN-ameliorate-Mitochondrial Diseases', 'AHR-induce-Hearing Loss', 'Osteoarthritis-bear-SOX9', 'IL15-associated-Sarcopenia', 'Sarcopenia-associated-IL15', 'Lymphoma, T-Cell-postulated-TET2', 'PON1-investigated-Atherosclerosis', 'DNAJC7-propose-Neurodegenerative Diseases', 'KL-decreased-Dwarfism, Pituitary', 'IGF2-documented-Neoplasms', 'PINK1-play-Mitochondrial Diseases', 'VPS35-found-Parkinson Disease', 'Dehydration-influence-KL', 'KL-lead-Death', 'Stroke-block-FOXO3', 'Polycystic Ovary Syndrome-experience-AMH', 'PTN-know-Osteoporosis', 'Diabetes Mellitus-emerge-ZMAT3', 'Heart Arrest-cause-WRN', 'CARS1-guarantee-Neoplasms', 'Infections-use-CD4', 'CRTC1-associated-Neoplasms', 'Neoplasms-associated-CRTC1', 'Death-associate-BCL2', 'BCL2-associate-Death', 'Hypertrophy-exhibit-MTOR', 'Glucose Metabolism Disorders-assess-INS', 'CIC-maintain-Neoplasms', 'PTEN-expressed-Diabetes Mellitus', 'LMNA-exert-Drug-Related Side Effects and Adverse Reactions', 'PTEN-appear-Diabetic Foot', 'Leukemia, Lymphocytic, Chronic, B-Cell-expected-MTOR', 'MAPT-target-Neurodegenerative Diseases', 'Death-include-CD4', 'Immunologic Deficiency Syndromes-carry-TINF2', 'GGCX-associated-Coagulation Protein Disorders', 'Coagulation Protein Disorders-associated-GGCX', 'GGCX-known-Coagulation Protein Disorders', 'Neoplasms-associated-TF', 'TF-associated-Neoplasms', 'Neoplasms-increase-TF', 'SOD2-suppress-Neoplasms', 'TP53-rescue-Growth Disorders', 'EZR-increased-Alzheimer Disease', 'AKT1-abolish-Neoplasms', 'BIRC5-expressed-Neoplasms', 'BIRC5-associated-Neoplasms', 'Neoplasms-associated-BIRC5', 'SLC41A1-downregulated-Neoplasms', 'LIN28A-enhance-Disorders of Sex Development', 'Muscular Dystrophy, Emery-Dreifuss-bear-EMD', 'Neoplasms-exhibit-SIRT1', 'TLR4-linked-Cardiovascular Diseases', 'Diabetes Mellitus-taken-INS', 'SIRT1-treat-Diabetes Mellitus', 'NOS2-required-Chemical and Drug Induced Liver Injury', 'Weight Loss-associated-CD8A', 'CD8A-associated-Weight Loss', 'BCL2-protected-Mitochondrial Diseases', 'KL-include-Cardiovascular Diseases', 'IL1RN-associated-Death', 'Death-associated-IL1RN', 'SV2A-represent-Alzheimer Disease', 'Pigmentation Disorders-produced-TYR', 'STX6-increase-Alzheimer Disease', 'INS-instituted-Immunologic Deficiency Syndromes', 'MAPT-accumulated-Alzheimer Disease', 'SIRT1-act-Skin Diseases', 'Telangiectasis-associated-KL', 'KL-associated-Telangiectasis', 'BRAF-draw-Death', 'TERT-identified-Thyroid Neoplasms', 'Alzheimer Disease-occupied-AVP', 'ANK3-reported-Progeria', 'CCDC88A-known-Neoplasms', 'CCDC88A-suppress-Neoplasms', 'Glucose Metabolism Disorders-ameliorate-INS', 'LPL-influence-Ovarian Diseases', 'Frontotemporal Lobar Degeneration-address-MAPT', 'BCL2-involved-Death', 'INS-accelerate-Diabetes Mellitus', 'RECQL5-relieve-Heart Arrest', 'Hypercalcemia-accompany-PTH', 'Neoplasms-express-TNF', 'Diabetes Mellitus, Type 2-prescribed-INS', 'Hypothalamic Diseases-reduce-POMC', 'CREBBP-implicate-Diabetes Mellitus, Type 2', 'ACE-diagnosed-Heart Failure', 'Heart Failure-benefit-ACE', 'DSC2-known-Arrhythmogenic Right Ventricular Dysplasia', 'DSC2-predispose-Arrhythmogenic Right Ventricular Dysplasia', 'Choroidal Neovascularization-bind-VEGFA', 'Bloom Syndrome-contain-VIM', 'Bloom Syndrome-suggest-VIM', 'CDR2-occur-Lupus Erythematosus, Systemic', 'SIRT1-become-Aneurysm', 'SIRT1-mediate-Uterine Cervical Neoplasms', 'Alzheimer Disease-appear-MAPT', 'Werner Syndrome-include-WRN', 'KL-possess-Neoplasms', 'SIRT1-shown-Glucose Metabolism Disorders', 'CRP-observed-Pneumonia', 'APOE-determined-Alzheimer Disease', 'Ataxia Telangiectasia-complement-ATM', 'CAT-used-Death', 'CAT-prevent-Death', 'Death-prevent-CAT', 'Death-associated-CASP3', 'CASP3-associated-Death', 'SPARC-decreased-Intervertebral Disc Degeneration', 'Alzheimer Disease-decreased-TF', 'Diabetes Mellitus, Type 2-considered-INS', 'CD79A-measured-Alzheimer Disease', 'SIRT1-lead-Neoplasms', 'SIRT1-impart-Neoplasms', 'SHBG-associated-Hip Fractures', 'Hip Fractures-associated-SHBG', 'INS-affect-Diabetes Mellitus, Type 2', 'Death-display-CD8A', 'Inflammation-seen-CRP', 'Immunologic Deficiency Syndromes-associated-CRP', 'CRP-associated-Immunologic Deficiency Syndromes', 'CD4-associated-Brain Ischemia', 'Brain Ischemia-associated-CD4', 'NTRK3-elevated-Diabetic Nephropathies', 'Nervous System Diseases-occur-MTRR', 'MSRA-play-Death', 'SIRT1-prevent-Hypertension', 'LMNA-lead-Genetic Diseases, Inborn', 'SIRT6-inhibit-Fibrosis', 'Osteoarthritis-observe-CLU', 'BMP2-observed-Fractures, Bone', 'Neoplasms-contain-TP53', 'TP53-appear-Neoplasms', 'Muscular Dystrophies-point-IL6', 'INS-offer-Diabetes Mellitus', 'FGF23-observed-Alzheimer Disease', 'Polycystic Ovary Syndrome-show-AMH', 'PCSK9-confirmed-Hyperlipoproteinemia Type II', 'RAE1-associated-Neoplasms', 'Neoplasms-associated-RAE1', 'SRSF1-upregulated-Neoplasms', 'Epilepsy-express-ODC1', 'TXN-clone-Leukemia-Lymphoma, Adult T-Cell', 'SIRT1-provide-Neurodegenerative Diseases', 'SIRT6-reduced-Alzheimer Disease', 'WRN-associated-Aging, Premature', 'Aging, Premature-associated-WRN', 'PRL-validated-Dementia', 'INS-implicated-Hyperinsulinism', 'RAC1-occur-Hypoxia', 'CSTB-linked-Genetic Diseases, Inborn', 'F8-result-Hemorrhage', 'REN-measured-Hypertension', 'BCL2L11-regulate-Inflammation', 'BCL2L11-declined-Uremia', 'KL-predict-Glioblastoma', 'KL-detected-Glioblastoma', 'EPO-attenuate-Breast Neoplasms', 'Glucose Metabolism Disorders-suppressed-SIRT6', 'IL10-involved-Osteoporosis', 'SLC6A3-decreased-Parkinson Disease, Secondary', 'CD4-taken-Acquired Immunodeficiency Syndrome', 'INS-investigated-Aging, Premature', 'KL-decrease-Kidney Failure, Chronic', 'Death-moderated-APOE', 'Heart Arrest-block-PRKAA2', 'TERT-confer-Neoplasms', 'Glucose Intolerance-explained-INS', 'TERT-summarize-Neoplasms', 'REN-remain-Syncope', 'Hypotension-produce-REN', 'PRKAA2-mediated-Primary Ovarian Insufficiency', 'CRP-assessed-Dementia', 'Necrosis-identified-TERT', 'Necrosis-associated-TERT', 'TERT-associated-Necrosis', 'Infections-expose-TAT', 'CYP11B2-contribute-Cushing Syndrome', 'Necrosis-found-TERT', 'Prostatic Neoplasms-blocked-SIRT1', 'AR-govern-Prostatic Neoplasms', 'Sarcopenia-associate-AKT1', 'AKT1-associate-Sarcopenia', 'Alzheimer Disease-accounted-HK1', 'POSTN-determined-Diabetic Nephropathies', 'CRP-linked-Intracranial Arterial Diseases', 'POSTN-demonstrate-Diabetes Mellitus, Type 2', 'Alzheimer Disease-prevent-APOE', "Fuchs' Endothelial Dystrophy-situated-TCF4", 'Acquired Immunodeficiency Syndrome-caused-NOS2', 'GH1-play-Osteoporosis', 'FST-involved-Inflammation', 'CRP-defined-Hyperhomocysteinemia', 'KL-characterize-Atherosclerosis', 'HSPA5-decrease-Calcinosis', 'KL-down-regulated-Inflammation', 'KL-function-Neoplasms', 'CRP-linked-Death', 'ERCC4-result-Xeroderma Pigmentosum', 'MTOR-linked-Colonic Neoplasms', 'VEGFA-account-Hematuria', 'PTEN-reveal-Ovarian Neoplasms', 'Hyperkalemia-associated-ACE', 'ACE-associated-Hyperkalemia', 'PLIN2-associated-Neoplasms', 'Neoplasms-associated-PLIN2', 'MTOR-reduce-Prostatic Neoplasms', 'Hip Fractures-exposed-ACE', 'MTOR-show-Prostatic Neoplasms', 'MTOR-influence-Prostatic Neoplasms', 'INS-aimed-Diabetes Mellitus', 'TNNT1-correlate-Death', 'Goiter-show-SERPINA7', 'SIRT1-found-Polycystic Kidney Diseases', 'SIRT1-delay-Polycystic Kidney Diseases', 'Muscular Diseases-result-ETFDH', 'Muscular Diseases-manifest-ETFDH', 'LMNA-suffer-Atherosclerosis', 'ZMPSTE24-reduce-Neoplasms', 'MX2-control-Infections', 'MX2-serve-Infections', 'PTH-exclude-Osteoporosis', 'Alzheimer Disease-extended-MAPT', 'CISH-indicate-Infections', 'ALB-increase-Death', 'AGER-activate-Inflammation', 'MTOR-slow-Tuberous Sclerosis', 'BCL2-rise-Lymphoma', 'EPHA2-represent-Esophageal Squamous Cell Carcinoma', 'SIRT1-detected-Cardiomyopathy, Dilated', 'Obesity-classified-APOE', 'SOD1-cause-Anemia', 'FGF23-evaluate-Fractures, Bone', 'SOD1-decrease-Death', 'FGF23-modified-Renal Insufficiency, Chronic', 'GZMB-compare-Hodgkin Disease', 'TTR-cause-Multiple Myeloma', 'TTR-known-Amyloidosis', 'CYP17A1-evaluated-Breast Neoplasms', 'Obesity-suppressed-INS', 'TIMP1-regarded-Cardiomyopathy, Dilated', 'MS4A4A-associated-Alzheimer Disease', 'Alzheimer Disease-associated-MS4A4A', 'CRISP1-derived-Neoplasms', 'Alzheimer Disease-used-INS', 'Acidosis-produce-INS', 'SERPINA1-play-Diverticulum', 'TNFSF12-explore-Muscular Diseases', 'SIRT7-up-regulated-Carcinoma, Hepatocellular', 'SIRT7-proposed-Neoplasms', 'SIRT7-cause-Carcinoma, Hepatocellular', 'SIRT7-make-Neoplasms', 'ELN-associated-Atherosclerosis', 'Atherosclerosis-associated-ELN', 'CD9-increase-Atherosclerosis', 'SIRT3-decline-Metabolic Diseases', 'SIRT3-affect-Cardiovascular Diseases', 'SIRT1-attenuate-Drug-Related Side Effects and Adverse Reactions', 'Inflammation-diminish-FGF23', 'EREG-assessed-Neoplasm Invasiveness', 'Neoplasms-associated-IGF2', 'IGF2-associated-Neoplasms', 'CFTR-predispose-Diabetes Mellitus', 'Genetic Diseases, Inborn-result-LMNA', 'Genetic Diseases, Inborn-encode-LMNA', 'Memory Disorders-measured-GZMB', 'PRKAB1-decreased-Osteoarthritis', 'PRKAB1-inhibit-Osteoarthritis', 'PRKAB1-associated-Osteoarthritis', 'Osteoarthritis-associated-PRKAB1', 'SMN1-cause-Muscular Atrophy, Spinal', 'Erectile Dysfunction-mimic-NFE2L2', 'Erectile Dysfunction-potentiate-NFE2L2', 'CP-increased-Diabetes Mellitus', 'Glucose Metabolism Disorders-reverse-INS', 'HIV Infections-measured-CD4', 'DICER1-associated-Disease', 'Disease-associated-DICER1', 'XRCC1-contribute-Neoplasms', 'IGF1-implicated-Alzheimer Disease', 'CRP-use-Arteriovenous Fistula', 'Hypertension-show-PON1', 'APOE-adjusted-Stroke', 'FBL-induce-Infections', 'Infections-reduce-FBL', 'ADIPOQ-play-Atherosclerosis', 'INS-investigated-Congenital Hyperinsulinism', 'PDE1A-associated-Cerebrovascular Disorders', 'Cerebrovascular Disorders-associated-PDE1A', 'TMEM106B-linked-Brain Diseases', 'INS-noted-Drug-Related Side Effects and Adverse Reactions', 'TMEM106B-result-Lysosomal Storage Diseases', 'INS-found-Glucose Intolerance', 'MAPT-cause-Alzheimer Disease', 'MAPT-contribute-Memory Disorders', 'CRP-increased-Chronic Disease', 'LMNB1-understand-Leukodystrophy, Metachromatic', 'Carcinoma, Hepatocellular-require-MAPK1', 'IDE-compare-Alzheimer Disease', 'IDE-oxidized-Alzheimer Disease', 'HERPUD1-performed-Choroiditis', 'HERPUD1-associated-Choroiditis', 'Choroiditis-associated-HERPUD1', 'TTR-contain-Heart Diseases', 'MGMT-explain-Glioblastoma', 'NAP1L1-compare-Infections', 'IL2-measured-Infections', 'KL-alleviate-Heart Diseases', 'Breast Neoplasms-reveal-KL', 'FMR1-associated-Neurotoxicity Syndromes', 'Neurotoxicity Syndromes-associated-FMR1', 'SOD1-involved-Amyotrophic Lateral Sclerosis', 'SIRT1-induced-Metabolic Syndrome', 'BABAM2-expressed-Herpes Zoster', 'S100A12-contribute-Atherosclerosis', 'TNFSF11-emerge-Bone Neoplasms', 'CYP2D6-consider-Parkinson Disease', 'RETN-serve-Metabolic Syndrome', 'GFAP-used-Neurodegenerative Diseases', 'TNF-determined-Lung Neoplasms', 'MTOR-exploit-Neoplasms', 'Rhabdomyosarcoma, Alveolar-identify-FOXO1', 'MMP28-upregulated-Idiopathic Pulmonary Fibrosis', 'FOXO1-help-Rhabdomyosarcoma, Alveolar', 'DIRAS3-develop-X-Linked Combined Immunodeficiency Diseases', 'HDAC2-lead-Pulmonary Disease, Chronic Obstructive', 'IRF1-activated-Infections', 'Leukemia, Myeloid, Acute-express-CD302', 'CD302-examine-Leukemia, Myeloid, Acute', 'AIDS Arteritis, Central Nervous System-associated-MAPT', 'MAPT-associated-AIDS Arteritis, Central Nervous System', 'VWF-evaluate-Hemorrhage', 'Huntington Disease-linked-HTT', 'IL6-associated-Confusion', 'Confusion-associated-IL6', 'Muscular Dystrophies-contain-VIP', 'ESR1-implicated-Neoplasms', 'F8-bypass-Hemophilia A', 'Death-increase-CRP', 'MTHFR-cause-Anemia, Megaloblastic', 'CYP19A1-investigate-Alzheimer Disease', 'FTO-show-Cardiac Output, Low', 'POMC-found-Neoplasms', 'NPEPPS-predict-Prostatic Hyperplasia', 'LGALS1-described-Neoplasms', 'INS-play-Ovarian Diseases', 'LEF1-expressed-Neoplasms', 'ST8SIA2-compare-Hemolytic-Uremic Syndrome', 'KL-investigate-Pancreatic Neoplasms', 'Pancreatic Neoplasms-antagonize-KL', 'INS-calculated-Diabetes Mellitus', 'Inflammation-characterized-NELFCD', 'Liver Cirrhosis-show-ALPI', 'CRP-mediate-Arthritis', 'Diabetes Mellitus-show-MAPT', 'EREG-play-Atherosclerosis', 'CRP-experience-Postoperative Cognitive Complications', 'Thalassemia-found-ALAS2', 'Neurotoxicity Syndromes-involved-EIF2AK2', 'Anemia-associated-TF', 'TF-associated-Anemia', 'CETP-associated-Hypertension', 'Hypertension-associated-CETP', 'Hypothalamic Diseases-involved-PRL', 'Colorectal Neoplasms, Hereditary Nonpolyposis-harbour-MSH6', 'Aneurysm-exclude-CRP', 'ACE-reverse-Hypertension', 'Alzheimer Disease-find-CREM', 'APOE-share-Alzheimer Disease', 'SRSF2-associated-Leukemia, Myeloid, Acute', 'Leukemia, Myeloid, Acute-associated-SRSF2', 'IL2-associated-Necrosis', 'Necrosis-associated-IL2', 'PLA2G3-provoke-Death', 'Inflammation-interact-HABP2', 'NOS2-confirm-Inflammation', 'INS-induced-Hyperinsulinism', 'TARDBP-regarded-Amyotrophic Lateral Sclerosis', 'CDK7-elevated-Alzheimer Disease', 'NLRP3-linked-Inflammation', 'STAG3-segregate-Infertility, Female', 'STAG3-associated-Infertility, Female', 'Infertility, Female-associated-STAG3', 'Infections-acquire-HSPD1', 'HSPD1-lead-Atherosclerosis', 'Obesity-exhibit-INS', 'MAPT-compare-Tauopathies', 'MAPT-predict-Dementia', 'AMH-studied-Ovarian Diseases', 'GDF15-triggered-Mitochondrial Diseases', 'Ovarian Neoplasms-identify-TP53', 'TP53-found-Neoplasms', 'SERPINF1-stabilize-Psychomotor Disorders', 'YAP1-ameliorate-Osteoarthritis', 'FOXO3-lead-Heart Arrest', 'MSTN-evaluate-Sarcopenia', 'MSTN-diagnose-Sarcopenia', 'MSTN-associated-Malnutrition', 'Malnutrition-associated-MSTN', 'TRH-exert-Psychomotor Disorders', 'MAPT-continue-Dementia', 'KL-play-Atherosclerosis', 'KL-affect-Kidney Diseases', 'APOE-come-Alzheimer Disease', 'Hypothalamic Diseases-remain-OXT', 'EGR2-activate-Acute Kidney Injury', 'MMP2-facilitate-Vascular Calcification', 'IL2-associated-Infections', 'Infections-associated-IL2', 'IGFBP3-predict-Death', 'IGFBP1-predict-Death', 'APOE-exhibit-Cerebral Infarction', 'APOE-increase-Infarction', 'INS-accompany-Obesity', 'SIRT6-associated-Neoplasms', 'Neoplasms-associated-SIRT6', 'SIRT6-enable-Neoplasms', 'Death-tested-CRP', 'Death-contain-CRP', 'EPOR-detected-Neoplasms', 'Neoplasms-promote-SIRT1', 'MSRA-required-Cataract', 'FGF23-associated-Hypertension', 'Hypertension-associated-FGF23', 'ACMSD-represent-Neurodegenerative Diseases', 'SLC6A3-distinguish-Parkinson Disease', 'Protein-Energy Malnutrition-use-ALB', 'KLK3-use-Prostatic Neoplasms', 'KLK3-predict-Prostatic Neoplasms', 'INS-attributed-Myoclonic Epilepsies, Progressive', 'Carcinoma, Hepatocellular-transfect-RGN', 'Alzheimer Disease-mitigate-APOE', 'TP53-assess-Carcinoma, Basal Cell', 'BMP6-increased-Alzheimer Disease', 'Aneurysm-known-INS', 'INS-arise-Obesity', 'PWWP3A-combined-Precursor Cell Lymphoblastic Leukemia-Lymphoma', 'BCL6-define-Lymphoma', 'REN-indicated-Hypertension', 'Hyperinsulinism-vary-INS', 'Infections-associated-RHOA', 'RHOA-associated-Infections', 'Infections-induce-RHOA', 'ACE-show-Migraine Disorders', 'ACE-use-Headache', 'PATE1-share-Asthenozoospermia', 'PATE1-exhibit-Asthenozoospermia', 'IL6-include-Neurodegenerative Diseases', 'NR3C2-promote-Aneurysm', 'NR3C2-prevent-Cardiovascular Diseases', 'RELN-preserved-Alzheimer Disease', 'IL6-compare-Heart Diseases', 'PLIN2-associated-Muscular Atrophy', 'Muscular Atrophy-associated-PLIN2', 'HP-oxidize-Alzheimer Disease', 'Polycystic Kidney Diseases-elucidate-PKD1', 'PKD1-display-Hypoxia', 'PTGER2-associated-Kidney Diseases, Cystic', 'Kidney Diseases, Cystic-associated-PTGER2', 'Tauopathies-encoded-MAPT', 'Breast Neoplasms-immunostain-WRAP53', 'MAGT1-associated-Colorectal Neoplasms', 'Colorectal Neoplasms-associated-MAGT1', 'ESR2-increase-Colorectal Neoplasms', 'MME-suggest-Alzheimer Disease', 'ELN-re-expressed-Wounds and Injuries', 'Death-express-CDKN2A', 'KL-serve-Neoplasms', 'KL-decreased-Hypertension', 'Malnutrition-detect-ALB', 'ELN-compare-Amyotrophic Lateral Sclerosis', 'CASP8-increase-Huntington Disease', 'MAPT-hyperphosphorylated-Alzheimer Disease', 'LMNA-develop-Retinal Degeneration', 'ELN-affected-Amyotrophic Lateral Sclerosis', 'Death-proportion-APOA1', 'MAGEA3-generated-Neoplasms', 'SNCG-use-Breast Neoplasms', 'SNCG-increased-Breast Neoplasms', 'CHGA-indicate-Neoplasms', 'Headache Disorders, Secondary-start-DDX41', 'SIRT3-express-Neoplasms', 'SIRT3-need-Neoplasms', 'SIRT3-enhance-Neoplasms', 'SIRT3-elevated-Stomach Neoplasms', 'Neoplasms-raise-LMNA', 'ACE-used-Hypertension', 'GDF15-increased-Skin Diseases', 'INS-impair-Glucose Intolerance', 'RGN-measured-Seizures', 'PLAU-contribute-Breast Neoplasms', 'IDH1-detected-Leukemia, Myeloid, Acute', 'S100A10-increased-Alzheimer Disease', 'ANGPTL2-accelerate-Heart Diseases', 'CHI3L1-disappear-Alzheimer Disease', 'Death-rose-CRP', 'INS-studied-Diabetes Mellitus, Type 2', 'Hypoglycemia-cause-INS', 'Ischemia-modify-ALB', 'SOX2-linked-Chronic Disease', 'NLRP3-treat-Postoperative Cognitive Complications', 'DBI-upregulated-Obesity', 'NLRP3-target-Postoperative Cognitive Complications', 'SPARCL1-associated-Alzheimer Disease', 'Alzheimer Disease-associated-SPARCL1', 'SPARCL1-accelerate-Alzheimer Disease', 'Werner Syndrome-derived-WRN', 'SHBG-used-Hypogonadism', 'CERS1-mediate-Sphingolipidoses', 'AHSG-associated-Sarcopenia', 'Sarcopenia-associated-AHSG', 'Death-related-JPH3', 'JPH3-play-Death', 'TG-suggest-Adrenal Insufficiency', 'TG-associated-Anemia', 'Anemia-associated-TG', 'GH1-decrease-Renal Insufficiency, Chronic', 'GH1-stimulate-Glucose Metabolism Disorders', 'GH1-provide-Renal Insufficiency, Chronic', 'Rothmund-Thomson Syndrome-transmitted-RECQL4', 'CD4-trend-Infections', 'KL-influence-Lung Neoplasms', 'CRP-serve-Atherosclerosis', 'KL-show-Fibrosis', 'KL-serve-Lung Neoplasms', 'CD22-contribute-Alzheimer Disease', 'CD22-play-Alzheimer Disease', 'KL-assumed-Kidney Diseases', 'KL-correlated-Fibrosis', 'PSEN1-associated-Death', 'Death-associated-PSEN1', 'PSEN1-result-Death', 'SPP1-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-SPP1', 'INS-predisposed-Diabetes Mellitus, Type 2', 'POMC-suppressed-Adrenal Gland Neoplasms', 'SIRT7-induce-Metabolic Diseases', 'INS-control-Diabetes Mellitus, Type 2', 'IL10-related-Infections', 'Alzheimer Disease-encode-VASP', 'GAST-include-Gingival Overgrowth', 'GAST-associated-Infections', 'Infections-associated-GAST', 'Blind Loop Syndrome-indicate-GAST', 'MUC1-involved-Neoplasms', 'MUC1-detected-Breast Neoplasms', 'MTNR1A-shift-Alzheimer Disease', 'CFH-lead-Glomerulonephritis', 'HIF1A-reveal-Myelodysplastic Syndromes', 'HIF1A-activated-Myelodysplastic Syndromes', 'CRP-predict-Arthritis, Infectious', 'BDNF-assessed-Alzheimer Disease', 'BDNF-detected-Alzheimer Disease', 'BDNF-determine-Alzheimer Disease', 'POLD1-identify-Neoplasms', 'POLD1-altered-Diabetes Mellitus', 'Fragile X Syndrome-result-FMR1', 'HHLA2-associated-Carcinoma, Pancreatic Ductal', 'Carcinoma, Pancreatic Ductal-associated-HHLA2', 'ELN-polarize-Vascular Calcification', 'PPIB-protect-Nerve Degeneration', 'Carcinoma, Hepatocellular-overexpressed-SIRT1', 'SIRT1-function-Neoplasms', 'Carcinoma, Hepatocellular-inhibited-SIRT1', 'SIRT1-influence-Carcinoma, Hepatocellular', 'SIRT1-result-Neoplasms', 'SIRT1-develop-Neoplasms', 'APOE-live-Neoplasms', 'MTOR-treat-Primary Ovarian Insufficiency', 'MLXIP-distinguish-Melanoma', 'POSTN-correlate-Bone Diseases', 'LRRK2-cause-Parkinson Disease', 'Parkinson Disease-discuss-LRRK2', 'Neurologic Manifestations-result-MAPT', 'POU5F1-occur-Teratoma', 'Cardiovascular Diseases-considered-CRP', 'Huntington Disease-activated-PRKAA2', 'PRKAA2-counteract-Drug-Related Side Effects and Adverse Reactions', 'Prostatic Neoplasms-increase-KLK3', 'GDF15-increase-Colorectal Neoplasms', 'MTHFR-include-Genetic Diseases, Inborn', 'TAF1-show-Neuroblastoma', 'Hypotension, Orthostatic-associated-APOE', 'APOE-associated-Hypotension, Orthostatic', 'GDF15-promote-Colorectal Neoplasms', 'SCGB3A2-reported-Neoplasms', 'Infertility, Female-caused-SHBG', 'NR2C2-cloned-Hypothalamic Neoplasms', 'LMNA-impair-Leukemia, Biphenotypic, Acute', 'CRP-underlie-Infections', 'LMNA-impair-Disorders of Sex Development', 'Obesity-regulate-PCK2', 'KLK3-defined-Death', 'Idiopathic Pulmonary Fibrosis-increased-GDF15', 'THBS1-involved-Neoplasms', 'SLC6A3-correlated-Parkinson Disease', 'NPPA-infused-Muscle Hypertonia', 'HIV Infections-induce-TERF2', 'TERF2-rejuvenate-Arbovirus Infections', 'PON1-play-Atherosclerosis', 'INS-represent-Cerebrovascular Disorders', 'Anemia-suffer-ALB', 'IL6-differ-Sarcopenia', 'TARDBP-linked-Alzheimer Disease', 'PTH-used-Immunologic Deficiency Syndromes', 'HCRT-produced-Hypothalamic Neoplasms', 'HCRT-regulate-Glucose Metabolism Disorders', 'FGF19-examined-Breast Neoplasms', 'HCRT-result-Narcolepsy', 'WRN-act-Breast Neoplasms', 'WRN-result-Breast Neoplasms', 'CD4-indicate-Acquired Immunodeficiency Syndrome', 'CAV1-cause-Lipodystrophy, Congenital Generalized', 'THPO-influence-Leukemia, Myeloid, Acute', 'SHBG-differ-HIV Infections', 'SHBG-compare-HIV Infections', 'PRKN-lead-Parkinson Disease', 'VWF-increase-von Willebrand Diseases', 'von Willebrand Diseases-increase-VWF', 'BACE1-examine-Alzheimer Disease', 'MTOR-increase-Diabetes Mellitus, Type 2', 'SERPINF1-altered-Alzheimer Disease', 'INS-elevated-Alzheimer Disease', 'SERPINF1-reduced-Alzheimer Disease', 'ABCB1-targeted-Leukemia, Myeloid, Acute', 'Hematologic Diseases-include-ABCB1', 'MARCKSL1-define-Leukemia, Myeloid, Acute', 'ADIPOQ-adjusted-Obesity', 'Werner Syndrome-consist-HPRT1', 'PPARG-improve-Metabolic Diseases', 'RECQL4-amplified-Breast Neoplasms', 'ERBB2-include-Neoplasms', 'RECQL4-impair-Breast Neoplasms', 'APOE-investigate-Alzheimer Disease', 'FGF23-increase-Renal Insufficiency, Chronic', 'ALPP-reduce-Calcinosis', 'Osteoporosis-affect-FGF23', 'CD8A-show-Heart Arrest', 'CD8A-correlated-Osteoporotic Fractures', 'CTSD-serve-Skin Diseases', 'SFRP1-associated-Stomach Neoplasms', 'Stomach Neoplasms-associated-SFRP1', 'INS-associated-Anophthalmos', 'Anophthalmos-associated-INS', 'TXN-include-Inflammation', 'LPL-contribute-Metabolic Diseases', 'Obesity-use-INS', 'GIP-linked-Obesity', 'Drug-Related Side Effects and Adverse Reactions-caused-ACHE', 'TTN-serve-Hypotension', 'FABP3-prevent-Neurotoxicity Syndromes', 'HIF1A-involved-Hypoxia', 'von Willebrand Diseases-result-VWF', 'Necrosis-stimulate-HGF', 'SIRT1-retain-Colorectal Neoplasms', 'Hypertension-identified-REN', 'REN-identified-Hypertension', 'CRP-study-Inflammation', 'Heart Arrest-involve-KL', 'SLC1A5-involved-Neoplasms', 'Inflammation-include-FOXO3', 'CD2-promote-Arbovirus Infections', 'INS-confirm-Insulinoma', 'Optic Neuritis-occur-TNF', 'Kidney Diseases-prolong-ACE', 'Metabolic Diseases-involve-VDR', 'MSTN-modulate-Sarcopenia', 'SLC5A2-demonstrated-Diabetes Mellitus, Type 2', 'HSH2D-increase-Inflammation', 'HSH2D-wane-Inflammation', 'IL15-involved-Inflammation', 'NEFL-investigate-Vision Disorders', 'HPCA-increased-Alzheimer Disease', 'Breast Neoplasms-performed-BRCA1', 'SIRT1-reduce-Osteoarthritis', 'IL6-measured-Inflammation', 'CHMP4B-recruited-Progeria', 'MYOD1-elevated-Idiopathic Pulmonary Fibrosis', 'Neoplasms-respond-TMEM37', 'FGF23-impact-Aneurysm', 'APOE-assess-Learning Disabilities', 'APOE-associated-Learning Disabilities', 'Learning Disabilities-associated-APOE', 'XIAP-developed-Leukemia, Myeloid, Acute', 'Death-estimated-ADIPOQ', 'XIAP-contribute-Leukemia, Myeloid, Acute', 'TNFSF10-lead-Leukemia, Myeloid, Acute', 'TNFSF10-warranted-Leukemia, Myeloid, Acute', 'APOE-influence-Hypertension', 'HIV Infections-characterize-CD4', 'TH-play-Parkinson Disease', 'TH-cause-Parkinson Disease', 'ALPP-affect-Renal Insufficiency, Chronic', 'VEGFA-examine-Melanoma', 'VEGFA-use-Melanoma', 'Alzheimer Disease-colocalized-MAPT', 'Metabolic Diseases-related-INS', 'APOE-present-Alzheimer Disease', 'S100A8-evaluated-Infections', 'CASP3-co-express-Ischemia', 'INS-deliver-Chemical and Drug Induced Liver Injury', 'Hypocalcemia-increase-PTH', 'KL-reduce-Carcinoma, Hepatocellular', 'NGB-provide-Hemorrhage', 'SIRT6-expressed-Ovarian Neoplasms', 'SIRT6-localize-Leukemia, Myeloid, Acute', 'SIRT1-play-Leukemia-Lymphoma, Adult T-Cell', 'TREM2-endowed-Neurodegenerative Diseases', 'Glucose Metabolism Disorders-promote-HK2', 'CTSD-involved-Alzheimer Disease', 'Alzheimer Disease-suggested-CTSD', 'Alzheimer Disease-involved-CTSD', 'CTSD-altered-Alzheimer Disease', 'ALB-associated-Euthyroid Sick Syndromes', 'Euthyroid Sick Syndromes-associated-ALB', 'Renal Insufficiency, Chronic-associated-CD4', 'CD4-associated-Renal Insufficiency, Chronic', 'RUNX1-detected-Myelodysplastic Syndromes', 'CD8A-favor-Inflammation', 'Hypoglycemia-occur-INS', 'P2RY11-reduce-Inflammation', 'ACE2-associated-Sarcopenia', 'Sarcopenia-associated-ACE2', 'CYP27B1-associated-Fractures, Bone', 'Fractures, Bone-associated-CYP27B1', 'Polycystic Kidney Diseases-identified-TSC2', 'PRL-determined-Prostatic Neoplasms', 'ERBB2-become-Neoplasms', 'DLX2-exhibit-Neoplasms', 'SLTM-inhibit-Neoplasms', 'Fibrosis-correlate-ECSIT', 'ECSIT-study-Mitochondrial Diseases', 'SIRT1-localize-Neoplasms', 'TWSG1-found-Neoplasms', 'SIRT1-affect-Neoplasms', 'HSPA12A-identify-Stroke', 'INSR-disrupted-Diabetes Mellitus', 'Hepatitis B-associated-TERT', 'TERT-associated-Hepatitis B', 'Myelodysplastic Syndromes-associate-MYBL2', 'MYBL2-associate-Myelodysplastic Syndromes', 'TREX1-translocate-Rupture', 'MYBL2-identify-Myelodysplastic Syndromes', 'NAMPT-counter-Metabolic Diseases', 'TSPO-observed-Alzheimer Disease', 'CD4-start-Death', 'PTH-related-Osteoporosis', 'TSPO-increase-Inflammation', 'Ischemia-reinforce-NOS2', 'Skin Diseases-involve-AHR', 'Skin Diseases-treat-ELN', 'TARDBP-classified-Plaque, Amyloid', 'AR-related-Prostatic Hyperplasia', 'MDK-implicate-Renal Insufficiency, Chronic', 'von Hippel-Lindau Disease-inhibited-AIFM2', 'INS-stimulate-Hyperinsulinism', 'Malaria-span-CS', 'CST3-predict-Death', 'IL15-compare-Leishmaniasis, Cutaneous', 'F8-prolong-Hemorrhage', 'MAPK8-treat-Osteoporosis', 'BMP15-cause-Infertility, Female', 'Heart Failure-reveal-TNNT1', 'PSEN1-associated-Cerebral Amyloid Angiopathy', 'Cerebral Amyloid Angiopathy-associated-PSEN1', 'PSEN1-related-Cerebral Amyloid Angiopathy', 'KL-elevated-Acromegaly', 'HDC-found-Neurodegenerative Diseases', 'GDF15-link-Inflammation', 'Neoplasms-considered-GRN', 'Pancreatic Neoplasms-evaluated-NFE2L2', 'GRN-associated-Gastrointestinal Stromal Tumors', 'Gastrointestinal Stromal Tumors-associated-GRN', 'CST3-measure-Obesity', 'TNFRSF4-translated-Neoplasms', 'IGF1-emerge-Cerebrovascular Disorders', 'REN-decreased-Hypertension', 'Fractures, Bone-observed-CRP', 'PTH-represent-Osteoporosis', 'MAPT-manifest-Neurodegenerative Diseases', 'MAPT-detected-Gliosis', 'TGFA-lead-Genetic Diseases, Inborn', 'TGFA-implicated-Genetic Diseases, Inborn', 'HPRT1-identified-Osteoarthritis', 'Lupus Erythematosus, Systemic-reverse-MTOR', 'MTOR-enhance-Infections', 'MTOR-reduce-Infections', 'Sarcopenia-use-IGF1', 'Neoplasms-block-NFKB1', 'APOE-confirmed-Agnosia', 'CHARGE Syndrome-affected-RTEL1', 'KL-suppress-Alzheimer Disease', 'Primary Ovarian Insufficiency-carry-FMR1', 'PIK3CA-found-Neoplasms', 'PIK3CA-identified-Neoplasms', 'PIK3CA-indicate-Neoplasms', 'NFE2L2-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-NFE2L2', 'NFE2L2-targeted-Cardiovascular Diseases', 'ECM1-inherit-Skin Diseases', 'FAM13A-associated-Lung Neoplasms', 'Lung Neoplasms-associated-FAM13A', 'FAM13A-base-Neoplasms', 'INS-compare-Hypoglycemia', 'INS-contribute-Hyperglycemia', 'FKBP4-enhance-Glioblastoma', 'Heart Failure-act-MME', 'FANCC-act-Neoplasms', 'NOX4-mediate-Idiopathic Pulmonary Fibrosis', 'AMH-reflect-Pulmonary Atresia', 'Insulin Resistance-act-INS', 'CISD2-reveal-Diabetes Mellitus', 'ASGR1-inhibit-Carcinoma, Hepatocellular', 'INS-investigate-Diabetes Mellitus', 'INSL3-assess-Hypothalamic Neoplasms', 'ITGB4-downregulated-Asthma', 'AKR1B1-address-Diabetes Mellitus', 'SIRT1-protect-Emphysema', 'Osteogenesis Imperfecta-promote-LPL', 'MB-determined-Ischemia', 'PYY-involved-Obesity', 'Ovarian Diseases-related-AMH', 'CD4-control-Viremia', 'LMNA-result-Progeria', 'FAHD1-implicated-Mitochondrial Diseases', 'CREBBP-observed-Cockayne Syndrome', 'Mitochondrial Diseases-cause-INS', 'Diabetes Mellitus-provide-INS', 'BDNF-fluctuate-Alzheimer Disease', 'BDNF-vary-Alzheimer Disease', 'BDNF-serve-Alzheimer Disease', 'DDX41-characterize-Leukemia, Myeloid, Acute', 'BACE1-investigate-Alzheimer Disease', 'Alzheimer Disease-show-SHBG', 'SHBG-prevent-Dementia', 'GBA-counteract-Brain Diseases', 'BGLAP-measured-Hypothyroidism', 'Alzheimer Disease-affect-PIN1', 'MAPT-offer-Alzheimer Disease', 'SLC1A2-reduced-Alzheimer Disease', 'Alzheimer Disease-protect-APOE', 'CLU-identified-Blindness', 'SLC1A2-result-Memory Disorders', 'SLC1A2-show-Alzheimer Disease', 'Erythema-target-COL17A1', 'NDRG2-linked-Alzheimer Disease', 'INS-increase-Metabolic Diseases', 'Neoplasms-related-NF2', 'NF2-related-Neoplasms', 'LMNB1-suggest-Neoplasms', 'MAPT-display-Tauopathies', 'GGH-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-GGH', 'GGH-increase-Cardiovascular Diseases', 'Alzheimer Disease-correlate-ADAM10', 'Pancreatitis-achieve-INS', 'GSR-associated-Periodontal Diseases', 'Periodontal Diseases-associated-GSR', 'WNT3A-expressed-Coronary Artery Disease', 'Protoporphyria, Erythropoietic-up-regulated-FECH', 'Alzheimer Disease-show-GRIN3A', 'RARRES2-played-Neurodegenerative Diseases', 'MME-prolong-Alzheimer Disease', 'ABCB1-needed-Neoplasms', 'BCAT1-repress-Breast Neoplasms', 'Breast Neoplasms-knock-BCAT1', 'CRP-involved-Colitis, Ischemic', 'CRP-combined-Colitis, Ischemic', 'Nervous System Diseases-control-INS', 'FMN2-deregulated-Alzheimer Disease', 'SIRT3-improve-Coronary Artery Disease', 'KL-associated-Cerebrovascular Disorders', 'Cerebrovascular Disorders-associated-KL', 'KL-predict-Cerebrovascular Disorders', 'INS-avoid-Hypoglycemia', 'GRIN2B-correlated-Memory Disorders', 'APOE-associated-Craniocerebral Trauma', 'Craniocerebral Trauma-associated-APOE', 'APOE-refine-Alzheimer Disease', 'Choroiditis-comprised-ELN', 'SORL1-found-Alzheimer Disease', 'EPHA2-associated-Cataract', 'Cataract-associated-EPHA2', 'STAT3-counteract-Inflammation', 'BDNF-contribute-Atrophy', 'AMH-used-Polycystic Ovary Syndrome', 'AMH-diagnose-Polycystic Ovary Syndrome', 'BDNF-mediate-Memory Disorders', 'KL-connected-Cardiovascular Diseases', 'INS-control-Obesity', 'ACE-lead-Hypertension', 'SIRT1-involved-Dementia', 'TP53-mutated-Neoplasms', 'BGLAP-reflect-Bone Diseases', 'Alzheimer Disease-implicated-CLU', 'VCP-use-Central Nervous System Diseases', 'Kidney Diseases-determined-FXYD1', 'ACE-reduce-Pneumonia', 'CD8A-activate-Amnesia', 'Parkinson Disease-foster-NOS2', 'ADCYAP1-protect-Neurotoxicity Syndromes', 'NFE2L2-defend-Heart Failure', 'CD7-become-Neoplasms', 'Neoplasms-observed-CD7', 'CST3-affect-Blood Platelet Disorders', 'EEF1E1-shown-Neoplasms', 'EEF1E1-involved-Neoplasms', 'EEF1E1-act-Neoplasms', 'MDH1-reduced-Parkinson Disease', 'TSG101-expressed-Breast Neoplasms', 'TSG101-upregulated-Neoplasms', 'Neoplasms-suggested-TSG101', 'APLN-augment-Heart Failure', 'Neoplasms-expose-MRC2', 'TRD-identify-Leukemia', 'PTHLH-create-Osteoporosis', 'INS-achieve-Fractures, Bone', 'SIRT1-play-Neurodegenerative Diseases', 'SIRT1-represent-Central Nervous System Diseases', 'APOE-contribute-Alzheimer Disease', 'Alzheimer Disease-inhibit-ACHE', 'RAN-expressed-Neoplasms', 'Heart Failure-divided-XDH', 'XDH-complicated-Kidney Diseases', 'XDH-associated-Heart Failure', 'Heart Failure-associated-XDH', 'ACE2-involved-Infections', 'CCK-identify-Diabetes Mellitus', 'ALB-assessed-Heart Failure', 'PIN1-shown-Alzheimer Disease', 'PIN1-overexpressed-Neoplasms', 'SUV39H1-involve-Neoplasms', 'PIN1-inactivate-Neoplasms', 'CST3-remain-Inflammation', 'VEGFA-implicated-Ocular Hypertension', 'SIRT6-control-Glucose Metabolism Disorders', 'RORA-influence-Drug Hypersensitivity', 'ATR-release-Heart Arrest', 'Lung Neoplasms-suffer-GH1', 'PNPLA6-induce-Nervous System Diseases', 'PON1-determine-Neurotoxicity Syndromes', 'DMD-encode-Muscular Dystrophy, Duchenne', 'Heart Arrest-trigger-MTOR', 'MAPT-mediate-Drug-Related Side Effects and Adverse Reactions', 'GGH-reduced-Alzheimer Disease', 'Atherosclerosis-purified-PLA2G1B', 'CAMK2B-suppress-Muscular Atrophy', 'Inflammation-suppress-TSLP', 'IAPP-play-Diabetes Mellitus, Type 2', 'LCN2-associated-Death', 'Death-associated-LCN2', 'Cardiovascular Diseases-associated-LCN2', 'LCN2-associated-Cardiovascular Diseases', 'Osteogenesis Imperfecta-show-BGLAP', 'Glucose Metabolism Disorders-reduce-INS', 'FGF4-amplified-Neoplasms', 'CXCL8-associated-Sarcopenia', 'Sarcopenia-associated-CXCL8', 'Neoplasms-link-FGF4', 'Alzheimer Disease-exhibit-MAPT', 'LCN2-reclassify-Coronary Artery Disease', 'LCN2-associated-Coronary Artery Disease', 'Coronary Artery Disease-associated-LCN2', 'Alzheimer Disease-find-SLC1A3', 'Death-show-ACE2', 'Alzheimer Disease-show-INS', 'CCR5-play-HIV Infections', 'ADA-use-Genetic Diseases, Inborn', 'ADA-transduce-Genetic Diseases, Inborn', 'Osteoarthritis-find-TGFA', 'Osteoarthritis-show-ACVRL1', 'TP53-form-Neoplasms', 'Death-increase-CST3', 'Kidney Diseases-use-CST3', 'CP-undergo-Neurodegenerative Diseases', 'CDKN2A-assess-Drug-Related Side Effects and Adverse Reactions', 'SIRT1-counteract-Diabetes Mellitus', 'Alzheimer Disease-show-SYP', 'Alzheimer Disease-calculated-TTR', 'Alzheimer Disease-use-TTR', 'TTR-convert-Alzheimer Disease', 'SIRT1-underlie-Wallerian Degeneration', 'APOE-accumulate-Alzheimer Disease', 'ATP6AP2-elicit-Kidney Diseases', 'APOE-surrounded-Plaque, Amyloid', 'Hypertension-present-ACHE', 'MBP-used-Nerve Degeneration', 'SIRT1-linked-Neoplasms', 'PBX3-inhibit-Leukemia, Myeloid, Acute', 'Pneumonia-associated-CRP', 'CRP-associated-Pneumonia', 'Alzheimer Disease-contribute-ADAM10', 'ADAM10-suggested-Alzheimer Disease', 'Progeria-enhance-SRSF5', 'SHBG-show-Obesity', 'FOXM1-seen-Neoplasms', 'FOXM1-insure-Aneuploidy', 'Hypertension-respond-ACE', 'FOXM1-contribute-Neoplasms', 'Heart Failure-introduced-ACE', 'MARCO-neutralize-Osteolysis', 'Obesity-perform-INS', 'NAMPT-overexpressed-Neoplasms', 'CYP19A1-used-Breast Neoplasms, Male', 'CYP19A1-treat-Breast Neoplasms, Male', 'CCN3-used-Chondrosarcoma', 'TSC22D1-identify-Carcinoma, Non-Small-Cell Lung', 'LOX-result-Diabetes Mellitus', 'LOX-impair-Diabetes Mellitus', 'Diabetes Mellitus-show-LOX', 'EPO-associated-Anemia', 'Anemia-associated-EPO', 'WRN-categorized-Werner Syndrome', 'SIRT1-improve-Cardiovascular Diseases', 'AGER-play-Diabetes Mellitus', 'IGFBP2-regulate-Metabolic Diseases', 'Insulinoma-quantify-INS', 'Alzheimer Disease-measure-APOE', 'CDKN1A-lost-Colorectal Neoplasms', 'KL-down-regulated-Acute Kidney Injury', 'PCMT1-contribute-Heredodegenerative Disorders, Nervous System', 'EPO-assessed-Hypoxia', 'ALB-found-Osteoarthritis', 'SIRT1-occluded-Atherosclerosis', 'SIRT1-upregulated-Neoplasms', 'IGF1-link-Neurodegenerative Diseases', 'GLO1-found-Neoplasms', 'DNMT3B-associated-Neoplasms', 'Neoplasms-associated-DNMT3B', 'ACVRL1-compare-Neoplasms', 'SERPINA6-associated-Osteoporosis', 'Osteoporosis-associated-SERPINA6', 'Blood Platelet Disorders-associated-CYP2C19', 'CYP2C19-associated-Blood Platelet Disorders', 'SOD1-used-Neurodegenerative Diseases', 'CCN2-promote-Liver Cirrhosis', 'Infections-influence-CD4', 'EREG-provided-Obesity', 'RELN-contribute-Alzheimer Disease', 'RELN-related-Varicose Ulcer', 'DDIT3-prevent-Death', 'Death-found-CEACAM3', 'Progeria-discover-LMNA', 'KLK3-sampled-Prostatic Neoplasms', 'ERBB2-associated-Breast Neoplasms', 'Breast Neoplasms-associated-ERBB2', 'MAPT-continue-Nerve Degeneration', 'Tauopathies-describe-MAPT', 'Infections-harvested-AKT1', 'PITX1-play-Osteoarthritis', 'PITX1-detected-Rheumatic Fever', 'APOB-measured-Diabetes Mellitus', 'Adenocarcinoma of Lung-correlated-CGAS', 'Xerostomia-explained-AQP3', 'MFN2-detected-Osteoarthritis', 'WRN-induce-Neoplasms', 'GPR39-modulate-Osteoarthritis', 'Laron Syndrome-result-INS', 'BPIFB4-corroborate-Drug-Related Side Effects and Adverse Reactions', 'Lipid Metabolism Disorders-improve-INS', 'INS-seem-Cardiac Output, High', 'INS-explain-Glucose Metabolism Disorders', 'INS-affect-Ventricular Fibrillation', 'Dementia-differ-LEP', 'AGER-play-Lung Diseases', 'TPP1-known-Neuronal Ceroid-Lipofuscinoses', 'CRP-increase-Neoplasms', 'Psychoses, Substance-Induced-compare-GDF15', 'NLRP3-involved-Parkinson Disease', 'GDF15-assess-Psychoses, Substance-Induced', 'ITGA7-expressed-Muscular Dystrophy, Duchenne', 'INS-fall-Hypotension', 'IAPP-contribute-Alzheimer Disease', 'Atherosclerosis-measure-IL10', 'RAD50-seem-Inflammation', 'NOTCH1-implicated-Cardiovascular Diseases', 'SIRT1-appear-Heart Diseases', 'MAPT-relate-Alzheimer Disease', 'Neoplasms-develop-TF', 'Infections-alter-IVNS1ABP', 'IVNS1ABP-modulate-Infections', 'KL-occurring-Wounds and Injuries', 'KL-localize-Muscular Diseases', 'SMAD4-function-Neoplasms', 'TERT-exhibit-Neurodegenerative Diseases', 'TERT-protect-Neurodegenerative Diseases', 'SMAD4-predict-Stomach Neoplasms', 'SNCA-cause-Parkinson Disease', 'ITGAM-bind-Neoplasms', 'ALPP-demonstrate-Osteogenesis Imperfecta', 'CRP-reveal-Memory Disorders', 'Fractures, Bone-occur-SHBG', 'NUDT1-suffer-Alzheimer Disease', 'FUS-fused-Amyotrophic Lateral Sclerosis', 'FUS-lead-Neurodegenerative Diseases', 'FUS-include-Amyotrophic Lateral Sclerosis', 'REN-determined-Hypertension', 'HMOX1-induce-Kidney Diseases', 'TMBIM6-used-Fatty Liver', 'GH1-administrated-Cleft Palate', 'CD4-observed-HIV Infections', 'LEP-associate-Heart Failure, Systolic', 'Heart Failure, Systolic-associate-LEP', 'SOD1-cause-Amyotrophic Lateral Sclerosis', 'Genetic Diseases, Inborn-make-RECQL4', 'NTRK1-investigate-Pigmentation Disorders', 'SHBG-associated-Osteoporosis', 'Osteoporosis-associated-SHBG', 'SHBG-associated-Muscular Dystrophy, Duchenne', 'Muscular Dystrophy, Duchenne-associated-SHBG', 'CRP-indicate-Appendicitis', 'TREM2-determined-Alzheimer Disease', 'Alzheimer Disease-play-MAPT', 'PARP1-upregulated-Hypertension', 'Neurodegenerative Diseases-present-EIF2AK3', 'Polycystic Ovary Syndrome-reduce-INS', 'LEP-increase-Anorexia', 'Muscular Atrophy, Spinal-defined-SMN1', 'APOE-associated-Coronavirus Infections', 'Coronavirus Infections-associated-APOE', 'LRP1-influence-Alzheimer Disease', 'GFAP-respond-Neurodegenerative Diseases', 'RB1-develop-Retinoblastoma', 'MAPT-represent-Neurodegenerative Diseases', 'ADIPOQ-possess-Glucose Metabolism Disorders', 'Heart Failure-related-CCL11', 'Heart Failure-block-CCL11', 'Prediabetic State-increase-INS', 'INS-decrease-Dementia', 'INS-increase-Dementia', 'Aneuploidy-caused-REEP4', 'CLU-regulated-Shock', 'Neurotoxicity Syndromes-arise-BCHE', 'ERCC3-utilize-Cockayne Syndrome', 'SHBG-fall-Obesity', 'IL6-upregulated-Osteoarthritis', 'Lipodystrophy-result-PPARG', 'Lipodystrophy-encode-PPARG', 'Contusions-seem-ELN', 'INS-fail-Atrophy', 'INS-prevent-Atrophy', 'INS-treat-Diabetes Mellitus', 'Alzheimer Disease-show-APOE', 'IGF1-influence-Death', 'PLCG2-protect-Neurodegenerative Diseases', 'CASR-undergo-Colorectal Neoplasms', 'Severe Combined Immunodeficiency-caused-IL2RG', 'PITX2-focus-Atrial Fibrillation', 'MBTD1-expressed-Osteosarcoma', 'Inflammation-link-CRP', 'Hypertension-reduced-KNG1', 'INS-contribute-Glucose Intolerance', 'Dementia-target-PRKAA1', 'TP63-affected-Ectodermal Dysplasia', 'TP63-mutated-Ectodermal Dysplasia', 'OTX2-undergo-Heart Failure', 'Hearing Loss, Central-affected-TP63', 'GREM2-become-Tendinopathy', 'AR-play-Glucose Metabolism Disorders', 'C1QTNF3-investigate-Osteoarthritis', 'BRCA1-increase-Breast Neoplasms', 'BRCA1-linked-Breast Neoplasms', 'Breast Neoplasms-reduce-BRCA1', 'TERT-promote-Neoplasms', 'COX8A-associate-Venous Thrombosis', 'Venous Thrombosis-associate-COX8A', 'Hyperglycemia-alter-INS', 'Renal Insufficiency, Chronic-develop-INS', 'Werner Syndrome-mapped-WRN', 'MTOR-result-Proteostasis Deficiencies', 'BMP2-associated-Osteoporosis', 'Osteoporosis-associated-BMP2', 'POMC-investigated-Breast Neoplasms', 'FDXR-modulate-Neoplasms', 'FDXR-play-Neoplasms', 'FDXR-required-Neoplasms', 'ACE-induce-Hypertrophy', 'AMH-correlate-Polycystic Ovary Syndrome', 'AMH-suggest-Ovarian Diseases', 'GGH-used-Muscular Atrophy', 'GGH-increase-Muscular Atrophy', 'Hypertension-found-NOS2', 'Death-result-ATM', 'XPA-arise-Genetic Diseases, Inborn', 'CDKN2A-appear-Blister', 'SRSF3-prevent-Neoplasms', 'NELFCD-linked-Infections', 'Alzheimer Disease-receive-NGF', 'NGF-promote-Alzheimer Disease', 'NGF-use-Alzheimer Disease', 'NGF-obtained-Alzheimer Disease', 'NFE2L2-related-Ovarian Diseases', 'WRN-derived-Werner Syndrome', 'Dementia, Vascular-show-VWF', 'INS-matched-Fat Necrosis', 'Tooth Attrition-compounded-SMAD3', 'Multiple Acyl Coenzyme A Dehydrogenase Deficiency-code-ETHE1', 'KLK3-exclude-Prostatic Neoplasms', 'LRP1-reduce-Parkinson Disease', 'SIRT1-observed-Prostatitis', 'SIRT1-shown-Neoplasms', 'PARK7-identified-Parkinson Disease', 'BRD4-alter-Infections', 'BRD4-isolated-Infections', 'BRD4-recruit-Infections', 'BRD4-regulate-Inflammation', 'FTO-facilitate-Weight Gain', 'WRN-encode-Werner Syndrome', 'Facial Dermatoses-reported-ELN', 'ING2-study-Iatrogenic Disease', 'NLRP3-show-Atrophy', 'SFTPC-regulate-Inflammation', 'EGFR-expressed-Neoplasms', 'Drug-Related Side Effects and Adverse Reactions-related-EGFR', 'EGFR-represent-Neoplasms', 'Drug-Related Side Effects and Adverse Reactions-target-EGFR', 'SIRT1-associated-Obesity', 'Obesity-associated-SIRT1', 'MDM4-isolated-Idiopathic Pulmonary Fibrosis', 'Dwarfism, Pituitary-combined-GGH', 'Alzheimer Disease-altered-APOE', 'CDK5-associated-Neuroblastoma', 'Neuroblastoma-associated-CDK5', 'CDK5-play-Neuroblastoma', 'CDK5-exert-Nerve Degeneration', 'MAPT-prevent-Nerve Degeneration', 'ILDR1-hear-Hearing Loss', 'Death-induced-HGF', 'Neurodegenerative Diseases-contain-TH', 'PTEN-mutated-Neoplasms', 'MSTN-emerge-Muscular Atrophy', 'Obesity-targeted-INS', 'PRDM1-promote-Neoplasms', 'PRDM1-enable-Neoplasms', 'SCN8A-associated-Seizures', 'Seizures-associated-SCN8A', 'Thyroiditis, Autoimmune-affected-AMH', 'TGFA-trigger-Neurologic Manifestations', 'Alzheimer Disease-prevent-AR', 'Parkinson Disease-characterized-MAPT', 'Huntington Disease-show-MAPT', 'Diabetes Mellitus-undergo-INS', 'SIRT1-attenuate-Neoplasms', 'Microsatellite Instability-show-TP53', 'APOE-recognized-Alzheimer Disease', 'EPO-oppose-Anemia', 'MDM2-reduce-Neoplasms', 'Fibrosis-mediate-SPARC', 'Heart Failure-suppressed-REN', 'TRPV1-place-Pain', 'REN-associated-Hypertension', 'Hypertension-associated-REN', 'CRP-associated-Hypotension', 'Hypotension-associated-CRP', 'NGFR-increased-Alzheimer Disease', 'Lipoma-lack-WRN', 'SIRT1-associated-Pulmonary Disease, Chronic Obstructive', 'Pulmonary Disease, Chronic Obstructive-associated-SIRT1', 'EGF-stimulate-Corneal Diseases', 'EGF-increase-Corneal Dystrophies, Hereditary', 'Inflammation-improve-BDNF', 'Death-differ-INS', 'Death-treated-INS', 'Neoplasms-correlate-EREG', 'RECQL-result-Glioblastoma', 'INS-cause-Diabetes Mellitus', 'SOST-increased-Renal Insufficiency, Chronic', 'SOST-exert-Calcinosis', 'Adenoma-express-PTHLH', 'PTHLH-express-Adenoma', 'PTHLH-regulate-Parathyroid Neoplasms', 'PTEN-identified-Neoplasms', 'Ovarian Diseases-used-AMH', 'ESR1-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-ESR1', 'Diabetes Mellitus, Type 2-increased-RARRES2', 'Immunologic Deficiency Syndromes-judge-TKT', 'KL-interact-Pain', 'APOE-consider-Death', 'Muscular Atrophy-require-ATF4', 'SLC26A9-expressed-Cystic Fibrosis', 'NUP153-propose-Neoplasms', 'SOD1-investigate-Disorders of Sex Development', 'SERPINF1-downregulated-Cataract', 'Chronic Traumatic Encephalopathy-associated-MAPT', 'MAPT-associated-Chronic Traumatic Encephalopathy', 'Inflammation-determined-MPO', 'Inflammation-measure-MPO', 'Colitis, Ulcerative-report-TNF', 'BDNF-involved-Hypothalamic Neoplasms', 'CRP-combined-Asthma', 'Hip Fractures-correlate-PTH', 'TARDBP-cause-Amyotrophic Lateral Sclerosis', 'ALB-correlated-Hip Fractures', 'Myocardial Infarction-dispense-PTGS2', 'Drug-Related Side Effects and Adverse Reactions-correlate-KL', 'Death-reduce-MTOR', 'KL-implicated-Renal Insufficiency, Chronic', 'ECSIT-link-Inflammation', 'CXCR4-reflect-HIV Infections', 'INS-related-Hyperinsulinism', 'Hypotension-assessed-IGFBP7', 'Hypotension-perform-INS', 'SHBG-associate-Hypogonadism', 'Hypogonadism-associate-SHBG', 'APOE-found-Joint Dislocations', 'Aneurysm-survive-TOMM40', 'Progeria-associated-INS', 'INS-associated-Progeria', 'RORC-studied-Neoplasms', 'KLK8-emerge-Alzheimer Disease', 'MAPT-result-Cerebral Amyloid Angiopathy', 'MAPT-hyperphosphorylate-Cerebral Amyloid Angiopathy', 'CTLA4-prevent-Death', 'PRL-develop-Prostatic Diseases', 'PRL-determinate-Prostatic Diseases', 'CYP2B6-impact-Epilepsy, Post-Traumatic', 'Alzheimer Disease-linked-SRC', 'Fibrosis-related-INS', 'Neoplasms-abrogated-TP53', 'SELENON-cause-Muscular Diseases', 'SELENON-associated-Genetic Diseases, Inborn', 'Genetic Diseases, Inborn-associated-SELENON', 'Nerve Degeneration-lead-NRG1', 'CYBB-observed-Inflammation', 'MTOR-increase-Tauopathies', 'Neoplasms-identified-MMRN1', 'AMH-manipulate-Ovarian Diseases', 'AMH-represent-Ovarian Diseases', 'Ovarian Diseases-involved-AMH', 'PTH-associated-Sarcopenia', 'Sarcopenia-associated-PTH', 'MAPT-focused-Alzheimer Disease', 'Kidney Diseases-used-MAPT', 'Kidney Diseases-evaluate-MAPT', 'NKX2-5-implicated-Heart Septal Defects, Atrial', 'FUS-related-Neurodegenerative Diseases', 'Neoplasms-retrogress-BMI1', 'APBB1-protect-Alzheimer Disease', 'FOXN1-implicated-Neoplasms', 'POMC-involve-Gout', 'PTH-associated-Hypertension', 'Hypertension-associated-PTH', 'TTN-implicated-Heart Failure, Diastolic', 'NOS1-show-Alzheimer Disease', 'HGF-decrease-Periodontitis', 'TERT-increase-Neoplasms', 'BSG-identify-Cerebral Infarction', 'BSG-correlate-Stroke', 'PPM1D-amplified-Neoplasms', 'AFP-produced-Carcinoma, Hepatocellular', 'CD8A-investigate-Infections', 'Infections-characterized-CD8A', 'RGS10-associated-Macular Degeneration', 'Macular Degeneration-associated-RGS10', 'Obesity-compare-SHBG', 'PARK7-implicated-Parkinson Disease', 'NR3C1-influence-Addison Disease', 'IFITM3-upregulated-Alzheimer Disease', 'IFITM3-affect-Inflammation', 'IFITM3-increased-Alzheimer Disease', 'SATB1-associated-Parkinson Disease', 'Parkinson Disease-associated-SATB1', 'CDK6-result-Neoplasms', 'HDC-involve-Alzheimer Disease', 'HP1BP3-recapitulate-Memory Disorders', 'CRH-increase-Sleep Wake Disorders', 'INS-play-Neurotoxicity Syndromes', 'CST3-compared-Kidney Diseases', 'PRPH2-associated-Macular Degeneration', 'Macular Degeneration-associated-PRPH2', 'VIP-related-Heart Failure', 'MAPT-characterized-Alzheimer Disease', 'Cataract-associated-MSRA', 'MSRA-associated-Cataract', 'CD4-retained-Infections', 'Werner Syndrome-protected-CAT', 'BDNF-increase-Alzheimer Disease', 'MAPT-take-Alzheimer Disease', 'FOXO1-inhibit-Heart Arrest', 'Cardiac Output, Low-correlate-CS', 'RELN-associated-Brain Diseases', 'Brain Diseases-associated-RELN', 'AHNAK-associated-Seizures', 'Seizures-associated-AHNAK', 'CHGA-separate-Alzheimer Disease', 'Infections-downregulate-TLR4', 'TLR4-depend-Infections', 'SIRT7-found-Ovarian Neoplasms', 'Neurodegenerative Diseases-applied-TARDBP', 'Neurodegenerative Diseases-assess-TARDBP', 'Death-associated-TARDBP', 'TARDBP-associated-Death', 'WRN-mediate-Werner Syndrome', 'WRN-modulate-Atherosclerosis', 'Cockayne Syndrome-contain-ERCC6', 'Hyperinsulinism-involve-MTOR', 'CST3-measure-Cardiovascular Diseases', 'CST3-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-CST3', 'SLC2A9-observed-Neoplasms', 'GPT-predict-Gallstones', 'FANCA-implicated-Primary Ovarian Insufficiency', 'CFH-accumulate-Glycogen Storage Disease Type II', 'SOX4-endow-Neoplasms', 'Uremia-affect-KL', 'KL-decrease-Uremia', 'KL-inhibit-Uremia', 'BACE1-predispose-Alzheimer Disease', 'Fatty Liver-reduce-CYP2C19', 'EIF3A-disrupted-Neoplasms', 'EIF3A-orchestrate-Neoplasms', 'CETP-offer-Coronary Artery Disease', 'PMP22-include-Shock', 'APOE-show-Sleep Apnea, Obstructive', 'INS-appear-Diabetes Mellitus', 'Inflammation-demonstrated-CRP', 'TSTD1-activate-Sleep Initiation and Maintenance Disorders', 'AMH-constitute-Ovarian Diseases', 'HDAC6-upregulated-Leukemia, Lymphocytic, Chronic, B-Cell', 'Polycystic Ovary Syndrome-reflect-AMH', 'KL-decreased-Lung Neoplasms', 'KL-identify-Neoplasms', 'KL-overexpressed-Neoplasms', 'KL-inhibit-Lung Neoplasms', 'ALB-identified-Anemia', 'SIRT3-implicated-Carcinogenesis', 'ACE-tolerate-Hypertension', 'SIRT3-decreased-Carcinoma, Hepatocellular', 'Diabetes Mellitus, Type 2-characterized-ADIPOQ', 'RHOA-contain-Infections', 'CD5-affect-Paraproteinemias', 'Inflammation-contribute-CDKN2A', 'Hypoxia-include-MAPT', 'GDNF-prevent-Parkinson Disease', 'CALCA-play-Osteoporosis', 'CRP-correlate-Skin Diseases', 'INS-accompanied-Hyperlipidemias', 'Alzheimer Disease-shown-APOE', 'CIAO2B-promote-Osteosarcoma', 'Neoplasms-found-IGF2', 'DICER1-render-Drug Hypersensitivity', 'PTK2B-protected-Death', 'TNF-associated-Pneumonia', 'Pneumonia-associated-TNF', 'Anemia-raise-CRP', 'AMH-observed-Hypertension', 'ACE2-reduced-Asthma', 'CLU-found-Adenoma', 'CLU-investigate-Pituitary Neoplasms', 'CLU-found-Pituitary Neoplasms', 'EXO1-correlate-Neoplasms', 'Amyloidosis-characterized-TTR', 'TTR-contribute-Fibrosis', 'BDNF-related-Memory Disorders', 'Disseminated Intravascular Coagulation-use-THBD', 'MAPT-induced-Memory Disorders', 'MAPT-potentiate-Memory Disorders', 'Carcinogenesis-mediate-INS', 'Rothmund-Thomson Syndrome-accumulate-XRCC1', 'FLCN-described-Pneumothorax', 'PCSK6-use-Ovarian Neoplasms', 'PPARG-reduce-Inflammation', 'TP53-regulate-Heart Arrest', 'APOE-lead-Alzheimer Disease', 'GGH-associate-Cardiovascular Diseases', 'Cardiovascular Diseases-associate-GGH', 'Cardiovascular Diseases-include-SHMT1', 'Parkinson Disease-derived-GBA', 'SIRT6-involved-Inflammation', 'SIRT6-involved-Diabetes Mellitus', 'Fibrosis-produced-JAK2', 'Amyotrophic Lateral Sclerosis-form-TARDBP', 'Amyotrophic Lateral Sclerosis-encoded-TARDBP', 'Sclerosis-associated-APOE', 'APOE-associated-Sclerosis', 'CDC42-decreased-Tangier Disease', 'Intellectual Disability-improve-POMC', 'Mitochondrial Diseases-include-MAPT', 'CXCR4-delete-Osteosarcoma', 'Fibrosis-accompanied-ELN', 'Neoplasms-reported-SIRT3', 'LCN2-proven-Renal Insufficiency, Chronic', 'Death-diagnosed-CD4', 'Cockayne Syndrome-thought-ERCC6', 'CFTR-influence-Insulin Resistance', 'ERCC6-played-Aging, Premature', 'IL2-respond-Drug-Related Side Effects and Adverse Reactions', 'EPO-remain-Hypoxia', 'EPO-treat-Anemia', 'EPO-assessed-Anemia', 'EPO-develop-Anemia', 'GDF5-implicate-Osteoarthritis', 'GDF5-involved-Osteoarthritis', 'Urinary Bladder Neoplasms-involve-TERT', 'TERT-involved-Neoplasms', 'BAP1-contribute-Urinary Bladder Neoplasms', 'HRAS-cause-Neoplasms', 'SIRT1-promote-Alzheimer Disease', 'TENT4B-restore-Dyskeratosis Congenita', 'PLEKHO1-target-Osteoporosis', 'PLEKHO1-reverse-Osteoporosis', 'PRL-associated-Hypertension', 'Hypertension-associated-PRL', 'ELN-associated-Facial Dermatoses', 'Facial Dermatoses-associated-ELN', 'ELN-result-Facial Dermatoses', 'IFNA1-administered-Liver Cirrhosis', 'CRP-taken-Inflammation', 'NPY-delay-Progeria', 'NPY-rescue-Progeria', 'NPY-increase-Hypothalamic Neoplasms', 'FOXP3-cause-Azoospermia', 'NPY-increase-Progeria', 'FOXP3-expressed-Azoospermia', 'SORL1-accelerate-Memory Disorders', 'Aortic Aneurysm, Abdominal-found-TLR3', 'RAP1A-exposed-Multiple Chronic Conditions', 'SIRT6-lack-Alzheimer Disease', 'SIRT6-related-Alzheimer Disease', 'TREM2-cause-Alzheimer Disease', 'TREM2-stopp-Alzheimer Disease', 'Drug-Related Side Effects and Adverse Reactions-sensitize-ACKR3', 'UCP1-associated-Obesity', 'Obesity-associated-UCP1', 'VEGFA-induce-Hypoxia', 'CRP-derived-Cardiovascular Diseases', 'Ovarian Diseases-increase-ESR1', 'Osteoarthritis-derived-TTR', 'Hypertension-decrease-ACE', 'RYR2-associated-Adenocarcinoma of Lung', 'Adenocarcinoma of Lung-associated-RYR2', 'Neoplasms-evaluated-EGFR', 'TNF-related-Heart Failure', 'NR1H4-alleviate-Liver Diseases', 'INS-demonstrated-Obesity', 'SNCA-result-Parkinson Disease', 'SNCA-underly-Parkinson Disease', 'FGF21-mediate-Glucose Metabolism Disorders', 'FGF21-regulate-Glucose Metabolism Disorders', 'INS-worsen-Retinal Diseases', 'BCL2-approved-Leukemia, Myeloid, Acute', 'NFE2L2-represent-Osteoarthritis', 'PTH-decrease-Fractures, Bone', 'VWF-associated-Aneurysm', 'Aneurysm-associated-VWF', 'Parkinson Disease-target-HSPA5', 'NPC1L1-associated-Coronary Artery Disease', 'Coronary Artery Disease-associated-NPC1L1', 'LEP-elevated-Heart Failure', 'Alzheimer Disease-provide-APOE', 'ACE2-cause-Inflammation', 'INS-develop-Hyperplasia', 'METTL3-up-regulated-Diabetes Mellitus, Type 2', 'Heart Arrest-maintain-KL', 'Kidney Diseases-decrease-KL', 'PML-promote-Progeria', 'Alzheimer Disease-prevent-MAPT', 'CHAT-expressed-Alzheimer Disease', 'Atrioventricular Block-elevate-ALB', 'AMH-correlated-Ovarian Diseases', 'CHI3L1-associated-Encephalitis', 'Encephalitis-associated-CHI3L1', 'PDCD10-predispose-Abnormalities, Drug-Induced', 'Hypertension-harbour-SLC12A3', 'USP22-treat-Retinoblastoma', 'USP22-facilitate-Retinoblastoma', 'APOE-contribute-Glucose Metabolism Disorders', 'Alzheimer Disease-increased-GFAP', 'Progeria-arise-LMNA', 'Alzheimer Disease-comprised-MAPT', 'IL6-coupled-Death', 'MAPT-investigate-Alzheimer Disease', 'APOE-used-Vascular Calcification', 'Heart Failure-present-ACE', 'ALB-measured-Albuminuria', 'Metabolic Syndrome-increase-RETN', 'Parkinson Disease-divided-PRKN', 'Parkinson Disease-involved-PRKN', 'Dementia, Vascular-found-KL', 'BCL2-associated-Ulcer', 'Ulcer-associated-BCL2', 'BCL2-associated-Melanoma', 'Melanoma-associated-BCL2', 'TTR-result-Amyloidosis, Familial', 'TTR-result-Multiple Myeloma', 'NPEPPS-lead-Prostatic Neoplasms', 'Prostatic Neoplasms-based-NPEPPS', 'Sarcopenia-observed-IGF1', 'ADCYAP1-exert-Dry Eye Syndromes', 'VEGFA-remain-Heart Failure', 'SIRT1-implicated-Glucose Metabolism Disorders', 'Neoplasms-increased-CYP3A4', 'CAT-treat-Inflammation', 'Werner Syndrome-complement-WRN', 'Adenocarcinoma of Lung-correlated-TP53', 'HBA1-correlate-Diabetes Mellitus', 'ZNF410-associated-Alzheimer Disease', 'Alzheimer Disease-associated-ZNF410', 'SIRT1-discuss-Aneurysm', 'CST3-increased-Death', 'CST3-combined-Death', 'LMNA-play-Bone Neoplasms', 'SIRT6-prevent-Bone Neoplasms', 'Glucose Metabolism Disorders-quantitate-INS', 'Arthritis, Rheumatoid-show-CRP', 'SIRT6-attenuate-Osteoporosis', 'Fibrosis-arise-TGFA', 'CRP-associated-Arthritis, Rheumatoid', 'Arthritis, Rheumatoid-associated-CRP', 'CD4-render-HIV Infections', 'CNTF-cause-Weight Loss', 'ERCC6-overexpressed-Neoplasms', 'ERCC6-presented-Neoplasms', 'TOLLIP-associated-Amyotrophic Lateral Sclerosis', 'Amyotrophic Lateral Sclerosis-associated-TOLLIP', 'EGFR-help-Lung Neoplasms', 'ANXA6-serve-Vascular Calcification', 'Lung Neoplasms-include-EGFR', 'CRP-increase-Stroke', 'Hypothalamic Diseases-operate-GGH', 'GHR-assess-Glucose Metabolism Disorders', 'GHR-present-Growth Disorders', 'INS-alter-Glucose Metabolism Disorders', 'ACE-reduce-Proteinuria', 'Alzheimer Disease-reduced-ADAM10', 'Hypogonadism-defined-GH1', 'SCPEP1-triage-Death', 'CRP-exacerbate-Atherosclerosis', 'Blood Platelet Disorders-measure-Arachidonic Acid', 'Inflammation-caused-Lipopolysaccharides', 'Alzheimer Disease-associated-rs2910164', 'rs2910164-associated-Alzheimer Disease', 'Alzheimer Disease-found-rs2910164', 'RN7SK-downregulated-Neoplasms', 'MIR126-associated-Diabetic Nephropathies', 'Diabetic Nephropathies-associated-MIR126', 'H19-used-Sarcopenia', 'CCDC26-decrease-Metabolic Syndrome', 'CCDC26-evaluate-Metabolic Syndrome', 'Carcinogenesis-suggest-MT-TG', 'HOTAIR-predict-Neoplasms', 'CDKN2B-AS1-inhibit-Heart Arrest', 'SNHG1-used-Glioma', 'SNHG1-function-Neoplasms', 'SNHG1-measured-Glioma', 'SNHG1-function-Glioma', 'SNHG1-expressed-Glioma', 'NORAD-result-Mitochondrial Diseases', 'MIR34A-highlight-Pulmonary Disease, Chronic Obstructive', 'MIR133B-implicated-Parkinson Disease', 'PWRN2-aggravate-Mitochondrial Diseases', 'MIR126-associated-Coronary Artery Disease', 'Coronary Artery Disease-associated-MIR126', 'PTCSC3-separate-Osteoporosis', 'PTCSC3-increase-Osteoporosis', 'MIR377-include-Heart Arrest', 'MIR200B-include-Heart Arrest', 'PVT1-participate-Neoplasms', 'VTRNA2-1-suppress-Neoplasms', 'H19-seem-Sarcopenia', 'Sarcopenia-use-H19', 'H19-classify-Sarcopenia', 'MIAT-up-regulated-Cataract', 'MIAT-repress-Necrosis', 'MIR143-fail-Heart Arrest', 'H19-corrected-Sarcopenia', 'H19-use-Drug Resistant Epilepsy', 'MIR184-result-Retinal Degeneration', 'MIR146A-associated-Alzheimer Disease', 'Alzheimer Disease-associated-MIR146A', 'HOTAIR-attenuate-Vascular Calcification', 'BCYRN1-accompanied-Keratitis, Dendritic', 'BCYRN1-up-regulated-Alzheimer Disease', 'BCYRN1-increase-Alzheimer Disease', 'MT-TG-associated-LEOPARD Syndrome', 'LEOPARD Syndrome-associated-MT-TG', 'H19-improve-Sarcopenia', 'Intracranial Hemorrhage, Hypertensive-managed-LINC02605', 'Hematoma-increase-LINC02605', 'Death-monitored-PWRN2', 'FBXW7-AS1-associated-Hypertension', 'Hypertension-associated-FBXW7-AS1', 'MIR10A-result-Osteosarcoma', 'TERC-influence-Alzheimer Disease', 'H19-use-Sarcopenia', 'Sarcopenia-classified-H19', 'KCNQ1OT1-mediate-Neoplasms', 'Ataxia-calculated-H19', 'MIR21-involved-Atrial Fibrillation', 'MIR34A-reduce-Calcinosis', 'MIR221-investigated-Heart Failure', 'Glucose-implicated-Diabetes Mellitus, Type 2', 'Fatty Acids-implicated-Diabetes Mellitus, Type 2', 'Glucose-act-Death', 'Triglycerides-act-Death', 'Glucose-rely-Fatty Acids', 'Valproic Acid-reduce-Topiramate', 'Cholesterol-remain-Glucose', 'Ascorbic Acid-increase-Isoprostanes', 'Renal Insufficiency, Chronic-defined-Glucose', 'Glucose-associated-Renal Insufficiency, Chronic', 'Renal Insufficiency, Chronic-associated-Glucose', 'Coronary Artery Disease-associated-Glucose', 'Glucose-associated-Coronary Artery Disease', 'Cholesterol-fast-Glucose', 'Immunologic Deficiency Syndromes-associated-Glucose', 'Glucose-associated-Immunologic Deficiency Syndromes', 'Immunologic Deficiency Syndromes-associated-Cholesterol', 'Cholesterol-associated-Immunologic Deficiency Syndromes', 'Triglycerides-reduce-Cardiovascular Diseases', 'Glucose-associated-Fatty Acids', 'Fatty Acids-associated-Glucose', 'Glucose-include-Fatty Acids', 'Glucose-followed-Triglycerides', 'Cardiovascular Diseases-accompanied-Glucose', 'Cardiovascular Diseases-reduce-Cholesterol', 'Glucose Metabolism Disorders-identified-Cholesterol', 'Teichoic Acids-interact-Gangliosides', 'Pneumococcal Infections-interact-Gangliosides', 'Sugars-contain-Lipofuscin', 'Sugars-recognize-Neuronal Ceroid-Lipofuscinoses', 'Lipofuscin-contain-Neuronal Ceroid-Lipofuscinoses', 'Phospholipids-dephosphorylate-Inositol', 'Cholesterol-tend-Ascorbic Acid', 'Cholesterol-added-Ascorbic Acid', 'Glucose-predict-Atherosclerosis', 'Ascorbic Acid-contain-Lipofuscin', 'Ceramides-elevated-Doxorubicin', 'Glucose-base-Fatty Acids, Nonesterified', 'Glucose-protect-Diabetes Mellitus, Type 2', 'Cholesterol-protect-Diabetes Mellitus, Type 2', 'Alzheimer Disease-exceed-N-Acetylneuraminic Acid', 'Doxorubicin-known-Ceramides', 'Alzheimer Disease-exceed-Gangliosides', 'Doxorubicin-result-Ceramides', 'Glucose-altered-Metabolic Syndrome', 'Triglycerides-altered-Metabolic Syndrome', 'Butyrates-considered-Glycogen', 'Neurodegenerative Diseases-related-Cholesterol', 'Cholesterol-band-Sucrose', 'Docosahexaenoic Acids-seem-Glucose', 'Docosahexaenoic Acids-seem-Glucose Intolerance', 'Hyaluronic Acid-given-Atorvastatin', 'Ascorbic Acid-abolish-Cholesterol', 'Triglycerides-maintain-Glycogen', 'Lipofuscin-consist-Sugars', 'Oils-exhibit-Phytic Acid', 'Fructose-do-Triglycerides', 'Glucose-substitute-Anorexia', 'Glossitis-related-Ascorbic Acid', 'Glossitis-related-Cholesterol', 'Topiramate-used-Valproic Acid', 'Glucose-determined-Diabetes Mellitus', 'Glucose-utilize-Fatty Acids', 'Ascorbic Acid-contain-Fish Oils', 'Glucose-found-Cholesterol', 'Glucose-found-Hypertension', 'Ghrelin-associated-Glucose', 'Glucose-associated-Ghrelin', 'Ghrelin-correlate-Cholesterol', 'Stroke-show-Glucose', 'Stroke-show-Cholesterol', 'Phosphatidylserines-quantified-Glucose', 'Metabolic Syndrome-used-Glucose', 'Glucose-define-Metabolic Syndrome', 'Metabolic Syndrome-used-Triglycerides', 'Triglycerides-compare-Glucose', 'Diabetes Mellitus-normalize-Glucose', 'Diabetes Mellitus-reach-Cholesterol', 'Cholesterol-associated-Heart Failure', 'Heart Failure-associated-Cholesterol', 'Ascorbic Acid-function-Cholesterol', 'Cholesterol-increase-Ascorbic Acid', 'Glucose-associated-Chronic Disease', 'Chronic Disease-associated-Glucose', 'Cholesterol-associated-Chronic Disease', 'Chronic Disease-associated-Cholesterol', 'Cholesterol-include-Neomycin', 'Fatty Acids, Nonesterified-rely-Glucose', 'Fatty Acids-alter-Pentosephosphates', 'Glucose Metabolism Disorders-alter-Pentosephosphates', 'Cholesterol-exert-Glucose', 'Glycerol-reveal-Hyperinsulinism', 'Fatty Acids-reveal-Hyperinsulinism', 'Cataract-optimized-Ascorbic Acid', 'Cataract-optimized-Fatty Acids, Omega-3', 'Glucose-correlate-Obesity', 'Triglycerides-correlate-Obesity', 'Diabetes Mellitus-compare-Triglycerides', 'Saponins-used-Neoplasms', 'Saponins-manage-Neoplasms', 'Oils, Volatile-used-Neoplasms', 'Oils, Volatile-manage-Neoplasms', 'Diabetes Mellitus-include-Triglycerides', 'Cerebrovascular Disorders-assessed-Glucose', 'Cerebrovascular Disorders-measure-Glucose', 'Cerebrovascular Disorders-assessed-Cholesterol', 'Cerebrovascular Disorders-measure-Cholesterol', 'Seizures-include-Topiramate', 'Seizures-include-Valproic Acid', 'Glucose-administered-Octreotide', 'Octreotide-require-Glucose', 'Octreotide-correct-Hypoglycemia', 'Hypoglycemia-receive-Glucose', 'Hypoglycemia-receive-Octreotide', 'Glucose-receive-Octreotide', 'Octreotide-increase-Glucose', 'Octreotide-prevent-Glucose', 'Doxorubicin-administered-Lymphoma', 'Bleomycin-administered-Lymphoma', 'Glutathione Disulfide-excluded-Glucosephosphate Dehydrogenase Deficiency', 'Glucose-reduce-Ghrelin', 'Ghrelin-decreased-Glucose', 'Bleomycin-measure-Neoplasms', 'Digoxin-potentiated-Cyclosporine', 'Digoxin-potentiated-Kidney Diseases', 'Streptozocin-treated-Lisinopril', 'Diabetes Mellitus-treated-Lisinopril', 'Glucose-fell-Enalapril', 'Glycopeptides-play-N-Acetylneuraminic Acid', 'Glutathione-detoxify-Dehydroascorbic Acid', 'Ascorbic Acid-treat-Infertility, Male', 'Glutathione-treat-Infertility, Male', 'Staphylococcal Infections-found-Clindamycin', 'Staphylococcal Infections-found-Piperacillin, Tazobactam Drug Combination', 'Trimethoprim, Sulfamethoxazole Drug Combination-decrease-Aminoglycosides', 'Doxorubicin-treat-Rituximab', 'Cardiotoxicity-induced-Doxorubicin', 'Doxorubicin-treated-Trastuzumab', 'Doxorubicin-needed-Cardiotoxicity', 'Trastuzumab-needed-Cardiotoxicity', 'Infliximab-associated-Inositol 1,4,5-Trisphosphate', 'Inositol 1,4,5-Trisphosphate-associated-Infliximab', 'Lymphoma-treated-Rituximab', 'Glucose-involved-Infliximab', 'Rituximab-consist-Doxorubicin', 'Ouabain-cause-Infliximab', 'Drug-Related Side Effects and Adverse Reactions-cause-Ouabain', 'Drug-Related Side Effects and Adverse Reactions-cause-Infliximab', 'Infliximab-activated-Inositol 1,4,5-Trisphosphate', 'Rituximab-followed-Doxorubicin', 'Rituximab-confirm-Doxorubicin', 'Rituximab-treated-Doxorubicin', 'Lymphoma, B-Cell-receive-Rituximab', 'Rituximab-cure-Doxorubicin', 'Rituximab-incorporated-Anthracyclines', 'Anthracyclines-combined-Trastuzumab', 'Heart Diseases-receive-Anthracyclines', 'Lymphoma, Non-Hodgkin-receive-Doxorubicin', 'Heart Diseases-combined-Trastuzumab', 'Lymphoma, Non-Hodgkin-receive-Rituximab', 'Glucose-confirmed-Atrial Fibrillation', 'Lipopolysaccharides-confirmed-Atrial Fibrillation', 'rs28934576-enhance-Agar', 'Diabetes Mellitus-measure-Blood Glucose', 'Diabetes Mellitus, Type 2-arise-Glucose', 'Hypercalcemia-potentiate-Digoxin', 'Melkersson-Rosenthal Syndrome-placed-Inositol', 'Ascorbic Acid-include-Rosacea', 'Doxorubicin-induce-Osteosarcoma', 'Glucose-associated-Cerebrovascular Disorders', 'Cerebrovascular Disorders-associated-Glucose', 'Digoxin-treat-Atrial Fibrillation', 'Hyaluronic Acid-reach-Pain', '2,3-Diphosphoglycerate-increased-Parkinson Disease, Secondary', 'Ascorbic Acid-protect-Gallstones', 'Fondaparinux-offer-Venous Thrombosis', 'Sepsis-increased-Gentamicins', 'Gentamicins-used-Infections', 'Kidney Diseases-receive-Sucrose', 'Sucrose-associated-Nephrosis', 'Nephrosis-associated-Sucrose', 'Polysaccharides-changed-Werner Syndrome', 'Hemochromatosis-show-Glucose', 'Intestinal Diseases-affect-Glucose', 'Ascorbic Acid-inhibit-Heart Arrest', 'Lymphoma-receive-Etoposide', 'Streptozocin-induce-Alzheimer Disease', 'Infections-exposed-Canagliflozin', 'Weight Loss-represent-Canagliflozin', 'Infections-increased-Canagliflozin', 'Dithiothreitol-obtained-Diabetes Mellitus', 'Isosorbide Dinitrate-compare-Erectile Dysfunction', 'Aminoglycosides-avoid-Sepsis', 'Glucose-caused-Alzheimer Disease', 'Glucose-suggest-Wounds, Nonpenetrating', 'Etoposide-prove-Lymphoma', 'Glycogen-identified-Astrocytoma', 'Diabetes Mellitus-correlated-Sugars', 'Heparin, Low-Molecular-Weight-include-Venous Thromboembolism', 'Anthracyclines-pose-Cardiotoxicity', 'Ascorbic Acid-undergo-Pigmentation Disorders', 'Ascorbic Acid-form-Pigmentation Disorders', 'Anthracyclines-require-Cardiotoxicity', 'Heparin-used-Brugada Syndrome', 'Heparin-associated-Death', 'Death-associated-Heparin', 'Glucose-prevent-Hypertension', 'Glucose-define-Diabetes Mellitus', 'Heparitin Sulfate-fulfill-Alzheimer Disease', 'Leukemia, Myeloid, Acute-combine-Anthracyclines', 'Drug-Related Side Effects and Adverse Reactions-use-Daunorubicin', 'Cataract-oxidize-Ascorbic Acid', 'Glucose-based-Diabetes Mellitus', 'Diabetes Mellitus-recommend-Glucose', 'Keratan Sulfate-protect-Arthritis', 'Leukemia, Myelogenous, Chronic, BCR-ABL Positive-assessed-Glucose', 'Streptozocin-treat-Pancreatic Neoplasms', 'Arthritis-dictated-Keratan Sulfate', 'Infections-observe-Glycosaminoglycans', 'Alzheimer Disease-use-Glucose', 'Glucose-contribute-Metabolic Syndrome', 'Fructose-account-Cataract', 'Ribose-used-Diabetes Mellitus', 'Ascorbic Acid-prevent-Renal Insufficiency', 'Glycosaminoglycans-occur-Parkinson Disease', 'Heart Diseases-receive-Etoposide', 'Facial Dermatoses-accompany-Glycosaminoglycans', 'Aminoglycosides-used-Drug-Related Side Effects and Adverse Reactions', 'Drug-Related Side Effects and Adverse Reactions-induced-Aminoglycosides', 'Polysaccharides-range-Infections', 'Aminoglycosides-used-Endocarditis', 'Alzheimer Disease-seen-Sugars', 'Myocardial Infarction-treated-Enoxaparin', 'Diabetes Mellitus-base-Glucose', 'Enoxaparin-develop-Abducens Nerve Diseases', 'Hyaluronic Acid-stimulate-Hyperplasia', 'Acarbose-give-Glucose Metabolism Disorders', 'Drug-Related Side Effects and Adverse Reactions-range-Digoxin', 'Inositol-mirror-Alzheimer Disease', 'Inositol-seen-Alzheimer Disease', 'Heparin, Low-Molecular-Weight-prescribed-Kidney Diseases', 'Polysaccharides-protect-Pneumococcal Infections', 'Neoplasms-prescribed-Heparin, Low-Molecular-Weight', 'Ascorbic Acid-link-Cardiovascular Diseases', 'Lipodystrophy-base-Glucose', 'Lipodystrophy-proceed-Glucose', 'Amikacin-regarded-Infections', 'Diabetes Mellitus-check-Glucose', 'Diabetes Mellitus-tested-Blood Glucose', 'Kidney Diseases-calculated-Gentamicins', 'Small Cell Lung Carcinoma-emerge-Etoposide', 'Hyaluronic Acid-offer-Drug Hypersensitivity', 'Diabetes Mellitus-question-Glucose', 'Glucose-indicate-Cardiac Output, Low', 'Malnutrition-decrease-Streptomycin', 'Glucose-collected-Sepsis', 'Metabolic Syndrome-added-Glucose', 'Sugars-induced-Diabetes Mellitus', 'Uronic Acids-show-Headache', 'Ascorbic Acid-increased-Werner Syndrome', 'Glucose-include-Hypoglycemia', 'Muscular Diseases-result-Glycogen', 'Pulmonary Disease, Chronic Obstructive-decrease-Ascorbic Acid', 'Ascorbic Acid-observed-Pulmonary Disease, Chronic Obstructive', 'Chest Pain-enrolled-Glucose', 'Hyperglycemia-identify-Glucose', 'Atherosclerosis-achieve-Glucose', 'Lymphoma, Non-Hodgkin-treated-Etoposide', 'Lymphoma, Non-Hodgkin-include-Etoposide', 'Ascorbic Acid-cause-Dehydration', 'Glucose-follow-Insulin Resistance', 'Glycosaminoglycans-related-Cerebrovascular Disorders', 'Glucose-represent-Hyperglycemia', 'Hyperinsulinism-result-Glucose', 'Memory Disorders-reversed-Glucose', 'Glucose-enhance-Alzheimer Disease', 'Doxorubicin-considered-Breast Neoplasms', 'Hypoxia-determine-Glycosaminoglycans', 'Heparitin Sulfate-contribute-Osteoarthritis', 'Ascorbic Acid-associated-Cataract', 'Cataract-associated-Ascorbic Acid', 'Heparin-worsen-Hemostatic Disorders', 'Heparin-administered-Flushing', 'Digoxin-show-Drug-Related Side Effects and Adverse Reactions', 'Digoxin-found-Drug-Related Side Effects and Adverse Reactions', 'Thyrotoxicosis-increase-Digoxin', 'Sugars-modified-Diabetes Mellitus', 'Sugars-involved-Atherosclerosis', 'Heparin-established-Hemostatic Disorders', 'Amikacin-given-Febrile Neutropenia', 'Hypoglycemia-reported-Glucose', 'Hyperglycemia-monitored-Glucose', 'Glucose-impaired-Diabetes Mellitus', 'Glucose-found-Glycosuria', 'Doxorubicin-promote-Colorectal Neoplasms', 'Thrombosis-indicated-Heparin, Low-Molecular-Weight', 'Ulcer-do-Sucralfate', 'Glucose-indicate-Death', 'Leukemia-exposed-Daunorubicin', 'Gentamicins-examined-Infections', 'Diabetes Mellitus-correlated-Blood Glucose', 'Digoxin-administered-Tachycardia, Supraventricular', 'Heparin-used-Renal Insufficiency', 'Diabetes Mellitus-benefit-Glucose', 'Kidney Diseases-differ-Heparin', 'Neoplasms-calculated-Ascorbic Acid', 'Heparin-reduce-Venous Thrombosis', 'Heparin-prevent-Venous Thromboembolism', 'Digoxin-used-Drug-Related Side Effects and Adverse Reactions', 'Glucosamine-relieve-Arthritis', 'Anthracyclines-reduce-Neoplasms', 'Pancreatitis-enhance-Glucose', 'Glucose-develop-Diabetes Mellitus', 'Diabetes Mellitus-based-Glucose', 'Phytic Acid-prevent-Vascular Calcification', 'Phytic Acid-prevent-Calcinosis', 'Sepharose-displayed-Colonic Neoplasms', 'Heparin-exhibit-Infections', 'Inflammation-include-Glucose', 'Polysaccharides-associated-Metabolic Diseases', 'Metabolic Diseases-associated-Polysaccharides', 'Polysaccharides-mark-Metabolic Diseases', 'Hantavirus Pulmonary Syndrome-flow-Hyaluronic Acid', 'Femoral Neck Fractures-assigned-Gentamicins', 'Galactose-cause-Infections', 'Hypoglycemia-increase-Glucose', 'Doxorubicin-represent-Lymphoma, B-Cell', 'Glycosaminoglycans-decline-Cartilage Diseases', 'Diabetes Mellitus, Type 2-prime-Streptozocin', 'Diabetes Mellitus-stretch-Glucose', 'Anthracyclines-known-Cardiotoxicity', 'Congenital Hyperinsulinism-used-Glucose', 'Hyperinsulinism-decrease-Glucose', 'Hyperinsulinism-increase-Glucose', 'Ribose-receive-Retinal Perforations', 'Fructosamine-aid-Diabetes Mellitus', 'Fructosamine-monitor-Diabetes Mellitus', 'Fructosamine-established-Diabetes Mellitus', 'Digoxin-tolerated-Atrial Fibrillation', 'Ascorbic Acid-associated-Pulmonary Disease, Chronic Obstructive', 'Pulmonary Disease, Chronic Obstructive-associated-Ascorbic Acid', 'Alginates-suffering-Ulcer', 'Cardiovascular Diseases-include-Glucose', 'Cardiovascular Diseases-measure-Glucose', 'Hypertension-increase-Ascorbic Acid', 'Polysaccharides-express-Typhoid Fever', 'Diabetes Mellitus-emerge-Glucose', 'Glucose-diminished-Diabetes Mellitus', 'Hemolytic-Uremic Syndrome-oxidize-Ascorbic Acid', 'Diabetic Nephropathies-improve-Glucose', 'Hypoglycemia-overlooked-Glucose', 'Enoxaparin-receive-Venous Thromboembolism', 'Fractures, Bone-develop-Enoxaparin', 'Hemorrhage-occur-Enoxaparin', 'Enoxaparin-seem-Venous Thrombosis', 'Glyceraldehyde-elevated-Non-alcoholic Fatty Liver Disease', 'Ascorbic Acid-enhanced-Cataract', 'Ascorbic Acid-identify-Werner Syndrome', 'Ascorbic Acid-find-Heart Arrest', 'Glucose-studied-Congenital Hyperinsulinism', 'Osteoarthritis-included-Chondroitin Sulfates', 'Mitochondrial Diseases-induced-Doxorubicin', 'Doxorubicin-inhibited-Lung Neoplasms', 'Hyaluronic Acid-used-Immunologic Deficiency Syndromes', 'Vascular System Injuries-exacerbated-Glucose', 'Glucose-persist-Hyperglycemia', 'Blind Loop Syndrome-determined-Glucose', 'Intracranial Hemorrhages-bridge-Heparin', 'Heparin-complicated-Thrombocytopenia', 'Pulmonary Embolism-lowered-Heparin', 'Hantavirus Pulmonary Syndrome-increase-Ribose', 'Hyaluronic Acid-supposed-Neoplasms', 'Hyaluronic Acid-contribute-Neoplasms', 'Hyaluronic Acid-aimed-Pain', 'Hyaluronic Acid-decrease-Pain', 'Hyaluronic Acid-approved-Osteoarthritis', 'Thalassemia-treated-Ascorbic Acid', 'Lymphoma, Non-Hodgkin-use-Nucleosides', 'Etoposide-lessen-Drug-Related Side Effects and Adverse Reactions', 'Lymphoma, Non-Hodgkin-used-Doxorubicin', 'Canagliflozin-avoided-Fractures, Bone', 'Glucose-become-Diabetes Mellitus', 'Carcinoma, Hepatocellular-grown-Glucose', 'Diabetic Nephropathies-used-Glucose', 'Aminoglycosides-recommended-Pneumonia', 'Cystic Fibrosis-account-Aminoglycosides', 'Streptozocin-increased-Diabetes Mellitus', 'Werner Syndrome-determine-Oligosaccharides', 'Werner Syndrome-compare-Oligosaccharides', 'Ascorbic Acid-improve-Gerstmann Syndrome', 'Diabetes Mellitus-control-Glucose', 'Werner Syndrome-exhibit-Oligosaccharides', 'Glucose-avoid-Hypoglycemia', 'Gentamicins-associated-Kidney Diseases', 'Kidney Diseases-associated-Gentamicins', 'Gentamicins-give-Kidney Diseases', 'Atrial Fibrillation-receive-Digoxin', 'Dihydroxyacetone Phosphate-cause-Neurodegenerative Diseases', 'Glucose-linked-Mitochondrial Diseases', 'Calcinosis-induced-Glucose', 'Lymphoma, Non-Hodgkin-replaced-Doxorubicin', 'Glycogen-lead-Nerve Degeneration', 'Glycogen-contribute-Hypoxia', 'Fructosamine-increase-Diabetes Mellitus', 'Heparin, Low-Molecular-Weight-shown-Venous Thromboembolism', 'Glucose-involved-Adrenal Insufficiency', 'Ascorbic Acid-result-Death', 'Topiramate-include-Glaucoma', 'Nerve Degeneration-caused-Glucose', 'Hypertension-induce-Isosorbide Dinitrate', 'Hypertension-performed-Isosorbide Dinitrate', 'Dietary Fiber-associate-Inflammatory Bowel Diseases', 'Inflammatory Bowel Diseases-associate-Dietary Fiber', 'Diabetes Mellitus-induce-Streptozocin', 'Digoxin-avoided-Hypotension', 'Enoxaparin-compared-Venous Thromboembolism', 'Fondaparinux-reduced-Kidney Diseases', 'Syncope-found-Digoxin', 'Leukoencephalopathies-related-Glucose', 'Glucose-added-Diabetes Mellitus', 'Diabetes Mellitus-manage-Glucose', 'Glucose-decrease-Weight Loss', 'Glucose-increase-Obesity', 'Glucose-cause-Dysgeusia', 'Insulin Resistance-stimulate-Glucose', 'Fondaparinux-made-Kidney Diseases', 'Glucose-identify-Phenylketonurias', 'Diabetes Mellitus-identified-Glucose', 'Glucose-promote-Obesity', 'Hearing Disorders-include-Aminoglycosides', 'Glucose-increase-Hypoxia', 'Weight Loss-affect-Glucose', 'Doxorubicin-represent-Lymphoma, Mantle-Cell', 'Diabetes Mellitus-assessed-Glucose', 'Diabetes Mellitus-associated-Dietary Fiber', 'Dietary Fiber-associated-Diabetes Mellitus', 'Heart Failure-show-Digoxin', 'Etoposide-shown-Small Cell Lung Carcinoma', 'Congenital Hyperinsulinism-followed-Glucose', 'Stroke-found-Glucose', 'Anthocyanins-promote-Obesity', 'Glucose-live-Diabetes Mellitus', 'Osteoarthritis-compare-Glucose', 'Alzheimer Disease-undergo-Fluorodeoxyglucose F18', 'Aclarubicin-given-Leukemia, Myeloid, Acute', 'Atrophy-correct-Glucose', 'Ascorbic Acid-lowering-Chronic Disease', 'Heart Failure-focus-Ascorbic Acid', 'Hyperinsulinism-associated-Glucose', 'Glucose-associated-Hyperinsulinism', 'Cataract-use-Ascorbic Acid', 'Glucose-studied-Diabetes Mellitus', 'Trioses-increase-Diabetes Mellitus', 'Cardiovascular Diseases-accelerated-Doxorubicin', 'Purpura-improved-Ascorbic Acid', 'Death-occur-Heparin', 'Hypokalemia-receive-Digitalis Glycosides', 'Cardiotoxicity-induced-Anthracyclines', 'Daunorubicin-given-Leukemia, Myeloid, Acute', 'Heart Failure-adjusted-Digoxin', 'Cardiovascular Diseases-summarize-Glucose', 'Glucose-seen-Osteoporosis', 'Alzheimer Disease-increase-Glucose', 'Glycosaminoglycans-involve-Memory Disorders', 'Lactulose-attenuate-Bone Neoplasms', 'Death-observed-Monosaccharides', 'Atrial Fibrillation-remain-Heparin', 'Sugars-produce-Dehydration', 'Varicose Ulcer-show-Sucralfate', 'Glucose-recorded-Diabetes Mellitus', 'Ascorbic Acid-protect-Coronary Artery Disease', 'Atrophy-corrected-Hyaluronic Acid', 'Glycogen-correspond-Diabetes Mellitus', 'Hearing Loss, Central-purified-Disaccharides', 'Glycogen-increase-Infections', 'Clindamycin-reduce-Infections', 'Ascorbic Acid-related-Osteoporotic Fractures', 'Stomach Neoplasms-altered-N-Acetylneuraminic Acid', 'Hyaluronic Acid-regulate-Ovarian Diseases', 'Glucose-use-Myosarcoma', 'Heparitin Sulfate-demonstrate-Alzheimer Disease', 'Glucose-performed-Diabetes Mellitus', 'Diabetes Mellitus-sought-Glucose', 'Polyneuropathies-include-Glucose', 'Osteosarcoma-found-Doxorubicin', 'Hyaluronic Acid-used-Atrophy', 'Hyaluronic Acid-treat-Atrophy', 'Glucose-inspected-Diabetes Mellitus', 'Glucose-provided-Diabetes Mellitus', 'Ascorbic Acid-associated-Pain', 'Pain-associated-Ascorbic Acid', 'Digoxin-determined-Heart Failure', 'Alzheimer Disease-represent-Glucose', 'Death-fast-Glucose', 'Alcoholic Intoxication-involve-Digitoxin', 'Glucose-play-Alzheimer Disease', 'Glucose-suggest-Diabetes Mellitus', 'Leukemia, Myeloid, Acute-assigned-Daunorubicin', 'Acarbose-accelerate-Diabetes Mellitus, Type 2', 'Hemorrhage-correlated-Heparin', 'Ascorbic Acid-include-Hemochromatosis', 'Ascorbic Acid-seen-Cataract', 'Polysaccharides-correlated-Neoplasms', 'Polysaccharides-monitor-Carcinoma, Hepatocellular', 'Glucose-affect-Diabetes Mellitus', 'Ascorbic Acid-offer-Cataract', 'Lactose-found-Diarrhea', 'Kidney Diseases-receive-Enoxaparin', 'Intervertebral Disc Degeneration-result-Glycosaminoglycans', 'Blood Glucose-seem-Diabetes Mellitus', 'Glucose-remain-Diabetes Mellitus', 'Pyelonephritis-receive-Gentamicins', 'Glucose-assess-Diabetes Mellitus', 'Zanamivir-consider-Infections', 'Headache-associated-Glucose', 'Glucose-associated-Headache', 'Glucose-monitored-Headache', 'Cataract-prepared-Sucrose', 'Venous Thrombosis-ruled-Heparin', 'Glucose-experience-Hyperglycemia', 'Carcinoma, Merkel Cell-reveal-Doxorubicin', 'Anthracyclines-associated-Heart Diseases', 'Heart Diseases-associated-Anthracyclines', 'Pneumonia-contain-Polysaccharides', 'Doxorubicin-induce-Neoplasms', 'Doxorubicin-decrease-Neoplasms', 'Ascorbic Acid-protect-Neoplasms', 'Etoposide-compare-Small Cell Lung Carcinoma', 'Digoxin-associated-Death', 'Death-associated-Digoxin', 'Polysaccharides-developed-Chronic Disease', 'Digoxin-decrease-Fractures, Bone', 'Digoxin-reduce-Fractures, Bone', 'Glucose-classified-Glucose Intolerance', 'Polysaccharides-consider-Inflammation', 'Digoxin-diminished-Kidney Diseases', 'Gentamicins-characterize-Alzheimer Disease', 'Alzheimer Disease-require-Glucose', 'Digoxin-used-Heart Failure', 'Digoxin-shown-Heart Failure', 'Digoxin-associated-Heart Failure', 'Heart Failure-associated-Digoxin', 'Anthracyclines-determine-Drug-Related Side Effects and Adverse Reactions', 'Deoxyglucose-give-Parkinson Disease, Secondary', 'Seizures-identified-Topiramate', 'Nucleosides-show-Carcinoma, Non-Small-Cell Lung', 'Glucose-suffer-Diabetes Mellitus, Type 2', 'Obesity-caused-Glucose', 'Drug-Related Side Effects and Adverse Reactions-treated-Doxorubicin', 'Glucose-measured-Congenital Hyperinsulinism', 'Glucose-induced-Hypoxia', 'Thrombocytopenia-induced-Heparin', 'Hypertension-based-Glucose', 'Doxorubicin-induce-Cardiotoxicity', 'Insulin Resistance-improve-Glucose', 'Multiple Myeloma-preferred-Doxorubicin', 'Doxorubicin-administered-Multiple Myeloma', 'Coronary Artery Disease-persist-Glucose', 'Death-base-Glucose', 'Glycosaminoglycans-found-Ovarian Neoplasms', 'Aminoglycosides-represent-Infections', 'Pneumococcal Infections-mediated-Polysaccharides', 'Ascorbic Acid-produce-Death', 'Sugars-form-Dehydration', 'Death-reduce-Ascorbic Acid', 'Ascorbic Acid-investigate-Pneumonia', 'Ascorbic Acid-prevent-Pneumonia', 'Ascorbic Acid-cause-Lens Diseases', 'Hypertension-enhance-Ascorbic Acid', 'Anthracyclines-given-Cardiotoxicity', 'Doxorubicin-administered-Heart Failure', 'Glucose-indicate-Metabolic Syndrome', 'Glucose-correlated-Diabetes Mellitus', 'Pulmonary Embolism-distinguish-Heparin', 'Atrial Fibrillation-underused-Heparin, Low-Molecular-Weight', 'Gentamicins-associated-Meniere Disease', 'Meniere Disease-associated-Gentamicins', 'Meniere Disease-treated-Gentamicins', 'Drug-Related Side Effects and Adverse Reactions-observed-Doxorubicin', 'Glucose-induce-Heart Arrest', 'Ascorbic Acid-produce-Hyperpigmentation', 'Glucose-provide-Diabetes Mellitus', 'Glucose-include-Renal Tubular Transport, Inborn Errors', 'Ascorbic Acid-associated-Hypoxia', 'Hypoxia-associated-Ascorbic Acid', 'Sorbitol-induce-Diarrhea', 'Glucose-contribute-Alzheimer Disease', 'Digoxin-approach-Death', 'Glucose-decline-Alzheimer Disease', 'Glucose-control-Headache Disorders, Secondary', 'Fructose-result-Atherosclerosis', 'Glucose-altered-Diabetes Mellitus', 'Daunorubicin-improve-Drug-Related Side Effects and Adverse Reactions', 'Heart Failure, Diastolic-aimed-Digoxin', 'Pain-improved-Hyaluronic Acid', 'Atrial Fibrillation-occur-Digoxin', 'Gallstones-indicate-Ascorbic Acid', 'Ascorbic Acid-examine-Death', 'Daunorubicin-reveal-Blast Injuries', 'Glucose Intolerance-observed-Glucose', 'Seizures-account-Glucose', 'Huntington Disease-studied-Glucose', 'Anemia-report-Ascorbic Acid', 'Drug-Related Side Effects and Adverse Reactions-shown-Daunorubicin', 'Epilepsy-increase-Topiramate', 'Hyperglycemia-stimulate-Glucose', 'Sucralfate-compare-Breast Neoplasms', 'Ascorbic Acid-associated-Death', 'Death-associated-Ascorbic Acid', 'Metabolic Syndrome-compare-Glucose', 'Neoplasms-arise-Streptozocin', 'Hyperplasia-correlate-Streptozocin', 'Digoxin-account-Drug-Related Side Effects and Adverse Reactions', 'Digoxin-reflect-Drug-Related Side Effects and Adverse Reactions', 'Glucose-correlated-Diabetes Mellitus, Type 2', 'Pneumococcal Infections-related-Polysaccharides', 'Ascorbic Acid-linked-Alzheimer Disease', 'Glucose-occur-Acidosis, Lactic', 'Prediabetic State-assessed-Glucose', 'Alzheimer Disease-approved-Glucosinolates', 'Nucleosides-activate-Cystic Fibrosis', 'Aminoglycosides-increase-Kidney Diseases', 'Glucose-remain-Weight Loss', 'Glucose-characterized-Diabetes Mellitus', 'Sugar Phosphates-found-Diabetes Mellitus', 'Spherocytosis, Hereditary-stored-Glucose', 'Cardiac Output, Low-detected-Glucose', 'Glucose-associated-Cardiac Output, Low', 'Cardiac Output, Low-associated-Glucose', 'Glucose-fall-Cardiac Output, Low', 'Hyperglycemia-calculated-Glucose', 'Ginsenosides-induce-Inflammation', 'Glucose-decreased-Werner Syndrome', 'Neurodegenerative Diseases-inject-Hyaluronic Acid', 'Drug-Related Side Effects and Adverse Reactions-enhanced-Inositol Phosphates', 'Breast Neoplasms-treated-Anthracyclines', 'Inositol Phosphates-contribute-Lung Injury', 'Diabetes Mellitus, Type 2-provide-Glucose', 'Diabetes Mellitus-injected-Streptozocin', 'Heparin-access-Hemorrhage', 'Streptozocin-use-Diabetes Mellitus', 'Glucose-related-Kidney Diseases', 'Glucose-shown-Kidney Diseases', 'Polysaccharides-compare-Pneumococcal Infections', 'Glucose Metabolism Disorders-determined-Glucose', 'Glucose Metabolism Disorders-use-Glucose', 'Venous Thromboembolism-treated-Heparin, Low-Molecular-Weight', 'Dehydration-measured-Glucose', 'Polysaccharides-control-Meningococcal Infections', 'Nucleosides-treat-Arbovirus Infections', 'Diabetes Mellitus, Type 2-control-Glucose', 'Blood Glucose-devised-Diabetes Mellitus', 'Heparin-considered-Hemorrhage', 'Heparin-reduce-Hemorrhage', 'Glucose-differentiate-Diabetes Mellitus', 'Fluorodeoxyglucose F18-assess-Glucose Metabolism Disorders', 'Cardiac Output, High-observed-Glucose', 'Trehalose-improve-Cardiovascular Diseases', 'Glucose-result-Hypoxia', 'Osteoporosis-found-Anthocyanins', 'Glucose-related-Fatigue', 'Ascorbic Acid-show-Heart Failure', 'Sugars-inhibit-Inflammation', 'Diabetes Mellitus-observe-Glucose', 'Glucose-evaluate-Coronary Artery Disease', 'Glucose-predict-Coronary Artery Disease', 'Fluorodeoxyglucose F18-used-Alzheimer Disease', 'Fluorodeoxyglucose F18-provide-Alzheimer Disease', 'Ascorbic Acid-used-Pain', 'Ascorbic Acid-result-Breakthrough Pain', 'Neuralgia-alleviated-Ascorbic Acid', 'Fructose-increase-Gout', 'Ascorbic Acid-administer-Pain', 'Albuminuria-show-Glucose', 'Parkinson Disease-calculate-Glucose', 'Glucose-associated-Albuminuria', 'Albuminuria-associated-Glucose', 'Fructose-associated-Gout', 'Gout-associated-Fructose', 'Polysaccharides-associated-Diabetes Mellitus, Type 2', 'Diabetes Mellitus, Type 2-associated-Polysaccharides', 'Anthracyclines-result-Leukemia, Myeloid, Acute', 'Glucose-correlate-Urinary Incontinence', 'Hypertension-induce-Ascorbic Acid', 'Ventricular Fibrillation-compare-Glucose', 'Glucose-cause-Hyperglycemia', 'Glucose-induce-Hyperglycemia', 'Alzheimer Disease-related-Glucose', 'Ascorbic Acid-reduce-Infections', 'Heparin-result-Bone Diseases, Metabolic', 'Dietary Fiber-increase-Neoplasms', 'Angina, Unstable-subjected-Isosorbide Dinitrate', 'Muscular Diseases-seen-Glycogen', 'Glucose-given-Diabetes Mellitus', 'Drug-Related Side Effects and Adverse Reactions-escalated-Etoposide', 'Glucose-produce-Diabetes Mellitus', 'Ascorbic Acid-protect-Diabetes Mellitus', 'Alzheimer Disease-lack-Glucose', 'Glucose-determine-Hypertension', 'Hypertension-measure-Glucose', 'Heparin-induced-Thrombocytopenia', 'Plicamycin-limited-Drug-Related Side Effects and Adverse Reactions', 'Lactose-increase-Death', 'Anthracyclines-limited-Cardiotoxicity', 'Anthracyclines-treat-Neoplasms', 'Cardiotoxicity-include-Anthracyclines', 'Meningitis-result-Aminoglycosides', 'Meningitis-combined-Aminoglycosides', 'Pentosan Sulfuric Polyester-ameliorate-Inflammation', 'Pentosan Sulfuric Polyester-prompt-Diabetic Nephropathies', 'Ascorbic Acid-consisted-Erythema', 'Drug-Related Side Effects and Adverse Reactions-limit-Anthracyclines', 'Glycosaminoglycans-involved-Embryo Loss', 'Liver Neoplasms-evaluate-Doxorubicin', 'Flushing-use-Heparin', 'Ascorbic Acid-inhibit-Drug-Related Side Effects and Adverse Reactions', 'Glucose-diagnose-Diabetes, Gestational', 'Polysaccharides-evaluated-Pneumococcal Infections', 'Pentosephosphates-progress-Alzheimer Disease', 'Hyaluronic Acid-reduced-Osteoarthritis', 'Glucose-represent-Diabetes Mellitus', 'Intracranial Hemorrhages-range-Heparin', 'Aminoglycosides-find-Infections', 'Neoplasms-released-Agar', 'Erythritol-increased-Death', 'Death-prevented-Glucose', 'Diabetes Mellitus-caused-Streptozocin', 'Diabetes Mellitus-need-Glucose', 'Cardiotoxicity-continue-Anthracyclines', 'Diabetes Mellitus-encouraged-Glucose', 'Parkinson Disease-supplemented-Glucose', 'Immunologic Deficiency Syndromes-make-Glucose', 'Glucose-accumulate-Diabetes Mellitus', 'Diabetes Mellitus-explained-Glucose', 'Isosorbide Dinitrate-shown-Hypertension', 'Glucose-indicate-Diabetes Mellitus', 'Neoplasms-utilize-Glucose', 'Kidney Diseases-include-Aminoglycosides', 'Erectile Dysfunction-produce-Glucose', 'Glucose-performed-Weight Loss', 'Glucose-reduced-Weight Loss', 'Glucose-follow-Weight Loss', 'Glucose-attributed-Weight Loss', 'Glucose-used-Alzheimer Disease', 'Ovarian Diseases-trigger-Glucose', 'Ascorbic Acid-associated-Prostatic Neoplasms', 'Prostatic Neoplasms-associated-Ascorbic Acid', 'Doxorubicin-remain-Lymphoma, Non-Hodgkin', 'Hyaluronic Acid-play-Neoplasms', 'Ascorbic Acid-control-Hypertension', 'Glucose-avoid-Diabetes Mellitus', 'Enoxaparin-offset-Hemorrhage', 'Sugars-induce-Dehydration', 'Digoxin-reduced-Drug-Related Side Effects and Adverse Reactions', 'Seizures-assigned-Topiramate', 'Seizures-receive-Topiramate', 'Glucose-recommended-Diabetes Mellitus', 'Obesity-improve-Glucose', 'Mitochondrial Diseases-treat-Aminoglycosides', 'Hypoglycemia-defined-Glucose', 'Osteoporosis-considered-Heparin', 'Sugars-reduce-Diabetes Mellitus', 'Xerostomia-contain-Xylitol', 'Xylitol-relieve-Xerostomia', 'Gentamicins-appear-Acute Kidney Injury', 'Gentamicins-given-Kidney Diseases', 'Nucleosides-treat-Hepatitis B', 'Glucose-range-Obesity', 'Heparitin Sulfate-decrease-Atherosclerosis', 'Venous Thromboembolism-recommended-Heparin', 'Inflammation-associated-Ascorbic Acid', 'Ascorbic Acid-associated-Inflammation', 'Atrial Fibrillation-appear-Heparin, Low-Molecular-Weight', 'Ascorbic Acid-assessed-Signs and Symptoms, Respiratory', 'Oligosaccharides-produce-Acne Vulgaris', 'Heparin, Low-Molecular-Weight-present-Renal Insufficiency', 'Glucose-associated-Fractures, Bone', 'Fractures, Bone-associated-Glucose', 'Neoplasms-used-Ascorbic Acid', 'Glucose-underlie-Alzheimer Disease', 'Diabetes Mellitus-maintained-Glucose', 'Liver Failure-receive-Digoxin', 'Ascorbic Acid-fail-Aneurysm', 'Ascorbic Acid-show-Aneurysm', 'Diabetes Mellitus-classify-Glucose', 'Glycerol-affected-Alzheimer Disease', 'Glucose-associated-Leukoencephalopathies', 'Leukoencephalopathies-associated-Glucose', 'Diabetes Mellitus-lead-Glucose', 'Glucose-associated-Mitochondrial Diseases', 'Mitochondrial Diseases-associated-Glucose', 'Heparin-cleared-Thrombosis', 'Lymphoma, Large B-Cell, Diffuse-utilize-Doxorubicin', 'Isosorbide Dinitrate-relieve-Pain', 'Angina Pectoris-use-Isosorbide Dinitrate', 'Ascorbic Acid-use-Hypoxia', 'Glucose-increase-Death', 'Neoplasms-pose-Glucose', 'Ascorbic Acid-affect-Parkinson Disease', 'Ascorbic Acid-improve-Parkinson Disease', 'Polycystic Ovary Syndrome-investigated-Glucose', 'Death-result-Glycosaminoglycans', 'Venous Thrombosis-include-Heparin', 'Zanamivir-develop-Infections', 'Shock, Septic-given-Gentamicins', 'Glucose-become-Metabolic Diseases', 'Aminoglycosides-develop-Kidney Diseases', 'Sugars-accelerated-Diabetes Mellitus, Type 2', 'Ginsenosides-promote-Nerve Degeneration', 'Ginsenosides-slow-Neurodegenerative Diseases', 'Diabetes Mellitus-tested-Glucose', 'Heart Diseases-co-administered-Digoxin', 'Canagliflozin-include-Infections', 'Lymphoma, T-Cell-treat-Doxorubicin', 'Glycogen-increased-Cartilage Diseases', 'Topiramate-used-Epilepsy', 'Diabetes Mellitus, Type 2-detected-Glucose', 'Hearing Disorders-monitored-Gentamicins', 'Digoxin-tend-Death', 'Digoxin-treated-Death', 'Glucose-induce-Death', 'Glucosamine-mediate-Drug-Related Side Effects and Adverse Reactions', 'Cataract-occur-Inositol', 'Lactose-select-Lactose Intolerance', 'Lactose-contained-Lactose Intolerance', 'Sucralfate-include-Ulcer', 'Heart Failure-include-Glucose', 'Glucose-correlated-Death', 'Ascorbic Acid-increase-Death', 'Polysaccharides-inhibit-Infections', 'Glucose-enhance-Coronary Artery Disease', 'Hemorrhage-occur-Fondaparinux', 'Alzheimer Disease-provide-Fluorodeoxyglucose F18', 'Heparin-receive-Pain', 'Glucosamine-emerge-Osteoarthritis', 'Glucosamine-produce-Osteoarthritis', 'Sucrose-create-Dental Caries', 'Atrophy-correlated-Glucose', 'Glucose-selected-Sarcopenia', 'Hypertension-attenuate-Ouabain', 'Aminoglycosides-continue-Infections', 'Drug-Related Side Effects and Adverse Reactions-related-Aminoglycosides', 'Glucose-measured-Chorea', 'Alzheimer Disease-prevent-Ascorbic Acid', 'Glucose-exaggerated-Hyperglycemia', 'Pneumococcal Infections-induce-Polysaccharides', 'Polysaccharides-prevent-Guillain-Barre Syndrome', 'Diabetes Mellitus-reduce-Sugars', 'Atrial Fibrillation-increase-Digoxin', 'Genetic Diseases, Inborn-require-Ascorbic Acid', 'Stroke-estimate-Ascorbic Acid', 'Eicosapentaenoic Acid-counteract-Sarcopenia', 'Ghrelin-counteract-Sarcopenia', 'Glutathione-associated-Fatty Acids, Nonesterified', 'Fatty Acids, Nonesterified-associated-Glutathione', 'Glutathione-contribute-Fatty Acids, Nonesterified', 'Glutathione-result-Fatty Acids, Nonesterified', 'Glutathione-promote-Fatty Acids, Nonesterified', 'Oxytocin-appear-Cholesterol', 'Phospholipids-modify-Glutathione', 'Lysophosphatidylcholines-increase-Bleomycin', 'Tramadol-increase-Glutathione', 'Thioctic Acid-restore-Glutathione', 'Thioctic Acid-enhance-Glutathione', 'gamma-Linolenic Acid-associated-Hypoglycemia', 'Hypoglycemia-associated-gamma-Linolenic Acid', 'Insulin Glargine-associated-Hypoglycemia', 'Hypoglycemia-associated-Insulin Glargine', 'Dipeptides-inhibit-Dinoprostone', 'Dinoprostone-show-Drug-Related Side Effects and Adverse Reactions', 'Dipeptides-show-Drug-Related Side Effects and Adverse Reactions', 'Glutathione-reduce-Lipid Peroxides', 'Arachidonic Acid-augment-Bleomycin', 'Bleomycin-augment-Neuroblastoma', 'Oils, Volatile-increase-Oxytocin', 'Infliximab-lower-15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid', 'Alemtuzumab-receive-Mycophenolic Acid', 'Mycophenolic Acid-treated-Rituximab', 'Mycophenolic Acid-treated-Melanoma', 'Rituximab-treated-Melanoma', 'Fatty Acids-include-Denosumab', 'Dinoprostone-increase-Infliximab', 'Neurodegenerative Diseases-associated-Isoprostanes', 'Isoprostanes-associated-Neurodegenerative Diseases', 'Neurodegenerative Diseases-associated-Infliximab', 'Infliximab-associated-Neurodegenerative Diseases', 'Dinoprostone-induce-Lipopolysaccharides', 'Lipopolysaccharides-measured-Dinoprostone', 'Dinoprostone-stimulated-Lipopolysaccharides', 'Dinoprostone-produce-Lipopolysaccharides', 'Cholesterol-increase-rs1800234', 'Cholesterol-inject-Lipid A', 'Cholesterol-contain-Lipid A', 'rs2963154-associated-Cholesterol', 'Cholesterol-associated-rs2963154', 'rs10515522-associated-Cholesterol', 'Cholesterol-associated-rs10515522', 'Fatty Acids-altered-rs1800206', 'Triglycerides-associated-rs55673514', 'rs55673514-associated-Triglycerides', 'Fatty Liver-include-Triglycerides', 'Fatty Liver-drive-Triglycerides', 'rs11591147-associated-Cholesterol', 'Cholesterol-associated-rs11591147', 'rs11591147-associated-Coronary Artery Disease', 'Coronary Artery Disease-associated-rs11591147', 'rs1981429-associated-Triglycerides', 'Triglycerides-associated-rs1981429', 'rs4149056-associated-Cholesterol', 'Cholesterol-associated-rs4149056', 'rs4149056-take-Atorvastatin', 'Phosphatidylcholines-formed-rs104893875', 'Channelopathies-observed-Phosphatidylcholines', 'Triglycerides-observed-rs780094', 'Cholesterol-result-Cardiovascular Diseases', 'Calcitriol-evaluated-Fractures, Bone', 'Calcitriol-metabolized-Hypercalcemia', 'Phospholipids-observed-Lipid Metabolism Disorders', 'Cholesterol-related-Alzheimer Disease', 'Fatty Liver-correlated-Triglycerides', 'Fatty Acids-decrease-Alzheimer Disease', 'Seizures-develop-Triglycerides', 'Triglycerides-combined-Ketosis', 'G(M1) Ganglioside-protect-Neurotoxicity Syndromes', 'Plaque, Atherosclerotic-induced-Cholesterol', 'Palmitates-associated-Obesity', 'Obesity-associated-Palmitates', 'Blood Platelet Disorders-seem-Triglycerides', 'Drug-Related Side Effects and Adverse Reactions-bind-Cholesterol', 'Ischemia-enrol-Cholesterol', 'Cholesterol-correlate-Heart Failure', 'Atorvastatin-suppress-Inflammation', 'Fish Oils-associated-Carcinoma, Hepatocellular', 'Carcinoma, Hepatocellular-associated-Fish Oils', 'Diabetes Mellitus-prescribed-Atorvastatin', 'Diabetes Mellitus, Type 2-include-Triglycerides', 'Diabetes Mellitus, Type 2-performed-Triglycerides', 'Phosphatidylserines-determined-Psychomotor Disorders', 'Kidney Diseases-correlated-Cholesterol', 'Diabetes Mellitus, Type 2-mediated-Triglycerides', 'Eicosanoids-involved-Aortic Aneurysm, Abdominal', 'Fatty Acids, Volatile-monitored-Colonic Neoplasms', 'Dinoprostone-seen-Hypertension', 'Prostaglandins-accompany-Hypertension', 'Dinoprostone-noted-Hypertension', 'Hypertension-compared-Dinoprostone', 'Fatty Acids, Omega-3-associated-Autoimmune Diseases', 'Autoimmune Diseases-associated-Fatty Acids, Omega-3', 'Venlafaxine Hydrochloride-develop-Hyponatremia', 'Memory Disorders-observed-Cholesterol', 'Cholesterol-fell-Death', 'Neoplasms-decrease-Ceramides', 'Ceramides-stimulate-Niemann-Pick Disease, Type A', 'Ceramides-establish-Sphingolipidoses', 'Ceramides-characterize-Diabetes Mellitus, Type 2', 'Lipofuscin-reduce-Seizures', 'Ceramides-implicated-Mitochondrial Diseases', 'Ceramides-improve-Mitochondrial Diseases', 'Ceramides-measured-Neoplasms', 'Cholesterol-recognized-Cardiovascular Diseases', 'Fatty Acids-result-Death', 'Genetic Diseases, Inborn-provide-Cholesterol', 'Cholesterol-associated-Carotid Artery Diseases', 'Carotid Artery Diseases-associated-Cholesterol', 'Fatty Acids, Omega-3-provide-Alzheimer Disease', 'Cholesterol-show-Movement Disorders', 'Gangliosides-cause-Basal Ganglia Diseases', 'Thioctic Acid-reduce-Drug-Related Side Effects and Adverse Reactions', 'Hypertriglyceridemic Waist-use-Triglycerides', 'Cardiovascular Diseases-increase-Triglycerides', 'Coronary Artery Disease-associated-Sterols', 'Sterols-associated-Coronary Artery Disease', 'Pregnancy, Prolonged-improve-Lipofuscin', 'Cholesterol-decrease-Hypercholesterolemia', 'Diarrhea-induced-Castor Oil', 'Metabolic Syndrome-define-Cholesterol', 'Mycophenolic Acid-used-Myasthenia Gravis', 'Leg Injuries-increase-Epoprostenol', 'Alzheimer Disease-reveal-Cholesterol', 'Fatty Acids-interfere-Chemical and Drug Induced Liver Injury', 'Diabetes Mellitus-evaluate-Fatty Acids, Omega-3', 'Laryngitis-associated-Triglycerides', 'Triglycerides-associated-Laryngitis', 'Cholesterol-approaches-Osteoporosis', 'Cholesterol-found-Alzheimer Disease', 'Cholesterol-correspond-Cardiovascular Diseases', 'Hypertension-measure-Prostaglandins E', 'Hypertension-decrease-Prostaglandins E', 'Death-cause-Calcitriol', 'Cholesterol-include-Dyslipidemias', 'Epoprostenol-correlate-Stroke', 'Cardiovascular Diseases-related-Cholesterol', 'Ceramides-implicated-Neurodegenerative Diseases', 'Thioctic Acid-remain-Heredodegenerative Disorders, Nervous System', 'Cholesterol-correspond-Death', 'Phospholipids-potentiate-Lung Injury', 'Corneal Ulcer-found-Capsaicin', 'Phospholipids-exacerbate-Inflammation', 'Psoriasis-respond-Calcitriol', 'Triglycerides-observed-Hypertension', 'Autoimmune Diseases-exacerbated-Trans Fatty Acids', 'Dyslipidemias-reduce-Cholesterol', 'Death-prevented-Butyrates', 'Phospholipids-provide-Alzheimer Disease', 'Fatty Acids, Volatile-produced-Colonic Neoplasms', 'Ceramides-stimulate-Death', 'Cholesterol-given-Diabetes Mellitus', 'Fatty Acids-involve-Osteoporosis', 'Fatty Acids-prevent-Osteoporosis', 'Prostaglandins-make-Hyperemia', 'Prostaglandins-associated-Bone Neoplasms', 'Bone Neoplasms-associated-Prostaglandins', 'Sodium Dodecyl Sulfate-used-Alzheimer Disease', 'Sphingolipids-remove-Niemann-Pick Disease, Type A', 'Fatty Acids-remove-Coronary Artery Disease', 'Hyperammonemia-enhance-Valproic Acid', 'Hearing Loss-associated-Sodium Dodecyl Sulfate', 'Sodium Dodecyl Sulfate-associated-Hearing Loss', 'Isoprostanes-play-Alzheimer Disease', 'Diabetes Mellitus-correlated-Triglycerides', 'Kidney Diseases-increase-Cholesterol', 'Ovarian Neoplasms-separated-Sodium Dodecyl Sulfate', 'Ceramides-abrogated-Infections', 'Epoprostenol-found-Hypertension, Pulmonary', 'Abnormalities, Drug-Induced-interpreted-Fatty Acids', 'Abnormalities, Drug-Induced-raise-Fatty Acids', 'Glucose Intolerance-decrease-Cholesterol', 'Fish Oils-confer-Heart Diseases', 'Isoprostanes-reported-Alzheimer Disease', 'Fish Oils-affect-Inflammation', 'Docosahexaenoic Acids-increased-Alzheimer Disease', 'Phospholipids-play-Alzheimer Disease', 'Phospholipids-altered-Alzheimer Disease', 'Sphingolipids-pursued-Neurodegenerative Diseases', 'Thioctic Acid-considered-Neurodegenerative Diseases', 'Lecithins-lead-Vision Disorders', 'Phosphatidylcholines-associated-Memory Disorders', 'Memory Disorders-associated-Phosphatidylcholines', 'Mycophenolic Acid-associated-Infections', 'Infections-associated-Mycophenolic Acid', 'Lipofuscin-study-Neurodegenerative Diseases', 'Fatty Acids, Omega-3-investigate-Sarcopenia', 'Docosahexaenoic Acids-exhibit-Breast Neoplasms', 'Calcitriol-used-Alzheimer Disease', 'Stargardt Disease-occur-Fatty Acids, Unsaturated', 'Tramadol-predict-Wounds and Injuries', 'Phosphatidylcholines-show-Hearing Loss', 'Obesity-contribute-Cholesterol', 'Cholesterol-relate-Coronary Artery Disease', 'Glycerylphosphorylcholine-measured-Alzheimer Disease', 'Cholecalciferol-suppress-Hyperparathyroidism', 'Phospholipids-mimic-Alzheimer Disease', 'Cholesterol-decline-Thromboembolism', 'Cholesterol-alter-Stroke', 'Ceramides-induced-Niemann-Pick Disease, Type A', 'Breast Neoplasms-produce-Ceramides', 'Phospholipids-prepared-Cataract', 'Dyslipidemias-rose-Triglycerides', 'Metabolic Syndrome-established-Cholesterol', 'Cholesterol-identified-Coronary Artery Disease', 'Cholesterol-show-Parkinson Disease', 'Cholesterol-link-Coronary Artery Disease', 'Cholesterol-reduce-Atherosclerosis', 'Cholesterol-link-Death', 'Alzheimer Disease-reduce-Cholesterol', 'Fatty Acids, Volatile-linked-Cerebrovascular Disorders', 'Fatty Acids-prove-Neoplasms', '3-Hydroxybutyric Acid-serve-Gout', 'Calcitriol-compare-Osteoporosis', 'Valproic Acid-identified-Thrombocytopenia', 'Tramadol-used-Low Back Pain', 'Tramadol-indicate-Substance-Related Disorders', 'Coronary Artery Disease-experience-Cholesterol', 'Femoral Neck Fractures-receive-Ergocalciferols', 'Hyperglycemia-improve-Cholesterol', 'Death-noted-Cholesterol', 'Triglycerides-associated-Kidney Diseases', 'Kidney Diseases-associated-Triglycerides', 'Fatty Acids, Omega-6-associated-Fractures, Bone', 'Fractures, Bone-associated-Fatty Acids, Omega-6', 'Cholesterol-associated-Fractures, Bone', 'Fractures, Bone-associated-Cholesterol', 'Sodium Dodecyl Sulfate-exacerbate-Coronary Artery Disease', 'Heptanoates-applied-Diabetes Mellitus', 'Capsaicin-use-Pain', 'Cholesterol-augment-Pain', 'Weight Gain-associated-Cholesterol', 'Cholesterol-associated-Weight Gain', 'Tramadol-relieve-Pain, Postoperative', 'Cardiovascular Diseases-defined-Cholesterol', 'Stroke-receive-Fatty Acids, Omega-3', 'Fatty Acids, Omega-3-decrease-Cardiac Output, Low', 'Eicosapentaenoic Acid-reduce-Arrhythmias, Cardiac', 'Cataract-occur-Phospholipids', 'Cholestanol-associated-Death', 'Death-associated-Cholestanol', 'Iloprost-increase-Osteosarcoma', 'Breast Neoplasms-speak-Cholesterol', 'Alzheimer Disease-find-Docosahexaenoic Acids', 'Chemical and Drug Induced Liver Injury-associated-Triglycerides', 'Triglycerides-associated-Chemical and Drug Induced Liver Injury', 'Erythema-studied-Dinoprostone', 'Cholesterol-keep-Coronary Artery Disease', 'Valproic Acid-prevent-Alzheimer Disease', 'Fatty Acids, Omega-3-inhibit-Vascular Calcification', 'Anemia, Hemolytic-triggered-Phosphatidylserines', 'Cardiovascular Diseases-estimated-Cholesterol', 'Palm Oil-offset-Inflammation', 'Triglycerides-prevent-Death', 'Cholesterol-reduce-Leukoencephalopathies', 'Hypercholesterolemia-defined-Cholesterol', 'Osteoporosis-prescribed-Cholecalciferol', 'Phosphatidylserines-undergo-Wounds and Injuries', 'Cholesterol-show-Drug-Related Side Effects and Adverse Reactions', 'Lipid Peroxides-elevated-Obesity', 'Oxysterols-associated-Rare Diseases', 'Rare Diseases-associated-Oxysterols', 'Calcitriol-reduce-Calcinosis', 'Fatty Acids-validate-Dementia', 'Hypercholesterolemia-induced-Cholesterol', 'Lipofuscin-accumulate-Muscular Dystrophies', 'Lipofuscin-use-Muscular Dystrophy, Duchenne', 'Lipofuscin-increase-Muscular Dystrophies', 'Fatty Acids-adjusted-Cardiovascular Diseases', 'Cholesterol-unravel-Gallstones', 'Cardiovascular Diseases-associated-Atorvastatin', 'Atorvastatin-associated-Cardiovascular Diseases', 'Calcitriol-result-Kidney Diseases', 'Cholesterol-produce-Mitochondrial Diseases', 'Pain-meet-Tramadol', 'Tramadol-reduce-Pain', 'Tramadol-use-Pain', 'Lipofuscin-impair-Proteostasis Deficiencies', 'Sphingolipids-associated-Cataract', 'Cataract-associated-Sphingolipids', 'Fatty Acids, Unsaturated-maintain-Skin Diseases', 'Dysmenorrhea-prescribed-Prostaglandins', 'Liver Failure-associated-Fluvastatin', 'Fluvastatin-associated-Liver Failure', 'Lipid Peroxides-obtained-Cataract', 'Cholesterol-play-Alzheimer Disease', 'Cholesterol-characterized-Obesity', 'Lipofuscin-lead-Death', 'Lipofuscin-associated-Eye Diseases', 'Eye Diseases-associated-Lipofuscin', 'Cholesterol-defined-Diabetes Mellitus', 'Necrosis-elevate-Ionomycin', 'Isoprostanes-precede-Alzheimer Disease', 'Cholecalciferol-developed-Alzheimer Disease', 'Fatty Acids, Omega-3-inhibit-Inflammation', 'Melanoma-involve-Cholesterol', 'Melanoma-affect-Cholesterol', 'Hyperkinesis-associated-Arachidonic Acid', 'Arachidonic Acid-associated-Hyperkinesis', 'Cholesterol-indicate-Atherosclerosis', 'Drug-Related Side Effects and Adverse Reactions-seem-Cholesterol', 'Cholesterol-compensate-Neuroblastoma', 'Prostaglandins E-play-Aortic Aneurysm, Abdominal', 'Drug-Related Side Effects and Adverse Reactions-increased-Arachidonic Acid', 'Alzheimer Disease-show-Prostaglandins', 'Cholecalciferol-tested-Fractures, Bone', 'Phosphatidylcholines-examined-Alzheimer Disease', 'Phospholipids-reverse-Glycogen Storage Disease Type II', 'Thioctic Acid-reverse-Neurologic Manifestations', 'Gangliosides-belong-Adenomatous Polyposis Coli', 'Obesity, Metabolically Benign-focus-Triglycerides', 'Dementia-oxidized-Cholesterol', 'Cholesterol-found-Thyroiditis, Autoimmune', 'Cholesterol-involved-Mitochondrial Diseases', 'Choroidal Neovascularization-mimic-Lipofuscin', 'Obesity-examined-Cholesterol', 'Cholesterol-associated-End Stage Liver Disease', 'End Stage Liver Disease-associated-Cholesterol', 'Cholesterol-prevent-Coinfection', 'Docosahexaenoic Acids-treat-Alzheimer Disease', 'Alzheimer Disease-proposed-Docosahexaenoic Acids', 'Leukemia, Myeloid, Acute-treated-Calcitriol', 'Death-associated-Docosahexaenoic Acids', 'Docosahexaenoic Acids-associated-Death', 'Ergocalciferols-increase-Death', 'Cholecalciferol-increase-Nephrolithiasis', 'Calcitriol-increase-Hypercalcemia', 'Metabolic Syndrome-determined-Cholesterol', 'Cholesterol-act-Alzheimer Disease', 'Cholesterol-attenuate-Fractures, Spontaneous', 'Lipid Metabolism Disorders-decrease-Triglycerides', 'Lipofuscin-induce-Lysosomal Storage Diseases', 'Coronary Artery Disease-lowering-Cholesterol', 'Docosahexaenoic Acids-modulate-Alzheimer Disease', 'Fatty Acids, Unsaturated-evaluate-Atherosclerosis', 'Capsaicin-prevent-Pneumonia, Aspiration', 'Prostaglandins-promote-Thrombosis', 'Fatty Acids, Nonesterified-found-Hyperinsulinism', 'Gangliosides-accumulate-Cataract', 'Glycolipids-lead-Cataract', 'Fatty Acids, Unsaturated-suggest-Anophthalmos', 'Cholesterol-associated-Plaque, Atherosclerotic', 'Plaque, Atherosclerotic-associated-Cholesterol', 'Gangliosides-used-Neoplasms', 'Prostaglandins-overexpressed-Inflammation', 'Cholesterol-associated-Chronic Kidney Disease-Mineral and Bone Disorder', 'Chronic Kidney Disease-Mineral and Bone Disorder-associated-Cholesterol', 'Colorectal Neoplasms-support-Butyrates', 'Muscular Dystrophy, Duchenne-increase-Fatty Acids, Omega-3', 'Fatty Acids, Omega-3-slow-Atrophy', 'Tramadol-use-Pain, Postoperative', 'Triglycerides-decrease-Learning Disabilities', 'Hexanols-generated-Breast Neoplasms', 'Cholesterol-influence-Coronary Artery Disease', 'Prostatic Neoplasms-lead-Cholesterol', 'Fatty Acids-associated-Death', 'Death-associated-Fatty Acids', 'Triglycerides-found-Neoplasms', 'Thromboxane B2-decrease-Thrombosis', 'Thromboxane B2-increased-Thrombosis', 'Alzheimer Disease-localized-Lipofuscin', 'Alzheimer Disease-contain-Lipofuscin', 'Cholesterol-associated-Malnutrition', 'Malnutrition-associated-Cholesterol', 'Cholesterol-remain-Coronary Artery Disease', 'Death-seem-Cholesterol', 'Leukotrienes-offer-Pulmonary Disease, Chronic Obstructive', 'Leukotrienes-benefit-Pulmonary Disease, Chronic Obstructive', 'Ergocalciferols-prevent-Fractures, Bone', 'Eczema-contain-Lanolin', 'Valproic Acid-develop-Hypokinesia', 'Urinary Tract Infections-represent-Cilastatin, Imipenem Drug Combination', 'Valproic Acid-treat-Psychomotor Agitation', 'Psychomotor Agitation-treat-Valproic Acid', 'Bone Neoplasms-lowering-Cholesterol', 'Glycosphingolipids-accumulated-Fabry Disease', 'Vascular Calcification-reflect-Cholecalciferol', 'Phlebitis-receive-Alprostadil', 'Phlebitis-necessitate-Alprostadil', 'Alprostadil-continue-Phlebitis', 'Alprostadil-reach-Phlebitis', 'Alprostadil-avoid-Phlebitis', 'Cholesterol-issue-Cardiovascular Diseases', 'Atherosclerosis-compare-Triglycerides', 'Hyperlipidemias-increase-Triglycerides', 'Coronary Artery Disease-achieve-Cholesterol', 'Ceramides-lead-Fasciculation', 'Renal Insufficiency, Chronic-recommended-Ergocalciferols', 'Adrenal Insufficiency-reduce-Cholesterol', 'Gangliosides-lead-Neurodegenerative Diseases', 'Fatty Acids-become-Cardiovascular Diseases', 'Lipofuscin-indicate-Neuronal Ceroid-Lipofuscinoses', 'Chemical and Drug Induced Liver Injury-enable-Cholesterol', 'Chemical and Drug Induced Liver Injury-induce-Cholesterol', 'Stroke-decreased-Sodium Dodecyl Sulfate', 'Oils-reveal-Carcinoma, Hepatocellular', 'Carcinogenesis-include-Cholesterol', 'Fatty Acids-influence-Neoplasms', 'Neuralgia-approved-Capsaicin', 'Tramadol-protect-Venous Thromboembolism', 'Atherosclerosis-correlate-Cholesterol', 'Thioctic Acid-studied-Mitochondrial Diseases', 'Muscle Rigidity-increase-Cholesterol', 'Cholesterol-treat-Coronary Artery Disease', 'Prostaglandins-maintain-Inflammation', 'Atherosclerosis-implicated-Prostaglandins', 'Prostaglandins-implicated-Atherosclerosis', 'Cholesterol-accord-Atherosclerosis', 'Cholesterol-play-Atherosclerosis', 'Seizures-rated-Valproic Acid', 'Hypertriglyceridemia-reflect-Fatty Acids', 'Stroke-attributed-Cholesterol', 'Stroke-demonstrated-Cholesterol', 'Cholesterol-provide-Stroke', 'Fatty Acids, Unsaturated-lead-Blood Protein Disorders', 'Cholesterol-confirm-Malnutrition', 'Atorvastatin-identified-Memory Disorders', 'Arthritis, Rheumatoid-associated-Triglycerides', 'Triglycerides-associated-Arthritis, Rheumatoid', 'Ethiodized Oil-treat-Arteriovenous Malformations', 'Cholecalciferol-cause-Bone Diseases, Metabolic', 'Cholecalciferol-recommended-Hip Fractures', 'Sodium Oxybate-live-HIV Infections', 'Cardiovascular Diseases-associated-Prostaglandins', 'Prostaglandins-associated-Cardiovascular Diseases', 'Death-predicted-Cholesterol', 'Atherosclerosis-accumulate-Arachidonic Acid', 'Sphingolipids-suggest-Neurodegenerative Diseases', 'Phospholipids-induce-Choroidal Neovascularization', 'Lipofuscin-observed-Neurodegenerative Diseases', 'Glaucoma-contain-Lipofuscin', 'Triglycerides-increases-Weight Loss', 'Cholesterol-prevent-Tangier Disease', 'Triglycerides-associated-Hearing Loss', 'Hearing Loss-associated-Triglycerides', 'Cholestasis, Intrahepatic-induce-Phospholipids', 'Cholestasis, Intrahepatic-result-Phospholipids', 'Cholesterol-represent-Cardiovascular Diseases', 'Palmitates-decrease-Pulmonary Disease, Chronic Obstructive', 'Cholesterol-emerge-Death', 'Adenomatous Polyposis Coli-measured-Cholecalciferol', 'Inflammation-reduce-Prostaglandins', 'Cholesterol-related-Coronary Artery Disease', 'Cholesterol-found-Coronary Artery Disease', 'Osteomalacia-corrected-Ergocalciferols', 'Tramadol-provide-Neuralgia', 'Tramadol-include-Neuralgia', 'Cholesterol-used-Plaque, Atherosclerotic', 'Hyponatremia-discontinued-Venlafaxine Hydrochloride', 'Calcitriol-ameliorate-Progeria', 'Cholesterol-affected-Neurodegenerative Diseases', 'Cholesterol-enhance-Alzheimer Disease', 'Cholesterol-develop-Alzheimer Disease', 'Atorvastatin-modulate-Inflammation', 'Arachidonic Acid-associated-Fractures, Bone', 'Fractures, Bone-associated-Arachidonic Acid', 'Fatty Acids, Omega-3-prevent-Asthma', 'Cholesterol-promote-Inflammation', 'Capsaicin-relieve-Neuralgia', 'Thrombosis-mediated-Epoprostenol', 'Valproic Acid-quantify-Epilepsy', 'Valproic Acid-generalise-Seizures', 'Death-display-Triglycerides', 'Fatty Acids, Omega-3-act-Inflammation', 'Phosphatidylcholines-improve-Alzheimer Disease', 'Chorioretinitis-test-Cholesterol', 'Parkinson Disease-raise-Cholesterol', 'Parkinson Disease-occur-Cholesterol', 'Cardiac Output, Low-report-Cholesterol', 'Renal Insufficiency, Chronic-consist-Mycophenolic Acid', 'Fatty Acids, Nonesterified-cause-Metabolic Diseases', 'Triglycerides-linked-Cardiovascular Diseases', 'Thromboembolism-referred-Cholesterol', 'Metabolic Syndrome-based-Cholesterol', 'Oils-promote-Fat Necrosis', 'Alzheimer Disease-exhibit-Lipid Peroxides', 'Fatty Acids-contribute-Aortic Aneurysm, Abdominal', 'Cholesterol-associated-Peripheral Vascular Diseases', 'Peripheral Vascular Diseases-associated-Cholesterol', 'Fatty Acids-reduce-Death', 'Endocannabinoids-shared-Alzheimer Disease', 'Docosahexaenoic Acids-associated-Memory Disorders', 'Memory Disorders-associated-Docosahexaenoic Acids', 'Atorvastatin-produce-Atherosclerosis', 'Calcifediol-indicate-Adrenal Insufficiency', 'Phosphatidic Acids-enhance-Ventricular Remodeling', 'Phosphatidic Acids-stimulate-Ventricular Remodeling', 'Ventricular Remodeling-enhance-Phosphatidic Acids', 'Cholesterol-remain-Death', 'Cholesterol-observed-Diabetes Mellitus', 'Hypercalcemia-induce-Calcitriol', 'Fatty Acids, Omega-3-delay-Ovarian Diseases', 'Lipofuscin-increase-Stargardt Disease', 'Cholesterol-play-Bile Reflux', 'Atherosclerosis-effected-Cholesterol', 'Cholesterol-prescribed-Coronary Artery Disease', 'Eicosanoids-reflect-Inflammation', 'Diabetes Mellitus-associate-Cholesterol', 'Cholesterol-associate-Diabetes Mellitus', 'Valproic Acid-associated-Nausea', 'Nausea-associated-Valproic Acid', 'Valproic Acid-reduce-Headache Disorders, Secondary', 'Alzheimer Disease-aid-Isoprostanes', 'Cholesterol-affected-Alzheimer Disease', 'Lipofuscin-implicated-Retinal Degeneration', 'Cholesterol-screen-Coronary Artery Disease', 'Coronary Artery Disease-consider-Cholesterol', 'Dyskinesia, Drug-Induced-assigned-G(M1) Ganglioside', 'Calcifediol-checked-Colorectal Neoplasms', 'Venlafaxine Hydrochloride-lowered-Kidney Diseases', 'Venlafaxine Hydrochloride-associated-Hypotension, Orthostatic', 'Hypotension, Orthostatic-associated-Venlafaxine Hydrochloride', 'Thioctic Acid-reduce-Death', 'Phospholipids-make-Neurodegenerative Diseases', 'Cholesterol-progress-Thrombosis', 'Fatty Acids-show-Alzheimer Disease', 'Gangliosides-isolated-Cataract', 'Gangliosides-found-Cataract', 'Cataract-show-Gangliosides', 'Hypertension-receive-Cholecalciferol', 'Calcitriol-prevent-Neoplasms', 'Fatty Acids, Unsaturated-become-Neurodegenerative Diseases', 'Neuralgia-include-Valproic Acid', 'Asthma, Exercise-Induced-mediated-Prostaglandins', 'Fatty Acids, Unsaturated-associated-Neurodegenerative Diseases', 'Neurodegenerative Diseases-associated-Fatty Acids, Unsaturated', 'Cholesterol-identified-Kidney Diseases', 'Cholesterol-worsen-Kidney Diseases', 'Cholecalciferol-derived-Prostatic Hyperplasia', 'Glycosphingolipids-accumulate-Cataract', 'Cholesterol-find-Death', 'Glycolipids-purified-Cataract', 'Gangliosides-characterize-Cataract', 'Calcitriol-inhibit-Inflammation', 'Psychosine-correlate-Parkinson Disease', 'Oxylipins-implicated-Cardiovascular Diseases', 'Oxylipins-characterized-Cardiovascular Diseases', 'Cardiovascular Diseases-gain-Oxylipins', 'Cardiovascular Diseases-manipulate-Oxylipins', 'Obesity-associated-Endocannabinoids', 'Endocannabinoids-associated-Obesity', 'Prostaglandins-studied-Hypertension', 'Fatty Acids, Omega-3-reduce-Bone Neoplasms', 'Fatty Acids, Omega-3-assessed-Death', 'Cardiac Output, Low-increase-Fatty Acids', 'Prostaglandins-augment-Ischemia', 'Cholesterol-produce-Arteriosclerosis', 'Fatty Acids, Unsaturated-regulate-Neoplasms', 'Docosahexaenoic Acids-provide-Cardiovascular Diseases', 'Cholecalciferol-recommended-Osteoporosis', 'Docosahexaenoic Acids-reduce-Alzheimer Disease', 'Cholesterol-induce-Drug-Related Side Effects and Adverse Reactions', 'Ceramides-improve-Glucose Metabolism Disorders', 'Ceroid-impair-Atherosclerosis', 'Fatty Acids, Omega-3-lowering-Dementia', 'Cholesterol-combat-Alzheimer Disease', 'Neoplasms-increased-Mycophenolic Acid', 'Docosahexaenoic Acids-suppress-Arrhythmias, Cardiac', 'Lipoxins-function-Arrhythmias, Cardiac', 'Cholesterol-fulfil-Metabolic Syndrome', 'Cholesterol-explain-Death', 'Cholesterol-use-Death', 'Fatty Acids, Unsaturated-associated-Brain Diseases', 'Brain Diseases-associated-Fatty Acids, Unsaturated', 'Ceramides-involved-Neurodegenerative Diseases', 'Fatty Acids, Omega-3-do-Inflammation', 'Death-related-Trans Fatty Acids', 'Death-minimize-Trans Fatty Acids', 'Metabolic Syndrome-made-Cholesterol', 'Calcitriol-downregulated-Neoplasms', 'Infertility, Female-measure-Lipid Peroxides', 'Cardiovascular Diseases-produce-Cholesterol', 'Atorvastatin-experience-Muscular Diseases', 'Glycosphingolipids-analysed-Parkinson Disease', 'Prostaglandins-induced-Inflammation', 'Heart Diseases-play-Prostaglandins', 'Malabsorption Syndromes-associated-Calcifediol', 'Calcifediol-associated-Malabsorption Syndromes', 'Olive Oil-mediate-Chronic Disease', 'Cholesterol-used-Metabolic Syndrome', 'Calcitriol-worsen-Renal Insufficiency, Chronic', 'Triglycerides-associate-Carcinoma, Hepatocellular', 'Carcinoma, Hepatocellular-associate-Triglycerides', 'Hypertension-achieve-Cholesterol', 'Triglycerides-show-Diabetes Mellitus, Type 2', 'Cholesterol-increased-Myocardial Infarction', 'Obesity-avoid-Fatty Acids, Omega-3', 'Osteoarthritis-induced-Prostaglandins', 'Cholesterol-decrease-Cardiovascular Diseases', 'Dinoprostone-increase-Infections', 'Ceramides-upregulate-Leukemia, Myelogenous, Chronic, BCR-ABL Positive', 'Palmitic Acid-decrease-Cardiac Output, Low', 'Cholesterol-related-Weight Loss', 'Hypercholesterolemia-conferred-Cholesterol', 'Cholesterol-associated-Coronary Occlusion', 'Coronary Occlusion-associated-Cholesterol', 'Dolichols-cause-Death', 'Cholesterol-assess-Death', 'Fatty Acids-associated-Metabolic Syndrome', 'Metabolic Syndrome-associated-Fatty Acids', 'Cholecalciferol-associated-Polycystic Ovary Syndrome', 'Polycystic Ovary Syndrome-associated-Cholecalciferol', 'Lipofuscin-suggest-Adrenal Insufficiency', 'Phospholipids-increase-Metabolic Diseases', 'Lipofuscin-examine-Alzheimer Disease', 'Neuroaxonal Dystrophies-accumulated-Lipofuscin', 'Hemorrhage-show-Fish Oils', 'Alzheimer Disease-used-Endocannabinoids', 'Death-examine-Cholesterol', 'Calcitriol-contribute-Hyperparathyroidism, Secondary', 'Linoleic Acid-reduced-Coronary Artery Disease', 'Calcitriol-correct-Malabsorption Syndromes', 'Docosahexaenoic Acids-show-Retinal Degeneration', 'Cholesterol-detect-Dyslipidemias', 'Diabetes Mellitus-fead-Cholesterol', 'Pigmentation Disorders-occupied-Lipofuscin', 'Acute Coronary Syndrome-achieve-Cholesterol', 'Cholesterol-lead-Atherosclerosis', 'Sleep Apnea, Obstructive-demonstrate-Sodium Oxybate', 'Capsaicin-used-Neuralgia', 'Capsaicin-treat-Neuralgia', 'Hyperalgesia-induced-Capsaicin', 'Pneumonia-down-Cholesterol', 'Cholesterol-used-Venous Thrombosis', 'Atherosclerosis-appear-Cholesterol', 'Cholesterol-related-Seizures', 'Capsaicin-reported-Neoplasms', 'Capsaicin-prevent-Cataract', 'X-Linked Combined Immunodeficiency Diseases-produced-Cholesterol', 'Alprostadil-inhibit-Thrombosis', 'Ceramides-implicated-Obesity', 'Cholecalciferol-produce-Malabsorption Syndromes', 'Death-reduced-Atorvastatin', 'Fish Oils-associated-Obesity', 'Obesity-associated-Fish Oils', 'Cholesterol-show-Aneurysm', 'Atrial Fibrillation-used-Lipofuscin', 'Lipofuscin-play-Alzheimer Disease', 'Lipofuscin-worsen-Proteinuria', 'Inflammation-lead-Lipofuscin', 'Cholesterol-observed-Niemann-Pick Disease, Type C', 'Metabolic Syndrome-base-Cholesterol', 'Phosphatidylinositols-implicate-Hematologic Diseases', 'Cholesterol-associated-Arcus Senilis', 'Arcus Senilis-associated-Cholesterol', 'Cholesterol-decrease-Dwarfism, Pituitary', 'Triglycerides-produce-Muscular Diseases', 'Cardiovascular Diseases-start-Triglycerides', 'Cholesterol-assess-Dementia', 'Lipofuscin-suggest-Hyperkinesis', 'Death-related-Cholesterol', 'Chemical and Drug Induced Liver Injury-promote-Fatty Acids', 'Phosphatidylserines-contribute-Nerve Degeneration', 'Ceramides-play-Skin Diseases', 'Ceramides-result-Skin Diseases', 'Ceramides-observed-Skin Diseases', 'Werner Syndrome-show-Phospholipids', 'Sterols-associated-Sarcopenia', 'Sarcopenia-associated-Sterols', 'Cholecalciferol-ensue-Fractures, Bone', 'Phospholipids-used-Neurodegenerative Diseases', 'Fatty Acids, Omega-3-prevent-Cardiovascular Diseases', 'Fatty Acids-reflect-Mitochondrial Diseases', 'Cholesterol-recognized-Atherosclerosis', 'Valproic Acid-prescribed-Seizures', 'Ceramides-predict-Dementia', 'Prostaglandins-involve-Mucositis', 'Osteoporosis-maintain-Cholecalciferol', 'Valproic Acid-treat-Seizures', 'Cholesterol-correlated-Coronary Artery Disease', 'Cholesterol-identified-Cardiovascular Diseases', 'Cholecalciferol-recommended-Immunologic Deficiency Syndromes', 'Ceramides-predict-Death', 'Prostaglandins-treat-Kidney Diseases', 'Death-record-Cholesterol', 'Cholesterol-link-Atherosclerosis', 'Valproic Acid-protect-Drug-Related Side Effects and Adverse Reactions', 'Dinoprostone-regulate-Fasciculation', 'Lysophosphatidylcholines-associated-Mitochondrial Diseases', 'Mitochondrial Diseases-associated-Lysophosphatidylcholines', 'Thioctic Acid-act-Neoplasms', 'Calcitriol-reserved-Osteoporosis', 'Calcitriol-establish-Osteoporosis', 'G(M1) Ganglioside-show-Alzheimer Disease', 'Cholesterol-correlate-Atherosclerosis', 'Atorvastatin-reduce-HIV Infections', 'Neurodegenerative Diseases-mitigate-Cholesterol', 'Lipofuscin-accumulate-Alzheimer Disease', 'Lipofuscin-co-localize-Alzheimer Disease', 'Metabolic Syndrome-accompanied-Triglycerides', 'Death-prescribed-Atorvastatin', 'Liver Diseases-induce-Cholesterol', 'Mitochondrial Diseases-derive-Prostaglandins', 'Gangliosides-play-Parkinson Disease', 'Atorvastatin-receive-Death', 'Calcitriol-associated-Hypercalcemia', 'Hypercalcemia-associated-Calcitriol', 'Infections-demonstrated-Fatty Acids, Unsaturated', 'Basiliximab-combined-Cyclosporine', 'Teriparatide-support-Osteoporosis', 'Denosumab-support-Osteoporosis', 'Lymphoma-initiated-Cyclosporine', 'Lymphoma-initiated-Rituximab', 'Glutathione-change-Huntington Disease', 'Arthritis, Infectious-treated-Vancomycin', 'Glutathione-considered-Alzheimer Disease', 'Iatrogenic Disease-decrease-Thyrotropin', 'Insulin Glargine-associated-Neoplasms', 'Neoplasms-associated-Insulin Glargine', 'Enalapril-cure-Hypertension', 'Hypertension-used-Enalapril', 'Glutathione-remain-Cataract', 'Dactinomycin-induce-Lymphoma, Large B-Cell, Diffuse', 'Hypertension-examined-Enalapril', 'Death-attributed-Enalapril', 'Enalapril-attenuate-Hypokalemia', 'Taste Disorders-occur-Enalapril', 'Enalapril-tolerated-Renal Insufficiency', 'Proteinuria-improve-Enalapril', 'Exanthema-recur-Enalapril', 'Lung Diseases-reduce-Glutathione', 'Glutathione-decreased-Alzheimer Disease', 'Neoplasms-associated-Glutathione', 'Glutathione-associated-Neoplasms', 'Glutathione-make-Neoplasms', 'Gingival Overgrowth-associated-Cyclosporine', 'Cyclosporine-associated-Gingival Overgrowth', 'Weight Loss-regulate-Ghrelin', 'Lisinopril-determined-Heart Failure', 'Vancomycin-known-Kidney Diseases', 'Glutathione-associated-Infections', 'Infections-associated-Glutathione', 'Heart Failure-prescribed-Lisinopril', 'Bleomycin-followed-Neoplasms', 'Ghrelin-remain-Obesity', 'Obesity-remain-Ghrelin', 'Ghrelin-associated-Obesity', 'Obesity-associated-Ghrelin', 'Parathyroid Hormone-result-Vascular Calcification', 'Ghrelin-result-Tetany', 'Octreotide-predict-Insulinoma', 'Glutathione-associated-Cataract', 'Cataract-associated-Glutathione', 'Glutathione-summarize-Cataract', 'Drug-Related Side Effects and Adverse Reactions-correlate-Bleomycin', 'Hypothyroidism-stratified-Thyrotropin', 'Vancomycin-reserved-Infections', 'Glutathione-correlated-Atrial Fibrillation', 'Bleomycin-investigate-Lung Neoplasms', 'Neurotoxicity Syndromes-protect-Glutathione', 'Death-associated-Ghrelin', 'Ghrelin-associated-Death', 'Drug-Related Side Effects and Adverse Reactions-associated-Cyclosporine', 'Cyclosporine-associated-Drug-Related Side Effects and Adverse Reactions', 'Cyclosporine-minimize-Kidney Diseases', 'Diabetes Mellitus-exhibit-Insulin Lispro', 'Cyclosporine-represent-Hyperplasia', 'Neoplasms-reported-Cyclosporine', 'Ghrelin-associated-Weight Loss', 'Weight Loss-associated-Ghrelin', 'Enalapril-improve-Heart Failure', 'Osteoporosis-treated-Teriparatide', 'Glutathione-measure-Chronic Disease', 'Glutathione-induced-Chronic Disease', 'Liver Cirrhosis-induce-Glutathione', 'Octreotide-decrease-Sleep Wake Disorders', 'Glutathione-affected-Liver Cirrhosis', 'Octreotide-prompt-Sleep Wake Disorders', 'Enalapril-evaluated-Hypertension', 'Enalapril-tolerate-Hypertension', 'Death-provoked-Glutathione', 'Fibrosis-play-Bleomycin', 'Teriparatide-recommended-Fractures, Bone', 'Atazanavir Sulfate-worsen-Inflammation', 'Diabetes Insipidus-based-Glycopeptides', 'Prostatic Neoplasms-required-Glutathione', 'Enalapril-investigated-Death', 'Hypertension-conducted-Enalapril', 'Death-occur-Enalapril', 'Enalapril-contribute-Death', 'Glutathione-observed-Heredodegenerative Disorders, Nervous System', 'Abciximab-known-Acute Coronary Syndrome', 'Abciximab-reduce-Acute Coronary Syndrome', 'Vancomycin-make-Renal Insufficiency', 'Enalapril-compare-Hypertension', 'Glutathione-described-Alzheimer Disease', 'Glutathione-include-Neoplasms', 'Glutathione-up-regulated-Neoplasms', 'Ghrelin-mediated-Hypothalamic Neoplasms', 'Echinocandins-involve-Infections', 'Cataract-form-Glutathione', 'Bleomycin-administered-Neoplasms', 'Bleomycin-follow-Neoplasms', 'Vancomycin-treat-Infections', 'Arthritis, Infectious-receive-Vancomycin', 'Glutathione-protect-Mitochondrial Diseases', 'Alzheimer Disease-evaluate-Glutathione', 'Angiodysplasia-preferred-Octreotide', 'Enalapril-seem-Hypertension', 'Cyclosporine-correct-Mitochondrial Diseases', 'Cyclosporine-cause-Heart Arrest', 'Glutathione-elevated-Arthritis, Rheumatoid', 'Cyclosporine-receive-Graft vs Host Disease', 'Infections-appear-Vancomycin', 'Cyclosporine-inhibit-Hepatitis C', 'Enalapril-reduce-Dementia', 'Glutathione-stimulate-Alzheimer Disease', 'Ghrelin-demonstrate-Obesity', 'Thymic Factor, Circulating-determined-Alzheimer Disease', 'Ghrelin-attenuated-Obesity', 'Irritable Bowel Syndrome-discussed-Octreotide', 'Enalapril-suffer-Heart Failure', 'Cyclosporine-show-Drug-Related Side Effects and Adverse Reactions', 'Cataract-produced-Glutathione', 'Dry Eye Syndromes-encouraging-Cyclosporine', 'Cyclosporine-regarded-Arthritis, Rheumatoid', 'Cyclosporine-associated-Arthritis, Rheumatoid', 'Arthritis, Rheumatoid-associated-Cyclosporine', 'Glutathione-depleted-Death', 'Frailty-show-Glutathione', 'Dactinomycin-identified-Leukemia, Lymphocytic, Chronic, B-Cell', 'Dactinomycin-identify-Leukemia, Lymphocytic, Chronic, B-Cell', 'Fibrosis-apply-Bleomycin', 'Enalapril-reduce-Diabetes Mellitus, Type 1', 'Enalapril-produce-Hypotension', 'Hypoglycemia-treated-Octreotide', 'Thyrotropin-cause-Memory Disorders', 'Lisinopril-studied-Hypertension', 'Lisinopril-produce-Hypotension', 'Lisinopril-given-Hypertension', 'Cough-treated-Enalapril', 'Diabetic Neuropathies-restore-Glutathione', 'Drug-Related Side Effects and Adverse Reactions-associated-Glutathione', 'Glutathione-associated-Drug-Related Side Effects and Adverse Reactions', 'Glutathione-occur-Soft Tissue Injuries', 'Glutathione-determined-Polycystic Kidney Diseases', 'Glutathione-use-Polycystic Kidney Diseases', 'Thyrotropin-arise-Thyroid Diseases', 'Galactosemias-used-Glutathione', 'Streptogramins-offer-Infections', 'Vancomycin-prevent-Pneumococcal Infections', 'Infections-need-Glutathione', 'Parathyroid Hormone-known-Sarcopenia', 'Glutathione-live-Kashin-Beck Disease', 'Teriparatide-treat-Osteoporosis', 'Ghrelin-play-Glucose Metabolism Disorders', 'Glutathione-result-Pulmonary Arterial Hypertension', 'Vancomycin-determined-Kidney Diseases', 'Kidney Diseases-compare-Vancomycin', 'Psoriasis-treated-Cyclosporine', 'Bleomycin-develop-Fibrosis', 'Fibrosarcoma-reduce-Glutathione', 'Cyclosporine-improve-Kidney Diseases', 'Bleomycin-removed-Lung Diseases', 'Bleomycin-increase-Fibrosis', 'Lisinopril-observed-Hyperalgesia', 'Lisinopril-lead-Death', 'Invasive Fungal Infections-seem-Echinocandins', 'Pneumococcal Infections-use-Vancomycin', 'Arthritis, Rheumatoid-receive-Cyclosporine', 'Dipeptides-stabilize-Corneal Diseases', 'Glutathione-reduced-Diabetes Mellitus, Type 2', 'Osteoporosis-comprise-Teriparatide', 'Thyrotropin-rule-Hypothyroidism', 'Hypoglycemia-compare-Insulin Glargine', 'Hypoglycemia-observed-Insulin Glargine', 'Hypothyroidism-characterised-Thyrotropin', 'Cataract-show-Glutathione', 'Lisinopril-reduce-Cardiomyopathy, Hypertrophic', 'Lisinopril-reduce-Hypertension', 'Death-treated-Thyrotropin', 'Lisinopril-remain-Hypertension', 'Teriparatide-shown-Hypotension', 'Ghrelin-show-Metabolic Syndrome', 'Hypertension-induced-Cyclosporine', 'Enalapril-compared-Hypertension', 'Glutathione-identify-Drug-Related Side Effects and Adverse Reactions', 'Hypoxia-observed-Cyclosporine', 'Hypertension-controlled-Enalapril', 'Vancomycin-guide-Infections', 'Vancomycin-prescribed-Sepsis', 'Glutathione-exerted-Neurodegenerative Diseases', 'Glutathione-measure-Death', 'Infarction-treated-Abciximab', 'Abciximab-reduce-Hemorrhage', 'Abciximab-believed-Blood Platelet Disorders', 'Teriparatide-show-Osteoporosis', 'Infections-assess-Vancomycin', 'Pulmonary Fibrosis-induced-Bleomycin', 'Anemia-seen-Glutathione', 'Thyrotropin-predict-Hyperthyroidism', 'Amoxicillin-Potassium Clavulanate Combination-used-Liver Diseases', 'Lidocaine, Prilocaine Drug Combination-receive-Hyperalgesia', 'Trimethoprim, Sulfamethoxazole Drug Combination-treat-Haemophilus Infections', 'Pneumonia, Aspiration-selected-Piperacillin, Tazobactam Drug Combination', 'Trimethoprim, Sulfamethoxazole Drug Combination-induce-Meningitis, Aseptic', 'Meningitis, Aseptic-seen-Trimethoprim, Sulfamethoxazole Drug Combination', 'Trimethoprim, Sulfamethoxazole Drug Combination-show-Pneumonia, Pneumocystis', 'Infections-include-Trimethoprim, Sulfamethoxazole Drug Combination', 'Aminophylline-enhance-Diabetes Mellitus', 'Infections-treated-Amoxicillin-Potassium Clavulanate Combination', 'Nocardia Infections-initiated-Trimethoprim, Sulfamethoxazole Drug Combination', 'Chemical and Drug Induced Liver Injury-reported-Amoxicillin-Potassium Clavulanate Combination', 'Neoplasms-offer-Bevacizumab', 'Osteoporosis-receive-Denosumab', 'Infliximab-prevent-Alzheimer Disease', 'Denosumab-show-Osteoporosis', 'Psoriasis-include-Ustekinumab', 'Psoriasis-approved-Ustekinumab', 'Ustekinumab-update-Psoriasis', 'Ustekinumab-approved-Psoriasis', 'Ranibizumab-compare-Stroke', 'Infliximab-increase-Cataract', 'Rituximab-followed-Lymphoma, Mantle-Cell', 'Denosumab-reduce-Pain', 'Trastuzumab-know-Breast Neoplasms', 'Breast Neoplasms-exposed-Trastuzumab', 'Trastuzumab-increase-Breast Neoplasms', 'Colorectal Neoplasms-derive-Bevacizumab', 'Infliximab-involved-Alzheimer Disease', 'Infliximab-differ-Alzheimer Disease', 'Cetuximab-enhance-Drug-Related Side Effects and Adverse Reactions', 'Neoplasms-compared-Checkpoint Kinase 1', 'Neoplasms-enhance-Bevacizumab', 'Infliximab-impair-Alzheimer Disease', 'Alzheimer Disease-linked-Infliximab', 'Glioblastoma-use-Bevacizumab', 'Alzheimer Disease-target-Infliximab', 'Palivizumab-indicated-Infections', 'Rituximab-prolong-Lymphoma, Mantle-Cell', 'Infliximab-altered-Progeria', 'Neoplasms-increase-Infliximab', 'Muscle Hypotonia-induce-Infliximab', 'Denosumab-administered-Osteoporosis', 'Denosumab-treated-Osteoporosis', 'Denosumab-treat-Osteoporosis', 'Fractures, Bone-reported-Denosumab', 'Rituximab-show-Hodgkin Disease', 'Pneumonia-treated-Nivolumab', 'Colorectal Neoplasms-encourage-Bevacizumab', 'Bevacizumab-improve-Colorectal Neoplasms', 'Colorectal Neoplasms-improve-Bevacizumab', 'Rituximab-approved-Neoplasms', 'Rituximab-combine-Drug-Related Side Effects and Adverse Reactions', 'Infliximab-reduced-Alzheimer Disease', 'Rituximab-revolutionize-Lymphoma', 'Retinal Diseases-occur-Ipilimumab', 'Trastuzumab-needed-Heart Failure', 'Hypertension-include-Bevacizumab', 'Bevacizumab-lead-Breast Neoplasms', 'Bevacizumab-include-Breast Neoplasms', 'Infliximab-decreased-Alzheimer Disease', 'Rituximab-increase-Mycoses', 'Fractures, Bone-follow-Denosumab', 'Fractures, Bone-reduce-Denosumab', 'Fractures, Bone-understand-Denosumab', 'Trastuzumab-address-Cardiotoxicity', 'Alzheimer Disease-show-Infliximab', 'Drug-Related Side Effects and Adverse Reactions-alter-Infliximab', 'Infliximab-resemble-Alzheimer Disease', 'Infections-prevent-Palivizumab', 'Arthritis, Rheumatoid-treated-Rituximab', 'Rituximab-change-Thrombocytopenia', 'Rituximab-associated-Hepatitis B', 'Hepatitis B-associated-Rituximab', 'Omalizumab-approved-Urticaria', 'Ustekinumab-required-Crohn Disease', 'Ulcer-treated-Checkpoint Kinase 1', 'Brain Diseases-associated-Bevacizumab', 'Bevacizumab-associated-Brain Diseases', 'Infliximab-show-Alzheimer Disease', 'Alzheimer Disease-accumulate-Infliximab', 'Infliximab-determined-Death', 'Infliximab-afford-Neurotoxicity Syndromes', 'Omalizumab-reduce-Asthma', 'Rituximab-limited-Leukemia, Lymphocytic, Chronic, B-Cell', 'Arthritis, Rheumatoid-followed-Infliximab', 'Huntington Disease-followed-Rituximab', 'Infliximab-contribute-Alzheimer Disease', 'Multiple Sclerosis-materialize-Rituximab', 'Infections-treated-Rituximab', 'Trastuzumab-identified-Neoplasms', 'Bevacizumab-receive-Breast Neoplasms', 'Bevacizumab-tolerated-Neutropenia', 'Infections-follow-Rituximab', 'Death, Sudden, Cardiac-occur-Infliximab', 'Bevacizumab-found-Neoplasm Metastasis', 'Bisphosphonate-Associated Osteonecrosis of the Jaw-occur-Denosumab', 'Wounds and Injuries-assessed-Infliximab', 'Infliximab-limit-Fibrosis', 'Lymphoma, Mantle-Cell-based-Rituximab', 'Denosumab-reduce-Osteolysis', 'Rituximab-result-Agammaglobulinemia', 'Necrosis-cause-Infliximab', 'Palivizumab-intended-Infections', 'Adalimumab-induce-Neoplasms', 'Colorectal Neoplasms-added-Bevacizumab', 'Infliximab-described-Alzheimer Disease', 'Rituximab-become-Hemophilia A', 'Retinal Degeneration-receive-Ranibizumab', 'Rituximab-added-Drug-Related Side Effects and Adverse Reactions', 'Hypotension-result-Infliximab', 'Infliximab-review-Renal Insufficiency, Chronic', 'Rituximab-enlarged-Neoplasms', 'Infliximab-disrupted-Osteoporosis', 'Drug-Related Side Effects and Adverse Reactions-compare-Rituximab', 'Infections-remain-Palivizumab', 'Infliximab-contribute-Muscle Weakness', 'Infliximab-provide-Malignant Hyperthermia', 'Infliximab-reported-Alzheimer Disease', 'Denosumab-introduced-Osteoporosis', 'Denosumab-prevent-Fractures, Bone', 'Cetuximab-test-Carcinoma, Non-Small-Cell Lung', 'Purpura, Thrombocytopenic, Idiopathic-treated-Rituximab', 'Purpura, Thrombocytopenic, Idiopathic-use-Rituximab', 'Ranibizumab-result-Vision Disorders', 'Heart Diseases-receive-Trastuzumab', 'Ranibizumab-approved-Glycogen Storage Disease Type II', 'Infliximab-determined-Alzheimer Disease', 'Glioma-clarify-Bevacizumab', 'Lipopolysaccharides-lead-Death', 'Drug-Related Side Effects and Adverse Reactions-compare-Ibotenic Acid', 'Pulmonary Disease, Chronic Obstructive-use-Lipopolysaccharides', 'Lipopolysaccharides-reduced-Encephalomyelitis, Autoimmune, Experimental', 'Vaginosis, Bacterial-known-Lipopolysaccharides', 'Vaginosis, Bacterial-produce-Lipopolysaccharides', 'Aflatoxin B1-metabolize-Carcinogenesis', 'Neuroblastoma-treated-Lipopolysaccharides', 'Carcinogenesis-include-Aflatoxins', 'Uveitis-administer-Lipopolysaccharides', 'Drug-Related Side Effects and Adverse Reactions-observed-Lipopolysaccharides', 'Lipopolysaccharides-overrepresented-Sarcopenia', 'Lipopolysaccharides-associated-Sarcopenia', 'Sarcopenia-associated-Lipopolysaccharides', 'Lipopolysaccharides-influence-Neurodegenerative Diseases', 'Lipopolysaccharides-precipitate-Periodontitis', 'Shock, Septic-caused-Lipopolysaccharides', 'Lipopolysaccharides-induce-Necrosis', 'rs4149573-alter-Coronary Artery Disease', 'rs33912345-associated-Glaucoma, Open-Angle', 'Glaucoma, Open-Angle-associated-rs33912345', 'Alzheimer Disease-carry-rs63750064', 'rs63750064-recapitulate-Alzheimer Disease', 'rs1333049-compare-Coronary Artery Disease', 'rs1346044-associated-Cataract', 'Cataract-associated-rs1346044', 'rs56149945-genotyped-Cardiovascular Diseases', 'rs34166160-associated-Cerebral Infarction', 'Cerebral Infarction-associated-rs34166160', 'rs5882-associated-Aneurysm', 'Aneurysm-associated-rs5882', 'rs11235972-show-Death', 'rs113488022-characterized-Colonic Neoplasms', 'Aortic Aneurysm, Abdominal-compare-rs1801133', 'rs58912633-characterized-Muscular Dystrophies', 'rs1800795-associated-Infarction', 'Infarction-associated-rs1800795', 'rs308442-correlated-Osteoporosis', 'rs1801133-study-Dementia', 'rs143624519-augment-Neurodegenerative Diseases', 'rs984395300-associated-Inflammation', 'Inflammation-associated-rs984395300', 'rs2618516-affect-Dementia', 'rs2420915-promote-Pulmonary Disease, Chronic Obstructive', 'rs6430491-linked-Pulmonary Disease, Chronic Obstructive', 'rs60310264-cause-Progeria', 'rs104893877-over-expressing-Weight Loss', 'rs5744455-associated-Neoplasms', 'Neoplasms-associated-rs5744455', 'rs2273773-carry-Hyperglycemia', 'rs2383207-implicate-Stroke', 'rs2829887-associated-Plaque, Amyloid', 'Plaque, Amyloid-associated-rs2829887', 'rs7963551-exhibit-Death', 'rs11552449-associated-Breast Neoplasms', 'Breast Neoplasms-associated-rs11552449', 'rs632793-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-rs632793', 'rs1800544-detected-Osteoporosis', 'rs1800544-associated-Osteoporotic Fractures', 'Osteoporotic Fractures-associated-rs1800544', 'rs4130113-tested-Death', 'Alzheimer Disease-suggested-rs1799945', 'rs2814778-protect-Malaria', 'rs1799945-anticipate-Alzheimer Disease', 'rs3745369-associated-Obesity', 'Obesity-associated-rs3745369', 'rs3745367-associated-Obesity', 'Obesity-associated-rs3745367', 'rs17185536-identify-Erectile Dysfunction', 'rs1999805-associated-Muscular Dystrophy, Duchenne', 'Muscular Dystrophy, Duchenne-associated-rs1999805', 'rs2665802-associated-Sleep Initiation and Maintenance Disorders', 'Sleep Initiation and Maintenance Disorders-associated-rs2665802', 'Progeria-carry-rs58596362', 'Epilepsy-caused-rs796053228', 'rs764254110-test-Parkinson Disease', 'rs1333049-genotype-Coronary Artery Disease', 'rs28940578-find-Coronary Artery Disease', 'rs9536314-protect-Breast Neoplasms', 'rs28940578-develop-Myocardial Infarction', 'Myocardial Infarction-predict-rs28940578', 'rs10137185-associated-Alzheimer Disease', 'Alzheimer Disease-associated-rs10137185', 'rs1256059-associated-Alzheimer Disease', 'Alzheimer Disease-associated-rs1256059', 'rs4988235-determine-Hypertension', 'rs696217-associated-Obesity', 'Obesity-associated-rs696217', 'rs3918242-lead-Aneurysm', 'rs3918242-associated-Carcinoma, Squamous Cell', 'Carcinoma, Squamous Cell-associated-rs3918242', 'Weight Gain-noted-rs75527207', 'rs1346044-associated-Neoplasms', 'Neoplasms-associated-rs1346044', 'rs401681-associated-Neoplasms', 'Neoplasms-associated-rs401681', 'rs2004776-associated-Hypertension', 'Hypertension-associated-rs2004776', 'rs63750847-contribute-Alzheimer Disease', 'rs63750847-confer-Alzheimer Disease', 'rs1207568-associated-Coronary Artery Disease', 'Coronary Artery Disease-associated-rs1207568', 'rs2971609-lie-Migraine Disorders', 'rs121918339-segregate-Deafness', 'rs7503726-associated-Alzheimer Disease', 'Alzheimer Disease-associated-rs7503726', 'rs12470143-associated-Metabolic Syndrome', 'Metabolic Syndrome-associated-rs12470143', 'rs9998212-show-Atrophy', 'rs12252-measured-Infections', 'rs2970848-associated-Parkinson Disease', 'Parkinson Disease-associated-rs2970848', 'rs6821591-associated-Parkinson Disease', 'Parkinson Disease-associated-rs6821591', 'Neoplasms-decreased-rs1801133', 'rs2208454-associated-Infarction', 'Infarction-associated-rs2208454', 'rs28365927-increase-Non-alcoholic Fatty Liver Disease', 'rs63750424-recapitulate-Alzheimer Disease', 'rs118192162-associated-Myopathy, Central Core', 'Myopathy, Central Core-associated-rs118192162', 'rs63751273-associated-Mitochondrial Diseases', 'Mitochondrial Diseases-associated-rs63751273', 'rs12425791-associated-Cerebral Infarction', 'Cerebral Infarction-associated-rs12425791', 'rs188286943-linked-Mitochondrial Diseases', 'Osteoporosis-carry-rs4988300', 'Alzheimer Disease-found-rs3810950', 'rs3810950-associated-Alzheimer Disease', 'Alzheimer Disease-associated-rs3810950', 'rs63751273-show-Tauopathies', 'rs63750424-contain-Plaque, Amyloid', 'rs2811712-compare-Hyperlipidemias', 'rs4747096-extracted-Osteoarthritis', 'rs7078012-associated-Pulmonary Disease, Chronic Obstructive', 'Pulmonary Disease, Chronic Obstructive-associated-rs7078012', 'rs17081935-affected-Atherosclerosis', 'rs2076260-test-Death', 'rs3027178-show-Alzheimer Disease', 'Alzheimer Disease-associated-rs2300403', 'rs2300403-associated-Alzheimer Disease', 'Hemochromatosis-fail-rs1800562', 'rs7038172-associated-Dementia', 'Dementia-associated-rs7038172', 'rs104893877-mimic-Parkinson Disease', 'rs1801155-detected-Neoplasms', 'rs1800629-confer-Neurologic Manifestations', 'Death-exhibit-rs9384680', 'rs104893877-result-Death', 'Osteosarcoma-carry-rs59267781', 'rs5882-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-rs5882', 'Atherosclerosis-increase-ERCC4', 'BMP2-activate-TFRC', 'BMP2-ameliorate-Wounds and Injuries', 'Wounds and Injuries-activate-TFRC', 'Wounds and Injuries-regulate-TFRC', 'Memory Disorders-cause-Learning Disabilities', 'MSI1-result-Memory Disorders', 'MSI1-cause-Learning Disabilities', 'MSI2-result-Memory Disorders', 'MSI2-cause-Learning Disabilities', 'LRP1B-contain-RGS6', 'rs11679458-contain-rs11848300', 'LRP1B-contain-rs11679458', 'LRP1B-contain-rs11848300', 'RGS6-contain-rs11848300', 'ALB-assessed-Myoclonic Epilepsies, Progressive', 'CST3-assessed-Myoclonic Epilepsies, Progressive', 'CRP-assessed-Myoclonic Epilepsies, Progressive', 'Glucose-assessed-Myoclonic Epilepsies, Progressive', 'INS-measured-ADIPOQ', 'LEP-measured-ADIPOQ', 'FGF21-measured-ADIPOQ', 'Inflammation-measured-ADIPOQ', 'TERT-classified-PIK3CA', 'TERT-classified-TP53', 'TERT-classified-EGFR', 'TERT-classified-Oculocerebrorenal Syndrome', 'DDIT3-be in-CD34', 'Myelodysplastic Syndromes-be with-Anemia', 'SLC5A2-compare-DPP4', 'DPP4-associated-Dementia', 'Dementia-associated-DPP4', 'INS-enhance-GCG', 'GCG-facilitate-INS', 'Glucose-enhance-GCG', 'GCG-facilitate-Glucose', 'MAPT-mediate-Atrophy', 'GFAP-mediate-Atrophy', 'TNFSF12-reveal-HGF', 'TNFSF12-reveal causal associations with-Sarcopenia', 'Sarcopenia-reveal-HGF', 'Myoclonus-underlie-Neoplasms', 'PRKAA2-inhibited-INS', 'GALR2-treat-Diabetic Cardiomyopathies', 'Tremor-underlie-Neoplasms', 'EN1-used-Parkinson Disease', 'LOXL1-used-Parkinson Disease', 'EN1-identified-Parkinson Disease', 'Movement Disorders-underlie-Neoplasms', 'Syringomyelia-underlie-Neoplasms', 'Myoclonus-small group of-LGI1', 'Movement Disorders-small group of-LGI1', 'PRKAA2-inhibited-Inflammation', 'MTOR-lead-rs63750424', 'Myoclonus-small group of-CNTNAP2', 'PRKAA2-inhibited-Diabetes Mellitus', 'PRKAA2-inhibited-Neoplasms', 'Movement Disorders-patients with-CNTNAP2', 'Movement Disorders-small group of-CNTNAP2', 'PRKAA2-inhibited-Obesity', 'APOE-found-PSEN2', 'APOE-found-rs771375988', 'Alzheimer Disease-found-PSEN2', 'APOE-be common in-Alzheimer Disease', 'Alzheimer Disease-found-rs771375988', 'INS-be in-Amyloidosis', 'CCL19-up-regulate-CPLX2', 'AKT1-act-Alzheimer Disease', 'INS-act-Alzheimer Disease', 'FABP7-up-regulate-CPLX2', 'S100B-up-regulate-CPLX2', 'SEZ6-up-regulate-CPLX2', 'SPIB-up-regulate-CPLX2', 'CTSW-up-regulate-CPLX2', 'CXCL1-up-regulate-CPLX2', 'CCL19-identified-Neoplasms', 'FABP7-identified-Neoplasms', 'FABP7-down-regulate-Neoplasms', 'S100B-identified-Neoplasms', 'S100B-down-regulate-Neoplasms', 'SEZ6-identified-Neoplasms', 'SEZ6-down-regulate-Neoplasms', 'SPIB-identified-Neoplasms', 'SPIB-down-regulate-Neoplasms', 'Heparitin Sulfate-include-Kidney Diseases', 'CTSW-identified-Neoplasms', 'CTSW-down-regulate-Neoplasms', 'Heparitin Sulfate-ascribed-Glomerulonephritis', 'Neoplasms-up-regulate-CPLX2', 'CPLX2-up-regulate-Phenylketonurias', 'CXCL1-identified-Neoplasms', 'CXCL1-down-regulate-Neoplasms', 'rs401681-be in-TERT', 'rs401681-be in-CLPTM1', 'Alzheimer Disease-observed-PTPN5', 'Lung Neoplasms-focus-Neoplasms', 'GGH-bind-GHR', 'Lung Neoplasms-focus-Sarcoma', 'Neoplasms-focus-Sarcoma', 'LEP-compare-Obesity', 'LEP-characterize-Obesity', 'ADIPOQ-characterize-Obesity', 'Lung Neoplasms-focus-PDCD1', 'GHR-inhibit-Pulmonary Atresia', 'Neoplasms-focus-PDCD1', 'ALB-compare-Obesity', 'ALB-characterize-Obesity', 'GGH-inhibit-Pulmonary Atresia', 'Lung Neoplasms-focus-EGFR', 'Neoplasms-focus-EGFR', 'NFKB1-decrease-NR3C2', 'Lung Neoplasms-focus-ALK', 'Sepsis-upregulated-Inflammation', 'NR3C2-decrease-Fibrosis', 'NR3C2-implicated-Fibrosis', 'Sepsis-upregulated-FCER1A', 'NFKB1-decrease-Fibrosis', 'NFKB1-implicated-Fibrosis', 'Neoplasms-focus-ALK', 'Sepsis-upregulated-ALOX15', 'Sepsis-upregulated-PCSK9', 'Olfaction Disorders-associated-NEFL', 'NEFL-associated-Olfaction Disorders', 'Olfaction Disorders-associated-MAPT', 'MAPT-associated-Olfaction Disorders', 'ABCB1-of Genotyping be-ABCC1', 'FOLR2-play-Inflammation', 'SOD2-be in-Glioma', 'SIRT5-take-Glioma', 'SIRT5-take-Epilepsy', 'DANCR-bind-TP53', 'DANCR-binding of-HNRNPC', 'DANCR-bind with-HNRNPC', 'DANCR-attenuate-HNRNPC', 'DANCR-bind-HNRNPC', 'GLUD1-take-Epilepsy', 'SIRT4-take-Glioma', 'SIRT4-take-Epilepsy', 'SOD1-take-Epilepsy', 'SIRT3-take-Glioma', 'SIRT3-take-Epilepsy', 'SOD2-take-Epilepsy', 'Fibrosis-human atrial fibroblasts-EP300', 'Fibrosis-left tissues-EP300', 'Fibrosis-tissues-EP300', 'Fibrosis-left atrial tissues-EP300', 'Osteoporotic Fractures-upregulated-XCL1', 'Osteoporotic Fractures-upregulated-CCL5', 'Osteoporotic Fractures-upregulated-CCL7', 'Osteoporotic Fractures-upregulated-ITGA1', 'HMOX1-upregulated-Osteoporotic Fractures', 'Osteoporotic Fractures-upregulated-TBX21', 'Osteoporotic Fractures-upregulated-CXCL10', 'EGFR-upregulated-Osteoporotic Fractures', 'PGR-upregulated-Osteoporotic Fractures', 'Osteoporotic Fractures-upregulated-IL12B', 'Atherosclerosis-harbor-Neoplasms', 'Atherosclerosis-validate-CDKN2A', 'Neoplasms-harbor-CDKN2A', 'Atherosclerosis-validate-CDKN2B', 'Neoplasms-harbor-CDKN2B', 'CUX1-be transcriptional activator of-CDKN2A', 'CUX1-be transcriptional activator via-rs1537371', 'CUX1-be transcriptional activator via-Atherosclerosis', 'SATB2-be transcriptional suppressor unlike-CUX1', 'SATB2-be transcriptional suppressor of-CDKN2A', 'CUX1-compete-rs1537371', 'CDKN2A-inhibit-rs1537371', 'CUX1-downregulate-SATB2', 'Atherosclerosis-downregulate-SATB2', 'SATB2-upregulation of-CUX1', 'SATB2-enhance-CUX1', 'SATB2-inhibit-CUX1', 'CUX1-inhibit-CDKN2A', 'rs1537371-enhance-SATB2', 'Chronic Disease-linked-Diabetes Mellitus', 'Chronic Disease-linked-Fatty Liver', 'Chronic Disease-linked-Coronary Artery Disease', 'Chronic Disease-linked-Stroke', 'Chronic Disease-linked-Renal Insufficiency, Chronic', 'Fatty Acids, Omega-3-enhance-Myalgia', 'Fatty Acids, Unsaturated-tend-Ceramides', 'Glycerophospholipids-tend-Ceramides', 'Ceramides-decreased-SIRT6', 'Ceramides-tend-SIRT6', 'Fatty Acids, Unsaturated-decreased-SIRT6', 'Glycerophospholipids-decreased-SIRT6', 'Ceramides-decreased-rs201141490', 'Ceramides-tend-rs201141490', 'Ceramides-decreased-rs183444295', 'Ceramides-tend-rs183444295', 'SIRT6-suppress-Neoplasms', 'rs174537-associated-rs953413', 'rs953413-associated-rs174537', 'rs174537-associated-Linoleic Acids', 'Linoleic Acids-associated-rs174537', 'Linoleic Acids-associated-rs953413', 'rs953413-associated-Linoleic Acids', 'Inflammation-described-Obesity', 'Inflammation-control-Obesity', 'Inflammation-described-Diabetes Mellitus', 'Inflammation-control-Diabetes Mellitus', 'FNDC5-described-Obesity', 'FNDC5-include-Obesity', 'FNDC5-control-Obesity', 'FNDC5-described-Diabetes Mellitus', 'FNDC5-include-Diabetes Mellitus', 'FNDC5-control-Diabetes Mellitus', 'Sarcopenia-associated-Atrophy', 'Atrophy-associated-Sarcopenia', 'Sarcopenia-result-Atrophy', 'Hypertension-take-Glucose', 'Glucose-take-Diabetes Mellitus', 'Triglycerides-take-Hypertension', 'Triglycerides-take-Diabetes Mellitus', 'CNR2-portray-Colorectal Neoplasms', 'Tauopathies-characterized-Astrocytoma', 'MAPT-characterized-Astrocytoma', 'Obesity-mice with-Diabetes Mellitus', 'Obesity-stressed-Diabetes Mellitus', 'Obesity-stressed-Streptozocin', 'Osteogenesis Imperfecta-ameliorate-Osteoporosis', 'Drug-Related Side Effects and Adverse Reactions-lead-Respiratory Insufficiency', 'ACHE-lead-Death', 'ACHE-lead-Respiratory Insufficiency', 'Pulmonary Fibrosis-support-Digoxin', 'Alzheimer Disease-support-Digoxin', 'Arthritis-support-Digoxin', 'Atherosclerosis-support-Digoxin', 'Esophageal Neoplasms-impede-Carcinogenesis', 'MTNR1B-identify-Atherosclerosis', 'MTNR1B-combine-Atherosclerosis', 'NOTCH1-occupy-Esophageal Neoplasms', 'MTNR1B-identify-Hypertension', 'NOTCH1-impede-Carcinogenesis', 'Tauopathies-associated-Frontotemporal Lobar Degeneration', 'Frontotemporal Lobar Degeneration-associated-Tauopathies', 'Tauopathies-express-rs63751438', 'NOTCH1-be prevalent In-Carcinogenesis', 'NOTCH1-be prevalent in-Neoplasms', 'rs63751438-associated-Frontotemporal Lobar Degeneration', 'Frontotemporal Lobar Degeneration-associated-rs63751438', 'Atrial Fibrillation-exert-Digoxin', 'Heart Failure-exert-Digoxin', 'Diabetes Mellitus-related-TLR4', 'Diabetes Mellitus-achieve-Cardiovascular Diseases', 'Diabetes Mellitus-achieve-Glucose', 'Venous Thrombosis-simplify-Pulmonary Embolism', 'Heart Diseases-reduce-Glucose', 'Hyperkinesis-cause-Hyperpigmentation', 'Obesity-reduce-Glucose', 'TYR-cause-Hyperpigmentation', 'TYR-triggered-Inflammation', 'TRE-TTC3-1-ameliorate-Obesity', 'TRE-TTC3-1-ameliorate-Metabolic Diseases', 'Hydrocephalus-require-Encephalocele', 'Gentamicins-require-Hydrocephalus', 'Anthocyanins-associated-Death', 'Death-associated-Anthocyanins', 'Anthocyanins-associated-Coronary Artery Disease', 'Coronary Artery Disease-associated-Anthocyanins', 'Anthocyanins-associated-Cerebrovascular Disorders', 'Cerebrovascular Disorders-associated-Anthocyanins', 'Anthocyanins-associated-Peripheral Arterial Disease', 'Peripheral Arterial Disease-associated-Anthocyanins', 'Inflammation-implicated-Non-alcoholic Fatty Liver Disease', 'SIRT6-implicated-Inflammation', 'SIRT6-implicated-Non-alcoholic Fatty Liver Disease', 'Fibrosis-reduce-Kidney Diseases', 'Fibrosis-Inhibition of-PDIA3', 'Fibrosis-reduce-PDIA3', 'PDIA3-reduce-Kidney Diseases', 'Diabetes Mellitus-prevalence of-Osteoporosis', 'Blood Coagulation Disorders-disturbed-Thrombophilia', 'Dementia-be in-Diabetes Mellitus', 'Thrombophilia-disturbed-Protein C Deficiency', 'Dementia-reduce-SPP1', 'Diabetes Mellitus-reduce-SPP1', 'Blood Coagulation Disorders-disturbed-Protein C Deficiency', 'Thrombophilia-disturbed-rs1799963', 'von Willebrand Disease, Type 3-be with-VWF', 'VWF-require-Hemorrhage', 'Blood Coagulation Disorders-disturbed-rs1799963', 'Heart Failure-play-NLRP3', 'NLRP3-involved-Obesity', 'NLRP3-play-Inflammation', 'NLRP3-involved-Inflammation', 'NLRP3-involved-Heart Failure', 'Progeria-elicit-Drug-Related Side Effects and Adverse Reactions', 'Aging, Premature-elicit-Drug-Related Side Effects and Adverse Reactions', 'Neoplasms-be in-Carcinoma, Hepatocellular', 'KL-known-Carcinoma, Hepatocellular', 'KL-act-Carcinoma, Hepatocellular', 'LMNA-elicit-Drug-Related Side Effects and Adverse Reactions', 'Ocular Hypertension-interact-Hypertension', 'GLP1R-use-Neurodegenerative Diseases', 'APOE-interact with-Hypertension', 'GLP1R-use-Alzheimer Disease', 'GLP1R-use-Parkinson Disease', 'Inflammation-mark-CRP', 'Heart Injuries-result-Diabetic Cardiomyopathies', 'Diabetes Mellitus-result-Diabetic Cardiomyopathies', 'Heart Injuries-result-INS', 'Alzheimer Disease-characterized-Frontotemporal Lobar Degeneration', 'Alzheimer Disease-characterized-Pneumothorax', 'QPCT-linked-Alzheimer Disease', 'Frontotemporal Lobar Degeneration-exemplified-Supranuclear Palsy, Progressive', 'Frontotemporal Lobar Degeneration-exemplified-Pneumothorax', 'Frontotemporal Lobar Degeneration-characterized-MAPT', 'Frontotemporal Lobar Degeneration-include-Neurodegenerative Diseases', 'Frontotemporal Lobar Degeneration-include-MAPT', 'Inflammation-promote-Renal Insufficiency, Chronic', 'Heart Failure-be with-Kidney Diseases', 'Inflammation-promote-EIF2AK3', 'Digoxin-assessed-Heart Failure', 'Critical Illness-receive-Bacterial Infections', 'Critical Illness-receive-Polymyxin B', 'Polymyxin B-receive-Bacterial Infections', 'Metabolic Diseases-correlated-Alzheimer Disease', 'Inflammation-correlated-Alzheimer Disease', 'Neurodegenerative Diseases-distinguish-Pneumothorax', 'Glucose Intolerance-correlated-Alzheimer Disease', 'Neuroaxonal Dystrophies-associated-Pneumothorax', 'Pneumothorax-associated-Neuroaxonal Dystrophies', 'Neuroaxonal Dystrophies-distinguish-Pneumothorax', 'Neuroaxonal Dystrophies-associated-MAPT', 'MAPT-associated-Neuroaxonal Dystrophies', 'MAPT-distinguish-Pneumothorax', 'INS-correlated-Alzheimer Disease', 'Dementia-develop-Memory Disorders', 'Mitochondrial Diseases-lowering-Inflammation', 'Renal Insufficiency, Chronic-be with-Immunologic Deficiency Syndromes', 'KL-decreases during-Acute Kidney Injury', 'Renal Insufficiency, Chronic-be with-KL', 'Mitochondrial Diseases-lowering-Fibrosis', 'Obesity-complicated-Diabetes Mellitus', 'Obesity-complicated-INS', 'Mitochondrial Diseases-reinforce-INS', 'Inflammation-reinforce-INS', 'Fibrosis-reinforce-INS', 'Diabetes Mellitus-have change from-Death', 'CTSF-implicated-Dermatitis', 'Diabetes Mellitus-have change from-Chronic Disease', 'CTSF-implicated-Neoplasms', 'Death-change-Chronic Disease', 'Diabetes Mellitus-have change In-INS', 'FGF21-protect-Obesity', 'FGF21-protect-Diabetes Mellitus', 'INS-change-Death', 'FGF21-involved-Cardiomegaly', 'INS-change-Chronic Disease', 'FGF21-involved-Inflammation', 'TARDBP-diagnosed-Alzheimer Disease', 'rs80356740-diagnosed-Alzheimer Disease', 'Inflammation-associate-Sarcopenia', 'Sarcopenia-associate-Inflammation', 'Movement Disorders-observe-Myoclonus', 'Movement Disorders-be in-CNTNAP2', 'Endocrine System Diseases-associate-Sarcopenia', 'Sarcopenia-associate-Endocrine System Diseases', 'Chronic Disease-associate-Sarcopenia', 'Sarcopenia-associate-Chronic Disease', 'Movement Disorders-be prevalent in-CNTNAP2', 'Ataxia-be prevalent in-CNTNAP2', 'Encephalitis-include-CNTNAP2', 'Syringomyelia-include-CNTNAP2', 'INS-associate-Sarcopenia', 'Sarcopenia-associate-INS', 'Peripheral Nervous System Diseases-include-CNTNAP2', 'Ataxia-include-CNTNAP2', 'Pain-include-CNTNAP2', 'Gliosis-underpin-Obesity', 'Sleep Wake Disorders-include-CNTNAP2', 'DYRK1A-play-Brain Diseases', 'DYRK1A-play-Neurodegenerative Diseases', 'DYRK1A-play-Nerve Degeneration', 'DYRK1A-overexpress-Dementia', 'Chemical and Drug Induced Liver Injury-cause-Fibrosis', 'PRMT5-cause-Fibrosis', 'Glucose-prevent-Intervertebral Disc Degeneration', 'INS-associated-Kidney Diseases', 'Kidney Diseases-associated-INS', 'INS-associated-Renal Insufficiency', 'Renal Insufficiency-associated-INS', 'Diabetes Mellitus-linked-INS', 'Progeria-regulated-Atherosclerosis', 'NFE2L2-postpon-Progeria', 'Kidney Diseases-linked-INS', 'Metabolic Syndrome-divide-Hypertension', 'Metabolic Syndrome-divide-Obesity, Abdominal', 'Metabolic Syndrome-fail-Obesity, Abdominal', 'ADIPOQ-lead to-INS', 'INHBE-involved-FST', 'MAPK8-decrease-JUN', 'MAPK1-decrease-MAPK8', 'MAPK1-decrease-JUN', 'CD8A-result-IL17A', 'CD4-result-IL17A', 'MMP2-required-MMP14', 'TIMP2-required-MMP2', 'TIMP2-inhibit-MMP2', 'TIMP2-required-MMP14', 'CDK2-enhance-CDK4', 'SART1-bind-UBL5', 'CDK2-enhance-BCL2', 'ITGB2-interact-ICAM1', 'PORCN-associated-APOE', 'APOE-associated-PORCN', 'ADAM22-reduce-EGR2', 'ADAM22-reduce-PRX', 'TP53-phosphorylate-MAPK14', 'ATM-inhibit-TP53', 'ATM-inhibit-MAPK14', 'CDKN2A-phosphorylate-MAPK14', 'MAPK14-phosphorylate-MAPK8', 'ATM-inhibit-CDKN2A', 'ATM-inhibit-MAPK8', 'ACLY-associated-SQSTM1', 'SQSTM1-associated-ACLY', 'METTL14-result-LBR', 'CYBB-appear-NOX4', 'SIRT6-enhance-F3', 'BHLHE40-associated-EIF5A2', 'EIF5A2-associated-BHLHE40', 'RHOXF1-associated-EIF5A2', 'EIF5A2-associated-RHOXF1', 'FYN-known-PTPN5', 'ACHE-compare-BCHE', 'ACHE-inhibited-BCHE', 'CDKN2A-show-CDKN1A', 'HECTD1-bind-RUBCN', 'TAT-promote-RMDN3', 'TAT-prevent-VAPB', 'RMDN3-prevent-VAPB', 'TP53-form-SMAD3', 'MAPK8-upregulate-FTO', 'HK2-upregulated-EXO1', 'PFKP-upregulated-EXO1', 'DNMT3B-reveal-STAT3', 'SATB2-repressed-CUX1', 'STAT3-increase-DNMT3B', 'Fatty Acids, Omega-3-reduce-Triglycerides', 'Fatty Acids, Omega-3-increase-Cholesterol', 'rs11189312-associated-rs10882883', 'rs10882883-associated-rs11189312', 'rs11189312-associated-rs17108378', 'rs17108378-associated-rs11189312', 'rs11189312-associated-rs35077384', 'rs35077384-associated-rs11189312', 'Infections-cause-Hearing Loss, Central', 'Hearing Loss, Central-known-Hearing Loss', 'Obesity-shown-Alzheimer Disease', 'Obesity-defined-Obesity, Abdominal', 'Atrial Fibrillation-use-CHARGE Syndrome', 'Dystonia-associated-Death', 'Death-associated-Dystonia', 'Angina Pectoris-include-Communicable Diseases', 'Nervous System Diseases-assess-Arteriolosclerosis', 'Nervous System Diseases-assess-Atherosclerosis', 'Lung Diseases-include-Communicable Diseases', 'Arthritis-include-Communicable Diseases', 'Cataract-include-Communicable Diseases', 'Nervous System Diseases-assess-Cerebral Amyloid Angiopathy', 'Nervous System Diseases-assess-Alzheimer Disease', 'Nervous System Diseases-assess-Plaque, Amyloid', 'Nervous System Diseases-assess-Sclerosis', 'Nervous System Diseases-assess-Brain Diseases', 'Dementia-assess-Arteriolosclerosis', 'Dementia-assess-Atherosclerosis', 'Dementia-assess-Cerebral Amyloid Angiopathy', 'Dementia-Establish-Plaque, Amyloid', 'Dementia-Establish-Sclerosis', 'Dementia-Establish-Brain Diseases', 'Hantavirus Pulmonary Syndrome-swallow-Deglutition Disorders', 'Neurologic Manifestations-use-Death', 'Neurologic Manifestations-show-Death', 'Fractures, Bone-include-Chronic Disease', 'Sepsis-characterised-Infections', 'Alzheimer Disease-involve-Memory Disorders', 'Disease-involve-Neurodegenerative Diseases', 'Disease-involve-Memory Disorders', 'Adrenal Insufficiency-increase-Sarcopenia', 'Sarcopenia-increase-Carcinoma, Hepatocellular', 'Death-increase-Carcinoma, Hepatocellular', 'Chemical and Drug Induced Liver Injury-regenerated-Chronic Disease', 'Death-undergo-Acute Coronary Syndrome', 'Stroke-concerned-Hemorrhage', 'Renal Insufficiency, Chronic-carried-Liver Failure', 'Glaucoma-develop-Vision Disorders', 'Neoplasms-form-Severe Combined Immunodeficiency', 'Neoplasms-form-X-Linked Combined Immunodeficiency Diseases', 'Cardiovascular Diseases-include-Genetic Diseases, Inborn', 'Alzheimer Disease-contribute-Death', 'Osteoarthritis-remain-Cartilage Diseases', 'Hypertension-classified-Dementia', 'Stroke-classified-Dementia', 'Coronary Artery Disease-classified-Dementia', 'Heart Failure-classified-Dementia', 'Pulmonary Disease, Chronic Obstructive-classified-Dementia', 'Dementia-tend-Cardiovascular Diseases', 'Dementia-classified-Cardiovascular Diseases', 'Neurologic Manifestations-promote-Arrhythmias, Cardiac', 'Neurologic Manifestations-promote-Heart Failure', 'Hypertension-hamper-Hypertrophy', 'Hypertension-hamper-Fibrosis', 'Cerebral Small Vessel Diseases-cause-Cerebral Hemorrhage', 'Neurodegenerative Diseases-cover-Rheumatic Diseases', 'Rheumatic Diseases-manifest-Arthritis', 'Rheumatic Diseases-predispose-Joint Diseases', 'Arthritis-require-Joint Diseases', 'Arthritis-predispose-Rheumatic Diseases', 'Rheumatic Diseases-control-Cardiovascular Diseases', 'Rheumatic Diseases-control-Osteoporosis', 'Diabetes Mellitus-suffer-Hyperlipidemias', 'Diabetes Mellitus-suffer-Asthma', 'Neoplasms-prevent-Leukemia, Myeloid, Acute', 'Hypothyroidism-include-Fatigue', 'Hypothyroidism-include-Lethargy', 'Hypothyroidism-include-Skin Diseases', 'HIV Infections-include-Amenorrhea', 'HIV Infections-distinguish-Amenorrhea', 'Heart Neoplasms-reported-Heart Diseases', 'Dementia-predispose-Infections', 'Hemorrhage-reduce-Drug-Related Side Effects and Adverse Reactions', 'Hemorrhage-prevent-Hydrocephalus', 'Alcoholism-associated-Fatigue', 'Fatigue-associated-Alcoholism', 'Diabetes Mellitus, Type 2-associated-Stroke', 'Stroke-associated-Diabetes Mellitus, Type 2', 'Death-remain-Hypertension, Pulmonary', 'Hypothyroidism-associated-Mitochondrial Diseases', 'Mitochondrial Diseases-associated-Hypothyroidism', 'Hypothyroidism-associated-Inflammation', 'Inflammation-associated-Hypothyroidism', 'Hypothyroidism-associated-Fibrosis', 'Fibrosis-associated-Hypothyroidism', 'Heart Diseases-considered-Headache', 'Osteoarthritis-caused-Inflammation', 'Arthritis-caused-Inflammation', 'Stroke-improve-Seizures', 'Diabetes Mellitus-improve-Seizures', 'Heart Failure-cause-Liver Cirrhosis', 'Liver Diseases-improve-Cardiovascular Diseases', 'Liver Failure-assessed-Fibrosis', 'Liver Failure-associated-Fibrosis', 'Fibrosis-associated-Liver Failure', 'Liver Failure-associated-Non-alcoholic Fatty Liver Disease', 'Non-alcoholic Fatty Liver Disease-associated-Liver Failure', 'Liver Failure-associated-Liver Cirrhosis', 'Liver Cirrhosis-associated-Liver Failure', 'Liver Failure-associated-Liver Diseases', 'Liver Diseases-associated-Liver Failure', 'Liver Failure-assessed-Liver Diseases', 'Liver Failure-assessed-Heart Failure', 'Alzheimer Disease-develop-Inflammation', 'Neurodegenerative Diseases-involved-Alzheimer Disease', 'Neurodegenerative Diseases-involved-Parkinson Disease', 'Nerve Degeneration-associated-Sarcopenia', 'Sarcopenia-associated-Nerve Degeneration', 'Nerve Degeneration-associated-Muscular Atrophy', 'Muscular Atrophy-associated-Nerve Degeneration', 'Nerve Degeneration-characterized-Muscular Atrophy', 'Dysbiosis-associated-Aneurysm', 'Aneurysm-associated-Dysbiosis', 'Dysbiosis-involved-Atherosclerosis', 'Neurodegenerative Diseases-termed-Hereditary Breast and Ovarian Cancer Syndrome', 'Neurodegenerative Diseases-termed-Dementia', 'Polymyalgia Rheumatica-hinder-Arthritis, Rheumatoid', 'Adenomatous Polyposis Coli-correlated-Muscle Weakness', 'Skin Neoplasms-induced-Infections', 'Kyphosis-measured-Death', 'Death-progress-Kidney Diseases', 'Sleep Wake Disorders-defined-Disorders of Excessive Somnolence', 'Osteoporosis-encountered-Vascular System Injuries', 'Osteoporosis-lead-Osteogenesis Imperfecta', 'Vascular System Injuries-lead-Osteogenesis Imperfecta', 'Immunologic Deficiency Syndromes-identified-Bone Neoplasms', 'Muscle Weakness-associated-Adenomatous Polyposis Coli', 'Adenomatous Polyposis Coli-associated-Muscle Weakness', 'Death-predict-Inflammation', 'Death-predict-Hyperglycemia', 'Parkinson Disease-act-Osteoporosis', 'Chronic Disease-develop-Osteoporosis', 'Hyponatremia-associate-Psychomotor Disorders', 'Psychomotor Disorders-associate-Hyponatremia', 'Renal Insufficiency-observed-Nephritis', 'Myelodysplastic Syndromes-include-Thrombocytopenia', 'Reperfusion Injury-promote-Neoplasms', 'Fractures, Bone-access-Osteoporosis', 'Dementia-live-Anophthalmos', 'Anophthalmos-live-Dementia', 'Anorexia-undergo-Huntington Disease', 'Huntington Disease-undergo-Anorexia', 'Parkinson Disease, Secondary-reveal-Constipation', 'Parkinson Disease, Secondary-reveal-Inflammation', 'Sarcopenia-control-Obesity', 'Sarcopenia-recommended-Osteoporosis', 'Sarcopenia-control-Osteoporosis', 'Obesity-recommended-Osteoporosis', 'Obesity-control-Osteoporosis', 'Synucleinopathies-associated-Sleep Wake Disorders', 'Sleep Wake Disorders-associated-Synucleinopathies', 'Hypertension-reduce-Heart Diseases', 'Heart Diseases-reduce-Stroke', 'Shock-detect-Blood Coagulation Disorders', 'Movement Disorders-detect-Blood Coagulation Disorders', 'Cardiovascular Diseases-develop-Alzheimer Disease', 'Dementia-confer-Cardiovascular Diseases', 'Malnutrition-decrease-Death', 'Lung Diseases-moderate-Dyspnea', 'Death-observed-Lung Neoplasms', 'Death-observed-Breast Neoplasms', 'Death-observed-Endometrial Neoplasms', 'Hepatitis B-identified-Arbovirus Infections', 'Hepatitis B-identified-Fibrosis', 'Ovarian Neoplasms-known-Endometriosis', 'Hypertrophy, Left Ventricular-characterized-Hypertension', 'Death-increase-Neurodegenerative Diseases', 'Digestive System Neoplasms-attributed-Giardiasis', 'HIV Infections-complicated-Substance-Related Disorders', 'Inflammation-remain-HIV Infections', 'Inflammation-suppress-Viremia', 'HIV Infections-suppress-Viremia', 'Death-counteract-Inflammation', 'Critical Illness-initiate-Thrombosis', 'Malformations of Cortical Development-found-Vision Disorders', 'Neurodegenerative Diseases-explore-Periodontal Diseases', 'Neurodegenerative Diseases-postulate-Infections', 'Aortic Valve Stenosis-impose-Death', 'Leukemia, Myelomonocytic, Chronic-include-Chronic Disease', 'Leukemia, Myelomonocytic, Juvenile-include-Chronic Disease', 'Alzheimer Disease-occur-Inflammation', 'Inflammation-contribute-Thrombosis', 'Heart Arrest-implicated-Cardiovascular Diseases', 'Pneumonia-characterized-Infections', 'Irritable Bowel Syndrome-associated-Endometriosis', 'Endometriosis-associated-Irritable Bowel Syndrome', 'Dementia-use-Fibrosis', 'Dementia-use-Liver Cirrhosis', 'Dementia-diagnose-Fibrosis', 'Dementia-diagnose-Metabolic Syndrome', 'Dementia-diagnose-Brain Injuries, Traumatic', 'Dementia-diagnose-Cerebrovascular Disorders', 'Mitochondrial Diseases-involved-Neoplasms', 'Mitochondrial Diseases-involved-Diabetes Mellitus', 'Mitochondrial Diseases-involved-Obesity', 'Mitochondrial Diseases-involved-Neurodegenerative Diseases', 'Mitochondrial Diseases-involved-Huntington Disease', 'Mitochondrial Diseases-involved-Amyotrophic Lateral Sclerosis', 'Mitochondrial Diseases-involved-Multiple Sclerosis', 'Neoplasm Invasiveness-associated-Death', 'Death-associated-Neoplasm Invasiveness', 'Infections-associated-Neoplasm Invasiveness', 'Neoplasm Invasiveness-associated-Infections', 'Cardiovascular Diseases-caused-Hypertension', 'Neoplasms-include-Sepsis', 'Multiple Organ Failure-label-Sepsis', 'Colorectal Neoplasms-published-Neoplasms', 'Seizures-compare-Cardiovascular Diseases', 'Tinnitus-indicate-Hypercholesterolemia', 'Hearing Disorders-defined-Hearing Loss', 'Hearing Disorders-defined-Tinnitus', 'Hypercholesterolemia-include-Hearing Loss', 'Bacteremia-present-Headache Disorders, Secondary', 'Fever-present-Headache Disorders, Secondary', 'Death-require-Hemorrhage', 'Dementia-exacerbate-Pain', 'Pain-challenge-Dementia', 'Chronic Pain-fit-Seizures', 'Pain-fit-Seizures', 'Hypotension-recorded-Hypercapnia', 'Diabetes Mellitus-concerned-Neoplasms', 'Alzheimer Disease-living-Dementia', 'Neurodegenerative Diseases-develop-Dementia', 'Dementia-damaged-Disease', 'Neurodegenerative Diseases-develop-Parkinson Disease', 'Dementia-dominated-Memory Disorders', 'Dementia-dominated-Genetic Diseases, Inborn', 'Alzheimer Disease-dominated-Memory Disorders', 'Alzheimer Disease-dominated-Genetic Diseases, Inborn', 'Osteoporosis-considered-Neurodegenerative Diseases', 'Low Back Pain-develop-Kyphosis', 'Dyspnea-lead-Pneumonia', 'Fractures, Bone-increase-Pneumonia', 'Tuberculosis, Meningeal-explore-Signs and Symptoms, Respiratory', 'Hemostatic Disorders-play-Cardiovascular Diseases', 'Sotos Syndrome-accumulate-Neurodegenerative Diseases', 'Death-use-Delirium', 'Lung Diseases-receive-Pneumothorax', 'Lung Diseases-receive-Hemorrhage', 'Sleep Initiation and Maintenance Disorders-suffer-Fatigue', 'Sleep Initiation and Maintenance Disorders-suffer-Chronic Disease', 'Retinal Diseases-compared-Anophthalmos', 'Retinal Diseases-base-Anophthalmos', 'Inflammation-influence-Neurodegenerative Diseases', 'Dementia-lead-Headache Disorders, Secondary', 'Dementia-lead-Psychomotor Agitation', 'Dementia-lead-Cardiac Output, Low', 'Vaginal Neoplasms-decline-Atrophic Vaginitis', 'Parkinson Disease, Secondary-become-Dyskinesia, Drug-Induced', 'Vaginal Neoplasms-decline-Vaginosis, Bacterial', 'Parkinson Disease, Secondary-result-Parkinson Disease', 'Infections-identified-Carcinoma', 'Drug-Related Side Effects and Adverse Reactions-identified-Substance-Related Disorders', 'Infections-associated-Hip Fractures', 'Hip Fractures-associated-Infections', 'Trachoma-determine-Trichiasis', 'Fibrosis-upregulated-Aneurysm', 'Shock-contribute-Cataract', 'Shock-contribute-Blindness', 'Ventricular Dysfunction, Left-peak-Ossification of Posterior Longitudinal Ligament', 'Embolism-cause-Death', 'Osteoporosis-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-Osteoporosis', 'Immunologic Deficiency Syndromes-associated-Dyslipidemias', 'Dyslipidemias-associated-Immunologic Deficiency Syndromes', 'Neoplasms-observed-Death', 'Immunologic Deficiency Syndromes-associated-Colorectal Neoplasms', 'Colorectal Neoplasms-associated-Immunologic Deficiency Syndromes', 'Immunologic Deficiency Syndromes-associated-Breast Neoplasms', 'Breast Neoplasms-associated-Immunologic Deficiency Syndromes', 'Immunologic Deficiency Syndromes-associated-Respiratory Tract Infections', 'Respiratory Tract Infections-associated-Immunologic Deficiency Syndromes', 'Skin Neoplasms-resected-Neoplasms', 'Genetic Diseases, Inborn-classified-Cerebellar Ataxia', 'Genetic Diseases, Inborn-classified-Spinocerebellar Ataxias', 'Pain-aimed-Osteoporotic Fractures', 'Cerebrovascular Disorders-predict-Alzheimer Disease', 'Cerebrovascular Disorders-predict-Pulmonary Disease, Chronic Obstructive', 'Hemorrhage-refer-Gingival Hemorrhage', 'Gingivitis-categorized-Gingival Hemorrhage', 'Parkinson Disease-associated-Primary Dysautonomias', 'Primary Dysautonomias-associated-Parkinson Disease', 'Diabetes Mellitus-control-Weight Loss', 'Atherosclerosis-documented-Cerebrovascular Disorders', 'Mitochondrial Diseases-lead-Acute Kidney Injury', 'Kidney Diseases-used-Acute Kidney Injury', 'Kidney Diseases-define-Acute Kidney Injury', 'Diabetes Mellitus-compromise-Cerebrovascular Disorders', 'Infections-increase-Fibrosis', 'Infections-increase-Carcinoma, Hepatocellular', 'Death-related-Liver Diseases', 'Hyperkinesis-reported-Alzheimer Disease', 'Polymyalgia Rheumatica-present-Stiff-Person Syndrome', 'Fractures, Bone-suffer-Hip Fractures', 'Inflammation-associated-Venous Thromboembolism', 'Venous Thromboembolism-associated-Inflammation', 'Liver Cirrhosis-regulate-Inflammation', 'Chronic Disease-become-Death', 'Infections-accompany-Discitis', 'Pancreatitis-increase-Death', 'Cardiovascular Diseases-observed-Ventricular Remodeling', 'Neoplasms-compare-Breast Neoplasms', 'Breast Neoplasms-increase-Death', 'Death-projected-Prostatic Neoplasms', 'Cerebral Infarction-live-Osteoarthritis', 'Kidney Diseases-live-Osteoarthritis', 'Arthritis, Rheumatoid-live-Osteoarthritis', 'Sarcopenia-associated-Aneurysm', 'Aneurysm-associated-Sarcopenia', 'Airway Obstruction-promote-Fibrosis', 'Fibrosis-persist-Kidney Diseases', 'Constipation-occur-Pain Insensitivity, Congenital', 'Sleep Wake Disorders-associated-Heredodegenerative Disorders, Nervous System', 'Heredodegenerative Disorders, Nervous System-associated-Sleep Wake Disorders', 'Infections-known-Candidiasis, Vulvovaginal', 'Critical Illness-associated-Dementia', 'Dementia-associated-Critical Illness', 'Colorectal Neoplasms-isolated-Neoplasms', 'Inflammation-resist-Death', 'Disease-share-Heart Failure, Diastolic', 'Heart Failure, Diastolic-share-Heart Failure', 'Osteoporotic Fractures-consist-Weight Loss', 'Diabetes Mellitus-alter-Dementia', 'Musculoskeletal Diseases-fall-Cardiac Output, Low', 'Osteoporosis-predict-Diabetes Mellitus, Type 2', 'Neoplasms-treated-Infections', 'Death-live-Malnutrition', 'Delirium-live-Malnutrition', 'Delirium-live-Pain', 'Malnutrition-live-Pain', 'Proteostasis Deficiencies-accelerated-Neurodegenerative Diseases', 'Cardiac Output, Low-defined-Contusions', 'Cardiac Output, Low-cause-Contusions', 'Cell Transformation, Viral-trigger-Myelodysplastic Syndromes', 'Cardiac Output, Low-defined-Unconsciousness', 'Cardiac Output, Low-cause-Unconsciousness', 'Cardiac Output, Low-defined-Pain', 'Cardiac Output, Low-report-Pain', 'Contusions-report-Pain', 'Unconsciousness-report-Pain', 'Obesity-cause-Inflammation', 'Obesity-lead-Heart Failure', 'Inflammation-lead-Heart Failure', 'Obesity-related-Heart Failure', 'Obesity-display-Heart Failure', 'Heart Failure-increasing-Diabetes Mellitus', 'Heart Failure-increasing-Hypertension', 'Lymphopenia-associated-Pregnancy Complications, Infectious', 'Pregnancy Complications, Infectious-associated-Lymphopenia', 'Death-control-Asthma', 'Venous Thrombosis-affect-Pulmonary Embolism', 'Venous Thrombosis-carry-Death', 'Aneurysm-develop-Thrombosis', 'Malnutrition-involve-Neoplasms', 'Malnutrition-involve-Diabetes Mellitus', 'Malnutrition-involve-Heart Diseases', 'Infections-include-Joint Dislocations', 'Stroke-driven-Heart Septal Defects, Ventricular', 'Inflammation-promote-Neurodegenerative Diseases', 'Myocardial Infarction-driven-Heart Septal Defects, Ventricular', 'Heart Failure-driven-Heart Septal Defects, Ventricular', 'Diabetes Mellitus-followed-Lung Diseases', 'Neoplasms-examine-Thyroid Neoplasms', 'Neoplasms-show-Adenomatous Polyposis Coli', 'Hypotension, Orthostatic-associated-Aortic Diseases', 'Aortic Diseases-associated-Hypotension, Orthostatic', 'Hypotension, Orthostatic-associated-Orthostatic Intolerance', 'Orthostatic Intolerance-associated-Hypotension, Orthostatic', 'Hypotension, Orthostatic-associated-Heart Failure, Systolic', 'Heart Failure, Systolic-associated-Hypotension, Orthostatic', 'Orthostatic Intolerance-associated-Heart Failure, Systolic', 'Heart Failure, Systolic-associated-Orthostatic Intolerance', 'Infections-alleviate-Inflammation', 'Infections-treat-Heart Diseases', 'Infections-optimize-Death', 'Myotonic Dystrophy-associated-Arteriolosclerosis', 'Arteriolosclerosis-associated-Myotonic Dystrophy', 'Parkinson Disease-test-Death', 'Substance-Related Disorders-predict-Dystonia', 'Obesity-match-Chronic Disease', 'Proteostasis Deficiencies-describe-Cataract', 'Proteostasis Deficiencies-describe-Glaucoma', 'Anophthalmos-describe-Cataract', 'Anophthalmos-discuss-Glaucoma', 'Hypogonadism-related-Hypotension', 'Hypogonadism-remit-Hypotension', 'Hypogonadism-reverse-Hypotension', 'Drug-Related Side Effects and Adverse Reactions-ensure-Adenomatous Polyposis Coli', 'Hyperthyroidism-result-Thyroid Diseases', 'Hypothyroidism-result-Thyroid Diseases', 'Thyroid Hormone Resistance Syndrome-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-Thyroid Hormone Resistance Syndrome', 'Inflammation-known-Mitochondrial Diseases', 'Osteoporosis-seen-Cardiovascular Diseases', 'Osteoporosis-seen-Hypertension', 'Osteoporosis-seen-Diabetes Mellitus', 'Osteoporotic Fractures-linked-Cardiovascular Diseases', 'Cardiovascular Diseases-predispose-Osteoporosis', 'Osteoporosis-underlie-Cardiovascular Diseases', 'Osteoporosis-characterized-Inflammation', 'Atherosclerosis-underlie-Cardiovascular Diseases', 'Myelodysplastic Syndromes-inspired-Leukemia, Myeloid, Acute', 'Carcinoma, Hepatocellular-induce-Hyperlipidemias', 'Precursor Cell Lymphoblastic Leukemia-Lymphoma-treat-Inflammatory Bowel Diseases', 'Unconsciousness-fall-Amnesia', 'Unconsciousness-require-Epilepsy', 'Amnesia-require-Epilepsy', 'Bone Diseases, Metabolic-defined-Sarcopenia', 'Muscular Dystrophy, Duchenne-defined-Sarcopenia', 'Coronary Artery Disease-exhibit-Diabetes Mellitus', 'Frontotemporal Lobar Degeneration-confirm-Retinal Degeneration', 'Sarcopenia-categorized-Neoplasms', 'Cachexia-assess-Neoplasms', 'Intervertebral Disc Degeneration-occur-Myopathies, Structural, Congenital', 'Intervertebral Disc Degeneration-thought-Back Pain', 'Musculoskeletal Diseases-amputate-Kidney Diseases', 'Dental Caries-treat-Candidiasis', 'Dental Caries-manage-Xerostomia', 'Candidiasis-manage-Xerostomia', 'Diabetes Mellitus-related-Neoplasms', 'Neoplasms-tailored-Diabetes Mellitus, Type 2', 'Inflammation-treat-Neoplasms', 'Thoracic Outlet Syndrome-push-Cerebral Infarction', 'Aneurysm-stratified-Neoplasms', 'Mitochondrial Diseases-perturb-Dysgeusia', 'Dysgeusia-perturb-Alzheimer Disease', 'Demyelinating Diseases-observed-Neurodegenerative Diseases', 'Lipomatosis-cause-Corneal Dystrophies, Hereditary', 'Pain-report-Mucopolysaccharidosis III', 'Thrombocytopenia-increase-Death', 'Oculocerebrorenal Syndrome-followed-Immunologic Deficiency Syndromes', 'Neurodegenerative Diseases-link-Olfaction Disorders', 'Epilepsy, Absence-reduce-Musculoskeletal Diseases', 'Chronic Disease-used-Hearing Loss', 'Hemorrhage-require-Infections', 'Fractures, Bone-prevent-Death', 'Death-show-Infections', 'Neurodegenerative Diseases-associated-Infarction', 'Infarction-associated-Neurodegenerative Diseases', 'Fractures, Bone-remain-Kyphosis', 'Nail-Patella Syndrome-recorded-Dementia', 'Gastrointestinal Diseases-include-Metabolic Diseases', 'Neoplasms-include-Metabolic Diseases', 'Bone Neoplasms-reported-Fractures, Bone', 'Memory Disorders-include-Chronic Disease', 'Kidney Diseases-include-Chronic Disease', 'Acute Coronary Syndrome-based-Hemophilia A', 'Death-elevated-Dementia', 'Diabetes Mellitus-exhibit-Coinfection', 'Atrophy-show-Glucose Metabolism Disorders', 'Alzheimer Disease-underpinned-Neurodegenerative Diseases', 'Liver Cirrhosis-receive-Hyperlipidemias', 'Thyroid Diseases-receive-Hyperlipidemias', 'Drug-Related Side Effects and Adverse Reactions-treat-Mastocytosis, Cutaneous', 'Wounds and Injuries-improve-Retinal Perforations', 'Metabolic Diseases-associated-Infections', 'Infections-associated-Metabolic Diseases', 'Death-predict-Pulmonary Disease, Chronic Obstructive', 'Obesity-coexist-Immunologic Deficiency Syndromes', 'Inflammation-include-Delirium', 'Werner Syndrome-manifest-Diabetes Mellitus', 'Werner Syndrome-manifest-Hyperlipidemias', 'Werner Syndrome-manifest-Hypertension', 'Werner Syndrome-create-Neoplasms', 'Werner Syndrome-manifest-Skin Diseases', 'Werner Syndrome-manifest-Cataract', 'Werner Syndrome-manifest-Myocardial Infarction', 'Werner Syndrome-manifest-Osteoporosis', 'Werner Syndrome-manifest-Stroke', 'Aging, Premature-manifest-Diabetes Mellitus', 'Aging, Premature-manifest-Hyperlipidemias', 'Aging, Premature-manifest-Hypertension', 'Aging, Premature-manifest-Skin Diseases', 'Aging, Premature-manifest-Cataract', 'Aging, Premature-manifest-Myocardial Infarction', 'Aging, Premature-manifest-Osteoporosis', 'Aging, Premature-manifest-Stroke', 'Fibrosis-followed-Myotonic Dystrophy', 'Fibrosis-followed-Obesity', 'Fibrosis-associated-Hyperlipidemias', 'Hyperlipidemias-associated-Fibrosis', 'Liver Cirrhosis-predict-Hepatitis C, Chronic', 'Myotonic Dystrophy-predict-Hepatitis C, Chronic', 'Myotonic Dystrophy-increase-Hepatitis C, Chronic', 'Obesity-include-Dyspnea', 'Heart Failure-provide-Renal Insufficiency, Chronic', 'Brain Injuries, Traumatic-accelerate-Atrophy', 'Fibrosis-fall-Cardiac Output, Low', 'Hydrocephalus-described-Gait Apraxia', 'Hydrocephalus-develop-Gait Apraxia', 'Hydrocephalus-described-Urinary Incontinence', 'Hydrocephalus-cause-Urinary Incontinence', 'Neoplasms-play-Reperfusion Injury', 'Neoplasms-play-Inflammation', 'Stroke-identify-Muscle Spasticity', 'Giant Cell Arteritis-include-Vasculitis', 'Cleidocranial Dysplasia-share-Alzheimer Disease', 'Obesity-increase-Communicable Diseases', 'Hypertension-represent-Dementia', 'Sarcopenia-caused-Dehydration', 'Stroke-play-Infections', 'Stroke-emerge-Fever', 'Stroke-emerge-Influenza, Human', 'Inflammation-implicated-Metabolic Diseases', 'Dental Pulp Necrosis-detected-Fractures, Bone', 'Fatigue-defined-Sleep Initiation and Maintenance Disorders', 'Inflammation-cause-Fatigue', 'Mitochondrial Diseases-cause-Fatigue', 'Fatigue-include-Nervous System Malformations', 'Fatigue-proposed-Nervous System Malformations', 'Death-carry-Breast Neoplasms', 'Neuroaxonal Dystrophies-change-Heredodegenerative Disorders, Nervous System', 'Atherosclerosis-belong-Aneurysm', 'Atherosclerosis-lead-Rupture', 'Atherosclerosis-belong-Thromboembolism', 'Atherosclerosis-belong-Cardiovascular Diseases', 'Aneurysm-lead-Rupture', 'Aneurysm-lead-Thromboembolism', 'Aneurysm-lead-Cardiovascular Diseases', 'Rupture-lead-Thromboembolism', 'Rupture-lead-Cardiovascular Diseases', 'Hyperpigmentation-reduce-Pigmentation Disorders', 'Hypertension-combined-Osteoporosis', 'Hypertension-fall-Fractures, Bone', 'Mitochondrial Diseases-induced-Alzheimer Disease', 'Inflammation-induced-Alzheimer Disease', 'Critical Illness-show-Hamartoma Syndrome, Multiple', 'Inflammation-target-Cardiovascular Diseases', 'Ovarian Neoplasms-increase-Death', 'Chronic Disease-mediated-Inflammation', 'Glycogen Storage Disease Type II-targeted-Neurodegenerative Diseases', 'Death-experience-Fragile X Syndrome', 'Osteoporosis-based-Hypotension', 'Death-compare-Aortic Aneurysm, Thoracic', 'HIV Infections-included-Sarcopenia', 'HIV Infections-considered-Sarcopenia', 'Sarcopenia-live-Immunologic Deficiency Syndromes', 'Cardiotoxicity-develop-Cardiovascular Diseases', 'Cardiotoxicity-develop-Ventricular Dysfunction', 'Cardiotoxicity-develop-Heart Failure', 'Cardiotoxicity-develop-Arrhythmias, Cardiac', 'Cardiotoxicity-develop-Hypertension', 'Cardiotoxicity-develop-Coronary Artery Disease', 'Alzheimer Disease-influence-Neurogenic Inflammation', 'Alzheimer Disease-identified-Gliosis', 'Hypothalamic Diseases-focus-Inflammation', 'Infections-linked-Communicable Diseases', 'Infections-linked-Tuberculosis', 'Infections-linked-HIV Infections', 'Movement Disorders-include-Myoclonus', 'Hypoxia-linked-Neurodegenerative Diseases', 'Alzheimer Disease-highlight-Neurologic Manifestations', 'Osteoporosis-correspond-Sexual Dysfunction, Physiological', 'Ichthyosis, X-Linked-associated-Bone Neoplasms', 'Bone Neoplasms-associated-Ichthyosis, X-Linked', 'Ichthyosis, X-Linked-associated-Fractures, Bone', 'Fractures, Bone-associated-Ichthyosis, X-Linked', 'Osteoporotic Fractures-lack-Fractures, Bone', 'Obesity-associate-Hypogonadism', 'Hypogonadism-associate-Obesity', 'Hypogonadism-associate-Diabetes Mellitus', 'Diabetes Mellitus-associate-Hypogonadism', 'Neoplasms-identify-Paralysis', 'Adenomatous Polyposis Coli-assessed-Sarcopenia', 'Sarcopenia-investigate-Adenomatous Polyposis Coli', 'Sarcopenia-assess-Renal Insufficiency, Chronic', 'Sarcopenia-assess-Kidney Failure, Chronic', 'Glomerulonephritis-related-Infections', 'Diabetes Mellitus-complicated-Lymphohistiocytosis, Hemophagocytic', 'Diabetes Mellitus-complicated-Cytomegalovirus Infections', 'Streptococcal Infections-complicated-Lymphohistiocytosis, Hemophagocytic', 'Streptococcal Infections-complicated-Cytomegalovirus Infections', 'Precancerous Conditions-diagnosed-Neoplasms', 'Fatty Liver-assessed-Liver Failure', 'Death-adjusted-Metabolic Syndrome', 'Death-adjusted-Heart Failure', 'Death-adjusted-Coronary Artery Disease', 'Chronic Kidney Disease-Mineral and Bone Disorder-followed-Myotonic Dystrophy', 'Death-followed-Myotonic Dystrophy', 'Infections-followed-Myotonic Dystrophy', 'Cardiovascular Diseases-lessen-Fractures, Bone', 'Stomach Neoplasms-undergo-Hemorrhage', 'Obesity-defined-Communicable Diseases', 'Cardiovascular Diseases-used-Obesity', 'Cardiovascular Diseases-screen-Obesity', 'Obesity-defined-Cardiovascular Diseases', 'Parkinson Disease-produce-Nerve Degeneration', 'Neoplasms-identified-Inflammatory Bowel Diseases', 'Death-occur-Inflammatory Bowel Diseases', 'Parkinson Disease-coincide-Parkinsonian Disorders', 'Cholecystitis-followed-Cholangitis', 'Cardiovascular Diseases-compare-Obesity', 'Polyploidy-prevent-Liver Cirrhosis', 'Hypertension-take-Cardiac Output, Low', 'Atrophic Vaginitis-help-Alzheimer Disease', 'Kidney Diseases-include-Diabetic Nephropathies', 'Diabetic Nephropathies-include-Fibrosis', 'Diabetic Nephropathies-include-Adenocarcinoma', 'Alstrom Syndrome-show-Fibrosis', 'Alstrom Syndrome-show-Diabetes Mellitus', 'Polyps-develop-Colorectal Neoplasms', 'Alzheimer Disease-emerge-Dementia', 'Neurodegenerative Diseases-emerge-Dementia', 'Inflammation-underlie-Peripheral Vascular Diseases', 'Coronary Artery Disease-play-Cardiotoxicity', 'Diabetes Mellitus-contribute-Intervertebral Disc Degeneration', 'Sarcopenia-receive-Huntington Disease', 'Dementia-known-Neurodegenerative Diseases', 'Peritoneal Neoplasms-regarded-Headache Disorders, Secondary', 'Hypertension-correlated-Headache Disorders, Secondary', 'Atrial Fibrillation-validated-Muscular Diseases', 'Arrhythmias, Cardiac-find-Atrial Fibrillation', 'Nocturia-correlate-Prostatic Hyperplasia', 'Nocturia-correlate-Urinary Bladder Neck Obstruction', 'Nocturia-correlate-Prostatitis', 'Bruxism-followed-Periodontal Diseases', 'Bruxism-followed-Ulcer', 'Metabolic Syndrome-define-Diabetes Mellitus, Type 2', 'Metabolic Syndrome-associated-Nephrolithiasis', 'Nephrolithiasis-associated-Metabolic Syndrome', 'Metabolic Syndrome-define-Glucose Metabolism Disorders', 'Spinal Dysraphism-score-Spinal Cord Injuries', 'Fatigue-include-Spinal Dysraphism', 'Spinal Dysraphism-include-Pain', 'Retinal Degeneration-involve-Death', 'HIV Infections-experience-Musculoskeletal Diseases', 'HIV Infections-experience-Nervous System Diseases', 'Metabolic Diseases-associate-Hypothalamic Neoplasms', 'Hypothalamic Neoplasms-associate-Metabolic Diseases', 'Hypogonadism-defined-Diabetes Mellitus', 'Hypogonadism-defined-Obesity', 'Hypogonadism-defined-Metabolic Syndrome', 'Hypothermia-associated-Postoperative Complications', 'Postoperative Complications-associated-Hypothermia', 'Hemophilia A-reduce-Pain', 'Pain-minimise-Cardiac Output, Low', 'Periodontal Diseases-described-Pain', 'Periodontal Diseases-affect-Pain', 'Pancreatic Neoplasms-include-Adenocarcinoma', 'Pancreatic Neoplasms-include-Adenocarcinoma, Mucinous', 'Fatigue-play-Wounds and Injuries', 'Sleep Wake Disorders-increase-Restless Legs Syndrome', 'Psoriasis-termed-Arthritis, Psoriatic', 'Polycystic Ovary Syndrome-increase-Prediabetic State', 'Sleep Wake Disorders-determine-Polycystic Ovary Syndrome', 'Polycystic Ovary Syndrome-increase-Communicable Diseases', 'Seizures-follow-Cerebral Infarction', 'Seizures-present-Cerebral Infarction', 'Magnesium Deficiency-associated-Memory Disorders', 'Memory Disorders-associated-Magnesium Deficiency', 'Venous Thrombosis-followed-Dysuria', 'Venous Thromboembolism-associated-Paralysis', 'Paralysis-associated-Venous Thromboembolism', 'Venous Thromboembolism-associated-Venous Thrombosis', 'Venous Thrombosis-associated-Venous Thromboembolism', 'Venous Thromboembolism-rehabilitate-Spinal Cord Injuries', 'Venous Thromboembolism-associated-Paraplegia', 'Paraplegia-associated-Venous Thromboembolism', 'Venous Thromboembolism-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-Venous Thromboembolism', 'Spinal Cord Injuries-associated-Paralysis', 'Paralysis-associated-Spinal Cord Injuries', 'Spinal Cord Injuries-associated-Venous Thrombosis', 'Venous Thrombosis-associated-Spinal Cord Injuries', 'Spinal Cord Injuries-associated-Paraplegia', 'Paraplegia-associated-Spinal Cord Injuries', 'Spinal Cord Injuries-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-Spinal Cord Injuries', 'Lupus Erythematosus, Systemic-report-Headache Disorders, Secondary', 'Adrenal Insufficiency-coexist-Laryngeal Diseases', 'Diastasis, Bone-diagnosed-Pelvic Floor Disorders', 'Sarcopenia-diminish-Neoplasms', 'Sarcopenia-diminish-Cachexia', 'Heart Failure-attribute-Alzheimer Disease', 'Alzheimer Disease-moderate-Heart Failure', 'Nadroparin-used-FOS', 'Nadroparin-target-FOS', 'Glucose-reduce-Inflammation', 'ALOX5-found-Atrophy', 'Leukotriene B4-found-Atrophy', 'Joint Dislocations-correlate-APOE', 'CAT-increase-Glutathione', 'Cholesterol-associated-COG2', 'COG2-associated-Cholesterol', 'COG2-associated-Atherosclerosis', 'Atherosclerosis-associated-COG2', 'TERF1-associated-Glycogen Storage Disease Type II', 'Glycogen Storage Disease Type II-associated-TERF1', 'rs10107605-associated-Glycogen Storage Disease Type II', 'Glycogen Storage Disease Type II-associated-rs10107605', 'SATB2-bind-rs1537371', 'Endometriosis-identify-DGKB', 'Endometriosis-identify-rs12666606', 'ALB-indicate-Osteoporosis', 'ALB-remain-Osteoporosis', 'MYO1B-ameliorate-Neurologic Manifestations', 'MAPT-make-Alzheimer Disease', 'Psoriasis-choose-IFNG', 'Glycogen Storage Disease Type II-elevated-TERF1', 'Alzheimer Disease-decrease-MAPT', 'NRGN-investigated-Alzheimer Disease', 'Neurodegenerative Diseases-divided-MAPT', 'Hypoglycemia-prevent-INS', 'DDIT3-identify-Myelodysplastic Syndromes', 'DDIT3-characterize-Myelodysplastic Syndromes', 'EP300-participate-Fibrosis', 'DAPK1-involve-Alzheimer Disease', 'MMP9-show-Glycogen Storage Disease Type II', 'MMP9-linked-Retinal Diseases', 'MMP9-linked-Glycogen Storage Disease Type II', 'CRP-associated-Pneumococcal Infections', 'Pneumococcal Infections-associated-CRP', 'Arthritis, Rheumatoid-assess-CRP', 'COG2-result-Atherosclerosis', 'ACO2-implied-Mitochondrial Diseases', 'Parkinson Disease-associated-COMT', 'COMT-associated-Parkinson Disease', 'ERBB2-evaluate-Stomach Neoplasms', 'ERBB2-base-Neoplasms', 'Alzheimer Disease-provide-INS', 'CLU-explore-Alzheimer Disease', 'CYP3A4-minimize-Hypotension, Orthostatic', 'CRP-determine-Infections', 'Glucosephosphate Dehydrogenase Deficiency-decrease-CRP', 'LONP1-accelerate-Neoplasms', 'FGF21-occur-Obesity', 'Alzheimer Disease-compare-MAPT', 'Heart Arrest-inhibit-KL', 'DKK1-contribute-Alzheimer Disease', 'RBP4-compare-Sarcopenia', 'RBP4-correlated-Sarcopenia', 'RBP4-predict-Sarcopenia', 'PCSK1-compared-Nervous System Diseases', 'PCSK1-associated-Nervous System Diseases', 'Nervous System Diseases-associated-PCSK1', 'CLOCK-affect-Stroke', 'Infections-normalized-CRP', 'DYRK1A-serve-Neurodegenerative Diseases', 'Wounds and Injuries-reversed-TFRC', 'ACKR1-progress-Neoplasms', 'CHAT-find-Alzheimer Disease', 'TP53-live-Cold Injury', 'TLR4-result-Neurodegenerative Diseases', 'GDF15-correlated-Neurodegenerative Diseases', 'TLR4-connected-Diabetes Mellitus', 'TLR4-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-TLR4', 'Cystic Fibrosis-suffer-CFTR', 'Neoplasms-stimulate-VEGFA', 'Neoplasms-associated-NEIL1', 'NEIL1-associated-Neoplasms', 'Alzheimer Disease-modulate-BACE1', 'TMEM106B-reflect-Lysosomal Storage Diseases', 'F3-predict-Death', 'F3-associated-Death', 'Death-associated-F3', 'F3-increased-Death', 'NLRP3-increase-Inflammation', 'NLRP3-dysregulated-Leukemia, Myelomonocytic, Juvenile', 'NOTCH1-prevent-Carcinoma, Squamous Cell', 'NOTCH1-reduce-Neoplasms', 'NOTCH1-favor-Neoplasms', 'EZH2-treat-Neoplasms', 'Parkinsonian Disorders-mitigated-GDNF', 'MAPK14-reduce-Inflammation', 'Parkinsonian Disorders-augment-TH', 'Wounds and Injuries-reduce-SOX9', 'METTL3-down-regulated-Kidney Diseases', 'CDKN2A-increase-Breast Neoplasms', 'SIRT6-protect-Blister', 'CYP19A1-associated-Breast Neoplasms', 'Breast Neoplasms-associated-CYP19A1', 'SIRT6-affect-Liver Failure', 'SIRT6-play-Liver Diseases', 'Melanoma-downregulate-LGI4', 'LGI4-show-Polyradiculoneuropathy, Chronic Inflammatory Demyelinating', 'KL-study-Lupus Erythematosus, Systemic', 'GDF15-induce-Mitochondrial Diseases', 'UMOD-associate-Hypertension', 'Hypertension-associate-UMOD', 'TIMP1-result-Fibrosis', 'TIMP1-lead-Fibrosis', 'KL-differ-Lupus Erythematosus, Systemic', 'TIMP2-play-Inflammation', 'CDKN2A-associated-Atherosclerosis', 'Atherosclerosis-associated-CDKN2A', 'Skin Diseases-related-ELN', 'Chronic Disease-stratified-INS', 'RUBCN-regulate-Death', 'ISLR2-show-Sarcopenia', 'DANCR-involved-Neoplasms', 'Anthracyclines-associated-Death', 'Death-associated-Anthracyclines', 'Weight Gain-lower-Glucose', 'Glucose-demonstrate-Weight Gain', 'Drug-Related Side Effects and Adverse Reactions-investigated-Etoposide', 'Arrhythmias, Cardiac-assess-Glucose', 'Glucose-evaluate-Ataxia', 'Glucose-used-Glycosuria', 'Glucose-promote-Glycosuria', 'Anthocyanins-reduce-Dementia', 'Glucose-range-Neurodegenerative Diseases', 'Lymphoma-diagnosed-Doxorubicin', 'Glucose-follow-Diabetes Mellitus', 'Butyrates-alleviate-Neurodegenerative Diseases', 'Hypoglycemia-include-Glucose', 'Cardiolipins-hinder-Alzheimer Disease', 'Thioctic Acid-stabilize-Alzheimer Disease', 'Calcitriol-reduce-Death', 'Seizures-treated-Valproic Acid', 'Tramadol-fall-Pain', 'Hyperpigmentation-face-Lipofuscin', 'Cholecalciferol-increase-Muscular Dystrophy, Duchenne', 'Thyrotropin-assessed-Death', 'rs11189312-related-Sarcopenia', 'Neoplasms-correlated-PGR', 'Neoplasms-correlated-ESR1', 'LDHA-associated-Glucose', 'Glucose-associated-LDHA', 'LDHA-correlated-Glucose', 'CCT6A-associated-Glucose', 'Glucose-associated-CCT6A', 'CCT6A-correlated-Glucose', 'FLT1-associated-Alzheimer Disease', 'Alzheimer Disease-associated-FLT1', 'VEGFB-associated-Alzheimer Disease', 'Alzheimer Disease-associated-VEGFB', 'PGF-associated-Alzheimer Disease', 'Alzheimer Disease-associated-PGF', 'FLT4-associated-Alzheimer Disease', 'Alzheimer Disease-associated-FLT4', 'NEFL-altered-Alzheimer Disease', 'GFAP-altered-Alzheimer Disease', 'FCRL3-include-FCRLA', 'FCRL3-suggest-Autoimmune Diseases', 'FCRLA-suggest-Autoimmune Diseases', 'Hyperemia-accelerate-Lymphopenia', 'GFAP-measured-Huntington Disease', 'NEFL-measured-Huntington Disease', 'TRIB2-increase-Hyperemia', 'Contracture-reveal-COL1A2', 'TRIB2-accelerate proliferation during-Lymphopenia', 'NPC1-involved-Cholesterol', 'NPC1-involved-Sphingolipids', 'Inflammation-contribute-TNF', 'NLRP3-recruit-GSDMD', 'NLRP3-recruit-Inflammation', 'NLRP3-recruit-Death', 'NR1D1-be higher in-Death', 'CLU-properties with-APOE', 'CLU-known-APOE', 'ARNTL-be higher in-Death', 'BTN3A1-associated-Melanoma', 'Melanoma-associated-BTN3A1', 'CYTIP-associated-Melanoma', 'Melanoma-associated-CYTIP', 'CLU-share-Alzheimer Disease', 'RASGRP1-serve after-Melanoma', 'ENO2-compare-NEFL', 'HIF1AN-associated-Melanoma', 'Melanoma-associated-HIF1AN', 'BDNF-compare-NEFL', 'CTSD-associated-Melanoma', 'Melanoma-associated-CTSD', 'ENO2-follow-Renal Insufficiency', 'Scrub Typhus-measure-TNF', 'Glucose-factors for-Cataract', 'NEFL-follow-Renal Insufficiency', 'Eicosanoids-associated-Inflammation', 'Inflammation-associated-Eicosanoids', 'FABP4-promote-Cholesterol', 'Drug-Related Side Effects and Adverse Reactions-considered-Parkinson Disease', 'FABP4-promote-Fatty Acids', 'Butyrates-protect-Drug-Related Side Effects and Adverse Reactions', 'FABP4-reverse-Metabolic Diseases', 'Metabolic Diseases-promote-Cholesterol', 'TGFBR2-found-rs56105708', 'Metabolic Diseases-promote-Fatty Acids', 'Butyrates-show-Parkinson Disease', 'Fatty Acids-protect-Drug-Related Side Effects and Adverse Reactions', 'TGFBR2-found-rs34833812', 'Fatty Acids-show-Parkinson Disease', 'Trichothecenes-seem-Hypoxia', 'Hypoxia-seem-Aflatoxins', 'Mastocytosis, Systemic-derived-Hypoxia', 'Demyelinating Diseases-caused-ABCD1', 'Mastocytosis, Systemic-produce-Hyperglycemia', 'Cardiovascular Diseases-attributed-Obesity', 'Cardiovascular Diseases-attributed-Glucose', 'Mastocytosis, Systemic-derived-Retinal Diseases', 'Mastocytosis, Systemic-derived-Diabetes Mellitus', 'Hypoxia-produce-Hyperglycemia', 'DYRK1A-assess-Alzheimer Disease', 'Hypoxia-mimic-Retinal Diseases', 'DYRK1A-assess-Tauopathies', 'Hypoxia-mimic-Diabetes Mellitus', 'Hyperglycemia-mimic-Retinal Diseases', 'Hyperglycemia-mimic-Diabetes Mellitus', 'Mastocytosis, Systemic-derived-Glucose', 'Glucose-produce-Hyperglycemia', 'Alzheimer Disease-cause-Periodontitis', 'Coronaviridae Infections-cause-Heart Failure', 'Coronaviridae Infections-thrive-Muscle Weakness', 'Brain Diseases, Metabolic-represent-Alzheimer Disease', 'Heart Failure-thrive-Muscle Weakness', 'Coronaviridae Infections-be in-PCYT2', 'PCYT2-cause-Heart Failure', 'Brain Diseases, Metabolic-associated-Diabetes Mellitus, Type 2', 'Diabetes Mellitus, Type 2-associated-Brain Diseases, Metabolic', 'PCYT2-thrive-Muscle Weakness', 'Brain Diseases, Metabolic-known-Diabetes Mellitus', 'Alzheimer Disease-represent-Diabetes Mellitus, Type 2', 'rs2549794-implicated-ERAP2', 'Death-implicated-ERAP2', 'Alzheimer Disease-represent-Diabetes Mellitus', 'ERAP2-implicated-Autoimmune Diseases', 'Stroke-extend-Neurodegenerative Diseases', 'INS-represent-Alzheimer Disease', 'NEFL-admitted-Stroke', 'ERAP2-associated-Respiratory Tract Infections', 'Respiratory Tract Infections-associated-ERAP2', 'NEFL-extend-Neurodegenerative Diseases', 'INS-known-Diabetes Mellitus', 'ERAP2-associated-Autoimmune Diseases', 'Autoimmune Diseases-associated-ERAP2', 'NEFL-investigate-Stroke', 'NEFL-investigate-Brain Infarction', 'Hypertension, Pulmonary-compare-Alveolitis, Extrinsic Allergic', 'Hypertension, Pulmonary-compare-Pulmonary Disease, Chronic Obstructive', 'IGFBP2-suppressed-Hypertension, Pulmonary', 'IGFBP2-suppressed-Alveolitis, Extrinsic Allergic', 'IGFBP2-suppressed-Pulmonary Disease, Chronic Obstructive', 'Weight Loss-demonstrate-Lung Injury', 'Weight Loss-demonstrate-Bleomycin', 'Inflammation-become-Death', 'NLRP3-implicated-Inflammation', 'NLRP3-implicated-Death', 'NLRP3-become-Death', 'HIV Infections-be those with-CD4', 'Neurotoxicity Syndromes-cause-Metabolic Diseases', 'Doxorubicin-cause-Metabolic Diseases', 'APOD-expressed-Alzheimer Disease', 'APOD-expressed-Atherosclerosis', 'Doxorubicin-be cornerstone of-Neoplasms', 'Non-alcoholic Fatty Liver Disease-reduce-Liver Cirrhosis', 'Obesity-induce-Heart Arrest', 'Non-alcoholic Fatty Liver Disease-present-Triglycerides', 'TXNIP-induce-Obesity', 'Death-double-CRP', 'CRP-double-Sepsis', 'CRP-double-Infections', 'CRP-double-Myocardial Infarction', 'SP4-synthesise-SP3', 'SP4-synthesise-SP2', 'SDHC-be membrane anchored subunit of-SDHB', 'CD4-correlate with-AMH', 'TAT-result-CDKN2A', 'TAT-result-TUG1', 'MYC-common EV-TNPO1', 'MYC-miRNAs-TNPO1', 'ENO2-measured-NEFL', 'BDNF-measured-NEFL', 'BDNF-baseline-NEFL', 'TRIB2-be abundant in-CD4', 'TRIB2-counteract quiescence exit by-AKT1', 'TRIB2-suppress-AKT1', 'TRIB2-be abundant than-CD8A', 'STK17A-identify-S100A4', 'PLEK-attributed-TP53', 'EIF2AK3-be in-TP53', 'PLEK-attributed-EIF2AK3', 'EIF2AK3-required-PLEK', 'TP53-control-PLEK', 'ALB-correlate-GDF11', 'ALB-tend-GDF11', 'EZH2-investigate-COL1A2', 'EZH2-increase-COL1A2', 'SIRT1-related-IL6', 'SIRT1-related-CXCL8', 'EZH2-increase-NFKB1', 'EZH2-form-DNMT1', 'EZH2-enhance-COL1A2', 'DNMT1-enhance-COL1A2', 'EZH2-reduce-COL1A2', 'EZH2-improve-COL1A2', 'FBXO7-identify-SIRT7', 'FBXO7-promote-RPS20', 'FBXO7-blockade of-SIRT7', 'FBXO7-promote-SIRT7', 'FBXO7-regulate-SIRT7', 'FBXO7-suppress-SIRT7', 'BRCA1-compare-BRCA2', 'BRCA1-carry-BRCA2', 'DR1-involved-NFE2L2', 'PRX-suppress-DR1', 'HAPLN1-detected-NCAN', 'DR1-reduce ROS production by-NFE2L2', 'BCAN-detected-NCAN', 'ACAN-detected-NCAN', 'CD8A-show shrinkage-CD4', 'CXCL9-associated-CD4', 'CD4-associated-CXCL9', 'TXNIP-modulate-CDKN2A', 'Cardiovascular Diseases-drive-Aortic Valve Stenosis', 'Alzheimer Disease-defined-Central Nervous System Diseases', 'Sepsis-regarded-Hematologic Neoplasms', 'Hantavirus Pulmonary Syndrome-influence-Cardiovascular Diseases', 'Sepsis-modulated-Multiple Organ Failure', 'Alzheimer Disease-reflect-Nerve Degeneration', 'Dementia-lead-Autoimmune Diseases', 'Asthma-discuss-Inflammation', 'Metabolic Syndrome-characterized-Inflammation', 'Pneumonia-manage-Asthma', 'Genetic Diseases, Inborn-contribute-Hypertension', 'Genetic Diseases, Inborn-contribute-Coronary Artery Disease', 'Genetic Diseases, Inborn-contribute-Stroke', 'Metabolic Syndrome-include-Communicable Diseases', 'Osteoporosis-affect-Neoplasms', 'Osteoporosis-affect-Stroke', 'Arthritis-disable-Neoplasms', 'Arthritis-affect-Stroke', 'Neurologic Manifestations-associated-Sleep Initiation and Maintenance Disorders', 'Sleep Initiation and Maintenance Disorders-associated-Neurologic Manifestations', 'Wounds and Injuries-characterize-Brain Injuries, Traumatic', 'Arthritis-develop-Heart Diseases', 'Arthritis-develop-Stroke', 'Heart Diseases-develop-Stroke', 'Tuberculosis, Pulmonary-associated-Pulmonary Disease, Chronic Obstructive', 'Pulmonary Disease, Chronic Obstructive-associated-Tuberculosis, Pulmonary', 'Neurosyphilis-accentuate-Stroke', 'Bacterial Infections-pose-Death', 'Bacterial Infections-pose-Infections', 'Infections-pose-Death', 'Epilepsy-afflict-Neoplasms', 'Obesity-cause-Hypertrophy', 'Proteinuria-occur-Renal Insufficiency', 'Renal Insufficiency, Chronic-determine-Hypertension', 'Hypertension-predict-Atrial Fibrillation', 'Hypertension-predict-Kidney Failure, Chronic', 'Atrial Fibrillation-predict-Kidney Failure, Chronic', 'Metabolic Syndrome-lead-Dementia', 'Hyperglycemia-associated-Dementia', 'Dementia-associated-Hyperglycemia', 'Hyperglycemia-lead-Dementia', 'Dyslipidemias-lead-Dementia', 'Obesity, Abdominal-lead-Dementia', 'Diabetes Mellitus-related-Adenomatous Polyposis Coli', 'Syncope-include-Hypotension, Orthostatic', 'Inflammation-named-Death', 'Hyperoxia-compared-Death', 'Death-compared-Hyperoxia', 'Inflammation-associated-Drug-Related Side Effects and Adverse Reactions', 'Drug-Related Side Effects and Adverse Reactions-associated-Inflammation', 'Periodontitis-result-Dysbiosis', 'Periodontitis-address-Neoplasms', 'Periodontitis-cause-Periodontal Diseases', 'Hypogonadism-associated-Sarcopenia', 'Sarcopenia-associated-Hypogonadism', 'Dwarfism, Pituitary-associated-Sarcopenia', 'Sarcopenia-associated-Dwarfism, Pituitary', 'Coronary Artery Disease-promote-Atherosclerosis', 'Contracture-cause-Wounds and Injuries', 'Thyroid Neoplasms-exhibit-Cardiovascular Diseases', 'Contracture-cause-Arthritis', 'Contracture-regarded-Fibrosis', 'Contracture-cause-Fibrosis', 'Bone Marrow Diseases-show-Fibrosis', 'Fibrosis-exacerbate-Contracture', 'Pain-indicate-Pain Insensitivity, Congenital', 'Pain-indicate-Hypotension', 'Pain-indicate-Nausea', 'Pain-indicate-Vomiting', 'Sarcopenia-associated-Blepharoptosis', 'Blepharoptosis-associated-Sarcopenia', 'Sarcopenia-related-Blepharoptosis', 'Sarcopenia-confer-Obesity', 'Obesity-include-Sarcopenia', 'Inflammation-modulated-Death', 'Kidney Diseases-detect-Renal Insufficiency', 'Polycystic Ovary Syndrome-include-Hyperandrogenism', 'Polycystic Ovary Syndrome-include-Puberty, Delayed', 'Neoplasms-become-Arthritis, Rheumatoid', 'Neoplasms-interfere-Arthritis, Rheumatoid', 'Autoimmune Diseases-cause-Rheumatic Diseases', 'Autoimmune Diseases-exacerbate-Arthritis', 'Autoimmune Diseases-exacerbate-Myositis', 'Autoimmune Diseases-exacerbate-Vasculitis', 'Rheumatic Diseases-cause-Arthritis', 'Rheumatic Diseases-cause-Myositis', 'Rheumatic Diseases-cause-Vasculitis', 'Arthritis-termed-Rheumatic Diseases', 'Myositis-termed-Rheumatic Diseases', 'Immunologic Deficiency Syndromes-result-Bone Neoplasms', 'Vasculitis-termed-Rheumatic Diseases', 'Osteoporosis-result-Bone Diseases', 'Dysbiosis-initiate-Inflammation', 'Dysbiosis-interrupted-Neoplasms', 'Dysbiosis-interrupted-Irritable Bowel Syndrome', 'Dysbiosis-interrupted-Inflammatory Bowel Diseases', 'Inflammation-avoid-Neoplasms', 'Liver Cirrhosis, Biliary-begin-Bile Duct Diseases', 'Liver Diseases-begin-Bile Duct Diseases', 'Liver Cirrhosis-followed-Liver Diseases', 'Fibrosis-followed-Liver Diseases', 'Bile Duct Diseases-followed-Liver Cirrhosis', 'Bile Duct Diseases-followed-Fibrosis', 'Cystic Fibrosis-range-Respiratory Tract Infections', 'Cystic Fibrosis-range-Inflammation', 'Neurologic Manifestations-impair-Infections', 'Hypotension-performed-Hematoma', 'Atrial Fibrillation-affected-Cardiovascular Diseases', 'Rheumatic Fever-associated-Pain', 'Pain-associated-Rheumatic Fever', 'Brain Diseases-associated-Pain', 'Pain-associated-Brain Diseases', 'Lung Diseases-associated-Pain', 'Pain-associated-Lung Diseases', 'Pain-include-Rheumatic Fever', 'Pain-include-Brain Diseases', 'Delirium-cause-Brain Diseases', 'Stroke-transformed-Hypertension', 'Stroke-change-Hypertension', 'Chronic Disease-associated-Asthma', 'Asthma-associated-Chronic Disease', 'Neoplasms-associated-Hearing Loss', 'Hearing Loss-associated-Neoplasms', 'Hypertension-mediated-Aneurysm', 'Hypertension-considered-Aneurysm', 'Carcinoma, Hepatocellular-develop-Liver Cirrhosis', 'Fibrosis-develop-Liver Cirrhosis', 'Hypertension, Pulmonary-avoid-Ventricular Dysfunction', 'Fatigue-recorded-Fractures, Bone', 'Myotonic Dystrophy-recommended-Cardiovascular Diseases', 'Ovarian Neoplasms-make-Genital Neoplasms, Male', 'Cardiovascular Diseases-score-Seizures', 'Wounds and Injuries-increased-Lung, Hyperlucent', 'Neoplasms-shed-Cardiovascular Diseases', 'Infarction-include-Heart Diseases', 'Opportunistic Infections-qualify-Acquired Immunodeficiency Syndrome', 'Hypercalcemia-detected-Hypervitaminosis A', 'Hypercalcemia-result-Death', 'Pneumonia-followed-Cerebral Infarction', 'Pneumonia-followed-Diabetes Mellitus', 'Pneumonia-followed-Neoplasms', 'Ventricular Fibrillation-evaluate-Pneumonia, Aspiration', 'Sarcopenia-determined-Adenomatous Polyposis Coli', 'Metabolic Syndrome-associated-Neurodegenerative Diseases', 'Neurodegenerative Diseases-associated-Metabolic Syndrome', 'Heart Failure-comprise-Mitochondrial Diseases', 'Heart Failure-comprise-Inflammation', 'Cerebral Infarction-inactivate-Inflammation', 'Alzheimer Disease-inactivate-Inflammation', 'Parkinson Disease-inactivate-Inflammation', 'Alzheimer Disease-follow-Dementia', 'Mitochondrial Diseases-established-Alzheimer Disease', 'Neurologic Manifestations-cause-Hyperoxia', 'Neurologic Manifestations-increase-Hyperoxia', 'Death-base-Malocclusion', 'Death-ascertained-Malocclusion', 'Bronchopulmonary Dysplasia-include-Hyperoxia', 'Mitochondrial Diseases-include-Hyperoxia', 'Neoplasms-display-Pancreatic Neoplasms', 'Neoplasms-display-Lung Neoplasms', 'Lung Neoplasms-falls-Death', 'Death-fit-Neoplasms', 'Sleep Wake Disorders-contribute-Neurodegenerative Diseases', 'Dysbiosis-associated-Alzheimer Disease', 'Alzheimer Disease-associated-Dysbiosis', 'Small Fiber Neuropathy-follow-Demyelinating Diseases', 'Hemorrhage-include-Stroke', 'Chronic Kidney Disease-Mineral and Bone Disorder-experience-Infections', 'Periodontitis-exacerbate-Inflammation', 'Pulmonary Disease, Chronic Obstructive-found-Infections', 'Kidney Diseases-found-Infections', 'Hypertension-decrease-Dementia', 'Mouth Diseases-monitor-Periodontitis', 'Obesity-compare-Skin Diseases', 'Arthritis, Rheumatoid-associated-Blood Loss, Surgical', 'Blood Loss, Surgical-associated-Arthritis, Rheumatoid', 'Arthritis, Rheumatoid-stay-Blood Loss, Surgical', 'Arthritis, Rheumatoid-appear-Hip Fractures', 'Sarcopenia-obtained-Ataxia', 'Respiratory Tract Diseases-associated-Muscular Atrophy', 'Muscular Atrophy-associated-Respiratory Tract Diseases', 'Cold Injury-cause-Death', 'Muscular Atrophy-associated-Death', 'Death-associated-Muscular Atrophy', 'Cold Injury-avoid-Death', 'Drug Overdose-result-Neurotoxicity Syndromes', 'Neurotoxicity Syndromes-described-Brain Injuries', 'Drug-Related Side Effects and Adverse Reactions-compare-Breast Neoplasms', 'Drug Overdose-use-Death', 'Muscular Diseases-contribute-Sarcopenia', 'Drug Eruptions-remove-Drug-Related Side Effects and Adverse Reactions', 'Drug Eruptions-relieve-Pharyngeal Diseases', 'Drug-Related Side Effects and Adverse Reactions-relieve-Pharyngeal Diseases', 'Dyspnea-treat-Cold Injury', 'Cough-treat-Cold Injury', 'Pharyngeal Diseases-treat-Cold Injury', 'Death-used-Dementia', 'Glycogen Storage Disease Type II-reduce-Vision, Low', 'Glycogen Storage Disease Type II-affect-Diabetes Mellitus', 'Mastocytosis, Systemic-influence-Glycogen Storage Disease Type II', 'Communicable Diseases-represent-Death', 'Psoriasis-manifest-Erythema', 'Pain-prescribed-Back Pain', 'Leukemia, Myeloid, Acute-combine-Hypertension', 'Leukemia, Myeloid, Acute-combine-Obesity', 'Leukemia, Myeloid, Acute-combined-Hypertension', 'Hypotension-linked-Critical Illness', 'Hypotension-linked-Neoplasms', 'Hypotension-linked-Musculoskeletal Diseases', 'Hypotension-linked-Lung Diseases', 'Hypotension-linked-Osteomalacia', 'Critical Illness-result-Osteomalacia', 'Neoplasms-result-Osteomalacia', 'Musculoskeletal Diseases-result-Osteomalacia', 'Neurogenic Inflammation-enhanced-Alzheimer Disease', 'Lung Diseases-result-Osteomalacia', 'Sclerosis-described-Brain Injuries, Traumatic', 'Sclerosis-described-Neurodegenerative Diseases', 'Sclerosis-linked-Tooth, Impacted', 'TDP-43 Proteinopathies-described-Brain Injuries, Traumatic', 'TDP-43 Proteinopathies-described-Neurodegenerative Diseases', 'TDP-43 Proteinopathies-linked-Tooth, Impacted', 'Brain Injuries, Traumatic-linked-Tooth, Impacted', 'Neurodegenerative Diseases-linked-Tooth, Impacted', 'Infections-develop-Venous Thromboembolism', 'Fibrosis-deposit-Multiple Organ Failure', 'Glaucoma-represent-Optic Nerve Diseases', 'Obesity-describe-Inflammation', 'Bone Neoplasms-associated-Tooth Loss', 'Tooth Loss-associated-Bone Neoplasms', 'Sarcopenia-begin-Malnutrition', 'Sarcopenia-studied-Infections', 'Sarcopenia-consider-Cardiovascular Diseases', 'Immunologic Deficiency Syndromes-affect-Neurodegenerative Diseases', 'Immunologic Deficiency Syndromes-affect-Diabetes Mellitus', 'Immunologic Deficiency Syndromes-result-Nervous System Diseases', 'Immunologic Deficiency Syndromes-characterised-Nervous System Diseases', 'Deglutition Disorders-associated-Postpartum Hemorrhage', 'Postpartum Hemorrhage-associated-Deglutition Disorders', 'Li-Fraumeni Syndrome-consider-Neoplasms', 'Neoplasms-become-Dementia', 'Dementia-affect-Neoplasms', 'Death-compare-Epilepsy, Absence', 'Diastema-present-Fractures, Bone', 'Dysentery-lead-Dehydration', 'Dysentery-lead-Death', 'Sarcoma, Kaposi-remain-Neoplasms', 'Cardiovascular Diseases-occur-Thyroid Diseases', 'Dementia-live-HIV Infections', 'Yin Deficiency-treat-Muscle Weakness', 'Sleep Initiation and Maintenance Disorders-treat-Muscle Weakness', 'Renal Insufficiency, Chronic-undergo-Diabetic Nephropathies', 'Diabetes Mellitus-increase-Obesity, Abdominal', 'Pulmonary Disease, Chronic Obstructive-associated-Signs and Symptoms, Respiratory', 'Signs and Symptoms, Respiratory-associated-Pulmonary Disease, Chronic Obstructive', 'Sarcopenia-characterized-Liver Cirrhosis', 'Sarcopenia-characterized-Non-alcoholic Fatty Liver Disease', 'Sarcopenia-characterized-Diabetes Mellitus', 'Liver Cirrhosis-characterized-Non-alcoholic Fatty Liver Disease', 'Non-alcoholic Fatty Liver Disease-characterized-Diabetes Mellitus', 'Kidney Failure, Chronic-require-Death', 'Arthritis, Rheumatoid-compared-Arthritis, Psoriatic', 'Neoplasms-recommended-Prostatitis', 'Neoplasms-recommended-Glioblastoma', 'Hepatitis B-receive-Autoimmune Diseases', 'Inflammation-invoked-Neurodegenerative Diseases', 'Pain-associated-Headache Disorders, Secondary', 'Headache Disorders, Secondary-associated-Pain', 'Fatigue-subjected-Fractures, Bone', 'Leg Ulcer-associated-Hypertension', 'Hypertension-associated-Leg Ulcer', 'Cataract-increase-Dementia', 'Cataract-increase-Alzheimer Disease', 'Cataract-reverse-Dementia', 'Delirium-associated-Psychoses, Substance-Induced', 'Psychoses, Substance-Induced-associated-Delirium', 'Hearing Loss-associated-Mucopolysaccharidosis III', 'Mucopolysaccharidosis III-associated-Hearing Loss', 'Mucopolysaccharidosis III-associated-Tinnitus', 'Tinnitus-associated-Mucopolysaccharidosis III', 'Death-mitigate-Communicable Diseases', 'Wounds and Injuries-live-HIV Infections', 'Myocardial Infarction-followed-Pneumonia, Aspiration', 'Neoplasms-followed-Pneumonia, Aspiration', 'Gastrointestinal Hemorrhage-followed-Pneumonia, Aspiration', 'Stroke-followed-Pneumonia, Aspiration', 'Pulmonary Embolism-followed-Pneumonia, Aspiration', 'Acute Kidney Injury-followed-Pneumonia, Aspiration', 'Proteostasis Deficiencies-occur-Neurodegenerative Diseases', 'Proteostasis Deficiencies-involved-Neurodegenerative Diseases', 'Heart Failure-fail-Death', 'Diabetes Mellitus-rise-Obesity', 'Diabetes Mellitus-exhibit-Cardiovascular Diseases', 'Diabetes Mellitus-exhibit-Myocardial Infarction', 'Diabetes Mellitus, Type 2-accelerate-Hyperglycemia', 'Diabetes Mellitus, Type 2-accelerate-Hyperinsulinism', 'Hypotension-remark-Heart Failure', 'Fractures, Bone-remark-Heart Failure', 'Diabetes Mellitus-remark-Heart Failure', 'Heredodegenerative Disorders, Nervous System-outline-Alzheimer Disease', 'Heredodegenerative Disorders, Nervous System-outline-Parkinson Disease', 'Osteoarthritis-follow-Fractures, Bone', 'Fractures, Bone-overcome-Tibial Fractures', 'Cholesterol-rendered-Inflammation', 'TRPV1-reduce-Inflammation', 'SIRT6-use-Arginine Vasopressin', 'DYRK1A-reflect-Alzheimer Disease', 'DYRK1A-correlated-Alzheimer Disease', 'DYRK1A-detected-Tauopathies', 'ADIPOQ-reduce-Inflammation', 'MAPT-involve-Alzheimer Disease', 'ADIPOQ-quantify-Inflammation', 'GPER1-associated-Alzheimer Disease', 'Alzheimer Disease-associated-GPER1', 'YBX1-provide-Osteoporosis', 'GPER1-examine-Alzheimer Disease', 'SIRT1-linked-Osteoarthritis', 'TXNIP-impair-Glucose Metabolism Disorders', 'EZH2-implicated-Inflammation', 'ERBB2-downloaded-Neoplasms', 'CLU-associated-Nerve Degeneration', 'Nerve Degeneration-associated-CLU', 'AGRN-investigated-Muscle Weakness', 'CSF1-involved-Dementia', 'AGRN-shown-Renal Insufficiency, Chronic', 'CRP-show-Infections', 'YPEL2-promote-Atherosclerosis', 'SPP1-played-Drug Hypersensitivity', 'SIRT6-play-Inflammation', 'SPP1-used-Inflammation', 'SIRT6-link-Inflammation', 'SIRT6-reduced-Obesity', 'NEFL-related-Neurodegenerative Diseases', 'FGF19-described-Sarcopenia', 'NEFL-serve-Stroke', 'NEFL-associated-Brain Infarction', 'Brain Infarction-associated-NEFL', 'Seizures-display-GDF11', 'WNT3-mitigate-Fibrosis', 'Sepsis-associated-CRP', 'CRP-associated-Sepsis', 'PCYT2-link-Muscular Dystrophies', 'MGMT-assessed-Glioblastoma', 'MGMT-implicate-Glioblastoma', 'NLRP3-develop-Chronic Disease', 'ERCC1-associated-Ventricular Remodeling', 'Ventricular Remodeling-associated-ERCC1', 'Progeria-derived-LMNA', 'GFAP-increased-Alzheimer Disease', 'GFAP-present-Dementia', 'SDHC-recognized-Neoplasms', 'Communicable Diseases-impact-BANF1', 'NOTCH3-accumulate-Obesity', 'BANF1-present-Muscle Weakness', 'TUG1-associated-HIV Infections', 'HIV Infections-associated-TUG1', 'Myotonic Dystrophy-diagnosed-Glucose', 'Glucose-classified-Diabetes Mellitus', 'Capsaicin-associated-Gastrointestinal Diseases', 'Gastrointestinal Diseases-associated-Capsaicin', 'Capsaicin-compare-Gastrointestinal Diseases', 'Glutathione-diminish-Alzheimer Disease', 'Receptor-CD3 Complex, Antigen, T-Cell-changing-Infections', 'TNF-be related Among-CLOCK', 'Cholesterol-associated-Fatty Acids', 'Fatty Acids-associated-Cholesterol', 'SEPTIN9-determine-ALPP', 'SEPTIN9-determine-ALB', 'BLMH-involved-FLG', 'rs1990622-predispose to-TMEM106B', 'PGR-target-MMP7', 'PGR-target-MUC16', 'CAT-correlated-DAO', 'Glutathione-correlated-CAT', 'VEGFA-echinomycin-MAPK1', 'VEGFA-KD-MAPK1', 'MTOR-catalyze-AKT1', 'Fatty Acids-induce-EIF2AK3', 'Echinomycin-decrease-VEGFA', 'Palmitates-induce-EIF2AK3', 'MTOR-catalyze-TFEB', 'MTOR-catalyze-RPS6KB1', 'APOE-related-MAPT', 'APOE-carry-MAPT', 'APOE-identify-rs146766120', 'APOE-identify-rs111522866', 'APOE-carry-rs63751438', 'MIR34A-modulate LEC apoptosis development through-HK1', 'MIR34A-modulate LEC apoptosis development through-CASP3', 'PRKN-181c-SMAD7', 'Inositol-include-MTOR', 'PVT1-sequester-AQP3', 'AQP3-inactivate-MAPK1', 'THBS1-explore-GZMB', 'THBS1-explore-Cyclosporine', 'GZMB-explore-Cyclosporine', 'Cyclosporine-increased-GZMB', 'Glyceraldehyde-catalyze-GAPDH', 'GAPDH-catalyze-Diphosphoglyceric Acids', 'LCN2-correlate-Triglycerides', 'LCN2-correlate-Cholesterol', 'Phosphatidylinositols-belong-Lactosylceramides', 'FGF23-regulate-NFE2L2', 'FGF23-regulate-MTOR', 'RINL-regulate-CD28', 'FABP3-tend-FABP7', 'FABP3-tend-FABP5', 'BFSP2-interact-ATM', 'DUOX1-show-IFI30', 'IFI30-express-PRODH', 'IFI30-express-P2RX1', 'NLRP3-show-DUOX1', 'DUOX1-express-PRODH', 'DUOX1-express-P2RX1', 'NLRP3-express-PRODH', 'NLRP3-express-P2RX1', 'P2RX1-express-PRODH', 'LAMA2-related-CD4', 'NID2-related-CD4', 'SOX17-drive iNSC reprogramming-SOX2', 'DDIT3-integration-FOXO3', 'PANX1-rejuvenate-CDKN1A', 'PANX1-rejuvenate-TP53', 'CSTB-modulate-CTSB', 'KL-associated-CD4', 'CD4-associated-KL', 'SPHK1-lost-KLF12', 'DHFR-knock-E2F1', 'E2F1-bind-DHFR', 'GIGYF2-enhance-STAU1', 'ITGA4-up-regulated-CX3CL1', 'RECQL4-ubiquitylated-MARCHF5', 'RECQL4-hyper-ubiquitylated-MARCHF5', 'SIRT5-found-SIRT6', 'SIRT3-found-SIRT6', 'SIRT4-found-SIRT6', 'SPP1-increased-CRP', 'ATM-phosphorylate-APOE', 'MMP1-activated-EGFR', 'RPL15-correlate-SPP1', 'RPL18-correlate-SPP1', 'ASPM-restore-PRKCA', 'NR4A2-promote-TMPRSS2', 'NR4A2-promote-ACE2', 'GPR65-include-CREB1', 'GPR4-include-CREB1', 'EP300-known-CREBBP', 'P4HB-decrease-SERPINE1', 'SLC3A2-increased-GPX4', 'NCOA4-increased-GPX4', 'TFRC-increased-GPX4', 'MAPT-evaluate-NEFL', 'MAPT-evaluate-GFAP', 'CDC42-switch-ARHGAP1', 'MYC-reprogram-POU5F1', 'KLF4-reprogram-POU5F1', 'SOX2-reprogram-POU5F1', 'LIN28A-reprogram-POU5F1', 'SESN1-safeguard-FOXO3', 'CDC37-interact-HSP90AA1', 'NFE2L2-decrease-RELA', 'NFE2L2-decrease-ACAN', 'METTL3-identify-NPNT', 'TMEM106B-implicate-GRN', 'TMEM106B-implicate-TARDBP', 'CCL2-reveal-CCL3', 'METTL3-regulate-SIRT1', 'GNRH1-mediated-GNRHR', 'NOX4-suggest-SPP1', 'NOX4-suggest-MPO', 'GDF15-associated-CST3', 'CST3-associated-GDF15', 'TLR3-promote-IFNA1', 'XYLT1-required-TLR3', 'PRPF31-warrant-RPGR', 'HK1-warrant-PRPF31', 'CDKN1A-increased-MMP1', 'CDKN1A-decreased-COL1A1', 'COL1A1-increased-MMP1', 'ZFP82-suggest-MC1R', 'PIK3IP1-suggest-MC1R', 'LRP4-suggest-MC1R', 'THBS1-identified-GZMB', 'PDGFRA-mark-TAGLN', 'VIM-mark-TAGLN', 'DPEP1-mark-TAGLN', 'Saponins-prevent-Ginsenosides', 'Menthol-increase-Cardiolipins', 'Menthol-regulate-Cardiolipins', 'Cholesterol-stored-Cholesterol Esters', 'MIR494-reveal-SIRT1', 'HK1-targeted-MIR34A', 'MT-TG-associated-INS', 'INS-associated-MT-TG', 'Glucose-increase-BDNF', 'LCT-digest-Lactose', 'ALDH2-associated-Cholesterol', 'Cholesterol-associated-ALDH2', 'CDKN2A-rescue-Erythritol', 'Bleomycin-shown-EPAS1', 'VDR-mediate-Calcitriol', 'EPHX2-convert-Fatty Acids', 'HRG-belong-Salivary Cystatins', 'NHP2-reveal-rs559884313', 'rs1274412848-exhibit-PCNA', 'FLT1-associated-rs3794396', 'rs3794396-associated-FLT1', 'rs1990622-associated-TMEM106B', 'TMEM106B-associated-rs1990622', 'Breast Neoplasms-diagnosed-BRCA2', 'Breast Neoplasms-diagnosed-BRCA1', 'BRCA1-compared-BRCA2', 'BRCA1-compared-RAD51D', 'BRCA1-compared-RAD51C', 'BRCA1-compared-BRIP1', 'BRCA1-compared-PALB2', 'BRCA2-compared-RAD51D', 'BRCA2-compared-RAD51C', 'BRCA2-compared-BRIP1', 'BRCA2-compared-PALB2', 'BRCA1-compared-Neoplasms', 'BRCA2-compared-Neoplasms', 'INS-be in-Diabetes Mellitus, Type 2', 'MTMR2-be important promoter by-STAT1', 'MTMR2-be important promoter in-Stomach Neoplasms', 'HIV Infections-disturbed-CD8A', 'HIV Infections-disturbed-CD4', 'CD8A-decrease-HIV Infections', 'CD4-decrease-HIV Infections', 'RARRES2-compare-Kidney Failure, Chronic', 'rs17173608-compare-Kidney Failure, Chronic', 'Ovarian Neoplasms-develop-Neoplasms', 'BRCA1-develop-Neoplasms', 'TNFRSF11B-be soluble receptor of-TNFSF10', 'HIV Infections-live-CD8A', 'HIV Infections-live-CD4', 'BRCA2-develop-Neoplasms', 'Alstrom Syndrome-characterise-Obesity', 'FOXO3-associated-TNF', 'TNF-associated-FOXO3', 'Alstrom Syndrome-characterise-Fatty Liver', 'Alstrom Syndrome-characterise-Diabetes Mellitus', 'Polycystic Ovary Syndrome-compare-Diabetes Mellitus', 'KRAS-tested-Lung Neoplasms', 'Polycystic Ovary Syndrome-result-Death', 'EGFR-tested-Lung Neoplasms', 'Breast Neoplasms-used-BRCA1', 'Breast Neoplasms-used-BRCA2', 'Genetic Diseases, Inborn-characterise-Obesity', 'RET-highlight-CCDC6', 'Genetic Diseases, Inborn-characterise-Fatty Liver', 'CTLA4-considered-MALT1', 'Neoplasms-highlight-Thyroid Carcinoma, Anaplastic', 'ICAM1-associated-TNF', 'TNF-associated-ICAM1', 'Genetic Diseases, Inborn-characterise-Diabetes Mellitus', 'FOXP3-considered-MALT1', 'RET-highlight-Thyroid Carcinoma, Anaplastic', 'Neoplasms-highlight-RET', 'Neoplasm Metastasis-suggest-PTEN', 'Thyroid Carcinoma, Anaplastic-highlight-CCDC6', 'Neoplasms-highlight-CCDC6', 'Neoplasm Metastasis-suggest-EGFR', 'Alstrom Syndrome-characterise-INS', 'MALT1-considered-Immunologic Deficiency Syndromes', 'Genetic Diseases, Inborn-characterise-INS', 'INS-related-RETN', 'Glucose-related-RETN', 'INS-related-Inflammation', 'BRCA1-diagnosed-Breast Neoplasms', 'Glucose-related-Inflammation', 'GADD45A-associated-TNF', 'TNF-associated-GADD45A', 'BRCA2-diagnosed-Breast Neoplasms', 'BIRC3-associated-TNF', 'TNF-associated-BIRC3', 'HFE-predict-Death', 'HFE-predict-Diabetes Mellitus, Type 1', 'TF-predict-Death', 'RELB-associated-TNF', 'TNF-associated-RELB', 'TF-predict-Diabetes Mellitus, Type 1', 'rs1800562-predict-Death', 'rs1800562-predict-Diabetes Mellitus, Type 1', 'AREG-associated-TNF', 'TNF-associated-AREG', 'SESN2-associated-TNF', 'TNF-associated-SESN2', 'BBC3-associated-TNF', 'TNF-associated-BBC3', 'MYC-associated-TNF', 'TNF-associated-MYC', 'EGR1-associated-TNF', 'TNF-associated-EGR1', 'CXCL8-associated-TNF', 'TNF-associated-CXCL8', 'SGK1-associated-TNF', 'TNF-associated-SGK1', 'MTHFD2-associated-TNF', 'TNF-associated-MTHFD2', 'rs104894584-increase-Arrhythmias, Cardiac', 'XPO5-be in-Esophageal Squamous Cell Carcinoma', 'SIRT1-activate-TP53', 'Neoplasms-suggest-Esophageal Squamous Cell Carcinoma', 'SIRT1-Treatment with-Glucose', 'SIRT1-decrease-Glucose', 'Glucose-activate-TP53', 'VEGFA-assess-Acromegaly', 'Neoplasms-suggest-XPO5', 'Death-be in-Acromegaly', 'Death-depend on-GGH', 'Acromegaly-depend-GGH', 'Death-depend-IGF1', 'Acromegaly-depend-IGF1', 'CRP-measured-Cystic Fibrosis', 'AXL-related-AXIN2', 'SOD2-represent-Neoplasms', 'SOD2-represent-Prostatic Neoplasms', 'GPX1-represent-Neoplasms', 'GPX1-represent-Prostatic Neoplasms', 'AXL-related-Leukemia, Promyelocytic, Acute', 'BRCA1-undergo-Neoplasms', 'PEBP1-associated-MACC1', 'MACC1-associated-PEBP1', 'BRCA2-undergo-Neoplasms', 'PEBP1-associated-Colorectal Neoplasms', 'Colorectal Neoplasms-associated-PEBP1', 'ARF6-regulate-Breast Neoplasms', 'JAK2-combined-EPO', 'Polycythemia Vera-defined-JAK2', 'Polycythemia Vera-combined-EPO', 'CDC25C-include-Neoplasms', 'CDK1-include-Neoplasms', 'MCM2-include-Neoplasms', 'PLK1-include-Neoplasms', 'Melanoma-characterised-GNAQ', 'CRP-identify-Neoplasms', 'Melanoma-characterised-GNA11', 'COMT-subjected-Neoplasms', 'Melanoma-characterised-MAPK1', 'HTR2A-subjected-Neoplasms', 'ADIPOQ-measured-Hyperparathyroidism, Secondary', 'COMT-expressed-Carcinogenesis', 'PRODH-subjected-Neoplasms', 'LEP-measured-Hyperparathyroidism, Secondary', 'COMT-expressed-Neoplasms', 'HTR2A-expressed-Carcinogenesis', 'HTR2A-expressed-Neoplasms', 'Carcinoma, Non-Small-Cell Lung-be with-EGFR', 'ARHGAP24-induced-ARF6', 'Neoplasms-induced-ARF6', 'SHBG-appear-INS', 'Diabetes Mellitus-compare-INS', 'SHBG-appear-Diabetes Mellitus', 'HNF1A-lead-INS', 'Fetal Macrosomia-lead-Diabetes Mellitus', 'HNF1A-lead-Diabetes Mellitus', 'Fetal Macrosomia-lead-INS', 'Diabetes Mellitus-lead-INS', 'ZFAND2A-identify-BIRC3', 'ZFAND2A-identify-Melanoma', 'rs1800795-be in-Non-alcoholic Fatty Liver Disease', 'EGFR-used-ERBB2', 'EGFR-used-Neoplasms', 'EGFR-treat-Neoplasms', 'ERBB2-used-Neoplasms', 'ERBB2-treat-Neoplasms', 'PKD2-regarded-Neoplasms', 'PKD1-regarded-Neoplasms', 'Adenomatous Polyposis Coli-predispose-Neoplasms', 'CTLA4-include-Brain Neoplasms', 'von Hippel-Lindau Disease-predispose-Neoplasms', 'Neoplasms-treat-Carcinoma, Non-Small-Cell Lung', 'TGFBR2-suspected-Marfan Syndrome', 'FBN1-suspected-Marfan Syndrome', 'Arthritis, Rheumatoid-determine-Osteosarcoma', 'Coronary Artery Disease-lower rates-Myocardial Infarction', 'Coronary Artery Disease-RESULTS-Myocardial Infarction', 'Coronary Artery Disease-lower rates-Stroke', 'Coronary Artery Disease-RESULTS-Stroke', 'TP53-be significant prognostic factors for-Death', 'TP53-proliferate-PCNA', 'Prostatic Neoplasms-down-regulate-PTK2', 'Neoplasms-show-PCNA', 'PCNA-be significant prognostic factors for-Death', 'Prostatic Neoplasms-impair-VEGFA', 'Coronary Artery Disease-RESULTS OF-SLC5A2', 'Prostatic Neoplasms-impair-CCND1', 'TP53-evaluate-Urinary Bladder Neoplasms', 'PCNA-offer-Urinary Bladder Neoplasms', 'TP53-offer-Urinary Bladder Neoplasms', 'Neoplasms-provide-BRCA2', 'TP53-proliferate status in-Neoplasms', 'TP53-evaluate-Neoplasms', 'Neoplasms-investigated-TP53', 'Neoplasms-investigated-BCL2', 'PCNA-correlate-Urinary Bladder Neoplasms', 'KLRG1-increased-Tuberculosis', 'ADIPOQ-correlated-INS', 'Neoplasms-provide-BRCA1', 'Neoplasms-investigated-PCNA', 'PCNA-correlate-Neoplasms', 'AKT1-induce-Prostatic Neoplasms', 'CD4-drive-KLRG1', 'BRCA1-gain-Neoplasms', 'KLRG1-restrained-Tuberculosis', 'Inflammation-associated-FGF23', 'FGF23-associated-Inflammation', 'Iron Metabolism Disorders-associated-FGF23', 'FGF23-associated-Iron Metabolism Disorders', 'BRCA2-gain-Neoplasms', 'KLRG1-drive-Infections', 'Inflammation-associated-LCN2', 'LCN2-associated-Inflammation', 'Iron Metabolism Disorders-associated-LCN2', 'LCN2-associated-Iron Metabolism Disorders', 'Huntington Disease-assigned-Enoxaparin', 'Huntington Disease-assigned-Heparin', 'Heparin, Low-Molecular-Weight-tolerate-Heparin', 'ESR2-associated-Metabolic Syndrome', 'Metabolic Syndrome-associated-ESR2', 'Heparin, Low-Molecular-Weight-tolerate-Venous Thrombosis', 'Hemorrhage-reduce-Acute Coronary Syndrome', 'Death-compare-Acute Coronary Syndrome', 'Death-reduce-Acute Coronary Syndrome', 'ESR1-associated-Metabolic Syndrome', 'Metabolic Syndrome-associated-ESR1', 'Fondaparinux-reduce-Hemorrhage', 'Heparin-tolerate-Venous Thrombosis', 'Fondaparinux-reduce-Death', 'CCL5-increase-Heparin', 'rs2234693-associated-Metabolic Syndrome', 'Metabolic Syndrome-associated-rs2234693', 'Fondaparinux-reduce-Acute Coronary Syndrome', 'CCL5-increase-Huntington Disease', 'Hemorrhage-compare-Enoxaparin', 'Hemorrhage-reduce-Enoxaparin', 'rs6902771-associated-Metabolic Syndrome', 'Metabolic Syndrome-associated-rs6902771', 'Enoxaparin-appear-Fondaparinux', 'rs7774230-associated-Metabolic Syndrome', 'Metabolic Syndrome-associated-rs7774230', 'Death-compare-Enoxaparin', 'Death-reduce-Enoxaparin', 'rs3020449-associated-Metabolic Syndrome', 'Metabolic Syndrome-associated-rs3020449', 'Enoxaparin-be in-Acute Coronary Syndrome', 'Enoxaparin-examine-Heparin', 'Enoxaparin-examine-Myocardial Infarction', 'Enoxaparin-used-Heparin', 'Heparin, Low-Molecular-Weight-evaluate-Heparin', 'Heparin, Low-Molecular-Weight-include-Heparin', 'Fondaparinux-include-Heparin', 'Enoxaparin-demonstrate-Death', 'Enoxaparin-demonstrate-Myocardial Infarction', 'Neoplasms-include-Heparin', 'Myocardial Infarction-used-Enoxaparin', 'Death-used-Enoxaparin', 'Heparin-base-Enoxaparin', 'Myocardial Infarction-used-Heparin', 'Myocardial Infarction-base-Enoxaparin', 'Venous Thromboembolism-compare-Heparin', 'Death-used-Heparin', 'Venous Thromboembolism-compare-Fondaparinux', 'Fatty Acids, Unsaturated-prevent-Chronic Disease', 'Heparin-be in-Myocardial Infarction', 'Fatty Acids, Omega-3-prevent-Chronic Disease', 'Obesity-compare-Triglycerides', 'Lipodystrophy-be in-HIV Infections', 'Exenatide-associated-Insulin Glargine', 'Insulin Glargine-associated-Exenatide', 'Exenatide-associated-INS', 'INS-associated-Exenatide', 'Coronary Artery Disease-raise-Triglycerides', 'Glucose-associated-Diabetes Mellitus, Type 1', 'Diabetes Mellitus, Type 1-associated-Glucose', 'INS-study-Obesity', 'INS-investigate-Diabetes Mellitus, Type 2', 'Exenatide-investigate-Diabetes Mellitus, Type 2', 'Insulin Glargine-investigate-Diabetes Mellitus, Type 2', 'Exenatide-compare-Insulin Glargine', 'Colorectal Neoplasms-use-Neoplasms', 'Cetuximab-improve-Colorectal Neoplasms', 'Diabetes Mellitus, Type 2-treat-Exenatide', 'Diabetes Mellitus, Type 2-treat-Insulin Glargine', 'KRAS-receive-Cetuximab', 'KRAS-receive-Bevacizumab', 'Neoplasms-receive-Cetuximab', 'Neoplasms-receive-Bevacizumab', 'Nivolumab-show activity without-Drug-Related Side Effects and Adverse Reactions', 'Ipilimumab-show activity without-Drug-Related Side Effects and Adverse Reactions', 'APOE-study-Intellectual Disability', 'INS-naive-Diabetes Mellitus', 'Hyperglycemia-associated-Non-alcoholic Fatty Liver Disease', 'Non-alcoholic Fatty Liver Disease-associated-Hyperglycemia', 'Adenomatous Polyposis Coli-percentage of-Neoplasms', 'Non-alcoholic Fatty Liver Disease-rs1556516-CDKN2B-AS1', 'Fish Oils-improve-Cardiovascular Diseases', 'Fish Oils-improve-Kidney Diseases', 'Immunologic Deficiency Syndromes-studied-Kidney Diseases', 'Immunologic Deficiency Syndromes-studied-Doxorubicin', 'Vascular Calcification-scan-Iliac Aneurysm', 'Vascular Calcification-detect-Peripheral Arterial Disease', 'Peripheral Arterial Disease-brachial and ankle index-Hypertension', 'Peripheral Arterial Disease-telemetric assessment-Hypertension', 'Genetic Diseases, Inborn-defined-CFTR', 'Ataxia-occur-FMR1', 'Fondaparinux-associated-Hemorrhage', 'Hemorrhage-associated-Fondaparinux', 'Diabetes Mellitus, Type 2-compared-Insulin Resistance', 'Lung Diseases-be with-ALK', 'INS-compared-Insulin Resistance', 'Diabetes Mellitus-be with-Renal Insufficiency, Chronic', 'Diabetes Mellitus-enrolled-Glucose', 'Renal Insufficiency, Chronic-enrolled-Glucose', 'Renal Insufficiency, Chronic-control-Glucose', 'Diabetes Mellitus-enrolled-Cholesterol', 'Renal Insufficiency, Chronic-enrolled-Cholesterol', 'Renal Insufficiency, Chronic-control-Cholesterol', 'Acarbose-be in-Diabetes Mellitus', 'Breast Neoplasms-prevent-Neoplasm Metastasis', 'SLTM-prevent-Neoplasm Metastasis', 'Neoplasms-combined-Mesothelioma', 'Drug-Related Side Effects and Adverse Reactions-combined-Mesothelioma', 'Neoplasms-combined-Doxorubicin', 'Drug-Related Side Effects and Adverse Reactions-combined-Doxorubicin', 'Doxorubicin-be in-Mesothelioma', 'Doxorubicin-combined-Mesothelioma', 'Peripheral Nervous System Diseases-caused-Amyloidosis', 'Diabetes Mellitus-fail-INS', 'Obesity-fail-INS', 'Obesity-compare-INS', 'Diabetes Mellitus-provide-Glucose', 'Neoplasms-be at-Ventricular Dysfunction, Left', 'Anemia-provide-Glucose', 'Neoplasms-treated-Anthracyclines', 'Anthracyclines-treated-Ventricular Dysfunction, Left', 'Anthracyclines-treated-Heart Failure', 'Anthracyclines-treated-Death', 'Mastocytosis-activate-KIT', 'Leukemia, Myeloid-driven-KIT', 'Leukemia, Myeloid-activate-KIT', 'Mastocytosis-activate-rs121913507', 'Leukemia, Myeloid-activate-rs121913507', 'PTTG1IP-correlated-Neoplasm Metastasis', 'PTTG1IP-correlated-Neoplasms', 'Neoplasms-increased-Thyroid Neoplasms', 'Hypertension-induce-MAPT', 'PTTG1IP-increased-Thyroid Neoplasms', 'Neoplasms-associate-PTTG1IP', 'PTTG1IP-associate-Neoplasms', 'Neoplasms-found-PTTG1IP', 'MAPT-occur-Hypertension', 'Neoplasm Metastasis-include-Melanoma', 'Neoplasms-known-PTTG1IP', 'Obesity-randomized-Exenatide', 'Panitumumab-use-Pancreatic Neoplasms', 'Heart Arrest-down-regulate-Adenocarcinoma of Lung', 'Melanoma-develop-Neoplasm Metastasis', 'Ipilimumab-improve-Melanoma', 'Death-inhibit-Adenocarcinoma of Lung', 'Thrombosis-treatment of-Neoplasms', 'Ipilimumab-develop-Neoplasm Metastasis', 'Cardiovascular Diseases-give-Coronary Artery Disease', 'AKT1-be in-Adenocarcinoma of Lung', 'Cardiovascular Diseases-give-Death', 'Cardiovascular Diseases-give-Cholesterol', 'ADAM22-Bioinformatic analysis of-Breast Neoplasms', 'ADAM22-identify-Breast Neoplasms', 'ADAM22-identify-Neoplasm Metastasis', 'Fructosamine-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-Fructosamine', 'Neoplasms-treated-VEGFA', 'Sensation Disorders-couple-Diabetes Mellitus, Type 1', 'Heparin-be in-Critical Illness', 'Heparin-be in-Acute Kidney Injury', 'MATR3-produce-Abnormalities, Drug-Induced', 'MATR3-produce-Muscular Diseases', 'rs198389-be in-NPPB', 'MATR3-produce-Atrophy', 'NPPB-associated-Hypertension', 'Hypertension-associated-NPPB', 'NPPB-associated-Death', 'Death-associated-NPPB', 'Tauopathies-be in-Alzheimer Disease', 'rs198389-associated-Hypertension', 'Hypertension-associated-rs198389', 'BIN1-linked-Tauopathies', 'rs198389-associated-Death', 'Death-associated-rs198389', 'Renal Insufficiency, Chronic-compare-Kidney Diseases', 'Critical Illness-suffer-Acute Kidney Injury', 'Acute Kidney Injury-suffer-Heparin', 'INS-be with-Insulin Resistance', 'Diabetes Mellitus-controlled-Glucose', 'Diabetes Mellitus-treated-Insulin Resistance', 'Diabetes Mellitus, Type 1-achieve-Glucose', 'Non-alcoholic Fatty Liver Disease-be lead cause worldwide of-Liver Diseases', 'Fatty Liver-be lead cause worldwide of-Liver Diseases', 'Sensation Disorders-achieve-Glucose', 'Glucose-achieve-Hyperglycemia', 'INS-reduce complications In-Diabetes Mellitus', 'Peutz-Jeghers Syndrome-be with-Neoplasms', 'Peutz-Jeghers Syndrome-examined-STK11', 'Neoplasms-examined-STK11', 'HIV Infections-used-Infections', 'Acquired Immunodeficiency Syndrome-used-Infections', 'Insulin Resistance-initiate-Diabetes Mellitus', 'HIV Infections-used-CD4', 'Insulin Resistance-be effective than-Insulin Glargine', 'Acquired Immunodeficiency Syndrome-used-CD4', 'Insulin Glargine-be in-Diabetes Mellitus', 'Acromegaly-referred-Pituitary Diseases', 'Neoplasms-be with-Venous Thromboembolism', 'Neoplasms-prolong-Heparin, Low-Molecular-Weight', 'Epilepsies, Myoclonic-be with-Muscle Spasticity', 'von Willebrand Diseases-used-Aneurysm', 'Venous Thromboembolism-prolong-Heparin, Low-Molecular-Weight', 'ARX-cause-Epilepsies, Myoclonic', 'ARX-cause-Muscle Spasticity', 'ARX-cause-Intellectual Disability', 'Wiskott-Aldrich Syndrome-characterise-Neoplasms', 'ARX-cause-Ataxia', 'Genetic Diseases, X-Linked-caused-Wiskott-Aldrich Syndrome', 'Alzheimer Disease-mediated-Dementia', 'ARX-cause-Dystonia', 'Genetic Diseases, X-Linked-caused-Thrombocytopenia', 'Genetic Diseases, X-Linked-characterise-Thrombocytopenia', 'Genetic Diseases, X-Linked-characterise-Eczema', 'Genetic Diseases, X-Linked-characterise-Infections', 'APOB-account-Cholesterol', 'Nervous System Diseases-mediated-Dementia', 'Genetic Diseases, X-Linked-characterise-Neoplasms', 'APOB-increase-Heart Diseases', 'APOB-shorten-Stroke', 'APOB-increase-Diabetes Mellitus', 'Thrombocytopenia-characterise-Neoplasms', 'Heart Diseases-account-Cholesterol', 'Eczema-associated-Neoplasms', 'Neoplasms-associated-Eczema', 'Eczema-characterise-Neoplasms', 'APOE-mediated-Dementia', 'Stroke-account-Cholesterol', 'Pancreatic Neoplasms-display-Neoplasms', 'WAS-characterise-Neoplasms', 'KRAS-display-Neoplasms', 'Insulin Glargine-be in-INS', 'Insulin Glargine-protaminate-INS', 'INS-protaminate-Diabetes Mellitus', 'Wounds and Injuries-record-Coma', 'Wounds and Injuries-record-Brain Injuries, Traumatic', 'Death-reduce-Enalapril', 'CD4-linked-Acquired Immunodeficiency Syndrome', 'CD4-linked-Death', 'CBX7-act as-Carcinogenesis', 'CBX7-act-Stomach Neoplasms', 'CBX7-act as-Neoplasms', 'Mucopolysaccharidosis III-degrade-Glycosaminoglycans', 'Lysosomal Storage Diseases-degrade-Glycosaminoglycans', 'Huntington Disease-subjected-Hypoxia', 'Huntington Disease-subjected-Infliximab', 'Cystic Fibrosis-characterised-Respiratory Tract Infections', 'Cystic Fibrosis-characterised-Inflammation', 'Cystic Fibrosis-result-Inflammation', 'Breast Neoplasms-diagnosed-PGR', 'Cystic Fibrosis-characterised-Lung Diseases', 'Neoplasms-choose-Neoplasm Metastasis', 'CRP-predict-Neoplasm Metastasis', 'INS-perspective-Insulin Glargine', 'INS-use-Insulin Glargine', 'Respiratory Tract Infections-result-Inflammation', 'Cholesterol-reduce mortality in-Angina Pectoris', 'ACE-associate-Hypotension', 'Hypotension-associate-ACE', 'ACE-associate-Proteinuria', 'Proteinuria-associate-ACE', 'Obesity-develop-Diabetes Mellitus', 'Obesity-develop-Dyslipidemias', 'Obesity-develop-Gout', 'Hypoglycemia-improve-Diabetes Mellitus', 'Obesity-develop-Hypertension', 'Carcinoma, Hepatocellular-pertain-Hepatitis C', 'INS-improve quality in-Diabetes Mellitus', 'Carcinoma, Hepatocellular-pertain-Obesity', 'Obesity-develop-Cardiovascular Diseases', 'Carcinoma, Hepatocellular-pertain-Aflatoxins', 'CFTR-characterised-Respiratory Tract Infections', 'INS-majority of-Obesity', 'INS-develop-Obesity', 'CFTR-characterised-Lung Diseases', 'INS-majority-Gout', 'INS-majority-Hypertension', 'INS-majority-Cardiovascular Diseases', 'Ovarian Diseases-be in-Breast Neoplasms', 'AMH-support toxicity In-Breast Neoplasms', 'Anemia, Sickle Cell-decrease-Proteinuria', 'AMH-support-Ovarian Diseases', 'ACE-assess-Proteinuria', 'ACE-reduce-Anemia, Sickle Cell', 'Prostatic Neoplasms-Screening with-KLK3', 'Prostatic Neoplasms-reduce-KLK3', 'Spasms, Infantile-present with-Heart Arrest', 'Death-Screening with-KLK3', 'Death-reduce-KLK3', 'Anemia-be in-Lung Neoplasms', 'Anemia-paralleled-Ceramides', 'Lung Neoplasms-triggered-Ceramides', 'Hemorrhage-receive-Nadroparin', 'Fibrosis-related-Death', 'Protein S Deficiency-be autosomal recessive inborn error of-Fatty Acids', 'Anemia-caused-Kidney Failure, Chronic', 'EPO-caused-Kidney Failure, Chronic', 'Li-Fraumeni Syndrome-caused-TP53', 'TP53-caused-Neoplasms', 'HIV Infections-treat-CD4', 'CD4-treat-Acquired Immunodeficiency Syndrome', 'Leukemia, Myeloid, Acute-characterized-Leukemia, Promyelocytic, Acute', 'Diabetes Mellitus, Type 2-stratified-Hypoglycemia', 'Diabetes Mellitus-make-Dyskinesias', 'Diabetes Mellitus-make-INS', 'Diabetes Mellitus-stratified-Hypoglycemia', 'HEXA-developed-Tay-Sachs Disease', 'HEXA-caused-Gangliosidoses', 'Prostatic Neoplasms-identify-Prostatitis', 'Prostatic Neoplasms-associated-Prostatitis', 'Prostatitis-associated-Prostatic Neoplasms', 'von Willebrand Diseases-predict-Hypertension, Pulmonary', 'Prostatic Neoplasms-identify-KLK3', 'Kidney Failure, Chronic-present-Fever', 'KLK3-identify-Prostatitis', 'KLK3-associated-Prostatitis', 'Prostatitis-associated-KLK3', 'Kidney Failure, Chronic-accompanied-Pain', 'Glomerulonephritis-present-Fever', 'Glomerulonephritis-accompanied-Pain', 'Fever-accompanied-Pain', 'TP53-enrolled-Neoplasms', 'TP53-enrolled-Li-Fraumeni Syndrome', 'Mycophenolic Acid-present-Fever', 'Mycophenolic Acid-accompanied-Pain', 'Cyclosporine-present-Fever', 'Bevacizumab-approved-Lung Neoplasms', 'Cyclosporine-accompanied-Pain', 'Bevacizumab-approved-Carcinoma, Squamous Cell', 'Breast Neoplasms-evaluate-Neoplasms', 'HIV Infections-followed-Communicable Diseases', 'HIV Infections-provided-Communicable Diseases', 'KLK3-included-HIV Infections', 'KLK3-provided-HIV Infections', 'TMEM37-evaluate-Neoplasms', 'KLK3-included-Communicable Diseases', 'Cardiomyopathies-be major cause of-Death', 'INS-contribute-Cystic Fibrosis', 'Cardiovascular Diseases-calculated-Diabetes Mellitus', 'Cardiovascular Diseases-calculated-Hypertension', 'Cardiovascular Diseases-calculated-Cholesterol', 'Diabetes Mellitus, Type 2-reduce-Hypoglycemia', 'Diabetes Mellitus, Type 2-lower-Hypotension', 'Hypoglycemia-reduce-Hypotension', 'Diabetes Mellitus, Type 2-lower-Glucose', 'Insulin Glargine-switching-INS', 'Opportunistic Infections-reduce-Death', 'GLP1R-reduce-Cardiovascular Diseases', 'Cholesterol-elevate-Epilepsy, Benign Neonatal', 'CD4-reduce-Opportunistic Infections', 'CTLA4-provide-Mesothelioma', 'CTLA4-provide-Melanoma', 'Inflammation-develop-Long QT Syndrome', 'Nervous System Diseases-develop-Long QT Syndrome', 'Genetic Diseases, Inborn-associated-Emphysema', 'Emphysema-associated-Genetic Diseases, Inborn', 'Genetic Diseases, Inborn-associated-Liver Cirrhosis', 'Liver Cirrhosis-associated-Genetic Diseases, Inborn', 'CD4-develop-Long QT Syndrome', 'Genetic Diseases, Inborn-associated-Carcinoma, Hepatocellular', 'Carcinoma, Hepatocellular-associated-Genetic Diseases, Inborn', 'Neoplasms-compare-Trastuzumab', 'Breast Neoplasms-compare-Trastuzumab', 'Nocardia Infections-caused-HIV Infections', 'HIV Infections-treated-Uterine Cervicitis', 'Nocardia Infections-treated-Amikacin', 'Death-be common during-Rituximab', 'Uterine Cervicitis-treated-Amikacin', 'Cardiotoxicity-investigated-Breast Neoplasms', 'Anthracyclines-investigated-Breast Neoplasms', 'Anthracyclines-induced-Breast Neoplasms', 'Inflammation-monitored-HIV Infections', 'PHB1-analyzed-Pancreatic Neoplasms', 'CRP-monitored-HIV Infections', 'Urinary Bladder Neoplasms-establish-Drug-Related Side Effects and Adverse Reactions', 'PHB1-analyzed-Carcinoma, Pancreatic Ductal', 'Urinary Bladder Neoplasms-establish-TNF', 'CD4-accumulate-Synovial Cyst', 'CD4-found-Synovial Cyst', 'LRRK2-manifest-Parkinson Disease', 'Venous Thrombosis-follow-Pulmonary Embolism', 'Venous Thrombosis-follow-Thrombocytopenia', 'Venous Thrombosis-follow-Hemorrhage', 'Pulmonary Embolism-follow-Thrombocytopenia', 'Diabetes Mellitus-characterised-Insulin Resistance', 'Pulmonary Embolism-follow-Hemorrhage', 'Thrombocytopenia-follow-Hemorrhage', 'Diabetes Mellitus-characterised-INS', 'Neoplasms-display-Microsatellite Instability', 'Fluvastatin-reduce-Angina, Unstable', 'Fluvastatin-reduce-Ischemia', 'MEN1-be autosomal dominant disorder due-Neoplasms', 'Neoplasms-encode-MEN1', 'MB-be in-Critical Illness', 'Insulin Glargine-compare-INS', 'Fabry Disease-caused-GLA', 'Lysosomal Storage Diseases-caused-GLA', 'Heparin, Low-Molecular-Weight-treat-Venous Thromboembolism', 'Heparin-recommended-Neoplasms', 'Neoplasms-treated-Heparin, Low-Molecular-Weight', 'Prostatic Diseases-include-Prostatic Neoplasms', 'Prostatic Diseases-diagnosed-Prostatic Neoplasms', 'Venous Thrombosis-use-Heparin', 'Pulmonary Embolism-use-Heparin', 'Atorvastatin-associated-Myocardial Infarction', 'Myocardial Infarction-associated-Atorvastatin', 'Atorvastatin-associated-Coronary Artery Disease', 'Coronary Artery Disease-associated-Atorvastatin', 'Critical Illness-assign-Enoxaparin', 'Venous Thromboembolism-be with-Enoxaparin', 'Death-associated-ATM', 'ATM-associated-Death', 'Ventricular Dysfunction, Left-reduce-Enalapril', 'Enalapril-be in-Ventricular Dysfunction, Left', 'Enalapril-reduce-Ventricular Dysfunction, Left', 'ACE-titrate-Heart Failure', 'Brain Neoplasms-imply-Glioma', 'ACE-titrate-Stroke', 'Genetic Diseases, Inborn-be with-Paralysis', 'Genetic Diseases, Inborn-caused-PMP22', 'Paralysis-caused-PMP22', 'Neuromuscular Diseases-caused-PMP22', 'Triglycerides-associated-Calcinosis', 'Calcinosis-associated-Triglycerides', 'Diabetes Mellitus-test-Death', 'Neoplasms-carry-Glioma', 'Diabetes Mellitus-decrease-Myocardial Infarction', 'Neoplasms-be in-NF1', 'Myocardial Infarction-be in-Diabetes Mellitus', 'NF1-carry-Glioma', 'Atorvastatin-decrease-Death', 'Atorvastatin-rate of-Death', 'NF1-carry-Neoplasms', 'Atorvastatin-decrease-Myocardial Infarction', 'Atorvastatin-rate of-Myocardial Infarction', 'Glucose Metabolism Disorders-report-Death', 'Atorvastatin-decrease-Diabetes Mellitus', 'Atorvastatin-rate of-Diabetes Mellitus', 'rs2132039-associated-Carcinoma, Hepatocellular', 'Carcinoma, Hepatocellular-associated-rs2132039', 'UGT2B28-be indicative of-Carcinoma, Hepatocellular', 'Vascular Calcification-correlate-Heart Failure', 'Heart Failure-correlate-TNFRSF11B', 'TNFRSF11B-correlate-Heart Failure', 'Anemia-be common feature during-Sepsis', 'Calcifediol-correlate-Heart Failure', 'Sepsis-occur-Postpartum Hemorrhage', 'Sepsis-occur-EPO', 'KLK3-result-Death', 'KLK3-result-Prostatic Neoplasms', 'Cardiovascular Diseases-subdivided-Glucose', 'Fibrosis-subdivided-Glucose', 'Neoplasms-be in-Lung Neoplasms', 'Neoplasms-be in-ALK', 'Neoplasms-examine-Anemia, Hypochromic', 'ALK-show-Lung Neoplasms', 'APOE-be important genetic marker for-Alzheimer Disease', 'EPO-examine-Anemia, Hypochromic', 'Respiratory Tract Infections-nebulise-Tobramycin', 'Cystic Fibrosis-nebulise-Tobramycin', 'Muscular Dystrophy, Duchenne-be result of-DMD', 'Neoplasms-be with-Lymphopenia', 'Neoplasms-be with-CD4', 'Cystic Fibrosis-correlate-Inflammation', 'Cystic Fibrosis-correlate-Phosphatidylcholines', 'Acromegaly-operated-Pituitary Neoplasms', 'IGF1-operated-Pituitary Neoplasms', 'Glucose-explain-Cardiovascular Diseases', 'ERBB2-be actionable target in-Neoplasms', 'Eptifibatide-reduce-Death', 'Eptifibatide-reduce-Myocardial Infarction', 'Eptifibatide-reduce relative in-Acute Coronary Syndrome', 'Eptifibatide-reduce-Angina, Unstable', 'Precursor Cell Lymphoblastic Leukemia-Lymphoma-receive-Doxorubicin', 'Neoplasms-receive-Doxorubicin', 'Alzheimer Disease-manage-Dementia', 'Neurodegenerative Diseases-include-Leigh Disease', 'APOE-manage-Dementia', 'Respiratory Tract Infections-be in-Cystic Fibrosis', 'GH1-reduce-Obesity', 'GH1-reduce-Atherosclerosis', 'Death-reviewed-APOE', 'Alzheimer Disease-reviewed-APOE', 'Fabry Disease-lead-Glycosphingolipids', 'Death-be in-Renal Insufficiency, Chronic', 'Dysautonomia, Familial-lead-Glycosphingolipids', 'FGF23-associated-Hypertrophy, Left Ventricular', 'Hypertrophy, Left Ventricular-associated-FGF23', 'Genetic Diseases, Inborn-lead to-Glycosphingolipids', 'HIV Infections-acquire-Acquired Immunodeficiency Syndrome', 'HIV Infections-affected-Retinitis', 'Acquired Immunodeficiency Syndrome-acquire-Retinitis', 'Diabetes Mellitus-include-Dyslipidemias', 'Acquired Immunodeficiency Syndrome-acquire-CD4', 'Peutz-Jeghers Syndrome-characterized-Intestinal Polyposis', 'Diabetes Mellitus-reduce-Hyperglycemia', 'Peutz-Jeghers Syndrome-characterized-Pigmentation Disorders', 'CD4-with those be-Retinitis', 'Peutz-Jeghers Syndrome-characterized-Neoplasms', 'INS-increase-Diabetes Mellitus, Type 1', 'Dyslipidemias-reduce-Hyperglycemia', 'Nucleosides-demonstrate-Leukemia', 'Nucleosides-demonstrate-Neoplasms', 'Dyslipidemias-reduce-Cardiovascular Diseases', 'Peutz-Jeghers Syndrome-characterized-STK11', 'BRCA2-be at-Neoplasms', 'Inflammation-reduce-Hyperglycemia', 'BRCA2-be at-Adenocarcinoma', 'Inflammation-reduce-Cardiovascular Diseases', 'Cardiovascular Diseases-screened-Atherosclerosis', 'Adenocarcinoma-extend-Death', 'Adenocarcinoma-extend-BRCA2', 'Atherosclerosis-screened-Myocardial Infarction', 'Death-include-BRCA2', 'INS-include-Atherosclerosis', 'SIRT6-interact with-MUTYH', 'ELN-augment-NOS3', 'BCL2-over-express-TP53', 'TNFRSF11B-correlate-CEACAM3', 'GRB2-be in-ERBB2', 'INS-downregulate-SHBG', 'PKD1-compared-PKD2', 'SHBG-correlate-INS', 'CRP-administered-GGH', 'CRP-reduce-GGH', 'LDLR-include-APOB', 'LDLR-decrease-APOB', 'Maltose-be In-Icodextrin', 'Fatty Acids, Omega-3-contain-Eicosapentaenoic Acid', 'Fatty Acids, Omega-3-contain-Docosahexaenoic Acids', 'Cholesterol-assigned-Fluvastatin', 'Cholesterol-increase-Triglycerides', 'Fractures, Bone-challenge-Death', 'Death-attributed-Parasitic Diseases', 'Wounds and Injuries-admitted-Brain Injuries, Traumatic', 'Stroke-be lead cause of-Death', 'Weight Gain-Patients with-Craniopharyngioma', 'Weight Gain-experience-Craniopharyngioma', 'Craniopharyngioma-experience-Obesity', 'Craniopharyngioma-experience-Glucose Metabolism Disorders', 'Craniopharyngioma-experience-Death', 'Shock, Septic-associated-Pneumonia', 'Pneumonia-associated-Shock, Septic', 'Osteoporotic Fractures-present-Wounds and Injuries', 'Abnormalities, Drug-Induced-placed-Thoracic Diseases', 'Osteoporotic Fractures-present-Fractures, Compression', 'Hypertension-be with-Aneurysm', 'Hepatitis B, Chronic-remain-Carcinoma, Hepatocellular', 'Atrial Fibrillation-assess-Embolism', 'Hepatitis B, Chronic-remain-Fibrosis', 'Heterotaxy Syndrome-be non-inferior for-Stroke', 'Death-be in-Aneurysm', 'Atrial Fibrillation-compare-Heterotaxy Syndrome', 'Atrial Fibrillation-compare-Thromboembolism', 'Atrial Fibrillation-be with-Thromboembolism', 'Heterotaxy Syndrome-compare-Stroke', 'Diabetes Mellitus-admitted-Ischemia', 'Heterotaxy Syndrome-compare-Thromboembolism', 'Neoplasms-near-Death', 'Anemia, Sickle Cell-cause-Neurologic Manifestations', 'Neoplasms-related-Fatigue', 'Neoplasms-talking-Fatigue', 'Genetic Diseases, Inborn-cause-Neurologic Manifestations', 'Neurologic Manifestations-cause-Communicable Diseases', 'Neoplasms-persist-Memory Disorders', 'Fatigue-persist-Memory Disorders', 'Obesity-have surgery costs Among-Spinal Diseases', 'Phenylketonurias-derived-Pituitary Neoplasms', 'Malocclusion-derived-HIV Infections', 'Malocclusion-live-HIV Infections', 'Anemia-be relevant comorbidities with-Death', 'Hypertension-be relevant comorbidities with-Death', 'Adenomatous Polyposis Coli-increase-Colorectal Neoplasms', 'Genetic Diseases, Inborn-increase-Colorectal Neoplasms', 'Parkinson Disease, Secondary-follow by-Dementia', 'Gastric Outlet Obstruction-be clinical and pathological consequence of-Neoplasms', "Death-identify-Legionnaires' Disease", 'Heart Diseases-document-Death', 'Genetic Diseases, Inborn-characterized-Anemia', 'Death-be common in-Heart Diseases', 'Genetic Diseases, Inborn-associated-Nervous System Diseases', 'Nervous System Diseases-associated-Genetic Diseases, Inborn', 'Anemia-associated-Nervous System Diseases', 'Nervous System Diseases-associated-Anemia', 'Muscular Dystrophy, Duchenne-slow-Muscle Weakness', 'Osteoporosis-prevent-Congenital Hypothyroidism', 'Coronary Artery Disease-lead cause worldwide of-Death', 'Death-seem-Stroke', 'Inflammatory Bowel Diseases-result-Genetic Diseases, Inborn', 'Cardiovascular Diseases-prevent-Colorectal Neoplasms', 'Encephalitis, California-diagnosed-Thyroid Cancer, Papillary', 'Drug Hypersensitivity-be with-Neoplasms', 'Edema-characterized-Angioedemas, Hereditary', 'Nervous System Diseases-cause-Inflammatory Bowel Diseases', 'Nervous System Diseases-suffer-Inflammatory Bowel Diseases', 'Lysosomal Storage Diseases-result-Heart Diseases', 'Death-classified-Obesity', 'Polycystic Ovary Syndrome-diagnosed-Hyperandrogenism', 'Death-encounter-Stroke', 'Stroke-guide-Atrial Fibrillation', 'Hemorrhage-compare-Atrial Fibrillation', 'Atrial Fibrillation-balanced-Stroke', 'Atrial Fibrillation-balanced-Hemorrhage', 'Heart Failure-Mellitus of-Stroke', 'Stroke-must-Hemorrhage', 'Stroke-balanced-Hemorrhage', 'Heart Failure-simulated-Atrial Fibrillation', 'Hypertension-simulated-Atrial Fibrillation', 'Diabetes Mellitus-simulated-Atrial Fibrillation', 'Nephritis-cause-Renal Insufficiency', 'Nephritis-reduce-Lupus Erythematosus, Systemic', 'Stroke-simulated-Atrial Fibrillation', 'Headache-improve-Ophthalmoplegia', 'Cystic Fibrosis-result-Respiratory Insufficiency', 'Genetic Diseases, Inborn-result-Respiratory Insufficiency', 'Diabetes Mellitus, Type 2-used-Insulin Resistance', 'Diabetes Mellitus, Type 2-treated-Insulin Resistance', 'Insulin Resistance-associated-Hypoglycemia', 'Hypoglycemia-associated-Insulin Resistance', 'Neurologic Manifestations-increase-Critical Illness', 'Thrombosis-increase-Critical Illness', 'Thoracic Diseases-cause-Nervous System Diseases', 'Carcinoma, Hepatocellular-immune tolerant patients-Fibrosis', 'Bone Diseases-be common cause of-Neoplasms', 'Leukemia, Myelogenous, Chronic, BCR-ABL Positive-represent-Leukemia', 'Neoplasms-represent-Leukemia', 'Thoracic Diseases-undergo-Neoplasms', 'Diabetes Mellitus-search details for-Lung Neoplasms', 'Diabetes Mellitus-identified-Lung Neoplasms', 'Hypertension-reduce-Kidney Failure, Chronic', 'Diabetes Mellitus-reduce-Kidney Failure, Chronic', 'Cardiovascular Diseases-worsen-Angina Pectoris', 'Cardiovascular Diseases-worsen-Diabetes Mellitus', 'Death-incidence of-Cardiovascular Diseases', 'Death-worsen-Angina Pectoris', 'Death-worsen-Diabetes Mellitus', 'Breast Neoplasms-remain-Chronic Disease', 'Breast Neoplasms-reduce-Endometrial Neoplasms', 'Breast Neoplasms-offset-Endometrial Neoplasms', 'Breast Neoplasms-reduce-Pulmonary Embolism', 'Breast Neoplasms-offset-Pulmonary Embolism', 'Neoplasms-be second common cause of-Death', 'Death-suffer-Spinal Cord Injuries', 'Death-suffer from-Spinal Cord Injuries', 'Prader-Willi Syndrome-cause-Obesity', 'Prader-Willi Syndrome-lead-Death', 'Intellectual Disability-cause-Obesity', 'Intellectual Disability-lead-Death', 'Hyperphagia-cause-Obesity', 'Hyperphagia-lead-Death', 'Diabetes Mellitus, Type 2-suspected-Osteomyelitis', 'Wolff-Parkinson-White Syndrome-survive-Heart Arrest', 'Fractures, Bone-occur-Neoplasm Metastasis', 'Infections-increase-Sepsis', 'Breast Neoplasms-obtained-Death', 'Glomerulonephritis-be in-Kidney Diseases', 'Pregnancy Complications, Infectious-increased-Colitis, Ulcerative', 'Death-increased-Colitis, Ulcerative', 'Joint Diseases-noticed-Thalassemia', 'Stillbirth-capture-Death', 'Death-follow-Chronic Disease', 'Cardiovascular Diseases-be lead cause of-Death', 'HIV Infections-measure-Muscular Dystrophy, Duchenne', 'HIV Infections-be independent predictors of-Muscular Dystrophy, Duchenne', 'Neoplasms-considered-Neoplasm Metastasis', 'Death-prevent-Lung Neoplasms', 'Dementia-hospitalized-Hip Fractures', 'Hodgkin Disease-involve-Neoplasms', 'Neoplasm Metastasis-be with-Neoplasms', 'Cardiomyopathies-be important predictor in-Hemochromatosis', 'Death-do-Renal Insufficiency', 'Renal Insufficiency, Chronic-do-Renal Insufficiency', 'Infections-be with-HIV Infections', 'Crohn Disease-find-Inflammation', 'Wounds and Injuries-exposed-Compassion Fatigue', 'Death-discriminate-Colorectal Neoplasms', 'Colorectal Neoplasms-preclude-Death', 'Death-preclude-Neoplasms', 'Death-reduce-Carcinogenesis', 'Carcinoma, Hepatocellular-reduce-Carcinogenesis', 'Neoplasms-be significant independent predictor of-Death', 'Hodgkin Disease-mSv in-Lymphoma, Non-Hodgkin', 'Hodgkin Disease-mSv in-Neuroblastoma', 'Lymphoma, Non-Hodgkin-mSv in-Neuroblastoma', 'Neuroblastoma-mSv in-Neoplasms', 'Neuroblastoma-mSv in-Brain Neoplasms', 'Neoplasms-metastasize-Multiple Myeloma', 'Neoplasms-result-Fractures, Bone', 'Multiple Myeloma-result-Fractures, Bone', 'Fractures, Compression-related-Neoplasms', 'Neoplasms-be with-Fractures, Compression', 'Vascular Calcification-identify-Iliac Aneurysm', 'Vascular Calcification-use-Cardiovascular Diseases', 'Iliac Aneurysm-identify-Cardiovascular Diseases', 'Skin Diseases, Papulosquamous-followed-Tuberculosis, Cutaneous', 'Pancreatic Neoplasms-induce-Death', 'Autoimmune Diseases-be with-Chronic Disease', 'Astrocytoma-provide-Neoplasms', 'Diabetes Mellitus-be with-Ischemia', 'Dyskinesias-improve outcomes in-Thalassemia', 'Deglutition Disorders-caused-Esophageal Diseases', 'Breast Neoplasms-receive-Cardiotoxicity', 'Neoplasms-receive-Cardiotoxicity', 'Aneurysm-study-Intracranial Aneurysm', 'Inflammation-contained-Infections', 'Inflammation-considered-Urinary Bladder Neoplasms', 'Infections-considered-Urinary Bladder Neoplasms', 'Schistosomiasis-considered-Urinary Bladder Neoplasms', 'Substance-Related Disorders-considered-Urinary Bladder Neoplasms', 'Chronic Disease-be lead cause of-Death', 'Neoplasms-be translate into-Neoplasm Metastasis', 'Retinoblastoma-treat-Hearing Loss', 'Retinoblastoma-used-Hearing Loss', 'Korsakoff Syndrome-emerge-Wernicke Encephalopathy', 'Memory Disorders-emerge-Wernicke Encephalopathy', 'Acute Coronary Syndrome-demonstrated-Angina Pectoris', 'Melanoma-involve-Ocular Hypertension', 'Prostatic Neoplasms-use-Neoplasms', 'Cardiovascular Diseases-lead cause of-Death', 'Cardiovascular Diseases-droppe-Death', 'Rupture-base-Aneurysm', 'Aneurysm-profound impact on-Rupture', 'Death-need in-Prostatic Neoplasms', 'Death-investigate-Prostatic Neoplasms', 'Prostatic Neoplasms-be progressive disease with-Death', 'Death-be similar without-Breast Neoplasms', 'Cystic Fibrosis-associated-Infections', 'Infections-associated-Cystic Fibrosis', 'Immunologic Deficiency Syndromes-develop-Pneumonia, Pneumocystis', 'Osteoporosis-related-Hip Fractures', 'Cardiovascular Diseases-related-Neoplasms', 'Neoplasms-make-Cardiovascular Diseases', 'Cardiovascular Diseases-make-Neoplasms', 'Prostatic Neoplasms-be important cause worldwide of-Death', 'Prostatic Neoplasms-make-Cardiovascular Diseases', 'Prostatic Neoplasms-make-Neoplasms', 'Cardiovascular Diseases-frequent and important co-morbidity in-Neoplasms', 'Cardiovascular Diseases-be in-Neoplasms', 'Neoplasms-improve-Glioma', 'Skin Neoplasms-followed-Neoplasms', 'Arthrogryposis-characterized-Contracture', 'Death-base-Prostatic Neoplasms', 'Neoplasms-receive-Neoplasm Metastasis', 'Inflammation-be in-Nervous System Diseases', 'Neoplasms-scheduled-Fractures, Bone', 'Prostatic Neoplasms-time-Death', 'Prostatic Neoplasms-men-Death', 'Drug-Related Side Effects and Adverse Reactions-achieve-Necrosis', 'Drug-Related Side Effects and Adverse Reactions-debulk-Pain', 'Drug-Related Side Effects and Adverse Reactions-prevent-Fractures, Bone', 'Drug-Related Side Effects and Adverse Reactions-prevent-Osteolysis', 'Necrosis-associated-Pain', 'Pain-associated-Necrosis', 'Necrosis-prevent-Fractures, Bone', 'Necrosis-achieve-Osteolysis', 'Pain-prevent-Osteolysis', 'Fractures, Bone-prevent-Osteolysis', 'Headache-be in-Lung Diseases', 'HIV Infections-cause-Death', 'Neoplasm Metastasis-diagnosed-Hypertension', 'Death-registered-Stroke', 'Stroke-registered-Death', 'Neoplasms-be lead cause of-Death', 'Metabolic Syndrome-treat-Weight Loss', 'Diabetes Mellitus, Type 2-estimated-Diabetes Mellitus', 'Carcinoma, Hepatocellular-identified-Neoplasms', 'Cystic Fibrosis-expected-Fatigue', 'Telangiectasia, Hereditary Hemorrhagic-caused-Arteriovenous Malformations', 'Stroke-recommended-Telangiectasia, Hereditary Hemorrhagic', 'Stroke-caused-Arteriovenous Malformations', 'Brain Abscess-recommended-Telangiectasia, Hereditary Hemorrhagic', 'Intracranial Hemorrhages-recommended-Telangiectasia, Hereditary Hemorrhagic', 'Brain Abscess-caused-Arteriovenous Malformations', 'Cystic Fibrosis-predicted-Ossification of Posterior Longitudinal Ligament', 'Lupus Erythematosus, Systemic-confined-Nephritis', 'Cancer Pain-cause-Seizures', 'Neoplasms-cause-Seizures', 'Crohn Disease-face-Pneumonia', 'Stroke-caused-Carotid Stenosis', 'Pneumonia, Pneumocystis-occurring-Crohn Disease', 'Neoplasm Metastasis-observed-Neoplasms', 'Ocular Hypertension-observed-Neoplasms', 'Dwarfism, Pituitary-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-Dwarfism, Pituitary', 'Neoplasm Metastasis-occur-Breast Neoplasms', 'Neoplasm Metastasis-reported-Neoplasms', 'Anemia, Sickle Cell-performed-Graft vs Host Disease', 'Pre-Eclampsia-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-Pre-Eclampsia', 'Neoplasm Metastasis-do-Neoplasms', 'Heart Failure-evaluate-Viremia', 'Arbovirus Infections-lead-Immunologic Deficiency Syndromes', 'Pain-caused-Neoplasm Metastasis', 'Pain-prevent-Neoplasm Metastasis', 'Neoplasm Metastasis-achieve-Pain', 'Death-identify-Parkinson Disease', 'Dementia-predict-Psychoses, Substance-Induced', 'Psychoses, Substance-Induced-predict-Death', 'Psychoses, Substance-Induced-predict-Parkinson Disease', 'Leukemia, Myelogenous, Chronic, BCR-ABL Positive-treated-Neoplasms', 'Death-be in-Dementia', 'Kidney Diseases-Studies-Death', 'Kidney Diseases-differ-Death', 'Leukemia, Myeloid, Acute-experience-Neutropenia', 'Leukemia, Myeloid, Acute-lead-Invasive Fungal Infections', 'Myelodysplastic Syndromes-experience-Neutropenia', 'Neutropenia-lead to-Invasive Fungal Infections', 'Neutropenia-experience-Invasive Fungal Infections', 'Acromegaly-consist-Heart Valve Diseases', 'Renal Insufficiency, Chronic-be with-Diabetes Mellitus', 'Hypertension-compared-Diabetes Mellitus', 'Adenomatous Polyposis Coli-prevent-Death', 'Adenomatous Polyposis Coli-prevent-Colorectal Neoplasms', 'Death-prevent-Colorectal Neoplasms', 'Cardiovascular Diseases-treat-Hyperlipidemias', 'Hypertension-treat-Hyperlipidemias', 'Alprostadil-combined-Heparin', 'Retinal Diseases-predicted-Diabetes Mellitus, Type 2', 'Hyperlipidemias-treat-Death', 'Retinal Diseases-develop-Blindness', 'Edema-predicted-Diabetes Mellitus, Type 2', 'Edema-develop-Blindness', 'Diabetes Mellitus, Type 2-develop-Blindness', 'Peri-Implantitis-complicated-Infections', 'Glucose Metabolism Disorders-be in-Cystic Fibrosis', 'Obesity-consider-Weight Loss', 'Cardiovascular Diseases-extracted-Death', 'Diabetes Mellitus-promote-Thinness', 'Liver Failure-caused-Alcoholism', 'Multiple Pulmonary Nodules-associated-Neoplasms', 'Neoplasms-associated-Multiple Pulmonary Nodules', 'Cerebral Infarction-included-Stroke', 'Death-be common after-Stroke', 'HIV Infections-present-Neoplasms', 'Anemia, Sickle Cell-consult-Dyspnea', 'Myositis Ossificans-diagnosed-Abnormalities, Drug-Induced', 'Myositis Ossificans-characterized-Musculoskeletal Abnormalities', 'Genetic Diseases, Inborn-characterized-Musculoskeletal Abnormalities', 'Death-be elevated among-Diabetes Mellitus', 'Death-Patients with-Diabetes Mellitus', 'Neoplasms-suffer-Pelvic Pain', 'Death-be with-Aneurysm', 'Thyroid Carcinoma, Anaplastic-remain-Neoplasms', 'Thyroid Cancer, Papillary-contain-Thyroid Carcinoma, Anaplastic', 'Mobility Limitation-be with-Muscular Dystrophy, Duchenne', 'Mobility Limitation-reduce-Scoliosis', 'Muscular Dystrophy, Duchenne-reduce-Scoliosis', 'Cholangitis, Sclerosing-associated-Inflammatory Bowel Diseases', 'Inflammatory Bowel Diseases-associated-Cholangitis, Sclerosing', 'Alcoholism-be with-Death', 'Low Back Pain-caused-Intervertebral Disc Degeneration', 'Renal Insufficiency, Chronic-be lead cause of-Death', 'Anemia-be common among-Stomach Neoplasms', 'Cardiomyopathy, Hypertrophic-determine-Cardiovascular Diseases', 'Death-identified-Cardiomyopathy, Hypertrophic', 'Death-patients with-Neoplasms', 'Head and Neck Neoplasms-censored-Death', 'Neoplasms-censored-Death', 'Neoplasms-undergo-Lung Neoplasms', 'Neoplasms-referred-Lung Neoplasms', 'Telangiectasia, Hereditary Hemorrhagic-associated-Arteriovenous Malformations', 'Arteriovenous Malformations-associated-Telangiectasia, Hereditary Hemorrhagic', 'Telangiectasia, Hereditary Hemorrhagic-associated-Telangiectasis', 'Telangiectasis-associated-Telangiectasia, Hereditary Hemorrhagic', 'Genetic Diseases, Inborn-associated-Arteriovenous Malformations', 'Arteriovenous Malformations-associated-Genetic Diseases, Inborn', 'Genetic Diseases, Inborn-associated-Telangiectasis', 'Telangiectasis-associated-Genetic Diseases, Inborn', 'Thalassemia-considered-Anemia', 'Coronary Artery Disease-influence-Death', 'Carotid Stenosis-included-Aortic Aneurysm, Abdominal', 'Peripheral Arterial Disease-included-Aortic Aneurysm, Abdominal', 'Heart Failure-reduce-Neoplasms', 'Aneurysm-offer-Death', 'Neoplasms-be comparable across-Kidney Diseases', 'Urethral Neoplasms-gained-Neoplasms', 'Angioedemas, Hereditary-characterized-Skin Diseases', 'Angioedemas, Hereditary-characterized-Abdominal Pain', 'Kidney Diseases-be in-Cystic Fibrosis', 'Gastric Outlet Obstruction-complicate-Neoplasms', 'Neoplasms-include-Thyroid Neoplasms', 'Thyroid Neoplasms-tumors-Meningeal Neoplasms', 'Thyroid Neoplasms-tumors-Glioma', 'Neoplasms-live-Death', 'Diabetes Mellitus-live-Death', 'Heart Diseases-live-Death', 'Stroke-live-Death', 'Chronic Disease-associated-Colorectal Neoplasms', 'Colorectal Neoplasms-associated-Chronic Disease', 'Neoplasms-vary-Chronic Disease', 'Neoplasms-treated-Chemical and Drug Induced Liver Injury', 'Constriction, Pathologic-associated-Obesity', 'Obesity-associated-Constriction, Pathologic', 'Intermittent Claudication-caused-Iliac Aneurysm', 'Thalassemia-predict-Myelodysplastic Syndromes', 'Death-be with-Infections', 'Sarcoidosis, Pulmonary-cause-End Stage Liver Disease', 'End Stage Liver Disease-continue-Death', 'Fatty Liver-increase-Death', 'Intracranial Aneurysm-represent-Death', 'Headache-observed-Epilepsy, Tonic-Clonic', 'Neurologic Manifestations-rescue-Memory Disorders', 'Neoplasms-encompass-Dysplastic Nevus Syndrome', 'Myotonic Dystrophy-equal-Diabetes Mellitus', 'Cerebral Palsy-registered-Abnormalities, Drug-Induced', 'Cerebral Palsy-linked-Death', 'Adenocarcinoma-combined-Neoplasm Metastasis', 'Cardiovascular Diseases-estimated-Diabetes Mellitus, Type 2', 'Genetic Diseases, Inborn-characterized-Ossification, Heterotopic', 'Genetic Diseases, Inborn-characterized-Edema', 'Tuberculosis-made-HIV Infections', 'Diabetes Mellitus-consist-Diabetes Mellitus, Type 2', 'Diabetes Mellitus-registered-Diabetes Mellitus, Type 2', 'Inflammation-related-Multiple Sclerosis', 'Neurodegenerative Diseases-related-Multiple Sclerosis', 'HIV Infections-associated-Periodontitis', 'Periodontitis-associated-HIV Infections', 'Carcinoma, Hepatocellular-recruited-Neoplasms', 'Pain-changes in-Neoplasms', 'Kidney Failure, Chronic-associated-Kidney Diseases', 'Kidney Diseases-associated-Kidney Failure, Chronic', 'Heart Diseases-document-Death, Sudden, Cardiac', 'Heart Diseases-remain at-Death, Sudden, Cardiac', 'Budd-Chiari Syndrome-be result of-Thrombosis', 'Pulmonary Disease, Chronic Obstructive-be with-Asthma', 'Dementia-met-Cerebrovascular Disorders', 'Hypercalcemia-be fatal paraneoplastic complication of-Neoplasms', 'Alzheimer Disease-be with-Cerebrovascular Disorders', 'Machado-Joseph Disease-admitted-Neoplasms', 'Hepatitis C-lead-Death', 'Liver Diseases-lead-Death', 'Chronic Kidney Disease-Mineral and Bone Disorder-prevent-Kidney Failure, Chronic', 'Obesity-put-Chronic Disease', 'Carcinoma, Non-Small-Cell Lung-experience-Neoplasm Metastasis', 'Cardiovascular Diseases-reduced-Atherosclerosis', 'Fibromuscular Dysplasia-lead-Constriction, Pathologic', 'Fibromuscular Dysplasia-lead-Aneurysm', 'Aneurysm-include-Aneurysm, Infected', 'Death-observe-Communicable Diseases', 'Hypercholesterolemia-contribute to-Alzheimer Disease', 'Hypercholesterolemia-contribute-Alzheimer Disease', 'Death-observe-Shock', 'Death-observe-Neoplasms', 'Death-related-Shock', 'Osteopetrosis-prevent-Blindness', 'Diabetes, Gestational-associated-Polycystic Ovary Syndrome', 'Polycystic Ovary Syndrome-associated-Diabetes, Gestational', 'Diabetes, Gestational-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-Diabetes, Gestational', 'Neoplasms-be with-Neoplasm Metastasis', 'Myocardial Infarction-assigned-Thrombosis', 'Thrombosis-seem-Myocardial Infarction', 'Liver Diseases-be in-Cystic Fibrosis', 'Liver Diseases-complicated-Hypertension', 'Cystic Fibrosis-complicated-Hypertension', 'Cystic Fibrosis-emerge-Liver Diseases', 'Death-associated-Candidiasis, Invasive', 'Candidiasis, Invasive-associated-Death', 'Cholecystitis, Acute-be major complication of-Lithiasis', 'Chronic Periodontitis-characterized-Tooth Injuries', 'Communicable Diseases-characterized-Tooth Injuries', 'Delirium-complication of-Neoplasms', 'Stroke-require-Fractures, Bone', 'Peritoneal Neoplasms-undergo surgery for-Multiple Endocrine Neoplasia', 'Peritoneal Neoplasms-present-Multiple Endocrine Neoplasia', 'Peritoneal Neoplasms-associated-Multiple Endocrine Neoplasia', 'Multiple Endocrine Neoplasia-associated-Peritoneal Neoplasms', 'Multiple Endocrine Neoplasia-present-Neoplasm Metastasis', 'Peritoneal Neoplasms-caused-Carcinoid Tumor', 'Peritoneal Neoplasms-present-Neoplasm Metastasis', 'Peritoneal Neoplasms-associated-Neoplasm Metastasis', 'Neoplasm Metastasis-associated-Peritoneal Neoplasms', 'Multiple Endocrine Neoplasia-caused-Carcinoid Tumor', 'Carcinoid Tumor-associated-Neoplasm Metastasis', 'Neoplasm Metastasis-associated-Carcinoid Tumor', 'Neoplasms-give-Death', 'Thrombocythemia, Essential-controlled-Cardiac Complexes, Premature', 'Carcinoma, Hepatocellular-occur in-Fibrosis', 'Asthma-classified-Eosinophilia', 'Inflammation-classified-Eosinophilia', 'Hypertension-be prevalent concern among-HIV Infections', 'Cerebral Infarction-become-Death', 'Cerebral Infarction-refer-Stroke', 'Neoplasms-refer-Stroke', 'Osteoarthropathy, Secondary Hypertrophic-associated-Respiration Disorders', 'Respiration Disorders-associated-Osteoarthropathy, Secondary Hypertrophic', 'Cardiovascular Diseases-determine-Memory Disorders', 'Fractures, Bone-related to-Osteoporosis', 'Hypertension-risk of-Alzheimer Disease', 'Neoplasms-compute-Lung Neoplasms', 'Neoplasms-of history be-Lung Neoplasms', 'Neoplasms-identify-Breast Neoplasms', 'Seizures-correlated-Death', 'Neoplasm Metastasis-irradiated-Neoplasms', 'Neoplasms-irradiated-Neoplasm Metastasis', 'Neoplasms-irradiated-Fractures, Bone', 'Malocclusion-used-Cerebral Palsy', 'Malocclusion-identify-Cerebral Palsy', 'Cerebral Palsy-compare-Osteoarthritis', 'Neoplasms-categorized-Stomach Neoplasms', 'Motor Neuron Disease-be term for-Neurodegenerative Diseases', 'Lung Neoplasms-be lead cause of-Neoplasms', 'Death-offset-Cardiovascular Diseases', 'Death-be related to-Sepsis', 'Death-suffer-Sepsis', 'Pneumococcal Infections-include-Death', 'Communicable Diseases-raise-Death', 'Diabetes Mellitus-aged-Kidney Failure, Chronic', 'Prader-Willi Syndrome-associated-Obesity', 'Obesity-associated-Prader-Willi Syndrome', 'Death-warrant-Glucose Metabolism Disorders', 'Wounds and Injuries-compare-Heart Failure', 'Wounds and Injuries-preexist-Heart Failure', 'Inflammation-accompanied-Periodontitis', 'Inflammation-accompanied-Graft vs Host Disease', 'Periodontitis-accompanied-Graft vs Host Disease', 'Muscular Atrophy, Spinal-characterized-Muscle Weakness', 'Muscular Atrophy, Spinal-result-Death', 'Genetic Diseases, Inborn-result-Death', 'Neoplasm Metastasis-fail-Death', 'Prostatic Neoplasms-developed-Neoplasms', 'Muscular Atrophy, Spinal-lead-Muscle Weakness', 'Liver Cirrhosis-associated-Ulcer', 'Ulcer-associated-Liver Cirrhosis', 'Liver Cirrhosis-decline-Death', 'Heart Arrest-slow-Muscular Atrophy, Spinal', 'Peptic Ulcer-lead-Death', 'Peptic Ulcer-lead-Liver Cirrhosis', 'Hemorrhage-lead-Liver Cirrhosis', 'HIV Infections-emerge-Hepatitis C', 'Death-reported-Myositis Ossificans', 'HIV Infections-emerge-Hepatitis B', 'Intracranial Aneurysm-be in-Subarachnoid Hemorrhage', 'Neoplasm Metastasis-result-Pain', 'Neoplasm Metastasis-result-Nervous System Diseases', 'Coronary Artery Disease-from death be-Heart Arrest', 'Colorectal Neoplasms-suggest-Drug-Related Side Effects and Adverse Reactions', 'Neoplasms-cause-Infertility, Female', 'Death-use-Obesity', 'Sweet Syndrome-develop-Pain', 'Diabetes Mellitus-select-Death', 'Urinary Bladder Neoplasms-identified-Neoplasms', 'Lung Diseases-be frequent cause in-Fibrosis', 'Meningeal Neoplasms-present-von Hippel-Lindau Disease', 'Prostatic Neoplasms-based-Neoplasms', 'Death-incorporate-Neurologic Manifestations', 'Hip Fractures-incorporate-Neurologic Manifestations', 'Death-performed-Adenomatous Polyposis Coli', 'Death-main causes of be-Digestive System Neoplasms', 'Neoplasms-treated-Fractures, Bone', 'Chronic Disease-worsen-Neoplasms', 'Respiratory Distress Syndrome-enhance-Inflammation', 'Respiratory Distress Syndrome-aggravate-Inflammation', 'Stroke-receive-Hypertension', 'Hypertension-decrease-Heart Failure', 'Hypertension-lead-Syncope', 'Death-lead-Syncope', 'Heart Failure-include mortality be-Cardiovascular Diseases', 'Cardiovascular Diseases-lead-Syncope', 'Lymphoma-be dominant type of-Neoplasms', 'Osteoporosis-balance-Gastroesophageal Reflux', 'Osteoporosis-balance-Musculoskeletal Pain', 'Gastroesophageal Reflux-reduce-Fractures, Bone', 'Musculoskeletal Pain-reduce-Fractures, Bone', 'Heart Failure-shorten-Inflammation', 'Neoplasm Metastasis-cause-Fractures, Bone', 'Central Nervous System Neoplasms-involve-Retinal Neoplasms', 'Carcinoma, Hepatocellular-vary-Neoplasms', 'Neoplasms-occur with-Fibrosis', 'Lung Neoplasms-describe-Death', 'Neoplasms-describe-Death', 'Death-dominated-Cardiovascular Diseases', 'Death-dominated-Neoplasms', 'Death-dominated-Respiratory Tract Diseases', 'Infections-affect-Death', 'Breast Neoplasms-be major cause of-Neoplasms', 'Breast Neoplasms-be major cause of-Death', 'Neoplasms-be major cause of-Death', 'Death-categorized-Poisoning', 'Poisoning-categorized-Death', 'Poisoning-include-Death', 'Death-include-Poisoning', 'Death-experience-Death, Sudden, Cardiac', 'Cardiovascular Diseases-cancer-Heart Diseases', 'Immunologic Deficiency Syndromes-demonstrate-Myalgia', 'Hemophilia A-inform-Obesity', 'Obesity-treat-Hemophilia A', 'Exocrine Pancreatic Insufficiency-appear-Cystic Fibrosis', 'Hodgkin Disease-treated-Breast Neoplasms', 'Neoplasms-confirm-Prostatic Neoplasms', 'Obesity-be with-Chronic Disease', 'Obesity-beneficiaries-Chronic Disease', 'Ureteral Calculi-treat-Constriction, Pathologic', 'Spinal Diseases-be source in-Neoplasms', 'Neoplasm Metastasis-be common in-Neoplasms', 'Hepatitis B-infected-Infections', 'Hepatitis B-include-Carcinoma, Hepatocellular', 'Hepatitis B-include-Fibrosis', 'Hepatitis B-include-Death', 'Carcinoma, Hepatocellular-include-Infections', 'Fibrosis-include-Infections', 'Chronic Disease-increased-Cardiovascular Diseases', 'Metabolic Syndrome-characterized-Atherosclerosis', 'Death-be with-Myocardial Infarction', 'Death-used-Myocardial Infarction', 'Cystic Fibrosis-known-Burkholderia Infections', 'Pneumonia-known-Burkholderia Infections', 'Pain-provide-Arthritis', 'Death-Hispanic patients with-Cystic Fibrosis', 'Psoriasis-mediated-Inflammation', 'Death-include-Osteoarthritis', 'Mastocytosis, Systemic-caused-Immunologic Deficiency Syndromes', 'Coronary Artery Disease-characterize-Death', 'Thromboembolism-be in-Atrial Fibrillation', 'Death-experience-Spinal Cord Injuries', 'Spinal Cord Injuries-confirm-Death', 'Neoplasm Metastasis-be serious complication of-Neoplasms', 'Neoplasm Metastasis-occur-Neoplasms', 'Kidney Neoplasms-include-Neoplasms', 'Growth Disorders-associated-Turner Syndrome', 'Turner Syndrome-associated-Growth Disorders', 'Lung Neoplasms-be with-Neoplasm Metastasis', 'Arthritis-follow-Diabetes Mellitus', 'Diabetes Mellitus-controlled-Coronaviridae Infections', 'Lung Neoplasms-be with-Liver Cirrhosis', 'Diabetes Mellitus-converted-Insulin Resistance', 'Meibomian Gland Dysfunction-irradiated-Neoplasms', 'Glioblastoma-irradiated-Neoplasms', 'Cardiovascular Diseases-live-Obesity', 'Cerebral Infarction-be in-Atrial Fibrillation', 'Stroke-be in-Atrial Fibrillation', 'Atrial Fibrillation-underutilized-Stroke', 'Stomach Neoplasms-admitted-Neoplasms', 'Cardiovascular Diseases-be in-Arthritis, Rheumatoid', 'Death-be in-Arthritis, Rheumatoid', 'IgA Vasculitis-increase-Death', 'Coronary Artery Disease-exist-Renal Insufficiency, Chronic', 'Heart Failure-exist-Metabolic Diseases', 'Heart Failure-exist-Gastrointestinal Diseases', 'Ulcer-be in-Diabetes Mellitus', 'Heart Failure-exist-Lung Diseases', 'Heart Failure-exist-Hematologic Diseases', 'Heart Failure-exist-Urologic Diseases', 'Heart Failure-exist-Renal Insufficiency, Chronic', 'Heart Failure-exist-Neoplasms', 'Hypertension-exist-Renal Insufficiency, Chronic', 'Metabolic Diseases-exist-Renal Insufficiency, Chronic', 'Gastrointestinal Diseases-exist-Renal Insufficiency, Chronic', 'Lung Diseases-exist-Renal Insufficiency, Chronic', 'Hematologic Diseases-exist-Renal Insufficiency, Chronic', 'Urologic Diseases-exist-Renal Insufficiency, Chronic', 'Renal Insufficiency, Chronic-exist-Neoplasms', 'Coronary Artery Disease-manage-Glaucoma', 'Colitis, Ulcerative-increase-Death', 'Colitis-increase-Death', 'Death-occur-Cerebrovascular Disorders', 'Death-be in-Hypertension', 'Pancreatitis-compare-Pancreatic Neoplasms', 'Pancreatic Neoplasms-considered-Neoplasms', 'Diabetes Mellitus-treat-Cardiovascular Diseases', 'Death-cause-HIV Infections', 'Neoplasms-patients with-Thyroid Cancer, Papillary', 'Neoplasms-diagnosed-Thyroid Cancer, Papillary', 'Neoplasm Metastasis-be likely among-Thyroid Cancer, Papillary', 'Lissencephaly-develop-Seizures', 'Seizures-develop-Microcephaly', 'Alzheimer Disease-report-Psychophysiologic Disorders', 'Infertility, Female-remain-Infertility, Male', 'Obesity-be with-Metabolic Syndrome', 'Dementia-act-Hypertension', 'Breast Neoplasms-screen-Neoplasms', 'Diabetes Mellitus-be common extra pulmonary complication of-Cystic Fibrosis', 'Glaucoma-be among-Blindness', 'Cardiovascular Diseases-compete-Death', 'Aortic Diseases-depend-Hypertension', 'Ulcer-include-Diabetic Foot', 'Osteomyelitis-include-Diabetic Foot', 'Gangrene-include-Diabetic Foot', 'Arrhythmias, Cardiac-result-Death', 'Neurodegenerative Diseases-characterized-Respiratory Tract Infections', 'Scoliosis-Patients with-Muscular Dystrophy, Duchenne', 'Scoliosis-develop-Muscular Dystrophy, Duchenne', 'Diabetic Nephropathies-be lead cause of-Kidney Failure, Chronic', 'Obesity-be with-Kidney Failure, Chronic', 'Death-look at-Diabetes Mellitus', 'Diabetes Mellitus-listed-Death', 'Cerebral Infarction-be independent predictor for-Death', 'Lipodystrophy, Congenital Generalized-lead to-Death', 'Drug Hypersensitivity-lead-Death', 'Neuronal Ceroid-Lipofuscinoses-cause-Epilepsies, Myoclonic', 'Lipodystrophy, Congenital Generalized-lead-Sleep Initiation and Maintenance Disorders', 'Neuronal Ceroid-Lipofuscinoses-lead-Blindness', 'Genetic Diseases, Inborn-lead-Sleep Initiation and Maintenance Disorders', 'Neuronal Ceroid-Lipofuscinoses-cause-Death', 'Lysosomal Storage Diseases-cause-Epilepsies, Myoclonic', 'Lysosomal Storage Diseases-lead-Blindness', 'Lysosomal Storage Diseases-cause-Death', 'Epilepsies, Myoclonic-lead-Blindness', 'Blindness-lead-Death', 'Metabolic Syndrome-determine-Dyslipidemias', 'Death-Individuals with-Chronic Disease', 'HIV Infections-lead-Metabolic Diseases', 'Stomach Neoplasms-show-Neoplasms', 'Metabolic Syndrome-require-Dyslipidemias', 'Stroke-cause-Hemorrhage', 'Metabolic Syndrome-require-Hypertension', 'Thromboembolism-cause-Hemorrhage', 'Atrial Fibrillation-prevent-Death', 'Atrial Fibrillation-cause-Hemorrhage', 'Acidosis-independent factor on-Death', 'Acidosis-represent-Death', 'Breast Neoplasms-cause-Death', 'Breast Neoplasms-compare-Heart Diseases', 'Breast Neoplasms-compare-Death', 'Gastric Outlet Obstruction-caused-Stomach Neoplasms', 'Infections-be common epiphenomenon of-Diabetic Foot', 'Infections-common reason for-Diabetes Mellitus', 'Tracheoesophageal Fistula-be devastate complication of-Neoplasms', 'Tracheoesophageal Fistula-included-Lung Neoplasms', 'Neoplasms-diagnosed-Head and Neck Neoplasms', 'Neoplasm Metastasis-provide-Pain', 'Plasmablastic Lymphoma-accompanied-Fecal Incontinence', 'Neoplasms-accompanied-Fecal Incontinence', 'Coma-used-Intracranial Hypertension', 'Intracranial Hypertension-follow-Brain Injuries, Traumatic', 'Renal Insufficiency, Chronic-relate to-Chronic Disease', 'Renal Insufficiency, Chronic-relate-Diabetes Mellitus', 'Renal Insufficiency, Chronic-relate-Chronic Disease', 'Hypertension-develop-Brain Injuries, Traumatic', 'Diabetes Mellitus-fit-Seizures', 'Communicable Diseases-obtained-Death', 'Liver Cirrhosis, Biliary-lead-Liver Diseases', 'Liver Cirrhosis, Biliary-lead-Death', 'Death-associated-Enteritis', 'Enteritis-associated-Death', 'Enteritis-be in-Acquired Immunodeficiency Syndrome', 'Opportunistic Infections-related-Immunologic Deficiency Syndromes', 'Apnea-predict-Death', 'Paralysis-review-Neoplasms', 'Neoplasms-provide-Breast Neoplasms', 'Leukemia-provide-Breast Neoplasms', 'Pleural Effusion, Malignant-relieve-Dyspnea', 'Death-derived-Myocardial Infarction', 'Death-recorded-Myocardial Infarction', 'Death-derived-Stroke', 'Death-recorded-Stroke', 'Death-derived-Heart Failure', 'Death-recorded-Heart Failure', 'Death-derived-Renal Insufficiency', 'Death-recorded-Renal Insufficiency', 'Neoplasms-face-Death', 'Death-change-Cerebral Palsy', 'Cardiomegaly-AVE8134-Fibrosis', 'Cardiomegaly-AVE8134-Heart Diseases', 'Kidney Diseases-be strong predictor of-Cardiovascular Diseases', 'Kidney Diseases-be strong predictor of-Diabetes Mellitus', 'Motion Sickness-seen-Thalassemia', 'Diabetes Mellitus, Type 2-identified-Kidney Diseases', 'Diabetes Mellitus-projected-Kidney Diseases', 'Rubella-undergo-Leukemia', 'Colorectal Neoplasms-proportion of-Neoplasms', 'Acquired Immunodeficiency Syndrome-result in-Death', 'HIV Infections-find-Atherosclerosis', 'Coronary Artery Disease-find-Atherosclerosis', 'Death-describe-Chronic Disease', 'Coronary Artery Disease-patients from-HIV Infections', 'Coronary Artery Disease-referred-HIV Infections', 'HIV Infections-referred-Dyslipidemias', 'Coronary Artery Disease-referred-Dyslipidemias', 'Papillomavirus Infections-associated-Uterine Cervical Neoplasms', 'Uterine Cervical Neoplasms-associated-Papillomavirus Infections', 'Pneumothorax-be complication of-HIV Infections', 'Obesity-related-Death', 'Pneumothorax-be in-Acquired Immunodeficiency Syndrome', 'Cardiomyopathy, Hypertrophic-caused-Heart Diseases', 'Pneumothorax-associated-Pneumocephalus', 'Pneumocephalus-associated-Pneumothorax', 'Pneumothorax-treat-Infections', 'Acquired Immunodeficiency Syndrome-associated-Pneumocephalus', 'Pneumocephalus-associated-Acquired Immunodeficiency Syndrome', 'Acquired Immunodeficiency Syndrome-treat-Infections', 'Pneumocephalus-treat-Infections', 'HIV Infections-remain-Neurodegenerative Diseases', 'Arteriosclerosis-caused-Dementia, Vascular', 'Arteriosclerosis-caused-Alzheimer Disease', 'Paralysis-caused-Blood Platelet Disorders', 'Communicable Diseases-be in-Chronic Disease', 'Huntington Disease-associated-Pancytopenia', 'Pancytopenia-associated-Huntington Disease', 'Infections-leading-Death', 'Death-be in-Silicosis', 'Carcinoma-Patients with-Stomach Neoplasms', 'Carcinoma-show-Stomach Neoplasms', 'Hemophilia A-be with-Atrial Fibrillation', 'Cachexia-cause morbidity in-Lung Neoplasms', 'Neoplasms-determine-Neoplasm Metastasis', 'Brain Death-increase compare-Death', 'Lymphangiectasis, Intestinal-characterized-Lymphatic Diseases', 'Ascites-show-Hypoproteinemia', 'Ascites-show-Hypoalbuminemia', 'Ascites-show-Agammaglobulinemia', 'Ureteral Obstruction-be in-Neoplasms', 'Ureteral Obstruction-inserted-Neoplasms', 'Cystic Fibrosis-occur-Signs and Symptoms, Respiratory', 'Pancreatic Neoplasms-accompanied-Cholestasis', 'Pancreatic Neoplasms-accompanied-Duodenal Obstruction', 'Melioidosis-occur-Signs and Symptoms, Respiratory', 'Communicable Diseases-occur-Signs and Symptoms, Respiratory', 'Carcinoma, Hepatocellular-experience-Postpartum Hemorrhage', 'Carcinoma, Hepatocellular-undergo-Delirium', 'Neoplasm Metastasis-be responsive due-Hypoxia', 'Osteomyelitis-develop-Nervous System Diseases', 'Osteomyelitis-develop-Spinal Diseases', 'Nervous System Diseases-intractable cases with-Osteomyelitis', 'Nervous System Diseases-develop-Osteomyelitis', 'Death-estimate-Infections', 'Nervous System Diseases-intractable cases-Spinal Diseases', 'Nervous System Diseases-course-Spinal Diseases', 'Prostatic Neoplasms-tend-Thyroid Neoplasms', 'Prostatic Neoplasms-obtained-Neoplasms', 'Chronic Disease-be in-Anemia, Sickle Cell', 'Neoplasms-be with-Disease Progression', 'Cerebral Infarction-occur-Neoplasms', 'Intracranial Hemorrhages-occur-Neoplasms', 'Cerebral Infarction-treated-Stroke', 'Neoplastic Syndromes, Hereditary-treated-Stroke', 'Neoplastic Syndromes, Hereditary-i-Cerebral Infarction', 'Death-i-Cerebral Infarction', 'Hemorrhage-i-Cerebral Infarction', 'Polycythemia Vera-affected-Thrombosis', 'Essential Tremor-affected-Thrombosis', 'Neoplasm Metastasis-lead-Carcinoma, Ductal', 'Brain Injuries, Traumatic-assess-Death', 'Brain Injuries, Traumatic-complete-Death', 'Seminoma-reduce-Neoplasms', 'Stroke-include-Sleep Wake Disorders', 'Sleep Wake Disorders-be become-Stroke', 'Death-stratify-Dementia', 'Leishmaniasis, Visceral-averted-Death', 'Death-use-Leishmaniasis, Visceral', 'Leishmaniasis, Visceral-produce-Death', 'Spinal Cord Injuries-incur-Death', 'Limb Deformities, Congenital-present-Communicable Diseases', 'Death-analysed-Glaucoma', 'Cystic Fibrosis-considered-Genetic Diseases, Inborn', 'Sleep Apnea Syndromes-include-Diabetes Mellitus', 'Neurodegenerative Diseases-include-Diabetes Mellitus', 'Postthrombotic Syndrome-include-Diabetes Mellitus', 'Pseudotumor Cerebri-include-Diabetes Mellitus', 'Sleep Apnea Syndromes-include-Hypertension', 'Neurodegenerative Diseases-include-Hypertension', 'Urinary Incontinence-include-Hypertension', 'Postthrombotic Syndrome-include-Hypertension', 'Pseudotumor Cerebri-include-Hypertension', 'Hypertension-occur-Hyperalgesia', 'Vision Disorders-wait-Cataract', 'Aortic Coarctation-become-Hypertension', 'Diabetes Mellitus, Type 2-carry-Coronary Artery Disease', 'Diabetes Mellitus, Type 2-carry-Death', 'Stroke-selected-Foramen Ovale, Patent', 'HIV Infections-compared-Death', 'Acquired Immunodeficiency Syndrome-compared-Death', 'Death-compared-Heart Diseases', 'HIV Infections-compared-Heart Diseases', 'Acquired Immunodeficiency Syndrome-compared-Heart Diseases', 'Acquired Immunodeficiency Syndrome-compared-Neoplasms', 'Stroke-be with-Foramen Ovale, Patent', 'Drug-Related Side Effects and Adverse Reactions-lack-Hypertension', 'Drug-Related Side Effects and Adverse Reactions-lack-Heart Failure', 'Drug-Related Side Effects and Adverse Reactions-lack-Liver Diseases', 'Drug-Related Side Effects and Adverse Reactions-avoided-Peptic Ulcer', 'Takotsubo Cardiomyopathy-manage-Pericardial Effusion', 'Lymphoma-be with-Ulcer', 'Cushing Syndrome-correlated-Death', 'Peripheral Nervous System Diseases-worsen-Neoplasms', 'Arthritis, Rheumatoid-evaluate-Headache Disorders, Secondary', 'Arthritis, Rheumatoid-evaluate-Neoplasms', 'Headache Disorders, Secondary-compare-Neoplasms', 'Headache Disorders, Secondary-evaluate-Neoplasms', 'Obesity-associated-Ventricular Remodeling', 'Ventricular Remodeling-associated-Obesity', 'Arterial Occlusive Diseases-incidence of-Infections', 'Arterial Occlusive Diseases-durations of-Infections', 'Turner Syndrome-predispose-Obesity', 'Turner Syndrome-predispose-Metabolic Diseases', 'Turner Syndrome-predispose-Cardiovascular Diseases', 'Turner Syndrome-predispose-Metabolic Syndrome', 'Obesity-predispose-Metabolic Syndrome', 'Ischemia-mimic-Critical Illness', 'Ischemia-use-Critical Illness', 'Neoplasms-slated-Gastric Outlet Obstruction', 'Scoliosis-managed-Muscular Atrophy, Spinal', 'Gastric Outlet Obstruction-occur due-Neoplasms', 'Gastric Outlet Obstruction-occur-Neoplasms', 'Adrenal Insufficiency-impaired-Infections', 'Carotid Stenosis-defined-Brain Ischemia', 'Genetic Diseases, Inborn-improve-Drug-Related Side Effects and Adverse Reactions', 'Anemia, Hypochromic-improve-Drug-Related Side Effects and Adverse Reactions', 'Anemia-improve-Drug-Related Side Effects and Adverse Reactions', 'Osteoporosis-hospitalized-Fractures, Bone', 'Fractures, Bone-improve-Osteoporosis', 'Neoplasms-assign-Cancer Pain', 'Polycystic Ovary Syndrome-experience-Hypertension', 'Metabolic Syndrome-be with-Non-alcoholic Fatty Liver Disease', 'Spinal Cord Injuries-define-Leukocytosis', 'Infections-define-Leukocytosis', 'Inflammation-define-Leukocytosis', 'Spinal Cord Injuries-be with-Leukocytosis', 'Spinal Cord Injuries-mount-Fever', 'Leukocytosis-mount-Fever', 'Dementia-define-Pneumothorax', 'Muscular Dystrophy, Duchenne-approved-Neuromuscular Diseases', 'Respiratory Insufficiency-be present In-Neuromuscular Diseases', 'Multiple Endocrine Neoplasia Type 1-occur-Multiple Endocrine Neoplasia', 'Neoplasms-be in-Urethral Neoplasms', 'Neoplasms-affect-Breast Neoplasms', 'Lung Neoplasms-be fatal malignancy with-Death', 'Neoplasms-be with-Death', 'Death-included-Multiple Sclerosis', 'Retroperitoneal Neoplasms-achieve-Neoplasms', 'Neoplasms-affect-Colitis, Ulcerative', 'Acquired Immunodeficiency Syndrome-prevent-Arbovirus Infections', 'Acquired Immunodeficiency Syndrome-simulate-Heart Failure', 'Arbovirus Infections-simulate-Heart Failure', 'Neoplasms-prefer-Neutropenia', 'Infertility, Female-include-Primary Ovarian Insufficiency', 'Death-result-Chronic Disease', 'Carcinoma, Squamous Cell-present in-Infections', 'Stomach Neoplasms-referred-Jaundice, Obstructive', 'Jaundice-be common condition in-Neoplasms', 'Heart Diseases-performed-Anemia, Sickle Cell', 'Neoplasms-be third main cause of-Death', 'Cystitis, Interstitial-self-report-Sexual Dysfunction, Physiological', 'Anemia-be frequent finding in-Uremia', 'Osteoporosis-contribute-Alveolar Bone Loss', 'Pulmonary Atresia-present-Ventricular Septal Rupture', 'Hemolytic-Uremic Syndrome-be with-Gastrointestinal Hemorrhage', 'Urinary Bladder Neoplasms-form-Death', 'Osteoarthritis-predict-Death', 'Colorectal Neoplasms-originate-Adenoma', 'Diabetes Mellitus-undergo-Heart Diseases', 'Diabetes Mellitus-indicate-Heart Diseases', 'Death-hospitalized-Fibrosis', 'Leukemia, Myeloid, Acute-include-Death', 'Vision Disorders-known-Sensation Disorders', 'Lupus Erythematosus, Systemic-evaluate-Headache Disorders, Secondary', 'Death-Patients with-Neoplasms', 'Dementia-associated-Coronary Artery Disease', 'Coronary Artery Disease-associated-Dementia', 'Heart Failure-observed-Pain', 'Heart Failure-observed-Pleural Effusion', 'Heart Failure-observed-Osteoarthritis', 'Neoplasms-receive-Adenocarcinoma', 'Neoplasms-receive-Stomach Neoplasms', 'Death-exist-Apnea', 'HIV Infections-make-Cardiovascular Diseases', 'HIV Infections-make-Arrhythmias, Cardiac', 'Head and Neck Neoplasms-obtained-Death', 'Pulmonary Valve Insufficiency-correlate-Tachycardia, Ventricular', 'Ventricular Dysfunction-correlate-Tachycardia, Ventricular', 'Alzheimer Disease-participate-Breast Neoplasms', 'Brain Injuries, Traumatic-lead cause of-Death', 'Brain Injuries, Traumatic-become-Death', 'Sleep Wake Disorders-linked-Wounds and Injuries', 'Heart Failure-observed-Fistula', 'Ulcer-followed-Death', 'Amyloidosis-remain-Hereditary Autoinflammatory Diseases', 'Neoplasms-identify-Colorectal Neoplasms, Hereditary Nonpolyposis', 'Embolism-introduced-Cardiovascular Diseases', 'Death-used-Carcinoma, Hepatocellular', 'Drug-Related Side Effects and Adverse Reactions-tolerated-Neoplasms', 'Colorectal Neoplasms-treat-Neoplasm Metastasis', 'Neoplasms-consider-Immunologic Deficiency Syndromes', 'Neoplasms-predict-Liver Neoplasms', 'Aortic Aneurysm-account-Death', 'Sepsis-reduce-Death', 'Intermittent Claudication-caused-Renal Artery Obstruction', 'Endomyocardial Fibrosis-undergo-Heart Valve Diseases', 'Duodenal Neoplasms-assess-Intestinal Polyposis', 'Adenomatous Polyposis Coli-develop-Polyps', 'Adenoma-develop-Polyps', 'Prostatic Neoplasms-suggest-Death', 'Ischemia-caused-Arterial Occlusive Diseases', 'Stroke-cause-Nervous System Diseases', 'Huntington Disease-made-Chorea', 'HIV Infections-follow-Communicable Diseases', 'HIV Infections-follow-Acquired Immunodeficiency Syndrome', 'Cardiovascular Diseases-mediated-Hypercholesterolemia', 'Cardiovascular Diseases-mediated-Hypertension', 'Cardiovascular Diseases-mediated-Diabetes Mellitus', 'HIV Infections-indicate-Chronic Kidney Disease-Mineral and Bone Disorder', 'Diabetes Mellitus-assessed-Delirium', 'Dementia-assessed-Delirium', 'Renal Insufficiency, Chronic-accompanied-Anemia', 'Renal Insufficiency, Chronic-accompanied-Hypoxia', 'Death-related-Crohn Disease', 'Colonic Diseases-associate-Death', 'Death-associate-Colonic Diseases', 'Death-associated-Hypercalcemia', 'Hypercalcemia-associated-Death', 'Hypercalcemia-occur-Neoplasms', 'Hypercalcemia-occur-Hyperparathyroidism', 'Infections-control-Onchocerciasis', 'Death-control-Onchocerciasis', 'Hypogonadism-present-Sexual Dysfunction, Physiological', 'Atrial Fibrillation-associate-Thromboembolism', 'Thromboembolism-associate-Atrial Fibrillation', 'Arrhythmias, Cardiac-associate-Thromboembolism', 'Thromboembolism-associate-Arrhythmias, Cardiac', 'Arrhythmias, Cardiac-associate-Death', 'Death-associate-Arrhythmias, Cardiac', 'Inflammatory Bowel Diseases-contribute-Pain', 'Diabetes Mellitus-ensue-Death', 'Neoplasms-ensue-Death', 'Bone Marrow Diseases-managed-Lymphoma', 'Crohn Disease-remain-Thrombosis', 'Psychoses, Substance-Induced-termed-Chronic Disease', 'Death-determine-Cerebral Palsy', 'Thalassemia-accompanied-Thromboembolism', 'Breast Neoplasms-depend-Neoplasms', 'Prostatic Neoplasms-miss-Neoplasms', 'Neoplasms-comply-Drug-Related Side Effects and Adverse Reactions', 'Neoplasms-initiate-Diabetes Mellitus', 'Fractures, Bone-represent-Hip Fractures', 'Death-represent-Hip Fractures', 'Osteoporotic Fractures-favour-Osteoporosis', 'Prostatic Neoplasms-related-Death', 'Anemia, Sickle Cell-done-Femur Head Necrosis', 'Anemia, Sickle Cell-modify-Femur Head Necrosis', 'Cerebral Palsy-demonstrate-Movement Disorders', 'Patellofemoral Pain Syndrome-discriminate-Cerebral Palsy', 'Hemorrhage-prevent-Hypertension', 'Hemorrhage-extend-Hypertension', 'Hyperemia-increase-Fibrosis', 'Hypertension-initiate-Ocular Hypertension', 'Hypertension-caused-Glaucoma', 'Ocular Hypertension-caused-Glaucoma', 'Ocular Hypertension-initiate-Blindness', 'Brain Edema-involve-Brain Neoplasms', 'Brain Edema-explain-Brain Neoplasms', 'Dysautonomia, Familial-develop-Kidney Failure, Chronic', 'Muscular Atrophy, Spinal-follow-Muscular Dystrophy, Duchenne', 'Muscular Dystrophy, Duchenne-exist-Neuromuscular Diseases', 'Muscular Diseases-exist-Neuromuscular Diseases', 'Dermatitis, Atopic-control-Psoriasis', 'Intellectual Disability-include-Abnormalities, Drug-Induced', 'Growth Disorders-include-Abnormalities, Drug-Induced', 'Microcephaly-include-Abnormalities, Drug-Induced', 'Heart Defects, Congenital-include-Abnormalities, Drug-Induced', 'Kidney Diseases-include-Abnormalities, Drug-Induced', 'Hypopituitarism-caused-Cardiovascular Diseases', 'Sialadenitis-exclude-Acromegaly', 'Sialadenitis-exclude-Cushing Syndrome', 'Sialadenitis-observed-Death', 'Sialadenitis-observed-Neoplasms', 'Acromegaly-observed-Death', 'Acromegaly-observed-Neoplasms', 'Acromegaly-exclude-Neoplasms', 'Carcinoma, Hepatocellular-originate-Neoplasm Metastasis', 'Cushing Syndrome-observed-Death', 'Cushing Syndrome-observed-Neoplasms', 'Cushing Syndrome-exclude-Neoplasms', 'Neoplasm Metastasis-originate-Carcinoma, Lewis Lung', 'Vomiting-referred-Diabetes Mellitus', 'Neoplasm Metastasis-originate-Melanoma', 'Vomiting-relieve-Gastroparesis', 'Lung Neoplasms-stratify-Neoplasms', 'Vomiting-give-Renal Insufficiency', 'Gastroparesis-give-Renal Insufficiency', 'Aortic Aneurysm, Abdominal-operated-Death', 'Hepatitis C-recognized-Liver Cirrhosis', 'Multifocal Choroiditis-reflect-Macular Degeneration', 'Macular Degeneration-reflect-Communicable Diseases', 'Macular Degeneration-reflect-Acquired Immunodeficiency Syndrome', 'Neoplasms-receive-Breast Neoplasms', 'Dyspnea-alleviate-Heart Failure', 'Dyspnea-Provide-Death', 'Dysbiosis-found-Obesity', 'Cardiovascular Diseases-aid-Diabetes Mellitus', 'Diabetes Mellitus-comprise-Cardiovascular Diseases', 'Diabetes Mellitus-comprise-Stroke', 'Diabetes Mellitus-comprise-Myocardial Infarction', 'Diabetes Mellitus-derived-Death', 'Diabetes Mellitus-generate-Dysbiosis', 'Hypercholesterolemia-generate-Dysbiosis', 'Thalassemia-lead-Death', 'Staphylococcal Infections-occure-Infections', 'Dyskeratosis Congenita-sustain-Fractures, Bone', 'Diabetes Mellitus-examine-Glucose Intolerance', 'Carcinoma, Hepatocellular-result-Death', 'Spinal Cord Injuries-represent-Urinary Bladder Neoplasms', 'Spinal Cord Injuries-diagnosed-Urinary Bladder Neoplasms', 'Lung Neoplasms-incorporate-Death', 'Lung Neoplasms-screen-Death', 'Sleep Apnea, Obstructive-assess-Memory Disorders', 'Cystic Fibrosis-associated-Pain', 'Pain-associated-Cystic Fibrosis', 'Cystic Fibrosis-affect-Pain', 'Pain-perceived-Cystic Fibrosis', 'Aortic Aneurysm, Abdominal-compare-Aneurysm', 'Thrombosis-increase-Hemorrhage', 'Amyotrophic Lateral Sclerosis-lead-Malnutrition', 'Neurodegenerative Diseases-lead-Malnutrition', 'HIV Infections-receive-Colorectal Neoplasms', 'Aneurysm-defined-Neurologic Manifestations', 'Chronic Disease-used-Obesity', 'Brain Injuries, Traumatic-associate-Death', 'Death-associate-Brain Injuries, Traumatic', 'Plasmacytoma-evaluated-Pain', 'Infections-develop-Liver Failure', 'Hepatitis B, Chronic-develop-Liver Failure', 'Neoplasms-report-Lung Diseases', 'Neoplasms-report-Arthritis', 'Neoplasms-report-Urinary Incontinence', 'Neoplasms-report-Obesity', 'Stomach Neoplasms-occur-Zollinger-Ellison Syndrome', 'Aortic Aneurysm, Abdominal-decrease-Rupture', 'Hemorrhage-derived-Purpura, Thrombocytopenic, Idiopathic', 'Tuberculosis-show-Death', 'Hemochromatosis-diagnosed-Muscle Weakness', 'Hemochromatosis-diagnosed-Lethargy', 'Hemochromatosis-diagnosed-Hyperpigmentation', 'Hemochromatosis-diagnosed-Diabetes Mellitus', 'Hemochromatosis-diagnosed-Arthralgia', 'Hemochromatosis-diagnosed-Erectile Dysfunction', 'Hemochromatosis-diagnosed-Brugada Syndrome', 'Pelizaeus-Merzbacher Disease-monitored-Neoplasms', 'Eunuchism-live-HIV Infections', 'Rhinitis, Allergic-characterized-Drug Hypersensitivity', 'Leukodystrophy, Metachromatic-mediated-Hearing Loss', 'Rhinitis, Allergic-characterized-Asthma', 'Pain-maintain-Sleep Initiation and Maintenance Disorders', 'Diabetes Mellitus-become-Blindness', 'Cardiovascular Diseases-remain-Renal Insufficiency', 'Death-evolve-Renal Insufficiency', 'Neoplasms-develop-Delirium', 'Cellulitis-seen-Neoplasms', 'Infertility, Female-related-Neoplasms', 'Myocardial Infarction-identified-Heart Diseases', 'Dementia-overtreated-Diabetes Mellitus', 'Thrombocytosis-characterized-Thrombosis', 'Thrombocytosis-characterized-Primary Myelofibrosis', 'Myeloproliferative Disorders-characterized-Thrombocytosis', 'Myeloproliferative Disorders-characterized-Thrombosis', 'Myeloproliferative Disorders-characterized-Primary Myelofibrosis', 'Chronic Disease-known-Death', 'Polycythemia Vera-characterized-Polycythemia', 'Polycythemia Vera-include-Leukocytosis', 'Polycythemia Vera-include-Splenomegaly', 'Polycythemia Vera-include-Thrombosis', 'Polycythemia Vera-include-Hemorrhage', 'Polycythemia Vera-include-Pruritus', 'Aneurysm-reduce-Dementia', 'Polycythemia Vera-prevent-Cardiac Complexes, Premature', 'Myeloproliferative Disorders-characterized-Polycythemia', 'Myeloproliferative Disorders-include-Leukocytosis', 'Myeloproliferative Disorders-include-Splenomegaly', 'Myeloproliferative Disorders-include-Thrombosis', 'Myeloproliferative Disorders-include-Hemorrhage', 'Genetic Diseases, Inborn-characterized-Musculoskeletal Diseases', 'Myeloproliferative Disorders-include-Pruritus', 'Myeloproliferative Disorders-include-Leukemia', 'Polycythemia-include-Leukocytosis', 'Polycythemia-include-Splenomegaly', 'Polycythemia-include-Thrombosis', 'Polycythemia-include-Hemorrhage', 'Polycythemia-include-Pruritus', 'Motor Neuron Disease-include-Heredodegenerative Disorders, Nervous System', 'Epilepsy, Benign Neonatal-result-Atherosclerosis', 'Atherosclerosis-reduce-Cardiovascular Diseases', 'Glioblastoma-represent-Brain Neoplasms', 'Neoplasms-yield-Thyroid Neoplasms', 'Neoplasms-report-Lung Neoplasms', 'Neoplasms-report-Colorectal Neoplasms', 'Sarcoma-evaluate-Neurofibrosarcoma', 'Hepatitis C-simulated-Infections', 'Neoplasms-observed-Lung Neoplasms', 'Huntington Disease-include-Communicable Diseases', 'Lung Neoplasms-estimated-Coronary Artery Disease', 'Lung Neoplasms-treated-Coronary Artery Disease', 'Lung Neoplasms-estimated-Colorectal Neoplasms', 'Coronary Artery Disease-treated-Colorectal Neoplasms', 'Endometrial Neoplasms-detect-Colorectal Neoplasms, Hereditary Nonpolyposis', 'Neoplasms-detect-Colorectal Neoplasms, Hereditary Nonpolyposis', 'Neoplasm Metastasis-reveal-Neoplasms', 'Diabetes Mellitus-related-Fibrosis', 'Retinal Diseases-followed-Kidney Failure, Chronic', 'Retinal Diseases-followed-Blindness', 'Dysplastic Nevus Syndrome-progress-Neoplasms', 'Colonic Neoplasms-prolong-Inflammatory Bowel Diseases', 'Arbovirus Infections-associated-Chemical and Drug Induced Liver Injury', 'Chemical and Drug Induced Liver Injury-associated-Arbovirus Infections', 'Arbovirus Infections-associated-Anemia', 'Anemia-associated-Arbovirus Infections', 'Anemia-include-Chemical and Drug Induced Liver Injury', 'Heart Diseases-identify-Death', 'Heart Diseases-performed-Death', 'Multiple Sclerosis-observed-Pleural Effusion', 'Infections-become-Cardiac Complexes, Premature', 'Infections-become-Granulomatous Disease, Chronic', 'Osteoporosis-encountered-Drug Hypersensitivity', 'Osteoporosis-used-Drug Hypersensitivity', 'Dementia-show-Death', 'Death-use-Respiratory Insufficiency', 'Hemophilia A-followed-Hemorrhage', 'Genetic Diseases, Inborn-characterized-Pain', 'Pain-perceive-Sleep Initiation and Maintenance Disorders', 'Genetic Diseases, Inborn-characterized-Sleep Initiation and Maintenance Disorders', 'Sleep Initiation and Maintenance Disorders-characterized-Contusions', 'Sleep Initiation and Maintenance Disorders-characterized-Inflammation', 'Sleep Initiation and Maintenance Disorders-characterized-Fractures, Bone', 'Death-show-Multiple Sclerosis', 'Osteomyelitis-affect-Anemia', 'Alzheimer Disease-accumulate-Nervous System Diseases', 'Death-resuscitate-Wounds and Injuries', 'Neoplasms-exhibit-Chronic Disease', 'Neoplasms-exhibit-Death', 'Hemolytic-Uremic Syndrome-disturb-Voice Disorders', 'Fibrosis-identified-Hemorrhage', 'Fibrosis-identified-Brain Diseases', 'Fibrosis-identified-Ascites', 'Fibrosis-identified-Hepatopulmonary Syndrome', 'Fibrosis-identified-Jaundice', 'Renal Insufficiency, Chronic-follow-Death', 'Hip Fractures-analyzed-Fractures, Bone', 'Neutropenia-occur-Prostatic Neoplasms', 'Non-alcoholic Fatty Liver Disease-characterized-Fatty Liver', 'Coronary Artery Disease-represent-Death', 'Drug-Related Side Effects and Adverse Reactions-evaluate-Cancer Pain', 'Carcinoma, Hepatocellular-treat-Neoplasm Metastasis', 'Chronic Disease-linked-Obesity', 'Dementia-prescribed-Death', 'Osteogenesis Imperfecta-exhibit-Musculoskeletal Diseases', 'Osteogenesis Imperfecta-exhibit-Fractures, Malunited', 'Chronic Kidney Disease-Mineral and Bone Disorder-follow-Osteogenesis Imperfecta', 'Inflammation-improve-Spinal Cord Injuries', 'Aortic Aneurysm, Abdominal-affected-Aneurysm', 'Neoplasms-coexist-Aortic Aneurysm', 'Spinal Cord Injuries-identify-Death', 'Urinary Tract Infections-improve-Neurogenic Bowel', 'Fecal Incontinence-improve-Neurogenic Bowel', 'Neoplasms-complete-Fatigue', 'Death-derive-Diabetes Mellitus', 'Death-listed-Diabetes Mellitus', 'Osteolysis-occur-Bone Neoplasms', 'Jaundice, Obstructive-undergo-Stomach Neoplasms', 'Neoplasm Metastasis-originated-Digestive System Neoplasms', 'Neoplasm Metastasis-considered-Neoplasms', 'Carbamoyl-Phosphate Synthase I Deficiency Disease-provide-Death', 'Leukemia, Myeloid, Acute-considered-Neoplasms', 'Death-performed-Liver Cirrhosis', 'Death-contribute-Liver Cirrhosis', 'Neoplasms-experience-Dyspnea', 'Dyspnea-reduce-Neoplasms', 'Colorectal Neoplasms-obtained-Neoplasms', 'Small Cell Lung Carcinoma-reduce-Venous Thromboembolism', 'Small Cell Lung Carcinoma-reduce-Lung Neoplasms', 'Spinal Cord Injuries-exhibit-Cerebrovascular Disorders', 'Spinal Cord Injuries-exacerbate-Cerebrovascular Disorders', 'Acromegaly-caused-Pituitary Diseases', 'Neoplasms-use-Gastric Outlet Obstruction', 'Hemophilia A-follow-Obesity', 'SCGB1A1-associated-Pulmonary Disease, Chronic Obstructive', 'Pulmonary Disease, Chronic Obstructive-associated-SCGB1A1', 'Dyspnea-relieve-Pulmonary Disease, Chronic Obstructive', 'Diabetes Mellitus, Type 2-treated-Diabetes Mellitus', 'Cardiovascular Diseases-increased-Chronic Disease', 'Hepatitis B, Chronic-reduce-Liver Cirrhosis', 'Diabetes Mellitus-predicted-Death', 'Obesity-connected-Metabolic Diseases', 'Esophageal Achalasia-preferred-Kearns-Sayre Syndrome', 'Esophageal Achalasia-prevent-Gastroesophageal Reflux', 'Kearns-Sayre Syndrome-prevent-Gastroesophageal Reflux', 'Joint Diseases-develop-Hemophilia A', 'Joint Diseases-treat-Infections', 'Neoplasm Metastasis-assess-Kidney Diseases, Cystic', 'Death-predict-Pancreatitis', 'Heart Diseases-develop-Pulmonary Arterial Hypertension', 'HIV Infections-recorded-Death', 'Femoral Neck Fractures-represent-Death', 'Obesity-associated-Sleep Apnea, Obstructive', 'Sleep Apnea, Obstructive-associated-Obesity', 'Endocrine System Diseases-associated-Death', 'Death-associated-Endocrine System Diseases', 'Endocrine System Diseases-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-Endocrine System Diseases', 'Carcinoma, Hepatocellular-become-Acquired Immunodeficiency Syndrome', 'Carcinoma, Hepatocellular-define-Acquired Immunodeficiency Syndrome', 'Cardiovascular Diseases-confer-Diabetes Mellitus', 'Cardiovascular Diseases-result-Diabetes Mellitus', 'Ulcer-reduce-Death', 'Death-determine-Cardiovascular Diseases', 'Cardiovascular Diseases-double-Death', 'Hip Fractures-increase-Hypertension, Pulmonary', 'Hypertension, Pulmonary-increase-Death', 'Liver Diseases-shorten-Death', 'HIV Infections-prescribe-Acquired Immunodeficiency Syndrome', 'Heart Diseases-exacerbated-Obesity', 'Chemical and Drug Induced Liver Injury-enable-Carcinoma, Hepatocellular', 'Fibrosis-enable-Carcinoma, Hepatocellular', 'Death-influenced-Chronic Disease', 'Ventricular Dysfunction-associated-Heart Failure', 'Heart Failure-associated-Ventricular Dysfunction', 'Carcinoma, Hepatocellular-used-Chemical and Drug Induced Liver Injury', 'Carcinoma, Hepatocellular-undergo-Chemical and Drug Induced Liver Injury', 'Carcinoma, Hepatocellular-used-Fibrosis', 'Carcinoma, Hepatocellular-undergo-Fibrosis', 'Rhabdomyosarcoma-misdiagnosed-Mastoiditis', 'Dyspnea-include-Signs and Symptoms, Respiratory', 'Communicable Diseases-assess-Death', 'Death-recover-Pneumococcal Infections', 'Melanoma-suffer-Neoplasms', 'Neoplasm Invasiveness-influence-Spinal Cord Injuries', 'Spinal Cord Injuries-influence-Urinary Bladder Neoplasms', 'Heart Diseases-coexist-Diabetes Mellitus, Type 2', 'Cardiovascular Diseases-coexist-Diabetes Mellitus, Type 2', 'Diabetes Mellitus-sustain-Myocardial Infarction', 'Hyperparathyroidism-characterized-Hyperplasia', 'Hyperparathyroidism-characterized-Metabolic Diseases', 'Stomach Neoplasms-follow-Neoplasms', 'Breast Neoplasms-follow-Neoplasms', 'Lymphoma-follow-Neoplasms', 'Stomach Neoplasms-follow-Lung Neoplasms', 'Head and Neck Neoplasms-associated-Carotid Stenosis', 'Carotid Stenosis-associated-Head and Neck Neoplasms', 'Breast Neoplasms-follow-Lung Neoplasms', 'Lymphoma-follow-Lung Neoplasms', 'Arthritis, Rheumatoid-become-Neoplasms', 'Acromegaly-evaluated-Death', 'Neoplasms-predict-Neoplasm Metastasis', 'Prostatic Neoplasms-predict-Neoplasm Metastasis', 'Neoplasms-become-Hemophilia A', 'Death-receive-Bradycardia', 'Death-diminish-Spinal Cord Injuries', 'Arthritis, Rheumatoid-defined-IgA Vasculitis', 'Stomach Ulcer-detect-Neoplasms', 'Death-show-Cardiovascular Diseases', 'Death-initiate-Ocular Hypertension', 'Ocular Hypertension-decide-Glaucoma', 'Lung Neoplasms-include-Pericardial Effusion', 'Breast Neoplasms-include-Pericardial Effusion', 'Neoplasms-include-Pericardial Effusion', 'Pericardial Effusion-present-Neoplasms', 'Death-contribute-Lung Neoplasms', 'Death-contribute-Coronary Artery Disease', 'Nephritis, Interstitial-include-Lung Diseases', 'Hamman-Rich Syndrome-include-Lung Diseases', 'Lung Diseases-complicate-Rheumatic Diseases', 'Death-involve-Gastric Outlet Obstruction', 'Pneumonia-include-Rheumatic Diseases', 'Nephritis, Interstitial-include-Rheumatic Diseases', 'Hamman-Rich Syndrome-include-Rheumatic Diseases', 'Renal Insufficiency-prevent-Anemia, Sickle Cell', 'Erectile Dysfunction-prevent-Anemia, Sickle Cell', 'Venous Thrombosis-gained-Ovarian Neoplasms', 'Arthritis, Rheumatoid-monitored-Infections', 'Arthritis, Rheumatoid-monitored-Kidney Diseases', 'Neoplasms-offer-Breast Neoplasms', 'Death-accounted-Acquired Immunodeficiency Syndrome', 'Rupture-lead-Hematoma', 'Sepsis-reflect-Death', 'Rheumatic Heart Disease-change-Endocarditis', 'Death-exclude-Stillbirth', 'Arthritis-characterized-Back Pain', 'Arthritis-characterized-Pain', 'Muscular Dystrophy, Duchenne-manage-Respiratory Insufficiency', 'Neoplasms-lost-HIV Infections', 'Lung Neoplasms-decrease-End Stage Liver Disease', 'Neuroendocrine Tumors-correlate-Death', 'Death-correlate-Neoplasms', 'Hypertension, Pulmonary-complicate-Lung Diseases', 'Hypertension, Pulmonary-complicate-Idiopathic Pulmonary Fibrosis', 'Hypertension, Pulmonary-complicate-Alveolitis, Extrinsic Allergic', 'Hypertension, Pulmonary-complicate-Lung Diseases, Interstitial', 'Alveolitis, Extrinsic Allergic-include-Lung Diseases', 'Metabolic Syndrome-characterize-Diabetes Mellitus', 'Diabetes Mellitus-characterize-Polycystic Ovary Syndrome', 'Obesity-compare-Heart Diseases', 'HIV Infections-affected-Hepatitis, Viral, Human', 'HIV Infections-identified-Chemical and Drug Induced Liver Injury', 'Sarcopenia-established-End Stage Liver Disease', 'Urethral Neoplasms-enrolled-Neoplasms', 'Acquired Immunodeficiency Syndrome-become-HIV Infections', 'Acquired Immunodeficiency Syndrome-become-Chronic Disease', 'Disease Progression-develop-Death', 'Infections-cause-Chagas Disease', 'Infections-lead-Cardiomyopathies', 'Chagas Disease-lead-Infections', 'Chagas Disease-lead-Cardiomyopathies', 'Chagas Disease-lead-Death', 'Hepatitis B-believed-Carcinoma, Hepatocellular', 'Cardiomyopathies-lead-Death', 'Metabolic Syndrome-induced-Chagas Disease', 'Lysosomal Storage Diseases-caused-Immunologic Deficiency Syndromes', 'Neoplasms-compare-Skin Neoplasms', 'Telangiectasia, Hereditary Hemorrhagic-associated-Death', 'Death-associated-Telangiectasia, Hereditary Hemorrhagic', 'Hepatitis C-related-Fibrosis', 'Skin Neoplasms-present-Crohn Disease', 'Mucopolysaccharidosis I-show-Coxa Valga', 'Obesity-combined-Osteoarthritis', 'Epilepsy-become-Seizures', 'Death-increase-Epilepsy, Temporal Lobe', 'Spinocerebellar Ataxias-present-Ataxia', 'Epilepsy, Temporal Lobe-become-Seizures', 'Melanosis-consist-Central Nervous System Neoplasms', 'Congenital Abnormalities-consist-Central Nervous System Neoplasms', 'Epilepsies, Partial-reported-Lung Diseases', 'Cough-occur-Fever', 'Weight Loss-occur-Fever', 'Chronic Disease-account-HIV Infections', 'Death-account-HIV Infections', 'Hepatitis C-avoid-Death', 'Renal Insufficiency-tend-Atherosclerosis', 'Renal Insufficiency-suffer-Atherosclerosis', 'Glioblastoma-use-Neurodegenerative Diseases', 'Kidney Diseases-associated-Peripheral Arterial Disease', 'Peripheral Arterial Disease-associated-Kidney Diseases', 'Breast Neoplasms-influence-Neoplasms', 'Mycoses-related-Acquired Immunodeficiency Syndrome', 'Marfan Syndrome-undergo-Aortic Aneurysm', 'Aortic Aneurysm-associated-Marfan Syndrome', 'Marfan Syndrome-associated-Aortic Aneurysm', 'Cardiovascular Diseases-associated-Marfan Syndrome', 'Marfan Syndrome-associated-Cardiovascular Diseases', 'Death-imply-Aneurysm', 'Hepatitis C-live-HIV Infections', 'Diabetes Mellitus-coexist-Cardiomyopathy, Hypertrophic', 'Neoplasms-assumed-Death', 'Silicosis-include-Pneumoconiosis', 'Gastroparesis-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-Gastroparesis', 'Osteoporosis-identified-Scoliosis', 'Communicable Diseases-estimate-Osteoarthritis', 'Fractures, Bone-assessed-Cerebral Palsy', 'Fractures, Bone-sustain-Cerebral Palsy', 'Dementia-progress-Heart Failure', 'Dementia-progress-Pulmonary Disease, Chronic Obstructive', 'Cystic Fibrosis-continue-Lung Diseases', 'Diabetic Nephropathies-affect-Diabetes Mellitus, Type 2', 'Diabetic Nephropathies-encountered-Diabetic Neuropathies', 'Diabetic Nephropathies-encountered-Diabetes Mellitus', 'Diabetic Nephropathies-affect-Erectile Dysfunction', 'Retinal Diseases-affect-Diabetes Mellitus, Type 2', 'Retinal Diseases-encountered-Diabetic Neuropathies', 'Retinal Diseases-encountered-Diabetes Mellitus', 'Retinal Diseases-affect-Erectile Dysfunction', 'Diabetes Mellitus, Type 2-encountered-Diabetic Neuropathies', 'Erectile Dysfunction-range-Diabetes Mellitus', 'HIV Infections-live-Lung Diseases', 'HIV Infections-reflect-Lung Diseases', 'Neoplasms-examine-Paralysis', 'Stroke-remain-Obesity', 'Stroke-experience-Hemorrhage', 'Peripheral Arterial Disease-yield-Stroke', 'Peripheral Arterial Disease-yield-Hemorrhage', 'Neoplasms-omitted-Breast Neoplasms', 'Pain-accelerate-Osteoarthritis', 'Neoplasms-reduce-Fatigue', 'Diabetes Mellitus-consist-Myocardial Infarction', 'Diabetes Mellitus-taken-Myocardial Infarction', 'Diabetes Mellitus-consist-Stroke', 'Diabetes Mellitus-taken-Stroke', 'Diabetes Mellitus-consist-Heart Failure', 'Diabetes Mellitus-taken-Heart Failure', 'Diabetes Mellitus-consist-Renal Insufficiency', 'Diabetes Mellitus-taken-Renal Insufficiency', 'Death-change-Myocardial Infarction', 'Myocardial Infarction-change-Heart Failure', 'Myocardial Infarction-change-Renal Insufficiency', 'Superior Vena Cava Syndrome-last-Death', 'Idiopathic Pulmonary Fibrosis-diagnosed-Lung Diseases', 'Heart Failure-mirror-Neoplasms', 'Ischemia-connected-Death', 'Common Cold-connected-Death', 'Urinary Bladder Neoplasms-compare-Death', 'Urinary Bladder Neoplasms-compare-Neoplasms', 'Neoplasms-exceed-Leukemia', 'Neoplasms-delay-Death', 'Death-caused-Melanoma', 'Melanoma-display-Neoplasms', 'Aortic Coarctation-grown-Heart Diseases', 'Wolfram Syndrome-present-Diabetes Mellitus, Type 1', 'Liver Cirrhosis-occur-Cystic Fibrosis', 'Cystic Fibrosis-occur-Liver Cirrhosis', 'Nasal Obstruction-noted-Hypertrophy', 'Dysplastic Nevus Syndrome-followed-Neoplasms', 'Dysplastic Nevus Syndrome-develop-Neoplasms', 'Barrett Esophagus-followed-Neoplasms', 'Barrett Esophagus-develop-Neoplasms', 'Uterine Hemorrhage-presented-Neoplasms', 'Osteosarcoma-distinguished-Carcinosarcoma', 'Neoplasms-distinguished-Carcinosarcoma', 'Thrombosis-regarded-Death', 'Hypertension, Pulmonary-regarded-Death', 'Pulmonary Heart Disease-regarded-Death', 'Lung Diseases-play-Hypertension, Pulmonary', 'Death-related-Melanoma', 'Diabetes Mellitus-reduce-Hypertension', 'Glucose Intolerance-classified-Diabetes Mellitus', 'Glucose Intolerance-classified-Myotonic Dystrophy', 'Cystic Fibrosis-classified-Diabetes Mellitus', 'Cystic Fibrosis-classified-Myotonic Dystrophy', 'Pancreatitis, Chronic-complicated-Abdominal Pain', 'Pancreatitis, Chronic-complicated-Pancreatitis', 'Pancreatitis, Chronic-complicated-Malnutrition', 'Dysmenorrhea-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-Dysmenorrhea', 'Dysmenorrhea-associated-Chronic Kidney Disease-Mineral and Bone Disorder', 'Chronic Kidney Disease-Mineral and Bone Disorder-associated-Dysmenorrhea', 'Alzheimer Disease-assess-Death', 'Lung Diseases-attributed-Colorectal Neoplasms', 'Lung Diseases-attributed-Lung Neoplasms', 'Colorectal Neoplasms-attributed-Lung Neoplasms', 'Communicable Diseases-tend-Death', 'Death-reverse-Diabetes Mellitus', 'Ovarian Diseases-alleviate-Primary Ovarian Insufficiency', 'Hemangiosarcoma-represent-Vascular Neoplasms', 'Diabetes Mellitus-screen-Metabolic Diseases', 'Infections-include-Opportunistic Infections', 'Infections-experience-Opportunistic Infections', 'Infections-include-Acquired Immunodeficiency Syndrome', 'Infections-experience-Acquired Immunodeficiency Syndrome', 'Obesity-simulate-Kidney Diseases', 'Obesity-simulate-Death', 'Renal Insufficiency, Chronic-simulate-Kidney Diseases', 'Renal Insufficiency, Chronic-simulate-Death', 'Arthritis, Rheumatoid-characterized-Synovitis', 'Autoimmune Diseases-characterized-Synovitis', 'Kidney Diseases-manifest-Kidney Failure, Chronic', 'Kidney Diseases-conduct-Death', 'Kidney Diseases-conduct-Kidney Failure, Chronic', 'Obesity-assigned-Diabetes Mellitus', 'Urethral Diseases-report-Erectile Dysfunction', 'Diabetes Mellitus-used-Diabetes Mellitus, Type 2', 'Neoplasm Metastasis-control-Neoplasms, Multiple Primary', 'Dyspnea-vary-Pulmonary Disease, Chronic Obstructive', 'Colorectal Neoplasms-deliver-Neoplasms', 'Gait Disorders, Neurologic-associated-Sarcopenia', 'Sarcopenia-associated-Gait Disorders, Neurologic', 'Death-exclude-Heart Diseases', 'Heart Diseases-exclude-Heart Failure', 'Heart Diseases-exclude-Cardiomyopathies', 'Heart Diseases-exclude-Atrial Fibrillation', 'Urolithiasis-associated-Fractures, Bone', 'Fractures, Bone-associated-Urolithiasis', 'Neoplasms-recognized-Venous Thromboembolism', 'Urolithiasis-remain-Fractures, Bone', 'Neoplasms-follow-Neoplasm Metastasis', 'Hyperphosphatemia-treat-Renal Insufficiency, Chronic', 'Death-avoid-Cachexia', 'Critical Illness-emerge-Hemorrhage', 'Critical Illness-result-Liver Failure', 'Hemorrhage-maintain-Liver Failure', 'Ovarian Neoplasms-report-Pelvic Pain', 'Colorectal Neoplasms-vary-Neoplasms', 'Neoplasm Metastasis-detect-Lung Neoplasms', 'Hepatitis C-reduce-Fibrosis', 'Hepatitis C, Chronic-infect-Infections', 'Neoplasms-conferred-Kidney Failure, Chronic', 'Arthritis, Rheumatoid-characterized-Inflammation', 'Colorectal Neoplasms-compete-Death', 'Psychoses, Substance-Induced-associated-Pain', 'Pain-associated-Psychoses, Substance-Induced', 'Psychoses, Substance-Induced-done-Pain', 'Lung Neoplasms-lead-Neoplasms', 'Pain-improve-Drug-Related Side Effects and Adverse Reactions', 'Death-affect-Prostatic Neoplasms', 'Prostatic Neoplasms-reside-Arthritis, Rheumatoid', 'Diabetes Mellitus-vary-Chronic Disease', 'Gastroesophageal Reflux-linked-Adenocarcinoma', 'Death-published-Communicable Diseases', 'Atrophy-delineate-Parkinson Disease', 'Neurodegenerative Diseases-delineate-Parkinson Disease', 'Parkinsonian Disorders-delineate-Parkinson Disease', 'Multiple Sclerosis-followed-Death', 'Cystic Fibrosis-associated-Colorectal Neoplasms', 'Colorectal Neoplasms-associated-Cystic Fibrosis', 'Cystic Fibrosis-address-Digestive System Neoplasms', 'Colorectal Neoplasms-compare-Cystic Fibrosis', 'Neoplasms-incur-Uterine Cervical Neoplasms', 'Diabetes Mellitus-capture-Hypoglycemia', 'Cystic Fibrosis-prevent-Death', 'Cystic Fibrosis-prevent-Colorectal Neoplasms', 'Neoplasms-estimate-Urinary Bladder Neoplasms', 'Death-employed-Adrenal Insufficiency', 'Urinary Incontinence-observed-Alzheimer Disease', 'Death-studied-Adrenal Insufficiency', 'Death-experience-Multiple Organ Failure', 'Heart Diseases-evaluate-Infarction', 'Vulvar Neoplasms-selected-Neoplasms', 'Ovarian Diseases-range-Polycystic Ovary Syndrome', 'Polycystic Ovary Syndrome-range-Hyperandrogenism', 'Carcinoma, Hepatocellular-distinguish-Cholangiocarcinoma', 'Cholangiocarcinoma-relate-Carcinoma, Hepatocellular', 'Death-associated-Invasive Fungal Infections', 'Invasive Fungal Infections-associated-Death', 'Coronary Artery Disease-estimated-Myocardial Infarction', 'Coronary Artery Disease-estimated-Angina Pectoris', 'Neoplasms-treated-Cardiotoxicity', 'Coronary Artery Disease-estimated-Heart Failure', 'Ventricular Dysfunction-reduce-Heart Failure', 'Ventricular Dysfunction-reduce-Neoplasms', 'Weight Loss-suffer-Parkinson Disease', 'Fractures, Open-prevent-Fractures, Bone', 'Lip Neoplasms-pooled-Head and Neck Neoplasms', 'Parkinson Disease-study-Tremor', 'Parkinson Disease-study-Dyskinesia, Drug-Induced', 'Parkinson Disease-study-Dementia', 'Parkinson Disease-study-Fever', 'Parkinson Disease-study-Infections', 'Parkinson Disease-study-Thyroid Diseases', 'Parkinson Disease-study-Deglutition Disorders', 'Ischemia-receive-Kidney Diseases', 'Cerebral Infarction-prevent-Atrial Fibrillation', 'Gastric Outlet Obstruction-palliate-Weight Loss', 'Gastric Outlet Obstruction-palliate-Anorexia', 'Coronary Artery Disease-captured-Metabolic Syndrome', 'Neoplasms-use-Neoplasm Metastasis', 'Neoplasms-undergo-Neoplasm Metastasis', 'Osteoporosis-associated-Cystic Fibrosis', 'Cystic Fibrosis-associated-Osteoporosis', 'Neoplasms-associate-Adenoma', 'Adenoma-associate-Neoplasms', 'Dementia, Vascular-share-Stroke', 'Pelvic Inflammatory Disease-acquire-Infertility, Female', 'Pelvic Inflammatory Disease-acquire-Pelvic Pain', 'Hypertension-identify-Hemorrhage', 'Fibrosis-complicated-Hypertension, Pulmonary', 'Fibrosis-admitted-Hypertension, Pulmonary', 'Death-associated-Epilepsy, Benign Neonatal', 'Epilepsy, Benign Neonatal-associated-Death', 'Death-include-Epilepsy, Benign Neonatal', 'Death-assist-Aneurysm', 'Cardiovascular Diseases-estimate-Death', 'Cardiovascular Diseases-estimate-Coronary Artery Disease', 'Cardiovascular Diseases-estimate-Stroke', 'Death-avoid-Postphlebitic Syndrome', 'Thalassemia-experience-Pain', 'Muscular Dystrophy, Duchenne-alleviate-Back Pain', 'Muscular Dystrophy, Duchenne-alleviate-Thalassemia', 'Muscular Dystrophy, Duchenne-alleviate-Osteoporosis', 'Pain-associated-Musculoskeletal Pain', 'Musculoskeletal Pain-associated-Pain', 'Back Pain-alleviate-Thalassemia', 'Back Pain-alleviate-Osteoporosis', 'Aortic Arch Syndromes-include-Heart Diseases', 'Infections-track-Drug Overdose', 'Infections-track-Death', 'Drug Overdose-track-Death', 'Drug Overdose-track-Bradycardia', 'Death-track-Bradycardia', 'Pain-increase-Sarcopenia', 'Weight Gain-lead-Back Pain', 'Carcinoma, Squamous Cell-recur-Neoplasms', 'Dementia-followed-Dementia, Vascular', 'Infarction-study-Heart Failure', 'Cystic Fibrosis-affect-Infections', 'Genetic Diseases, Inborn-affect-Infections', 'Neurodegenerative Diseases-compare-Glaucoma, Open-Angle', 'Neurodegenerative Diseases-compare-Glaucoma', 'Heart Failure-obtain-Weight Loss', 'Neoplasm Metastasis-increase-Neoplasms', 'Death-reflect-Diabetes Mellitus', 'Diabetic Nephropathies-increase-Diabetes Mellitus', 'Neoplasms-occur-Carcinoma, Hepatocellular', 'Carcinoma, Hepatocellular-occur-Neoplasms', 'Death-receive-Aortic Diseases', 'Death-performed-Aneurysm', 'Coronary Artery Disease-occur-Death', 'Stroke-shown-Carotid Stenosis', 'Death-treat-Carotid Stenosis', 'Insulinoma-combined-Neoplasm Metastasis', 'Death-experience-Skin Neoplasms', 'Diabetes Mellitus-encounter-Death', 'Diabetes Mellitus, Type 2-suffer-Polycystic Ovary Syndrome', 'Malnutrition-malnourished-Dementia', 'Shock, Septic-carry-Death', 'Cystic Fibrosis-develop-Liver Diseases', 'Non-alcoholic Fatty Liver Disease-recognized-Metabolic Syndrome', 'Diabetes Mellitus-comprise-Death', 'Death-found-Arterial Occlusive Diseases', 'Death-comprise-Neoplasms', 'Death-comprise-Carcinogenesis', 'Trachoma-noth-Trichiasis', 'Trachoma-noth-Vision, Low', 'Trachoma-noth-Blindness', 'Aortic Aneurysm, Abdominal-balanced-Rupture', 'Neoplasms-shown-Hypoxia', 'Hypoxia-used-Neoplasms', 'Hemochromatosis-occur-Porphyria Cutanea Tarda', 'Lung Diseases-complete-Tuberculosis, Multidrug-Resistant', 'Hyperlipidemias-identify-Diabetes Mellitus', 'Hyperlipidemias-treat-Diabetes Mellitus', 'Hyperlipidemias-treat-Cardiovascular Diseases', 'Hyperlipidemias-identify-Cardiovascular Diseases', 'Pulmonary Disease, Chronic Obstructive-need-Respiratory Insufficiency', 'Death-examine-Diabetes Mellitus', 'Gallstones-consider-Pain', 'Gallstones-consider-Cholecystitis', 'Gallstones-consider-Pancreatitis', 'Gallstones-consider-Gallbladder Neoplasms', 'Cholecystitis-include-Pain', 'Pancreatitis-include-Pain', 'Gallbladder Neoplasms-include-Pain', 'Kidney Diseases-indicated-Diabetes Mellitus, Type 1', 'Gallstones-recur-Pain', 'Lung Neoplasms-elucidate-Neoplasms', 'Fatigue Syndrome, Chronic-characterised-Fatigue', 'Fatigue Syndrome, Chronic-characterised-Sleep Wake Disorders', 'Disease-characterised-Fatigue', 'Disease-characterised-Sleep Wake Disorders', 'Alzheimer Disease-considered-Diabetes Mellitus', 'Acquired Immunodeficiency Syndrome-use-HIV Infections', 'Acquired Immunodeficiency Syndrome-avert-HIV Infections', 'Acquired Immunodeficiency Syndrome-use-Sleep Initiation and Maintenance Disorders', 'Acquired Immunodeficiency Syndrome-estimate-Sleep Initiation and Maintenance Disorders', 'Acquired Immunodeficiency Syndrome-use-Infections', 'Acquired Immunodeficiency Syndrome-estimate-Infections', 'HIV Infections-apply-Sleep Initiation and Maintenance Disorders', 'HIV Infections-avert-Infections', 'Coronary Artery Disease-decelerate-Death', 'Stroke-decelerate-Death', 'Opioid-Related Disorders-screen-Sleep Wake Disorders', 'Opioid-Related Disorders-screen-Chronic Pain', 'Opioid-Related Disorders-precede-Sleep Wake Disorders', 'Opioid-Related Disorders-assess-Sleep Wake Disorders', 'Opioid-Related Disorders-assess-Chronic Pain', 'Knee Injuries-understand-Osteoarthritis', 'Atypical Hemolytic Uremic Syndrome-lead-Kidney Diseases', 'Atypical Hemolytic Uremic Syndrome-lead-Death', 'Pain-administered-Spinal Cord Injuries', 'Osteoarthritis-remain-Neurodegenerative Diseases', 'Pain-confirmed-Spinal Cord Injuries', 'Dementia-follow-Death', 'Alcoholism-affect-Death', 'Obesity-decline-Death', 'Obesity-estimate-Death', 'Cystic Fibrosis-register-Genetic Diseases, Inborn', 'Cardiovascular Abnormalities-prevent-Cardiomyopathies', 'HIV Infections-present-Peripheral Nervous System Diseases', 'Urethral Neoplasms-overexpressing-Neoplasms', 'Cardiovascular Diseases-divided-HIV Infections', 'Cardiovascular Diseases-divided-Metabolic Syndrome', 'Neoplasms-link-Death', 'Tricuspid Valve Insufficiency-associate-Atrial Fibrillation', 'Atrial Fibrillation-associate-Tricuspid Valve Insufficiency', 'Tricuspid Valve Insufficiency-associate-Heart Failure', 'Heart Failure-associate-Tricuspid Valve Insufficiency', 'Tricuspid Valve Insufficiency-associate-Heart Defects, Congenital', 'Heart Defects, Congenital-associate-Tricuspid Valve Insufficiency', 'Cystic Fibrosis-exhibit-Osteoma, Osteoid', 'Cystic Fibrosis-exhibit-Diabetes Mellitus', 'Cough-couple-Fractures, Bone', 'Emphysema-Combined-Idiopathic Pulmonary Fibrosis', 'Idiopathic Pulmonary Fibrosis-compare-Emphysema', 'Uterine Cervical Neoplasms-explain-Papillomavirus Infections', 'Uterine Cervical Neoplasms-explain-Infections', 'Arthritis, Rheumatoid-matched-Neoplasms', 'Arthritis, Rheumatoid-matched-Death', 'Arthritis, Rheumatoid-diagnosed-Neoplasms', 'Colorectal Neoplasms-diagnosed-Colorectal Neoplasms, Hereditary Nonpolyposis', 'Death-comprise-Diabetes Mellitus', 'Glaucoma-progress-Blindness', 'Death, Sudden, Cardiac-indicated-Ischemia', 'Death, Sudden, Cardiac-indicated-Cardiomyopathy, Dilated', 'Cystic Fibrosis-characterized-Pneumonia', 'Renal Insufficiency, Chronic-refer-Arteriovenous Fistula', 'Pneumoconiosis-recruited-Occupational Diseases', 'Pneumoconiosis-recruited-Death', 'Scoliosis-control-Marfan Syndrome', 'Papillomavirus Infections-shown-Uterine Cervical Neoplasms', 'Neoplasms-identify-Carcinoma, Hepatocellular', 'Marfan Syndrome-become-Spinal Diseases', 'Neoplasms-plagued-Death', 'Neoplasms-plagued-Pain', 'Death-plagued-Pain', 'Obesity-estimate-Cardiovascular Diseases', 'Obesity-estimate-Diabetes Mellitus', 'Gastrointestinal Diseases-project-Arthritis, Rheumatoid', 'Myocardial Infarction-project-Arthritis, Rheumatoid', 'Hip Fractures-take-Fractures, Bone', 'Cushing Syndrome-performed-Death', 'Glioma-represent-Death', 'Glioma-represent-Neoplasms', 'Carotid Stenosis-base-Carotid Artery Diseases', 'Neoplasm Metastasis-prevent-Nervous System Diseases', 'Atrial Fibrillation-encouraged-Mitral Valve Stenosis', 'Atrial Fibrillation-treated-Mitral Valve Stenosis', 'Atrial Fibrillation-encouraged-Stroke', 'Atrial Fibrillation-avert-Stroke', 'Mitral Valve Stenosis-avert-Stroke', 'Atrial Fibrillation-detect-Mitral Valve Stenosis', 'Heart Defects, Congenital-characterized-Atrioventricular Block', 'Hearing Loss-treat-Neurodegenerative Diseases', 'Coronavirus Infections-result-Death', 'Neurodegenerative Diseases-occur-Infarction', 'Dysbiosis-associated-Hypertension', 'Hypertension-associated-Dysbiosis', 'Renal Insufficiency-lead-Weight Loss', 'Central Nervous System Diseases-characterized-Demyelinating Diseases', 'Osteoarthritis-associated-Weight Gain', 'Weight Gain-associated-Osteoarthritis', 'Anemia-associated-Telangiectasia, Hereditary Hemorrhagic', 'Telangiectasia, Hereditary Hemorrhagic-associated-Anemia', 'Carotid Artery Injuries-trigger-Thrombosis', 'Diabetes Mellitus-integrated-Prediabetic State', 'Diabetes Mellitus-integrated-Obesity', 'Tourette Syndrome-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-Tourette Syndrome', 'Tic Disorders-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-Tic Disorders', 'Coronary Artery Disease-include-Dyslipidemias', 'Arrhythmias, Cardiac-include-Dyslipidemias', 'Cerebrovascular Disorders-include-Dyslipidemias', 'Ischemia-include-Dyslipidemias', 'Arteriosclerosis-include-Dyslipidemias', 'Cerebrovascular Disorders-include-Hypertension', 'Arteriosclerosis-include-Hypertension', 'Arrhythmias, Cardiac-include-Diabetes Mellitus', 'Cerebrovascular Disorders-include-Diabetes Mellitus', 'Arteriosclerosis-include-Diabetes Mellitus', 'Breast Neoplasms-undergo-Death', 'Death-consider-Neoplasms', 'Pancreatic Neoplasms-diagnosed-Neoplasms', 'Acromegaly-exhibit-Diabetes Mellitus', 'Acromegaly-exhibit-Hypertension', 'Acromegaly-exhibit-Cardiovascular Diseases', 'Death-project-Lymphoma', 'Lymphoma-project-Neoplasms', 'Coronary Artery Disease-stratify-Diabetes Mellitus', 'Death-vary-Diabetes Mellitus', 'Anemia-found-Acquired Immunodeficiency Syndrome', 'Fibrosis-reduce-Carcinoma, Hepatocellular', 'Coronary Artery Disease-present-Chest Pain', 'Spinal Cord Injuries-result-Gait Disorders, Neurologic', 'Death-maintain-Chronic Disease', 'Death-result-Parasitic Diseases', 'Prostatic Neoplasms-use-Death', 'Infections-associated-Kidney Failure, Chronic', 'Kidney Failure, Chronic-associated-Infections', 'Death-related-Chemical and Drug Induced Liver Injury', 'Death-considered-Prostatic Neoplasms', 'Dementia-influence-Death', 'Ureteral Diseases-drained-Cutaneous Fistula', 'Ureteral Diseases-proposed-Cutaneous Fistula', 'Sepsis-develop-Critical Illness', 'Respiratory Distress Syndrome-develop-Critical Illness', 'Death-develop-Critical Illness', 'Death-appear-Brain Diseases', 'Graft vs Host Disease-appear-Brain Diseases', 'Fractures, Bone-reported-Lupus Erythematosus, Systemic', 'Lupus Erythematosus, Systemic-compare-Fractures, Bone', 'Fractures, Bone-occur-Lupus Erythematosus, Systemic', 'Fractures, Bone-ascertained-Lupus Erythematosus, Systemic', 'Cardiomyopathy, Hypertrophic-cause-Death', 'Death-related-Cardiomyopathy, Hypertrophic', 'Superior Vena Cava Syndrome-combine-Neoplasms', 'HIV Infections-impact-Death', 'Acquired Immunodeficiency Syndrome-impact-Death', 'Death-exceed-Shock', 'Gastroesophageal Reflux-characterized-Chest Pain', 'Sialorrhea-decreased-Cough', 'Sialorrhea-result-Respiratory Tract Infections', 'Cough-result-Respiratory Tract Infections', 'Otosclerosis-cause-Hearing Loss', 'Ear Diseases-cause-Hearing Loss', 'Drug-Related Side Effects and Adverse Reactions-increase-Osteosarcoma', 'Parkinson Disease-conduct-Weight Loss', 'Stroke-reduce-Periodontitis', 'Fractures, Bone-verify-Wounds and Injuries', 'Multiple Myeloma-develop-Fractures, Bone', 'Gynecomastia-exclude-Breast Neoplasms', 'Gynecomastia-distinguish-Breast Neoplasms', 'Peutz-Jeghers Syndrome-defined-Hamartoma', 'Colorectal Neoplasms, Hereditary Nonpolyposis-defined-Hamartoma', 'Obesity-associated-Periprosthetic Fractures', 'Periprosthetic Fractures-associated-Obesity', 'Hypertension-associated-Periprosthetic Fractures', 'Periprosthetic Fractures-associated-Hypertension', 'Anemia, Iron-Deficiency-associated-Periprosthetic Fractures', 'Periprosthetic Fractures-associated-Anemia, Iron-Deficiency', 'Diabetes Mellitus-buil-Leukemia, Lymphocytic, Chronic, B-Cell', 'Hemophilia A-associated-Joint Diseases', 'Joint Diseases-associated-Hemophilia A', 'Hemophilia A-associated-Intracranial Hemorrhages', 'Intracranial Hemorrhages-associated-Hemophilia A', 'Blood Coagulation Disorders, Inherited-associated-Joint Diseases', 'Joint Diseases-associated-Blood Coagulation Disorders, Inherited', 'Blood Coagulation Disorders, Inherited-associated-Intracranial Hemorrhages', 'Intracranial Hemorrhages-associated-Blood Coagulation Disorders, Inherited', 'Death-contribute-Sialic Acid Storage Disease', 'Cerebrospinal Fluid Rhinorrhea-include-Death', 'Phenylketonurias-followed-Arrhythmias, Cardiac', 'Diabetes Mellitus, Type 2-involve-Weight Loss', 'Diabetes Mellitus, Type 2-promote-Weight Loss', 'Diabetes Mellitus, Type 2-involve-Hypoglycemia', 'Parkinson Disease-reduce-Parkinsonian Disorders', 'HIV Infections-develop-Parkinson Disease, Secondary', 'Parkinson Disease, Secondary-develop-Neurodegenerative Diseases', 'Neoplasms-result-Colorectal Neoplasms', 'Ulcer-reported-Movement Disorders', 'Colorectal Neoplasms-kept-Neoplasms, Second Primary', 'Alcoholism-develop-Memory Disorders', 'Pancreatic Neoplasms-remain-Neoplasms', 'Pancreatic Neoplasms-remain-Death', 'Arrhythmias, Cardiac-found-Muscular Diseases', 'Muscular Diseases-carry-Arrhythmias, Cardiac', 'Lung Neoplasms-recommend-Colorectal Neoplasms', 'Hepatitis B, Chronic-develop-Liver Diseases', 'Cardiac Output, Low-occur-Acute Kidney Injury', 'Heart Failure-see-Death', 'Prostatic Neoplasms-registered-Neoplasms', 'Prostatic Neoplasms-account-Neoplasms', 'Thyroid Neoplasms-develop-Neoplasms', 'Neoplasms-revolutionize-Melanoma', 'Aortic Aneurysm, Abdominal-screen-Death', 'Hypertension-include-Hyperglycemia', 'Hypertension-include-Hyperlipidemias', 'Hypertension-include-Hyperuricemia', 'Phenylketonurias-prevent-Intellectual Disability', 'Lymphoproliferative Disorders-treated-Splenomegaly', 'Lymphoproliferative Disorders-treated-Pain', 'Myeloproliferative Disorders-treated-Splenomegaly', 'Myeloproliferative Disorders-treated-Pain', 'Lymphoma, Non-Hodgkin-included-Retinal Necrosis Syndrome, Acute', 'Pleural Effusion-collected-Lung Neoplasms', 'Pleural Effusion-collected-Heart Failure', 'Pain-suffer-Fatigue', 'Pain-suffer-Sleep Initiation and Maintenance Disorders', 'Cardiomyopathy, Hypertrophic-characterized-Cardiomegaly', 'Cystic Fibrosis-diagnosed-Neoplasms', 'Multiple Sclerosis-predispose-Hip Fractures', 'Multiple Sclerosis-affect-Osteoarthritis', 'Communicable Diseases-predispose-Hip Fractures', 'Communicable Diseases-affect-Osteoarthritis', 'Neoplasms-undergo-Inflammatory Bowel Diseases', 'Asthma-rely-Death', 'Chronic Disease-received-Dementia', 'Brain Neoplasms-diagnosed-Glioblastoma', 'Brain Diseases, Metabolic-attenuate-Cachexia', 'HIV Infections-emerge-Cardiovascular Diseases', 'Obesity-increase-Pain', 'Fibrosis-reduce-Death', 'Hereditary Angioedema Type III-impact-Urinary Bladder, Overactive', 'Death-observed-Acromegaly', 'Acromegaly-compared-Death', 'HIV Infections-diagnosed-Death', 'Hematologic Diseases-lead-Death', 'Death-compare-Hyponatremia', 'Renal Insufficiency, Chronic-developed-Atherosclerosis', 'Renal Insufficiency, Chronic-developed-Stroke', 'Renal Insufficiency, Chronic-developed-Death', 'Cardiovascular Diseases-estimated-Renal Insufficiency, Chronic', 'Diabetic Foot-characterized-Death', 'Cardiovascular Diseases-characterized-Death', 'Neoplasms-increase-Stroke', 'Diabetic Foot-treated-Diabetes Mellitus', 'Hemorrhage-carry-Death', 'Death-coincide-Coronary Artery Disease', 'Hypertension-suffer-Hypercholesterolemia', 'Death-result-Syphilis', 'Sleep Apnea Syndromes-characterized-Sleep Wake Disorders', 'Sleep Apnea Syndromes-characterized-Obesity', 'Sleep Apnea Syndromes-characterized-Diabetes Mellitus, Type 2', 'Sleep Apnea Syndromes-characterized-Cardiovascular Diseases', 'Sleep Wake Disorders-characterized-Obesity', 'Sleep Wake Disorders-characterized-Diabetes Mellitus, Type 2', 'Sleep Wake Disorders-characterized-Cardiovascular Diseases', 'Epilepsy, Temporal Lobe-disable-Memory Disorders', 'Endocarditis-consider-Death', 'Death-related-Thyroid Neoplasms', 'Pancreatic Neoplasms-develop-Duodenal Obstruction', 'Pancreatitis-develop-Duodenal Obstruction', 'Duodenal Obstruction-require-Pancreatitis', 'Aicardi Syndrome-characterized-Chorioretinitis', 'Aicardi Syndrome-characterized-Spasms, Infantile', 'Diabetes Mellitus-incorporate-Cardiovascular Diseases', 'Diabetes Mellitus-incorporate-Kidney Failure, Chronic', 'Diabetes Mellitus-incorporate-Blindness', 'Hepatitis C-evaluate-Infections', 'Neoplasm Metastasis-cause-Death', 'Neoplasm Metastasis-cause-Prostatic Neoplasms', 'Adenocarcinoma-develop-Barrett Esophagus', 'Death-dispensed-Glaucoma', 'Fistula-caused-Neoplasms', 'Neoplasms-inserted-Deglutition Disorders', 'Neoplasms-inserted-Fistula', 'Heart Diseases-undergo-Tachycardia, Ventricular', 'Fabry Disease-improve-Pain', 'Ocular Hypertension-treat-Glaucoma', 'Fabry Disease-stabilize-Cardiomyopathies', 'Corneal Diseases-treat-Glaucoma', 'Pain-stabilize-Cardiomyopathies', 'Rupture-include-Cardiovascular Diseases', 'Heart Failure-respond-Kidney Tubular Necrosis, Acute', 'Diabetes Mellitus-treat-Insulin Resistance', 'Neoplasms-exclude-Death', 'Kidney Failure, Chronic-combined-Death', 'Metrorrhagia-considered-Polyps', 'Chemical and Drug Induced Liver Injury-result-Fibrosis', 'Death-elevated-Brain Injuries, Traumatic', 'Hepatitis C, Chronic-reduce-Fibrosis', 'Weight Loss-reduce-Hypercholesterolemia', 'Weight Loss-reduce-Coronary Artery Disease', 'Weight Loss-reduce-Stroke', 'Neoplasms-presented-Osteosarcoma', 'Neoplasms-presented-Fibrosarcoma', 'Neoplasms-presented-Carcinoma, Squamous Cell', 'Inflammation-cause-Diarrhea', 'Inflammation-cause-Rectal Diseases', 'Breast Neoplasms-arose-Cardiovascular Diseases', 'Cardiovascular Diseases-arose-Death', 'Dementia-outweigh-Neoplasms', 'Periodontitis-gain-HIV Infections', 'Pain-reverse-Multiple Organ Failure', 'Alzheimer Disease-distinguish-Atrophy', 'Pain-alter-Death', 'Multiple Organ Failure-alter-Death', 'Neoplasms-demonstrate-Dementia', 'Neoplasms-recorded-Death', 'HIV Infections-aged-Death', 'Anemia, Sickle Cell-characterised-Anemia', 'Stroke-detect-Cerebral Infarction', 'Thalassemia-detect-Cerebral Infarction', 'Wounds and Injuries-administered-Nervous System Diseases', 'Nervous System Diseases-perpetuate-Wounds and Injuries', 'Sleep Wake Disorders-represent-Obesity', 'Kidney Failure, Chronic-associated-Neoplasms', 'Neoplasms-associated-Kidney Failure, Chronic', 'Dementia-decrease-Death', 'Death-decrease-Dementia', 'Neoplasm Metastasis-achieve-Neoplasms', 'Hyperbilirubinemia-reverse-Liver Cirrhosis', 'Hyperbilirubinemia-reverse-Inflammation', 'Endometrial Hyperplasia-present-Menorrhagia', 'Carcinoma, Ovarian Epithelial-obtain-Neoplasms', 'Death-reduce-Poisoning', 'Jaw, Edentulous-associated-Death', 'Death-associated-Jaw, Edentulous', 'Infections-treat-Fever', 'Neoplasm Invasiveness-detected-Prostatic Neoplasms', 'Adenomatous Polyposis Coli-detected-Prostatic Neoplasms', 'Adenomatous Polyposis Coli-detected-Neoplasms', 'Hepatitis C, Chronic-prevent-Death', 'Hypertension, Pulmonary-associated-Lung Diseases', 'Lung Diseases-associated-Hypertension, Pulmonary', 'Thrombocytopenia-rule-Leukemia', 'Hepatitis B-result-Fibrosis', 'Viremia-result-Fibrosis', 'Infections-result-Liver Failure', 'Hepatitis B-result-Liver Failure', 'Hepatitis B-result-Death', 'Spinal Cord Injuries-impair-Gait Disorders, Neurologic', 'Wounds and Injuries-impair-Gait Disorders, Neurologic', 'Drug-Related Side Effects and Adverse Reactions-compromise-Neoplasms', 'Diabetes Mellitus-assess-Dementia', 'Neoplasm Metastasis-lose-Neoplasms', 'Neoplasms-screened-Prostatic Neoplasms', 'Renal Insufficiency-diagnosed-Prostatic Neoplasms', 'Dystonia-coexist-Diabetes Mellitus', 'Death-evaluate-Prostatic Neoplasms', 'Anemia, Sickle Cell-precede-Death', 'Facial Dermatoses-accompany-Fetal Alcohol Spectrum Disorders', 'Vision Disorders-suspected-Cerebrovascular Disorders', 'Diabetes Mellitus, Type 2-offer-Weight Loss', 'Diabetes Mellitus, Type 2-offer-Hypoglycemia', 'Cardiovascular Diseases-focus-Sleep Initiation and Maintenance Disorders', 'Psychoses, Substance-Induced-reduced-Cardiovascular Diseases', 'Diabetes Mellitus, Type 2-increase-Hypertension', 'Pain-given-Neoplasms', 'Arthritis, Rheumatoid-enrol-Cardiovascular Diseases', 'Anemia, Sickle Cell-prevent-Death', 'Carcinoma, Hepatocellular-lost-Neoplasms', 'Neoplasm Metastasis-associated-Pain', 'Pain-associated-Neoplasm Metastasis', 'Osteoarthritis-compared-Arthritis, Rheumatoid', 'Arthritis, Rheumatoid-compare-Pain', 'Arthritis, Rheumatoid-measured-Arthritis', 'Pleural Effusion, Malignant-complicate-Neoplasms', 'Osteoarthritis-measured-Arthritis', 'Pain-measured-Arthritis', 'Head and Neck Neoplasms-indicate-Carotid Stenosis', 'Obesity, Abdominal-associated-Venous Thrombosis', 'Venous Thrombosis-associated-Obesity, Abdominal', 'Nausea-used-Neoplasms', 'Nausea-predict-Neoplasms', 'Deglutition Disorders-used-Neoplasms', 'Deglutition Disorders-predict-Neoplasms', 'Dyspnea-used-Neoplasms', 'Dyspnea-predict-Neoplasms', 'Pulmonary Disease, Chronic Obstructive-undergo-Aortic Aneurysm, Abdominal', 'Obesity, Abdominal-modify-Venous Thrombosis', 'Diabetes Mellitus-block-Diabetic Nephropathies', 'Shock, Cardiogenic-collected-Myocardial Infarction', 'Thrombocytopenia-ameliorate-Purpura, Thrombocytopenic, Idiopathic', 'Carcinoma-associated-Death', 'Death-associated-Carcinoma', 'Death-receive-Arthritis, Rheumatoid', 'Polyneuropathies-compare-Amyloidosis', 'Glioblastoma-collect-Neoplasms', 'Neoplasms-cause-Wounds and Injuries', 'Wounds and Injuries-collect-Glioblastoma', 'Wounds and Injuries-collect-Neoplasms', 'Pain-relieved-Adrenal Insufficiency', 'Neoplasms-relieved-Adrenal Insufficiency', 'Brain Injuries, Traumatic-mediate-Pain', 'Head and Neck Neoplasms-describe-Neoplasms', 'Huntington Disease-compare-Renal Insufficiency', 'Renal Insufficiency-living-Huntington Disease', 'Chronic Disease-empower-Diabetes Mellitus', 'Chronic Disease-improve-Diabetes Mellitus', 'Hematologic Neoplasms-known-Leukemia', 'Ischemia-result-Stroke', 'Ischemia-result-Atrophy', 'Death-diagnosed-Carcinoma, Non-Small-Cell Lung', 'Stroke-result-Atrophy', 'Stroke-improve-Atrophy', 'Neoplasms-affected-Drug-Related Side Effects and Adverse Reactions', 'Ascites-originate-Prodromal Symptoms', 'Pleural Effusion-originate-Prodromal Symptoms', 'Thalassemia-suffer-Growth Disorders', 'Cerebral Palsy-confirm-Dyskinesia, Drug-Induced', 'Neoplasms-represent-Pain', 'Breast Neoplasms-shown-Doxorubicin', 'Takotsubo Cardiomyopathy-associated-Death', 'Death-associated-Takotsubo Cardiomyopathy', 'Breast Neoplasms-used-Neoplasms', 'Hemolysis-exist-Gilbert Disease', 'Hemolysis-serve-Hyperbilirubinemia', 'Gilbert Disease-serve-Hyperbilirubinemia', 'Death-select-Mitral Valve Insufficiency', 'Death-recommended-Tuberculosis', 'Neoplasms-used-Carcinoma, Non-Small-Cell Lung', 'Mitral Valve Insufficiency-result-Postoperative Complications', 'Primary Myelofibrosis-characterised-Splenomegaly', 'Osteonecrosis-lead-Hip Dislocation, Congenital', 'Primary Myelofibrosis-characterised-Hematologic Diseases', 'Primary Myelofibrosis-achieve-Drug-Related Side Effects and Adverse Reactions', 'Hip Dislocation, Congenital-lead-Precursor Cell Lymphoblastic Leukemia-Lymphoma', 'Primary Myelofibrosis-characterised-Fatigue', 'Primary Myelofibrosis-characterised-Weight Loss', 'Primary Myelofibrosis-characterised-Pain', 'Myeloproliferative Disorders-characterised-Splenomegaly', 'Myeloproliferative Disorders-characterised-Hematologic Diseases', 'Myeloproliferative Disorders-characterised-Primary Myelofibrosis', 'Myeloproliferative Disorders-characterised-Fatigue', 'Myeloproliferative Disorders-characterised-Weight Loss', 'Myeloproliferative Disorders-characterised-Pain', 'Pachyonychia Congenita-consent-Pain', 'Neuralgia-observed-Pachyonychia Congenita', 'Fractures, Bone-require-Bone Diseases', 'Death-occur-Acquired Immunodeficiency Syndrome', 'Epilepsy-yield-Drug Resistant Epilepsy', 'Colorectal Neoplasms-linked-Neoplasm Metastasis', 'Coronary Artery Disease-predicted-Hypertension', 'Coronary Artery Disease-predicted-Diabetes Mellitus', 'Coronary Artery Disease-predicted-Obesity', 'Hyperpigmentation-suggest-Addison Disease', 'Nausea-suggest-Addison Disease', 'Vomiting-suggest-Addison Disease', 'Weight Loss-suggest-Addison Disease', 'Meningococcal Infections-present-Meningitis', 'Meningococcal Infections-present-Sepsis', 'Acute Kidney Injury-accompanied-Multiple Organ Failure', 'Ophthalmoplegia-associated-Hemorrhage', 'Hemorrhage-associated-Ophthalmoplegia', 'Nystagmus, Pathologic-associated-Hemorrhage', 'Hemorrhage-associated-Nystagmus, Pathologic', 'Ataxia-associated-Hemorrhage', 'Hemorrhage-associated-Ataxia', 'Celiac Disease-result-Death', 'Aneurysm-repair-Subarachnoid Hemorrhage', 'Cystic Fibrosis-characterized-Airway Obstruction', 'Death-collected-Cerebral Palsy', 'Hereditary Breast and Ovarian Cancer Syndrome-characterized-Thyroid Neoplasms', 'Hereditary Breast and Ovarian Cancer Syndrome-characterized-Pheochromocytoma', 'Hereditary Breast and Ovarian Cancer Syndrome-characterized-Hyperparathyroidism', 'Gallstones-function-Dyskinesias', 'HIV Infections-become-Atherosclerosis', 'Adenoma-impact-Death', 'Non-alcoholic Fatty Liver Disease-compete-Death', 'Neoplasms-use-Carcinoma, Squamous Cell', 'Carcinoma, Squamous Cell-present-Pain', 'Carcinoma, Squamous Cell-present-Hemorrhage', 'Diabetes Mellitus-emerge-Chronic Disease', 'Death-decrease-Diabetes Mellitus', 'Arthritis, Rheumatoid-associated-Bone Diseases, Metabolic', 'Bone Diseases, Metabolic-associated-Arthritis, Rheumatoid', 'Death-cause-Cerebral Hemorrhage', 'Ventricular Dysfunction-associated-Death', 'Death-associated-Ventricular Dysfunction', 'Cerebral Hemorrhage-compared-Death', 'Cerebral Hemorrhage-cause-Death', 'Skin Neoplasms-treat-Fever', 'Skin Neoplasms-use-Fever', 'Neoplasms-recommend-Breast Neoplasms', 'Neuromuscular Diseases-associated-Death', 'Death-associated-Neuromuscular Diseases', 'Leukodystrophy, Metachromatic-screened-Gallbladder Diseases', 'Obesity-described-Myocardial Infarction', 'Lung Neoplasms-face-Death', 'Death-suffer-Chronic Disease', 'Colonic Neoplasms-extracted-Neoplasms', 'Colonic Neoplasms-diagnosed-Neoplasms', 'Hyper-IgM Immunodeficiency Syndrome, Type 1-result-Infections', 'Diabetes Mellitus-admitted-Fatigue', 'Diabetes Mellitus-admitted-Edema', 'Genetic Diseases, Inborn-characterized-Arrhythmogenic Right Ventricular Dysplasia', 'Obesity-show-Weight Loss', 'Death-cause-Spinal Cord Injuries', 'Death-caused-Obesity, Maternal', 'Hip Fractures-caused-Bone Neoplasms', 'Inflammation-predict-Peripheral Arterial Disease', 'Epilepsy-include-Spasms, Infantile', 'Arthritis, Rheumatoid-reduced-Cardiovascular Diseases', 'Arthritis, Rheumatoid-associated-Atherosclerosis', 'Atherosclerosis-associated-Arthritis, Rheumatoid', 'Hypertension-prevent-Glaucoma, Open-Angle', 'Stroke-classified-Infarction', 'Stroke-classified-Cerebral Hemorrhage', 'Cerebral Infarction-appear-Infarction', 'Death-used-Coronary Artery Disease', 'Neoplasms-differ-Myositis', 'Neoplasms-represent-Myositis', 'Urologic Neoplasms-lack-Neoplasms', 'Urologic Neoplasms-lack-Urinary Bladder Neoplasms', 'Neoplasms-lack-Urinary Bladder Neoplasms', 'Dyslipidemias-prevent-Cardiovascular Diseases', 'Dyslipidemias-treat-Cardiovascular Diseases', 'Biliary Dyskinesia-caused-Pancreatic Neoplasms', 'Pneumonia-suspect-Meningitis', 'Cerebral Infarction-compare-Ovarian Diseases', 'Stroke-compare-Ovarian Diseases', 'Metaplasia-keratinise-Neoplasms', 'Death-involve-Respiratory Tract Diseases', 'Hepatitis C-evaluate-Neoplasms', 'Neoplasm Metastasis-treated-Pain', 'Death-determine-Diabetes Mellitus', 'Cardiovascular Diseases-characterize-Joint Diseases', 'Osteoarthritis-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-Osteoarthritis', 'Joint Diseases-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-Joint Diseases', 'Cerebral Small Vessel Diseases-associate-Dementia', 'Dementia-associate-Cerebral Small Vessel Diseases', 'Cerebral Small Vessel Diseases-associate-Stroke', 'Stroke-associate-Cerebral Small Vessel Diseases', 'Hernia-present-Death', 'Heart Diseases-live-HIV Infections', 'Hypothalamic Neoplasms-collected-Colorectal Neoplasms', 'Brain Injuries-lead-Dehydration', 'Brain Injuries-lead-Pneumonia, Aspiration', 'Diabetes Mellitus, Type 2-explained-Fractures, Bone', 'Diabetes Mellitus-predispose-Fractures, Bone', 'Death-base-Breast Neoplasms', 'Death-base-Seizures', 'Death-survive-Cardiovascular Diseases', 'Arthritis, Rheumatoid-treat-Adrenal Insufficiency', 'Chronic Disease-treat-Adrenal Insufficiency', 'Inflammation-treat-Adrenal Insufficiency', 'Breast Neoplasms-irradiated-Neoplasm Metastasis', 'Neoplasms-involve-Prostatic Neoplasms', 'Death-exceed-Heart Diseases', 'Chronic Kidney Disease-Mineral and Bone Disorder-exceed-Heart Diseases', 'Prostatic Neoplasms-occur-Death', 'Colorectal Neoplasms-registered-Neoplasms', 'Death-use-Spinal Cord Injuries', 'Pancreatic Neoplasms-reflect-Adenocarcinoma', 'Colorectal Neoplasms-managed-Neoplasms', 'Uveitis-associated-Sarcoidosis', 'Sarcoidosis-associated-Uveitis', 'Prostatic Neoplasms-result-Death', 'Polycythemia Vera-estimate-Thrombosis', 'Thrombocythemia, Essential-estimate-Thrombosis', 'Death-expand-Tuberculosis', 'Cystic Fibrosis-punctuated-Pseudomonas Infections', 'Neoplasms-reduced-Amyotrophic Lateral Sclerosis', 'Amyotrophic Lateral Sclerosis-reduced-Lung Neoplasms', 'Neoplasms-documented-Drug-Related Side Effects and Adverse Reactions', 'Multiple Sclerosis-compare-Death', 'Venous Thromboembolism-increase-Venous Thrombosis', 'Venous Thromboembolism-improve-Venous Thrombosis', 'Spinal Cord Injuries-associated-Respiratory Tract Infections', 'Respiratory Tract Infections-associated-Spinal Cord Injuries', 'End Stage Liver Disease-caused-Abnormalities, Drug-Induced', 'Priapism-caused-Neoplasms', 'Opportunistic Infections-reduce-Acquired Immunodeficiency Syndrome', 'Digestive System Neoplasms-complicated-Thromboembolism', 'Neoplasms-complicated-Thromboembolism', 'Lung Neoplasms-delivered-Neoplasms', 'Hip Dislocation, Congenital-enrolled-Joint Dislocations', 'Hip Dislocation, Congenital-enrolled-Infections', 'Diabetes Mellitus-reduce-Coronary Artery Disease', 'Myotonic Dystrophy-increase-Hyperglycemia', 'Telangiectasia, Hereditary Hemorrhagic-provide-Death', 'Spondylarthropathies-associated-Kidney Failure, Chronic', 'Kidney Failure, Chronic-associated-Spondylarthropathies', 'Heart Failure-caused-Cardiomyopathies', 'Myopia-ascertain-Mastocytosis, Systemic', 'Glucose Intolerance-observed-Fibrosis', 'Diabetes Mellitus-observed-Fibrosis', 'Cystic Fibrosis-examined-Lung Diseases', 'Exocrine Pancreatic Insufficiency-examined-Lung Diseases', 'Alzheimer Disease-confirmed-Vision Disorders', 'Weight Loss-induce-Obesity', 'Arthritis, Rheumatoid-considered-Autoimmune Diseases', 'Death-cause-Lung Diseases', 'Death-cause-Dementia', 'Death-receive-Hemophilia A', 'Wounds and Injuries-defined-Hyperalgesia', 'Dementia-treated-Hypertension', 'Alzheimer Disease-treated-Hypertension', 'Hypertension-reflect-Alzheimer Disease', 'Familial Mediterranean Fever-associated-Coronary Artery Disease', 'Coronary Artery Disease-associated-Familial Mediterranean Fever', 'Familial Mediterranean Fever-associated-Death', 'Death-associated-Familial Mediterranean Fever', 'Neoplasm Metastasis-enrolled-Neoplasms', 'Gangliosidoses-created-Death', 'Diabetic Nephropathies-face-Death', 'Obesity-participate-Weight Loss', 'Obesity-pursue-Weight Loss', 'Neoplasms-diagnosed-Prostatic Neoplasms', 'Iatrogenic Disease-occur-Neoplasms', 'Metabolic Syndrome-attributed-Obesity', 'Metabolic Syndrome-attributed-Dyslipidemias', 'Hematoma, Subdural, Acute-appear-Death', 'Hematoma, Subdural, Acute-reported-Death', 'Learning Disabilities-living-Intellectual Disability', 'Intellectual Disability-living-Neoplasms', 'Intellectual Disability-living-Aneurysm', 'Ureteral Obstruction-related-Neoplasms', 'Coronary Artery Disease-represented-Diabetes Mellitus', 'Hyperlipidemias-show-Coronary Artery Disease', 'Cystic Fibrosis-become-Chronic Disease', 'Diabetes Mellitus-represented-Coronary Artery Disease', 'Hypertension-represented-Coronary Artery Disease', 'Chronic Disease-become-Infertility, Female', 'Neoplasms-set-Death', 'Breast Neoplasms-suffer-Metabolic Diseases', 'Colorectal Neoplasms-identify-Colorectal Neoplasms, Hereditary Nonpolyposis', 'Heart Diseases-associated-Death, Sudden, Cardiac', 'Death, Sudden, Cardiac-associated-Heart Diseases', 'Hypertension-improve-Albuminuria', 'Kidney Diseases-develop-Death', 'Diabetes Mellitus-observed-Hepatitis C', 'Albuminuria-identified-Diabetes Mellitus, Type 2', 'Kidney Diseases-identified-Diabetes Mellitus, Type 2', 'Neoplasm Metastasis-recognized-Ocular Hypertension', 'Liver Cirrhosis-relieve-Ascites', 'Pain-relieve-Neoplasm Metastasis', 'Pain-impending-Fractures, Bone', 'Neoplasm Metastasis-impending-Fractures, Bone', 'Carcinoma, Hepatocellular-increased-Fibrosis', 'Marfan Syndrome-associated-Aneurysm', 'Aneurysm-associated-Marfan Syndrome', 'Fibrosis-seen-Neoplasms', 'Fibrosis-detect-Neoplasms', 'Death-attributed-Neoplasm Metastasis', 'Neoplasms-attributed-Neoplasm Metastasis', 'Cystic Fibrosis-associated-Respiratory Tract Diseases', 'Respiratory Tract Diseases-associated-Cystic Fibrosis', 'Bone Diseases-associated-Respiratory Tract Diseases', 'Respiratory Tract Diseases-associated-Bone Diseases', 'HIV Infections-start-Immunologic Deficiency Syndromes', 'Amyotrophic Lateral Sclerosis-characterized-Motor Neuron Disease', 'Amyotrophic Lateral Sclerosis-characterized-Paralysis', 'Amyotrophic Lateral Sclerosis-characterized-Respiratory Insufficiency', 'Amyotrophic Lateral Sclerosis-characterized-Death', 'Motor Neuron Disease-lead-Paralysis', 'Diabetic Foot-contribute-Diabetes Mellitus', 'Motor Neuron Disease-lead-Respiratory Insufficiency', 'Motor Neuron Disease-lead-Death', 'Respiratory Insufficiency-lead-Paralysis', 'Death-lead-Paralysis', 'Neoplasms-include-Spinal Cord Neoplasms', 'Diabetes Mellitus-face-Diabetic Foot', 'Ovarian Neoplasms-undergo-Neoplasms', 'HIV Infections-associated-Hypertension, Pulmonary', 'Hypertension, Pulmonary-associated-HIV Infections', 'Renal Insufficiency-supposed-Anemia', 'Hypertension, Pulmonary-base-Stenosis, Pulmonary Artery', 'Hypertension, Pulmonary-base-HIV Infections', 'Hypertension, Pulmonary-live-HIV Infections', 'Stenosis, Pulmonary Artery-live-HIV Infections', 'Brain Injuries, Traumatic-present-Chronic Pain', 'Polycythemia Vera-include-Leukemia', 'Prostatic Neoplasms-diagnosed-Heart Failure', 'Polycythemia-include-Leukemia', 'Pain-span-Anemia, Sickle Cell', 'Colorectal Neoplasms, Hereditary Nonpolyposis-diagnosed-Colorectal Neoplasms', 'Multiple Myeloma-characterized-Death', 'Neoplasms-characterized-Death', 'Seizures-target-Leukemia, Myeloid, Acute', 'Colorectal Neoplasms-spare-Drug-Related Side Effects and Adverse Reactions', 'Optic Atrophy, Hereditary, Leber-associated-Death', 'Death-associated-Optic Atrophy, Hereditary, Leber', 'Optic Atrophy, Hereditary, Leber-associated-Stroke', 'Stroke-associated-Optic Atrophy, Hereditary, Leber', 'Optic Atrophy, Hereditary, Leber-associated-Demyelinating Diseases', 'Demyelinating Diseases-associated-Optic Atrophy, Hereditary, Leber', 'Optic Atrophy, Hereditary, Leber-associated-Dementia', 'Dementia-associated-Optic Atrophy, Hereditary, Leber', 'Optic Atrophy, Hereditary, Leber-associated-Epilepsy', 'Epilepsy-associated-Optic Atrophy, Hereditary, Leber', 'Epilepsy, Benign Neonatal-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-Epilepsy, Benign Neonatal', 'Anemia, Sickle Cell-result-Hemolysis', 'Death-show-Cardio-Renal Syndrome', 'Breast Neoplasms-needed-Death', 'Heart Defects, Congenital-matched-Death', 'Death-quantify-Lymphoma', 'Death-quantify-Hodgkin Disease', 'Hypoalphalipoproteinemias-find-Cardiovascular Diseases', 'Neoplasms-assessed-Pancreatitis', 'Neoplasms-assessed-Breast Neoplasms', 'Aortic Aneurysm, Abdominal-cause-Death', 'Venous Thrombosis-increase-Thrombosis', 'Fabry Disease-result-Immunologic Deficiency Syndromes', 'Thalassemia-reflect-Hypoparathyroidism', 'Biliary Tract Neoplasms-confirmed-Neoplasms', 'Death-lead-Agranulocytosis', 'Death-diagnosed-Sensation Disorders', 'Head and Neck Neoplasms-develop-Neoplasm Metastasis', 'Kidney Diseases-established-Renal Insufficiency, Chronic', 'Kidney Diseases-established-Cardiovascular Diseases', 'Iliac Aneurysm-feared-Sexual Dysfunction, Physiological', 'Kidney Diseases-established-Peripheral Nervous System Diseases', 'Hemochromatosis-develop-Diabetes Mellitus', 'Pneumonia, Pneumocystis-prevent-Drug-Related Side Effects and Adverse Reactions', 'Acquired Immunodeficiency Syndrome-expect-Pneumonia, Pneumocystis', 'Hemophilia A-take-Death', 'Hip Fractures-differ-Death', 'Sleep Apnea Syndromes-characterized-Hypoxia', 'Sleep Apnea Syndromes-associated-Diabetes Mellitus, Type 2', 'Diabetes Mellitus, Type 2-associated-Sleep Apnea Syndromes', 'Chronic Disease-associated-Scleroderma, Systemic', 'Scleroderma, Systemic-associated-Chronic Disease', 'Hypoxia-associated-Obesity', 'Obesity-associated-Hypoxia', 'Hypoxia-associated-Diabetes Mellitus, Type 2', 'Diabetes Mellitus, Type 2-associated-Hypoxia', 'Hypoxia-characterized-Cardiovascular Diseases', 'Sleep Wake Disorders-associated-Diabetes Mellitus, Type 2', 'Diabetes Mellitus, Type 2-associated-Sleep Wake Disorders', 'Death-collect-Cerebral Palsy', 'Shock-confront-Death', 'Colorectal Neoplasms-enrolled-Neoplasms', 'Aortic Aneurysm, Thoracic-associated-Ischemia', 'Ischemia-associated-Aortic Aneurysm, Thoracic', 'Hypertension, Pulmonary-compare-Pulmonary Arterial Hypertension', 'Condylomata Acuminata-associated-Neoplasms', 'Neoplasms-associated-Condylomata Acuminata', 'Hyperkalemia-improve-Heart Failure', 'Neoplasms-cause-HIV Infections', 'Urinary Bladder Neoplasms-reduce-Neoplasms', 'Death-related-Drug Overdose', 'End Stage Liver Disease-associated-Hepatitis C, Chronic', 'Hepatitis C, Chronic-associated-End Stage Liver Disease', 'Lung Neoplasms-related-Death', 'Brain Injuries, Traumatic-facilitate-Brain Injuries', 'Atrial Fibrillation-integrate-Stroke', 'Atrial Fibrillation-integrate-Hemorrhage', 'Lung Diseases-associated-Cystic Fibrosis', 'Cystic Fibrosis-associated-Lung Diseases', 'Neoplasms-fight-Leukemia, Lymphocytic, Chronic, B-Cell', 'Liver Failure-range-Fatty Liver', 'Liver Failure-range-Fibrosis', 'Fatty Liver-range-Cystic Fibrosis', 'Fibrosis-range-Cystic Fibrosis', 'Atrial Fibrillation-avoid-Stroke', 'Heart Failure-found-Mitral Valve Insufficiency', 'Atrial Fibrillation-avoid-Hemorrhage', 'Atrial Fibrillation-avoid-Myocardial Infarction', 'Atrial Fibrillation-avoid-Embolism', 'Communicable Diseases-measure-Infections', 'Atrial Fibrillation-avoid-Death', 'Unconsciousness-use-Brain Injuries, Traumatic', 'Psoriasis-regarded-Hypertension', 'Psoriasis-regarded-Myocardial Infarction', 'Psoriasis-regarded-Heart Valve Diseases', 'Psoriasis-regarded-Death, Sudden', 'Psoriasis-lead-Death, Sudden', 'Hypertension-lead-Death, Sudden', 'Myocardial Infarction-lead-Death, Sudden', 'Heart Valve Diseases-lead-Death, Sudden', 'Chordoma-investigated-Neoplasm Metastasis', 'Acquired Immunodeficiency Syndrome-delay-HIV Infections', 'Tuberculosis-classified-Tuberculosis, Pulmonary', 'Diabetes Mellitus-compare-Diabetes Mellitus, Type 2', 'Renal Insufficiency-help-Proteinuria', 'Anemia, Sickle Cell-help-Proteinuria', 'Proteinuria-detect-Kidney Diseases', 'Death-identify-Sarcoma, Kaposi', 'Death-identify-Lymphoma, Non-Hodgkin', 'Death-diagnosed-Lymphoma, Non-Hodgkin', 'Sarcoma, Kaposi-appear-Death', 'Lymphoma, Non-Hodgkin-appear-Death', 'Sarcoma, Kaposi-cause-Death', 'Lymphoma, Non-Hodgkin-cause-Death', 'Obesity-screen-Endometrial Neoplasms', 'Neoplasms-induce-von Hippel-Lindau Disease', 'Pain-base-Cerebral Palsy', 'Pain-seem-Cerebral Palsy', 'Cerebral Palsy-base-Joint Diseases', 'Pain-assess-Anemia, Sickle Cell', 'Drug-Related Side Effects and Adverse Reactions-treat-Colorectal Neoplasms', 'Infarction-outweigh-Heart Diseases', 'Diabetes Mellitus-eliminate-Eye Diseases', 'Neoplasms-stained-Pancreatic Neoplasms', 'Neoplasms-survive-Pulmonary Embolism', 'Thromboembolism-survive-Pulmonary Embolism', 'Carotid Stenosis-demonstrate-Death', 'Venous Thrombosis-survive-Pulmonary Embolism', 'Lung Neoplasms-detect-Neoplasm Metastasis', 'Death-related-Hemophilia A', 'Death-induced-Arbovirus Infections', 'Hemophilia A-induced-Arbovirus Infections', 'Immunologic Deficiency Syndromes-influence-Death', 'Immunologic Deficiency Syndromes-influence-Hemophilia A', 'Chemical and Drug Induced Liver Injury-influence-Death', 'Chemical and Drug Induced Liver Injury-influence-Hemophilia A', 'Death-study-Aortic Coarctation', 'Melanoma-obtained-Neoplasms', 'Psychoses, Substance-Induced-present-Stroke', 'Psychoses, Substance-Induced-associated-Death', 'Death-associated-Psychoses, Substance-Induced', 'Muscular Dystrophy, Duchenne-include-Fractures, Bone', 'Muscular Dystrophy, Duchenne-include-Hip Fractures', 'Fractures, Bone-fall-Compassion Fatigue', 'Neoplasms-affected-Multiple Sclerosis', 'Lupus Nephritis-progress-Renal Insufficiency', 'Neuroma, Acoustic-identified-Brain Neoplasms', 'Kidney Diseases-induce-Fragile X Syndrome', 'Kidney Diseases-induce-Kidney Failure, Chronic', 'Metabolic Diseases-induce-Fragile X Syndrome', 'Metabolic Diseases-induce-Kidney Failure, Chronic', 'HIV Infections-remain-Death', 'Glucosephosphate Dehydrogenase Deficiency-result-Genetic Diseases, X-Linked', 'Neoplasms-provide-Pancreatic Neoplasms', 'Atherosclerosis-prevent-Coronary Artery Disease', 'Heart Failure-prevent-Myocardial Infarction', 'Heart Failure-prevent-Coronary Artery Disease', 'Melanoma-correlated-Neoplasms', 'Death-improve-Cardiovascular Diseases', 'Ischemia-decrease-Multiple Organ Failure', 'Shock, Septic-decrease-Multiple Organ Failure', 'Death-address-Hypertension', 'Long QT Syndrome-undergo-Colorectal Neoplasms', 'Long QT Syndrome-identified-Colorectal Neoplasms', 'Death-quadrup-Liver Diseases', 'Death-quadrup-Fibrosis', 'Pain-encountered-Cystic Fibrosis', 'Hemophilia A-avoid-Hemorrhage', 'Wiskott-Aldrich Syndrome-characterized-Eczema', 'Wiskott-Aldrich Syndrome-characterized-Infections', 'Wiskott-Aldrich Syndrome-characterized-Autoimmune Diseases', 'Wiskott-Aldrich Syndrome-characterized-Neoplasms', 'X-Linked Combined Immunodeficiency Diseases-characterized-Eczema', 'X-Linked Combined Immunodeficiency Diseases-characterized-Infections', 'X-Linked Combined Immunodeficiency Diseases-characterized-Autoimmune Diseases', 'X-Linked Combined Immunodeficiency Diseases-characterized-Neoplasms', 'Telangiectasia, Hereditary Hemorrhagic-present-Anemia, Iron-Deficiency', 'Telangiectasia, Hereditary Hemorrhagic-present-Abnormalities, Drug-Induced', 'Genetic Diseases, Inborn-present-Anemia, Iron-Deficiency', 'Genetic Diseases, Inborn-present-Abnormalities, Drug-Induced', 'Neoplasms-considered-Prostatic Neoplasms', 'Chronic Disease-cause-Joint Diseases', 'Ehlers-Danlos Syndrome-cause-Rupture', 'Death-thrive-Pneumonia', 'Death-thrive-Dehydration', 'Death-thrive-Anemia', 'Death-thrive-Sepsis', 'Respiratory Insufficiency-thrive-Pneumonia', 'Respiratory Insufficiency-thrive-Dehydration', 'Respiratory Insufficiency-thrive-Anemia', 'Respiratory Insufficiency-thrive-Sepsis', 'Pneumonia-thrive-Dehydration', 'Pneumonia-thrive-Anemia', 'Pneumonia-thrive-Sepsis', 'Pain-compiled-Neoplasm Metastasis', 'Urinary Bladder Neoplasms-occur-Death', 'Dehydration-thrive-Anemia', 'Dehydration-thrive-Sepsis', 'Carcinoma, Non-Small-Cell Lung-undergo-Death', 'Anemia-thrive-Sepsis', 'Carcinoma, Non-Small-Cell Lung-undergo-Lung Neoplasms', 'Crohn Disease-experience-Respiratory Distress Syndrome', 'Crohn Disease-associated-Chronic Disease', 'Chronic Disease-associated-Crohn Disease', 'Anorexia-related-Neoplasms', 'Myocardial Infarction-demonstrate-Stroke', 'Myocardial Infarction-demonstrate-Hemorrhage', 'Dystonia-progress-Death', 'Arterial Occlusive Diseases-found-Renal Artery Obstruction', 'Subarachnoid Hemorrhage-survive-Aneurysm, Ruptured', 'Subarachnoid Hemorrhage-survive-Aneurysm', 'Spinal Stenosis-reduce-Death', 'Neoplasms-identify-Neoplasm Metastasis', 'Neurofibrosarcoma-arose-Neurofibroma', 'Melanoma-compare-Neoplasms', 'Short Bowel Syndrome-result-Malabsorption Syndromes', 'Stroke-compare-Venous Thrombosis', 'Cerebral Infarction-compare-Venous Thrombosis', 'Adenomatous Polyposis Coli-lie-Death', 'Adenomatous Polyposis Coli-lie-Neoplasms', 'Death-revert-Melanoma', 'Corneal Diseases-manifest-Nystagmus, Pathologic', 'Testicular Neoplasms-harbor-Neoplasms', 'Teratoma-harbor-Neoplasms', 'Arthritis, Rheumatoid-influence-Death', 'Death-related-Arthritis, Rheumatoid', 'Arthritis, Rheumatoid-represent-Death', 'Hypertension-compare-Death', 'Cerebral Infarction-involve-Arterial Occlusive Diseases', 'Cerebral Infarction-result-Arterial Occlusive Diseases', 'Cerebral Infarction-involve-Ischemia', 'Cerebral Infarction-result-Ischemia', 'Sarcopenia-identified-Death', 'Primary Ovarian Insufficiency-include-Ovarian Diseases', 'Cardiovascular Diseases-mediated-Metabolic Diseases', 'Neoplasms-subclassify-Seminoma', 'Myotonic Dystrophy-associated-Myotonia', 'Myotonia-associated-Myotonic Dystrophy', 'Genetic Diseases, Inborn-associated-Myotonia', 'Myotonia-associated-Genetic Diseases, Inborn', 'Oculocerebrorenal Syndrome-associated-Death', 'Death-associated-Oculocerebrorenal Syndrome', 'Lymphoma, B-Cell, Marginal Zone-manage-Lymphoma, T-Cell, Cutaneous', 'Renal Insufficiency, Chronic-associated-Cardiac Complexes, Premature', 'Cardiac Complexes, Premature-associated-Renal Insufficiency, Chronic', 'Esophagitis-lead-Deglutition Disorders', 'Esophagitis-lead-Malnutrition', 'Carcinoma, Non-Small-Cell Lung-develop-Exanthema', 'Fatigue-affect-Cerebral Infarction', 'Adenocarcinoma-confirm-Neoplasms', 'Pulmonary Disease, Chronic Obstructive-describe-Death', 'Sarcoma-expand-Neoplasms', 'Breast Neoplasms-associated-Infertility, Female', 'Infertility, Female-associated-Breast Neoplasms', 'Peripheral Arterial Disease-predict-Renal Artery Obstruction', 'Renal Artery Obstruction-predict-Death', 'Renal Artery Obstruction-undergo-Peripheral Arterial Disease', 'Anemia, Sickle Cell-suffer-Pain', 'Infections-show-Death', 'Dementia-reflect-Pneumonia', 'Dementia-reflect-Death', 'Neoplasms-employed-Carcinoma', 'Carcinoma-undergo-Neoplasm Metastasis', 'Pain-prevent-Nervous System Diseases', 'Nervous System Diseases-reduce-Neoplasms', 'Colorectal Neoplasms-caused-Neoplasms', 'Chronic Disease-shorten-Obesity', 'Colonic Pseudo-Obstruction-caused-Neoplasms', 'Aortic Aneurysm, Abdominal-related-Death', 'Death-diagnosed-Crohn Disease', 'von Hippel-Lindau Disease-caused-Neoplasms', 'Stroke-estimate-Atrial Fibrillation', 'Leukemia-altered-Neoplasms', 'Menkes Kinky Hair Syndrome-exhibit-Myopia', 'Death-assessed-HIV Infections', 'Communicable Diseases-remain-Ischemia', 'HIV Infections-do-Neoplasms', 'Alzheimer Disease-predispose-Dementia, Vascular', 'Sensation Disorders-support-Muscle Spasticity', 'Obesity-associated-Epilepsy, Temporal Lobe', 'Epilepsy, Temporal Lobe-associated-Obesity', 'Neoplasms-diagnosed-Neoplasm Metastasis', 'Pain, Postoperative-undergo-Musculoskeletal Diseases', 'Ocular Hypertension-Uveal-Melanoma', 'Primary Myelofibrosis-characterized-Hematologic Diseases', 'Primary Myelofibrosis-characterized-Cell Transformation, Viral', 'Stroke-use-Death', 'Myeloproliferative Disorders-characterized-Hematologic Diseases', 'Myeloproliferative Disorders-characterized-Splenomegaly', 'Myeloproliferative Disorders-characterized-Cell Transformation, Viral', 'Death-differ-Dementia', 'Death-avoid-Chronic Pain', 'Hematoma-include-Aortic Aneurysm, Thoracic', 'Renal Insufficiency, Chronic-fall-Cardiac Output, Low', 'Renal Insufficiency, Chronic-suffer-Wounds and Injuries', 'Pancreatic Neoplasms-undergo-Gastric Outlet Obstruction', 'Cardiac Output, Low-suffer-Wounds and Injuries', 'Carcinoma, Pancreatic Ductal-discuss-Metabolic Diseases', 'Carcinoma, Pancreatic Ductal-precede-Neoplasms', 'Metabolic Diseases-precede-Neoplasms', 'Stroke-transition-Hemorrhage', 'Death-transition-Hemorrhage', 'Cerebral Infarction-establish-Peripheral Arterial Disease', 'Death-occur-Medulloblastoma', 'Aortic Diseases-include-Aneurysm', 'Aortic Aneurysm-included-Aneurysm', 'Aortic Aneurysm-included-Aneurysm, Ruptured', 'Cystic Fibrosis-become-Diabetes Mellitus', 'Multiple Myeloma-require-Death', 'Eye Diseases-occur-Mastocytosis, Systemic', 'Amyotrophic Lateral Sclerosis-characterized-Brain Diseases', 'Multiple Myeloma-experience-Renal Insufficiency', 'Hemochromatosis-considered-Hemorrhage', 'Neurodegenerative Diseases-characterized-Brain Diseases', 'Multiple Myeloma-improve-Huntington Disease', 'Huntington Disease-assess-Multiple Myeloma', 'Huntington Disease-compare-Multiple Myeloma', 'Cystic Fibrosis-varied-Mastocytosis, Systemic', 'Brain Injuries, Traumatic-confer-Death', 'Cystic Fibrosis-varied-Malnutrition', 'Death-compare-Foot Ulcer', 'Death-present-Ulcer', 'Shock, Septic-enrol-Sepsis', 'Shock, Septic-appear-Sepsis', 'Spinal Cord Injuries-evaluate-Prostatic Hyperplasia', 'Carcinoma, Non-Small-Cell Lung-designed-Death', 'Death-correspond-Chemical and Drug Induced Liver Injury', 'Death-correspond-Hepatitis, Autoimmune', 'Chemical and Drug Induced Liver Injury-correspond-Hepatitis, Autoimmune', 'Chemical and Drug Induced Liver Injury-caused-Death', 'Death-operate-Heart Failure', 'Colorectal Neoplasms, Hereditary Nonpolyposis-including-Neoplasms', 'Retinal Detachment-associated-Cytomegalovirus Retinitis', 'Cytomegalovirus Retinitis-associated-Retinal Detachment', 'Retinal Detachment-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-Retinal Detachment', 'Retinal Detachment-associated-Vitreoretinopathy, Proliferative', 'Vitreoretinopathy, Proliferative-associated-Retinal Detachment', 'Retinal Detachment-associated-Wounds and Injuries', 'Wounds and Injuries-associated-Retinal Detachment', 'Cytomegalovirus Retinitis-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-Cytomegalovirus Retinitis', 'Cytomegalovirus Retinitis-associated-Vitreoretinopathy, Proliferative', 'Vitreoretinopathy, Proliferative-associated-Cytomegalovirus Retinitis', 'Cytomegalovirus Retinitis-associated-Wounds and Injuries', 'Wounds and Injuries-associated-Cytomegalovirus Retinitis', 'Opportunistic Infections-prevent-HIV Infections', 'Cardiomyopathies-identified-Amyloidosis', 'Cardiomyopathies-matched-Amyloidosis', 'Death-modelled-Neoplasms', 'Kidney Neoplasms-develop-Neoplasms', 'Malocclusion-use-Death', 'Death-assess-Hemophilia A', 'Death-observed-Chronic Disease', 'Acquired Immunodeficiency Syndrome-experience-Neoplasms', 'Pericardial Effusion-associated-Neoplasms', 'Neoplasms-associated-Pericardial Effusion', 'Thyroid Neoplasms-increase-Death', 'Acquired Immunodeficiency Syndrome-used-Death', 'Acquired Immunodeficiency Syndrome-related-Death', 'Chronic Disease-reduce-Communicable Diseases', 'Death-compare-Pain Insensitivity, Congenital', 'Diabetes Mellitus, Type 2-confer-Diabetes Mellitus', 'Osteoporotic Fractures-confer-Death', 'Osteoporotic Fractures-confer-Diabetes Mellitus', 'Diabetes Mellitus, Type 2-sustain-Fractures, Bone', 'Leukemia, Myelogenous, Chronic, BCR-ABL Positive-included-Death', 'Leukemia, Myelogenous, Chronic, BCR-ABL Positive-follow-Death', 'Neoplasms-included-Death', 'Osteoarthritis-use-Pain', 'Osteoarthritis-control-Pain', 'Eclampsia-progress-Death', 'Pulmonary Arterial Hypertension-lead-Cardiomyopathy, Hypertrophic', 'Kidney Failure, Chronic-enrolled-Diabetes Mellitus', 'Kidney Failure, Chronic-diagnosed-Diabetes Mellitus', 'Hepatomegaly-find-Polycystic Kidney Diseases', 'Huntington Disease-require-Kidney Failure, Chronic', 'Kidney Diseases-use-Arteriovenous Fistula', 'Acquired Immunodeficiency Syndrome-monitor-Death', 'Sclerosis-associated-Cardiac Complexes, Premature', 'Cardiac Complexes, Premature-associated-Sclerosis', 'Aneurysm-associated-Cardiac Complexes, Premature', 'Cardiac Complexes, Premature-associated-Aneurysm', 'Hepatitis B-include-Arbovirus Infections', 'Cataract-related-Macular Degeneration', 'Glaucoma-related-Macular Degeneration', 'Lung Neoplasms-living-HIV Infections', 'Amyotrophic Lateral Sclerosis-characterized-Nerve Degeneration', 'Urinary Bladder Neoplasms-use-Disease Progression', 'Airway Obstruction-related-Neoplasms', 'Chronic Disease-select-Hypertension', 'Chronic Disease-select-Angina, Stable', 'Chronic Disease-select-Atrial Fibrillation', 'Chronic Disease-select-Hypercholesterolemia', 'Chronic Disease-select-Diabetes Mellitus', 'Chronic Disease-select-Osteoarthritis', 'Chronic Disease-select-Osteoporosis', 'Stomach Neoplasms-prevent-Esophageal Neoplasms', 'Pain-suffer-Pancreatic Neoplasms', 'Death-validated-Immunologic Deficiency Syndromes', 'Death-validated-Neoplasms', 'Angina Pectoris-used-Coronary Artery Disease', 'Death-confined-Ulcer', 'Myocardial Infarction-compare-Coronary Artery Disease', 'Peritoneal Neoplasms-found-Carcinoid Tumor', 'Peritoneal Neoplasms-found-Pancreatic Neoplasms', 'Peritoneal Neoplasms-found-Gastrinoma', 'Acquired Immunodeficiency Syndrome-live-HIV Infections', 'Acquired Immunodeficiency Syndrome-use-Sarcoma, Kaposi', 'Acquired Immunodeficiency Syndrome-project-Sarcoma, Kaposi', 'Cerebral Palsy-increase-Liver Diseases', 'Neoplasm Metastasis-derived-Carcinoma, Hepatocellular', 'Carcinoma, Hepatocellular-identified-Neoplasm Metastasis', 'Spinal Diseases-identified-Neoplasm Metastasis', 'Prostatic Neoplasms-rank-Death', 'Heart Failure-increase-Death, Sudden, Cardiac', 'Dementia-increase-Death, Sudden, Cardiac', 'Pain-diagnosed-Carcinoma, Squamous Cell', 'Muscular Dystrophy, Duchenne-lose-Upper Extremity Deformities, Congenital', 'Upper Extremity Deformities, Congenital-lose-Death', 'Hearing Loss, Central-present-Hearing Loss', 'Osteoarthritis-used-Death', 'Osteoarthritis-lost-Death', 'Crigler-Najjar Syndrome-admitted-Cholangitis', 'Gallstones-increased-Crigler-Najjar Syndrome', 'Atrial Fibrillation-based-Stroke', 'Prostatic Neoplasms-extracted-Neoplasms', 'Atrial Fibrillation-based-Hemorrhage', 'Hodgkin Disease-face-Lung Neoplasms', 'Stroke-result-Atrial Fibrillation', 'Stroke-integrate-Atrial Fibrillation', 'Hemorrhage-result-Atrial Fibrillation', 'Hemorrhage-integrate-Atrial Fibrillation', 'Wounds and Injuries-account-Ischemia', 'Hip Fractures-increase-Osteoporosis', 'X-Linked Combined Immunodeficiency Diseases-transplanted-Leukemia, Myeloid', 'Hypercalcemia-related-Neoplasms', 'DR1-observed-Lipopolysaccharides', 'PCA3-considered-NPEPPS', 'Glucose-combine-INS', 'Lipodystrophy-include-INS', 'Lipodystrophy-include-Glucose', 'INS-increase-Hypothalamic Diseases', 'Glucose-increase-Hypothalamic Diseases', 'SIRT6-reduced-Atherosclerosis', 'Fatty Acids-improve-INS', 'Hypoglycemia-reduce-Insulin Glargine', 'PCSK9-approved-Cholesterol', 'PCSK9-approved-Atherosclerosis', 'PTH-observed-Acute Kidney Injury', 'Acute Kidney Injury-observed-Calcitriol', 'Diabetes Mellitus-used-Exenatide', 'Diabetes Mellitus-receive-Exenatide', 'MME-associated-Enalapril', 'Enalapril-associated-MME', 'MME-associated-Death', 'Death-associated-MME', 'Diabetes Mellitus-used-INS', 'Diabetes Mellitus-used-Insulin Glargine', 'Diabetes Mellitus-transfer-INS', 'Exenatide-evaluate-Diabetes Mellitus', 'Exenatide-improve-Diabetes Mellitus', 'Octreotide-compared-GH1', 'Trastuzumab-revolutionize-Breast Neoplasms', 'ZPR1-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-ZPR1', 'rs964184-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-rs964184', 'rs4645878-associated-BAX', 'BAX-associated-rs4645878', 'Dementia-caused-CHMP2B', 'Dementia-caused-rs63750652', 'FTO-occur-Weight Gain', 'rs9939609-occur-Weight Gain', 'Stomach Neoplasms-associated-CDH1', 'CDH1-associated-Stomach Neoplasms', 'MMP7-associated-Renal Insufficiency, Chronic', 'Renal Insufficiency, Chronic-associated-MMP7', 'Neoplasms-regulated-TLR4', 'Acquired Immunodeficiency Syndrome-use-CD4', 'Acquired Immunodeficiency Syndrome-vary-CD4', 'Stomach Neoplasms-treat-TLR4', 'Stomach Neoplasms-regulate-TLR4', 'AMH-used-Neoplasms', 'AMH-identify-Neoplasms', 'EDNRB-stimulate-Brain Ischemia', 'Prostatic Neoplasms-receive-KLK3', 'Rare Diseases-caused-LDLR', 'Neoplasms-associated-ERCC1', 'ERCC1-associated-Neoplasms', 'SCGB1A1-approved-Pulmonary Disease, Chronic Obstructive', 'ERCC1-use-Esophageal Neoplasms', 'Breast Neoplasms-diagnosed-ERBB2', 'FSHR-associated-Alzheimer Disease', 'Alzheimer Disease-associated-FSHR', 'APOE-act-Alzheimer Disease', 'Alzheimer Disease-estimate-APOE', 'Muscular Diseases-associated-MYH7', 'MYH7-associated-Muscular Diseases', 'MYH7-cause-Muscular Diseases', 'SIRT1-become-Neurodegenerative Diseases', 'SIRT1-prevent-Cardiovascular Diseases', 'Genetic Diseases, Inborn-caused-FAM20C', 'PTH-associated-Weight Loss', 'Weight Loss-associated-PTH', 'Neoplasms-associated-NF1', 'NF1-associated-Neoplasms', 'Neurilemmoma-predispose-NF2', 'TNF-compared-Inflammatory Bowel Diseases', 'KLK3-screen-Prostatic Neoplasms', 'Heart Failure-increase-CD4', 'IL2-evaluate-Death', 'BRAF-investigated-Melanoma', 'EGFR-progress-Carcinoma, Non-Small-Cell Lung', 'Diabetes Mellitus-base-INS', 'Prostatic Neoplasms-recognized-KLK3', 'SOD1-modify-Liver Neoplasms', 'INS-diagnosed-Diabetes Mellitus', 'CD4-constitute-Acquired Immunodeficiency Syndrome', 'MAOB-modulate-Parkinson Disease', 'Neoplasms-divided-CRP', 'NPEPPS-increase-Prostatic Neoplasms', 'CRP-investigated-Neoplasms', 'CEACAM3-characterize-Neoplasms', 'INS-estimated-Diabetes Mellitus, Type 2', 'CEACAM3-treated-Colorectal Neoplasms', 'CEACAM3-expired-Colorectal Neoplasms', 'Neurofibroma-reveal-VEGFA', 'IAPP-improve-Glucose Metabolism Disorders', 'SPP1-correlate-Neoplasms', 'AMH-assess-Polycystic Ovary Syndrome', 'Polycystic Ovary Syndrome-measured-AMH', 'Diabetes Mellitus-examine-INS', 'ELN-contribute-Pain', 'GPT-correlated-Death', 'Cerebral Infarction-increase-SST', 'Parkinson Disease-provide-RPL3', 'FOLH1-overexpressed-Prostatic Neoplasms', 'BTK-revolutionize-Leukemia, Lymphocytic, Chronic, B-Cell', 'CRTC1-contribute-Obesity', 'BRAF-produce-Melanoma', 'Leukemia, Lymphocytic, Chronic, B-Cell-treated-BTK', 'EGFR-loaded-Growth Disorders', 'Neoplasms-associated-VEGFA', 'VEGFA-associated-Neoplasms', 'TNFSF11-observed-Periodontitis', 'MSTN-treat-Urinary Incontinence, Stress', 'Stomach Neoplasms-prevent-CDH1', 'PLAU-involved-Neoplasms', 'Prostatic Neoplasms-diagnosed-KLK3', 'Breast Neoplasms-contribute-AMH', 'APOB-emerging-Coronary Artery Disease', 'CRP-prevent-Coronary Artery Disease', 'TF-detect-Hemochromatosis', 'Cystic Fibrosis-expected-CFTR', 'Hemochromatosis-detected-GPT', 'Cystic Fibrosis-enhance-CFTR', 'Renal Insufficiency-remain-EPO', 'BYSL-upregulated-Inflammation', 'BYSL-elevated-Glioma', 'BYSL-promote-Glioma', 'Achondroplasia-caused-FGFR3', 'Lung Neoplasms-harbor-EGFR', 'MUC16-associated-Death', 'Death-associated-MUC16', 'CBX7-downregulate-Neoplasms', 'CBX7-overexpressed-Stomach Neoplasms', 'DAPK3-represented-Epididymitis', 'Liver Neoplasms-include-TARDBP', 'KLK3-form-Neoplasms', 'KLK3-enhance-Neoplasms', 'ATAD3A-lead-Cardiomyopathies', 'CFTR-explain-Infertility, Female', 'URI1-examined-Heart Failure', 'HSPA8-involved-Papilledema', 'Heart Arrest-reinforce-CDKN2A', 'CPT1A-play-Mitochondrial Diseases', 'KL-confer-Neurodegenerative Diseases', 'INS-ensue-Diabetes Mellitus', 'Death-identified-NF2', 'TF-improve-Diabetes Mellitus', 'Prostatic Neoplasms-define-KLK3', 'TTR-cause-Amyloidosis', 'SLC5A2-recommend-Diabetes Mellitus', 'SLC5A2-improve-Diabetes Mellitus', 'FGF19-reduced-Obesity', 'ARF6-use-Breast Neoplasms', 'ARF6-promote-Neoplasms', 'DDN-observed-Kidney Diseases', 'Diabetes Mellitus-become-INS', 'CFTR-cause-Infertility, Female', 'SIRT5-promote-Thrombosis', 'Cystic Fibrosis-evaluated-CFTR', 'Hereditary Autoinflammatory Diseases-caused-UBA1', 'KL-associate-Inflammation', 'Inflammation-associate-KL', 'AFP-used-Carcinoma, Hepatocellular', 'Diabetes Mellitus-experience-INS', 'Medulloblastoma-found-PLK5', 'SMN1-characterized-Respiratory Insufficiency', 'Neoplasm Metastasis-treated-KLK3', 'Acromegaly-lead-VEGFA', 'VEGFA-implicated-Cardiovascular Diseases', 'ERBB2-follow-Breast Neoplasms', 'SDHD-reduced-Carotid Body Tumor', 'Cystic Fibrosis-correlated-MUC1', 'FAM20C-cause-Genetic Diseases, Inborn', 'BDNF-confer-Alzheimer Disease', 'BDNF-predict-Alzheimer Disease', 'KAT2B-acetylated-Esophageal Squamous Cell Carcinoma', 'Diabetes Mellitus-purchase-INS', 'PDE4B-treat-Heart Failure', 'Seizures-change-CLN3', 'DKK3-decline-Renal Insufficiency, Chronic', 'SIRT1-play-Inflammation', 'FNDC5-remain-Cerebral Small Vessel Diseases', 'INS-shown-Hyperglycemia', 'G6PD-detected-Jaundice', 'Neurofibrosarcoma-reveal-NF1', 'Jaundice-screened-G6PD', 'Diabetes Mellitus-predict-HFE', 'BRCA1-provide-Death', 'Hepatitis C, Chronic-return-GPT', 'TERF2-imply-Neoplasm Metastasis', 'Drug-Related Side Effects and Adverse Reactions-assess-VEGFA', 'IFNA1-increase-Drug-Related Side Effects and Adverse Reactions', 'Breast Neoplasms-associated-EREG', 'EREG-associated-Breast Neoplasms', 'Laryngeal Neoplasms-evaluated-CSE1L', 'CSE1L-demonstrate-Neoplasms', 'HIV Infections-display-AKT1', 'APOE-influence-Dementia', 'ABL1-improve-Leukemia, Myelogenous, Chronic, BCR-ABL Positive', 'MTMR2-expressed-Stomach Neoplasms', 'MTMR2-examined-Stomach Neoplasms', 'MTMR2-found-Neoplasms', 'Melanoma-encode-CDKN2A', 'HMBS-reported-Brain Diseases', 'PCA3-detect-Prostatic Neoplasms', 'PCA3-avoid-Prostatic Neoplasms', 'Doxorubicin-composed-Cholesterol', 'Lymphoma-include-Doxorubicin', 'Exenatide-shown-Glucose', 'Lymphoma-include-Rituximab', 'Kidney Failure, Chronic-treated-Glucose', 'Kidney Failure, Chronic-use-Glucose', 'Neoplasms-retain-Anthracyclines', 'Etoposide-improve-Lung Neoplasms', 'Sugars-associated-Death', 'Death-associated-Sugars', 'Hemorrhage-receive-Heparin', 'Vancomycin-target-Infections', 'Chronic Disease-show-Glucose', 'Glucose-use-Diabetes Mellitus, Type 2', 'Glucose-offered-Diabetes, Gestational', 'Doxorubicin-associated-Drug-Related Side Effects and Adverse Reactions', 'Drug-Related Side Effects and Adverse Reactions-associated-Doxorubicin', 'Doxorubicin-loaded-Cholangiocarcinoma', 'Glucose-associated-Atrial Fibrillation', 'Atrial Fibrillation-associated-Glucose', 'Fluorodeoxyglucose F18-remain-Neoplasms', 'Heparin-develop-Respiratory Insufficiency', 'Diabetes Mellitus-normalise-Glucose', 'Glucose-obtained-Diabetes Mellitus', 'Glucose-intensify-Diabetes Mellitus', 'Glycosaminoglycans-result-Metabolic Diseases', 'Sepsis-prevent-Heparin', 'Hypothalamic Diseases-decrease-Glucose', 'Antithrombin III Deficiency-induce-Heparin', 'Bleomycin-prevent-Pleural Effusion, Malignant', 'Diabetes, Gestational-use-Glucose', 'Diabetes Mellitus-used-Acarbose', 'Diabetes Mellitus-receive-Acarbose', 'Diabetes Mellitus-correlate-Glucose', 'Lipopolysaccharides-aggravate-Inflammation', 'Doxorubicin-sever-Drug-Related Side Effects and Adverse Reactions', 'Doxorubicin-shown-Breast Neoplasms', 'Cystic Fibrosis-recommended-Glucose', 'Leukemia, Lymphoid-give-Nucleosides', 'Breast Neoplasms-treat-Anthracyclines', 'Nadroparin-administer-Neoplasms', 'Fructosamine-associated-Retinal Diseases', 'Retinal Diseases-associated-Fructosamine', 'Fructosamine-predict-Retinal Diseases', 'Glucose-aid-Diabetes Mellitus', 'Diabetes Mellitus-follow-Glucose', 'Thrombosis-treated-Heparin', 'Carcinoma, Hepatocellular-induced-Polysaccharides', 'Glucose-reverse-Neoplasms', 'Acute Kidney Injury-perform-Lipopolysaccharides', 'Death-mediated-Glucose', 'Chemical and Drug Induced Liver Injury-used-Doxorubicin', 'Heparin-undergo-Myocardial Infarction', 'Neoplasms-assigned-Nadroparin', 'Neoplasms-receive-Nadroparin', 'Hyperlactatemia-undergo-Heparin, Low-Molecular-Weight', 'Heparin, Low-Molecular-Weight-influence-Neoplasms', 'Glucose-help-Diabetes Mellitus', 'Enoxaparin-dominate-Venous Thromboembolism', 'Anthracyclines-undermined-Cardiotoxicity', 'Heparin, Low-Molecular-Weight-treat-Venous Thrombosis', 'HIV Infections-demonstrate-Glucose', 'Coronary Artery Disease-base-Cholesterol', 'Graft vs Host Disease-compare-Mycophenolic Acid', 'Graft vs Host Disease-compare-Cyclosporine', 'Sensation Disorders-lowering-Glucose', 'Caspofungin-expected-Mycoses', 'Cholesterol-incorporate-Death', 'Fatty Acids-integrate-Metabolic Syndrome', 'Thioctic Acid-reduce-Neoplasms', 'Cholesterol-change-Diabetes Mellitus', 'Fish Oils-associated-Prostatic Neoplasms', 'Prostatic Neoplasms-associated-Fish Oils', 'Dementia-protect-Calcifediol', 'Cardiovascular Diseases-appear-Atorvastatin', 'Cholecalciferol-improve-Death', 'Coronary Artery Disease-receive-Cholesterol', 'Micafungin-increase-Infections', 'Cholesterol-associated-Pancreatitis, Graft', 'Pancreatitis, Graft-associated-Cholesterol', 'Caspofungin-compare-Fever', 'Thioctic Acid-represent-Infertility, Female', 'Metabolic Syndrome-influence-Cholesterol', 'Fatty Acids-implicated-Inflammation', 'Arachidonic Acid-surround-Inflammation', 'Leukotrienes-induce-Aneurysm', 'Stroke-expected-Atorvastatin', 'Neuroendocrine Tumors-considered-Octreotide', 'Atorvastatin-prescribe-Stroke', 'Diabetes Mellitus-compare-Insulin Glargine', 'Diabetes Mellitus-controlled-Insulin Glargine', 'Diabetes Mellitus, Type 2-increased-Exenatide', 'Teriparatide-represent-Bone Diseases', 'Insulin Glargine-cost-Diabetes Mellitus', 'Insulin Glargine-save-Diabetes Mellitus', 'Atazanavir Sulfate-associated-Hyperbilirubinemia', 'Hyperbilirubinemia-associated-Atazanavir Sulfate', 'Acquired Immunodeficiency Syndrome-use-Atazanavir Sulfate', 'Acquired Immunodeficiency Syndrome-project-Atazanavir Sulfate', 'Octreotide-demonstrate-Acromegaly', 'Trimethoprim, Sulfamethoxazole Drug Combination-reduce-Granulomatosis with Polyangiitis', 'Rituximab-extend-Lymphoma', 'Trastuzumab-recommend-Neoplasms', 'Trastuzumab-label-Cardiotoxicity', 'Melanoma-estimate-Ipilimumab', 'Infliximab-demonstrate-Crohn Disease', 'Nivolumab-extend-Carcinoma, Non-Small-Cell Lung', 'Alemtuzumab-suggest-Hypereosinophilic Syndrome', 'Arthritis, Rheumatoid-associated-Rituximab', 'Rituximab-associated-Arthritis, Rheumatoid', 'Breast Neoplasms-emphasize-Trastuzumab', 'Rituximab-improve-Lymphoma, Non-Hodgkin', 'Nivolumab-associated-Carcinoma, Squamous Cell', 'Carcinoma, Squamous Cell-associated-Nivolumab', 'Rituximab-remain-Lymphoma', 'Breast Neoplasms-assigned-Trastuzumab', 'Breast Neoplasms-receive-Trastuzumab', 'Melanoma-correspond-Ipilimumab', 'Crohn Disease-indicate-Adalimumab', 'Stomach Neoplasms-obtained-Trastuzumab', 'Trastuzumab-provide-Neoplasms', 'Trastuzumab-obtained-Stomach Neoplasms', 'Breast Neoplasms-given-Trastuzumab', 'Cardiomyopathy, Hypertrophic-caused-rs121908033', 'Heart Failure-enrolled-rs1799964', 'rs6265-predict-Alzheimer Disease', 'Xeroderma Pigmentosum-present-rs746319045', 'MIR34A-modulate-CASP3', 'Fibrosis-observe-Oculocerebrorenal Syndrome', 'SNAI2-contribute-Fibrosis', 'SNAI2-observe-Oculocerebrorenal Syndrome', 'OCRL-contribute-Fibrosis', 'OCRL-observe-Oculocerebrorenal Syndrome', 'Leukemia, Myeloid, Acute-drive-Leukemia', 'Leukemia-drive-ETV6', 'CFTR-play-TNFRSF11B', 'ETV6-drive-Leukemia, Myeloid, Acute', 'CFTR-play-Dinoprostone', 'Leukemia-drive-RUNX1', 'RUNX1-drive-Leukemia, Myeloid, Acute', 'SIRT1-governed-Mitochondrial Diseases', 'Neurodegenerative Diseases-caused-NPC2', 'Neurodegenerative Diseases-caused-NPC1', 'TP53-retain-VIM', 'TP53-express-Infections', 'VIM-express-Infections', 'Sepharose-supplemented-EGF', 'HMMR-associated-Hearing Loss', 'Hearing Loss-associated-HMMR', 'COL5A1-associated-Hearing Loss', 'Hearing Loss-associated-COL5A1', 'RAPGEF3-associated-Hearing Loss', 'Hearing Loss-associated-RAPGEF3', 'ATF3-promote-MMP13', 'ATF3-promote-RUNX2', 'ATF3-promote-Breast Neoplasms', 'Osteopetrosis-ameliorate-Bone Diseases', 'NFKB2-show-Osteopetrosis', 'NFKB2-ameliorate-Bone Diseases', 'CD151-destabilize-Neoplasms', 'CCNE1-associated-Retinoblastoma', 'Retinoblastoma-associated-CCNE1', 'TFDP2-associated-Retinoblastoma', 'Retinoblastoma-associated-TFDP2', 'CCND3-associated-Retinoblastoma', 'Retinoblastoma-associated-CCND3', 'Osteogenesis Imperfecta-attributed-BGLAP', 'Osteogenesis Imperfecta-attributed-SP7', 'E2F4-associated-Retinoblastoma', 'Retinoblastoma-associated-E2F4', 'Osteogenesis Imperfecta-attributed-RUNX2', 'SLC7A11-treated-Capsaicin', 'GPX4-treated-Capsaicin', 'LEP-correlated-INS', 'Neoplasms-induce-Vision Disorders', 'LEP-correlated-Obesity, Abdominal', 'Neoplasms-induce-PTEN', 'MOB1A-involved-YAP1', 'MOB1A-involved-Neoplasms', 'MT-CO2-down-regulate-ROCK2', 'EZH2-down-regulate-ROCK2', 'STMN1-down-regulate-ROCK2', 'Carcinoma, Hepatocellular-decrease-MT-CO2', 'Carcinoma, Hepatocellular-decrease-EZH2', 'Carcinoma, Hepatocellular-block-STMN1', 'ZPR1-increase-SMN1', 'ZPR1-promote-Muscular Atrophy, Spinal', 'SLC2A4-regulate-INS', 'INS-stimulate-SLC2A4', 'INS-know-SLC2A4', 'SLC2A4-know-Glucose', 'Glucose-regulate-INS', 'Glucose-know-SLC2A4', 'Niemann-Pick Disease, Type C-caused-NPC1', 'Heredodegenerative Disorders, Nervous System-caused-NPC1', 'Niemann-Pick Disease, Type C-caused-NPC2', 'Heredodegenerative Disorders, Nervous System-caused-NPC2', 'Death-facilitate-BAX', 'Lymphoma-identified-CD2', 'Lymphoma-identified-CD5', 'Lymphoma-identified-CD7', 'ATM-include-Hereditary Breast and Ovarian Cancer Syndrome', 'TP53-include-Hereditary Breast and Ovarian Cancer Syndrome', 'MLH1-include-Hereditary Breast and Ovarian Cancer Syndrome', 'PMS2-include-Hereditary Breast and Ovarian Cancer Syndrome', 'PTEN-include-Hereditary Breast and Ovarian Cancer Syndrome', 'MSH3-include-Hereditary Breast and Ovarian Cancer Syndrome', 'PMS1-include-Hereditary Breast and Ovarian Cancer Syndrome', 'MSH2-include-Hereditary Breast and Ovarian Cancer Syndrome', 'IRF1-upregulate-ZEB1', 'MSH6-include-Hereditary Breast and Ovarian Cancer Syndrome', 'IRF1-Silencing-Stomach Neoplasms', 'IRF1-induce-Stomach Neoplasms', 'BRCA1-include-Hereditary Breast and Ovarian Cancer Syndrome', 'ZEB1-Silencing-Stomach Neoplasms', 'ZEB1-induce-Stomach Neoplasms', 'BRCA2-include-Hereditary Breast and Ovarian Cancer Syndrome', 'PARK7-include-Parkinson Disease', 'LRRK2-include-Parkinson Disease', 'PINK1-include-Parkinson Disease', 'Neoplasms-lead-RANBP2', 'Neoplasms-lead-ALK', 'EGR2-include-NFATC1', 'LCK-include-NFATC1', 'Leukemia, Lymphoid-consist-NFATC1', 'Leukemia, Lymphoid-consist-EGR2', 'Leukemia, Lymphoid-consist-LCK', 'Acromegaly-caused-Pituitary Neoplasms', 'Genetic Diseases, Inborn-caused-Pituitary Neoplasms', 'SLTM-mediate-Breast Neoplasms', 'Acromegaly-characterized-GH1', 'Genetic Diseases, Inborn-characterized-GH1', 'MDM2-increase-Breast Neoplasms', 'MYC-increase-Breast Neoplasms', 'TOP1-increase-Breast Neoplasms', 'DEAF1-contribute-TP53', 'SIRT1-increased-Multiple Chronic Conditions', 'Lung Neoplasms-contribute-DEAF1', 'DEAF1-lead-Neoplasms', 'ITGB4-promote-Glioblastoma', 'Thrombocytopenia-rescued-BAK1', 'Glioblastoma-rescue-ITGB4', 'Thrombocytopenia-rescued-BAX', 'Glioblastoma-rescue-AKT1', 'PRDX5-found-Hermanski-Pudlak Syndrome', 'CAT-found-Hermanski-Pudlak Syndrome', 'GSR-found-Hermanski-Pudlak Syndrome', 'Prostatic Neoplasms-treated-NUAK2', 'Neoplasms-improve-Lung Neoplasms', 'Neoplasms-improve-EGFR', 'BYSL-decrease-Neoplasms', 'RIOK2-decrease-Neoplasms', 'Kidney Failure, Chronic-carry-RARRES2', 'Kidney Failure, Chronic-carry-SERPINA12', 'Kidney Failure, Chronic-carry-rs17173608', 'Kidney Failure, Chronic-carry-rs2236242', 'ASXL1-carry-Cell Transformation, Viral', 'SRSF2-carry-Cell Transformation, Viral', 'EZH2-carry-Cell Transformation, Viral', 'E2F2-studied-Lung Neoplasms', 'ADGRE2-studied-Lung Neoplasms', 'Heparin-Regulated-CCL5', 'E2F2-expressed-Adenocarcinoma', 'CCL5-remain-COL18A1', 'Huntington Disease-Regulated-CCL5', 'PAH-pseudophosphorylate-MAPT', 'Enoxaparin-remain-Heparin', 'rs63750424-pseudophosphorylate-MAPT', 'Enoxaparin-remain-COL18A1', 'COL18A1-remain-Heparin', 'CCL5-increase-Enoxaparin', 'CCL5-remain-Heparin', 'BCL2-involved-Lymphoma', 'TP53-involved-Lymphoma', 'PIN1-maintain-Heart Arrest', 'Huntington Disease-remain-Heparin', 'BTG2-maintain-Heart Arrest', 'NODAL-regulate-LIF', 'NODAL-regulate-Glioma', 'Glioma-regulate-LIF', 'CCL28-altered-Hypertension, Pulmonary', 'PMAIP1-appear-Diabetes Mellitus, Type 2', 'CFD-altered-Hypertension, Pulmonary', 'PARL-appear-Diabetes Mellitus, Type 2', 'INS-appear-Diabetes Mellitus, Type 2', 'GLIPR1-appear-Diabetes Mellitus, Type 2', 'SMARCD3-appear-Diabetes Mellitus, Type 2', 'STAT2-appear-Diabetes Mellitus, Type 2', 'AKT1-appear-Diabetes Mellitus, Type 2', 'SOX2-detected-Stomach Neoplasms', 'ALDH1A1-detected-Stomach Neoplasms', 'Hypertension, Pulmonary-associated-Pulmonary Disease, Chronic Obstructive', 'Pulmonary Disease, Chronic Obstructive-associated-Hypertension, Pulmonary', 'AGRP-expressed-Pulmonary Disease, Chronic Obstructive', 'AGRP-expressed-Hypertension', 'AGRP-expressed-Hypertension, Pulmonary', 'CCL28-expressed-Pulmonary Disease, Chronic Obstructive', 'CCL28-expressed-Hypertension', 'CCL28-expressed-Hypertension, Pulmonary', 'Muscular Atrophy, Spinal-up-regulate-SMN1', 'LDHA-upregulated-LDHB', 'Metabolic Diseases-upregulated-LDHB', 'LDHB-upregulated-Neoplasms', 'Kidney Diseases-co-transfected-FEZ1', 'Kidney Diseases-co-transfected-NDEL1', 'Kidney Diseases-co-transfected-PDE4B', 'Kidney Diseases-co-transfected-DISC1', 'PKD2-occur-PKD1', 'Renal Insufficiency, Chronic-occur-Kidney Failure, Chronic', 'Renal Insufficiency, Chronic-occur-PKD2', 'Kidney Failure, Chronic-occur-PKD2', 'PKD2-occur-Hypertension', 'Renal Insufficiency, Chronic-occur-PKD1', 'Kidney Failure, Chronic-compare-PKD1', 'Kidney Failure, Chronic-occur-PKD1', 'PKD1-occur-Hypertension', 'MMP2-show-Renal Insufficiency, Chronic', 'TIMP1-show-Renal Insufficiency, Chronic', 'MMP2-mediate-Fibrosis', 'MMP7-mediate-Fibrosis', 'TIMP1-mediate-Fibrosis', 'Inflammation-modulate-Proteostasis Deficiencies', 'Inflammation-modulate-Neoplasms', 'Proteostasis Deficiencies-modulate-Neoplasms', 'Hypoxia-suppress-Neoplasms', 'Hypoxia-inhibit-CA9', 'Hypoxia-inhibit-VEGFA', 'TLR4-encountered-Gastroesophageal Reflux', 'TRPV1-encountered-Gastroesophageal Reflux', 'Neoplasms-emerge-HGF', 'Neoplasms-emerge-SLTM', 'RELA-follow-Kidney Diseases', 'Kidney Diseases-treat-KL', 'BRAF-potentiate-MITF', 'rs113488022-potentiate-MITF', 'SIRT1-parallel-TP53', 'Colorectal Neoplasms-directed-VEGFA', 'SIRT1-parallel-Neoplasms', 'TNFRSF1A-protect-Death', 'Death-mediated-BCL2', 'TNFRSF1B-protect-Death', 'Necrosis-implicated-Ascites', 'IL6-implicated-Ascites', 'TNF-implicated-Ascites', 'UVRAG-mutated-Colorectal Neoplasms', 'INS-restored-ADIPOQ', 'EGFR-affected-Carcinoma, Pancreatic Ductal', 'CCND1-affected-Carcinoma, Pancreatic Ductal', 'Insulin Resistance-restored-ADIPOQ', 'AKT2-associated-Gout', 'Gout-associated-AKT2', 'AKT2-modulate-Gout', 'FOXO3-associated-Gout', 'Gout-associated-FOXO3', 'FOXO3-modulate-Gout', 'EGFR-become-Lung Neoplasms', 'EGFR-become-Carcinoma, Non-Small-Cell Lung', 'ALK-become-Lung Neoplasms', 'ALK-become-Carcinoma, Non-Small-Cell Lung', 'CD163-associated-Neoplasms', 'Neoplasms-associated-CD163', 'SELL-induced-Lipopolysaccharides', 'BRCA1-estimated-Breast Neoplasms', 'BRCA2-estimated-Breast Neoplasms', 'Obesity-reduced-Hyperinsulinism', 'GGH-reduced-Obesity', 'ADAM10-enhance-NOTCH2', 'Neoplasms-enhance-NOTCH2', 'Neoplasms-recruit-ADAM10', 'BCL2-relate-Death', 'MCL1-relate-Death', 'BCL2-parallel-MCL1', 'BCL2-differ-Death', 'BCL2-inhibit-Death', 'Death-promote-MCL1', 'Acromegaly-associated-Death', 'Death-associated-Acromegaly', 'Acromegaly-associated-Neoplasms', 'Neoplasms-associated-Acromegaly', 'Glucose-mediated-SLC2A1', 'Glucose-mediated-SLC2A4', 'Acromegaly-attain-GGH', 'GGH-associated-Death', 'Death-associated-GGH', 'DEK-detected-FBXW7', 'DEK-detected-Colorectal Neoplasms', 'Sleep Disorders, Circadian Rhythm-consider-ESR1', 'Sleep Disorders, Circadian Rhythm-consider-PIK3CA', 'NEFL-diagnosed-Alzheimer Disease', 'GFAP-diagnosed-Alzheimer Disease', 'PTEN-reported-FBXW7', 'Fibrosis-include-Metabolic Diseases', 'TP53-reported-FBXW7', 'FBXW7-reported-Neoplasms', 'SIRT3-documented-Lung Diseases', 'PELI1-treat-Lymphoma', 'BCL6-treat-Lymphoma', 'SIRT6-documented-Lung Diseases', 'NR2E1-known-CD46', 'Glioblastoma-include-Brain Neoplasms', 'CD46-initiate-Brain Neoplasms', 'CD46-initiate-Glioblastoma', 'NR2E1-initiate-Brain Neoplasms', 'NR2E1-initiate-Glioblastoma', 'Glioblastoma-correlate-PROM1', 'Glioblastoma-correlate-STAT3', 'NFKB1-promote-MAPK9', 'NFKB1-promote-Inflammation', 'NFKB1-activate-Fibrosis', 'MAPK9-promote-Inflammation', 'Heart Arrest-increase-CEBPD', 'ABL1-increase-WIPI1', 'WIPI1-increase-Abetalipoproteinemia', 'Death-associated-BCHE', 'BCHE-associated-Death', 'Neoplasms-show-MYC', 'IL1B-associated-Infections', 'Infections-associated-IL1B', 'IL12B-associated-Infections', 'Infections-associated-IL12B', 'Kidney Diseases-caused-COL4A3', 'Nephritis, Hereditary-associated-Kidney Failure, Chronic', 'Kidney Failure, Chronic-associated-Nephritis, Hereditary', 'KMT2A-show-GATA4', 'Nephritis, Hereditary-caused-COL4A4', 'Kidney Diseases-caused-COL4A4', 'COL4A4-associated-Kidney Failure, Chronic', 'Kidney Failure, Chronic-associated-COL4A4', 'Nephritis, Hereditary-caused-COL4A3', 'COL4A3-associated-Kidney Failure, Chronic', 'Kidney Failure, Chronic-associated-COL4A3', 'MSTN-inhibit-SMAD2', 'MSTN-inhibit-Heart Arrest', 'CXCR4-involved-Neoplasms', 'CXCL12-involved-Neoplasms', 'CXCR4-expressed-Neoplasms', 'PROM1-expressed-Neoplasms', 'ZFP14-correlated-HOXA1', 'Neoplasms-correlated-HOXA1', 'NANOG-suggested-NANOGP8', 'NANOG-suggested-Neoplasms', 'NANOG-promote-Neoplasms', 'NANOGP8-suggested-Neoplasms', 'NANOGP8-promote-Neoplasms', 'IL10-associated-Hypothalamic Neoplasms', 'Hypothalamic Neoplasms-associated-IL10', 'Neoplasms-include-Glioblastoma', 'Neoplasms-originate-Glioblastoma', 'TF-driven-HFE', 'Death-investigate-TF', 'SMN1-carry-SMN2', 'Death-driven-HFE', 'Muscular Atrophy, Spinal-correct-SMN2', 'Cardiovascular Abnormalities-hyperphosphorylate-MAPT', 'Cardiovascular Abnormalities-hyperphosphorylate-CDK5', 'AK1-induced-MAPT', 'AK1-induced-PRKAB1', 'PRKAB1-increase-Neurodegenerative Diseases', 'AK1-induced-Neurodegenerative Diseases', 'AK1-contribute-Neurodegenerative Diseases', 'SIRT1-stimulate-INS', 'Carcinoma, Squamous Cell-yield-TP53', 'TRAF3-lead-Lymphoma', 'TRAF2-lead-Lymphoma', 'SIRT1-stimulate-Diabetes Mellitus, Type 1', 'Inflammation-regulate-Obesity', 'Inflammation-regulate-Fibrosis', 'Inflammation-regulate-Acute Kidney Injury', 'Polycythemia Vera-express-Thrombocythemia, Essential', 'Polycythemia Vera-express-Myeloproliferative Disorders', 'Thrombocythemia, Essential-express-Myeloproliferative Disorders', 'Polycythemia Vera-expected-CALR', 'Thrombocythemia, Essential-express-CALR', 'JAK2-expected-Polycythemia Vera', 'JAK2-express-Thrombocythemia, Essential', 'VPS26A-observed-Parkinson Disease', 'VPS35-observed-Parkinson Disease', 'SERPINB3-down-regulated-OR2A4', 'SERPINB3-down-regulated-LGR5', 'OR2A4-down-regulated-Diabetic Foot', 'LGR5-down-regulated-Diabetic Foot', 'SERPINB3-down-regulated-Diabetic Foot', 'DICER1-evaluated-Esophageal Squamous Cell Carcinoma', 'DDX20-evaluated-Esophageal Squamous Cell Carcinoma', 'XPO5-evaluated-Esophageal Squamous Cell Carcinoma', 'GEMIN4-evaluated-Esophageal Squamous Cell Carcinoma', 'TNRC6B-evaluated-Esophageal Squamous Cell Carcinoma', 'RAN-evaluated-Esophageal Squamous Cell Carcinoma', 'ITGB4-associated-Pulmonary Atresia', 'Pulmonary Atresia-associated-ITGB4', 'rs3742330-evaluated-Esophageal Squamous Cell Carcinoma', 'ITGB4-associated-Epidermolysis Bullosa', 'Epidermolysis Bullosa-associated-ITGB4', 'rs14035-evaluated-Esophageal Squamous Cell Carcinoma', 'ITGA6-associated-Pulmonary Atresia', 'Pulmonary Atresia-associated-ITGA6', 'ITGA6-associated-Epidermolysis Bullosa', 'Epidermolysis Bullosa-associated-ITGA6', 'rs11077-evaluated-Esophageal Squamous Cell Carcinoma', 'rs9623117-evaluated-Esophageal Squamous Cell Carcinoma', 'rs197412-evaluated-Esophageal Squamous Cell Carcinoma', 'rs2740348-evaluated-Esophageal Squamous Cell Carcinoma', 'Shock-blunted-EPO', 'Neoplasms-resected-PROM1', 'PROM1-analyzed-Neoplasms', 'Neoplasms-resected-KLK3', 'Galactose-increase-ADAM17', 'PROM1-show-Prostatic Neoplasms', 'GRHL2-show-Prostatic Neoplasms', 'Galactose-reduce-CASP3', 'Galactose-reduce-Phosphatidylserines', 'PROM1-observed-Prostatic Neoplasms', 'KLK3-observed-Prostatic Neoplasms', 'NGF-characterized-Intellectual Disability', 'Hypohidrosis-caused-NTRK1', 'CSF3R-affect-CSF3', 'CSF3-affect-Leukemia', 'CSF3R-affect-Leukemia', 'Necrosis-demonstrate-Diabetes Mellitus', 'Necrosis-counteract-INS', 'INS-demonstrate-Diabetes Mellitus', 'FBXL2-expressed-CCND2', 'FBXL2-expressed-Leukemia, Myeloid, Acute', 'KITLG-ubiquitinate-CCND2', 'TNFRSF11B-measured-Thalassemia', 'KITLG-termed-FBXL2', 'FBXL2-expressed-Precursor Cell Lymphoblastic Leukemia-Lymphoma', 'FBXL2-ubiquitinate-CCND2', 'CCND2-expressed-Leukemia, Myeloid, Acute', 'KITLG-lead-Heart Arrest', 'CCND2-lead-Heart Arrest', 'CCND2-expressed-Precursor Cell Lymphoblastic Leukemia-Lymphoma', 'FBXL2-lead-Heart Arrest', 'TNFSF11-implicated-Osteoporosis', 'TNFRSF11B-implicated-Osteoporosis', 'Thalassemia-complicated-Osteoporosis', 'Bone Diseases, Metabolic-suffer-Thalassemia', 'Osteoporosis-suffer-Thalassemia', 'TNFSF11-become-Bone Diseases, Metabolic', 'TNFSF11-become-Osteoporosis', 'TNFSF11-become-Thalassemia', 'TNFRSF11B-become-Bone Diseases, Metabolic', 'TNFRSF11B-become-Osteoporosis', 'TNFRSF11B-suffer-Thalassemia', 'TNFRSF11B-become-Thalassemia', 'TNFRSF11B-suffer-Bone Diseases, Metabolic', 'TNFRSF11B-suffer-Osteoporosis', 'Loeys-Dietz Syndrome-caused-TGFBR2', 'Loeys-Dietz Syndrome-caused-TGFBR1', 'SMN1-remain-SMN2', 'Neoplasms-observed-Lymphoma', 'SMN1-result-Muscular Atrophy, Spinal', 'Muscular Atrophy, Spinal-result-SMN1', 'Muscular Atrophy, Spinal-remain-SMN2', 'CBX7-identify-Neoplasms', 'CBX7-linked-Neoplasms', 'BUB1-become-Aneuploidy', 'CBX7-observed-Lymphoma', 'TP53-become-Aneuploidy', 'CBX7-expressed-Lymphoma', 'CBX7-expressed-Neoplasms', 'Hyperlipoproteinemia Type II-diagnosed-Coronary Artery Disease', 'Hyperlipoproteinemia Type II-diagnosed-Atherosclerosis', 'Genetic Diseases, Inborn-base-Coronary Artery Disease', 'Genetic Diseases, Inborn-diagnosed-Coronary Artery Disease', 'Genetic Diseases, Inborn-base-Atherosclerosis', 'Genetic Diseases, Inborn-diagnosed-Atherosclerosis', 'FOXO3-show-Death', 'Neoplasms-maintain-Leukemia, Myelogenous, Chronic, BCR-ABL Positive', 'AXL-increase-Neoplasms', 'AXL-maintain-Neoplasms', 'TP53-inhibit-Multiple Chronic Conditions', 'BOP1-inhibit-Multiple Chronic Conditions', 'Brain Injuries-express-ACVR2A', 'Multiple Sclerosis-express-ACVR2A', 'Neoplasm Metastasis-show-SOD2', 'Intestinal Neoplasms-expressed-USP28', 'Neoplasm Metastasis-show-GPX1', 'Leukemia, Hairy Cell-express-ITGAX', 'Leukemia, Hairy Cell-express-ITGAE', 'Leukemia, Hairy Cell-express-IL3RA', 'TNFRSF12A-named-TNFSF12', 'TNFRSF12A-encode-Necrosis', 'Necrosis-named-TNFSF12', 'TNFSF12-result-Glioma', 'TNFRSF12A-result-Glioma', 'CDK19-fail-CDK8', 'CDK19-rescue-CDK8', 'rs1236246272-rescue-CDK8', 'CXCL12-involved-Medulloblastoma', 'CXCR4-involved-Medulloblastoma', 'KLF8-generate-AKT1', 'Infections-overexpress-KLF8', 'Infections-generate-AKT1', 'Amyotrophic Lateral Sclerosis-increase-NES', 'Amyotrophic Lateral Sclerosis-increase-GFAP', 'Breast Neoplasms--characterized-BRCA2', 'Breast Neoplasms--characterized-BRCA1', 'Death-trigger-Ataxia', 'Death-trigger-Intellectual Disability', 'Ataxia-linked-AFF3', 'Intellectual Disability-linked-AFF3', 'Death-linked-AFF2', 'Ataxia-linked-AFF2', 'Intellectual Disability-linked-AFF2', 'SIRT7-interact-HDAC3', 'Osteoporosis-include-Neoplasms', 'SIRT7-repress-Carcinoma, Hepatocellular', 'SOST-include-Neoplasms', 'DKK1-include-Neoplasms', 'TOX3-play-Polycystic Ovary Syndrome', 'THADA-play-Polycystic Ovary Syndrome', 'DENND1A-play-Polycystic Ovary Syndrome', 'JAK2-occur-Thrombocythemia, Essential', 'CALR-occur-Thrombocythemia, Essential', 'MPL-occur-Thrombocythemia, Essential', 'MSR1-associated-Neoplasms', 'Neoplasms-associated-MSR1', 'IGF1R-upregulated-Neoplasms', 'PTEN-modified-IGF2', 'Neoplasms-modified-IGF2', 'PTEN-reduced-Neoplasms', 'BCL2L11-seen-Bone Marrow Diseases', 'Malabsorption Syndromes-include-Nervous System Diseases', 'BCL2L11-seen-Shock, Septic', 'INS-include-Nervous System Diseases', 'GGH-implicate-Hypertrophy', 'Hypertelorism-reported-Cleft Palate', 'SMAD3-reported-Hypertelorism', 'SMAD3-reported-Cleft Palate', 'TGFB3-reported-Hypertelorism', 'ADIPOQ-prevent-Vascular Calcification', 'TGFB3-reported-Cleft Palate', 'ITLN1-prevent-Vascular Calcification', 'Atherosclerosis-suppress-Inflammation', 'ADIPOQ-prevent-Atherosclerosis', 'NANOG-include-Atrial Fibrillation', 'ADIPOQ-suppress-Inflammation', 'POU5F1-include-Atrial Fibrillation', 'ITLN1-prevent-Atherosclerosis', 'LIN28A-include-Atrial Fibrillation', 'ITLN1-suppress-Inflammation', 'NANOG-preserve-SOX2', 'NANOG-maintain-POU5F1', 'NANOG-identified-Atrial Fibrillation', 'NANOG-overexpress-Papilledema', 'VEGFA-assess-Death', 'VEGFA-assess-Peripheral Arterial Disease', 'Amyotrophic Lateral Sclerosis-encompass-VAPB', 'Amyotrophic Lateral Sclerosis-encompass-UBQLN2', 'Amyotrophic Lateral Sclerosis-encompass-VCP', 'TOX-associated-FCRL3', 'FCRL3-associated-TOX', 'CD164-co-expressed-KIR3DL2', 'CD164-co-expressed-Neoplasms', 'KIR3DL2-co-expressed-Neoplasms', 'ADIPOQ-reverse-Obesity', 'LEP-reverse-Obesity', 'Neoplasms-assessed-ADIPOQ', 'Neoplasms-assessed-LEP', 'HUS1-involved-Fragile X Syndrome', 'CHEK1-involved-Fragile X Syndrome', 'SREBF1-involved-Fatty Acids', 'MAPK1-involved-Fatty Acids', 'SREBF2-involved-Fatty Acids', 'PTEN-involved-Fatty Acids', 'GGH-cause-Edema', 'GGH-cause-Ankylosis', 'Heart Failure-expressed-CCL3', 'Ventricular Fibrillation-expressed-CCL3', 'NRG1-reduced-Neurodegenerative Diseases', 'MAPT-reduced-Neurodegenerative Diseases', 'BDNF-reduced-Neurodegenerative Diseases', 'AKT1-protect-Amyotrophic Lateral Sclerosis', 'UBA5-activate-UFM1', 'TNFRSF10B-determined-AKT1', 'TNFRSF10B-mediate-Glioma', 'Glioma-determined-AKT1', 'CYP19A1-associated-APOE', 'APOE-associated-CYP19A1', 'rs4646-associated-APOE', 'APOE-associated-rs4646', 'CYP19A1-associated-rs4646', 'rs4646-associated-CYP19A1', 'CYP19A1-contribute-Alzheimer Disease', 'Alzheimer Disease-associated-rs4646', 'rs4646-associated-Alzheimer Disease', 'Necrosis-induce-Neoplasms', 'Necrosis-induce-Death', 'Necrosis-investigated-Neoplasms', 'Death-investigated-Neoplasms', 'Necrosis-induce-TNFRSF10B', 'Neoplasms-induce-TNFRSF10B', 'TNFRSF10B-investigated-Neoplasms', 'Necrosis-induce-TNFRSF10A', 'Neoplasms-induce-TNFRSF10A', 'TNFRSF10A-investigated-Neoplasms', 'CDKN2A-contribute-CDKN2B', 'CDKN2A-contribute-Acute Kidney Injury', 'CD28-lead-Arbovirus Infections', 'Neoplasms-reduce-APC', 'Ionomycin-cause-ATG5', 'HTR2A-noted-PRODH', 'COMT-noted-PRODH', 'HTR2A-correlated-Carcinogenesis', 'Carcinogenesis-noted-PRODH', 'COMT-correlated-Carcinogenesis', 'COL6A1-result-Neurologic Manifestations', 'COL6A2-result-Neurologic Manifestations', 'COL6A3-result-Neurologic Manifestations', 'AKR1B1-lost-Neoplasms', 'BRF1-lost-Neoplasms', 'Heart Arrest-activate-CCNB1', 'CSN2-show-Neoplasms', 'BRF1-show-Neoplasms', 'CFHR3-detected-CFHR1', 'CFHR3-detected-Macular Degeneration', 'CFHR1-detected-Macular Degeneration', 'Carcinoma, Hepatocellular-reveal-KDR', 'Carcinoma, Hepatocellular-reveal-EGFR', 'Carcinoma, Hepatocellular-reveal-MTOR', 'Carcinoma, Hepatocellular-reveal-PDGFRB', 'Cystic Fibrosis-display-IL5', 'Cystic Fibrosis-display-IL17A', 'HIV Infections-activate-AKT1', 'CCL17-augmented-Pseudomonas Infections', 'Hyperparathyroidism, Secondary-observed-LEP', 'IL17A-augmented-Pseudomonas Infections', 'Hyperparathyroidism, Secondary-observed-ADIPOQ', 'HIV Infections-reflect-PTEN', 'TAT-bind-TP53', 'Situs Inversus-bind-TP53', 'CDKN2A-associated-CDK6', 'CDK6-associated-CDKN2A', 'CUX1-regulate-CDKN2A', 'MTAP-associated-CDKN2A', 'CDKN2A-associated-MTAP', 'CUX1-bind-CDK4', 'MTAP-associated-CDK6', 'CDK6-associated-MTAP', 'Mesothelioma-harbour-Neoplasms', 'CUX1-bind-CDKN2A', 'CDKN2A-target-CDK4', 'CDKN2A-target-CDK6', 'Mesothelioma-harbour-CDKN2A', 'Mesothelioma-harbour-CDK6', 'CDKN2A-suppress-Mesothelioma', 'Mesothelioma-target-CDK4', 'rs1537371-regulate-CDKN2A', 'MTAP-associated-Neoplasms', 'Neoplasms-associated-MTAP', 'Mesothelioma-target-CDK6', 'Inflammation-associated-Sjogren-Larsson Syndrome', 'Sjogren-Larsson Syndrome-associated-Inflammation', 'TCN2-contribute-Osteoporosis', 'INS-underlie-INSR', 'INSR-underlie-INS', 'INSR-related-INS', 'INSR-include-INS', 'SLC19A1-contribute-Osteoporosis', 'CD320-contribute-Osteoporosis', 'RB1-found-Prostatic Neoplasms', 'SLC19A2-encode-Osteoporotic Fractures', 'PTEN-found-Prostatic Neoplasms', 'CD320-encode-Osteoporotic Fractures', 'TCN2-encode-Osteoporotic Fractures', 'TP53-found-Prostatic Neoplasms', 'SLC19A1-encode-Osteoporotic Fractures', 'Neoplasms-known-DDIT3', 'EGFR-escape-Neoplasms', 'GAB1-underscore-Neoplasms', 'SHC1-underscore-Neoplasms', 'LRRK2-studied-SLC18A2', 'LRRK2-scanned-SLC6A3', 'SLC18A2-reduced-LRRK2', 'SLC18A2-manifest-Parkinson Disease', 'Parkinson Disease-reduced-LRRK2', 'PLAUR-observed-Neoplasms', 'PLAU-observed-Neoplasms', 'ERBB2-target-Kidney Diseases', 'ERBB2-activate-Neoplasms', 'EGFR-activate-Neoplasms', 'HTRA2-truncate-BID', 'DIABLO-truncate-BID', 'FXN-increase-EPO', 'Drug-Related Side Effects and Adverse Reactions-increase-EPO', 'Drug-Related Side Effects and Adverse Reactions-increase-FXN', 'EPO-evaluate-TFRC', 'EPO-evaluate-Spherocytosis, Hereditary', 'TFRC-measure-Spherocytosis, Hereditary', 'AGRN-implicated-Sarcopenia', 'AGRN-associated-Sarcopenia', 'Sarcopenia-associated-AGRN', 'PRSS12-implicated-Sarcopenia', 'PRSS12-associated-Sarcopenia', 'Sarcopenia-associated-PRSS12', 'ZFAND2A-identify-HSF1', 'ZFAND2A-protect-Melanoma', 'SMN1-enhance-ZPR1', 'ZPR1-enhance-SMN2', 'ZPR1-lead-Muscular Atrophy, Spinal', 'SMN2-lead-Muscular Atrophy, Spinal', 'ZFAND2A-interact-BIRC3', 'BIRC3-regulate-Melanoma', 'ZFAND2A-regulate-Melanoma', 'Melanoma-link-BIRC3', 'Neoplasms-underlie-EGFR', 'Neoplasms-underlie-VEGFA', 'Neoplasms-interfere-Death', 'Neoplasms-interfere-KRT8', 'KRT8-interfere-Death', 'Neoplasms-interfere-KRT18', 'CRP-suggest-Infections', 'APOE-suggest-Infections', 'Glioma-rescued-MAP2K1', 'MYC-associated-Lung Neoplasms', 'Lung Neoplasms-associated-MYC', 'NEU1-associated-Lung Neoplasms', 'Lung Neoplasms-associated-NEU1', 'GRN-increase-C9orf72', 'Oligodendroglioma-vary-EGFR', 'Glioblastoma-vary-EGFR', 'Oligodendroglioma-vary-TP53', 'Glioblastoma-vary-TP53', 'GRN-increase-Alzheimer Disease', 'GRN-increase-Parkinson Disease', 'GRN-increase-Brain Diseases', 'GRN-exacerbate-Amyotrophic Lateral Sclerosis', 'GRN-exacerbate-Liver Neoplasms', 'SPRED2-result-Heart Failure', 'MAPK1-result-Heart Failure', 'AKT1-display-FOXO1', 'AKT1-display-Neoplasms', 'Melanoma-associated-CDH1', 'CDH1-associated-Melanoma', 'Melanoma-associated-CDH3', 'CDH3-associated-Melanoma', 'Melanoma-associated-CITED1', 'CITED1-associated-Melanoma', 'Melanoma-associated-MC1R', 'MC1R-associated-Melanoma', 'Melanoma-associated-PAX3', 'PAX3-associated-Melanoma', 'MTOR-reduce-AKT1', 'Melanoma-associated-OCA2', 'OCA2-associated-Melanoma', 'MTOR-induce-Retinoblastoma', 'Retinoblastoma-contain-Neoplasms', 'Retinoblastoma-stained-Neoplasms', 'Retinoblastoma-use-Neoplasms', 'Retinoblastoma-stained-RPS6', 'Neoplasms-stained-RPS6', 'Retinoblastoma-stained-FOXO1', 'Neoplasms-stained-FOXO1', 'Retinoblastoma-stained-AKT1', 'Neoplasms-stained-AKT1', 'GDNF-transplanted-Amyotrophic Lateral Sclerosis', 'NCAM1-transplanted-Amyotrophic Lateral Sclerosis', 'Weight Loss-observed-SIRT3', 'Weight Loss-observed-SIRT6', 'Weight Loss-observed-SIRT1', 'TNF-include-Inflammation', 'IL23A-include-Inflammation', 'Fatty Acids-activate-TRPV1', 'Fatty Acids-activate-TRPV2', 'ANK2-include-Parkinson Disease', 'ATP10B-include-Parkinson Disease', 'DNAH1-include-Parkinson Disease', 'CHMP1A-include-Parkinson Disease', 'STAB1-include-Parkinson Disease', 'UQCRC1-include-Parkinson Disease', 'TOMM22-include-Parkinson Disease', 'SPTBN1-include-Parkinson Disease', 'KIF21B-include-Parkinson Disease', 'SLC25A39-include-Parkinson Disease', 'KIF24-include-Parkinson Disease', 'GIPC1-include-Parkinson Disease', 'HEXB-composed-G(M2) Ganglioside', 'TNFSF12-upregulated-Neoplasms', 'Arthritis, Rheumatoid-associated-PRTN3', 'PRTN3-associated-Arthritis, Rheumatoid', 'TNFRSF12A-upregulated-Neoplasms', 'Arthritis, Rheumatoid-associated-IL6', 'IL6-associated-Arthritis, Rheumatoid', 'Arthritis, Rheumatoid-associated-IL17A', 'IL17A-associated-Arthritis, Rheumatoid', 'CD8A-discuss-HIV Infections', 'CD4-discuss-HIV Infections', 'Neoplasms-caused-GLI1', 'GADD45A-appear-FOXO3', 'Heart Arrest-appear-FOXO3', 'GLI1-caused-Prostatic Neoplasms', 'ADM-involve-Heart Failure', 'ADIPOQ-involve-Heart Failure', 'Muscular Diseases-carry-TNFRSF1A', 'rs104895094-carry-Muscular Diseases', 'rs104895094-carry-Fever', 'SIRT6-suppress-MAPK1', 'SIRT6-downregulate-Thyroid Cancer, Papillary', 'Thyroid Cancer, Papillary-suppress-MAPK1', 'Neoplasms-control-GH1', 'FGF2-related-Neoplasms', 'Neoplasms-show-KIAA1549', 'FGF2-related-Lung Neoplasms', 'PIK3R1-related-Neoplasms', 'PIK3R1-related-Lung Neoplasms', 'Neoplasms-show-BRAF', 'FCGRT-induce-Inflammation', 'Neoplasms-show-rs113488022', 'CAV1-affect-Lung Neoplasms', 'JAK2-affect-Lung Neoplasms', 'HMGB1-induce-Inflammation', 'TJP1-affect-Lung Neoplasms', 'Mitochondrial Diseases-develop-Motor Neuron Disease', 'BDNF-affect-Lung Neoplasms', 'rs587777574-associated-CHCHD10', 'CHCHD10-associated-rs587777574', 'FGF2-affect-Lung Neoplasms', 'rs730880031-associated-CHCHD10', 'CHCHD10-associated-rs730880031', 'NCAM1-affect-Lung Neoplasms', 'PIK3R1-affect-Lung Neoplasms', 'CHCHD10-associated-Mitochondrial Diseases', 'Mitochondrial Diseases-associated-CHCHD10', 'IFNG-use-DNMT3A', 'IFNG-increase-DNMT3A', 'CHCHD10-develop-Motor Neuron Disease', 'DNMT3A-increase-Seizures', 'IFNG-use-Seizures', 'IFNG-increase-Seizures', 'rs587777574-develop-Motor Neuron Disease', 'rs730880031-develop-Motor Neuron Disease', 'ABCC4-reduce-GLI3', 'Neoplasms-reduce-ABCC4', 'Neoplasms-reduce-GLI3', 'Lipodystrophy-related-Acquired Immunodeficiency Syndrome', 'MTOR-result-Bleomycin', 'INS-related-Acquired Immunodeficiency Syndrome', 'MAPK1-result-Bleomycin', 'Bleomycin-result-VEGFA', 'Hemolysis-carry-SPTA1', 'Hemolysis-carry-ANK1', 'VIM-derived-Glioma', 'Hemolysis-carry-SLC4A1', 'Alzheimer Disease-identify-ADAMTS4', 'VPS37A-related-EGFR', 'Alzheimer Disease-identify-ADAM10', 'VPS37A-related-Breast Neoplasms', 'VPS37A-express-Breast Neoplasms', 'Alzheimer Disease-identify-BIN1', 'Glucose-result-CDH5', 'Glucose-result-NLGN1', 'OSGEP-associated-WDR73', 'WDR73-associated-OSGEP', 'OSGEP-associated-Nephrotic Syndrome', 'Nephrotic Syndrome-associated-OSGEP', 'Glucose-result-TNFAIP6', 'VPS37A-downregulate-EGFR', 'Breast Neoplasms-downregulate-EGFR', 'GGH-increase-Bone Diseases', 'VPS37A-inhibit-Breast Neoplasms', 'Alzheimer Disease-analyzed-MAPT', 'SORL1-analyzed-Alzheimer Disease', 'GH1-required-Acromegaly', 'SOD3-augmented-MIR195', 'CDK4-associated-CDKN2A', 'CDKN2A-associated-CDK4', 'Genetic Diseases, Inborn-caused-NPC2', 'Genetic Diseases, Inborn-caused-NPC1', 'Neoplasms-harbor-TP53', 'Neoplasms-harbor-ATRX', 'SRSF2-associated-Memory Disorders', 'Memory Disorders-associated-SRSF2', 'SRSF2-associated-Fibrosis', 'Fibrosis-associated-SRSF2', 'SRSF2-associated-Polycythemia Vera', 'Polycythemia Vera-associated-SRSF2', 'U2AF1-include-Thrombocythemia, Essential', 'ASXL1-associated-Memory Disorders', 'Memory Disorders-associated-ASXL1', 'ASXL1-impact-Mastocytosis, Systemic', 'ASXL1-associated-Fibrosis', 'Fibrosis-associated-ASXL1', 'ASXL1-impact-Hematologic Neoplasms', 'ASXL1-associated-Polycythemia Vera', 'Polycythemia Vera-associated-ASXL1', 'TET2-impact-Mastocytosis, Systemic', 'TET2-impact-Hematologic Neoplasms', 'RUNX1-impact-Mastocytosis, Systemic', 'ERCC6-caused-ERCC8', 'RUNX1-impact-Hematologic Neoplasms', 'EZH2-include-Thrombocythemia, Essential', 'JAK2-impact-Mastocytosis, Systemic', 'JAK2-impact-Hematologic Neoplasms', 'Cockayne Syndrome-characterized-ERCC6', 'Genetic Diseases, Inborn-characterized-ERCC6', 'SRSF2-impact-Mastocytosis, Systemic', 'Cockayne Syndrome-characterized-ERCC8', 'SRSF2-impact-Hematologic Neoplasms', 'Genetic Diseases, Inborn-characterized-ERCC8', 'ATM-used-TP53', 'TP53-detect-Leukemia, Lymphocytic, Chronic, B-Cell', 'ATM-used-Leukemia, Lymphocytic, Chronic, B-Cell', 'ATM-detect-Leukemia, Lymphocytic, Chronic, B-Cell', 'ATM-associated-TP53', 'TP53-associated-ATM', 'TP53-associated-Leukemia, Lymphocytic, Chronic, B-Cell', 'Leukemia, Lymphocytic, Chronic, B-Cell-associated-TP53', 'ATM-associated-Leukemia, Lymphocytic, Chronic, B-Cell', 'Leukemia, Lymphocytic, Chronic, B-Cell-associated-ATM', 'TSPO-associated-Neoplasms', 'Neoplasms-associated-TSPO', 'CDKN1A-include-TP53', 'TP53-bind-BRD7', 'PCDH7-include-TP53', 'Cardiovascular Diseases-needed-Acute Disease', 'Neoplasms-bind-BRD7', 'Cardiovascular Diseases-play-FABP4', 'ABCC3-regulated-TP53', 'Lung Neoplasms-represent-Neoplasms', 'ABCC3-drive-Carcinoma, Pancreatic Ductal', 'TP53-drive-Carcinoma, Pancreatic Ductal', 'Neoplasms-inhibit-MTOR', 'Lung Neoplasms-inhibit-MAPK1', 'LEP-induce-Anorexia', 'LEP-suppress-Cachexia', 'Neoplasms-inhibit-MAPK1', 'NPY-induce-Anorexia', 'TET2-control-Neoplasms', 'NPY-suppress-Cachexia', 'Ghrelin-induce-Anorexia', 'Lung Neoplasms-suppress-MAPK1', 'Neoplasms-suppress-MAPK1', 'CRP-needed-Acute Disease', 'CXCR6-reported-Arthritis, Rheumatoid', 'IGLL5-reported-Arthritis, Rheumatoid', 'CXCL11-reported-Arthritis, Rheumatoid', 'SHC1-activated-NFE2L2', 'CXCL13-reported-Arthritis, Rheumatoid', 'NFE2L2-activated-Leukemia, Erythroblastic, Acute', 'KLRK1-reported-Arthritis, Rheumatoid', 'GZMA-reported-Arthritis, Rheumatoid', 'SLAMF1-reported-Arthritis, Rheumatoid', 'SDC1-reported-Arthritis, Rheumatoid', 'IL15-reported-Arthritis, Rheumatoid', 'MS4A1-reported-Arthritis, Rheumatoid', 'LAMB1-carry-LAMB2', 'Nephrotic Syndrome-carry-LAMB2', 'SIRT6-promote-Necrosis', 'PRG2-altered-Ovarian Diseases', 'Heart Arrest-inhibit-CDK4', 'Heart Arrest-inhibit-CDK2', 'Heart Arrest-inhibit-CDK6', 'Ovarian Neoplasms-express-PRG2', 'Calcitriol-accompanied-SPRR1B', 'Calcitriol-stimulate-IVL', 'Neoplasms-characterized-Splenomegaly', 'Neoplasms-characterized-JAK2', 'Neoplasms-characterized-CALR', 'CLDN4-require-Neoplasms', 'CLDN8-require-Neoplasms', 'GABRB3-require-Neoplasms', 'Prostatic Neoplasms-associated-SPOP', 'SPOP-associated-Prostatic Neoplasms', 'Genetic Diseases, X-Linked-arise-Atrial Fibrillation', 'STAT3-inhibited-Diabetic Foot', 'FOXM1-inhibited-Diabetic Foot', 'Renal Insufficiency, Chronic-promote-Fibrosis', 'Renal Insufficiency, Chronic-promote-DKK3', 'DKK3-promote-Fibrosis', 'Seizures, Febrile-include-Epilepsy', 'Epilepsies, Myoclonic-include-Epilepsy', 'Leukemia, Myeloid, Acute-compare-NPM1', 'Leukemia, Myeloid, Acute-compare-CEBPA', 'Acromegaly-caused-GH1', 'AMH-reduced-BRCA1', 'AMH-reduced-Lymphoma', 'AMH-reduced-Breast Neoplasms', 'Lymphoma-reduced-BRCA1', 'Breast Neoplasms-reduced-BRCA1', 'Alzheimer Disease-increase-IDE', 'Alzheimer Disease-shown-MME', 'Alzheimer Disease-known-Parkinson Disease', 'Alzheimer Disease-shown-IDE', 'Alzheimer Disease-increase-MME', 'IL1B-mediate-Atherosclerosis', 'Alzheimer Disease-characterized-Parkinson Disease', 'Mucopolysaccharidosis II-blocked-Heparitin Sulfate', 'Mucopolysaccharidosis III-blocked-Heparitin Sulfate', 'Nerve Degeneration-characterized-Parkinson Disease', 'Mucopolysaccharidosis II-blocked-Dermatan Sulfate', 'Mucopolysaccharidosis III-blocked-Dermatan Sulfate', 'MAPT-characterized-Parkinson Disease', 'BCL2-improve-Parkinson Disease', 'Parkinson Disease-improve-GDNF', 'ID1-delay-Melanoma', 'PCNA-intercorrelated-TP53', 'PCNA-intercorrelated-Neoplasm Metastasis', 'TP53-correlated-PCNA', 'PCNA-evaluated-Neoplasms', 'TP53-correlated-Neoplasm Metastasis', 'TP53-evaluated-Neoplasms', 'LEP-related-Obesity', 'ADIPOQ-related-Obesity', 'MDM2-activate-TP53', 'AURKA-activate-TP53', 'MDM2-activate-Neoplasms', 'TP53-activate-Neoplasms', 'SDHB-lead-Paraganglioma', 'AURKA-activate-Neoplasms', 'BDNF-implicated-Spinal Cord Injuries', 'NTRK2-implicated-Spinal Cord Injuries', 'BRAF-include-Leukemia, Hairy Cell', 'BTK-include-Leukemia, Hairy Cell', 'Nucleosides-include-Leukemia, Hairy Cell', 'KCNH1-transfected-RB1', 'Uterine Cervical Neoplasms-transfected-RB1', 'GHRH-diagnose-Dwarfism, Pituitary', 'ABL2-diagnose-Dwarfism, Pituitary', 'GHRH-considered-Dwarfism, Pituitary', 'ABL2-considered-Dwarfism, Pituitary', 'Neoplasm Metastasis-show-EGFR', 'CRP-experience-Disease Progression', 'Neoplasm Metastasis-show-ERBB2', 'Neoplasm Metastasis-show-PTEN', 'SEC14L2-associated-TAP2', 'TAP2-associated-SEC14L2', 'Hereditary Breast and Ovarian Cancer Syndrome-associated-TAP2', 'TAP2-associated-Hereditary Breast and Ovarian Cancer Syndrome', 'BCL2L10-linked-Myelodysplastic Syndromes', 'IDH1-include-Leukemia, Myeloid, Acute', 'TET2-include-Leukemia, Myeloid, Acute', 'GATA2-include-Leukemia, Myeloid, Acute', 'IKZF1-include-Leukemia, Myeloid, Acute', 'rs371769427-include-Leukemia, Myeloid, Acute', 'Muscular Atrophy, Spinal-lost-SMN1', 'Muscular Atrophy, Spinal-lost-SMN2', 'Exostoses, Multiple Hereditary-found-Neoplasms', 'Exostoses, Multiple Hereditary-found-EXT1', 'Exostoses, Multiple Hereditary-found-EXT2', 'LCN2-increase-FGF23', 'LCN2-contribute-Heart Diseases', 'FGF23-contribute-Heart Diseases', 'Diabetes Mellitus-account-Bone Neoplasms', 'Diabetes Mellitus-account-Fractures, Bone', 'CACNA1C-explain-Epilepsy', 'Hypertension-associated-CD8A', 'CD8A-associated-Hypertension', 'CNR1-correlate-rs4680', 'Viremia-associated-Hypertension', 'Hypertension-associated-Viremia', 'FGF21-elevated-INS', 'FGF21-elevated-Obesity, Abdominal', 'FGF21-elevated-Diabetes Mellitus, Type 2', 'Neoplasms-recommended-RARG', 'Neoplasms-recommended-SLC28A3', 'FGF1-demonstrate-FGF21', 'FGF19-demonstrate-FGF1', 'Neoplasms-recommended-rs2229774', 'FGF1-improve-Glucose', 'Neoplasms-recommended-rs7853758', 'Neoplasms-recommended-rs17863783', 'FGF19-demonstrate-Glucose', 'Cardiomyopathies-associated-SCO2', 'SCO2-associated-Cardiomyopathies', 'Cardiomyopathies-associated-SCO1', 'SCO1-associated-Cardiomyopathies', 'PTHLH-related-PTH', 'HTT-rescued-RAB4A', 'HTT-result-Gait Disorders, Neurologic', 'PTH-evaluate-Neoplasms', 'RAB4A-rescued-Gait Disorders, Neurologic', 'KISS1-engage-GNRH1', 'Hypothalamic Neoplasms-engage-KISS1', 'RAB4A-derived-Huntington Disease', 'Huntington Disease-perturbed-HTT', 'PRKAA1-found-BDNF', 'PRKAA1-found-Ionomycin', 'RICTOR-calculated-Breast Neoplasms', 'MAP4K3-calculated-Breast Neoplasms', 'PTPRF-calculated-Breast Neoplasms', 'PRKAR2B-calculated-Breast Neoplasms', 'STAT3-identify-Melanoma', 'Neoplasms-express-INSR', 'Neoplasms-express-INS', 'ID1-decrease-NEUROD6', 'Melanoma-present-STAT3', 'Neoplasm Metastasis-present-STAT3', 'MYT1L-result-NEUROD6', 'MYT1L-decrease-NEUROD6', 'ID1-result-TCF4', 'MYT1L-result-ID1', 'MYT1L-result-ID3', 'MYT1L-result-TCF4', 'Neoplasms-involved-Neurodegenerative Diseases', 'NEUROD6-involved-Neoplasms', 'ID1-involved-Neoplasms', 'ID1-result-Neurodegenerative Diseases', 'TCF4-involved-Neoplasms', 'MYT1L-result-Neoplasms', 'MYT1L-involved-Neoplasms', 'MYT1L-result-Neurodegenerative Diseases', 'Neoplasms-find-PLK2', 'MIR184-include-Valproic Acid', 'MIR222-include-Valproic Acid', 'MIR429-chemosensitize-Neoplasms', 'MIR323A-include-Neoplasms', 'MIR328-include-Valproic Acid', 'MIR182-include-Neoplasms', 'MIR217-include-Neoplasms', 'MIR324-include-Neoplasms', 'ACE-consist-Digoxin', 'Glucose-use-Fructosamine', 'Glucose-use-Diabetes Mellitus', 'Diabetes Mellitus, Type 2-monitor-Fructosamine', 'Bleomycin-consist-Etoposide', 'Bleomycin-consist-Doxorubicin', 'Dyskinesias-decrease-Glucose', 'Lysosomal Storage Diseases-occur-Sugars', 'Diabetic Nephropathies-include-Cardiomegaly', 'Kidney Diseases-include-Cardiomegaly', 'ADCYAP1-shown-Cardiomegaly', 'ADCYAP1-shown-Diabetic Nephropathies', 'ADCYAP1-shown-Kidney Diseases', 'Streptozocin-include-Cardiomegaly', 'Diabetic Nephropathies-induced-Streptozocin', 'Gentamicins-include-Cardiomegaly', 'Fructosamine-considered-Glucose', 'Fructosamine-considered-Hematologic Diseases', 'Venous Thromboembolism-conducted-Heparin', 'Venous Thromboembolism-conducted-Heparin, Low-Molecular-Weight', 'Venous Thromboembolism-conducted-Fondaparinux', 'G(M1) Ganglioside-differ-N-Acetylneuraminic Acid', 'G(M1) Ganglioside-differ-Ceramides', 'Sulfoglycosphingolipids-accumulate-Ceramides', 'Epoprostenol-outperform-Heparin, Low-Molecular-Weight', 'Glucose-reduce-Gangliosides', 'Doxorubicin-prolong-Neoplasms', 'Etoposide-prolong-Neoplasms', 'Gangliosidoses-caused-G(M1) Ganglioside', 'Gangliosidoses-caused-G(M2) Ganglioside', 'Etoposide-pass-Neoplasm Metastasis', 'Glucose-normalize-Blood Glucose', 'INS-normalize-Blood Glucose', 'Teniposide-pass-Neoplasm Metastasis', 'Acarbose-act-Glucose', 'Mucopolysaccharidosis I-associated-Dermatan Sulfate', 'Dermatan Sulfate-associated-Mucopolysaccharidosis I', 'Anthracyclines-show-Doxorubicin', 'Anthracyclines-show-Neoplasms', 'Doxorubicin-show-Neoplasms', 'Glucose Metabolism Disorders-include-Diabetes Mellitus', 'Glycogen-include-Diabetes Mellitus', 'Heparitin Sulfate-cause-Hypertrophy', 'Glucose-included-Acarbose', 'Glucose-included-SLC5A2', 'Anemia, Sickle Cell-recommend-Diabetes Mellitus', 'Doxorubicin-conjugated-Chondroitin Sulfates', 'Doxorubicin-expressed-Melanoma', 'Chondroitin Sulfates-expressed-Melanoma', 'Heparin-compare-Neoplasms', 'Heparin, Low-Molecular-Weight-appear-Venous Thromboembolism', 'Enoxaparin-appear-Venous Thromboembolism', 'INS-increase-Glycerol', 'Dalteparin-appear-Venous Thromboembolism', 'Anemia, Sickle Cell-measure-Glucose', 'INS-increase-Fatty Acids', 'Diabetes Mellitus-measure-Glucose', 'Neoplasms-suppress-Autoimmune Diseases', 'Hexoses-enhance-Neoplasms', 'Hexoses-suppress-Autoimmune Diseases', 'Diabetes Mellitus-recommend-Fructosamine', 'Heparitin Sulfate-include-Glycosaminoglycans', 'Mucopolysaccharidoses-characterized-Glycosaminoglycans', 'Colorectal Neoplasms-decrease-Eicosapentaenoic Acid', 'Colorectal Neoplasms-decrease-Docosahexaenoic Acids', 'Epoprostenol-show-Pulmonary Arterial Hypertension', 'Iloprost-show-Pulmonary Arterial Hypertension', 'Metabolic Syndrome-diagnosed-Hypertension', 'Metabolic Syndrome-diagnosed-Glucose Intolerance', 'Metabolic Syndrome-diagnosed-Triglycerides', 'Fatty Acids, Omega-3-associated-Triglycerides', 'Triglycerides-associated-Fatty Acids, Omega-3', 'Fatty Acids, Omega-3-associated-Fatty Liver', 'Fatty Liver-associated-Fatty Acids, Omega-3', 'Fatty Acids-involved-Cholesterol', 'Fatty Acids-involved-Atherosclerosis', 'Glucose-revise-Sclerosis', 'Drug-Related Side Effects and Adverse Reactions-include-Diabetes Mellitus', 'Drug-Related Side Effects and Adverse Reactions-include-Cardiovascular Diseases', 'Drug-Related Side Effects and Adverse Reactions-cited-Cardiovascular Diseases', 'Drug-Related Side Effects and Adverse Reactions-include-INS', 'Drug-Related Side Effects and Adverse Reactions-include-Cholesterol', 'Eicosapentaenoic Acid-related-Death, Sudden, Cardiac', 'Eicosapentaenoic Acid-shown-Death, Sudden, Cardiac', 'Docosahexaenoic Acids-related-Death, Sudden, Cardiac', 'Docosahexaenoic Acids-shown-Death, Sudden, Cardiac', 'Drug-Related Side Effects and Adverse Reactions-include-Triglycerides', 'Linoleic Acid-associated-Coronary Artery Disease', 'Coronary Artery Disease-associated-Linoleic Acid', 'Trans Fatty Acids-associated-Coronary Artery Disease', 'Coronary Artery Disease-associated-Trans Fatty Acids', 'APOB-done-Cholesterol', 'APOB-done-Triglycerides', 'Phospholipids-cause-Ceramides', 'Fatty Acids-altered-Alzheimer Disease', 'Alzheimer Disease-display-Docosahexaenoic Acids', 'Alzheimer Disease-display-Oleic Acid', 'Cholesterol-associated-Cyclosporine', 'Cyclosporine-associated-Cholesterol', 'Triglycerides-associated-Cyclosporine', 'Cyclosporine-associated-Triglycerides', 'Gangliosides-lead-Dementia', 'Cholesterol-induced-Neurodegenerative Diseases', 'Diabetes Mellitus-associated-Cyclosporine', 'Cyclosporine-associated-Diabetes Mellitus', 'Cholesterol-lead-Dementia', 'Osteoporosis-investigate-Cholecalciferol', 'Osteoporosis-investigate-Calcitriol', 'AGPAT2-caused-Phosphatidic Acids', 'AGPAT2-caused-Glycerophospholipids', 'AGPAT2-caused-Triglycerides', 'Cholesterol-related-Infarction', 'Triglycerides-related-Stroke', 'Triglycerides-related-Infarction', 'Fatty Acids, Unsaturated-play-Atherosclerosis', 'Dyslipidemias-based-Cholesterol', 'Dyslipidemias-based-Triglycerides', 'Diabetes Mellitus, Type 2-show-Cholesterol', 'Drug-Related Side Effects and Adverse Reactions-increase-Cholesterol', 'Drug-Related Side Effects and Adverse Reactions-increase-Phospholipids', 'EDN1-involved-Renal Insufficiency', 'EDN1-culminate-Renal Insufficiency', 'Neoplasms-shown-Oleic Acids', 'Thromboxane A2-involved-Renal Insufficiency', 'Thromboxane A2-culminate-Renal Insufficiency', 'Neoplasms-shown-Palmitic Acid', 'Leukotrienes-involved-Renal Insufficiency', 'Leukotrienes-culminate-Renal Insufficiency', 'Metabolic Syndrome-measured-Glucose', 'Metabolic Syndrome-measured-Triglycerides', 'Metabolic Syndrome-measured-Cholesterol', 'Hypertension-used-Hyperlipidemias', 'Epoprostenol-restricted-Pulmonary Arterial Hypertension', 'Cholesterol-defined-Hypertension', 'Corn Oil-determined-Neoplasms', 'Fish Oils-determined-Neoplasms', 'TPCN2-associated-Cholesterol', 'Cholesterol-associated-TPCN2', 'TPCN2-associated-Lipofuscin', 'Lipofuscin-associated-TPCN2', 'Infliximab-associated-Cholesterol', 'Cholesterol-associated-Infliximab', 'Phospholipids-measure-Phosphatidylserines', 'Ceramides-play-Cystic Fibrosis', 'Sphingolipids-play-Cystic Fibrosis', 'Epoprostenol-confirm-Iloprost', 'Pulmonary Arterial Hypertension-confirm-Epoprostenol', 'Pulmonary Arterial Hypertension-confirm-Iloprost', 'Exenatide-compare-INS', 'Hypoglycemia-represent-INS', 'Exenatide-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-Exenatide', 'Hypoglycemia-projected-Insulin Detemir', 'Exenatide-associated-Death', 'Death-associated-Exenatide', 'Hypoglycemia-projected-Insulin, Isophane', 'Exenatide-fall-Insulin Glargine', 'Exenatide-fall-INS', 'Hypoglycemia-projected-Insulin Glargine', 'Insulin Detemir-associated-Insulin Glargine', 'Insulin Glargine-associated-Insulin Detemir', 'Insulin Detemir-associated-INS', 'INS-associated-Insulin Detemir', 'INS-associated-Insulin, Isophane', 'Insulin, Isophane-associated-INS', 'Exenatide-gained-Insulin Glargine', 'Exenatide-gained-INS', 'Exenatide-increase-Insulin Glargine', 'Exenatide-increase-INS', 'Cetuximab-administer-EGFR', 'Panitumumab-administer-EGFR', 'Colorectal Neoplasms-administer-EGFR', 'Bevacizumab-approved-Colorectal Neoplasms', 'Cetuximab-approved-Colorectal Neoplasms', 'rs7799039-associated-LEP', 'LEP-associated-rs7799039', 'rs2167270-associated-LEP', 'LEP-associated-rs2167270', 'LEP-explained-Obesity', 'rs7799039-associated-Obesity', 'Obesity-associated-rs7799039', 'rs7799039-explained-Obesity', 'rs2167270-associated-Obesity', 'Obesity-associated-rs2167270', 'rs2167270-explained-Obesity', 'rs1143627-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-rs1143627', 'rs1800562-express-Hemochromatosis', 'rs34637584-include-LRRK2', 'rs35801418-include-LRRK2', 'rs34778348-include-LRRK2', 'rs121913507-detected-H19', 'LRRK2-accompanied-Gait Disorders, Neurologic', 'rs34637584-accompanied-Gait Disorders, Neurologic', 'rs35801418-accompanied-Gait Disorders, Neurologic', 'rs34778348-accompanied-Gait Disorders, Neurologic', 'Non-alcoholic Fatty Liver Disease-encompass-CDKN2B-AS1', 'HFE-reveal-rs1800562', 'Non-alcoholic Fatty Liver Disease-encompass-rs1800795', 'Non-alcoholic Fatty Liver Disease-encompass-rs1556516', 'Cardiomyopathies-associate-MTCH2', 'MTCH2-associate-Cardiomyopathies', 'rs1064608-overrepresented-Cardiomyopathies', 'Cardiomyopathies-associate-rs10838738', 'rs10838738-associate-Cardiomyopathies', 'rs2253310-identify-FOXO3', 'rs2802292-identify-FOXO3', 'rs4946936-identify-FOXO3', 'HLCS-show-rs769499327', 'HLCS-show-rs119103229', 'FOXO3-find-rs2802292', 'FOXO3-find-rs2253310', 'TIAM1-show-Drug-Related Side Effects and Adverse Reactions', 'rs149744081-show-Drug-Related Side Effects and Adverse Reactions', 'rs1249016772-show-Drug-Related Side Effects and Adverse Reactions', 'TBP-validate-rs200487063', 'TBP-validate-rs201381696', 'TBP-validate-rs34104384', 'Hemophilia A-result-Coagulation Protein Disorders', 'Hemophilia A-result-Hemophilia B', 'Blood Coagulation Disorders, Inherited-characterized-Coagulation Protein Disorders', 'Blood Coagulation Disorders, Inherited-characterized-Hemophilia A', 'Blood Coagulation Disorders, Inherited-characterized-Hemophilia B', 'Blood Coagulation Disorders, Inherited-characterized-Hemorrhage', 'Blood Coagulation Disorders, Inherited-result-Hemorrhage', 'Coagulation Protein Disorders-result-Hemorrhage', 'Hemophilia B-result-Hemorrhage', 'Hemophilia A-result-F9', 'Blood Coagulation Disorders, Inherited-characterized-F9', 'F9-result-Hemorrhage', 'MAPK1-activated-Infections', 'Oculocerebrorenal Syndrome-characterised-Kidney Diseases', 'Oculocerebrorenal Syndrome-cause-OCRL', 'Hypothyroidism-associated-SHBG', 'SHBG-associated-Hypothyroidism', 'Genetic Diseases, Inborn-result-Dysplastic Nevus Syndrome', 'Dysplastic Nevus Syndrome-follow-Leukemia', 'Leukemia, Myeloid, Acute-follow-Leukemia', 'Dysplastic Nevus Syndrome-influence-SAMD9', 'Leukemia, Myeloid, Acute-influence-SAMD9', 'Infliximab-decreased-Hypertrophy', 'Infliximab-suggest-Heart Failure', 'Leukemia-influence-SAMD9', 'Breast Neoplasms, Male-include-Obesity', 'Heart Diseases-attenuate-Hypertrophy', 'Fibrosis-attenuate-Hypertrophy', 'Mitochondrial Diseases-include-Heart Diseases', 'PDE4B-attenuate-Hypertrophy', 'NPC1-disrupt-Cholesterol', 'Diabetes Mellitus-reduce-SLC5A2', 'SLC5A2-reduce-Death', 'Plaque, Atherosclerotic-reach-Cardiovascular Diseases', 'Genetic Diseases, Inborn-disrupt-Cholesterol', 'KL-act-Ovarian Neoplasms', 'Cholesterol-lead-Neurodegenerative Diseases', 'Fatty Acids, Omega-3-play-Obesity', 'Fatty Acids, Omega-3-associated-Atherosclerosis', 'Atherosclerosis-associated-Fatty Acids, Omega-3', 'Fatty Acids, Omega-3-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-Fatty Acids, Omega-3', 'Genetic Diseases, Inborn-result-Cystic Fibrosis', 'Bone Diseases-result-Cystic Fibrosis', 'Cystic Fibrosis-result-CFTR', 'Genetic Diseases, Inborn-result-CFTR', 'Bone Diseases-result-CFTR', 'rs10895068-include-Obesity', 'Insulin Resistance-play-INS', 'Diabetes Mellitus-play-INS', 'Wounds and Injuries-include-Diabetic Angiopathies', 'INS-include-Diabetic Angiopathies', 'Inflammation-represent-CDK9', 'Arthritis, Rheumatoid-represent-CDK9', 'SIRT2-ameliorate-Parkinson Disease', 'SIRT2-ameliorate-Neurodegenerative Diseases', 'AGER-implicated-Diabetic Angiopathies', 'Metabolic Syndrome-associate-Obesity, Abdominal', 'Obesity, Abdominal-associate-Metabolic Syndrome', 'Metabolic Syndrome-associate-Erectile Dysfunction', 'Erectile Dysfunction-associate-Metabolic Syndrome', 'AGER-play-Diabetic Angiopathies', 'Doxorubicin-exhibit-Drug-Related Side Effects and Adverse Reactions', 'AGER-play-Kidney Diseases', 'Doxorubicin-exhibit-Neoplasms', 'Ventricular Dysfunction-occur-Heart Failure', 'Ventricular Remodeling-occur-Heart Failure', 'Heart Failure-use-ACE', 'Prostatic Neoplasms-performed-KLK3', 'Hypercalcemia-indicate-Neoplasms', 'Death-performed-KLK3', 'PTHLH-indicate-Neoplasms', 'NTRK2-induce-Death', 'NTRK2-induce-Growth Disorders', 'APOB-reduce-Cardiovascular Diseases', 'APOB-reduce-Death', 'DDN-colocalize-Glomerulonephritis', 'DDN-colocalize-Kidney Diseases', 'Breast Neoplasms-overexpressed-Neoplasms', 'Death-exacerbated-Nerve Degeneration', 'XIAP-prevent-Death', 'Venous Thromboembolism-expand-Heparin, Low-Molecular-Weight', 'XIAP-exacerbated-Nerve Degeneration', 'Metabolic Diseases-described-Muscular Atrophy, Spinal', 'Glucose Intolerance-described-Muscular Atrophy, Spinal', 'Fatty Acids-described-Muscular Atrophy, Spinal', 'Niemann-Pick Disease, Type C-accumulated-Sphingolipids', 'Thyroid Hormone Resistance Syndrome-result-Thyroid Crisis', 'Sphingolipids-develop-Neurodegenerative Diseases', 'Hypothyroidism-result-Thyroid Crisis', 'Lipodystrophy-lead-Hypertriglyceridemia', 'Lipodystrophy-lead-Fatty Liver', 'Lipodystrophy-lead-INS', 'Glucose Metabolism Disorders-exploit-Prostatic Neoplasms', 'Glucose Metabolism Disorders-exploit-Hyperkinesis', 'Glucose Metabolism Disorders-display-Hyperkinesis', 'Prostatic Neoplasms-display-Hyperkinesis', 'LEP-associated-Aneurysm', 'Aneurysm-associated-LEP', 'AKT1-exploit-Glucose Metabolism Disorders', 'AKT1-display-Glucose Metabolism Disorders', 'AKT1-exploit-Prostatic Neoplasms', 'AKT1-display-Prostatic Neoplasms', 'AKT1-exploit-Hyperkinesis', 'LEP-associated-Lipodystrophy', 'Lipodystrophy-associated-LEP', 'Breast Neoplasms-predict-Neoplasm Metastasis', 'PTHLH-identify-Breast Neoplasms', 'PTHLH-identify-Neoplasm Metastasis', 'Drug-Related Side Effects and Adverse Reactions-implicated-Neurodegenerative Diseases', 'CLU-protect-Drug-Related Side Effects and Adverse Reactions', 'Nivolumab-approve-Hodgkin Disease', 'INS-play-Obesity', 'SCGB1A1-precede-Neurologic Manifestations', 'SCGB1A1-precede-Pulmonary Disease, Chronic Obstructive', 'Pseudomonas Infections-associated-Cystic Fibrosis', 'Cystic Fibrosis-associated-Pseudomonas Infections', 'Tobramycin-associated-Cystic Fibrosis', 'Cystic Fibrosis-associated-Tobramycin', 'NLRP1-expressed-Colorectal Neoplasms', 'NLRP1-associated-Neoplasms', 'Neoplasms-associated-NLRP1', 'NLRP1-associate-Neoplasms', 'Neoplasms-associate-NLRP1', 'Foot Ulcer-improve-Cilastatin, Imipenem Drug Combination', 'Cilastatin, Imipenem Drug Combination-improve-Diabetic Foot', 'Diabetes Mellitus-open-Ghrelin', 'Heart Arrest-operate-Neoplasms', 'Heart Arrest-operate-TP53', 'GH1-present-Adenoma', 'GH1-present-Pituitary Neoplasms', 'Neoplasms-detected-Carcinoma, Hepatocellular', 'Carcinoma, Hepatocellular-detected-Infections', 'TP53-detected-Carcinoma, Hepatocellular', 'Carcinoma, Hepatocellular-detected-Aflatoxin B1', 'Parkinson Disease-characterized-Mitochondrial Diseases', 'Cystic Fibrosis-begin-Steatorrhea', 'Cystic Fibrosis-begin-Weight Gain', 'Cystic Fibrosis-begin-Signs and Symptoms, Respiratory', 'Cystic Fibrosis-begin-Cough', 'Muscular Dystrophy, Duchenne-result-Muscle Weakness', 'Muscular Dystrophy, Duchenne-result-Cardiomyopathies', 'DMD-result-Muscle Weakness', 'DMD-result-Cardiomyopathies', 'LIF-facilitate-Inflammation', 'LIF-maintain-Neoplasms', 'LIF-maintain-Chordoma', 'Obesity-treat-Diabetes Mellitus', 'Obesity-treat-Diabetic Cardiomyopathies', 'Dyslipidemias-treat-Diabetes Mellitus', 'Dyslipidemias-treat-Diabetic Cardiomyopathies', 'Hypertension-treat-Diabetic Cardiomyopathies', 'AGER-investigated-Diabetes Mellitus', 'PTEN-found-Neoplasm Metastasis', 'PTEN-found-Neoplasms', 'AGER-investigated-Diabetic Cardiomyopathies', 'AGER-investigated-Heart Failure', 'PTEN-found-Brain Neoplasms', 'Neoplasm Metastasis-downregulated-Neoplasms', 'Glucose-link-Hyperglycemia', 'Glucose-link-Atherosclerosis', 'Glucose-link-Kidney Diseases', 'PTEN-downregulated-Neoplasm Metastasis', 'Glucose-link-Cardiomyopathies', 'PTEN-downregulated-Neoplasms', 'Glucose-confer-Cardiovascular Diseases', 'Renal Insufficiency, Chronic-defined-ALB', 'Mitochondrial Diseases-lead-Blindness', 'OPA1-lead-Optic Atrophy', 'OPA1-lead-Mitochondrial Diseases', 'OPA1-lead-Blindness', 'Melanoma-transduced-MLANA', 'Inflammatory Bowel Diseases-lead-Inflammation', 'Osteoporosis-increase-Muscular Dystrophy, Duchenne', 'HNF4A-associated-Inflammatory Bowel Diseases', 'Inflammatory Bowel Diseases-associated-HNF4A', 'HNF4A-lead-Inflammation', 'Genetic Diseases, Inborn-characterized-Lung Diseases', 'Mucopolysaccharidosis III-associated-Mucopolysaccharidosis II', 'Mucopolysaccharidosis II-associated-Mucopolysaccharidosis III', 'Mucopolysaccharidosis III-associated-IDS', 'IDS-associated-Mucopolysaccharidosis III', 'Mucopolysaccharidosis II-associated-IDS', 'IDS-associated-Mucopolysaccharidosis II', 'Thrombocytopenia-show-Death', 'Thrombocytopenia-show-CRP', 'Glucose Metabolism Disorders-characterized-Insulin Resistance', 'Glucose Metabolism Disorders-characterized-INS', 'HTT-display-Huntington Disease', 'Anthracyclines-associated-Breast Neoplasms', 'Breast Neoplasms-associated-Anthracyclines', 'Anthracyclines-associated-Lymphoma', 'Lymphoma-associated-Anthracyclines', 'MTMR2-reduce-Neoplasm Metastasis', 'MTMR2-reduce-Stomach Neoplasms', 'EGFR-detected-Neoplasms', 'EGFR-detected-Colonic Neoplasms', 'EGFR-detected-Lung Neoplasms', 'INPP5D-investigate-Neoplasms', 'INPP5D-investigate-Leukemia, Myeloid', 'INPP5D-act-Neoplasms', 'INPP5D-act-Leukemia, Myeloid, Acute', 'INPP5D-associated-Leukemia, Myeloid, Acute', 'Leukemia, Myeloid, Acute-associated-INPP5D', 'Neoplasm Metastasis-play-HGF', 'HGF-promote-Neoplasms', 'Neoplasm Metastasis-produce-HGF', 'Macrophage Activation Syndrome-develop-Inflammation', 'Non-alcoholic Fatty Liver Disease-considered-Metabolic Syndrome', 'Non-alcoholic Fatty Liver Disease-characterized-Chemical and Drug Induced Liver Injury', 'Non-alcoholic Fatty Liver Disease-considered-Chemical and Drug Induced Liver Injury', 'Non-alcoholic Fatty Liver Disease-characterized-Inflammation', 'Non-alcoholic Fatty Liver Disease-considered-Inflammation', 'Metabolic Syndrome-characterized-Triglycerides', 'Hemophilia A-render-F8', 'F8-expose-Death', 'Dystonia-show-ATM', 'SIRT1-serve-Radiation Injuries', 'SIRT1-advance-Carcinoma, Hepatocellular', 'Carcinoma, Hepatocellular-become-Hypoxia', 'SIRT1-become-Hypoxia', 'Prostatic Neoplasms-initiate-KLK3', 'Hypertension-exercise-Obesity', 'Neoplasms-initiate-KLK3', 'Neoplasms-metabolize-Hypotension', 'Neoplasms-metabolize-Glucose', 'Tobramycin-associated-Hemoptysis', 'Hemoptysis-associated-Tobramycin', 'Tobramycin-associated-Pneumothorax', 'Pneumothorax-associated-Tobramycin', 'Inflammation-underlie-Obesity', 'Inflammation-suppress-Death', 'Obesity-suppress-Death', 'Arthritis, Psoriatic-express-CEACAM1', 'INS-underlie-Obesity', 'INS-suppress-Death', 'Prostaglandins-implicated-Obesity', 'CEACAM1-express-Dermatitis', 'Prostaglandins-implicated-Colorectal Neoplasms', 'Obesity-underlie-Prostaglandins', 'Death-suppress-Prostaglandins', 'Lipoma-belong-Obesity', 'Marfan Syndrome-caused-FBN1', 'Genetic Diseases, Inborn-caused-FBN1', 'Obesity-link-Neoplasms', 'Gemfibrozil-reduce-Cardiovascular Diseases', 'Gemfibrozil-reduce-Stroke', 'Immunologic Deficiency Syndromes-indicate-Adrenal Insufficiency', 'Immunologic Deficiency Syndromes-indicate-EPO', 'Cystinosis-occur-Hypothyroidism', 'Cystinosis-diagnosed-Thyrotropin', 'Hypothyroidism-diagnosed-Thyrotropin', 'Lung Neoplasms-benefit-Drug-Related Side Effects and Adverse Reactions', 'NUAK2-lead-Neoplasms', 'Death-benefit-Drug-Related Side Effects and Adverse Reactions', 'Microcephaly-harbour-SARS1', 'NUAK2-lead-Prostatic Neoplasms', 'Ataxia-harbour-SARS1', 'EGFR-benefit-Drug-Related Side Effects and Adverse Reactions', 'MTOR-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-MTOR', 'MTOR-associated-Epilepsy', 'Epilepsy-associated-MTOR', 'Metabolic Diseases-use-Cholesterol', 'Cholesterol-use-Hypertension', 'Chiari-Frommel Syndrome-found-Lupus Erythematosus, Systemic', 'Chiari-Frommel Syndrome-confirm-PRL', 'Lupus Erythematosus, Systemic-confirm-PRL', 'Niemann-Pick Disease, Type A-caused-SMPD1', 'PRL-participate-Lupus Erythematosus, Systemic', 'Lysosomal Storage Diseases-caused-SMPD1', 'Osteolysis-associated-Neoplasms', 'Neoplasms-associated-Osteolysis', 'Genetic Diseases, Inborn-caused-SMPD1', 'PRL-participate-Lupus Nephritis', 'CTSL-implicated-Neoplasms', 'CTSL-implicated-Osteolysis', 'CTSL-contribute-Osteolysis', 'Neoplasms-related-Ovarian Diseases', 'Ovarian Diseases-advise-Neoplasms', 'AMH-assess-Ovarian Diseases', 'AMH-advise-Neoplasms', 'PGM1-indicate-Carcinoma, Hepatocellular', 'PGM1-indicate-Liver Failure', 'NODAL-reduce-Neoplasms', 'Alzheimer Disease-obtained-Dementia', 'Cholesterol-obtained-Dementia', 'Carcinoma, Pancreatic Ductal-identify-Neoplasms', 'Carcinoma, Pancreatic Ductal-measure-Neoplasms', 'Polycystic Ovary Syndrome-affect-Lipoma', 'Polycystic Ovary Syndrome-affect-INS', 'rs113488022-occur-Melanoma', 'rs113488022-occur-Glioma', 'Heart Diseases-portrayed-Cardiotoxicity', 'Trastuzumab-portrayed-Cardiotoxicity', 'Stomach Neoplasms-associated-Heart Neoplasms', 'Heart Neoplasms-associated-Stomach Neoplasms', 'Stomach Neoplasms-associated-Neoplasms', 'Neoplasms-associated-Stomach Neoplasms', 'Neoplasms-associated-Heart Neoplasms', 'Heart Neoplasms-associated-Neoplasms', 'SOX2-associated-Heart Neoplasms', 'Heart Neoplasms-associated-SOX2', 'SOX2-associated-Neoplasms', 'Neoplasms-associated-SOX2', 'EGFR-regulate-Cardiomegaly', 'EGFR-regulate-Fibrosis', 'SOX2-correlate-Heart Neoplasms', 'SOX2-correlate-Stomach Neoplasms', 'Acromegaly-associated-Hypogonadism', 'Hypogonadism-associated-Acromegaly', 'GH1-associated-Hypogonadism', 'Hypogonadism-associated-GH1', 'Brain Neoplasms-exhibit-Lymphoma, Non-Hodgkin', 'Brain Neoplasms-exhibit-Glioblastoma', 'Ganglioglioma-exhibit-Lymphoma, Non-Hodgkin', 'Coinfection-associated-Glucose Intolerance', 'Glucose Intolerance-associated-Coinfection', 'Neoplasms, Neuroepithelial-exhibit-Lymphoma, Non-Hodgkin', 'Brain Neoplasms-exhibit-BRAF', 'Ganglioglioma-exhibit-BRAF', 'Neoplasms, Neuroepithelial-exhibit-BRAF', 'Astrocytoma-exhibit-BRAF', 'Lymphoma, Non-Hodgkin-exhibit-BRAF', 'Glioblastoma-epitheloid-BRAF', 'Glioblastoma-exhibit-BRAF', 'GH1-include-Kidney Failure, Chronic', 'GH1-characterized-Kidney Failure, Chronic', 'GH1-include-Turner Syndrome', 'GH1-include-Growth Disorders', 'GH1-include-Fetal Growth Retardation', 'GH1-include-Noonan Syndrome', 'Mitochondrial Diseases-prevent-Diabetes Mellitus', 'Gaucher Disease-develop-Fanconi Syndrome', 'Gaucher Disease-develop-Fractures, Bone', 'Gaucher Disease-develop-Osteomyelitis', 'Hyperinsulinism-increase-Neoplasms', 'Breast Neoplasms-upregulated-Neoplasms', 'LDHB-upregulated-Breast Neoplasms', 'Weight Gain-include-INS', 'Hypoglycemia-include-INS', 'Bone Neoplasms-caused-Osteoporosis', 'PTH-reverse-Bone Neoplasms', 'PTH-caused-Osteoporosis', 'Obesity-induced-INS', 'Hyperandrogenism-aimed-INS', 'Neoplasm Metastasis-found-Colorectal Neoplasms', 'Death-receive-Atorvastatin', 'Calcitriol-hindered-Hypercalcemia', 'Coronary Artery Disease-receive-Atorvastatin', 'Myocardial Infarction-receive-Atorvastatin', 'Stroke-receive-Atorvastatin', 'Ischemia-receive-Atorvastatin', 'Hemorrhage-receive-Atorvastatin', 'Brain Diseases-marked-Heart Diseases', 'RREB1-derived-Teratocarcinoma', 'Rhabdomyolysis-marked-Heart Diseases', 'RREB1-derived-Kidney Diseases', 'Endometrial Stromal Tumors-cause-Tinnitus', 'TANGO2-involve-Brain Diseases', 'Endometrial Stromal Tumors-cause-Deafness', 'TANGO2-involve-Rhabdomyolysis', 'VHL-develop-Endometrial Stromal Tumors', 'TANGO2-marked-Heart Diseases', 'VHL-cause-Tinnitus', 'VHL-cause-Deafness', 'VHL-made-Hemangioblastoma', 'VHL-made-Pancreatic Cyst', 'Heart Diseases-cause-Rhabdomyolysis', 'Death-cause-Rhabdomyolysis', 'TANGO2-cause-Heart Diseases', 'TANGO2-cause-Death', 'TANGO2-cause-Rhabdomyolysis', 'Hypotension-enhance-Diabetes Mellitus', 'INS-enhance-Diabetes Mellitus', 'Hearing Loss-interfere-INS', 'Pain-interfere-INS', 'Diabetes Mellitus-shown-Heart Diseases', 'Diabetes Mellitus-ameliorate-Heart Diseases', 'Diabetes Mellitus-shown-Heart Failure', 'Diabetes Mellitus-indicate-Heart Failure', 'Heart Diseases-ameliorate-Heart Failure', 'SLC5A2-indicate-Diabetes Mellitus', 'SLC5A2-shown-Heart Diseases', 'SLC5A2-ameliorate-Heart Diseases', 'SLC5A2-shown-Heart Failure', 'NPC1-manage-Cholesterol', 'SLC5A2-indicate-Glucose', 'Niemann-Pick Disease, Type C-manage-Cholesterol', 'SLC5A2-demonstrate-Heart Failure', 'Genetic Diseases, Inborn-manage-Cholesterol', 'Drug Hypersensitivity-associated-Pulmonary Arterial Hypertension', 'Pulmonary Arterial Hypertension-associated-Drug Hypersensitivity', 'IL13-associated-Pulmonary Arterial Hypertension', 'Pulmonary Arterial Hypertension-associated-IL13', 'Diabetes Mellitus-result-Hypoglycemia', 'Ataxia Telangiectasia-caused-ATM', 'Shy-Drager Syndrome-caused-ATM', 'Mucopolysaccharidosis III-characterize-Neurodegenerative Diseases', 'Mucopolysaccharidosis III-characterize-Retinal Degeneration', 'Neurodegenerative Diseases-characterize-Retinal Degeneration', 'Infections-investigate-Neoplasms', 'Diabetes Mellitus-lower-Glucose', 'Topiramate-offer-Seizures', 'Glycogen Storage Disease Type II-caused-Glycogen', 'Genetic Diseases, Inborn-caused-Glycogen', 'Diabetes Mellitus-derived-Myalgia', 'SIRT1-derived-Diabetes Mellitus', 'Diabetes Mellitus-confused-Respiratory Tract Infections', 'Hyperparathyroidism-result-Adrenal Insufficiency', 'Acquired Immunodeficiency Syndrome-observed-Lipodystrophy', 'Acquired Immunodeficiency Syndrome-related-INS', 'Acquired Immunodeficiency Syndrome-observed-INS', 'Amyotrophic Lateral Sclerosis-underlie-Neuromuscular Diseases', 'WWOX-known-Neurodegenerative Diseases', 'Muscular Diseases-underlie-Neuromuscular Diseases', 'WWOX-known-Alzheimer Disease', 'MATR3-linked-Amyotrophic Lateral Sclerosis', 'MATR3-linked-Muscular Diseases', 'MATR3-underlie-Neuromuscular Diseases', 'Metabolic Syndrome-made-Diabetes Mellitus', 'Neoplasms-express-Stomach Neoplasms', 'Neoplasms-reduce-Stomach Neoplasms', 'Heart Arrest-downregulate-CCNB1', 'Hypertension-defined-Diabetes Mellitus, Type 2', 'CCNB1-induce-Death', 'Hypertension-defined-Obesity', 'Hypertension-defined-Glucose', 'Alzheimer Disease-model-Death', 'Alzheimer Disease-model-APOE', 'INS-maintain-Hypotension', 'Renal Insufficiency, Chronic-suffer-Anemia', 'Leber Congenital Amaurosis-associated-RPE65', 'RPE65-associated-Leber Congenital Amaurosis', 'Anemia-treated-EPO', 'Ventricular Dysfunction-improve-Heart Failure', 'GGH-improve-Ventricular Dysfunction', 'Atherosclerosis-exert-Obesity', 'Atherosclerosis-exert-Diabetes Mellitus', 'Atherosclerosis-exert-Fatty Liver', 'Atherosclerosis-known-Metabolic Syndrome', 'Fatty Acids-exert-INS', 'Atherosclerosis-exert-INS', 'Blood Coagulation Disorders-known-Metabolic Syndrome', 'Atherosclerosis-exert-Fatty Acids', 'Sialic Acid Storage Disease-represent-Heredodegenerative Disorders, Nervous System', 'Hypertension-known-Metabolic Syndrome', 'Fatty Acids-exert-Obesity', 'Sialic Acid Storage Disease-represent-Psychomotor Disorders', 'GNRH1-increase-Diabetes Mellitus', 'Sialic Acid Storage Disease-represent-Ataxia', 'GNRH1-increase-Cardiovascular Diseases', 'Neuroendocrine Tumors-occur-Sialic Acid Storage Disease', 'Fatty Acids-exert-Diabetes Mellitus', 'Sialic Acid Storage Disease-represent-Muscle Hypotonia', 'Sialic Acid Storage Disease-represent-Muscle Spasticity', 'N-Acetylneuraminic Acid-occur-Sialic Acid Storage Disease', 'VPS13B-characterized-Microcephaly', 'Heredodegenerative Disorders, Nervous System-occur-Psychomotor Disorders', 'VPS13B-cause-Muscle Hypotonia', 'Heredodegenerative Disorders, Nervous System-occur-Ataxia', 'Heredodegenerative Disorders, Nervous System-occur-Muscle Hypotonia', 'Obesity-involve-Mitochondrial Diseases', 'Heredodegenerative Disorders, Nervous System-occur-Muscle Spasticity', 'Sialic Acid Storage Disease-represent-N-Acetylneuraminic Acid', 'CFTR-lead-Fibrosis', 'Hypotension-evaluate-Diabetes Mellitus', 'Glucose-evaluate-Diabetes Mellitus', 'Polyendocrinopathies, Autoimmune-incorporate-Amyloidosis', 'Polyendocrinopathies, Autoimmune-incorporate-APOE', 'APOE-incorporate-Amyloidosis', 'Fabry Disease-cause-Glycosphingolipids', 'N-Acetylneuraminic Acid-base-Neoplasms', 'N-Acetylneuraminic Acid-treat-Neoplasms', 'N-Acetylneuraminic Acid-base-Infections', 'N-Acetylneuraminic Acid-treat-Infections', 'Genetic Diseases, X-Linked-cause-Glycosphingolipids', 'Glucose Intolerance-participate-Diabetes Mellitus', 'Glucose Intolerance-participate-Obesity', 'INS-participate-Diabetes Mellitus', 'INS-participate-Obesity', 'Diabetes Mellitus-emerge-Polycystic Ovary Syndrome', 'Diabetes Mellitus-emerge-Hyperandrogenism', 'Diabetes Mellitus-underpinned-INS', 'Polycystic Ovary Syndrome-underpinned-INS', 'Death-correlate-Sepsis', 'Death-correlate-ALB', 'Hemophilia A-caused-F8', 'Genetic Diseases, Inborn-caused-F8', 'Neurodegenerative Diseases-termed-Tauopathies', 'MAPT-termed-Tauopathies', 'Breast Neoplasms-considered-Cardiotoxicity', 'Breast Neoplasms-considered-Trastuzumab', 'Trastuzumab-associated-Cardiotoxicity', 'Cardiotoxicity-associated-Trastuzumab', 'Trastuzumab-considered-Cardiotoxicity', 'E4F1-result-Mitochondrial Diseases', 'E4F1-result-Death', 'Neoplasms-characterised-Neurilemmoma', 'E4F1-induce-Mitochondrial Diseases', 'Neoplasms-characterised-Meningeal Neoplasms', 'E4F1-induce-Death', 'E4F1-induce-Leukemia, Myeloid', 'Peutz-Jeghers Syndrome-caused-STK11', 'NF2-characterised-Neurilemmoma', 'NF2-characterised-Meningeal Neoplasms', 'Genetic Diseases, Inborn-caused-STK11', 'Cystic Fibrosis-vary-Mastocytosis, Systemic', 'Cystic Fibrosis-vary-Malnutrition', 'Cystic Fibrosis-vary-CFTR', 'Hearing Loss-show-Aneurysm', 'Fever-show-Aneurysm', 'Hearing Loss-show-Glycogen', 'Fever-show-Glycogen', 'Aneurysm-show-Glycogen', 'rs121908033-cause-Hypertrophy', 'rs121908033-cause-Fibrosis', 'Diabetes Mellitus-use-Pancreatitis', 'Diabetes Mellitus-result-Hyperglycemia', 'Metabolic Diseases-use-Pancreatitis', 'Diabetes Mellitus-present-HBA1', 'Metabolic Diseases-result-Hyperglycemia', 'Pancreatitis-result-Hyperglycemia', 'Metabolic Diseases-use-INS', 'INS-result-Hyperglycemia', 'CST3-proposed-Acute Kidney Injury', 'CST3-proposed-Chronic Kidney Disease-Mineral and Bone Disorder', 'Medulloblastoma-divided-SHH', 'Brain Neoplasms-divided-SHH', 'Venous Thromboembolism-complicated-Hemarthrosis', 'Venous Thromboembolism-complicated-INS', 'Carcinogenesis-play-MUC4', 'Carcinoma, Pancreatic Ductal-play-MUC4', 'Carcinoma, Pancreatic Ductal-enhance-MUC4', 'Jaundice, Obstructive-enhance-MUC4', 'Cystic Fibrosis-targeted-Inflammation', 'MUC4-decrease-Alveolar Bone Loss', 'Inflammation-targeted-CFTR', 'MUC4-decrease-Carcinoma, Pancreatic Ductal', 'Hemophilia A-caused-COX8A', 'Hemorrhage-caused-COX8A', 'GGH-involved-Neoplasms', 'GGH-associated-Breast Neoplasms', 'Breast Neoplasms-associated-GGH', 'Ipilimumab-treat-Melanoma', 'Dwarfism, Pituitary-shown-Neoplasms', 'GGH-shown-Neoplasms', 'SSX2-identify-Prostatic Neoplasms', 'SSX2-expressed-Prostatic Neoplasms', 'SSX2-find-Neoplasms', 'Alzheimer Disease-increase-Diabetes Mellitus', 'Nervous System Diseases-result-GALC', 'Alzheimer Disease-suggest-Metabolic Diseases', 'Alzheimer Disease-understood-Neurodegenerative Diseases', 'Prostatic Neoplasms-restricted-Neoplasms', 'Diabetes Mellitus-understood-Metabolic Diseases', 'SSX2-restricted-Neoplasms', 'Diabetes Mellitus-understood-Neurodegenerative Diseases', 'Prostatic Neoplasms-involved-Neoplasms', 'SSX2-involved-Neoplasms', 'TAT-carry-Doxorubicin', 'INS-suggest-Metabolic Diseases', 'TAT-lead-Drug-Related Side Effects and Adverse Reactions', 'INS-understood-Neurodegenerative Diseases', 'TAT-lead-Breast Neoplasms', 'Doxorubicin-lead-Drug-Related Side Effects and Adverse Reactions', 'Doxorubicin-lead-Breast Neoplasms', 'ERBB2-drive-Trastuzumab', 'ERBB2-drive-Breast Neoplasms', 'Trastuzumab-drive-Breast Neoplasms', 'Trastuzumab-drive-Neoplasms', 'Glucose-reduce-Diabetes Mellitus', 'Glucose-reduce-Death', 'Kidney Diseases-reflect-Inflammation', 'HIV Infections-reflect-Inflammation', 'CST3-proposed-Kidney Diseases', 'CST3-proposed-HIV Infections', 'CST3-reflect-Inflammation', 'Dwarfism, Pituitary-resemble-IGF1', 'Pituitary Diseases-resemble-IGF1', 'Fanconi Syndrome-associated-Proteinuria', 'Proteinuria-associated-Fanconi Syndrome', 'Proteinuria-studied-LCN2', 'LCN2-studied-Fanconi Syndrome', 'Fragile X Syndrome-rival-Intellectual Disability', 'Fragile X Syndrome-rival-Epilepsy', 'ARX-found-Abnormalities, Drug-Induced', 'ARX-rival-Fragile X Syndrome', 'ARX-found-Seizures', 'STAT5B-exhibit-Growth Disorders', 'FBXW7-considered-Neoplasms', 'FBXW7-considered-Carcinosarcoma', 'Genetic Diseases, Inborn-caused-CFTR', 'Pulmonary Arterial Hypertension-increased-Smooth Muscle Tumor', 'TNFRSF11B-increased-Pulmonary Arterial Hypertension', 'TNFRSF11B-increased-Smooth Muscle Tumor', 'APOB-cause-Heart Diseases', 'APOB-cause-Stroke', 'TNFRSF11B-associated-Vascular Remodeling', 'Vascular Remodeling-associated-TNFRSF11B', 'Heart Arrest-suppress-Breast Neoplasms', 'SLC6A6-result-Heart Arrest', 'SLC6A6-induce-Heart Arrest', 'SLC6A6-suppress-Breast Neoplasms', 'SLC6A6-affect-Neoplasms', 'SLC6A6-overexpressed-Neoplasms', 'SLC6A6-overexpressed-Leukemia', 'Drug-Related Side Effects and Adverse Reactions-produced-COMMD1', 'CBX7-upregulated-Lymphoma', 'Neoplasms-identified-Glioblastoma', 'Glioblastoma-express-PROM1', 'Neoplasms-express-PROM1', 'Heredodegenerative Disorders, Nervous System-characterized-Neurologic Manifestations', 'Heredodegenerative Disorders, Nervous System-characterized-Paralysis', 'Heredodegenerative Disorders, Nervous System-characterized-Neurodegenerative Diseases', 'SOD1-develop-Heredodegenerative Disorders, Nervous System', 'SOD1-characterized-Neurologic Manifestations', 'SOD1-characterized-Paralysis', 'Heart Failure-shown-Death', 'SOD1-characterized-Neurodegenerative Diseases', 'Hepatitis C-increase-Chemical and Drug Induced Liver Injury', 'Hepatitis C-blunt-CD4', 'CD4-increase-Chemical and Drug Induced Liver Injury', 'Cardiovascular Diseases-suppress-Acromegaly', 'Cardiovascular Diseases-suppress-Dwarfism, Pituitary', 'Cystic Fibrosis-predicated-Respiratory Tract Infections', 'Cystic Fibrosis-predicated-Exocrine Pancreatic Insufficiency', 'Cystic Fibrosis-predicated-CFTR', 'CFTR-lead-Respiratory Insufficiency', 'ADIPOQ-correlated-Weight Loss', 'ADIPOQ-correlated-Muscle Weakness', 'Carcinogenesis-exposed-Death', 'Carcinogenesis-combine-Aflatoxin B1', 'Death-combine-Aflatoxin B1', 'Hypoxia-increase-Phosphatidylserines', 'Bone Diseases, Metabolic-characterized-Seizures', 'ALPL-characterized-Seizures', 'Huntington Disease-reduce-Movement Disorders', 'Huntington Disease-rescue-Neurodegenerative Diseases', 'Movement Disorders-rescue-Neurodegenerative Diseases', 'Intellectual Disability-reduce-Renal Insufficiency', 'Anemia-palliated-EPO', 'Asthenia-palliated-EPO', 'Glucose-reduce-Movement Disorders', 'Infections-palliated-EPO', 'Glucose-rescue-Neurodegenerative Diseases', 'Diabetic Foot-present-Obesity', 'Diabetic Foot-present-Dyslipidemias', 'Diabetic Foot-present-Hypertension', 'Diabetic Foot-present-INS', 'Parkinson Disease-attenuate-Nerve Degeneration', 'rs121913514-induce-Myeloproliferative Disorders', 'rs121913514-induce-Leukemia, Lymphoid', 'IDS-implicated-Immunologic Deficiency Syndromes', 'Diabetes Mellitus-cause-Fractures, Bone', 'Glucose Metabolism Disorders-impact-Huntington Disease', 'INS-cause-Fractures, Bone', 'Neoplasms-treated-INS', 'Neoplasms-treated-Insulin Glargine', 'Diabetes Mellitus-treated-Insulin Glargine', 'Neoplasms-focus-Bone Marrow Diseases', 'CXCR4-applied-Neoplasms', 'CXCR4-applied-Bone Marrow Diseases', 'CXCR4-targeted-Bone Marrow Diseases', 'CXCR4-expressed-Breast Neoplasms', 'CXCR4-expressed-Prostatic Neoplasms', 'CXCR4-expressed-Pancreatic Neoplasms', 'CXCR4-expressed-Stomach Neoplasms', 'Bone Diseases-treat-Cystic Fibrosis', 'Teriparatide-treat-Cystic Fibrosis', 'Diabetes Mellitus-compare-Pyelonephritis', 'Diabetes Mellitus-compare-Glomerulonephritis', 'Drug-Related Side Effects and Adverse Reactions-include-Thrombocytosis', 'GH1-reduce-Fractures, Bone', 'Xanthomatosis-apply-Cholesterol', 'Cholesterol-apply-Coronary Artery Disease', 'Drug Hypersensitivity-compromise-Death', 'Death-prevent-Eosinophilia', 'MYOM2-lead-Cardiomyopathy, Hypertrophic', 'MYOM2-lead-Cardiovascular Diseases', 'MYOM2-result-Hypotension', 'MYOM2-result-Arrhythmias, Cardiac', 'SOX2-expressed-Neoplasms', 'SOX2-expressed-Glioblastoma', 'SOX2-expressed-Neuroblastoma', 'PCNT-cause-Growth Disorders', 'PCNT-cause-Microcephaly', 'INS-predicted-Glucose', 'INS-provide-Hyperglycemia', 'Hyperglycemia-predicted-Glucose', 'Hypoglycemia-predicted-Glucose', 'Spastic Paraplegia, Hereditary-shown-Amyotrophic Lateral Sclerosis', 'Spastic Paraplegia, Hereditary-shown-Motor Neuron Disease', 'Diabetes Mellitus-suggest-Hyperglycemia', 'ERLIN1-shown-Spastic Paraplegia, Hereditary', 'Diabetes Mellitus-augment-GLP1R', 'GLP1R-augment-Hyperglycemia', 'Inflammation-mediate-Obesity', 'Tauopathies-exacerbate-Anophthalmos', 'Lipoma-mediate-Obesity', 'Tauopathies-increase-MAPT', 'Genetic Diseases, Inborn-result-INSR', 'Genetic Diseases, Inborn-describe-INSR', 'Inflammation-mediate-INS', 'MAPT-exacerbate-Anophthalmos', 'INSR-associated-Hyperglycemia', 'Hyperglycemia-associated-INSR', 'INSR-associated-Hyperinsulinism', 'Hyperinsulinism-associated-INSR', 'Lipoma-mediate-INS', 'Drug-Related Side Effects and Adverse Reactions-cause-Peliosis Hepatis', 'Glutathione-cause-Peliosis Hepatis', 'Chronic Kidney Disease-Mineral and Bone Disorder-associated-Fractures, Bone', 'Fractures, Bone-associated-Chronic Kidney Disease-Mineral and Bone Disorder', 'PTH-persist-Chronic Kidney Disease-Mineral and Bone Disorder', 'Ulcer-include-Hyperkinesis', 'Digitalis Glycosides-reduce-Death', 'STING1-cause-Renal Insufficiency, Chronic', 'STING1-cause-Diabetic Nephropathies', 'Huntington Disease-ameliorate-Neurodegenerative Diseases', 'Infliximab-noted-Parkinson Disease', 'SIRT3-ameliorate-Neurodegenerative Diseases', 'Neoplasms-decline-AMH', 'Breast Neoplasms-decline-AMH', 'Thyroid Carcinoma, Anaplastic-overexpressed-Thyroid Neoplasms', 'ASH1L-overexpressed-Thyroid Carcinoma, Anaplastic', 'ASH1L-overexpressed-Thyroid Neoplasms', 'Leukodystrophy, Globoid Cell-induce-Demyelinating Diseases', 'Leukodystrophy, Globoid Cell-induce-Neurodegenerative Diseases', 'Leukodystrophy, Globoid Cell-caused-Psychosine', 'Demyelinating Diseases-induce-Psychosine', 'Neurodegenerative Diseases-induce-Psychosine', 'RFWD3-connected-Genetic Diseases, Inborn', 'ASH1L-involved-Neoplasms', 'RFWD3-connected-Fanconi Anemia', 'Embryo Loss-resemble-Fanconi Anemia', 'Epilepsy-cause-Optic Atrophy', 'Neuroaxonal Dystrophies-include-Neurodegenerative Diseases', 'CACNA1A-cause-Epilepsy', 'CACNA1A-cause-Optic Atrophy', 'Menkes Kinky Hair Syndrome-caused-ATP7A', 'Genetic Diseases, X-Linked-caused-ATP7A', 'SOST-depend-Osteoporosis', 'HIV Infections-experience-Opportunistic Infections', 'Neoplasms-check-Dyspnea', 'Neoplasms-check-Anorexia', 'Neoplasms-check-Hypotension', 'Neoplasms-check-Cholesterol', 'Topiramate-promote-Weight Loss', 'Dyslipidemias-found-Cholesterol', 'Hypercholesterolemia-found-Cholesterol', 'Diabetes Mellitus-lowering-Cholesterol', 'Hypotension-lowering-Cholesterol', 'EPO-counteract-Anemia', 'EPO-used-Renal Insufficiency', 'Kidney Failure, Chronic-evaluate-Kidney Diseases', 'Kidney Failure, Chronic-evaluate-CD79A', 'DBH-obtained-Dementia, Vascular', 'Sialic Acid Storage Disease-found-N-Acetylneuraminic Acid', 'Lysosomal Storage Diseases-found-N-Acetylneuraminic Acid', 'TBX3-enhanced-Gastritis, Atrophic', 'TBX3-observed-Stomach Neoplasms', 'TBX3-enhanced-Stomach Neoplasms', 'TBX3-involved-Carcinogenesis', 'Drug-Related Side Effects and Adverse Reactions-enable-Central Nervous System Diseases', 'Central Nervous System Diseases-contribute-Neurodegenerative Diseases', 'MAPT-enable-Central Nervous System Diseases', 'MAPT-facilitate-Neurodegenerative Diseases', 'Hereditary Breast and Ovarian Cancer Syndrome-characterized-Macular Degeneration', 'FOXN1-lead-Immunologic Deficiency Syndromes', 'FOXN1-lead-Hereditary Breast and Ovarian Cancer Syndrome', 'FOXN1-lead-Lymphoma, T-Cell', 'FOXN1-lead-Macular Degeneration', 'Pain-remain-CD4', 'PRTN3-receive-Granulomatosis with Polyangiitis', 'PRTN3-receive-Churg-Strauss Syndrome', 'STAT5A-gain-Leukemia, Myeloid', 'COA7-show-Anophthalmos', 'COA7-show-Gait Disorders, Neurologic', 'SIRT6-regulate-Inflammation', 'SIRT6-regulate-Diabetes Mellitus', 'Hypertension-recorded-Hyperglycemia', 'SIRT6-regulate-Obesity', 'Death-characterized-Phosphatidylserines', 'SIRT6-regulate-Neoplasms', 'Phosphatidylserines-cause-Anemia', 'Hyperglycemia-recorded-Glucose', 'Diabetes Mellitus-improve-Cystic Fibrosis', 'Kidney Diseases-receive-Kidney Failure, Chronic', 'Dyslipidemias-receive-Kidney Failure, Chronic', 'Kidney Failure, Chronic-reach-Cholesterol', 'INS-improve-Cystic Fibrosis', 'Inflammation-associated-Psoriasis', 'Psoriasis-associated-Inflammation', 'Psoriasis-enhance-Atherosclerosis', 'Inflammation-enhance-INS', 'Psoriasis-enhance-INS', 'Craniofacial Abnormalities-found-TGFBR2', 'Thrombosis-noted-JAK2', 'Essential Tremor-noted-JAK2', 'Polycythemia Vera-noted-JAK2', 'Topiramate-control-Weight Loss', 'BUB1-associated-Aneuploidy', 'Aneuploidy-associated-BUB1', 'Colorectal Neoplasms-demonstrated-Adrenal Insufficiency', 'BUB1-trigger-Aneuploidy', 'BUB1-associated-Neoplasms', 'Neoplasms-associated-BUB1', 'BUB1-trigger-Neoplasms', 'CEACAM3-demonstrated-Adrenal Insufficiency', 'Triglycerides-tried-Acquired Immunodeficiency Syndrome', 'Cholesterol-predispose-Death', 'Triglycerides-tried-Diarrhea', 'Cholesterol-predispose-Coronary Artery Disease', 'Cholesterol-predispose-Neoplasms', 'Ventricular Dysfunction-retarded-Heart Failure', 'Ventricular Dysfunction-retarded-AP2B1', 'Heart Failure-retarded-AP2B1', 'AXL-considered-Neoplasms', 'AXL-considered-Breast Neoplasms', 'AXL-played-Breast Neoplasms', 'AXL-played-Neoplasms', 'Neoplasms-act-Intestinal Diseases', 'Neoplasms-act-Colorectal Neoplasms', 'USP28-promote-Neoplasms', 'USP28-act-Intestinal Diseases', 'USP28-act-Colorectal Neoplasms', 'Neoplasms-act-USP28', 'Muscular Diseases-characterized-Muscle Rigidity', 'Muscular Diseases-characterized-Respiratory Insufficiency', 'Respiration Disorders-observed-SELENON', 'SELENON-characterized-Muscle Weakness', 'SELENON-characterized-Muscle Rigidity', 'SELENON-characterized-Respiratory Insufficiency', 'SELENON-encode-Muscle Weakness', 'SELENON-encode-Muscle Rigidity', 'SELENON-encode-Respiratory Insufficiency', 'Prostatitis-diagnosed-Prostatic Intraepithelial Neoplasia', 'Obesity-linked-Ovarian Diseases', 'Obesity-linked-Polycystic Ovary Syndrome', 'Ovarian Diseases-linked-Polycystic Ovary Syndrome', 'INS-linked-Ovarian Diseases', 'INS-linked-Polycystic Ovary Syndrome', 'Weight Loss-indicated-Neoplasms', 'Fatty Acids, Omega-3-indicated-Neoplasms', 'Glioma-increase-Neoplasms', 'Octreotide-reduce-Nausea', 'Neoplasms-increase-Glioblastoma', 'TNFRSF12A-induced-Glioma', 'Octreotide-reduce-Vomiting', 'Scleroderma, Localized-cured-Neoplasms', 'TNFRSF12A-increase-Neoplasms', 'Scleroderma, Localized-cured-KLK3', 'TNFRSF12A-induced-Glioblastoma', 'Hypertension-consist-Cholesterol', 'Bone Neoplasms-include-Hemorrhage', 'Bone Neoplasms-include-Malnutrition', 'Bone Neoplasms-include-Immunologic Deficiency Syndromes', 'Bone Neoplasms-include-F8', 'Genetic Diseases, X-Linked-caused-Coagulation Protein Disorders', 'SERPINA1-increase-Exocrine Pancreatic Insufficiency', 'SERPINA1-increase-Diabetes Mellitus', 'Seizures-compare-Obesity', 'Seizures-preserve-Obesity', 'INS-preserve-Obesity', 'Polycystic Ovary Syndrome-exhibit-Glucose', 'Glucose-exacerbated-Hirsutism', 'Metabolic Diseases-arise-ATP7B', 'Polycystic Ovary Syndrome-exhibit-Glucose Metabolism Disorders', 'Polycystic Ovary Syndrome-exhibit-Acanthosis Nigricans', 'Polycystic Ovary Syndrome-exhibit-Cholesterol', 'Huntington Disease-correlate-Nerve Degeneration', 'BCL2L11-increased-Huntington Disease', 'INSL3-increased-Polycystic Ovary Syndrome', 'INSL3-decrease-Primary Ovarian Insufficiency', 'BCL2L11-correlate-Nerve Degeneration', 'Tauopathies-represent-Neurodegenerative Diseases', 'Lysosomal Storage Diseases-caused-Heparitin Sulfate', 'Tauopathies-represent-MAPT', 'Hemophilia A-brought-Immunologic Deficiency Syndromes', 'Blood Coagulation Disorders, Inherited-brought-Immunologic Deficiency Syndromes', 'Lysosomal Storage Diseases-characterized-Cholesterol', 'Genetic Diseases, Inborn-characterized-Cholesterol', 'PLP1-result-Demyelinating Diseases', 'PLP1-result-Inflammation', "TNFRSF18-play-Sjogren's Syndrome", 'KLF8-transform-Ovarian Diseases', 'Melanoma-induce-Neoplasms', 'Blood Coagulation Disorders-related-HIV Infections', 'Blood Coagulation Disorders-express-HIV Infections', 'Melanoma-used-Doxorubicin', 'Melanoma-confirm-Doxorubicin', 'Blood Coagulation Disorders-related-F3', 'Blood Coagulation Disorders-express-F3', 'ESR1-modulate-Autoimmune Diseases', 'ESR1-modulate-Infections', 'ESR1-modulate-Wounds and Injuries', 'Dyslipidemias-lead-Diabetes Mellitus', 'Death-reduced-Fluvastatin', 'Fluvastatin-reduce-Death', 'Fluvastatin-reduce-Myocardial Infarction', 'Thyroid Neoplasms-associated-TG', 'TG-associated-Thyroid Neoplasms', 'Neoplasm Metastasis-removed-TG', 'Heart Arrest-induce-rs113488022', 'Heart Arrest-induced-IVNS1ABP', 'CARMN-compare-Ventricular Remodeling', 'CARMN-compare-Heart Failure', 'Neoplasms-identify-EREG', 'Genetic Diseases, Inborn-caused-Gaucher Disease', 'Acromegaly-ascribed-Pituitary Neoplasms', 'Acromegaly-described-GH1', 'GH1-ascribed-Pituitary Neoplasms', 'Hypoglycemia-promote-Inflammation', 'ACOX1-lead-Death', 'ACOX1-lead-Alcoholic Neuropathy', 'LMNA-result-Death', 'LMNA-result-Cardiovascular Diseases', 'Stroke-demonstrate-Hypertension', 'Enalapril-associated-Stroke', 'Stroke-associated-Enalapril', 'Stroke-demonstrate-Enalapril', 'Hypertension-treated-Enalapril', 'Cholesterol-display-Inflammatory Bowel Diseases', 'Cholesterol-display-Psoriasis', 'Meningeal Neoplasms-associated-NF2', 'NF2-associated-Meningeal Neoplasms', 'Death-associated-NF2', 'NF2-associated-Death', 'Heparin-see-Neoplasms', 'Nerve Degeneration-include-Mitochondrial Diseases', 'Atrophy-include-Mitochondrial Diseases', 'Polycystic Ovary Syndrome-include-Pathological Conditions, Anatomical', 'Granulosa Cell Tumor-include-Pathological Conditions, Anatomical', 'Primary Ovarian Insufficiency-include-Pathological Conditions, Anatomical', 'Stroke-induced-Heparin', 'Hemorrhage-induced-Heparin', 'Neoplasms-listed-Death', 'Death-show-NF1', 'NF1-listed-Death', 'Aneurysm-expect-Death', 'Aneurysm-recorded-NF1', 'Acquired Immunodeficiency Syndrome-increasing-Opportunistic Infections', 'Prader-Willi Syndrome-associated-Inflammation', 'Inflammation-associated-Prader-Willi Syndrome', 'FCGR3A-associated-Inflammation', 'Inflammation-associated-FCGR3A', 'GAST-increase-Gastrinoma', 'Diabetic Ketoacidosis-remain-Death', 'Prolactinoma-harbor-Neoplasms', 'Prolactinoma-harbor-PRL', 'INS-alter-Hypertrophy', 'INS-alter-Fibrosis', 'Drug-Related Side Effects and Adverse Reactions-do-Encephalitis', 'Idiopathic Pulmonary Fibrosis-occur-Fibrosis', 'Drug-Related Side Effects and Adverse Reactions-do-Acute Kidney Injury', 'Death-do-Chemical and Drug Induced Liver Injury', 'Idiopathic Pulmonary Fibrosis-visualise-Ascorbic Acid', 'Fibrosis-occur-Ascorbic Acid', 'Death-do-Encephalitis', 'Death-do-Acute Kidney Injury', 'STAG2-inactivated-Neoplasms', 'STAG2-associated-Aneuploidy', 'Aneuploidy-associated-STAG2', 'Drug-Related Side Effects and Adverse Reactions-lead-Nivolumab', 'Nivolumab-do-Chemical and Drug Induced Liver Injury', 'Nivolumab-do-Encephalitis', 'Nivolumab-do-Acute Kidney Injury', 'Oculocerebrorenal Syndrome-assessed-Neoplasms', 'CD164-characterize-Neoplasms', 'CD164-isolated-Neoplasms', 'Metabolic Diseases-associated-Chronic Disease', 'Chronic Disease-associated-Metabolic Diseases', 'CD164-characterize-Oculocerebrorenal Syndrome', 'CD164-isolated-Oculocerebrorenal Syndrome', 'Metabolic Diseases-promote-Diabetes Mellitus, Type 2', 'CD164-assessed-Neoplasms', 'CD164-associate-Neoplasms', 'Neoplasms-associate-CD164', 'Metabolic Diseases-promote-Hypertension', 'Brain Neoplasms-suggest-Glioma', 'Neoplasms-suggest-Glioma', 'FABP3-expressed-Brain Neoplasms', 'FABP3-expressed-Neoplasms', 'FABP3-suggest-Glioma', 'Muscular Dystrophy, Duchenne-support-Ventricular Dysfunction', 'Muscular Dystrophy, Duchenne-support-ACE', 'Non-alcoholic Fatty Liver Disease-include-Chronic Disease', 'Heart Diseases-given-Cardiotoxicity', 'Heart Diseases-lead-Cardiotoxicity', 'Obesity-comprise-Diabetes Mellitus', 'Heart Diseases-given-Trastuzumab', 'Trastuzumab-lead-Cardiotoxicity', 'Glucose Intolerance-comprise-Diabetes Mellitus', 'Hyperinsulinism-comprise-Diabetes Mellitus', 'INS-comprise-Diabetes Mellitus', 'INS-promote-Metabolic Diseases', 'INS-associated-Chronic Disease', 'Chronic Disease-associated-INS', 'VCP-result-Brain Injuries, Traumatic', 'VCP-slow-Alzheimer Disease', 'Kidney Failure, Chronic-studied-Death', 'Ketosis-include-Acidosis, Lactic', 'Ketosis-include-Sugars', 'CEACAM3-exhibit-Neoplasm Metastasis', 'CEACAM3-exhibit-Bankart Lesions', 'Thalassemia-found-Ascorbic Acid', 'Death-associated-CDKN2A', 'CDKN2A-associated-Death', 'Muscle Hypotonia-harbor-GEMIN5', 'Cerebellar Ataxia-harbor-GEMIN5', 'Muscular Dystrophy, Duchenne-lead-Muscle Weakness', 'Muscular Dystrophy, Duchenne-lead-Cardiomyopathy, Dilated', 'DMD-lead-Muscle Weakness', 'DMD-lead-Cardiomyopathy, Dilated', 'Genetic Diseases, Inborn-characterized-Cystic Fibrosis', 'Cystic Fibrosis-characterized-CFTR', 'Genetic Diseases, Inborn-characterized-CFTR', 'INS-fall-Glucose', 'Hyperglycemia-suspend-INS', 'Hypoglycemia-suspend-INS', 'Hyperglycemia-fall-Glucose', 'Hypoglycemia-fall-Glucose', 'Glucose-reduced-INS', 'Hyperandrogenism-reduced-INS', 'Polycystic Ovary Syndrome-reduced-INS', 'AKT1-myristoylate-Infections', 'AKT1-result-Infections', 'Malaria, Falciparum-myristoylate-AKT1', 'Glioma-reduce-Drug-Related Side Effects and Adverse Reactions', 'TNFSF10-induced-Drug-Related Side Effects and Adverse Reactions', 'TNFSF10-reduce-Drug-Related Side Effects and Adverse Reactions', 'Psoriasis-play-Cardiovascular Diseases', 'Psoriasis-associated-CRP', 'CRP-associated-Psoriasis', 'Neoplasms-bear-Carcinoma, Ehrlich Tumor', 'Glutathione-bear-Carcinoma, Ehrlich Tumor', 'Death-provide-Glioma', 'Muscle Weakness-develop-Respiratory Insufficiency', 'TNFRSF10B-provide-Glioma', 'OPA3-lead-Optic Atrophies, Hereditary', 'OPA3-lead-Cataract', 'GDAP1-develop-Respiratory Insufficiency', 'Mastocytosis, Systemic-characterized-Cardiomyopathy, Dilated', 'Mastocytosis, Systemic-characterized-Basal Ganglia Diseases', 'Mastocytosis, Systemic-characterized-Nervous System Malformations', 'Glucose-recommended-Muscle Weakness', 'Glucose-recommended-Hyponatremia', 'Nervous System Diseases-compromised-Respiratory Insufficiency', 'GDAP1-compromised-Respiratory Insufficiency', 'Exenatide-include-Nausea', 'Exenatide-include-Vomiting', 'Headache-include-Exenatide', 'Hypoglycemia-include-Exenatide', 'Neoplasms-associated-Heart Arrest', 'Heart Arrest-associated-Neoplasms', 'Epoprostenol-compare-Fibrosis', 'CDKN2B-associated-Heart Arrest', 'Heart Arrest-associated-CDKN2B', 'Central Nervous System Diseases-include-Hemorrhage', 'Heparin-increase-Hemorrhage', 'Heparin-increase-Central Nervous System Diseases', 'Heparin-increase-Death', 'Heparin-increase-Postphlebitic Syndrome', 'Breast Neoplasms-associated-Rectal Neoplasms', 'Rectal Neoplasms-associated-Breast Neoplasms', 'Breast Neoplasms-associated-SLC3A2', 'SLC3A2-associated-Breast Neoplasms', 'Prostatic Neoplasms-found-Neoplasms', 'KLK3-found-Neoplasms', 'Necrosis-target-Neoplasms', 'TNFSF10-target-Neoplasms', 'Infections-associated-Drug Hypersensitivity', 'Drug Hypersensitivity-associated-Infections', 'IL25-associated-Drug Hypersensitivity', 'Drug Hypersensitivity-associated-IL25', 'Cholesterol-recognized-Dementia', 'Cystic Fibrosis-result-Dehydration', 'Cystic Fibrosis-impair-CFTR', 'Opportunistic Infections-followed-Tuberculosis', 'Candidiasis-followed-Tuberculosis', 'Lymphoproliferative Disorders-associated-Epstein-Barr Virus Infections', 'Epstein-Barr Virus Infections-associated-Lymphoproliferative Disorders', 'Primary Immunodeficiency Diseases-associated-Epstein-Barr Virus Infections', 'Epstein-Barr Virus Infections-associated-Primary Immunodeficiency Diseases', 'SH2D1A-cause-Lymphoproliferative Disorders', 'Tauopathies-observed-Neurodegenerative Diseases', 'SH2D1A-cause-Primary Immunodeficiency Diseases', 'SH2D1A-associated-Epstein-Barr Virus Infections', 'Epstein-Barr Virus Infections-associated-SH2D1A', 'Glucose-slow-Diabetes Mellitus', 'Glucose-slow-Death', 'ISG15-associated-Neoplasms', 'Neoplasms-associated-ISG15', 'ISG15-associated-Carcinoma, Hepatocellular', 'Carcinoma, Hepatocellular-associated-ISG15', 'Epilepsy, Benign Neonatal-increase-Atherosclerosis', 'Liver Neoplasms-induce-Death', 'Glucose Metabolism Disorders-play-Colorectal Neoplasms', 'Weight Gain-implicated-Obesity', 'Metabolic Diseases-play-Colorectal Neoplasms', 'Weight Gain-review-Topiramate', 'Epilepsy, Benign Neonatal-characterised-Cholesterol', 'INS-play-Colorectal Neoplasms', 'Obesity-implicated-Topiramate', 'Weight Gain-review-Checkpoint Kinase 1', 'Obesity-implicated-Checkpoint Kinase 1', 'Sarcoma-followed-Cardiomyopathies', 'Neoplasms-followed-Cardiomyopathies', 'Doxorubicin-followed-Cardiomyopathies', 'Doxorubicin-result-Kidney Diseases', 'Death-observe-Pulmonary Disease, Chronic Obstructive', 'PIK3CD-observe-Pulmonary Disease, Chronic Obstructive', 'Leukemia-discuss-DYRK2', 'Leukemia, Myeloid-discuss-DYRK2', 'DYRK2-identified-Leukemia', 'Arthrogryposis-indicate-AIDS-Related Complex', 'Arthrogryposis-indicate-Spinocerebellar Ataxias', 'VPS33B-reported-Arthrogryposis', 'VPS33B-indicate-AIDS-Related Complex', 'VPS33B-indicate-Spinocerebellar Ataxias', 'Arthrogryposis-harbor-VPS33B', 'Kidney Diseases-harbor-VPS33B', 'Glioma-reveal-Neoplasms', 'ACAT1-reveal-Neoplasms', 'Neoplasms-influence-Breast Neoplasms', 'Genetic Diseases, X-Linked-associated-Sleep Apnea Syndromes', 'Sleep Apnea Syndromes-associated-Genetic Diseases, X-Linked', 'Neoplasms-hold-Neoplasm Metastasis', 'Genetic Diseases, X-Linked-caused-MECP2', 'MECP2-associated-Sleep Apnea Syndromes', 'Sleep Apnea Syndromes-associated-MECP2', 'Amyotrophic Lateral Sclerosis-produce-Gliosis', 'AQP4-associated-Amyotrophic Lateral Sclerosis', 'Amyotrophic Lateral Sclerosis-associated-AQP4', 'AQP4-produce-Gliosis', 'Emphysema-force-Death', 'ALB-force-Death', 'Anaphylaxis-lack-Cardiovascular Diseases', 'Anaphylaxis-avoid-ACE', 'Cardiovascular Diseases-avoid-ACE', 'CD4-detect-Death', 'Hemostatic Disorders-manifest-Aneurysm', 'Diabetes Mellitus-played-INS', 'INS-played-Hemostatic Disorders', 'Hemostatic Disorders-associated-INS', 'INS-associated-Hemostatic Disorders', 'INS-played-Aneurysm', 'INS-associated-Diabetic Nephropathies', 'Diabetic Nephropathies-associated-INS', 'INS-associated-Peripheral Arterial Disease', 'Peripheral Arterial Disease-associated-INS', 'Neoplasms-involve-Pancreatitis', 'Neoplasms-involve-INS', 'Neoplasms-used-Digestive System Neoplasms', 'Neoplasms-used-CEACAM3', 'Diabetes Mellitus-endstage-Renal Insufficiency', 'Mesothelioma-screened-CDKN2A', 'Pleural Diseases-screened-CDKN2A', 'Weight Loss-assess-Death', 'Neoplasms-short-Death', 'Retinal Diseases-associated-CD4', 'CD4-associated-Retinal Diseases', 'Weight Loss-assess-PTH', 'Cholesterol-short-Death', 'PTH-identify-Hyperparathyroidism', 'PTH-identify-Weight Loss', 'PTH-identify-Death', 'TARDBP-established-Amyotrophic Lateral Sclerosis', 'SCUBE2-upregulated-Diabetes Mellitus, Type 2', 'TARDBP-established-Epilepsy, Temporal Lobe', 'SCUBE2-upregulated-Dyslipidemias', 'Psoriasis-associated-Inflammatory Bowel Diseases', 'Inflammatory Bowel Diseases-associated-Psoriasis', 'Psoriasis-associated-Kidney Diseases', 'Kidney Diseases-associated-Psoriasis', 'Psoriasis-associated-INS', 'INS-associated-Psoriasis', 'UCP2-represent-Aneurysm', 'End Stage Liver Disease-include-Parkinson Disease', 'THPO-include-Parkinson Disease', 'CD320-contribute-Osteoporotic Fractures', 'CFTR-result-Urinary Retention', 'CFTR-result-Infections', 'CFTR-result-Inflammation', 'Oligodendroglioma-show-Seizures', 'EGFR-show-Seizures', 'Kidney Diseases-improve-Neoplasms', 'rs77375493-associated-Thrombosis', 'Thrombosis-associated-rs77375493', 'Thrombosis-develop-Polycythemia Vera', 'Pseudohypoparathyroidism-induced-Hypoxia', 'Pseudohypoparathyroidism-induced-EGLN3', 'EGLN3-induced-Hypoxia', 'AKT1-reduce-Kidney Diseases', 'AKT1-reduce-Infections', 'GH1-investigate-Death', 'GH1-investigate-Hypopituitarism', 'Infections-impair-EPO', 'Hyperparathyroidism-impair-EPO', 'ACE-lead-Proteinuria', 'ACE-lead-Heart Failure', 'ACE-lead-Cardiomyopathy, Hypertrophic', 'EPO-show-Anemia', 'EPO-contribute-Death', 'Leukemia, Myelogenous, Chronic, BCR-ABL Positive-serve-Neoplasms', 'EPO-represent-Spherocytosis, Hereditary', 'ZPR1-avert-Neurodegenerative Diseases', 'ZPR1-avert-Muscular Atrophy, Spinal', 'UTS2-induce-Heart Failure', 'Neoplasms-proposed-Pancreatic Neoplasms', 'Hereditary Breast and Ovarian Cancer Syndrome-associated-Neoplasms', 'Neoplasms-associated-Hereditary Breast and Ovarian Cancer Syndrome', 'Pancreatic Neoplasms-carry-BRCA2', 'Hereditary Breast and Ovarian Cancer Syndrome-associated-Pancreatic Neoplasms', 'Pancreatic Neoplasms-associated-Hereditary Breast and Ovarian Cancer Syndrome', 'Hemorrhage-prevent-Joint Diseases', 'Hemorrhage-prevent-Adrenal Insufficiency', 'Breast Neoplasms-impact-Cardiotoxicity', 'MIR455-implicated-Neoplasms', 'Doxorubicin-used-Breast Neoplasms', 'Joint Diseases-prevent-Adrenal Insufficiency', 'MIR455-implicated-Colorectal Neoplasms', 'MIR455-implicated-Prostatic Neoplasms', 'Adrenal Insufficiency-prevent-Joint Diseases', 'MIR455-implicated-Carcinoma, Hepatocellular', 'Hemorrhage-reduce-F8', 'MIR455-implicated-Kidney Neoplasms', 'Joint Diseases-prevent-F8', 'MIR455-implicated-Carcinoma, Squamous Cell', 'MIR455-implicated-Skin Neoplasms', 'F8-prevent-Joint Diseases', 'Thyroid Neoplasms-reduce-Death', 'PRKAB1-range-Metabolic Diseases', 'Thyroid Neoplasms-increase-SLC5A5', 'PRKAB1-range-Neoplasms', 'Muscular Diseases-associated-Arrhythmias, Cardiac', 'Arrhythmias, Cardiac-associated-Muscular Diseases', 'Muscular Diseases-include-Muscular Dystrophy, Emery-Dreifuss', 'Muscular Diseases-include-Myotonic Dystrophy', 'Arrhythmias, Cardiac-include-Muscular Dystrophy, Emery-Dreifuss', 'Arrhythmias, Cardiac-include-Myotonic Dystrophy', 'Arrhythmias, Cardiac-include-Muscular Diseases', 'Inflammation-contribute-Nerve Degeneration', 'Inflammation-contribute-Multiple Sclerosis', 'Demyelinating Diseases-cause-Nervous System Diseases', 'Demyelinating Diseases-cause-PLP1', 'Nerve Degeneration-described-PLP1', 'Nerve Degeneration-increase-PLP1', 'Lymphoma-characterized-CD5', 'Lymphoma-express-CD5', 'Eptifibatide-achieve-Heparin', 'Eptifibatide-receive-Heparin', 'Eptifibatide-achieve-Death', 'Cytomegalovirus Infections-involve-CD4', 'Eptifibatide-achieve-Ischemia', 'Death-receive-Eptifibatide', 'Ischemia-receive-Eptifibatide', 'INS-ameliorate-Retinal Diseases', 'INS-increase-Kidney Diseases', 'Hepatitis C, Chronic-recommended-Fibrosis', 'Hemophilia A-caused-Coagulation Protein Disorders', 'Kidney Diseases-lead-Renal Insufficiency', 'CD79A-lead-Renal Insufficiency', 'Cystic Fibrosis-demonstrate-Inflammation', 'Cystic Fibrosis-demonstrate-CFTR', 'Cardiotoxicity-restored-Cardiovascular Abnormalities', 'Breast Neoplasms-restored-Cardiovascular Abnormalities', 'Anthracyclines-restored-Cardiovascular Abnormalities', 'Trastuzumab-restored-Cardiovascular Abnormalities', 'Alzheimer Disease-accumulate-Plaque, Amyloid', 'Alzheimer Disease-cause-Tauopathies', 'Brain Neoplasms-increase-GH1', 'MAPT-accumulate-Plaque, Amyloid', 'Neoplasms-increase-GH1', 'MAPT-encode-Tauopathies', 'GH1-increase-Neoplasms', 'BAX-associated-Leukemia', 'Leukemia-associated-BAX', 'GH1-used-Neoplasms', 'GH1-treat-Neoplasms', 'GH1-used-Brain Neoplasms', 'GH1-treat-Brain Neoplasms', 'Muscle Weakness-supported-Meibomian Gland Dysfunction', 'Prostatic Neoplasms-prove-Mastocytosis, Systemic', 'Muscle Weakness-demonstrate-Neuromuscular Junction Diseases', 'Meibomian Gland Dysfunction-demonstrate-Neuromuscular Junction Diseases', 'KLK3-prove-Mastocytosis, Systemic', 'Neuromuscular Junction Diseases-demonstrate-MUSK', 'Infliximab-involved-Anemia', 'Neoplasms-associated-PTHLH', 'PTHLH-associated-Neoplasms', 'Hypercalcemia-associated-PTHLH', 'PTHLH-associated-Hypercalcemia', 'Metabolic Diseases-linked-Myocardial Infarction', 'Carcinoma, Squamous Cell-associated-PTHLH', 'PTHLH-associated-Carcinoma, Squamous Cell', 'Infliximab-involved-Breast Neoplasms', 'Fluticasone-Salmeterol Drug Combination-provide-Asthma', 'Fluticasone-Salmeterol Drug Combination-provide-Pulmonary Disease, Chronic Obstructive', 'Cardiovascular Diseases-assess-Weight Loss', 'INS-assess-Weight Loss', 'Heredodegenerative Disorders, Nervous System-caused-FXN', 'Inflammation-protect-Amyotrophic Lateral Sclerosis', 'ITPR2-protect-Inflammation', 'Neoplasms-inhibit-Weight Loss', 'Cachexia-inhibit-Weight Loss', 'Neoplasms-induced-Weight Loss', 'TNFRSF12A-express-Neoplasms', 'TNFRSF12A-cause-Cachexia', 'TNFRSF12A-extend-Cachexia', 'TNFRSF12A-inhibit-Weight Loss', 'HIV Infections-become-Neurodegenerative Diseases', 'Inflammation-become-Neurodegenerative Diseases', 'Neurodegenerative Diseases-measure-MAPT', 'PARK7-associated-Neoplasms', 'Neoplasms-associated-PARK7', 'PARK7-associated-Neurodegenerative Diseases', 'Neurodegenerative Diseases-associated-PARK7', 'PARK7-associated-Parkinson Disease', 'Parkinson Disease-associated-PARK7', 'Anemia, Hemolytic-used-EPO', 'Anemia-used-EPO', 'MTOR-link-Neoplasms', 'MTOR-link-Diabetes Mellitus', 'MTOR-link-Obesity', 'MTOR-link-Cardiovascular Diseases', 'MTOR-link-Nervous System Diseases', 'ALB-live-Coronary Artery Disease', 'ALB-live-Death', 'Liver Diseases-represent-Nucleosides', 'EPO-introduced-Brain Diseases', 'EPO-introduced-Chronic Disease', 'TP53-mediate-Heart Arrest', 'ALB-measured-Death', 'ALB-measured-Coronary Artery Disease', 'Proteinuria-develop-Doxorubicin', 'Gangliosidoses-lead-Central Nervous System Diseases', 'Heart Failure-require-INS', 'Gangliosidoses-lead-Death', 'Genetic Diseases, Inborn-lead-Central Nervous System Diseases', 'LRPPRC-associated-Leigh Disease', 'Leigh Disease-associated-LRPPRC', 'LRPPRC-associated-Neurodegenerative Diseases', 'Neurodegenerative Diseases-associated-LRPPRC', 'Genetic Diseases, Inborn-result-G(M2) Ganglioside', 'Heart Failure-regulate-Ventricular Remodeling', 'Heart Failure-regulate-INS', 'TP53-pathways-Neoplasms', 'Li-Fraumeni Syndrome-associated-Neoplasms', 'Neoplasms-associated-Li-Fraumeni Syndrome', 'Neoplasms-caused-TP53', 'Hereditary Breast and Ovarian Cancer Syndrome-caused-TP53', 'Hypoglycemia-associated-Death, Sudden', 'Death, Sudden-associated-Hypoglycemia', 'Glucose-associated-Death, Sudden', 'Death, Sudden-associated-Glucose', 'SCN1A-result-Epilepsies, Myoclonic', 'SCN1A-range-Epilepsies, Myoclonic', 'SCN1A-result-Epilepsy', 'SCN1A-range-Epilepsy', 'Diabetes Mellitus-result-Bone Marrow Diseases', 'Diabetes Mellitus-result-Ischemia', 'Streptozocin-result-Bone Marrow Diseases', 'Parkinson Disease-enhance-Drug-Related Side Effects and Adverse Reactions', 'Drug-Related Side Effects and Adverse Reactions-improve-Brain Neoplasms', 'Doxorubicin-reduce-Drug-Related Side Effects and Adverse Reactions', 'Exenatide-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-Exenatide', 'Exenatide-associated-Myocardial Infarction', 'Myocardial Infarction-associated-Exenatide', 'Doxorubicin-accumulate-Brain Neoplasms', 'Neoplasms-express-Neoplasm Metastasis', 'Neoplasms-express-EGFR', 'Diabetes Insipidus-associated-UBB', 'UBB-associated-Diabetes Insipidus', 'Esophageal Neoplasms-enhance-EGFR', 'HHEX-give-Diabetes Mellitus', 'HHEX-give-Pancreatitis', 'Liver Neoplasms-cause-Death', 'SOD1-cause-Death', 'Pulmonary Embolism-require-Pain', 'Obesity, Abdominal-increase-Atherosclerosis', 'Hemorrhage-require-Pain', 'Thrombophlebitis-require-Pain', 'CD34-harbor-rs113488022', 'Neoplasms, Neuroepithelial-show-CD34', 'Glioma-show-CD34', 'Neoplasms-show-CD34', 'INS-increase-Atherosclerosis', 'Niemann-Pick Disease, Type A-lead-Neurodegenerative Diseases', 'Niemann-Pick Disease, Type A-lead-Death', 'Niemann-Pick Disease, Type A-lead-Sphingomyelins', 'Death-inject-CD4', 'Immunologic Deficiency Syndromes-caused-Glycogen', 'Critical Illness-increase-Hemorrhage', 'Acute Kidney Injury-increase-Hemorrhage', 'Critical Illness-improve-Enoxaparin', 'Acute Kidney Injury-improve-Enoxaparin', 'Multiple Organ Failure-involve-Glycosaminoglycans', 'Motor Neuron Disease-remain-Neuromuscular Junction Diseases', 'Neuromuscular Junction Diseases-result-Quadriplegia', 'Neuromuscular Junction Diseases-remain-Quadriplegia', 'Neuromuscular Junction Diseases-remain-Metabolic Diseases', 'Glycosaminoglycans-remain-Neuromuscular Junction Diseases', 'Glycosaminoglycans-result-Quadriplegia', 'Hyperglycemia-occur-Chemical and Drug Induced Liver Injury', 'Hyperglycemia-occur-Pancreatitis', 'Hyperglycemia-occur-INS', 'Weight Loss-scored-Neoplasms', 'CRP-scored-Neoplasms', 'Hyperglycemia-lessen-Diabetes Mellitus', 'INS-coordinate-Glucose', 'INS-minimize-Hyperglycemia', 'INS-lessen-Diabetes Mellitus', 'Glucose-minimize-Hyperglycemia', 'Glucose-lessen-Diabetes Mellitus', 'HIV Infections-implicated-Tooth, Impacted', 'TAT-implicated-Tooth, Impacted', 'Mitochondrial Diseases-include-Hyperlysinemias', 'Mitochondrial Diseases-include-Immunologic Deficiency Syndromes', 'NADK2-associated-Mitochondrial Diseases', 'Mitochondrial Diseases-associated-NADK2', 'NADK2-associated-Hyperlysinemias', 'Hyperlysinemias-associated-NADK2', 'NADK2-include-Hyperlysinemias', 'Diabetes Mellitus, Type 1-impair-Kidney Diseases', 'NADK2-associated-Immunologic Deficiency Syndromes', 'Immunologic Deficiency Syndromes-associated-NADK2', 'NADK2-include-Immunologic Deficiency Syndromes', 'Acromegaly-impair-Kidney Diseases', 'Neoplasms-participate-Glioma', 'Seizures-induce-Headache', 'MTOR-induce-Mycophenolic Acid', 'MTOR-induce-Seizures', 'MTOR-induce-Headache', 'Mycophenolic Acid-induce-Headache', 'Acute Kidney Injury-forecast-Death', 'Glucose-forecast-Death', 'Prostatic Neoplasms-classified-Neoplasms', 'Prostatic Neoplasms-classified-KLK3', 'Diabetes Mellitus-perform-Dementia', 'Diabetes Mellitus-need-INS', 'INS-perform-Dementia', 'Craniosynostoses-include-GLIS3', 'Hernia, Hiatal-include-GLIS3', 'Heart Septal Defects, Atrial-include-GLIS3', 'Hearing Loss, Central-include-GLIS3', 'Exocrine Pancreatic Insufficiency-include-GLIS3', 'Coronary Artery Disease-prevent-Myocardial Infarction', 'Coronary Artery Disease-projected-Muscular Diseases', 'Lymphoma-delay-Cardiotoxicity', 'Myocardial Infarction-cause-Muscular Diseases', 'Anthracyclines-improve-Breast Neoplasms', 'Cholesterol-prevent-Myocardial Infarction', 'Anthracyclines-improve-Lymphoma', 'Anthracyclines-prevent-Cardiotoxicity', 'Carcinoma, Ehrlich Tumor-induce-Drug-Related Side Effects and Adverse Reactions', 'Doxorubicin-induce-Drug-Related Side Effects and Adverse Reactions', 'NF1-associated-Colonic Neoplasms', 'Colonic Neoplasms-associated-NF1', 'NF1-associated-Myelodysplastic Syndromes', 'Myelodysplastic Syndromes-associated-NF1', 'NF1-associated-Astrocytoma', 'Astrocytoma-associated-NF1', 'Retinal Degeneration-express-Amyotrophic Lateral Sclerosis', 'Arthritis, Rheumatoid-play-TNF', 'Autoimmune Diseases-play-TNF', 'Myeloproliferative Disorders-include-Polycythemia Vera', 'Myeloproliferative Disorders-described-JAK2', 'Polycythemia Vera-described-JAK2', 'AKT1-contribute-Atherosclerosis', 'AKT1-contribute-Diabetes Mellitus', 'Neoplasms-found-Neoplastic Syndromes, Hereditary', 'Oleic Acid-found-Neoplasms', 'GFAP-related-Neoplasms', 'GFAP-related-Necrosis', 'Alzheimer Disease-involve-MAPT', 'MUC16-predict-Death', 'MUC16-predict-Heart Failure', 'Neoplasms-include-Skin Neoplasms', 'Neoplasms-develop-BAP1', 'Breast Neoplasms-include-BAP1', 'Skin Neoplasms-include-BAP1', 'Neoplasms-known-Pancreatic Neoplasms', 'Neoplasms-include-BAP1', 'Doxorubicin-known-Neoplasms', 'Doxorubicin-known-Pancreatic Neoplasms', 'Colonic Neoplasms-suppress-Inflammation', 'Colonic Neoplasms-suppress-Carcinogenesis', 'Fatty Acids, Volatile-suppress-Inflammation', 'Fatty Acids, Volatile-suppress-Carcinogenesis', 'Fatty Acids-affect-Obesity', 'Fatty Acids-affect-Diabetes Mellitus', 'Fatty Acids-affect-Atherosclerosis', 'Fatty Acids-affect-Drug Hypersensitivity', 'Fatty Acids-affect-Neoplasms', 'Cell Transformation, Neoplastic-improve-Colorectal Neoplasms', 'SLCO2A1-promote-Dinoprostone', 'SLCO2A1-promote-Cell Transformation, Neoplastic', 'SLCO2A1-improve-Colorectal Neoplasms', 'Cell Transformation, Neoplastic-promote-Dinoprostone', 'Dinoprostone-improve-Colorectal Neoplasms', 'Neoplasms-involve-Sotos Syndrome', 'Neoplasms-involve-PTPA', 'Neoplasms-affected-PTPA', 'Sotos Syndrome-encode-PTPA', 'Thrombocythemia, Essential-associated-Thrombosis', 'Thrombosis-associated-Thrombocythemia, Essential', 'Thrombocythemia, Essential-associated-MPL', 'MPL-associated-Thrombocythemia, Essential', 'MPL-associated-Thrombosis', 'Thrombosis-associated-MPL', 'Neoplasms-develop-Hydrocephalus', 'TAT-associated-Neurologic Manifestations', 'Neurologic Manifestations-associated-TAT', 'Immunologic Deficiency Syndromes-characterized-Arbovirus Infections', 'DOCK8-characterized-Arbovirus Infections', 'Diabetes Mellitus-develop-Optic Atrophy', 'Lysosomal Storage Diseases-characterized-Demyelinating Diseases', 'Lysosomal Storage Diseases-characterized-Inflammation', 'Leukodystrophy, Globoid Cell-characterized-Demyelinating Diseases', 'Arthritis, Rheumatoid-implicated-Atherosclerosis', 'Leukodystrophy, Globoid Cell-characterized-Inflammation', 'Lysosomal Storage Diseases-characterized-Psychosine', 'Leukodystrophy, Globoid Cell-characterized-Psychosine', 'Seizures-related-Neoplasm Metastasis', 'Gallbladder Neoplasms-develop-Thrombosis', 'Topiramate-evaluate-Neoplasm Metastasis', 'Gallbladder Neoplasms-develop-EGFR', 'Thrombosis-develop-EGFR', 'Thalassemia-increase-Toxemia', 'Thalassemia-consider-Hemorrhage', 'Seizures-reduce-Topiramate', 'Neoplasm Metastasis-appear-Topiramate', 'SIRT1-antagonize-Heart Arrest', 'INS-support-Neuralgia', 'INS-alleviate-Neuralgia', 'INS-support-Diabetes Mellitus', 'INS-alleviate-Diabetes Mellitus', 'DMD-lead-Muscular Atrophy', 'DMD-lead-Heart Failure', 'Chromosome Aberrations-include-Breast Neoplasms', 'TP53-include-Breast Neoplasms', 'Cystic Fibrosis-tested-Agar', 'Acute Kidney Injury-compare-Critical Illness', 'Heparin-compare-Critical Illness', 'Peripheral Nervous System Diseases-observed-Diabetes Mellitus, Type 2', 'Coronary Artery Disease-observed-Diabetes Mellitus, Type 2', 'TSPO-evaluate-Neoplasms', 'TSPO-evaluate-Brain Neoplasms', 'Phosphoribosyl Pyrophosphate-rescue-Hyperuricemia', 'Carcinoma, Squamous Cell-enrol-Neoplasms', 'Genetic Diseases, X-Linked-caused-Hemophilia A', 'Genetic Diseases, X-Linked-caused-F8', 'ATXN3-show-Movement Disorders', 'ATXN3-show-Neurodegenerative Diseases', 'Communicable Diseases-accepted-Muscular Atrophy, Spinal', 'SMN1-ameliorate-Communicable Diseases', 'SMN1-accepted-Muscular Atrophy, Spinal', 'Cerebellar Ataxia-present-Fragile X Syndrome', 'Cerebellar Ataxia-present-Primary Ovarian Insufficiency', 'Sepsis-avoid-Cholestasis', 'Blind Loop Syndrome-avoid-Cholestasis', 'Fish Oils-avoid-Cholestasis', 'Parkinson Disease, Secondary-present-Fragile X Syndrome', 'Parkinson Disease, Secondary-present-Primary Ovarian Insufficiency', 'FABP4-seem-Cardiovascular Diseases', 'FABP4-seem-Obesity', 'FMR1-present-Cerebellar Ataxia', 'Ghrelin-improve-Nausea', 'Ghrelin-improve-Cachexia', 'Ghrelin-associated-Neoplasms', 'Neoplasms-associated-Ghrelin', 'rs1800795-observed-Alzheimer Disease', 'Intestinal Diseases-emphasize-Liver Diseases', 'Intestinal Diseases-emphasize-Inflammation', 'Intestinal Diseases-emphasize-Liver Failure', 'Liver Diseases-emphasize-Inflammation', 'FMR1-present-Parkinson Disease, Secondary', 'Inflammation-emphasize-Liver Failure', 'Intestinal Diseases-emphasize-Fish Oils', 'AGRP-associated-Fat Necrosis', 'Fat Necrosis-associated-AGRP', 'AGRP-associated-Diabetes Mellitus, Type 2', 'Diabetes Mellitus, Type 2-associated-AGRP', 'Death-reduce-Prostatic Neoplasms', 'Neoplasms-reduce-KLK3', 'KLK3-reduce-Death', 'KLK3-reduce-Prostatic Neoplasms', 'Diabetes Mellitus-progress-Hyperglycemia', 'Diabetes Mellitus-progress-INS', 'Hyperglycemia-progress-INS', 'Prostatic Neoplasms-integrate-KLK3', 'Diabetes Mellitus-increase-F8', 'Hypertension-increase-F8', 'F8-increase-Coronary Artery Disease', 'Fibrosis-caused-Hepatitis B', 'NFE2L2-treat-Inflammation', 'NFE2L2-treat-Cardiovascular Diseases', 'Diabetes Mellitus, Type 2-ameliorate-Chemical and Drug Induced Liver Injury', 'NFE2L2-treat-Kidney Diseases', 'INS-ameliorate-Diabetes Mellitus, Type 2', 'NFE2L2-treat-Lung Diseases', 'Diabetes Mellitus, Type 2-ameliorate-Glucose', 'NFE2L2-treat-Chemical and Drug Induced Liver Injury', 'NFE2L2-treat-Neoplasms', 'NFE2L2-treat-Diabetes Mellitus', 'NFE2L2-treat-Obesity', 'NFE2L2-treat-Sepsis', 'NFE2L2-treat-Autoimmune Diseases', 'NFE2L2-treat-Inflammatory Bowel Diseases', 'Diabetes Mellitus, Type 2-increased-Infections', 'Diabetes Mellitus, Type 2-vanish-Hyperglycemia', 'NFE2L2-prevent-Epilepsy', 'Infections-vanish-Hyperglycemia', 'Diabetes Mellitus, Type 2-vanish-INS', 'INS-increased-Infections', 'INS-vanish-Hyperglycemia', 'Diabetes Mellitus, Type 2-become-Autoimmune Diseases', 'INS-become-Autoimmune Diseases', 'Hemophilia A-contain-VWF', 'Diabetes Insipidus-develop-Hearing Loss', 'WFS1-develop-Diabetes Insipidus', 'Infections-linked-Hyperglycemia', 'Infliximab-link-Hypertension', 'Infliximab-link-Diabetes Mellitus', 'Diabetes Mellitus-suggest-Drug-Related Side Effects and Adverse Reactions', 'Meningeal Neoplasms-tend-Neoplasms', 'ARID1A-tend-Neoplasms', 'Infliximab-link-Dementia', 'ACE2-linked-Infections', 'ACE2-linked-Hyperglycemia', 'Renal Insufficiency, Chronic-identify-Kidney Diseases', 'Renal Insufficiency, Chronic-identify-Albuminuria', 'DKK3-identify-Renal Insufficiency, Chronic', 'DKK3-identify-Kidney Diseases', 'DKK3-identify-Albuminuria', 'Genetic Diseases, X-Linked-caused-DMD', 'Acromegaly-cause-Cardiomyopathies', 'Chronic Disease-raise-von Willebrand Diseases', 'Acromegaly-associated-Cardiomegaly', 'Cardiomegaly-associated-Acromegaly', 'Chronic Disease-raise-THBD', 'Acromegaly-ende-Heart Failure', 'Hematologic Neoplasms-link-Alzheimer Disease', 'Cardiomyopathies-cause-Hypotension', 'PICALM-link-Alzheimer Disease', 'Lysosomal Storage Diseases-lead-Immunologic Deficiency Syndromes', 'Cardiomyopathies-characterized-Heart Diseases', 'Cardiomyopathies-cause-Heart Diseases', 'ARSA-cause-Sulfoglycosphingolipids', 'Cardiomyopathies-characterized-Heart Failure', 'Cardiomyopathies-cause-Heart Failure', 'TRPA1-implicated-Cold Injury', 'TRPA1-implicated-Pain', 'Cardiomegaly-associated-Hypotension', 'Hypotension-associated-Cardiomegaly', 'Cardiomegaly-associated-Heart Diseases', 'Heart Diseases-associated-Cardiomegaly', 'Cardiomegaly-ende-Heart Failure', 'Lysosomal Storage Diseases-caused-ARSA', 'Hypotension-ende-Heart Failure', 'Heart Diseases-ende-Heart Failure', 'Leukodystrophy, Metachromatic-cause-Sulfoglycosphingolipids', 'Dwarfism, Pituitary-associated-Death', 'Death-associated-Dwarfism, Pituitary', 'Lysosomal Storage Diseases-cause-Sulfoglycosphingolipids', 'Immunologic Deficiency Syndromes-cause-Sulfoglycosphingolipids', 'Wiskott-Aldrich Syndrome-characterized-Thrombocytopenia', 'Wiskott-Aldrich Syndrome-characterized-Immunologic Deficiency Syndromes', 'Wiskott-Aldrich Syndrome-range-WAS', 'WAS-range-Thrombocytopenia', 'WAS-range-Immunologic Deficiency Syndromes', 'WAS-range-Eczema', 'Death-lead-Dyslipidemias', 'Obesity-lead-Dyslipidemias', 'Death-lead-INS', 'Neurologic Manifestations-recover-Infections', 'Lymphoproliferative Disorders-recover-Infections', 'CD8A-recover-Infections', 'SCN8A-associated-Movement Disorders', 'Movement Disorders-associated-SCN8A', 'Neurodegenerative Diseases-known-MAPT', 'MAPT-known-Tauopathies', 'Neurodegenerative Diseases-associated-Celiac Disease', 'Celiac Disease-associated-Neurodegenerative Diseases', 'Neurodegenerative Diseases-associated-TGM1', 'TGM1-associated-Neurodegenerative Diseases', 'TGM1-associated-Celiac Disease', 'Celiac Disease-associated-TGM1', 'Neurodegenerative Diseases-characterized-TGM1', 'Alzheimer Disease-characterized-TGM1', 'Cystic Fibrosis-lead-Liver Cirrhosis, Biliary', 'Parkinson Disease-characterized-TGM1', 'CFTR-lead-Liver Cirrhosis, Biliary', 'Paralysis-characterized-TGM1', 'Huntington Disease-characterized-TGM1', 'Mucopolysaccharidosis I-associated-Glycosaminoglycans', 'Glycosaminoglycans-associated-Mucopolysaccharidosis I', 'Lysosomal Storage Diseases-associated-Glycosaminoglycans', 'Glycosaminoglycans-associated-Lysosomal Storage Diseases', 'Corneal Diseases-cause-Mucopolysaccharidosis III', 'Corneal Diseases-cause-Mucopolysaccharidosis II', 'Dermatan Sulfate-cause-Corneal Diseases', 'Dermatan Sulfate-cause-Mucopolysaccharidosis III', 'Dermatan Sulfate-cause-Mucopolysaccharidosis II', 'FGF21-associated-Sugars', 'Sugars-associated-FGF21', 'FGF21-associated-Inflammation', 'Inflammation-associated-FGF21', 'FGF21-associated-Alzheimer Disease', 'Alzheimer Disease-associated-FGF21', 'Infections-indicate-Cytomegalovirus Infections', 'AKT1-required-Infections', 'AKT1-indicate-Cytomegalovirus Infections', 'AMH-determine-Ovarian Diseases', 'AMH-determine-Breast Neoplasms', 'Heart Diseases-result-Heart Failure', 'Death-related-von Hippel-Lindau Disease', 'Hyperphagia-develop-Cardiac Complexes, Premature', 'Hyperglycemia-develop-Cardiac Complexes, Premature', 'Weight Gain-develop-Cardiac Complexes, Premature', 'Diabetes Mellitus-develop-Cardiac Complexes, Premature', 'Anemia-observed-Huntington Disease', 'EPO-contribute-Anemia', 'INS-develop-Cardiac Complexes, Premature', 'Diabetes Mellitus-receive-Hypertension', 'ID1-upregulated-Melanoma', 'ID1-upregulated-Neoplasms', 'von Hippel-Lindau Disease-put-Neoplasms', 'Cholesterol-protect-Cardiovascular Diseases', 'Cholesterol-protect-Thromboembolism', 'Acromegaly-implicated-Diabetes Mellitus', 'Acromegaly-implicated-Kidney Diseases', 'GH1-termed-Acromegaly', 'GH1-implicated-Diabetes Mellitus', 'GH1-implicated-Kidney Diseases', 'Neoplasms-produce-Carcinoma, Non-Small-Cell Lung', 'Neoplasms-produce-Etoposide', 'Diabetes Mellitus, Type 1-range-Glucose', 'Cystic Fibrosis-range-Glucose', 'Bevacizumab-lead-Drug-Related Side Effects and Adverse Reactions', 'Hyperphosphatemia-induce-SIRT1', 'Vascular Calcification-induce-SIRT1', 'Immunologic Deficiency Syndromes-present-Mevalonate Kinase Deficiency', 'MVK-present-Mevalonate Kinase Deficiency', 'Paraganglioma-observed-Respiratory Insufficiency', 'SDHD-identified-Paraganglioma', 'SDHD-observed-Respiratory Insufficiency', 'HSPB8-play-Heredodegenerative Disorders, Nervous System', 'HSPB8-play-Genetic Diseases, Inborn', 'HSPB8-play-Alzheimer Disease', 'HSPB8-play-Pain Insensitivity, Congenital', 'Mitochondrial Encephalomyopathies-associated-TYMP', 'TYMP-associated-Mitochondrial Encephalomyopathies', 'Mitochondrial Diseases-associated-TYMP', 'TYMP-associated-Mitochondrial Diseases', 'PRG4-restore-Arthritis, Rheumatoid', 'LEP-associate-Prostatic Neoplasms', 'Prostatic Neoplasms-associate-LEP', 'LEP-associate-Lymphoma', 'Lymphoma-associate-LEP', 'Heart Diseases-prevent-Death', 'Heart Diseases-prevent-Cyclosporine', 'DKK1-associated-Osteoporosis', 'Osteoporosis-associated-DKK1', 'DKK1-associated-Arthritis, Rheumatoid', 'Arthritis, Rheumatoid-associated-DKK1', 'MAPT-buil-Alzheimer Disease', 'MAPT-buil-Neurodegenerative Diseases', 'PTEN-associated-Breast Neoplasms', 'Breast Neoplasms-associated-PTEN', 'Infections-lead-Immunologic Deficiency Syndromes', 'PTEN-associated-Neoplasm Metastasis', 'Neoplasm Metastasis-associated-PTEN', 'Neoplasms-become-Heart Diseases', 'Doxorubicin-become-Heart Diseases', 'BCL2L10-predict-Myelodysplastic Syndromes', 'BCL2L10-predict-Leukemia, Myeloid, Acute', 'Hyperglycemia-result-INS', 'Phosphatidylserines-compare-Hemoglobinuria, Paroxysmal', 'Phosphatidylserines-compare-Myelodysplastic Syndromes', 'Phosphatidylserines-show-Myelodysplastic Syndromes', 'Acromegaly-cause-Cardiomegaly', 'Acromegaly-associated-Hypotension', 'Hypotension-associated-Acromegaly', 'Cardiomyopathies-cause-Cardiomegaly', 'Glucose-recommended-Weight Loss', 'Glucose-present-Weight Loss', 'Glucose-present-Diabetes Mellitus', 'INS-remain-Diabetes Mellitus', 'INS-remain-Hyperglycemia', 'Anemia-related-Phospholipids', 'Hemolytic-Uremic Syndrome-related-Phospholipids', 'Obesity-affect-Dyslipidemias', 'Obesity-affect-Hypertension', 'Phospholipids-investigate-Hemolytic-Uremic Syndrome', 'Phospholipids-investigate-Anemia', 'GH1-associated-Hypercholesterolemia', 'Hypercholesterolemia-associated-GH1', 'Ventricular Dysfunction, Left-observed-Leuprolide', 'Hypotension-observed-Leuprolide', 'Death-include-Opportunistic Infections', 'Death-analyzed-APOE', 'Coronary Artery Disease-analyzed-APOE', 'Cerebrovascular Disorders-analyzed-APOE', 'Aneurysm-analyzed-APOE', 'Pneumonia-analyzed-APOE', 'Parkinson Disease-promote-Neoplasms', 'Heart Diseases-represent-Rhabdomyolysis', 'Death-represent-Rhabdomyolysis', 'TANGO2-represent-Heart Diseases', 'Colorectal Neoplasms-inactivate-Adenomatous Polyposis Coli', 'TANGO2-represent-Death', 'TANGO2-represent-Rhabdomyolysis', 'Hemangioblastoma-include-Neoplasms', 'Pheochromocytoma-include-Neoplasms', 'Neuroendocrine Tumors-include-Neoplasms', 'Endometrial Stromal Tumors-include-Neoplasms', 'VHL-develop-Neoplasms', 'Parkinson Disease-sensitize-Breast Neoplasms', 'VHL-develop-Hemangioblastoma', 'VHL-develop-Pheochromocytoma', 'VHL-develop-Neuroendocrine Tumors', 'VHL-implicated-Hemangioblastoma', 'VHL-implicated-Neoplasms', 'VHL-consist-Neoplasms', 'VHL-consist-Hemangioblastoma', 'VHL-consist-Pheochromocytoma', 'Docosahexaenoic Acids-associated-Stroke', 'Stroke-associated-Docosahexaenoic Acids', 'Docosahexaenoic Acids-inhibit-Obesity', 'Docosahexaenoic Acids-associated-Atherosclerosis', 'Atherosclerosis-associated-Docosahexaenoic Acids', 'Docosahexaenoic Acids-inhibit-Cardiovascular Diseases', 'HTT-culminate-Nerve Degeneration', 'HTT-culminate-Huntington Disease', 'Cystic Fibrosis-receive-INS', 'Neurodegenerative Diseases-include-Glucose', 'Cystic Fibrosis-cause-Inflammation', 'Cystic Fibrosis-cause-Infections', 'Ceramides-accumulate-Cystic Fibrosis', 'Ceramides-cause-Inflammation', 'Ceramides-cause-Infections', 'GCG-associated-Weight Loss', 'Weight Loss-associated-GCG', 'Acute Lung Injury-induced-Carrageenan', 'Lung Neoplasms-enhance-PWAR4', 'Hypercalcemia-differ-Neoplasms', 'Epilepsy, Benign Neonatal-progress-Coronary Artery Disease', 'Death-progress-Coronary Artery Disease', 'Cholesterol-progress-Coronary Artery Disease', 'PTHLH-differ-Neoplasms', 'Cholesterol-compared-Blindness', 'Cholesterol-compared-Retinitis', 'Nerve Degeneration-observed-Huntington Disease', 'RAB4A-highlight-Nerve Degeneration', 'RAB4A-explored-Nerve Degeneration', 'RAB4A-highlight-Huntington Disease', 'RAB4A-observed-Huntington Disease', 'Glucose-demonstrate-Hypoglycemia', 'Glycogen-cause-Muscle Weakness', 'Glycogen-cause-Cardiomyopathies', 'KRAS-occur-Neoplasms', 'KRAS-occur-Carcinoma, Pancreatic Ductal', 'Myositis Ossificans-characterized-Abnormalities, Drug-Induced', 'Myositis Ossificans-characterized-Ossification, Heterotopic', 'Myositis Ossificans-characterized-ACVR1', 'Pain-occur-Tramadol', 'Drug-Related Side Effects and Adverse Reactions-occur-Tramadol', 'Cardiotoxicity-occur-Tramadol', 'Fractures, Bone-range-Tramadol', 'Death-tend-Glucose', 'Infections-tend-Glucose', 'Acromegaly-correct-GH1', 'Neoplasms-correct-GH1', 'Glucose-tend-Death', 'Glucose-correlate-Death', 'Huntington Disease-improve-Chorea', 'Huntington Disease-improve-Valproic Acid', 'Valproic Acid-improve-Chorea', 'ACHE-include-Alzheimer Disease', 'ACHE-alleviate-Neurotoxicity Syndromes', 'Cardiovascular Diseases-screened-Diabetes Mellitus', 'Teriparatide-prevent-Fractures, Bone', 'HIV Infections-increase-Acquired Immunodeficiency Syndrome', 'Teriparatide-increase-Osteoporosis', 'Infections-increase-Acquired Immunodeficiency Syndrome', 'rs80356743-experience-Amyotrophic Lateral Sclerosis', 'Diabetes Mellitus-reduce-Albuminuria', 'REN-reduce-Albuminuria', 'Acquired Immunodeficiency Syndrome-include-Parasitic Diseases', 'Polysaccharides-increase-Parasitic Diseases', 'Polysaccharides-increase-Acquired Immunodeficiency Syndrome', 'Polysaccharides-prevent-Neoplasms', 'Polysaccharides-prevent-Neoplasm Metastasis', 'RUNX1-confer-DNMT3A', 'RUNX1-confer-IDH2', 'BDNF-result-IL6', 'DNAJB6-recruit-HSPA8', 'MAPKAPK3-control-MAPK1', 'MAPKAPK3-result-EZH2', 'NFE2L2-work-PRDX2', 'NFE2L2-work-TXN', 'NFE2L2-work-PRDX1', 'BMI1-suppress-CDKN2A', 'EZH2-suppress-CDKN2A', 'MAPKAPK3-support-BMI1', 'CD151-do-RHOA', 'MOB4-activate-YAP1', 'IRF1-decrease-MTMR2', 'STAT1-increased-MTMR2', 'MTMR2-accompany-ZEB1', 'HGF-activate-SLTM', 'SIRT1-function-FOXO3', 'AKT1-bear-ITGB4', 'AKT1-express-ITGB4', 'DEAF1-correlate-TP53', 'HSF1-block-BAG3', 'HSF1-induce-HSP90AA1', 'BRCA1-reduced-BRCA2', 'NUAK2-play-YAP1', 'ASXL1-include-CALR', 'EZH2-include-CALR', 'SRSF2-include-CALR', 'E2F2-correlate-VIM', 'E2F2-correlate-ADGRE2', 'HDAC2-initiated-TWIST1', 'FUS-harbour-ANG', 'ETS1-base-CDKN2A', 'ETS2-base-CDKN2A', 'BCL2-associated-TP53', 'TP53-associated-BCL2', 'APP-increase-TAT', 'SIRT1-use-PPARA', 'HLCS-interact-DNMT1', 'HLCS-interact-MECP2', 'DISC1-show-NDEL1', 'NDEL1-interact-FEZ1', 'DISC1-show-PDE4B', 'DISC1-interact-FEZ1', 'ETNPPL-verify-STMN2', 'ETNPPL-verify-STMN1', 'SLC5A2-appear-SLC5A1', 'PTK2-downregulate-MMP9', 'PTK2-reduce-MMP9', 'MMP2-downregulate-PTK2', 'AXL-downregulate-PTK2', 'EIF2AK3-persist-TLR9', 'SIRT1-include-PTPN1', 'SIRT1-identified-PTPN1', 'SIRT1-include-PRKAA2', 'SIRT1-identified-PRKAA2', 'INS-improve-SIRT1', 'SIRT1-identify-INS', 'AR-improve-INS', 'SERPINA1-prevent-ELN', 'WWOX-bind-MAPT', 'WWOX-bind-MAPK8', 'WWOX-bind-MAPK1', 'HNRNPM-interact-MATR3', 'TNF-understood-TNFRSF1A', 'TNF-signal-TNFRSF1B', 'TNFRSF1A-trigger-TNFRSF1B', 'TNF-signal-TNFRSF1A', 'NFKBIZ-recruit-RELA', 'FOXO1-elicited-INS', 'RUNX1-carry-DNMT3A', 'EGFR-show-ALK', 'ASXL1-carry-RUNX1', 'HES1-involved-SLC2A3', 'HES1-involved-PGK1', 'HES1-involved-TIGAR', 'HES1-involved-SCO2', 'VEGFA-require-GH1', 'VEGFA-undergo-GH1', 'VASP-colocalized-ZYX', 'ZYX-colocalized-VASP', 'FAM135B-promote-GRN', 'INS-implicated-MAPT', 'FBXW7-populated-NFKB2', 'FBXW7-populated-NOTCH1', 'FBXW7-populated-STYX', 'MRC1-inhibit-AKT1', 'ARG1-inhibit-AKT1', 'FBXW7-populated-GPR27', 'FBXW7-populated-CCNE1', 'FBXW7-populated-CUL1', 'FBXW7-populated-SKP1', 'YARS1-induce-PARP1', 'YARS1-promote-PARP1', 'FBXL2-recognize-NLRP3', 'FBXO3-restore-FBXL2', 'FBXO3-restore-NLRP3', 'NLRP3-uncover-FBXL2', 'NR2E1-bind-CBX7', 'CBX7-identify-NR2E1', 'FBXO3-target-FBXL2', 'NLRP3-target-FBXL2', 'CBX7-repress-NR2E1', 'NR2E1-regulate-CBX7', 'WIPI1-assist-WIPI2', 'WIPI2-assist-GABARAP', 'WIPI2-assist-MAP1LC3A', 'WIPI2-assist-ATG16L1', 'WIPI2-recruit-ATG16L1', 'WIPI1-recruit-ATG16L1', 'MYC-bind-WIPI1', 'NUP62-elevated-TARDBP', 'SMN1-expressed-SMN2', 'CXCR4-co-expressed-POU5F1', 'TAT-lead-PTEN', 'NCS1-recognized-KAT2B', 'FZD2-recognized-KAT2B', 'COL5A1-recognized-KAT2B', 'DNM3-result-LDLR', 'PRKAB1-attenuate-MAPT', 'SIRT1-contribute-INS', 'ADIPOQ-contribute-INS', 'KIR3DL1-activate-KIR2DS4', 'KIR2DL1-activate-KIR2DS4', 'FIS1-decrease-SIRT3', 'FIS1-improve-SIRT3', 'UTRN-decrease-SIRT3', 'UTRN-improve-SIRT3', 'SIRT1-reported-TP53', 'SIRT1-downregulate-TP53', 'BCL2-overexpress-MYF6', 'BCL2-overexpress-MYOD1', 'JAK2-activate-STAT5A', 'EGFR-attributed-KRAS', 'EDNRB-mediated-VEGFA', 'EDNRB-mediated-NGF', 'CCND2-protect-FBXL2', 'FBXL2-decrease-CCND2', 'FBXL2-target-CCND2', 'ZEB1-reinforced-ZEB2', 'SNAI1-reinforced-ZEB2', 'ZEB2-play-FOXC2', 'BUB1-depend-TP53', 'TP53-monitor-BUB1', 'HGF-modify-AKT1', 'CDKN2A-bind-CDK4', 'CDKN2A-bind-CDK6', 'ACVR2A-seen-ACVR2B', 'SMN1-range-SMN2', 'IDE-associated-INS', 'INS-associated-IDE', 'CDK19-replace-CDK8', 'INSL3-act-RXFP2', 'BRCA1-test-BRCA2', 'CCND1-identify-KLF8', 'E2F1-induce-SIRT1', 'SIRT1-increase-E2F1', 'SIRT1-bind-E2F1', 'FASLG-studied-CASP3', 'SIRT7-collaborate-HDAC3', 'HDAC4-increase-SIRT1', 'PTEN-associated-IGF2', 'IGF2-associated-PTEN', 'IVL-decreased-PI3', 'SPRR1B-decreased-PI3', 'STAT1-down-regulate-BST2', 'BMI1-express-TERT', 'CHEK2-activate-TP53', 'MLF1-associate-HAX1', 'HAX1-associate-MLF1', 'MLF1-associate-HTRA2', 'HTRA2-associate-MLF1', 'MLF1-displace-HTRA2', 'HAX1-generated-PARL', 'SIRT1-regulate-FOXO1', 'SIRT1-control-FOXO1', 'SWI5-include-NLRP11', 'SWI5-include-CENPE', 'SWI5-include-ELAVL2', 'ARHGAP24-bind-ARF6', 'ISG15-sequester-XIAP', 'ARHGAP24-require-ARF6', 'ATR-contribute-ATRIP', 'PTEN-found-TAT', 'TAT-compete-TP53', 'PTEN-compete-TP53', 'MAP3K7-suppress-AKT1', 'MCHR1-upregulate-CCN2', 'MCHR1-upregulate-TGFB1', 'MCHR1-promote-CCN2', 'SIRT6-associated-TP53BP1', 'TP53BP1-associated-SIRT6', 'SIRT6-induce-TP53BP1', 'VCAM1-share-PROM1', 'ALCAM-share-PROM1', 'SMN2-confirm-SMN1', 'USP28-satisfy-USP25', 'USP28-exhibit-USP25', 'INS-decrease-IGFBP2', 'ZFAND2A-identify-ZFAND2B', 'PPP1R13B-target-TP53I3', 'BRCA2-impair-RAD51', 'COL11A2-target-BRCA2', 'TARDBP-augment-SMN1', 'CD79A-reveal-C3', 'HSP90B1-considered-CFTR', 'LMNA-considered-CFTR', 'MAGEA10-bind-MAGEA4', 'UTRN-lead-MFN2', 'MFN2-fail-UTRN', 'ARHGEF12-identify-WTIP', 'LRPPRC-interact-MAP1S', 'TXNIP-lead-TP53', 'VEGFA-identify-PTEN', 'NCF1-enhance-CYBB', 'TIAM1-regulate-RAC1', 'APOB-consider-ULK1', 'APOB-consider-ATG7', 'APOB-consider-ATP5F1A', 'WDR73-described-LAGE3', 'WDR73-described-OSGEP', 'WDR73-described-TP53RK', 'WDR73-described-TPRKB', 'WDR73-identified-TPRKB', 'VPS37A-decrease-EGFR', 'VPS37A-lead-EGFR', 'LPL-associated-ZAP70', 'ZAP70-associated-LPL', 'DOCK8-diminish-CD8A', 'CD8A-compromised-DOCK8', 'INS-fast-SHBG', 'INS-influence-SHBG', 'INS-attenuated-SHBG', 'MTOR-reduce-RPS6KB1', 'MAPK3-modified-ISG15', 'JAK1-modified-ISG15', 'SMN1-known-SQSTM1', 'NPC1-encode-PDGFB', 'STAT1-bind-TET2', 'JAK2-harbor-SH2B3', 'JAK2-harbor-ASXL1', 'JAK2-harbor-TET2', 'JAK2-harbor-IKZF1', 'SPRR1B-occur-IVL', 'YARS2-stimulate-PARP1', 'TNFSF10-upregulated-CBX7', 'EGFR-reshape-AKT1', 'INPP5D-recruited-AKT1', 'INPP5D-mediate-HSPB1', 'INPP5D-mediate-EGFR', 'EGFR-mediate-AKT1', 'CPEB1-surmise-TENT2', 'CPEB1-enhance-TENT2', 'INS-inhibit-AKT1', 'PKM-follow-PRRT2', 'SIRT1-influence-RUNX2', 'VAPB-interact-FAF1', 'SIRT1-increase-ADIPOQ', 'KLRG1-enhance-IL2', 'IL6-involved-CRP', 'IL2-compare-CRP', 'USP7-stabilize-ABCB1', 'USP7-interact-ABCB1', 'RB1-down-regulate-KCNH1', 'SMN1-increase-SMN2', 'C4BPA-modulate-IL1B', 'VEGFA-modulate-IL1B', 'SMN1-encode-SMN2', 'SMN2-express-SMN1', 'SIRT1-result-ROCK1', 'THBD-correlate-VWF', 'FGF23-play-INS', 'EGF-inhibit-CDCP1', 'EGF-include-CDCP1', 'IL7R-correlate-BCL2', 'IL7R-correlate-IL2', 'IL7R-correlate-CXCR4', 'IL7R-correlate-CCR7', 'NTRK2-shown-BDNF', 'INS-manifest-GCG', 'RGS3-reduce-C5AR1', 'C5AR1-regulate-RGS3', 'MYT1L-prevent-ID1', 'MYT1L-coincide-ID1', 'MYT1L-coincide-ID3', 'Sugars-include-Glucose', 'Sugars-include-Fructose', 'Sugars-include-Lactose', 'Sugars-include-Sucrose', 'Sugars-include-Maltose', 'Enoxaparin-given-Heparin', 'Glucose-compare-Sucrose', 'Icodextrin-illustrate-Glucose', 'Anthracyclines-replaced-Doxorubicin', 'Anthracyclines-replaced-Etoposide', 'Doxorubicin-replaced-Etoposide', 'Heparin-cause-Glucosamine', 'Heparin-cause-Hyaluronic Acid', 'Heparin-suppress-Hyaluronic Acid', 'Phosphatidylinositols-include-Phospholipids', 'Phosphatidylcholines-include-Phospholipids', 'Phosphatidylserines-include-Phospholipids', 'Sphingolipids-involved-Fatty Acids', 'Phosphatidylserines-comprise-Phospholipids', 'Phospholipids-confined-Phosphatidylserines', 'Fatty Acids-attenuate-Triglycerides', 'Cholesterol-convert-Hydroxycholesterols', 'Fatty Acids-result-Oleic Acid', 'Fatty Acids-result-Linoleic Acid', 'Oleic Acid-result-Linoleic Acid', 'Oleic Acids-result-Oleic Acid', 'Oleic Acids-result-Linoleic Acid', 'Cholesterol-reduce-Triglycerides', 'Fatty Acids, Monounsaturated-include-Fatty Acids', 'Fatty Acids, Omega-6-include-Fatty Acids', 'Fatty Acids, Omega-3-include-Fatty Acids', 'Cholesterol-calculated-Sterols', 'Epoprostenol-stimulated-Arachidonic Acid', 'Insulin Glargine-increase-Insulin Detemir', 'Eicosapentaenoic Acid-treated-Fatty Acids, Omega-3', 'Ranibizumab-confer-Bevacizumab', 'Infliximab-applied-Adalimumab', 'Hemophilia A-end-Hemorrhage', 'Joint Diseases-end-Hemorrhage', 'Primary Immunodeficiency Diseases-known-Metabolism, Inborn Errors', 'Primary Immunodeficiency Diseases-characterized-Infections', 'Metabolism, Inborn Errors-known-Genetic Diseases, Inborn', 'Metabolism, Inborn Errors-characterized-Infections', 'Acute Kidney Injury-followed-Nephrotic Syndrome', 'Anemia-range-Hyalinosis, Systemic', 'Obesity-considered-Psoriasis', 'Tuberculosis-contribute-Death', 'HIV Infections-follow-Tuberculosis', 'Tuberculosis-follow-Acquired Immunodeficiency Syndrome', 'Tuberculosis-contribute-Acquired Immunodeficiency Syndrome', 'Sleep Deprivation-associated-Dementia', 'Dementia-associated-Sleep Deprivation', 'Chronic Disease-lead-Obesity', 'Leukemia, Myelogenous, Chronic, BCR-ABL Positive-overcome-Drug-Related Side Effects and Adverse Reactions', 'Cardiac Output, Low-improve-Fatigue', 'Diabetes Mellitus-show-Drug-Related Side Effects and Adverse Reactions', 'Inflammation-cause-Cerebrovascular Disorders', 'Pancreatitis-become-Diabetes Mellitus', 'Inflammation-cause-Hypertension, Pulmonary', 'Lung Neoplasms-metastasize-Neoplasm Metastasis', 'Melanoma-metastasize-Neoplasm Metastasis', 'Pigmentation Disorders-known-Neurofibroma', 'Hypophosphatemia-lead-Limb Deformities, Congenital', 'Hypophosphatemia-lead-Osteomalacia', 'Myasthenia Gravis-fell-Muscular Dystrophies', 'Wounds and Injuries-enrol-Fractures, Compression', 'Neoplasms-revise-Spinal Injuries', 'Heterotaxy Syndrome-provide-Stroke', 'Infections-remain-Liver Diseases', 'HIV Infections-achieve-Opportunistic Infections', 'Drug-Related Side Effects and Adverse Reactions-consider-Lymphoma', 'Graft vs Host Disease-treat-Neoplasms', 'Oculocerebrorenal Syndrome-suffer-Renal Insufficiency, Chronic', 'Hemolysis-play-Pain', 'Renal Insufficiency, Chronic-lead-Urolithiasis', 'Hypothyroidism-associated-Sexual Dysfunction, Physiological', 'Sexual Dysfunction, Physiological-associated-Hypothyroidism', 'Hyperthyroidism-associated-Sexual Dysfunction, Physiological', 'Sexual Dysfunction, Physiological-associated-Hyperthyroidism', 'Idiopathic Pulmonary Fibrosis-include-Pulmonary Fibrosis', 'Death-associated-Idiopathic Pulmonary Fibrosis', 'Idiopathic Pulmonary Fibrosis-associated-Death', 'Heart Failure-improve-Cardiomyopathies', 'Exanthema-last-Nausea', 'Exanthema-last-Diarrhea', 'Neoplasms-interact-Fatigue', 'Drug Hypersensitivity-last-Nausea', 'Drug Hypersensitivity-last-Diarrhea', 'Nausea-last-Diarrhea', 'Nausea-last-Tachycardia, Paroxysmal', 'Nausea-last-Weight Loss', 'Nausea-last-Pain', 'Nausea-last-Hematologic Diseases', 'Nausea-last-Liver Failure', 'Nausea-last-Eosinophilia', 'Diarrhea-last-Tachycardia, Paroxysmal', 'Diarrhea-last-Weight Loss', 'Diarrhea-last-Pain', 'Diarrhea-last-Hematologic Diseases', 'Obesity-undergo-Spinal Diseases', 'Diarrhea-last-Liver Failure', 'Diarrhea-last-Eosinophilia', 'Colorectal Neoplasms-associated-Adenomatous Polyposis Coli', 'Adenomatous Polyposis Coli-associated-Colorectal Neoplasms', 'Lysosomal Storage Diseases-caused-Mucopolysaccharidosis VII', 'Death-related-Kidney Failure, Chronic', 'Muscular Diseases-implicated-Movement Disorders', 'Alzheimer Disease-constitute-Hydrocephalus', 'Dementia-constitute-Hydrocephalus', 'Amyotrophic Lateral Sclerosis-arise-TDP-43 Proteinopathies', 'Cardiovascular Diseases-described-Death', 'Amyotrophic Lateral Sclerosis-lead-Drug-Related Side Effects and Adverse Reactions', 'Escherichia coli Infections-form-Fibrosis', "Death-caused-Legionnaires' Disease", 'Escherichia coli Infections-potentiated-Immunologic Deficiency Syndromes', "Death-recorded-Legionnaires' Disease", 'Escherichia coli Infections-protected-Pyelonephritis', 'Immunologic Deficiency Syndromes-protected-Pyelonephritis', "Legionnaires' Disease-match-Death", 'Dysbiosis-implicated-Coronaviridae Infections', 'Dysbiosis-implicated-Obesity', 'Dysbiosis-implicated-Inflammation', 'Obesity-include-Coronaviridae Infections', 'Inflammation-include-Coronaviridae Infections', 'Death-analysed-Heart Diseases', 'Heart Failure-follow-Neoplasms', 'Heart Failure-outnumber-Heart Diseases', 'Heart Failure-outnumber-Death', 'Infections-live-HIV Infections', 'Heart Diseases-outnumber-Death', 'HIV Infections-prevent-Cardiovascular Diseases', 'Neoplasms-maintain-Seizures', 'Neoplasms-diminish-Fatigue', 'Seizures-diminish-Fatigue', 'Death-caused-Pneumoconiosis', 'Neoplasms-become-Drug Hypersensitivity', 'Death-caused-Lung Neoplasms', 'Hypertension, Malignant-lead-Hypertension', 'Death-caused-Pulmonary Heart Disease', 'Inflammation-become-Drug Hypersensitivity', 'Cystic Fibrosis-become-Drug Hypersensitivity', 'Diabetes Mellitus-become-Drug Hypersensitivity', 'Critical Illness-indicated-Ischemia', 'Kidney Failure, Chronic-manage-Critical Illness', 'Pituitary Neoplasms-cause-Acromegaly', 'Pituitary Neoplasms-secrete-Neoplasms', 'Acromegaly-cause-Adenoma', 'Neoplasms-observed-Leukemia', 'Neoplasms-observed-Multiple Myeloma', 'Prolactinoma-secrete-Neoplasms', 'Adenoma-secrete-Neoplasms', 'Cardiovascular Diseases-required-Death', 'Neoplasms-increased-Neurodegenerative Diseases', 'Neurodegenerative Diseases-increased-Atherosclerosis', 'Aneurysm-categorize-Vascular Neoplasms', 'Aneurysm-categorize-Abnormalities, Drug-Induced', 'Glucose Metabolism Disorders-relate-Alzheimer Disease', 'Neoplasms-contribute-Colorectal Neoplasms', 'Ovarian Neoplasms-compare-Drug Hypersensitivity', 'Headache Disorders, Secondary-attributed-Facial Dermatoses', 'Headache Disorders, Secondary-attributed-Sleep Apnea, Obstructive', 'Shy-Drager Syndrome-associated-Death', 'Death-associated-Shy-Drager Syndrome', 'Pain-follow-Necrosis', 'Death-contribute-Obesity', 'HIV Infections-exhibit-Frailty', 'Frailty-associated-Inflammation', 'Inflammation-associated-Frailty', 'Prostatic Neoplasms-divided-Death', 'Death-catch-Polycystic Ovary Syndrome', 'Cerebral Infarction-saved-Subarachnoid Hemorrhage', 'Death-evaluate-Stroke', 'Kidney Diseases-develop-Kidney Failure, Chronic', 'Lupus Nephritis-associated-Death', 'Death-associated-Lupus Nephritis', 'Neoplasms, Multiple Primary-result-Necrosis', 'Neoplasms, Multiple Primary-result-Fibrosis', 'Fibrosis-lead-Respiratory Insufficiency', 'Muscular Dystrophies-characterized-Muscular Atrophy', 'Muscular Dystrophies-characterized-Retinal Degeneration', 'Genetic Diseases, Inborn-characterized-Muscular Atrophy', 'Genetic Diseases, Inborn-characterized-Retinal Degeneration', 'Death-increase-Familial Primary Pulmonary Hypertension', 'Stroke-included-Diabetes Mellitus', 'Diabetes Mellitus-included-Hypotension', 'Endocrine System Diseases-manifest-Diabetes Insipidus', 'Diabetes Mellitus-develop-Nervous System Diseases', 'Diabetes Mellitus-develop-Atherosclerosis', 'Renal Insufficiency-managed-Bone Neoplasms', 'Renal Insufficiency-managed-Anemia', 'Hypoxia-drive-Fasciculation', 'Hypoxia-drive-Pulmonary Disease, Chronic Obstructive', 'Neurologic Manifestations-permit-Late Onset Disorders', 'Eclampsia-include-Hypertension', 'Neurologic Manifestations-improve-Huntington Disease', 'Ovarian Diseases-induce-Primary Ovarian Insufficiency', 'Neutropenia-prevent-Breast Neoplasms', 'Autoimmune Diseases-observed-Turner Syndrome', 'Turner Syndrome-appear-Thyroiditis, Autoimmune', 'Turner Syndrome-observed-Inflammatory Bowel Diseases', 'Mitral Valve Insufficiency-progress-Heart Failure', 'Mitral Valve Insufficiency-progress-Death', 'Coronary Artery Disease-stay-Death', 'Coronary Artery Disease-go-Pulmonary Disease, Chronic Obstructive', 'Coronary Artery Disease-go-Lung Neoplasms', 'Death-go-Pulmonary Disease, Chronic Obstructive', 'Death-go-Lung Neoplasms', 'Pulmonary Disease, Chronic Obstructive-go-Lung Neoplasms', 'Arachnodactyly-noted-Musculoskeletal Diseases', 'Obesity-increase-Erectile Dysfunction', 'Erectile Dysfunction-tend-Hypertension', 'Neoplasms-exist-Carcinogenesis', 'Cardiovascular Diseases-prevent-Sexual Dysfunction, Physiological', 'Death-prevent-Sexual Dysfunction, Physiological', 'Amyotrophic Lateral Sclerosis-characterized-Respiratory Paralysis', 'Death-associated-Leukemia, Myelogenous, Chronic, BCR-ABL Positive', 'Leukemia, Myelogenous, Chronic, BCR-ABL Positive-associated-Death', 'Myocardial Infarction-used-Ischemia', 'Myocardial Infarction-underlie-Coronary Artery Disease', 'Ischemia-underlie-Coronary Artery Disease', 'Fractures, Bone-prevent-Neoplasms', 'Neoplasm Metastasis-treat-Fractures, Bone', 'Myocardial Infarction-survive-Cardiovascular Diseases', 'Myocardial Infarction-survive-Death', 'Opportunistic Infections-include-HIV Infections', 'Cardiomyopathies-based-Heart Failure', 'Cardiomyopathies-use-Heart Failure', 'Muscle Weakness-hast-Death', 'Colitis, Ulcerative-develop-Neoplasms', 'Intermittent Claudication-lead-Aortitis', 'Intermittent Claudication-cause-Aneurysm', 'Gangrene-lead-Aortitis', 'Gangrene-cause-Aneurysm', 'Aortitis-lead-Aneurysm', 'Leukocytosis-identified-Thrombosis', 'Death-range-Wounds and Injuries', 'Vision Disorders-predict-Alzheimer Disease', 'Vision Disorders-use-Dementia', 'Vision Disorders-use-Alzheimer Disease', 'Lung Neoplasms-calculated-Diabetes Mellitus', 'Ocular Hypertension-advances-Cataract', 'Lung Neoplasms-compare-Diabetes Mellitus', 'Neoplasms-lead-Neoplasm Metastasis', 'Weight Loss-improve-Death', 'Thromboembolism-include-Death', 'Capillary Leak Syndrome-include-Death', 'Thrombosis-include-Death', 'Endocarditis-include-Death', 'Hemorrhage-treat-Amyloidosis', 'Torsades de Pointes-treat-Atrial Fibrillation', 'Colorectal Neoplasms-screen-Hemochromatosis', 'Atrial Fibrillation-alter-Heart Failure', 'Myocardial Infarction-credited-Heart Diseases', 'Myocardial Infarction-credited-Heart Failure', 'Abnormalities, Drug-Induced-seen-Turner Syndrome', 'Hypogonadism-found-Turner Syndrome', 'Abnormalities, Drug-Induced-dissect-Aneurysm', 'HIV Infections-range-Dementia', 'Turner Syndrome-dissect-Aneurysm', 'Death-increased-Turner Syndrome', 'Hypothyroidism-increased-Diabetes Mellitus', 'Death-confirm-Nervous System Diseases', 'Pneumonia-rise-Death', 'Motor Neuron Disease-caused-Amyotrophic Lateral Sclerosis', 'Huntington Disease-develop-Nervous System Diseases', 'Huntington Disease-resemble-Nervous System Diseases', 'Parkinson Disease-examine-Nervous System Diseases', 'Heart Failure-directed-Dyspnea', 'Drug-Related Side Effects and Adverse Reactions-include-Hypotension', 'Death-reverse-Heart Defects, Congenital', 'Drug-Related Side Effects and Adverse Reactions-include-Dyspnea', 'Drug-Related Side Effects and Adverse Reactions-include-Chest Pain', 'Neutropenia-contribute-Death', 'Dyspnea-related-Chest Pain', 'Stroke-follow-Renal Insufficiency, Chronic', 'Stroke-occur-Renal Insufficiency, Chronic', 'Death-follow-Renal Insufficiency, Chronic', 'Renal Insufficiency, Chronic-control-Hypertension', 'Renal Insufficiency, Chronic-suffer-Stroke', 'Stroke-suffer-Death', 'Renal Insufficiency, Chronic-survive-Stroke', 'Respiratory Insufficiency-give-Death', 'Myelodysplastic Syndromes-acquired-Neoplasms', 'Myelodysplastic Syndromes-acquired-Leukemia, Myeloid, Acute', 'Bone Marrow Diseases-provide-Myelodysplastic Syndromes', 'Fatigue-last-Chemical and Drug Induced Liver Injury', 'Chemical and Drug Induced Liver Injury-last-Thrombocytopenia', 'Pancreatic Neoplasms-palliated-Biliary Dyskinesia', 'Chemical and Drug Induced Liver Injury-last-Jaundice', 'Chemical and Drug Induced Liver Injury-last-Drug-Related Side Effects and Adverse Reactions', 'Death-extend-Infections', 'Stroke-leave-Nervous System Diseases', 'Death-leave-Nervous System Diseases', 'Wounds and Injuries-associated-Brain Injuries', 'Brain Injuries-associated-Wounds and Injuries', 'Cerebral Infarction-occur-Arterial Occlusive Diseases', 'Lymphedema-predict-Breast Neoplasms', 'Neuronal Ceroid-Lipofuscinoses-characterised-Dementia', 'Neuronal Ceroid-Lipofuscinoses-characterised-Death', 'Neurodegenerative Diseases-characterised-Dementia', 'Neurodegenerative Diseases-characterised-Death', 'Asthma-arise-Lung Neoplasms', 'Death-increase-Diabetes Mellitus', 'Neurologic Manifestations-drive-Heart Arrest', 'Memory Disorders-associated-Muscle Rigidity', 'Muscle Rigidity-associated-Memory Disorders', 'Alzheimer Disease-associated-Muscle Rigidity', 'Muscle Rigidity-associated-Alzheimer Disease', 'Alzheimer Disease-associated-Tremor', 'Tremor-associated-Alzheimer Disease', 'Dyskinesia, Drug-Induced-associated-Muscle Rigidity', 'Muscle Rigidity-associated-Dyskinesia, Drug-Induced', 'Dyskinesia, Drug-Induced-associated-Tremor', 'Tremor-associated-Dyskinesia, Drug-Induced', 'Dyskinesia, Drug-Induced-associated-Parkinson Disease', 'Parkinson Disease-associated-Dyskinesia, Drug-Induced', 'Severe Acute Respiratory Syndrome-employed-Alzheimer Disease', 'HIV Infections-include-Kidney Diseases', 'Cardiovascular Diseases-implicated-Death, Sudden', 'Arrhythmias, Cardiac-implicated-Death, Sudden', 'Muscular Dystrophy, Duchenne-assess-Fractures, Bone', 'Muscular Dystrophy, Duchenne-assess-Osteoporosis', 'Muscular Dystrophy, Duchenne-improve-Fractures, Bone', 'Venous Thromboembolism-occur-Lymphoma', 'Muscular Dystrophy, Duchenne-mitigate-Osteoporosis', 'Cholestasis-progress-Liver Failure', 'Thrombosis-treat-Lymphoma', 'Pancreatitis-include-Gastrointestinal Diseases', 'Mitochondrial Diseases-associated-Huntington Disease', 'Huntington Disease-associated-Mitochondrial Diseases', 'Fibromyalgia-termed-Pain', 'Neoplasms, Cystic, Mucinous, and Serous-differ-Neoplasms', 'Deglutition Disorders-expose-Fistula', 'Osteoarthritis-rise-Obesity', 'Weight Loss-constitute-Osteoarthritis', 'Obesity-constitute-Osteoarthritis', 'Megalencephaly-include-Nervous System Diseases', 'Hydrocephalus-include-Nervous System Diseases', 'Cerebral Palsy-include-Nervous System Diseases', 'Dysautonomia, Familial-considered-Cardiomyopathy, Hypertrophic', 'Nervous System Malformations-include-Nervous System Diseases', 'Fabry Disease-result-Thoracic Outlet Syndrome', 'Dysautonomia, Familial-result-Thoracic Outlet Syndrome', 'Mastocytosis, Systemic-result-Thoracic Outlet Syndrome', 'Pulmonary Arterial Hypertension-associated-Heart Diseases', 'Heart Diseases-associated-Pulmonary Arterial Hypertension', 'Cyanosis-lead-Polycythemia', 'Ventricular Dysfunction-predict-Death', 'Heart Failure-comprise-Death', 'Communicable Diseases-comprise-Death', 'Death, Sudden, Cardiac-comprise-Death', 'Obesity-associated-Polycystic Ovary Syndrome', 'Polycystic Ovary Syndrome-associated-Obesity', 'Muscular Dystrophy, Duchenne-experience-Urinary Incontinence', 'Arthritis, Rheumatoid-include-Musculoskeletal Diseases', 'HIV Infections-change-Death', 'Lipodystrophy-contribute-Liver Failure', 'Lipodystrophy-contribute-Infections', 'Cardiovascular Diseases-contribute-Liver Failure', 'Cardiovascular Diseases-contribute-Infections', 'Neoplasms-demonstrate-Death', 'Lung Diseases-demonstrate-Death', 'Proteinuria-reported-Renal Insufficiency', 'Death-encountered-Lung Diseases', 'Heart Diseases-lead-Death', 'Weight Loss-become-Obesity', 'Pediatric Obesity-become-Obesity', 'Vision Disorders-compensate-Hearing Loss', 'Tuberculosis-adjunct-Hepatitis B, Chronic', 'Tuberculosis-adjunct-Communicable Diseases', 'Neurodegenerative Diseases-exhibit-Neurologic Manifestations', 'Neurodegenerative Diseases-exhibit-Death', 'Death-preceded-Muscle Weakness', 'Cystic Fibrosis-turn-Chronic Disease', 'Radiation Injuries-affected-Neoplasms', 'Lung Diseases-affected-Cystic Fibrosis', 'Death-affected-Cystic Fibrosis', 'Amyotrophic Lateral Sclerosis-make-Spinal Cord Diseases', 'Neoplasms-threatening-Infections', 'Drug-Related Side Effects and Adverse Reactions-threatening-Infections', 'Neoplasms-avoided-Infections', 'Hyperkinesis-sensitize-Prostatic Neoplasms', 'Anemia-occur-Renal Insufficiency, Chronic', 'Heart Failure-combined-Anemia', 'Cystic Fibrosis-report-Neoplasms', 'Neoplasms-increased-Colorectal Neoplasms', 'Neoplasms-increased-Pancreatic Neoplasms', 'Cystic Fibrosis-increased-Neoplasms', 'Cystic Fibrosis-increased-Colorectal Neoplasms', 'Neoplasms-increased-Cystic Fibrosis', 'Cystic Fibrosis-increased-Pancreatic Neoplasms', 'Aneurysm-lead-Blind Loop Syndrome', 'Aneurysm-lead-Malabsorption Syndromes', 'Aneurysm-lead-Malnutrition', 'Aneurysm-lead-Diarrhea', 'Aneurysm-lead-Constipation', 'Aneurysm-lead-Pneumatosis Cystoides Intestinalis', 'Fecal Incontinence-managed-Constipation', 'Femoral Neuropathy-lead-Pneumatosis Cystoides Intestinalis', 'Mastocytosis, Systemic-characterized-Fibrosis', 'Death-combined-Renal Insufficiency, Chronic', 'Rectal Diseases-screening-Malnutrition', 'Heart Failure-combined-Renal Insufficiency, Chronic', 'Fibrosis-lead-Pneumatosis Cystoides Intestinalis', 'Death-compare-Renal Insufficiency, Chronic', 'Autoimmune Diseases of the Nervous System-characterized-Inflammation', 'Stroke-compare-Breast Neoplasms', 'Coinfection-give-Infections', 'Cerebrovascular Disorders-treat-Intracranial Aneurysm', 'Cerebrovascular Disorders-treat-Aneurysm, Ruptured', 'Intracranial Aneurysm-treat-Aneurysm, Ruptured', 'Blood Coagulation Disorders-understand-Hemophilia B', 'Central Nervous System Diseases-include-Acquired Immunodeficiency Syndrome', 'Hemophilia B-address-Pain', 'Neuroendocrine Tumors-include-Acquired Immunodeficiency Syndrome', 'Neoplasms-include-Acquired Immunodeficiency Syndrome', 'Central Nervous System Diseases-include-Death', 'Neuroendocrine Tumors-include-Death', 'Blister-range-Heart Failure', 'Fractures, Bone-range-Heart Failure', 'Drug Hypersensitivity-linked-Asthma', 'Ovarian Diseases-yield-Breast Neoplasms', 'Fractures, Bone-related-Neoplasms', 'Muscle Hypotonia-accompanied-Hypogonadism', 'Hyperphagia-lead-Weight Gain', 'Neoplasms-affect-Ovarian Neoplasms', 'Ovarian Neoplasms-grow-Neoplasms', 'Ischemia-caused-Aneurysm', 'Disease-lead-Heart Failure', 'Multiple Sclerosis-use-Optic Neuritis', 'Optic Neuritis-associated-Multiple Sclerosis', 'Multiple Sclerosis-associated-Optic Neuritis', 'Optic Neuritis-reduce-Multiple Sclerosis', 'Bone Neoplasms-associated-Adrenal Insufficiency', 'Adrenal Insufficiency-associated-Bone Neoplasms', 'Foot Ulcer-associated-Death', 'Death-associated-Foot Ulcer', 'Somatosensory Disorders-result-Ischemia', 'Muscular Atrophy-result-Ischemia', 'Muscle Weakness-result-Ischemia', 'Lung Diseases, Obstructive-become-Death', 'Colorectal Neoplasms-compare-Neoplasms', 'Hemolysis-considered-Diabetes Mellitus', 'Diabetes Mellitus-considered-Hemolysis', 'Peripheral Arterial Disease-develop-Diabetes Mellitus', 'Pleural Effusion, Malignant-diagnose-Neoplasms', 'Fibroadenoma-detect-Fibrocystic Breast Disease', 'Fibroadenoma-detect-Neoplasms', 'Heart Failure-exposed-Cardiotoxicity', 'Myositis Ossificans-appear-Abnormalities, Drug-Induced', 'Myositis Ossificans-ossificans-Abnormalities, Drug-Induced', 'Ossification, Heterotopic-ossificans-Myositis Ossificans', 'Immunologic Deficiency Syndromes-required-Liposarcoma', 'Immunologic Deficiency Syndromes-induce-Liposarcoma', 'Leiomyosarcoma-form-Neoplasms', 'Hemophilia A-confronted-Cardiovascular Diseases', 'Cardiac Output, Low-experience-Fractures, Bone', 'Wounds and Injuries-experience-Fractures, Bone', 'Infections-contribute-Viremia', 'Neuronal Ceroid-Lipofuscinoses-cause-Neurodegenerative Diseases', 'Pericardial Effusion-develop-Neoplasms', 'Sarcoma, Kaposi-classified-Acquired Immunodeficiency Syndrome', 'Hodgkin Disease-classified-Acquired Immunodeficiency Syndrome', 'Neoplasms-classified-Acquired Immunodeficiency Syndrome', 'Neoplasms-play-Hepatitis B', 'Death-conducted-Hemophilia A', 'Arbovirus Infections-caused-Death', 'Mastocytosis, Systemic-associated-Neoplasms', 'Neoplasms-associated-Mastocytosis, Systemic', 'Neoplasms-integrated-Drug-Related Side Effects and Adverse Reactions', 'Adenocarcinoma-include-Death', 'Osteomyelitis-diagnosing-Diabetic Foot', 'Amyotrophic Lateral Sclerosis-lead-Paralysis', 'Neurodegenerative Diseases-lead-Paralysis', 'Pain-perceive-Infections', 'Coronary Artery Disease-develop-Angina Pectoris', 'Coronary Artery Disease-described-Drug Resistant Epilepsy', 'Death-increased-Hepatopulmonary Syndrome', 'Death-increased-Hypoxia', 'Hepatopulmonary Syndrome-increased-Hypoxia', 'Infertility, Female-cause-Primary Ovarian Insufficiency', 'Lymphatic Diseases-related-Lymphoma, Non-Hodgkin', 'Lymphatic Diseases-underlie-Lymphoma, Non-Hodgkin', 'Hepatopulmonary Syndrome-enhance-Hypoxia', 'Hepatopulmonary Syndrome-decrease-Death', 'Hypoxia-decrease-Death', 'Amyloidosis-characterized-Multiple Organ Failure', 'Amyloidosis-result-Multiple Organ Failure', 'Amyloidosis-characterized-Death', 'Amyloidosis-lead-Death', 'Dyspnea-define-Hepatopulmonary Syndrome', 'Malaria-offer-Death', 'Obesity-associated-Cardiac Complexes, Premature', 'Cardiac Complexes, Premature-associated-Obesity', 'Obesity-associated-Death, Sudden', 'Death, Sudden-associated-Obesity', 'Cardiovascular Diseases-documented-Obesity', 'Adenoma-include-Fibrous Dysplasia of Bone', 'Adenoma-include-Acromegaly', 'Leukemia, Myelogenous, Chronic, BCR-ABL Positive-discriminated-Bone Marrow Failure Disorders', 'Neoplasms-cause-Acromegaly', 'Acromegaly-control-Neoplasms', 'Neoplasms-encase-Carcinoma', 'Neoplasms-encase-Ascites', 'Short Bowel Syndrome-undergo-Intestinal Atresia', 'Short Bowel Syndrome-undergo-Neoplasms', 'Intestinal Atresia-undergo-Neoplasms', 'Meningeal Carcinomatosis-occur-Neoplasms', 'Headache-present-Neoplasm Metastasis', 'Nausea-present-Neoplasm Metastasis', 'Vomiting-present-Neoplasm Metastasis', 'Ataxia-present-Neoplasm Metastasis', 'Neoplasms-surpass-Cardiovascular Diseases', 'Cardiovascular Diseases-surpass-Death', 'Cardiac Output, Low-fall-Uterine Inertia', 'Death-increase-Hypertension, Renal', 'Death-occur-End Stage Liver Disease', 'Death-increase-Nephritis', 'Death-increase-Nephrotic Syndrome', 'Death-occur-Fibrosis', 'Death-increase-Nephrosis', 'Phenylketonurias-impacted-HIV Infections', 'Cardiovascular Diseases-reduce-Heart Diseases', 'Neoplasms-consider-Drug-Related Side Effects and Adverse Reactions', 'Critical Illness-defined-Pain', 'Critical Illness-defined-Ischemia', 'Anemia-estimate-Kidney Diseases', 'Hyperglycemia-overestimate-Kidney Failure, Chronic', 'Aneurysm-occur-Rupture', 'Aneurysm-occur-Death', 'Liver Diseases-induced-Hepatitis C', 'Neoplasms-compensated-Death', 'Death-compensated-Breast Neoplasms', 'Neoplasms-compensated-Breast Neoplasms', 'Cardiovascular Diseases-reduce-Stroke', 'Obesity-associated-Heart Arrest', 'Heart Arrest-associated-Obesity', 'Ovarian Neoplasms-show-Primary Ovarian Insufficiency', 'Malabsorption Syndromes-suggested-Weight Loss', 'Jaundice-related-Airway Obstruction', 'Jaundice-reoccur-Airway Obstruction', 'Chemical and Drug Induced Liver Injury-recognized-Hemophilia A', 'Kidney Diseases-noted-Death', 'Kidney Diseases-noted-Renal Insufficiency', 'Kidney Diseases-noted-Proteinuria', 'Kidney Diseases-noted-Hypertension, Malignant', 'Hypoprothrombinemias-predict-Fibrosis', 'Airway Obstruction-become-Aortic Valve Stenosis', 'Methemoglobinemia-enhance-Hypoxia', 'Methemoglobinemia-explain-Anemia', 'Methemoglobinemia-explain-Leukemia', 'Hypoxia-explain-Anemia', 'Hypoxia-explain-Leukemia', 'Brain Diseases-develop-Fibrosis', 'Prostatic Neoplasms-need-Respiratory Tract Infections', 'Prostatic Neoplasms-prevent-Nervous System Diseases', 'Prostatic Hyperplasia-indicate-Prostatic Neoplasms', 'Hypertension, Pulmonary-followed-Death', 'Hematologic Diseases-characterized-Neutropenia', 'Oral Ulcer-involve-Neutropenia', 'Sinusitis-involve-Neutropenia', 'Pneumonia-involve-Neutropenia', 'Peritoneal Neoplasms-involve-Neutropenia', 'Bacteremia-involve-Neutropenia', 'Neoplasm Metastasis-become-Neoplasms', 'Muscular Dystrophy, Duchenne-chairbound-Death', 'Arthritis-contribute-Death', 'Death-discussed-Arthritis', 'Melanoma-directed-Neoplasms', 'Drug-Related Side Effects and Adverse Reactions-given-Syphilis, Cardiovascular', 'Neoplasms-show-Glioblastoma', 'Glioma-affect-Neoplasms', 'Cystic Fibrosis-cause-Respiratory Tract Infections', 'Sarcoma-defined-Neoplasms', 'Kidney Diseases-associated-Albuminuria', 'Albuminuria-associated-Kidney Diseases', 'Hypertension-reduce-Alzheimer Disease', 'Renal Insufficiency, Chronic-diagnosed-Obesity', 'Carcinoma, Non-Small-Cell Lung-complicated-Neoplasm Metastasis', 'Metabolic Diseases-associated-Dyslipidemias', 'Dyslipidemias-associated-Metabolic Diseases', 'Metabolic Diseases-associated-Hyperglycemia', 'Hyperglycemia-associated-Metabolic Diseases', 'Neutropenia-diagnosed-Hematologic Neoplasms', 'Mycoses-diagnosed-Hematologic Neoplasms', 'Hematologic Neoplasms-diagnosed-Neutropenia', 'Obesity-establish-Inflammation', 'Parkinson Disease-cause-Movement Disorders', 'Mitochondrial Diseases-provide-Parkinson Disease', 'Neurodegenerative Diseases-cause-Movement Disorders', 'Neurologic Manifestations-include-Nervous System Diseases', 'Death-continue-Critical Illness', 'Leigh Disease-characterized-Neurodegenerative Diseases', 'Leigh Disease-characterized-Death', 'Mitochondrial Diseases-characterized-Neurodegenerative Diseases', 'Mitochondrial Diseases-characterized-Death', 'Dyspnea-modulate-Gliosis', 'Lung Diseases-differentiate-Pneumonia', 'Lung Diseases-differentiate-Tuberculosis', 'Cardiovascular Diseases-pose-Ischemia', 'Death-affect-Breast Neoplasms', 'Dementia-occur-HIV Infections', 'Sarcopenia-play-Death', 'Pelvic Neoplasms-managed-Pain', 'Inflammation-investigate-Nervous System Diseases', 'Malaria-limited-Hemolysis', 'Ehlers-Danlos Syndrome-develop-Intraabdominal Infections', 'Dystonia-base-Death', 'Dystonia-determine-Death', 'Heart Diseases-subjected-Myocardial Infarction', 'Genetic Diseases, Inborn-turn-Neoplasms', 'Neoplasms-turn-Cardiovascular Diseases', 'Neoplasms-induce-Cardiovascular Abnormalities', 'Death-given-Neoplasms', 'Death-given-Prostatic Neoplasms', 'Infections-associated-Parkinson Disease', 'Parkinson Disease-associated-Infections', 'Anemia-provide-Neoplasms', 'Anemia-interrogate-Drug-Related Side Effects and Adverse Reactions', 'Atherosclerosis-contribute-Coronary Artery Disease', 'Opportunistic Infections-contribute-Coronary Artery Disease', 'Blood Coagulation Disorders-contribute-Coronary Artery Disease', 'Acquired Immunodeficiency Syndrome-reduce-Death', 'Acquired Immunodeficiency Syndrome-reduce-Diabetes Mellitus', 'Acquired Immunodeficiency Syndrome-reduce-Hypercholesterolemia', 'Death-reduce-Hypercholesterolemia', 'HIV Infections-provided-Acquired Immunodeficiency Syndrome', 'Temporomandibular Joint Disorders-reported-Bruxism', 'Death-affected-Communicable Diseases', 'Neoplasms-associate-Intestinal Diseases', 'Intestinal Diseases-associate-Neoplasms', 'Death-group-Malocclusion', 'Death-identified-Ischemia', 'Death-combined-Heart Diseases', 'Death-occur-Acute Kidney Injury', 'Neoplasms-combined-Heart Diseases', 'Death-occur-Myocarditis', 'Hepatitis C-associate-Carcinoma, Hepatocellular', 'Carcinoma, Hepatocellular-associate-Hepatitis C', 'Calcinosis-treat-Heart Diseases', 'Pulmonary Valve Insufficiency-relieve-Airway Obstruction', 'Pulmonary Valve Insufficiency-relieve-Fractures, Bone', 'Death-occur-Neutropenia', 'Pulmonary Valve Insufficiency-prolong-Wounds and Injuries', 'Death-occur-Dehydration', 'Spinal Cord Injuries-impact-Tooth, Impacted', 'Infections-include-Multiple Organ Failure', 'Fatigue-associate-Signs and Symptoms, Respiratory', 'Signs and Symptoms, Respiratory-associate-Fatigue', 'Arteriovenous Malformations-result-Telangiectasia, Hereditary Hemorrhagic', 'Arteriovenous Malformations-oppose-Telangiectasia, Hereditary Hemorrhagic', 'Acquired Immunodeficiency Syndrome-live-Cardiovascular Diseases', 'Amyotrophic Lateral Sclerosis-involve-Nerve Degeneration', 'Amyotrophic Lateral Sclerosis-considered-Alcoholic Neuropathy', 'Amyotrophic Lateral Sclerosis-considered-Demyelinating Diseases', 'Amyotrophic Lateral Sclerosis-considered-Death', 'Death-associate-Multiple Sclerosis', 'Multiple Sclerosis-associate-Death', 'Death-examine-Amyotrophic Lateral Sclerosis', 'Amyotrophic Lateral Sclerosis-associate-Multiple Sclerosis', 'Multiple Sclerosis-associate-Amyotrophic Lateral Sclerosis', 'Nerve Degeneration-delay-Amyotrophic Lateral Sclerosis', 'Pulmonary Disease, Chronic Obstructive-exposed-Hypertension, Pulmonary', 'Amyotrophic Lateral Sclerosis-delay-Death', 'Lung Diseases-exposed-Hypertension, Pulmonary', 'Idiopathic Pulmonary Fibrosis-exposed-Hypertension, Pulmonary', 'Hypertension, Pulmonary-fall-Lung Diseases', 'Sleep Wake Disorders-exposed-Hypertension, Pulmonary', 'Hypertension, Pulmonary-fall-Hypoxia', 'Polycystic Ovary Syndrome-associated-Weight Gain', 'Weight Gain-associated-Polycystic Ovary Syndrome', 'Neoplasms-known-Chordoma', 'Neoplasms-exist-Chordoma', 'Chordoma-maintain-Neoplasms', 'Atherosclerosis-assumed-Lupus Erythematosus, Systemic', 'Atherosclerosis-assumed-Cardiovascular Diseases', 'Cardiovascular Diseases-prevail-Coronary Artery Disease', 'Cardiovascular Diseases-prevail-Peripheral Vascular Diseases', 'Lupus Erythematosus, Systemic-described-Cardiovascular Diseases', 'Cardiovascular Diseases-described-Nephritis', 'Adenomatous Polyposis Coli-suppress-Neoplasms', 'Arterio-Arterial Fistula-suggested-Anemia, Sickle Cell', 'Anemia, Sickle Cell-undergo-Arterio-Arterial Fistula', 'Anemia, Sickle Cell-considered-Arterio-Arterial Fistula', 'Cushing Syndrome-cured-Death', 'Hyperlipidemias-defined-Lipodystrophy', 'Diabetes Mellitus-defined-Lipodystrophy', 'Fatigue-provide-Glioma', 'Seizures-cause-Neoplasms', 'Neoplasms-associate-Sclerosis', 'Sclerosis-associate-Neoplasms', 'Bone Marrow Failure Disorders-transform-Leukemia', 'Alzheimer Disease-characterized-Psychoses, Substance-Induced', 'Death-reduce-Immunologic Deficiency Syndromes', 'Pneumonia-reduce-Crohn Disease', 'Myopia-found-Anophthalmos', 'Infections-play-Cystic Fibrosis', 'Neoplasm Metastasis-vary-Neoplasms', 'Drug-Related Side Effects and Adverse Reactions-given-Neoplasm Metastasis', 'Nervous System Diseases-define-Neurodegenerative Diseases', 'Neoplasms-delay-Weight Loss', 'Alzheimer Disease-consist-Psychoses, Substance-Induced', 'Lymphoma-remain-Cardiotoxicity', 'Oculocerebrorenal Syndrome-cause-Skin Neoplasms', 'Death-cause-Crohn Disease', 'Pre-Eclampsia-associated-Hypertension', 'Hypertension-associated-Pre-Eclampsia', 'Pre-Eclampsia-associated-Stroke', 'Stroke-associated-Pre-Eclampsia', 'Pre-Eclampsia-associated-Kidney Diseases', 'Kidney Diseases-associated-Pre-Eclampsia', 'Femoral Fractures-linked-Osteoporosis', 'Fractures, Compression-prevent-Osteoporosis', 'Cardiomyopathies-elicited-Inflammation', 'Cardiomyopathies-result-Heart Failure, Diastolic', 'Inflammation-result-Heart Failure, Diastolic', 'Diabetes Mellitus-mitigate-Cardiomyopathies', 'Diabetic Cardiomyopathies-mitigate-Cardiomyopathies', 'Heart Failure-mitigate-Cardiomyopathies', 'Critical Illness-address-Aneurysm', 'Wounds and Injuries-used-Low Back Pain', 'Ankle Injuries-used-Low Back Pain', 'Inflammation-characterized-Vascular Remodeling', 'Muscular Atrophy, Spinal-characterized-Nerve Degeneration', 'Fibrosarcoma-include-Neoplasms', 'Hypertension-correct-Liver Diseases', 'Infections-treat-Drug Hypersensitivity', 'Hypothermia-trigger-Myotonia', 'Staphylococcal Infections-decrease-Cystic Fibrosis', 'Neoplasms-increase-Hemorrhage', 'Venous Thromboembolism-increase-Hemorrhage', 'Epilepsies, Partial-experience-Seizures', 'Epilepsy-issue-Drug Resistant Epilepsy', 'Psychoses, Substance-Induced-increase-Parkinson Disease', 'Dementia-increase-Parkinson Disease', 'Dystonia-suggest-Hypothalamic Neoplasms', 'Infections-perform-Pneumoperitoneum', 'Seizures-reduce-Psychomotor Disorders', 'Astrocytoma-understand-Neoplasms', 'Epilepsy-control-Seizures', 'Death-offset-Thromboembolism', 'Death-experience-Thromboembolism', 'Acromegaly-related-Pituitary Neoplasms', 'Dwarfism, Pituitary-promote-Atherosclerosis', 'Sleep Apnea Syndromes-used-Acromegaly', 'Sleep Apnea Syndromes-determine-Acromegaly', 'Lung Neoplasms-observed-Death', 'Obesity-stay-Weight Loss', 'Death-altered-Obesity', 'Neoplasms-identify-Multiple Pulmonary Nodules', 'Ulcer-followed-Diabetic Foot', 'Ulcer-followed-Infections', 'Breast Neoplasms-cause-Pain', 'Neuralgia-follow-Neoplasms', 'Pain-follow-Neoplasms', 'Genetic Diseases, Inborn-diagnosed-Death', 'Genetic Diseases, Inborn-diagnosed-Neoplasms', 'Nervous System Malformations-evidence-Neurodegenerative Diseases', 'Pituitary Neoplasms-associated-Death', 'Death-associated-Pituitary Neoplasms', 'Hypertension, Pulmonary-receive-Osteoporosis', 'Death-screen-Neoplasms', 'Bone Marrow Diseases-prevent-Hemorrhage', 'Bone Marrow Diseases-prevent-Infections', 'Death-suggest-Neoplasms', 'Urinary Bladder Neoplasms-queried-Neoplasms', 'Myoclonic Epilepsies, Progressive-associated-Kidney Diseases', 'Kidney Diseases-associated-Myoclonic Epilepsies, Progressive', 'Epilepsies, Myoclonic-associated-Kidney Diseases', 'Kidney Diseases-associated-Epilepsies, Myoclonic', 'Proteinuria-progress-Renal Insufficiency', 'Renal Insufficiency-progress-Proteinuria', 'Neoplasm Metastasis-suffer-Death', 'Fractures, Bone-occur-Hip Fractures', 'Hip Fractures-include-Musculoskeletal Diseases', 'Death-involve-Neoplasms', 'Death-involve-Liver Cirrhosis, Alcoholic', 'Respiratory Tract Diseases-involve-Neoplasms', 'Respiratory Tract Diseases-involve-Liver Cirrhosis, Alcoholic', 'Death-cause-Respiratory Tract Diseases', 'Aneurysm-involve-Neoplasms', 'Aneurysm-involve-Liver Cirrhosis, Alcoholic', 'Neoplasms-involve-Liver Cirrhosis, Alcoholic', 'Arteriovenous Fistula-reduce-Infections', 'Tuberculosis-correspond-Infections', 'Death-enter-Heart Arrest', 'von Hippel-Lindau Disease-associated-Hemangioma, Cavernous, Central Nervous System', 'Hemangioma, Cavernous, Central Nervous System-associated-von Hippel-Lindau Disease', 'von Hippel-Lindau Disease-associated-Kidney Diseases', 'Kidney Diseases-associated-von Hippel-Lindau Disease', 'von Hippel-Lindau Disease-associated-Pancreatic Cyst', 'Pancreatic Cyst-associated-von Hippel-Lindau Disease', 'von Hippel-Lindau Disease-associated-Adenoma', 'Adenoma-associated-von Hippel-Lindau Disease', 'von Hippel-Lindau Disease-associated-Pheochromocytoma', 'Pheochromocytoma-associated-von Hippel-Lindau Disease', 'von Hippel-Lindau Disease-associated-Endometrial Stromal Tumors', 'Endometrial Stromal Tumors-associated-von Hippel-Lindau Disease', 'von Hippel-Lindau Disease-associated-Cystadenoma', 'Cystadenoma-associated-von Hippel-Lindau Disease', 'Death-cause-Adenomatous Polyposis Coli', 'Colorectal Neoplasms-account-Death', 'Breast Neoplasms-predominate-Coronary Artery Disease', 'Death-predominate-Coronary Artery Disease', 'Death-reach-Leukemia, Lymphocytic, Chronic, B-Cell', 'Lymphoma-compare-Leukemia, Lymphocytic, Chronic, B-Cell', 'Neoplasms-compare-Leukemia, Lymphocytic, Chronic, B-Cell', 'Death-impact-Shock, Septic', 'Shock, Septic-related-Shock', 'Shock, Septic-reflect-Shock', 'Shock, Septic-related-Multiple Organ Failure', 'Shock, Septic-reflect-Multiple Organ Failure', 'Kidney Diseases-developed-Diabetes Mellitus', 'Retinal Diseases-developed-Diabetes Mellitus', 'Nervous System Diseases-developed-Diabetes Mellitus', 'Hypoglycemia-developed-Diabetes Mellitus', 'Communicable Diseases-developed-Diabetes Mellitus', 'IgA Vasculitis-contribute-Death', 'Death-prevented-Hypertension', 'Coronary Artery Disease-prevented-Hypertension', 'Brain Injuries-Lost-Death', 'Migraine Disorders-impose-Headache', 'Urologic Neoplasms-perform-Cutaneous Fistula', 'Kidney Diseases-perform-Cutaneous Fistula', 'Cutaneous Fistula-perform-Prostatic Neoplasms', 'Cutaneous Fistula-perform-Urinary Bladder Neoplasms', 'Cutaneous Fistula-perform-Neoplasms', 'Echinococcosis-avoid-Rupture', 'Death-found-Giant Cell Arteritis', 'Fibrosis-battle-Liver Cirrhosis', 'Death-use-Cardiovascular Diseases', 'Inflammatory Bowel Diseases-mount-Inflammation', 'Liver Diseases, Alcoholic-associated-Adrenoleukodystrophy', 'Adrenoleukodystrophy-associated-Liver Diseases, Alcoholic', 'Thrombocytopenia-remain-Death', 'Glucose Metabolism Disorders-reduce-Fatty Liver', 'Glucose Metabolism Disorders-reduce-Obesity', 'Drug-Related Side Effects and Adverse Reactions-affect-Seizures', 'Sleep Wake Disorders-targeted-Memory Disorders', 'Neoplasms-entail-Respiratory Distress Syndrome', 'Glaucoma-include-Nerve Degeneration', 'Glaucoma-prevent-Nerve Degeneration', 'Sleep Wake Disorders-combine-Diabetes Mellitus', 'Nervous System Diseases-characterized-Epilepsy, Benign Neonatal', 'Obesity-result-Brain Diseases', 'Metabolic Syndrome-result-Brain Diseases', 'Death-reported-Alzheimer Disease', 'Pulmonary Arterial Hypertension-associated-Heart Defects, Congenital', 'Heart Defects, Congenital-associated-Pulmonary Arterial Hypertension', 'Acute Kidney Injury-lead-Primary Graft Dysfunction', 'Hemolysis-associated-Thrombocytopenia', 'Thrombocytopenia-associated-Hemolysis', 'Hemolysis-associated-Spinal Cord Injuries', 'Spinal Cord Injuries-associated-Hemolysis', 'Leukemia, Myelomonocytic, Juvenile-present-Gilbert Disease', 'Coronary Artery Disease-show-Coronary Stenosis', 'Stomach Neoplasms-reserve-Hemorrhage', 'Hemoptysis-develop-Lung Diseases', 'Pneumothorax-develop-Lung Diseases', 'Hypertension, Pulmonary-develop-Lung Diseases', 'Respiratory Insufficiency-develop-Lung Diseases', 'Cystic Fibrosis-develop-Inflammation', 'Cystic Fibrosis-develop-Infections', 'Death-tested-Prostatic Neoplasms', 'Intestinal Obstruction-related-Cystic Fibrosis', 'Inflammatory Bowel Diseases-related-Cystic Fibrosis', 'Heart Failure-associated-HIV Infections', 'HIV Infections-associated-Heart Failure', 'Ventricular Dysfunction-replaced-Cardiomyopathies', 'Cardiomyopathies-replaced-Ischemia', 'Ventricular Dysfunction-replaced-Ischemia', 'Sarcoidosis-associate-Hypertension, Pulmonary', 'Hypertension, Pulmonary-associate-Sarcoidosis', 'Hypertension, Pulmonary-observed-Sarcoidosis', 'Rhinitis, Allergic-induce-Fallopian Tube Diseases', 'Drug Hypersensitivity-induce-Fallopian Tube Diseases', 'Breast Neoplasms-experience-Drug-Related Side Effects and Adverse Reactions', 'HIV Infections-experience-Drug-Related Side Effects and Adverse Reactions', 'HIV Infections-act-Breast Neoplasms', 'Musculoskeletal Diseases-affect-Joint Diseases', 'Cardiomyopathy, Hypertrophic-associated-Myocardial Infarction', 'Myocardial Infarction-associated-Cardiomyopathy, Hypertrophic', 'Cardiomyopathy, Hypertrophic-associated-Stroke', 'Stroke-associated-Cardiomyopathy, Hypertrophic', 'Cardiomyopathy, Hypertrophic-associated-Hemorrhage', 'Hemorrhage-associated-Cardiomyopathy, Hypertrophic', 'Myeloproliferative Disorders-develop-Neoplasms', 'Myeloproliferative Disorders-lead-Lymphoma, B-Cell', 'Leukemia, Lymphoid-transform-Lymphoma, B-Cell', 'Death-become-Lupus Erythematosus, Systemic', 'Cardiovascular Diseases-become-Lupus Erythematosus, Systemic', 'Fatigue-suffered-Lupus Erythematosus, Systemic', 'Pain-exclude-Fatigue', 'Neoplasms-cause-Cardiovascular Diseases', 'Pain-exclude-Anemia', 'Werner Syndrome-include-Cataract', 'HIV Infections-estimated-Acquired Immunodeficiency Syndrome', 'HIV Infections-estimated-Nervous System Diseases', 'HIV Infections-suppress-Nervous System Diseases', 'Myelodysplastic Syndromes-used-Thalassemia', 'Hypertension-highlight-Neurodegenerative Diseases', 'Osteoporosis-affect-Bone Diseases, Metabolic', 'Osteoporosis-investigate-Fractures, Bone', 'Osteoporosis-treated-Fractures, Bone', 'Lung Neoplasms-diagnosed-Sarcoma', 'Sarcoma-diagnosed-Neoplasms', 'Sarcoma-diagnosed-Lung Neoplasms', 'Neoplasm Metastasis-attributed-Obesity', 'Heart Diseases-associated-Chromosome Aberrations', 'Chromosome Aberrations-associated-Heart Diseases', 'Acute Kidney Injury-evaluate-Hemorrhage', 'Hypoxia-related-Carcinoma, Squamous Cell', 'Neoplasms-related-Carcinoma, Squamous Cell', 'Airway Obstruction-include-Carcinoma, Squamous Cell', 'Airway Obstruction-include-Adenocarcinoma', 'Airway Obstruction-include-Carcinoma, Small Cell', 'Airway Obstruction-include-Carcinoma', 'Airway Obstruction-include-Neoplasms', 'Osteoporosis-affected-Fractures, Bone', 'Leukemia, Lymphocytic, Chronic, B-Cell-achieve-Drug-Related Side Effects and Adverse Reactions', 'Aneurysm-revolutionize-Aortic Aneurysm, Abdominal', 'Coronary Artery Disease-increase-Cardiovascular Diseases', 'Kidney Diseases-include-Hypertrophy', 'Kidney Diseases-include-Acute Kidney Injury', 'Kidney Diseases-include-Denys-Drash Syndrome', 'Kidney Diseases-include-Hematuria', 'Carcinoma, Medullary-include-Kidney Diseases', 'Anemia, Sickle Cell-cause-Kidney Diseases', 'Kidney Diseases-include-Infections', 'Kidney Diseases-contribute-Anemia, Sickle Cell', 'Kidney Diseases-account-Death', 'Hepatitis C, Chronic-coinfected-HIV Infections', 'Stroke-implicated-Carotid Stenosis', 'Death-implicated-Carotid Stenosis', 'Carotid Stenosis-implicated-Stroke', 'HIV Infections-eradicate-Hepatitis C', 'Death-receive-HIV Infections', 'Death-receive-Hepatitis C', 'Liver Diseases-receive-HIV Infections', 'Liver Diseases-receive-Hepatitis C', 'Fatigue-evaluated-Breast Neoplasms', 'Carotid Stenosis-demonstrate-Hypotension', 'Hepatitis C-coinfected-HIV Infections', 'Atherosclerosis-induce-Inflammation', 'Glioma-include-Brain Neoplasms', 'Metabolic Syndrome-including-Death', 'Neurodegenerative Diseases-referred-Tauopathies', 'Neurodegenerative Diseases-include-Pick Disease of the Brain', 'Neurodegenerative Diseases-include-Retinal Degeneration', 'Tauopathies-referred-Alzheimer Disease', 'Tauopathies-referred-Pick Disease of the Brain', 'Tauopathies-referred-Supranuclear Palsy, Progressive', 'Chemical and Drug Induced Liver Injury-defined-Fatty Liver', 'Chemical and Drug Induced Liver Injury-progress-Fibrosis', 'Inflammation-defined-Fatty Liver', 'Fatty Liver-progress-Fibrosis', 'Fatty Liver-defined-Fibrosis', 'Metabolic Syndrome-associated-Fibrosis', 'Fibrosis-associated-Metabolic Syndrome', 'Metabolic Syndrome-pose-Carcinoma, Hepatocellular', 'Metabolic Syndrome-pose-Fibrosis', 'Hemophilia A-experience-Wounds and Injuries', 'Hemophilia A-experience-Hemorrhage', 'Wounds and Injuries-experience-Hemorrhage', 'Infections-cause-Chemical and Drug Induced Liver Injury', 'Hemorrhage-prevent-Hemophilia A', 'Infections-lead-Blood Coagulation Disorders', 'Chemical and Drug Induced Liver Injury-lead-Blood Coagulation Disorders', 'Glucose Intolerance-cause-Death', 'Cerebrovascular Disorders-cause-Aneurysm', 'Chromosome Aberrations-defined-Metabolic Diseases', 'Neoplasms-minimize-Hearing Loss', 'HIV Infections-remain-Coinfection', 'Neoplasms-minimize-Facial Paralysis', 'HIV Infections-remain-Hepatitis B', 'HIV Infections-associated-Liver Diseases', 'Liver Diseases-associated-HIV Infections', 'Coinfection-remain-Death', 'HIV Infections-underlie-Coinfection', 'Chemical and Drug Induced Liver Injury-underlie-Coinfection', 'Metabolic Diseases-underlie-Coinfection', 'Liver Cirrhosis-underlie-Coinfection', 'HIV Infections-accompanied-Liver Diseases', 'HIV Infections-accompanied-Carcinoma, Hepatocellular', 'Neoplasms-consist-Lymphoma', 'Diabetes Mellitus-fell-Death', 'Hypertension-fell-Death', 'Myocardial Infarction-fell-Death', 'Death-predict-Mesothelioma', 'Hepatomegaly-hint-Lysosomal Storage Diseases', 'Death-rescue-Weight Loss', 'Muscular Atrophy, Spinal-lead-Death', 'Fabry Disease-cause-Pain', 'Lysosomal Storage Diseases-cause-Pain', 'Diabetes Mellitus, Type 2-live-Diabetes Mellitus', 'Diabetes Mellitus, Type 2-encourage-Diabetes Mellitus', 'Coronary Artery Disease-become-Neoplasms', 'Hyperoxaluria-associated-Hepatic Insufficiency', 'Hepatic Insufficiency-associated-Hyperoxaluria', 'Obesity-use-Death', 'Obesity-contribute-Gastroesophageal Reflux', 'Obesity-contribute-Gallstones', 'Obesity, Abdominal-typify-Metabolic Syndrome', 'Neoplasm Metastasis-achieve-Drug-Related Side Effects and Adverse Reactions', 'Atherosclerosis-associated-Hypotension', 'Hypotension-associated-Atherosclerosis', 'Acquired Immunodeficiency Syndrome-associated-Hypotension', 'Hypotension-associated-Acquired Immunodeficiency Syndrome', 'Coronary Artery Disease-apply-Death', 'Coronary Artery Disease-gained-Cardiovascular Diseases', 'Urinary Incontinence-perceived-Urinary Incontinence, Stress', 'Hypoxia-lead-Hypertrophy', 'Anemia, Sickle Cell-manage-Pain', 'Obesity, Abdominal-considered-Lipoma', 'HIV Infections-evolve-Tuberculosis', 'Fibrosis-use-Liver Diseases', 'Colorectal Neoplasms-prevent-Obesity', 'Obesity-associated-Colorectal Neoplasms', 'Colorectal Neoplasms-associated-Obesity', 'Radiation Pneumonitis-experience-Drug-Related Side Effects and Adverse Reactions', 'Nausea-experience-Drug-Related Side Effects and Adverse Reactions', 'Gastrointestinal Hemorrhage-experience-Drug-Related Side Effects and Adverse Reactions', 'Prostatic Neoplasms-wish-Neoplasms', 'Carcinoma, Hepatocellular-control-Neoplasms', 'Neurodegenerative Diseases-marked-Atrophy', 'Neoplasms-find-Chronic Disease', 'Genetic Diseases, Inborn-complicated-Acute Disease', 'Marfan Syndrome-include-Genetic Diseases, Inborn', 'Acromegaly-reverse-Death', 'Anemia-develop-Kidney Diseases', 'Death-screen-Peripheral Arterial Disease', 'Infections-develop-Leukemia-Lymphoma, Adult T-Cell', 'Agranulocytosis-translate-Neutropenia', 'Agranulocytosis-translate-Sepsis', 'Death-ascertained-Tooth Eruption, Ectopic', 'Ventricular Septal Rupture-include-Cardiovascular Abnormalities', 'Pulmonary Valve Stenosis-include-Cardiovascular Abnormalities', 'Pulmonary Atresia-include-Cardiovascular Abnormalities', 'Tricuspid Valve Stenosis-include-Cardiovascular Abnormalities', 'Corneal Opacity-result-Arbovirus Infections', 'Corneal Opacity-result-Malaria', 'Corneal Opacity-result-Onchocerciasis', 'Prostatic Neoplasms-expressed-Neoplasms', 'Fibrosis-occur-Primary Myelofibrosis', 'Myotonic Dystrophy-contribute-Erectile Dysfunction', 'Acidosis-relieve-Anorexia', 'Acidosis-relieve-Hemolytic-Uremic Syndrome', 'Anorexia-relieve-Hemolytic-Uremic Syndrome', 'Arrhythmias, Cardiac-identify-Death', 'Death-include-Arrhythmias, Cardiac', 'Quadriplegia-readmitted-Spinal Injuries', 'Death-include-Cardiomyopathy, Hypertrophic', 'Cerebrovascular Disorders-show-Death', 'Hematuria-undergo-Carcinoma, Squamous Cell', 'Neoplasms, Multiple Primary-perform-Neoplasms', 'Prostatic Neoplasms-differentiated-Neoplasms', 'Motor Neuron Disease-show-Pain', 'Prostatic Neoplasms-influenced-Death', 'Prostatic Neoplasms-change-Death', 'Signs and Symptoms, Respiratory-dominate-Death', 'Diarrhea-dominate-Death', 'Fever-dominate-Death', 'Jaundice-dominate-Death', 'Infertility, Female-include-Infections', 'Acute Kidney Injury-complicated-Brain Edema', 'Inflammatory Bowel Diseases-implicated-Thrombosis', 'Thromboembolism-implicated-Thrombosis', 'Intracranial Arteriovenous Malformations-reviewed-Seizures', 'Thrombosis-implicated-Crohn Disease', 'Carcinoid Tumor-related-Neoplasms', 'Carcinoid Tumor-secreted-Neoplasms', 'Renal Insufficiency-predict-Diabetes Mellitus, Type 1', 'Diabetes Mellitus-screened-Cardiovascular Diseases', 'Pneumonia, Pneumocystis-foreshadow-Immunologic Deficiency Syndromes', 'Pneumonia, Pneumocystis-foreshadow-Death', 'Opportunistic Infections-foreshadow-Immunologic Deficiency Syndromes', 'Opportunistic Infections-foreshadow-Death', 'Immunologic Deficiency Syndromes-foreshadow-Death', 'Infections-foreshadow-Immunologic Deficiency Syndromes', 'Infections-foreshadow-Death', 'Death-include-Rectal Diseases', 'Neoplasms-studied-Multiple Myeloma', 'Rectal Diseases-include-Urinary Incontinence', 'Acquired Immunodeficiency Syndrome-attributed-Quadriplegia', 'Osteoporosis-increase-Endometrial Neoplasms', 'Acquired Immunodeficiency Syndrome-presented-Sarcoma, Kaposi', 'Leukemia, Lymphoid-bring-Thrombocytopenia', 'Leukemia, Hairy Cell-bring-Thrombocytopenia', 'Lymphoma-bring-Thrombocytopenia', 'Aortic Aneurysm, Abdominal-prevent-Rupture', 'Rupture-prevent-Death', 'Coronary Artery Disease-deprive-Aneurysm', 'Death-deprive-Aneurysm', 'Embolism, Cholesterol-complicated-Pain', 'Cystinosis-exhibit-Growth Disorders', 'Cardiomyopathies-increase-Atherosclerosis', 'Myocardial Infarction-occur-Ischemia', 'Myocardial Infarction-occur-Necrosis', 'Myocardial Infarction-occur-Heart Septal Defects, Ventricular', 'Death-compare-Metabolic Diseases', 'Atherosclerosis-contribute-Hypertension', 'Infections-predispose-Thrombosis', 'Neoplasms-develop-Primary Ovarian Insufficiency', 'Death-increase-Substance-Related Disorders', 'Neoplasms-explore-Melanoma', 'Metabolic Syndrome-increase-Psychomotor Disorders', 'Sarcoidosis-include-Pulmonary Fibrosis', 'Granuloma-serve-Fibrosis', 'Cardiotoxicity-induced-Death', 'Cardiotoxicity-classify-Death', 'Cardiotoxicity-compare-Neoplasms', 'Sarcoidosis-translated-Lung Diseases', 'Primary Graft Dysfunction-account-Death', 'Drug-Related Side Effects and Adverse Reactions-surface-Death', 'Drug-Related Side Effects and Adverse Reactions-surface-Neoplasms', 'Cardiovascular Diseases-include-Arrhythmias, Cardiac', 'Cardiovascular Diseases-include-Long QT Syndrome', 'Cardiovascular Diseases-include-Infarction', 'Cardiovascular Diseases-include-Ventricular Dysfunction', 'Cardiovascular Diseases-include-Heart Failure', 'Cardiovascular Diseases-include-Thromboembolism', 'Heart Valve Diseases-transform-Death', 'Neoplasms-become-Cardiotoxicity', 'Obesity-lead-Malnutrition', 'Malnutrition-play-Obesity', 'Death-play-Obesity', 'Aneurysm-associated-Craniocerebral Trauma', 'Craniocerebral Trauma-associated-Aneurysm', 'Aneurysm-associated-Anemia', 'Anemia-associated-Aneurysm', 'Aneurysm-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-Aneurysm', 'Aneurysm-associated-Autoimmune Diseases', 'Autoimmune Diseases-associated-Aneurysm', 'Aneurysm-associated-Immunologic Deficiency Syndromes', 'Immunologic Deficiency Syndromes-associated-Aneurysm', 'Epilepsy-present-Seizures', 'Pain-used-Cardiovascular Diseases', 'Pain-used-Stroke', 'Opioid-Related Disorders-identify-Drug Overdose', 'Atrial Fibrillation-document-Heart Valve Diseases', 'Atrial Fibrillation-document-Mitral Valve Stenosis', 'Heart Valve Diseases-thought-Thromboembolism', 'Atrial Fibrillation-thought-Thromboembolism', 'Endocarditis-referred-Aneurysm', 'Endocarditis-referred-Pain', 'Dyspnea-allude-Heart Failure', 'Fatigue-allude-Heart Failure', 'Inflammation-play-Psoriasis', 'Edema-allude-Heart Failure', 'Neoplasms-modified-Infections', 'Diabetic Foot-affect-Death', 'Anemia, Sickle Cell-associated-Pain', 'Pain-associated-Anemia, Sickle Cell', 'Neuromuscular Diseases-characterized-Muscle Weakness', 'Hemolysis-associated-Pain', 'Pain-associated-Hemolysis', 'Heart Diseases-exposed-Obesity', 'Heart Diseases-exposed-Cardiovascular Diseases', 'Metabolic Diseases-progress-Cardiovascular Diseases', 'Hyperlipidemias-result-Death', 'Obesity-result-Death', 'Thromboembolism-associate-Heart Failure', 'Heart Failure-associate-Thromboembolism', 'Death-remain-Myotonic Dystrophy', 'Sleep Initiation and Maintenance Disorders-achieve-Neoplasms', 'Pain-evaluated-Musculoskeletal Diseases', 'Drug-Related Side Effects and Adverse Reactions-reveal-Neuroblastoma', 'Constriction, Pathologic-caused-Cholangiocarcinoma', 'Heart Diseases-decrease-Death', 'Mitochondrial Diseases-induce-Drug-Related Side Effects and Adverse Reactions', 'Mitochondrial Diseases-induce-Muscular Diseases', 'Mitochondrial Diseases-induce-Kidney Diseases', 'Muscular Diseases-contribute-Drug-Related Side Effects and Adverse Reactions', 'Mitochondrial Diseases-initiate-Cardiovascular Diseases', 'Hyperglycemia-guide-Diabetes Mellitus', 'Spastic Paraplegia, Hereditary-refer-Neurodegenerative Diseases', 'Spastic Paraplegia, Hereditary-represent-Muscle Spasticity', 'Spastic Paraplegia, Hereditary-represent-Muscle Weakness', 'Stomach Diseases-remain-Stomach Neoplasms', 'Breast Neoplasms-mean-Prostatic Neoplasms', 'Cardiovascular Diseases-gained-Myocardial Infarction', 'Non-alcoholic Fatty Liver Disease-manage-Fibrosis', 'Cardiovascular Diseases-gained-Stroke', 'Tuberculosis-Reduce-Death', 'Diabetes Mellitus, Type 2-gained-Myocardial Infarction', 'Diabetes Mellitus, Type 2-gained-Stroke', 'Death-Reduce-Tuberculosis', 'Death-Reduce-HIV Infections', 'Carcinoma, Hepatocellular-necessitate-Chemical and Drug Induced Liver Injury', 'Periodontitis-activate-Inflammation', 'HIV Infections-activate-Inflammation', 'Neoplasms-validate-Neoplasm Metastasis', 'Primary Myelofibrosis-include-Myeloproliferative Disorders', 'Polycythemia Vera-include-Myeloproliferative Disorders', 'Thrombocythemia, Essential-include-Myeloproliferative Disorders', 'Intracranial Embolism-limit-Cerebrovascular Disorders', 'Infant, Newborn, Diseases-result-Cardiomyopathy, Hypertrophic', 'Liver Diseases-decrease-Death', 'Liver Diseases-obtained-Death', 'Carcinoma, Hepatocellular-obtained-Death', 'Mucocutaneous Lymph Node Syndrome-require-Constriction, Pathologic', 'Mucocutaneous Lymph Node Syndrome-require-Thrombosis', 'Mucocutaneous Lymph Node Syndrome-detect-Arterial Occlusive Diseases', 'Mucocutaneous Lymph Node Syndrome-detect-Myocardial Infarction', 'Carcinoma, Hepatocellular-increase-Death', 'Psychomotor Disorders-lead-Death', 'Psychomotor Disorders-lead-Respiratory Insufficiency', 'Alzheimer Disease-characterized-Inflammation', 'Neurodegenerative Diseases-characterized-Inflammation', 'Hyperglycemia-account-Death', 'Renal Insufficiency-include-Aneurysm', 'Cerebrovascular Disorders-include-Aneurysm', 'Chiari-Frommel Syndrome-associated-Glomerulonephritis', 'Glomerulonephritis-associated-Chiari-Frommel Syndrome', 'Chiari-Frommel Syndrome-increase-Glomerulonephritis', 'Chiari-Frommel Syndrome-associated-Death', 'Death-associated-Chiari-Frommel Syndrome', 'Chiari-Frommel Syndrome-increase-Death', 'Chiari-Frommel Syndrome-associated-Lupus Erythematosus, Systemic', 'Lupus Erythematosus, Systemic-associated-Chiari-Frommel Syndrome', 'Chiari-Frommel Syndrome-increase-Lupus Erythematosus, Systemic', 'Cerebral Infarction-include-Atrial Fibrillation', 'Epilepsy-face-Seizures', 'Buschke-Lowenstein Tumor-include-Skin Neoplasms', 'Ocular Motility Disorders-present-Deglutition Disorders', 'Fractures, Bone-crosschecked-Death', 'Death-record-Hypocalcemia', 'Asthma-termed-Asthma-Chronic Obstructive Pulmonary Disease Overlap Syndrome', 'Asthma-compare-Lung Diseases', 'Cerebrovascular Disorders-follow-Death', 'Alzheimer Disease-affected-Cerebrovascular Disorders', 'Neoplasm Metastasis-derived-Neoplasms', 'Liposarcoma-followed-Leiomyosarcoma', 'Venous Thrombosis-remain-Hemoglobinuria, Paroxysmal', 'Neoplasms-induce-Primary Ovarian Insufficiency', 'Neoplasms-render-Infertility, Female', 'Primary Ovarian Insufficiency-render-Infertility, Female', 'Death-manifest-Coronary Artery Disease', 'Stroke-manifest-Coronary Artery Disease', 'Hemoglobinuria, Paroxysmal-associated-Anemia, Aplastic', 'Anemia, Aplastic-associated-Hemoglobinuria, Paroxysmal', 'Hemoglobinuria, Paroxysmal-associated-Myelodysplastic Syndromes', 'Myelodysplastic Syndromes-associated-Hemoglobinuria, Paroxysmal', 'Low Back Pain-considered-Discitis', 'Rubella Syndrome, Congenital-abstract-Rubella', 'Eye Abnormalities-abstract-Rubella', 'Rubella Syndrome, Congenital-bind-Weight Loss', 'Rubella Syndrome, Congenital-manage-Rubella', 'Facial Dermatoses-include-Craniosynostoses', 'Facial Dermatoses-include-Hypertelorism', 'Growth Disorders-document-Dwarfism, Pituitary', 'Growth Disorders-document-Hypothyroidism', 'Dwarfism, Pituitary-document-Hypothyroidism', 'Hemophilia A-changing-Death', 'Hemophilia A-changing-Hemorrhage', 'Jaundice-increase-Death', 'Death-alter-Neurodegenerative Diseases', 'Carcinoma, Hepatocellular-manifest-Jaundice, Obstructive', 'Prostatic Neoplasms-affect-Death', 'Adenocarcinoma-include-Neoplasm Metastasis', 'Pain-utilize-Pain Insensitivity, Congenital', 'Niemann-Pick Disease, Type C-characterised-Neurodegenerative Diseases', 'Niemann-Pick Disease, Type C-characterised-Death', 'Niemann-Pick Disease, Type A-characterised-Neurodegenerative Diseases', 'Stroke-reported-Fibromuscular Dysplasia', 'Aneurysm-reported-Fibromuscular Dysplasia', 'Death-expected-Carcinoid Tumor', 'Death, Sudden-reported-Fibromuscular Dysplasia', 'Fibromuscular Dysplasia-identified-Kidney Diseases', 'Diabetes Mellitus-use-Glucose Intolerance', 'Diabetes Mellitus-stratify-Glucose Intolerance', 'Tooth, Impacted-cause-Leukemia', 'Diabetes, Gestational-avoid-Diabetes Mellitus', 'Prediabetic State-avoid-Diabetes Mellitus', 'Neoplasms-vary-Death', 'Death-represent-Neoplasms', 'Glioma-promote-Astrocytoma', 'Hypertension, Pulmonary-stay-Death', 'Osteopetrosis-lead-Bone Marrow Failure Disorders', 'Osteopetrosis-lead-Blindness', 'Diabetes Mellitus-advance-Prostatic Diseases', 'Kidney Diseases-advance-Prostatic Diseases', 'Hypotension-lead-Anemia', 'Maxillofacial Abnormalities-affected-Thalassemia', 'Death-occur-Thrombosis', 'Myocardial Infarction-result-Thrombosis', 'Osteoporosis-suffer-Back Pain', 'Osteoporosis-suffer-Osteolysis', 'Neoplasms-suffer-Back Pain', 'Back Pain-prevented-Osteoporosis', 'Back Pain-prevented-Neoplasms', 'Hemorrhage-occur-Ascites', 'Alzheimer Disease-experience-Hallucinations', 'Hallucinations-experience-Death', 'Dyslipidemias-reach-Hypertension', 'Kidney Diseases-taken-Diabetic Nephropathies', 'Inflammatory Bowel Diseases-make-Colonic Neoplasms', 'Bone Neoplasms-result-Stroke', 'Death-caused-Liver Failure', 'Death-caused-Short Bowel Syndrome', 'Death-caused-Peritoneal Neoplasms', 'Epilepsy-followed-Death', 'Long QT Syndrome-treated-Myocarditis', 'Death-examine-Headache Disorders, Secondary', 'Diabetes Mellitus-treated-Kidney Diseases', 'Neutropenia-lead-Fever', 'Rupture-increase-Hypertension', 'Rupture-increase-Lung Diseases', 'Rupture-increase-Aneurysm', 'Death-associated-Aneurysm, Ruptured', 'Aneurysm, Ruptured-associated-Death', 'Anemia-respond-Postpartum Hemorrhage', 'Fatigue-used-Hodgkin Disease', 'Neoplasm Metastasis-reduced-Pain', 'Fatigue-reduced-Pain', 'Fatigue-reported-Death', 'Pain-reported-Death', 'Pleural Effusion, Malignant-represent-Neoplasms', 'Genetic Diseases, Inborn-lead-Immunologic Deficiency Syndromes', 'Carotid Artery Injuries-treated-Bacterial Infections', 'Neoplasm Metastasis-caused-Neoplasms', 'Colitis, Ulcerative-admitted-Inflammatory Bowel Diseases', 'Death-compare-Colitis, Ulcerative', 'Colitis, Ulcerative-compare-Death', 'Death-observed-Colitis, Ulcerative', 'Colitis, Ulcerative-observed-Death', 'Colitis, Ulcerative-seem-Death', 'Hemorrhage-lead-Neoplasms', 'Dementia-adjusted-Death', 'Polycythemia Vera-distinguish-Thrombocytosis', 'Thrombocythemia, Essential-distinguish-Thrombocytosis', 'Death-increase-Acquired Immunodeficiency Syndrome', 'Acquired Immunodeficiency Syndrome-develop-Infections', 'Acquired Immunodeficiency Syndrome-develop-Thrombosis', 'Infections-develop-Thrombosis', 'Seizures-experience-Epilepsy', 'Dystonia-vary-Mesenteric Vascular Occlusion', 'End Stage Liver Disease-characterized-Biliary Dyskinesia', 'End Stage Liver Disease-observed-Carcinoma, Hepatocellular', 'Death-related-Myasthenia Gravis', 'Neoplasms-survive-Endocrine System Diseases', 'Neoplasms-survive-Cardiovascular Diseases', 'Myasthenia Gravis-experience-Muscle Weakness', 'Glucose Intolerance-mean-Diabetes Mellitus', 'Hemolysis-leave-Anemia', 'Glucose Intolerance-observed-Diabetes Mellitus', 'Cardiovascular Diseases-account-Turner Syndrome', 'Cardiovascular Diseases-promote-Neoplasms', 'Nerve Degeneration-associated-Creutzfeldt-Jakob Syndrome', 'Creutzfeldt-Jakob Syndrome-associated-Nerve Degeneration', 'Nerve Degeneration-associated-Encephalitis', 'Encephalitis-associated-Nerve Degeneration', 'Nerve Degeneration-associated-Brain Neoplasms', 'Brain Neoplasms-associated-Nerve Degeneration', 'Genetic Diseases, Inborn-cause-Inflammation', 'Nerve Degeneration-associated-Stroke', 'Stroke-associated-Nerve Degeneration', 'Liver Neoplasms-include-Neurodegenerative Diseases', 'Neoplasm Metastasis-make-Pain', 'Sepsis-correlate-Death', 'Obesity-contribute-Breast Neoplasms', 'Carcinoma, Ovarian Epithelial-include-Neoplasms', 'Sepsis-prove-Death', 'Sepsis-observed-Carcinoma, Squamous Cell', 'Death-observed-Carcinoma, Squamous Cell', 'Amyotrophic Lateral Sclerosis-remain-Death', 'Death-associated-Abnormalities, Drug-Induced', 'Abnormalities, Drug-Induced-associated-Death', 'Intracranial Hemorrhages-reported-Thrombocytopenia', 'Fractures, Bone-neglected-Osteoporosis', 'Osteoporosis-observe-Fractures, Bone', 'Hypertension-associate-Retinal Vein Occlusion', 'Retinal Vein Occlusion-associate-Hypertension', 'Amyloidosis-targeted-Alzheimer Disease', 'Necrosis-play-Neoplasms', 'Death-suffer-Gastrointestinal Hemorrhage', 'Death-determined-Epilepsy', 'Zoonoses-monetize-Cysticercosis', 'Hypotension-monetize-Cysticercosis', 'Metabolic Diseases-underperforming-Arthritis, Rheumatoid', 'Retinal Degeneration-seen-Alzheimer Disease', 'Hyperkinesis-stimulate-Stroke', 'Hyperkinesis-induce-Hypertension', 'Stroke-induce-Hypertension', 'Osteoarthritis-compared-Cerebral Palsy', 'Cerebral Palsy-include-Death', 'Hypothalamic Neoplasms-include-Unconsciousness', 'Cardiotoxicity-prevent-Heart Diseases', 'Neoplasm Metastasis-develop-Breast Neoplasms', 'Neoplasm Metastasis-develop-Hematologic Neoplasms', 'Breast Neoplasms-develop-Hematologic Neoplasms', 'Neoplasm Metastasis-decrease-Headache Disorders, Secondary', 'Atherosclerosis-change-Cardiovascular Diseases', 'Death-become-Cardiovascular Diseases', 'Diabetes Mellitus-estimated-Obesity', 'Diabetes Mellitus-vary-Cardiovascular Diseases', 'Obesity-identified-Liver Failure', 'Obesity-identified-Hemochromatosis', 'Bloom Syndrome-characterized-Growth Disorders', 'Turner Syndrome-include-Growth Disorders', 'Turner Syndrome-include-Sexual Infantilism', 'Turner Syndrome-include-Metabolic Diseases', 'Heart Failure-coming-Obesity', 'Seizures-explain-Death', 'Myotonic Dystrophy-undergo-Diabetes Mellitus', 'Hypesthesia-suited-Neoplasms', 'Cardiovascular Diseases-deteriorate-Diabetes Mellitus', 'Diabetes Mellitus, Type 2-deteriorate-Diabetes Mellitus', 'Obesity-cut-Coronary Artery Disease', 'Myocardial Infarction-prove-Coronary Stenosis', 'Coronary Stenosis-prove-Coronary Artery Disease', 'Death-study-Sepsis', 'Cardiovascular Diseases-remain-Ventricular Remodeling', 'Heart Failure-remain-Ventricular Remodeling', 'Death-reduced-HIV Infections', 'Heart Failure-reduce-Ventricular Remodeling', 'Respiratory Insufficiency-account-Death', 'Death-evaluate-Prader-Willi Syndrome', 'Prader-Willi Syndrome-show-Death', 'Death-treat-Wounds and Injuries', 'Heart Failure-render-Death', 'Ischemia-treat-Wounds and Injuries', 'Heart Failure-render-Ischemia', 'Wounds and Injuries-treat-Heart Failure', 'Diabetes Mellitus-continue-Heart Failure', 'Hypertension-continue-Heart Failure', 'Coronary Artery Disease-continue-Heart Failure', 'Cystic Fibrosis-target-Genetic Diseases, Inborn', 'Gout-affect-Death', 'Obesity-indicate-Death', 'Diabetes Mellitus-occur-Alcoholism', 'Acromegaly-appear-Fractures, Bone', 'Acromegaly-appear-Hypogonadism', 'Chronic Disease-improve-Death', 'Death-attributed-Edema', 'Neoplasms-perform-Death', 'Noonan Syndrome-end-Death', 'Marfan Syndrome-lead-Aortic Aneurysm', 'Marfan Syndrome-lead-Cardiovascular Diseases', 'Obesity, Maternal-associated-Obesity', 'Obesity-associated-Obesity, Maternal', 'Obesity, Maternal-associated-Hypertension', 'Hypertension-associated-Obesity, Maternal', 'Hypertension, Pulmonary-register-Pregnancy Complications, Infectious', 'Myelodysplastic Syndromes-occur-Anemia', 'Lymphoma-retain-Neoplasms', 'Hematologic Diseases-lead-Infections', 'Hematologic Diseases-lead-Hemorrhage', 'Hematologic Diseases-progress-Leukemia, Myeloid, Acute', 'Gaucher Disease-result-Hematologic Diseases', 'Gaucher Disease-lead-Fanconi Syndrome', 'Mitochondrial Diseases-play-Diabetes Mellitus', 'Mitochondrial Diseases-play-Neoplasms', 'Back Pain-pushed-Aortic Aneurysm, Abdominal', 'Renal Insufficiency, Chronic-referred-Arteriovenous Fistula', 'Renal Insufficiency, Chronic-create-Arteriovenous Fistula', 'Disorders of Excessive Somnolence-linked-Demyelinating Diseases', 'Thrombocytopenia-predict-Hemorrhage', 'Inflammation-related-Disorders of Excessive Somnolence', 'Mesothelioma-included-Neoplasms', 'Mesothelioma-present-Neoplasms', 'Fibrosis-hospitalized-Ulcer', 'Hypertension-hospitalized-Ulcer', 'Leg Ulcer-associated-Death', 'Death-associated-Leg Ulcer', 'Leg Ulcer-associated-Renal Insufficiency', 'Renal Insufficiency-associated-Leg Ulcer', 'Gangrene-associated-Renal Insufficiency', 'Renal Insufficiency-associated-Gangrene', 'Fibrosis-associated-Peptic Ulcer', 'Peptic Ulcer-associated-Fibrosis', 'Death-exceed-Fibrosis', 'Hyperandrogenism-affect-Hirsutism', 'Hyperandrogenism-affect-Acne Vulgaris', 'HIV Infections-induce-Immunologic Deficiency Syndromes', 'HIV Infections-damaged-Respiratory Tract Infections', 'Muscle Weakness-control-Cough', 'Nervous System Diseases-caused-Edema', 'Nervous System Diseases-associated-Brain Neoplasms', 'Brain Neoplasms-associated-Nervous System Diseases', 'Edema-associated-Brain Neoplasms', 'Brain Neoplasms-associated-Edema', 'Obesity-related-Dementia', 'Obesity-compare-Dementia', 'Hematologic Neoplasms-associated-Thrombocytopenia', 'Thrombocytopenia-associated-Hematologic Neoplasms', 'Genetic Diseases, X-Linked-characterized-Muscle Weakness', 'Genetic Diseases, X-Linked-characterized-Diabetic Neuropathies', 'Leukemia, Myelomonocytic, Chronic-classified-Myelodysplastic Syndromes', 'Hematologic Neoplasms-classified-Myelodysplastic Syndromes', 'Thrombocytopenia-include-Postpartum Hemorrhage', 'Asthma-diagnosed-Airway Obstruction', 'Asthma-diagnosed-Bronchial Diseases', 'Asthma-diagnosed-Drug Hypersensitivity', 'Asthma-reflect-Airway Obstruction', 'Asthma-reflect-Bronchial Diseases', 'Hepatitis C-cause-HIV Infections', 'Venous Thrombosis-depend-Neoplasms', 'Sick Sinus Syndrome-associated-Ventricular Premature Complexes', 'Ventricular Premature Complexes-associated-Sick Sinus Syndrome', 'Sick Sinus Syndrome-associated-Takotsubo Cardiomyopathy', 'Takotsubo Cardiomyopathy-associated-Sick Sinus Syndrome', 'Atrioventricular Block-associated-Takotsubo Cardiomyopathy', 'Takotsubo Cardiomyopathy-associated-Atrioventricular Block', 'Takotsubo Cardiomyopathy-lead-Cardiomegaly', 'Ventricular Premature Complexes-induced-Takotsubo Cardiomyopathy', 'Ventricular Premature Complexes-lead-Cardiomegaly', 'Noonan Syndrome-include-Sepsis', 'Thrombocytopenia-include-Sepsis', 'Intracranial Aneurysm-determined-Aneurysm', 'Fanconi Anemia-develop-Bone Marrow Failure Disorders', 'Neoplasms-include-Neoplasm Metastasis', 'Neoplasms-confirm-Neoplasm Metastasis', 'Alzheimer Disease-make-Heart Failure', 'Prostatic Neoplasms-avoid-Postpartum Hemorrhage', 'Neoplasms-avoid-Postpartum Hemorrhage', 'Puberty, Delayed-indicate-Hypogonadism', 'Thalassemia-treat-Endocrine System Diseases', 'Fatigue-reported-Disorders of Excessive Somnolence', 'Diabetic Nephropathies-reduce-Kidney Failure, Chronic', 'Intracranial Aneurysm-include-Rupture', 'Intracranial Aneurysm-include-Embolism', 'Intracranial Aneurysm-include-Thrombosis', 'Ischemia-threaten-Intracranial Aneurysm', 'Ischemia-threaten-Thrombosis', 'Aneurysm-represent-Hypotension', 'Immunologic Deficiency Syndromes-experience-Headache Disorders, Secondary', 'Immunologic Deficiency Syndromes-experience-Xerostomia', 'Myositis-determined-Neoplasms', 'Sarcoma-done-Arterial Occlusive Diseases', 'Sweet Syndrome-associated-Hematologic Diseases', 'Hematologic Diseases-associated-Sweet Syndrome', 'Acquired Immunodeficiency Syndrome-estimated-Infections', 'Seizures-lower-Death', 'Thalassemia-become-Coronary Artery Disease', 'Hypertension-cause-Death, Sudden', 'Gait Disorders, Neurologic-associated-Hypesthesia', 'Hypesthesia-associated-Gait Disorders, Neurologic', 'Li-Fraumeni Syndrome-result-Infections', 'Prostatic Neoplasms-detect-Neoplasms', 'Muscle Weakness-lead-Paralysis', 'Ovarian Neoplasms-inhibit-Neoplasms', 'Alcoholism-include-Pancreatitis', 'Alcoholism-modelled-Pancreatitis', 'Alcoholism-include-Gastritis', 'Alcoholism-include-Neoplasms', 'Alcoholism-include-Gastroesophageal Reflux', 'Alcoholism-include-Cardiomyopathy, Alcoholic', 'Alcoholism-include-Peripheral Nervous System Diseases', 'Alcoholism-include-Psychoses, Alcoholic', 'Hemangioblastoma-include-Vascular Neoplasms', 'End Stage Liver Disease-caused-Hepatitis C', 'Hepatitis C-caused-Liver Failure', 'HIV Infections-inject-Death', 'HIV Infections-arise-Hepatitis C', 'Infections-inject-Death', 'Infections-arise-Hepatitis C', 'Myocardial Infarction-cause-Cardiovascular Diseases', 'Death-prevent-Myocardial Infarction', 'Neoplasms-noted-Mucositis', 'Myocardial Infarction-include-Mesenteric Vascular Occlusion', 'Stroke-include-Mesenteric Vascular Occlusion', 'Ischemia-include-Mesenteric Vascular Occlusion', 'Angina, Stable-include-Mesenteric Vascular Occlusion', 'Death-divide-Diabetes Mellitus, Type 1', 'Melanoma-start-Neoplasms', 'Melanoma-increase-Neoplasm Metastasis', 'Neoplasms-indicate-Death', 'Primary Myelofibrosis-associated-Thrombocytosis', 'Thrombocytosis-associated-Primary Myelofibrosis', 'Amenorrhea-observed-Azoospermia', 'Hypothyroidism-reported-Thyroid Diseases', 'Lung Diseases-cause-Death', 'Mucositis-referred-Graft vs Host Disease', 'Nervous System Diseases-noted-Nausea', 'Nervous System Diseases-noted-Vomiting', 'Death-resected-Aortic Aneurysm', 'Arachnodactyly-crumple-Contracture', 'Arachnodactyly-crumple-Myalgia', 'Retinal Detachment-studied-Acquired Immunodeficiency Syndrome', 'Meningeal Carcinomatosis-examined-Drug-Related Side Effects and Adverse Reactions', 'Drug-Related Side Effects and Adverse Reactions-administered-Carcinosarcoma', 'Hypothalamic Neoplasms-appear-Drug-Related Side Effects and Adverse Reactions', 'Drug-Related Side Effects and Adverse Reactions-increase-Meningeal Carcinomatosis', 'Brain Diseases-range-Language Development Disorders', 'Brain Diseases-range-Quadriplegia', 'Leukemia, Myelogenous, Chronic, BCR-ABL Positive-transform-Chronic Disease', 'Critical Illness-marked-Ischemia', 'Critical Illness-marked-Pain', 'Critical Illness-marked-Ulcer', 'Critical Illness-marked-Gangrene', 'Peripheral Arterial Disease-marked-Ischemia', 'Peripheral Arterial Disease-marked-Pain', 'Peripheral Arterial Disease-marked-Ulcer', 'Peripheral Arterial Disease-marked-Gangrene', 'Leukemia, Myelogenous, Chronic, BCR-ABL Positive-considered-Neoplasms', 'Neoplasm Metastasis-demonstrate-Pain', 'Neoplasm Metastasis-include-Fractures, Bone', 'Cerebrovascular Disorders-underlie-Cardiovascular Diseases', 'Cachexia-diminish-Neoplasms', 'Cerebrovascular Disorders-underlie-Neoplasms', 'Hereditary Breast and Ovarian Cancer Syndrome-diminish-Neoplasms', 'Thrombosis-underlie-Death', 'Thrombosis-underlie-Cardiovascular Diseases', 'Thrombosis-underlie-Neoplasms', 'Immunologic Deficiency Syndromes-present-Hyperammonemia', 'Immunologic Deficiency Syndromes-present-Acidosis', 'Infections-follow-Neutropenia', 'Dysautonomia, Familial-manifest-Ischemic Attack, Transient', 'Dysautonomia, Familial-manifest-Stroke', 'Dysautonomia, Familial-manifest-Hearing Loss', 'Heart Diseases-characterized-Chemical and Drug Induced Liver Injury', 'Heart Diseases-characterized-Arrhythmias, Cardiac', 'Heart Diseases-characterized-Heart Failure', 'Wounds and Injuries-investigate-Brain Injuries, Traumatic', 'Osteoarthritis-affect-Ataxia', 'HIV Infections-live-Alcoholism', 'HIV Infections-live-Fatty Liver', 'HIV Infections-live-Hepatitis B', 'Fatty Liver-develop-HIV Infections', 'Cardiovascular Diseases-trigger-Coronary Artery Disease', 'Coronary Artery Disease-trigger-Cardiovascular Diseases', 'Movement Disorders-related-Joint Diseases', 'Respiratory Distress Syndrome-inhibit-Inflammation', 'Neurodegenerative Diseases-take-Neoplasms', 'Stroke-estimate-Hypertension', 'Lung Diseases-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-Lung Diseases', 'Inflammation-underlie-Rheumatic Diseases', 'Osteoporosis-avoid-Fractures, Bone', 'Heart Failure-diagnosed-Cachexia', 'Hip Fractures-need-Osteoporosis', 'Hyperglycemia-minimize-Hypoglycemia', 'Kidney Diseases-differ-Neoplasms', 'Radiculopathy-develop-Paralysis', 'Radiculopathy-develop-Edema', 'Malnutrition-affect-Death', 'Death-determined-Malnutrition', 'Death-calculate-Malnutrition', 'Ovarian Neoplasms-demonstrate-Carcinoma, Ovarian Epithelial', 'Carcinoma, Ovarian Epithelial-represent-Ovarian Neoplasms', 'Lung Diseases-lead-Fibrosis', 'Lung Diseases-lead-Idiopathic Pulmonary Fibrosis', 'Death-used-Heart Failure', 'Death-impact-Heart Failure', 'Airway Obstruction-result-Hematuria', 'Airway Obstruction-result-Anemia', 'Glioma-correlate-Neoplasms', 'Facial Pain-occur-Head and Neck Neoplasms', 'Death-improve-Neoplasms', 'Pain-result-Neoplasms', 'Neoplasms-reduce-Pain', 'Inflammation-include-Pulmonary Arterial Hypertension', 'Facial Pain-involve-Cancer Pain', 'Facial Pain-involve-Pain', 'Neoplasms-characterized-Pulmonary Arterial Hypertension', 'Neoplasms-prompt-Pulmonary Arterial Hypertension', 'Aortic Aneurysm-undergo-Death', 'Cardiotoxicity-diagnose-Neurologic Manifestations', 'Cardiotoxicity-clarify-Wounds and Injuries', 'Cardiotoxicity-use-Breast Neoplasms', 'Neurologic Manifestations-use-Breast Neoplasms', 'Wounds and Injuries-use-Breast Neoplasms', 'Gingival Overgrowth-occur-Neoplasms', 'Fractures, Open-decrease-Death', 'Infections-emerge-HIV Infections', 'Lupus Erythematosus, Systemic-related-Drug-Related Side Effects and Adverse Reactions', 'Lupus Erythematosus, Systemic-contribute-Lupus Nephritis', 'Drug-Related Side Effects and Adverse Reactions-contribute-Lupus Nephritis', 'Blood Platelet Disorders-establish-Neoplasms', 'Neoplasms-outweigh-Breast Neoplasms', 'Cardiovascular Diseases-develop-Marfan Syndrome', 'Neoplasms-result-Vaginal Fistula', 'Death-driven-Nervous System Diseases', 'Death-related-Respiratory Tract Diseases', 'Spinal Diseases-cause-Neurologic Manifestations', 'Spinal Diseases-cause-Mobility Limitation', 'Bronchopulmonary Dysplasia-lead-Lung Diseases', 'Bronchopulmonary Dysplasia-discussed-Death', 'Neuroaxonal Dystrophies-lead-Movement Disorders', 'Diarrhea-include-Infections', 'Tuberculosis-include-Infections', 'Aortic Aneurysm, Abdominal-include-Aneurysm', 'Diarrhea-include-Tuberculosis', 'Leishmaniasis-include-Tuberculosis', 'Cholestasis-lead-Fibrosis', 'Death-use-Lung Neoplasms', 'Death-calculate-Colorectal Neoplasms', 'Death-calculate-Cardiovascular Diseases', 'Coinfection-expressed-Infections', 'Mitochondrial Diseases-noted-Death', 'Osteoarthritis-cause-Edema', 'Neurodegenerative Diseases-cause-Edema', 'Disease-considered-Osteoarthritis', 'Inflammation-cause-Edema', 'HIV Infections-remain-Lymphoma', 'HIV Infections-remain-Hodgkin Disease', 'HIV Infections-remain-Lymphoma, B-Cell', 'HIV Infections-remain-Burkitt Lymphoma', 'HIV Infections-remain-Lymphoma, T-Cell, Peripheral', 'HIV Infections-affect-Lymphoma, T-Cell, Peripheral', 'HIV Infections-identified-Neoplasms', 'HIV Infections-associated-Burkitt Lymphoma', 'Burkitt Lymphoma-associated-HIV Infections', 'HIV Infections-associated-Lymphoma, T-Cell, Peripheral', 'Lymphoma, T-Cell, Peripheral-associated-HIV Infections', 'HIV Infections-associated-Lymphoma', 'Lymphoma-associated-HIV Infections', 'HIV Infections-associated-Lymphoma, AIDS-Related', 'Lymphoma, AIDS-Related-associated-HIV Infections', 'Hodgkin Disease-associated-Acquired Immunodeficiency Syndrome', 'Acquired Immunodeficiency Syndrome-associated-Hodgkin Disease', 'Burkitt Lymphoma-associated-Acquired Immunodeficiency Syndrome', 'Acquired Immunodeficiency Syndrome-associated-Burkitt Lymphoma', 'Lymphoma, T-Cell, Peripheral-associated-Acquired Immunodeficiency Syndrome', 'Acquired Immunodeficiency Syndrome-associated-Lymphoma, T-Cell, Peripheral', 'Lymphoma-associated-Acquired Immunodeficiency Syndrome', 'Acquired Immunodeficiency Syndrome-associated-Lymphoma', 'Acquired Immunodeficiency Syndrome-associated-Lymphoma, AIDS-Related', 'Lymphoma, AIDS-Related-associated-Acquired Immunodeficiency Syndrome', 'Heart Arrest-bear-Glioma', 'Neoplasms-induce-Glioma', 'Neoplasms-bear-Glioma', 'Osteoporosis-determine-Fractures, Bone', 'Hemarthrosis-prevent-Hemophilia A', 'Hemarthrosis-become-Hemophilia A', 'Granulomatous Disease, Chronic-lead-Inflammation', 'Pancreatitis-offered-Diabetes Mellitus', 'Diabetes Mellitus-lead-Insulin Resistance', 'Ovarian Neoplasms-associated-Primary Ovarian Insufficiency', 'Primary Ovarian Insufficiency-associated-Ovarian Neoplasms', 'Hashimoto Disease-found-Gastrointestinal Diseases', 'Hashimoto Disease-found-Osteoporosis', 'Congenital Abnormalities-occur-Turner Syndrome', 'Death-result-Viremia', 'Death-related-Psoriasis', 'Death-recorded-Psoriasis', 'Death-vary-Psoriasis', 'Death-observed-Psoriasis', 'Brain Injuries, Traumatic-associated-Infections', 'Infections-associated-Brain Injuries, Traumatic', 'Neurofibrosarcoma-occur-Neurofibroma', 'Neurofibrosarcoma-occur-Genetic Diseases, Inborn', 'Sarcoma-occur-Neurofibroma', 'Cystic Fibrosis-cause-Death', 'Sarcoma-occur-Genetic Diseases, Inborn', 'Neurofibroma-occur-Genetic Diseases, Inborn', 'Achondroplasia-attributed-Osteosarcoma', 'Chronic Disease-achieve-Diabetes Mellitus', 'Paraproteinemias-lead-Neoplasms', 'Paraproteinemias-lead-Multiple Myeloma', 'Death-referred-Obesity', 'Prostatic Neoplasms-avoid-Prostatic Hyperplasia', 'Wounds and Injuries-associate-Spinal Cord Injuries', 'Spinal Cord Injuries-associate-Wounds and Injuries', 'Peroneal Neuropathies-characterized-Muscle Weakness', 'Peroneal Neuropathies-characterized-Chest Pain', 'Rare Diseases-caused-Immunologic Deficiency Syndromes', 'Metabolism, Inborn Errors-associate-Nervous System Diseases', 'Nervous System Diseases-associate-Metabolism, Inborn Errors', 'Metabolism, Inborn Errors-generalized-Nervous System Diseases', 'Metabolism, Inborn Errors-associate-Growth Disorders', 'Growth Disorders-associate-Metabolism, Inborn Errors', 'Metabolism, Inborn Errors-generalized-Cyanosis', 'Nervous System Diseases-associate-Cyanosis', 'Cyanosis-associate-Nervous System Diseases', 'Growth Disorders-associate-Cyanosis', 'Cyanosis-associate-Growth Disorders', 'Hypersensitivity, Immediate-result-Uniparental Disomy', 'Cardiotoxicity-lead-Heart Failure', 'Parkinson Disease, Secondary-refer-Nervous System Diseases', 'Parkinson Disease, Secondary-refer-Hypokinesia', 'Parkinson Disease, Secondary-refer-Muscle Rigidity', 'Parkinson Disease, Secondary-refer-Tremor', 'Nervous System Diseases-embrace-Hypokinesia', 'Nervous System Diseases-embrace-Muscle Rigidity', 'Nervous System Diseases-embrace-Tremor', 'Parkinson Disease-considered-Dystonia', 'Aneurysm-investigate-Aortic Diseases', 'Neoplasms-propagated-Immunologic Deficiency Syndromes', 'Hemolytic-Uremic Syndrome-seen-Heart Failure', 'Renal Insufficiency, Chronic-seen-Heart Failure', 'Diabetes Mellitus-follow-Pulmonary Disease, Chronic Obstructive', 'Heart Failure-escape-Edema', 'Metabolic Diseases-metabolise-Atherosclerosis', 'Metabolic Diseases-metabolise-Heart Diseases', 'Diabetes Mellitus-used-Coronaviridae Infections', 'Arthropathy, Neurogenic-occur-Peripheral Nervous System Diseases', 'Arthritis-occur-Peripheral Nervous System Diseases', 'Arthropathy, Neurogenic-associated-HIV Infections', 'HIV Infections-associated-Arthropathy, Neurogenic', 'Polyneuropathies-associated-HIV Infections', 'HIV Infections-associated-Polyneuropathies', 'Neoplasms-published-Thyroid Neoplasms', 'Leukemia-published-Thyroid Neoplasms', 'Lung Diseases-influence-Death', 'Osteoporosis-associate-Amenorrhea', 'Amenorrhea-associate-Osteoporosis', 'Alzheimer Disease-disturbed-Neurodegenerative Diseases', 'Death-compare-Fibrosis', 'Fibrosis-experience-Death', 'Fabry Disease-play-Autoimmune Diseases', 'Death-require-Stenosis, Pulmonary Artery', 'Thrombosis-associated-Fabry Disease', 'Fabry Disease-associated-Thrombosis', 'Mesenteric Vascular Occlusion-involve-Hemorrhage', 'Thrombocytosis-characterized-Hemorrhage', 'Myeloproliferative Disorders-characterized-Hemorrhage', 'Venous Thrombosis-represent-Hemorrhage', 'Arthritis, Rheumatoid-give-Fractures, Bone', 'Obesity-accelerate-Heart Diseases', 'Atrial Fibrillation-take-Stroke', 'Turner Syndrome-associated-Chromosome Aberrations', 'Chromosome Aberrations-associated-Turner Syndrome', 'Genetic Diseases, Inborn-associated-Chromosome Aberrations', 'Chromosome Aberrations-associated-Genetic Diseases, Inborn', 'Diabetes Mellitus, Type 2-seen-Hypertension', 'Diabetes Mellitus, Type 2-seen-Cardiovascular Diseases', 'Ocular Hypertension-reduce-Blindness', 'Cystic Fibrosis-develop-Diabetes Mellitus', 'Diabetes Mellitus-share-Diabetes Mellitus, Type 2', 'Ulcer-excluded-Osteomyelitis', 'Arthritis, Rheumatoid-yield-Death', 'Myocardial Infarction-increase-Heart Failure', 'Death-use-Heart Diseases', 'Death-describe-Heart Diseases', 'Abnormalities, Drug-Induced-develop-Glaucoma', 'Opportunistic Infections-involve-Acquired Immunodeficiency Syndrome', 'Opportunistic Infections-diagnosed-Acquired Immunodeficiency Syndrome', 'Acquired Immunodeficiency Syndrome-diagnosed-Infections', 'Death-caused-Colitis, Ulcerative', 'Budd-Chiari Syndrome-associated-Bile Duct Diseases', 'Bile Duct Diseases-associated-Budd-Chiari Syndrome', 'Dyslipidemias-cause-Atherosclerosis', 'Breast Neoplasms-known-Neoplasms', 'Lung Diseases-increase-Cystic Fibrosis', 'Dyslipidemias-compare-Cardiovascular Diseases', 'Dyslipidemias-compare-Diabetes Mellitus', 'Chemical and Drug Induced Liver Injury-progress-Liver Failure', 'Gastrointestinal Diseases-reduce-Dihydropyrimidine Dehydrogenase Deficiency', 'Anemia, Sickle Cell-associated-Drug-Related Side Effects and Adverse Reactions', 'Drug-Related Side Effects and Adverse Reactions-associated-Anemia, Sickle Cell', 'Anemia, Sickle Cell-halt-Death', 'Respiratory Tract Infections-play-Cystic Fibrosis', 'Lung Diseases-cause-Chronic Disease', 'Thrombocytosis-occur-Myeloproliferative Disorders', 'Thrombocytosis-present-Myelodysplastic Syndromes', 'Hemorrhage-observed-Thrombocytosis', 'Hemorrhage-associated-Polycythemia Vera', 'Polycythemia Vera-associated-Hemorrhage', 'Thrombocytosis-associated-Polycythemia Vera', 'Polycythemia Vera-associated-Thrombocytosis', 'Neutropenia-observed-Leukopenia', 'Neutropenia-delay-Diarrhea', 'Neutropenia-observed-Nausea', 'Neutropenia-observed-Vomiting', 'Extranodal Extension-seen-Lymphatic Diseases', 'Leukopenia-delay-Diarrhea', 'Neutropenia-develop-Diarrhea', 'Diarrhea-delay-Nausea', 'Diarrhea-develop-Sepsis', 'Diarrhea-delay-Vomiting', 'Neutropenia-develop-Sepsis', 'Neoplasm Metastasis-seen-Neoplasms', 'Osteoporosis-prevent-Hip Fractures', 'Colorectal Neoplasms-study-Neoplasms', 'Colorectal Neoplasms-arise-Adenoma', 'Colorectal Neoplasms-proceed-Neoplasms', 'Colorectal Neoplasms-study-Carcinogenesis', 'Adenoma-proceed-Neoplasms', 'Oculocerebrorenal Syndrome-relieve-Jaundice', 'Carcinoma, Hepatocellular-identify-Liver Failure', 'Carcinoma, Hepatocellular-reflect-Fibrosis', 'Carcinoma, Hepatocellular-reflect-Neoplasms', 'Carcinoma, Hepatocellular-reflect-Chemical and Drug Induced Liver Injury', 'Sleep Apnea Syndromes-link-Hypertension', 'Sleep Apnea Syndromes-contribute-Death', 'Sleep Apnea Syndromes-contribute-Coronary Artery Disease', 'Infections-result-Kidney Diseases', 'Classical Lissencephalies and Subcortical Band Heterotopias-described-Abnormalities, Drug-Induced', 'Classical Lissencephalies and Subcortical Band Heterotopias-described-Lissencephaly', 'Drug-Related Side Effects and Adverse Reactions-bear-Leukemia', 'Neoplasms-bear-Leukemia', 'Kidney Failure, Chronic-experience-Polycystic Kidney Diseases', 'Genetic Diseases, Inborn-provide-Brain Damage, Chronic', 'Drug Hypersensitivity-correlate-Asthma', 'Arthritis, Rheumatoid-occur-Death', 'Amyloidosis-related-Cardiovascular Diseases', 'Amyloidosis-related-Heart Failure', 'Amyloidosis-related-Arrhythmias, Cardiac', 'Amyloidosis-related-Hypotension', 'Amyloidosis-related-Malabsorption Syndromes', 'Death-occur-Gastrointestinal Diseases', 'Neurotoxicity Syndromes-treated-Nervous System Diseases', 'Ovarian Neoplasms-demonstrated-Neoplasms', 'Alzheimer Disease-increased-Death', 'Neoplasms-observed-Infections', 'Neoplasms-observed-Malnutrition', 'Alzheimer Disease-advance-Dementia', 'Seizures-prevent-Malnutrition', 'Neoplasms-focus-Colorectal Neoplasms', 'Neoplasms-focus-Lung Neoplasms', 'Diabetes Mellitus-avoid-Osteomyelitis', 'Genetic Diseases, Inborn-suspected-Aortic Valve Stenosis', 'Neoplasms-develop-Dementia', 'Death-transition-Dementia', 'Neoplasms-transition-Dementia', 'Renal Insufficiency-associated-Arrhythmias, Cardiac', 'Arrhythmias, Cardiac-associated-Renal Insufficiency', 'Cardiomyopathies-associated-Arrhythmias, Cardiac', 'Arrhythmias, Cardiac-associated-Cardiomyopathies', 'Cardiomyopathies-associated-Stroke', 'Stroke-associated-Cardiomyopathies', 'Pulmonary Disease, Chronic Obstructive-facilitated-Lung Diseases', 'Weight Loss-result-Immunologic Deficiency Syndromes', 'Weight Loss-increase-Amyotrophic Lateral Sclerosis', 'Infertility, Female-cause-Nervous System Diseases', 'Renal Insufficiency, Chronic-include-Coronary Artery Disease', 'Learning Disabilities-determine-Deglutition Disorders', 'Primary Ovarian Insufficiency-considered-Infertility, Female', 'Turner Syndrome-associated-Amenorrhea', 'Amenorrhea-associated-Turner Syndrome', 'Neurodegenerative Diseases-linked-Amyotrophic Lateral Sclerosis', 'Neurodegenerative Diseases-linked-Muscular Dystrophies', 'Amyotrophic Lateral Sclerosis-linked-Muscular Dystrophies', 'Death-increase-Seizures', 'HIV Infections-considered-Central Nervous System Neoplasms', 'Heart Failure-constitute-Arrhythmias, Cardiac', 'Huntington Disease-caused-Amyotrophic Lateral Sclerosis', 'Takotsubo Cardiomyopathy-list-Death', 'Cholangitis, Sclerosing-identify-Cholangiocarcinoma', 'Cystic Fibrosis-increase-Malabsorption Syndromes', 'Hepatitis, Autoimmune-include-Liver Diseases', 'Liver Cirrhosis, Biliary-include-Liver Diseases', 'Cholangitis, Sclerosing-include-Liver Diseases', 'Neoplasm Metastasis-lead-Nervous System Diseases', 'Pain-lead-Nervous System Diseases', 'Communicable Diseases-destroy-Neoplasms', 'Communicable Diseases-become-Neoplasms', 'Spinal Injuries-prevent-Scoliosis', 'Kidney Diseases-associated-Angiokeratoma', 'Angiokeratoma-associated-Kidney Diseases', 'Neoplasms-reveal-Colorectal Neoplasms', 'Kidney Diseases-compromise-Death', 'Heart Diseases-compromise-Death', 'Wounds and Injuries-lead-Osteoarthritis', 'Obesity-create-Osteoarthritis', 'Hyperlipoproteinemia Type II-cause-Atherosclerosis', 'Atrial Fibrillation-increase-Peripheral Arterial Disease', 'Death-divided-Infections', 'Death-divided-Liver Diseases', 'Death-divided-Pancreatitis', 'Death-divided-Renal Insufficiency', 'Death-divided-Death, Sudden', 'Death-divided-Myocardial Infarction', 'Neuronal Ceroid-Lipofuscinoses-used-Lysosomal Storage Diseases', 'Viremia-last-Infections', 'Lymphoma, B-Cell-include-Lymphoma', 'Lymphoma, B-Cell-include-Lymphoma, B-Cell, Marginal Zone', 'Muscular Atrophy, Spinal-represent-Death', 'Motor Neuron Disease-represent-Death', 'Infections-hover-HIV Infections', 'Heart Failure-searched-Polycystic Ovary Syndrome', 'Ovarian Neoplasms-include-Death', 'Multiple Endocrine Neoplasia-develop-Neoplasms', 'Multiple Endocrine Neoplasia-develop-Neuroendocrine Tumors', 'Genetic Diseases, Inborn-develop-Neoplasms', 'Genetic Diseases, Inborn-associated-Neuroendocrine Tumors', 'Neuroendocrine Tumors-associated-Genetic Diseases, Inborn', 'Genetic Diseases, Inborn-develop-Neuroendocrine Tumors', 'Neoplasms-transform-Glioma', 'Death-shift-Neuroendocrine Tumors', 'Breast Neoplasms-derived-Neoplasms', 'Neoplasms-lead-Drug-Related Side Effects and Adverse Reactions', 'Death-reveal-Diabetes Mellitus', 'Death-reveal-Renal Insufficiency', 'Death-reveal-Myocardial Infarction', 'Neoplasms-undergo-Barrett Esophagus', 'Acidosis-persist-Hyperlactatemia', 'Acidosis-develop-Kidney Diseases', 'Multiple Sclerosis-experience-Metabolic Diseases', 'Death-show-Acidosis', 'Multiple Sclerosis-contribute-Neurologic Manifestations', 'Metabolic Diseases-contribute-Neurologic Manifestations', 'Neuralgia-cited-Sleep Wake Disorders', 'Spinal Cord Injuries-include-Sleep Wake Disorders', 'Neoplasms-base-Heart Septal Defects, Atrial', 'Diabetes Mellitus-receive-Neoplasms', 'Diabetes Mellitus-play-Neoplasms', 'Diabetes Mellitus-receive-Hypoglycemia', 'Diabetes Mellitus-receive-Hyperglycemia', 'Neoplasms-receive-Hypoglycemia', 'Neoplasms-receive-Hyperglycemia', 'Death-mapped-Nervous System Diseases', 'Death-mapped-Stroke', 'Cardiovascular Diseases-cause-Aortic Aneurysm', 'Aortic Aneurysm-lead-Heart Failure', 'Aortic Valve Insufficiency-lead-Heart Failure', 'Diabetes Mellitus-treat-Diabetic Foot', 'Asthma-include-Inflammation', 'Multiple Sclerosis-identified-Death', 'Anemia, Sickle Cell-suffer-Kidney Failure, Chronic', 'Glioblastoma-screened-Neoplasms', 'Neoplasms-screened-Glioblastoma', 'Inflammation-drive-Drug Hypersensitivity', 'Weight Loss-increase-Diabetes Mellitus', 'Heart Block-used-Pain', 'Heart Block-used-Pelvic Neoplasms', 'Pain-related-Pelvic Neoplasms', 'Paraplegia-compared-Quadriplegia', 'Kidney Diseases-managed-Renal Insufficiency, Chronic', 'Kidney Diseases-managed-Diabetes Mellitus', 'Diabetic Nephropathies-managed-Renal Insufficiency, Chronic', 'Diabetic Nephropathies-managed-Diabetes Mellitus', 'Respiratory Insufficiency-avoid-Multiple Organ Failure', 'Obesity-balanced-Death', 'Amyotrophic Lateral Sclerosis-bring-Muscular Atrophy', 'Amyotrophic Lateral Sclerosis-bring-Paralysis', 'Amyotrophic Lateral Sclerosis-bring-Death', 'Nervous System Diseases-receive-Precursor Cell Lymphoblastic Leukemia-Lymphoma', 'Neurodegenerative Diseases-bring-Muscular Atrophy', 'Neurodegenerative Diseases-bring-Paralysis', 'Neurodegenerative Diseases-bring-Death', 'Nerve Degeneration-bring-Muscular Atrophy', 'Nerve Degeneration-bring-Paralysis', 'Nerve Degeneration-bring-Death', 'Drug-Related Side Effects and Adverse Reactions-based-Diabetes Mellitus', 'Drug-Related Side Effects and Adverse Reactions-based-Cardiovascular Diseases', 'Drug-Related Side Effects and Adverse Reactions-exposed-Fractures, Bone', 'Stomach Ulcer-decrease-Ischemia', 'Stomach Ulcer-reduce-Stroke', 'Stomach Ulcer-reverse-Inflammation', 'Ischemia-reverse-Inflammation', 'Stroke-reverse-Inflammation', 'Death-termed-Necrosis', 'Myocardial Infarction-follow-Heart Failure', 'Neoplasms-limited-Drug-Related Side Effects and Adverse Reactions', 'Kidney Neoplasms-vary-Death', 'Bone Neoplasms-vary-Death', 'Cystic Fibrosis-associate-Lung Diseases', 'Lung Diseases-associate-Cystic Fibrosis', 'Cardiovascular Diseases-suffer-Atherosclerosis', 'Atherosclerosis-confirmed-Acquired Immunodeficiency Syndrome', 'Myalgia-dilate-Heart Failure', 'Thalassemia-present-Anemia', 'Anemia-distinguished-Thalassemia', 'Heart Diseases-develop-Heart Failure', 'Neoplasms-came-Stomach Neoplasms', 'Acromegaly-account-Death', 'Death-attributed-End Stage Liver Disease', 'Polycystic Ovary Syndrome-characterised-Hyperandrogenism', 'Obesity-characterised-Hyperandrogenism', 'Obesity-represent-Hyperandrogenism', 'Obesity-affect-Polycystic Ovary Syndrome', 'Metabolic Syndrome-affect-Polycystic Ovary Syndrome', 'Mevalonate Kinase Deficiency-develop-Nervous System Diseases', 'Alzheimer Disease-revealed-Motor Neuron Disease', 'Pain-reported-Parkinson Disease', 'Pain-reported-Parkinsonian Disorders', 'Death-needed-Heart Diseases', 'Death-needed-Liver Diseases', 'Pancreatic Neoplasms-result-Drug-Related Side Effects and Adverse Reactions', 'Pancreatic Neoplasms-result-Neoplasms', 'Adrenal Insufficiency-associated-Friedreich Ataxia', 'Friedreich Ataxia-associated-Adrenal Insufficiency', 'Glioblastoma-treated-Tinea Capitis', 'Anemia, Sickle Cell-provide-Pain', 'Fibrosis-show-Hypotension', 'Renal Insufficiency-associated-End Stage Liver Disease', 'End Stage Liver Disease-associated-Renal Insufficiency', 'Renal Insufficiency-associated-Infections', 'Infections-associated-Renal Insufficiency', 'Renal Insufficiency-associated-Hemorrhage', 'Hemorrhage-associated-Renal Insufficiency', 'Metabolic Diseases-associated-Fibrosis', 'Fibrosis-associated-Metabolic Diseases', 'Amyotrophic Lateral Sclerosis-result-Paralysis', 'Meningitis, Bacterial-considered-Kidney Diseases', 'Ascites-considered-Kidney Diseases', 'Kidney Diseases-caused-Infections', 'Classical Lissencephalies and Subcortical Band Heterotopias-include-Lissencephaly', 'Classical Lissencephalies and Subcortical Band Heterotopias-include-Intellectual Disability', 'Multiple Sclerosis-improve-Nervous System Diseases', 'Multiple Sclerosis-tolerated-Nausea', 'Multiple Sclerosis-tolerated-Menstruation Disturbances', 'Multiple Sclerosis-tolerated-Infections', 'Nausea-tolerated-Menstruation Disturbances', 'Nausea-tolerated-Infections', 'Choroidal Neovascularization-carry-Vision Disorders', 'Cerebellar Diseases-associated-Agenesis of Corpus Callosum', 'Agenesis of Corpus Callosum-associated-Cerebellar Diseases', 'Sialic Acid Storage Disease-demonstrated-Hypothalamic Neoplasms', 'HIV Infections-include-Vision Disorders', 'Vision Disorders-include-Retinitis', 'Vision Disorders-include-Ischemia', 'Vision Disorders-include-Tuberculosis, Ocular', 'Vision Disorders-include-Meningitis, Cryptococcal', 'Vision Disorders-include-Drug Hypersensitivity', 'Retinitis-include-HIV Infections', 'Ischemia-include-HIV Infections', 'Ischemia-related-HIV Infections', 'Tuberculosis, Ocular-include-HIV Infections', 'Blindness-related-HIV Infections', 'Meningitis, Cryptococcal-include-HIV Infections', 'Blindness-related-Acquired Immunodeficiency Syndrome', 'Drug Hypersensitivity-include-HIV Infections', 'Pain-precede-Exanthema', 'Retinitis-include-Acquired Immunodeficiency Syndrome', 'Ischemia-include-Acquired Immunodeficiency Syndrome', 'Tuberculosis, Ocular-include-Acquired Immunodeficiency Syndrome', 'Meningitis, Cryptococcal-include-Acquired Immunodeficiency Syndrome', 'Drug Hypersensitivity-include-Acquired Immunodeficiency Syndrome', 'Neuralgia-persist-Pain', 'Osteoporotic Fractures-concern-Fractures, Bone', 'Kidney Failure, Chronic-treated-Death', 'Papillomavirus Infections-used-Neoplasms', 'Cardiovascular Diseases-cause-Renal Insufficiency', 'Lung Diseases-offered-Hypertension, Pulmonary', 'Death-reversed-Acquired Immunodeficiency Syndrome', 'Bone Neoplasms-confuse-Periodontitis', 'Cardiomyopathy, Hypertrophic-contribute-Death', 'Cardiomyopathy, Hypertrophic-observed-Acromegaly', 'Heart Diseases-observed-Acromegaly', 'Shock, Cardiogenic-succumb-Pulmonary Embolism', 'Neoplasms-account-Hearing Loss', 'Cardiomyopathies-performed-Neoplasms', 'Infertility, Female-used-Heart Failure', 'Neoplasms-treated-Skin Neoplasms', 'Death-caused-Carcinoma, Hepatocellular', 'Hemochromatosis-caused-Carcinoma, Hepatocellular', 'Thalassemia-remain-Heart Failure', 'Thalassemia-remain-Arrhythmias, Cardiac', 'Arrhythmias, Cardiac-remain-Death', 'Prostatic Hyperplasia-continue-Death', 'Tricuspid Atresia-separate-Stenosis, Pulmonary Artery', 'Osteosarcoma-modify-Neoplasms', 'Rhabdomyosarcoma-modify-Neoplasms', 'Sarcoma-modify-Neoplasms', 'Neoplasms-influenced-Pituitary Neoplasms', 'Aortic Aneurysm, Abdominal-repaired-Death', 'Neoplasms-range-Drug-Related Side Effects and Adverse Reactions', 'Neoplasms-range-Hypotension', 'Drug-Related Side Effects and Adverse Reactions-range-Hypotension', 'Endometriosis-experience-Dystonia', 'Endometriosis-experience-Dysmenorrhea', 'Endometriosis-experience-Infertility, Female', 'Inflammation-contribute-Endometriosis', 'Biliary Dyskinesia-lead-Fibrosis', 'Ovarian Diseases-derive-Endometriosis', 'Neoplasms-linked-Obesity', 'Neoplasms-connected-Obesity', 'Obesity-connected-Neoplasms', 'Obesity-connected-Death', 'Vision Disorders-improve-Hypopituitarism', 'Polyendocrinopathies, Autoimmune-assess-HIV Infections', 'Polyendocrinopathies, Autoimmune-associated-Alzheimer Disease', 'Alzheimer Disease-associated-Polyendocrinopathies, Autoimmune', 'Foot Ulcer-found-Hypesthesia', 'Diabetes Mellitus-divide-Albuminuria', 'Death-recommended-Coronary Artery Disease', 'Death-lower-Coronary Artery Disease', 'Obesity-promote-Infections', 'Metabolic Diseases-associated-Hypothalamic Neoplasms', 'Hypothalamic Neoplasms-associated-Metabolic Diseases', 'Hypothalamic Diseases-reach-Craniopharyngioma', 'Craniopharyngioma-reach-Neoplasms', 'Hypothalamic Diseases-include-Obesity', 'Hypothalamic Diseases-occur-Obesity', 'Parkinson Disease, Secondary-reduce-Death', 'Pancreatic Neoplasms-positioned-Death', 'Pancreatic Neoplasms-positioned-Lung Neoplasms', 'Gaucher Disease-show-Movement Disorders', 'Pneumonia-arouse-Lung Diseases', 'Parvoviridae Infections-investigated-Anemia', 'Parvoviridae Infections-suffer-Anemia', 'Parvoviridae Infections-investigated-Pancytopenia', 'Parvoviridae Infections-suffer-Pancytopenia', 'Death-control-Hemorrhage', 'Malnutrition-reduce-Death', 'Brain Death-consist-Nervous System Diseases', 'Brain Death-consist-Alzheimer Disease', 'Infections-declining-Stomach Neoplasms', 'Brain Death-compare-Death', 'Death-compare-Brain Death', 'Neoplasms-compare-Brain Death', 'HIV Infections-decrease-Inflammation', 'Prostatic Neoplasms-exacerbate-Metabolic Syndrome', 'Prostatic Neoplasms-exacerbate-Heart Diseases', 'Epilepsy-exhibit-Seizures', 'Epilepsy-exhibit-Movement Disorders', 'Drug-Related Side Effects and Adverse Reactions-include-Nervous System Diseases', 'Tremor-exhibit-Hyperkinesis', 'Tremor-exhibit-Seizures', 'Sarcopenia-associated-Cardiomyopathies', 'Cardiomyopathies-associated-Sarcopenia', 'Sarcopenia-lead-Cardiomyopathies', 'Achondroplasia-understand-Growth Disorders', 'Chronic Disease-attribute-Death', 'Chronic Disease-attribute-Cardiovascular Diseases', 'Death-attribute-Cardiovascular Diseases', 'Edema-decrease-Ascites', 'Parkinson Disease, Secondary-characterised-Weight Loss', 'Parkinson Disease, Secondary-characterised-Hypoventilation', 'Neurodegenerative Diseases-characterised-Parkinson Disease, Secondary', 'Neurodegenerative Diseases-characterised-Weight Loss', 'Neurodegenerative Diseases-characterised-Hypoventilation', 'Renal Insufficiency, Chronic-play-Erectile Dysfunction', 'Parkinson Disease, Secondary-came-Death', 'Erectile Dysfunction-consider-Renal Insufficiency, Chronic', 'Mesenteric Vascular Occlusion-thought-Blindness', 'Epilepsy-arise-Seizures', 'Epilepsy-exist-Seizures', 'Intracranial Hemorrhages-lost-Cerebral Infarction', 'Intracranial Hemorrhages-weight-Cerebral Infarction', 'Rheumatic Diseases-develop-HIV Infections', 'Rheumatic Diseases-lead-Pain', 'Rheumatic Diseases-lead-Dystonia', 'Peripheral Nervous System Diseases-develop-HIV Infections', 'Peripheral Nervous System Diseases-develop-Dystonia', 'HIV Infections-develop-Pain', 'HIV Infections-develop-Dystonia', 'HIV Infections-lead-Muscle Weakness', 'Atrial Fibrillation-lessen-Arrhythmias, Cardiac', 'Atrial Fibrillation-demonstrate-Thrombosis', 'Mucocutaneous Lymph Node Syndrome-associated-Myocardial Infarction', 'Myocardial Infarction-associated-Mucocutaneous Lymph Node Syndrome', 'Coronary Aneurysm-associated-Myocardial Infarction', 'Myocardial Infarction-associated-Coronary Aneurysm', 'Chronic Disease-reduced-Cardiovascular Diseases', 'Chronic Disease-reduced-Metabolic Syndrome', 'Neoplasms-define-Multiple Organ Failure', 'Neoplasms-occur-Malocclusion', 'Eye Abnormalities-related-Shy-Drager Syndrome', 'Hypertension, Pulmonary-diagnosed-Lung Diseases, Interstitial', 'Eye Abnormalities-confirm-Shy-Drager Syndrome', 'Nervous System Malformations-associated-Osteomyelitis', 'Osteomyelitis-associated-Nervous System Malformations', 'Back Pain-associated-Osteomyelitis', 'Osteomyelitis-associated-Back Pain', 'Heart Arrest-induce-Leukemia, Myeloid, Acute', 'Leukemia, Myeloid, Acute-reduce-Neoplasms', 'Neoplasms-required-Prostatic Neoplasms', 'Pain-include-Neoplasm Metastasis', 'Hypercalcemia-include-Neoplasm Metastasis', 'Fractures, Bone-include-Neoplasm Metastasis', 'Cachexia-include-Neoplasm Metastasis', 'Death-suffer-Neoplasm Metastasis', 'Neoplasms-use-Carcinoma, Hepatocellular', 'Pain-emerge-Motor Neuron Disease', 'Pain-emerge-Parkinson Disease', 'Hemophilia A-associated-Hypertension', 'Hypertension-associated-Hemophilia A', 'Lysosomal Storage Diseases-include-Tauopathies', 'Carcinoma, Squamous Cell-account-Neoplasms', 'Wounds and Injuries-result-Brain Injuries, Traumatic', 'Wounds and Injuries-result-Splenic Diseases', 'Epilepsy-account-Brain Injuries, Traumatic', 'Neurodegenerative Diseases-characterized-Muscle Weakness', 'Abdominal Pain-related-Hemolysis', 'Renal Insufficiency-related-Hemolysis', 'Hypertension, Pulmonary-related-Hemolysis', 'Thrombophilia-related-Hemolysis', 'Sepsis-prevent-Immunologic Deficiency Syndromes', 'Thrombophilia-include-Hemoglobinuria, Paroxysmal', 'Diabetes Mellitus-confined-Kidney Diseases', 'Meningeal Neoplasms-present-Neoplasms', 'Hemorrhage-related-Head and Neck Neoplasms', 'Death-doubled-HIV Infections', 'Fanconi Syndrome-include-Cystinosis', 'Death-cause-Seizures', 'Death-cause-Pneumonia, Aspiration', 'Death-cause-Sepsis', 'Death-driven-Sepsis', 'Death-driven-Stroke', 'Immunologic Deficiency Syndromes-treat-Drug Hypersensitivity', 'Language Disorders-minimize-Neoplasms', 'Immunologic Deficiency Syndromes-treat-Inflammation', 'Death-affected-Hemophilia A', 'Neoplasms-affected-Hemophilia A', 'Neoplasm Metastasis-improve-Small Cell Lung Carcinoma', 'Neoplasm Metastasis-reduce-Small Cell Lung Carcinoma', 'Hemorrhage-highlighted-Bone Marrow Diseases', 'Brain Injuries, Traumatic-recognized-Hypopituitarism', 'Craniocerebral Trauma-discuss-Hypopituitarism', 'Papillomavirus Infections-combine-Neoplasms', 'Abnormalities, Drug-Induced-known-Fetal Alcohol Spectrum Disorders', 'Cardiomyopathy, Hypertrophic-thought-Communicable Diseases', 'Fibrosis-assess-Hypertension', 'Death-elevated-Communicable Diseases', 'Death-elevated-HIV Infections', 'Death-elevated-Acquired Immunodeficiency Syndrome', 'Acquired Immunodeficiency Syndrome-include-Death', 'Seminoma-decrease-Drug-Related Side Effects and Adverse Reactions', 'HIV Infections-include-Communicable Diseases', 'Kidney Diseases-define-Renal Insufficiency, Chronic', 'Death-related-Cystic Fibrosis', 'Prostatic Neoplasms-identify-Death', 'Liver Diseases-include-Cystic Fibrosis', 'Necrosis-present-Marfan Syndrome', 'Arrhythmogenic Right Ventricular Dysplasia-associated-Death', 'Death-associated-Arrhythmogenic Right Ventricular Dysplasia', 'Aortic Valve Insufficiency-prevent-Aneurysm', 'Arrhythmogenic Right Ventricular Dysplasia-associated-HIV Infections', 'HIV Infections-associated-Arrhythmogenic Right Ventricular Dysplasia', 'Aortic Valve Insufficiency-prevent-Rupture', 'Arrhythmogenic Right Ventricular Dysplasia-associated-Acquired Immunodeficiency Syndrome', 'Acquired Immunodeficiency Syndrome-associated-Arrhythmogenic Right Ventricular Dysplasia', 'Neurilemmoma-lead-Hearing Loss', 'Neurilemmoma-lead-Deafness', 'Hearing Loss-precede-Tinnitus', 'Amyotrophic Lateral Sclerosis-characterized-Retinal Degeneration', 'Amyotrophic Lateral Sclerosis-result-Respiratory Paralysis', 'Neurodegenerative Diseases-characterized-Retinal Degeneration', 'Neurodegenerative Diseases-result-Respiratory Paralysis', 'Retinal Degeneration-result-Respiratory Paralysis', 'Retinal Degeneration-result-Death', 'Cholangitis, Sclerosing-diagnosed-Adenomatosis, Pulmonary', 'Celiac Disease-noted-Diabetes Mellitus', 'Celiac Disease-noted-Thyroiditis, Autoimmune', 'Celiac Disease-noted-Liver Cirrhosis, Biliary', 'Autoimmune Diseases-found-Celiac Disease', 'Celiac Disease-found-Thyroiditis, Autoimmune', 'Celiac Disease-found-Diabetes Mellitus, Type 1', 'Celiac Disease-found-Liver Diseases', 'Celiac Disease-found-Inflammatory Bowel Diseases', 'Diabetes Mellitus-enhance-Hypothyroidism', 'Diabetes Mellitus-enhance-Osteoporosis', 'Dysplastic Nevus Syndrome-diagnosed-Carcinoma, Squamous Cell', 'Obesity-linked-Sexual Dysfunction, Physiological', 'Lung Diseases-outlive-Cystic Fibrosis', 'Acquired Immunodeficiency Syndrome-prevent-HIV Infections', 'Acquired Immunodeficiency Syndrome-associate-Death', 'Death-associate-Acquired Immunodeficiency Syndrome', 'HIV Infections-prevent-Death', 'Leishmaniasis-emerge-Opportunistic Infections', 'Infections-refer-Infertility, Female', 'Polycythemia Vera-suspected-Splenomegaly', 'Polycythemia Vera-suspected-Venous Thrombosis', 'Liver Neoplasms-characterized-Muscular Atrophy', 'Neurodegenerative Diseases-characterized-Muscular Atrophy', 'Spinal Cord Injuries-develop-Prostatic Neoplasms', 'Stroke-report-Intracranial Hemorrhages', 'Cerebral Infarction-underlie-Stroke', 'Intracranial Arteriosclerosis-underlie-Stroke', 'Cerebral Small Vessel Diseases-underlie-Stroke', 'Hypertension-resolve-Diabetes Mellitus', 'Weight Loss-correct-Diabetes Mellitus', 'Weight Loss-correct-Hypertension', 'Obesity-prevent-Hypertension', 'Treponemal Infections-indicate-Tuberculosis', 'Diabetes Mellitus-account-Cardiovascular Diseases', 'Mucopolysaccharidosis VII-associated-Hearing Loss, Central', 'Hearing Loss, Central-associated-Mucopolysaccharidosis VII', 'Mucopolysaccharidosis VII-associated-Hearing Loss', 'Hearing Loss-associated-Mucopolysaccharidosis VII', 'Mucopolysaccharidosis VII-associated-Vision, Low', 'Vision, Low-associated-Mucopolysaccharidosis VII', 'Liver Diseases-established-Fibrosis', 'Mucopolysaccharidosis VII-associated-Intellectual Disability', 'Intellectual Disability-associated-Mucopolysaccharidosis VII', 'Fibrosis-fall-Blood Coagulation Disorders', 'Bile Reflux-stimulate-Fibrosis', 'Cholecystitis-include-Fatty Liver', 'Genetic Diseases, X-Linked-characterised-Renal Insufficiency', 'Genetic Diseases, X-Linked-characterised-Cerebrovascular Disorders', 'Renal Insufficiency-characterised-Cerebrovascular Disorders', 'Neoplasms-base-Genetic Diseases, Inborn', 'Neoplasms-block-Genetic Diseases, Inborn', 'Peripheral Nervous System Diseases-associated-Death', 'Death-associated-Peripheral Nervous System Diseases', 'Ascites-defined-Hemolytic-Uremic Syndrome', 'Death-related-Prostatic Neoplasms', 'Neoplasm Metastasis-imply-Pain', 'Heart Failure-taken-Hypertension', 'Cardiomyopathy, Hypertrophic-taken-Hypertension', 'Stroke-precede-Cough', 'Ischemia-associated-Aneurysm', 'Aneurysm-associated-Ischemia', 'Foramen Ovale, Patent-associated-Aneurysm', 'Aneurysm-associated-Foramen Ovale, Patent', 'Aneurysm-associated-Cough', 'Cough-associated-Aneurysm', 'Foramen Ovale, Patent-considered-Embolism, Paradoxical', 'Wounds and Injuries-improve-Death', 'Wounds and Injuries-improve-Airway Obstruction', 'Wounds and Injuries-improve-Hemorrhage', 'Wounds and Injuries-improve-Pneumothorax', 'Fever-include-Pneumothorax', 'Prostatic Neoplasms-benefit-Neoplasms', 'Neoplasms-minimize-Death', 'Carcinoma, Hepatocellular-include-Hypersensitivity, Immediate', 'Multiple Myeloma-examined-Kidney Diseases', 'Renal Insufficiency-examined-Kidney Diseases', 'Neoplasms-stimulate-Fibrosarcoma', 'Diabetes Mellitus, Type 1-follow-Death', 'Neoplasms-stimulate-Adenoma', 'Proteinuria-develop-Death', 'Genetic Diseases, X-Linked-exhibit-Necrosis', 'Intellectual Disability-accelerate-Death', 'Intellectual Disability-accelerate-Hemolysis', 'Diabetes Mellitus-constitute-Huntington Disease', 'Vision Disorders-identified-Anophthalmos', 'Neurologic Manifestations-contribute-Fibrosis', 'Obesity-induce-Malnutrition', 'Pulmonary Disease, Chronic Obstructive-afflict-Death', 'Pulmonary Disease, Chronic Obstructive-afflict-Respiratory Tract Diseases', 'Death-listed-Neoplasms', 'Obesity-confer-Communicable Diseases', 'Neoplasms-differ-Leukemia', 'Neoplasms-differ-Lymphoma', 'Death-outperform-Coronary Artery Disease', 'Death-outperform-Fatty Liver', 'Amyotrophic Lateral Sclerosis-include-Genetic Diseases, Inborn', 'Weight Gain-include-HIV Infections', 'Diabetes Mellitus-associate-Insulin Resistance', 'Insulin Resistance-associate-Diabetes Mellitus', 'Obesity-prevent-Ventricular Remodeling', 'Pneumonia-defined-Leukocytosis', 'Cholangiocarcinoma-include-Neoplasms', 'Neoplasms-struggle-Death', 'Tooth, Impacted-impact-Neoplasms', 'Death-occur-Nervous System Diseases', 'Eunuchism-associated-Obesity', 'Obesity-associated-Eunuchism', 'Eunuchism-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-Eunuchism', 'Wounds and Injuries-buffer-Pain', 'Pain-mediate-Wounds and Injuries', 'Heart Failure-followed-Anemia', 'Ovarian Neoplasms-evaluate-Growth Disorders', 'Anemia-explore-Death', 'Anemia-explore-Heart Failure', 'Anemia-explore-Hemorrhage', 'Death-explore-Hemorrhage', 'Heart Failure-explore-Hemorrhage', 'Cardiovascular Diseases-compare-Hemophilia A', 'Cardiovascular Diseases-capped-Diabetes Mellitus', 'Neurodegenerative Diseases-cause-Nerve Degeneration', 'Neurodegenerative Diseases-lead-Respiratory Insufficiency', 'Nerve Degeneration-lead-Respiratory Insufficiency', 'Neoplasms-use-Paranasal Sinus Neoplasms', 'Pneumococcal Infections-include-Communicable Diseases', 'Anemia, Sickle Cell-found-Cerebral Infarction', 'Death-determined-Emphysema', 'Critical Illness-cause-Ulcer', 'Critical Illness-cause-Chronic Pain', 'Peripheral Arterial Disease-cause-Ulcer', 'Peripheral Arterial Disease-cause-Chronic Pain', 'Hyperacusis-sounds-Pain', 'Carcinogenesis-use-Carcinoma, Pancreatic Ductal', 'Pancreatic Neoplasms-associated-Jaundice, Obstructive', 'Jaundice, Obstructive-associated-Pancreatic Neoplasms', 'Death-associated-Jaundice, Obstructive', 'Jaundice, Obstructive-associated-Death', 'Osteoporotic Fractures-diagnose-Osteoporosis', 'Pancreatic Neoplasms-improve-Biliary Dyskinesia', 'Jaundice, Obstructive-associated-Biliary Dyskinesia', 'Biliary Dyskinesia-associated-Jaundice, Obstructive', 'Infections-require-Adrenal Insufficiency', 'Neurotoxicity Syndromes-induce-Drug-Related Side Effects and Adverse Reactions', 'Neurotoxicity Syndromes-induce-Parkinson Disease', 'Drug-Related Side Effects and Adverse Reactions-include-Parkinson Disease', 'Fractures, Bone-incorporated-Osteoporosis', 'Neurotoxicity Syndromes-use-Parkinson Disease', 'Infections-suffer-Anemia', 'Anemia-suffer-Stroke', 'Anemia-suffer-Kidney Diseases', 'Stroke-affect-Death', 'Chronic Disease-promise-HIV Infections', 'Pain-reduce-Death', 'AIDS Arteritis, Central Nervous System-consist-HIV Infections', 'Immunologic Deficiency Syndromes-cause-Metabolic Diseases', 'Polycystic Ovary Syndrome-incorporate-Oligomenorrhea', 'Polycystic Ovary Syndrome-incorporate-Hirsutism', 'Chemical and Drug Induced Liver Injury-lead-Non-alcoholic Fatty Liver Disease', 'Vision Disorders-followed-Epilepsy', 'Heart Arrest-considered-Heart Block', 'Epilepsy-belong-Epilepsies, Partial', 'Colorectal Neoplasms-over-express-Neoplasms', 'Fibrosis-lead-Multiple Organ Failure', 'Alstrom Syndrome-lead-Multiple Organ Failure', 'Genetic Diseases, Inborn-associated-Dwarfism, Pituitary', 'Dwarfism, Pituitary-associated-Genetic Diseases, Inborn', 'Alstrom Syndrome-associated-Fibrosis', 'Fibrosis-associated-Alstrom Syndrome', 'Cardiotoxicity-mediate-Renal Insufficiency, Chronic', 'Alstrom Syndrome-associated-Death', 'Death-associated-Alstrom Syndrome', 'Hydronephrosis-complicated-Edema', 'Heart Failure-calculate-Renal Insufficiency', 'Dehydration-calculate-Renal Insufficiency', 'Neoplasms-calculate-Renal Insufficiency', 'Weight Loss-calculate-Renal Insufficiency', 'Dyspnea-calculate-Renal Insufficiency', 'Spinal Cord Injuries-preclude-Infections', 'Spinal Cord Injuries-preclude-Inflammation', 'Leukodystrophy, Globoid Cell-target-Central Nervous System Diseases', 'Leukodystrophy, Globoid Cell-result-Demyelinating Diseases', 'Leukodystrophy, Globoid Cell-result-Death', 'Alzheimer Disease-characterized-Learning Disabilities', 'Autoimmune Diseases-result-Lupus Erythematosus, Systemic', 'Lupus Erythematosus, Systemic-made-Klinefelter Syndrome', 'Musculoskeletal Pain-reported-HIV Infections', 'Musculoskeletal Pain-develop-Rheumatic Diseases', 'HIV Infections-develop-Rheumatic Diseases', 'Inflammatory Bowel Diseases-compared-Cholangitis, Sclerosing', 'Liver Diseases-compared-Cholangitis, Sclerosing', 'Hypertension-decrease-Kidney Diseases', 'Inflammatory Bowel Diseases-impact-Cholangitis, Sclerosing', 'Liver Diseases-impact-Cholangitis, Sclerosing', 'Sleep Initiation and Maintenance Disorders-accumulate-Brain Neoplasms', 'Lymphoma-induce-Death', 'Death-guide-Neoplasms', 'Congenital Abnormalities-reveal-Nephrolithiasis', 'Arthritis, Psoriatic-affect-Psoriasis', 'Autoimmune Diseases-affect-Psoriasis', 'Arthritis, Psoriatic-develop-Psoriasis', 'Wounds and Injuries-associated-Substance-Related Disorders', 'Substance-Related Disorders-associated-Wounds and Injuries', 'Cystic Fibrosis-shorten-Airway Obstruction', 'Cystic Fibrosis-shorten-Infections', 'Cystic Fibrosis-shorten-Respiratory Insufficiency', 'Death-related-Multiple Sclerosis', 'Breast Neoplasms-reflect-Obesity', 'Endometrial Neoplasms-increase-Obesity', 'Cystic Fibrosis-recovered-Respiratory Tract Infections', 'Respiratory Tract Infections-increase-Cystic Fibrosis', 'Leukodystrophy, Globoid Cell-result-Nervous System Malformations', 'Leukodystrophy, Metachromatic-result-Nervous System Malformations', 'Cystic Fibrosis-suffer-Bacterial Infections', 'Obesity-aggravate-Kidney Diseases', 'Cardiovascular Diseases-shown-Kidney Diseases', 'Obesity-aggravate-Glomerulonephritis', 'Stroke-shown-Kidney Diseases', 'Coronary Artery Disease-shown-Kidney Diseases', 'Obesity-impair-Kidney Diseases', 'Proteinuria-associated-Obesity', 'Obesity-associated-Proteinuria', 'Albuminuria-make-Kidney Diseases', 'Essential Tremor-characterized-Thrombosis', 'Essential Tremor-characterized-Hemorrhage', 'Neoplasms-characterized-Thrombosis', 'Neoplasms-characterized-Hemorrhage', 'Primary Immunodeficiency Diseases-characterised-Infections', 'Adenomatous Polyposis Coli-accelerate-Death', 'Adenomatous Polyposis Coli-promote-Adenoma', 'Death-promote-Adenoma', 'Central Nervous System Neoplasms-bring-Drug-Related Side Effects and Adverse Reactions', 'Glioma-defer-Neoplasms', 'Muscular Diseases-attributed-Mitochondrial Diseases', 'Abnormalities, Drug-Induced-attributed-Mitochondrial Diseases', 'Death-customize-Neoplasms', 'Colorectal Neoplasms-approach-Neoplasms', 'Obesity-take-Hypothalamic Neoplasms', 'Urinary Bladder Neoplasms-result-Neoplasms', 'Death-remain-Cardiomyopathies', 'Hypothalamic Neoplasms-result-Weight Loss', 'Pelvic Floor Disorders-screen-Fractures, Stress', 'Death-increase-Breast Neoplasms', 'Atrial Fibrillation-estimate-Stroke', 'Neoplasm Metastasis-base-Neoplasms', 'Death-related-Esophageal Achalasia', 'Dwarfism, Pituitary-suffer-Heart Failure', 'Cardiovascular Diseases-made-Death', 'Aortic Valve Insufficiency-include-Death', 'Aortic Aneurysm-include-Death', 'Cardiomyopathy, Dilated-include-Death', 'Mitral Valve Prolapse-include-Death', 'Gastrointestinal Diseases-considered-Stomach Neoplasms', 'Hallucinations-caused-Opportunistic Infections', 'Hallucinations-considered-Stomach Neoplasms', 'HIV Infections-considered-Stomach Neoplasms', 'Opportunistic Infections-considered-Stomach Neoplasms', 'Sarcoma, Kaposi-considered-Stomach Neoplasms', 'Lymphoma-considered-Stomach Neoplasms', 'Asthma-related-Carcinoma', 'Epilepsy-antedate-Seizures', 'Epileptic Syndromes-antedate-Seizures', 'Cardiovascular Diseases-rank-Death', 'Weight Gain-associated-Obstetric Labor, Premature', 'Obstetric Labor, Premature-associated-Weight Gain', 'Weight Gain-associated-Nausea', 'Nausea-associated-Weight Gain', 'Alzheimer Disease-slow-Nerve Degeneration', 'Sleep Disorders, Circadian Rhythm-present-Neoplasms', 'Walker-Warburg Syndrome-characterized-Central Nervous System Diseases', 'Muscular Dystrophies-characterized-Central Nervous System Diseases', 'Atherosclerosis-driven-Arthritis, Rheumatoid', 'Nijmegen Breakage Syndrome-characterized-Growth Disorders', 'Nijmegen Breakage Syndrome-characterized-Microcephaly', 'Nijmegen Breakage Syndrome-characterized-Immunologic Deficiency Syndromes', 'Chromosomal Instability-characterized-Growth Disorders', 'Chromosomal Instability-characterized-Microcephaly', 'Seizures-cause-Brain Injuries', 'Chromosomal Instability-characterized-Immunologic Deficiency Syndromes', 'Seizures-include-Nerve Degeneration', 'Seizures-cause-Nerve Degeneration', 'Nerve Degeneration-include-Brain Injuries', 'Epilepsy-relate-Seizures', 'Death-minimize-Diabetes Mellitus', 'Death-attributed-Malaria', 'Respiratory Tract Diseases-account-Pneumonia', 'Lung Diseases-account-Pneumonia', 'Classical Lissencephalies and Subcortical Band Heterotopias-result-Epilepsy', 'Classical Lissencephalies and Subcortical Band Heterotopias-result-Intellectual Disability', 'Classical Lissencephalies and Subcortical Band Heterotopias-result-Malformations of Cortical Development', 'Osteoarthritis-focus-Death', 'Osteoarthritis-predict-Cardiovascular Diseases', 'Paralysis-result-Voice Disorders', 'Carcinoma, Hepatocellular-associated-Liver Cirrhosis, Biliary', 'Liver Cirrhosis, Biliary-associated-Carcinoma, Hepatocellular', 'Death-estimated-Liver Cirrhosis, Biliary', 'Carcinoma, Hepatocellular-develop-Liver Cirrhosis, Biliary', 'Death-reported-Infections', 'Death-reported-Vasculitis', 'Death-reported-Amyloidosis', 'Edema-become-Breast Neoplasms', 'Fractures, Spontaneous-offer-Neoplasms', 'Glioblastoma-inoculated-Brain Neoplasms', 'Glioblastoma-establish-Brain Neoplasms', 'Neoplasms-include-Osteosarcoma', 'Adenoma-remove-Colorectal Neoplasms', 'Adenoma-reduce-Colorectal Neoplasms', 'Cardiovascular Diseases-exceed-Neoplasms', 'Cardiovascular Diseases-eliminate-Neoplasms', 'Respiratory Tract Diseases-eliminate-Neoplasms', 'Neoplasms-compare-Ascites', 'Bone Marrow Diseases-result-Fever', 'Fever-result-Drug-Related Side Effects and Adverse Reactions', 'Lymphoma-affected-Leukemia, Myeloid, Acute', 'Lymphoma-affected-Myelodysplastic Syndromes', 'Meningeal Neoplasms-occur-Neoplasms', 'Neoplasm Metastasis-develop-Meningeal Neoplasms', 'Meningeal Neoplasms-result-Mastocytosis, Systemic', 'Osteoblastoma-considered-Neoplasms', 'Neoplasms-become-Neoplasm Metastasis', 'Osteoblastoma-show-Osteosarcoma', 'Osteoblastoma-show-Neoplasms', 'Osteosarcoma-show-Neoplasms', 'Neutropenia-include-Drug-Related Side Effects and Adverse Reactions', 'Death-observed-Coronary Artery Disease', 'Neoplasms-enter-Carcinoma, Squamous Cell', 'Death, Sudden-include-LEOPARD Syndrome', 'Heart Diseases-include-LEOPARD Syndrome', 'Muscular Diseases-include-LEOPARD Syndrome', 'Cardiomyopathy, Hypertrophic-reviewed-Hypertrophy', 'Stomach Neoplasms-result-Death', 'Cardiomyopathy, Hypertrophic-hitherto-Inflammatory Bowel Diseases', 'Death-accounted-Neoplasms', 'Death-accounted-Respiratory Tract Diseases', 'Death-accounted-Aneurysm', 'Prostatic Neoplasms-suggest-Neoplasms', 'Arthritis, Rheumatoid-associated-Arthritis', 'Arthritis-associated-Arthritis, Rheumatoid', 'Splenomegaly-compare-Leukemia, Lymphoid', 'Leukemia-compare-Leukemia, Lymphoid', 'Neoplasm Metastasis-develop-Muscle Weakness', 'Anemia-cause-Disseminated Intravascular Coagulation', 'Death-account-Chemical and Drug Induced Liver Injury', 'Myelodysplastic Syndromes-reveal-Primary Myelofibrosis', 'Hyperplasia-increase-Primary Myelofibrosis', 'Disseminated Intravascular Coagulation-contribute-Thrombocytopenia', 'Lacrimal Apparatus Diseases-inoculated-Glioblastoma', 'Hypertension-diagnosed-Hypotension', 'Liver Failure-include-Liver Diseases', 'Liver Cirrhosis-include-Liver Diseases', 'Ischemia-include-Liver Diseases', 'Reperfusion Injury-include-Liver Diseases', 'Hypertension-last-Coronary Artery Disease', 'Hypertension-last-Myocardial Infarction', 'Hypertension-last-Stroke', 'Osteoporotic Fractures-registered-Fractures, Bone', 'Cardiomyopathy, Dilated-treat-Ventricular Septal Rupture', 'Hypoplastic Left Heart Syndrome-treat-Ventricular Septal Rupture', 'Death-occur-Pancreatic Neoplasms', 'Death-occur-Infarction, Middle Cerebral Artery', 'Atrial Fibrillation-pose-Chronic Kidney Disease-Mineral and Bone Disorder', 'Neurologic Manifestations-trigger-Thromboembolism', 'Death-demonstrate-Neoplasms', 'Myocardial Infarction-result-Coronary Artery Disease', 'Metabolic Syndrome-mitigate-Obesity', 'Osteochondroma-cause-Musculoskeletal Diseases', 'Genetic Diseases, Inborn-cause-Primary Dysautonomias', 'Chronic Disease-co-exist-Metabolic Syndrome', 'Infections-improve-Cystic Fibrosis', 'Neoplasms-follow-Gastrointestinal Diseases', 'Cystic Fibrosis-characterised-Exocrine Pancreatic Insufficiency', 'Neoplasms-follow-Heredodegenerative Disorders, Nervous System', 'Cystic Fibrosis-characterised-Infertility, Male', 'Respiratory Tract Infections-characterised-Cystic Fibrosis', 'Inflammation-characterised-Cystic Fibrosis', 'Exocrine Pancreatic Insufficiency-characterised-Cystic Fibrosis', 'Infertility, Male-characterised-Cystic Fibrosis', 'Cardiovascular Diseases-characterized-Hypertension', 'Atrial Fibrillation-prevent-Fibrosis', 'Ossification of Posterior Longitudinal Ligament-caused-Lip Neoplasms', 'Death-seek-Diarrhea', 'Death-comprehend-HIV Infections', 'Gait Disorders, Neurologic-related-Pain', 'Gait Disorders, Neurologic-related-Chronic Pain', 'Muscular Dystrophy, Duchenne-diagnose-Muscular Diseases', 'Muscular Diseases-result-Death', 'Amyotrophic Lateral Sclerosis-suffer-Motor Neuron Disease', 'Death-attributed-Communicable Diseases', 'Amyotrophic Lateral Sclerosis-lead-Respiratory Insufficiency', 'Death-attributed-Idiopathic Pulmonary Fibrosis', 'Ulcer-increase-Infections', 'Respiratory Tract Diseases-attributed-Idiopathic Pulmonary Fibrosis', 'Obesity-relate-Heart Diseases', 'Pre-Eclampsia-increase-Stroke', 'Stillbirth-increase-Stroke', 'Vascular Remodeling-drive-Pulmonary Arterial Hypertension', 'Neurodegenerative Diseases-associated-Huntington Disease', 'Huntington Disease-associated-Neurodegenerative Diseases', 'Neoplasms-increased-Neoplasm Metastasis', 'Metabolic Syndrome-ascertained-Diabetes Mellitus', 'Metabolic Syndrome-correlated-Inflammation', 'Neoplasms-observe-Thymus Neoplasms', 'Neoplasms-observe-Lymphoma', 'Arthrogryposis-gain-Pain', 'Pain-experienced-Arthrogryposis', 'Arthrogryposis-undergone-Pain', 'Hypertension, Pulmonary-include-Idiopathic Pulmonary Fibrosis', 'Coronary Artery Disease-include-Idiopathic Pulmonary Fibrosis', 'Neoplasms-include-Idiopathic Pulmonary Fibrosis', 'Kidney Diseases-worsen-Renal Insufficiency, Chronic', 'Death-associate-Renal Insufficiency, Chronic', 'Renal Insufficiency, Chronic-associate-Death', 'Tachycardia, Ventricular-associated-Atrioventricular Block', 'Atrioventricular Block-associated-Tachycardia, Ventricular', 'Ventricular Dysfunction-associate-Tricuspid Valve Insufficiency', 'Tricuspid Valve Insufficiency-associate-Ventricular Dysfunction', 'Neoplasms-boost-Inflammation', 'Neoplasms-boost-Fibrosis', 'Carcinoma, Hepatocellular-involved-Neoplasms', 'Acute Coronary Syndrome-applied-Neoplasms', 'Neoplasms-observed-Acute Coronary Syndrome', 'Acute Coronary Syndrome-include-Neoplasms', 'Thrombocytopenia-include-Acute Coronary Syndrome', 'Atrial Fibrillation-include-Acute Coronary Syndrome', 'Venous Thromboembolism-include-Acute Coronary Syndrome', 'Hemorrhage-include-Acute Coronary Syndrome', 'Thrombocytopenia-related-Neoplasms', 'Atrial Fibrillation-include-Neoplasms', 'Hemorrhage-include-Neoplasms', 'Thrombocytopenia-needed-Atrial Fibrillation', 'Thrombocytopenia-needed-Venous Thromboembolism', 'Neoplasms-increase-Acute Coronary Syndrome', 'Pain-reverse-Chronic Disease', 'Hypertension, Pulmonary-known-Hemolysis', 'Hypertension, Pulmonary-known-Thrombophilia', 'Hypertension, Pulmonary-known-Hypoxia', 'Hypertension, Pulmonary-known-Reperfusion Injury', 'Psoriasis-experience-Inflammation', 'Anemia, Sickle Cell-contribute-Hemolysis', 'Anemia, Sickle Cell-contribute-Thrombophilia', 'Anemia, Sickle Cell-contribute-Hypoxia', 'Inflammation-precede-Thrombosis', 'Obesity-associated-Osteoarthritis, Hip', 'Osteoarthritis, Hip-associated-Obesity', 'Anemia, Sickle Cell-contribute-Reperfusion Injury', 'Inflammation-improve-Psoriasis', 'Sleep Wake Disorders-associated-Wounds and Injuries', 'Wounds and Injuries-associated-Sleep Wake Disorders', 'Cardiovascular Diseases-support-Diabetes Mellitus', 'Hematoma, Subdural-vary-Seizures', 'Bone Diseases-include-Inflammation', 'Bone Diseases-drive-Inflammation', 'Seizures-clarify-Brain Injuries, Traumatic', 'Seizures-include-Coma', 'Seizures-include-Intracranial Hemorrhages', 'Seizures-diagnosed-Brain Injuries, Traumatic', 'Seizures-include-Hypoxia', 'Seizures-worsen-Brain Injuries, Traumatic', 'Seizures-include-Hypotension', 'Seizures-include-Heart Arrest', 'Substance-Related Disorders-confer-Seizures', 'Hematoma, Subdural-confer-Seizures', 'Myalgia-cause-Muscular Dystrophy, Duchenne', 'Myalgia-affect-Genetic Diseases, X-Linked', 'Diabetes Mellitus-increase-Neoplasms', 'Death-investigate-Fractures, Bone', 'Acquired Immunodeficiency Syndrome-onset-Death', 'Acquired Immunodeficiency Syndrome-estimated-Death', 'Anemia, Sickle Cell-characterized-Anemia, Hemolytic', 'Death-related-Kidney Diseases', 'Death-investigate-Anemia, Sickle Cell', 'Death-use-Cerebrovascular Disorders', 'Death-calculated-Aneurysm', 'Death-use-Aneurysm', 'Adrenal Hyperplasia, Congenital-affected-Androgen-Insensitivity Syndrome', 'Adrenal Hyperplasia, Congenital-compare-Androgen-Insensitivity Syndrome', 'Infections-infect-Leishmaniasis', 'Heart Failure-recognized-Arthritis, Rheumatoid', 'Heart Failure-associated-Arthritis, Rheumatoid', 'Arthritis, Rheumatoid-associated-Heart Failure', 'Death-treated-Osteoporosis', 'Arthritis, Rheumatoid-exhibit-Cardiovascular Diseases', 'Arthritis, Rheumatoid-result-Death', 'Arthritis, Rheumatoid-associated-Ventricular Dysfunction, Left', 'Ventricular Dysfunction, Left-associated-Arthritis, Rheumatoid', 'Arthritis, Rheumatoid-associated-Hypotension', 'Hypotension-associated-Arthritis, Rheumatoid', 'Arthritis, Rheumatoid-lead-Hypotension', 'Ventricular Dysfunction, Left-lead-Hypotension', 'Sarcoma, Synovial-induce-Neoplasms', 'Rhabdomyosarcoma-induce-Neoplasms', 'Sarcoma, Kaposi-associated-Immunologic Deficiency Syndromes', 'Immunologic Deficiency Syndromes-associated-Sarcoma, Kaposi', 'Immunologic Deficiency Syndromes-associated-Hodgkin Disease', 'Hodgkin Disease-associated-Immunologic Deficiency Syndromes', 'Obesity-characterised-Death', 'Neoplasms-detect-Mediastinal Cyst', 'Ventricular Remodeling-occur-Alzheimer Disease', 'Ventricular Remodeling-occur-Huntington Disease', 'Huntington Disease-described-Heredodegenerative Disorders, Nervous System', 'Huntington Disease-lead-Heart Failure', 'Huntington Disease-exhibit-Death', 'Heredodegenerative Disorders, Nervous System-lead-Heart Failure', 'Heredodegenerative Disorders, Nervous System-exhibit-Death', 'Cardiomyopathies-related-Huntington Disease', 'Death-followed-Thrombocythemia, Essential', 'Thrombocythemia, Essential-reduced-Polycythemia Vera', 'Death-followed-Polycythemia Vera', 'Muscular Dystrophy, Duchenne-projected-Cardiomyopathies', 'Cardiomyopathies-increase-Death', 'Liver Cirrhosis-believed-Death', 'Cystic Fibrosis-become-Liver Diseases', 'Metabolism, Inborn Errors-underlie-Communicable Diseases', 'Psoriasis-associated-Atherosclerosis', 'Atherosclerosis-associated-Psoriasis', 'Retinoblastoma-inhibit-Neoplasms', 'Psoriasis-associated-Death', 'Death-associated-Psoriasis', 'Psoriasis-account-Death', 'Retinoblastoma-exhibit-Neoplasms', 'Retinoblastoma-exhibit-Death', 'Retinoblastoma-suppress-Neoplasms', 'Prostatic Neoplasms-base-Neoplasms', 'Prostatic Neoplasms-tailored-Neoplasms', 'Hip Fractures-lead-Pain', 'Hip Fractures-range-Delirium', 'Pain-range-Delirium', 'Brain Injuries, Traumatic-include-Pain', 'Delirium-range-Death', 'Obesity-lead-Metabolic Syndrome', 'Blindness-undergo-Retinal Diseases', 'Cataract-recognised-Glaucoma', 'Cataract-recognised-Refractive Errors', 'Inflammation-seen-Pulmonary Disease, Chronic Obstructive', 'Quadriplegia-remain-Respiratory Tract Diseases', 'Brain Neoplasms-multiforme-Glioblastoma', 'Neurologic Manifestations-contribute-Craniocerebral Trauma', 'Glioblastoma-characterized-Neoplasms', 'Venous Thrombosis-cause-Death', 'Neurodegenerative Diseases-suffer-Parkinson Disease', 'Breast Neoplasms-cause-Infertility, Female', 'Amenorrhea-become-Breast Neoplasms', 'Acquired Immunodeficiency Syndrome-evolve-Aneurysm', 'Acquired Immunodeficiency Syndrome-evolve-Atherosclerosis', 'Acquired Immunodeficiency Syndrome-evolve-Metabolic Syndrome', 'Acquired Immunodeficiency Syndrome-evolve-Dyslipidemias', 'Acquired Immunodeficiency Syndrome-evolve-Cerebrovascular Disorders', 'Aneurysm-evolve-Atherosclerosis', 'Neoplasm Metastasis-encountered-Neoplasms', 'Aneurysm-evolve-Metabolic Syndrome', 'Aneurysm-evolve-Dyslipidemias', 'Aneurysm-evolve-Cerebrovascular Disorders', 'Breast Neoplasms-acquire-Death', 'Hyperglycemia-control-Diabetes Mellitus', 'Diabetes Mellitus-provide-Hypertension', 'Diabetes Mellitus-provide-Hyperlipidemias', 'Hyperglycemia-continue-Diabetes Mellitus', 'Hypertension-continue-Diabetes Mellitus', 'Hyperlipidemias-continue-Diabetes Mellitus', 'Heart Diseases-continue-Death', 'Prostatic Neoplasms-treated-Neoplasm Metastasis', 'Drug-Related Side Effects and Adverse Reactions-observed-Thrombocytopenia', 'Hematologic Diseases-include-Neutropenia', 'Hematologic Diseases-include-Anemia', 'Hematologic Diseases-observed-Thrombocytopenia', 'Drug-Related Side Effects and Adverse Reactions-include-Hyperbilirubinemia', 'Drug-Related Side Effects and Adverse Reactions-include-Hand-Foot Syndrome', 'Acute Kidney Injury-reoperate-Hemorrhage', 'Stroke-reoperate-Hemorrhage', 'Hemorrhage-reoperate-Cholestasis', 'Hemorrhage-reoperate-Heart Block', 'Diabetes Mellitus-associated-Blindness', 'Blindness-associated-Diabetes Mellitus', 'Pulmonary Valve Insufficiency-require-Airway Obstruction', 'Ischemia-help-Death', 'Neoplasms-form-Neoplasm Metastasis', 'Death-include-Aneurysm', 'Neoplasms-adopted-Carcinoma, Hepatocellular', 'Thrombosis-adopted-Carcinoma, Hepatocellular', 'Death-caused-Fibrosis', 'Neurofibroma, Plexiform-associated-Death', 'Death-associated-Neurofibroma, Plexiform', 'Pruritus-associated-Death', 'Death-associated-Pruritus', 'Breast Neoplasms-result-Heart Arrest', 'Breast Neoplasms-induce-Heart Arrest', 'HIV Infections-associated-Hepatitis C', 'Hepatitis C-associated-HIV Infections', 'HIV Infections-associated-Liver Cirrhosis', 'Liver Cirrhosis-associated-HIV Infections', 'HIV Infections-lead-Liver Diseases', 'Infections-associated-Hepatitis C', 'Hepatitis C-associated-Infections', 'Liver Cirrhosis-lead-Coinfection', 'Infections-associated-Liver Cirrhosis', 'Liver Cirrhosis-associated-Infections', 'Liver Diseases-lead-Coinfection', 'Infections-lead-Liver Diseases', 'Carcinoma, Hepatocellular-lead-Coinfection', 'HIV Infections-infected-Liver Diseases', 'Hepatitis C-include-Kearns-Sayre Syndrome', 'Infections-include-Kearns-Sayre Syndrome', 'Carcinoma-result-Ovarian Neoplasms', 'Breast Neoplasms-related-Death', 'Neoplasms-control-Carcinogenesis', 'Neoplasm Metastasis-represent-Death', 'Hemorrhage-prevent-Thromboembolism', 'Hemorrhage-offset-Heart Valve Diseases', 'Thromboembolism-offset-Heart Valve Diseases', 'Thromboembolism-receive-Heart Valve Diseases', 'Primary Myelofibrosis-reveal-Thrombocythemia, Essential', 'Death-concentrated-Neurodegenerative Diseases', 'Acromegaly-characterized-Cardiomegaly', 'Fibrosis-appear-Endomyocardial Fibrosis', 'Acromegaly-characterized-Fibrosis', 'Acromegaly-characterized-Hypertrophy', 'Necrosis-result-Hypertrophy', 'Lung Injury-suffer-Respiratory Tract Infections', 'Pleural Effusion, Malignant-control-Sclerosis', 'Death-accepted-Myocardial Infarction', 'Stroke-range-Death', 'Stroke-rate-Death', 'Death-occur-Postoperative Complications', 'Stroke-view-Death', 'Osteoma, Osteoid-compare-Chronic Kidney Disease-Mineral and Bone Disorder', 'Aneurysm-harbor-Intracranial Aneurysm', 'Aortic Aneurysm-treated-Death', 'Hemolytic-Uremic Syndrome-directed-Central Nervous System Diseases', 'Hemolytic-Uremic Syndrome-induced-Kidney Failure, Chronic', 'Central Nervous System Diseases-induced-Kidney Failure, Chronic', 'Death-occur-Leishmaniasis, Visceral', 'Coronary Artery Disease-occur-Leishmaniasis, Visceral', 'Anemia, Hemolytic-affected-Bone Marrow Diseases', 'Death-result-Gastroenteritis', 'Pulmonary Embolism-cause-Death', 'Aneurysm-resected-Death', 'Bulbar Palsy, Progressive-include-Sleep Initiation and Maintenance Disorders', 'Paralysis-include-Sleep Initiation and Maintenance Disorders', 'Bulbar Palsy, Progressive-include-Paralysis', 'Sleep Initiation and Maintenance Disorders-include-Bulbar Palsy, Progressive', 'Aneurysm-suggest-Rupture', 'Goiter-become-Hyperkinesis', 'Aneurysm-enlarged-Rupture', 'Parvoviridae Infections-accompany-Pancytopenia', 'Infections-accompany-Pancytopenia', 'Airway Obstruction-caused-Prostatic Neoplasms', 'Aneurysm-suffer-Coronary Artery Disease', 'Inflammation-cause-Sleep Initiation and Maintenance Disorders', 'Hypertension-combined-Death', 'Lung Diseases-cause-Infections', 'Inflammation-cause-Infections', 'Adrenal Insufficiency-cause-Infections', 'Hyperglycemia-assess-Death', 'Hyperglycemia-integrated-HIV Infections', 'Death-experience-Heart Arrest', 'Multiple Sclerosis-lead-Demyelinating Diseases', 'Multiple Sclerosis-lead-Neurodegenerative Diseases', 'Central Nervous System Diseases-lead-Demyelinating Diseases', 'Central Nervous System Diseases-lead-Neurodegenerative Diseases', 'Diabetes Mellitus, Type 2-result-Diabetes Mellitus', 'Lung Neoplasms-occur-Neoplasms', 'Death-decline-Colonic Neoplasms', 'Death-decline-Inflammation', 'Hemolytic-Uremic Syndrome-occur-Anemia', 'HIV Infections-linked-Death', 'Amyotrophic Lateral Sclerosis-occur-Brain Injuries, Traumatic', 'Neurodegenerative Diseases-occur-Brain Injuries, Traumatic', 'Lung Diseases-amplify-Bronchopulmonary Dysplasia', 'Leukemia, Myelogenous, Chronic, BCR-ABL Positive-progress-Leukemia, Myeloid, Acute', 'Pneumonia-fall-Fractures, Bone', 'Vision Disorders-occur-Glaucoma', 'Neoplasms-make-Neoplasm Metastasis', 'Fractures, Bone-affected-Neoplasm Metastasis', 'Lung Diseases, Obstructive-include-Respiratory Tract Diseases', 'Pleural Effusion, Malignant-complicate-Hematologic Neoplasms', 'Pleural Effusion, Malignant-associated-Death', 'Death-associated-Pleural Effusion, Malignant', 'Hematologic Neoplasms-associated-Death', 'Death-associated-Hematologic Neoplasms', 'Bone Diseases-include-Multiple Myeloma', 'Kidney Diseases-include-Multiple Myeloma', 'Peripheral Nervous System Diseases-include-Multiple Myeloma', 'Infections-include-Multiple Myeloma', 'Venous Thromboembolism-include-Multiple Myeloma', 'Nervous System Diseases-occur-Epilepsy', 'Epilepsy-occur-Inflammation', 'Epilepsy-occur-Abnormalities, Drug-Induced', 'Neurotoxicity Syndromes-associated-Mitochondrial Diseases', 'Mitochondrial Diseases-associated-Neurotoxicity Syndromes', 'Neoplasms-evaluate-Glioblastoma', 'Gerstmann Syndrome-pacient-Distal Myopathies', 'Thrombosis-favor-Venous Thromboembolism', 'Gerstmann Syndrome-pacient-Graft vs Host Disease', 'Renal Insufficiency, Chronic-suggest-Cardiovascular Diseases', 'Heart Diseases-focus-Death', 'Death-work-Cardiovascular Diseases', 'Diabetes Mellitus-referred-Kidney Diseases', 'Hypertension-referred-Kidney Diseases', 'Death-based-Lung Neoplasms', 'Lymphoma-follow-Death', 'Wounds and Injuries-develop-Musculoskeletal Diseases', 'Wounds and Injuries-develop-Pain', 'Myositis Ossificans-misdiagnosed-Fibroma', 'Myositis Ossificans-misdiagnosed-Neoplasms', 'Myositis Ossificans-misdiagnosed-Myositis', 'Myositis Ossificans-misdiagnosed-Arthritis', 'Myositis Ossificans-misdiagnosed-Rheumatic Diseases', 'Metabolic Diseases-accelerate-Atherosclerosis', 'Metabolic Diseases-trigger-Cardiovascular Diseases', 'Atherosclerosis-trigger-Cardiovascular Diseases', 'Atherosclerosis-delay-Death', 'Carcinoma, Hepatocellular-achieve-Liver Diseases', 'Diabetes Mellitus-reduce-Neoplasms', 'Precancerous Conditions-predispose-Adenocarcinoma', 'Death-estimated-Heart Failure', 'Peripheral Nervous System Diseases-play-Hyperglycemia', 'Diabetes Mellitus-play-Hyperglycemia', 'Mitochondrial Diseases-implicated-Diabetic Angiopathies', 'Renal Insufficiency-reflect-Diabetic Foot', 'Retinal Diseases-reflect-Diabetic Foot', 'Renal Insufficiency-reflect-Death', 'Neurodegenerative Diseases-correct-Kyphosis', 'Neurodegenerative Diseases-healed-Spinal Stenosis', 'Lung Diseases-relate-Death', 'Kyphosis-relate-Death', 'Drug-Related Side Effects and Adverse Reactions-reduce-Paralysis', 'Drug-Related Side Effects and Adverse Reactions-reduce-Alzheimer Disease', 'Cystic Fibrosis-suffer-Malnutrition', 'Carcinoma, Pancreatic Ductal-indicate-Neoplasms', 'Mitral Valve Prolapse-followed-Arrhythmias, Cardiac', 'Cardiovascular Diseases-reduce-Turner Syndrome', 'Turner Syndrome-live-Hypertension', 'Turner Syndrome-include-Hypertension', 'End Stage Liver Disease-predict-Carcinoma, Hepatocellular', 'Neoplasms-reported-Multiple Myeloma', 'Lung Neoplasms-accept-Gastrointestinal Diseases', 'Gastrointestinal Diseases-accept-Breast Neoplasms', 'Neoplasms-composed-Prostatic Neoplasms', 'Prostatic Neoplasms-develop-Thyroid Neoplasms', 'Inflammation-inhibit-Cardiovascular Diseases', 'Psoriasis-include-Inflammation', 'Neoplasms-contribute-Lung Neoplasms', 'Lupus Erythematosus, Systemic-include-Inflammation', 'Death-adjusted-Neoplasms', 'Death-observe-Hip Fractures', 'Lung Diseases-include-Diabetes Mellitus', 'Glucose Metabolism Disorders-proposed-Huntington Disease', 'Death-involve-Stomach Neoplasms', 'Syncope-followed-Fatigue', 'Mucopolysaccharidosis III-find-Leukemia, Large Granular Lymphocytic', 'Trisomy 18 Syndrome-associated-Congenital Abnormalities', 'Congenital Abnormalities-associated-Trisomy 18 Syndrome', 'Chromosome Aberrations-associated-Congenital Abnormalities', 'Congenital Abnormalities-associated-Chromosome Aberrations', 'Death-remain-Respiratory Insufficiency', 'Anemia, Sickle Cell-complete-Fatigue', 'Fatigue-correlate-Pain', 'Anemia, Sickle Cell-reduce-Fatigue', 'Endometrial Neoplasms-found-Diabetes Mellitus', 'Neoplasm Metastasis-occur-Colorectal Neoplasms', 'Endometrial Neoplasms-found-Hypertension', 'Colonic Neoplasms-occur-Colorectal Neoplasms', 'Neoplasm Metastasis-associated-Multiple Sclerosis', 'Multiple Sclerosis-associated-Neoplasm Metastasis', 'Neoplasms-associated-Multiple Sclerosis', 'Multiple Sclerosis-associated-Neoplasms', 'Signs and Symptoms, Digestive-include-Parkinson Disease', 'Parkinson Disease-include-Restless Legs Syndrome', 'Urinary Bladder, Neurogenic-include-Parkinson Disease', 'Pain-include-Parkinson Disease', 'Femur Head Necrosis-related-Anemia, Sickle Cell', 'Death-surpass-HIV Infections', 'Cerebral Palsy-develop-Patellofemoral Pain Syndrome', 'Coronary Artery Disease-facilitate-Nervous System Diseases', 'Cardiovascular Diseases-reflect-Nervous System Diseases', 'Diabetes Mellitus-apply-Neoplasms', 'Thyroid Neoplasms-placed-Neoplasms', 'Venous Thromboembolism-represent-Death', 'Death-mitigate-Glaucoma', 'Lung Neoplasms-observed-Neoplasms', 'Werner Syndrome-observed-Neoplasms', 'Werner Syndrome-admitted-Skin Ulcer', 'Death-appear-Glaucoma', 'Death-cause-Deaf-Blind Disorders', 'Glaucoma-cause-Deaf-Blind Disorders', 'Dysautonomia, Familial-reach-Renal Insufficiency, Chronic', 'Neoplasms-inhibit-Carcinoma, Hepatocellular', 'Kidney Diseases-occur-Hypertension', 'Kidney Diseases-occur-Hypotension, Orthostatic', 'Neoplasms-decrease-Neoplasm Metastasis', 'Kidney Diseases-carry-Death', 'HIV Infections-living-Death', 'Death-living-HIV Infections', 'Neoplasms-expect-Airway Obstruction', 'Neoplasms-expect-Infections', 'Neoplasms-expect-Hemorrhage', 'Neoplasms-expect-Pain', 'Sepsis-lead-Multiple Organ Failure', 'Genetic Diseases, Inborn-characterized-Tetrasomy', 'Genetic Diseases, Inborn-characterized-Pulmonary Atresia', 'Anemia-reported-Neutropenia', 'Nausea-documented-Neutropenia', 'Hemophilia A-expected-Aneurysm', 'Fatigue-documented-Neutropenia', 'Hemophilia A-precipitate-Infarction', 'Death-explained-Metabolic Diseases', 'Cardiomyopathy, Hypertrophic-model-Heart Arrest', 'Cardiomyopathy, Hypertrophic-model-Death, Sudden, Cardiac', 'Skin Diseases-considered-Angina Pectoris', 'Skin Diseases-considered-Arthritis, Rheumatoid', 'Skin Diseases-considered-Multiple Sclerosis', 'Skin Diseases-considered-Neoplasms', 'Atherosclerosis-accelerated-Kidney Failure, Chronic', 'Glycogen Storage Disease-show-Hyperlipoproteinemia Type II', 'Drug-Related Side Effects and Adverse Reactions-registered-Esophageal Neoplasms', 'Drug-Related Side Effects and Adverse Reactions-registered-Pharyngeal Diseases', 'Fibrosis-occur-Myelodysplastic Syndromes', 'Myelodysplastic Syndromes-found-Primary Myelofibrosis', 'Craniopharyngioma-foreshadow-Neoplasms', 'Craniopharyngioma-foreshadow-Death', 'Neoplasms-foreshadow-Death', 'Cystic Fibrosis-cause-Respiratory Insufficiency', 'Genetic Diseases, Inborn-cause-Respiratory Insufficiency', 'Bone Diseases-related-Cystic Fibrosis', 'Aneurysm-provide-Critical Illness', 'Thrombocytosis-treat-Myeloproliferative Disorders', 'Acquired Immunodeficiency Syndrome-slow-Death', 'Atrial Fibrillation-anticoagulate-Stroke', 'Death-traced-Breast Neoplasms', 'Ocular Hypertension-treat-Aphakia', 'Osteochondritis-associated-Rupture', 'Rupture-associated-Osteochondritis', 'Neuralgia-associated-Neoplasms', 'Neoplasms-associated-Neuralgia', 'Neuralgia-classified-Nociceptive Pain', 'Neoplasms-associated-Nociceptive Pain', 'Nociceptive Pain-associated-Neoplasms', 'Infections-form-Neoplasms', 'Memory Disorders-identified-Disease', 'Neoplasms-treated-Pain Insensitivity, Congenital', 'Acquired Immunodeficiency Syndrome-develop-Neoplasms', 'Infections-develop-Neoplasms', 'Lung Neoplasms-decrease-Neoplasms', 'Fibrosis-recognized-Hypertension', 'Acquired Immunodeficiency Syndrome-base-HIV Infections', 'Paralysis-caused-Neoplasms', 'Neoplasms-classified-Fibroma', 'Neoplasms-yield-Fibroma', 'Neoplasms-yield-Sarcoma', 'Papilloma-grouped-Carcinoma, Papillary', 'Papilloma-account-Neoplasms', 'Papilloma-account-Death', 'Neoplasms-grouped-Carcinoma, Papillary', 'Carcinoma, Papillary-grouped-Neoplasms', 'Breast Neoplasms-infiltrate-Neoplasm Invasiveness', 'Neoplasms-treated-Neoplasm Metastasis', 'Carcinoma, Lobular-infiltrate-Neoplasm Invasiveness', 'Neoplasms-infiltrate-Neoplasm Invasiveness', 'Death-do-Chronic Disease', 'Breast Neoplasms-result-Chest Pain', 'Death-cause-Psychoses, Substance-Induced', 'Cardiac Output, Low-involve-Urinary Incontinence', 'Acute Kidney Injury-enhance-Death', 'Parasomnias-fall-Cardiac Output, Low', 'Pneumonia-enhance-Death', 'Pulmonary Embolism-increase-Death', 'Neoplasms-implicated-Inflammation', 'Neoplasms-implicated-Drug Hypersensitivity', 'Pain-explained-Arthritis', 'Sarcopenia-emphasized-Cardiovascular Diseases', 'Sarcopenia-emphasized-Neoplasms', 'Sarcopenia-emphasized-Communicable Diseases', 'Heart Failure-follow-Cataract', 'Osteoporosis-include-Osteoarthritis', 'Diabetes Mellitus-balanced-Cardiovascular Diseases', 'Diabetes Mellitus-balanced-Hypoglycemia', 'Cardiovascular Diseases-balanced-Hypoglycemia', 'Seizures-occur-Epilepsy', 'Pericarditis-increase-Death', 'Pleural Effusion-increase-Death', 'Hemorrhage-experience-Pregnancy Complications, Infectious', 'Hemorrhage-experience-Thrombosis', 'Thrombosis-related-Heart Diseases', 'Thrombosis-related-Anemia', 'Glaucoma-predicted-Fractures, Open', 'Mitochondrial Diseases-trigger-Nerve Degeneration', 'Drug-Related Side Effects and Adverse Reactions-trigger-Nerve Degeneration', 'Carcinogenesis-protect-Stomach Neoplasms', 'Neoplasms-associated-Carcinoma, Basal Cell', 'Carcinoma, Basal Cell-associated-Neoplasms', 'Glioblastoma-attributed-Neoplasms', 'Glioblastoma-cause-Neoplasms', 'Neoplasms-present-Leukemia, Myelomonocytic, Juvenile', 'Neoplasms-present-Primary Myelofibrosis', 'Nervous System Diseases-known-Pain Insensitivity, Congenital', 'HIV Infections-include-Chronic Pain', 'Atrophy-referred-Sarcopenia', 'Pain-masquerade-Infections', 'Kyphosis-include-Cystic Fibrosis', 'Fractures, Bone-include-Cystic Fibrosis', 'Bursitis-masquerade-Infections', 'Inflammation-include-Cystic Fibrosis', 'Cystic Fibrosis-include-Arthralgia', 'Cystic Fibrosis-related-Arthralgia', 'Cystic Fibrosis-predispose-Arthralgia', 'Kyphosis-predispose-Arthralgia', 'Fractures, Bone-predispose-Arthralgia', 'Ossification of Posterior Longitudinal Ligament-motivate-Heart Diseases', 'Inflammation-predispose-Arthralgia', 'Osteoporotic Fractures-increase-Headache', 'Cerebral Amyloid Angiopathy-demonstrate-Malformations of Cortical Development', 'Cardiotoxicity-undergo-Neoplasms', 'Headache-utilized-Migraine Disorders', 'Fanconi Syndrome-lead-Fractures, Bone', 'Parkinson Disease, Secondary-matched-Dementia', 'Parkinson Disease, Secondary-matched-Neoplasms', 'Parkinson Disease, Secondary-matched-Coronary Artery Disease', 'Neurologic Manifestations-focus-Inflammation', 'Neoplasm Metastasis-treat-Neoplasms', 'Neoplasm Metastasis-treat-Cardiovascular Diseases', 'Drug-Related Side Effects and Adverse Reactions-investigate-Leukemia', 'Hearing Disorders-diagnosed-Cystinosis', 'Memory Disorders-diagnosed-Cystinosis', 'Vision, Low-include-Vision Disorders', 'Ischemia-known-Death', 'Neoplasms-become-Acromegaly', 'Acromegaly-decrease-Death', 'Limb Deformities, Congenital-reduce-Death', 'Sleep Apnea, Obstructive-observed-Memory Disorders', 'Sleep Apnea, Obstructive-experience-Memory Disorders', 'Nervous System Diseases-confused-Alzheimer Disease', 'Cardiovascular Diseases-avoid-Myocardial Infarction', 'Fibrosis-include-Death', 'Sleep Apnea, Obstructive-affect-Sleep Wake Disorders', 'Neurodegenerative Diseases-include-Wounds and Injuries', 'Hypertension-ameliorate-Albuminuria', 'Hearing Disorders-ameliorate-Albuminuria', 'Pain-describe-Cystic Fibrosis', 'Drug-Related Side Effects and Adverse Reactions-evaluate-Neoplasms', 'Drug-Related Side Effects and Adverse Reactions-evaluate-Leukemia', 'Neoplasms-evaluate-Leukemia', 'Inflammation-accelerate-Atherosclerosis', 'Mitochondrial Diseases-lead-Hypertrophy, Left Ventricular', 'Renal Insufficiency, Chronic-accumulated-Cardiovascular Diseases', 'Renal Insufficiency, Chronic-ensue-Cardiovascular Diseases', 'Obesity, Abdominal-cause-Cardiovascular Diseases', 'Obesity, Abdominal-cause-Diabetes Mellitus', 'Hyperglycemia-cause-Cardiovascular Diseases', 'Hyperlipidemias-cause-Diabetes Mellitus', 'Neoplasms-manage-Arthritis, Rheumatoid', 'Myelodysplastic Syndromes-involve-Death', 'Gastrointestinal Hemorrhage-develop-Hemorrhage', 'Death-increase-Gastrointestinal Hemorrhage', 'Anemia, Sickle Cell-accelerate-Hemolysis', 'Anemia, Sickle Cell-include-Anemia, Hemolytic', 'Anemia, Sickle Cell-include-Inflammation', 'Anemia, Sickle Cell-include-Status Asthmaticus', 'Drug-Related Side Effects and Adverse Reactions-associated-Seizures', 'Seizures-associated-Drug-Related Side Effects and Adverse Reactions', 'Antiphospholipid Syndrome-associated-Thrombosis', 'Thrombosis-associated-Antiphospholipid Syndrome', 'Polyendocrinopathies, Autoimmune-associated-Thrombosis', 'Thrombosis-associated-Polyendocrinopathies, Autoimmune', 'Rheumatic Fever-associated-Thrombosis', 'Thrombosis-associated-Rheumatic Fever', 'Carcinoma, Hepatocellular-prevent-Fibrosis', 'Congenital Abnormalities-known-DiGeorge Syndrome', 'Cleft Palate-known-DiGeorge Syndrome', 'Gastrointestinal Diseases-known-DiGeorge Syndrome', 'Autoimmune Diseases-known-DiGeorge Syndrome', 'Infections-admitted-Jaundice', 'Hyperinsulinism-show-Thrombocytopenia', 'Hyperinsulinism-show-Anemia', 'Chronic Disease-increase-Diabetes Mellitus', 'Chronic Disease-increase-Hypertension', 'Chronic Disease-increase-Obesity', 'Chronic Disease-increase-Metabolic Syndrome', 'Cardiovascular Diseases-related-Metabolic Syndrome', 'Proteinuria-noted-Renal Insufficiency', 'Muscular Atrophy, Spinal-cause-Neuromuscular Diseases', 'Genetic Diseases, Inborn-cause-Neuromuscular Diseases', 'Glioblastoma-provide-Neoplasms', 'Respiratory Distress Syndrome-concern-Scleroderma, Systemic', 'Respiratory Distress Syndrome-present-Rheumatic Diseases', 'Hypoxia-include-Glioblastoma', 'Liver Failure-represent-Death', 'Liver Failure-represent-Chemical and Drug Induced Liver Injury', 'Death-represent-Chemical and Drug Induced Liver Injury', 'Hemophilia A-date-Alzheimer Disease', 'Hemophilia A-characterized-Coagulation Protein Disorders', 'Hemorrhage-characterized-Coagulation Protein Disorders', 'Cystic Fibrosis-transmitted-Genetic Diseases, Inborn', 'Cystic Fibrosis-predisposed-Liver Cirrhosis', 'Exocrine Pancreatic Insufficiency-influence-Liver Cirrhosis', 'Neoplasms-increased-Papillomavirus Infections', 'Cardiomyopathy, Dilated-associated-Pancreatitis', 'Pancreatitis-associated-Cardiomyopathy, Dilated', 'Aneurysm-follow-Nervous System Diseases', 'Neurilemmoma-involve-Hearing Loss', 'Neurilemmoma-involve-Deafness', 'Neurologic Manifestations-manage-Nervous System Diseases', 'Papillomavirus Infections-include-Neoplasms', 'Epstein-Barr Virus Infections-get-Multiple Sclerosis', 'Demyelinating Diseases-explained-Neuromyelitis Optica', 'Neuromyelitis Optica-considered-Multiple Sclerosis', 'Neuromyelitis Optica-misdiagnosed-Multiple Sclerosis', 'Neurotoxicity Syndromes-ameliorate-Headache Disorders, Secondary', 'Obesity-proven-Death', 'Prostatitis-correlate-Airway Obstruction', 'Renal Insufficiency, Chronic-account-Cardiovascular Diseases', 'Leukodystrophy, Globoid Cell-result-Lysosomal Storage Diseases', 'Ischemia-affected-Genetic Diseases, Inborn', 'Ischemia-affected-Cystinosis', 'Inflammation-associated-Leukodystrophy, Globoid Cell', 'Leukodystrophy, Globoid Cell-associated-Inflammation', 'Erectile Dysfunction-approved-Pulmonary Arterial Hypertension', 'Pulmonary Arterial Hypertension-characterized-Death', 'Inflammation-determine-Obesity', 'Hemophilia A-treat-Coronary Artery Disease', 'Sleep Apnea, Obstructive-address-Sleepiness', 'Sleep Apnea, Obstructive-associated-Sleep Wake Disorders', 'Sleep Wake Disorders-associated-Sleep Apnea, Obstructive', 'Death-exclude-Melanoma', 'Neoplasms-include-Adenocarcinoma', 'Catastrophic Illness-occur-Fatigue', 'Diabetic Foot-considered-Death', 'Death-lost-Neoplasms', 'Liver Cirrhosis-derived-Hepatitis B, Chronic', 'Drug-Related Side Effects and Adverse Reactions-defined-Neoplasms', 'Death-range-Carcinogenesis', 'Fibrosis-defined-Liver Failure', 'Fibrosis-surrounded-Liver Failure', 'Fibrosis-defined-Hypertension', 'Fibrosis-surrounded-Hypertension', 'Fibrosis-surrounded-End Stage Liver Disease', 'Cardiovascular Diseases-dominate-Death', 'Pneumothorax-include-Cystic Fibrosis', 'Hemoptysis-include-Cystic Fibrosis', 'Respiratory Insufficiency-include-Cystic Fibrosis', 'Neoplasms-confronted-Sensation Disorders', 'Crohn Disease-develop-Peliosis Hepatis', 'Polycythemia Vera-reduce-Headache Disorders, Secondary', 'Polycythemia Vera-reduce-Splenomegaly', 'Essential Tremor-added-Polycythemia Vera', 'Polycythemia Vera-classified-Myeloproliferative Disorders', 'Essential Tremor-reduce-Thrombocytosis', 'Polycythemia Vera-reduce-Thrombocytosis', 'Essential Tremor-classified-Myeloproliferative Disorders', 'Hepatitis C, Chronic-confirm-Carcinoma, Hepatocellular', 'Fibrosis-confirm-Carcinoma, Hepatocellular', 'Delirium-characterised-Psychomotor Disorders', 'Death-estimated-Delirium', 'Delirium-associated-Alcoholism', 'Alcoholism-associated-Delirium', 'Delirium-associated-Glucose Metabolism Disorders', 'Glucose Metabolism Disorders-associated-Delirium', 'Osteoporosis-stimulate-Fractures, Bone', 'Chronic Kidney Disease-Mineral and Bone Disorder-get-Renal Insufficiency', 'Osteomyelitis-noted-Arthritis, Infectious', 'Neoplasms-develop-Prostatic Neoplasms', 'Metabolic Diseases-lead-Chronic Kidney Disease-Mineral and Bone Disorder', 'Metabolic Diseases-predispose-Calcinosis', 'Carcinoma, Squamous Cell-contribute-Neoplasms', 'Infections-acquire-Neoplasms', 'Polycythemia Vera-separate-Polycythemia', 'Cardiovascular Diseases-remain-IgA Vasculitis', 'Cardiovascular Diseases-considered-Arthritis, Rheumatoid', 'Arthritis, Rheumatoid-observed-Death', 'Neoplasm Metastasis-respond-Neoplasms', 'Thrombocytopenia-remain-Purpura, Thrombocytopenic, Idiopathic', 'Parkinsonian Disorders-reveal-Slow Virus Diseases', 'Death-exclude-Fractures, Bone', 'Hemorrhage-represent-Carcinoma, Squamous Cell', 'Hemorrhage-represent-Endometrial Neoplasms', 'Coronary Artery Disease-base-Chest Pain', 'Prostatic Hyperplasia-produce-Urethral Obstruction', 'Arrhythmias, Cardiac-complicate-Hypoxia, Brain', 'Lung Injury-complicate-Hypoxia, Brain', 'Death-complicate-Hypoxia, Brain', 'Chest Pain-misinterpreted-Coronary Artery Disease', 'Leprosy-include-Ocular Motility Disorders', 'Leprosy-prevent-Vision Disorders', 'Ocular Motility Disorders-prevent-Vision Disorders', 'Nausea-reported-Neoplasms', 'Nausea-registered-Neoplasms', 'Nausea-registered-Acquired Immunodeficiency Syndrome', 'Polyps-contain-Neoplasms', 'Adenomatous Polyps-contain-Neoplasms', 'Neoplasms-show-Ulcer', 'Ulcer-show-Pancreatitis', 'Ulcer-show-Biliary Tract Neoplasms', 'Ulcer-detect-Neoplasms', 'Death-accompanied-Cerebral Intraventricular Hemorrhage', 'Neoplasm Metastasis-metastasize-Jaw Diseases', 'Sclerosis-observe-Death', 'Bronchopneumonia-document-Pulmonary Embolism', 'Sepsis-document-Pulmonary Embolism', 'Myocardial Infarction-document-Pulmonary Embolism', 'Ureteral Diseases-control-Fistula', 'Meningeal Neoplasms-followed-Neurilemmoma', 'Neoplasms-followed-Neurilemmoma', 'Constipation-correlated-Urinary Incontinence', 'Immunologic Deficiency Syndromes-characterized-Neoplasms', 'Immunologic Deficiency Syndromes-characterized-Infections', 'HIV Infections-forthcoming-Uterine Cervical Neoplasms', 'Sleep Initiation and Maintenance Disorders-disseminate-Immunologic Deficiency Syndromes', 'Hypertension-prevent-Cerebrovascular Disorders', 'Renal Insufficiency, Chronic-develop-Motor Neuron Disease', 'Hyperoxaluria-develop-Motor Neuron Disease', 'Peripheral Nervous System Diseases-complicate-Hyperoxaluria', 'Bone Marrow Failure Disorders-appear-Anemia', 'Bone Marrow Failure Disorders-appear-Agranulocytosis', 'Bone Marrow Failure Disorders-appear-Leukemia, Hairy Cell', 'Pelizaeus-Merzbacher Disease-prevent-Neoplasms', 'Pelizaeus-Merzbacher Disease-present-Gastroesophageal Reflux', 'Pelizaeus-Merzbacher Disease-present-Gastritis', 'Pelizaeus-Merzbacher Disease-present-Cystitis', 'Pelizaeus-Merzbacher Disease-present-Cryptorchidism', 'Pelizaeus-Merzbacher Disease-present-Neoplasms', 'Gastroesophageal Reflux-increase-Neoplasms', 'Pelizaeus-Merzbacher Disease-discovered-Neoplasms', 'Gastritis-increase-Neoplasms', 'Cystitis-increase-Neoplasms', 'Cryptorchidism-increase-Neoplasms', 'Carcinoma, Basal Cell-make-Neoplasms', 'Neoplasms-hospitalized-Death', 'Hypoprothrombinemias-emerge-Osteopetrosis', 'Hypoprothrombinemias-accompanied-Acidosis, Renal Tubular', 'Hypoprothrombinemias-accompanied-Acidosis', 'Hypoprothrombinemias-feature-Hypokalemia', 'Hypoprothrombinemias-feature-Paralysis', 'Acidosis, Renal Tubular-feature-Hypokalemia', 'Acidosis, Renal Tubular-feature-Paralysis', 'Acidosis-feature-Hypokalemia', 'Acidosis-feature-Paralysis', 'Multiple Sclerosis-induce-Headache Disorders, Secondary', 'Cystic Fibrosis-hallmarked-Inflammation', 'Cystic Fibrosis-resolve-Respiratory Tract Infections', 'Cystic Fibrosis-hallmarked-Death', 'Inflammation-resolve-Respiratory Tract Infections', 'Respiratory Tract Infections-resolve-Death', 'Drug-Related Side Effects and Adverse Reactions-compared-Glucosephosphate Dehydrogenase Deficiency', 'Liver Failure-spread-Hemorrhage', 'Liver Failure-spread-Blood Coagulation Disorders', 'Neoplasms-live-Bone Neoplasms', 'Neoplasms-invade-Pain', 'Neoplasms-lead-Fractures, Bone', 'Neoplasms-lead-Nervous System Diseases', 'Neoplasms-lead-Paralysis', 'Diabetes Mellitus-assess-Renal Insufficiency', 'Hyperlipoproteinemia Type II-considered-Atherosclerosis', 'Hyperlipoproteinemia Type II-considered-Cardiovascular Diseases', 'Lice Infestations-caused-Tinea Capitis', 'Hyperlipoproteinemia Type II-cause-Cerebral Infarction', 'Adrenal Insufficiency-described-Addison Disease', 'Polycystic Ovary Syndrome-develop-Ovarian Hyperstimulation Syndrome', 'Mouth Neoplasms-represent-Neoplasms', 'Diabetes Mellitus-recommended-Vision Disorders', 'Neoplasms-include-Lymphoma, Non-Hodgkin', 'Neoplasms-include-Hodgkin Disease', 'Diabetes Mellitus-followed-Cardiovascular Diseases', 'Neuromuscular Diseases-suffer-Amyotrophic Lateral Sclerosis', 'Neuromuscular Diseases-suffer-Muscular Dystrophy, Duchenne', 'Cellulitis-associated-Onychomycosis', 'Onychomycosis-associated-Cellulitis', 'Cellulitis-associated-Ulcer', 'Ulcer-associated-Cellulitis', 'Cellulitis-associated-Obesity', 'Obesity-associated-Cellulitis', 'Multiple Myeloma-play-Kidney Diseases', 'Diabetes Mellitus-evaluate-Corneal Diseases', 'Neoplasms-coupled-Death', 'Glioblastoma-cause-Death', 'Brain Neoplasms-cause-Death', 'Parkinson Disease-suffer-Dyskinesia, Drug-Induced', 'Parkinson Disease-range-Hallucinations', 'Dyskinesia, Drug-Induced-range-Hallucinations', 'Alzheimer Disease-associate-Nerve Degeneration', 'Nerve Degeneration-associate-Alzheimer Disease', 'Colitis, Ulcerative-become-Gastrointestinal Diseases', 'Genetic Diseases, Inborn-characterized-Primary Dysautonomias', 'Hypogonadism-result-Infertility, Female', 'Calculi-evaluate-Neuroendocrine Tumors', 'Neoplasms-represent-Leukemia, Myeloid', 'Myeloproliferative Disorders-represent-Leukemia, Myeloid', 'Thrombocythemia, Essential-represent-Leukemia, Myeloid', 'Neonatal Abstinence Syndrome-report-Death', 'Death-base-Neonatal Abstinence Syndrome', 'Heart Failure-calculate-Death', 'Bone Diseases-evaluate-Hepatitis, Viral, Human', 'Osteoporosis-exert-Inflammation', 'Movement Disorders-increase-Pain', 'Dementia-diagnosed-Headache Disorders, Secondary', 'Prostatic Neoplasms-remain-Death', 'Neurologic Manifestations-present-Coma', 'Coma-present-Postpartum Hemorrhage', 'Aneurysm-placed-Limb Deformities, Congenital', 'Death-placed-Limb Deformities, Congenital', 'Infections-placed-Limb Deformities, Congenital', 'Limb Deformities, Congenital-placed-Aneurysm, Ruptured', 'Neoplasms-produce-Pleural Effusion', 'Hemochromatosis-lead-Death', 'Sleep Disorders, Circadian Rhythm-associated-Death', 'Death-associated-Sleep Disorders, Circadian Rhythm', 'Neoplasms-develop-Hematologic Diseases', 'Neoplasms-develop-Fractures, Stress', 'Death-reported-Chronic Disease', 'Death-construct-Chronic Disease', 'Death-represent-Cardiovascular Diseases', 'Colorectal Neoplasms-refer-Neoplasms', 'Diabetes Mellitus, Type 2-present-Colorectal Neoplasms', 'Thrombocythemia, Essential-exclude-Primary Myelofibrosis', 'Cell Transformation, Viral-estimated-Thrombocythemia, Essential', 'Cell Transformation, Viral-estimated-Polycythemia Vera', 'Neoplasms-suffer-Hemorrhage', 'Neoplasms-inserted-Pulmonary Embolism', 'Death-worsened-Musculoskeletal Diseases', 'Death-worsened-Scoliosis', 'Respiratory Insufficiency-worsened-Musculoskeletal Diseases', 'Respiratory Insufficiency-worsened-Scoliosis', 'Fever-include-Drug-Related Side Effects and Adverse Reactions', 'Motor Neuron Disease-signe-Alzheimer Disease', 'Turner Syndrome-associated-Heart Diseases', 'Heart Diseases-associated-Turner Syndrome', 'Heart Arrest-induce-Colorectal Neoplasms', 'Retinal Degeneration-prevent-Vision Disorders', 'Chronic Disease-result-Pleural Effusion', 'Acquired Immunodeficiency Syndrome-result-Pleural Effusion', 'Pleural Effusion-result-Opportunistic Infections', 'Pleural Effusion-result-Acquired Immunodeficiency Syndrome', 'Pleural Effusion-result-Sarcoma, Kaposi', 'Pleural Effusion-result-Lymphoma, Non-Hodgkin', 'Seizures-develop-Muscle Hypotonia', 'Seizures-develop-Hypokinesia', 'Lymphoma-affected-Neoplasms', 'Neoplastic Syndromes, Hereditary-undergo-Leukemia, Myelogenous, Chronic, BCR-ABL Positive', 'Death-calculated-Leukemia', 'Epilepsy-include-Neurodegenerative Diseases', 'Neoplasms-characterized-Obesity', 'Neoplasms-characterized-Inflammation', 'Death-use-Wounds and Injuries', 'Head and Neck Neoplasms-treat-Neoplasms', 'Prostatic Neoplasms-screened-Death', 'Diabetes Mellitus-predispose-Diabetic Foot', 'Death-involve-Colorectal Neoplasms', 'Immunologic Deficiency Syndromes-describe-Muscle Hypotonia', 'Breast Neoplasms-ensure-Drug-Related Side Effects and Adverse Reactions', 'Drug-Related Side Effects and Adverse Reactions-shift-Breast Neoplasms', 'Ocular Motility Disorders-involve-Neoplasms', 'Ocular Motility Disorders-involve-Neurodegenerative Diseases', 'Neoplasms-need-Lung Diseases', 'Colitis, Ulcerative-characterized-Inflammation', 'Heart Valve Diseases-account-Aortic Valve Stenosis', 'Heart Valve Diseases-account-Mitral Valve Insufficiency', 'Respiratory Tract Diseases-develop-Neoplasms', 'Pancreatic Neoplasms-present-Duodenal Obstruction', 'Neoplasms-sedated-Death', 'Kidney Diseases-ameliorate-Lupus Erythematosus, Systemic', 'HIV Infections-predispose-Infections', 'HIV Infections-gain-Nervous System Diseases', 'Nervous System Diseases-gain-HIV Infections', 'Malnutrition-help-Infections', 'Glioblastoma-resected-Neoplasms', 'Glioblastoma-found-Death', 'Brain Diseases-describe-Neurodegenerative Diseases', 'Nerve Degeneration-induce-Brain Ischemia', 'Stroke-demonstrate-Coronary Artery Disease', 'Breast Neoplasms-find-Heart Arrest', 'Death-related-Lung Diseases, Interstitial', 'Death-thought-Lung Diseases, Interstitial', 'Death-related-Respiratory Tract Infections', 'Death-thought-Respiratory Tract Infections', 'Death-thought-Pneumonia', 'Drug-Related Side Effects and Adverse Reactions-entail-Hypotension', 'Drug-Related Side Effects and Adverse Reactions-entail-Anemia', 'Drug-Related Side Effects and Adverse Reactions-entail-Neutropenia', 'Sepsis-suffer-Leukoencephalopathies', 'Drug-Related Side Effects and Adverse Reactions-entail-Thrombocytopenia', 'Sepsis-suffer-Pulmonary Embolism', 'Chronic Disease-include-Substance-Related Disorders', 'Colorectal Neoplasms, Hereditary Nonpolyposis-identify-Endometrial Neoplasms', 'Thalassemia-cause-Anemia', 'Blood Coagulation Disorders, Inherited-cause-Anemia', 'Quadriplegia-create-Brain Injuries', 'Brain Injuries-exceed-Quadriplegia', 'Tumor Lysis Syndrome-occur-Hematologic Neoplasms', 'Kidney Diseases-associated-Neoplasms', 'Neoplasms-associated-Kidney Diseases', 'Neoplasms-associated-Acute Kidney Injury', 'Acute Kidney Injury-associated-Neoplasms', 'Venous Thromboembolism-outnumber-Hemorrhage', 'Venous Thromboembolism-outnumber-Death', 'Hemorrhage-outnumber-Death', 'Death-studied-Acquired Immunodeficiency Syndrome', 'Neoplasms-calculated-Carcinoma, Hepatocellular', 'Bone Diseases, Metabolic-include-Bone Diseases', 'Pelvic Neoplasms-disappear-Pain', 'Heart Diseases-described-Basal Ganglia Cerebrovascular Disease', 'Heart Diseases-occur-Immunologic Deficiency Syndromes', 'Heart Diseases-occur-Diabetes Mellitus', 'Hypertension-affect-Turner Syndrome', 'Turner Syndrome-treat-Heart Diseases', 'Respiratory Tract Infections-understand-Cystic Fibrosis', 'Pneumonia-understand-Cystic Fibrosis', 'Lung Diseases-understand-Cystic Fibrosis', 'Addison Disease-combined-Thyroiditis, Autoimmune', 'Addison Disease-combined-Diabetes Mellitus', 'Cystinosis-account-Dehydration', 'Diabetes Mellitus-describe-Cystic Fibrosis', 'Neoplasms-found-Colonic Neoplasms', 'Liver Diseases-result-Fibrosis', 'Cholangitis-form-Inflammatory Bowel Diseases', 'Obesity-facilitate-Weight Loss', 'Diabetes Mellitus-control-Cardiovascular Diseases', 'Meningeal Carcinomatosis-associated-Carcinoma, Squamous Cell', 'Carcinoma, Squamous Cell-associated-Meningeal Carcinomatosis', 'Klippel-Trenaunay-Weber Syndrome-characterized-Hemangioma', 'Klippel-Trenaunay-Weber Syndrome-characterized-Hypertrophy', 'Venous Thrombosis-cause-Hypertension, Pulmonary', 'Flatfoot-produce-Heart Failure', 'Flatfoot-produce-Disseminated Intravascular Coagulation', 'Flatfoot-produce-Kasabach-Merritt Syndrome', 'Hemangioma-produce-Heart Failure', 'Hemangioma-produce-Disseminated Intravascular Coagulation', 'Hemangioma-produce-Kasabach-Merritt Syndrome', 'Turner Syndrome-monitored-Hepatomegaly', 'Acromegaly-reduce-Heart Diseases', 'Turner Syndrome-monitored-Hypertension', 'Turner Syndrome-monitored-Diabetes Mellitus', 'Turner Syndrome-monitored-Dyslipidemias', 'Arthritis, Rheumatoid-occur-Inflammation', 'Bile Duct Neoplasms-use-Fever', 'Diabetes Mellitus-remain-Renal Insufficiency', 'Fibrosis-replace-Bile Duct Neoplasms', 'Fibrosis-observed-Neoplasms', 'Necrosis-replace-Bile Duct Neoplasms', 'Necrosis-observed-Neoplasms', 'Bile Duct Neoplasms-observed-Neoplasms', 'Neoplasm Metastasis-consider-Neoplasms', 'Death-include-Muscular Atrophy, Spinal', 'Drug-Related Side Effects and Adverse Reactions-consist-Neutropenia', 'Drug-Related Side Effects and Adverse Reactions-consist-Constipation', 'Parasitic Diseases-lead-Infections', 'Death-driven-Coronary Artery Disease', 'Cerebral Hemorrhage-preferred-Thromboembolism', 'Glaucoma-diminish-Eye Pain', 'Glaucoma-continue-Papilledema', 'Glaucoma-continue-Retinal Detachment', 'Eye Pain-diminish-Papilledema', 'Eye Pain-continue-Retinal Detachment', 'Papilledema-continue-Retinal Detachment', 'Turner Syndrome-consist-Fractures, Bone', 'Turner Syndrome-involved-Fractures, Bone', 'Turner Syndrome-consist-Osteoporosis', 'Turner Syndrome-involved-Osteoporosis', 'Turner Syndrome-involved-Coronary Artery Disease', 'Turner Syndrome-involved-Hypertension', 'Turner Syndrome-involved-Stroke', 'Turner Syndrome-involved-Diabetes Mellitus, Type 2', 'Infections-stratified-Granulomatous Disease, Chronic', 'Pregnancy Complications, Infectious-stratified-Granulomatous Disease, Chronic', 'Stomatitis, Aphthous-recognized-Mouth Diseases', 'Death-study-Coronary Artery Disease', 'Death-highlighted-Coronary Artery Disease', 'Death-base-Respiratory Insufficiency', 'Prostatic Neoplasms-determined-Neoplasms', 'Death-determined-Neoplasms', 'Neoplasms-determine-Prostatic Neoplasms', 'Neoplasms-determine-Death', 'Neoplasms-injected-Thyroid Nodule', 'Carcinoma, Papillary-include-Neoplasms', 'Metabolic Diseases-exist-Liver Diseases', 'Liver Failure-use-Liver Diseases', 'Fibrosis-divided-Primary Myelofibrosis', 'Death-decrease-Respiratory Tract Infections', 'Death-decrease-Hemorrhage', 'Neoplasms-expected-Death', 'Coronary Artery Disease-recognized-Death', 'Coronary Artery Disease-recognized-Aortic Aneurysm, Abdominal', 'Hip Fractures-viewed-Death', 'Heart Diseases-viewed-Death', 'Stroke-viewed-Death', 'Neoplasms-viewed-Death', 'Sepsis-viewed-Death', 'Pneumonia-viewed-Death', 'Neurodegenerative Diseases-turn-Neurotoxicity Syndromes', 'Parkinson Disease-turn-Neurotoxicity Syndromes', 'Cell Transformation, Viral-show-Polycythemia Vera', 'Angina Pectoris-prove-Coronary Artery Disease', 'REM Sleep Parasomnias-include-Head and Neck Neoplasms', 'Sleep Wake Disorders-prioritized-REM Sleep Parasomnias', 'Movement Disorders-characterized-Retinal Degeneration', 'Leukemia, Myeloid, Acute-prevent-Invasive Fungal Infections', 'Deglutition Disorders-increase-Fatigue', 'Fatigue-related-Deglutition Disorders', 'Neoplasms-identify-Digestive System Neoplasms', 'Neoplasms-scheduled-Cardiotoxicity', 'Pulmonary Disease, Chronic Obstructive-excluded-Respiratory Tract Diseases', 'Asthma-excluded-Respiratory Tract Diseases', 'Mandibular Nerve Injuries-produce-Neuralgia', 'Prostatic Neoplasms-rank-Neoplasms', 'Joint Diseases-include-Gout', 'Drug Hypersensitivity-occur-Death', 'Drug Hypersensitivity-exhibit-Pain', 'Death-exhibit-Pain', 'Fractures, Bone-thrive-Cardiovascular Abnormalities', 'Fractures, Bone-remain-Death', 'Fractures, Bone-ascertain-Death', 'Death-adjusted-Fractures, Bone', 'Death-persist-Fractures, Bone', 'Neoplasms-produce-Paralysis', 'Death-tend-Fractures, Bone', 'Death-decline-Fractures, Bone', 'Urinary Bladder, Overactive-reduce-Urinary Incontinence, Urge', 'Cystic Fibrosis-benefit-Lung Diseases', 'Cystic Fibrosis-reduce-Infections', 'Atherosclerosis-include-Aneurysm', 'Cardiovascular Diseases-termed-Obesity', 'Seizures-include-Obesity', 'Seizures-attributed-Obesity', 'Osteoarthritis-suggest-Obesity', 'Death-attributed-Obesity', 'Obesity-undergo-Osteoarthritis', 'Cardiovascular Diseases-suggest-Obesity', 'Death-suggest-Obesity', 'Death-discussed-Drug-Related Side Effects and Adverse Reactions', 'Cardiovascular Diseases-include-Malocclusion', 'Cardiovascular Diseases-include-Rheumatic Fever', 'Diabetes Mellitus-assess-Hip Fractures', 'Cardiovascular Diseases-include-Rheumatic Heart Disease', 'Multiple Myeloma-complicated-Acute Kidney Injury', 'Acute Kidney Injury-required-Renal Insufficiency, Chronic', 'Diabetes Mellitus-sustain-Hip Fractures', 'Kidney Diseases-manifest-Acute Kidney Injury', 'Acute Kidney Injury-manifest-Kidney Diseases', 'Joint Diseases-account-Musculoskeletal Diseases', 'Synovitis-account-Musculoskeletal Diseases', 'Pseudomonas Infections-threat-Death', 'Brain Diseases-seen-Adrenal Hyperplasia, Congenital', 'Death-account-Cardiovascular Diseases', 'Multiple Endocrine Neoplasia-characterized-Neuroendocrine Tumors', 'Non-alcoholic Fatty Liver Disease-progress-Fatty Liver', 'Non-alcoholic Fatty Liver Disease-increase-Liver Cirrhosis', 'Non-alcoholic Fatty Liver Disease-present-Metabolic Syndrome', 'Fatty Liver-increase-Liver Cirrhosis', 'Neoplasms-caused-Genetic Diseases, Inborn', 'Leukemia, Myelogenous, Chronic, BCR-ABL Positive-short-Death', 'Chronic Pain-influence-Peripheral Nervous System Diseases', 'Chronic Pain-influence-Inflammation', 'HIV Infections-induced-Peripheral Nervous System Diseases', 'HIV Infections-influence-Peripheral Nervous System Diseases', 'HIV Infections-influence-Inflammation', 'Adrenal Insufficiency-contribute-Headache Disorders, Primary', 'Headache Disorders, Secondary-rated-Dystonia', 'Cardiovascular Diseases-help-Death', 'Papillomavirus Infections-reduce-Neoplasms', 'Thromboembolism-increase-Death', 'Hyperparathyroidism-caused-Carcinoid Tumor', 'Atherosclerosis-pose-Ischemia', 'Atherosclerosis-share-Neoplasms', 'Musculoskeletal Diseases-prevent-Fractures, Bone', 'Fibrosis-exacerbate-Diabetes Mellitus', 'Multiple Myeloma-cause-Cardiomyopathies', 'Multiple Myeloma-cause-Heart Failure', 'Multiple Myeloma-cause-Heart Diseases', 'Neoplasms-develop-Carcinogenesis', 'Infections-treat-Death', 'Ataxia-show-Leukoencephalopathies', 'Pain-performed-Fractures, Bone', 'Cardiovascular Diseases-study-Diabetes Mellitus', 'Death-study-Diabetes Mellitus', 'Diabetes Mellitus-occurred-Cardiovascular Diseases', 'Death-found-Diabetes Mellitus', 'Death-occurred-Cardiovascular Diseases', 'Inflammation-impact-Spinal Cord Injuries', 'Diabetes Mellitus-found-Cardiovascular Diseases', 'Cardiovascular Diseases-promote-Wounds and Injuries', 'Inflammation-discussed-Pain', 'Inflammation-discussed-Obesity', 'Inflammation-exacerbate-Wounds and Injuries', 'Inflammation-worsen-Pain', 'Inflammation-amplify-Genetic Diseases, Inborn', 'Inflammation-amplify-Wounds and Injuries', 'Inflammation-amplify-Death', 'Inflammation-considered-Wounds and Injuries', 'Inflammation-considered-Spinal Cord Injuries', 'Infections-related-Lupus Erythematosus, Systemic', 'Infections-hypothesized-Lupus Erythematosus, Systemic', 'Brain Injuries, Traumatic-guide-Brain Injuries', 'Inflammation-include-Lupus Erythematosus, Systemic', 'Anemia, Iron-Deficiency-identify-Hemorrhage', 'Breast Neoplasms-followed-Lung Neoplasms', 'Pelizaeus-Merzbacher Disease-characterized-Nystagmus, Pathologic', 'Pelizaeus-Merzbacher Disease-characterized-Movement Disorders', 'Pelizaeus-Merzbacher Disease-characterized-Ataxia', 'Pelizaeus-Merzbacher Disease-characterized-Muscle Spasticity', 'Death-predicted-Peripheral Arterial Disease', 'Demyelinating Diseases-characterized-Nystagmus, Pathologic', 'Death-predicted-Lung Diseases, Obstructive', 'Death-predicted-Kidney Failure, Chronic', 'Demyelinating Diseases-characterized-Movement Disorders', 'Demyelinating Diseases-characterized-Ataxia', 'Demyelinating Diseases-characterized-Muscle Spasticity', 'Thrombosis-occur-Necrosis', 'Venous Thrombosis-identified-Peripheral Nervous System Diseases', 'Death-reduce-Drug Overdose', 'Hypertension-compare-Arthritis, Psoriatic', 'Diabetes Mellitus-compare-Arthritis, Psoriatic', 'Arthritis, Psoriatic-presented-Arthritis', 'Cystic Fibrosis-associated-Bacterial Infections', 'Bacterial Infections-associated-Cystic Fibrosis', 'Cystic Fibrosis-associated-Respiratory Insufficiency', 'Respiratory Insufficiency-associated-Cystic Fibrosis', 'Bacterial Infections-lead-Respiratory Insufficiency', 'Opportunistic Infections-replace-Acquired Immunodeficiency Syndrome', 'Pancreatic Neoplasms-treat-Death', 'Pancreatic Neoplasms-result-Death', 'Opportunistic Infections-replace-Death', 'Osteoporotic Fractures-impose-Death', 'Fractures, Bone-impose-Death', 'Pelvic Neoplasms-occur-Bone Neoplasms', 'Pelvic Neoplasms-occur-Wounds and Injuries', 'Fractures, Stress-use-Fractures, Bone', 'Osteoporosis-associated-Fractures, Stress', 'Fractures, Stress-associated-Osteoporosis', 'Osteoporosis-associated-Hypertension', 'Hypertension-associated-Osteoporosis', 'Fractures, Stress-associated-Hypertension', 'Hypertension-associated-Fractures, Stress', 'Congenital, Hereditary, and Neonatal Diseases and Abnormalities-associated-Turner Syndrome', 'Turner Syndrome-associated-Congenital, Hereditary, and Neonatal Diseases and Abnormalities', 'Fractures, Stress-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-Fractures, Stress', 'Anemia-associated-Lung Neoplasms', 'Lung Neoplasms-associated-Anemia', 'Chronic Disease-experience-Diabetes Mellitus', 'Chronic Disease-experience-Hyperlipidemias', 'Chronic Disease-experience-Obesity', 'Chronic Disease-experience-Cardiovascular Diseases', 'Glaucoma-tend-Vision Disorders', 'Cardiovascular Diseases-characterized-Albuminuria', 'Hypokinesia-combined-Dyskinesia, Drug-Induced', 'Muscle Rigidity-combined-Dyskinesia, Drug-Induced', 'Tremor-combined-Dyskinesia, Drug-Induced', 'Neoplasms-combined-Sarcoma, Kaposi', 'Death-estimate-Aneurysm', 'Cerebral Hemorrhage-provide-Leukodystrophy, Globoid Cell', 'Sarcoma-treated-Neoplasms', 'Venous Thromboembolism-base-Thrombophilia', 'Diabetes Mellitus-increase-Vision Disorders', 'Diabetes Mellitus-prevent-Vision Disorders', 'Diabetes Mellitus-include-Edema', 'Edema-include-Diabetes Mellitus', 'Parkinson Disease-experience-Muscle Rigidity', 'Breast Neoplasms-influenced-Death', 'Cardiovascular Diseases-caused-Cerebrovascular Disorders', 'Pain-include-Neutropenia', 'Pain-include-Seizures', 'Polyps-found-Colitis', 'Polyps-found-Diverticulum', 'Hyperlipidemias-developed-Obesity', 'Fibrosis-represented-Obesity', 'Inflammation-represented-Obesity', 'Death-influenced-Thrombocytopenia', 'Hyponatremia-underlie-Neoplasms', 'Diabetes Mellitus-deserve-Hypertension', 'Diabetes Mellitus-deserve-Neoplasms', 'Diabetes Mellitus-deserve-Heart Failure', 'Brain Injuries, Traumatic-show-Dysarthria', 'Thrombocytosis-associated-Death', 'Death-associated-Thrombocytosis', 'Cardiovascular Diseases-develop-Spinal Cord Injuries', 'Death-develop-Spinal Cord Injuries', 'Atherosclerosis-extrapolated-Cardiovascular Diseases', 'Death-develop-Cardiovascular Diseases', 'Spinal Cord Injuries-develop-Cardiovascular Diseases', 'Seizures-treat-Cardiovascular Diseases', 'Seizures-treat-Obesity', 'Seizures-serve-Diabetes Mellitus', 'Headache Disorders, Secondary-develop-Gingival Overgrowth', 'Hyperlipidemias-include-Obesity', 'Metabolic Diseases-overlap-Psoriasis', 'Myocardial Infarction-increased-Psoriasis', 'Obesity-overlap-Psoriasis', 'Diabetes Mellitus-overlap-Psoriasis', 'Stroke-increased-Psoriasis', 'Inflammation-display-Atherosclerosis', 'Stroke-include-Anemia, Sickle Cell', 'Cerebral Infarction-include-Anemia, Sickle Cell', 'Hypertension-include-Anemia, Sickle Cell', 'HIV Infections-increase-Viremia', 'Inflammation-terminated-Death', 'Infections-follow-Cardiovascular Diseases', 'Fragile X Syndrome-lead-Musculoskeletal Diseases', 'Craniofacial Abnormalities-overlap-Ehlers-Danlos Syndrome', 'Bone Diseases, Metabolic-improve-Loeys-Dietz Syndrome', 'Death-ensue-Musculoskeletal Diseases', 'Cleft Palate-talipe-Clubfoot', 'Clubfoot-require-Hernia, Inguinal', 'Clubfoot-require-Aneurysm', 'Mycoses-include-Opportunistic Infections', 'Opportunistic Infections-remain-Death', 'Mycoses-remain-Death', 'Menorrhagia-followed-Endometriosis', 'Ovarian Diseases-followed-Endometriosis', 'Breast Neoplasms-continue-Death', 'Infertility, Female-decrease-Death', 'Lupus Erythematosus, Systemic-include-Long QT Syndrome', 'Kidney Diseases-determine-Death', 'Cholangitis, Sclerosing-characterized-Inflammation', 'Cholangitis, Sclerosing-characterized-Fibrosis', 'Cholangitis, Sclerosing-affect-Inflammatory Bowel Diseases', 'Liver Diseases-characterized-Inflammation', 'Inflammation-characterized-End Stage Liver Disease', 'Myeloproliferative Disorders-associated-Primary Myelofibrosis', 'Primary Myelofibrosis-associated-Myeloproliferative Disorders', 'Essential Tremor-affect-Thrombosis', 'Cholangitis, Sclerosing-include-Pruritus', 'Cholangitis, Sclerosing-include-Fatigue', 'Cholangitis, Sclerosing-include-Bone Diseases, Metabolic', 'Cholangitis, Sclerosing-include-Cholangitis', 'Cholangitis, Sclerosing-include-Polyps', 'Cholangitis, Sclerosing-include-Neoplasms', 'Cholangiocarcinoma-include-Cholangitis, Sclerosing', 'Fallopian Tube Diseases-lower-Dyslexia', 'Fallopian Tube Diseases-lower-Neoplasms', 'Fallopian Tube Diseases-lower-Obesity', 'Fallopian Tube Diseases-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-Fallopian Tube Diseases', 'Dyslexia-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-Dyslexia', 'Pain-decrease-Nervous System Diseases', 'Microphthalmos-include-Trisomy 13 Syndrome', 'Heart Defects, Congenital-include-Trisomy 13 Syndrome', 'Death-estimated-Diabetes Mellitus', 'Death-allograft-Heart Diseases', 'Intellectual Disability-stave-Heart Diseases', 'Coma-remain-Paralysis', 'Paralysis-resemble-Hypokinesia', 'Fibrosis-related-Carcinoma, Hepatocellular', 'Psoriasis-induce-Inflammation', 'Psoriasis-mimic-Arthritis, Psoriatic', 'Heart Diseases-discovered-Genetic Diseases, Inborn', 'Genetic Diseases, Inborn-confronted-Cystic Fibrosis', 'Turner Syndrome-thought-Hypothyroidism', 'Turner Syndrome-thought-Deafness', 'Turner Syndrome-thought-Osteoporosis', 'Turner Syndrome-thought-Infertility, Female', 'Lung Diseases-become-Cystic Fibrosis', 'Cystic Fibrosis-include-Diabetes Mellitus', 'Death-describe-Cerebral Palsy', 'Death-identified-Cerebral Palsy', 'Genetic Diseases, Inborn-characterized-Gonadal Disorders', 'Hypertension-suggest-Adrenocortical Adenoma', 'Hypokalemia-suggest-Adrenocortical Adenoma', 'Hepatitis C, Chronic-range-Chemical and Drug Induced Liver Injury', 'Infections-recognized-Respiratory Tract Infections', 'Noncommunicable Diseases-recognized-Acquired Immunodeficiency Syndrome', 'Neoplasms-linked-Infections', 'Sarcoma, Kaposi-linked-Infections', 'Lymphoma, Non-Hodgkin-linked-Infections', 'Acquired Immunodeficiency Syndrome-survive-Infections', 'Carcinoma, Squamous Cell-present-Neoplasm Metastasis', 'Death-occur-Liver Diseases', 'Horner Syndrome-play-Death', 'Opportunistic Infections-added-HIV Infections', 'Opportunistic Infections-added-Pneumonia, Pneumocystis', 'Opportunistic Infections-added-Infections', 'Opportunistic Infections-added-Meningitis, Cryptococcal', 'Infections-added-HIV Infections', 'Dwarfism, Pituitary-increase-Hypertension', 'Dwarfism, Pituitary-increase-Cardiovascular Diseases', 'Infections-added-Pneumonia, Pneumocystis', 'Infections-added-Meningitis, Cryptococcal', 'Acquired Immunodeficiency Syndrome-acquire-Immunologic Deficiency Syndromes', 'Death-observed-Pancreatitis', 'Pancreatitis-yield-Death', 'Deglutition Disorders-include-Infections', 'Acquired Immunodeficiency Syndrome-include-Deglutition Disorders', 'Abdominal Pain-caused-Lymphoma', 'Abdominal Pain-caused-Sarcoma, Kaposi', 'Heart Failure-preceded-Myocardial Infarction', 'Nausea-caused-Lymphoma', 'Nausea-caused-Sarcoma, Kaposi', 'Vomiting-caused-Lymphoma', 'Vomiting-caused-Sarcoma, Kaposi', 'Weight Loss-caused-Lymphoma', 'Weight Loss-caused-Sarcoma, Kaposi', 'Lung Diseases, Obstructive-caused-Lymphoma', 'Lung Diseases, Obstructive-caused-Sarcoma, Kaposi', 'Abdominal Pain-indicate-Pancreatitis', 'Diarrhea-short-Acquired Immunodeficiency Syndrome', 'Malnutrition-short-Acquired Immunodeficiency Syndrome', 'Weight Loss-short-Acquired Immunodeficiency Syndrome', 'Death-lowered-Neoplasms', 'Prostatic Neoplasms-lowered-Neoplasms', 'Coronary Artery Disease-seem-Diabetes Mellitus', 'Coronary Artery Disease-seem-Brugada Syndrome', 'Coronary Artery Disease-seem-Alopecia', 'Cholestasis, Extrahepatic-include-Death', 'Neoplasms-acquire-Carcinogenesis', 'Sarcoma-calculated-Neoplasms', 'Sarcoma-calculated-Head and Neck Neoplasms', 'Neoplasms-calculated-Sarcoma', 'Neoplasms-calculated-Head and Neck Neoplasms', 'Death-occur-Pulmonary Disease, Chronic Obstructive', 'Neuroendocrine Tumors-metastasize-Neoplasm Metastasis', 'Fibrosis-depend-Neoplasms', 'Cholestasis, Extrahepatic-depend-Neoplasm Metastasis', 'Cholestasis, Extrahepatic-depend-Neoplasms', 'Neoplasm Metastasis-depend-Neoplasms', 'Liver Cirrhosis-depend-Neoplasms', 'Aortic Aneurysm, Abdominal-develop-Renal Insufficiency', 'Death-caused-Renal Insufficiency', 'Cough-become-Neoplasms', 'Fistula-become-Neoplasms', 'Blood Coagulation Disorders, Inherited-associated-Death', 'Death-associated-Blood Coagulation Disorders, Inherited', 'Hypotension-occur-Aneurysm, Ruptured', 'Pulmonary Disease, Chronic Obstructive-lead-Pulmonary Arterial Hypertension', 'Shock-occur-Aneurysm, Ruptured', 'Anemia, Hemolytic-associated-Death', 'Death-associated-Anemia, Hemolytic', 'Status Asthmaticus-associated-Death', 'Death-associated-Status Asthmaticus', 'Shock-occur-Hypotension', 'Diabetes Mellitus-associated-Cystic Fibrosis', 'Cystic Fibrosis-associated-Diabetes Mellitus', 'Neoplasms-associated-Glioma', 'Glioma-associated-Neoplasms', 'Astrocytoma-promote-Brain Diseases', 'Hypotension-take-Fractures, Bone', 'Liver Cirrhosis, Alcoholic-associated-Death', 'Death-associated-Liver Cirrhosis, Alcoholic', 'Immunologic Deficiency Syndromes-manifest-Osteoporosis', 'Cardiovascular Diseases-driven-Coronary Artery Disease', 'Flushing-use-Muscle Hypertonia', 'Flushing-decrease-Ductus Arteriosus, Patent', 'Muscle Hypertonia-decrease-Ductus Arteriosus, Patent', 'Death-observed-Graft vs Host Disease', 'Huntington Disease-live-Death', 'Heart Diseases-include-Hip Fractures', 'Aortic Valve Stenosis-increase-Death', 'Hip Fractures-compared-Hypertension, Pulmonary', 'Chronic Disease-tend-Death', 'Heart Diseases-present-Shock', 'Gout-associated-Crystal Arthropathies', 'Crystal Arthropathies-associated-Gout', 'Gout-induce-Inflammation', 'Crystal Arthropathies-induce-Inflammation', 'Hyperuricemia-induce-Inflammation', 'Sensation Disorders-associated-Fabry Disease', 'Fabry Disease-associated-Sensation Disorders', 'Genetic Diseases, Inborn-cystic-Cystic Fibrosis', 'Lung Diseases-cystic-Cystic Fibrosis', 'Obesity-influence-Non-alcoholic Fatty Liver Disease', 'Parkinson Disease-used-Osteoporotic Fractures', 'Metabolic Syndrome-influence-Non-alcoholic Fatty Liver Disease', 'Death-rose-Drug Overdose', 'Death-rose-Liver Diseases, Alcoholic', 'Death-rose-Cardiovascular Diseases', 'Death-receive-Hyperlipidemias', 'Metabolic Syndrome-found-Death', 'Death-receive-Diabetes Mellitus', 'Leukemia, Myelogenous, Chronic, BCR-ABL Positive-fail-Leukemia', 'Nose Diseases-lead-Pulmonary Atresia', 'Seizures-seen-Vision, Low', 'Carcinoma, Hepatocellular-diagnose-Exanthema Subitum', 'Neoplasms-diagnose-Exanthema Subitum', 'Exanthema Subitum-diagnose-Death', 'Chronic Disease-reduce-Cardiovascular Diseases', 'Carcinoma, Squamous Cell-preceded-Neoplasms', 'Amyloidosis-debilitate-Heart Diseases', 'Carcinoma, Squamous Cell-make-Neoplasms', 'Coronary Artery Disease-diagnosed-Chest Pain', 'Dementia-require-Pneumonia', 'HIV Infections-convert-Chronic Disease', 'HIV Infections-convert-Kidney Diseases', 'Kidney Diseases-remain-Glomerulonephritis', 'Kidney Diseases-remain-Hepatitis C', 'Glomerulonephritis-remain-Hepatitis C', 'Rhabdomyosarcoma-present-Cranial Nerve Diseases', 'Cranial Nerve Diseases-present-Mastoiditis', 'Lymphoma, Non-Hodgkin-remain-Death', 'Nervous System Diseases-include-Brain Injuries', 'Nervous System Diseases-lead-Cerebral Palsy', 'Nervous System Diseases-include-Multiple Sclerosis', 'Nervous System Diseases-lead-Multiple Sclerosis', 'Brain Injuries-lead-Cerebral Palsy', 'Brain Injuries-lead-Multiple Sclerosis', 'Sleep Wake Disorders-induce-Hypoxia', 'Sleep Wake Disorders-induce-Hypercapnia', 'Neoplasms-screened-Infections', 'Muscle Weakness-accompany-Fatigue', 'Paraneoplastic Syndromes-occur-Small Cell Lung Carcinoma', 'Syncope-fall-Nervous System Diseases', 'Dry Eye Syndromes-discuss-Nervous System Diseases', 'Hypotension, Orthostatic-identify-Syncope', 'Dry Eye Syndromes-combined-Nervous System Diseases', 'Nervous System Diseases-related-Dry Eye Syndromes', 'Neuralgia-related-Dry Eye Syndromes', 'Chronic Pain-related-Dry Eye Syndromes', 'Peripheral Nervous System Diseases-related-Dry Eye Syndromes', 'Central Nervous System Diseases-related-Dry Eye Syndromes', 'Death-caused-Lung Diseases', 'Movement Disorders-associated-Retinal Degeneration', 'Retinal Degeneration-associated-Movement Disorders', 'Heredodegenerative Disorders, Nervous System-range-Poliomyelitis', 'Leukemia, Myelogenous, Chronic, BCR-ABL Positive-develop-Androgen-Insensitivity Syndrome', 'Cystic Fibrosis-progress-Liver Diseases', 'Aortic Aneurysm, Abdominal-face-Rupture', 'Death-associated-Paresis', 'Paresis-associated-Death', 'Cystic Fibrosis-referred-Lung Diseases', 'Psoriasis-develop-Arthritis, Psoriatic', 'Death-reflect-Aortic Valve Insufficiency', 'Death-lost-Diabetes Mellitus', 'Huntington Disease-find-Neurodegenerative Diseases', 'Heart Diseases-observed-Death', 'Huntington Disease-hampered-Arthritis, Rheumatoid', 'Endometrial Neoplasms-associate-Hemorrhage', 'Hemorrhage-associate-Endometrial Neoplasms', 'Hypoxia-emerge-Neoplasms', 'Hypoxia-promote-Neoplasms', 'Neoplasms-linked-Hypoxia', 'Hypoxia-linked-Neoplasms', 'Hypoxia-contribute-Neoplasms', 'Amyotrophic Lateral Sclerosis-lead-Death', 'Cystic Fibrosis-characterised-Infections', 'Seizures-optimize-Malaria', 'Cystic Fibrosis-attributed-Hypoxia', 'Colorectal Neoplasms-result-Intestinal Neoplasms', 'Colorectal Neoplasms-result-Neoplasms', 'Intestinal Neoplasms-reduce-Neoplasms', 'Inflammation-lead-Periodontitis', 'Cardio-Renal Syndrome-increase-Death', 'Cardiovascular Diseases-challenge-Hemophilia A', 'Cardiovascular Diseases-associated-Hemorrhage', 'Hemorrhage-associated-Cardiovascular Diseases', 'Coronary Artery Disease-challenge-Hemophilia A', 'Acute Coronary Syndrome-challenge-Hemophilia A', 'Metabolic Diseases-observed-Adrenal Insufficiency', 'Death-directed-Chronic Disease', 'Mitral Valve Insufficiency-surgeons--in-Ventricular Dysfunction', 'Obesity-pave-Atherosclerosis', 'Plasmacytoma-appear-Multiple Myeloma', 'Turner Syndrome-cause-Death', 'Pain-result-Neurodegenerative Diseases', 'Hypercalcemia-result-Neoplasms', 'Hypercalcemia-result-Neurodegenerative Diseases', 'Fractures, Bone-result-Neurodegenerative Diseases', 'Infections-associated-Coinfection', 'Coinfection-associated-Infections', 'Arthritis, Rheumatoid-recognized-Cardiovascular Diseases', 'Arthritis, Rheumatoid-recognized-Death', 'Cardiovascular Diseases-recognized-Death', 'Arthritis, Rheumatoid-account-Cardiovascular Diseases', 'Arthritis, Rheumatoid-account-Death', 'Death-decrease-Inflammation', 'Arthritis, Rheumatoid-control-Inflammation', 'Inflammation-control-IgA Vasculitis', 'Critical Illness-result-Peripheral Arterial Disease', 'Glaucoma-adjusted-Death', 'Obesity-identified-Diabetes Mellitus, Type 2', 'Death-determine-Glaucoma', 'Death-develop-Glaucoma', 'Obesity-identified-Cardiovascular Diseases', 'Polycystic Ovary Syndrome-identified-Diabetes Mellitus, Type 2', 'Polycystic Ovary Syndrome-identified-Cardiovascular Diseases', 'Death-initiate-Glaucoma', 'Pain-include-Critical Illness', 'Liver Diseases-decompensate-Fibrosis', 'Carcinoma, Hepatocellular-decompensate-Fibrosis', 'Osteoporosis-become-Obesity', 'Osteoporosis-increase-Obesity', 'Osteoporosis-become-Diabetes Mellitus', 'Osteoporosis-become-Liver Diseases', 'Osteoporosis-become-Kidney Diseases', 'Thyroid Carcinoma, Anaplastic-account-Death', 'Thyroid Neoplasms-account-Death', 'Neoplasms-admitted-Pericardial Effusion', 'Eye Infections, Fungal-constitute-Lymphoma, T-Cell, Cutaneous', 'Substance-Related Disorders-contribute-Cardiovascular Diseases', 'Pain Insensitivity, Congenital-associated-Hyperesthesia', 'Hyperesthesia-associated-Pain Insensitivity, Congenital', 'Trigeminal Nerve Diseases-manifest-Hypesthesia', 'Death-identified-Diabetes Mellitus', 'Trigeminal Nerve Diseases-pose-Wounds and Injuries', 'Trigeminal Nerve Diseases-pose-Neoplasms', 'Trigeminal Nerve Diseases-pose-Demyelinating Diseases', 'Infections-trigger-Anemia, Aplastic', 'Infections-cause-Red-Cell Aplasia, Pure', 'Infections-cause-Anemia', 'Neoplasm Metastasis-include-Venous Thrombosis', 'Neoplasm Metastasis-avoid-Venous Thrombosis', 'Pain-reduce-Hypercalcemia', 'Neoplasm Metastasis-include-Postpartum Hemorrhage', 'Neoplasm Metastasis-associated-Postpartum Hemorrhage', 'Postpartum Hemorrhage-associated-Neoplasm Metastasis', 'Postpartum Hemorrhage-include-Venous Thrombosis', 'Pain-improve-Neoplasms', 'Autoimmune Diseases-relapse-Polychondritis, Relapsing', 'Inflammation-relapse-Polychondritis, Relapsing', 'Eye Infections, Fungal-present-Skin Diseases, Eczematous', 'Airway Obstruction-occur-Neoplasms', 'Hypertension, Pulmonary-recognized-Lung Diseases', 'Lung Diseases-associated-Rheumatic Diseases', 'Rheumatic Diseases-associated-Lung Diseases', 'Lung Diseases, Interstitial-associated-Rheumatic Diseases', 'Rheumatic Diseases-associated-Lung Diseases, Interstitial', 'Prostatic Neoplasms-associated-HIV Infections', 'HIV Infections-associated-Prostatic Neoplasms', 'Glioblastoma-comprise-Brain Neoplasms', 'Myotonic Dystrophy-decrease-Hypertension', 'Myotonic Dystrophy-decrease-Hypertriglyceridemia', 'Hypertriglyceridemia-decrease-Hypertension', 'Glioma-include-Astrocytoma', 'Glioma-include-Glioblastoma', 'Sexual Dysfunction, Physiological-persist-Breast Neoplasms', 'Pelvic Neoplasms-cause-Pain', 'Pelvic Neoplasms-cause-Sensation Disorders', 'Leigh Disease-characterized-Acidosis, Lactic', 'Leigh Disease-present-Muscle Hypotonia', 'Growth Disorders-associated-Death', 'Death-associated-Growth Disorders', 'Acidosis, Lactic-present-Muscle Hypotonia', 'Glioblastoma-result-Neoplasms', 'Glioblastoma-result-Brain Neoplasms', 'Death-decline-Cerebrovascular Disorders', 'Death-decline-End Stage Liver Disease', 'Death-decline-Fibrosis', 'Congenital Abnormalities-account-Death', 'Osteogenesis Imperfecta-contribute-Death', 'Osteogenesis Imperfecta-cause-Death', 'Osteogenesis Imperfecta-contribute-Intracranial Hemorrhages', 'Osteogenesis Imperfecta-contribute-Respiratory Tract Diseases', 'Osteogenesis Imperfecta-contribute-Heart Failure', 'Polyps-undergo-Adenomatous Polyposis Coli', 'Pain, Postoperative-related-Dementia, Vascular', 'Pain, Postoperative-related-Brain Ischemia', 'Pain, Postoperative-related-Arterial Occlusive Diseases', 'Aneurysm-restricted-Neurologic Manifestations', 'Aneurysm-concerned-Neurologic Manifestations', 'Phenylketonurias-seen-Metabolism, Inborn Errors', 'Phenylketonurias-cause-Intellectual Disability', 'Metabolism, Inborn Errors-cause-Intellectual Disability', 'Neoplasms-improve-Breast Neoplasms', 'Neoplasms-bear-Death', 'Breast Neoplasms-considered-Death', 'Neoplasms-co-express-Breast Neoplasms', 'Porokeratosis-develop-Carcinoma, Squamous Cell', 'Carcinoma, Squamous Cell-found-Adenocarcinoma', 'Neoplasms-implanted-Leukemia L1210', 'Death-caused-Death, Sudden', 'Death-classified-Hypertension', 'Death-classified-Nephritis', 'Hemolysis-show-Cystic Fibrosis', 'Death-classified-Kidney Diseases', 'Cystic Fibrosis-associate-Hepatitis E', 'Hepatitis E-associate-Cystic Fibrosis', 'Fractures, Bone-increase-Hemophilia A', 'Stomach Neoplasms-selected-Neoplasms', 'Inflammation-implicated-Death', 'Schistosomiasis-attributed-Death', 'Abetalipoproteinemia-provide-Genetic Diseases, Inborn', 'Inflammation-set-Neurodegenerative Diseases', 'Neurodegenerative Diseases-live-Multiple Sclerosis', 'Lupus Erythematosus, Systemic-understood-Inflammation', 'Neoplasms-ameliorate-Genetic Diseases, Inborn', 'Hemorrhage-caused-Peptic Ulcer', 'Hypertension-characterized-Inflammation', 'HIV Infections-followed-Hemorrhage', 'Neoplasms-harbor-Iatrogenic Disease', 'HIV Infections-followed-Cardiovascular Diseases', 'HIV Infections-followed-Liver Diseases', 'HIV Infections-followed-Neoplasms', 'Diabetic Nephropathies-preexist-Diabetes Mellitus, Type 2', 'Carcinoma, Hepatocellular-extend-Drug-Related Side Effects and Adverse Reactions', 'Neoplasms-adapt-Seizures', 'Neoplasms-extend-Drug-Related Side Effects and Adverse Reactions', 'Death-examine-Arthritis, Rheumatoid', 'Arthritis, Rheumatoid-combined-Lung Diseases, Interstitial', 'Genetic Diseases, Inborn-associated-Infections', 'Infections-associated-Genetic Diseases, Inborn', 'Lung Diseases-characterized-Cerebrovascular Disorders', 'HIV Infections-lead-Lung Diseases', 'Endometriosis-cause-Dystonia', 'Endometriosis-cause-Dysmenorrhea', 'Endometriosis-cause-Dyspareunia', 'Endometriosis-cause-Constipation', 'Endometriosis-cause-Dysuria', 'Endometriosis-cause-Pelvic Pain', 'Dysmenorrhea-include-Dystonia', 'Dyspareunia-include-Dystonia', 'Constipation-include-Dystonia', 'Dysuria-include-Dystonia', 'Pelvic Pain-include-Dystonia', 'Obesity-increase-Endometrial Neoplasms', 'Huntington Disease-mitigate-Nerve Degeneration', 'Respiratory Insufficiency-ensue-Death', 'Hypertension, Pulmonary-complicate-Pneumonia', 'Hypertension, Pulmonary-appear-Lung Diseases', 'Hypertension, Pulmonary-terminated-Death', 'Pneumonia-terminated-Death', 'Critical Illness-reduce-Weight Gain', 'Leukoencephalopathies-treat-Hypothermia', 'Hepatolenticular Degeneration-induce-Liver Failure', 'Myotonic Dystrophy-estimated-Diabetes Mellitus', 'Neoplasms-provide-Pain', 'Neoplasms-provide-Fatigue', 'Cardiovascular Diseases-compared-Obesity', 'Neoplasm Metastasis-come-Neoplasms', 'Genetic Diseases, Inborn-attributed-Neoplasms', 'Neoplasms-associated-Pheochromocytoma', 'Pheochromocytoma-associated-Neoplasms', 'Pheochromocytoma-suffer-Cerebral Infarction', 'Neoplasms-identify-Pheochromocytoma', 'Heart Failure-refer-Heart Diseases', 'Heart Failure-refer-Hypotension', 'Heart Failure-refer-Cardiomyopathies', 'Marfan Syndrome-characterized-Heart Diseases', 'Marfan Syndrome-characterized-Death', 'Marfan Syndrome-characterized-Heart Failure', 'Short Bowel Syndrome-represent-Death', 'Osteoporotic Fractures-become-Wounds and Injuries', 'Fractures, Bone-quantify-Osteoporosis', 'Osteoporotic Fractures-alleviate-Osteoporosis', 'Death-arise-Substance-Related Disorders', 'Alcoholism-explain-Death', 'Rhabdoid Tumor-distinguished-Neoplasms', 'Death-result-Substance-Related Disorders', 'Rhabdoid Tumor-defined-Sarcoma', 'Intracranial Aneurysm-consider-Rupture', 'Metabolism, Inborn Errors-lead-Neurodegenerative Diseases', 'Metabolism, Inborn Errors-lead-Death', 'Heart Diseases-develop-Atrial Fibrillation', 'Heart Diseases-develop-Hypertension', 'Heart Diseases-develop-Diabetes Mellitus', 'Heart Diseases-develop-Coronary Artery Disease', 'Heart Diseases-evolve-Dementia', 'Motor Neuron Disease-result-Death', 'Leukodystrophy, Metachromatic-cause-Demyelinating Diseases', 'Leukodystrophy, Metachromatic-cause-Inflammation', 'Leukodystrophy, Metachromatic-lead-Nervous System Diseases', 'Demyelinating Diseases-associate-Inflammation', 'Inflammation-associate-Demyelinating Diseases', 'Demyelinating Diseases-associate-Pelizaeus-Merzbacher Disease', 'Pelizaeus-Merzbacher Disease-associate-Demyelinating Diseases', 'Demyelinating Diseases-observe-Pelizaeus-Merzbacher Disease', 'Demyelinating Diseases-lead-Nervous System Diseases', 'Inflammation-lead-Nervous System Diseases', 'Inflammation-observe-Pelizaeus-Merzbacher Disease', 'Pelizaeus-Merzbacher Disease-treat-Polyneuropathies', 'Medulloblastoma-screened-Basal Cell Nevus Syndrome', 'Basal Cell Nevus Syndrome-known-Neurocutaneous Syndromes', 'Hypotension-use-Diabetes Mellitus', 'Medulloblastoma-avoided-Basal Cell Nevus Syndrome', 'Medulloblastoma-avoided-Neoplasms', 'Alzheimer Disease-lack-Dementia', 'Colorectal Neoplasms, Hereditary Nonpolyposis-benefit-Colorectal Neoplasms', 'Neoplasms-treat-Neoplasm Metastasis', 'Anemia-compare-Fibrosis', 'Anemia-reduce-Fibrosis', 'Communicable Diseases-constitute-Death', 'Anemia-compare-Splenomegaly', 'Anemia-enhance-Splenomegaly', 'Pneumonia-cause-Invasive Fungal Infections', 'Carcinoma, Hepatocellular-listed-Death', 'Death-reduce-Chagas Disease', 'Death-incorporate-Neoplasms', 'Skin Diseases-characterized-Genetic Diseases, Inborn', 'Arteriovenous Malformations-presented-Rupture', 'Pleural Effusion, Malignant-found-Lung Neoplasms', 'Neoplasms-remain-Pleural Effusion, Malignant', 'Embolism-prevent-Intracranial Hemorrhages', 'Chronic Disease-result-Coinfection', 'Heart Septal Defects, Atrial-reduced-Ventricular Dysfunction', 'Death-cause-Cystic Fibrosis', 'Tooth Loss-known-Periodontitis', 'Tooth Loss-known-Fractures, Bone', 'Death-include-Congenital Abnormalities', 'Death-include-Infant, Newborn, Diseases', 'Low Back Pain-include-Death', 'Osteoarthritis-include-Death', 'Telangiectasia, Hereditary Hemorrhagic-protected-Neoplasms', 'Colorectal Neoplasms-modified-Telangiectasia, Hereditary Hemorrhagic', 'Paralysis-induced-Movement Disorders', 'Skin Neoplasms-investigate-Crohn Disease', 'Aortic Coarctation-account-Heart Diseases', 'Neoplasms-underline-Infections', 'Acquired Immunodeficiency Syndrome-overcome-Opportunistic Infections', 'Acquired Immunodeficiency Syndrome-overcome-Sarcoma, Kaposi', 'HIV Infections-convey-Liver Diseases', 'Neoplasms-minimize-Hypogonadism', 'Neoplasms-affect-Infertility, Female', 'Hypogonadism-make-Infertility, Female', 'Tachycardia, Supraventricular-facilitate-Arrhythmias, Cardiac', 'Heart Failure-assessed-Stroke', 'Genetic Diseases, Inborn-involve-Neoplasms', 'Neoplasms-involve-Drug-Related Side Effects and Adverse Reactions', 'Genetic Diseases, Inborn-predict-Drug-Related Side Effects and Adverse Reactions', 'Osteoarthritis-used-Obesity', 'Osteoarthritis-represent-Obesity', 'Cerebral Hemorrhage-offset-Cardiovascular Diseases', 'Obesity-avert-Coronary Artery Disease', 'Obesity-avert-Diabetes Mellitus', 'Seizures-emerge-Cardiovascular Diseases', 'Seizures-emerge-Death', 'Seizures-complicated-Obesity', 'Cardiovascular Diseases-complicated-Obesity', 'Death-complicated-Obesity', 'Fibrosis-lead-Pneumonia', 'Osteopetrosis-characterised-Bone Resorption', 'Osteopetrosis-characterised-Bone Diseases', 'Hypertrophy-arise-Hypotension', 'Hypertrophy-arise-Heart Diseases', 'Cardiomyopathies-characterized-Cardiomegaly', 'Central Nervous System Diseases-associated-Small Cell Lung Carcinoma', 'Small Cell Lung Carcinoma-associated-Central Nervous System Diseases', 'Hypertrophy-arise-Heart Failure', 'Hyperkinesis-characterized-Cardiomegaly', 'Paraneoplastic Syndromes, Nervous System-associated-Small Cell Lung Carcinoma', 'Small Cell Lung Carcinoma-associated-Paraneoplastic Syndromes, Nervous System', 'Hypertrophy-arise-Cardiomyopathies', 'Tetany-provide-Neurodegenerative Diseases', 'HIV Infections-associated-Thrombosis', 'Thrombosis-associated-HIV Infections', 'Ischemia-improved-Seizures', 'Cerebellar Ataxia-show-Growth Disorders', 'Cerebellar Ataxia-develop-Cataract', 'Growth Disorders-develop-Cataract', 'Pigmentation Disorders-comprise-Neoplasms', 'Epilepsy, Temporal Lobe-disable-Seizures', 'Epilepsy, Temporal Lobe-reduce-Death', 'Seizures-reduce-Death', 'Death-observed-HIV Infections', 'Hemophilia A-acquire-Hemorrhage', 'HIV Infections-observed-Hemophilia A', 'Ischemia-shown-Stroke', 'Cardiovascular Diseases-become-Malnutrition', 'Aneurysm-include-Death', 'Aneurysm-cause-Death', 'Pancreatitis-include-Cystic Fibrosis', 'Prostatic Neoplasms-extend-Neoplasms', 'Prostatic Neoplasms-become-Infections', 'Tuberculosis, Pulmonary-resemble-Sarcoma, Kaposi', 'HIV Infections-compared-Chronic Disease', 'HIV Infections-compared-Cardiovascular Diseases', 'HIV Infections-compared-Diabetes Mellitus', 'Cardiovascular Diseases-compare-Hypertension', 'Hypertension-compare-Myocardial Infarction', 'Infections-cause-Bone Marrow Failure Disorders', 'Anemia-induced-Infections', 'Neoplasms-include-Mastocytosis, Systemic', 'Infections-include-Mastocytosis, Systemic', 'Neoplasms-increase-Colorectal Neoplasms', 'Neoplasms-increase-Colitis, Ulcerative', 'Adenocarcinoma-manifested-Superior Vena Cava Syndrome', 'Sick Sinus Syndrome-increase-Death', 'Ventricular Remodeling-regarded-Heart Failure', 'Carcinoid Tumor-undergo-Neoplasms', 'Neoplasms-threaten-Ischemia', 'Carcinoid Tumor-benefit-Neoplasms', 'Carcinoma, Ductal-confirmed-Neoplasms', 'Acquired Immunodeficiency Syndrome-result-Cardiovascular Diseases', 'Death-required-Jaundice', 'Dementia, Vascular-recognized-Peptic Ulcer', 'Hypertension, Pulmonary-associated-Heart Defects, Congenital', 'Heart Defects, Congenital-associated-Hypertension, Pulmonary', 'Aneurysm-associated-Antiphospholipid Syndrome', 'Antiphospholipid Syndrome-associated-Aneurysm', 'Aneurysm-associated-Collagen Diseases', 'Collagen Diseases-associated-Aneurysm', 'Aneurysm-associated-Schistosomiasis', 'Schistosomiasis-associated-Aneurysm', 'Aneurysm-associated-Heart Defects, Congenital', 'Heart Defects, Congenital-associated-Aneurysm', 'Melanoma-sacrificed-Signs and Symptoms, Respiratory', 'Neoplasms-obtained-Small Cell Lung Carcinoma', 'Death-caused-Mycoses', 'Epilepsy-maximize-Seizures', 'Cystic Fibrosis-experience-Diabetes Mellitus', 'Reperfusion Injury-elicit-Arrhythmias, Cardiac', 'Reperfusion Injury-elicit-Infarction', 'Heart Diseases-reflect-Coronary Artery Disease', 'Heart Diseases-established-Coronary Artery Disease', 'Aortic Aneurysm-indicate-Marfan Syndrome', 'Kidney Diseases, Cystic-increase-Kidney Neoplasms', 'Fractures, Bone-offer-Death', 'Holoprosencephaly-considered-Abnormalities, Drug-Induced', 'Mucopolysaccharidosis II-induced-Atherosclerosis', 'Thrombosis-prevent-Angina, Unstable', 'Prostatic Neoplasms-accept-Erectile Dysfunction', 'Hypersplenism-associated-Sepsis', 'Sepsis-associated-Hypersplenism', 'Neoplasms-dialyse-Death', 'Malaria, Falciparum-use-Infections', 'Hemophilia A-characterized-Hemophilia B', 'Hemorrhage-characterized-Hemophilia B', 'Hemophilia A-considered-Thrombosis', 'Hemophilia A-protect-Thrombosis', 'HIV Infections-underlie-Pulmonary Disease, Chronic Obstructive', 'Heart Failure-base-Heart Valve Diseases', 'Nail-Patella Syndrome-increase-Dementia', 'Nail-Patella Syndrome-seen-Dementia', 'Dementia-comprise-Brain Diseases', 'Acromegaly-consist-Death', 'Hearing Loss-live-Dementia', 'Anemia-known-Stroke', 'Alzheimer Disease-individuated-Inflammation', 'Renal Insufficiency, Chronic-enable-Diabetes Mellitus', 'Heart Failure-enable-Diabetes Mellitus', 'Hemolysis-result-Ischemia', 'Death-estimated-Colorectal Neoplasms', 'Death-suffer-Pneumoconiosis', 'Death-coined-Obesity', 'Exanthema-associated-Fever', 'Fever-associated-Exanthema', 'Bone Neoplasms-related-Hereditary Angioedema Type III', 'Neoplasms-travel-Neoplasm Metastasis', 'Parkinson Disease-infected-HIV Infections', 'Parkinson Disease-diagnosed-HIV Infections', 'Fractures, Bone-observed-Bone Diseases, Metabolic', 'Cardiomyopathy, Hypertrophic-seen-Genetic Diseases, Inborn', 'Cerebral Palsy-differ-Fractures, Bone', 'Cardiomyopathy, Hypertrophic-live-Death, Sudden, Cardiac', 'Heart Diseases-treat-Cardiomyopathy, Hypertrophic', 'Congenital, Hereditary, and Neonatal Diseases and Abnormalities-defined-Abnormalities, Drug-Induced', 'Diabetic Nephropathies-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-Diabetic Nephropathies', 'Chronic Disease-promote-Inflammation', 'Obesity-observed-Diabetes Mellitus', 'Neurologic Manifestations-promote-Cardiovascular Diseases', 'Cerebrovascular Disorders-enrolled-Atherosclerosis', 'Ulcer-prevent-Osteoporosis', 'Neoplasms-exist-Death', 'Death-increased-Endocrine System Diseases', 'Hidradenitis Suppurativa-comprise-Necrosis', 'Hidradenitis Suppurativa-include-Cardiovascular Diseases', 'Hidradenitis Suppurativa-designated-Acne Vulgaris', 'Acne Vulgaris-designated-Inflammation', 'Cystic Fibrosis-increase-Digestive System Neoplasms', 'Cystic Fibrosis-increase-Leukemia, Lymphoid', 'Cystic Fibrosis-increase-Testicular Neoplasms', 'Lipodystrophy, Congenital Generalized-characterized-Atrophy', 'Cystic Fibrosis-slow-Death', 'Leukemia, Myelogenous, Chronic, BCR-ABL Positive-include-Neoplasms', 'Amenorrhea-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-Amenorrhea', 'Primary Ovarian Insufficiency-experience-Rhinitis, Vasomotor', 'Muscle Hypotonia-lead-Death', 'Glaucoma-identify-Ocular Hypertension', 'Diabetic Foot-lead-Death', 'Diabetes Mellitus-lead-Death', 'Granulomatous Disease, Chronic-characterized-Infections', 'Spinal Cord Diseases-mimic-Tuberculosis', 'Pneumonia-mimic-Tuberculosis', 'Neoplasms-investigate-Diabetes Mellitus, Type 2', 'Pancreatic Neoplasms-investigate-Diabetes Mellitus, Type 2', 'Drug-Related Side Effects and Adverse Reactions-measure-Death', 'Thrombosis-reported-Neoplasms', 'Thrombosis-caused-Neoplasms', 'Thrombosis-reported-Death', 'Thrombosis-caused-Death', 'Thrombosis-expose-Hemorrhage', 'Thrombosis-reported-Neoplasm Metastasis', 'Thrombosis-reported-Pregnancy Complications, Infectious', 'Neoplasms-reported-Neoplasm Metastasis', 'Neoplasms-reported-Pregnancy Complications, Infectious', 'Sarcoma-target-Neoplasms', 'Hemangiosarcoma-study-Sarcoma', 'Sarcoma-differ-Neoplasms', 'Polycystic Kidney Diseases-used-Hypertension', 'Ataxia Telangiectasia-characterized-Ataxia', 'Telangiectasis-characterized-Ataxia Telangiectasia', 'Neoplasms-consider-Colorectal Neoplasms', 'Huntington Disease-correlate-Death', 'Tertiary Lymphoid Structures-target-Neoplasms', 'Drug-Related Side Effects and Adverse Reactions-make-Osteoarthritis', 'Graft vs Host Disease-assess-Stroke', 'Graft vs Host Disease-assess-Heart Failure', 'Graft vs Host Disease-assess-Hypertension', 'Graft vs Host Disease-assess-Diabetes Mellitus', 'Graft vs Host Disease-assess-Ischemia', 'Graft vs Host Disease-assess-Aneurysm', 'Stroke-assess-Heart Failure', 'Stroke-assess-Hypertension', 'Hemorrhage-offset-Embolism', 'Stroke-assess-Diabetes Mellitus', 'Stroke-assess-Ischemia', 'Stroke-assess-Aneurysm', 'Death-develop-Graft vs Host Disease', 'Esophageal Neoplasms-rule-Neoplasms', 'Testicular Neoplasms-diagnosed-Neoplasms', 'Multiple Myeloma-decrease-Breast Neoplasms', 'Multiple Myeloma-decrease-Neoplasm Metastasis', 'Hematologic Neoplasms-cause-Bone Diseases', 'Neoplasms-considered-Sarcoma', 'Hyperopia-develop-Myopia', 'Neoplasms-block-Breast Neoplasms', 'Neoplasms-block-Acro-Osteolysis', 'Lung Neoplasms-demonstrate-Death', 'Primary Myelofibrosis-distinguished-Thrombocythemia, Essential', 'Thrombocytosis-associated-von Willebrand Diseases', 'von Willebrand Diseases-associated-Thrombocytosis', 'Thrombocytosis-associated-Hemorrhage', 'Hemorrhage-associated-Thrombocytosis', 'Anorexia-experience-Hyperphagia', 'Thrombocythemia, Essential-include-Thrombocytosis', 'Thrombocythemia, Essential-include-Primary Myelofibrosis', 'Thrombocythemia, Essential-include-Leukocytosis', 'Thrombosis-include-Thrombocythemia, Essential', 'Leukocytosis-include-Polycythemia Vera', 'Thrombosis-include-Polycythemia Vera', 'Death-identify-Factor X Deficiency', 'Xanthomatosis-signalise-Dyslipidemias', 'Xanthomatosis-associated-Paraproteinemias', 'Paraproteinemias-associated-Xanthomatosis', 'Xanthomatosis-implicate-Pancreatitis', 'Xanthomatosis-associated-Lymphoproliferative Disorders', 'Lymphoproliferative Disorders-associated-Xanthomatosis', 'Xanthomatosis-implicate-Diabetes Mellitus, Type 2', 'Hyperlipoproteinemia Type III-associated-Xanthomatosis', 'Xanthomatosis-associated-Hyperlipoproteinemia Type III', 'Hypertriglyceridemia-implicate-Pancreatitis', 'Hyperlipoproteinemia Type II-shown-Xanthomatosis', 'Hyperlipoproteinemia Type III-associated-Paraproteinemias', 'Paraproteinemias-associated-Hyperlipoproteinemia Type III', 'Hypertriglyceridemia-implicate-Diabetes Mellitus, Type 2', 'Hyperlipoproteinemia Type III-associated-Lymphoproliferative Disorders', 'Lymphoproliferative Disorders-associated-Hyperlipoproteinemia Type III', 'Xanthomatosis-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-Xanthomatosis', 'Xanthomatosis-connected-Communicable Diseases', 'Neoplasms-reported-Endometrial Neoplasms', 'Cystic Fibrosis-encountered-Diabetes Mellitus', 'Renal Insufficiency, Chronic-marked-Death', 'Cardiovascular Diseases-lead-Angina Pectoris', 'Kidney Diseases-become-HIV Infections', 'Echinococcosis, Hepatic-associated-Echinococcosis', 'Echinococcosis-associated-Echinococcosis, Hepatic', 'Renal Tubular Transport, Inborn Errors-include-Kidney Diseases', 'Hamartoma Syndrome, Multiple-cooperate-Neoplasms', 'Drug Hypersensitivity-include-Blood Coagulation Disorders', 'Sepsis-include-Blood Coagulation Disorders', 'Bacteremia-include-Blood Coagulation Disorders', 'Hepatolenticular Degeneration-implant-Williams Syndrome', 'Williams Syndrome-implant-Atrioventricular Block', 'Hepatolenticular Degeneration-implant-Atrioventricular Block', 'Infections-followed-Cardiovascular Diseases', 'Death-followed-Cardiovascular Diseases', 'Uterine Retroversion-reduce-Inflammation', 'Pruritus-include-Headache Disorders, Secondary', 'Acquired Immunodeficiency Syndrome-suffering-Immunologic Deficiency Syndromes', 'Diabetes Mellitus, Type 2-tempered-Cardiovascular Diseases', 'Diabetes Mellitus, Type 2-accompanied-Hypoglycemia', 'Neoplasms-bear-Glioblastoma', 'Muscular Dystrophies-refer-Genetic Diseases, Inborn', 'Muscular Dystrophies-cause-Muscle Weakness', 'Genetic Diseases, Inborn-cause-Muscle Weakness', 'Ischemia-simulate-Neoplasms', 'Myocardial Infarction-compare-Diabetes Mellitus', 'Leukoencephalopathy, Progressive Multifocal-caused-Infections', 'Leukoencephalopathy, Progressive Multifocal-caused-Neoplasms', 'Leukoencephalopathy, Progressive Multifocal-caused-HIV Infections', 'Leukoencephalopathy, Progressive Multifocal-remain-Death', 'Neoplasms-exhibit-Small Cell Lung Carcinoma', 'Diabetes Mellitus, Type 1-found-Hypogonadism', 'Hearing Loss, Central-found-Hypogonadism', 'Dementia-produce-Alzheimer Disease', 'Alzheimer Disease-raise-Death', 'Alzheimer Disease-raise-Neoplasms', 'Death-raise-Neoplasms', 'Astrocytoma-encourage-Neoplasms', 'Astrocytoma-document-Drug-Related Side Effects and Adverse Reactions', 'Neoplasms-document-Drug-Related Side Effects and Adverse Reactions', 'Neoplasm Metastasis-lead-Neoplasms', 'Neoplasm Metastasis-become-Hypertension', 'Wounds and Injuries-produce-Puberty, Delayed', 'Epilepsy, Benign Neonatal-associated-Atherosclerosis', 'Atherosclerosis-associated-Epilepsy, Benign Neonatal', 'Epilepsy, Benign Neonatal-associated-Coronary Artery Disease', 'Coronary Artery Disease-associated-Epilepsy, Benign Neonatal', 'Genetic Diseases, Inborn-associated-Coronary Artery Disease', 'Coronary Artery Disease-associated-Genetic Diseases, Inborn', 'Death-identified-Fatigue', 'Hepatitis C-interrupt-HIV Infections', 'Hepatitis C, Chronic-increase-Fibrosis', 'Chemical and Drug Induced Liver Injury-increase-Fibrosis', 'Liver Diseases-accelerated-Hepatitis C', 'HIV Infections-accelerated-Hepatitis C', 'Hypertension, Pulmonary-suspected-Lung Diseases', 'Hypertension, Pulmonary-suspected-Thrombosis', 'Hepatitis C-seem-HIV Infections', 'Chemical and Drug Induced Liver Injury-seem-HIV Infections', 'Hypotension-associated-Thrombosis', 'Thrombosis-associated-Hypotension', 'Lung Diseases-associated-Thrombosis', 'Thrombosis-associated-Lung Diseases', 'Thrombosis-associated-Hypertension, Pulmonary', 'Hypertension, Pulmonary-associated-Thrombosis', 'Lung Diseases-underlie-Thrombosis', 'Hypertension, Pulmonary-underlie-Thrombosis', 'Pulmonary Heart Disease-underlie-Thrombosis', 'Death-decrease-Kidney Failure, Chronic', 'Kidney Failure, Chronic-assessed-Death', 'Lupus Nephritis-cause-Renal Insufficiency', 'Infections-deregulated-HIV Infections', 'Thrombocythemia, Essential-decrease-Thrombosis', 'Death-seen-Coronary Artery Disease', 'Death-seen-Stroke', 'Parathyroid Neoplasms-associated-Communicable Diseases', 'Communicable Diseases-associated-Parathyroid Neoplasms', 'Coronary Artery Disease-treat-Heart Diseases', 'Coronary Artery Disease-treat-Neoplasms', 'Carcinoma, Hepatocellular-depend-Neoplasms', 'Heart Diseases-treat-Neoplasms', 'Ischemia-associated-Weight Loss', 'Weight Loss-associated-Ischemia', 'Arthritis, Rheumatoid-regarded-Death', 'Leukemia-used-Neoplasms', 'Rupture-excised-Aortic Aneurysm', 'Death-continue-Airway Obstruction', 'Pleural Effusion-associated-Lung Neoplasms', 'Lung Neoplasms-associated-Pleural Effusion', 'Thrombocytopenia-induced-Arthritis, Rheumatoid', 'Thrombocytopenia-investigated-Arthritis, Rheumatoid', 'Obesity-considered-Hypertension', 'Obesity-preceded-Hyperplasia', 'Neoplasms-preceded-Hyperplasia', 'Death-examined-Shock', 'Death-examined-Respiratory Tract Diseases', 'Death-treated-Femoral Neck Fractures', 'Osteoarthritis-follow-Femoral Neck Fractures', 'Neoplasms-result-Apudoma', 'Growth Disorders-include-Werner Syndrome', 'Cataract-include-Werner Syndrome', 'Skin Diseases-include-Werner Syndrome', 'Osteoporosis-include-Werner Syndrome', 'Neoplasms-include-Werner Syndrome', 'Diabetes Mellitus-include-Werner Syndrome', 'Arteriosclerosis-include-Werner Syndrome', 'Apudoma-affected-Neoplasms', 'Anemia-appear-Bone Marrow Failure Disorders', 'Vertebrobasilar Insufficiency-ascribed-Atherosclerosis', 'Hemoglobinopathies-include-Anemia, Sickle Cell', 'Hemoglobinopathies-develop-Cholelithiasis', 'Hemoglobinopathies-develop-Cholecystitis', 'Hemoglobinopathies-suffer-Splenic Infarction', 'Cholelithiasis-suffer-Splenic Infarction', 'Cholecystitis-suffer-Splenic Infarction', 'Death-occur-Peptic Ulcer', 'Obesity-support-Inflammation', 'Mastocytosis, Systemic-associated-Metabolic Syndrome', 'Metabolic Syndrome-associated-Mastocytosis, Systemic', 'Cardiovascular Diseases-undergo-Neoplasms', 'Catastrophic Illness-predispose-Aortic Aneurysm', 'Epilepsies, Partial-evolve-Seizures', 'Lung Neoplasms-represent-Death', 'Leukemia, Myelogenous, Chronic, BCR-ABL Positive-develop-Chronic Disease', 'Leukemia, Myelogenous, Chronic, BCR-ABL Positive-develop-Neoplasms', 'Neoplasms-ruine-Drug-Related Side Effects and Adverse Reactions', 'Aneurysm-infect-Infections', 'Infertility, Female-include-Polycystic Ovary Syndrome', 'Pulmonary Arterial Hypertension-remain-Communicable Diseases', 'Cardiovascular Diseases-link-Communicable Diseases', 'Hypothermia-undergo-Acute Kidney Injury', 'Death-related-Hypothermia', 'Communicable Diseases-increase-Respiratory Tract Infections', 'Melanoma-ende-Neoplasm Metastasis', 'Eye Neoplasms-ende-Neoplasm Metastasis', 'Obesity-suffer-Myotonic Dystrophy', 'Death-pertain-Pulmonary Embolism', 'Death-pertain-Stroke', 'Muscular Dystrophy, Duchenne-identified-Neuromuscular Diseases', 'Muscular Dystrophy, Duchenne-identified-Respiratory Insufficiency', 'Death-offset-Diabetes Mellitus', 'Death-offset-Metabolic Diseases', 'Heart Diseases-offset-Death', 'Heart Diseases-offset-Diabetes Mellitus', 'Heart Diseases-offset-Metabolic Diseases', 'Embolism-offset-Death', 'Embolism-offset-Diabetes Mellitus', 'Embolism-offset-Metabolic Diseases', 'Heart Diseases-followed-Respiratory Tract Diseases', 'Parasitic Diseases-followed-Respiratory Tract Diseases', 'Sepsis-followed-Respiratory Tract Diseases', 'Substance-Related Disorders-make-Pulmonary Disease, Chronic Obstructive', 'Substance-Related Disorders-make-Kidney Diseases', 'Substance-Related Disorders-make-Coronary Artery Disease', 'Death-divide-Coronary Artery Disease', 'Colorectal Neoplasms-prove-Neoplasms', 'Neoplasm Metastasis-prove-Neoplasms', 'Anovulation-refer-Genetic Diseases, Inborn', 'Anovulation-refer-Hirsutism', 'Respiration Disorders-include-Arbovirus Infections', 'Severe Acute Respiratory Syndrome-include-Arbovirus Infections', 'Anovulation-refer-Acne Vulgaris', 'Coronavirus Infections-include-Arbovirus Infections', 'Weight Loss-reserved-Obesity', 'Chiari-Frommel Syndrome-associated-Hypogonadism', 'Hypogonadism-associated-Chiari-Frommel Syndrome', 'Chiari-Frommel Syndrome-associated-Infertility, Female', 'Infertility, Female-associated-Chiari-Frommel Syndrome', 'Chiari-Frommel Syndrome-associated-Osteoporosis', 'Osteoporosis-associated-Chiari-Frommel Syndrome', 'Chiari-Frommel Syndrome-associated-Erectile Dysfunction', 'Erectile Dysfunction-associated-Chiari-Frommel Syndrome', 'Neoplasm Metastasis-induce-Pain', 'Death-lose-Neoplasms', 'Metabolic Syndrome-demonstrate-Dyslipidemias', 'Metabolic Syndrome-demonstrate-Hearing Loss', 'Metabolic Syndrome-evaluate-Hearing Loss', 'Dementia-staff-Death', 'Death-increased-Kidney Diseases', 'Death-precede-Kidney Failure, Chronic', 'Cardiovascular Diseases-vary-Death', 'HIV Infections-become-Infections', 'AIDS Arteritis, Central Nervous System-make-Alzheimer Disease', 'AIDS Arteritis, Central Nervous System-make-Parkinson Disease', 'HIV Infections-associated-Alzheimer Disease', 'Alzheimer Disease-associated-HIV Infections', 'AIDS Arteritis, Central Nervous System-lead-Alzheimer Disease', 'HIV Infections-link-AIDS Arteritis, Central Nervous System', 'HIV Infections-link-Alzheimer Disease', 'Obesity-related-Diabetes Mellitus', 'Osteoporosis-include-Endocrine System Diseases', 'Endocrine System Diseases-include-Hypothyroidism', 'Endocrine System Diseases-occur-Hypothyroidism', 'Endocrine System Diseases-include-Glucose Metabolism Disorders', 'Endocrine System Diseases-occur-Glucose Metabolism Disorders', 'Diabetes Mellitus, Type 2-result-Sotos Syndrome', 'Osteoporosis-occur-Hypothyroidism', 'Diabetes Mellitus, Type 2-occur-Turner Syndrome', 'Osteoporosis-occur-Glucose Metabolism Disorders', 'Sotos Syndrome-occur-Turner Syndrome', 'HIV Infections-obtained-Acquired Immunodeficiency Syndrome', 'Neoplasms-divided-Acquired Immunodeficiency Syndrome', 'Neoplasms-seem-HIV Infections', 'Lupus Erythematosus, Systemic-compare-Kidney Failure, Chronic', 'Erectile Dysfunction-described-Vertebrobasilar Insufficiency', 'Diabetes Mellitus-characterized-Hypotension', 'Metabolic Diseases-characterized-Hypotension', 'Disease-underlie-Metabolism, Inborn Errors', 'Metabolism, Inborn Errors-associated-Lung Diseases', 'Lung Diseases-associated-Metabolism, Inborn Errors', 'Hypoglycemia-compare-Diabetes Mellitus', 'Fanconi Anemia-characterized-Congenital Abnormalities', 'Fanconi Anemia-characterized-Bone Marrow Failure Disorders', 'Fanconi Anemia-characterized-Neoplasms', 'Genetic Diseases, X-Linked-characterized-Congenital Abnormalities', 'Genetic Diseases, X-Linked-characterized-Bone Marrow Failure Disorders', 'Genetic Diseases, X-Linked-characterized-Neoplasms', 'Bone Diseases-composed-Drug-Related Side Effects and Adverse Reactions', 'Polycystic Ovary Syndrome-associated-Metabolic Diseases', 'Metabolic Diseases-associated-Polycystic Ovary Syndrome', 'Polycystic Ovary Syndrome-associated-Dyslipidemias', 'Dyslipidemias-associated-Polycystic Ovary Syndrome', 'Polycystic Ovary Syndrome-develop-Congenital Hyperinsulinism', 'Polycystic Ovary Syndrome-range-Hirsutism', 'Genetic Diseases, Inborn-develop-Congenital Hyperinsulinism', 'Genetic Diseases, Inborn-range-Hirsutism', 'Congenital Hyperinsulinism-range-Hirsutism', 'Back Pain-involve-Fever', 'Back Pain-involve-Asthenia', 'Back Pain-course-Neurologic Manifestations', 'Huntington Disease-include-Sleep Wake Disorders', 'Nervous System Diseases-include-Sleep Wake Disorders', 'Spasms, Infantile-include-Seizures', 'Sleep Wake Disorders-flies-Huntington Disease', 'Sleep Wake Disorders-reflect-Huntington Disease', 'Wounds and Injuries-predominate-Neoplasms', 'Graft vs Host Disease-cause-Death', 'Pulmonary Embolism-avoid-Hemorrhage', 'Neurobehavioral Manifestations-caused-Arbovirus Infections', 'Neurodegenerative Diseases-affect-Death', 'Arbovirus Infections-occur-Alzheimer Disease', 'Arbovirus Infections-occur-Parkinson Disease', 'Arbovirus Infections-occur-Amyotrophic Lateral Sclerosis', 'Arbovirus Infections-occur-Multiple Sclerosis', 'Arbovirus Infections-occur-AIDS Arteritis, Central Nervous System', 'Neurodegenerative Diseases-proposed-Infections', 'Nerve Degeneration-affected-Arbovirus Infections', 'Glioma-associated-Death', 'Death-associated-Glioma', 'Neoplasm Invasiveness-bear-Neoplasms', 'Hepatitis C, Chronic-treat-Fibrosis', 'Hepatitis C, Chronic-reduce-Carcinogenesis', 'Fibrosis-reduce-Carcinogenesis', 'Death-select-Neoplasms', 'Cachexia-select-Neoplasms', 'Leukemia, Lymphocytic, Chronic, B-Cell-develop-Graft vs Host Disease', 'Leukemia, Lymphocytic, Chronic, B-Cell-describe-Graft vs Host Disease', 'Kidney Diseases-manage-Neoplasms', 'Kidney Diseases-progress-Death', 'Neoplasms-progress-Death', 'HIV Infections-divided-Infections', 'HIV Infections-divided-Neoplasms', 'Cardiovascular Diseases-experience-Obesity', 'Hepatitis C-progress-Fibrosis', 'Diabetes, Gestational-recognized-Diabetes Mellitus', 'Death-linked-Amyotrophic Lateral Sclerosis', 'Death-associated-Amyotrophic Lateral Sclerosis', 'Amyotrophic Lateral Sclerosis-associated-Death', 'Angina, Stable-studied-Arrhythmias, Cardiac', 'Hypotension-proceed-Cardiomyopathy, Dilated', 'Hypotension-complicated-Heart Failure', 'Fibrosis-proceed-Cardiomyopathy, Dilated', 'Cardiomyopathy, Dilated-complicated-Heart Failure', 'Cardiomyopathy, Dilated-complicated-Arrhythmias, Cardiac', 'Respiratory Insufficiency-continue-Heart Failure', 'Muscular Dystrophy, Duchenne-continue-Heart Failure', 'Heart Diseases-prevent-Cardiomyopathies', 'Heart Diseases-prevent-Muscular Dystrophy, Duchenne', 'Death-uninfluenced-Diabetes Mellitus', 'Death-uninfluenced-Coronary Artery Disease', 'Dyspnea-suspected-Respiratory Distress Syndrome', 'Dyspnea-suspected-Pulmonary Embolism', 'Bulbar Palsy, Progressive-lead-Malnutrition', 'Bulbar Palsy, Progressive-increase-Respiratory Insufficiency', 'Malnutrition-increase-Respiratory Insufficiency', 'Fatigue-coupled-Muscle Weakness', 'Fatigue-coupled-Respiratory Insufficiency', 'Muscle Weakness-coupled-Respiratory Insufficiency', 'Respiratory Insufficiency-enhance-Liver Neoplasms', 'Death-disable-Stroke', 'Death-prevent-Pulmonary Embolism', 'Mitral Valve Insufficiency-caused-Heart Valve Diseases', 'Pulmonary Heart Disease-underestimated-Death', 'Osteoporotic Fractures-linked-Death', 'Osteoporosis-represent-Fractures, Bone', 'Hip Fractures-linked-Death', 'Anemia, Hemolytic-associated-Myelodysplastic Syndromes', 'Myelodysplastic Syndromes-associated-Anemia, Hemolytic', 'Muscular Dystrophy, Duchenne-characterize-Muscle Weakness', 'Muscular Dystrophy, Duchenne-characterize-Hypertrophy', 'Fibrosis-recommended-Carcinoma, Hepatocellular', 'Carcinoma, Hepatocellular-improve-Desmoplastic Small Round Cell Tumor', 'Genetic Diseases, X-Linked-characterize-Muscle Weakness', 'Genetic Diseases, X-Linked-characterize-Hypertrophy', 'Muscular Dystrophies-characterize-Muscle Weakness', 'Muscular Dystrophies-characterize-Hypertrophy', 'Neoplasms-associated-Hodgkin Disease', 'Hodgkin Disease-associated-Neoplasms', 'Neoplasms-associated-Nephrosis, Lipoid', 'Nephrosis, Lipoid-associated-Neoplasms', 'Kidney Diseases-associated-Hodgkin Disease', 'Hodgkin Disease-associated-Kidney Diseases', 'Hodgkin Disease-associated-Nephrosis, Lipoid', 'Nephrosis, Lipoid-associated-Hodgkin Disease', 'Kidney Diseases-distinguished-Iatrogenic Disease', 'Neoplastic Syndromes, Hereditary-distinguished-Iatrogenic Disease', 'Pulmonary Disease, Chronic Obstructive-suspected-Sleep Apnea Syndromes', 'Cholestasis-indicate-Liver Cirrhosis, Biliary', 'Diabetic Nephropathies-considered-Diabetes Mellitus', 'Apnea-give-Arrhythmias, Cardiac', 'Apnea-give-Bradycardia', 'Homocystinuria-associate-Anophthalmos', 'Anophthalmos-associate-Homocystinuria', 'Glucose Intolerance-indicate-Insulin Resistance', 'Infections-indicate-Insulin Resistance', 'Insulin Resistance-indicate-Diabetes Mellitus', 'Hypoxia-associated-Pancreatic Neoplasms', 'Pancreatic Neoplasms-associated-Hypoxia', 'Scleroderma, Localized-indicated-Neoplasms', 'Muscular Dystrophies-performed-Respiratory Insufficiency', 'Dyspnea-forced-Pulmonary Disease, Chronic Obstructive', 'Urinary Incontinence-managed-Arterial Occlusive Diseases', 'Heart Arrest-represent-Neoplasms', 'Thrombocythemia, Essential-precede-Polycythemia Vera', 'Primary Myelofibrosis-progress-Polycythemia Vera', 'Cardiovascular Diseases-include-Lipodystrophy', 'Cardiovascular Diseases-seen-Lipodystrophy', 'Myocardial Infarction-seen-Lipodystrophy', 'Hepatitis C-lead-Liver Diseases', 'Hepatitis C-lead-Liver Cirrhosis', 'Hepatitis C-lead-Carcinoma, Hepatocellular', 'Hodgkin Disease-develop-Leukemia, Lymphocytic, Chronic, B-Cell', 'Hepatitis C-occur-Acidosis, Lactic', 'Lymphoma-derive-Leukemia', 'Thrombosis-prevent-Pulmonary Embolism', 'Neoplasm Metastasis-treat-Small Cell Lung Carcinoma', 'Neoplasms-result-Nervous System Diseases', 'Death-computed-Intellectual Disability', 'Death-observed-Intellectual Disability', 'Seizures-observed-Death', 'von Hippel-Lindau Disease-complicated-Pheochromocytoma', 'von Hippel-Lindau Disease-complicated-Pelvic Neoplasms', 'von Hippel-Lindau Disease-complicated-Hyperparathyroidism, Primary', 'Seizures-observed-Respiratory Tract Diseases', 'Seizures-observed-Intellectual Disability', 'Respiratory Tract Diseases-observed-Intellectual Disability', 'Infections-associated-Malnutrition', 'Malnutrition-associated-Infections', 'Infections-associated-Gastroenteritis', 'Gastroenteritis-associated-Infections', 'Malnutrition-remain-Infections', 'Aortic Valve Stenosis-treat-Ischemia', 'Aortic Valve Stenosis-treat-Mitral Valve Insufficiency', 'Cystic Fibrosis-lead-Osteoporosis', 'Primary Myelofibrosis-characterized-Fibrosis', 'Fibrosis-characterized-Primary Myelofibrosis', 'Fibrosis-characterized-Myeloproliferative Disorders', 'Myeloproliferative Disorders-characterized-Anemia', 'Death-plummete-HIV Infections', 'Hepatitis C-reviewed-Neoplasms', 'Hepatitis C-reviewed-Lymphoma', 'Cardiovascular Diseases-result-Obesity', 'Diabetes Mellitus-result-Obesity', 'Gallbladder Diseases-result-Obesity', 'Colorectal Neoplasms-prevent-Neoplasms', 'Colorectal Neoplasms-derived-Colorectal Neoplasms, Hereditary Nonpolyposis', 'Laryngitis-involved-Respiratory Insufficiency', 'Acromegaly-suffer-Dyspnea', 'Dyspnea-suffer-Respiratory Insufficiency', 'Pain-carry-Neoplasms', 'Hypercholesterolemia-considered-Atherosclerosis', 'Kidney Failure, Chronic-calculated-Neoplasms', 'Neoplasms-targeted-Kidney Failure, Chronic', 'Disease Progression-characterized-Hyperostosis', 'Disease Progression-characterized-Pain', 'Disease Progression-lead-Pain', 'Disease Progression-characterized-Musculoskeletal Diseases', 'Disease Progression-lead-Musculoskeletal Diseases', 'Hyperostosis-lead-Pain', 'Neoplasms-develop-Pleural Effusion, Malignant', 'Colorectal Neoplasms-seen-Airway Obstruction', 'Death-obtain-Angina Pectoris', 'Infarction-obtain-Angina Pectoris', 'Ketosis-lowered-Coma', 'Sarcoma, Kaposi-associated-Acquired Immunodeficiency Syndrome', 'Acquired Immunodeficiency Syndrome-associated-Sarcoma, Kaposi', 'Thalassemia-contribute-Musculoskeletal Diseases', 'Thalassemia-contribute-Bone Diseases, Metabolic', 'Colitis, Ulcerative-require-Cholangitis', 'Thalassemia-contribute-Fractures, Bone', 'Acquired Immunodeficiency Syndrome-develop-Opportunistic Infections', 'Sarcoma, Kaposi-develop-Opportunistic Infections', 'Hemorrhage-accelerate-Liver Failure', 'Infections-determine-Cystic Fibrosis', 'Hemorrhage-accelerate-Death', 'Liver Failure-accelerate-Death', 'Angina Pectoris-indicated-Constriction, Pathologic', 'Ischemia-indicated-Constriction, Pathologic', 'Stomach Ulcer-contribute-Death', 'Adenomatous Polyposis Coli-estimated-Intestinal Polyposis', 'Adenomatous Polyposis Coli-comprise-Intestinal Polyposis', 'Fractures, Bone-provide-Neoplasms', 'Diabetes Mellitus, Type 2-followed-Death', 'Death-investigated-Aortic Aneurysm, Abdominal', 'Hearing Disorders-range-Deafness', 'Hearing Disorders-range-Drug Hypersensitivity', 'Heart Failure-associated-Psychoses, Substance-Induced', 'Psychoses, Substance-Induced-associated-Heart Failure', 'Heart Failure-precede-Psychoses, Substance-Induced', 'Deafness-range-Drug Hypersensitivity', 'Cerebral Infarction-known-Stroke', 'Cardiovascular Diseases-known-Stroke', 'Neoplasms-hindered-Hypotension', 'Neoplasms-induce-Inflammation', 'Neoplasm Metastasis-constitute-Neoplasms', 'Nervous System Diseases-cause-Urinary Bladder, Neurogenic', 'Urinary Bladder, Neurogenic-cause-Stroke', 'Urinary Bladder, Neurogenic-cause-Spinal Cord Injuries', 'Urinary Bladder, Neurogenic-cause-Amyotrophic Lateral Sclerosis', 'Venous Thromboembolism-occur-Neoplasms', 'Headache-account-Lung Neoplasms', 'Headache-account-Alcoholism', 'Pain-limit-Chronic Disease', 'Pain-reduce-Edema', 'Stroke-enhance-Inflammation', 'Communicable Diseases-precipitate-Fever', 'Communicable Diseases-result-Dystonia', 'Coronary Artery Disease-occur-Necrosis', 'Respiratory Tract Diseases-cause-Hypoxia', 'Drug-Related Side Effects and Adverse Reactions-induce-Heart Arrest', 'Respiratory Tract Diseases-used-Pulmonary Disease, Chronic Obstructive', 'Hypoxia-used-Pulmonary Disease, Chronic Obstructive', 'Stroke-occur-Hypertension', 'Death-lead-Drug Overdose', 'HIV Infections-experience-AIDS Arteritis, Central Nervous System', 'Thalassemia-suspected-Anemia', 'Thalassemia-include-Anemia, Hemolytic', 'Hemophilia A-suffer-Cardiovascular Diseases', 'Kidney Diseases, Cystic-include-Neoplasms', 'Abnormalities, Drug-Induced-remove-Kidney Diseases', 'Brachial Plexus Neuropathies-induced-Parkinson Disease', 'Nervous System Diseases-range-Hypotension', 'Sleep Wake Disorders-include-Sleepiness', 'Sleep Wake Disorders-function-Sleepiness', 'Sleep Wake Disorders-function-Death', 'Dementia-experience-Musculoskeletal Pain', 'Aortic Aneurysm-identified-Death', 'Aortic Aneurysm-identified-Rupture', 'Rupture-identified-Aortic Aneurysm', 'Rupture-associated-Aortic Aneurysm', 'Aortic Aneurysm-associated-Rupture', 'Drug-Related Side Effects and Adverse Reactions-limited-Pain', 'Diabetes Mellitus-face-Cardiovascular Diseases', 'Muscular Atrophy, Spinal-present-Fatigue', 'Neoplasm Metastasis-require-Pain', 'Hepatitis-increase-Death, Sudden, Cardiac', 'Sleep Wake Disorders-increase-Death, Sudden, Cardiac', 'Neoplasm Metastasis-short-Neoplasms', 'Neoplasms-cause-Fractures, Bone', 'Neoplasms-cause-Hypercalcemia', 'Pain-short-Neoplasms', 'Fractures, Bone-short-Neoplasms', 'Hypercalcemia-short-Neoplasms', 'Critical Illness-select-Neoplasms', 'Death-expect-Cardiovascular Diseases', 'Death-expect-Infections', 'Death-expect-Sepsis', 'Neoplasms-yield-Leukemia, Myeloid, Acute', 'Colorectal Neoplasms-arise-Cystic Fibrosis', 'Esophageal Squamous Cell Carcinoma-improve-Death', 'Rare Diseases-lead-Blood Coagulation Disorders', 'Rare Diseases-lead-Spherocytosis, Hereditary', 'Esophageal Squamous Cell Carcinoma-enrolled-Neoplasms', 'Cardiomyopathies-related-Muscular Dystrophy, Duchenne', 'Fibrosis-lead-Heart Failure', 'Muscular Dystrophy, Duchenne-represent-Heart Diseases', 'Thrombosis-include-Hemorrhage', 'Heart Diseases-represent-Death', 'Venous Thrombosis-include-Hemorrhage', 'Leukocytosis-include-Hemorrhage', 'Leukocytosis-include-Thrombosis', 'Familial Primary Pulmonary Hypertension-demonstrate-Pleural Effusion', 'Amyotrophic Lateral Sclerosis-compare-Inflammation', 'Amyotrophic Lateral Sclerosis-altered-Inflammation', 'Neoplasms-assigned-Death', 'Death-characterized-Cardiovascular Diseases', 'Death-characterized-Neoplasms', 'Lymphopenia-ameliorate-Neurodegenerative Diseases', 'Communicable Diseases-facilitate-Heart Failure', 'Inflammation-thought-Substance-Related Disorders', 'Death-contribute-Chronic Disease', 'Breast Neoplasms-contribute-Chronic Disease', 'Breast Neoplasms-take-Neoplasms', 'Bacterial Infections-lead-Drug Hypersensitivity', 'Inflammation-lead-Drug Hypersensitivity', 'Pain-lead-Drug Hypersensitivity', 'Pain-present-Pancreatitis', 'Immunologic Deficiency Syndromes-weaken-Infections', 'Immunologic Deficiency Syndromes-weaken-Neoplasms', 'Endometriosis-associated-Inflammation', 'Inflammation-associated-Endometriosis', 'Endometriosis-render-Inflammation', 'Endometriosis-characterized-Inflammation', 'Sexual Dysfunction, Physiological-diagnosed-Immunologic Deficiency Syndromes', 'HIV Infections-result-Death', 'Death, Sudden-fall-Dyspnea', 'Neoplasms-play-Prostatic Neoplasms', 'Neoplasms-become-Prostatic Neoplasms', 'Carcinoma, Hepatocellular-detected-Cholangiocarcinoma', 'Carcinoma, Hepatocellular-decreased-Cholangiocarcinoma', 'Myelodysplastic Syndromes-associated-Invasive Fungal Infections', 'Invasive Fungal Infections-associated-Myelodysplastic Syndromes', 'Myelodysplastic Syndromes-associated-Hematologic Neoplasms', 'Hematologic Neoplasms-associated-Myelodysplastic Syndromes', 'Invasive Fungal Infections-associated-Hematologic Neoplasms', 'Hematologic Neoplasms-associated-Invasive Fungal Infections', 'Coronary Artery Disease-result-Atherosclerosis', 'Coronary Artery Disease-involve-Inflammation', 'Leukemia, Myeloid-drive-Neoplasms', 'Chromosome Aberrations-found-Myelodysplastic Syndromes', 'Bone Marrow Failure Disorders-mimic-Myelodysplastic Syndromes', 'Thromboembolism-develop-Dysgeusia', 'Cystic Fibrosis-increase-Central Nervous System Diseases', 'Cystic Fibrosis-prevent-Lung Diseases', 'Death-apply-Obesity', 'Osteoporosis-missed-Fractures, Bone', 'Paralysis-model-Epilepsy', 'Death-checked-Breast Neoplasms', 'Skin Diseases-assessed-Diabetes Mellitus', 'Skin Diseases-assessed-Kidney Diseases', 'Infections-require-Pneumonia', 'Pneumonia-require-Erectile Dysfunction', 'Pneumonia-require-Urinary Incontinence', 'Crohn Disease-predisposed-Psoriasis', 'Crohn Disease-predisposed-Arthritis', 'Crohn Disease-suffer-Infections', 'Psoriasis-suffer-Infections', 'Arthritis-suffer-Infections', 'Muscular Atrophy, Spinal-used-Neoplasms', 'Parkinson Disease-determine-Weight Loss', 'Adrenal Insufficiency-promote-Myelodysplastic Syndromes', 'Immunologic Deficiency Syndromes-occur-Myelodysplastic Syndromes', 'Psoriasis-associated-Coronary Artery Disease', 'Coronary Artery Disease-associated-Psoriasis', 'Psoriasis-associated-Stroke', 'Stroke-associated-Psoriasis', 'Psoriasis-treat-Cardiovascular Diseases', 'Spinal Cord Injuries-result-Spinal Cord Diseases', 'Spinal Cord Injuries-result-Myelitis', 'Spinal Cord Injuries-result-Aneurysm', 'Spinal Cord Injuries-result-Arteriovenous Malformations', 'Spinal Cord Injuries-result-Multiple Sclerosis', 'Wounds and Injuries-caused-Spinal Cord Diseases', 'Wounds and Injuries-caused-Myelitis', 'Shock-exhibit-Urinary Bladder Diseases', 'Wounds and Injuries-result-Aneurysm', 'Wounds and Injuries-result-Arteriovenous Malformations', 'Urinary Bladder Diseases-exhibit-Ataxia', 'Wounds and Injuries-result-Multiple Sclerosis', 'Ataxia-develop-Urolithiasis', 'Ataxia-result-Infections', 'Ataxia-develop-Hydronephrosis', 'Ataxia-result-Renal Insufficiency', 'Weight Loss-undertaken-Migraine Disorders', 'Weight Loss-related-Headache', 'Weight Loss-undertaken-Obesity', 'Weight Loss-done-Migraine Disorders', 'Critical Illness-provide-Neoplasms', 'Kidney Diseases-increase-Neoplasms', 'Migraine Disorders-undertaken-Obesity', 'Cardiac Output, Low-correlate-Neoplasms', 'Inflammation-result-Death', 'Hemorrhage-predispose-Death', 'Hemoglobinopathies-characterized-Anemia, Hemolytic', 'Hypertension-aid-Kidney Diseases', 'Neoplasm Metastasis-arise-Gastrointestinal Stromal Tumors', 'Pain-consist-Renal Insufficiency', 'Kidney Diseases-include-Fabry Disease', 'Neoplasms-suffer-Dyspnea', 'Neoplasms-transferred-Pain', 'Dyspnea-transferred-Pain', 'Cerebral Hemorrhage-elongate-Neoplasms', 'Atherosclerosis-found-Arthritis, Rheumatoid', 'Arthritis, Rheumatoid-associated-Inflammation', 'Inflammation-associated-Arthritis, Rheumatoid', 'Sarcoma, Kaposi-become-Neoplasms', 'Sarcoma, Kaposi-result-Inflammation', 'Sarcoma, Kaposi-induced-Inflammation', 'Sarcoma, Kaposi-comprised-Neoplasms', 'Inflammation-comprised-Neoplasms', 'Death-contributed-Chronic Disease', 'Genetic Diseases, Inborn-associated-Epilepsy', 'Epilepsy-associated-Genetic Diseases, Inborn', 'Neoplasms-found-Vaginal Neoplasms', 'Hodgkin Disease-found-Vaginal Neoplasms', 'Colorectal Neoplasms-found-Vaginal Neoplasms', 'Head and Neck Neoplasms-found-Vaginal Neoplasms', 'Obesity-increasing-Diabetes Mellitus, Type 2', 'Diabetes Mellitus, Type 2-noted-Glucose Intolerance', 'Hemorrhage-require-Endocarditis', 'Cerebrospinal Fluid Leak-managed-Death', 'Death-implicate-Malaria', 'Death-implicate-Anemia', 'Hypertension-excluded-Stroke', 'Hypertrophy, Left Ventricular-excluded-Stroke', 'Porphyrias, Hepatic-comprise-Genetic Diseases, Inborn', 'Carcinoma, Hepatocellular-present-End Stage Liver Disease', 'Disease Progression-continue-Chemical and Drug Induced Liver Injury', 'Death-disappear-Chemical and Drug Induced Liver Injury', 'Neoplasms-eliminated-Heart Diseases', 'Death-eliminated-Heart Diseases', 'Infections-lead-Carcinoma, Hepatocellular', 'Death-associated-Cardiovascular Abnormalities', 'Cardiovascular Abnormalities-associated-Death', 'Death-associated-Hydrocephalus', 'Hydrocephalus-associated-Death', 'Death-combine-Hydrocephalus', 'Death-associated-Cerebellar Diseases', 'Cerebellar Diseases-associated-Death', 'Death-combine-Cerebellar Diseases', 'Cardiovascular Abnormalities-combine-Hydrocephalus', 'Cardiovascular Abnormalities-combine-Cerebellar Diseases', 'Hydrocephalus-combine-Cerebellar Diseases', 'Ischemia-produce-Angina Pectoris', 'Carcinoma, Hepatocellular-used-Neoplasms', 'Neoplasms-lose-Diabetes Mellitus', 'Death-lose-Diabetes Mellitus', 'Primary Myelofibrosis-contrast-Essential Tremor', 'Heart Arrest-include-Heart Diseases', 'Cyanosis-persist-Arrhythmias, Cardiac', 'Cyanosis-persist-Thromboembolism', 'Arrhythmias, Cardiac-persist-Thromboembolism', 'Death-shown-Lung Diseases', 'Death-shown-Aneurysm', 'HIV Infections-provide-Death', 'Acquired Immunodeficiency Syndrome-provide-Death', 'Retinoblastoma-develop-Neoplasms', 'Campomelic Dysplasia-result-Abnormalities, Drug-Induced', 'Genetic Diseases, Inborn-result-Abnormalities, Drug-Induced', 'Retinoblastoma-face-Head and Neck Neoplasms', 'Epilepsy, Benign Neonatal-reduce-Death', 'Campomelic Dysplasia-observed-Congenital, Hereditary, and Neonatal Diseases and Abnormalities', 'Drug-Related Side Effects and Adverse Reactions-characterized-Peripheral Nervous System Diseases', 'Death-become-Communicable Diseases', 'Drug-Related Side Effects and Adverse Reactions-characterized-Myalgia', 'Drug-Related Side Effects and Adverse Reactions-characterized-Neutropenia', 'Sepsis-become-Death', 'Sepsis-move-Alzheimer Disease', 'Death-move-Alzheimer Disease', 'Death-associated-Arteriosclerosis', 'Arteriosclerosis-associated-Death', 'Death-associated-Cerebrospinal Fluid Otorrhea', 'Cerebrospinal Fluid Otorrhea-associated-Death', 'Arteriosclerosis-infect-Infections', 'Neoplasm Metastasis-result-Neurologic Manifestations', 'Prostatic Hyperplasia-detected-Neoplasms', 'Hypertension-exceed-Cardiomyopathy, Hypertrophic', 'Cardiomyopathy, Hypertrophic-double-Hypertension', 'Cardiomyopathy, Hypertrophic-carry-Death', 'Hypertension-identify-Cardiomyopathies', 'Cardiomyopathy, Hypertrophic-double-Heart Diseases', 'Fibrosis-associated-Communicable Diseases', 'Communicable Diseases-associated-Fibrosis', 'Neoplasm Metastasis-reduce-Drug-Related Side Effects and Adverse Reactions', 'Death-analysed-Spinal Cord Injuries', 'Diabetes Mellitus, Type 1-associated-Hypertension', 'Hypertension-associated-Diabetes Mellitus, Type 1', 'Hypertension-associated-Diabetic Nephropathies', 'Diabetic Nephropathies-associated-Hypertension', 'Diabetes Mellitus-remain-Hypertension', 'Atherosclerosis-portend-Death', 'Antiphospholipid Syndrome-necessitate-Thrombosis', 'Cerebrovascular Disorders-predict-Death', 'Bradycardia-reduce-Death', 'Neoplasm Metastasis-use-Neoplasms', 'Sarcopenia-defined-Pain', 'Pain-decrease-Sarcopenia', 'Nerve Degeneration-prove-Infections', 'Myoclonic Epilepsies, Progressive-compare-Obesity', 'Fibrosarcoma-compare-Neoplasms', 'Disease Progression-associated-Heart Failure', 'Heart Failure-associated-Disease Progression', 'Arthritis-require-Renal Insufficiency', 'Arthritis-report-Liver Diseases', 'Diabetes Mellitus-report-Liver Diseases', 'Heart Failure-report-Liver Diseases', 'Neoplasms-report-Liver Diseases', 'Liver Diseases-prevent-Diabetes Mellitus', 'Liver Diseases-prevent-Obesity', 'Liver Failure, Acute-detect-Epilepsy', 'Obesity, Maternal-elevate-Non-alcoholic Fatty Liver Disease', 'Cachexia-related-Neoplasms', 'Cachexia-play-Inflammation', 'Alagille Syndrome-calculate-Cerebral Infarction', 'Non-alcoholic Fatty Liver Disease-linked-Chronic Disease', 'HIV Infections-describe-Infections', 'Inflammation-describe-Infections', 'Neoplasms-associated-Fibrosis', 'Fibrosis-associated-Neoplasms', 'Liver Failure-included-Carcinoma, Hepatocellular', 'Glioma-undergo-Neoplasms', 'Scleroderma, Systemic-characterized-Fibrosis', 'Hypothermia-used-Death', 'Hypothermia-mitigate-Death', 'Hypothermia-used-Brain Injuries', 'Hypothermia-minimize-Brain Injuries', 'Death-used-Prostatic Neoplasms', 'Muscular Dystrophies-mitigate-Drug-Related Side Effects and Adverse Reactions', 'Infections-remain-Lupus Erythematosus, Systemic', 'Multiple Organ Failure-include-Infections', 'Lupus Erythematosus, Systemic-exhibit-Infections', 'Hyperthyroidism-cure-Hypertension', 'Endocrine System Diseases-explain-Hypertension', 'Hypertension-explain-Thyroid Diseases', 'Takotsubo Cardiomyopathy-associated-Heart Failure', 'Heart Failure-associated-Takotsubo Cardiomyopathy', 'Death-collected-Takotsubo Cardiomyopathy', 'Heart Failure-collected-Takotsubo Cardiomyopathy', 'Atherosclerosis-assessed-Scleroderma, Systemic', 'Atherosclerosis-assessed-Arthritis, Rheumatoid', 'Scleroderma, Systemic-compared-Arthritis, Rheumatoid', 'Scleroderma, Systemic-recruited-Arthritis, Rheumatoid', 'Language Disorders-decline-Psychoses, Substance-Induced', 'Glaucoma, Open-Angle-related-Amyotrophic Lateral Sclerosis', 'Drug-Related Side Effects and Adverse Reactions-involved-Neoplasms', 'Drug-Related Side Effects and Adverse Reactions-involved-Neurodegenerative Diseases', 'Drug-Related Side Effects and Adverse Reactions-involved-Diabetes Mellitus', 'Drug-Related Side Effects and Adverse Reactions-involved-Cardiovascular Diseases', 'Drug-Related Side Effects and Adverse Reactions-involved-Autoimmune Diseases', 'Learning Disabilities-employed-Mitochondrial Diseases', 'Learning Disabilities-generate-Mitochondrial Diseases', 'Death-consist-Heart Diseases', 'Weight Loss-lead-Obesity', 'Chronic Disease-exacerbated-Communicable Diseases', 'Diabetes Mellitus-tend-Death', 'Diabetes Mellitus-tend-Cardiovascular Diseases', 'Death-include-Lung Injury', 'Death-include-Peripheral Arterial Disease', 'Opportunistic Infections-contribute-Infections', 'Opportunistic Infections-contribute-Acquired Immunodeficiency Syndrome', 'Weight Loss-followed-Fever', 'Diabetes Mellitus-identify-Diabetic Nephropathies', 'Vasculitis, Central Nervous System-present-Vasculitis', 'Neoplasms-project-Heart Septal Defects, Atrial', 'Neoplasms-project-Ductus Arteriosus, Patent', 'Amyotrophic Lateral Sclerosis-develop-Mitochondrial Diseases', 'HIV Infections-used-Acquired Immunodeficiency Syndrome', 'HIV Infections-measure-Acquired Immunodeficiency Syndrome', 'Death-used-HIV Infections', 'Death-measure-HIV Infections', 'Death-used-Acquired Immunodeficiency Syndrome', 'Death-measure-Acquired Immunodeficiency Syndrome', 'Olfaction Disorders-observed-Alzheimer Disease', 'Hypertension, Pulmonary-associated-Death, Sudden', 'Death, Sudden-associated-Hypertension, Pulmonary', 'Brain Ischemia-correlate-Death', 'Death-become-Aortic Arch Syndromes', 'Brain Ischemia-remain-Aneurysm', 'Aneurysm-correlate-Death', 'Cardiovascular Diseases-involved-Coronary Artery Disease', 'Diabetes Mellitus-lead-Diabetes Mellitus, Type 2', 'Inflammation-examined-Viremia', 'Inflammation-examined-Coinfection', 'Chronic Disease-explained-Diabetes Mellitus', 'Diabetes Mellitus-measure-Hypotension', 'Obesity-live-Cardiovascular Diseases', 'HIV Infections-shift-Death', 'Nervous System Diseases-uncover-Microvascular Angina', 'Pain-alleviate-Death', 'Hypotension-dominated-Polycythemia', 'Infections-lead-Colitis', 'Infections-lead-Anemia', 'Venous Thromboembolism-added-Chronic Disease', 'Churg-Strauss Syndrome-include-Vasculitis', 'Granulomatosis with Polyangiitis-include-Vasculitis', 'Granulomatosis with Polyangiitis-known-Churg-Strauss Syndrome', 'Vasculitis-present-Pulmonary Heart Disease', 'Neurodegenerative Diseases-preceded-Abnormalities, Drug-Induced', 'Breast Neoplasms-calculated-Death', 'Edema-reveal-Vasculitis', 'Fibrosis-reveal-Vasculitis', 'Neoplasms-assessed-Tibial Meniscus Injuries', 'Death-compared-Diabetes Mellitus, Type 2', 'Lymphoma-limit-Drug-Related Side Effects and Adverse Reactions', 'Wounds and Injuries-mediated-Headache Disorders, Secondary', 'Diabetes Mellitus, Type 2-admitted-Hypoglycemia', 'Neutropenia-use-Drug-Related Side Effects and Adverse Reactions', 'Gastroesophageal Reflux-visit-Digestive System Neoplasms', 'Diabetes Mellitus-lost-Chronic Disease', 'Death-detected-Shock, Septic', 'Obesity-display-Dyslipidemias', 'Neoplasm Metastasis-associated-Neurodegenerative Diseases', 'Neurodegenerative Diseases-associated-Neoplasm Metastasis', 'Spinal Cord Neoplasms-associated-Neurodegenerative Diseases', 'Neurodegenerative Diseases-associated-Spinal Cord Neoplasms', 'Muscular Diseases-combine-Muscle Weakness', 'Muscular Diseases-combine-Contracture', 'Lung Injury-render-Infections', 'Adenocarcinoma-originate-Carcinogenesis', 'Adenocarcinoma of Lung-originate-Infections', 'Inflammation-predispose-Infections', 'Inflammation-predispose-Neoplasms', 'Cockayne Syndrome-characterized-Stomatognathic Diseases', 'Breast Neoplasms-provide-Death', 'Arthritis, Rheumatoid-appear-Atherosclerosis', 'Non-alcoholic Fatty Liver Disease-base-Coronary Artery Disease', 'Infant, Newborn, Diseases-achieve-HIV Infections', 'Anemia-found-Renal Insufficiency, Chronic', 'Muscular Dystrophy, Duchenne-characterised-Muscle Weakness', 'Genetic Diseases, X-Linked-characterised-Muscle Weakness', 'Adenocarcinoma-compare-Neoplasms', 'Carcinoma, Ductal-associated-Adenocarcinoma', 'Adenocarcinoma-associated-Carcinoma, Ductal', 'Adenocarcinoma-associated-Breast Neoplasms', 'Breast Neoplasms-associated-Adenocarcinoma', 'Death-missed-Neoplasms', 'Prostatic Neoplasms-undergo-Hypogonadism', 'Hypogonadism-undergo-Prostatic Neoplasms', 'Alzheimer Disease-thought-Inflammation', 'Periodontitis-affect-Infections', 'Periodontitis-exhibit-Infections', 'Infections-affect-Alzheimer Disease', 'Chagas Cardiomyopathy-lead-Heart Failure', 'Mitochondrial Diseases-involved-Liver Neoplasms', 'Mitochondrial Diseases-linked-Liver Neoplasms', 'Diabetes Mellitus-prevented-Obesity', 'Heart Diseases-consist-Coronary Artery Disease', 'Heart Diseases-consist-Heart Valve Diseases', 'Heart Diseases-consist-Cardiomyopathy, Dilated', 'Heart Diseases-consist-Hypertension', 'Heart Failure-caused-Hypertension', 'Heart Failure-caused-Cardiomyopathy, Dilated', 'Death, Sudden-follow-Cardiomyopathy, Dilated', 'Heart Failure-follow-Coronary Artery Disease', 'Death-caused-Cardiomyopathy, Dilated', 'Heart Failure-follow-Cardiomyopathy, Dilated', 'Coronary Artery Disease-follow-Cardiomyopathy, Dilated', 'Arthritis, Rheumatoid-achieve-Pain', 'Arthritis, Rheumatoid-prevent-Joint Diseases', 'Pain-prevent-Joint Diseases', 'Arthritis, Rheumatoid-lead-Death', 'Autoimmune Diseases-cause-Pain', 'Autoimmune Diseases-lead-Death', 'Cataract-necessitate-Diabetes Mellitus', 'Cataract-diagnosed-Osteomyelitis', 'Werner Syndrome-diagnosed-Neoplasms', 'Myoclonus-account-Diabetes Mellitus', 'Oculocerebrorenal Syndrome-exclude-Venous Thrombosis', 'Hypopituitarism-result-Acromegaly', 'Hypereosinophilic Syndrome-characterized-Eosinophilia', 'Hypereosinophilic Syndrome-characterized-Multiple Organ Failure', 'Unconsciousness-deliver-Shock', 'Unconsciousness-treat-Arrhythmias, Cardiac', 'Shock-treat-Arrhythmias, Cardiac', 'Eosinophilia-characterized-Lymphoma, T-Cell', 'Multiple Organ Failure-precede-Lymphoma, T-Cell', 'Metabolic Diseases-experience-Death', 'Metabolic Diseases-experience-Colorectal Neoplasms', 'Uremia-increase-Death', 'Uremia-increase-Renal Insufficiency', 'Diabetic Nephropathies-increase-Death', 'Diabetic Nephropathies-increase-Renal Insufficiency', 'Heart Diseases-account-Pneumonia', 'Enteritis-cause-Death', 'Heart Diseases-account-HIV Infections', 'Death-reflect-Respiratory Tract Diseases', 'Death-reflect-Cardiovascular Diseases', 'Death-reflect-Neoplasms', 'Death-reflect-Death, Sudden', 'Death-reflect-Arrhythmias, Cardiac', 'Infections-included-Sepsis', 'Cystic Fibrosis-achieved-Death', 'Sepsis-identify-Infections', 'Lung Diseases, Obstructive-result-Cystic Fibrosis', 'Malnutrition-result-Cystic Fibrosis', 'Death-listed-Heart Diseases', 'Heart Diseases-listed-Diabetes Mellitus', 'Neoplasms-develop-Hypopituitarism', 'Drug-Related Side Effects and Adverse Reactions-occur-Intracranial Hemorrhages', 'Drug-Related Side Effects and Adverse Reactions-occur-Lupus Erythematosus, Systemic', 'Hypopituitarism-develop-Wounds and Injuries', 'Drug-Related Side Effects and Adverse Reactions-occur-Arthritis, Rheumatoid', 'Gastrointestinal Diseases-lead-Bacterial Infections', 'Drug-Related Side Effects and Adverse Reactions-occur-Multiple Sclerosis', 'Drug-Related Side Effects and Adverse Reactions-contain-Neurotoxicity Syndromes', 'Drug-Related Side Effects and Adverse Reactions-contain-Respiratory Insufficiency', 'Drug-Related Side Effects and Adverse Reactions-occur-Myasthenia Gravis', 'Drug-Related Side Effects and Adverse Reactions-contain-Lung Diseases', 'Intracranial Hemorrhages-contain-Neurotoxicity Syndromes', 'Intracranial Hemorrhages-contain-Respiratory Insufficiency', 'Lupus Erythematosus, Systemic-contain-Neurotoxicity Syndromes', 'Arthritis, Rheumatoid-contain-Neurotoxicity Syndromes', 'Vasculitis-contain-Neurotoxicity Syndromes', 'Vasculitis-contain-Respiratory Insufficiency', 'Multiple Sclerosis-contain-Neurotoxicity Syndromes', 'Neurotoxicity Syndromes-contain-Respiratory Insufficiency', 'Neurotoxicity Syndromes-contain-Myasthenia Gravis', 'Neurotoxicity Syndromes-contain-Lung Diseases', 'Neurotoxicity Syndromes-contain-Fibrosis', 'Death-related-Gallstones', 'Liver Diseases, Alcoholic-develop-Anemia, Hemolytic', 'Cardiotoxicity-demonstrate-Cardiomyopathies', 'Ischemia-cause-Hypertension', 'Death-prevent-Stomach Neoplasms', 'Budd-Chiari Syndrome-expected-Pain', 'Jaundice, Obstructive-develop-Airway Obstruction', 'Abnormalities, Drug-Induced-include-Neoplasms', 'Thrombophlebitis-operated-Thrombosis', 'Neoplasms-underlie-Blood Coagulation Disorders', 'Thrombophlebitis-cause-Pain', 'Mediastinal Cyst-include-Pericardial Effusion', 'Death-experience-Kidney Diseases', 'Diabetes Mellitus, Type 1-evaluate-Coinfection', 'Death-associate-Liver Cirrhosis', 'Liver Cirrhosis-associate-Death', 'Neoplasms-confined-Carcinoma, Hepatocellular', 'Death-caused-Hemostatic Disorders', 'Infections-lead-Opisthorchiasis', 'Heart Septal Defects, Atrial-reduce-Death', 'Uterine Cervical Neoplasms-derive-Neoplasms', 'Dementia-taken-Hyperlipidemias', 'Dementia-prevent-Cardiovascular Diseases', 'Hyperlipidemias-prevent-Cardiovascular Diseases', 'Liver Failure-promote-Inflammation', 'HIV Infections-put-Hypertension', 'Hypertrophy-complicate-Chronic Disease', 'Sinusitis-complicate-Chronic Disease', 'Cardiomyopathy, Hypertrophic-develop-Fatty Liver', 'Death-calculated-Hypertension', 'Diabetes Mellitus-interact-Death', 'Stroke-increase-Adenomatous Polyposis Coli', 'Anemia, Sickle Cell-lead-Anemia, Hemolytic', 'Aneurysm-show-Hemoperitoneum', 'Cardiac Output, Low-show-Hemoperitoneum', 'Coronary Artery Disease-decline-Death', 'Stroke-decline-Death', 'Pulmonary Disease, Chronic Obstructive-decline-Death', 'Pain-enrolled-Anemia, Sickle Cell', 'Death-contribute-Anemia', 'Ovarian Neoplasms-treat-Infertility, Female', 'Cerebral Hemorrhage-assess-Carcinogenesis', 'Cerebral Hemorrhage-demonstrated-Carcinogenesis', 'Obesity-bring-Osteoarthritis', 'Hypoglycemia-monitor-Hypotension', 'Insulin Resistance-monitor-Hypotension', 'Diabetes Mellitus-monitor-Hypotension', 'Death-include-Hyperglycemia', 'Communicable Diseases-cause-Infections', 'Idiopathic Pulmonary Fibrosis-culminate-Respiratory Insufficiency', 'Idiopathic Pulmonary Fibrosis-impair-Fibrosis', 'Breast Neoplasms-avoid-Wounds and Injuries', 'Breast Neoplasms-protect-Lymphedema', 'Leukemia-feed-Neoplasms', 'Neoplasms-comprise-Lung Neoplasms', 'Neoplasm Metastasis-survive-Death', 'Fistula-result-Carotid Artery Diseases', 'Fabry Disease-characterized-Renal Insufficiency', 'Fabry Disease-characterized-Stroke', 'Fabry Disease-characterized-Cardiomyopathy, Hypertrophic', 'Hepatic Insufficiency-increase-Long QT Syndrome', 'Anemia, Sickle Cell-characterized-Vascular System Injuries', 'Cholestasis-imply-Spinocerebellar Ataxias', 'Extranodal Extension-predict-Neoplasms', 'Liver Failure-present-Glycogen Storage Disease Type III', 'Stomach Neoplasms-associated-Neoplasm Metastasis', 'Neoplasm Metastasis-associated-Stomach Neoplasms', 'Diarrhea-occur-Death', 'Urethral Neoplasms-occur-Death', 'Acute Kidney Injury-occur-Death', 'Retinal Diseases-occur-Death', 'Vomiting-occur-Death', 'Mastocytosis, Systemic-include-Mastocytosis', 'Leukemia, Mast-Cell-include-Mastocytosis', 'Mastocytosis-divide-Neoplasms', 'Pain Insensitivity, Congenital-associated-HIV Infections', 'HIV Infections-associated-Pain Insensitivity, Congenital', 'Peripheral Nervous System Diseases-screen-AIDS-Associated Nephropathy', 'Metabolic Syndrome-established-Diabetes Mellitus', 'Retinal Diseases-include-Anophthalmos', 'Death-assigned-Malocclusion', 'Drug Hypersensitivity-include-Anophthalmos', 'Conjunctivitis-include-Anophthalmos', 'Sleep Wake Disorders-correlated-Pain', "Sleep Wake Disorders-documented-Sjogren's Syndrome", 'Sleep Wake Disorders-suggested-Sleep Apnea Syndromes', "Sjogren's Syndrome-suggested-Sleep Apnea Syndromes", "Sjogren's Syndrome-include-Arthritis", "Sjogren's Syndrome-include-Rheumatic Diseases", "Sjogren's Syndrome-cause-Pain", "Sjogren's Syndrome-include-Fatigue", "Sjogren's Syndrome-contribute-Sleep Wake Disorders", 'Arthritis-contribute-Sleep Wake Disorders', 'Rheumatic Diseases-cause-Pain', 'Rheumatic Diseases-contribute-Sleep Wake Disorders', 'Fatigue-contribute-Sleep Wake Disorders', 'Death-reduce-Nervous System Diseases', 'Seizures-include-Glioblastoma', 'Neoplasms-identified-Breast Neoplasms', 'Seizures-include-Sleep Apnea Syndromes', 'Sleep Apnea Syndromes-associated-Arrhythmias, Cardiac', 'Arrhythmias, Cardiac-associated-Sleep Apnea Syndromes', 'Scoliosis-include-Sleep Apnea Syndromes', 'Contracture-include-Sleep Apnea Syndromes', 'Dementia-experience-Stroke', 'Cardiovascular Diseases-include-Drug-Related Side Effects and Adverse Reactions', 'Cardiovascular Diseases-include-Wounds and Injuries', 'Cardiovascular Diseases-induce-Inflammation', 'Drug-Related Side Effects and Adverse Reactions-induce-Inflammation', 'Wounds and Injuries-induce-Inflammation', 'Death-result-Carcinoma, Hepatocellular', 'Fibrosis-result-Carcinoma, Hepatocellular', 'Polyneuropathies-detected-Muscular Diseases', 'Aneurysm-limited-Death', 'Death-used-Aneurysm', 'Death-consider-Aneurysm', 'Shock-recognized-Death', 'Heart Diseases-remain-Nervous System Diseases', 'Wounds and Injuries-produce-Neurobehavioral Manifestations', 'Mitral Valve Insufficiency-include-Tricuspid Valve Insufficiency', 'Neoplasms-restrain-Lung Neoplasms', 'Fistula-avoid-Ischemia', 'Fistula-mature-Heart Failure', 'Myelodysplastic Syndromes-vary-Inflammation', 'Death-decrease-Heredodegenerative Disorders, Nervous System', 'Emphysema-accompany-Idiopathic Pulmonary Fibrosis', 'Gastrointestinal Diseases-range-Drug Hypersensitivity', 'Gastrointestinal Diseases-range-Infections', 'Anemia-summarize-Neoplasms', 'Renal Insufficiency, Chronic-summarize-Neoplasms', 'Diabetes Mellitus, Type 2-preceded-Obesity', 'Lymphedema-affect-Turner Syndrome', 'Diabetes Mellitus, Type 2-preceded-Albuminuria', 'Turner Syndrome-manage-Lymphedema', 'Neurodegenerative Diseases-display-Tauopathies', 'Neurodegenerative Diseases-display-Movement Disorders', 'Tauopathies-display-Movement Disorders', 'Kidney Failure, Chronic-refer-Abdominal Pain', 'Genetic Diseases, Inborn-result-Hepatolenticular Degeneration', 'Kidney Failure, Chronic-refer-Headache Disorders, Secondary', 'Genetic Diseases, Inborn-result-Menkes Kinky Hair Syndrome', 'Chemical and Drug Induced Liver Injury-show-Metabolic Diseases', 'Hepatolenticular Degeneration-lead-Liver Cirrhosis', 'Hepatolenticular Degeneration-lead-Nervous System Diseases', 'Arteriovenous Fistula-place-Heart Failure', 'Arteriovenous Fistula-place-Peripheral Arterial Disease', 'Fractures, Bone-merit-Osteoporosis', 'Genetic Diseases, Inborn-cause-Blindness', 'Genetic Diseases, Inborn-cause-Hearing Loss, Central', 'Genetic Diseases, Inborn-cause-Cardiomyopathies', 'Genetic Diseases, Inborn-cause-Endocrine System Diseases', 'Genetic Diseases, Inborn-cause-Metabolic Diseases', 'Arthritis, Rheumatoid-estimate-Neoplasms', 'Urinary Bladder Diseases-proceed-Urinary Incontinence', 'Aortic Valve Insufficiency-related-Death', 'Death-decrease-Liver Diseases', 'Cerebrovascular Disorders-reduce-Death', 'Blindness-reach-Vision Disorders', 'End Stage Liver Disease-compare-Purpura, Thrombocytopenic', 'Glioma-use-Glioblastoma', 'Chronic Disease-apply-Obesity', 'Cystic Fibrosis-precede-Infections', 'Cardiovascular Diseases-cause-Diabetes Mellitus', 'Pancreatitis-affect-Glucose Metabolism Disorders', 'Fatigue-managed-Anemia', 'Anemia-prompt-Fatigue', 'Carcinoma, Squamous Cell-present-Head and Neck Neoplasms', 'Cardiovascular Diseases-occur-Hemophilia A', 'Death-understood-Lung Neoplasms', 'Renal Insufficiency-study-Thyroid Diseases', 'Renal Insufficiency-study-Hashimoto Disease', 'Renal Insufficiency-study-Coronary Artery Disease', 'Prostatic Hyperplasia-represent-Urinary Bladder Neoplasms', 'Death-followed-Respiratory Tract Diseases', 'Scleroderma, Systemic-consist-Aneurysm', 'Venous Thromboembolism-excluded-Sleep Initiation and Maintenance Disorders', 'Neoplasms-excluded-Sleep Initiation and Maintenance Disorders', 'Seizures-compare-Psychoses, Substance-Induced', 'Obesity-threaten-Death', 'Metabolic Syndrome-result-Cardiovascular Diseases', 'Metabolic Syndrome-used-Cardiovascular Diseases', 'Metabolic Syndrome-assess-Cardiovascular Diseases', 'Carotid Stenosis-performed-Atherosclerosis', 'Carotid Stenosis-demonstrate-Stroke', 'Atherosclerosis-demonstrate-Stroke', 'Hip Fractures-undergo-Wounds and Injuries', 'Lupus Erythematosus, Systemic-become-Neoplasms', 'Neoplasms-appear-Lupus Erythematosus, Systemic', 'Neoplasms-followed-Digestive System Neoplasms', 'Hypertension-reduce-Retinal Diseases', 'Prostatic Neoplasms-restrain-Heart Arrest', 'Neoplasms-restrain-Heart Arrest', 'Death-classified-Malocclusion', 'Dementia-characterized-Hallucinations', 'Dementia-characterized-Parkinson Disease, Secondary', 'Hip Fractures-treat-Death', 'HIV Infections-come-Hypertension, Pulmonary', 'Acquired Immunodeficiency Syndrome-occur-Neoplasms', 'Coronary Artery Disease-used-Death', 'Coronary Artery Disease-estimate-Death', 'Coronary Artery Disease-used-Myocardial Infarction', 'Coronary Artery Disease-estimate-Myocardial Infarction', 'Arbovirus Infections-facilitate-Drug Hypersensitivity', 'Heart Failure-followed-Death', 'Chronic Disease-contribute-Angina Pectoris', 'Chronic Disease-contribute-Hip Fractures', 'Chronic Disease-contribute-Arthritis', 'Diabetes Mellitus-affected-Infarction', 'Fibrosis-accelerate-HIV Infections', 'HIV Infections-accelerate-Acquired Immunodeficiency Syndrome', 'Opportunistic Infections-represent-Drug-Related Side Effects and Adverse Reactions', 'Opportunistic Infections-represent-Liver Diseases', 'Opportunistic Infections-caused-Chemical and Drug Induced Liver Injury', 'Opportunistic Infections-represent-Death', 'Drug-Related Side Effects and Adverse Reactions-caused-Chemical and Drug Induced Liver Injury', 'Drug-Related Side Effects and Adverse Reactions-represent-Death', 'Death, Sudden, Cardiac-include-Arrhythmias, Cardiac', 'Neoplasms-control-Pain', 'Fractures, Bone-control-Pain', 'Pain-enhance-Breast Neoplasms', 'Melanoma-make-Neoplasms', 'Dermatitis, Irritant-caused-Urinary Incontinence', 'Melanoma-treat-Neoplasm Metastasis', 'Melanoma-distinguish-Neoplasm Metastasis', 'Neoplasms-made-Stomach Neoplasms', 'Infections-focused-Stomach Neoplasms', 'Death, Sudden-follow-Heart Failure', 'Cystic Fibrosis-develop-Colonic Neoplasms', 'Digestive System Neoplasms-increased-Cystic Fibrosis', 'Neoplasms-reported-Glioblastoma', 'Neoplasms-classified-Gastritis', 'Death-avoid-Urinary Incontinence', 'Death-avoid-Erectile Dysfunction', 'Communicable Diseases-recognize-Death', 'Communicable Diseases-recognize-Malnutrition', 'Pain-use-Fatigue', 'Genetic Diseases, Inborn-manifest-Wounds and Injuries', 'Hirschsprung Disease-associated-Congenital Abnormalities', 'Congenital Abnormalities-associated-Hirschsprung Disease', 'Multiple Endocrine Neoplasia Type 1-occur-Neoplasms', 'Melanoma-provide-Neoplasm Metastasis', 'Liver Cirrhosis-explain-Hepatic Encephalopathy', 'Hepatic Insufficiency-explain-Hepatic Encephalopathy', 'Death-show-Colonic Neoplasms', 'Neoplasms-cause-Carcinogenesis', 'Wounds and Injuries-account-Parasitic Diseases', 'Hypertension, Pulmonary-characterized-Hypertension', 'Diabetes Mellitus-receive-Cardiovascular Diseases', 'Metabolic Diseases-unmask-Diabetes, Gestational', 'Metabolic Diseases-unmask-Diabetes Mellitus', 'Diabetes Mellitus-show-Cardiovascular Diseases', 'Multiple Endocrine Neoplasia-receive-Neoplasms', 'HIV Infections-result-Communicable Diseases', 'Inflammation-increase-Hypertension', 'Endocrine Gland Neoplasms-include-Ovarian Neoplasms', 'Dementia-report-Parkinson Disease', 'Lung Neoplasms-followed-Breast Neoplasms', 'Multiple Myeloma-followed-Breast Neoplasms', 'Dementia, Vascular-observed-Alzheimer Disease', 'Death-affect-Hypertension', 'Death-investigate-Diabetes Mellitus', 'Death-assess-Cardiovascular Diseases', 'Enterocolitis, Necrotizing-remain-Death', 'Ovarian Neoplasms-protect-Cardiovascular Diseases', 'Ovarian Neoplasms-result-Heart Diseases', 'Ovarian Neoplasms-result-Death', 'Pulmonary Arterial Hypertension-involve-Cerebrovascular Disorders', 'Adrenal Insufficiency-lead-Arthritis, Rheumatoid', 'Arthritis, Rheumatoid-characterized-Joint Diseases', 'Sclerosis-characterized-Basal Ganglia Cerebrovascular Disease', 'Autoimmune Diseases-characterized-Basal Ganglia Cerebrovascular Disease', 'Autoimmune Diseases-characterized-Fibrosis', 'Cardiovascular Diseases-display-Malnutrition', 'Death-estimate-Kidney Failure, Chronic', 'Renal Insufficiency-estimate-Kidney Failure, Chronic', 'Dementia-reported-Brain Neoplasms', 'Metabolic Diseases-modulate-Inflammation', 'Death-modulate-Inflammation', 'Coronary Artery Disease-use-Diabetes Mellitus', 'Coronary Artery Disease-use-Hypertension', 'Coronary Artery Disease-use-Tuberculosis', 'Coronary Artery Disease-use-Pulmonary Fibrosis', 'Renal Insufficiency, Chronic-avert-Cardiac Complexes, Premature', 'Infarction, Posterior Cerebral Artery-compute-Ischemia', 'Infarction, Posterior Cerebral Artery-compute-Stroke', 'HIV Infections-complete-Neoplasms', 'Multiple Sclerosis-present-Optic Neuritis', 'Multiple Sclerosis-present-Myelitis', 'Multiple Sclerosis-present-Ophthalmoplegia', 'Multiple Sclerosis-defined-Nervous System Diseases', 'Telangiectasia, Hereditary Hemorrhagic-affect-Death', 'Death-measure-Telangiectasia, Hereditary Hemorrhagic', 'Vascular Malformations-associated-Death', 'Death-associated-Vascular Malformations', 'Death-treat-Telangiectasia, Hereditary Hemorrhagic', 'Arteriovenous Malformations-treat-Telangiectasia, Hereditary Hemorrhagic', 'Peripheral Nervous System Diseases-impact-Diabetes Mellitus', 'Anemia-reduce-Telangiectasia, Hereditary Hemorrhagic', 'Death-attributed-Neurotoxicity Syndromes', 'Coronary Artery Disease-evaluate-Death', 'Cardiovascular Diseases-account-Death, Sudden, Cardiac', 'Neurologic Manifestations-considered-Back Pain', 'Skin Diseases-associated-Arthritis, Psoriatic', 'Arthritis, Psoriatic-associated-Skin Diseases', 'Obesity-associated-Arthritis, Psoriatic', 'Arthritis, Psoriatic-associated-Obesity', 'Psoriasis-screened-Arthritis, Psoriatic', 'HIV Infections-include-Bone Diseases', 'Inflammation-include-Bone Diseases', 'Fractures, Bone-include-Bone Diseases', 'Fractures, Bone-include-HIV Infections', 'Death-infer-Pulmonary Disease, Chronic Obstructive', 'Hypertension-preceded-Soft Tissue Injuries', 'Hypertension-recognize-Hypertrophy', 'Hypertension-recognize-Renal Insufficiency, Chronic', 'Hypertrophy-screened-Hypertension', 'Renal Insufficiency, Chronic-screened-Hypertension', 'Sleep Disorders, Circadian Rhythm-considered-Hypertension', 'Inflammation-described-Death', 'Arthritis, Rheumatoid-include-Necrosis', 'Death-present-Heart Failure', 'Diabetes Mellitus, Type 2-found-Dyslipidemias', 'Multiple Sclerosis-drive-Neuroaxonal Dystrophies', 'Diabetes Mellitus, Type 2-known-Dyslipidemias', 'Diabetes Mellitus, Type 2-lead-Diabetes Mellitus', 'Dyslipidemias-known-Atherosclerosis', 'Dyslipidemias-lead-Atherosclerosis', 'Dyslipidemias-known-Diabetes Mellitus', 'Neuroaxonal Dystrophies-induced-Inflammation', 'Cystic Fibrosis-express-Infertility, Female', 'HIV Infections-grow-Rupture', 'Coinfection-grow-Rupture', 'Cardiovascular Diseases-described-HIV Infections', 'Hypertension-follow-Basal Ganglia Cerebrovascular Disease', 'Basal Ganglia Cerebrovascular Disease-involve-Dyslipidemias', 'Basal Ganglia Cerebrovascular Disease-involve-Diabetes Mellitus', 'Aneurysm-range-Atherosclerosis', 'Primary Myelofibrosis-decrease-Polycythemia Vera', 'Primary Myelofibrosis-decrease-Thrombocytosis', 'Abetalipoproteinemia-include-Thrombocythemia, Essential', 'Abetalipoproteinemia-include-Primary Myelofibrosis', 'Pelvic Neoplasms-cause-Urethral Diseases', 'Wounds and Injuries-cause-Urethral Diseases', 'Urethral Diseases-associated-Pelvic Neoplasms', 'Pelvic Neoplasms-associated-Urethral Diseases', 'Urethral Diseases-cause-Pelvic Neoplasms', 'Erectile Dysfunction-encountered-Urethral Diseases', 'Inflammation-stabilize-Wounds and Injuries', 'Inflammation-stabilize-Urethral Stricture', 'Fibrosis-stabilize-Wounds and Injuries', 'Fibrosis-stabilize-Urethral Stricture', 'Joint Diseases-include-Central Nervous System Diseases', 'Joint Diseases-result-Central Nervous System Diseases', 'Prostatic Neoplasms-evolve-Neoplasms', 'Hemiplegia-related-Stroke', 'Prostatic Neoplasms-managed-Small Cell Lung Carcinoma', 'Neoplasms-managed-Small Cell Lung Carcinoma', 'Neoplasms-multiforme-Glioblastoma', 'Epilepsy-undergo-Seizures', 'Heart Defects, Congenital-influence-Death', 'Metabolic Syndrome-diagnose-Diabetes Mellitus', 'Coronary Artery Disease-exclude-Myocardial Infarction', 'Heart Failure-exclude-Coronary Artery Disease', 'Hypertension-exclude-Coronary Artery Disease', 'Aortic Aneurysm-exclude-Coronary Artery Disease', 'Myocardial Infarction-exclude-Hypertension', 'Proteinuria-evaluate-Cystic Fibrosis', 'Kidney Failure, Chronic-evaluate-Cystic Fibrosis', 'Kidney Diseases-reported-Cystic Fibrosis', 'Nephrotic Syndrome-performed-Proteinuria', 'Nephrotic Syndrome-performed-Renal Insufficiency', 'Psoriasis-associated-Myocardial Infarction', 'Myocardial Infarction-associated-Psoriasis', 'Death-decrease-Psoriasis', 'Proteinuria-characterized-Exocrine Pancreatic Insufficiency', 'Proteinuria-characterized-Diabetes Mellitus', 'Hypothalamic Diseases-lead-Obesity', 'Obesity-lead-Craniopharyngioma', 'Metabolic Diseases-reduce-Death', 'Kidney Diseases-classified-Proteinuria', 'Renal Insufficiency, Chronic-classified-Proteinuria', 'Diabetic Nephropathies-amplify-Death', 'Obesity-amplify-Death', 'Death-make-Diabetic Nephropathies', 'Diabetic Nephropathies-defined-Diabetes Mellitus', 'Diabetic Nephropathies-defined-Renal Insufficiency, Chronic', 'Diabetes Mellitus-defined-Renal Insufficiency, Chronic', 'Inflammation-portend-Neoplasms', 'Ehlers-Danlos Syndrome-described-Death', 'Neoplasms-limit-Death', 'Neoplasms-assess-Kidney Neoplasms', 'Neoplasms-assess-Leukemia, Myelogenous, Chronic, BCR-ABL Positive', 'HIV Infections-complicated-Drug-Related Side Effects and Adverse Reactions', 'Ovarian Neoplasms-gain-Breast Neoplasms', 'Neoplasms-report-Sarcoma', 'Sarcoma-report-Neoplasms', 'Hypertension-identify-Coronary Artery Disease', 'Cystic Fibrosis-caused-Airway Obstruction', 'Cystic Fibrosis-caused-Respiratory Insufficiency', 'Infections-treat-Exocrine Pancreatic Insufficiency', 'Infections-result-Cystic Fibrosis', 'Exocrine Pancreatic Insufficiency-result-Cystic Fibrosis', 'Neoplasm Metastasis-discovered-Neoplasms', 'Epidermolysis Bullosa Dystrophica-manifest-Carcinoma, Squamous Cell', 'Parkinson Disease-viewed-Movement Disorders', 'Parkinson Disease-reveal-Death', 'Immunoglobulin Light-chain Amyloidosis-terminated-Arrhythmias, Cardiac', 'Death, Sudden, Cardiac-terminated-Arrhythmias, Cardiac', 'Movement Disorders-reveal-Pain', 'Movement Disorders-reveal-Fatigue', 'Diabetes Mellitus-develop-Diabetic Nephropathies', 'Diabetic Nephropathies-associated-Kidney Failure, Chronic', 'Kidney Failure, Chronic-associated-Diabetic Nephropathies', 'Diabetic Nephropathies-contribute-Hyperglycemia', 'Diabetic Nephropathies-contribute-Hyperlipidemias', 'Diabetic Nephropathies-contribute-Hypertension', 'Diabetic Nephropathies-contribute-Proteinuria', 'Hyperglycemia-contribute-Diabetic Nephropathies', 'Hyperlipidemias-contribute-Diabetic Nephropathies', 'Diabetic Nephropathies-measure-Proteinuria', 'Hypertension-contribute-Diabetic Nephropathies', 'Proteinuria-contribute-Diabetic Nephropathies', 'Neoplasms-indicated-Infections', 'Neoplasms-indicated-Wounds and Injuries', 'Hyperglycemia-reduce-Proteinuria', 'Dysbiosis-made-Arthritis, Rheumatoid', 'Dysbiosis-made-Inflammatory Bowel Diseases', 'Dysbiosis-made-Diabetes Mellitus', 'Melanoma-follow-Hodgkin Disease', 'Carcinogenesis-framed-Neoplasms', 'Adrenal Insufficiency-mark-Obesity', 'Neoplasms-highlight-Carcinogenesis', 'Diabetes Mellitus-include-Autoimmune Diseases', 'Death-involve-Arbovirus Infections', 'Neoplasms-known-Death', 'Dementia-place-Psychomotor Agitation', 'Lung Neoplasms-based-Death', 'Renal Insufficiency, Chronic-reported-Death', 'Myeloproliferative Disorders-studied-Polycythemia Vera', 'Myeloproliferative Disorders-studied-Thrombocytosis', 'Myeloproliferative Disorders-studied-Primary Myelofibrosis', 'Myeloproliferative Disorders-studied-Leukemia, Myelogenous, Chronic, BCR-ABL Positive', 'Fractures, Bone-treat-Osteoarthritis', 'Amyotrophic Lateral Sclerosis-cause-Paralysis', 'Amyotrophic Lateral Sclerosis-followed-Death', 'Neurodegenerative Diseases-cause-Paralysis', 'Neurodegenerative Diseases-followed-Death', 'Thalassemia-acknowledged-Thrombosis', 'Paralysis-followed-Death', 'Chronic Disease-acknowledged-Thrombosis', 'Diabetes Mellitus-share-Cardiovascular Diseases', 'Cardiovascular Diseases-escalate-Diabetes Mellitus', 'Immunologic Deficiency Syndromes-result-Fibrosis', 'Immunologic Deficiency Syndromes-caused-Fibrosis', 'Fibrosis-involved-Cardiomyopathy, Dilated', 'Fibrosis-accompany-Cardiomyopathy, Dilated', 'Fibrosis-involved-Heart Diseases', 'Fibrosis-lead-Heart Diseases', 'Fibrosis-involved-Heart Failure', 'Cardiomyopathy, Dilated-lead-Heart Diseases', 'Heart Failure-promote-Fibrosis', 'Heart Failure-promote-Ventricular Remodeling', 'Lupus Erythematosus, Systemic-increase-Cardiovascular Diseases', 'Lupus Erythematosus, Systemic-produce-Death', 'Liver Diseases-range-Chest Pain', 'Liver Diseases-range-Infections', 'Pain-present-Communicable Diseases', 'Neoplasm Metastasis-occur-Hypoglycemia', 'Infarction, Middle Cerebral Artery-reduce-Infarction', 'Infarction, Middle Cerebral Artery-improve-Neurologic Manifestations', 'Infarction-improve-Neurologic Manifestations', 'Carotid Stenosis-seen-Cerebral Infarction', 'Hypoxia-regulate-Inflammation', 'Kidney Diseases-underlie-Glomerulonephritis', 'Kidney Diseases-underlie-Nephrosclerosis', 'Kidney Diseases-underlie-Diabetic Nephropathies', 'Inflammation-observe-Colitis', 'Neoplasms-cause-Heart Arrest', 'Neoplasms-prolong-Leukemia', 'Prostatic Neoplasms-caused-Death', 'Diabetes Mellitus-calculated-Metabolic Syndrome', 'Heredodegenerative Disorders, Nervous System-characterized-Ataxia', 'Heredodegenerative Disorders, Nervous System-characterized-Muscle Weakness', 'Mitochondrial Diseases-addressed-Cardiomyopathy, Hypertrophic', 'Mitochondrial Diseases-ameliorate-Cardiomyopathy, Hypertrophic', 'Infections-compare-Hepatitis C', 'Death-involve-Acromegaly', 'Anemia-impact-Neoplasms', 'Death-predicted-Dementia', 'Death-predicted-Heart Diseases', 'Death-predicted-Stroke', 'Dementia-find-Death', 'Cardiomyopathies-induce-Death', 'Leukemia-treat-Neoplasms', 'Leukemia-treat-Multiple Sclerosis', 'Muscle Weakness-require-Cough', 'Migraine Disorders-respond-Ovarian Diseases', 'Epilepsy-respond-Ovarian Diseases', 'Muscular Dystrophy, Duchenne-manifest-Cardiomyopathies', 'Drug-Related Side Effects and Adverse Reactions-experience-Anemia', 'Drug-Related Side Effects and Adverse Reactions-experience-Thrombocytopenia', 'Acute Kidney Injury-caused-Kidney Diseases', 'Renal Insufficiency, Chronic-caused-Kidney Diseases', 'Acute Kidney Injury-caused-Opportunistic Infections', 'Kidney Diseases-used-Opportunistic Infections', 'Ganglioglioma-induce-Epilepsy', 'Neoplasms-induce-Epilepsy', 'Renal Insufficiency, Chronic-caused-Glomerulonephritis', 'Renal Insufficiency, Chronic-caused-Thrombotic Microangiopathies', 'Renal Insufficiency, Chronic-lead-Glomerulonephritis', 'Thrombotic Microangiopathies-collapse-Glomerulonephritis', 'Dyslipidemias-increase-Coronary Artery Disease', 'Death-set-Communicable Diseases', 'Death-rise-Communicable Diseases', 'Neoplasms-set-Communicable Diseases', 'Thalassemia-result-Anemia', 'Genetic Diseases, Inborn-result-Anemia', 'Infections-include-HIV Infections', 'Liver Diseases-co-infected-Hepatitis C', 'Hepatitis C-co-infected-Opportunistic Infections', 'Fractures, Bone-couple-Wounds and Injuries', 'Spinal Fractures-contribute-Bone Diseases', 'Bone Neoplasms-contribute-Cardiac Output, Low', 'Death-cause-Breast Neoplasms', 'Epilepsy-value-Seizures', 'Cholestasis, Intrahepatic-related-Cholestasis', 'Cholestasis, Intrahepatic-appear-Cholestasis', 'Fractures, Bone-expect-Lupus Erythematosus, Systemic', 'Lupus Erythematosus, Systemic-associated-Fractures, Bone', 'Fractures, Bone-associated-Lupus Erythematosus, Systemic', 'Stroke-associate-Cardiomyopathy, Hypertrophic', 'Cardiomyopathy, Hypertrophic-associate-Stroke', 'Colitis, Ulcerative-show-Death', 'Death-suggest-Heart Diseases', 'Coronary Artery Disease-suggest-Heart Diseases', 'Cardiovascular Diseases-suggest-Heart Diseases', 'Prostatic Neoplasms-consider-Liver Neoplasms', 'Crohn Disease-show-Death', 'Death-perform-Carotid Stenosis', 'Hemorrhage-started-Thromboembolism', 'Immunologic Deficiency Syndromes-bear-Neoplasms', 'Prostatic Neoplasms-control-Neoplasms', 'Ovarian Diseases-include-Neoplasms', 'Cough-combat-Respiratory Tract Infections', 'Cough-combat-Lung Diseases', 'Respiratory Tract Infections-combat-Lung Diseases', 'Muscular Diseases-figure-Muscular Dystrophy, Duchenne', 'Drug Hypersensitivity-include-Muscular Dystrophy, Duchenne', 'Myelodysplastic Syndromes-develop-Leukemia', 'Hematologic Diseases-develop-Leukemia, Myeloid, Acute', 'Hematologic Diseases-develop-Leukemia', 'Leukemia, Myeloid, Acute-develop-Leukemia, Myelomonocytic, Chronic', 'Death-ascertained-Prostatic Neoplasms', 'Immunologic Deficiency Syndromes-diagnosed-Pneumonia, Pneumocystis', 'Arrhythmias, Cardiac-worsen-Heart Diseases', 'Ventricular Fibrillation-occur-Arrhythmias, Cardiac', 'Leukemia, Myelogenous, Chronic, BCR-ABL Positive-marked-Multiple Myeloma', 'Leukemia, Myelogenous, Chronic, BCR-ABL Positive-marked-Leukemia, Myeloid, Acute', 'Multiple Myeloma-exist-Leukemia, Myelogenous, Chronic, BCR-ABL Positive', 'Myocardial Infarction-appear-Death', 'Arrhythmias, Cardiac-appear-Death', 'Multiple Myeloma-suggest-Neoplasms', 'Cardiovascular Diseases-account-Arthritis, Rheumatoid', 'Death-raised-Hypopituitarism', 'Death-raised-Pituitary Neoplasms', 'Neoplasms-diagnosed-Scleroderma, Localized', 'Scleroderma, Localized-diagnosed-Prostatic Neoplasms', 'Scleroderma, Localized-diagnosed-Death', 'Diabetic Nephropathies-lead-Kidney Diseases', 'Diabetic Nephropathies-lead-Death', 'Neoplasms-account-Cardiovascular Diseases', 'Arthritis, Rheumatoid-affect-Synovial Cyst', 'Neuromuscular Junction Diseases-underpinn-Sarcopenia', 'Cerebrovascular Disorders-associated-Breast Neoplasms', 'Breast Neoplasms-associated-Cerebrovascular Disorders', 'Cerebrovascular Disorders-associated-Drug-Related Side Effects and Adverse Reactions', 'Drug-Related Side Effects and Adverse Reactions-associated-Cerebrovascular Disorders', 'Parkinson Disease-related-Mitochondrial Diseases', 'Osteoporosis-lead-Spinal Diseases', 'Nerve Degeneration-decrease-Inflammation', 'Stroke-performed-Hypertension', 'Stroke-performed-Diabetes Mellitus', 'Hand Injuries-experience-Dementia', 'Hypoxia-approved-Anemia', 'Motor Neuron Disease-lead-Muscular Diseases', 'Paralysis-caused-Spinal Cord Injuries', 'Heredodegenerative Disorders, Nervous System-lead-Muscular Diseases', 'Neurodegenerative Diseases-accelerated-Nervous System Diseases', 'Leukemia, Myeloid, Accelerated Phase-accelerate-Amyotrophic Lateral Sclerosis', 'Death-cause-Aortic Aneurysm, Abdominal', 'Multiple Myeloma-manage-Pain', 'Psychoses, Substance-Induced-diagnosed-Dementia', 'Gynecomastia-depicted-Fibrosis', 'Polyps-complicated-Hemorrhage', 'Hypertension-lead-Albuminuria', 'Diabetes Mellitus-lead-Albuminuria', 'Albuminuria-share-Atherosclerosis', 'Alexander Disease-experience-Seizures', 'Epilepsy-control-Alexander Disease', 'Pancreatic Neoplasms-found-Cystic Fibrosis', 'Respiratory Tract Diseases-detected-Cystic Fibrosis', 'Diabetes Mellitus-followed-Dyslipidemias', 'Peripheral Arterial Disease-associated-Vascular Calcification', 'Vascular Calcification-associated-Peripheral Arterial Disease', 'Peripheral Arterial Disease-associated-Metabolic Syndrome', 'Metabolic Syndrome-associated-Peripheral Arterial Disease', 'Vascular Calcification-associated-Metabolic Syndrome', 'Metabolic Syndrome-associated-Vascular Calcification', 'Hypoglycemia-decrease-Acute Disease', 'Acidosis-decrease-Acute Disease', 'Muscle Hypotonia-result-Respiratory Insufficiency', 'Muscular Diseases-result-Respiratory Insufficiency', 'Arthritis, Rheumatoid-associated-Drug-Related Side Effects and Adverse Reactions', 'Drug-Related Side Effects and Adverse Reactions-associated-Arthritis, Rheumatoid', 'Headache Disorders, Secondary-undergo-Pituitary Neoplasms', 'Papillomavirus Infections-play-Neoplasms', 'Mitochondrial Diseases-promote-Cardiovascular Diseases', 'Neuroblastoma-reveal-Drug-Related Side Effects and Adverse Reactions', 'Death-made-Hypertension', 'Diabetes Mellitus-evaluate-Leukemia, Lymphocytic, Chronic, B-Cell', 'Diabetes Mellitus-correlated-Leukemia, Lymphocytic, Chronic, B-Cell', 'Brain Neoplasms-known-Headache Disorders, Secondary', 'Brain Neoplasms-give-Headache Disorders, Secondary', 'Thyroiditis, Autoimmune-evaluate-Gastritis', 'Osteogenesis Imperfecta-improve-Osteoporosis', 'Musculoskeletal Diseases-offset-Heart Diseases', 'Death-show-Sepsis', 'Seizures-increase-Neoplasms', 'Diabetes Mellitus-use-Malocclusion', 'Muscular Atrophy, Spinal-develop-Hypoventilation', 'Muscular Atrophy, Spinal-develop-Respiratory Aspiration', 'Parkinson Disease-reduce-Olfaction Disorders', 'Muscular Atrophy, Spinal-develop-Respiratory Tract Infections', 'Muscular Atrophy, Spinal-develop-Deglutition Disorders', 'Neoplasms-induce-Cardiotoxicity', 'Muscular Atrophy, Spinal-develop-Respiratory Insufficiency', 'Neoplasms-differ-Cardiotoxicity', 'Muscular Atrophy, Spinal-develop-Death', 'Heart Diseases-present-Neurotoxicity Syndromes', 'Heart Diseases-result-Pain', 'Neoplasms-exhibit-Drug-Related Side Effects and Adverse Reactions', 'Prader-Willi Syndrome-include-Muscle Hypotonia', 'Prader-Willi Syndrome-include-Growth Disorders', 'Prader-Willi Syndrome-include-Obesity', 'Genetic Diseases, Inborn-include-Muscle Hypotonia', 'Hypertension-decrease-Sleep Wake Disorders', 'Genetic Diseases, Inborn-include-Growth Disorders', 'Genetic Diseases, Inborn-include-Obesity', 'Breast Neoplasms-remain-Drug-Related Side Effects and Adverse Reactions', 'Stomach Neoplasms-defined-Neoplasms', 'Pancreatic Neoplasms-arise-Hereditary Breast and Ovarian Cancer Syndrome', 'Pancreatitis-come-Neoplasms', 'Diabetes Mellitus-come-Neoplasms', 'Wounds and Injuries-characterise-Atrial Fibrillation', 'Hypereosinophilic Syndrome-represent-Inflammation', 'Motor Neuron Disease-ameliorate-Amyotrophic Lateral Sclerosis', 'Communicable Diseases-documented-Rheumatic Diseases', 'Communicable Diseases-documented-Arthritis, Rheumatoid', 'Cardiovascular Diseases-documented-Rheumatic Diseases', 'Cardiovascular Diseases-documented-Arthritis, Rheumatoid', 'Autoimmune Diseases-characterized-Microvascular Angina', 'Cardiovascular Diseases-review-Communicable Diseases', 'Urinary Bladder, Neurogenic-result-Renal Insufficiency', 'Gastrointestinal Diseases-increase-Death', 'Death-explained-Lung Neoplasms', 'Death-explained-Heart Diseases', 'Neurologic Manifestations-related-Brain Injuries, Traumatic', 'Adrenocortical Carcinoma-decline-Death', 'Osteoporosis-instituted-Fractures, Bone', 'Skin Diseases-associated-Kidney Failure, Chronic', 'Kidney Failure, Chronic-associated-Skin Diseases', 'Hemophilia A-infected-Hepatitis, Viral, Human', 'Headache Disorders, Secondary-guarantee-Fractures, Bone', 'Atherosclerosis-play-Psoriasis', 'Neoplasms-introduced-Obesity', 'Neuronal Ceroid-Lipofuscinoses-characterized-Heart Failure', 'Neuronal Ceroid-Lipofuscinoses-characterized-Myoclonus', 'Neuronal Ceroid-Lipofuscinoses-characterized-Dementia', 'Neurodegenerative Diseases-characterized-Heart Failure', 'Neurodegenerative Diseases-characterized-Myoclonus', 'Lysosomal Storage Diseases-characterized-Dementia', 'Drug-Related Side Effects and Adverse Reactions-combine-Glioma', 'Drug-Related Side Effects and Adverse Reactions-include-Hypertension', 'Mastocytosis-classified-Neoplasms', 'Osteoporosis-evaluated-Low Back Pain', 'Cardiovascular Diseases-increase-Hemorrhage', 'Muscular Diseases-include-Atrial Fibrillation', 'Muscular Diseases-include-Atrial Flutter', 'Muscular Diseases-include-Sick Sinus Syndrome', 'Muscular Diseases-include-Atrioventricular Block', 'Muscular Diseases-include-Tachycardia, Ventricular', 'HIV Infections-result-Tuberculosis', 'Coronary Artery Disease-recommend-Colorectal Neoplasms', 'Heredodegenerative Disorders, Nervous System-associated-Muscle Weakness', 'Muscle Weakness-associated-Heredodegenerative Disorders, Nervous System', 'Heredodegenerative Disorders, Nervous System-associated-Atrophy', 'Atrophy-associated-Heredodegenerative Disorders, Nervous System', 'Paraplegia-associated-Quadriplegia', 'Quadriplegia-associated-Paraplegia', 'Paraplegia-associated-Sepsis', 'Sepsis-associated-Paraplegia', 'Paraplegia-associated-Coronary Artery Disease', 'Coronary Artery Disease-associated-Paraplegia', 'Paraplegia-associated-Neoplasms', 'Neoplasms-associated-Paraplegia', 'Paraplegia-associated-Cerebrovascular Disorders', 'Cerebrovascular Disorders-associated-Paraplegia', 'Paraplegia-associated-Heart Diseases', 'Heart Diseases-associated-Paraplegia', 'Quadriplegia-associated-Sepsis', 'Sepsis-associated-Quadriplegia', 'Quadriplegia-associated-Coronary Artery Disease', 'Coronary Artery Disease-associated-Quadriplegia', 'Quadriplegia-associated-Neoplasms', 'Neoplasms-associated-Quadriplegia', 'Atherosclerosis-become-Death', 'Atherosclerosis-fall-Acquired Immunodeficiency Syndrome', 'Death-fall-Acquired Immunodeficiency Syndrome', 'HIV Infections-fall-Acquired Immunodeficiency Syndrome', 'Hernia, Ventral-indicated-Neoplasm Metastasis', 'Amyotrophic Lateral Sclerosis-considered-Genetic Diseases, Inborn', 'Neoplasm Metastasis-given-Neurologic Manifestations', 'Coronary Artery Disease-become-HIV Infections', 'Death-identify-Neoplasms', 'Diabetes Mellitus-ruled-Fatty Liver', 'Fatty Liver-undergo-Liver Diseases', 'Fatty Liver-evaluated-Carcinoma, Hepatocellular', 'Carcinoma, Non-Small-Cell Lung-suffer-Drug-Related Side Effects and Adverse Reactions', 'Atherosclerosis-assess-Cerebral Hemorrhage', 'Cerebrovascular Disorders-recognized-Arteritis', 'Cerebrovascular Disorders-recognized-Intracranial Arteriosclerosis', 'Fetal Death-amount-Death', 'Intracranial Arteriosclerosis-associated-Metabolic Diseases', 'Metabolic Diseases-associated-Intracranial Arteriosclerosis', 'Death-occur-Hepatitis', 'Death-occur-Carcinoma, Hepatocellular', 'Death-occur-Cholestasis', 'Neoplasms-represent-Multiple Endocrine Neoplasia', 'Hip Fractures-justify-Osteoporosis', 'Skin Neoplasms-reduced-Neoplasm Metastasis', 'Death-include-Rupture', 'Carcinoma, Hepatocellular-complicate-Chemical and Drug Induced Liver Injury', 'Mesothelioma-present-Pleural Effusion', 'Inflammation-associated-Epilepsy, Benign Neonatal', 'Epilepsy, Benign Neonatal-associated-Inflammation', 'Coronary Artery Disease-report-Hodgkin Disease', 'Renal Artery Obstruction-control-Hypertension', 'Myocardial Infarction-result-Hypertension', 'Metabolic Syndrome-assess-Obesity', 'Adrenal Insufficiency-exhibit-Spinocerebellar Degenerations', 'Coronary Artery Disease-develop-Kidney Diseases', 'Coronary Artery Disease-detect-Kidney Diseases', 'Neoplasms-comprise-Brain Neoplasms', 'Breast Neoplasms-occur-Myocardial Infarction', 'Breast Neoplasms-occur-Hip Fractures', 'Fractures, Bone-evaluate-Osteoporosis', 'Osteoporosis-reflected-Muscular Dystrophy, Duchenne', 'Osteoporosis-reflected-Fractures, Bone', 'Muscular Dystrophy, Duchenne-reflected-Fractures, Bone', 'Invasive Pulmonary Aspergillosis-diagnosed-Acquired Immunodeficiency Syndrome', 'Death-suggest-Aneurysm', 'Cardiomyopathy, Dilated-associated-Mitral Valve Insufficiency', 'Mitral Valve Insufficiency-associated-Cardiomyopathy, Dilated', 'Osteoporosis-diagnosed-Polyneuropathies', 'Cardiomyopathy, Dilated-associated-Kidney Diseases', 'Kidney Diseases-associated-Cardiomyopathy, Dilated', 'Anemia-result-Cardiotoxicity', 'Adenocarcinoma-include-Carcinoma, Squamous Cell', 'Adenocarcinoma-include-Lung Neoplasms', 'Fibrosis-characterized-Hyperplasia', 'Splenomegaly-minimize-Pain', 'Lymphoproliferative Disorders-minimize-Pain', 'Myeloproliferative Disorders-minimize-Pain', 'Fibrosis-regarded-Myelodysplastic Syndromes', 'Cell Transformation, Viral-occur-Fibrosis', 'Necrosis-involve-Retinal Detachment', 'Anemia, Sickle Cell-occur-Death', 'Acute Chest Syndrome-associated-Death', 'Death-associated-Acute Chest Syndrome', 'Seizures-calculated-Hemophilia A', 'Neoplasms-found-Adenocarcinoma of Lung', 'Stroke-eliminate-Death', 'Death-cited-Cerebrovascular Disorders', 'Neoplasms-induce-Carcinogenesis', 'Cerebrovascular Disorders-constructed-Death', 'Melanoma-identified-Gastrointestinal Diseases', 'Melanoma-identified-Death', 'Gastrointestinal Diseases-identified-Death', 'Hydrocephalus-diagnosed-Walker-Warburg Syndrome', 'Microphthalmos-diagnosed-Walker-Warburg Syndrome', 'Muscular Diseases-diagnosed-Walker-Warburg Syndrome', 'Abnormalities, Drug-Induced-diagnosed-Walker-Warburg Syndrome', 'Renal Artery Obstruction-treat-Hypertension', 'Ischemia-based-Infarction', 'Ischemia-lost-Infarction', 'Neoplasms-play-Carcinogenesis', 'Diabetes Mellitus-control-Hypotension', 'Death-reduce-Acquired Immunodeficiency Syndrome', 'Neoplasms-protect-Death', 'Neoplasms-protect-Neoplasm Metastasis', 'Death-protect-Neoplasm Metastasis', 'Pneumonia-investigate-Dementia', 'Neurodegenerative Diseases-determine-Atrophy', 'Coronary Artery Disease-follow-Lung Neoplasms', 'Neoplasms-treat-Sarcoma', 'Diabetes Mellitus-combined-Dyslipidemias', 'Lupus Erythematosus, Systemic-reduce-Atherosclerosis', 'Acute Coronary Syndrome-manage-Hemophilia A', 'Lupus Erythematosus, Systemic-harbor-Atherosclerosis', 'Cardiovascular Diseases-involve-Hypertension', 'Liver Diseases-associate-Death', 'Death-associate-Liver Diseases', 'Arthritis, Rheumatoid-involve-Arthralgia', 'Arthritis, Rheumatoid-involve-Fatigue', 'Parkinson Disease-show-Nervous System Diseases', 'Epilepsy, Benign Neonatal-protected-Atherosclerosis', 'Epilepsy, Benign Neonatal-defined-Atherosclerosis', 'Obesity-related-Musculoskeletal Pain', 'Obesity-contribute-Musculoskeletal Pain', 'Obesity-related-Pain', 'Obesity-contribute-Pain', 'Hemoglobinopathies-include-Genetic Diseases, Inborn', 'HIV Infections-switch-Opportunistic Infections', 'HIV Infections-switch-Cardiovascular Diseases', 'Opportunistic Infections-switch-Cardiovascular Diseases', 'Death-drawn-Ovarian Neoplasms', 'HIV Infections-lead-Chemical and Drug Induced Liver Injury', 'Ovarian Neoplasms-induce-Death', 'HIV Infections-lead-Fibrosis', 'HIV Infections-implicated-Hepatitis, Viral, Human', 'HIV Infections-implicated-Liver Diseases', 'Mitochondrial Diseases-affect-Neurodegenerative Diseases', 'Mitochondrial Diseases-affect-Neoplasms', 'Myeloproliferative Disorders-comprise-Polycythemia Vera', 'Myeloproliferative Disorders-comprise-Essential Tremor', 'Myeloproliferative Disorders-comprise-Primary Myelofibrosis', 'Hypokinesia-seen-Parkinson Disease', 'Muscle Rigidity-seen-Parkinson Disease', 'Parkinson Disease-seen-Nervous System Diseases', 'Parkinson Disease-seen-Ataxia', 'Parkinson Disease-seen-Dementia', 'Inflammation-reduce-Neoplasms', 'Heart Failure-characterize-Edema', 'Prostatic Neoplasms-respond-Oculocerebrorenal Syndrome', 'Prostatic Neoplasms-respond-Neoplasms', 'Cardiomyopathy, Dilated-alter-Edema', 'Death-obtained-Dementia', 'Dementia-modeling-Death', 'Immunologic Deficiency Syndromes-characterize-Infections', 'Infections-characterize-Autoimmune Diseases', 'Cerebral Infarction-develop-Alzheimer Disease', 'Gallstones-increase-Obesity', 'Inflammation-associate-Obesity', 'Obesity-associate-Inflammation', 'Inflammation-impact-Obesity', 'Hypothalamic Diseases-implicated-Hyperphagia', 'Hypothalamic Diseases-implicated-Pain', 'Hypothalamic Diseases-implicated-Sleep Wake Disorders', 'Hypothalamic Diseases-implicated-Endocrine System Diseases', 'Prader-Willi Syndrome-implicated-Endocrine System Diseases', 'Prader-Willi Syndrome-characterized-Muscle Hypotonia', 'Adrenal Insufficiency-complicated-Diabetes Mellitus', 'Prader-Willi Syndrome-characterized-Intellectual Disability', 'Hypogonadism-complicated-Diabetes Mellitus', 'Prader-Willi Syndrome-characterized-Congenital Abnormalities', 'Hypothyroidism-complicated-Diabetes Mellitus', 'Prader-Willi Syndrome-characterized-Obesity', 'Genetic Diseases, Inborn-characterized-Muscle Hypotonia', 'Genetic Diseases, Inborn-characterized-Intellectual Disability', 'Genetic Diseases, Inborn-characterized-Congenital Abnormalities', 'Genetic Diseases, Inborn-characterized-Obesity', 'Thalassemia-emerge-Hypothyroidism', 'Thalassemia-emerge-Thyroid Neoplasms', 'Thalassemia-emerge-Latent Tuberculosis', 'Coronary Artery Disease-impact-Death', 'Inflammation-tackle-Infections', 'Death-use-Colitis, Ulcerative', 'Inflammatory Bowel Diseases-decrease-Death', 'Death-use-Crohn Disease', 'Death-use-Inflammatory Bowel Diseases', 'Colitis, Ulcerative-increased-Inflammatory Bowel Diseases', 'Crohn Disease-increased-Inflammatory Bowel Diseases', 'Alzheimer Disease-delay-Nervous System Diseases', 'Prostatic Neoplasms-expected-Renal Insufficiency', 'Alzheimer Disease-delay-Cardiovascular Diseases', 'Heart Diseases-complicated-Infections', 'Brain Abscess-maintain-Hypoplastic Left Heart Syndrome', 'Shock, Cardiogenic-measure-Neoplasms', 'Cystic Fibrosis-impact-Thrombosis', 'Cystic Fibrosis-impact-Malabsorption Syndromes', 'Thrombosis-impact-Malabsorption Syndromes', 'Heart Diseases-used-Neoplasms', 'beta-Thalassemia-function-Thalassemia', 'Infections-function-Thalassemia', 'Stroke-require-Atrioventricular Block', 'Neoplasms-treat-Cardiomyopathies', 'Myelodysplastic Syndromes-characterized-Peripheral Nervous System Diseases', 'Myelodysplastic Syndromes-characterized-Anemia', 'Hematologic Neoplasms-characterized-Peripheral Nervous System Diseases', 'Hematologic Neoplasms-characterized-Anemia', 'Dermatitis-associated-Neoplasms', 'Neoplasms-associated-Dermatitis', 'Genetic Diseases, Inborn-efface-Neoplasms', 'Graft vs Host Disease-efface-Neoplasms', 'Neoplasms-efface-Lymphoma, B-Cell', 'Hemophilia A-change-Hemorrhage', 'Hemophilia A-related-Death', 'Hemophilia A-indicate-Death', 'Heart Failure-analysed-Death', 'Respiratory Insufficiency-analysed-Death', 'Pneumonia-analysed-Death', 'Epilepsy-analysed-Death', 'Diabetes Mellitus-remain-Kidney Failure, Chronic', 'Neurodegenerative Diseases-characterized-Respiratory Paralysis', 'Obesity-report-Seizures', 'Pituitary Neoplasms-achieve-Neoplasms', 'Hemorrhage-run-Aortic Valve Insufficiency', 'Duodenal Obstruction-use-Pancreatic Neoplasms', 'Hypertrophy, Left Ventricular-remain-Kidney Failure, Chronic', 'Hypertrophy, Left Ventricular-caused-Renal Insufficiency, Chronic', 'Kidney Failure, Chronic-caused-Renal Insufficiency, Chronic', 'Hypertension-caused-Renal Insufficiency, Chronic', 'Immunologic Deficiency Syndromes-develop-Anemia, Aplastic', 'Immunologic Deficiency Syndromes-develop-Pulmonary Fibrosis', 'Immunologic Deficiency Syndromes-develop-Fibrosis', 'Immunologic Deficiency Syndromes-develop-Emphysema', 'Anemia, Aplastic-develop-Hematologic Neoplasms', 'Anemia, Aplastic-develop-Emphysema', 'Pulmonary Fibrosis-develop-Hematologic Neoplasms', 'Pulmonary Fibrosis-develop-Emphysema', 'Fibrosis-develop-Hematologic Neoplasms', 'Fibrosis-develop-Emphysema', 'Hematologic Neoplasms-develop-Emphysema', 'Weight Loss-increase-Inflammation', 'Death-based-Diabetes Mellitus', 'Cardiovascular Diseases-based-Diabetes Mellitus', 'Cardiovascular Diseases-obtained-Diabetes Mellitus', 'Diabetes Mellitus-based-Blindness', 'Drug-Related Side Effects and Adverse Reactions-limited-Pneumonia, Pneumocystis', 'Neoplasms-include-Hernia, Hiatal', 'Chemical and Drug Induced Liver Injury-become-Death', 'Death-result-Coronary Artery Disease', 'Keratitis, Dendritic-given-Ovarian Diseases', 'Death-found-Glaucoma', 'Diabetes Mellitus-evaluate-Diabetes Mellitus, Type 1', 'Diabetes Mellitus-take-Cataract', 'Cataract-take-Diabetes Mellitus', 'Macular Degeneration-identified-Blindness', 'Onycholysis-used-Diabetes Mellitus', 'Onycholysis-predict-Diabetes Mellitus', 'Macular Degeneration-identified-Cataract', 'Chronic Disease-characterized-Cardiovascular Diseases', 'Parkinson Disease-show-Disorders of Excessive Somnolence', 'Parkinson Disease-show-Hallucinations', 'Hemophilia A-occur-Wounds and Injuries', 'Neurodegenerative Diseases-treat-Nerve Degeneration', 'Hemorrhage-cause-Thrombosis', 'Metabolic Diseases-characterized-Nerve Degeneration', 'Leukodystrophy, Metachromatic-include-Lysosomal Storage Diseases', 'Nerve Degeneration-include-Lysosomal Storage Diseases', 'Multiple Sclerosis-include-Lysosomal Storage Diseases', 'Stroke-include-Lysosomal Storage Diseases', 'Spinal Cord Injuries-include-Lysosomal Storage Diseases', 'Myasthenia Gravis-characterized-Muscle Weakness', 'Autoimmune Diseases-characterized-Muscle Weakness', 'Infections-treat-Pseudomonas Infections', 'Cardiovascular Diseases-adjusted-Death', 'Paralysis-end-Death', 'Neoplasm Metastasis-differ-Neoplasms', 'Essential Tremor-increase-Leukemia, Myeloid, Acute', 'Essential Tremor-give-Ulcer', 'Leukemia, Myeloid, Acute-give-Ulcer', 'Bone Diseases, Metabolic-include-Cholangitis', 'Neoplasms-include-Cholangitis', 'Cholangiocarcinoma-include-Cholangitis', 'Liver Diseases-characterized-Fibrosis', 'Meibomian Gland Dysfunction-present-Muscle Weakness', 'Myasthenic Syndromes, Congenital-involve-Ophthalmoplegia', 'Lambert-Eaton Myasthenic Syndrome-involve-Ophthalmoplegia', 'Botulism-involve-Ophthalmoplegia', 'Mitochondrial Diseases-involve-Ophthalmoplegia', 'Guillain-Barre Syndrome-involve-Mitochondrial Diseases', 'Motor Neuron Disease-involve-Mitochondrial Diseases', 'Ischemia-involve-Mitochondrial Diseases', 'Ophthalmoplegia-involve-Guillain-Barre Syndrome', 'Ophthalmoplegia-involve-Motor Neuron Disease', 'Ophthalmoplegia-involve-Ischemia', 'Communicable Diseases-detect-Polycystic Ovary Syndrome', 'Communicable Diseases-detect-Diabetes Mellitus, Type 2', 'Stroke-select-Dementia', 'Stroke-move-Dementia', 'Stroke-manifest-Dementia', 'Death-obtained-Lung Neoplasms', 'Death-obtained-Coronary Artery Disease', 'Arthritis, Rheumatoid-alter-Lung Neoplasms', 'Death-obtained-Testicular Neoplasms', 'Death-obtained-Breast Neoplasms', 'Superior Vena Cava Syndrome-associated-Neoplasms', 'Neoplasms-associated-Superior Vena Cava Syndrome', 'Lung Neoplasms-compare-Arthritis, Rheumatoid', 'Arthritis, Rheumatoid-noted-Pulmonary Fibrosis', 'Lung Neoplasms-noted-Pulmonary Fibrosis', 'Pain-seen-Neoplasms', 'Fatigue-seen-Neoplasms', 'Cholecystitis, Acute-develop-Neoplasms', 'Dementia-include-Ulcer', 'Dementia-include-Constipation', 'Dementia-include-Dyspnea', 'Peripheral Arterial Disease-treated-Coronary Artery Disease', 'Peripheral Arterial Disease-associated-Ischemia', 'Ischemia-associated-Peripheral Arterial Disease', 'Pain-threatening-Ischemia', 'Ulcer-threatening-Ischemia', 'Arteriosclerosis-indicate-Hypertension, Pulmonary', 'Death-covered-Neoplasms', 'Death-increased-Fibrosis', 'Kidney Failure, Chronic-screen-Neoplasms', 'Diabetes Mellitus-followed-Carcinoma, Hepatocellular', 'Cardiomyopathies-followed-Carcinoma, Hepatocellular', 'Liver Cirrhosis-followed-Carcinoma, Hepatocellular', 'Diabetes Mellitus-incorporate-Myocardial Infarction', 'Diabetes Mellitus-incorporate-Kidney Diseases', 'Diabetes Mellitus-incorporate-Retinal Diseases', 'Metabolic Syndrome-termed-Lipodystrophy', 'Metabolic Syndrome-described-HIV Infections', 'Lipodystrophy-described-HIV Infections', 'Death-related-Stomach Neoplasms', 'Fractures, Bone-suffer-Bone Neoplasms', 'Fractures, Bone-suffer-Hypogonadism', 'Bone Diseases, Metabolic-suffer-Bone Neoplasms', 'Bone Diseases, Metabolic-suffer-Hypogonadism', 'Death-elevated-Shock', 'Ulcer-remain-Gastroesophageal Reflux', 'Hemorrhage-reveal-Fatigue', 'Airway Obstruction-reveal-Fatigue', 'Peritoneal Neoplasms-reveal-Fatigue', 'Hepatitis C-minimized-Death', 'Coinfection-minimized-Death', 'Infections-function-Neoplasms', 'Infections-function-Death', 'Neoplasms-function-Death', 'Death-calculated-Osteoarthritis', 'Death-calculated-Arthritis, Rheumatoid', 'Spinal Cord Injuries-expected-Neoplasms', 'Spinal Cord Injuries-increase-Death', 'Neoplasm Metastasis-produce-Vision Disorders', 'Neoplasm Metastasis-produce-Glaucoma', 'Neoplasm Metastasis-produce-Pain', 'Anemia, Hemolytic-reported-HIV Infections', 'Purpura, Thrombotic Thrombocytopenic-reported-HIV Infections', 'Thrombotic Microangiopathies-reported-HIV Infections', 'Thrombotic Microangiopathies-associated-HIV Infections', 'HIV Infections-associated-Thrombotic Microangiopathies', 'Anemia, Hemolytic-added-Acquired Immunodeficiency Syndrome', 'Purpura, Thrombotic Thrombocytopenic-added-Acquired Immunodeficiency Syndrome', 'Thrombocytosis-labeled-Primary Myelofibrosis', 'Leukemia-labeled-Primary Myelofibrosis', 'Polycythemia Vera-labeled-Primary Myelofibrosis', 'Polycystic Kidney Diseases-associated-Intracranial Aneurysm', 'Intracranial Aneurysm-associated-Polycystic Kidney Diseases', 'Polycystic Kidney Diseases-associated-Subarachnoid Hemorrhage', 'Subarachnoid Hemorrhage-associated-Polycystic Kidney Diseases', 'Cerebrovascular Disorders-specify-Subarachnoid Hemorrhage', 'Nervous System Diseases-provide-Polycystic Kidney Diseases', 'Death-associated-Polycystic Kidney Diseases', 'Polycystic Kidney Diseases-associated-Death', 'Aneurysm, Ruptured-associated-Subarachnoid Hemorrhage', 'Subarachnoid Hemorrhage-associated-Aneurysm, Ruptured', 'Hyperplasia-identified-Papilloma', 'Mastitis-characterize-Papilloma', 'Hyperplasia-develop-Breast Neoplasms', 'Digestive System Neoplasms-occur-Colorectal Neoplasms', 'Digestive System Neoplasms-occur-Cholangiocarcinoma', 'Breast Neoplasms-subjected-Muscle Rigidity', 'Liver Diseases-lead-Arbovirus Infections', 'Liver Diseases-lead-Alcoholism', 'Neoplasms-tested-Urinary Bladder Neoplasms', 'Dyspnea-decrease-Hypertension, Pulmonary', 'Leukemia, Lymphocytic, Chronic, B-Cell-improve-Adrenocortical Hyperfunction', 'Leukemia, Myelogenous, Chronic, BCR-ABL Positive-improve-Adrenocortical Hyperfunction', 'Death-result-Renal Insufficiency', 'Stroke-result-Renal Insufficiency', 'Uremia-result-Renal Insufficiency', 'Sepsis-result-Renal Insufficiency', 'Renal Artery Obstruction-result-Renal Insufficiency', 'Nephrosis, Lipoid-include-Diabetes Mellitus', 'Chronic Disease-applied-Diabetes Mellitus', 'Pelvic Neoplasms-undergo-Cutaneous Fistula', 'Cutaneous Fistula-provide-Cerebrospinal Fluid Leak', 'Asbestosis-registered-Death', 'Death-classified-Diabetes Mellitus', 'Death-recorded-Diabetes Mellitus', 'Diabetes Mellitus-induce-Aneurysm', 'Death-came-Coronary Artery Disease', 'Death-came-Stroke', 'Cystic Fibrosis-affect-Lung Diseases', 'Fever-treat-Neoplasms', 'Asthma-treat-Neoplasms', 'Infections-treat-Dysentery', 'Fever-treat-Dysentery', 'Asthma-treat-Dysentery', 'Infections-treat-Malaria', 'Fever-treat-Malaria', 'Asthma-treat-Malaria', 'Dementia-receive-Breast Neoplasms', 'Infections-treat-Diarrhea', 'Fever-treat-Diarrhea', 'Asthma-treat-Diarrhea', 'Infections-treat-Myalgia', 'Fever-treat-Myalgia', 'Asthma-treat-Myalgia', 'Glioblastoma-classified-Glioma', 'Dementia-screened-Breast Neoplasms', 'Dementia-screened-Prostatic Neoplasms', 'Infant, Newborn, Diseases-followed-Coronary Artery Disease', 'Infant, Newborn, Diseases-followed-Stroke', 'Infant, Newborn, Diseases-followed-Communicable Diseases', 'Dementia-associated-Breast Neoplasms', 'Breast Neoplasms-associated-Dementia', 'Dementia-associated-Prostatic Neoplasms', 'Prostatic Neoplasms-associated-Dementia', 'Dementia-receive-Prostatic Neoplasms', 'Dementia-make-Neoplasms', 'Communicable Diseases-followed-Death', 'Respiratory Tract Infections-followed-Death', 'Lung Neoplasms-seem-Death', 'Infections-represent-Hip Fractures', 'Pain-find-Death', 'Pain-use-Death', 'Vision Disorders-used-Blindness', 'Neoplasms-classify-Obesity', 'Neoplasms-classify-Multiple Myeloma', 'Neoplasms-classify-Pancreatitis', 'Neoplasms-classify-Ovarian Diseases', 'Heart Diseases-compare-Wounds and Injuries', 'Heart Diseases-mediate-Wounds and Injuries', 'Heredodegenerative Disorders, Nervous System-influence-Neurodegenerative Diseases', 'Acquired Immunodeficiency Syndrome-translate-Death', 'Hypospadias-considered-Neoplasms', 'Cryptorchidism-considered-Neoplasms', 'Inflammation-resemble-Prostatitis', 'Inflammation-resemble-Prostatic Neoplasms', 'Prostatitis-play-Prostatic Neoplasms', 'Ovarian Neoplasms-considered-Neoplasms', 'Parkinson Disease-discussed-Dementia', 'Cardiomyopathies-reduce-Cardiovascular Diseases', 'Epilepsy, Tonic-Clonic-result-Death', 'Neoplasms-represent-Brain Neoplasms', 'Neoplasms-targeted-Carcinoma, Papillary', 'Carcinoma, Papillary-targeted-Craniopharyngioma', 'Primary Dysautonomias-reported-Hypoventilation', 'Primary Dysautonomias-reported-Obesity', 'Neoplasms-diagnosed-Weight Gain', 'Obesity-followed-Hypothalamic Diseases', 'Wounds and Injuries-predict-Nervous System Diseases', 'Nervous System Diseases-comprise-Seizures', 'Nervous System Diseases-compare-Seizures', 'Diabetes Mellitus-assess-Hyperglycemia', 'Carcinoma, Hepatocellular-occur-Venous Thrombosis', 'Neoplasms-occur-Venous Thrombosis', 'Death-prolong-Musculoskeletal Pain', 'Cardiovascular Diseases-attenuated-Cystic Fibrosis', 'Drug-Related Side Effects and Adverse Reactions-develop-Heart Diseases', 'Diabetes Mellitus, Type 2-show-Diabetes Mellitus', 'Brain Ischemia-considered-Alzheimer Disease', 'Alzheimer Disease-established-Neurodegenerative Diseases', 'Coinfection-mitigate-Wounds and Injuries', 'Spinal Cord Injuries-result-Nervous System Diseases', 'Death-account-Hip Fractures', 'Head and Neck Neoplasms-remain-Neoplasms', 'Death-account-Fractures, Bone', 'Friedreich Ataxia-include-Diabetes Mellitus', 'Microcephaly-include-Congenital Abnormalities', 'Adenoma-include-Duodenitis', 'Death-diminish-Tauopathies', 'Alzheimer Disease-ameliorate-Neurotoxicity Syndromes', 'Dyspnea-reduce-Hodgkin Disease', 'Leukemia, Myelogenous, Chronic, BCR-ABL Positive-viewed-Chronic Disease', 'Hodgkin Disease-use-Dyspnea', 'Idiopathic Pulmonary Fibrosis-conditioned-Venous Thromboembolism', 'Pain-order-Neoplasm Metastasis', 'Idiopathic Pulmonary Fibrosis-conditioned-Hypertension, Pulmonary', 'Idiopathic Pulmonary Fibrosis-conditioned-Lung Neoplasms', 'Idiopathic Pulmonary Fibrosis-develop-Lung Neoplasms', 'Death-induce-Lung Neoplasms', 'Death-induce-Idiopathic Pulmonary Fibrosis', 'Chronic Disease-affected-Metabolic Syndrome', 'Chronic Disease-affected-Cardiovascular Diseases', 'Diabetes Mellitus, Type 2-find-Carcinoma, Hepatocellular', 'Fractures, Bone-present-Infections', 'Leukemia-remain-Hematologic Neoplasms', 'Lung Neoplasms-lead-Gastric Outlet Obstruction', 'Cystic Fibrosis-characterized-Lung Diseases', 'Shy-Drager Syndrome-characterized-Lung Diseases', 'Endocrine Gland Neoplasms-related-Neoplasms', 'Endocrine Gland Neoplasms-diagnosed-Neoplasms', 'Fetal Alcohol Spectrum Disorders-linked-Death', 'Fetal Alcohol Spectrum Disorders-get-Death', 'Neoplasms-induce-Cachexia', 'Death-registered-Neoplasms', 'Coronary Stenosis-prevent-Cardiovascular Diseases', 'Glioblastoma-receive-Neoplasms', 'Cardiovascular Abnormalities-include-Hypertrichosis', 'Cardiovascular Abnormalities-include-Abnormalities, Drug-Induced', 'Fractures, Bone-managed-Wounds and Injuries', 'Neoplasm Metastasis-result-Fractures, Bone', 'Neoplasm Metastasis-predispose-Fractures, Bone', 'Rheumatic Diseases-cause-Joint Diseases', 'Heart Failure-caused-Ischemia', 'Hemophilia A-emerge-Neoplasms', 'Cardiomyopathy, Hypertrophic-differentiate-Fabry Disease', 'Astrocytoma-known-Glioblastoma', 'Death-increase-Pancreatic Neoplasms', 'Neuronal Ceroid-Lipofuscinoses-classified-Lysosomal Storage Diseases', 'Neoplasms-offer-Pain', 'Embolism-increase-Atrial Fibrillation', 'Malaria-present-Fever', 'Infections-tend-Signs and Symptoms, Respiratory', 'Malaria-tend-Signs and Symptoms, Respiratory', 'Signs and Symptoms, Respiratory-tend-Infections', 'Sexual Dysfunction, Physiological-based-Communicable Diseases', 'Anemia-result-Hemorrhage', 'Anemia-result-Hemoglobinopathies', 'Anemia-result-Wounds and Injuries', 'Anemia-result-Heat Stress Disorders', 'Hemorrhage-shorten-Wounds and Injuries', 'Hemorrhage-shorten-Heat Stress Disorders', 'Breast Neoplasms-affect-Death', 'Erythema-associated-Mycoses', 'Mycoses-associated-Erythema', 'Erythema-associated-Ulcer', 'Ulcer-associated-Erythema', 'Pneumonia, Pneumocystis-cause-Dyspnea', 'Pneumonia, Pneumocystis-cause-Death', 'Dyspnea-cause-Death', 'Stroke-declining-Cerebral Hemorrhage', 'Stroke-account-Cerebral Hemorrhage', 'Neurodegenerative Diseases-mediate-Nerve Degeneration', 'Synovitis-associated-Arthritis, Rheumatoid', 'Arthritis, Rheumatoid-associated-Synovitis', 'Neurologic Manifestations-corroborate-Chronic Kidney Disease-Mineral and Bone Disorder', 'Cerebral Hemorrhage-approach-Stroke', 'Amyotrophic Lateral Sclerosis-provide-Drug-Related Side Effects and Adverse Reactions', 'Inflammation-associated-Synovitis', 'Synovitis-associated-Inflammation', 'Chronic Kidney Disease-Mineral and Bone Disorder-include-Aneurysm', 'Infarction-include-Aneurysm', 'Drug-Related Side Effects and Adverse Reactions-exhibit-Neurodegenerative Diseases', 'Drug-Related Side Effects and Adverse Reactions-exhibit-Amyotrophic Lateral Sclerosis', 'Diabetes Mellitus-receive-Hepatitis C', 'Hypoglycemia-document-Hypotension', 'Diabetes Mellitus-rise-Diabetic Foot', 'Hypertension-occur-von Willebrand Diseases', 'Hemorrhage-suffer-Coronary Artery Disease', 'Hypertension-suffer-Coronary Artery Disease', 'Neurodegenerative Diseases-triggered-Neuromuscular Diseases', 'Prostatitis-lead-Neoplasms', 'Melanoma-include-Neoplasm Invasiveness', 'Sarcoma, Kaposi-relate-Inflammation', 'Neoplasms-include-Sarcoma, Kaposi', 'Sarcoma, Kaposi-induced-Neoplasms', 'Sarcoma, Kaposi-include-Neoplasms', 'Acquired Immunodeficiency Syndrome-include-Neoplasms', 'Lymphoma, Primary Effusion-include-Neoplasms', 'Acquired Immunodeficiency Syndrome-include-Sarcoma, Kaposi', 'Lymphoma, Primary Effusion-include-Sarcoma, Kaposi', 'Neurotoxicity Syndromes-characterized-Seizures', 'Pleural Effusion-undergo-Pleural Diseases', 'Neurotoxicity Syndromes-characterized-Status Epilepticus', 'Neurotoxicity Syndromes-characterized-Death', 'Parkinson Disease-recapitulate-Movement Disorders', 'Diabetes Mellitus-suffer-Chronic Disease', 'Hepatolenticular Degeneration-cause-Anemia', 'Coronary Artery Disease-eliminated-Death', 'Multiple Chronic Conditions-range-Bone Marrow Failure Disorders', 'Multiple Chronic Conditions-associated-Bone Marrow Failure Disorders', 'Bone Marrow Failure Disorders-associated-Multiple Chronic Conditions', 'Neurodegenerative Diseases-point-Osteopetrosis', 'Intellectual Disability-point-Osteopetrosis', 'Acidosis, Renal Tubular-point-Osteopetrosis', 'Osteopetrosis-point-Osteomyelitis', 'Fatigue-show-Nausea', 'Fatigue-show-Dyspnea', 'Liver Diseases-underlie-Fibrosis', 'Cardiovascular Abnormalities-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-Cardiovascular Abnormalities', 'Cardiovascular Abnormalities-associated-Diabetes Mellitus, Type 2', 'Diabetes Mellitus, Type 2-associated-Cardiovascular Abnormalities', 'Diabetes Mellitus-encountered-Death', 'Aneurysm-encountered-Death', 'Neoplasms-reduce-Brain Injuries', 'Death-eplerenone-Heart Failure', 'Death-eplerenone-Myocardial Infarction', 'Hypertension, Pulmonary-identify-Death', 'Pneumothorax-defined-Hydropneumothorax', 'Cerebrovascular Disorders-occur-Immunologic Deficiency Syndromes', 'Osteoporosis-protect-Diabetes Mellitus', 'Diabetic Nephropathies-calculated-Hypertension', 'Diabetic Nephropathies-treat-Diabetes Mellitus, Type 2', 'Diabetic Nephropathies-calculated-Kidney Diseases', 'Coronary Artery Disease-assist-Shock, Cardiogenic', 'Hodgkin Disease-respond-Leukemia, Myeloid, Acute', 'Leukemia, Hairy Cell-respond-Leukemia, Myeloid, Acute', 'Endocarditis, Bacterial-dissect-Aortic Aneurysm', 'Hepatitis, Viral, Human-represent-End Stage Liver Disease', 'Hepatitis, Viral, Human-represent-Chemical and Drug Induced Liver Injury', 'Neoplasms-characterized-Pain', 'Neoplasm Metastasis-characterized-Pain', 'Pain-originate-Spasm', 'Prostatic Neoplasms-identify-Communicable Diseases', 'Pain-overlap-Sensation Disorders', 'Neoplasms-compared-Esophageal Achalasia', 'Dwarfism, Pituitary-suffer-Cardiovascular Abnormalities', 'Acromegaly-characterized-Cardiomyopathies', 'Acromegaly-result-Cardiomyopathies', 'Lupus Erythematosus, Systemic-emerging-Atherosclerosis', 'Cardiomyopathies-characterized-Fibrosis', 'Cardiomyopathies-characterized-Necrosis', 'Cardiomyopathies-characterized-Hypertrophy', 'Liver Diseases-reduce-Fibrosis', 'Neoplasms-eliminate-Death', 'Cholelithiasis-lead-Death', 'Hepatitis B-progress-Carcinoma, Hepatocellular', 'Arterial Occlusive Diseases-occur-Thrombosis', 'Breast Neoplasms-include-Death', 'Pleural Effusion-caused-Breast Neoplasms', 'Neoplasms-correlated-Pleural Effusion', 'Pleural Effusion-correlated-Neoplasms', 'Parasitic Diseases-include-Infections', 'Breast Neoplasms-compare-Lung Neoplasms', 'Aneuploidy-produce-Neoplasms', 'Cardiovascular Diseases-account-Neoplasms', 'Ventricular Fibrillation-underlie-Abnormalities, Drug-Induced', 'Ventricular Fibrillation-underlie-Syncope', 'Hemoglobinopathies-recognized-Hyperuricemia', 'Endometriosis-cause-Inflammation', 'Endometriosis-cause-Pain', 'Endometriosis-cause-Infertility, Female', 'Endometriosis-lead-Fibrosis', 'Endometriosis-lead-Infertility, Female', 'Neoplasms-survive-Immunologic Deficiency Syndromes', 'Immunologic Deficiency Syndromes-assess-Neoplasms', 'Appendiceal Neoplasms-recommended-Neoplasm Metastasis', 'Death-suffer-Anemia', 'Ventricular Dysfunction-remain-Death', 'Pain-tolerate-Fatigue', 'AIDS-Related Complex-include-Stroke', 'AIDS-Related Complex-include-Dementia', 'AIDS-Related Complex-include-Parkinson Disease', 'AIDS-Related Complex-include-Motor Neuron Disease', 'AIDS-Related Complex-include-Cardiovascular Diseases', 'AIDS-Related Complex-include-Renal Insufficiency, Chronic', 'AIDS-Related Complex-include-End Stage Liver Disease', 'AIDS-Related Complex-include-Lung Injury', 'AIDS-Related Complex-include-Neoplasms', 'AIDS-Related Complex-include-Osteoporosis', 'AIDS-Related Complex-include-Diabetes Mellitus', 'Motor Neuron Disease-group-Cardiovascular Diseases', 'Motor Neuron Disease-group-Renal Insufficiency, Chronic', 'Motor Neuron Disease-group-End Stage Liver Disease', 'Liver Diseases-reported-Non-alcoholic Fatty Liver Disease', 'Liver Diseases-reported-Metabolic Syndrome', 'Non-alcoholic Fatty Liver Disease-reported-Metabolic Syndrome', 'Myoclonic Epilepsies, Progressive-experience-Pain', 'Death, Sudden-derive-Heart Diseases', 'Death, Sudden-prevent-Cardiomyopathy, Hypertrophic', 'Heart Diseases-prevent-Cardiomyopathy, Hypertrophic', 'Hyperglycemia-associated-Diabetic Angiopathies', 'Diabetic Angiopathies-associated-Hyperglycemia', 'Hypoglycemia-associated-Diabetic Angiopathies', 'Diabetic Angiopathies-associated-Hypoglycemia', 'Neoplasms-extend-Carcinoma, Squamous Cell', 'Diabetes Mellitus-consist-Death', 'Diabetes Mellitus-represent-Chronic Disease', 'Metabolic Syndrome-represent-Chronic Disease', 'Drug-Related Side Effects and Adverse Reactions-cause-Neurotoxicity Syndromes', 'Lung Neoplasms-recognized-Death', 'Leukemia-account-Neoplasms', 'Brain Neoplasms-account-Neoplasms', 'Lymphoma-account-Neoplasms', 'Memory Disorders-associated-Brain Injuries', 'Brain Injuries-associated-Memory Disorders', 'Epilepsy, Temporal Lobe-associated-Brain Injuries', 'Brain Injuries-associated-Epilepsy, Temporal Lobe', 'Seizures-affect-Sclerosis', 'Nervous System Diseases-associated-Brain Injuries', 'Brain Injuries-associated-Nervous System Diseases', 'Seizures-affect-Epilepsy, Temporal Lobe', 'Sclerosis-affect-Epilepsy, Temporal Lobe', 'Glioma-play-Glioblastoma', 'Anemia-include-Substance-Related Disorders', 'Malaria-followed-HIV Infections', 'Malaria-followed-Acquired Immunodeficiency Syndrome', 'Aortic Valve Stenosis-represent-Heart Valve Diseases', 'Polyploidy-develop-Carcinoma, Hepatocellular', 'Anemia, Sickle Cell-cause-Death', 'Anemia, Sickle Cell-continue-Death', 'Anemia, Sickle Cell-extend-Pain', 'Death-include-Cholecystitis, Acute', 'Death-determined-End Stage Liver Disease', 'Sleep Initiation and Maintenance Disorders-experienced-Cardiovascular Diseases', 'Hypertension-carry-Cardiomyopathy, Hypertrophic', 'Hypertension-carry-Stroke', 'Stomach Neoplasms-associated-Death', 'Death-associated-Stomach Neoplasms', 'Psychomotor Agitation-identified-Colorectal Neoplasms', 'Psychomotor Agitation-noted-Edema', 'Psychomotor Agitation-identified-Head and Neck Neoplasms', 'Fibrosis-decrease-Infections', 'Death-stoodat-Stroke', 'Myocardial Infarction-stoodat-Stroke', 'Iatrogenic Disease-cause-Diabetes Mellitus', 'Abnormalities, Drug-Induced-characterized-Intellectual Disability', 'Abnormalities, Drug-Induced-result-Intellectual Disability', 'Chagas Disease-infected-Chronic Disease', 'Chagas Disease-prevent-Infections', 'HIV Infections-stemm-Cardiovascular Diseases', 'Cardiovascular Diseases-shared-Mastocytosis, Systemic', 'Cardiovascular Diseases-optimized-Mastocytosis, Systemic', 'Arthritis, Rheumatoid-include-Mastocytosis, Systemic', 'Lysosomal Storage Diseases-correct-Genetic Diseases, Inborn', 'Thyroid Cancer, Papillary-extracted-Neoplasms', 'Nerve Degeneration-lead-Paralysis', 'Ossification of Posterior Longitudinal Ligament-correlate-Cardiomyopathies', 'Seizures-induced-Fever', 'Xanthomatosis-associated-Hyperlipoproteinemia Type II', 'Hyperlipoproteinemia Type II-associated-Xanthomatosis', 'Xanthomatosis-include-Xanthomatosis, Cerebrotendinous', 'Hyperlipoproteinemia Type II-include-Xanthomatosis, Cerebrotendinous', 'Sleep Wake Disorders-include-Head and Neck Neoplasms', 'Hearing Loss-include-Head and Neck Neoplasms', 'Sleep Wake Disorders-associated-Musculoskeletal Diseases', 'Musculoskeletal Diseases-associated-Sleep Wake Disorders', 'Hemophilia A-expect-Hemorrhage', 'Inflammation-cooperate-Neoplasms', 'Pulmonary Fibrosis-result-Respiratory Insufficiency', 'Death-calculate-Neoplasms', 'Anemia, Sickle Cell-lie-Death', 'Anemia, Sickle Cell-protected-Death', 'Anemia, Sickle Cell-lie-Malaria', 'Anemia, Sickle Cell-protected-Malaria', 'Mastocytosis, Systemic-characterised-Anemia', 'Sepsis-lead-Anemia, Sickle Cell', 'Mastocytosis, Systemic-characterised-Infarction', 'Mastocytosis, Systemic-characterised-Chronic Disease', 'Death-exceed-Lymphoma, T-Cell', 'Appendicitis-test-Death', 'Neoplasms-make-Infections', 'Nervous System Diseases-affect-Ischemia', 'Nervous System Diseases-affect-Diabetes Mellitus', 'Diabetes Mellitus-prevent-Diabetic Neuropathies', 'Death-show-Osteochondrodysplasias', 'Neoplasms-appealing-Pain', 'Hereditary Breast and Ovarian Cancer Syndrome-include-Tuberculosis, Meningeal', 'Hereditary Breast and Ovarian Cancer Syndrome-include-Cerebral Hemorrhage', 'Hereditary Breast and Ovarian Cancer Syndrome-include-Meningitis, Cryptococcal', 'Hereditary Breast and Ovarian Cancer Syndrome-include-Encephalitis', 'Hereditary Breast and Ovarian Cancer Syndrome-include-Leukoencephalopathy, Progressive Multifocal', 'Hereditary Breast and Ovarian Cancer Syndrome-include-Central Nervous System Diseases', 'Hereditary Breast and Ovarian Cancer Syndrome-include-Stroke', 'Hereditary Breast and Ovarian Cancer Syndrome-include-Polyneuropathies', 'Infections-induce-Sepsis', 'Death-noted-Infections', 'Spinal Cord Injuries-decrease-Pneumonia', 'Xeroderma Pigmentosum-characterised-Fibrous Dysplasia of Bone', 'Genetic Diseases, Inborn-characterised-Fibrous Dysplasia of Bone', 'Death-show-Heart Diseases', 'Death-show-Cardiomyopathies', 'Heart Diseases-represent-Cardiomyopathies', 'Spinal Cord Diseases-occur-Neoplasms', 'Spinal Cord Diseases-occur-Neoplasm Metastasis', 'Sensation Disorders-continue-Neuralgia', 'Colorectal Neoplasms-experience-Pain', 'Neoplasm Metastasis-experience-Pain', 'Hemolysis-increased-Pulmonary Arterial Hypertension', 'Inflammation-manifest-Polymyalgia Rheumatica', 'Arterial Occlusive Diseases-manifest-Polymyalgia Rheumatica', 'Arteritis-cause-Vision Disorders', 'Arteritis-cause-Stroke', 'Arteritis-cause-Aneurysm', 'Basal Ganglia Cerebrovascular Disease-cause-Vision Disorders', 'Anemia, Sickle Cell-linked-Infections', 'Basal Ganglia Cerebrovascular Disease-cause-Stroke', 'Basal Ganglia Cerebrovascular Disease-cause-Aneurysm', 'Polymyalgia Rheumatica-manifest-Pain', 'Polymyalgia Rheumatica-manifest-Pelvic Girdle Pain', 'Polymyalgia Rheumatica-identified-Bursitis', 'Phenylketonurias-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-Phenylketonurias', 'Neoplasms-occupy-Abnormalities, Drug-Induced', 'Death-include-Graft vs Host Disease', 'Tuberculosis, Osteoarticular-occupy-Abnormalities, Drug-Induced', 'Neoplasms-undergo-Death', 'Death-remain-Lymphoma', 'Aortic Coarctation-reduced-Hypertension', 'Aortic Coarctation-reduced-Atherosclerosis', 'Leukemia, Mast-Cell-derived-Mastocytosis, Systemic', 'Neurodegenerative Diseases-study-Drug-Related Side Effects and Adverse Reactions', 'Myocardial Infarction-studied-Ventricular Dysfunction', 'Parkinson Disease-display-Basal Ganglia Diseases', 'Myocardial Infarction-studied-Motion Sickness', 'Parkinson Disease-involve-Neurodegenerative Diseases', 'Basal Ganglia Diseases-involve-Neurodegenerative Diseases', 'Communicable Diseases-include-Pulmonary Arterial Hypertension', 'Arthritis, Rheumatoid-reduce-Cardiovascular Diseases', 'Neoplasms-combined-Hemorrhage', 'Diabetes Mellitus-prevent-Myocardial Infarction', 'Diabetes Mellitus-prevent-Stroke', 'Death-elevated-Mastocytosis, Systemic', 'Death-elevated-Neoplasms', 'Death-elevated-Respiratory System Abnormalities', 'Diabetes Mellitus-prevent-Cardiovascular Diseases', 'Mesothelioma-represent-Neoplasms', 'Ciliopathies-characterized-Kidney Diseases, Cystic', 'Ciliopathies-characterized-Liver Cirrhosis', 'Spinal Cord Diseases-include-Nervous System Diseases', 'Inflammation-develop-Bone Diseases, Metabolic', 'Arthritis, Rheumatoid-require-Infections', 'Arthritis, Rheumatoid-require-Rheumatic Diseases', 'Arthritis, Rheumatoid-require-Osteoporosis', 'Arthritis, Rheumatoid-require-Neoplasms', 'Neoplasms-accept-Death', 'Muscular Atrophy-associated-Muscular Atrophy, Spinal', 'Muscular Atrophy, Spinal-associated-Muscular Atrophy', 'Stroke-estimated-Hypertrophy, Left Ventricular', 'Cardiovascular Diseases-describe-Cardiovascular Abnormalities', 'Renal Insufficiency, Chronic-need-Kidney Diseases', 'Paraneoplastic Syndromes-produced-Neoplasms', 'Paraneoplastic Syndromes-related-Neoplasms', 'Paraneoplastic Syndromes-categorized-Tuberculosis, Osteoarticular', 'Neoplasms-categorized-Tuberculosis, Osteoarticular', 'Paraneoplastic Syndromes-differentiate-Neoplasms', 'Parasomnias-include-Sleep Wake Disorders', 'Narcolepsy-include-Sleep Wake Disorders', 'Venous Thrombosis-documented-Obesity, Abdominal', 'HIV Infections-develop-Peritoneal Neoplasms', 'Peritoneal Neoplasms-associated-Death', 'Death-associated-Peritoneal Neoplasms', 'Cystic Fibrosis-improve-Death', 'Diabetes Mellitus-include-Cystic Fibrosis', 'Glucose Intolerance-affect-Cystic Fibrosis', 'Diabetes Mellitus-affect-Cystic Fibrosis', 'Diabetes Mellitus-differ-Diabetes Mellitus, Type 2', 'Cystic Fibrosis-affect-Diabetes Mellitus, Type 2', 'Pulmonary Disease, Chronic Obstructive-increase-Aortic Aneurysm, Abdominal', 'Aneurysm-treated-Rupture', 'Pulmonary Disease, Chronic Obstructive-increase-Rupture', 'Hypertension-associated-Fetal Growth Retardation', 'Fetal Growth Retardation-associated-Hypertension', 'Kidney Diseases-established-Death', 'Neoplasms-operated-Osteoarthritis', 'Infections-linked-Neutropenia', 'Infections-needed-Myelodysplastic Syndromes', 'Infections-linked-Leukemia, Myeloid, Acute', 'Neutropenia-evolve-Myelodysplastic Syndromes', 'Kidney Diseases-aggravate-Cardiovascular Diseases', 'Spinal Injuries-become-Paralysis', 'Muscular Atrophy, Spinal-restore-Death', 'Immunologic Deficiency Syndromes-reported-Drug-Related Side Effects and Adverse Reactions', 'Diabetes Mellitus-reduce-Glucose Intolerance', 'Glucose Intolerance-reduce-Diabetes Mellitus', 'Acromegaly-result-Death', 'Shock, Cardiogenic-develop-Infarction', 'Sleep Wake Disorders-examine-Sleep Initiation and Maintenance Disorders', 'Sleep Wake Disorders-examine-Disorders of Excessive Somnolence', 'Prader-Willi Syndrome-estimated-Death', 'Leukemia, Myelogenous, Chronic, BCR-ABL Positive-demonstrate-Drug-Related Side Effects and Adverse Reactions', 'Aortic Aneurysm-make-Death', 'Dermatofibrosarcoma-relapse-Kidney Diseases', 'Dermatofibrosarcoma-relapse-Bone Marrow Diseases', 'Carcinoma, Squamous Cell-included-Acquired Immunodeficiency Syndrome', 'Anus Neoplasms-obtain-Drug-Related Side Effects and Adverse Reactions', 'Atrophy-cause-Parkinson Disease, Secondary', 'Neurodegenerative Diseases-cause-Parkinson Disease, Secondary', 'Parkinson Disease-produce-Brain Stem Neoplasms', 'Neoplasm Metastasis-achieve-Liver Failure', 'Carcinoma-compare-End Stage Liver Disease', 'Trochlear Nerve Diseases-indicated-Neoplasm Metastasis', 'Neoplasms-indicated-Neoplasm Metastasis', 'Amyloidosis-obtain-Death', 'Amyloidosis-complicate-Arthritis, Rheumatoid', 'Melanoma-cause-Death', 'Death-investigate-Huntington Disease', 'Holoprosencephaly-develop-Epilepsy', 'Primary Myelofibrosis-accompanied-Fibrosis', 'Ovarian Neoplasms-aimed-Neoplasms', 'Infections-seen-Hepatitis C', 'Hepatitis C, Chronic-present-Liver Failure', 'Brain Diseases-Decompensated-Liver Diseases', 'Ascites-Decompensated-Liver Diseases', 'Jaundice-Decompensated-Liver Diseases', 'Gastrointestinal Hemorrhage-Decompensated-Liver Diseases', 'Hepatorenal Syndrome-Decompensated-Liver Diseases', 'Carcinogenesis-increase-Death', 'Aneuploidy-show-Intellectual Disability', 'Multiple Sclerosis-evolve-Nervous System Diseases', 'Intellectual Disability-display-Growth Disorders', 'Intellectual Disability-display-Craniofacial Abnormalities', 'Intellectual Disability-display-Nervous System Diseases', 'Growth Disorders-display-Craniofacial Abnormalities', 'Growth Disorders-display-Nervous System Diseases', 'Fractures, Bone-underestimated-Osteoporosis', 'Mesothelioma-followed-Neoplasms', 'Osteosarcoma-followed-Neoplasms', 'Leukemia, Myeloid, Acute-occur-Hodgkin Disease', 'Leukemia, Myeloid, Acute-occur-Lymphoma, Non-Hodgkin', 'Leukemia, Myeloid, Acute-occur-Multiple Myeloma', 'Leukemia, Myeloid, Acute-occur-Polycythemia Vera', 'Leukemia, Myeloid, Acute-occur-Thyroid Neoplasms', 'Leukemia, Myeloid, Acute-occur-Breast Neoplasms', 'Neoplasms-include-Sarcoma', 'Fistula-occur-Diabetes Mellitus', 'Fistula-influenced-Diabetes Mellitus', 'Carcinoma, Basal Cell-exhibit-Substance-Related Disorders', 'Genetic Diseases, X-Linked-cause-Intellectual Disability', 'Fistula-influenced-Hypotension', 'Diabetes Mellitus-influenced-Hypotension', 'Spinal Cord Neoplasms-maintain-Pain', 'Short Bowel Syndrome-relieve-Nausea', 'Death-observed-Neurologic Manifestations', 'Short Bowel Syndrome-relieve-Vomiting', 'Neurologic Manifestations-succumb-Neoplasms', 'Neoplasms-contain-Ulcer', 'Ulcer-found-Neoplasms', 'Cleft Lip-suffice-Intellectual Disability', 'Holoprosencephaly-encompass-Neural Tube Defects', 'Neoplasms-need-Chordoma', 'AIDS Arteritis, Central Nervous System-persist-Infections', 'Hand Injuries-persist-Infections', 'Death-influence-Renal Insufficiency, Chronic', 'Death-influence-Chronic Kidney Disease-Mineral and Bone Disorder', 'Sepsis-reported-Encephalitis', 'Glioma-implanted-Immunologic Deficiency Syndromes', 'Stroke-categorized-Ischemia', 'Polycystic Ovary Syndrome-linked-Dyslipidemias', 'Pain-explain-Brain Injuries, Traumatic', 'Basal Ganglia Cerebrovascular Disease-lead-Ischemia', 'Basal Ganglia Cerebrovascular Disease-lead-Stroke', 'Diabetic Cardiomyopathies-recognized-Coronary Artery Disease', 'Basal Ganglia Cerebrovascular Disease-lead-Aneurysm', 'Basal Ganglia Cerebrovascular Disease-lead-Sinus Thrombosis, Intracranial', 'Diabetic Cardiomyopathies-recognized-Disease', 'Basal Ganglia Cerebrovascular Disease-lead-Giant Cell Arteritis', 'Diabetic Cardiomyopathies-lead-Cardiomyopathy, Hypertrophic', 'Basal Ganglia Cerebrovascular Disease-lead-Aortitis', 'Cardiomyopathies-recognized-Coronary Artery Disease', 'Cardiomyopathies-recognized-Disease', 'Cardiomyopathies-lead-Cardiomyopathy, Hypertrophic', 'Hypertension-recognized-Disease', 'Hypertension-recognized-Cardiomyopathy, Hypertrophic', 'Hypertension-lead-Cardiomyopathy, Hypertrophic', 'Coronary Artery Disease-recognized-Disease', 'Coronary Artery Disease-recognized-Cardiomyopathy, Hypertrophic', 'Coronary Artery Disease-lead-Cardiomyopathy, Hypertrophic', 'Disease-lead-Cardiomyopathy, Hypertrophic', 'Prostatic Neoplasms-caused-Prostatic Hyperplasia', 'Neoplasms-caused-Prostatic Hyperplasia', 'Myeloproliferative Disorders-associated-Splenomegaly', 'Splenomegaly-associated-Myeloproliferative Disorders', 'Myeloproliferative Disorders-associated-Hematologic Diseases', 'Hematologic Diseases-associated-Myeloproliferative Disorders', 'Chemical and Drug Induced Liver Injury-associated-Tuberculosis', 'Tuberculosis-associated-Chemical and Drug Induced Liver Injury', 'Chronic Disease-manage-Diabetes Mellitus', 'Death-linked-Epilepsy', 'Death-linked-Urinary Incontinence', 'Death-linked-Vision Disorders', 'Death-linked-Cerebral Palsy', 'Dementia-develop-Infections', 'Pain-assess-Death', 'Hip Dislocation-suffer-Wounds and Injuries', 'Mucopolysaccharidosis III-observed-Death', 'Death-shown-Headache Disorders, Secondary', 'Death-shown-Vision Disorders', 'Death-shown-Neoplasms', 'Thyroid Neoplasms-comprise-Thyroid Cancer, Papillary', 'Neoplasms-characterize-Thecoma', 'Fistula-abandoned-Thrombosis', 'Fistula-follow-Infections', 'Metabolic Syndrome-live-Chronic Disease', 'Gastritis-prevent-Stomach Neoplasms', 'Obesity-compare-Prader-Willi Syndrome', 'Peripheral Arterial Disease-stratified-HIV Infections', 'Peripheral Arterial Disease-undergo-HIV Infections', 'Sphingolipidoses-pick-Niemann-Pick Disease, Type C', 'Pancreatitis, Chronic-lead-Inflammation', 'Hereditary Breast and Ovarian Cancer Syndrome-lead-Inflammation', 'Pancreatitis-re-evaluate-Malnutrition', 'Pancreatitis-re-evaluate-Exocrine Pancreatic Insufficiency', 'Pancreatitis-re-evaluate-Diabetes Mellitus', 'Pancreatitis-require-Pain', 'Colorectal Neoplasms-undergo-Venous Thromboembolism', 'Neoplasms-undergo-Venous Thromboembolism', 'Pain-associated-Dyskinesia, Drug-Induced', 'Dyskinesia, Drug-Induced-associated-Pain', 'Venous Thromboembolism-increase-Neoplasms', 'Jaw Diseases-associated-Dyskinesia, Drug-Induced', 'Dyskinesia, Drug-Induced-associated-Jaw Diseases', 'Pain-occur-Dyskinesia, Drug-Induced', 'Pain-occur-Muscle Spasticity', 'Pain-include-Jaw Diseases', 'Pain-include-Dyskinesia, Drug-Induced', 'Takotsubo Cardiomyopathy-associated-Acute Kidney Injury', 'Acute Kidney Injury-associated-Takotsubo Cardiomyopathy', 'Takotsubo Cardiomyopathy-associated-Postoperative Complications', 'Postoperative Complications-associated-Takotsubo Cardiomyopathy', 'Inflammation-induced-Osteolysis', 'Inflammation-prevent-Osteolysis', 'Gilbert Disease-inspect-Hyperbilirubinemia', 'Osteolysis-induced-Neoplasms', 'Breast Neoplasms-used-Osteolysis', 'Infections-observed-Cerebrospinal Fluid Otorrhea', 'Hypothyroidism-maintain-Euthyroid Sick Syndromes', 'Epilepsy-associated-Deafness', 'Deafness-associated-Epilepsy', 'Epilepsy-associated-Peripheral Nervous System Diseases', 'Peripheral Nervous System Diseases-associated-Epilepsy', 'Death-discuss-Hip Fractures', 'Death-given-Dementia', 'Aortic Aneurysm, Abdominal-followed-Neoplasms', 'Hallucinations-show-Vision Disorders', 'Death-mask-Dementia', 'Carcinoma, Pancreatic Ductal-carry-Neoplasms', 'Pancreatic Neoplasms-carry-Neoplasms', 'Pancreatic Neoplasms-identify-Neoplasms', 'Death-become-Carcinoma, Pancreatic Ductal', 'Death-projected-Carcinoma, Pancreatic Ductal', 'Carcinoma, Pancreatic Ductal-become-Neoplasms', 'Death-hypothesize-Kidney Diseases', 'Death-hypothesize-Communicable Diseases', 'Amyloidosis-related-Death', 'Renal Insufficiency, Chronic-related-Mastocytosis, Systemic', 'Renal Insufficiency, Chronic-induce-Mastocytosis, Systemic', 'Death-hypothesize-Subarachnoid Hemorrhage', 'Renal Insufficiency, Chronic-reduce-Hemolytic-Uremic Syndrome', 'Mastocytosis, Systemic-induce-Hemolytic-Uremic Syndrome', 'Coinfection-elevate-Inflammation', 'Subarachnoid Hemorrhage-increase-Death', 'Neoplasms-related-Sensation Disorders', 'HIV Infections-evaluate-Tuberculosis', 'Dermatitis, Exfoliative-persist-Ulcer', 'Death-suffer-Chemical and Drug Induced Liver Injury', 'Carcinoma, Non-Small-Cell Lung-forecast-Death', 'Death-gain-Carcinoma, Non-Small-Cell Lung', 'Meningeal Neoplasms-used-Neoplasms', 'Lymphoma-protect-Drug-Related Side Effects and Adverse Reactions', 'Meningeal Neoplasms-pose-Neoplasms', 'Meningeal Neoplasms-leave-Neoplasms', 'Death-cause-Shock', 'Infarction, Middle Cerebral Artery-identify-Stroke', 'Carcinoma, Hepatocellular-classify-Neoplasms', 'Hypertension-transferred-Huntington Disease', 'Metabolic Syndrome-associated-Infections', 'Infections-associated-Metabolic Syndrome', 'Bone Diseases-associated-Infections', 'Infections-associated-Bone Diseases', 'Amyloidosis-proven-Liver Failure', 'Amyloidosis-classified-Nervous System Diseases', 'Adenocarcinoma-represent-Neoplasms', 'Parkinson Disease-identify-Neuralgia', 'Hypertension-observed-Pachyonychia Congenita', 'Anemia, Sickle Cell-typified-Anemia, Hemolytic', 'Drug Hypersensitivity-increasing-Neoplasms', 'Anemia, Sickle Cell-remain-Infections', 'Death-diagnosed-Brain Neoplasms', 'Cystic Fibrosis-lead-Infections', 'Cystic Fibrosis-lead-Inflammation', 'Cystic Fibrosis-include-Inflammation', 'Cystic Fibrosis-regulate-Inflammation', 'Pleural Diseases-employed-Pleural Effusion, Malignant', 'Anemia-require-Myelodysplastic Syndromes', 'Pleural Effusion, Malignant-herald-Neoplasms', 'Diabetes Mellitus, Type 1-develop-Renal Insufficiency', 'Death-attenuate-Obesity', 'Pediatric Obesity-attenuate-Obesity', 'Dermatofibrosarcoma-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-Dermatofibrosarcoma', 'Acromegaly-stratified-Dermatofibrosarcoma', 'Hypertension-expanding-Renal Insufficiency, Chronic', 'Dermatofibrosarcoma-correlated-Cardiovascular Diseases', 'Carcinoma, Non-Small-Cell Lung-focused-Neoplasms', 'Dental Leakage-associated-Death', 'Death-associated-Dental Leakage', 'Hyperpigmentation-observed-Nausea', 'Hyperpigmentation-observed-Vomiting', 'Hyperpigmentation-noted-Weight Loss', 'Clubfoot-include-Abnormalities, Drug-Induced', 'Nausea-noted-Weight Loss', 'Hypospadias-include-Abnormalities, Drug-Induced', 'Vomiting-noted-Weight Loss', 'Hydrocephalus-include-Abnormalities, Drug-Induced', 'Cleft Lip-include-Abnormalities, Drug-Induced', 'Bladder Exstrophy-include-Abnormalities, Drug-Induced', 'Muscular Dystrophy, Duchenne-characterized-Muscle Weakness', 'Cystic Fibrosis-include-Infections', 'Cystic Fibrosis-repeat-Infections', 'Cystic Fibrosis-repeat-Lung Diseases', 'Infections-repeat-Lung Diseases', 'Cholecystitis, Acute-present-Death', 'Obesity-protect-Pulmonary Disease, Chronic Obstructive', 'Asthma-feature-Death', 'Neoplasms-reinforce-Heart Arrest', 'Neurologic Manifestations-initiate-Neoplasms', 'Obesity-enable-Weight Loss', 'Hyperlipidemias-develop-Alzheimer Disease', 'Pancreatitis-known-Diabetes Mellitus', 'Diabetes Mellitus-related-Pancreatitis', 'Glucose Metabolism Disorders-known-Diabetes Mellitus', 'Hypertension-include-Cardiac Complexes, Premature', 'Diabetes Mellitus-include-Cardiac Complexes, Premature', 'Coronary Artery Disease-restricted-Myocardial Infarction', 'Dyslipidemias-include-Cardiac Complexes, Premature', 'Cardiovascular Diseases-include-Cardiac Complexes, Premature', 'Osteoarthritis-include-Cardiac Complexes, Premature', 'Sleep Apnea, Obstructive-include-Cardiac Complexes, Premature', 'Neoplasms-include-Cardiac Complexes, Premature', 'Liver Diseases, Alcoholic-take-Chronic Disease', 'Liver Diseases, Alcoholic-take-Fatty Liver', 'Liver Diseases, Alcoholic-take-Chemical and Drug Induced Liver Injury', 'Liver Diseases, Alcoholic-take-Fibrosis', 'Fatty Liver-mean-Liver Cirrhosis', 'Chronic Disease-mean-Liver Cirrhosis', 'Liver Diseases, Alcoholic-take-Hepatitis, Alcoholic', 'Nervous System Diseases-address-Korsakoff Syndrome', 'Anemia, Macrocytic-associated-Anemia', 'Anemia-associated-Anemia, Macrocytic', 'Amnesia-occur-Polyneuropathies', 'Delirium-occur-Polyneuropathies', 'Anemia-result-Communicable Diseases', 'Ischemia-elevate-Hypertrophy', 'Growth Disorders-produce-Neoplasms', 'Rheumatoid Vasculitis-associated-HIV Seropositivity', 'HIV Seropositivity-associated-Rheumatoid Vasculitis', 'Glomerulonephritis-develop-Proteinuria', 'Sarcoma-regarded-Neoplasms', 'Prostatic Neoplasms-induce-Neoplasms', 'Anemia-result-Multiple Organ Failure', 'Acute Pain-associated-Neuralgia', 'Neuralgia-associated-Acute Pain', 'Spinal Cord Injuries-explain-Death', 'Diabetes Mellitus-predispose-Cardiovascular Abnormalities', 'End Stage Liver Disease-appear-Death', 'Hyperlipidemias-linked-Cardiovascular Diseases', 'Kidney Failure, Chronic-prevent-Death', 'Death-prevent-Hyperkalemia', 'Death-prevent-Uremia', 'Respiratory Distress Syndrome-complicated-Bronchopulmonary Dysplasia', 'Neoplasms-represent-Hemorrhoids', 'Aortic Aneurysm, Abdominal-influence-Rupture', 'Aortic Aneurysm, Abdominal-influence-Death', 'Coronary Artery Disease-contribute-Cardiovascular Diseases', 'Neoplasms-account-Lung Neoplasms', 'Neoplasms-contribute-Lung Diseases', 'Neoplasms-contribute-Pneumonia', 'Neoplasms-account-HIV Infections', 'Lung Neoplasms-account-HIV Infections', 'Lung Diseases-account-HIV Infections', 'Pneumonia-account-HIV Infections', 'Neoplasms-cause-Brain Neoplasms', 'Cardiovascular Diseases-contribute-Hypertension', 'Cardiovascular Diseases-contribute-Coronary Artery Disease', 'Cardiovascular Diseases-contribute-Stroke', 'Cardiovascular Diseases-contribute-Neoplasms', 'Cardiovascular Diseases-accounted-Wounds and Injuries', 'Cardiovascular Diseases-accounted-Diabetes Mellitus', 'Heart Failure-experience-Fatigue', 'Heart Failure-experience-Cerebrovascular Disorders', 'Heart Failure-relate-Hypotension', 'Fatigue-relate-Hypotension', 'Cerebrovascular Disorders-relate-Hypotension', 'Hypertension-emphasize-Heart Failure', 'Ascites-confirm-Neoplasms', 'Acquired Immunodeficiency Syndrome-increasing-HIV Infections', 'Death-increasing-HIV Infections', 'Death-cause-Malaria', 'Death-incorporate-Infections', 'Neoplasms-suffer-Glioblastoma', 'Death-increased-Metabolic Diseases', 'Neoplasms-increased-Metabolic Diseases', 'Cardiovascular Diseases-increase-Metabolic Diseases', 'Neoplasms-prevent-Cachexia', 'Death-prevent-Cachexia', 'Dyspnea-lead-Atrial Fibrillation', 'Cough-lead-Atrial Fibrillation', 'Hemochromatosis-cause-Death', 'Neoplasm Metastasis-lead-Carcinoma, Hepatocellular', 'Sepsis-follow-Pneumonia', 'Death-remain-Spinal Cord Injuries', 'Respiratory Insufficiency-caused-Pulmonary Fibrosis', 'Respiratory Insufficiency-caused-Lung Neoplasms', 'Lupus Erythematosus, Systemic-emerge-Cardiovascular Diseases', 'Vasculitis-presume-Granulomatosis with Polyangiitis', 'Glomerulonephritis-affect-Kidney Diseases', 'Hyperplasia-control-Leukemia, Myeloid', 'Intracranial Aneurysm-remain-Death', 'Death-experience-Aneurysm', 'Retinal Diseases-suffered-Diabetes Mellitus', 'Edema-ascribed-Wounds and Injuries', 'Pain-ascribed-Wounds and Injuries', 'Open Bite-caused-Infections', 'Open Bite-caused-Aneurysm', 'Open Bite-caused-Gangrene', 'Death-contribute-Neoplasms', 'Death-include-Metabolic Diseases', 'Death-show-Lung Neoplasms', 'Neoplasms-considered-Airway Obstruction', 'Thalassemia-lead-Carcinogenesis', 'Squamous Intraepithelial Lesions-precede-Neoplasms', 'Diabetes Mellitus-correlated-Death', 'Diabetes Mellitus-correlated-Kidney Diseases', 'Neoplasms-potentiate-Drug-Related Side Effects and Adverse Reactions', 'Bone Neoplasms-treated-Fractures, Bone', 'Fractures, Bone-ignor-Bone Diseases', 'Deglutition Disorders-contribute-Malnutrition', 'Diabetes Mellitus-induce-Hyperglycemia', 'Atherosclerosis-induce-Hyperglycemia', 'Drug-Related Side Effects and Adverse Reactions-increase-Brain Neoplasms', 'Epilepsy-estimate-Death', 'Death-diagnosed-Epilepsy', 'Cerebral Infarction-caused-Atherosclerosis', 'Heart Diseases-used-Death', 'Heart Diseases-categorized-Death', 'Brain Injuries, Traumatic-consider-Unconsciousness', 'Multiple Myeloma-result-Kidney Diseases', 'Delirium-admitted-Stroke', 'Neoplasms-detected-Signs and Symptoms, Digestive', 'Acute Kidney Injury-exposed-Inflammation', 'Acute Kidney Injury-exposed-Reperfusion Injury', 'Muscular Dystrophy, Duchenne-characterized-Muscular Atrophy', 'Genetic Diseases, X-Linked-characterized-Muscular Atrophy', 'Signs and Symptoms, Respiratory-occur-Lung Diseases', 'Diabetes Mellitus, Type 2-associated-Inflammation', 'Inflammation-associated-Diabetes Mellitus, Type 2', 'Non-alcoholic Fatty Liver Disease-associated-Inflammation', 'Inflammation-associated-Non-alcoholic Fatty Liver Disease', 'Hyperlipidemias-associated-Inflammation', 'Inflammation-associated-Hyperlipidemias', 'Hypertension-lived-Cardiovascular Diseases', 'Hypertension-experience-Cardiovascular Diseases', 'Opioid-Related Disorders-experience-Pain', 'Obesity-listed-Hypogonadism', 'Anemia, Sickle Cell-contribute-Cerebrovascular Disorders', 'Neoplasms-prevent-Neurologic Manifestations', 'Ureteral Obstruction-associated-Short Bowel Syndrome', 'Short Bowel Syndrome-associated-Ureteral Obstruction', 'Airway Obstruction-associated-Short Bowel Syndrome', 'Short Bowel Syndrome-associated-Airway Obstruction', 'Ureteral Obstruction-associated-Intestinal Atresia', 'Intestinal Atresia-associated-Ureteral Obstruction', 'Ureteral Obstruction-associated-Airway Obstruction', 'Airway Obstruction-associated-Ureteral Obstruction', 'Airway Obstruction-associated-Intestinal Atresia', 'Intestinal Atresia-associated-Airway Obstruction', 'Hypertension-occur-Thyroid Diseases', 'Shy-Drager Syndrome-characterised-Anemia, Hemolytic', 'Shy-Drager Syndrome-characterised-Multiple Organ Failure', 'Leukemia-apply-Polycythemia Vera', 'Aortic Aneurysm-depend-Aneurysm', 'Death, Sudden, Cardiac-prevent-Arrhythmias, Cardiac', 'HIV Infections-live-Acquired Immunodeficiency Syndrome', 'Colorectal Neoplasms-modulate-Neoplasms', 'Cardiomyopathies-provide-Death, Sudden, Cardiac', 'Cardiomyopathies-avoid-Disseminated Intravascular Coagulation', 'Channelopathies-provide-Death, Sudden, Cardiac', 'Channelopathies-avoid-Disseminated Intravascular Coagulation', 'Death, Sudden, Cardiac-avoid-Disseminated Intravascular Coagulation', 'Hypothalamic Neoplasms-distinguish-Hypothalamic Diseases', 'Neoplasms-rise-Melanoma', 'Cryptococcosis-requeir-Huntington Disease', 'Huntington Disease-demand-Kidney Diseases', 'Death-occur-Shock, Hemorrhagic', 'Death-caused-Necrosis', 'Shock, Hemorrhagic-result-Hemorrhage', 'Shock, Hemorrhagic-result-Necrosis', 'Shock, Hemorrhagic-caused-Necrosis', 'Death-move-Dysentery', 'Hemorrhage-caused-Necrosis', 'Death-take-Nutrition Disorders', 'Thalassemia-known-Anemia', 'Pain-reduce-Neoplasm Metastasis', 'Neoplasm Metastasis-reduce-Pain', 'Neoplasm Metastasis-limit-Fractures, Bone', 'Pain-limit-Fractures, Bone', 'Thyroid Neoplasms-include-Neuroendocrine Tumors', 'Sotos Syndrome-uncover-Neoplasms', 'Hypogonadism-impair-Bone Diseases', 'Neuromuscular Diseases-associated-Respiratory Insufficiency', 'Respiratory Insufficiency-associated-Neuromuscular Diseases', 'Neuromuscular Diseases-associated-Heart Failure', 'Heart Failure-associated-Neuromuscular Diseases', 'Hypogonadism-remain-Fractures, Bone', 'Diabetes Mellitus-impair-Bone Diseases', 'Leukemia, Myelogenous, Chronic, BCR-ABL Positive-sensitize-Death', 'Diabetes Mellitus-remain-Fractures, Bone', 'Hyperparathyroidism-impair-Bone Diseases', 'Hyperparathyroidism-remain-Fractures, Bone', 'Bone Diseases-remain-Fractures, Bone', 'Amyotrophic Lateral Sclerosis-lead-Muscle Weakness', 'Disease Progression-lead-Muscle Weakness', 'Polycystic Ovary Syndrome-recognized-Glucose Intolerance', 'Polycystic Ovary Syndrome-recognized-Diabetes Mellitus, Type 2', 'Polycystic Ovary Syndrome-recognized-Cardiovascular Diseases', 'Glucose Intolerance-associated-Polycystic Ovary Syndrome', 'Polycystic Ovary Syndrome-associated-Glucose Intolerance', 'Metabolic Diseases-known-Obesity', 'Hypertension, Pulmonary-tolerated-Pulmonary Arterial Hypertension', 'Papillomavirus Infections-progress-Buschke-Lowenstein Tumor', 'Polycystic Ovary Syndrome-distinguished-Hyperandrogenism', 'Muscle Weakness-ranked-Death', 'Muscle Weakness-contribute-Death', 'Spinal Cord Injuries-isolated-Wounds and Injuries', 'Cardiovascular Diseases-evaluated-Dwarfism, Pituitary', 'Peripheral Arterial Disease-exist-Critical Illness', 'Polyps-predispose-Leukodystrophy, Metachromatic', 'Polyps-predispose-Gallbladder Neoplasms', 'Death-predispose-Leukodystrophy, Metachromatic', 'Gallbladder Diseases-prevent-Death', 'Gallbladder Neoplasms-predispose-Leukodystrophy, Metachromatic', 'Leukodystrophy, Metachromatic-predispose-Gallbladder Neoplasms', 'Obesity-treat-HIV Infections', 'Arthritis, Rheumatoid-attributed-Cardiovascular Diseases', 'Anemia, Hemolytic-triggered-Glucosephosphate Dehydrogenase Deficiency', 'Kidney Diseases-range-Chemical and Drug Induced Liver Injury', 'Kidney Diseases-range-Fibrosis', 'Liver Failure-range-Chemical and Drug Induced Liver Injury', 'Chemical and Drug Induced Liver Injury-range-Fibrosis', 'Infarction, Middle Cerebral Artery-caused-Aortic Arch Syndromes', 'Infarction, Middle Cerebral Artery-caused-Dysplastic Nevus Syndrome', 'Hypertension-improve-Intermittent Claudication', 'Stomach Neoplasms-detected-Genetic Diseases, Inborn', 'Death-influence-Cystic Fibrosis', 'Cystic Fibrosis-show-Respiratory Tract Infections', 'Lymphoma-represent-HIV Infections', 'HIV Infections-develop-Lymphoma', 'Lymphoma-occur-HIV Infections', 'Digestive System Neoplasms-lead-Death', 'Low Back Pain-include-Musculoskeletal Diseases', 'Neck Pain-include-Musculoskeletal Diseases', 'Diabetes Mellitus-include-Musculoskeletal Diseases', 'Fibrosis-include-Musculoskeletal Diseases', 'Respiratory Tract Infections-contribute-Coronary Artery Disease', 'Edema-include-Death', 'Epilepsy-pose-Seizures', 'Critical Illness-identify-Graft Occlusion, Vascular', 'Lymphoma-exhibit-Aneuploidy', 'Death-affected-Spinal Cord Injuries', 'Cardiovascular Diseases-reduce-Spinal Cord Injuries', 'Infections-reduce-Spinal Cord Injuries', 'Diarrhea-observed-Asthma', 'Hepatitis C-remain-Chemical and Drug Induced Liver Injury', 'Hepatitis C-remain-Kidney Diseases', 'Hepatitis C-treat-Renal Insufficiency, Chronic', 'Infections-contribute-Cardiovascular Diseases', 'Glioblastoma-summarize-Meningeal Neoplasms', 'Osteoporosis-affected-Neurodegenerative Diseases', 'Sleep Wake Disorders-include-Dyskinesia, Drug-Induced', 'Sleep Wake Disorders-include-Metabolic Syndrome', 'Myositis-considered-Muscular Diseases', 'Myositis-lead-Muscle Weakness', 'Drug-Related Side Effects and Adverse Reactions-accompanied-Kidney Diseases', 'Drug-Related Side Effects and Adverse Reactions-accompanied-Cardiovascular Diseases', 'Drug-Related Side Effects and Adverse Reactions-accompanied-Neoplasms', 'Drug-Related Side Effects and Adverse Reactions-accompanied-Liver Diseases', 'Drug-Related Side Effects and Adverse Reactions-emerge-Death', 'Kidney Diseases-emerge-Death', 'Kidney Diseases-considered-Drug-Related Side Effects and Adverse Reactions', 'Neoplasms-emerge-Death', 'Gastrointestinal Hemorrhage-carry-Death', 'Gastrointestinal Hemorrhage-carry-Hypertension', 'Gastrointestinal Hemorrhage-carry-Fibrosis', 'Fibrosis-blee-Gastrointestinal Hemorrhage', 'Hepatic Encephalopathy-reble-Death', 'Chronic Disease-achieve-Weight Loss', 'Spinal Cord Neoplasms-affect-Neoplasms', 'Pain-treated-Neoplasm Metastasis', 'Nervous System Diseases-treated-Neoplasm Metastasis', 'Chronic Disease-contribute-Phenylketonurias', 'Death-related-Liver Neoplasms', 'Venous Thrombosis-constitute-Primary Myelofibrosis', 'Liver Neoplasms-associated-HIV Infections', 'HIV Infections-associated-Liver Neoplasms', 'Venous Thrombosis-constitute-Leukemia, Myeloid, Acute', 'Death-constitute-Primary Myelofibrosis', 'Death-constitute-Leukemia, Myeloid, Acute', 'Hematologic Diseases-lead-Thrombosis', 'Thrombophilia-lead-Thrombosis', 'Fatty Liver-include-Chronic Disease', 'Contracture-characterized-Talipes Cavus', 'Infections-include-Hepatitis B', 'Prostatic Neoplasms-show-Neoplasm Metastasis', 'Arthritis, Rheumatoid-include-Infections', 'Arthritis, Rheumatoid-include-Hepatitis B', 'Testicular Neoplasms-noted-Neoplasms', 'Testicular Neoplasms-noted-Seminoma', 'Renal Insufficiency-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-Renal Insufficiency', 'Renal Insufficiency, Chronic-considered-Coronary Artery Disease', 'Kidney Failure, Chronic-experience-Death', 'Death-compare-Kidney Failure, Chronic', 'Inflammation-persist-Cardiovascular Diseases', 'Dyslipidemias-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-Dyslipidemias', 'Neoplasm Metastasis-develop-Death', 'Acquired Immunodeficiency Syndrome-limited-Drug-Related Side Effects and Adverse Reactions', 'Prostatic Neoplasms-defined-Urinary Bladder Diseases', 'Neoplasms-defined-Urinary Bladder Diseases', 'Polycystic Kidney Diseases-affect-Kidney Diseases', 'Genetic Diseases, Inborn-affect-Kidney Diseases', 'Spondylitis, Ankylosing-include-Inflammation', 'Polycystic Kidney, Autosomal Recessive-belong-Hepatorenal Syndrome', 'Thrombocythemia, Essential-consider-Polycythemia Vera', 'Polycythemia Vera-increase-Thrombosis', 'Primary Myelofibrosis-show-Thrombocythemia, Essential', 'Thrombocythemia, Essential-reveal-Primary Myelofibrosis', 'Thrombocythemia, Essential-reveal-Polycythemia Vera', 'Lupus Erythematosus, Systemic-considered-Communicable Diseases', 'Neoplasms-displayed-Sarcoma, Kaposi', 'Neoplasms-displayed-Urinary Bladder Neoplasms', 'Sarcoma, Kaposi-entail-Pancreatitis, Graft', 'Neoplasms-displayed-Breast Neoplasms', 'Wounds and Injuries-evoked-Ischemia', 'Wounds and Injuries-implicated-Neurodegenerative Diseases', 'Ischemia-implicated-Neurodegenerative Diseases', 'Ischemia-implicated-Amyotrophic Lateral Sclerosis', 'Neoplasms-avoid-Dehydration', 'Amnesia-produce-Memory Disorders', 'Amnesia-produce-Alzheimer Disease', 'Amnesia-produce-Dementia', 'Hemophilia A-recognised-von Willebrand Diseases', 'Consciousness Disorders-emerge-Alzheimer Disease', 'Memory Disorders-ungraded-Alzheimer Disease', 'Consciousness Disorders-emerge-Dementia', 'Hemophilia B-recognised-von Willebrand Diseases', 'Memory Disorders-grade-Dementia', 'Neutropenia-reduce-Infections', 'Amnesia-vary-Cerebral Infarction', 'HIV Infections-become-Rheumatic Diseases', 'HIV Infections-become-Osteoporosis', 'HIV Infections-become-Osteonecrosis', 'HIV Infections-become-Gout', 'Amnesia-investigate-Neurodegenerative Diseases', 'HIV Infections-become-Eye Infections, Fungal', 'Neutropenia-lead-Infections', 'Hemangiosarcoma-cause-Carcinogenesis', 'Hemangiosarcoma-cause-Lymphoma', 'Hemangiosarcoma-cause-Leukemia', 'Neoplasms-cause-Lymphoma', 'Neoplasms-cause-Leukemia', 'Carcinogenesis-produce-Lymphoma', 'Malnutrition-thrive-Pneumonia', 'Carcinogenesis-cause-Leukemia', 'Malnutrition-thrive-Communicable Diseases', 'Neoplasms-develop-Sleep Disorders, Circadian Rhythm', 'Neoplasms-induce-Neoplasm Metastasis', 'Arthritis-exclude-Back Pain', 'Rheumatic Diseases-exclude-Back Pain', 'Drug-Related Side Effects and Adverse Reactions-observed-Arthralgia', 'Myalgia-observed-Arthralgia', 'Kidney Diseases-lead-Bacteriuria', 'Thrombosis-include-Thrombocytosis', 'Hypertension-account-Cardiovascular Diseases', 'Death-include-Death, Sudden', 'Bone Diseases, Metabolic-see-Hip Dislocation, Congenital', 'Gaucher Disease-see-Hip Dislocation, Congenital', 'Aneurysm-based-Rupture', 'Heart Arrest-treat-Aneurysm', 'Polycythemia Vera-prevent-Thrombosis', 'Thrombocytosis-prevent-Thrombosis', 'Unconsciousness-admitted-Coma', 'Death-continue-Unconsciousness', 'Unconsciousness-continue-Death', 'Neoplasms-assessed-Fractures, Bone', 'Lung Neoplasms-induce-Colonic Neoplasms', 'Death-analyzed-Hemochromatosis', 'Neoplasms-studied-Genetic Diseases, Inborn', 'Infections-seen-Acquired Immunodeficiency Syndrome', 'Coronary Artery Disease-associated-Heart Defects, Congenital', 'Heart Defects, Congenital-associated-Coronary Artery Disease', 'Cystic Fibrosis-inherited-Genetic Diseases, Inborn', 'Pain-delayed-Drug Overdose', 'Fever-prompt-Death', 'Muscular Atrophy, Spinal-cause-Death', 'Neoplasm Metastasis-occur-Lung Neoplasms', 'Chronic Disease-initiated-Joint Diseases', 'Neoplasm Metastasis-compare-Death', 'Muscle Weakness-related-Chronic Kidney Disease-Mineral and Bone Disorder', 'Muscle Weakness-observed-Chronic Kidney Disease-Mineral and Bone Disorder', 'Diabetes Mellitus-associated-Cerebrospinal Fluid Rhinorrhea', 'Cerebrospinal Fluid Rhinorrhea-associated-Diabetes Mellitus', 'Opioid-Related Disorders-examine-Death', 'Diabetes Mellitus-accounted-Prediabetic State', 'Diabetes Mellitus-decrease-Hypertension', 'Skin Neoplasms-associated-Cataract', 'Cataract-associated-Skin Neoplasms', 'Sensation Disorders-occur-Hearing Loss', 'Hypertension-exceed-Diabetes Mellitus', 'Death-recorded-Pneumonia', 'Death-include-Acute Kidney Injury', 'Death-include-Lupus Erythematosus, Systemic', 'Death-include-Aortic Valve Insufficiency', 'Death-include-Catatonia', 'Hypotension-live-HIV Infections', 'Heart Failure-live-HIV Infections', 'Osteoporosis-investigate-Osteoarthritis', 'Cardiovascular Diseases-investigate-Osteoarthritis', 'Hypotension, Orthostatic-investigate-Osteoarthritis', 'Uterine Cervical Neoplasms-compare-Neoplasms', 'Inflammation-limit-Fibrosis', 'Gastric Outlet Obstruction-cause-Nausea', 'Gastric Outlet Obstruction-cause-Vomiting', 'Gastric Outlet Obstruction-cause-Abdominal Pain', 'Cachexia-contribute-Neoplasms', 'Arthritis, Rheumatoid-increase-Death', 'Arthritis, Rheumatoid-increase-Respiratory Tract Diseases', 'Cardiovascular Diseases-coexist-Parkinson Disease', 'Pain-compare-Arthritis, Psoriatic', 'Pain-account-Arthritis, Psoriatic', 'Glioblastoma-improve-Neoplasms', 'Drug-Related Side Effects and Adverse Reactions-reduce-Glioblastoma', 'Anophthalmos-exhibit-Retinal Degeneration', 'Edema-lead-Nerve Degeneration', 'Lupus Erythematosus, Systemic-suffer-Cardiovascular Diseases', 'Osteoporosis-explore-Diabetes Mellitus, Type 2', 'Osteoporosis-explore-Diabetes Mellitus', 'Communicable Diseases-project-Death', 'Osteoporosis-fall-Diabetes Mellitus', 'Osteoarthritis-project-Death', 'Coronary Artery Disease-project-Death', 'Fractures, Bone-increased-Diabetes Mellitus, Type 2', 'Neoplasms-project-Death', 'Pulmonary Disease, Chronic Obstructive-project-Death', 'Cerebrovascular Disorders-project-Death', 'Dementia-project-Death', 'Diabetes Mellitus-project-Death', 'Pain-project-Death', 'Heart Failure-project-Death', 'AIDS Arteritis, Central Nervous System-arise-HIV Infections', 'AIDS Arteritis, Central Nervous System-treat-HIV Infections', 'Mitochondrial Diseases-associated-AIDS Arteritis, Central Nervous System', 'AIDS Arteritis, Central Nervous System-associated-Mitochondrial Diseases', 'Arthritis, Rheumatoid-lead-Fractures, Bone', 'Lung Neoplasms-assessed-Carcinoma, Non-Small-Cell Lung', 'Lung Neoplasms-assessed-Carcinoma, Small Cell', 'Hallucinations-include-Dementia', 'Psychoses, Substance-Induced-treat-Hallucinations', 'Myocardial Infarction-compared-Diabetes Mellitus', 'Death-verified-Colonic Neoplasms', 'Stroke-compared-Diabetes Mellitus', 'Death-verified-Diabetes Mellitus', 'Heart Failure-compared-Diabetes Mellitus', 'Colonic Neoplasms-increase-Death', 'Breast Neoplasms-increase-Respiratory Tract Diseases', 'Neoplasms-increase-Respiratory Tract Diseases', 'Idiopathic Pulmonary Fibrosis-affected-Coronary Artery Disease', 'Idiopathic Pulmonary Fibrosis-affected-Hypertension, Pulmonary', 'Heart Diseases-increased-Death', 'Stroke-increased-Death', 'Lung Neoplasms-affected-Idiopathic Pulmonary Fibrosis', 'Death-merit-Chronic Kidney Disease-Mineral and Bone Disorder', 'Hypertension-merit-Chronic Kidney Disease-Mineral and Bone Disorder', 'Chronic Kidney Disease-Mineral and Bone Disorder-merit-Cardiovascular Diseases', 'Tourette Syndrome-experience-Tic Disorders', 'Nocturia-assess-Urinary Bladder, Overactive', 'Graft vs Host Disease-associate-Neoplasms', 'Neoplasms-associate-Graft vs Host Disease', 'Graft vs Host Disease-associate-Inflammatory Bowel Diseases', 'Inflammatory Bowel Diseases-associate-Graft vs Host Disease', 'Inflammatory Bowel Diseases-lead-Neoplasms', 'Cervical Intraepithelial Neoplasia-lead-Neoplasms', 'Inflammatory Bowel Diseases-recommend-Lupus Erythematosus, Systemic', 'Inflammatory Bowel Diseases-publish-Neoplasms', 'Inflammatory Bowel Diseases-take-Lupus Erythematosus, Systemic', 'Lupus Erythematosus, Systemic-recommend-Arthritis, Rheumatoid', 'Lupus Erythematosus, Systemic-publish-Neoplasms', 'Lupus Erythematosus, Systemic-recommend-Neoplasms', 'Arthritis, Rheumatoid-publish-Neoplasms', 'Arthritis, Rheumatoid-take-Lupus Erythematosus, Systemic', 'Neoplasms-take-Lupus Erythematosus, Systemic', 'Graft vs Host Disease-result-Inflammatory Bowel Diseases', 'Arthritis, Rheumatoid-increase-Diabetes Mellitus, Type 1', 'Arthritis, Rheumatoid-follow-Cervical Intraepithelial Neoplasia', 'Lupus Erythematosus, Systemic-take-Arthritis, Rheumatoid', 'Arthritis, Rheumatoid-follow-Neoplasms', 'Inflammatory Bowel Diseases-result-Cervical Intraepithelial Neoplasia', 'Arthritis, Rheumatoid-increase-Myotonic Dystrophy', 'Diabetes Mellitus, Type 1-increase-Cervical Intraepithelial Neoplasia', 'Diabetes Mellitus, Type 1-increase-Neoplasms', 'Cervical Intraepithelial Neoplasia-increase-Myotonic Dystrophy', 'Neoplasms-increase-Myotonic Dystrophy', 'Myotonic Dystrophy-associate-Cervical Intraepithelial Neoplasia', 'Cervical Intraepithelial Neoplasia-associate-Myotonic Dystrophy', 'Myotonic Dystrophy-associate-Neoplasms', 'Neoplasms-associate-Myotonic Dystrophy', 'Dementia-select-Alzheimer Disease', 'Fistula-treated-Infections', 'Neuroendocrine Tumors-associated-Death', 'Death-associated-Neuroendocrine Tumors', 'Chronic Disease-improved-Diabetes Mellitus', 'Cardiovascular Diseases-used-Neoplasms', 'Invasive Fungal Infections-prevent-Neutropenia', 'Hypertension-used-Neoplasms', 'Invasive Fungal Infections-prevent-Leukemia, Myeloid, Acute', 'Hypercholesterolemia-used-Neoplasms', 'Invasive Fungal Infections-prevent-Myelodysplastic Syndromes', 'Neutropenia-prevent-Leukemia, Myeloid, Acute', 'Neutropenia-prevent-Myelodysplastic Syndromes', 'Brain Diseases-result-Death', 'Prostatic Neoplasms-experience-Death', 'Atherosclerosis-involve-Thrombophilia', 'Atrial Fibrillation-review-Obesity', 'Atrial Fibrillation-review-Dyslipidemias', 'Atrial Fibrillation-review-Diabetes Mellitus', 'Thrombocythemia, Essential-include-Thrombosis', 'Mastocytosis-include-Mastocytosis, Systemic', 'Leukemia, Mast-Cell-include-Mastocytosis, Systemic', 'Pain-confirm-Neoplasm Metastasis', 'Neoplasms-estimated-Amyotrophic Lateral Sclerosis', 'Nervous System Diseases-related-Death', 'Death-followed-Coronary Artery Disease', 'Neoplasms-followed-Coronary Artery Disease', 'Myopia-reported-Glaucoma', 'Inflammation-termed-HIV-Associated Lipodystrophy Syndrome', 'Spastic Paraplegia, Hereditary-lead-Muscle Weakness', 'Spastic Paraplegia, Hereditary-lead-Muscle Spasticity', 'Fanconi Syndrome-progress-Kidney Diseases', 'Death-predicted-Autoimmune Diseases', 'Death-predicted-Gastrointestinal Diseases', 'Death-decrease-Heart Diseases', 'Cerebrovascular Disorders-cause-Death', 'Death-identified-Multiple Sclerosis', 'Alagille Syndrome-cause-Death', 'Shock, Septic-included-Sepsis', 'Anemia-play-Sepsis', 'Intracranial Hemorrhages-avoid-Death, Sudden', 'Death-avoid-Death, Sudden', 'Alagille Syndrome-avoid-Death, Sudden', 'Parkinson Disease-associated-Critical Illness', 'Critical Illness-associated-Parkinson Disease', 'Metabolic Syndrome-reduce-Carcinoma, Hepatocellular', 'Lung Neoplasms-develop-Airway Obstruction', 'Airway Obstruction-lead-Neoplasms', 'Nervous System Diseases-cause-Inflammation', 'Glioblastoma-give-Neoplasms', 'Gastritis, Atrophic-include-Malabsorption Syndromes', 'Metabolic Diseases-result-Pancreatitis', 'Death-induced-Malaria', 'Amyotrophic Lateral Sclerosis-counterbalance-Mitochondrial Diseases', 'Atherosclerosis-share-Rheumatic Diseases', 'Atherosclerosis-share-Arthritis, Rheumatoid', 'Amyotrophic Lateral Sclerosis-associated-Muscular Atrophy, Spinal', 'Muscular Atrophy, Spinal-associated-Amyotrophic Lateral Sclerosis', 'Infections-base-Cross Infection', 'Infections-defined-Cross Infection', 'Papilloma-follow-Focal Epithelial Hyperplasia', 'Ventricular Septal Rupture-give-Death', 'Melkersson-Rosenthal Syndrome-marked-Edema', 'Melkersson-Rosenthal Syndrome-marked-Facial Paralysis', 'Melkersson-Rosenthal Syndrome-confirmed-Granuloma', 'Granulomatosis, Orofacial-confirmed-Granuloma', 'Edema-include-Periodontal Diseases', 'Edema-include-Drug Hypersensitivity', 'Edema-include-Crohn Disease', 'Edema-include-Migraine Disorders', 'Edema-include-Lupus Erythematosus, Systemic', 'Liver Failure-consist-Death', 'Cystic Fibrosis-stratified-Obesity', 'Neoplasms-chosen-Anastomotic Leak', 'Neoplasms-recommended-Pain', 'Neoplasms-managed-Heart Block', 'Heart Block-recommended-Abdominal Pain', 'Heart Block-recommended-Neoplasms', 'Deafness-occur-Heredodegenerative Disorders, Nervous System', 'Cystic Fibrosis-present-Abdominal Pain', 'Kidney Diseases-identified-Aneurysm', 'Kidney Diseases-identified-Nephrosclerosis', 'Kidney Diseases-identified-Diabetes Mellitus', 'Priapism-mimic-Multiple Sclerosis', 'Cerebral Hemorrhage-underestimated-Stroke', 'Hemophilia A-prolong-Hemorrhage', 'Epilepsy-related-Neoplasm Metastasis', 'Alzheimer Disease-underlie-Nerve Degeneration', 'Arthritis, Psoriatic-become-Metabolic Syndrome', 'Arthritis, Psoriatic-become-Cardiovascular Diseases', 'Stroke-apply-Cerebral Palsy', 'Thalassemia-cause-Anemia, Hemolytic', 'Anodontia-cause-Anemia, Hemolytic', 'Neoplasms-inform-Diabetes Mellitus', 'Neoplasms-inform-Heart Failure', 'Neoplasms-inform-Stroke', 'Osteoarthritis-result-Wounds and Injuries', 'Immunologic Deficiency Syndromes-prevent-Drug-Related Side Effects and Adverse Reactions', 'Cardiovascular Diseases-needed-Stroke', 'Apraxia, Ideomotor-achieve-Chronic Disease', 'Cholangitis, Sclerosing-cause-Fibrosis', 'Inflammation-cause-Fibrosis', 'Colorectal Neoplasms-performed-Cholangitis, Sclerosing', 'Neoplasms-include-Cholangiocarcinoma', 'Neoplasms-include-Gallbladder Neoplasms', 'Coronary Artery Disease-complicate-Diabetes Mellitus', 'Infections-investigated-Immunologic Deficiency Syndromes', 'Aortic Aneurysm-based-Aneurysm, Ruptured', 'Aortic Aneurysm-based-Aneurysm', 'Aneurysm-based-Aneurysm, Ruptured', 'Immunologic Deficiency Syndromes-reduce-Infections', 'Rupture-fail-Aortic Aneurysm, Abdominal', 'Rupture-based-Aneurysm', 'Death-predict-Aneurysm', 'Aortic Aneurysm, Abdominal-protected-Death', 'Scoliosis-associated-Heart Diseases', 'Heart Diseases-associated-Scoliosis', 'Kidney Failure, Chronic-contribute-Cardiovascular Diseases', 'Obesity-arose-Death', 'Obesity-provide-Weight Loss', 'HIV Infections-infected-Death', 'Liver Diseases-treat-Hepatitis C', 'HIV Infections-treat-Hepatitis C', 'HIV Infections-contribute-Chemical and Drug Induced Liver Injury', 'Peri-Implantitis-related-Arrhythmias, Cardiac', 'Peri-Implantitis-related-Tachycardia, Supraventricular', 'Breast Neoplasms-model-Neoplasms', 'Myopia-include-Weill-Marchesani Syndrome', 'Myopia-include-Homocystinuria', 'Coronary Artery Disease-lead-Heart Failure', 'Death-increase-Fractures, Bone', 'Thrombocytopenia-studied-Myelodysplastic Syndromes', 'Diabetes Mellitus-protect-Atherosclerosis', 'Chemical and Drug Induced Liver Injury-protect-Atherosclerosis', 'Death-escape-Neoplasms', 'Diabetes Mellitus-increase-Liver Failure', 'Ischemia-protect-Aortic Aneurysm, Abdominal', 'Autoimmune Diseases-associated-Death', 'Death-associated-Autoimmune Diseases', 'Heart Failure-follow-Myocardial Infarction', 'Hemophilia A-remain-Death', 'Hemophilia A-remain-Intracranial Hemorrhages', 'Hemophilia A-remain-HIV Infections', 'Death-remain-Intracranial Hemorrhages', 'Intracranial Hemorrhages-remain-HIV Infections', 'HIV Infections-develop-Immunologic Deficiency Syndromes', 'Intermittent Claudication-treated-Pain', 'Intermittent Claudication-treated-Ischemia', 'Urinary Tract Infections-occur-Bacteriuria', 'Inflammation-suggest-Anemia', 'Cardiovascular Diseases-undersubscribed-Death', 'Inflammation-result-Thrombocytosis', 'Pancreatitis, Graft-develop-Aneurysm', 'Polyuria-improve-Signs and Symptoms, Respiratory', 'Polyuria-improve-Constipation', 'Polyuria-improve-Nausea', 'Polyuria-improve-Vomiting', 'Polyuria-improve-Anorexia', 'Vision Disorders-cause-Cardiovascular Abnormalities', 'Cerebrovascular Disorders-begin-Dementia', 'Cerebrovascular Disorders-obstruct-Headache Disorders, Secondary', 'Dementia-obstruct-Headache Disorders, Secondary', 'Toxemia-increased-Tuberculosis', 'Death-reduced-Coronary Artery Disease', 'Heart Diseases-rank-Neoplasms', 'Bone Marrow Neoplasms-foreshadow-Death', 'Adrenal Insufficiency-vary-Bone Marrow Diseases', 'Adrenal Insufficiency-remain-Death', 'Anemia, Aplastic-vary-Bone Marrow Diseases', 'Anemia, Aplastic-remain-Death', 'Bone Marrow Diseases-remain-Death', 'Gastric Outlet Obstruction-caused-Neoplasm Metastasis', 'Neoplasms-transplanted-Breast Neoplasms', 'Malocclusion-confirmed-Nijmegen Breakage Syndrome', 'Renal Insufficiency-include-Acute Chest Syndrome', 'Renal Insufficiency-include-Stroke', 'Shock, Hemorrhagic-associated-Sepsis', 'Sepsis-associated-Shock, Hemorrhagic', 'Hyperlipidemias-associated-Immunologic Deficiency Syndromes', 'Immunologic Deficiency Syndromes-associated-Hyperlipidemias', 'Hypertension-associated-Immunologic Deficiency Syndromes', 'Immunologic Deficiency Syndromes-associated-Hypertension', 'Diabetes Mellitus-associated-Acquired Immunodeficiency Syndrome', 'Acquired Immunodeficiency Syndrome-associated-Diabetes Mellitus', 'Hyperlipidemias-associated-Acquired Immunodeficiency Syndrome', 'Acquired Immunodeficiency Syndrome-associated-Hyperlipidemias', 'Hypertension-associated-Acquired Immunodeficiency Syndrome', 'Acquired Immunodeficiency Syndrome-associated-Hypertension', 'Cardiovascular Diseases-associated-Acquired Immunodeficiency Syndrome', 'Acquired Immunodeficiency Syndrome-associated-Cardiovascular Diseases', 'Hyperuricemia-promote-Inflammation', 'Dementia-resemble-Seizures', 'Hyperuricemia-promote-Death', 'Death-detect-Neoplasms', 'Breast Neoplasms-detect-Neoplasms', 'Glioblastoma-associated-Neoplasms', 'Neoplasms-associated-Glioblastoma', 'Muscle Weakness-recorded-Death', 'Airway Obstruction-result-Lung Diseases', 'Glioblastoma-regulate-Neoplasms', 'Death-contribute-Cardiomyopathies', 'Muscular Dystrophy, Duchenne-manifest-Muscle Weakness', 'Muscular Dystrophy, Duchenne-manifest-Dystonia', 'Muscle Weakness-manifest-Cardiomyopathy, Dilated', 'Death-related-Muscular Dystrophy, Duchenne', 'Dystonia-manifest-Cardiomyopathy, Dilated', 'Stomach Neoplasms-increase-Drug-Related Side Effects and Adverse Reactions', 'Death-needed-Diabetes Mellitus', 'Heart Failure-account-Death, Sudden', 'Gait Disorders, Neurologic-related-Motor Neuron Disease', 'Gait Disorders, Neurologic-related-Communicable Diseases', 'Metabolic Syndrome-estimate-Hypotension', 'Tuberculosis-suffer-Lung Diseases', 'Neoplasms-elaborated-Breast Neoplasms', 'Neoplasms-discussed-Breast Neoplasms', 'Nervous System Diseases-cause-Death', 'Weight Loss-live-Pain', 'Dehydration-live-Pain', 'Neoplasms-detected-Ovarian Neoplasms', 'Pain-live-Diabetes Mellitus', 'Pain-live-Heart Failure', 'Pain-live-Obesity', 'Psychoses, Substance-Induced-associate-Death', 'Death-associate-Psychoses, Substance-Induced', 'Hyperlipidemias-increase-Stroke', 'Otitis-reported-Hearing Loss', 'Coronary Artery Disease-compared-Familial Mediterranean Fever', 'Coronary Artery Disease-diagnosed-Familial Mediterranean Fever', 'Cerebral Small Vessel Diseases-involve-Diabetes Mellitus', 'Diabetes Mellitus-show-Chemical and Drug Induced Liver Injury', 'Diabetes Mellitus-show-Liver Cirrhosis', 'Diabetes Mellitus-show-Carcinoma, Hepatocellular', 'Cerebral Infarction-achieve-Venous Thrombosis', 'Ehlers-Danlos Syndrome-manage-Collagen Diseases', 'Respiratory Tract Diseases-follow-Death', 'Death-exhaust-Weight Loss', 'Melanoma-enable-Neoplasms', 'Colonic Neoplasms-enable-Neoplasms', 'Pain-induced-Neoplasms', 'Chemical and Drug Induced Liver Injury-co-infected-HIV Infections', 'Neoplasms-convert-Pain', 'Diabetes Mellitus-present-Seizures', 'HIV Infections-cause-Liver Diseases', 'Liver Diseases-cause-Immunologic Deficiency Syndromes', 'Neoplasms-expressed-Prostatic Neoplasms', 'Neoplasms-inhibit-Melanoma', 'Cholangitis-identified-Thrombosis', 'Cardiovascular Diseases-exposed-Obesity', 'Melanoma-diminished-Neoplasms', 'Neoplasms-seen-Coronary Artery Disease', 'Spinocerebellar Ataxias-known-Machado-Joseph Disease', 'Machado-Joseph Disease-known-Nervous System Diseases', 'Dementia-hast-Alzheimer Disease', 'Neurodegenerative Diseases-reduce-Machado-Joseph Disease', 'Drug-Related Side Effects and Adverse Reactions-hast-Alzheimer Disease', 'Obesity-linked-Weight Gain', 'Communicable Diseases-show-Nervous System Diseases', 'Neurodegenerative Diseases-accompanied-Gliosis', 'Gliosis-accompanied-Communicable Diseases', 'Osteoporotic Fractures-cause-Low Back Pain', 'Osteoporosis-induce-Fractures, Stress', 'Nerve Degeneration-suggest-Cerebellar Diseases', 'Pulmonary Aspergillosis-affect-Tuberculosis', 'Pain-experience-Fractures, Stress', 'Pain-experience-Osteoporosis', 'Fractures, Stress-experience-Osteoporosis', 'Cerebrovascular Disorders-include-Brain Diseases', 'Coronary Artery Disease-encountered-Heart Diseases', 'Death-focus-Carcinoma, Hepatocellular', 'Diabetes Mellitus-promote-Cerebrovascular Disorders', 'Neurodegenerative Diseases-exhibit-Gait Disorders, Neurologic', 'Neoplasms-indicate-Carcinogenesis', 'Fat Necrosis-associated-Adenocarcinoma', 'Adenocarcinoma-associated-Fat Necrosis', 'Fat Necrosis-associated-Colorectal Neoplasms', 'Colorectal Neoplasms-associated-Fat Necrosis', 'Fat Necrosis-associated-Pancreatic Neoplasms', 'Pancreatic Neoplasms-associated-Fat Necrosis', 'Fat Necrosis-associated-Prostatic Neoplasms', 'Prostatic Neoplasms-associated-Fat Necrosis', 'Joint Diseases-related-Hemophilia A', 'Death-operated-Hematoma, Subdural, Acute', 'Neoplasms-exacerbated-Muscular Diseases', 'Neoplasms-exacerbated-Cachexia', 'Muscular Diseases-exacerbated-Cachexia', 'Muscular Diseases-accelerate-Death', 'Cachexia-accelerate-Death', 'Death-eliminate-Obesity, Abdominal', 'Death-observed-End Stage Liver Disease', 'Death-remove-Neoplasms', 'AIDS Arteritis, Central Nervous System-include-Stroke', 'Intestinal Diseases-associated-Liver Diseases', 'Liver Diseases-associated-Intestinal Diseases', 'Intestinal Diseases-recognize-Sepsis', 'Liver Diseases-recognize-Sepsis', 'Intestinal Diseases-cause-Blind Loop Syndrome', 'Intestinal Diseases-cause-Liver Cirrhosis', 'Pancreatic Neoplasms-develop-Neoplasms', 'Airway Obstruction-improve-Death', 'Adenocarcinoma-undergo-Carcinoma, Squamous Cell', 'Neoplasms-followed-Hemophilia A', 'Meningitis-associated-Neoplasms', 'Neoplasms-associated-Meningitis', 'Hemorrhage-follow-Hemostatic Disorders', 'Hemorrhage-occur-Hemostatic Disorders', 'Neoplasms-burdened-Drug-Related Side Effects and Adverse Reactions', 'HIV Infections-change-Lung Diseases', 'HIV Infections-change-Pneumonia, Pneumocystis', 'Epilepsy, Absence-expose-Infections', 'HIV Infections-change-Pneumonia', 'Cystic Fibrosis-cause-Infertility, Female', 'HIV Infections-predominate-Tuberculosis', 'Lung Diseases-change-Pneumonia, Pneumocystis', 'Lung Diseases-change-Pneumonia', 'Lung Diseases-predominate-Tuberculosis', 'Pneumonia, Pneumocystis-predominate-Tuberculosis', 'Pneumonia-predominate-Tuberculosis', 'Diabetes Mellitus-brought-Weight Gain', 'Coronary Artery Disease-followed-Communicable Diseases', 'Coronary Artery Disease-followed-Acquired Immunodeficiency Syndrome', 'Inflammation-triggered-Arbovirus Infections', 'Aneurysm-predispose-Dementia', 'Dementia-favor-Aneurysm', 'Atherosclerosis-favor-Aneurysm', 'Cystic Fibrosis-influence-Lung Diseases', 'Hemoptysis-related-Cystic Fibrosis', 'Death-address-HIV Infections', 'Melanoma-detect-Neoplasms', 'Stomach Neoplasms-offset-Neoplasms', 'Obesity-impair-Diabetes Mellitus', 'Ulcer-experience-Neuralgia', 'Cystic Fibrosis-target-Respiratory Tract Infections', 'Cystic Fibrosis-target-Inflammation', 'Ataxia-diagnosed-Wolfram Syndrome', 'Brain Injuries, Traumatic-fit-Seizures', 'Chronic Disease-fit-Seizures', 'Brain Injuries, Traumatic-managed-Chronic Disease', 'Hemophilia B-characterized-Coagulation Protein Disorders', 'Syncope-related-Hypoglycemia', 'Hemophilia A-diagnosed-Neoplasms', 'Hemophilia A-diagnosed-Meningoencephalitis', 'Hemophilia A-diagnosed-Edema', 'Drug-Related Side Effects and Adverse Reactions-proposed-Neurodegenerative Diseases', 'Drug-Related Side Effects and Adverse Reactions-test-Amyotrophic Lateral Sclerosis', 'Alzheimer Disease-spent-Dementia', 'Dementia-spent-Alzheimer Disease', 'Death-expected-Alzheimer Disease', 'Alzheimer Disease-spend-Dementia', 'Death-result-Aortic Aneurysm', 'Neoplasms-cause-Airway Obstruction', 'Neoplasms-metastasize-Neoplasm Metastasis', 'Neoplasms-metastasize-Death', 'Atherosclerosis-establish-Inflammation', 'Dyslipidemias-attributed-Atherosclerosis', 'Diabetes Mellitus-attributed-Atherosclerosis', 'Pulmonary Embolism-develop-Thrombophilia', 'Thrombosis-develop-Thrombophilia', 'Neoplasms-show-Epstein-Barr Virus Infections', 'Amyotrophic Lateral Sclerosis-begin-Nerve Degeneration', 'Nerve Degeneration-begin-Death', 'Basal Ganglia Diseases-involve-Nerve Degeneration', 'Stroke-caused-Basal Ganglia Cerebrovascular Disease', 'Heart Diseases-caused-Basal Ganglia Cerebrovascular Disease', 'Kidney Diseases-caused-Basal Ganglia Cerebrovascular Disease', 'Color Vision Defects-include-Drug Hypersensitivity', 'Pruritus-include-Drug Hypersensitivity', 'Pain-include-Drug Hypersensitivity', 'Gastrointestinal Diseases-associated-Inflammatory Bowel Diseases', 'Inflammatory Bowel Diseases-associated-Gastrointestinal Diseases', 'Metabolism, Inborn Errors-result-Cardiomyopathies', 'Metabolism, Inborn Errors-result-Muscular Diseases', 'Metabolism, Inborn Errors-suffer-Muscular Diseases', 'Metabolism, Inborn Errors-experience-Respiratory Insufficiency', 'Muscular Diseases-experience-Respiratory Insufficiency', 'Femoral Neuropathy-associated-Death, Sudden, Cardiac', 'Death, Sudden, Cardiac-associated-Femoral Neuropathy', 'Death-appear-Death, Sudden, Cardiac', 'Heart Diseases-considered-Death, Sudden, Cardiac', 'Kidney Diseases-assess-Hypertension', 'Kidney Diseases-followed-Hypertension', 'Kidney Diseases-assess-Diabetes Mellitus', 'Vision Disorders-receive-Kidney Diseases', 'Foot Diseases-considered-Hypotension', 'Hemophilia A-predispose-Heart Diseases', 'Heart Diseases-associated-HIV Infections', 'HIV Infections-associated-Heart Diseases', 'Infections-predispose-Heart Diseases', 'HIV Infections-predispose-Heart Diseases', 'Heart Diseases-associated-Hemophilia B', 'Hemophilia B-associated-Heart Diseases', 'Diabetes Mellitus-detected-Fibrosis', 'Diabetes Mellitus-detected-Hepatitis B', 'Hemochromatosis-established-Fibrosis', 'Huntington Disease-caused-Neurodegenerative Diseases', 'Mouth Diseases-associated-Tooth Loss', 'Tooth Loss-associated-Mouth Diseases', 'Multiple Sclerosis-cause-Demyelinating Diseases', 'Heredodegenerative Disorders, Nervous System-cause-Demyelinating Diseases', 'Turner Syndrome-suggest-Coronary Artery Disease', 'Communicable Diseases-result-Pelvic Neoplasms', 'Communicable Diseases-result-Pain', 'Communicable Diseases-result-Airway Obstruction', 'Obesity-suffer-Weight Loss', 'Weight Loss-desire-Musculoskeletal Diseases', 'Hemophilia A-increase-HIV Infections', 'Musculoskeletal Diseases-treat-Obesity', 'Walker-Warburg Syndrome-characterized-Lissencephaly', 'Walker-Warburg Syndrome-characterized-Retinitis', 'Walker-Warburg Syndrome-characterized-Muscular Dystrophies', 'Genetic Diseases, Inborn-characterized-Lissencephaly', 'Genetic Diseases, Inborn-characterized-Retinitis', 'Genetic Diseases, Inborn-characterized-Muscular Dystrophies', 'Carcinoma, Hepatocellular-carry-Hepatic Insufficiency', 'Breast Neoplasms-seem-Pain', 'Acquired Immunodeficiency Syndrome-increase-Death', 'Atrophy-caused-Retinal Degeneration', 'Acquired Immunodeficiency Syndrome-influence-Infections', 'Death-damaging-Infections', 'Retinal Degeneration-show-Alzheimer Disease', 'Hemochromatosis-diagnose-Liver Cirrhosis', 'Hemochromatosis-avert-Chronic Disease', 'Liver Cirrhosis-avert-Chronic Disease', 'Neoplasms-diagnosed-Carcinoma, Ovarian Epithelial', 'Death-caused-Aneurysm', 'Death-cause-Liver Failure', 'Cardiovascular Diseases-compared-Diabetes Mellitus, Type 1', 'Cardiovascular Diseases-compared-Diabetes Mellitus', 'Death-compared-Diabetes Mellitus, Type 1', 'Cardiovascular Diseases-develop-Kidney Diseases', 'Death-develop-Kidney Diseases', 'Diabetes Mellitus, Type 1-develop-Kidney Diseases', 'Brain Injuries-define-Metabolic Diseases', 'Brain Injuries-define-Abnormalities, Drug-Induced', 'Neurodegenerative Diseases-define-Metabolic Diseases', 'Neurodegenerative Diseases-define-Abnormalities, Drug-Induced', 'Hyperinsulinism-accelerate-Atherosclerosis', 'End Stage Liver Disease-combined-Lung Neoplasms', 'Stroke-identify-Constriction, Pathologic', 'Heart Defects, Congenital-occur-Death', 'Heart Diseases-omitted-Shock', 'Scoliosis-associated-Muscular Dystrophy, Duchenne', 'Muscular Dystrophy, Duchenne-associated-Scoliosis', 'Scoliosis-develop-Mobility Limitation', 'Death-balance-Leukemia, Myelogenous, Chronic, BCR-ABL Positive', 'Breast Neoplasms-related-Neoplasms', 'Neoplasm Metastasis-investigated-Breast Neoplasms', 'Neoplasm Metastasis-established-Breast Neoplasms', 'Pain-temporize-Neoplasm Metastasis', 'Leukemia, Myeloid-associated-HIV Infections', 'HIV Infections-associated-Leukemia, Myeloid', 'Myelodysplastic Syndromes-associated-HIV Infections', 'HIV Infections-associated-Myelodysplastic Syndromes', 'Leukemia, Myeloid, Acute-associated-HIV Infections', 'HIV Infections-associated-Leukemia, Myeloid, Acute', 'Optic Atrophy-include-Williams Syndrome', 'Hearing Loss-include-Williams Syndrome', 'Diabetes Mellitus-include-Williams Syndrome', 'Sarcopenia-remain-Cardiovascular Diseases', 'Fasciculation-related-Cardiovascular Diseases', 'Fasciculation-remain-Cardiovascular Diseases', 'Ischemia-lead-Death', 'Ischemia-associated-Glioma', 'Glioma-associated-Ischemia', 'Ischemia-underlie-Hypertension', 'Glioma-underlie-Hypertension', 'Myotonic Dystrophy-reflect-Diabetes Mellitus', 'Myotonic Dystrophy-linked-Cardiovascular Diseases', 'Placenta Diseases-contribute-Brain Injuries', 'Brain Injuries, Traumatic-associated-Atrophy', 'Atrophy-associated-Brain Injuries, Traumatic', 'Brain Injuries, Traumatic-caused-Atrophy', 'Blood Platelet Disorders-result-Hemorrhage', 'Neurologic Manifestations-result-Hemorrhage', 'Coronary Artery Disease-related-Death', 'Leukemia, Myeloid, Acute-improve-Death', 'Multiple Myeloma-identify-Drug-Related Side Effects and Adverse Reactions', 'Wounds and Injuries-evaluate-Pain', 'Wounds and Injuries-evaluate-Fatigue', 'Pyonephrosis-reveal-Death', 'Hypertension, Pulmonary-defined-Stenosis, Pulmonary Artery', 'Hypertension, Pulmonary-estimate-HIV Infections', 'Pain-assess-Nociceptive Pain', 'Quadriplegia-live-Paraplegia', 'Quadriplegia-live-Stroke', 'Quadriplegia-live-Lung Injury', 'Quadriplegia-live-Dementia', 'Hypertrophy-recapitulate-Weight Loss', 'Hypertrophy-predict-Metabolic Syndrome', 'Weight Gain-predict-Metabolic Syndrome', 'Renal Insufficiency, Chronic-suffer-Chronic Disease', 'Muscle Cramp-associated-Peripheral Nervous System Diseases', 'Peripheral Nervous System Diseases-associated-Muscle Cramp', 'Diabetes Mellitus-begin-Hyperglycemia', 'Inflammation-addressed-Stroke', 'Inflammation-derived-Stroke', 'Metabolic Diseases-characterized-Sleep Initiation and Maintenance Disorders', 'Leigh Disease-respond-Death', 'Central Nervous System Neoplasms-treated-Huntington Disease', 'Neoplasms-experience-Fractures, Open', 'Muscular Diseases-include-Muscular Dystrophies', 'Death-increased-Vascular Calcification', 'Muscular Diseases-include-Myotonia Congenita', 'Death-indicate-Coronary Artery Disease', 'Death-related-Lithiasis', 'Carcinoma, Hepatocellular-improve-Neoplasms', 'HIV Infections-contribute-Bone Neoplasms', 'Fractures, Bone-indicated-HIV Infections', 'Cardiomyopathies-cause-Fasciculation', 'HIV Infections-infected-Leishmaniasis', 'Lung Diseases-characterized-Idiopathic Pulmonary Fibrosis', 'Lung Diseases-include-Pulmonary Fibrosis', 'Cardiovascular Diseases-lost-Coronary Artery Disease', 'Autoimmune Diseases-improve-Muscular Dystrophy, Duchenne', 'Dementia-seen-Optic Atrophy, Hereditary, Leber', 'Colonic Neoplasms-report-Deglutition Disorders', 'Neoplasm Metastasis-defined-Liver Abscess', 'Neoplasm Metastasis-defined-Infections', 'Infections-examined-Drug-Related Side Effects and Adverse Reactions', 'Genetic Diseases, Inborn-characterised-Cerebellar Diseases', 'Motor Neuron Disease-cause-Muscular Atrophy', 'Motor Neuron Disease-cause-Paralysis', 'Motor Neuron Disease-cause-Respiratory Insufficiency', 'Heredodegenerative Disorders, Nervous System-cause-Muscular Atrophy', 'Heredodegenerative Disorders, Nervous System-cause-Paralysis', 'Heredodegenerative Disorders, Nervous System-cause-Respiratory Insufficiency', 'Hypoxia-require-End Stage Liver Disease', 'Hepatopulmonary Syndrome-associated-Death', 'Death-associated-Hepatopulmonary Syndrome', 'Cardiovascular Diseases-related-Dwarfism, Pituitary', 'Hypopituitarism-increase-Cardiovascular Diseases', 'Hypopituitarism-increase-Death', 'Neoplasms-represent-Glioma', 'Tooth, Impacted-result-Osteoporosis', 'Tooth, Impacted-result-Cardiovascular Diseases', 'Brain Diseases-reputed-Zoonoses', 'Muscular Atrophy, Spinal-associated-Muscle Weakness', 'Muscle Weakness-associated-Muscular Atrophy, Spinal', 'Muscular Atrophy, Spinal-associated-Atrophy', 'Atrophy-associated-Muscular Atrophy, Spinal', 'Wounds and Injuries-mediate-Compassion Fatigue', 'Breast Neoplasms-develop-Hemorrhage', 'HIV Infections-merit-Lymphoma, AIDS-Related', 'Death-cause-Scleroderma, Systemic', 'Death-improve-Autoimmune Diseases', 'Bulbo-Spinal Atrophy, X-Linked-demonstrate-Drug-Related Side Effects and Adverse Reactions', 'Diabetes Mellitus-cause-Femoral Neuropathy', 'Femoral Neuropathy-lead-Diabetes Mellitus', 'Nervous System Diseases-decrease-Diabetes Mellitus', 'Ischemia-remain-Death', 'Hip Fractures-ascertained-Death', 'Lysosomal Storage Diseases-vary-Bone Diseases, Developmental', 'Lysosomal Storage Diseases-vary-Nervous System Diseases', 'Vasculitis-associated-Asthma', 'Asthma-associated-Vasculitis', 'Vasculitis-associated-Eosinophilia', 'Eosinophilia-associated-Vasculitis', 'Acromegaly-reverse-Cardiovascular Diseases', 'Hypopituitarism-considered-Death', 'Hemophilia A-complicate-HIV Infections', 'Death-display-Neoplasms', 'Neurologic Manifestations-inhibit-Rupture', 'Muscle Weakness-lead-Respiratory Insufficiency', 'Atrophy-lead-Respiratory Insufficiency', 'Pulmonary Disease, Chronic Obstructive-caused-Arbovirus Infections', 'Neoplasms-discovered-Leukemia, Lymphocytic, Chronic, B-Cell', 'Neuroendocrine Tumors-represent-Neoplasms', 'Death-increased-Lung Diseases', 'Death-increased-Hypertension, Pulmonary', 'Muscle Weakness-receive-Glycogen Storage Disease Type II', 'Atrial Fibrillation-recommend-Stroke', 'Speech Disorders-receive-Glycogen Storage Disease Type II', 'Deglutition Disorders-receive-Glycogen Storage Disease Type II', 'Obesity-promote-Inflammation', 'Inflammation-precede-Diabetes Mellitus, Type 2', 'Sepsis-continue-Critical Illness', 'Inflammation-prevent-Diabetes Mellitus', 'Amyloidosis-associated-Neoplasms', 'Neoplasms-associated-Amyloidosis', 'Anemia-occur-Death', 'Anemia-treated-Malaria', 'Death-remain-Pulmonary Veno-Occlusive Disease', 'Liver Cirrhosis, Biliary-progress-Fibrosis', 'Liver Cirrhosis, Biliary-progress-Liver Failure', 'Liver Cirrhosis, Biliary-characterized-Cholestasis, Intrahepatic', 'Lung Diseases-reexpand-Pleural Effusion', 'Lung Neoplasms-base-Bone Neoplasms', 'Death-base-Bone Neoplasms', 'Diabetes Mellitus-develop-Stroke', 'Diabetes Mellitus-develop-Breast Neoplasms', 'Sexual Dysfunction, Physiological-attracted-Neoplasms', 'Diabetes Mellitus-related-Myocardial Infarction', 'Diabetes Mellitus-related-Stroke', 'beta-Thalassemia-compare-Thalassemia', 'Pain-control-Neoplasms', 'Cancer Pain-include-Delayed Emergence from Anesthesia', 'Coronary Artery Disease-compare-Acquired Immunodeficiency Syndrome', 'Neoplasms-initiate-Lung Neoplasms', 'Hemolytic-Uremic Syndrome-experience-Death', 'Neoplasms-include-Anemia', 'HIV Infections-cause-Glucose Metabolism Disorders', 'HIV Infections-promote-Atherosclerosis', 'Glucose Metabolism Disorders-promote-Atherosclerosis', 'Pain-excluded-Aneurysm', 'Rupture-excluded-Aneurysm', 'Lymphoproliferative Disorders-survive-Infections', 'Lymphoproliferative Disorders-develop-Lymphoma, B-Cell', 'Infections-develop-Lymphoma, B-Cell', 'Lymphoproliferative Disorders-experience-Epstein-Barr Virus Infections', 'Pulmonary Valve Insufficiency-lead-Arrhythmias, Cardiac', 'Amyotrophic Lateral Sclerosis-associated-Diabetes Mellitus', 'Diabetes Mellitus-associated-Amyotrophic Lateral Sclerosis', 'Wolff-Parkinson-White Syndrome-experience-Tachycardia', 'Wolff-Parkinson-White Syndrome-experience-Tachycardia, Supraventricular', 'Wolff-Parkinson-White Syndrome-experience-Atrial Fibrillation', 'Wolff-Parkinson-White Syndrome-experience-Atrial Flutter', 'Wolff-Parkinson-White Syndrome-experience-Ventricular Fibrillation', 'Wolff-Parkinson-White Syndrome-experience-Death, Sudden', 'Gingival Overgrowth-take-Metabolic Diseases', 'Gingival Overgrowth-associated-Fibroma', 'Fibroma-associated-Gingival Overgrowth', 'Metabolic Diseases-take-Fibroma', 'Intestinal Obstruction-include-Appendiceal Neoplasms', 'Appendicitis-delayed-Cystic Fibrosis', 'Intestinal Obstruction-include-Crohn Disease', 'Fibrosis-confined-Cystic Fibrosis', 'Intestinal Obstruction-include-Colonic Neoplasms', 'Appendicitis-delayed-Appendiceal Neoplasms', 'Cystic Fibrosis-delayed-Appendiceal Neoplasms', 'Prostatic Neoplasms-occur-Neoplasms', 'Diabetic Nephropathies-described-Diabetes Mellitus, Type 2', 'Diabetic Nephropathies-described-Hepatolenticular Degeneration', 'Prostatic Neoplasms-progress-Neoplasms', 'Kidney Diseases-live-Diabetes Mellitus, Type 1', 'Kidney Diseases-considered-Diabetes Mellitus, Type 2', 'Diabetes Mellitus, Type 2-increase-Diabetic Nephropathies', 'Prostatic Neoplasms-indicate-Death', 'Weight Loss-include-Death', 'Atherosclerosis-exhibit-Pain', 'Atherosclerosis-exhibit-Necrosis', 'Polycystic Kidney Diseases-lead-Renal Insufficiency', 'Polycystic Kidney Diseases-lead-Death', 'Renal Insufficiency-lead-Death', 'Motor Neuron Disease-made-Death', 'Hemorrhage-recur-Neoplasms', 'Myocardial Infarction-got-Infarction', 'Neoplasms-lead-Airway Obstruction', 'Parkinson Disease-indicate-Neurotoxicity Syndromes', 'Airway Obstruction-suffer-Pain', 'Infections-occur-Candidiasis', 'Death-see-Heart Failure', 'Arrhythmias, Cardiac-treated-Aneurysm', 'Hepatitis C-identified-Chemical and Drug Induced Liver Injury', 'Trichothiodystrophy Syndromes-found-Xeroderma Pigmentosum', 'Fractures, Bone-vary-Glaucoma, Open-Angle', 'Trichothiodystrophy Syndromes-characterized-Intellectual Disability', 'Atherosclerosis-estimated-Vascular Calcification', 'Neoplasms-identified-Dyspnea', 'Bone Neoplasms-include-Familial Hypophosphatemic Rickets', 'Bone Neoplasms-include-Osteogenesis Imperfecta', 'Dyspnea-improve-Neoplasms', 'Dyspnea-improve-Stomach Neoplasms', 'Bone Diseases, Metabolic-develop-Hypogonadism', 'Bone Diseases, Metabolic-develop-Neoplasms', 'Disease-diagnosed-Hypertension', 'Hypertension-target-Placenta Diseases', 'Placenta Diseases-cause-Inflammation', 'Neoplasms-ensure-Ovarian Neoplasms', 'Osteoporotic Fractures-pose-Fractures, Bone', 'Osteoporotic Fractures-pose-Death', 'Osteoporosis-result-Oculocerebrorenal Syndrome', 'Neurodegenerative Diseases-encompass-Cerebrovascular Disorders', 'Musculoskeletal Pain-categorized-Pain', 'Delirium-examine-Neoplasms', 'Delirium-undergo-Neoplasms', 'Psychomotor Agitation-undergo-Neoplasms', 'Psychomotor Agitation-follow-Neoplasms', 'Anemia-note-Neutropenia', 'Infections-affected-HIV Infections', 'Atrial Fibrillation-result-Cardiomyopathy, Dilated', 'Neoplasms-control-Cholestasis, Intrahepatic', 'Drug-Related Side Effects and Adverse Reactions-control-Cholestasis, Intrahepatic', 'Mucopolysaccharidosis III-include-Growth Disorders', 'Mucopolysaccharidosis III-include-Hernia', 'Mucopolysaccharidosis III-include-Hydrocephalus', 'Mucopolysaccharidosis III-include-Hearing Loss', 'Death-caused-Nervous System Diseases', 'Lissencephaly-lead-Intellectual Disability', 'Lissencephaly-lead-Epilepsy', 'Death-followed-Pulmonary Embolism', 'Death-followed-Urinary Tract Infections', 'Pneumonia-followed-Cardiac Complexes, Premature', 'Pneumonia-followed-Pulmonary Embolism', 'Spinal Cord Injuries-survive-Death', 'Spinal Cord Injuries-survive-Pneumonia', 'Death-compare-Pulmonary Arterial Hypertension', 'Hypertension, Pulmonary-identified-Death', 'Diabetes Mellitus-related-Anemia, Sickle Cell', 'Chronic Disease-driven-Cardiovascular Diseases', 'Kidney Diseases-investigate-Sleep Wake Disorders', 'Infertility, Female-voiced-Neoplasms', 'Hepatitis, Alcoholic-associated-Death', 'Death-associated-Hepatitis, Alcoholic', 'Dry Eye Syndromes-impair-Cataract', 'Cataract-present-Dystonia', 'Angiodysplasia-placed-Gastrointestinal Hemorrhage', 'Prostatic Neoplasms-predict-Death', 'Neurogenic Inflammation-cause-Death', 'Neurogenic Inflammation-lead-Neurodegenerative Diseases', 'Mitochondrial Diseases-lead-Neurodegenerative Diseases', 'Liver Diseases-caused-Hepatitis C', 'Liver Diseases-caused-Carcinoma, Hepatocellular', 'Carcinoma, Hepatocellular-include-Hepatitis C', 'Hepatitis C-enhance-Immunologic Deficiency Syndromes', 'Immunologic Deficiency Syndromes-worsen-Chemical and Drug Induced Liver Injury', 'Infections-remain-Carcinogenesis', 'Hepatitis C-associated-Chemical and Drug Induced Liver Injury', 'Chemical and Drug Induced Liver Injury-associated-Hepatitis C', 'Chemical and Drug Induced Liver Injury-worsen-Liver Diseases', 'Inflammation-associated-Weight Gain', 'Weight Gain-associated-Inflammation', 'Dyslipidemias-associated-Weight Gain', 'Weight Gain-associated-Dyslipidemias', 'Leukemia, Myeloid, Acute-threatening-Dysplastic Nevus Syndrome', 'Acquired Immunodeficiency Syndrome-identify-HIV Infections', 'Cerebral Infarction-classified-Atherosclerosis', 'Cerebral Infarction-classified-Cardio-Renal Syndrome', 'HIV Infections-studied-Neoplasms', 'Cardio-Renal Syndrome-i-Atherosclerosis', 'Urinary Bladder Neoplasms-based-Hematuria', 'Liver Diseases-characterized-Hypergammaglobulinemia', 'Endometrial Neoplasms-diagnose-Hemorrhage', 'Atherosclerosis-characterize-Cardiovascular Diseases', 'Atherosclerosis-contribute-Calcinosis', 'Atherosclerosis-contribute-Heart Diseases', 'Cardiovascular Diseases-contribute-Calcinosis', 'Cardiovascular Diseases-contribute-Heart Diseases', 'Heart Diseases-contribute-Renal Insufficiency, Chronic', 'Hyperparathyroidism, Secondary-remain-Death', 'Renal Insufficiency, Chronic-associated-Shock, Cardiogenic', 'Shock, Cardiogenic-associated-Renal Insufficiency, Chronic', 'Shock, Cardiogenic-associated-Hypertension', 'Hypertension-associated-Shock, Cardiogenic', 'Shock, Cardiogenic-associated-Dyslipidemias', 'Dyslipidemias-associated-Shock, Cardiogenic', 'Vascular Calcification-linked-Cardiovascular Diseases', 'Kidney Diseases-possess-Neoplasms', 'Loeys-Dietz Syndrome-associated-Aortic Aneurysm', 'Aortic Aneurysm-associated-Loeys-Dietz Syndrome', 'Loeys-Dietz Syndrome-associated-Rupture', 'Rupture-associated-Loeys-Dietz Syndrome', 'Aneurysm-associated-Loeys-Dietz Syndrome', 'Loeys-Dietz Syndrome-associated-Aneurysm', 'Kidney Diseases-reserved-Neoplasms', 'Renal Insufficiency, Chronic-associate-Proteinuria', 'Proteinuria-associate-Renal Insufficiency, Chronic', 'Breast Neoplasms-use-Death', 'Death-assess-von Hippel-Lindau Disease', 'Hypoglycemia-compromise-Diabetes Mellitus, Type 2', 'Dementia-compromise-Diabetes Mellitus, Type 2', 'Hypoglycemia-considered-Dementia', 'Hypoglycemia-considered-Diabetes Mellitus, Type 2', 'Diabetes Mellitus-considered-Dementia', 'Diabetes Mellitus-considered-Diabetes Mellitus, Type 2', 'Diabetes Mellitus-postulated-Inflammation', 'Nerve Degeneration-include-Hypoglycemia', 'Blood Coagulation Disorders, Inherited-include-Hypoglycemia', 'Muscular Dystrophy, Duchenne-address-Muscular Dystrophies', 'Neurologic Manifestations-precede-Autoimmune Diseases', 'Glaucoma-found-Blindness', 'Genetic Diseases, Inborn-characterized-Hypopigmentation', 'Blindness-associated-Vision Disorders', 'Vision Disorders-associated-Blindness', 'Genetic Diseases, Inborn-characterized-Cardiomyopathies', 'Blindness-associated-Glaucoma', 'Glaucoma-associated-Blindness', 'Blindness-associated-Ocular Hypertension', 'Ocular Hypertension-associated-Blindness', 'Mastocytosis, Systemic-lead-Neoplasms', 'Fibrosis-found-Liver Diseases, Alcoholic', 'Carcinoma, Hepatocellular-occur-Liver Cirrhosis, Alcoholic', 'Carcinoma, Hepatocellular-develop-Liver Cirrhosis, Alcoholic', 'Liver Cirrhosis-occur-Liver Cirrhosis, Alcoholic', 'Carcinoma, Hepatocellular-co-infected-Hepatitis B', 'Carcinoma, Hepatocellular-occur-Alcoholism', 'Carcinoma, Hepatocellular-occur-Death', 'Fatty Liver-include-Liver Diseases, Alcoholic', 'Fibrosis-include-Liver Diseases, Alcoholic', 'Liver Cirrhosis, Alcoholic-include-Liver Diseases, Alcoholic', 'Carcinoma, Hepatocellular-include-Liver Diseases, Alcoholic', 'Hepatitis B-include-Liver Diseases, Alcoholic', 'Arbovirus Infections-include-Liver Diseases, Alcoholic', 'Multiple Myeloma-occur-Renal Insufficiency, Chronic', 'Alcoholism-occur-Death', 'Anemia-indicate-Multiple Myeloma', 'Pain-indicate-Multiple Myeloma', 'Hypercalcemia-indicate-Multiple Myeloma', 'Nerve Degeneration-alter-Epilepsy', 'Carcinoma, Neuroendocrine-suffer-Fatigue', 'Carcinoma, Neuroendocrine-suffer-Muscular Diseases', 'Heart Failure-generate-Mitral Valve Insufficiency', 'Heart Failure-treated-Mitral Valve Insufficiency', 'Infections-cause-Cardiovascular Diseases', 'Liver Cirrhosis-become-Death', 'Liver Cirrhosis-become-Cystic Fibrosis', 'Cystic Fibrosis-become-Liver Cirrhosis', 'Cystic Fibrosis-become-Death', 'Pain-compare-Multiple Myeloma', 'Pain-compare-Peripheral Nervous System Diseases', 'Chronic Disease-decrease-Fractures, Open', 'Pain-further-Peripheral Nervous System Diseases', 'Neoplasms-associated-Myoma', 'Myoma-associated-Neoplasms', 'Mitochondrial Diseases-initiate-Acidosis', 'Lymphopenia-facilitate-Opportunistic Infections', 'Lymphopenia-associated-Glioma', 'Glioma-associated-Lymphopenia', 'Diabetes Mellitus-persist-Death', 'Lysosomal Storage Diseases-cause-Pulmonary Disease, Chronic Obstructive', 'HIV Infections-see-Death', 'Fever-include-Tuberculosis', 'Weight Loss-include-Tuberculosis', 'Breast Neoplasms-presenting-Neoplasms', 'Neoplasms-presenting-Breast Neoplasms', 'Respiratory Tract Infections-treat-Neoplasms', 'Leukemia-used-Autoimmune Diseases', 'Leukemia, Myeloid, Acute-apply-Autoimmune Diseases', 'Leukemia-exposed-Autoimmune Diseases', 'Autoimmune Diseases-develop-Leukemia', 'Fractures, Bone-decrease-Osteoporosis', 'Neoplasms, Second Primary-diagnosed-Neoplasms', 'Neoplasms, Multiple Primary-associated-Death', 'Death-associated-Neoplasms, Multiple Primary', 'Neoplasms-update-Prostatic Neoplasms', 'Heart Diseases-cause-Coronary Artery Disease', 'Anemia, Hemolytic, Autoimmune-lead-Acute Kidney Injury', 'Heart Diseases-cause-Death, Sudden', 'Pain-report-Cerebral Palsy', 'Obesity-define-Endometrial Neoplasms', 'Joint Diseases-report-Cerebral Palsy', 'Fatigue-report-Cerebral Palsy', 'Hypertension-diagnosed-Dementia', 'Death, Sudden, Cardiac-occur-Heart Failure', 'Obesity-diagnosed-Dementia', 'Basal Ganglia Cerebrovascular Disease-associated-Aneurysm', 'Aneurysm-associated-Basal Ganglia Cerebrovascular Disease', 'Basal Ganglia Cerebrovascular Disease-associated-Rupture', 'Rupture-associated-Basal Ganglia Cerebrovascular Disease', 'Basal Ganglia Cerebrovascular Disease-associated-Hemorrhage', 'Hemorrhage-associated-Basal Ganglia Cerebrovascular Disease', 'Neoplasms-become-Pain', 'Dementia-considered-Neoplasms', 'Liver Diseases-range-Liver Cirrhosis, Biliary', 'Liver Diseases-seen-Cystic Fibrosis', 'Fractures, Bone-treated-Osteoporosis', 'Neuromuscular Diseases-experience-Cough', 'Neoplasms-induce-Adenomatous Polyposis Coli', 'Fasciculation-show-Death', 'Renal Insufficiency-increase-Neoplasms', 'Pituitary Neoplasms-include-Acromegaly', 'Anaphylaxis-exceed-Infarction', 'Anaphylaxis-exceed-Heart Failure', 'Neoplasms-combined-Infertility, Male', 'Neoplasms-treat-Infertility, Male', 'Neoplasms-identified-Carcinogenesis', 'Inflammatory Bowel Diseases--are-Neoplasms', 'Crohn Disease--are-Neoplasms', 'Colitis, Ulcerative--are-Neoplasms', 'Dyspnea-achieved-Pleural Diseases', 'HIV Infections-promote-Diabetes Mellitus', 'HIV Infections-promote-Hyperlipidemias', 'Death-raised-Coronary Artery Disease', 'Atherosclerosis-directed-Diabetes Mellitus', 'Diabetes Mellitus-found-Vitreous Hemorrhage', 'Respiratory Tract Infections-account-Pulmonary Disease, Chronic Obstructive', 'Respiratory Tract Infections-account-Wounds and Injuries', 'Respiratory Tract Infections-account-Gastroenteritis', 'Acquired Immunodeficiency Syndrome-involve-Neoplasms', 'Hypertension, Pulmonary-control-Polycythemia', 'Drug-Related Side Effects and Adverse Reactions-administered-Breast Neoplasms', 'Neoplasms-observed-Fever', 'Neoplasms-observed-Hand-Foot Syndrome', 'Agranulocytosis-observed-Fever', 'Agranulocytosis-observed-Hand-Foot Syndrome', 'Fabry Disease-form-Liver Diseases', 'Cardiac Output, Low-decrease-Dermatitis, Atopic', 'Cystic Fibrosis-lead-Bacterial Infections', 'Neoplasms-characterize-Insulinoma', 'Neoplasms-used-Lung Neoplasms', 'Arthritis, Rheumatoid-found-Death', 'Amyloidosis-found-Death', 'Spinal Injuries-found-Death', 'Pulmonary Fibrosis-found-Death', 'Pancreatic Neoplasms-develop-Hodgkin Disease', 'Death-predict-Cystic Fibrosis', 'Chemical and Drug Induced Liver Injury-develop-Fibrosis', 'Carcinoma, Non-Small-Cell Lung-associated-Drug-Related Side Effects and Adverse Reactions', 'Drug-Related Side Effects and Adverse Reactions-associated-Carcinoma, Non-Small-Cell Lung', 'Hepatitis-develop-Fibrosis', 'Death-increase-Digestive System Neoplasms', 'Leukemia-observed-Neoplasms', 'Constriction, Pathologic-increase-Aneurysm', 'Constriction, Pathologic-harbour-Aneurysm', 'Esophageal Neoplasms-noted-Drug-Related Side Effects and Adverse Reactions', 'Hernias, Diaphragmatic, Congenital-included-Pneumonia', 'Kidney Diseases, Cystic-suggest-Hernias, Diaphragmatic, Congenital', 'Death-identified-Angina Pectoris', 'Death-identified-Peripheral Vascular Diseases', 'Death-identified-Hypertension', 'Arthritis, Rheumatoid-investigated-Musculoskeletal Pain', 'Death-include-Carotid Stenosis', 'Cerebrovascular Disorders-compare-Death', 'Death-compared-Constriction, Pathologic', 'Polycythemia Vera-observed-Primary Myelofibrosis', 'Neoplasms-improve-Adenomatous Polyposis Coli', 'Neoplasm Metastasis-undergo-Neoplasms', 'Neoplasm Metastasis-palliate-Neoplasms', 'Death-related-Arbovirus Infections', 'Bone Neoplasms-lead-Death', 'Bone Neoplasms-required-Neoplasms', 'Carcinoma-suffer-Dyspnea', 'Carcinoma-suffer-Neoplasms', 'Dyspnea-caused-Neoplasms', 'Neoplasms-ensured-Neoplasm Metastasis', 'Immunologic Deficiency Syndromes-induce-Neutropenia', 'Immunologic Deficiency Syndromes-induce-Anemia', 'Neoplasm Metastasis-find-Neoplasms', 'Mitral Valve Insufficiency-result-Aortic Valve Insufficiency', 'Mitral Valve Insufficiency-result-Aneurysm', 'Inflammation-prevent-Joint Diseases', 'Parkinson Disease-treated-Death', 'Alzheimer Disease-treated-Death', 'Death-use-Diabetes Mellitus, Type 2', 'Death-estimate-Diabetes Mellitus, Type 2', 'Breast Neoplasms-infiltrated-Neoplasms', 'Heart Failure-associated-Multiple Organ Failure', 'Multiple Organ Failure-associated-Heart Failure', 'Pain-address-Wounds and Injuries', 'Fractures, Bone-start-Osteoporosis', 'Dementia-start-Osteoporosis', 'Muscular Dystrophy, Duchenne-use-Fractures, Bone', 'Muscular Dystrophy, Duchenne-use-Death', 'Fractures, Bone-use-Death', 'Muscular Dystrophy, Duchenne-fall-Fractures, Bone', 'Hemophilia A-include-Hypertension', 'Hemophilia A-include-Diabetes Mellitus', 'Hypertension-modulate-Diabetes Mellitus', 'Osteoporosis-enhanced-Fractures, Bone', 'Genetic Diseases, Inborn-result-Muscular Atrophy', 'Death-deceased-Heart Arrest', 'Neoplasms-associate-Plaque, Amyloid', 'Plaque, Amyloid-associate-Neoplasms', 'Neoplasms-associate-Cerebral Amyloid Angiopathy', 'Cerebral Amyloid Angiopathy-associate-Neoplasms', 'Neurotoxicity Syndromes-treat-Tauopathies', 'Sotos Syndrome-prevent-Ataxia', 'Diabetes Mellitus, Type 2-deserve-Heart Failure', 'Diabetes Mellitus, Type 2-represent-Death', 'Diabetes Mellitus, Type 2-show-Death', 'Cardiomyopathies-study-Heart Failure', 'Ventricular Dysfunction, Left-detected-Diabetes Mellitus', 'Hypotension-detected-Diabetes Mellitus', 'Prader-Willi Syndrome-indicate-Death', 'Prader-Willi Syndrome-indicate-Obesity', 'Hyperphagia-associate-Stomach Rupture', 'Stomach Rupture-associate-Hyperphagia', 'Hyperphagia-choke-Stomach Rupture', 'Hyperphagia-associate-Respiratory Tract Diseases', 'Respiratory Tract Diseases-associate-Hyperphagia', 'Hyperphagia-choke-Respiratory Tract Diseases', 'Obesity-choke-Stomach Rupture', 'Prader-Willi Syndrome-establish-Obesity', 'Obesity-choke-Respiratory Tract Diseases', 'Stomach Rupture-choke-Respiratory Tract Diseases', 'Death-related-Prader-Willi Syndrome', 'Death-related-Hyperphagia', 'Glioma-investigate-Neoplasms', 'Anemia, Sickle Cell-develop-Obesity', 'Anemia, Sickle Cell-develop-Diabetes Mellitus', 'Anemia, Sickle Cell-associated-Obesity', 'Obesity-associated-Anemia, Sickle Cell', 'Obesity-related-Dysbiosis', 'Obesity-remain-Dysbiosis', 'Anemia, Sickle Cell-remain-Dysbiosis', 'Abdominal Pain-manifest-Pneumoperitoneum', 'Fractures, Bone-related-Kidney Failure, Chronic', 'Vascular Calcification-include-Inflammation', 'Inflammation-prevent-Vascular Calcification', 'Heart Failure-caused-Cardiovascular Diseases', 'Cardiovascular Diseases-caused-Heart Failure', 'Cardiovascular Diseases-caused-Arrhythmias, Cardiac', 'Coronary Artery Disease-develop-Heart Failure', 'Prostatic Neoplasms-inhibit-Neoplasm Metastasis', 'Ischemia-result-Multiple Organ Failure', 'Ischemia-prevent-Reperfusion Injury', 'Ischemia-reduce-Multiple Organ Failure', 'Infections-require-Death', 'Neoplasms-exceeded-Heart Diseases', 'Death-exceeded-Heart Diseases', 'Fibrosis-develop-Ascites', 'Liver Diseases-develop-Ascites', 'Craniocerebral Trauma-associated-Pneumonia', 'Pneumonia-associated-Craniocerebral Trauma', 'Rupture-diagnosed-Intracranial Aneurysm', 'Carcinoma, Hepatocellular-impose-Death', 'Carcinoma, Hepatocellular-related-Fibrosis', 'Urinary Incontinence-experience-Pain', 'Nephrotic Syndrome-followed-Renal Insufficiency', 'Diabetes Mellitus-differentiate-Kidney Diseases', 'Diabetes Mellitus-differentiate-Retinal Diseases', 'Retinal Diseases-differentiate-Kidney Diseases', 'Heart Valve Diseases-carry-Death', 'Diabetes Mellitus-suspected-Kidney Diseases', 'Neoplasms-isolated-Multiple Myeloma', 'Cardiotoxicity-show-Neuromuscular Diseases', 'Multiple Myeloma-treated-Drug-Related Side Effects and Adverse Reactions', 'Hypertension-pressurize-Ovarian Diseases', 'Hypertension-pressurize-Colorectal Neoplasms', 'Telangiectasia, Hereditary Hemorrhagic-associated-Stroke', 'Stroke-associated-Telangiectasia, Hereditary Hemorrhagic', 'Telangiectasia, Hereditary Hemorrhagic-associated-Gastrointestinal Hemorrhage', 'Gastrointestinal Hemorrhage-associated-Telangiectasia, Hereditary Hemorrhagic', 'Telangiectasia, Hereditary Hemorrhagic-associated-Hypertension, Pulmonary', 'Hypertension, Pulmonary-associated-Telangiectasia, Hereditary Hemorrhagic', 'Cardiomyopathy, Hypertrophic-include-Hypotension', 'Cardiomyopathy, Hypertrophic-include-Ischemia', 'Cardiomyopathy, Hypertrophic-characterized-Heart Diseases', 'Hypotension-characterized-Heart Diseases', 'Airway Obstruction-characterized-Heart Diseases', 'Ischemia-characterized-Heart Diseases', 'Atrial Fibrillation-characterized-Heart Diseases', 'Death-eliminate-Stomach Neoplasms', 'Cystic Fibrosis-associated-Lung Injury', 'Lung Injury-associated-Cystic Fibrosis', 'Cystic Fibrosis-associated-Malabsorption Syndromes', 'Malabsorption Syndromes-associated-Cystic Fibrosis', 'Cystic Fibrosis-associated-Malnutrition', 'Malnutrition-associated-Cystic Fibrosis', 'Cystic Fibrosis-associated-Exocrine Pancreatic Insufficiency', 'Exocrine Pancreatic Insufficiency-associated-Cystic Fibrosis', 'Genetic Diseases, Inborn-associated-Lung Injury', 'Lung Injury-associated-Genetic Diseases, Inborn', 'Genetic Diseases, Inborn-associated-Malabsorption Syndromes', 'Malabsorption Syndromes-associated-Genetic Diseases, Inborn', 'Genetic Diseases, Inborn-associated-Malnutrition', 'Malnutrition-associated-Genetic Diseases, Inborn', 'Genetic Diseases, Inborn-associated-Exocrine Pancreatic Insufficiency', 'Exocrine Pancreatic Insufficiency-associated-Genetic Diseases, Inborn', 'Genetic Diseases, Inborn-associated-Respiratory Insufficiency', 'Respiratory Insufficiency-associated-Genetic Diseases, Inborn', 'Hypogonadism-lead-Metabolic Syndrome', 'Hypogonadism-lead-Diabetes Mellitus', 'Hypogonadism-lead-Cardiovascular Diseases', 'Neoplasms-seen-Breast Neoplasms', 'Anemia, Sickle Cell-caused-Hemoglobinopathies', 'Anemia, Sickle Cell-devastate-Hemolysis', 'Hemoglobinopathies-result-Hemolysis', 'Cardiomyopathies-lead-Death, Sudden', 'Death-result-Cerebrovascular Disorders', 'HIV Infections-result-Coinfection', 'Wiskott-Aldrich Syndrome-characterised-Thrombocytopenia', 'Wiskott-Aldrich Syndrome-characterised-Eczema', 'Wiskott-Aldrich Syndrome-develop-Neoplasms', 'X-Linked Combined Immunodeficiency Diseases-characterised-Thrombocytopenia', 'X-Linked Combined Immunodeficiency Diseases-characterised-Eczema', 'X-Linked Combined Immunodeficiency Diseases-develop-Neoplasms', 'Thrombocytopenia-develop-Neoplasms', 'Eczema-develop-Neoplasms', 'Tuberculosis-live-HIV Infections', 'Drug-Related Side Effects and Adverse Reactions-improve-HIV Infections', 'Acromegaly-result-Headache', 'Acromegaly-result-Fatigue', 'Acromegaly-result-Arthralgia', 'Acromegaly-result-Sexual Dysfunction, Physiological', 'Acromegaly-result-Hyperhidrosis', 'Sarcopenia-associated-Cachexia', 'Cachexia-associated-Sarcopenia', 'Acromegaly-result-Diabetes Mellitus', 'Acromegaly-result-Hypertension', 'Acromegaly-result-Neoplasms', 'Sarcopenia-associated-Autoimmune Diseases', 'Autoimmune Diseases-associated-Sarcopenia', 'Mitochondrial Encephalomyopathies-characterized-Gastrointestinal Diseases', 'Mitochondrial Encephalomyopathies-characterized-Nervous System Diseases', 'Mitochondrial Encephalomyopathies-show-Death', 'Drug-Related Side Effects and Adverse Reactions-limited-Nausea', 'Drug-Related Side Effects and Adverse Reactions-limited-Vomiting', 'Joint Diseases-associated-Atherosclerosis', 'Atherosclerosis-associated-Joint Diseases', 'Autoimmune Diseases-associated-Atherosclerosis', 'Atherosclerosis-associated-Autoimmune Diseases', 'Polycystic Kidney Diseases-defined-Kidney Diseases', 'Polycystic Kidney Diseases-defined-Chemical and Drug Induced Liver Injury', 'Genetic Diseases, Inborn-defined-Kidney Diseases', 'Genetic Diseases, Inborn-defined-Chemical and Drug Induced Liver Injury', 'HIV Infections-result-Renal Insufficiency', 'Neoplasms-related-Sarcoma, Kaposi', 'Neoplasms-include-Immunologic Deficiency Syndromes', 'Neoplasms-associated-Hydronephrosis', 'Hydronephrosis-associated-Neoplasms', 'Neoplasms-associated-Renal Insufficiency', 'Renal Insufficiency-associated-Neoplasms', 'Neoplasms-associated-Vesicovaginal Fistula', 'Vesicovaginal Fistula-associated-Neoplasms', 'Pain-include-Pancreatitis', 'Stroke-decrease-Brain Injuries, Diffuse', 'Death-increased-Lung Neoplasms', 'Multiple Sclerosis-observed-Demyelinating Diseases', 'Demyelinating Diseases-used-Multiple Sclerosis', 'Basal Ganglia Diseases-used-Multiple Sclerosis', 'Neoplasms-complicate-Adenoma', 'Adenocarcinoma, Mucinous-complicate-Adenoma', 'Neoplasms-exacerbate-Psychoses, Substance-Induced', 'Pain-happen-Death', 'Neoplasms-use-Pain', 'Carcinoma, Hepatocellular-diagnosed-Cholangiocarcinoma', 'Cholangiocarcinoma-include-Carcinoma, Hepatocellular', 'Death-use-Urinary Bladder Neoplasms', 'Death-use-Drug-Related Side Effects and Adverse Reactions', 'Death-account-Drug-Related Side Effects and Adverse Reactions', 'Papillomavirus Infections-involved-Skin Neoplasms', 'Keratosis, Actinic-considered-Carcinoma, Squamous Cell', 'Neoplasms-observed-Carcinogenesis', 'Hemorrhage-show-Hematoma', 'Death-include-Hypertension, Pulmonary', 'Spinal Cord Injuries-maintain-Respiratory Paralysis', 'Death-include-Neutropenia', 'Renal Insufficiency, Chronic-serve-Pancreatitis, Graft', 'Neoplasms-predispose-Thrombosis', 'Death-related-Anemia', 'Blood Coagulation Disorders-predispose-Thrombosis', 'Neoplasms-linked-Thrombophilia', 'Thrombosis-predispose-Neoplasms', 'Neoplasms-linked-Thrombosis', 'Myelodysplastic Syndromes-provide-Death', 'Communicable Diseases-found-Renal Artery Obstruction', 'Carcinoma, Hepatocellular-make-Drug-Related Side Effects and Adverse Reactions', 'Cystic Fibrosis-inform-Infertility, Female', 'Genu Valgum-implicated-Carcinoma, Squamous Cell', 'Genu Valgum-initiate-Carcinogenesis', 'Carcinoma, Squamous Cell-initiate-Carcinogenesis', 'Nerve Degeneration-attenuate-Paralysis', 'Death-averted-Stroke', 'Ataxia Telangiectasia-characterized-Lymphoma', 'Ataxia Telangiectasia-characterized-Neurologic Manifestations', 'Thrombocythemia, Essential-carry-Thromboembolism', 'Thrombocythemia, Essential-carry-Hemorrhage', 'Lymphoma-decrease-Neoplasms', 'Esophageal Neoplasms-compromise-Blood Coagulation Disorders', 'Cystic Fibrosis-recognised-Amyloidosis', 'Hemorrhage-include-Amyloidosis', 'Deglutition Disorders-followed-Head and Neck Neoplasms', 'Thrombosis-include-Amyloidosis', 'Aneurysm-offer-Hypertension', 'Ischemia-cause-Necrosis', 'Diabetes Mellitus-include-Renal Insufficiency', 'Esophageal Neoplasms-result-Deglutition Disorders', 'Neoplasms-found-Acquired Immunodeficiency Syndrome', 'Neoplasms-report-Esophageal Squamous Cell Carcinoma', 'Acquired Immunodeficiency Syndrome-diagnosed-Esophageal Squamous Cell Carcinoma', 'Spinal Dysraphism-affect-Pain', 'Spinal Dysraphism-result-Neurologic Manifestations', 'Hypoxia-associated-Wounds and Injuries', 'Wounds and Injuries-associated-Hypoxia', 'Wounds and Injuries-reflect-Cardiovascular Diseases', 'Cardiovascular Diseases-reflect-Inflammation', 'Wounds and Injuries-reflect-Inflammation', 'Wounds and Injuries-precipitated-Hypertension', 'Wounds and Injuries-limit-Hemorrhage', 'Wounds and Injuries-precipitated-Diabetes Mellitus', 'Wounds and Injuries-precipitated-Dyslipidemias', 'Heart Failure-seen-Wounds and Injuries', 'Wounds and Injuries-initiate-Inflammation', 'Wounds and Injuries-associated-Heart Failure', 'Heart Failure-associated-Wounds and Injuries', 'Inflammation-result-Wounds and Injuries', 'Wounds and Injuries-portend-Cardiovascular Diseases', 'Hemangioendothelioma, Epithelioid-known-Disseminated Intravascular Coagulation', 'Heart Diseases-allograft-Death', 'Arthritis, Rheumatoid-shared-Joint Diseases', 'Carcinoma, Small Cell-associated-Fibrosis', 'Fibrosis-associated-Carcinoma, Small Cell', 'Lung Neoplasms-occur-Asbestosis', 'Death-follow-Melanoma', 'Osteoarthritis, Hip-associated-Femoral Neck Fractures', 'Femoral Neck Fractures-associated-Osteoarthritis, Hip', 'Acquired Immunodeficiency Syndrome-associated-Dyslipidemias', 'Dyslipidemias-associated-Acquired Immunodeficiency Syndrome', 'Acquired Immunodeficiency Syndrome-associated-Atherosclerosis', 'Atherosclerosis-associated-Acquired Immunodeficiency Syndrome', 'Insulin Resistance-associated-Dyslipidemias', 'Dyslipidemias-associated-Insulin Resistance', 'Diabetes Mellitus-influence-Atherosclerosis', 'Muscular Diseases-attenuate-Dyspnea', 'Muscular Diseases-decrease-Fatigue', 'Heart Failure-attenuate-Dyspnea', 'Heart Failure-decrease-Fatigue', 'Dyspnea-decrease-Fatigue', 'Cardiac Output, High-decrease-Cardiac Output, Low', 'Cardiac Output, High-redistributed-Fatigue', 'Hemorrhage-compare-Stroke', 'Infections-modify-Peptic Ulcer', 'Hematologic Diseases-increase-Drug Hypersensitivity', 'Renal Insufficiency-induce-Immunologic Deficiency Syndromes', 'Death-produce-Cerebrovascular Disorders', 'Death-produce-Pulmonary Disease, Chronic Obstructive', 'Erythromelalgia-focus-Thrombocythemia, Essential', 'Death-produce-Diabetes Mellitus', 'Cardiovascular Diseases-reduce-Marfan Syndrome', 'Aortic Aneurysm-reduce-Marfan Syndrome', 'Arbovirus Infections-move-Death', 'HIV Infections-move-Death', 'Ascites-include-Death', 'Liver Cirrhosis, Biliary-include-Death', 'Hypotension-include-Death', 'Spinal Cord Injuries-cover-Fever', 'Spinal Cord Injuries-cover-Nervous System Diseases', 'Spinal Cord Injuries-cover-Infections', 'Spinal Cord Injuries-cover-Venous Thrombosis', 'Spinal Cord Injuries-transfer-Lung Diseases', 'Neurologic Manifestations-contribute-Apnea', 'Sleep Wake Disorders-include-Sleep Apnea Syndromes', 'Arthritis, Rheumatoid-influenced-Death', 'Obesity-reduce-Neoplasms', 'Neoplasms-protect-Cardiovascular Diseases', 'Sleep Apnea, Obstructive-found-Obesity', 'Neoplasms-cure-Death', 'Neoplasms-define-Death', 'Adenoma-contain-Neoplasm Invasiveness', 'Obesity Hypoventilation Syndrome-found-Sleep Apnea, Obstructive', 'Neoplasm Metastasis-resected-Death', 'Colorectal Neoplasms-resected-Death', 'Jaundice-treat-Neoplasms', 'Eye Diseases-detected-Constriction, Pathologic', 'Neurologic Manifestations-increase-Death', 'Gallstones-cause-Pain', 'Gallstones-occur-Death', 'Pain-occur-Cholecystitis, Acute', 'Pain-occur-Pancreatitis', 'Cystic Fibrosis-become-Communicable Diseases', 'Kidney Papillary Necrosis-supervene-Renal Insufficiency', 'Malaria-result-Infections', 'Coronary Artery Disease-seen-Hypertension', 'Hypertension-found-Kidney Diseases', 'Adenocarcinoma, Mucinous-biopsied-Edema', 'Adenocarcinoma, Mucinous-biopsied-Cutaneous Fistula', 'Periodontal Diseases-prevent-Dementia', 'Spinal Cord Diseases-followed-Fractures, Bone', 'Eunuchism-present-Erectile Dysfunction', 'Metabolic Diseases-impair-Bone Neoplasms', 'Fever-reduce-Pain', 'Fever-reduce-Neoplasm Metastasis', 'Turner Syndrome-seem-Hearing Loss, Central', 'Hodgkin Disease-seem-Hearing Loss, Central', 'Pseudomyxoma Peritonei-caused-Neoplasms', 'Seminoma-associate-Neoplasms', 'Neoplasms-associate-Seminoma', 'Lymphoma, T-Cell-represent-Parkinson Disease', 'Lymphoma, T-Cell-affected-Neoplasms', 'Parkinson Disease-affected-Neoplasms', 'Nervous System Diseases-develop-Parkinson Disease', 'Cardiovascular Diseases-expect-Heart Failure', 'Cardiovascular Diseases-associate-Death', 'Death-associate-Cardiovascular Diseases', 'Sleep Wake Disorders-associate-Death', 'Death-associate-Sleep Wake Disorders', 'Anemia, Hemolytic-cause-Death', 'Sleep Wake Disorders-influence-Cardiovascular Diseases', 'Crystal Arthropathies-known-Cataract', 'Neoplasms-increase-Encephalitis, California', 'Bone Diseases-associated-Hyperparathyroidism, Secondary', 'Hyperparathyroidism, Secondary-associated-Bone Diseases', 'Cystic Fibrosis-include-Exocrine Pancreatic Insufficiency', 'Cystic Fibrosis-include-Malabsorption Syndromes', 'Cystic Fibrosis-differentiated-Short Bowel Syndrome', 'Diabetic Nephropathies-affect-Diabetes Mellitus', 'Death-represented-Respiratory Insufficiency', 'Death-occur-Atrophy', 'Death-occur-Neurodegenerative Diseases', 'Respiratory Insufficiency-represented-Atrophy', 'Respiratory Insufficiency-represented-Neurodegenerative Diseases', 'Wolfram Syndrome-study-Death', 'Autoimmune Diseases-suggest-Immune System Diseases', 'Inflammation-suggest-Immune System Diseases', 'Neoplasms-multiply-Death', 'Neurologic Manifestations-associated-Landau-Kleffner Syndrome', 'Landau-Kleffner Syndrome-associated-Neurologic Manifestations', 'Epilepsy-increase-Seizures', 'Eclampsia-associate-Lupus Erythematosus, Systemic', 'Lupus Erythematosus, Systemic-associate-Eclampsia', 'Blindness-associate-Lupus Erythematosus, Systemic', 'Lupus Erythematosus, Systemic-associate-Blindness', 'Cystic Fibrosis-claim-Death', 'Cystic Fibrosis-claim-Bacterial Infections', 'Cystic Fibrosis-claim-Inflammation', 'Cystic Fibrosis-claim-Airway Obstruction', 'Stroke-associate-Lupus Erythematosus, Systemic', 'Lupus Erythematosus, Systemic-associate-Stroke', 'Headache-associate-Lupus Erythematosus, Systemic', 'Lupus Erythematosus, Systemic-associate-Headache', 'Stomach Neoplasms-assessedus-Death', 'Vision Disorders-associate-Lupus Erythematosus, Systemic', 'Lupus Erythematosus, Systemic-associate-Vision Disorders', 'Neoplasms-cause-Primary Ovarian Insufficiency', 'Ovarian Neoplasms-cause-Primary Ovarian Insufficiency', 'Neoplasms-range-Primary Ovarian Insufficiency', 'Disseminated Intravascular Coagulation-associate-Lupus Erythematosus, Systemic', 'Lupus Erythematosus, Systemic-associate-Disseminated Intravascular Coagulation', 'Hemolysis-associate-Lupus Erythematosus, Systemic', 'Lupus Erythematosus, Systemic-associate-Hemolysis', 'Neurologic Manifestations-associate-Lupus Erythematosus, Systemic', 'Lupus Erythematosus, Systemic-associate-Neurologic Manifestations', 'Gonadal Disorders-cause-Neoplasms', 'Stillbirth-associate-Lupus Erythematosus, Systemic', 'Lupus Erythematosus, Systemic-associate-Stillbirth', 'Obesity-associate-Lupus Erythematosus, Systemic', 'Lupus Erythematosus, Systemic-associate-Obesity', 'Hyperglycemia-associate-Lupus Erythematosus, Systemic', 'Lupus Erythematosus, Systemic-associate-Hyperglycemia', 'Hypertension-associate-Lupus Erythematosus, Systemic', 'Lupus Erythematosus, Systemic-associate-Hypertension', 'Kidney Diseases-associate-Lupus Erythematosus, Systemic', 'Lupus Erythematosus, Systemic-associate-Kidney Diseases', 'Autoimmune Diseases-associate-Lupus Erythematosus, Systemic', 'Lupus Erythematosus, Systemic-associate-Autoimmune Diseases', 'Lupus Erythematosus, Systemic-associate-Antiphospholipid Syndrome', 'Antiphospholipid Syndrome-associate-Lupus Erythematosus, Systemic', 'Adenoma-necessitate-Chiari-Frommel Syndrome', 'Anemia, Sickle Cell-associated-Stroke', 'Stroke-associated-Anemia, Sickle Cell', 'Anemia, Sickle Cell-associated-Acute Chest Syndrome', 'Acute Chest Syndrome-associated-Anemia, Sickle Cell', 'Anemia, Sickle Cell-associated-Osteonecrosis', 'Osteonecrosis-associated-Anemia, Sickle Cell', 'Anemia, Sickle Cell-associated-Kidney Diseases', 'Kidney Diseases-associated-Anemia, Sickle Cell', 'Arthritis, Rheumatoid-characterized-Musculoskeletal Diseases', 'Anemia, Sickle Cell-associated-Retinal Diseases', 'Retinal Diseases-associated-Anemia, Sickle Cell', 'Achondroplasia-develop-Osteoarthritis', 'Carcinoma, Hepatocellular-interrupt-Mastoiditis', 'Heart Failure-present-Obesity', 'Heart Failure-present-Anemia', 'Heart Failure-present-Lung Diseases', 'Heart Failure-present-Diabetes Mellitus', 'Heart Failure-present-Neoplasms', 'Heart Failure-present-Dystonia', 'Heart Valve Diseases-develop-Aortic Valve Stenosis', 'Memory Disorders-restore-Alzheimer Disease', 'Hirsutism-associated-Polycystic Ovary Syndrome', 'Polycystic Ovary Syndrome-associated-Hirsutism', 'Death-attributed-Tuberculosis, Pulmonary', 'Weight Loss-result-Polycystic Ovary Syndrome', 'Wounds and Injuries-modulate-Brain Injuries, Traumatic', 'Multiple Myeloma-characterized-Hypercalcemia', 'Communicable Diseases-precipitated-Wounds and Injuries', 'Fractures, Bone-precipitated-Wounds and Injuries', 'Fractures, Bone-decline-Osteogenesis Imperfecta', 'HIV Infections-matched-Infections', 'Neoplasm Metastasis-focus-Lung Neoplasms', 'Stroke-informed-Fatigue', 'Stroke-treat-Fatigue', 'Death-include-Exanthema', 'Death-develop-Exanthema', 'Calcinosis-occur-Metabolic Diseases', 'Thrombocytosis-include-Primary Myelofibrosis', 'Genetic Diseases, Inborn-occur-Metabolic Diseases', 'Diabetes Mellitus, Type 2-increasing-Obesity', 'Bacteremia-change-Death', 'Sepsis-change-Death', 'Fistula-change-Death', 'Death-diagnosed-Heart Failure', 'Dementia-refrain-Death', 'Pancreatitis-performed-Diabetes Mellitus', 'Heart Diseases-present-Arrhythmias, Cardiac', 'Intestinal Diseases-reported-Situs Inversus', 'Hepatitis C-rise-Liver Diseases', 'Hepatitis C-rise-Death', 'Lung Neoplasms-experience-Venous Thromboembolism', 'Neoplasms-worsen-Venous Thromboembolism', 'Thrombosis-worsen-Venous Thromboembolism', 'Lung Neoplasms-identify-Death', 'Thrombosis-halt-Neoplasms', 'Venous Thromboembolism-identify-Death', 'Cystic Fibrosis-experience-Respiratory Tract Infections', 'Cystic Fibrosis-recorded-Death', 'Vulvar Diseases-immunostain-Papillomavirus Infections', 'Vulvar Diseases-associated-Neoplasms', 'Neoplasms-associated-Vulvar Diseases', 'Lichen Sclerosus et Atrophicus-considered-Vulvar Neoplasms', 'Leg Ulcer-combined-Otitis', 'Leg Ulcer-combined-Infections', 'Amnesia-grow-Atrophy', 'Brain Injuries-grow-Atrophy', 'Neoplasms-abolish-Prostatic Neoplasms', 'Peritoneal Diseases-lead-Nausea', 'Peritoneal Diseases-lead-Pain', 'Peritoneal Diseases-diagnosed-Ascites', 'Peritoneal Diseases-diagnosed-Short Bowel Syndrome', 'Death-cause-Erectile Dysfunction', 'Death-associated-Mitral Valve Prolapse', 'Mitral Valve Prolapse-associated-Death', 'Death-cause-Chemical and Drug Induced Liver Injury', 'Death-associated-Sleep Apnea Syndromes', 'Sleep Apnea Syndromes-associated-Death', 'Discitis-represent-Osteomyelitis', 'Infections-represent-Osteomyelitis', 'Infections-receive-Communicable Diseases', 'Back Pain-followed-Fever', 'HIV Infections-increase-Neoplasms', 'HIV Infections-increase-Lymphoma, Non-Hodgkin', 'HIV Infections-decline-Sarcoma, Kaposi', 'Hyperglycemia-alter-Bone Neoplasms', 'Fractures, Bone-induced-Diabetes Mellitus', 'Tremor-remain-Death', 'Neoplasms-mediated-Carcinogenesis', 'Carcinoma, Hepatocellular-make-Neoplasms', 'Carcinoma, Hepatocellular-make-Fibrosis', 'Neoplasms-make-Fibrosis', 'Hemoglobinuria, Paroxysmal-lead-Anemia', 'Myelodysplastic Syndromes-lead-Anemia', 'Hypertension-linked-Stroke', 'Death-attributed-Lung Neoplasms', 'Death-follow-Parkinson Disease', 'Bronchopneumonia-account-Coronary Artery Disease', 'Bronchopneumonia-account-Neoplasms', 'Bronchopneumonia-account-Death', 'Constriction, Pathologic-cause-Cerebral Infarction', 'Dwarfism, Pituitary-reduced-Cardiovascular Diseases', 'Neurologic Manifestations-correlated-Coronary Artery Disease', 'Obesity-accelerate-Death', 'Acromegaly-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-Acromegaly', 'Dwarfism, Pituitary-reverse-Cardiovascular Diseases', 'Acromegaly-show-Cardiovascular Diseases', 'Aortic Aneurysm, Abdominal-gain-Death', 'Osteochondroma-cause-Pain', 'Chondrosarcoma-performed-Neoplasms', 'Chondrosarcoma-performed-Bone Neoplasms', 'Osteochondroma-examined-Chondrosarcoma', 'Diabetes Mellitus, Type 2-affect-Diabetes Mellitus', 'HIV Infections-apply-Colorectal Neoplasms', 'Heart Failure-apply-Colorectal Neoplasms', 'Fibrosis-derived-Liver Diseases', 'Fibrosis-derived-Hepatitis B', 'Carcinoma, Hepatocellular-derived-Liver Diseases', 'Carcinoma, Hepatocellular-derived-Hepatitis B', 'Carcinoma, Hepatocellular-applied-Hepatitis B', 'Diabetes Mellitus-display-Fractures, Bone', 'Diabetes Mellitus-display-Muscular Dystrophy, Duchenne', 'Fractures, Bone-display-Muscular Dystrophy, Duchenne', 'Muscular Dystrophy, Duchenne-prevent-Osteoporotic Fractures', 'Muscular Dystrophy, Duchenne-prevent-Diabetes Mellitus', 'Osteoporotic Fractures-prevent-Diabetes Mellitus', 'Intellectual Disability-caused-Congenital Hypothyroidism', 'Intellectual Disability-prevented-Genetic Diseases, Inborn', 'Cystic Fibrosis-planned-Hemoglobinopathies', 'Ischemia-disclose-Hypoxia', 'Obesity-accomplish-Weight Loss', 'Parkinson Disease-result-Neurodegenerative Diseases', 'Death-seen-Cholecystitis, Acute', 'Neoplasms-arise-Nephrosis, Lipoid', 'Diabetes Mellitus-associated-Musculoskeletal Diseases', 'Musculoskeletal Diseases-associated-Diabetes Mellitus', 'Meningeal Neoplasms-suffer-Coinfection', 'Neurilemmoma-suffer-Coinfection', 'Pituitary Neoplasms-suffer-Coinfection', 'Neoplasms-mimic-Optic Neuritis', 'Ventricular Dysfunction-reduced-Death', 'Ovarian Neoplasms-lost-Pulmonary Atresia', 'Fever-occur-Heart Valve Diseases', 'Heart Failure-treat-Myocardial Infarction', 'Lung Neoplasms-show-Melanoma', 'Adenocarcinoma-arise-Esophageal Neoplasms', 'Hemochromatosis-look-Liver Diseases', 'Breast Neoplasms-reduce-Cataract', 'Cardiomyopathy, Dilated-protect-Aneurysm', 'Blindness-prevent-Diabetes Mellitus', 'Death-admitted-Spinal Injuries', 'Death-contribute-Heart Diseases', 'Death-contribute-Intracranial Hemorrhages', 'Death-contribute-Chemical and Drug Induced Liver Injury', 'Death-calculated-Spinal Cord Injuries', 'Stomach Neoplasms-include-Adenocarcinoma', 'Colorectal Neoplasms-include-Adenocarcinoma', 'Dwarfism, Pituitary-include-Cardiovascular Diseases', 'Xerostomia-present-Sialadenitis', 'Xerostomia-suffer-Osteoarthritis', 'Sialadenitis-suffer-Osteoarthritis', 'Coronary Artery Disease-reported-Death', 'Polycythemia Vera-share-Myeloproliferative Disorders', 'Hemochromatosis-associated-Fibrosis', 'Fibrosis-associated-Hemochromatosis', 'Sepsis-included-Infections', 'Pneumonia-occur-Acquired Immunodeficiency Syndrome', 'Pneumonia-develop-Acquired Immunodeficiency Syndrome', 'Pneumonia-develop-AIDS Dementia Complex', 'Acquired Immunodeficiency Syndrome-develop-AIDS Dementia Complex', 'HIV Infections-develop-Pneumocystis Infections', 'Amyotrophic Lateral Sclerosis-rose-Death', 'Shock-determined-Death', 'Spinal Cord Injuries-estimated-Death', 'Scoliosis-associated-Abnormalities, Drug-Induced', 'Abnormalities, Drug-Induced-associated-Scoliosis', 'Liver Diseases-characterized-Cholestasis, Intrahepatic', 'Diabetic Nephropathies-shortened-Diabetes Mellitus', 'Genetic Diseases, Inborn-characterised-Papillomavirus Infections', 'Pruritus-increase-Pigmentation Disorders', 'Genetic Diseases, Inborn-characterised-Carcinoma, Squamous Cell', 'Pruritus-present-Jaundice', 'Genetic Diseases, Inborn-manage-Neoplasm Metastasis', 'Pigmentation Disorders-present-Jaundice', 'Genetic Diseases, Inborn-characterised-Skin Neoplasms', 'Retinal Diseases-contribute-Diabetes Mellitus', 'Immune System Diseases-appear-Autoimmune Diseases', 'Breast Neoplasms-reduced-Death', 'Breast Neoplasms-reduced-Coronary Artery Disease', 'Coronary Artery Disease-detect-Hip Fractures', 'Neoplasms-established-Melanoma', 'Neoplasms-established-Neuroblastoma', 'Neoplasms-established-Leiomyosarcoma', 'Bone Neoplasms-criticized-Death', 'Diabetes Insipidus-known-Wolfram Syndrome', 'Diabetes Mellitus-known-Wolfram Syndrome', 'Optic Atrophy-known-Wolfram Syndrome', 'Death-induced-Seizures', 'Deafness-known-Wolfram Syndrome', 'Seizures-identified-Death', 'Death-cause-Hypoxia', 'Seizures-lead-Hypoxia', 'Seizures-occur-Heart Failure', 'Hypoxia-cause-Heart Failure', 'Neoplasms-start-Polyps', 'Colorectal Neoplasms-start-Polyps', 'Colorectal Neoplasms-diagnosed-Polyps', 'Colorectal Neoplasms-start-Neoplasms', 'Neoplasms-diagnosed-Polyps', 'Stroke-associated-Iatrogenic Disease', 'Iatrogenic Disease-associated-Stroke', 'Genetic Diseases, Inborn-associated-Lupus Erythematosus, Systemic', 'Lupus Erythematosus, Systemic-associated-Genetic Diseases, Inborn', 'Arthritis, Rheumatoid-associated-Fatigue', 'Fatigue-associated-Arthritis, Rheumatoid', 'Respiratory Tract Diseases-cause-Sleep Wake Disorders', 'Sleep Wake Disorders-known-Sleep Initiation and Maintenance Disorders', 'Sleep Wake Disorders-associated-Hypertension, Pulmonary', 'Hypertension, Pulmonary-associated-Sleep Wake Disorders', 'Lung Diseases, Interstitial-associated-Hypertension, Pulmonary', 'Hypertension, Pulmonary-associated-Lung Diseases, Interstitial', 'Hypertension, Pulmonary-underlie-Sleep Wake Disorders', 'Endometrial Neoplasms-become-Obesity', 'Dysautonomia, Familial-impair-Kidney Failure, Chronic', 'Dysautonomia, Familial-impair-Cardiomyopathy, Hypertrophic', 'Dysautonomia, Familial-impair-Arrhythmias, Cardiac', 'Dysautonomia, Familial-impair-Stroke', 'Infarction-play-Nail-Patella Syndrome', 'Leukoencephalopathies-play-Nail-Patella Syndrome', 'Psychoses, Substance-Induced-contribute-Hyperkinesis', 'Death-strengthen-Wounds and Injuries', 'Death-avert-Wounds and Injuries', 'Leukemia, Myeloid, Acute-reduce-Leukemia, Myelomonocytic, Juvenile', 'Leukemia, Myeloid, Acute-perform-Death', 'Acute Disease-malnourished-Malnutrition', 'Language Disorders-indicate-Amnesia', 'Hypoglycemia-include-Metabolic Diseases', 'Abnormalities, Drug-Induced-include-Metabolic Diseases', 'Stillbirth-include-Metabolic Diseases', 'Dysbiosis-worsen-Neurodegenerative Diseases', 'Dysbiosis-worsen-Alzheimer Disease', 'Dysbiosis-shown-Parkinson Disease', 'Wounds and Injuries-report-Heart Arrest', 'Capillary Leak Syndrome-associated-Death', 'Death-associated-Capillary Leak Syndrome', 'Cystic Fibrosis-avoid-Cough', 'Cystic Fibrosis-mitigate-Zoonoses', 'Cough-mitigate-Zoonoses', 'Language Development Disorders-range-Quadriplegia', 'Death-treated-Tuberculosis', 'Rhabdomyolysis-triggered-Infections', 'Nocturia-including-Urinary Bladder Neoplasms', 'Diabetes Mellitus-expose-Peripheral Arterial Disease', 'Diabetes Mellitus-expose-Critical Illness', 'Pain-including-Urinary Bladder Neoplasms', 'Diabetes Mellitus-expose-Ulcer', 'Death-vary-Dementia', 'Shock-follow-Myocardial Infarction', 'Death-follow-Shock', 'Diabetes Mellitus, Type 2-estimate-Death', 'Diabetes Mellitus, Type 2-estimate-Heart Failure', 'Diabetes Mellitus, Type 2-estimate-Coronary Artery Disease', 'Diabetes Mellitus, Type 2-estimate-Stroke', 'Diabetes Mellitus, Type 2-estimate-Peripheral Arterial Disease', 'Diabetes Mellitus, Type 2-estimate-Renal Insufficiency, Chronic', 'Hypertension-mitigated-HIV Infections', 'Hyperglycemia-considered-Diabetes Mellitus', 'Scoliosis-carry-Death', 'Inflammation-focus-Ischemia', 'Inflammation-focus-Coronary Artery Disease', 'Ischemia-refer-Death', 'Ischemia-refer-Arthritis, Rheumatoid', 'Coronary Artery Disease-refer-Death', 'Inflammation-focus-Arthritis, Rheumatoid', 'Coronary Artery Disease-refer-Arthritis, Rheumatoid', 'Diabetes Mellitus-undergo-Heart Failure', 'Thalassemia-constitute-Anemia', 'Thalassemia-result-Genetic Diseases, Inborn', 'Anemia-result-Genetic Diseases, Inborn', 'Hematologic Neoplasms-develop-Thalassemia', 'Sepsis-show-Death', 'Neurologic Manifestations-underlie-Neuronal Ceroid-Lipofuscinoses', 'Bile Duct Neoplasms-complicated-Jaundice, Obstructive', 'Lysosomal Storage Diseases-lead-Neurodegenerative Diseases', 'Jaundice-lead-Airway Obstruction', 'Death-reported-Intracranial Hemorrhages', 'Neurotoxicity Syndromes-cause-Neurodegenerative Diseases', 'Brain Diseases-include-Neurodegenerative Diseases', 'Death-occur-Lung Diseases, Interstitial', 'Prostatic Neoplasms-confirm-Neoplasm Metastasis', 'Fractures, Bone-noted-Death', 'Hepatitis C-establish-Infections', 'Hepatitis C-explain-Fibrosis', 'Infections-evolve-Carcinoma, Hepatocellular', 'Fatigue-show-Sleep Deprivation', 'Atrioventricular Block-associated-Death', 'Death-associated-Atrioventricular Block', 'Lung Neoplasms-link-Death', 'Rheumatic Diseases-suppress-Inflammation', 'Rheumatic Diseases-lowering-Cardiovascular Diseases', 'Inflammation-lowering-Cardiovascular Diseases', 'Infections-augment-Neoplasms', 'Atherosclerosis-accompanied-Cardiovascular Diseases', 'Inflammation-proceed-Cardiovascular Diseases', 'Inflammation-proceed-Rheumatic Diseases', 'Inflammation-proceed-Mastocytosis, Systemic', 'Ventricular Remodeling-decrease-Heart Failure', 'Ventricular Remodeling-use-Heart Failure', 'Wolman Disease-thrive-Hepatomegaly', 'Hepatomegaly-thrive-Liver Failure', 'Hypertension, Pulmonary-associated-Cardiac Output, Low', 'Cardiac Output, Low-associated-Hypertension, Pulmonary', 'Hypertension, Pulmonary-decrease-Cardiac Output, Low', 'Hypertension, Pulmonary-occur-Hypoplastic Left Heart Syndrome', 'Ovarian Diseases-associated-Sleep Wake Disorders', 'Sleep Wake Disorders-associated-Ovarian Diseases', 'Sleep Wake Disorders-contribute-Dementia', 'Colorectal Neoplasms-harbor-Adenomatous Polyposis Coli', 'Colorectal Neoplasms-show-Adenomatous Polyposis Coli', 'Adenomatous Polyposis Coli-predominate-Colorectal Neoplasms', 'Adenomatous Polyposis Coli-predominate-Colonic Neoplasms', 'Neurodegenerative Diseases-serve-Spinal Cord Injuries', 'Neurodegenerative Diseases-trigger-Autonomic Dysreflexia', 'Pain-serve-Spinal Cord Injuries', 'Pain-trigger-Autonomic Dysreflexia', 'Osteoarthritis, Hip-cause-Quadriplegia', 'Spinal Cord Injuries-trigger-Autonomic Dysreflexia', 'Quadriplegia-lead-Kidney Calculi', 'Crohn Disease-associated-Infections', 'Infections-associated-Crohn Disease', 'Drug-Related Side Effects and Adverse Reactions-increase-Muscular Atrophy, Spinal', 'Drug-Related Side Effects and Adverse Reactions-relate-Alzheimer Disease', 'Multiple Sclerosis-examined-Death', 'Death-vary-Obesity', 'Obesity-live-Diabetes Mellitus', 'Heart Arrest-induce-Brain Neoplasms', 'Heart Arrest-induce-Neoplasms', 'Heart Arrest-decrease-Neoplasms', 'Brain Neoplasms-decrease-Neoplasms', 'Hearing Loss-refer-Hearing Loss, Central', 'Aneuploidy-develop-Precancerous Conditions', 'Aneuploidy-formed-Precancerous Conditions', 'Aneuploidy-observed-Neoplasms', 'Aneuploidy-considered-Carcinogenesis', 'Neoplasms-considered-Carcinogenesis', 'Cystic Fibrosis-remain-Genetic Diseases, Inborn', 'Muscular Dystrophy, Duchenne-present-Muscle Weakness', 'Genetic Diseases, X-Linked-present-Muscle Weakness', 'Medulloblastoma-tend-Death', 'Cardiomyopathies-include-Hypertrophy', 'Cardiomyopathies-involved-Heart Diseases', 'Hypertrophy-involved-Heart Diseases', 'Cardiomyopathies-induced-Immunologic Deficiency Syndromes', 'Fragile X Syndrome-associated-Headache Disorders, Secondary', 'Headache Disorders, Secondary-associated-Fragile X Syndrome', 'Communicable Diseases-offset-Cardiovascular Diseases', 'Communicable Diseases-offset-Neoplasms', 'Stroke-think-Death', 'Stroke-think-Cardiovascular Diseases', 'Cystic Fibrosis-suffer-Infections', 'Neoplasm Metastasis-result-Melanoma', 'Glucose Metabolism Disorders-implicated-Huntington Disease', 'Metabolic Diseases-worsen-Death', 'Death-need-Metabolic Diseases', 'Respiratory Tract Diseases-complicate-Metabolic Diseases', 'Amyotrophic Lateral Sclerosis-cause-Muscular Atrophy', 'Amyotrophic Lateral Sclerosis-cause-Atrophy', 'Amyotrophic Lateral Sclerosis-result-Respiratory Insufficiency', 'Muscular Atrophy-result-Respiratory Insufficiency', 'Amyotrophic Lateral Sclerosis-typified-Canavan Disease', 'Intestinal Pseudo-Obstruction-typified-Canavan Disease', 'Aortic Aneurysm, Abdominal-consider-Diabetes Mellitus', 'Aneurysm, Ruptured-compare-Diabetes Mellitus', 'Death-predicted-Immune System Diseases', 'Cystic Fibrosis-compare-Diabetes Mellitus', 'Cystic Fibrosis-compare-Diabetes Mellitus, Type 2', 'Heart Failure-lead-Sleep Initiation and Maintenance Disorders', 'Headache Disorders, Secondary-include-Inflammation', 'Respiratory Tract Infections-include-Headache Disorders, Secondary', 'Multiple Endocrine Neoplasia Type 1-described-Neoplasms', 'Death-minimize-Drug-Related Side Effects and Adverse Reactions', 'Drug-Related Side Effects and Adverse Reactions-prevent-Neoplasms', 'Death-cause-Neuroendocrine Tumors', 'Cardiovascular Diseases-become-Myocardial Infarction', 'Death-reported-Primary Immunodeficiency Diseases', 'Genetic Diseases, Inborn-limit-Pancreatitis', 'Emphysema-followed-Cystic Fibrosis', 'Emphysema-followed-Pulmonary Fibrosis', 'Emphysema-followed-Pulmonary Arterial Hypertension', 'Emphysema-followed-Eisenmenger Complex', 'Intracranial Hemorrhages-occur-Hemophilia A', 'Eye Diseases-take-Scleritis', 'Eye Diseases-take-Keratitis', 'Eye Diseases-take-Retinitis', 'Arthritis, Rheumatoid-cause-Edema', 'Arthritis, Rheumatoid-cause-Color Vision Defects', 'Arthritis, Rheumatoid-cause-Death', 'Autoimmune Diseases-cause-Edema', 'Autoimmune Diseases-cause-Color Vision Defects', 'Autoimmune Diseases-cause-Death', 'Thalassemia-suffer-Osteoporotic Fractures', 'Thalassemia-encounter-Fractures, Bone', 'Epilepsies, Myoclonic-associated-Alzheimer Disease', 'Alzheimer Disease-associated-Epilepsies, Myoclonic', 'Pain-relieve-Dementia', 'Brain Death-follow-Leukemia', 'Brain Death-follow-Neoplasms', 'Neurodegenerative Diseases-pave-Huntington Disease', 'Hypertension-prevent-Lupus Erythematosus, Systemic', 'Neoplasm Metastasis-develop-Ulcer', 'Neoplasm Metastasis-develop-Hemorrhage', 'Pulmonary Valve Insufficiency-seen-Endocarditis', 'Neoplasms-done-Liver Diseases', 'Thalassemia-result-Anemia, Hemolytic', 'Hemoglobin C Disease-result-Anemia, Hemolytic', 'Osteoporosis-excluded-Hypogonadism', 'Spinal Cord Injuries-present-Prostatic Neoplasms', 'Prostatic Diseases-screen-Spinal Cord Injuries', 'Cardiovascular Diseases-emerge-Neoplasms', 'Hypogonadism-prevent-Osteoporosis', 'Osteoporosis-focus-Eunuchism', 'Cystic Fibrosis-undergo-Colorectal Neoplasms', 'Cystic Fibrosis-develop-Neoplasms', 'Arthritis, Rheumatoid-include-Vasculitis', 'Arthritis, Rheumatoid-include-Amyloidosis', 'Blindness-estimated-Hip Fractures', 'Vision, Low-estimated-Hip Fractures', 'Muscular Dystrophy, Duchenne-remain-Genetic Diseases, Inborn', 'Hip Fractures-require-Vision Disorders', 'Ocular Hypertension-prevent-Glaucoma', 'Ocular Hypertension-prevent-Hypertension', 'Angina Pectoris-defined-Sleep Initiation and Maintenance Disorders', 'Angina Pectoris-defined-Coronary Artery Disease', 'Coronary Artery Disease-characterized-Cardiomyopathies', 'Coronary Artery Disease-characterized-Ventricular Dysfunction, Left', 'Cardiomyopathies-characterized-Ventricular Dysfunction, Left', 'Multiple Organ Failure-follow-Shock, Traumatic', 'Multiple Organ Failure-prevent-Shock, Traumatic', 'Calcinosis-translate-Cardiovascular Diseases', 'Sarcoma, Kaposi-expressed-Death', 'Hemorrhage-related-Hypertension', 'Ascites-related-Hypertension', 'Pain-cause-Death', 'Neurologic Manifestations-cause-Death', 'Hip Fractures-differ-Fractures, Bone', 'Death-predict-Amyloidosis', 'Diabetes Mellitus-categorized-Cardiovascular Diseases', 'Diabetes Mellitus-categorized-Kidney Diseases', 'Diabetes Mellitus-categorized-Retinal Diseases', 'Diabetes Mellitus-categorized-Nervous System Diseases', 'Death-find-Myeloproliferative Disorders', 'Death-find-Neoplasms', 'Death-find-Parasitic Diseases', 'Neoplasms-follow-Cerebrovascular Disorders', 'Polycythemia-result-Heart Diseases', 'Hemolysis-reported-Biliary Tract Diseases', 'Ischemia-compared-Coronary Artery Disease', 'Retinal Artery Occlusion-confer-Death', 'Neoplasms-confer-Death', 'Vision Disorders-confer-Death', 'Retinal Artery Occlusion-found-Hypertension', 'Retinal Artery Occlusion-found-Atherosclerosis', 'Retinal Artery Occlusion-found-Diabetes Mellitus', 'Retinal Artery Occlusion-found-Heart Valve Diseases', 'Retinal Artery Occlusion-found-Stroke', 'Corneal Edema-include-Corneal Diseases', 'Cataract-include-Corneal Diseases', 'Hypercalcemia-attributed-Neoplasms', 'Hypercalcemia-attributed-Hyperparathyroidism', 'Hypercalcemia-attributed-Uremia', 'Neoplasms-attributed-Hyperparathyroidism', 'Neoplasms-coexist-Hyperparathyroidism', 'Neoplasms-attributed-Uremia', 'Aneurysm-recommend-Hypertension', 'Ischemia-suffer-Angina, Unstable', 'Wounds and Injuries-reach-Death', 'Drug-Related Side Effects and Adverse Reactions-experience-Agranulocytosis', 'Death, Sudden, Cardiac-base-Ventricular Fibrillation', 'Death, Sudden, Cardiac-contribute-Ventricular Fibrillation', 'Death-characterized-Communicable Diseases', 'Death-characterized-Tuberculosis', 'Cardiovascular Diseases-benefit-Turner Syndrome', 'Neoplasms-related-Mouth Diseases', 'Cystic Fibrosis-include-Hypoadrenocorticism, Familial', 'Cystic Fibrosis-associated-Hypoadrenocorticism, Familial', 'Hypoadrenocorticism, Familial-associated-Cystic Fibrosis', 'Cystic Fibrosis-include-Mouth Breathing', 'Cystic Fibrosis-associated-Mouth Breathing', 'Mouth Breathing-associated-Cystic Fibrosis', 'Cystic Fibrosis-include-Sinusitis', 'Cystic Fibrosis-associated-Sinusitis', 'Sinusitis-associated-Cystic Fibrosis', 'Hypoadrenocorticism, Familial-associated-Sinusitis', 'Sinusitis-associated-Hypoadrenocorticism, Familial', 'Mouth Breathing-associated-Sinusitis', 'Sinusitis-associated-Mouth Breathing', 'Amenorrhea-show-Ovarian Neoplasms', 'Acquired Immunodeficiency Syndrome-treated-Opportunistic Infections', 'Heart Failure-suffer-Angina Pectoris', 'Thrombocytosis-seen-Giant Cell Arteritis', 'Diabetes Mellitus-directed-Ischemia', 'Zoonoses-cause-Infections', 'Zoonoses-cause-Gastroenteritis', 'Hypoxia-confer-Death', 'Hearing Loss-provide-Neurodegenerative Diseases', 'Hypoxia-prevent-Ataxia', 'Hypoxia-prevent-Heredodegenerative Disorders, Nervous System', 'Hyperoxia-combine-Polycythemia', 'Drug-Related Side Effects and Adverse Reactions-result-Hyperoxia', 'Hyperoxia-result-Polycythemia', 'Polycythemia-blunt-Drug-Related Side Effects and Adverse Reactions', 'Heredodegenerative Disorders, Nervous System-reverse-Ataxia', 'Muscle Weakness-cause-Sarcopenia', 'Muscle Weakness-cause-Respiratory Tract Diseases', 'Rheumatic Diseases-suffer-Sarcopenia', 'Death-observed-Atrial Fibrillation', 'Dysbiosis-emerging-Neurodegenerative Diseases', 'Seizures-affect-Atrophy', 'Metabolic Syndrome-modify-Seizures', 'Death-appear-Obesity', 'Death-modify-Seizures', 'Obesity-modify-Seizures', 'Renal Insufficiency, Chronic-represent-Kidney Diseases', 'Stroke-compare-Cardiovascular Diseases', 'Nervous System Diseases-declined-Memory Disorders', 'Chronic Disease-burdened-Death', 'Chronic Disease-considered-Cardiovascular Diseases', 'Dementia-target-Cardiovascular Diseases', 'Hypothyroidism-include-Thyroid Diseases', 'Thyroid Diseases-play-Dementia', 'Hyperthyroidism-play-Dementia', 'Hypothyroidism-play-Dementia', 'Death-consider-Renal Insufficiency, Chronic', 'Neoplasms-multiplied-Death', 'Genetic Diseases, Inborn-range-Diabetes Mellitus', 'Genetic Diseases, Inborn-range-Neoplasms', 'Genetic Diseases, Inborn-range-Neurodegenerative Diseases', 'Lung Neoplasms-compare-Death', 'Leukemia, Lymphocytic, Chronic, B-Cell-result-Neoplasms', 'Carcinoma, Squamous Cell-tend-Death', 'Leukemia, Lymphocytic, Chronic, B-Cell-tend-Death', 'Critical Illness-included-Respiratory Insufficiency', 'Critical Illness-included-Shock', 'Critical Illness-included-Acute Kidney Injury', 'Critical Illness-included-Multiple Organ Failure', 'Neoplasms-affected-Infections', 'Renal Insufficiency-noted-Anemia', 'Respiratory Insufficiency-associated-Mucopolysaccharidoses', 'Mucopolysaccharidoses-associated-Respiratory Insufficiency', 'Hemophilia A-increased-Death', 'Death-decrease-Intracranial Hemorrhages', 'Hepatitis C-remain-Death', 'Prostatic Hyperplasia-considered-Prostatic Neoplasms', 'Infections-affect-Prostatic Hyperplasia', 'Burkitt Lymphoma-used-Lymphoma', 'Coronary Artery Disease-cause-Stroke', 'Coronary Artery Disease-cause-Neoplasms', 'Coronary Artery Disease-cause-Shock', 'Coronary Artery Disease-cause-Wounds and Injuries', 'Stroke-cause-Neoplasms', 'Stroke-cause-Shock', 'Stroke-cause-Wounds and Injuries', 'Dementia-estimate-Diabetes Mellitus', 'Death-calculate-Chronic Disease', 'Dementia-reduce-Memory Disorders', 'Fibrosis-compete-Death', 'Diabetes Mellitus-represent-Cardiovascular Diseases', 'Cardiovascular Diseases-experience-Diabetes Mellitus', 'Cardiovascular Diseases-experience-Hypertension', 'Hypertension-tend-Cardiovascular Diseases', 'Infertility, Male-caused-Abnormalities, Drug-Induced', 'Infertility, Male-caused-Endocrine System Diseases', 'Inflammation-diagnose-Epididymitis', 'Neoplasms-prevent-Infections', 'Death-surround-Aortic Aneurysm, Abdominal', 'Sclerosis-characterised-Fibrosis', 'Sclerosis-result-Death', 'Autoimmune Diseases-characterised-Fibrosis', 'Autoimmune Diseases-result-Death', 'Neoplasms-drive-Death', 'Thyroid Neoplasms-offset-Death', 'Amenorrhea-include-Turner Syndrome', 'Thalassemia-emerging-Osteoporosis', 'Hypogonadism-represent-Drug-Related Side Effects and Adverse Reactions', 'Hypogonadism-represent-Bone Diseases', 'Drug-Related Side Effects and Adverse Reactions-represent-Bone Diseases', 'Death-categorized-Colorectal Neoplasms', 'Diabetes Mellitus, Type 2-illustrated-Glucose Metabolism Disorders', 'Diabetes Mellitus, Type 2-result-Hyperglycemia', 'Cystinosis-develop-Kidney Failure, Chronic', 'Cystinosis-present-Signs and Symptoms, Digestive', 'Cystinosis-present-Vomiting', 'Cystinosis-present-Growth Disorders', 'Cancer Pain-occur-Bone Neoplasms', 'Cancer Pain-occur-Neoplasms', 'Pain-occur-Bone Neoplasms', 'Pain-occur-Neoplasms', 'Cystinosis-manage-Corneal Diseases', 'Cardiovascular Diseases-conduct-Hyperlipoproteinemia Type II', 'Death-calculated-Hyperlipoproteinemia Type II', 'Diabetes Mellitus, Type 2-registered-Diabetes Mellitus', 'Death-calculate-Diabetes Mellitus, Type 2', 'Death-calculate-Cerebrovascular Disorders', 'Diabetes Mellitus, Type 2-calculate-Cerebrovascular Disorders', 'Jaw Diseases-develop-Mouth Diseases', 'Seizures-accelerate-Death', 'Chronic Disease-accelerate-Death', 'Ossification, Heterotopic-lead-Ankylosis', 'Myositis Ossificans-confirmed-Fractures, Open', 'Ankylosis-involve-Ossification, Heterotopic', 'Ankylosis-result-Myositis Ossificans', 'Ossification, Heterotopic-result-Myositis Ossificans', 'Jaw Diseases-result-Myositis Ossificans', 'HIV Infections-favor-Cardiovascular Diseases', 'Fractures, Open-vary-Ossification, Heterotopic', 'Heart Diseases-associated-Aneurysm', 'Aneurysm-associated-Heart Diseases', 'Heart Diseases-associated-Ventricular Septal Rupture', 'Ventricular Septal Rupture-associated-Heart Diseases', 'HIV Infections-use-Cardiovascular Diseases', 'Heart Diseases-associated-Aortic Arch Syndromes', 'Aortic Arch Syndromes-associated-Heart Diseases', 'Anemia, Sickle Cell-associated-Anemia, Hemolytic', 'Anemia, Hemolytic-associated-Anemia, Sickle Cell', 'Genetic Diseases, Inborn-associated-Anemia, Hemolytic', 'Anemia, Hemolytic-associated-Genetic Diseases, Inborn', 'Neoplasms-play-Urinary Bladder Neoplasms', 'Neoplasms-compete-Death', 'Polycythemia Vera-associated-Thrombosis', 'Thrombosis-associated-Polycythemia Vera', 'Myeloproliferative Disorders-associated-Thrombosis', 'Thrombosis-associated-Myeloproliferative Disorders', 'Thrombosis-associated-Primary Myelofibrosis', 'Primary Myelofibrosis-associated-Thrombosis', 'Thrombosis-associated-Leukemia, Myeloid, Acute', 'Leukemia, Myeloid, Acute-associated-Thrombosis', 'Neoplasms-show-Mesothelioma', 'Cystic Fibrosis-identified-Multiple Organ Failure', 'Death-consider-Cross Infection', 'Death-affect-Cerebral Infarction', 'Venous Thrombosis-develop-Arthritis', 'Infections-develop-Arthritis', 'Femur Head Necrosis-develop-Arthritis', 'Cardiovascular Diseases-assess-Eclampsia', 'Carcinoma, Pancreatic Ductal-drive-Neoplasms', 'Carcinoma, Pancreatic Ductal-drive-Multiple Organ Failure', 'Carcinoma, Pancreatic Ductal-drive-Malnutrition', 'Neoplasms-drive-Multiple Organ Failure', 'Neoplasms-drive-Malnutrition', 'Death-influence-Parental Death', 'Death-imparted-Lung Neoplasms', 'Angiodysplasia-determine-Colorectal Neoplasms', 'Pancreatic Diseases-result-Adrenal Insufficiency', 'Pancreatic Diseases-result-Pancreatitis', 'Pancreatic Diseases-result-Liposarcoma', 'Coronary Artery Disease-remain-Cardiomyopathies', 'Coronary Artery Disease-remain-Myocardial Infarction', 'Hypertension-cause-Diabetes Mellitus', 'Death-cause-Diabetes Mellitus', 'Diabetes Mellitus-cause-Stroke', 'Diabetes Mellitus-cause-Blindness', 'Huntington Disease-include-Chorea', 'Huntington Disease-characterized-Chorea', 'Huntington Disease-include-Dementia', 'Huntington Disease-lead-Dementia', 'Chorea-lead-Dementia', 'Anemia, Sickle Cell-consider-Fetal Diseases', 'Aortic Aneurysm, Abdominal-compare-Breast Neoplasms', 'Huntington Disease-exhibit-Cardiovascular Diseases', 'Death, Sudden, Cardiac-reduce-Proteinuria', 'Death-lower-Heart Failure', 'Lymphoma-increase-Drug-Related Side Effects and Adverse Reactions', 'Death-see-Cardiovascular Diseases', 'Death-determined-Ovarian Diseases', 'Coronary Artery Disease-determined-Ovarian Diseases', 'Stroke-determined-Ovarian Diseases', 'Breast Neoplasms-determined-Ovarian Diseases', 'Carcinoma, Ovarian Epithelial-determined-Ovarian Diseases', 'Lung Neoplasms-determined-Ovarian Diseases', 'Colorectal Neoplasms-determined-Ovarian Diseases', 'Neoplasms-determined-Ovarian Diseases', 'von Hippel-Lindau Disease-characterized-Neoplasms', 'von Hippel-Lindau Disease-differentiate-Neoplasms', 'Glioma-receive-Neoplasms', 'Death-occur-Joint Diseases', 'Immunologic Deficiency Syndromes-include-Rheumatic Diseases', 'Arbovirus Infections-include-Rheumatic Diseases', 'Death-shift-Opportunistic Infections', 'Thrombosis-result-Myocardial Infarction', 'Huntington Disease-initiate-Arteriovenous Fistula', 'Death-remain-Huntington Disease', 'Anemia, Sickle Cell-known-Vision Disorders', 'Anemia, Sickle Cell-cause-Blindness', 'Diabetes Mellitus, Type 2-characterized-Tremor', 'Diabetes Mellitus, Type 2-characterized-Pancreatitis', 'Death-develop-Carcinoma, Hepatocellular', 'Heredodegenerative Disorders, Nervous System-diagnosed-Muscular Atrophy, Spinal', 'Critical Illness-defined-Ulcer', 'Critical Illness-defined-Arterial Occlusive Diseases', 'Critical Illness-attributed-Arterial Occlusive Diseases', 'Pain-attributed-Arterial Occlusive Diseases', 'Ulcer-attributed-Arterial Occlusive Diseases', 'Jaundice, Chronic Idiopathic-manifest-Jaundice', 'Infections-modify-Atherosclerosis', 'Jaundice, Chronic Idiopathic-manifest-Hyperbilirubinemia', 'Genetic Diseases, Inborn-manifest-Jaundice', 'Genetic Diseases, Inborn-manifest-Hyperbilirubinemia', 'Craniofacial Abnormalities-include-Hypertelorism', 'Craniofacial Abnormalities-include-Orbital Diseases', 'Cyanosis-accompanied-Nervous System Diseases', 'Genetic Diseases, Inborn-caused-Epilepsy, Benign Neonatal', 'Death-range-Neoplasms', 'Death-seek-Myocardial Infarction', 'Cardiovascular Diseases-seek-Myocardial Infarction', 'Aortic Coarctation-reduced-Ossification of Posterior Longitudinal Ligament', 'Muscle Weakness-explain-Dyspnea', 'Muscle Spasticity-followed-Paralysis', 'Demyelinating Diseases-result-Retinal Degeneration', 'Polycythemia-suffer-Polycythemia Vera', 'Neoplasms-balanced-Death', 'Death-increased-Arbovirus Infections', 'Aortic Aneurysm, Abdominal-underlie-Aneurysm', 'Nerve Degeneration-precede-Brain Injuries', 'Headache-suffer-Sleep Apnea, Obstructive', 'Neoplasms-experience-Neuralgia', 'Respiratory Tract Diseases-complicated-Cough', 'Myotonia Congenita-characterized-Muscle Weakness', 'Amyotrophic Lateral Sclerosis-cause-Nerve Degeneration', 'Nerve Degeneration-result-Paralysis', 'Nerve Degeneration-result-Death', 'Amyotrophic Lateral Sclerosis-understand-Adrenal Insufficiency', 'Fibrosis-influenced-Hepatitis C', 'Subarachnoid Hemorrhage-decrease-Death', 'Gastroesophageal Reflux-improve-Stomach Neoplasms', 'Adenoma-occur-Adenomatous Polyposis Coli', 'Ovarian Neoplasms-continue-Death', 'Death-compare-Glucose Intolerance', 'Neoplasms-recognized-Colonic Neoplasms', 'Adenoma-recognized-Colonic Neoplasms', 'Neoplasms-include-Adenoma', 'Coronary Artery Disease-undergo-Death', 'Cardiovascular Diseases-decreased-Death', 'Coinfection-modify-HIV Infections', 'Hepatitis C-enhance-HIV Infections', 'HIV Infections-modify-Hepatitis B', 'Hepatitis C-enhance-Liver Diseases', 'Liver Diseases-enhance-HIV Infections', 'Pleural Effusion-consist-Pneumothorax', 'Arrhythmias, Cardiac-associated-Death, Sudden, Cardiac', 'Death, Sudden, Cardiac-associated-Arrhythmias, Cardiac', 'Ischemia-initiate-Arrhythmias, Cardiac', 'Arrhythmias, Cardiac-associated-Ischemia', 'Ischemia-associated-Arrhythmias, Cardiac', 'Arrhythmias, Cardiac-documented-Tachycardia', 'Ischemia-documented-Tachycardia', 'Death-include-Stomach Ulcer', 'Mucopolysaccharidosis I-include-Hip Dislocation', 'Metabolic Diseases-include-Hip Dislocation', 'Neurologic Manifestations-lead-Exocrine Pancreatic Insufficiency', 'Peritoneal Neoplasms-based-Ascites', 'Peritoneal Neoplasms-based-Neoplasms', 'Carcinoid Tumor-occur-Neoplasms', 'Neoplasms-occur-Peritoneal Neoplasms', 'Death-related-Peritoneal Neoplasms', 'Acquired Immunodeficiency Syndrome-undergo-Uterine Hemorrhage', 'Neoplasms-classified-Uterine Cervical Neoplasms', 'Uterine Cervical Neoplasms-related-Immunologic Deficiency Syndromes', 'Death-affect-Heart Failure', 'Seizures-comprise-Wounds and Injuries', 'Stroke-comprise-Wounds and Injuries', 'Death-prevented-Pneumococcal Infections', 'Pituitary Neoplasms-involve-Hypothalamic Neoplasms', 'Atherosclerosis-involve-Heart Failure', 'Pituitary Neoplasms-reported-Myoclonus', 'Hypothalamic Neoplasms-reported-Myoclonus', 'Neoplasms-lose-Prostatic Neoplasms', 'Neoplasms-identified-Prostatic Neoplasms', 'Stroke-admitted-Thrombosis', 'Diabetes Mellitus-start-Stroke', 'Stroke-present-Hypertension', 'Stroke-present-Peripheral Vascular Diseases', 'Stroke-present-Diabetes Mellitus', 'Stroke-present-Myocardial Infarction', 'Neoplasms-detect-Seizures', 'Neoplasm Metastasis-comprise-Neoplasms', 'Neoplasm Metastasis-prevent-Death', 'Muscular Dystrophies-develop-Cardiomyopathies', 'Sepsis-implicated-Death', 'Hemorrhage-require-Paralysis', 'Cerebral Amyloid Angiopathy-accompanied-Hemorrhage', 'Myocardial Infarction-defined-Constriction, Pathologic', 'Constriction, Pathologic-defined-Myocardial Infarction', 'Hemolysis-include-Hypertension', 'Thyroid Neoplasms-represent-Neoplasms', 'Neoplasms-involve-Thyroid Neoplasms', 'Breast Neoplasms-diagnosed-Neoplasms, Multiple Primary', 'Hypertension-raise-Death, Sudden, Cardiac', 'Lymphatic Diseases-elevate-Death, Sudden, Cardiac', 'Abnormalities, Drug-Induced-affect-Death', 'Cholestasis-show-Crigler-Najjar Syndrome', 'Cholangitis-show-Crigler-Najjar Syndrome', 'Sleep Apnea Syndromes-associated-Hypertrophy', 'Hypertrophy-associated-Sleep Apnea Syndromes', 'Genetic Diseases, Inborn-cause-Cardiovascular Diseases', 'Coronary Artery Disease-cure-Vision Disorders', 'Acquired Immunodeficiency Syndrome-use-Death', 'Death-related-Hypothyroidism', 'Hypothyroidism-linked-Heart Diseases', 'Hypothyroidism-linked-Atherosclerosis', 'Hypothyroidism-increase-Death', 'Hypothyroidism-linked-Hypertension', 'Hypothyroidism-linked-Blood Coagulation Disorders', 'Aortic Aneurysm, Abdominal-tend-Rupture', 'Aortic Aneurysm, Abdominal-tend-Death', 'Aortic Aneurysm, Abdominal-prevent-Death', 'Diabetic Nephropathies-estimate-Kidney Diseases', 'Cardiac Complexes, Premature-comprise-Aortic Valve Insufficiency', 'Thrombosis-demonstrate-Aneurysm', 'Thrombosis-demonstrate-Necrosis', 'Marfan Syndrome-treat-Aortic Aneurysm, Abdominal', 'Aneurysm-demonstrate-Necrosis', 'Surgical Wound Infection-increase-Substance-Related Disorders', 'Death-induced-Ischemia', 'Brain Injuries-induced-Ischemia', 'Alcoholism-blamed-Death', 'Neoplasms-encode-Heart Arrest', 'Death-decline-Communicable Diseases', 'Tuberculosis-persist-Infections', 'Death-define-Communicable Diseases', 'Neoplasms-prevent-Acquired Immunodeficiency Syndrome', 'MIR455-encode-COL27A1', 'ATF3-increased-Breast Neoplasms', 'CCAT1-investigate-ASH1L', 'ASH1L-contribute-Thyroid Carcinoma, Anaplastic', 'Thyroid Carcinoma, Anaplastic-suggest-CCAT1', 'MEG3-associated-VEGFA', 'VEGFA-associated-MEG3', 'VEGFA-involved-Osteoarthritis', 'MEG3-involved-Osteoarthritis', 'GGH-degrade-Starch', 'Glucose-administer-INS', 'Etoposide-increase-SIRT1', 'INS-establish-Glucose', 'Glucose-receive-INS', 'Glucose-enable-INS', 'INS-viewed-Cardiac Output, High', 'Diabetes, Gestational-treat-INS', 'Diabetes, Gestational-treat-Glucose', 'Infections-associated-Glucose', 'Glucose-associated-Infections', 'INS-necessitate-Glucose', 'INS-increase-Cystic Fibrosis', 'Glucose-increase-Cystic Fibrosis', 'Glucose-lowering-INS', 'IL2-target-Neoplasms', 'TTR-activate-Anthocyanins', 'OGN-associated-Glucose', 'Glucose-associated-OGN', 'Glucose-involve-SLC2A1', 'GSR-incubate-Sugars', 'Heparin-used-GDF5', 'Heparin-sustain-GDF5', 'Bleomycin-identify-AKT1', 'ISG15-treated-Lipopolysaccharides', 'Glucose-use-MTCH2', 'Heart Failure-use-Glucose', 'Lipopolysaccharides-decrease-IL6', 'SIRT1-exert-Glucose', 'Aminoglycosides-result-SMN1', 'WEE1-required-Heart Arrest', 'Glucose-deliver-INS', 'Daunorubicin-reveal-Drug-Related Side Effects and Adverse Reactions', 'MAGEA10-enhance-Polysaccharides', 'Neoplasms-enhance-Polysaccharides', 'INS-reached-Glucose', 'CCL5-correlate-Heparin', 'TF-conjugated-Doxorubicin', 'IDUA-decrease-Glycosaminoglycans', 'CDK9-induce-Drug-Related Side Effects and Adverse Reactions', 'N-Acetylneuraminic Acid-produce-EPO', 'PEMT-induced-Fatty Acids, Omega-3', 'CCL2-decrease-Dinoprostone', 'NPC1-regulate-Cholesterol', 'Cholecalciferol-induce-ALPP', 'Cholesterol-related-Glioma', 'ACAT1-control-Cholesterol', 'Fatty Acids-use-INS', 'Fatty Acids-use-Glucose Metabolism Disorders', 'ACSS2-convert-Acetates', 'SIRT6-reduced-Palmitates', 'NFE2L2-act-Fatty Acids, Omega-3', 'INS-associated-Cystic Fibrosis', 'Cystic Fibrosis-associated-INS', 'Cholesterol-associated-Cystic Fibrosis', 'Cystic Fibrosis-associated-Cholesterol', 'MBTPS2-impair-Cholesterol', 'Cholesterol-show-GH1', 'Phosphatidylinositols-inhibit-TMEM37', 'Valproic Acid-established-NPC1', 'CFTR-enhance-Dinoprostone', 'NPC1-mediate-Cholesterol', 'AGPAT2-lead-Triglycerides', 'Genetic Diseases, Inborn-lead-Triglycerides', 'MFN2-share-Cholesterol Esters', 'Triglycerides-break-INS', 'MFN2-form-Cholesterol', 'ESR2-associated-Cholesterol', 'Cholesterol-associated-ESR2', 'FASN-involved-Fatty Acids', 'rs3020449-associated-Cholesterol', 'Cholesterol-associated-rs3020449', 'Mevalonate Kinase Deficiency-represent-Cholesterol', 'Calcifediol-demonstrate-TNFRSF11B', 'Calcifediol-demonstrate-Vascular Calcification', 'LDLRAP1-compare-Hyperlipoproteinemia Type II', 'Ionomycin-bind-ANXA5', 'ALB-remain-Cholesterol', 'SIRT3-involved-Fatty Acids', 'INS-confer-Insulin Glargine', 'INS-compare-Diabetes Mellitus, Type 2', 'INS-result-Diabetes Mellitus, Type 2', 'Insulin Glargine-result-Diabetes Mellitus, Type 2', 'Insulin Glargine-receive-Diabetes Mellitus', 'Octreotide-inhibit-GH1', 'Oxytocin-influence-OXTR', 'CAT-taken-Jaundice, Obstructive', 'Glutathione-taken-Jaundice, Obstructive', 'Hypoglycemia-use-INS', 'Hypoglycemia-use-Insulin Glargine', 'Urinary Bladder Neoplasms-give-NAT2', 'Urinary Bladder Neoplasms-give-Glutathione', 'INS-result-Insulin Glargine', 'Octreotide-achieve-GGH', 'Carnosine-translocate-NFE2L2', 'Diabetes Mellitus-recommended-INS', 'Diabetes Mellitus-recommended-Insulin Glargine', 'Glutathione-suppress-NFE2L2', 'INS-demonstrated-Insulin Glargine', 'MBP-suppress-Drug Hypersensitivity', 'Glatiramer Acetate-suppress-Drug Hypersensitivity', 'Glatiramer Acetate-related-MBP', 'Glatiramer Acetate-denoted-MBP', 'Multiple Sclerosis-denoted-Glatiramer Acetate', 'RAD51-distinguish-Trimethoprim, Sulfamethoxazole Drug Combination', 'PRKAA1-increase-Infliximab', 'Infliximab-link-PRKAA1', 'Trastuzumab-targeted-ERBB2', 'ERBB2-emerge-Cardiotoxicity', 'Trastuzumab-overexpress-ERBB2', 'Trastuzumab-emerge-Cardiotoxicity', 'Breast Neoplasms-overexpress-ERBB2', 'Trastuzumab-show-Breast Neoplasms', 'Cetuximab-bind-EGFR', 'ANXA5-regulate-Infliximab', 'Neoplasms-carry-KRAS', 'Neoplasms-carry-Cetuximab', 'PIEZO1-driven-Infliximab', 'Infliximab-activate-PRKAA2', 'TP53-serve-Carcinoma, Hepatocellular', 'MITF-result-Neoplasms', 'rs113488022-result-Neoplasms', 'FBN1-associated-Marfan Syndrome', 'Marfan Syndrome-associated-FBN1', 'rs747713929-associated-Marfan Syndrome', 'Marfan Syndrome-associated-rs747713929', 'rs104894584-facilitate-Arrhythmias, Cardiac', 'KCNQ1-promote-Atrial Fibrillation', 'rs120074192-promote-Atrial Fibrillation', 'KCNQ1-associated-Atrial Fibrillation', 'Atrial Fibrillation-associated-KCNQ1', 'rs120074192-associated-Atrial Fibrillation', 'Atrial Fibrillation-associated-rs120074192', 'rs63751438-detected-MAPT', 'MAPT-developed-rs63751438', 'MAPT-accumulate-Atrophy', 'Nerve Degeneration-rescue-rs104893877', 'rs63751438-attenuate-MAPT', 'MAPT-link-Tauopathies', 'RSF1-implicated-Breast Neoplasms', 'Breast Neoplasms-implicated-rs11604207', 'Primary Ovarian Insufficiency-carry-CAV1', 'Primary Ovarian Insufficiency-carry-rs866236602', 'rs16991615-reach-AMH', 'LRRK2-provide-Neurodegenerative Diseases', 'rs141688754-involve-PCNA', 'rs1800795-link-IL6', 'rs63751438-conclude-MAPT', 'rs63751438-conclude-Neurodegenerative Diseases', 'rs1799964-correlate-Heart Failure', 'MAPT-survive-rs63750424', 'Neoplasms-carry-rs121913530', 'TERT-associated-rs2853672', 'rs2853672-associated-TERT', 'TERT-associated-Death', 'Death-associated-TERT', 'rs2853691-associated-Death', 'Death-associated-rs2853691', 'rs63750424-cause-MAPT', 'Leigh Disease-tested-SLC19A3', 'Leigh Disease-tested-rs713993048', 'SOD1-reduce-Liver Neoplasms', 'rs121912438-reduce-Liver Neoplasms', 'Atrial Fibrillation-linked-KCNJ2', 'Atrial Fibrillation-linked-rs147750704', 'KCNJ2-increase-Arrhythmias, Cardiac', 'rs147750704-increase-Arrhythmias, Cardiac', 'Myositis Ossificans-caused-rs121912678', 'Achondroplasia-caused-rs28931614', 'PRKCD-include-rs606231296', 'Arbovirus Infections-include-rs606231296', 'CHCHD10-identified-Muscular Atrophy, Spinal', 'Porphyria, Erythropoietic-caused-UROS', 'Porphyria, Erythropoietic-associated-rs121908012', 'rs121908012-associated-Porphyria, Erythropoietic', 'Porphyria, Erythropoietic-caused-rs121908012', 'SERPINA12-compare-Kidney Failure, Chronic', 'rs2236242-compare-Kidney Failure, Chronic', 'SETBP1-find-rs267607040', 'THADA-associated-Metabolic Syndrome', 'Metabolic Syndrome-associated-THADA', 'INSR-associated-Metabolic Syndrome', 'Metabolic Syndrome-associated-INSR', 'rs12478601-associated-Metabolic Syndrome', 'Metabolic Syndrome-associated-rs12478601', 'rs2059807-associated-Metabolic Syndrome', 'Metabolic Syndrome-associated-rs2059807', 'rs11077-display-XPO5', 'XPO5-associated-Esophageal Squamous Cell Carcinoma', 'Esophageal Squamous Cell Carcinoma-associated-XPO5', 'rs11077-display-Esophageal Squamous Cell Carcinoma', 'AMH-decline-Neoplasms', 'AGER-considered-Diabetic Angiopathies', 'Infections-performed-INS', 'INS-estimated-Diabetes Mellitus', 'Diabetes Mellitus-afford-INS', 'Polycythemia Vera-diagnosed-EPO', 'Prostatic Neoplasms-detected-KLK3', 'Neoplasms-diagnosed-KLK3', 'Neoplasms-assayed-KLK3', 'Diabetes Mellitus-diagnose-ALB', 'INS-control-Hyperglycemia', 'Glioma-target-MGMT', 'INS-fail-Hyperglycemia', 'Glioma-regulated-MGMT', 'Infertility, Female-base-AMH', 'Infertility, Female-compare-AMH', 'Diabetes Mellitus-remain-INS', 'ATP6V0C-result-Seizures', 'SIRT6-implicated-Neoplasms', 'CD4-begin-Pneumonia, Pneumocystis', 'SPON2-identify-Prostatic Neoplasms', 'GFAP-highlight-Gliosis', 'CFH-detected-Macular Degeneration', 'Thrombocytopenia-considered-THPO', 'PTHLH-screened-Neoplasms', 'MCL1-isolate-Leukemia, Myeloid', 'Genetic Diseases, Inborn-caused-CYP27A1', 'Prostatic Neoplasms-decrease-KLK3', 'Neoplasms-increase-KLK3', 'CRP-form-Inflammation', 'Amyotrophic Lateral Sclerosis-enriched-SYT13', 'AMACR-identified-Prostatic Neoplasms', 'Prostatic Neoplasms-include-AR', 'AR-act-Neoplasms', 'ERBB2-review-Neoplasms', 'TNFSF13B-studied-Lupus Erythematosus, Systemic', 'HGF-derived-Breast Neoplasms', 'TNFSF13B-approved-Lupus Erythematosus, Systemic', 'Cystic Fibrosis-test-CFTR', 'Lung Neoplasms-develop-ALK', 'CRP-validated-Neoplasms', 'ACHE-alleviate-Alzheimer Disease', 'Parkinson Disease-utilize-SYNM', 'Heart Failure-correlated-CRP', 'Kidney Diseases-differentiate-CD79A', 'Fibrosis-develop-EGF', 'AMH-understood-Neoplasms', 'Ovarian Neoplasms-associated-ELAVL1', 'ELAVL1-associated-Ovarian Neoplasms', 'GRN-investigated-Neurodegenerative Diseases', 'Prostatic Neoplasms-occur-CD4', 'AKT1-rescue-Death', 'MEN1-characterized-Pituitary Diseases', 'SIRT3-cause-Heart Arrest', 'Drug Hypersensitivity-measure-SCGB1A1', 'INS-stimulate-Neoplasms', 'NHEJ1-impair-Ovarian Diseases', 'IL21-transplanted-Ovarian Neoplasms', 'GPNMB-expressed-Neoplasms', 'NR4A3-increased-Inflammation', 'Neoplasms-show-PTPA', 'DMD-cease-Necrosis', 'CDKN2A-described-Neoplasms', 'Aortic Aneurysm-associated-ELN', 'ELN-associated-Aortic Aneurysm', 'Muscular Dystrophy, Duchenne-follow-DMD', 'Basal Cell Nevus Syndrome-caused-PTCH1', 'OGN-associated-Seizures', 'Seizures-associated-OGN', 'SIRT1-influence-Alzheimer Disease', 'SLC5A2-appear-Glycosuria', 'SLC5A2-play-Diabetes Mellitus', 'CFTR-cause-Cystic Fibrosis', 'Cystic Fibrosis-cause-CFTR', 'EGFR-investigate-Urinary Bladder Neoplasms', 'EGFR-implicated-Neoplasms', 'F8-suffer-Hemophilia A', 'ATM-radiosensitize-Glioblastoma', 'SOX2-identify-Glioblastoma', 'SOX2-misregulated-Neoplasms', 'Ataxia Telangiectasia-activate-TP53', 'Neoplasms-help-SOX2', 'BRCA2-stratified-Adenocarcinoma', 'TERT-reported-Neoplasms', 'CYP3A4-lead-Long QT Syndrome', 'Pulmonary Disease, Chronic Obstructive-exhibit-TACC2', 'TACC2-augment-Drug-Related Side Effects and Adverse Reactions', 'VEGFA-studied-Neoplasms', 'FOXO3-alter-Neoplasms', 'FOXO3-exhibit-Neoplasms', 'NFATC1-identify-Leukemia, Lymphoid', 'NFATC1-linked-Leukemia, Lymphoid', 'INS-include-Pancreatitis', 'INS-replicate-Pancreatitis', 'MAPT-define-Alzheimer Disease', 'Diabetes Mellitus-prevent-INS', 'SIRT1-connect-Neurodegenerative Diseases', 'SMN1-overexpress-Muscular Atrophy, Spinal', 'RAC1-suppress-Glioblastoma', 'Seizures-associated-APOA1', 'APOA1-associated-Seizures', 'Death-associated-KLK3', 'KLK3-associated-Death', 'MAPT-rescue-Neurodegenerative Diseases', 'Hemolysis-depleted-HPX', 'CST3-design-Kidney Diseases', 'TERT-rescue-Dyskeratosis Congenita', 'TERT-provide-Dyskeratosis Congenita', 'PARP1-delay-Neoplasms', 'Fibrosis-result-VTN', 'Dyskeratosis Congenita-provide-TERT', 'TERT-result-Dyskeratosis Congenita', 'Lung Neoplasms-associated-CFTR', 'CFTR-associated-Lung Neoplasms', 'CFTR-develop-Neoplasms', 'DKK3-associated-Acute Kidney Injury', 'Acute Kidney Injury-associated-DKK3', 'CFTR-monitor-Edema', 'Cystic Fibrosis-donated-CFTR', 'Hemophilia A-based-F8', 'ACE-provide-Renal Insufficiency', 'DKK3-highlight-Kidney Diseases', 'Myotonic Dystrophy-caused-DMPK', 'TSPO-studied-Astrocytoma', 'Neoplasms-show-TSPO', 'KLK3-miss-Neoplasms', 'NF1-predispose-Neoplasms', 'NF2-misdiagnosed-Neuroma, Acoustic', 'KIR2DL1-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-KIR2DL1', 'Prostatic Neoplasms-followed-KLK3', 'LPL-applied-Leukemia, Lymphocytic, Chronic, B-Cell', 'LPL-correlate-Leukemia, Lymphocytic, Chronic, B-Cell', 'Muscular Diseases-associated-ZMPSTE24', 'ZMPSTE24-associated-Muscular Diseases', 'Hypoglycemia-compare-INS', 'TP53-observed-Adenoma', 'ALK-elevated-Alzheimer Disease', 'MYT1L-associate-Memory Disorders', 'Memory Disorders-associate-MYT1L', 'Death-anchor-TERF1', 'MTOR-used-Neoplasms', 'Alzheimer Disease-present-MAPT', 'FASN-played-Neoplasms', 'ARL6IP1-display-Movement Disorders', 'IFNA1-activated-Amyotrophic Lateral Sclerosis', 'IFNA1-represent-Amyotrophic Lateral Sclerosis', 'SPHK1-associated-Pulmonary Fibrosis', 'Pulmonary Fibrosis-associated-SPHK1', 'MSTN-spark-Muscular Atrophy', 'INS-reverse-Weight Loss', 'CD79A-provide-Mevalonate Kinase Deficiency', 'Liver Neoplasms-carry-SOD1', 'SOD1-include-Amyotrophic Lateral Sclerosis', 'IGLL5-correlated-Arthritis, Rheumatoid', 'SSX2-result-Cardiac Output, Low', 'SSX2-expressed-Neoplasms', 'INS-recognize-Hypoglycemia', 'KLK3-discussed-Prostatic Neoplasms', 'KLK3-consider-Prostatic Neoplasms', 'GEMIN5-result-Ataxia', 'LDHB-identify-Breast Neoplasms', 'ACE-show-Cardiomyopathy, Dilated', 'ID1-detected-Neoplasms', 'AR-affect-Neoplasms', 'INS-compensated-Adrenal Insufficiency', 'Carcinoma, Non-Small-Cell Lung-receive-EGFR', 'Neoplasms-reduce-GH1', 'DDC-remain-Parkinson Disease', 'Chemical and Drug Induced Liver Injury-normalize-GPT', 'Liver Neoplasms-misfolded-SOD1', 'Heart Defects, Congenital-reflect-NRG1', 'AKT1-activated-Retinoblastoma', 'Polycystic Kidney Diseases-linked-PKD1', 'PKD1-represent-Polycystic Kidney Diseases', 'Glioma-exhibit-TNFRSF10B', 'CHEK2-form-Heart Arrest', 'INS-manifest-Hypoglycemia', 'INS-reduce-Glucose Intolerance', 'MAPT-exhibit-Tauopathies', 'ALK-bear-Carcinoma, Non-Small-Cell Lung', 'SMN1-emerge-Muscular Atrophy, Spinal', 'IL2-regarded-Neoplasms', 'MPO-attenuate-Sepsis', 'DDC-continue-Parkinson Disease', 'ATF3-regulate-Breast Neoplasms', 'CDK9-lead-Neoplasms', 'ATF3-mitigate-Breast Neoplasms', 'APOE-carry-Death', 'Prostatic Neoplasms-recommended-NPEPPS', 'Glioma-found-NF1', 'KLK3-offered-Prostatic Neoplasms', 'KLK3-predicted-Neoplasms', 'PFN1-result-Gait Disorders, Neurologic', 'KLK3-provide-Neoplasms', 'Neurologic Manifestations-express-SOD1', 'LRRK2-exacerbated-Retinal Degeneration', 'KLK3-increase-Spinal Cord Injuries', 'SCUBE2-increase-Coronary Artery Disease', 'SCUBE2-show-Diabetes Mellitus, Type 2', 'Achlorhydria-diminish-GAST', 'Leigh Disease-carry-NDUFS4', 'Colorectal Neoplasms, Hereditary Nonpolyposis-followed-BRAF', 'Mitochondrial Diseases-described-PRKAA1', 'ACE-challenge-Heart Failure', 'Neoplasms-compare-TNF', 'IGF2-maintained-Amyotrophic Lateral Sclerosis', 'Neoplasms-characterised-MYCN', 'TPCN2-assessed-Mucolipidoses', 'Intellectual Disability-associated-APOE', 'APOE-associated-Intellectual Disability', 'VCP-involved-Alzheimer Disease', 'Hyperglycemia-recommended-INS', 'SOD1-show-Liver Neoplasms', 'MAP3K7-play-Neoplasms', 'Neoplasms-influence-NF1', 'Ovarian Neoplasms-examine-INS', 'MEN1-identified-Multiple Endocrine Neoplasia Type 1', 'SULT1A1-linked-Infections', 'CFTR-result-Cystic Fibrosis', 'Prostatic Neoplasms-perceived-NPEPPS', 'MCHR1-considered-Fibrosis', 'Neoplasms-appear-KLK3', 'F8-reduce-Hemophilia A', 'Death-predict-ALB', 'Obesity-exert-LEP', 'CYP3A4-metabolized-Leukemia, Myeloid, Acute', 'Ischemia-reduce-INS', 'INS-improve-Peripheral Arterial Disease', 'Obesity, Abdominal-reviewed-INS', 'Diabetes Mellitus-involve-FOXO1', 'INS-include-Weight Gain', 'Neoplasms-considered-CDKN2A', 'Diabetes Mellitus-display-HBA1', 'Breast Neoplasms-triggered-BAX', 'CFTR-learned-Cystic Fibrosis', 'Glioma-involved-ACAT1', 'Glioblastoma-overexpressed-ACAT1', 'RAD52-facilitate-Neoplasms', 'Death-confer-CD4', 'CD4-reduce-Infections', 'SIRT1-evaluated-Diabetes Mellitus, Type 2', 'WWOX-lead-Death', 'Colonic Neoplasms-co-localize-BAK1', 'PEX7-contribute-Chondrodysplasia Punctata, Rhizomelic', 'KCNH1-include-Neoplasms', 'VEGFA-found-Osteoarthritis', 'CXCL9-involved-Ventricular Remodeling', 'KCNH1-involved-Neoplasms', 'KCNH1-regulate-Retinoblastoma', 'KCNH1-investigate-Retinoblastoma', 'Retinoblastoma-display-KCNH1', 'Unconsciousness-activate-PRKAA2', 'Genetic Diseases, Inborn-associated-CFTR', 'CFTR-associated-Genetic Diseases, Inborn', 'ACVR1-identified-Myositis Ossificans', 'HTT-alter-Huntington Disease', 'Delirium-activate-PRKAA2', 'Cystic Fibrosis-account-CFTR', 'Cystic Fibrosis-defined-CFTR', 'Cystic Fibrosis-alter-CFTR', 'EPO-need-Myelodysplastic Syndromes', 'COMT-metabolized-Hypertension', 'GH1-result-Pulmonary Heart Disease', 'Cystic Fibrosis-focus-CFTR', 'Muscular Atrophy, Spinal-carry-SMN2', 'Cystic Fibrosis-improve-CFTR', 'ATXN7-study-Communicable Diseases', 'ACE-administer-Kidney Diseases', 'Cystic Fibrosis-find-CFTR', 'Cystic Fibrosis-wait-CFTR', 'Drug-Related Side Effects and Adverse Reactions-increased-FMR1', 'TTR-associated-Cardiomyopathies', 'Cardiomyopathies-associated-TTR', 'Tauopathies-exhibit-MAPT', 'TP53-expose-Neoplasms', 'Osteogenesis Imperfecta-caused-COL1A2', 'MAPT-cause-Tauopathies', 'MAPT-associated-Tauopathies', 'Tauopathies-associated-MAPT', 'METTL5-elevated-Breast Neoplasms', 'Pheochromocytoma-occur-VHL', 'Nerve Degeneration-express-HTT', 'CAV1-sequenced-Primary Ovarian Insufficiency', 'CRTC1-involved-Obesity', 'MAPKAPK3-delete-Neoplasms', 'WWOX-modulated-Glioblastoma', 'MAPKAPK3-enhance-Neoplasms', 'WWOX-induce-Glioblastoma', 'RPL3-induce-Death', 'INS-limited-Drug-Related Side Effects and Adverse Reactions', 'Neoplasms-tested-KIT', 'NPEPPS-eradicate-Prostatic Neoplasms', 'SIRT6-implicate-Neoplasms', 'Neoplasms-bind-TPP1', 'Fabry Disease-include-GLA', 'BTK-continued-Drug-Related Side Effects and Adverse Reactions', 'Discitis-defined-CRP', 'TERT-arose-Neoplasms', 'Cystic Fibrosis-target-CFTR', 'AR-undergo-Nerve Degeneration', 'AR-accumulate-Nerve Degeneration', 'Glioblastoma-maintained-EGFL7', 'EGFL7-associated-Neoplasms', 'Neoplasms-associated-EGFL7', 'APLN-measured-Anemia, Sickle Cell', 'APLN-correlated-Pain', 'Cystic Fibrosis-termed-CFTR', 'TERF2-find-Breast Neoplasms', 'ABCC4-confer-Drug-Related Side Effects and Adverse Reactions', 'ABCC4-used-Drug-Related Side Effects and Adverse Reactions', 'ABCC4-assess-Drug-Related Side Effects and Adverse Reactions', 'Prostatic Neoplasms-display-AKT1', 'SIRT1-decelerate-Vascular Calcification', 'ACOX1-exhibit-Glioma', 'TNFSF11-associate-Periodontitis', 'Periodontitis-associate-TNFSF11', 'TNFSF11-seen-Periodontitis', 'SIRT1-increased-Hypoxia', 'CD4-develop-Infections', 'TF-identify-Hemochromatosis', 'Prostatic Neoplasms-intensify-KLK3', 'PRL-contribute-Lupus Erythematosus, Systemic', 'LRPPRC-characterize-Neoplasms', 'LRPPRC-act-Neoplasms', 'NEFL-emerge-Heredodegenerative Disorders, Nervous System', 'ISG15-provide-Carcinoma, Hepatocellular', 'ISG15-over-expressing-Carcinoma, Hepatocellular', 'ISG15-expressed-Carcinoma, Hepatocellular', 'TGFB1-determined-Stomach Neoplasms', 'TANGO2-confront-Rhabdomyolysis', 'TNFSF10-kill-Glioma', 'CBL-reported-Leukemia, Myelomonocytic, Juvenile', 'NR1I3-efficacy-Melanoma', 'HHEX-governed-Hematologic Neoplasms', 'AK1-increased-Alzheimer Disease', 'PPT1-described-Neuronal Ceroid-Lipofuscinoses', 'Muscular Dystrophies-align-MAPT', 'Muscular Dystrophies-harbour-MAPT', 'GDF2-differentiate-Osteosarcoma', 'TREM1-associated-Shock, Septic', 'Shock, Septic-associated-TREM1', 'NOTCH1-identify-Prostatic Neoplasms', 'TRPA1-expressed-Pain', 'CDC42-involved-Inflammation', 'CDC42-identify-Inflammation', 'Seizures-derived-TERT', 'Seizures-extend-TERT', 'Neoplasms-change-KLK3', 'Death-vary-CD4', 'PLAU-implicate-Neoplasms', 'Neoplasms-contribute-AMH', 'AMH-compared-Breast Neoplasms', 'MAPT-exhibit-Neurodegenerative Diseases', 'PRL-increase-Adenoma', 'Adenoma-detected-PRL', 'ADCYAP1-prevent-Kidney Diseases', 'TET2-described-Mastocytosis, Systemic', 'Prolactinoma-decrease-PRL', 'Wounds and Injuries-associated-IL6', 'IL6-associated-Wounds and Injuries', 'IL6-related-Wounds and Injuries', 'Genetic Predisposition to Disease-caused-NF2', 'NDUFS4-develop-Nervous System Diseases', 'Huntington Disease-target-HTT', 'JAK2-define-Polycythemia Vera', 'Prostatic Neoplasms-increase-NPEPPS', 'FANCB-inhibit-Blood Platelet Disorders', 'Diabetes Mellitus-based-INS', 'CD4-associated-Pain', 'Pain-associated-CD4', 'Neoplasms-reflect-KLK3', 'STING1-treat-Kidney Diseases', 'RFWD3-propose-Fanconi Anemia', 'Cardiovascular Diseases-generate-PCSK9', 'TNFRSF11B-correlate-Colorectal Neoplasms', 'Dysplastic Nevus Syndrome-distinguish-SAMD9', 'FABP3-identify-Neoplasms', 'UBA5-induce-Gait Disorders, Neurologic', 'WWP1-play-Neoplasms', 'SVIP-cause-Neuromuscular Diseases', 'MAPT-reduce-Paralysis', 'Nijmegen Breakage Syndrome-carry-NBN', 'Primary Ovarian Insufficiency-caused-FMR1', 'FMR1-caused-Primary Ovarian Insufficiency', 'Ovarian Diseases-result-FMR1', 'DKK1-used-Arthritis, Rheumatoid', 'BYSL-Silencing-Glioma', 'BYSL-inhibit-Glioma', 'GNRH1-drive-Puberty, Delayed', 'Chordoma-checked-LIF', 'LIF-associated-Neoplasms', 'Neoplasms-associated-LIF', 'LIF-increase-Chordoma', 'INS-recommended-Hypoglycemia', 'Polycystic Kidney Diseases-cross-mate-PKD2', 'TNFSF10-influence-Death', 'BMP2-promote-Osteogenesis Imperfecta', 'Metaplasia-exhibit-KRT10', 'INS-constrained-Weight Gain', 'Stomach Neoplasms-transfected-CBX7', 'PTH-associated-Periodontitis', 'Periodontitis-associated-PTH', 'PTH-improve-Fractures, Bone', 'Amyotrophic Lateral Sclerosis-linked-SOD1', 'Leukoencephalopathies-sequester-ACVR2B', 'SOD1-modify-Amyotrophic Lateral Sclerosis', 'Hereditary Central Nervous System Demyelinating Diseases-reveal-ACVR2A', 'CUX1-identify-Atherosclerosis', 'Infections-infect-TP53', 'VASP-increased-Carcinoma, Hepatocellular', 'TP53-correlated-Neoplasms', 'Death-increase-ALB', 'ENDOU-link-Neoplasms', 'NPEPPS-miss-Neoplasms', 'PTEN-promote-Neoplasms', 'PTEN-reduce-Neoplasms', 'PTEN-detected-Breast Neoplasms', 'Acromegaly-cured-GH1', 'Mitochondrial Diseases-coupled-AKT1', 'SLC5A2-prevent-Diabetes Mellitus, Type 2', 'INS-improved-Fibrosis', 'Neoplasms-include-TP53', 'EGFR-repurposed-Inflammation', 'HTT-display-Neurodegenerative Diseases', 'EGFR-identify-Inflammation', 'EGFR-reduce-Inflammation', 'Acute Kidney Injury-expressed-CDKN2B', 'PPP1R13B-related-Neoplasms', 'HFE-done-Porphyria Cutanea Tarda', 'Hypoxia-attenuated-EPO', 'CFTR-improve-Cystic Fibrosis', 'FASLG-upregulated-Myelodysplastic Syndromes', 'INS-regulate-Death', 'AMH-aid-Breast Neoplasms', 'AMH-shown-Ovarian Diseases', 'RAC1-regulate-Glioma', 'RAC1-suppress-Glioma', 'Fragile X Syndrome-include-FMR1', 'Inflammation-suppress-TTR', 'HIV Infections-overestimated-CD4', 'ASXL1-differ-Primary Myelofibrosis', 'Kidney Failure, Chronic-manage-B2M', 'Kidney Diseases-accumulate-B2M', 'Prostatic Neoplasms-rise-NPEPPS', 'Neoplasms-observed-CEACAM3', 'Neoplasms-found-CALCA', 'APLNR-mediate-Heart Failure', 'Neoplasms-monitored-NPEPPS', 'SLC34A2-consider-Neoplasms', 'SLC34A2-use-Neoplasms', 'UMOD-define-Kidney Diseases', 'Neoplasms-mediate-TF', 'SPG11-become-Paraplegia', 'HIV Infections-use-CD4', 'Neoplasms-represent-TP53', 'GH1-associated-Fractures, Bone', 'Fractures, Bone-associated-GH1', 'GH1-mitigate-Fractures, Bone', 'GH1-lead-Fractures, Bone', 'TP53-introduce-Neoplasms', 'CD19-expressed-Hodgkin Disease', 'PHB1-possess-Neoplasms', 'TP63-show-Hypoxia', 'Heart Arrest-activate-TP53', 'EZH2-show-Neoplasms', 'CFTR-consist-Weight Gain', 'CTSL-contribute-Neoplasms', 'BAK1-result-Death', 'URI1-decreased-Heart Failure', 'Hyperglycemia-result-ALB', 'CFTR-associated-Multiple Organ Failure', 'Multiple Organ Failure-associated-CFTR', 'CD4-observed-Dyslipidemias', 'CD4-worsen-Dyslipidemias', 'HSPA8-expressed-Papilledema', 'MAPT-exacerbate-Neurodegenerative Diseases', 'ESR1-receive-Breast Neoplasms', 'INS-emerge-Diabetes Mellitus', 'FOLH1-show-Neoplasm Metastasis', 'AKT1-activated-Breast Neoplasms', 'TNF-lead-Autoimmune Diseases', 'Arthritis, Rheumatoid-favored-TNF', 'NPEPPS-predict-Neoplasms', 'PTH-cause-Calcinosis', 'Hepatitis C-result-IL7R', 'Infections-considered-IL7R', 'Jaw Diseases-induced-TNFSF11', 'CD4-remain-Acquired Immunodeficiency Syndrome', 'CXCL16-improve-Arthritis, Rheumatoid', 'Diabetes Mellitus, Type 1-result-INS', 'PTPN11-contribute-Leukemia, Myelomonocytic, Juvenile', 'EGFR-found-Neoplasm Metastasis', 'Brain Diseases-present-EPO', 'AMH-increased-Polycystic Ovary Syndrome', 'EPO-considered-Anemia', 'Genetic Diseases, Inborn-linked-HFE', 'VDR-exert-Fractures, Bone', 'APOE-used-Death', 'Prostatic Neoplasms-derive-KLK3', 'VPS13B-lead-Brain Diseases', 'Neoplasms-exhibit-ERBB2', 'MECP2-result-Rett Syndrome', 'INS-specialise-Diabetes Mellitus', 'Infections-required-EGFR', 'Heart Arrest-exhibit-CDKN2A', 'CDC25A-reactivate-Heart Arrest', 'IP6K3-inhibit-Glucose Metabolism Disorders', 'Neoplasms-associated-ARID1A', 'ARID1A-associated-Neoplasms', 'Death-occur-NF2', 'Endometriosis-assess-AMH', 'IFNA1-display-Leukemia, Hairy Cell', 'HTT-destabilize-Neurodegenerative Diseases', 'HTT-trigger-Neurodegenerative Diseases', 'Glioma-express-NODAL', 'BRAF-define-Melanoma', 'ADAM22-validated-Neoplasms', 'ADAM22-treat-Brain Diseases', 'Prostatic Neoplasms-mediate-CDKN2B', 'ZFP14-down-regulated-Neoplasms', 'SMN2-underlie-Muscular Atrophy, Spinal', 'SMN2-required-Muscular Atrophy, Spinal', 'SMN2-include-Muscular Atrophy, Spinal', 'Muscular Atrophy, Spinal-caused-SMN2', 'Muscular Atrophy, Spinal-demonstrate-SMN2', 'Machado-Joseph Disease-introduce-ATXN3', 'Hemochromatosis-screen-TF', 'DOCK8-undergo-Infections', 'Machado-Joseph Disease-show-ATXN3', 'Breast Neoplasms-induce-SMAD3', 'Neoplasms-followed-BRAF', 'COMMD1-generate-Lung Neoplasms', 'GFAP-predict-Neoplasms', 'MEN1-encode-Neoplasms', 'GATA3-attenuate-Drug Hypersensitivity', 'Bone Neoplasms-associated-TNFSF11', 'TNFSF11-associated-Bone Neoplasms', 'INS-suffer-Diabetes Mellitus', 'Adenoma-secrete-PRL', 'Pituitary Neoplasms-secrete-PRL', 'IL6-associated-Lupus Erythematosus, Systemic', 'Lupus Erythematosus, Systemic-associated-IL6', 'AMH-replace-Polycystic Ovary Syndrome', 'RPS7-detected-Anemia', 'HRAS-express-Urinary Bladder Neoplasms', 'HRAS-formed-Fibrosarcoma', 'VPS37A-decreased-Breast Neoplasms', 'VPS37A-investigate-Breast Neoplasms', 'VPS37A-use-Breast Neoplasms', 'VPS37A-promote-Breast Neoplasms', 'GGH-used-Dwarfism, Pituitary', 'Neoplasms-carried-NFE2L2', 'TSPO-present-Alzheimer Disease', 'Hypoglycemia-lapse-INS', 'TSPO-involved-Inflammation', 'INS-considered-Diabetes Mellitus, Type 1', 'Tauopathies-distinguish-MAPT', 'MPO-evoke-Mitochondrial Diseases', 'CRH-compare-Ovarian Neoplasms', 'CRH-control-Ovarian Diseases', 'CRH-synthesized-Ovarian Neoplasms', 'Irritable Bowel Syndrome-inhibit-USP28', 'SLC6A6-identified-Neoplasms', 'SLC6A6-used-Neoplasms', 'SLC6A6-treat-Neoplasms', 'ITIH5-validated-Carcinoma, Pancreatic Ductal', 'Carcinoma, Pancreatic Ductal-correlate-ITIH5', 'Hepatitis B-approved-GPT', 'INS-associated-Stroke', 'Stroke-associated-INS', 'FASLG-associated-Neoplasm Metastasis', 'Neoplasm Metastasis-associated-FASLG', 'Parkinson Disease, Secondary-related-LRRK2', 'Muscular Dystrophy, Duchenne-restore-DMD', 'KL-correlated-Ovarian Neoplasms', 'KL-detected-Ovarian Neoplasms', 'KL-considered-Ovarian Neoplasms', 'Prostatic Neoplasms-performed-GNRH1', 'DEAF1-over-expressing-Lung Neoplasms', 'Lung Neoplasms-over-expressed-DEAF1', 'SIRT3-attenuate-Drug-Related Side Effects and Adverse Reactions', 'ARHGAP24-involved-Breast Neoplasms', 'CDKN2A-implicated-Heart Arrest', 'Pelizaeus-Merzbacher Disease-caused-PLP1', 'TERT-study-Neoplasms', 'VEGFA-identify-Ocular Hypertension', 'DDN-prevent-Glomerulonephritis', 'Cystic Fibrosis-imply-CFTR', 'AP2B1-base-Hepatomegaly', 'PPIA-downregulated-Amyotrophic Lateral Sclerosis', 'AP2B1-aimed-Myocardial Infarction', 'AP2B1-treat-Myocardial Infarction', 'Cystic Fibrosis-harbor-CFTR', 'HDAC9-control-Atherosclerosis', 'EPO-demand-Anemia', 'HIV Infections-change-CD4', 'IFNA1-recognized-Infections', 'Alzheimer Disease-measure-MAPT', 'Motor Neuron Disease-observed-MAPT', 'Spinocerebellar Ataxias-express-ATXN1', 'SMN2-retained-Muscular Atrophy, Spinal', 'Neoplasms-limit-STAG2', 'Neoplasms-contribute-STAG2', 'Diabetes Mellitus-perform-INS', 'CBX7-examine-Neoplasms', 'PLIN2-include-Multiple Myeloma', 'CSF3R-descend-Leukemia, Myeloid, Acute', 'Death-influence-AFP', 'HBP1-include-Neoplasms', 'HP-confirm-Hemolysis', 'AVP-act-Pain', 'Pain-exhibit-AVP', 'AIDS-Related Complex-share-VPS33B', 'WIPI1-enhance-Radial Neuropathy', 'WIPI1-migrate-Radial Neuropathy', 'CA9-expressed-Lung Neoplasms', 'MAGEA10-represent-Neoplasms', 'MAGEA10-expressed-Neoplasms', 'GH1-consider-Pituitary Diseases', 'KL-reported-Neoplasms', 'PARP1-demonstrate-Death', 'INS-linked-Parasitic Diseases', 'AKT1-drive-Infections', 'IGF1-ingest-Infections', 'TRPC3-examine-Nervous System Diseases', 'IDUA-progress-Blindness', 'AMH-measure-Anemia, Sickle Cell', 'IDUA-prevent-Blindness', 'IDUA-associated-Blindness', 'Blindness-associated-IDUA', 'IDUA-investigated-Blindness', 'ALB-identified-Neutropenia', 'SIRT3-restore-Fibrosis', 'SIRT3-subjected-Lung Injury', 'PIEZO1-trigger-Edema', 'ARSA-reported-Leukodystrophy, Metachromatic', 'CD4-stratified-Drug-Related Side Effects and Adverse Reactions', 'VDR-prevent-Mitochondrial Diseases', 'AXL-involved-Neoplasms', 'AXL-make-Neoplasms', 'MAPT-indicated-Alzheimer Disease', 'Hyperthyroidism-cause-REN', 'TNF-injected-Neoplasms', 'SOD1-rescue-Death', 'Liver Neoplasms-injected-SOD1', 'Acromegaly-evolve-GHR', 'Thyroid Cancer, Papillary-use-SIRT6', 'Thyroid Cancer, Papillary-used-SIRT6', 'SIRT6-upregulated-Thyroid Cancer, Papillary', 'SIRT6-enhance-Thyroid Cancer, Papillary', 'APOE-cause-Neurodegenerative Diseases', 'SMN1-used-Muscular Atrophy, Spinal', 'AFP-detect-Carcinoma, Hepatocellular', 'TGFA-induce-Heart Arrest', 'KLK3-develop-Neoplasm Metastasis', 'Heredodegenerative Disorders, Nervous System-mitigate-NPC1', 'SOD1-develop-Intestinal Pseudo-Obstruction', 'CD248-regarded-Neoplasms', 'Pulmonary Fibrosis-seen-TERT', 'TERT-described-Idiopathic Pulmonary Fibrosis', 'Pulmonary Fibrosis-associated-TERT', 'TERT-associated-Pulmonary Fibrosis', 'TERT-demonstrate-Death', 'NME1-suppress-Neoplasm Metastasis', 'NME1-used-Neoplasms', 'NXPH2-used-Neoplasms', 'NXPH2-identify-Neoplasms', 'TP53-contain-Infections', 'Leukemia, Myelomonocytic, Juvenile-display-JAK2', 'MTOR-decrease-Arbovirus Infections', 'SIRT1-play-Pain', 'Mandibular Nerve Injuries-decreased-SIRT1', 'SIRT1-abolish-Pain', 'SIRT1-related-Pain', 'EPO-prevent-Anemia', 'Bone Diseases-exist-PTH', 'INS-decrease-Weight Loss', 'Cardiovascular Diseases-improve-INS', 'Alzheimer Disease-based-APOE', 'BCL6-activated-Hodgkin Disease', 'SLC2A3-delay-Huntington Disease', 'ITPA-protect-Anemia', 'Glioblastoma-cause-EGFR', 'Anemia-become-EPO', 'SLC12A2-used-Seizures', 'SLC12A2-treat-Seizures', 'COA7-identify-Pain Insensitivity, Congenital', 'Neoplasms-correlate-VEGFA', 'HTT-cause-Genetic Diseases, Inborn', 'INS-modulate-HIV Infections', 'Drug-Related Side Effects and Adverse Reactions-associated-EGFR', 'EGFR-associated-Drug-Related Side Effects and Adverse Reactions', 'Neoplasms-stimulated-HGF', 'FBN1-lead-Marfan Syndrome', 'FOXO3-show-Heart Diseases', 'HGF-dysregulated-Neoplasms', 'Muscular Dystrophies-caused-LAMA2', 'DOP1B-participate-Intellectual Disability', 'Neurotoxicity Syndromes-attributed-SOD1', 'DAPK2-modulate-Death', 'CD4-reduce-HIV Infections', 'HLA-DRB1-performed-Hepatitis, Autoimmune', 'L1CAM-play-Fasciculation', 'ELN-include-Aneurysm', 'SPP1-assess-Osteosarcoma', 'SPP1-induce-Osteogenesis Imperfecta', 'Colorectal Neoplasms-analysed-TP53', 'SORL1-affect-Alzheimer Disease', 'Neoplasms-fail-TP53', 'Neoplasms-express-TP53', 'TP53-determine-Colorectal Neoplasms', 'Neoplasms-stratified-TP53', 'Esophageal Squamous Cell Carcinoma-acetylate-KAT2B', 'KAT2B-generated-Esophageal Squamous Cell Carcinoma', 'Esophageal Squamous Cell Carcinoma-increased-KAT2B', 'ATXN2-linked-Genetic Diseases, X-Linked', 'Breast Neoplasms-take-ERBB2', 'ERBB2-confer-Breast Neoplasms', 'GDNF-decrease-Amyotrophic Lateral Sclerosis', 'ZPR1-develop-Muscular Atrophy, Spinal', 'IFNL3-associated-Liver Failure', 'Liver Failure-associated-IFNL3', 'F2R-foreseen-Carcinoma, Hepatocellular', 'Cardiovascular Diseases-conclude-NFE2L2', 'F2R-affect-Carcinoma, Hepatocellular', 'IL7-subjected-Bone Diseases', 'KL-decrease-Adenoma', 'KL-performed-Adenoma', 'SOD1-develop-Communicable Diseases', 'INS-lifesaving-Diabetes Mellitus, Type 1', 'TAT-include-HIV Infections', 'TARDBP-identified-Amyotrophic Lateral Sclerosis', 'INS-discontinue-Diabetes Mellitus', 'PLA2G6-cause-Neurodegenerative Diseases', 'MYC-exploited-Tauopathies', 'Leigh Disease-screened-SLC19A3', 'TP53-play-Heart Arrest', 'KLK3-make-Neoplasms', 'AR-shown-Prostatic Neoplasms', 'Obesity-enrolled-HMGB1', 'CD4-enriched-Multiple Sclerosis', 'Myositis Ossificans-associated-ACVR1', 'ACVR1-associated-Myositis Ossificans', 'UVRAG-identify-Neoplasms', 'Diabetes Mellitus, Type 2-required-INS', 'SIRT1-treat-Alzheimer Disease', 'SUPV3L1-observed-Breast Neoplasms', 'SUPV3L1-lead-Neoplasms', 'HAS2-increase-Fibrosarcoma', 'E4F1-overexpressed-Leukemia, Myeloid, Acute', 'Neoplasms-given-TP53', 'Neoplasms-exhibit-TP53', 'Kidney Neoplasms-gain-TNFSF10', 'Neoplasms-alter-TP53', 'DKK3-associated-Albuminuria', 'Albuminuria-associated-DKK3', 'Adenocarcinoma-identify-NUPR1', 'XPC-associated-Neoplasms', 'Neoplasms-associated-XPC', 'CCR5-decrease-Inflammation', 'Epidermolysis Bullosa Dystrophica-caused-COL7A1', 'BST2-compare-Astrocytoma', 'BST2-upregulated-Astrocytoma', 'BST2-expressed-Brain Neoplasms', 'BST2-play-Brain Neoplasms', 'BST2-increase-Brain Neoplasms', 'Neoplasms-compare-NF1', 'Neoplasms-display-NF1', 'BDNF-regulate-Hypothalamic Neoplasms', 'MTCH2-knock-Heart Diseases', 'Cardiomyopathies-identify-MTCH2', 'Rheumatoid Vasculitis-associated-TNF', 'TNF-associated-Rheumatoid Vasculitis', 'Rheumatoid Vasculitis-treat-TNF', 'Kidney Diseases-assessed-ALPP', 'NPEPPS-selected-Prostatic Neoplasms', 'ABCC3-overexpressed-Carcinoma, Pancreatic Ductal', 'ABCC3-identify-Carcinoma, Pancreatic Ductal', 'Drug-Related Side Effects and Adverse Reactions-result-MTOR', 'ABCC3-reduce-Pancreatic Neoplasms', 'Neoplasms-sustain-PARP1', 'Acromegaly-include-SST', 'Acromegaly-result-GH1', 'IFNA1-assess-Hepatitis C, Chronic', 'IFNA1-compare-Hepatitis C, Chronic', 'NF1-develop-Neurofibrosarcoma', 'AR-contribute-Prostatic Hyperplasia', 'MAPT-characterize-Tauopathies', 'SMN2-mitigate-Muscular Atrophy, Spinal', 'SMN1-lead-Muscular Atrophy, Spinal', 'Hemochromatosis-measure-TF', 'NR3C1-control-Cushing Syndrome', 'Neoplasms-associated-TERF2', 'TERF2-associated-Neoplasms', 'TERF2-estimate-Neoplasms', 'Inflammation-result-INS', 'COL3A1-diagnosed-Ehlers-Danlos Syndrome', 'KIT-found-Leukemia, Myeloid', 'KLK3-influence-Prostatic Hyperplasia', 'MAPT-play-Dementia', 'TTR-cause-Neurodegenerative Diseases', 'NUAK2-slow-Neoplasms', 'NUAK2-evaluate-Prostatic Neoplasms', 'NUAK2-represent-Prostatic Neoplasms', 'INS-compared-Diabetes Mellitus', 'AMH-considered-Endometriosis', 'AMH-seem-Endometriosis', 'INS-adjusted-Diabetes Mellitus', 'INS-differ-Diabetes Mellitus', 'Mastocytosis, Systemic-found-KIT', 'TERT-introduce-Lung Diseases', 'Hypertension-facilitate-AGT', 'KL-decrease-Heart Diseases', 'TNFRSF12A-confined-Glioma', 'KL-favor-Atherosclerosis', 'Genetic Diseases, Inborn-diagnosed-CFTR', 'VEGFA-suppressed-Disease Progression', 'Thalassemia-cooperate-PRDX2', 'SIRT1-involved-Heart Arrest', 'Leukemia, Lymphocytic, Chronic, B-Cell-appear-MDM2', 'Hyperbilirubinemia-linked-ERLIN1', 'Diabetes Mellitus-reduce-INS', 'UCP2-become-Aneurysm', 'Neoplasms-display-EGFR', 'GDAP1-associated-Paralysis', 'Paralysis-associated-GDAP1', 'VCAM1-proposed-Cardiovascular Diseases', 'OLFM4-used-Uterine Diseases', 'Neoplasms-confine-KLK3', 'CD4-result-Acquired Immunodeficiency Syndrome', 'Neoplasm Metastasis-develop-CSE1L', 'SIRPA-provide-Neoplasms', 'CSE1L-compared-Neoplasm Metastasis', 'Neoplasm Metastasis-stain-CSE1L', 'Death-show-CSE1L', 'TP53-express-Neoplasms', 'RUNX2-enhance-Neoplasms', 'MAPT-compare-Movement Disorders', 'MAPT-show-Movement Disorders', 'MAPT-display-Movement Disorders', 'Anaphylaxis-take-ACE', 'Cardiovascular Diseases-shown-ACE', 'INS-affected-Diabetes Mellitus', 'CD48-show-Neoplasms', 'Marfan Syndrome-detect-FBN1', 'Obesity-impair-INS', 'SNAI1-detect-Neoplasms', 'TNFRSF11B-targeting-Pulmonary Arterial Hypertension', 'ADIPOQ-treated-Obesity', 'Neoplasms-affect-INS', 'MTMR2-promote-Stomach Neoplasms', 'CDKN2A-mutated-Melanoma', 'Melanoma-mutated-CDKN2A', 'Muscular Atrophy, Spinal-related-SMN2', 'Hyperglycemia-lead-ALB', 'ELAVL1-play-Heart Arrest', 'SMN2-increase-Muscular Atrophy, Spinal', 'SLC6A5-cause-Stiff-Person Syndrome', 'SLC6A5-encode-Stiff-Person Syndrome', 'Heart Arrest-expected-CDKN2A', 'SOD1-found-Liver Neoplasms', 'INS-lowering-Hypoglycemia', 'ERBB3-target-Neoplasms', 'ERBB3-engage-Neoplasms', 'Liver Neoplasms-possess-SOD1', 'Neoplasms-produce-ERBB3', 'Huntington Disease-seen-HTT', 'KIT-driven-Neoplasms', 'Ossification of Posterior Longitudinal Ligament-occur-MAPT', 'Thromboembolism-do-F8', 'ASH1L-repress-Thyroid Carcinoma, Anaplastic', 'MUC16-found-Cystadenocarcinoma, Serous', 'ITPR2-detected-Amyotrophic Lateral Sclerosis', 'Neoplasms-increased-MUC16', 'DUSP6-associated-Death', 'Death-associated-DUSP6', 'Alzheimer Disease-exhibit-CSTB', 'BMPR2-contribute-Pulmonary Arterial Hypertension', 'FBN1-place-Marfan Syndrome', 'SENP1-observe-Leukemia, Promyelocytic, Acute', 'KLF8-identify-Ovarian Neoplasms', 'Myelodysplastic Syndromes-treat-EPO', 'NLRP1-measure-Colorectal Neoplasms', 'NLRP1-play-Autoimmune Diseases', 'Inflammation-produce-INS', 'Diabetes Mellitus, Type 2-center-INS', 'Alzheimer Disease-depend-APOE', 'COPS2-protect-Neoplasms', 'Infections-revealed-LINC01194', 'Osteosarcoma-shown-MIR195', 'PCA3-include-Prostatic Neoplasms', 'Prostatic Neoplasms-use-PCA3', 'Dyskeratosis Congenita-increase-TERC', 'MEG3-downregulated-Osteoarthritis', 'MIR21-reported-Neoplasms', 'TERC-exhibit-Neoplasms', 'Neoplasms-combined-MT-TD', 'PCA3-complement-Prostatic Neoplasms', 'Starch-fermented-Fatty Acids, Volatile', 'Sodium Dodecyl Sulfate-miss-Glucose', 'Glucose-involved-Fatty Acids', 'Epoprostenol-confer-Heparin', 'Epoprostenol-confer-Hemorrhage', 'Glucosamine-extend-Neoplasms', 'Valproic Acid-extend-Neoplasms', 'Cardiotoxicity-increase-Doxorubicin', 'Octreotide-cause-Glucose', 'rs63751438-fail-Heparin', 'rs63751438-form-Heparin', 'Thromboembolism-receive-Heparin', 'Glucose-prime-Death', 'Glycosphingolipids-lead-Ependymoma', 'Sepharose-form-Neoplasms', 'Nucleosides-found-Neurodegenerative Diseases', 'Glucose-reserved-Diabetes Mellitus', 'Glucose-sense-Diabetes Mellitus', 'Heparin, Low-Molecular-Weight-prevent-Thromboembolism', 'Glucose-maintained-Hepatitis B', 'Digoxin-protect-Retinal Degeneration', 'Polysaccharides-supplemented-Salmonella Infections', 'Amyotrophic Lateral Sclerosis-employ-Keratan Sulfate', 'Glucose-linked-Death', 'Glucose-protect-Reperfusion Injury', 'Keratan Sulfate-become-Weight Loss', 'Keratan Sulfate-detected-Amyotrophic Lateral Sclerosis', 'Keratan Sulfate-play-Amyotrophic Lateral Sclerosis', 'Cystic Fibrosis-consist-Tobramycin', 'Neoplasms-observed-Glucose', 'Lysosomal Storage Diseases-lead-Gangliosides', 'Tobramycin-demonstrate-Cystic Fibrosis', 'Infections-cleared-Tobramycin', 'Tobramycin-combine-Cystic Fibrosis', 'Shock-related-Glucose', 'Cardiotoxicity-cause-Anthracyclines', 'Fructosamine-confirm-Diabetes Mellitus', 'Diabetes Mellitus-performed-Fructosamine', 'Glucose-modulate-Huntington Disease', 'Heparin-established-Venous Thromboembolism', 'Multiple Organ Failure-divided-Heparin', 'Diabetes Mellitus-improve-Glucose', 'Hypoglycemia-ameliorate-Glucose', 'Ovarian Neoplasms-isolated-Doxorubicin', 'Hemorrhage-observed-Tinzaparin', 'Fructose-present-Obesity', 'Doxorubicin-given-Hemangiosarcoma', 'Obesity-confer-Glucose', 'Glucose-differ-Death', 'Death-receive-Heparin', 'Diabetes Mellitus-keep-Glucose', 'Heparin-compare-Death', 'Heparin-demonstrate-Death', 'Glucose-show-Atrial Fibrillation', 'Glucose-observed-Atrial Fibrillation', 'Fondaparinux-make-Venous Thromboembolism', 'Fabry Disease-result-Glycosphingolipids', 'Acute Lung Injury-induced-Lipopolysaccharides', 'Drug-Related Side Effects and Adverse Reactions-determined-Etoposide', 'Glucose-caused-Kidney Diseases', 'Ascorbic Acid-involved-Head and Neck Neoplasms', 'Psychosine-reduce-Demyelinating Diseases', 'Anthracyclines-occur-Heart Failure', 'Doxorubicin-alleviate-Cardiotoxicity', 'Lactose-lead-Fractures, Bone', 'Ascorbic Acid-decrease-Neoplasms', 'Doxorubicin-produce-Cardiotoxicity', 'Bleomycin-compare-Pleural Effusion, Malignant', 'Tobramycin-formulated-Pseudomonas Infections', 'Ceramides-reduce-Neurodegenerative Diseases', 'Ceramides-suppress-Neurodegenerative Diseases', 'Acarbose-given-Diabetes Mellitus', 'Fluorodeoxyglucose F18-show-Infections', 'Neoplasms-grow-Agar', 'Kidney Diseases-associated-Aminoglycosides', 'Aminoglycosides-associated-Kidney Diseases', 'Prostatic Neoplasms, Castration-Resistant-exist-Doxorubicin', 'Glucose-identify-Nervous System Diseases', 'Diabetes Mellitus-motivate-Glucose', 'Periodontitis-induced-Lipopolysaccharides', 'Diabetes Mellitus-found-Glucose', 'Diabetes Mellitus-vary-Glucose', 'Disseminated Intravascular Coagulation-receive-Heparin', 'Glucose-highlighted-Diabetes Mellitus', 'Cardiomyopathies-receive-Doxorubicin', 'Glucose-evaluated-Diabetes Mellitus', 'Doxorubicin-used-Carcinoma, Hepatocellular', 'Lysosomal Storage Diseases-catalyze-Glycosaminoglycans', 'Kidney Diseases-induced-Doxorubicin', 'Hyaluronic Acid-improve-Pain', 'Nucleosides-approved-Hepatitis B', 'Glycosaminoglycans-cause-Growth Disorders', 'Diabetes Mellitus, Type 2-define-Glucose', 'Hemophilia A-include-Heparin', 'Heparin, Low-Molecular-Weight-investigated-Venous Thromboembolism', 'Enoxaparin-achieve-Venous Thromboembolism', 'Metabolic Diseases-constitute-Glucose', 'Etoposide-tolerated-Carcinoma, Non-Small-Cell Lung', 'Neoplasms-involve-Ascorbic Acid', 'TDP-43 Proteinopathies-find-Glucose', 'Gaucher Disease-considered-Glucosylceramides', 'Sugars-caused-TDP-43 Proteinopathies', 'Anthracyclines-receive-Drug-Related Side Effects and Adverse Reactions', 'Amyotrophic Lateral Sclerosis-suggest-Glucose', 'Fructosamine-establish-Glucosephosphate Dehydrogenase Deficiency', 'Amikacin-act-Lymphadenitis', 'Glucose-transplant-Diabetes Mellitus', 'Heparin, Low-Molecular-Weight-improve-Neoplasms', 'Heparin, Low-Molecular-Weight-tend-Neoplasms', 'Gaucher Disease-cause-Glucosylceramides', 'Muscular Diseases-associated-Glycogen', 'Glycogen-associated-Muscular Diseases', 'Topiramate-follow-Death', 'Diabetic Nephropathies-based-Glucose', 'Doxorubicin-result-Drug-Related Side Effects and Adverse Reactions', 'Doxorubicin-monitor-Neoplasms', 'Cardiotoxicity-shown-Doxorubicin', 'Glucose-associated-Acute Kidney Injury', 'Acute Kidney Injury-associated-Glucose', 'Neoplasms-made-Streptozocin', 'HIV Infections-comprise-Nucleosides', 'Pancreatic Neoplasms-receive-Streptozocin', 'Glucose-compared-Diabetes Mellitus', 'Glucose-keep-Diabetes Mellitus', 'Heart Arrest-followed-Glucose', 'Glucose-undergo-Heart Arrest', 'Sepharose-form-Sarcoma', 'Glucose-monitor-Neoplasms', 'Topiramate-controlled-Psychoses, Substance-Induced', 'Ginsenosides-exert-Myotonic Dystrophy', 'Sepsis-cleared-Polysaccharides', 'Ginsenosides-improve-Myotonic Dystrophy', 'Acarbose-reduce-Diabetes Mellitus', 'Amikacin-identify-Drug-Related Side Effects and Adverse Reactions', 'Genetic Diseases, Inborn-hydrolyze-Glycogen', 'Glucose-increase-Hypertrophy', 'Diabetic Nephropathies-fed-Sucrose', 'Hyaluronic Acid-associated-Infections', 'Infections-associated-Hyaluronic Acid', 'Lymphoma, B-Cell-undergo-Anthracyclines', 'Lymphoma, Non-Hodgkin-include-Doxorubicin', 'Neoplasms-compare-Doxorubicin', 'Glucose-suspend-Diabetes Mellitus', 'Enoxaparin-initiated-Venous Thromboembolism', 'Hemorrhage-occur-Nadroparin', 'Neoplasms-contain-Anthracyclines', 'Hemorrhage-reduced-Heparin, Low-Molecular-Weight', 'Glycosaminoglycans-caused-Metabolism, Inborn Errors', 'Agar-appear-Cystic Fibrosis', 'Agar-used-Infections', 'Agar-distinguish-Infections', 'Glucose Intolerance-diagnosed-Glucose', 'Doxorubicin-show-Glioma', 'Metabolic Syndrome-differ-Glucose', 'Nucleosides-include-Neoplasms', 'Hemorrhage-undergo-Heparin', 'Glucose-performed-Pancreatic Neoplasms', 'Glucose-establish-Hemorrhage', 'Doxorubicin-involve-Neoplasms', 'Anthracyclines-evaluate-Breast Neoplasms', 'Glucose-underestimate-Critical Illness', 'Mycophenolic Acid-used-Graft vs Host Disease', 'Aspartame-decrease-Lipofuscin', 'Cyclosporine-used-Graft vs Host Disease', 'Fatty Acids, Omega-3-affect-Glutathione', 'Coronary Artery Disease-associated-Atazanavir Sulfate', 'Atazanavir Sulfate-associated-Coronary Artery Disease', 'Death-characterized-Infliximab', 'Hemolysis-capture-Phosphatidylserines', 'Fatty Acids, Omega-3-result-Death, Sudden', 'Fatty Acids, Omega-3-concentrate-Death, Sudden', 'Cholesterol-yield-Weight Loss', 'Diabetes Mellitus-prevented-Cholesterol', 'Obesity-required-Thioctic Acid', 'Fatty Acids, Omega-3-exert-Neoplasms', 'Cholesterol-found-Hepatic Insufficiency', 'Eicosapentaenoic Acid-exert-Amyotrophic Lateral Sclerosis', 'Cholesterol-associated-Hypercholesterolemia', 'Hypercholesterolemia-associated-Cholesterol', 'Fatty Acids, Omega-3-reported-Neoplasms', 'Cholesterol-deferred-Coronary Artery Disease', 'Misoprostol-recommended-Gastrointestinal Diseases', 'Hemorrhage-receive-Alprostadil', 'Cholesterol-manage-Hypercholesterolemia', 'Uremia-expose-Phosphatidylserines', 'Cholesterol-play-Arteriosclerosis', 'Diabetes Mellitus-observe-Cholesterol', 'Valproic Acid-inhibit-Depression, Postpartum', 'Myocardial Infarction-characterized-Cholesterol', 'Prostaglandins-considered-Diabetes Mellitus', 'Cholesterol-prevent-Diabetes Mellitus', 'Valproic Acid-slow-Death', 'Dinoprostone-overproduced-Neoplasms', 'Phospholipids-modulate-Leukemia, Myeloid', 'Cholesterol-estimate-Cardiovascular Diseases', 'Epoprostenol-improve-Pulmonary Arterial Hypertension', 'Thromboxanes-facilitate-Cardiovascular Diseases', 'Death-remain-Cholesterol', 'Cholesterol-reduced-Fragile X Syndrome', 'Valproic Acid-continue-Death', 'Cholesterol-report-Hypercholesterolemia', 'Valproic Acid-use-Amyotrophic Lateral Sclerosis', 'Death-correlated-Triglycerides', 'Cholesterol-improve-Neurodegenerative Diseases', 'Obesity-become-Cholesterol', 'Renal Insufficiency, Chronic-induce-Cholesterol', 'Anemia-show-Triglycerides', 'Protein-Energy Malnutrition-provoked-Fatty Acids', 'Death-live-Cholesterol', 'Mycoses-administered-Micafungin', 'Micafungin-found-Death', 'Cholesterol-decrease-Atherosclerosis', 'Epoprostenol-lead-Pulmonary Arterial Hypertension', 'Cholesterol-confirmed-Death', 'Amenorrhea-present-Cholesterol', 'Valproic Acid-include-Muscular Atrophy, Spinal', 'Metabolic Syndrome-adher-Cholesterol', 'Huntington Disease-unaffected-Valproic Acid', 'Capsaicin-exert-Aneurysm', 'Headache Disorders, Secondary-use-Venlafaxine Hydrochloride', 'Obesity-decreased-Triglycerides', 'Triglycerides-promote-Obesity', 'Obesity-increased-Triglycerides', 'Brain Injuries, Traumatic-suggest-Thioctic Acid', 'Cholesterol-come-Cardiovascular Diseases', 'Fatty Acids, Omega-3-prevent-Neurodegenerative Diseases', 'Cholesterol-discovered-Atherosclerosis', 'Oleic Acid-assess-Neoplasms', 'Neoplasms-occur-Oleic Acid', 'Oleic Acid-occur-Neoplasms', 'Sphingolipids-reduce-Pneumonia', 'Triglycerides-showed-Diabetes Mellitus', 'Capsaicin-noticed-Neoplasms', 'Capsaicin-used-Carcinoma, Non-Small-Cell Lung', 'Hypertension-raised-Triglycerides', 'Smith-Lemli-Opitz Syndrome-diagnosed-Cholesterol', 'Valproic Acid-halted-Paralysis', 'Chemical and Drug Induced Liver Injury-decrease-Cholesterol', 'Coronary Artery Disease-lowering-Plant Oils', 'Butyric Acid-reinforce-Neoplasms', 'Cholesterol-delay-Neurodegenerative Diseases', 'Dinoprostone-associated-Colorectal Neoplasms', 'Colorectal Neoplasms-associated-Dinoprostone', 'Cholesterol-show-Coronary Artery Disease', 'Sphingolipids-interfere-Cystic Fibrosis', 'Cystic Fibrosis-provide-Glutathione', 'Atazanavir Sulfate-associated-Kidney Diseases', 'Kidney Diseases-associated-Atazanavir Sulfate', 'Teriparatide-decrease-Fractures, Bone', 'Heart Failure-use-Cyclosporine', 'Glutathione-lead-Drug-Related Side Effects and Adverse Reactions', 'Octreotide-report-Death', 'Graft vs Host Disease-consist-Cyclosporine', 'Glutathione-overexpressed-Hemolytic-Uremic Syndrome', 'Abnormalities, Drug-Induced-improve-Glutathione', 'Drug-Related Side Effects and Adverse Reactions-induced-Glutathione', 'Octreotide-decrease-Acromegaly', 'Teriparatide-increase-Fractures, Bone', 'Octreotide-studied-Acromegaly', 'Ghrelin-used-Cachexia', 'Cystinosis-enhance-Glutathione', 'Cyclosporine-prevent-Infections', 'Heart Valve Diseases-occur-Octreotide', 'Heart Failure-treated-Cyclosporine', 'Hyperoxia-induce-Glutathione', 'Glutathione-used-Neoplasms', 'Teriparatide-sustain-Fractures, Stress', 'Cyclosporine-lead-Kidney Diseases', 'Dyslipidemias-based-Atazanavir Sulfate', 'Dyslipidemias-compare-Atazanavir Sulfate', 'Octreotide-used-Carcinoid Tumor', 'Cyclosporine-counteract-Muscle Weakness', 'Cyclosporine-slow-Muscular Diseases', 'Thyrotropin-live-Cardiovascular Diseases', 'Cyclosporine-accompanied-Kidney Diseases', 'Cyclosporine-prevent-Heart Diseases', 'Exenatide-represent-Diabetes Mellitus', 'Enalapril-project-Stroke', 'Leuprolide-elevate-Heart Diseases', 'Trimethoprim, Sulfamethoxazole Drug Combination-dominate-Pneumonia, Pneumocystis', 'Leuprolide-increase-Heart Diseases', 'Leuprolide-cause-Heart Diseases', 'Prostatic Neoplasms-prevent-Denosumab', 'Neoplasms-amplify-Ipilimumab', 'Rituximab-associated-Hypotension', 'Hypotension-associated-Rituximab', 'Rituximab-represent-Leukemia, Lymphocytic, Chronic, B-Cell', 'Crack Cocaine-incorporated-HIV Infections', 'Trastuzumab-overcome-Drug-Related Side Effects and Adverse Reactions', 'Neoplasms-treated-Cetuximab', 'Cetuximab-achieve-Lung Neoplasms', 'Bevacizumab-warranted-Cardiovascular Diseases', 'Rituximab-resemble-Arthritis, Rheumatoid', 'Anemia-increase-Infliximab', 'Rituximab-exhibit-Cardiotoxicity', 'Heart Diseases-incur-Trastuzumab', 'Dehydration-follow-Infliximab', 'Denosumab-prevent-Breast Neoplasms', 'Astrocytoma-recur-Bevacizumab', 'Infliximab-alleviate-Headache Disorders, Secondary', 'Melanoma-undergo-Nivolumab', 'Stomach Neoplasms-treated-Trastuzumab', 'Lymphoma-used-Rituximab', 'Retinal Vein Occlusion-respond-Bevacizumab', 'rs1409112179-exhibit-Retinal Degeneration', 'Aflatoxins-recognized-Carcinoma, Hepatocellular', 'Aflatoxins-affect-HIV Infections', 'rs121908033-modulated-Hypertrophy', 'rs869312966-identified-Seizures', 'rs869312966-accompany-Seizures', 'rs121913514-lead-Leukemia, Myeloid, Acute', 'Glioma-harbour-rs113488022', 'rs63751438-fail-Neurodegenerative Diseases', 'rs6313-associated-Aneurysm', 'Aneurysm-associated-rs6313', 'rs1390860312-exhibit-Neurodegenerative Diseases', 'Neoplasms-associated-rs77375493', 'rs77375493-associated-Neoplasms', 'rs132630304-develop-Muscular Atrophy', 'rs147750704-lead-Ape Diseases', 'Drug-Related Side Effects and Adverse Reactions-caused-rs193922916', 'rs104893736-associated-Cataract', 'Cataract-associated-rs104893736', 'Arrhythmias, Cardiac-investigate-rs120074195', 'Arrhythmias, Cardiac-associated-rs120074195', 'rs120074195-associated-Arrhythmias, Cardiac', 'rs120074195-incorporated-Arrhythmias, Cardiac', 'rs104893736-cause-Cataract', 'rs606231296-associate-Lupus Erythematosus, Systemic', 'Lupus Erythematosus, Systemic-associate-rs606231296', 'Atherosclerosis-assessed-Cardiovascular Diseases', 'Atherosclerosis-assessed-Atrial Fibrillation', 'Atherosclerosis-assessed-Death', 'IL6-assessed-Cardiovascular Diseases', 'IL6-assessed-Atrial Fibrillation', 'IL6-assessed-Death', 'IL18-assessed-Cardiovascular Diseases', 'IL18-assessed-Atrial Fibrillation', 'IL18-assessed-Death', 'Leukoencephalopathies-associated-RSPO3', 'RSPO3-associated-Leukoencephalopathies', 'IL18-associated-Cardiovascular Diseases', 'Cardiovascular Diseases-associated-IL18', 'IL18-associated-Death', 'Death-associated-IL18', 'IL15-combine-CD4', 'IL15-combine-HIV Infections', 'TOMM40-associated-APOE', 'APOE-associated-TOMM40', 'CD4-associated-Inflammation', 'Inflammation-associated-CD4', 'Brain Diseases-affect-Glycerophospholipids', 'Alzheimer Disease-affect-Glycerophospholipids', 'Brain Diseases-affect-Sphingolipids', 'Alzheimer Disease-affect-Sphingolipids', 'Brain Diseases-affect-Fatty Acids', 'Cholecystolithiasis-be with-Cholecystitis', 'Cholecystolithiasis-diagnosing-Cholecystitis', 'Cholecystolithiasis-diagnose-Cholecystitis', 'Alzheimer Disease-affect-Fatty Acids', 'Acute Kidney Injury-be in-Sepsis', 'Heparin-compares-Acute Kidney Injury', 'Heparin-compares-Sepsis', 'PAH-cause-Abnormalities, Drug-Induced', 'PAH-cause-Phenylketonurias', 'CRP-detect-Cholecystolithiasis', 'CRP-detect-Cholecystitis', 'Atherosclerosis-promote-Calcinosis', 'Atherosclerosis-promote-Cholesterol', 'Pulmonary Disease, Chronic Obstructive-contribute-Inflammation', 'CD8A-increased-Pulmonary Disease, Chronic Obstructive', 'NPM1-associated-DNMT3A', 'DNMT3A-associated-NPM1', 'CD8A-contribute-Inflammation', 'Cholecystolithiasis-used-CRP', 'Cholecystitis-used-CRP', 'JAG1-downregulated-PIK3CG', 'PDGFC-downregulated-PIK3CG', 'VEGFA-downregulated-PIK3CG', 'PDGFRA-downregulated-PIK3CG', 'FGF2-downregulated-PIK3CG', 'FOS-downregulated-PIK3CG', 'KDR-downregulated-PIK3CG', 'PDGFRB-downregulated-PIK3CG', 'NOTCH2-downregulated-PIK3CG', 'Trans Fatty Acids-include-Fatty Acids', 'Death-seen-Diabetes Mellitus', 'Dementia-be lead cause of-Death', 'Delirium-be prevalent neuropsychiatric syndrome in-Neoplasms', 'Syphilis-be with-Infections', 'HIV Infections-live-Hypertension', 'Pneumonia, Aspiration-causes of-Death', 'Death-increase-Cerebral Hemorrhage', 'Immunologic Deficiency Syndromes-associated-Lung Diseases', 'Lung Diseases-associated-Immunologic Deficiency Syndromes', 'Prostatic Neoplasms-defined-Neoplasm Metastasis', 'Immunologic Deficiency Syndromes-associated-Bronchiectasis', 'Bronchiectasis-associated-Immunologic Deficiency Syndromes', 'Immunologic Deficiency Syndromes-associated-Autoimmune Diseases', 'Autoimmune Diseases-associated-Immunologic Deficiency Syndromes', 'Common Variable Immunodeficiency-associated-Infections', 'Infections-associated-Common Variable Immunodeficiency', 'Bronchiectasis-include-Infections', 'Lung Diseases, Interstitial-include-Infections', 'Autoimmune Diseases-include-Infections', 'Lymphoma-include-Infections', 'Bone Diseases, Metabolic-be prognostic factor in-Neoplasms', 'Bone Diseases, Metabolic-be prognostic factor in-Stomach Neoplasms', 'Bone Diseases, Metabolic-consider-Death', 'Parkinson Disease-demonstrate-Diabetes Mellitus', 'Parkinson Disease-demonstrate-Inflammation', 'Metabolic Syndrome-represent-Cardiovascular Diseases', 'Metabolic Syndrome-represent-Diabetes Mellitus, Type 2', 'Metabolic Syndrome-linked-Neoplasms', 'Alzheimer Disease-exhibit performance in-Ventricular Fibrillation', 'Erectile Dysfunction-defined-Muscle Rigidity', 'Erectile Dysfunction-maintain-Muscle Rigidity', 'Hypothalamic Neoplasms-collected-Hypertension', 'Spondylitis, Ankylosing-associated-Death', 'Death-associated-Spondylitis, Ankylosing', 'Muscular Dystrophy, Duchenne-modify risk of-Hip Fractures', 'Muscular Dystrophy, Duchenne-improve-Hip Fractures', 'Cerebral Small Vessel Diseases-estimate-Thoracic Outlet Syndrome', 'Dementia-estimate-Thoracic Outlet Syndrome', 'Thrombosis-observed-Hemophilia A', 'Thrombosis-observed-Atrial Fibrillation', 'Cardiovascular Diseases-be in-Hemophilia A', 'Erectile Dysfunction-provide-Obesity', 'Sleep Apnea Syndromes-be prevalent in-Idiopathic Pulmonary Fibrosis', 'Cardiovascular Diseases-be significant causes of-Death', 'Breast Neoplasms-be significant causes of-Death', 'Diabetes Mellitus-identify-Postoperative Complications', 'Stroke-predict-Sleep Wake Disorders', 'Femur Head Necrosis-be with-Joint Diseases', 'Chondrosarcoma-be with-Neoplasms', 'Inflammation-base-Skin Diseases', 'Acidosis-associated-Metabolism, Inborn Errors', 'Metabolism, Inborn Errors-associated-Acidosis', 'Neoplasms-include-Nevus, Epithelioid and Spindle Cell', 'Optic Nerve Injuries-be uncommon but devastate cause of-Vision Disorders', 'Nevus, Epithelioid and Spindle Cell-avoid-Melanoma', 'Lung Injury-enable-Seizures', 'Lung Injury-maintain-Seizures', 'Renal Insufficiency, Chronic-explained-Vascular Calcification', 'Vascular Calcification-use-Renal Insufficiency', 'Polymyalgia Rheumatica-present-Pelvic Girdle Pain', 'Rheumatic Fever-present-Pelvic Girdle Pain', 'Death-treated-Neoplasms', 'Lung Diseases-diagnosed-Neoplasms', 'Pulmonary Disease, Chronic Obstructive-diagnosed-Neoplasms', 'Asthma-diagnosed-Neoplasms', 'Sleep Initiation and Maintenance Disorders-start-Leukemia, Myelogenous, Chronic, BCR-ABL Positive', 'Ossification of Posterior Longitudinal Ligament-visualize changes severity in-Stroke', 'Osteoarthritis-experience-Cardiac Output, Low', 'Heart Failure-include-Musculoskeletal Diseases', 'Atherosclerosis-contributor to-Cardiovascular Diseases', 'HIV Infections-Laboratory-Alzheimer Disease', 'Pneumonia-cause-Respiratory Tract Diseases', 'Psychomotor Disorders-reflect-Learning Disabilities', 'Infections-adhere-Death', 'Pain, Postoperative-influence-Lung Neoplasms', 'Multiple Myeloma-ignored-Neoplasms', 'HIV Infections-recognised-Liver Diseases', 'Metabolic Syndrome-hospitalised-Pneumonia', 'Diabetes Mellitus, Type 2-categorize-Osteoporotic Fractures', 'Coronary Artery Disease-characterized-Atherosclerosis', 'Abnormalities, Drug-Induced-result-Hemolysis', 'Pain, Postoperative-improve-Hip Fractures', 'Sarcopenia-suggest-Dementia', 'Communicable Diseases-used-Death', 'Infections-experience-Nervous System Diseases', 'Thromboembolism-cause-Death', 'Thromboembolism-cause-Neoplasms', 'Breast Neoplasms-extend-Neoplasms', 'Squamous Cell Carcinoma of Head and Neck-develop-Neoplasms', 'Cerebral Infarction-described-Infections', 'Arteritis-lead-Vision Disorders', 'Systemic Vasculitis-lead-Vision Disorders', 'Gait Disorders, Neurologic-result-Musculoskeletal Diseases', 'Spinal Injuries-present-Neurologic Manifestations', 'Pain-fail-Failed Back Surgery Syndrome', 'Death-suffer-Cardiovascular Diseases', 'Neoplasms-improve-Fatigue', 'Neoplasms-improve-Sleep Initiation and Maintenance Disorders', 'Hypotension-associated-Sleep Initiation and Maintenance Disorders', 'Sleep Initiation and Maintenance Disorders-associated-Hypotension', 'Hip Fractures-combined-Heart Failure', 'Sepsis-combined-Hip Fractures', 'Sepsis-combined-Heart Failure', 'Chediak-Higashi Syndrome-receive-Heart Block', 'Diabetes Mellitus-tend-Peripheral Nervous System Diseases', 'Diabetes Mellitus-present-Peripheral Nervous System Diseases', 'Myelodysplastic Syndromes-associated-Alzheimer Disease', 'Alzheimer Disease-associated-Myelodysplastic Syndromes', 'Vascular Calcification-include-Cardiovascular Diseases', 'Heart Diseases-include-Vascular Calcification', 'Low Back Pain-caused-Osteoporosis', 'Confusion-become-Delirium', 'Confusion-contribute-Death', 'Obesity-arise-Inflammation', 'Obesity-triggered-Inflammation', 'Sarcopenia-show-Obesity', 'Sarcopenia-linked-Death', 'Psoriasis-reduced-Cardiovascular Diseases', 'Cardiovascular Diseases-reduced-Myocardial Infarction', 'Atrial Fibrillation-associated-Frailty', 'Frailty-associated-Atrial Fibrillation', 'Atherosclerosis-understand-Inflammation', 'Breast Neoplasms-contribute-Neoplasms', 'Diabetes Mellitus-observe-Death', 'Hypotension-measured-Myocardial Infarction', 'Pulmonary Disease, Chronic Obstructive-increased-Lung Diseases, Interstitial', 'Cardiovascular Diseases-impact-Death', 'Microcephaly-involve-Genetic Diseases, Inborn', 'Growth Disorders-involve-Genetic Diseases, Inborn', 'Hearing Loss, Central-involve-Genetic Diseases, Inborn', 'Dementia-receive-Cardiovascular Diseases', 'Stroke-recommend-Dementia', 'Paresis-increase-Femoral Neck Fractures', 'Paresis-observed-Joint Dislocations', 'Ischemia-threatening-Hemorrhage', 'Stomach Neoplasms-followed-Death', 'Stomach Neoplasms-followed-Neoplasms', 'Pulmonary Disease, Chronic Obstructive-divided-Sarcopenia', 'Hemorrhage-result-Hemostatic Disorders', 'Huntington Disease-present-Epilepsy', 'Sarcopenia-increase-Pulmonary Disease, Chronic Obstructive', 'Huntington Disease-present-Glucose Metabolism Disorders', 'Neurologic Manifestations-occur-Huntington Disease', 'Deglutition Disorders-identify-Sarcopenia', 'Neoplasms-proposed-Death', 'Neoplasms-proposed-Diabetes Mellitus, Type 2', 'Death-describe-Drug Overdose', 'Meningococcal Infections-caused-Infections', 'Diabetes Mellitus-seen-Constipation', 'Diabetes Mellitus-seen-Signs and Symptoms, Digestive', 'Constipation-seen-Signs and Symptoms, Digestive', 'Constipation-seen-Diabetes Mellitus', 'Constipation-linked-Diabetes Mellitus', 'Learning Disabilities-detect-Diabetes Mellitus', 'Pneumonia-experience-Pneumococcal Infections', 'Prader-Willi Syndrome-combine-Hypothalamic Diseases', 'Prader-Willi Syndrome-combine-Muscle Hypotonia', 'Prader-Willi Syndrome-combine-Hyperphagia', 'Prader-Willi Syndrome-combine-Obesity', 'Hypothalamic Diseases-combine-Obesity', 'Muscle Hypotonia-combine-Obesity', 'Hyperphagia-combine-Obesity', 'Prader-Willi Syndrome-provide-Neoplasms', 'Sleep Initiation and Maintenance Disorders-aggravate-Hypoxia', 'Hypoxia-associated-Hypertension', 'Hypertension-associated-Hypoxia', 'Hypoxia-associated-Stroke', 'Stroke-associated-Hypoxia', 'Phenylketonurias-meet-Death', 'Obesity-characterized-Endocrine System Diseases', 'Obesity-characterized-Congenital Abnormalities', 'FST-constitute-Chalones', 'Arthritis, Rheumatoid-affect-CRP', 'Lung Neoplasms-mediated-CLEC4D', 'Anorexia-give-CCK', 'MSTN-influence-Alzheimer Disease', 'MYCN-used-Neoplasms', 'MSTN-associated-Dementia', 'Dementia-associated-MSTN', 'TTR-suggest-Dementia', 'PTH-observe-Kidney Diseases', 'TOMM40-contribute-Dementia', 'SLC6A3-underlie-Catatonia', 'NOLC1-expressed-Neoplasms', 'NOLC1-overexpressed-Colorectal Neoplasms', 'HIV Infections-increase-CD4', 'Diabetes Mellitus-peak-Glucose', 'Vestibular Diseases-acquire-Aminoglycosides', 'Fatty Acids, Unsaturated-reduce-Coronary Artery Disease', 'Triglycerides-associated-Alzheimer Disease', 'Alzheimer Disease-associated-Triglycerides', 'Parkinson Disease-maintain-Diabetes Mellitus', 'Parkinson Disease-maintain-ALB', 'Parkinson Disease-maintain-CRP', 'SIRT6-affect-INS', 'SIRT6-improve-Glucose', 'Glucose-affect-INS', 'RSPO3-associated-Dementia', 'Dementia-associated-RSPO3', 'CDH5-associated-Dementia', 'Dementia-associated-CDH5', 'Obesity-associated-NFE2L2', 'NFE2L2-associated-Obesity', 'Obesity-associated-SOD1', 'SOD1-associated-Obesity', 'RSPO3-associated-Cerebral Infarction', 'Cerebral Infarction-associated-RSPO3', 'Coronary Artery Disease-assess-IL6', 'Cerebral Infarction-assess-IL6', 'Heart Failure-assess-IL6', 'Stroke-assess-IL6', 'Atrial Fibrillation-assess-IL6', 'Death-assess-IL6', 'Coronary Artery Disease-assess-IL18', 'Cerebral Infarction-assess-IL18', 'Heart Failure-assess-IL18', 'Stroke-assess-IL18', 'Atrial Fibrillation-assess-IL18', 'Death-assess-IL18', 'KLRG1-increased-Pulmonary Disease, Chronic Obstructive', 'Glucose-shunt-Pentoses', 'Glucose-shunt-NOX4', 'Pentoses-up-regulate-NOX4', 'Genetic Diseases, Inborn-caused-CSH2', 'Acromegaly-focus-GH1', 'CXCL10-include-Inflammation', 'NFE2L2-include-Inflammation', 'IL6-associated-GPT', 'GPT-associated-IL6', 'IL6-associated-Hyperuricemia', 'Hyperuricemia-associated-IL6', 'CRP-comprise-TNF', 'Death-comprise-CRP', 'IL1A-associated-Osteoporotic Fractures', 'Osteoporotic Fractures-associated-IL1A', 'CXCL8-associated-Osteoporotic Fractures', 'Osteoporotic Fractures-associated-CXCL8', 'TOMM40-related-Alzheimer Disease', 'NOLC1-associated-MCM10', 'MCM10-associated-NOLC1', 'NOLC1-associated-NOC3L', 'NOC3L-associated-NOLC1', 'NOLC1-associated-HELLS', 'HELLS-associated-NOLC1', 'NOLC1-associated-Colorectal Neoplasms', 'Colorectal Neoplasms-associated-NOLC1', 'NOLC1-regulate-Colorectal Neoplasms', 'NOLC1-associated-Neoplasms', 'Neoplasms-associated-NOLC1', 'NOLC1-regulate-Neoplasms', 'MCM10-regulate-Colorectal Neoplasms', 'Diabetes Mellitus-nullify-Death', 'MCM10-regulate-Neoplasms', 'Stroke-nullify-Death', 'Basal Ganglia Diseases-use-WT1', 'NOC3L-regulate-Colorectal Neoplasms', 'NOC3L-regulate-Neoplasms', 'Glutathione-observe-TFRC', 'HELLS-regulate-Colorectal Neoplasms', 'HELLS-regulate-Neoplasms', 'Basal Ganglia Diseases-use-SIX2', 'Basal Ganglia Diseases-use-SIX1', 'GHR-nullify-Death', 'CDCP1-associated-Alzheimer Disease', 'Alzheimer Disease-associated-CDCP1', 'LTA-associated-Alzheimer Disease', 'Alzheimer Disease-associated-LTA', 'IL12A-regulated-CEBPB', 'IL1B-regulated-CEBPB', 'CTH-retain-TP53', 'CTH-maintain-Glucose Metabolism Disorders', 'TP53-maintain-Glucose Metabolism Disorders', 'CXCL5-regulated-CEBPB', 'SIRT2-activate-CDKN2B', 'STAT3-activate-CDKN2B', 'CXCL8-regulated-CEBPB', 'SIRT2-trigger-Retinal Degeneration', 'STAT3-trigger-Retinal Degeneration', 'IL6-regulated-CEBPB', 'CDKN2B-trigger-Retinal Degeneration', 'CXCL1-regulated-CEBPB', 'CXCL2-regulated-CEBPB', 'Inflammation-regulated-CEBPB', 'APOE-demonstrate-Alzheimer Disease', 'HMGB2-alleviate-Osteoarthritis', 'SOX5-alleviate-Osteoarthritis', 'BAX-associated-Osteoporosis', 'Osteoporosis-associated-BAX', 'CASP8-associated-Osteoporosis', 'Osteoporosis-associated-CASP8', 'CASP9-associated-Osteoporosis', 'Osteoporosis-associated-CASP9', 'CASP3-associated-Osteoporosis', 'Osteoporosis-associated-CASP3', 'TP53-associated-Osteoporosis', 'Osteoporosis-associated-TP53', 'SIRT1-oversee-Death', 'PRKAB1-tied-Death', 'CCN4-oversee-Death', 'Death-tied-EPO', 'Death-tied-APOE', 'Fatty Acids, Unsaturated-improve-Pulmonary Disease, Chronic Obstructive', 'Fatty Acids, Omega-3-improve-Pulmonary Disease, Chronic Obstructive', 'Triglycerides-compare-CFTR', 'Cholesterol-compared-Sarcopenia', 'Triglycerides-compared-Sarcopenia', 'Lung Neoplasms-caused-Lymphoma', 'Lung Neoplasms-caused-EGFR', 'Cardiomyopathy, Dilated-cause-Death, Sudden', 'Cardiomyopathy, Dilated-cause-Lipodystrophy', 'Cardiomyopathy, Dilated-cause-Nervous System Diseases', 'Werner Syndrome-result-INS', 'LMNA-cause-Cardiomyopathy, Dilated', 'Aging, Premature-result-INS', 'LMNA-cause-Death, Sudden', 'CCR1-reduce-Retinal Diseases', 'CCR1-reduce-Inflammation', 'LMNA-cause-Nervous System Diseases', 'Liver Neoplasms-underlie-Amyotrophic Lateral Sclerosis', 'Liver Neoplasms-underlie-KIF5A', 'Alzheimer Disease-result-Neurodegenerative Diseases', 'Mitochondrial Diseases-result-Neurodegenerative Diseases', 'Aneurysm-include-Autoimmune Diseases', 'Neoplasms-include-Autoimmune Diseases', 'Obesity-improve-Fibrosis', 'Fatty Liver-improve-Fibrosis', 'Liver Cirrhosis-improve-Fibrosis', 'Liver Cirrhosis-reduce-Cardiovascular Diseases', 'Fibrosis-improve-Cardiovascular Diseases', 'Fibrosis-improve-Erythema', 'NLRP3-contribute-Glycogen Storage Disease Type II', 'Fibrosis-improve-Glucose', 'HIV Infections-persist-Infections', 'Inflammation-measure-ADIPOQ', 'Metabolic Diseases-measure-ADIPOQ', 'HPS1-rescue-Memory Disorders', 'HPS1-rescue-Neurodegenerative Diseases', 'Inflammation-drive-Pulmonary Disease, Chronic Obstructive', 'Cholesterol-associated-Hepatitis C, Chronic', 'Hepatitis C, Chronic-associated-Cholesterol', 'Fatty Acids-associated-Heart Diseases', 'Heart Diseases-associated-Fatty Acids', 'Fatty Acids-associated-Cerebrovascular Disorders', 'Cerebrovascular Disorders-associated-Fatty Acids', 'Death-posed-Communicable Diseases', 'FOXO3-posed-Communicable Diseases', 'Diabetes Mellitus-protect-Coronary Artery Disease', 'Diabetes Mellitus-improve-Heart Failure', 'Diabetes Mellitus-attenuate-Cerebrovascular Disorders', 'Diabetic Nephropathies-protect-Coronary Artery Disease', 'Diabetic Nephropathies-improve-Heart Failure', 'Diabetic Nephropathies-attenuate-Cerebrovascular Disorders', 'Fatty Liver-protect-Coronary Artery Disease', 'Myocardial Infarction-characterised-Lymphopenia', 'Fatty Liver-improve-Heart Failure', 'Fatty Liver-attenuate-Cerebrovascular Disorders', 'Carcinogenesis-linked-Inflammation', 'Carcinogenesis-promote-Inflammation', 'Coronary Artery Disease-attenuate-Cerebrovascular Disorders', 'Heart Failure-attenuate-Cerebrovascular Disorders', 'Carcinogenesis-linked-Mesothelioma', 'Carcinogenesis-linked-HMGB1', 'Glucose-attenuate-Diabetes Mellitus', 'HMGB1-promote-Mesothelioma', 'Glucose-attenuate-Diabetic Nephropathies', 'Glucose-protect-Coronary Artery Disease', 'Glucose-improve-Heart Failure', 'HMGB1-inhibit-Carcinogenesis', 'Glucose-attenuate-Cerebrovascular Disorders', 'HMGB1-inhibit-Mesothelioma', 'Amyotrophic Lateral Sclerosis-comprise-Neurodegenerative Diseases', 'Amyotrophic Lateral Sclerosis-comprise-TDP-43 Proteinopathies', 'Amyotrophic Lateral Sclerosis-linked-TDP-43 Proteinopathies', 'Nerve Degeneration-include-Dementia', 'Liver Neoplasms-comprise-Neurodegenerative Diseases', 'Liver Neoplasms-comprise-TDP-43 Proteinopathies', 'Dementia-comprise-Neurodegenerative Diseases', 'Dementia-comprise-TDP-43 Proteinopathies', 'Memory Disorders-occur-Nerve Degeneration', 'Neurodegenerative Diseases-linked-TDP-43 Proteinopathies', 'Amyotrophic Lateral Sclerosis-comprise-TARDBP', 'Liver Neoplasms-comprise-TARDBP', 'Dementia-comprise-TARDBP', 'Neurodegenerative Diseases-linked-TARDBP', 'Hypertension-mitigate-FOXO3', 'Inflammation-result-Anemia', 'Diabetes Mellitus-revealed-KL', 'Obesity-revealed-KL', 'Primary Ovarian Insufficiency-include-NLRP3', 'Non-alcoholic Fatty Liver Disease-revealed-KL', 'Polycystic Ovary Syndrome-include-NLRP3', 'Endometriosis-include-NLRP3', 'Obstetric Labor, Premature-include-NLRP3', 'Eclampsia-include-NLRP3', 'Mitochondrial Diseases-result-Fibrosis', 'SLC25A4-contribute-Mitochondrial Diseases', 'SLC25A4-result-Fibrosis', 'Vestibular Diseases-appear-Ototoxicity', 'KL-correlated-Sleep Wake Disorders', 'KL-correlated-Diurnal Enuresis', 'CDKN2A-include-Breast Neoplasms', 'SIRT7-disrupt-Cardiovascular Diseases', 'SIRT7-disrupt-Kidney Diseases', 'SIRT7-disrupt-Inflammation', 'SIRT7-increase-Neoplasms', 'CD4-increase-Neoplasms', 'MSTN-known-FST', 'APOE-targeted-MAPT', 'APOE-control-MAPT', 'DAPK1-targeted-MAPT', 'POU5F1-expressed-NANOG', 'SOX2-expressed-NANOG', 'RUNX1-extend-TAL1', 'GATA3-extend-TAL1', 'MYB-extend-TAL1', 'SIX2-disappear-SIX1', 'GDF15-increase-NLRP3', 'GDF15-increase-SIRT1', 'GDF15-increase-GDF11', 'CDKN2A-encode-TP53', 'LEP-encoded-CDH11', 'CCL11-overexpress-CDKN2A', 'CCL11-overexpress-SERPINE1', 'CEBPB-target-TP73', 'CEBPB-target-MED28', 'CEBPB-target-WSB1', 'CTH-anchor-TP53', 'TP53-attributed-CTH', 'CTH-activate-TP53', 'CTH-maintain-TP53', 'APLN-mediate-APELA', 'CD8A-include-CD4', 'VEGFA-upregulated-TAT', 'SOX5-elevate-HMGB2', 'SOX5-remodeled-HMGB2', 'Multiple Myeloma-accompanied-Acro-Osteolysis', 'Chronic Kidney Disease-Mineral and Bone Disorder-accompanied-Acro-Osteolysis', 'Renal Insufficiency, Chronic-involved-Cardiovascular Diseases', 'Dementia-increase-Hearing Loss', 'Dementia-emerge-Nuchal Cord', 'Obesity-identify-Chronic Disease', 'Fibrosis-arise-Salivary Gland Diseases', 'Fibrosis-arise-Inflammation', 'Fibrosis-arise-Carcinoma, Ductal', 'Fibrosis-arise-Autoimmune Diseases', 'Fibrosis-lead-Atrophy', 'Salivary Gland Diseases-arise-Inflammation', 'Salivary Gland Diseases-arise-Carcinoma, Ductal', 'Salivary Gland Diseases-arise-Autoimmune Diseases', 'Salivary Gland Diseases-lead-Atrophy', 'Inflammation-lead-Atrophy', 'Carcinoma, Ductal-lead-Atrophy', 'Otitis-result-Death', 'Urethral Neoplasms-noted-Desmoplastic Small Round Cell Tumor', 'Alzheimer Disease-remain-Inflammation', 'Ataxia-affected-Obesity', 'Inflammation-exacerbate-Alzheimer Disease', 'Cardiovascular Diseases-contribute-Atrial Fibrillation', 'Dementia-arise-Hearing Loss', 'Neoplasms-brought-Cardiotoxicity', 'Seizures-predict-Cardiovascular Diseases', 'Gliosis-occur-Neurodegenerative Diseases', 'Joint Diseases-associated-Obesity', 'Obesity-associated-Joint Diseases', 'Cardiomyopathy, Dilated-lead-Death, Sudden', 'Fractures, Open-reported-Anhedonia', 'Malnutrition-related-Deglutition Disorders', 'Diabetes Mellitus-offer-Atherosclerosis', 'Diabetes Mellitus-offer-Heart Failure', 'Diabetes Mellitus-offer-Cardiovascular Diseases', 'Anemia-linked-Death', 'Muscle Weakness-improve-Stroke', 'Muscle Weakness-associated-Stroke', 'Stroke-associated-Muscle Weakness', 'Amyotrophic Lateral Sclerosis-develop-Respiratory Tract Infections', 'Liver Neoplasms-develop-Respiratory Tract Infections', 'Neurodegenerative Diseases-develop-Respiratory Tract Infections', 'Death-related-Huntington Disease', 'Death-increase-Huntington Disease', 'Huntington Disease-increase-Parkinson Disease', 'Inflammation-associated-Parkinson Disease', 'Parkinson Disease-associated-Inflammation', 'Hypertension-suffer-Stroke', 'Placenta Diseases-designated-Immune System Diseases', 'Antiphospholipid Syndrome-characterized-Thrombosis', 'Lupus Erythematosus, Systemic-induce-Inflammation', 'Autoimmune Diseases-induce-Inflammation', 'Precancerous Conditions-found-Kidney Diseases', 'Arthritis, Rheumatoid-include-Weight Loss', 'Diabetes Mellitus, Type 2-decrease-Alzheimer Disease', 'Neurodegenerative Diseases-elucidated-Alzheimer Disease', 'Death-play-Myotonic Dystrophy', 'Myalgia-caused-Wounds and Injuries', 'Fatigue-affect-Respiratory Insufficiency', 'Muscular Atrophy, Spinal-lead-Respiratory Insufficiency', 'Genetic Diseases, Inborn-lead-Muscle Weakness', 'Respiratory Tract Infections-develop-Tuberculosis', 'Atrophy-include-Muscular Atrophy', 'Mitochondrial Diseases-include-Muscular Atrophy', 'Mitochondrial Diseases-include-Atrophy', 'Wounds and Injuries-result-Paralysis', 'Neuromuscular Diseases-result-Paralysis', 'Bone Neoplasms-implicate-Dysgeusia', 'Inflammatory Bowel Diseases-disrupt-Colonic Neoplasms', 'Inflammation-alleviate-Inflammatory Bowel Diseases', 'Infections-cause-Lyme Disease', 'Liver Failure-lead-Death', 'Pain-associated-Stroke', 'Stroke-associated-Pain', 'Death-correlated-Diabetes Mellitus', 'Inflammation-lead-Muscular Atrophy', 'Parkinson Disease, Secondary-assess-Death', 'Parkinson Disease-assess-Death', 'Hemophilia A-assess-Joint Diseases', 'Femur Head Necrosis-used-Joint Diseases', 'Joint Diseases-combined-Pain', 'Inflammation-engaged-Arthritis, Rheumatoid', 'Neoplasms-reported-Venous Thromboembolism', 'Melanoma-explained-Neoplasms', 'Movement Disorders-increase-Seizures', 'Movement Disorders-increase-Huntington Disease', 'Seizures-increase-Huntington Disease', 'Hemolytic-Uremic Syndrome-marked-Mitochondrial Diseases', 'Hemolytic-Uremic Syndrome-marked-Inflammation', 'Hemolytic-Uremic Syndrome-marked-Dysbiosis', 'Myotonic Dystrophy-associated-Dementia', 'Dementia-associated-Myotonic Dystrophy', 'Diabetes Mellitus-develop-Foot Ulcer', 'Tibial Neuropathy-associated-Pain', 'Pain-associated-Tibial Neuropathy', 'Femoral Neuropathy-associated-Pain', 'Pain-associated-Femoral Neuropathy', 'Diabetes Mellitus-maintain-Ulcer', 'HIV Infections-contribute-Neurodegenerative Diseases', 'HIV Infections-contribute-Alzheimer Disease', 'Alzheimer Disease-define-Leukoencephalopathies', 'Liver Diseases-classified-Hypertension', 'Thoracic Outlet Syndrome-linked-Aneurysm', 'Thoracic Outlet Syndrome-linked-Neurodegenerative Diseases', 'Intestinal Diseases-related-Inflammation', 'Retinal Diseases-live-Diabetes Mellitus', 'Urinary Incontinence-report-Cardiac Output, Low', 'Head and Neck Neoplasms-defined-Neoplasms', 'Edema-related-Glycogen Storage Disease Type II', 'Facial Nerve Diseases-related-Glycogen Storage Disease Type II', 'Neoplasms-implicated-Lymphoma, B-Cell', 'Neoplasms-implicated-Multiple Myeloma', 'Adenomatous Polyposis Coli-mediate-Charles Bonnet Syndrome', 'Adenomatous Polyposis Coli-predict-Charles Bonnet Syndrome', 'Parkinson Disease-known-Dyskinesia, Drug-Induced', 'Parkinson Disease-include-Hypokinesia', 'Neurodegenerative Diseases-include-Muscle Rigidity', 'Neurodegenerative Diseases-include-Tremor', 'Neurodegenerative Diseases-include-Dyskinesia, Drug-Induced', 'Neurodegenerative Diseases-include-Hypokinesia', 'Jaw Diseases-resolved-Hypotension', 'Fractures, Bone-undertake-Obesity', 'Fractures, Bone-include-Sarcopenia', 'Pulmonary Disease, Chronic Obstructive-trail-Cardiovascular Diseases', 'Pulmonary Disease, Chronic Obstructive-trail-Neoplasms', 'Death-trail-Cardiovascular Diseases', 'Death-trail-Neoplasms', 'Kidney Diseases-related-Death', 'Death-correlate-Lung Neoplasms', 'Anorexia-related-Inflammation', 'Pain-reduce-Cardiovascular Diseases', 'Pain-reduce-Fatigue', 'Cardiac Output, Low-report-Vertigo', 'Obesity-linked-Diabetes Mellitus', 'Osteoporosis-assess-Sarcopenia', 'Osteoporosis-assess-Obesity', 'Hyperplasia-lead-Stomach Neoplasms', 'Neoplasms-lead-Stomach Neoplasms', 'Pleural Diseases-affect-Lung Neoplasms', 'Infections-subjected-Stomach Diseases', 'Dyspnea-experience-Headache Disorders, Secondary', 'Dyspnea-experience-Cough', 'Dysbiosis-contribute-Nerve Degeneration', 'Multiple Organ Failure-associated-Delirium', 'Delirium-associated-Multiple Organ Failure', 'Chronic Disease-associated-Alzheimer Disease', 'Alzheimer Disease-associated-Chronic Disease', 'Fractures, Bone-aid-Bone Diseases', 'Death-increasing-Infections', 'Pain-measured-Dyspnea', 'Stroke-spend-Cardiovascular Diseases', 'Stroke-spend-Malocclusion', 'Cardiovascular Diseases-spend-Malocclusion', 'Coronary Artery Disease-attributed-Death', 'Heart Failure-include-Atherosclerosis', 'Sarcopenia-remain-Pain', 'Alzheimer Disease-associated-Myotonic Dystrophy', 'Myotonic Dystrophy-associated-Alzheimer Disease', 'Carcinoma, Hepatocellular-represent-Death', 'Urinary Bladder Calculi-seen-Prostatic Hyperplasia', 'Bone Diseases-resemble-Atherosclerosis', 'Bone Diseases-resemble-Progeria', 'Death, Sudden-adjudicated-Arrhythmias, Cardiac', 'Death, Sudden-adjudicated-Drug Overdose', 'Death, Sudden-contribute-Death', 'Obesity-contribute-Glaucoma', 'Dysbiosis-affect-Glaucoma', 'Breast Neoplasms-lead-Death', 'Inflammation-result-Metabolic Diseases', 'Chronic Disease-complicate-Parkinson Disease', 'Abnormalities, Drug-Induced-characterized-Hypoadrenocorticism, Familial', 'Abnormalities, Drug-Induced-characterized-Amenorrhea', 'Neoplasms-evaluated-Atrial Fibrillation', 'Soft Tissue Neoplasms-include-Neoplasms', 'Atrial Fibrillation-followed-Esophageal Neoplasms', 'Neoplasms-followed-Leukemia', 'Neoplasms-followed-Esophageal Neoplasms', 'Lung Neoplasms-followed-Leukemia', 'Lung Neoplasms-followed-Esophageal Neoplasms', 'Neoplasms-observed-Thyroid Neoplasms', 'Pain Insensitivity, Congenital-undergo-Lung Neoplasms', 'Inflammation-lead-Metabolic Syndrome', 'Diabetes Mellitus, Type 2-display-Inflammation', 'Diabetes Mellitus, Type 2-display-Neoplasms', 'Headache-include-Coinfection', 'Myalgia-include-Coinfection', 'Cough-include-Coinfection', 'Fever-include-Coinfection', 'Fatigue-include-Coinfection', 'Paraneoplastic Syndromes-characterized-Keratosis, Seborrheic', 'Neoplasms-characterized-Keratosis, Seborrheic', 'Gastritis-treated-Infections', 'Sarcopenia-reduce-Stroke', 'Sarcopenia-promote-Death', 'Nerve Degeneration-offer-Alzheimer Disease', 'Sarcopenia-base-Stroke', 'Sarcopenia-base-Death', 'Sarcopenia-base-Cerebral Infarction', 'Malnutrition-cause-Atrial Fibrillation', 'Malnutrition-play-Atrial Fibrillation', 'Osteochondritis-evolve-Osteoarthritis', 'Infections-contribute-Pulmonary Fibrosis', 'Neoplasms-put-Cardiovascular Diseases', 'Atherosclerosis-compare-Hyperlipoproteinemia Type II', 'Atherosclerosis-reported-Hyperlipoproteinemia Type II', 'Muscular Dystrophy, Duchenne-predict-Osteoporosis', 'Muscular Dystrophy, Duchenne-predict-Diabetes Mellitus, Type 2', 'Atrophy-manifest-Neurodegenerative Diseases', 'Tauopathies-manifest-Neurodegenerative Diseases', 'Hepatitis C, Chronic-associated-Liver Cirrhosis', 'Liver Cirrhosis-associated-Hepatitis C, Chronic', 'Fibrosis-evaluated-Liver Cirrhosis', 'Myotonic Dystrophy-associated-Rupture', 'Rupture-associated-Myotonic Dystrophy', 'Hypoglycemia-develop-Chemical and Drug Induced Liver Injury', 'Intracranial Arterial Diseases-drive-Cardiovascular Diseases', 'Anemia-estimate-Death', 'Muscular Atrophy-reduce-Liver Neoplasms', 'Glycogen Storage Disease Type II-contribute-Deaf-Blind Disorders', 'Deaf-Blind Disorders-contribute-Porphyria, Acute Intermittent', 'Trisomy-associated-Abnormalities, Drug-Induced', 'Abnormalities, Drug-Induced-associated-Trisomy', 'Drug Hypersensitivity-occur-Genetic Diseases, Inborn', 'Dyspnea-follow-Pain', 'Drug-Related Side Effects and Adverse Reactions-occur-Genetic Diseases, Inborn', 'Pulmonary Embolism-fail-Mastocytosis, Systemic', 'Wilms Tumor-associated-Kidney Diseases', 'Kidney Diseases-associated-Wilms Tumor', 'Cleidocranial Dysplasia-gained-Dementia', 'Cleidocranial Dysplasia-directed-Dementia', 'Fatty Liver-decrease-Liver Cirrhosis', 'Metabolic Syndrome-induce-Mitochondrial Diseases', 'Metabolic Syndrome-induce-Kidney Diseases', 'Pain-need-Heart Block', 'Sarcopenia-associated-Memory Disorders', 'Memory Disorders-associated-Sarcopenia', 'Heart Block-present-Femoral Fractures', 'Renal Insufficiency, Chronic-increase-Glucose Intolerance', 'Neoplasms-categorized-Sarcopenia', 'Neoplasms-related-Sarcopenia', 'Sarcopenia-change-Neoplasms', 'CHARGE Syndrome-measure-Pain', 'Lung Neoplasms-reflected-Death', 'Death-affected-Retinal Detachment', 'Stroke-provide-Pain', 'Autoimmune Diseases-regulate-Hypothyroidism', 'Gaucher Disease-used-Malnutrition', 'Cardiovascular Diseases-confirm-Atherosclerosis', 'Neurodegenerative Diseases-occur-Vaginal Discharge', 'Nervous System Diseases-characterized-Memory Disorders', 'Diabetes Mellitus-associated-Diabetic Ketoacidosis', 'Diabetic Ketoacidosis-associated-Diabetes Mellitus', 'Fractures, Bone-include-Dementia', 'Skin Neoplasms-prevent-Obesity', 'Skin Neoplasms-prevent-Acute Kidney Injury', 'Skin Neoplasms-prevent-Inflammation', 'Neoplasms-carry-Cardiotoxicity', 'Skin Neoplasms-prevent-Parkinson Disease', 'Obesity-prevent-Acute Kidney Injury', 'Acute Kidney Injury-prevent-Inflammation', 'Acute Kidney Injury-prevent-Parkinson Disease', 'Neoplasms-require-Cardiotoxicity', 'Cardiovascular Diseases-prompt-Neoplasms', 'Pneumococcal Infections-lower-Cardiovascular Diseases', 'Pneumococcal Infections-associated-Stroke', 'Stroke-associated-Pneumococcal Infections', 'Pneumococcal Infections-associated-Heart Failure', 'Heart Failure-associated-Pneumococcal Infections', 'Pneumococcal Infections-associated-Coronary Artery Disease', 'Coronary Artery Disease-associated-Pneumococcal Infections', 'Pneumococcal Infections-associated-Myocardial Infarction', 'Myocardial Infarction-associated-Pneumococcal Infections', 'Dry Eye Syndromes-reduce-Psoriasis', 'Heart Arrest-play-Fibrosis', 'Cardiovascular Diseases-assess-Death', 'Wounds and Injuries-see-Neurologic Manifestations', 'Leg Ulcer-associated-Mastocytosis, Systemic', 'Mastocytosis, Systemic-associated-Leg Ulcer', 'Leg Ulcer-underlie-Mastocytosis, Systemic', 'Disease-characterized-Granuloma', 'Tooth Attrition-correlated-Alzheimer Disease', 'Pneumococcal Infections-elicit-Infections', 'Peripheral Arterial Disease-attributed-Obesity', 'Peripheral Arterial Disease-attributed-Diabetes Mellitus', 'Ischemia-pose-Limb Deformities, Congenital', 'Neurodegenerative Diseases-remain-Alzheimer Disease', 'Neurodegenerative Diseases-remain-Parkinson Disease', 'Neurodegenerative Diseases-linked-Infections', 'Neurodegenerative Diseases-related-Bacterial Infections', 'Infections-linked-Alzheimer Disease', 'Infections-linked-Parkinson Disease', 'Bacterial Infections-show-Alzheimer Disease', 'Bacterial Infections-show-Parkinson Disease', 'Osteoarthritis-lead-Arthralgia', 'Infarction-used-Wounds and Injuries', 'Neurodegenerative Diseases-lead-Arthralgia', 'Neurodegenerative Diseases-lead-Pain', 'Progeria-exhibit-Heart Diseases', 'Progeria-related-Cardiomyopathies', 'Progeria-treat-Cardiomyopathies', 'Heart Diseases-treat-Cardiomyopathies', 'Mitochondrial Diseases-occur-Neuromuscular Diseases', 'Adrenoleukodystrophy-contribute-Dementia', 'Cardiomyopathies-predict-Heart Diseases', 'Neck Pain-treat-Joint Diseases', 'Amyloidosis-associated-Encephalitis', 'Encephalitis-associated-Amyloidosis', 'Toothache-decrease-Wounds and Injuries', 'Periodontal Diseases-decrease-Wounds and Injuries', 'Mitochondrial Diseases-linked-Metabolic Diseases', 'Psoriasis-complicated-Metabolic Syndrome', 'Hip Fractures-experienced-Heart Failure', 'Death-forecast-Heart Failure', 'Hip Fractures-combine-Heart Failure', 'Neurodegenerative Diseases-protect-Alzheimer Disease', 'Stroke-result-Diabetes Mellitus', 'Stroke-result-Pneumonia', 'Diabetes Mellitus-result-Pneumonia', 'Hematoma-avoid-Iatrogenic Disease', 'Sialic Acid Storage Disease-avoid-Iatrogenic Disease', 'Respiratory Tract Infections-shaping-Infections', 'Constipation-take-Kidney Diseases', 'Ovarian Diseases-alleviate-Death', 'Hypertension-disappear-Diabetes Mellitus', 'Ascites-caused-Fibrosis', 'Cardiovascular Diseases-define-Neurologic Manifestations', 'Retinal Degeneration-occur-Parkinson Disease', 'Retinal Degeneration-drive-Diabetes Mellitus', 'Parkinson Disease-drive-Diabetes Mellitus', 'Seizures-indicate-Death', 'Death-define-Dementia', 'Death-improve-Dementia', 'Chronic Kidney Disease-Mineral and Bone Disorder-measure-Death', 'Periodontal Diseases-associated-Metabolic Diseases', 'Metabolic Diseases-associated-Periodontal Diseases', 'Periodontal Diseases-reported-Dementia', 'Dental Caries-associated-Metabolic Diseases', 'Metabolic Diseases-associated-Dental Caries', 'Low Back Pain-associated-Sleep Initiation and Maintenance Disorders', 'Sleep Initiation and Maintenance Disorders-associated-Low Back Pain', 'Dental Caries-reported-Dementia', 'Metabolic Diseases-reported-Dementia', 'Hyperlipoproteinemia Type II-associated-Dementia', 'Dementia-associated-Hyperlipoproteinemia Type II', 'Obesity-present-Inflammation', 'Critical Illness-review-Hearing Loss', 'Genetic Diseases, Inborn-prevent-Death, Sudden', 'Heart Arrest-prevent-Death, Sudden', 'Nervous System Diseases-affect-Fractures, Bone', 'Hypertension, Malignant-correlate-Death', 'Renal Insufficiency, Chronic-correlate-Death', 'Death-correlate-Diabetes Mellitus', 'Chronic Disease-lead-Hypertension', 'Neoplasms-derived-Pancreatic Neoplasms', 'Weight Loss-demonstrate-Pain', 'Alzheimer Disease-cause-Metabolic Diseases', 'Alzheimer Disease-cause-Vision Disorders', 'Pancreatic Neoplasms-grow-Neoplasms', 'Adenomatous Polyposis Coli-affect-Inflammation', 'Neoplasms-undergo-Breast Neoplasms', 'Muscular Dystrophies-exert-Muscular Atrophy', 'Muscular Dystrophies-result-Heart Failure', 'Muscular Atrophy-lead-Heart Failure', 'HIV Infections-report-Cardiovascular Diseases', 'Death-support-Obesity', 'Prostatic Neoplasms-maintain-Neoplasms', 'Kidney Diseases-involve-Diabetic Nephropathies', 'Coronary Artery Disease-implicated-Diabetes Mellitus', 'Death-implicated-Diabetes Mellitus', 'Diabetes Mellitus-induce-Kidney Diseases', 'Asthma-experience-Eosinophilia', 'Pulmonary Disease, Chronic Obstructive-experience-Eosinophilia', 'Rheumatic Diseases-include-Inflammation', 'Cold Injury-include-Inflammation', 'Fever-include-Inflammation', 'Pulmonary Disease, Chronic Obstructive-characterized-Cough', 'Ankle Fractures-debilitate-Death', 'Alzheimer Disease-demonstrate-Parkinson Disease', 'HIV Infections-manifest-Inflammation', 'Diabetes Mellitus-recorded-Death', 'Asthma-implemented-Li-Fraumeni Syndrome', 'Inflammation-highlight-Anemia', 'Coronary Artery Disease-account-Cerebrovascular Disorders', 'Cardiovascular Diseases-increase-Atherosclerosis', 'Cardiovascular Diseases-increase-Myocardial Infarction', 'Cardiovascular Diseases-increase-Cardiomegaly', 'Myotonic Dystrophy-pose-Osteoporosis', 'Cardiovascular Diseases-increase-Fibrosis', 'Cardiovascular Diseases-inhibit-Inflammation', 'Sarcopenia-alleviate-Fatty Liver', 'Seizures-represent-Aneurysm', 'Hypertension-reported-Dementia', 'Chemical and Drug Induced Liver Injury-include-Hepatitis B', 'Heat Stroke-lead-Multiple Organ Failure', 'Heat Stroke-lead-Death', 'Pneumonia-develop-Acute Kidney Injury', 'Dyspnea-associated-Signs and Symptoms, Respiratory', 'Signs and Symptoms, Respiratory-associated-Dyspnea', 'Fever-associated-Signs and Symptoms, Respiratory', 'Signs and Symptoms, Respiratory-associated-Fever', 'Respiratory Insufficiency-require-Central Nervous System Neoplasms', 'Pneumonia-suffer-Acute Kidney Injury', 'Pneumonia-experience-Death', 'Acute Kidney Injury-experience-Death', 'Infections-exhibit-Fever', 'Infections-exhibit-Signs and Symptoms, Respiratory', 'Acute Kidney Injury-admitted-Pneumonia', 'Osteoporotic Fractures-treat-Osteoporosis', 'Fractures, Bone-identified-Death', 'Osteochondritis-result-Pain', 'Osteochondritis-result-Osteoarthritis', 'Hypotension, Orthostatic-associate-Cardiovascular Diseases', 'Cardiovascular Diseases-associate-Hypotension, Orthostatic', 'Hypotension, Orthostatic-associate-Death', 'Death-associate-Hypotension, Orthostatic', 'Polycystic Ovary Syndrome-include-Cardiovascular Diseases', 'Primary Ovarian Insufficiency-include-Cardiovascular Diseases', 'Hyperlipoproteinemia Type II-include-Cardiovascular Diseases', 'Dyslipidemias-remain-Death', 'Infections-got-Death', 'Chlamydia Infections-cause-Infections', 'Chlamydia Infections-detected-Alzheimer Disease', 'Nervous System Diseases-account-Dementia', 'Syncope-treated-Hypotension, Orthostatic', 'Infections-lead-Nervous System Diseases', 'Metabolic Diseases-include-Diabetes Mellitus', 'Metabolic Diseases-include-Myotonic Dystrophy', 'Death-play-Neurodegenerative Diseases', 'Zoonoses-cause-Sepsis', 'Dysautonomia, Familial-diagnose-Kidney Diseases', 'Musculoskeletal Diseases-work-Fractures, Bone', 'Musculoskeletal Diseases-cause-Death', 'Ketosis-mitigate-Hyperinsulinism', 'Diabetes Mellitus-experience-Infections', 'Diabetes Mellitus-develop-Pyelonephritis', 'Diabetes Mellitus-develop-Otitis Externa', 'Diabetes Mellitus-develop-Gangrene', 'Pyelonephritis-include-Infections', 'Otitis Externa-include-Infections', 'Gangrene-include-Infections', 'Osteoarthritis-include-Sarcopenia', 'Hypertension-encompass-Cerebrovascular Disorders', 'Coronary Artery Disease-encompass-Cerebrovascular Disorders', 'Stroke-encompass-Cerebrovascular Disorders', 'Fractures, Bone-rated-Hip Fractures', 'Mitochondrial Diseases-exhibit-Ataxia', 'Cerebral Infarction-detected-Atrial Fibrillation', 'Carcinoma, Squamous Cell-develop-Neoplasms', 'Dyslipidemias-receive-Hemorrhage', 'Hyperthyroidism-receive-Hemorrhage', 'Genetic Diseases, Inborn-manifest-Nervous System Diseases', 'Drug-Related Side Effects and Adverse Reactions-generated-Brain Ischemia', 'Nervous System Diseases-treat-Mitochondrial Diseases', 'Myotonic Dystrophy-include-Chronic Disease', 'Chronic Disease-increase-Neoplasms', 'Myotonic Dystrophy-increase-Neoplasms', 'Retinal Telangiectasis-proven-Aneurysm', 'Retinal Telangiectasis-proven-Renal Artery Obstruction', 'Diabetic Foot-associated-Neoplasms', 'Neoplasms-associated-Diabetic Foot', 'Diabetic Foot-related-Neoplasms', 'Diabetic Foot-develop-Neoplasms', 'Parkinson Disease-demonstrate-Infections', 'Heart Diseases-inhibit-Alzheimer Disease', 'Hepatitis, Viral, Human-include-Liver Diseases', 'Neoplasms-tailored-HIV Infections', 'Demyelinating Diseases-understand-Gait Disorders, Neurologic', 'Neurodegenerative Diseases-understand-Gait Disorders, Neurologic', 'Neurodegenerative Diseases-assessed-Ossification of Posterior Longitudinal Ligament', 'Hypotension-support-Heart Failure', 'Pneumonia-stratified-Pneumococcal Infections', 'Pneumonia-receive-Pneumococcal Infections', 'Pneumococcal Infections-aid-Pneumonia', 'Fasciculation-cause-Death', 'Neoplasms-indicated-Weight Loss', 'Prader-Willi Syndrome-pose-Neoplasms', 'Neoplasms-indicated-Paraneoplastic Syndromes', 'Mitochondrial Diseases-result-Aneuploidy', 'Neoplasms-associated-Prader-Willi Syndrome', 'Prader-Willi Syndrome-associated-Neoplasms', 'Aneuploidy-include-Neurologic Manifestations', 'Diabetes Mellitus-estimated-Myoclonic Epilepsies, Progressive', 'Dyspnea-caused-Respiratory Insufficiency', 'Sarcopenia-occur-Diabetes Mellitus', 'Sarcopenia-occur-Fibrosis', 'Sarcopenia-occur-Heart Failure', 'Sarcopenia-occur-Pulmonary Disease, Chronic Obstructive', 'Sarcopenia-occur-Inflammatory Bowel Diseases', 'Sarcopenia-contribute-Muscular Diseases', 'Muscular Diseases-related-Sarcopenia', 'Diabetes Mellitus-contribute-Muscular Diseases', 'Obesity-contribute-Muscular Diseases', 'Neoplasms-contribute-Muscular Diseases', 'Sarcopenia-linked-Fractures, Bone', 'Fibrosis-contribute-Muscular Diseases', 'Heart Failure-contribute-Muscular Diseases', 'Pulmonary Disease, Chronic Obstructive-contribute-Muscular Diseases', 'Inflammatory Bowel Diseases-contribute-Muscular Diseases', 'Phenylketonurias-related-Death', 'CDKN2B-AS1-promote-VEGFA', 'SIRT6-play-Glucose', 'SIRT6-discuss-Glucose', 'Diabetes Mellitus-stimulated-Glucose', 'Ceramides-known-CERS2', 'Ceramides-include-CERS2', 'GH1-associated-Neoplasms', 'Neoplasms-associated-GH1', 'Glucose-associated-Neoplasms', 'Neoplasms-associated-Glucose', 'ELOVL4-contribute-Retinal Diseases', 'Triglycerides-contain-IDO1', 'Cytokines-protect-Nerve Degeneration', 'TRB-code-Receptor-CD3 Complex, Antigen, T-Cell', 'CD8A-linked-Receptor-CD3 Complex, Antigen, T-Cell', 'PSEN1-exhibit-rs63750001', 'FOXO3-associated-rs12212067', 'rs12212067-associated-FOXO3', 'rs7141087-contribute-BEGAIN', 'CFTR-see-Cystic Fibrosis', 'HMGB1-benefit-Mesothelioma', 'FOXO3-caused-Hypoxia', 'HPS1-ameliorate-Neurodegenerative Diseases', 'Death-dampen-FOXO3', 'FOXO3-reduce-Death', 'FOXO3-influence-Death', 'Neoplasms-activate-SIRT1', 'CPT1A-associated-Alzheimer Disease', 'Alzheimer Disease-associated-CPT1A', 'Inflammation-repressed-IL10', 'FOXO3-treat-Neoplasms', 'CD38-elevated-Inflammation', 'CD38-correlate-Inflammation', 'SHBG-prevent-Osteoporosis', 'TNFSF12-associated-Alzheimer Disease', 'Alzheimer Disease-associated-TNFSF12', 'GOLPH3-play-Neoplasms', 'GOLPH3-suppress-Neoplasms', 'Neoplasms-used-GOLPH3', 'INS-assist-Diabetes Mellitus', 'GFAP-differentiate-Dementia', 'RTEL1-provide-Neoplasms', 'Anorexia-induce-CCK', 'MSTN-test-Dementia', 'MSTN-adjusted-Dementia', 'MTOR-activated-Neoplasms', 'Neoplasms-highlight-SUPT5H', 'CFH-encode-Glycogen Storage Disease Type II', 'CCR1-upregulated-Retinal Diseases', 'CCR1-correlated-Retinal Diseases', 'KL-contribute-Neurodegenerative Diseases', 'Adenomatous Polyposis Coli-estimate-CRP', 'GLP1R-used-Diabetes Mellitus', 'HOXA3-associate-Alzheimer Disease', 'Alzheimer Disease-associate-HOXA3', 'SLC22A4-increase-Inflammation', 'GFAP-measure-Gliosis', 'G6PC1-associated-Hypoglycemia', 'Hypoglycemia-associated-G6PC1', 'OSR1-investigate-Neural Tube Defects', 'OSR1-implicated-Infertility, Female', 'KIF5A-associated-Liver Neoplasms', 'Liver Neoplasms-associated-KIF5A', 'KIF5A-identify-Liver Neoplasms', 'KIF5A-lead-Death', 'Liver Neoplasms-induce-KIF5A', 'KIF5A-identified-Liver Neoplasms', 'POLRMT-promote-Neoplasms', 'FOXE1-correlated-Neoplasms', 'Neoplasms-stained-FOXE1', 'Genetic Diseases, Inborn-caused-BLM', 'FOXE1-used-Colorectal Neoplasms', 'TAT-make-Ischemia', 'CRAT-cause-Mitochondrial Diseases', 'SIRT2-increased-Alzheimer Disease', 'SIRT2-increase-Inflammation', 'CEBPB-suggest-Inflammation', 'EGF-include-Neoplasms', 'Skin Neoplasms-activate-NLRP3', 'TNFRSF1A-associated-Anorexia', 'Anorexia-associated-TNFRSF1A', 'GADD45A-associated-Muscle Weakness', 'Muscle Weakness-associated-GADD45A', 'SIRT5-function-Neoplasms', 'SIRT5-develop-Metabolic Diseases', 'SIRT2-ameliorate-Heart Diseases', 'Colorectal Neoplasms-screen-NOLC1', 'NOLC1-lead-Colorectal Neoplasms', 'Dyslipidemias-become-CFTR', 'NOLC1-enhance-Colorectal Neoplasms', 'CDKN2B-AS1-associated-Coronary Artery Disease', 'Coronary Artery Disease-associated-CDKN2B-AS1', 'Obesity-elevated-Glucose', 'Glucose-measured-Diabetes Mellitus', 'Saponins-treat-Low Back Pain', 'Glucose-receive-Arthralgia', 'Glucose-observed-Glucose Metabolism Disorders', 'Enoxaparin-used-Venous Thromboembolism', 'Fatty Acids, Omega-3-manage-Pulmonary Disease, Chronic Obstructive', 'Propionates-precede-Death', 'Fatty Acids, Omega-3-associated-Pulmonary Disease, Chronic Obstructive', 'Pulmonary Disease, Chronic Obstructive-associated-Fatty Acids, Omega-3', 'Fatty Acids, Unsaturated-linked-Neurodegenerative Diseases', 'Fatty Acids-saturated-Death', 'Dinoprostone-boost-Disease', 'Fatty Acids, Unsaturated-reduce-Inflammation', 'Cholesterol-decreased-Amyloidosis', 'Docosahexaenoic Acids-alleviate-Inflammation', 'Triglycerides-associated-Hepatitis C, Chronic', 'Hepatitis C, Chronic-associated-Triglycerides', 'Triglycerides-protect-Dementia', 'Saxitoxin-cause-Drug-Related Side Effects and Adverse Reactions'])
# Specify the nodes to be removed
NodeRemovalList = ['TBX1', 'MIR933', 'Cytidine Monophosphate N-Acetylneuraminic Acid', 'Acetogenins', 'Cytokines', 'Contraceptives, Oral, Combined', 'Antigens, Polyomavirus Transforming', 'Saxitoxin', 'rs80034486', 'rs1556516', 'Disease']
# Remove them from the node list
for node in NodeRemovalList:
if node in nodes.keys():
del nodes[node]
# Remove edges that connect to these nodes. Have to do this one edge at a time
edges_to_remove = []
for edge in edges.keys():
if edges[edge]['source entity'] in NodeRemovalList or edges[edge]['target entity'] in NodeRemovalList:
edges_to_remove.append(edge)
for edge in edges_to_remove:
if edge in edges.keys():
del edges[edge]
print(f"There are {len(nodes)} and {len(edges)} edges")
There are 12246 and 116387 edges
Let’s look at each of these in more detail. First, let’s pick one of the nodes. Let’s print the keys and choose one:
print(list(nodes.keys()))
['MLH1', 'CD4', 'INS', 'MAPT', 'MYC', 'GSR', 'SOD2', 'CRP', 'IL6', 'SIRT1', 'CHGA', 'CFB', 'SKIV2L', 'TNXB', 'FKBPL', 'NOTCH4', 'CFH', 'HTRA1', 'GCG', 'IGF1', 'GH1', 'GHRH', 'WRN', 'NFKB1', 'SHBG', 'PIAS4', 'CCL2', 'RECQL4', 'BLM', 'ALB', 'TNF', 'BCAM', 'CD151', 'GGH', 'FGF23', 'PTH', 'JUNB', 'H2AZ1', 'PAPPA2', 'ELN', 'KIT', 'CSF2', 'VEGFA', 'MYO5A', 'MTOR', 'KLK3', 'AR', 'ACE', 'LMNB1', 'LMNA', 'NUP62', 'ULK1', 'MAP1LC3A', 'PIK3R2', 'IAPP', 'VDR', 'CLPS', 'APOD', 'FERMT2', 'MS4A6A', 'ABCA7', 'SORL1', 'HTT', 'APOB', 'RAF1', 'MAPK3', 'MAPK1', 'MAP2K1', 'MAP2K2', 'CFI', 'SERPINA1', 'IL7', 'KL', 'BECN1', 'NFE2L2', 'SENP7', 'MOB1B', 'CARMIL1', 'PRRC2A', 'TERF2', 'RFWD3', 'PARP1', 'POT1', 'ATM', 'MPHOSPH6', 'PPARGC1A', 'FNDC5', 'BDNF', 'NTRK2', 'CD8A', 'IFITM3', 'TRIM22', 'LY6E', 'IFNAR1', 'CTNNB1', 'APOL1', 'VWF', 'ATR', 'RNF8', 'BRCA1', 'TP53BP1', 'RETN', 'CXCL8', 'IL10', 'IL1B', 'IL13RA2', 'CXCR4', 'POU5F1', 'NANOG', 'IL2', 'APOE', 'NDRG2', 'BACE1', 'GGA3', 'CDK5', 'PIN1', 'STAT3', 'IFNG', 'KCNJ10', 'AGER', 'AVP', 'GPT', 'SLC17A5', 'NEDD8', 'ISG15', 'URM1', 'ATG12', 'GABARAPL1', 'FAU', 'UCP1', 'HIF1A', 'TET2', 'ASXL1', 'RUNX1', 'KMT2A', 'HLA-DRB1', 'NR1I3', 'CCL11', 'TNFSF13B', 'IL12B', 'PLTP', 'CHIT1', 'CXCL10', 'IL1RL2', 'AKT1', 'TP53', 'SOD1', 'IL1A', 'IFNA2', 'SLC6A2', 'TARDBP', 'SST', 'CDH2', 'SPHK1', 'ADA', 'ADAR', 'ADARB1', 'ADARB2', 'ADIPOQ', 'POMC', 'HSP90AA1', 'ERBB2', 'HLA-DQB1', 'KLF4', 'SOX2', 'CDKN2A', 'CDKN2B', 'GPM6A', 'PAK1', 'TTR', 'CLU', 'TRPM2', 'XRCC6', 'XRCC5', 'DBP', 'RUNX1T1', 'MYH11', 'FLT3', 'BGLAP', 'ODC1', 'FOXC2', 'PLIN1', 'PDE10A', 'SIRT3', 'IGFBP2', 'RIPK3', 'TF', 'HSF1', 'SNCA', 'SYNM', 'SI', 'SLC5A2', 'YAP1', 'CFAP97', 'TRPV1', 'CACNA1S', 'REN', 'MPO', 'NR3C1', 'SYK', 'S100A8', 'MMP1', 'EGF', 'PCNA', 'KLF14', 'FHL2', 'AMER3', 'GNPNAT1', 'HLTF', 'C3', 'TH', 'BMP2', 'SMURF2', 'SP7', 'RUNX2', 'EPO', 'CAT', 'FGF5', 'PROM1', 'POSTN', 'PNPLA2', 'NBN', 'MRE11', 'RAD50', 'CASP7', 'XPA', 'BANF1', 'CTC1', 'STN1', 'TEN1', 'BCL2', 'HMOX2', 'HMOX1', 'BRCA2', 'SELL', 'PRKAB1', 'GHR', 'MT-CYB', 'FOXM1', 'HMBS', 'G6PD', 'TLR4', 'ABCA1', 'ADORA2B', 'LGI1', 'ACHE', 'PAPPA', 'GFAP', 'ITGAM', 'SYP', 'BCL2L1', 'FOXO3', 'SKP2', 'SIRT6', 'TJP1', 'OCLN', 'NOS3', 'ASS1', 'LRPPRC', 'CEACAM8', 'POLD1', 'CEACAM3', 'AFP', 'CETP', 'MT-CO1', 'EGR1', 'HDAC1', 'HDAC2', 'HTR2A', 'RECQL', 'RECQL5', 'NPDC1', 'HERC5', 'ADCY9', 'CKM', 'PHOX2A', 'SCD', 'NRBF2', 'NTAN1', 'TNFSF10', 'TNFRSF10B', 'TNFRSF10C', 'TNFRSF10D', 'SHB', 'EGFR', 'FOXO1', 'FOXO4', 'FOXO6', 'FOXN1', 'SMAD2', 'SLC22A4', 'MGMT', 'MSRB2', 'MSRB1', 'MSTN', 'ACTN3', 'RTL8C', 'CDH1', 'CHI3L1', 'KLF9', 'APOA5', 'SCGN', 'PSMD5', 'PSMC2', 'IL4', 'GABRA2', 'HOXA1', 'NEUROD1', 'NEUROD2', 'PGR', 'STK11', 'DNMT3A', 'MB', 'CYGB', 'ANXA5', 'MMP15', 'NBR1', 'MEIS1', 'ZNF521', 'CD163', 'MCAM', 'CD274', 'EREG', 'CST3', 'MFSD11', 'NTRK1', 'IRS2', 'PTEN', 'IFI44', 'PRL', 'TMED2', 'HMGB1', 'TIMP3', 'DEFB4A', 'MYOT', 'CRYAB', 'FLNC', 'BAG3', 'DNAJB6', 'DES', 'FOXP1', 'E2F1', 'CCND1', 'RBP4', 'NAGLU', 'KNG1', 'NPY', 'TAC1', 'LRRK2', 'TAT', 'ALDH2', 'PCSK1', 'PAX4', 'RELA', 'LEP', 'IGH', 'IL18', 'TFEB', 'PSEN1', 'NOS2', 'GPER1', 'ANGPTL4', 'CXCL1', 'TXNIP', 'STS', 'SHC1', 'ABL1', 'APBB1', 'CDX2', 'QRSL1', 'MSH2', 'MSH3', 'MSH6', 'PMS1', 'PMS2', 'SLC9C1', 'DRD1', 'NCAM1', 'TTC12', 'ANKK1', 'DRD2', 'DRD4', 'DRD5', 'SLC2A9', 'ZBTB20', 'RARRES2', 'NPPA', 'GJA1', 'CS', 'TRH', 'SLC2A2', 'GAPDH', 'F7', 'PTPN11', 'NPM1', 'MME', 'PIP5K1C', 'FOXP3', 'RARB', 'DRAM1', 'FGF21', 'FTO', 'SERPINF1', 'CASP3', 'TP63', 'DLAT', 'FIS1', 'NDUFAB1', 'RAD9A', 'PNN', 'JARID2', 'SLC6A4', 'PIGR', 'ID3', 'CTNNBL1', 'CYP19A1', 'AMH', 'MTNR1A', 'MTNR1B', 'HSPA9', 'TRPC6', 'TRPC1', 'IL3', 'IL15', 'NEFL', 'NRGN', 'CD79A', 'PAX5', 'BCL6', 'SOST', 'ITPK1', 'HSPB2', 'AK4', 'IGFBP5', 'EPOR', 'PLA2G7', 'CFTR', 'WRAP53', 'AHR', 'CERS2', 'MT-ND1', 'CDK6', 'CDK2', 'CDKN1A', 'DCTN6', 'CDKN1B', 'APOA1', 'LPL', 'MTHFR', 'CBS', 'HFE', 'GCLC', 'GSS', 'SERPINI1', 'TYR', 'PNPLA6', 'SIRT2', 'XRCC4', 'NOTCH1', 'CDC42', 'L1CAM', 'TRDMT1', 'CGB5', 'LHB', 'HCAR2', 'GRM7', 'CASR', 'PRAMEF2', 'SELP', 'CASP14', 'KRTAP13-3', 'ALPP', 'POU1F1', 'MSX2', 'SIRT5', 'SIRT7', 'IL1RN', 'C9orf72', 'PRRT2', 'SERPINE1', 'COL1A1', 'NGF', 'LRP1', 'MDM2', 'TGFA', 'PIK3R1', 'SLBP', 'FGFR3', 'DOT1L', 'TREH', 'RGS2', 'IGF1R', 'IGF2R', 'MKX', 'GSN', 'IGF2', 'PTGDR2', 'PTGDS', 'TERT', 'COL1A2', 'CYP24A1', 'KEAP1', 'SMAD7', 'FMR1', 'GSTM1', 'AQP4', 'CCK', 'FBN2', 'ANXA1', 'HGF', 'GDE1', 'TEX101', 'ECM1', 'LDHC', 'PLAUR', 'SLC23A2', 'INHA', 'RAB7B', 'CD9', 'AZGP1', 'SERPINA3', 'FURIN', 'NGFR', 'PF4', 'PPBP', 'GP6', 'GP1BA', 'LYZ', 'ROMO1', 'CXCL9', 'CCL5', 'ADCY4', 'USP7', 'EP300', 'LAMP1', 'SCN5A', 'ENTPD1', 'DCTN1', 'EDNRA', 'FCGR2B', 'VCL', 'PTK2', 'XIAP', 'DIABLO', 'PPIA', 'BSG', 'SAFB', 'MAPK8', 'RYR1', 'SLC12A3', 'TRA2B', 'SLC18A2', 'HCN4', 'ROCK2', 'ROCK1', 'GLIPR2', 'GLB1', 'GALC', 'VDAC1', 'MX1', 'STAT1', 'PML', 'IRF1', 'IRF7', 'IL20', 'IL24', 'JAK1', 'RGN', 'NLRP3', 'CASP1', 'HBB', 'POLB', 'C4A', 'PARK7', 'PINK1', 'UCP2', 'UCP3', 'IDUA', 'HK1', 'BCAR1', 'PXN', 'TNFAIP1', 'BAX', 'METTL3', 'METTL14', 'TNFRSF11B', 'A2M', 'SOX5', 'GSDMC', 'H2AX', 'HDAC9', 'EPHA2', 'EFNA1', 'TOMM40', 'MLC1', 'HMGA2', 'CDC25A', 'BRIP1', 'DDX11', 'COL6A1', 'KRT19', 'AHRR', 'F2RL3', 'MYD88', 'LCN2', 'UGT1A', 'UGT3A1', 'BCHE', 'IGFBP3', 'DAPK3', 'ADM', 'NAMPT', 'CSF1', 'STIL', 'CCN2', 'FGFR1', 'PRKAA2', 'ZMPSTE24', 'CSF3', 'AIF1', 'ABCB1', 'CBX1', 'CBX3', 'SUV39H1', 'SUV39H2', 'CBX2', 'CBX4', 'CBX6', 'CBX7', 'CBX8', 'SUZ12', 'EED', 'EZH1', 'EZH2', 'PCGF1', 'PCGF2', 'PCGF3', 'BMI1', 'PCGF5', 'PCGF6', 'PHC1', 'PHC2', 'PHC3', 'RING1', 'RNF2', 'DPP4', 'MMP9', 'MDK', 'RAD51', 'CTH', 'RAB27A', 'SHH', 'PLS3', 'SLC29A1', 'WNT1', 'LRP5', 'LCT', 'RHO', 'COMT', 'PPARG', 'SLC1A3', 'SLC1A2', 'SLC1A1', 'EEF1E1', 'NOTCH3', 'TRIP13', 'PLA2R1', 'VCP', 'ERCC6', 'CSH1', 'TNNT3', 'RRM2B', 'SIRT4', 'PEG3', 'PLK2', 'GCK', 'EOMES', 'TBX21', 'HLA-A', 'GLP1R', 'F8', 'CREM', 'NPEPPS', 'CREBBP', 'JPH3', 'CKB', 'CXCL13', 'THBS2', 'ACE2', 'EBP', 'GRN', 'PSAP', 'THBD', 'PDPN', 'IL6R', 'CXCL2', 'MAP3K5', 'MAPK9', 'NFKB2', 'CHEK2', 'THOC1', 'NR1H4', 'IL23A', 'ATP6V0A2', 'B2M', 'GRIA1', 'OGG1', 'FASN', 'SRSF2', 'SF3B1', 'ADAM10', 'RHOA', 'SPP1', 'HOXA9', 'FOS', 'CD46', 'CDA', 'APC', 'ABO', 'MYB', 'SLC6A3', 'MIB1', 'CRYL1', 'CISD1', 'CISD2', 'NAF1', 'CISD3', 'MGP', 'TERF1', 'ACAT1', 'ACAT2', 'ACTA1', 'VIM', 'CXCR2', 'CXCR1', 'AQP3', 'DEDD', 'SMAD4', 'CCL26', 'THBS1', 'CYP2D6', 'GDF15', 'CYP2C19', 'ESR1', 'ESRRA', 'MUC16', 'CEL', 'LOX', 'AVEN', 'DLL4', 'DLL1', 'CD248', 'PLXDC1', 'ANTXR1', 'BBC3', 'PTP4A3', 'PDPK1', 'ERCC8', 'ERCC3', 'ERCC4', 'ERCC1', 'LEO1', 'TNNT1', 'NR3C2', 'MTR', 'CAV1', 'GPR39', 'HSPA1A', 'MAPK14', 'CX3CL1', 'CTCF', 'PIK3CA', 'MMP28', 'PON1', 'KCNJ11', 'TPO', 'LPA', 'EML4', 'ALK', 'ANP32B', 'FCRL4', 'TLR9', 'TXNRD1', 'GSTZ1', 'NRF1', 'TFAM', 'PTX3', 'MYOD1', 'CPS1', 'ITGA2B', 'PDE4C', 'MUC1', 'GDF11', 'MBP', 'MT1B', 'HRNR', 'FZD1', 'FZD7', 'FGF17', 'TSPO', 'CYP27A1', 'CYP46A1', 'ABCG1', 'CCR5', 'CXCL12', 'CD5', 'CHRNA3', 'INSL3', 'RXFP2', 'XPC', 'GAST', 'CUBN', 'AMN', 'MTRR', 'CCL24', 'LOXL1', 'DNMT1', 'SCT', 'CYP2C9', 'GBA3', 'KITLG', 'IL11', 'MAD2L1', 'CDC20', 'PTTG1', 'ESPL1', 'HAND2', 'CD22', 'NCL', 'FASLG', 'SCX', 'TNMD', 'BGN', 'DCN', 'DSP', 'C1S', 'ICAM1', 'HSPA1B', 'HSPA1L', 'PRKAA1', 'EEF2', 'PCSK9', 'BFSP1', 'BFSP2', 'HEBP1', 'CCN1', 'JUN', 'CALR', 'CNR1', 'NDUFS4', 'POLG', 'ARMS2', 'FOXA1', 'LAMA5', 'ZNF716', 'ARHGEF10', 'TOR2A', 'SH2D3C', 'CLEC4M', 'RPL10A', 'SERPINB2', 'ALKBH1', 'TGFB1', 'CHAT', 'DUSP22', 'PPP2CA', 'ATF3', 'RCAN1', 'DYRK1A', 'GRK5', 'ETS2', 'TXN', 'GLRX', 'DNM1L', 'PRKN', 'ARID4B', 'GPX1', 'ERBB4', 'BTBD9', 'MAP2K5', 'SKOR1', 'BABAM2', 'ABRA', 'CEMIP', 'DIAPH1', 'HBEGF', 'HOXC13', 'SATB1', 'TNFRSF1B', 'CA4', 'CA1', 'IGFBP4', 'TMPRSS11A', 'PER2', 'SLTM', 'ACVR2B', 'FST', 'DNAJC5B', 'TLR3', 'TLR7', 'CD86', 'CD14', 'GZMB', 'ACBD3', 'SLC16A8', 'IER3', 'GATA2', 'CEBPA', 'SRP72', 'TLR2', 'NOD2', 'DNTT', 'SLC34A1', 'PHEX', 'SMAD3', 'FLG', 'VIP', 'RORA', 'GDNF', 'CDH13', 'SFRP1', 'P2RX7', 'SLC16A12', 'DPYS', 'TUSC3', 'MYO3A', 'SOX11', 'RPS14', 'PCSK6', 'JAK2', 'STAT5A', 'STAT5B', 'GAD1', 'CDR2', 'PSEN2', 'PPARA', 'DLG4', 'DLG3', 'PDGFRB', 'IL17A', 'PHOX2B', 'DBH', 'FANCD2', 'FBLN5', 'SOD3', 'TNFRSF4', 'TNFRSF9', 'REST', 'HSPB1', 'CYP1A2', 'CYP3A5', 'CDK4', 'CENPA', 'PLK1', 'SCO2', 'PAEP', 'ELANE', 'CTSG', 'SLPI', 'SRSF1', 'EWSR1', 'FLI1', 'AURKC', 'BUB1', 'BUB1B', 'CDK1', 'CHEK1', 'FYN', 'POLR3A', 'IDO1', 'TP73', 'COL17A1', 'KPNA4', 'SRP9', 'CCR2', 'STMN1', 'EPHA1', 'KIF2C', 'MCM2', 'MCM3', 'MCM4', 'MCM6', 'MCM7', 'MCM5', 'MITF', 'NFKBIA', 'SRF', 'STRAP', 'NKX2-5', 'CCR7', 'TG', 'STATH', 'DIRAS3', 'DDX4', 'GSTP1', 'GIP', 'CLOCK', 'NPPC', 'FOXK2', 'GNRH1', 'GLUL', 'CTSD', 'PTGS2', 'MT-CO2', 'EPHX1', 'INSR', 'LYPLA1', 'CP', 'AP2B1', 'IFNA1', 'NOX4', 'EIF2AK3', 'CLSTN1', 'PRF1', 'PTN', 'APOC1', 'ARNTL', 'NOS1', 'KAT6B', 'MORF4L1', 'MORF4L2', 'THPO', 'CYP2A6', 'CYP2E1', 'C19orf48', 'MVP', 'RBMX', 'ADRB2', 'GPX4', 'IKBKG', 'MAP3K7', 'UBE2N', 'UBE2V1', 'HNF4A', 'GBA', 'CD200', 'CD200R1', 'CXCL5', 'NLRC5', 'VRK2', 'GPR6', 'GNG4', 'KCNQ2', 'CYP3A4', 'HRAS', 'KRAS', 'NRAS', 'POLD3', 'LEPR', 'YY1', 'SREBF2', 'EIF2S1', 'LRRC34', 'CAMK4', 'HAUS3', 'PICALM', 'TAC3', 'PLEKHG4', 'CCDC88A', 'TGFBR2', 'BAMBI', 'SLC25A14', 'MUC5AC', 'FGF7', 'CRH', 'ARID1A', 'FGFR2', 'IL17RB', 'CXCL14', 'PPP3CA', 'DDIT4', 'BNIP3', 'ABCG2', 'GLO1', 'NCOA3', 'IL16', 'AOPEP', 'S100B', 'MAP2', 'GAP43', 'MMP14', 'PRKCA', 'BAK1', 'RHOT1', 'CLN3', 'RPS6KB1', 'FSTL1', 'SCGB1D4', 'CD19', 'NR1I2', 'NTM', 'CALB1', 'MARCKS', 'VSIG4', 'TFAP2A', 'SP1', 'NOX1', 'CYBB', 'NOX3', 'NOX5', 'PAX7', 'HCN1', 'NPC1', 'NPC2', 'UBC', 'GLS', 'KCNA1', 'IL5', 'RPS12', 'BICD1', 'HSPD1', 'OPN4', 'SEMA4B', 'POLK', 'CD109', 'PLAC1', 'TRIB3', 'DNASE1', 'VSNL1', 'CHP1', 'SQSTM1', 'SV2A', 'SLC17A7', 'ZNF763', 'CCN4', 'GSTM5', 'PVALB', 'CALB2', 'TNFSF11', 'SLC26A9', 'RNASE3', 'PSMD11', 'PSMB3', 'PSMB5', 'PSMB6', 'SOX9', 'ACAN', 'DKK1', 'OXT', 'CCNB1', 'CCNE1', 'TPP2', 'MYBBP1A', 'LDLR', 'WDR36', 'PGP', 'HS3ST4', 'JUND', 'LORICRIN', 'AGTR1', 'VEGFC', 'GLRX3', 'GMPS', 'ING1', 'MAP3K4', 'MT1G', 'ERCC5', 'EMD', 'IDE', 'NEDD4', 'CUL7', 'OBSL1', 'CCDC8', 'PER3', 'HSPA8', 'SPHK2', 'SLC22A1', 'SLC29A4', 'ITGAX', 'CCR1', 'ANG', 'FDPS', 'ATP6V1B2', 'NTHL1', 'IFIT1', 'IFIT2', 'IFITM1', 'CHKA', 'ITGAL', 'SPRY2', 'CBL', 'SRD5A2', 'PTK7', 'PGC', 'LIF', 'SDC4', 'CD276', 'CD80', 'TNKS', 'FAF1', 'CDC34', 'IRS1', 'NOP10', 'NHP2', 'GAR1', 'F2R', 'LIN28B', 'MCM8', 'TMEM18', 'RXRG', 'FHIT', 'WT1', 'HCRT', 'STAR', 'RARA', 'RXRA', 'NEU1', 'NEU3', 'NEU4', 'IL13', 'SLC3A1', 'TLR1', 'MAOB', 'MAOA', 'GSTK1', 'CDH5', 'SNAP25', 'CYP2J2', 'DDAH1', 'MED23', 'ARG1', 'AGXT2', 'PDE1A', 'PDE1C', 'PIEZO2', 'CILP', 'SNAP23', 'STXBP1', 'ISYNA1', 'ADAMTS4', 'SMPD2', 'ERBB3', 'CYP1A1', 'ELK3', 'SPARC', 'ROR2', 'COG2', 'CLUL1', 'TMCO1', 'SIX1', 'SIX6', 'GAS7', 'ATOH7', 'CD40LG', 'CALCA', 'BMPR1B', 'TFPI', 'MERTK', 'AXL', 'OXTR', 'NQO1', 'MMP2', 'KAT2B', 'CYP11B2', 'FCGR1A', 'EDN1', 'FLCN', 'HK2', 'DUOX2', 'NXF1', 'PHB2', 'CERS6', 'CERS5', 'FUT2', 'FTL', 'OPA1', 'UTRN', 'OMA1', 'PLIN2', 'PLIN5', 'GLRX2', 'OTC', 'WNT3A', 'BHMT', 'EHMT2', 'PRMT8', 'BAG5', 'ACTB', 'HPRT1', 'GUSB', 'ERCC2', 'CDK7', 'SRSF3', 'PIAS1', 'SYN3', 'USP14', 'COL3A1', 'RB1CC1', 'GATA6', 'SFTPB', 'DKK3', 'EIF2AK2', 'EXO1', 'PRDX3', 'PRX', 'PTK2B', 'ELAVL1', 'XPO1', 'CARM1', 'TEK', 'MFN2', 'ATG5', 'ATG7', 'AHSG', 'BIRC5', 'CDCA8', 'IL7R', 'FN1', 'SLC6A1', 'SLC4A1', 'CDH11', 'PTHLH', 'RNF138', 'RBBP8', 'SERPINE2', 'CYCS', 'SETBP1', 'FAT4', 'ARIH1', 'DNAH2', 'CSMD1', 'CDK12', 'ABCC1', 'CETN1', 'CTSK', 'WWC1', 'CLSTN2', 'ZC3H12A', 'ATP7B', 'COMP', 'BRAF', 'IMMP2L', 'GPD2', 'AIFM1', 'IL9', 'GTF2H5', 'IER2', 'LAG3', 'PDCD1', 'EBF1', 'OTOL1', 'NCR3', 'NCR1', 'KIR2DL4', 'KLRK1', 'GNB3', 'LRRC23', 'NPAS2', 'HP', 'HPX', 'NDUFB3', 'RRAD', 'KDR', 'RAB32', 'RHOT2', 'MFGE8', 'HSF2', 'RAD51C', 'RAD52', 'MUTYH', 'POLL', 'PDK1', 'SREBF1', 'SGK1', 'VEGFB', 'CTSC', 'CDKN1C', 'KLKB1', 'TSPAN18', 'NCOA1', 'NT5C3B', 'MIP', 'HLA-E', 'ROM1', 'TTK', 'CTLA4', 'RIPK1', 'HDAC4', 'HDAC5', 'HDAC6', 'HDAC7', 'HDAC8', 'HDAC11', 'MCM3AP', 'CLEC11A', 'PKD1', 'PKD2', 'PRKCSH', 'SEC63', 'VTN', 'FBLN1', 'EFEMP1', 'TAS2R38', 'SMARCA4', 'MFN1', 'ATXN3', 'SUMO1', 'MT2A', 'RUVBL1', 'RUVBL2', 'GADD45G', 'SETD2', 'XDH', 'ALG14', 'FADS1', 'FADS2', 'LPGAT1', 'GCKR', 'PKD2L1', 'HBA1', 'LRP2', 'PYCR1', 'POLH', 'EZR', 'TAFAZZIN', 'SIGLEC8', 'IL21', 'FGF9', 'ETFA', 'S100A12', 'CACNA1G', 'RUNX3', 'IGFBP7', 'RASSF2', 'CXCR5', 'C1QA', 'CD38', 'CX3CR1', 'BPIFB4', 'CTSB', 'CTRC', 'CPA1', 'PPP2R2C', 'UMOD', 'TNFRSF11A', 'OPTN', 'DCSTAMP', 'THBS4', 'SPARCL1', 'PON2', 'PCMT1', 'GJA4', 'ADH1B', 'NUPR1', 'NDUFB8', 'NDUFS3', 'SDHB', 'UQCRC2', 'ATP5MC1', 'NMNAT1', 'NMNAT2', 'NMNAT3', 'TRPM3', 'TRPA1', 'LRAT', 'RPE65', 'RDH10', 'RDH11', 'CRAT', 'ANGPTL2', 'PRDX1', 'GRIK2', 'GSK3B', 'CASP8', 'SRXN1', 'IKBKB', 'SLC1A5', 'SH2B3', 'ATXN2', 'BRAP', 'CCR6', 'PSENEN', 'ATP6AP1', 'ACSL4', 'TMEFF2', 'PIM1', 'CNTFR', 'OLR1', 'DKC1', 'TNS3', 'GHSR', 'ASXL2', 'SORCS2', 'CELSR2', 'NUBP2', 'IGFALS', 'HAGH', 'ETS1', 'GAS6', 'DICER1', 'CXXC1', 'MARF1', 'PDZK1', 'PMP22', 'TNPO2', 'PRDX6', 'HAS3', 'HAS2', 'S100A11', 'CDKN3', 'HOPX', 'SERPINC1', 'ATP4A', 'CRMP1', 'SGO2', 'BTG2', 'CD79B', 'BTG1', 'TBL1XR1', 'BTK', 'TNFRSF1A', 'ICOS', 'DUSP6', 'NLRP1', 'PERP', 'BIRC3', 'SDS', 'COL11A2', 'REV1', 'PFKFB3', 'DIS3L2', 'XRN1', 'TRPC3', 'ORAI1', 'STIM1', 'ATP2A2', 'SNAI1', 'CYP17A1', 'MYOG', 'CCL3', 'EIF4EBP1', 'SRC', 'LGR5', 'PITX2', 'TREM2', 'TMEM106B', 'CR2', 'MOG', 'DCX', 'NES', 'PROX1', 'PLAG1', 'RBFOX3', 'ADAM17', 'MDP1', 'PANK1', 'PANK2', 'HLA-DQA1', 'TCL1A', 'ZAP70', 'MYBL2', 'HDC', 'GCH1', 'ROS1', 'IFIT3', 'PLSCR1', 'PARP9', 'MEST', 'CTCFL', 'RAB11A', 'CRABP2', 'COG5', 'SCN1A', 'GADD45A', 'G6PC1', 'TRPS1', 'F3', 'ICAM3', 'FN3K', 'MYOF', 'ADAM15', 'LEMD3', 'LBR', 'C1QTNF3', 'SLC12A1', 'PDYN', 'RAN', 'BBOX1', 'QDPR', 'PRNP', 'CCND2', 'TNFSF12', 'TNFRSF12A', 'ACTA2', 'RELB', 'RORC', 'DNMT3B', 'HOXB13', 'NOTUM', 'BCL2L11', 'TFRC', 'PRKDC', 'NLRP2', 'ALLC', 'AGO1', 'PM20D1', 'FPR2', 'HSH2D', 'SAA4', 'HDAC3', 'SFTPC', 'SUPV3L1', 'BIN1', 'HSPA5', 'CACNA1C', 'CACNA1D', 'FGB', 'TNK2', 'GIT2', 'GIT1', 'CACYBP', 'PSMB8', 'PPT1', 'PRDX5', 'SYN2', 'KISS1', 'KISS1R', 'NAT2', 'KCNQ4', 'PRAP1', 'TGFB3', 'PGF', 'TMPRSS6', 'NHEJ1', 'CASP9', 'TMPRSS2', 'TMPRSS4', 'KIF11', 'ZNF704', 'COL18A1', 'IDH1', 'S100A1', 'S100A6', 'MT-ND5', 'LILRB1', 'G6PC2', 'S100A9', 'ANKS1B', 'ADAMTS3', 'PPFIA1', 'MMP7', 'FABP2', 'FOSB', 'DMD', 'RNLS', 'FABP4', 'FBH1', 'ELP1', 'TAX1BP1', 'SERPINA6', 'CSH2', 'CD69', 'YTHDF2', 'CCKAR', 'DLST', 'REL', 'MT-ND2', 'PLEKHO1', 'SMURF1', 'SMAD1', 'FOSL1', 'MT1A', 'LRIT1', 'IL6ST', 'ATXN2L', 'HEYL', 'AGRN', 'PPM1A', 'MGST1', 'BIK', 'TLR6', 'AKR7A3', 'FDXR', 'PGAM1', 'SEPTIN2', 'HMGCS2', 'PTGER2', 'FAHD1', 'AGTR2', 'HLA-DRB5', 'RBPMS2', 'GRB2', 'ACMSD', 'DCLRE1C', 'MC1R', 'ID1', 'TAF1', 'IGFBP1', 'ENO2', 'EYS', 'CRX', 'RAX', 'OTX2', 'GNAT1', 'CRYGD', 'ABCC9', 'AQR', 'PLAU', 'CIAO3', 'PSRC1', 'SORT1', 'CILP2', 'PBX4', 'GALNT2', 'TBL2', 'TRIB1', 'ANGPTL3', 'NR1H3', 'SLCO1B1', 'PSMB9', 'PCBP2', 'IFI16', 'MMP12', 'TCF4', 'FN3KRP', 'MIF', 'FZD4', 'MMP13', 'PDGFA', 'CDC42BPB', 'ARHGEF3', 'FUS', 'CEBPB', 'SLC13A3', 'AGPAT2', 'LPIN1', 'MARCHF8', 'ADAMTS5', 'SLC29A2', 'SLC28A1', 'SLC28A2', 'SLC28A3', 'DEFB103B', 'EIF4G1', 'CREB1', 'RBM14', 'RBMS3', 'DDX41', 'NR2C2', 'MYOC', 'ATG16L1', 'SELE', 'EPCAM', 'HTR1A', 'PTGER3', 'ONECUT2', 'AQP5', 'GPC5', 'SLC2A4', 'SOX10', 'WNT5A', 'CCN5', 'ADCYAP1', 'ADCYAP1R1', 'MLKL', 'HPSE', 'TPP1', 'PWWP3A', 'CYP27B1', 'ZNF334', 'AOC1', 'HUWE1', 'CHIA', 'ALAD', 'CD7', 'NFASC', 'ANXA3', 'H1-2', 'RASA3', 'CAPN1', 'CAPN2', 'MAP3K8', 'WFDC2', 'TTN', 'CERS1', 'CA2', 'HAS1', 'AKR1A1', 'EXT1', 'EXT2', 'CCL4', 'CCL17', 'CCL22', 'AKR1B1', 'FAS', 'ARF6', 'EDN3', 'ITPKB', 'RGS4', 'RAB3A', 'SYNGR3', 'IGF2BP2', 'MIB2', 'AGT', 'MAD2L1BP', 'CHRNA4', 'ITPR1', 'DYNC1H1', 'IRF4', 'BNC2', 'NTF3', 'NINJ2', 'SELENBP1', 'KLF2', 'MAPK7', 'PRDM1', 'ASTN2', 'HRK', 'WIF1', 'FBXW8', 'DHFR', 'TYMS', 'EIF5A', 'GAB1', 'NELFCD', 'FMN2', 'MGAT5', 'PSAT1', 'PHGDH', 'NDUFA4L2', 'ATP1A1', 'CA9', 'AQP1', 'SH2D3A', 'VIT', 'CHMP4B', 'PHF1', 'TIPARP', 'FOLH1', 'FPR1', 'IL2RA', 'VCAM1', 'EDNRB', 'NEIL1', 'PTGER4', 'KRT14', 'ST8SIA4', 'DEFB4B', 'SAA1', 'PAX8', 'PRPH2', 'LHCGR', 'FSHR', 'SPI1', 'IRF8', 'AICDA', 'ATF4', 'TCIRG1', 'DISC1', 'TERF2IP', 'TINF2', 'SUB1', 'CYP11A1', 'RAPGEF1', 'CFD', 'ALOX12', 'ALOX15', 'MARCO', 'RAC1', 'SCN8A', 'CYB5A', 'UBE2I', 'TPR', 'RCC1', 'QPCT', 'ADRB1', 'CNR2', 'ESR2', 'COX8A', 'NR4A2', 'SERPINH1', 'RASAL1', 'KRT18', 'ATL1', 'RANBP1', 'BLVRA', 'RAB8A', 'PYY', 'ATP6V1E1', 'GNG3', 'NDUFV2', 'GOT1', 'NAV2', 'NRXN3', 'SMN1', 'VASH1', 'SARM1', 'P2RX4', 'UAP1L1', 'UAP1', 'OGT', 'ALDH4A1', 'MT1X', 'GHRHR', 'COL2A1', 'GATA1', 'ITGA6', 'RBFOX1', 'PDCD1LG2', 'SGPP2', 'DAPK1', 'ANOS1', 'KCNS3', 'RSAD2', 'MKNK1', 'CD2', 'ASGR1', 'WARS1', 'KRT8', 'FOXF1', 'SRRM4', 'TWIST1', 'AXIN2', 'SLC7A8', 'SLC3A2', 'TBP', 'ATXN7', 'IL1R1', 'IL1R2', 'TSG101', 'DEFB1', 'COL5A1', 'RREB1', 'PDE9A', 'DUSP4', 'GREM2', 'CACNA1A', 'TKT', 'ALOX5', 'NRXN1', 'FBXO33', 'SIK3', 'TAL1', 'WWOX', 'MUC5B', 'PARN', 'RTEL1', 'MOK', 'TGFBR1', 'ACVRL1', 'APLNR', 'APLN', 'SLC17A8', 'CNTF', 'GPR55', 'KRT20', 'CD28', 'PMEL', 'CRTC1', 'RPTOR', 'PAX6', 'HNRNPA1', 'GTPBP1', 'DROSHA', 'TNRC6B', 'SDC1', 'UBE2C', 'REXO1', 'TP53INP1', 'RACK1', 'ANKH', 'ENPP1', 'ABCA4', 'IBA57', 'MAP4K3', 'IQGAP1', 'MAP4K1', 'CDCA4', 'CKAP2', 'HAUS4', 'IMMT', 'MTHFD2', 'NEK2', 'NIPA2', 'ELOA', 'DHCR24', 'MAT1A', 'TRAF1', 'BAP1', 'USP16', 'MYSM1', 'DDX58', 'CGAS', 'UNC5B', 'LIN28A', 'SNAI2', 'VCAN', 'CORIN', 'PTCH1', 'TBC1D16', 'WDFY3', 'ARFGEF2', 'DAO', 'GRM1', 'P4HA2', 'SEPTIN9', 'NDRG4', 'BMP3', 'SDC2', 'SFRP2', 'NTRK3', 'CD3E', 'LCAT', 'MARCKSL1', 'MR1', 'RET', 'LOXL2', 'LOXL4', 'IDH2', 'ATG10', 'LIG4', 'ABCC8', 'LXN', 'CIB2', 'PEA15', 'FGD1', 'PLCB1', 'SEMA4G', 'UPF3A', 'CSTB', 'CD99', 'ETV3', 'FJX1', 'TMEM37', 'RPP30', 'ZFHX3', 'CD1A', 'PC', 'TGM2', 'TRADD', 'PEPD', 'RB1', 'BTRC', 'RNF170', 'GHRL', 'GPNMB', 'LTF', 'KLRC1', 'FGF1', 'STING1', 'C5AR1', 'C3AR1', 'SCPEP1', 'NRN1', 'CPLX1', 'SH3GL1', 'GGCX', 'IRF3', 'PNPLA3', 'APOC3', 'TNFRSF18', 'CETN3', 'IKZF3', 'RLBP1', 'RAC3', 'UBE2D3', 'CTSL', 'DGCR8', 'NMUR2', 'PMCH', 'FFAR1', 'MANF', 'HERPUD1', 'SLC4A3', 'GPHA2', 'ASAH1', 'GBA2', 'GRIN1', 'GRIA2', 'BID', 'IL37', 'IL23R', 'KLRB1', 'BCO1', 'ATG9B', 'WIPI1', 'PIF1', 'CLK1', 'C16orf82', 'MYOCD', 'GATA4', 'KRTAP8-1', 'ESCO1', 'TWSG1', 'SLC20A2', 'XPR1', 'SLC20A1', 'TRIM63', 'ACKR3', 'LGALS3', 'MSR1', 'SCARB1', 'SMTN', 'MXD1', 'IKZF1', 'HIC1', 'PPID', 'DYNLT3', 'ALX4', 'PRDX2', 'HNRNPU', 'RPS3', 'RALY', 'RPS9', 'DDX21', 'HNRNPM', 'RBM7', 'MTREX', 'DIS3', 'APAF1', 'UCMA', 'TNFSF13', 'TNFRSF13B', 'TNFRSF17', 'ENG', 'CCL18', 'NPHP1', 'CEP290', 'HOXA3', 'FLNA', 'GDF10', 'KCND2', 'DIAPH2', 'EDEM1', 'HYAL1', 'HYAL2', 'HYAL3', 'TSC2', 'PPP2R5A', 'MAGT1', 'BIRC2', 'NAIP', 'SORD', 'RFC3', 'ITGA4', 'ENHO', 'S100A10', 'RASSF7', 'KRTAP5-6', 'TSPAN32', 'CSPG4', 'GPR17', 'GRIN2B', 'MAP1LC3B', 'GABARAP', 'ATOH1', 'TREX1', 'NPY4R', 'BMP4', 'NONO', 'ASF1A', 'DPP10', 'NPSR1', 'SHANK3', 'BACH1', 'KLHL35', 'ALAS1', 'ALAS2', 'SLCO1A2', 'RYR2', 'TNFSF15', 'CNN2', 'SERPINB9', 'PDE6B', 'CYSLTR1', 'RAB27B', 'TNFAIP6', 'CCL8', 'MST1', 'STK3', 'GGTLC3', 'SLC25A37', 'FXN', 'PABPN1', 'IQSEC1', 'ADGRE1', 'ERN1', 'ATF6', 'ACACA', 'WNT3', 'SOS1', 'ELOVL2', 'PENK', 'NTS', 'ADCY6', 'ITGB3', 'BNIP3L', 'SIGIRR', 'TSLP', 'CPLX2', 'ABCC6', 'ATP5F1A', 'ITGAE', 'FANCB', 'CREB5', 'FCMR', 'TGM1', 'SPINK1', 'PLG', 'GLRA1', 'ITIH5', 'MTCH2', 'HIF3A', 'RAB37', 'TICAM1', 'ATG13', 'CCDC62', 'GAK', 'NMD3', 'PROS1', 'PROCR', 'GATA3', 'MSN', 'LYVE1', 'NCR2', 'NUAK1', 'ATP6AP2', 'BRD4', 'HMGN1', 'HMGN2', 'UCHL1', 'CIAO2B', 'TCF20', 'SLC38A2', 'SLC7A5', 'IL31', 'ELF3', 'POLRMT', 'MRPL12', 'MRPL10', 'SKP1', 'AGFG1', 'PTPRC', 'CR1', 'DNER', 'TRPV4', 'AFG3L2', 'MAT2A', 'SYNJ1', 'SYNJ2', 'MT-ND3', 'MT-ND4L', 'MT-ND4', 'AP2M1', 'MPG', 'BMP5', 'TGM3', 'GRP', 'PECAM1', 'FUT1', 'SLC2A1', 'MLANA', 'ANXA8', 'ZEB2', 'MTERF1', 'PRKCD', 'TNK1', 'KRT10', 'ABCD1', 'ALOX5AP', 'SPRY1', 'TYROBP', 'CA3', 'MUC7', 'GPI', 'PRTN3', 'COX5B', 'ATP5IF1', 'TPI1', 'AGRP', 'C4B', 'MARVELD2', 'CCT8', 'CSMD2', 'CRYBB1', 'CRYBB2', 'PBRM1', 'CCL23', 'MAFA', 'OLFM4', 'THRA', 'THRB', 'ORC1', 'ORC4', 'ORC6', 'CDT1', 'CDC6', 'GPX3', 'NDUFA2', 'NDUFB6', 'HMGCR', 'CRHR1', 'ITPR2', 'ACO2', 'TCN2', 'SENP3', 'MLNR', 'PTPN1', 'PTPRU', 'FCGR2A', 'SPEN', 'RBPJ', 'VKORC1', 'MSRA', 'NDUFA3', 'NDUFA8', 'FANCM', 'FOXO3B', 'VEGFD', 'PIGF', 'CAPN10', 'MAML3', 'MMP3', 'CTSV', 'PMAIP1', 'ARG2', 'HSP90AB1', 'DRD3', 'ETFB', 'ETFDH', 'EMSY', 'CYP26A1', 'IL22', 'CAPRIN2', 'CELF1', 'RBM24', 'TDRD7', 'ACTN2', 'DNASE2B', 'LONP1', 'PDE6A', 'PDE6G', 'CNGA1', 'CNGB1', 'OPN1SW', 'OPN1LW', 'PDE6C', 'PDE6H', 'GRK7', 'FBL', 'MS4A4E', 'VMP1', 'HAVCR2', 'TRPM8', 'ASIC1', 'ASIC3', 'RS1', 'PRPH', 'SYN1', 'LBP', 'PSCA', 'ITGA1', 'ALCAM', 'FAN1', 'DLX5', 'SULF1', 'SULF2', 'OLIG1', 'OLIG2', 'UNG', 'SCGB1A1', 'CPLANE1', 'FGF2', 'IBSP', 'NOL12', 'HSD11B1', 'SERINC2', 'CHST12', 'TOMM20', 'ACVR2A', 'FSTL3', 'CPE', 'ELAC2', 'KDM4C', 'SLC45A2', 'DEF8', 'HERC2', 'MMP24', 'CYP21A2', 'MST1R', 'LHX8', 'LILRB2', 'KDM6B', 'PPM1D', 'BDKRB1', 'BDKRB2', 'TIE1', 'DMPK', 'IVL', 'PIK3C3', 'MYPN', 'CYB5R3', 'PDGFB', 'TRIM59', 'GPR31', 'SERPINA4', 'RNASEH2C', 'IFNL1', 'HSPB8', 'ZYX', 'WNT10B', 'LRRC8A', 'TGFBI', 'DHX36', 'AKT3', 'GABRR3', 'TBC1D4', 'RAB10', 'NR4A3', 'NR2F2', 'RALGAPA2', 'PDE4D', 'TNFRSF25', 'U2AF1', 'CD209', 'LAMP3', 'USF3', 'TCF12', 'WNT16', 'SPRTN', 'IL1F10', 'PTPN5', 'CNP', 'TPSD1', 'TIMP1', 'TIMP4', 'RBM10', 'TLR5', 'NCF1', 'FLT4', 'FLT1', 'AKAP11', 'SMG6', 'UBTF', 'MAPKAPK3', 'PLOD1', 'LIPC', 'TRAF3', 'DCAF17', 'CD27', 'TIGIT', 'KLRG1', 'KCNA3', 'RALA', 'TSTD1', 'IRAK3', 'SELENOS', 'DNAJB9', 'TIMM21', 'ARF4', 'RINT1', 'NXT1', 'CADPS2', 'COG6', 'GLRX5', 'OPRD1', 'CD207', 'NUDT1', 'LGALS4', 'HMGB2', 'LAMP5', 'CD68', 'IL33', 'DMP1', 'MYOZ2', 'MYOZ3', 'FOXD3', 'UTF1', 'HLA-B', 'COL5A3', 'CDK5RAP1', 'CALM1', 'TNFRSF10A', 'COL10A1', 'GDF2', 'NEFM', 'XRCC1', 'NDUFS1', 'RIOK2', 'KLF1', 'DOC2A', 'SNX32', 'STX4', 'STX6', 'TIMP2', 'PDX1', 'AOC3', 'EDA', 'NIPBL', 'SMC1A', 'S100A4', 'NRP1', 'STUB1', 'CAMK2B', 'HSP90B1', 'CTNND1', 'MAPKAP1', 'FMOD', 'GLUD1', 'OSBPL3', 'GJB3', 'RXFP1', 'DNMT3L', 'VGF', 'NFKBIZ', 'SDHC', 'MT-ND6', 'CENPU', 'NSMAF', 'PTPN13', 'ABCF1', 'INPPL1', 'BMPR2', 'VNN1', 'UGT2B15', 'SLC25A27', 'NSD2', 'AKAP10', 'USF1', 'USF2', 'GRHL2', 'JMJD1C', 'BATF3', 'SATB2', 'FOXG1', 'ADH5', 'SIAH1', 'AKAP6', 'MEF2C', 'AMIGO1', 'TMEM119', 'OGN', 'BRINP3', 'SNRPN', 'EXOSC2', 'EXOSC3', 'EXOSC8', 'MPP4', 'USP6', 'CDC16', 'NUP133', 'MFAP4', 'NECTIN1', 'SLC38A1', 'PEAR1', 'ADD1', 'STARD6', 'KIF6', 'RHEB', 'CXCL11', 'NDUFA4', 'NDUFA9', 'LAMTOR5', 'TRPV5', 'UVRAG', 'CDKN2AIP', 'XRCC3', 'CD2AP', 'PRKAG2', 'SESN1', 'EIF3E', 'EIF3A', 'COPS8', 'TCF7', 'HRC', 'ARC', 'F2RL1', 'KLK8', 'GPIHBP1', 'LDLRAP1', 'MYH9', 'RDX', 'SELENOH', 'SELENOV', 'SELENOT', 'CD40', 'ADH1A', 'MGST2', 'VASP', 'PRG4', 'CNBP', 'OSM', 'DAG1', 'DTNA', 'SNTA1', 'GLI1', 'SYT1', 'MMP20', 'TTI1', 'ETV7', 'CD1D', 'WASL', 'MOXD1', 'PCOLCE', 'INSL6', 'ACSM3', 'SAG', 'REG1A', 'ANK1', 'COIL', 'CXCR3', 'CRTC2', 'RICTOR', 'RPS6KA1', 'SHMT1', 'ACLY', 'XBP1', 'NUMB', 'FGF20', 'NEIL2', 'CPNE1', 'SDHD', 'MTTP', 'AKAP9', 'KCNE5', 'SEMA3A', 'PRM1', 'PRM2', 'TNP1', 'TNP2', 'CD226', 'CITED1', 'MEOX1', 'EYA1', 'SHISA8', 'POU3F4', 'CIDEC', 'BAG6', 'RSL1D1', 'NOLC1', 'GTPBP4', 'KCNE1', 'YBX1', 'ZCCHC8', 'FUNDC1', 'CNKSR1', 'TFF2', 'KIF7', 'STK36', 'SUFU', 'DZIP1', 'FRZB', 'SFRP4', 'SFRP5', 'DKK2', 'DKK4', 'WNT6', 'EIF3D', 'SRSF5', 'CD34', 'B3GAT1', 'FADD', 'STARD3', 'GDF5', 'SGCA', 'PAXIP1', 'RIF1', 'APEX1', 'ING2', 'ANKMY2', 'PPY', 'MC2R', 'PRKAR1A', 'IFIH1', 'PRKG1', 'FASTKD2', 'TNFAIP3', 'CHUK', 'FGF19', 'RRM1', 'RRM2', 'SH3BP5', 'CALML5', 'SLC25A6', 'NF1', 'CCL7', 'COPG1', 'CSF2RB', 'ENO1', 'UGCG', 'CAMK2A', 'ATRX', 'DAXX', 'IGF2BP1', 'ANKRD26', 'ETV6', 'PLA2G2A', 'SIX2', 'WASF1', 'TRPV2', 'CCDC91', 'TLR8', 'NFATC1', 'AMD1', 'BTLA', 'SMG1', 'RPL26', 'SRSF7', 'PRDM16', 'FEN1', 'HTRA3', 'POR', 'RPA2', 'PRPF19', 'RAD51B', 'GPR173', 'RELN', 'RPS6', 'DSG1', 'DSG3', 'FOXF2', 'SCN2A', 'PIGA', 'STC2', 'HOXB7', 'TIAM1', 'DNM1', 'MAP1B', 'APOA4', 'TOLLIP', 'CDC25C', 'TRPM6', 'TRPM7', 'MSX1', 'C2', 'LRP1B', 'KCNIP3', 'MSLN', 'HSPA2', 'CNKSR3', 'ORMDL3', 'CRADD', 'MAD2L2', 'REV3L', 'IDH3B', 'DUT', 'FA2H', 'CERS3', 'HLA-G', 'RPE', 'CFL1', 'CORO1A', 'P2RY12', 'PTGER1', 'KIF1A', 'EPHA7', 'SNCB', 'PLD2', 'SPOP', 'HES1', 'TLE1', 'SLC18A3', 'SS18L1', 'H2AC8', 'GRK2', 'RHCG', 'PRR4', 'SLC8A1', 'KDM4B', 'NAA40', 'KNDC1', 'ZNF410', 'TBPL1', 'PAX2', 'CPT1B', 'SELPLG', 'NME8', 'NFAT5', 'DSG2', 'NPTXR', 'CENPF', 'SRSF6', 'EFCAB5', 'INHBE', 'OAZ1', 'GDF6', 'PGM1', 'PGM3', 'CNDP2', 'DDIT3', 'ANXA2', 'SYT9', 'NEB', 'MPV17', 'STIP1', 'MAD1L1', 'HACE1', 'PGAM5', 'CPT1A', 'LIG3', 'KLK6', 'SELENOP', 'FBXO21', 'SOCS3', 'IL27', 'NKX3-1', 'PRRX1', 'CAV2', 'NFATC2', 'SERF1A', 'SERF2', 'CTRL', 'CD302', 'CCAR2', 'CCND3', 'PIAS2', 'STAT2', 'RIN3', 'MECP2', 'LRP8', 'VLDLR', 'DAB1', 'SEPTIN7', 'MAGEA4', 'MDM4', 'PPP2R2B', 'ISX', 'ASIC2', 'DCTN2', 'DCTN3', 'BSCL2', 'CTTN', 'STK24', 'SEPHS1', 'STK39', 'MIS12', 'SBDS', 'SLC19A1', 'PRKCH', 'SH2B1', 'ADIPOR2', 'SHROOM3', 'BCL11A', 'THAP1', 'KLRC2', 'KIR3DL1', 'KIR3DL2', 'RNPEP', 'FABP5', 'SLC30A8', 'BAG2', 'BAG1', 'GPR158', 'DLK1', 'FANCC', 'HMMR', 'NFYA', 'KAT2A', 'VTA1', 'NMBR', 'FOXP2', 'HLA-DQB2', 'H6PD', 'HADH', 'ST6GAL1', 'APCS', 'GYS1', 'PDK4', 'PLCL1', 'TMPRSS5', 'LDLRAD1', 'TGFB2', 'STAT4', 'AGO2', 'TDO2', 'TAGLN', 'IL3RA', 'CLEC12A', 'TRPV6', 'CLDN2', 'SOSTDC1', 'COX4I1', 'RFC1', 'KCNQ1', 'CD177', 'RAB7A', 'ITGB1', 'GPR139', 'DACH1', 'ANPEP', 'FGF4', 'ZMYM2', 'PPHLN1', 'BAIAP2L1', 'TACC3', 'FGFR4', 'CSF1R', 'PKP2', 'MLN', 'KDM1A', 'IL2RG', 'GNAS', 'DCLK1', 'CEP104', 'PCDH20', 'HES5', 'MBL2', 'HPCA', 'UBB', 'PYGB', 'PLAA', 'PCDH8', 'CPT2', 'ACADVL', 'TRIM38', 'CASZ1', 'PI4K2A', 'TSHB', 'DLX2', 'TTI2', 'JAG1', 'ARHGAP1', 'SHC3', 'UVSSA', 'NAT10', 'C1QTNF5', 'PDP1', 'MBD4', 'ALDOA', 'PGK1', 'HTR1B', 'SERPINA7', 'FKBP5', 'SYT4', 'VAV3', 'NEBL', 'DIO3', 'ASPN', 'TSC1', 'METRNL', 'SETD7', 'FGG', 'MCF2', 'PKM', 'CAST', 'FERMT1', 'KCNE2', 'SLC7A11', 'SLC16A1', 'SCG2', 'SERPINA12', 'PTBP1', 'NECTIN2', 'MRTFA', 'MRTFB', 'CFHR1', 'VIPR2', 'ABTB1', 'GRB10', 'RNF123', 'GEMIN4', 'HSD17B3', 'SULT1A1', 'PLCD1', 'PIK3R3', 'IMPA2', 'PI4KB', 'PIK3CB', 'INPP5A', 'CLDN3', 'DUSP1', 'TXN2', 'DNAAF4', 'CNTNAP2', 'DIP2A', 'BCL2A1', 'PDCD6IP', 'EPHB2', 'EIF4A2', 'CD33', 'NR0B2', 'FGF10', 'NOG', 'CNDP1', 'TMEM158', 'COL7A1', 'BCL2L13', 'MMRN1', 'NBAS', 'UGDH', 'MYL9', 'GAD2', 'ADAT2', 'GYPA', 'AAK1', 'LRP6', 'ADCY5', 'ALDOC', 'TRAP1', 'CYP2C8', 'CYP2C18', 'C1QBP', 'RALBP1', 'NR4A1', 'PTGIS', 'WNT7A', 'WNT9A', 'LTV1', 'ZNF20', 'PPP1CB', 'PSG5', 'MCF2L', 'GPA33', 'BMP7', 'ACADM', 'SRY', 'SOX3', 'F11R', 'MAT2B', 'SLC25A32', 'FTH1', 'ELOVL4', 'SORCS1', 'SORCS3', 'H1-4', 'MUC2', 'WEE1', 'IL10RB', 'PDE7A', 'SPOCK3', 'CDH4', 'SLC22A12', 'SMC2', 'SMC4', 'ACP2', 'SLC17A4', 'PIK3CG', 'SLC17A3', 'ADAM19', 'HTR4', 'CLEC3B', 'SLC13A5', 'SORBS3', 'FRK', 'PLCG1', 'SERPINF2', 'BMPR1A', 'SERPING1', 'PDXP', 'BASP1', 'NCDN', 'MFSD2A', 'OTX1', 'SMPD1', 'SCARB2', 'P3H1', 'LIMA1', 'MAGOHB', 'AIRE', 'YOD1', 'UGT8', 'FNDC3B', 'SLIT2', 'BMP6', 'CDC26', 'CCDC181', 'GABRE', 'CSRNP1', 'COX10', 'COX15', 'BBS9', 'HK3', 'BRSK1', 'CSRP1', 'AGBL4', 'IREB2', 'ACO1', 'ASCL1', 'NEUROG2', 'ABCE1', 'NPC1L1', 'SAR1B', 'ADAM12', 'SOX6', 'PRKCZ', 'GNA11', 'COL4A1', 'PLEKHA2', 'PNPLA7', 'MGST3', 'TSNAX', 'RAP1A', 'EIF3F', 'CBLC', 'PON3', 'SELENON', 'PEBP1', 'TCF7L2', 'CAMP', 'ALDH18A1', 'SLC22A5', 'APBB2', 'MKI67', 'IFI6', 'MRPS5', 'LGR6', 'ANGPT1', 'ANGPT2', 'CRYAA', 'SIGLEC11', 'TTF1', 'IRF2', 'NCOR2', 'HDGFL1', 'GAB3', 'PAX3', 'APP', 'S100A3', 'TACR3', 'LGALS1', 'DSTN', 'NME1', 'HNF1A', 'ZMAT3', 'MAGEA3', 'CEACAM1', 'PABPC1', 'SNCG', 'ZDHHC1', 'ZDHHC2', 'KCNA4', 'KCNC4', 'AQP9', 'GLA', 'PNPT1', 'CCNA2', 'CSNK2A2', 'CRY2', 'CRY1', 'KCNH2', 'GYG1', 'GBE1', 'RBCK1', 'PFKM', 'EPM2A', 'NHLRC1', 'PRDM8', 'ATF2', 'FBXW7', 'RBBP4', 'CSNK2A1', 'SUN1', 'KCTD12', 'KIF5B', 'SPTAN1', 'HSPBP1', 'HSD17B11', 'ADAMTSL3', 'CYP1B1', 'ABCB5', 'C16orf96', 'ANK3', 'SIRPA', 'CYP2S1', 'PINX1', 'LEF1', 'RBL1', 'IL32', 'PTGS1', 'AOX1', 'TPM4', 'SUGP1', 'TECR', 'SYCP2L', 'TDRD3', 'FSHB', 'NRG1', 'PIEZO1', 'MID1', 'POU2F2', 'MCM9', 'TRIT1', 'FETUB', 'ITIH1', 'ITIH2', 'ITIH3', 'ITIH4', 'DPH7', 'GALR2', 'LDB3', 'TFCP2', 'TMBIM6', 'HTR2B', 'CLPP', 'B4GALT1', 'IL27RA', 'TMPO', 'MMP8', 'PPP4R3C', 'SMAD5', 'MMP10', 'WDR77', 'GCLM', 'PLA2G6', 'MRPS12', 'PLA2G4A', 'A1BG', 'BARX1', 'GTF2H4', 'GTF2H2', 'CCNH', 'MNAT1', 'NFIB', 'ADNP', 'MAPRE1', 'WDR45', 'ITGA7', 'CXCL6', 'WNT4', 'CASTOR1', 'SLC16A3', 'PLS1', 'MYO5C', 'RMI2', 'CASP6', 'HNRNPD', 'PHF11', 'E2F2', 'TEAD2', 'NF2', 'PHB1', 'MCM10', 'HNF1B', 'PKHD1', 'IFT88', 'CYS1', 'MBNL1', 'RAB22A', 'MLXIP', 'TRIM28', 'HRG', 'CD36', 'CEBPD', 'TPT1', 'PGM2', 'CCR4', 'MRC2', 'MYL2', 'CD70', 'VHLL', 'PTPN7', 'CKMT2', 'FBP1', 'PTPRN', 'EPC1', 'SERPINB5', 'HAVCR1', 'SPON1', 'CALML3', 'CSNK1G2', 'MAP2K4', 'DNA2', 'C1GALT1', 'TDG', 'DCC', 'CADM1', 'GJA5', 'GJC1', 'GC', 'HEXA', 'HEXB', 'COL8A2', 'RPL29', 'FOXQ1', 'TNFRSF8', 'FUT4', 'ALPI', 'SFTPD', 'UBL4A', 'SMARCA5', 'UQCRC1', 'UQCRFS1', 'MRPL15', 'PSIP1', 'TCOF1', 'DDB1', 'DDB2', 'CUL4A', 'CSF2RA', 'MARS1', 'FARSB', 'MS4A4A', 'CFLAR', 'TBPL2', 'DST', 'STAT6', 'DCK', 'GSTO2', 'SAMHD1', 'TAS1R2', 'SCNN1B', 'TFG', 'MYF5', 'MYF6', 'ZKSCAN3', 'KRT15', 'AREG', 'EIF5', 'F5', 'STC1', 'NEUROG3', 'GFPT1', 'ULK4', 'SDCCAG8', 'SCAMP5', 'RPP25', 'VPS37B', 'PPCDC', 'NOS1AP', 'ENTPD8', 'C1R', 'GFUS', 'CIAO1', 'PLXNA4', 'SLC9A1', 'TNRC6C', 'STAMBP', 'KCTD2', 'CHD1', 'PIWIL1', 'BCL10', 'EGR2', 'MVK', 'FABP1', 'CAPNS1', 'SYS1', 'SLC25A24', 'IVNS1ABP', 'ERV3-1', 'GSDME', 'SOAT1', 'HSFX1', 'TOE1', 'ILDR1', 'LIG1', 'BMP15', 'SUCNR1', 'GPR3', 'GRHL1', 'SLC7A1', 'RPA3', 'SPOCK2', 'HCAR1', 'ALKBH5', 'KDM5C', 'KDM6A', 'ADAM8', 'TWNK', 'CDK9', 'COQ7', 'IL2RB', 'CTSE', 'IL36G', 'PPAN', 'MGLL', 'FZD5', 'CBLIF', 'PPA1', 'SMPD3', 'EIF4H', 'SMO', 'LMNB2', 'SSB', 'NFE2L1', 'TRAF2', 'ITPR3', 'CACNA2D1', 'CAMK2N1', 'PEX19', 'BHLHE40', 'FBN1', 'LIMS1', 'SMAD6', 'ZEB1', 'PPARGC1B', 'RGR', 'AKR1C4', 'SNTG1', 'NKX3-2', 'FAR2', 'CALCR', 'CERS4', 'ARNT', 'EGLN3', 'EGLN2', 'EGLN1', 'HTRA2', 'PTH1R', 'GRM3', 'TMEM131', 'TRAPPC8', 'RTN3', 'MARCHF5', 'GRK3', 'GRK6', 'FABP7', 'AFF1', 'BCR', 'XRCC2', 'SMOX', 'FBXO32', 'SRD5A1', 'HTR1D', 'APPL1', 'FAM13A', 'SELENOW', 'BRINP1', 'ACD', 'MED1', 'GJB1', 'DDC', 'FH', 'GJB2', 'AKR1B10', 'ZNF608', 'GRAMD2B', 'WFS1', 'NKX2-1', 'SESN2', 'S1PR2', 'SSTR3', 'CDK8', 'NGB', 'RPL15', 'PCBP3', 'HNRNPA3', 'TRG', 'TRD', 'RAD54L', 'ARHGEF5', 'MAS1L', 'DHODH', 'TOR1A', 'TFR2', 'TCN1', 'CAPZB', 'UBE2O', 'PRDM2', 'TXK', 'MFAP2', 'SMN2', 'INO80D', 'INO80', 'GNL3', 'ACVR1B', 'INHBC', 'NR1D1', 'TSHR', 'TBX3', 'ABCC4', 'ABCC2', 'TRIM32', 'SOCS1', 'CBLB', 'FBXO40', 'TRIM72', 'SH2D1A', 'CMC1', 'ATOX1', 'PADI2', 'PSD2', 'A2ML1', 'NOVA1', 'ADNP2', 'OGA', 'RNF6', 'NIBAN2', 'THY1', 'SPINK5', 'DOHH', 'IGLON5', 'DPP6', 'LRG1', 'UBE3A', 'PLAGL1', 'SGCE', 'L3MBTL1', 'MSH4', 'KCNA6', 'ABAT', 'NDUFAF2', 'HSPG2', 'ADAM22', 'BCL2L14', 'RAB24', 'COLQ', 'PREP', 'CYP2B6', 'NBPF3', 'ANKRD2', 'LCK', 'LAT', 'PRKD1', 'PLD3', 'LAMP2', 'TIA1', 'SH3BP4', 'KLF15', 'IGLL5', 'NDNF', 'TRB', 'ODF1', 'NCSTN', 'PPP1R1B', 'SUSD1', 'OTUD7A', 'LATS1', 'MET', 'ECSIT', 'UNC13B', 'SKAP2', 'PPP2R5C', 'EIF2S3', 'DNAJA3', 'CLPB', 'ATP6V0C', 'ATG4D', 'PDLIM5', 'MACROH2A1', 'FCGR3A', 'CD47', 'BRD7', 'STXBP5L', 'GADD45B', 'MPST', 'ADAMTS14', 'KDM5B', 'STXBP2', 'IRF5', 'SH3PXD2A', 'KLHL24', 'POLR2F', 'LTA', 'TMEM107', 'STK17B', 'SESN3', 'FILIP1', 'SENP6', 'KLHL42', 'CHST11', 'TFAP4', 'SIX5', 'CHST6', 'SNAP91', 'KLF6', 'DUSP2', 'RBM34', 'NELFA', 'KMT5C', 'KAT8', 'S100A13', 'MACROH2A2', 'AIFM2', 'COL13A1', 'IRAK1', 'RBM6', 'CHRNA5', 'DUSP5', 'DOCK8', 'FANCA', 'C4BPA', 'NTNG1', 'CNOT3', 'ACOD1', 'HPGDS', 'UQCC2', 'SLC12A2', 'DYNLL1', 'ILF3', 'AVPR2', 'NMRK2', 'NMRK1', 'TIMM8A', 'DNAJC19', 'PAH', 'PLXNB1', 'KDM4A', 'GPR78', 'FCRL5', 'PAPOLA', 'GALT', 'HAPLN1', 'CRHBP', 'CRHR2', 'NDUFA1', 'NDUFB7', 'NDUFS2', 'SCGB3A1', 'LDLRAD4', 'AK3', 'DUSP3', 'MACF1', 'MICA', 'PDIA6', 'CISH', 'PROM2', 'SBSN', 'SLC39A14', 'AGTRAP', 'CAVIN1', 'RAB40B', 'ZNF292', 'NNMT', 'KCNA5', 'NUP155', 'GRIN2A', 'KCND3', 'IL17D', 'MICU2', 'LRCH1', 'PLEKHA1', 'KRT17', 'PGK2', 'C1QTNF9', 'PPP1R3C', 'TSPYL5', 'CPB2', 'CDC5L', 'TGS1', 'PDGFRA', 'PPIL1', 'AKT1S1', 'ARSA', 'POLD2', 'CELF2', 'CTNNA3', 'CTNNA1', 'ABCB7', 'TACR1', 'SLC39A2', 'EIF2AK4', 'EIF2AK1', 'DELE1', 'ECE1', 'ECE2', 'PCID2', 'SEM1', 'RNASEH1', 'SP8', 'PLAAT4', 'MCHR1', 'MPL', 'TCF21', 'CARS1', 'MBTD1', 'SUGT1', 'ITGB4', 'NRDC', 'NDUFA6', 'CLEC4C', 'CXCL16', 'NCK1', 'PCK2', 'SLC19A2', 'PDE4B', 'WDR48', 'CLDN5', 'OPN5', 'SOX1', 'EID3', 'PARP3', 'TOP1', 'BACE2', 'CHRFAM7A', 'DOP1B', 'HLA-DRA', 'SLC26A7', 'PLA2G1B', 'NKX6-1', 'HIRA', 'UBN1', 'UBN2', 'VSIR', 'PATE1', 'ZBTB21', 'PPIB', 'S100A7', 'TRIM16', 'UNC5C', 'ENC1', 'CAMSAP3', 'WNT2', 'RPS6KA3', 'ITGA2', 'ITGA5', 'CAPN3', 'MCOLN1', 'ITGA3', 'TOP1MT', 'GAS1', 'PDIA3', 'CLN5', 'MZF1', 'INPP5D', 'CCAR1', 'PNKP', 'OSCAR', 'KCNH3', 'RNF19A', 'SLC22A7', 'OR51A7', 'ADORA1', 'HOXA4', 'BCOR', 'BCORL1', 'SFMBT1', 'YWHAQ', 'TET1', 'SDCBP', 'HSPA14', 'LPAR3', 'PTH2R', 'IRAK4', 'CACNB2', 'PLEKHA7', 'MCL1', 'PRPS2', 'RUBCN', 'PPIP5K2', 'NOTCH2', 'ATF1', 'KRT7', 'PIP', 'SMARCA1', 'NUAK2', 'CLTC', 'SPG11', 'WWP1', 'GJB6', 'ATP7A', 'CHRNB2', 'FMC1', 'APOA2', 'APOH', 'GRID1', 'MBOAT2', 'NTNG2', 'CYSLTR2', 'SYNE2', 'CYYR1', 'ABCA10', 'DCLK2', 'NPPB', 'CLCA1', 'MUL1', 'CSNK1A1', 'KCNMB2', 'CAMKK2', 'EXD3', 'BPGM', 'MAP3K11', 'TNKS2', 'TEP1', 'ATN1', 'ITLN1', 'ITSN2', 'FTCD', 'SRFBP1', 'MPLKIP', 'PDXK', 'MIEF2', 'ALDH7A1', 'UGT2B7', 'MACROD2', 'UBL5', 'UFM1', 'MYLK', 'ATP8B1', 'ANGPT4', 'LRFN5', 'USP6NL', 'PURA', 'FCN2', 'SOX4', 'PRKCI', 'ABCA3', 'NDUFAF6', 'MGAT1', 'AURKB', 'HMX1', 'IRX2', 'LAMB3', 'CCR3', 'SGK2', 'SEPTIN3', 'SEPTIN5', 'RHOU', 'ST8SIA2', 'MEOX2', 'FOXC1', 'GPX6', 'HNMT', 'ZFAND2B', 'KRT16', 'MBD2', 'SLC31A1', 'GPX7', 'PALD1', 'MTBP', 'CDC45', 'WRNIP1', 'RAD18', 'HUNK', 'RARG', 'HESX1', 'HCFC1', 'APBA1', 'APBA2', 'GZMA', 'IGSF21', 'RPL13A', 'SDHA', 'YWHAZ', 'PHKA2', 'MATN3', 'PNPLA8', 'SP3', 'TRA', 'KAT5', 'PRELP', 'VRK1', 'DBI', 'CTSS', 'TADA3', 'IFI27', 'LNPEP', 'GPR143', 'OCA2', 'SRGAP2', 'NKAP', 'PRODH', 'USP49', 'DACT1', 'PRMT2', 'PFN3', 'SP6', 'AKT2', 'AK1', 'AURKA', 'RPS18', 'EEF1A1', 'SENP1', 'DLGAP2', 'CHRNA2', 'EPHX2', 'PLPP3', 'CTHRC1', 'ADAMTS13', 'MAP3K19', 'PUF60', 'ACTG2', 'CKS1B', 'PDK3', 'PAGE4', 'KRT1', 'PNMA2', 'SNTG2', 'TRAF3IP2', 'MLXIPL', 'INHBA', 'DCT', 'IFNL4', 'ASPM', 'NLGN1', 'GRM2', 'CYLD', 'PNLIP', 'H1-1', 'KLRF1', 'AHSP', 'BTG4', 'DSCAM', 'CYP2R1', 'DHCR7', 'WLS', 'MAP3K14', 'COL15A1', 'PLCG2', 'KCNJ2', 'FABP3', 'LIPE', 'AGL', 'ADD3', 'HJURP', 'OPRM1', 'TOP2A', 'VPS13A', 'COL27A1', 'CHRDL1', 'LIMK1', 'SSH1', 'ME1', 'ME2', 'NTF4', 'TCF3', 'HMGA1', 'GRB14', 'HTRA4', 'RHD', 'TYRP1', 'SLC24A2', 'ASIP', 'GPR35', 'RASSF9', 'PRDX4', 'GDA', 'ZNF875', 'PTBP3', 'TXNDC5', 'SSBP2', 'COL12A1', 'NCK2', 'TNPO3', 'HSPA13', 'ARRDC3', 'ACSS2', 'BATF', 'STAB1', 'STAB2', 'APC2', 'TJP2', 'ELK1', 'LDHA', 'LAMA4', 'MDH1', 'ALPL', 'KRT4', 'ERG', 'MOBP', 'DBN1', 'TRAF6', 'EBI3', 'MAB21L2', 'FGF16', 'SLC5A3', 'SLC6A6', 'ATG3', 'AHNAK', 'NDUFB5', 'ATP5F1C', 'NDUFB4', 'COX5A', 'UQCRB', 'ATP5MC3', 'ETHE1', 'ISCA1', 'PKIA', 'MMP26', 'TNFSF9', 'DDR2', 'KLF13', 'PPARD', 'HOXC5', 'NCOR1', 'DOC2B', 'KALRN', 'GCAT', 'CUX1', 'DENND1A', 'PRB2', 'TWF1', 'NPTX2', 'FYB1', 'COL9A2', 'CIZ1', 'WNT5B', 'HSPA6', 'BMF', 'MC4R', 'TNFRSF21', 'IL17RC', 'RHBDL3', 'SOX17', 'DNM2', 'MX2', 'CHRNA7', 'UBE2E3', 'OAS2', 'E2F3', 'BEST1', 'FGFBP1', 'ADAMTS10', 'RIC3', 'NLRX1', 'SETX', 'CYP4A11', 'CRISP1', 'AIM2', 'ZFP57', 'PRKCE', 'PLP1', 'PRORP', 'HNRNPA0', 'EPB41L3', 'TAFA4', 'PAX1', 'TAF4B', 'SYCP3', 'YBX2', 'STAG3', 'DAZL', 'STRA8', 'NOBOX', 'ATP13A3', 'ATG4B', 'ATG4C', 'PIM2', 'RAE1', 'ZFHX4', 'OBSCN', 'PTGES', 'CTSW', 'CCL4L2', 'DCXR', 'FUT8', 'MGAT3', 'TENT4B', 'ATXN1', 'IDS', 'NSMCE2', 'CANX', 'STX1A', 'STXBP5', 'STX7', 'STX1B', 'OPA3', 'RNF216', 'OTUD4', 'MAPKAPK2', 'TRIM65', 'FBF1', 'ACOX1', 'MRPL38', 'NBEAL1', 'WDR12', 'VPS13B', 'SLC32A1', 'FAM83H', 'USP18', 'HLX', 'KDM5D', 'NPBWR2', 'S1PR5', 'GALR1', 'TAS2R50', 'VAMP8', 'TSC22D1', 'ARSB', 'SLC27A2', 'JAK3', 'ONECUT3', 'SIX3', 'ATOH8', 'CDKN2C', 'CERK', 'GPR84', 'AMFR', 'MUSK', 'SIGMAR1', 'SPRR2D', 'EPGN', 'PCP2', 'PTPRT', 'TUFM', 'WFIKKN1', 'WFIKKN2', 'ZNF346', 'FANCL', 'NUP153', 'CITED2', 'CDK20', 'ID2', 'CCL20', 'GDF9', 'CYFIP2', 'GABRA3', 'TNFRSF6B', 'HOXA5', 'EIF4E', 'MDC1', 'USP36', 'WDR33', 'PIWIL3', 'NPM2', 'LLGL1', 'BEX2', 'CGREF1', 'EHMT1', 'ZMYND11', 'ARNTL2', 'YWHAG', 'DSC1', 'FAAH', 'TWIST2', 'CTPS1', 'IPMK', 'COL4A3', 'MYOZ1', 'HELLS', 'CLN6', 'INHBB', 'ENAH', 'M6PR', 'SCGB3A2', 'XPO5', 'NCF2', 'NEFH', 'BARD1', 'MAVS', 'PAWR', 'EDN2', 'ARHGDIA', 'KMO', 'KYNU', 'NFYB', 'TAS2R16', 'RAPGEF3', 'HERC3', 'TGFBR3', 'CD52', 'SAT1', 'TRHR', 'GFI1', 'DYNLRB2', 'ZMYND10', 'DNAH5', 'CFAP52', 'ODAD2', 'RNF4', 'FCER2', 'CD44', 'ZC3H11A', 'SNRPE', 'SOX13', 'ETNK2', 'GOLT1A', 'ADAT3', 'PLEKHA6', 'PPP1R15B', 'PIK3C2B', 'TAS1R1', 'SUMO2', 'PTGDR', 'HTR6', 'RNASE1', 'PLVAP', 'MPZL2', 'ANK2', 'ALMS1', 'EBF4', 'KDM2B', 'FCGRT', 'JUP', 'PLA2G3', 'TET3', 'ILK', 'H3C6', 'PHF19', 'PCDH9', 'ICAM5', 'RMI1', 'UBIAD1', 'ZFPM2', 'NEDD1', 'CCN3', 'FKBP1A', 'HSPA12A', 'GIGYF2', 'GSTA1', 'CCN6', 'ARHGEF2', 'PAK4', 'KLK1', 'KLK15', 'KLK9', 'JSRP1', 'CAB39', 'MTMR14', 'SRL', 'MYH1', 'NCOA5', 'TSHZ3', 'DSC2', 'TNFRSF14', 'HDAC10', 'MSRB3', 'COL8A1', 'TFAP2B', 'HOXB5', 'LYN', 'CNN1', 'DPYSL2', 'PSG1', 'KANK4', 'MAF', 'CNMD', 'LARP7', 'APOC2', 'APLP2', 'CLCA4', 'MS4A12', 'GUCA2A', 'GUCA2B', 'LGMN', 'NXNL1', 'GSTM2', 'CCL16', 'CIRBP', 'HADHB', 'FKBP4', 'TP53I3', 'RPL28', 'BCAS1', 'CLDN4', 'POU3F2', 'POU3F3', 'PLXNA2', 'TNS4', 'DYNC1I1', 'HLA-C', 'ACP1', 'TNIP1', 'CMKLR1', 'CCRL2', 'CMKLR2', 'PADI4', 'CDC14A', 'CDC14B', 'SENP2', 'HTR7', 'FXYD1', 'ARL8B', 'ATP6V1A', 'TGOLN2', 'VPS35', 'S100P', 'GZMH', 'BCL11B', 'TRERF1', 'VAMP2', 'PCDH10', 'CFAP74', 'MYO5B', 'RASGRP1', 'SFTPA1', 'SULT2A1', 'HSD3B2', 'SKIL', 'DYSF', 'EPS15', 'UPF1', 'YY2', 'DYRK3', 'HINT1', 'RCE1', 'ICMT', 'CTSZ', 'RNF168', 'AMBRA1', 'CHMP2B', 'RAB5A', 'CYP4F2', 'GCFC2', 'NME4', 'POU2F3', 'CEMIP2', 'PNMT', 'IFFO1', 'ITGB5', 'ITGB6', 'HAT1', 'KCNJ8', 'APTX', 'TDP1', 'PHLDA1', 'AMHR2', 'PTPN6', 'RBM20', 'FMNL3', 'SHANK2', 'HNRNPC', 'FOXE1', 'TTF2', 'FOXR1', 'PAM', 'ADIPOR1', 'PYCARD', 'CTSA', 'RPS6KB2', 'P2RY11', 'TLR10', 'IL17F', 'SLC25A1', 'CIC', 'CCNE2', 'IL18RAP', 'SLC5A1', 'CHMP1B', 'POLG2', 'SLC25A4', 'HOXC12', 'ANXA6', 'SIGLEC10', 'AHCY', 'DNAJB1', 'TIMM13', 'ENPP2', 'LPAR1', 'DAAM2', 'DIAPH3', 'INF2', 'FHOD3', 'TEAD4', 'TALDO1', 'PLIN3', 'PLIN4', 'MYH6', 'TNNT2', 'CUL3', 'LTB4R2', 'LDHB', 'CD180', 'TUBB3', 'APOLD1', 'EPYC', 'FECH', 'TYMP', 'RAP2A', 'SYCP2', 'CRYZ', 'LTBR', 'SLC40A1', 'OTUB1', 'OTUB2', 'FOXN3', 'ATP4B', 'HMGCS1', 'STAU2', 'NDN', 'NAP1L2', 'RBBP5', 'SIN3A', 'SP2', 'ZNF143', 'ARID5B', 'PLA2G4B', 'ALOX15B', 'PDCD4', 'GNE', 'JTB', 'ALDH1A1', 'ALDH3A1', 'KLRD1', 'F10', 'PRKCB', 'REG4', 'RGS10', 'PZP', 'NNT', 'GNRHR', 'KRT6A', 'BCL2L2', 'ZIC1', 'ZBTB7A', 'ABCA13', 'HBG2', 'PDXDC1', 'RANBP17', 'POMP', 'PCOLCE2', 'SLC36A1', 'SLC38A7', 'TECPR2', 'CINP', 'AK2', 'SLC4A4', 'SPTBN1', 'ARRB1', 'AHCYL1', 'DNM3', 'HSD17B4', 'FDFT1', 'KHSRP', 'SFPQ', 'DDX46', 'SNRPF', 'U2AF2', 'IDH3A', 'SLC30A5', 'SLCO1C1', 'GNB5', 'TM4SF20', 'SP4', 'SALL4', 'F11', 'CCL21', 'BCAT1', 'TRIM58', 'COL5A2', 'RPS23', 'RAD23B', 'GABRA1', 'GABRB3', 'ATG2B', 'GSKIP', 'FCGR2C', 'ATF5', 'IL1RL1', 'BPI', 'MYH3', 'STAG1', 'STAG2', 'DEPP1', 'HOXA10', 'STK17A', 'SRSF12', 'PYGM', 'GRSF1', 'TMEM11', 'S100A2', 'S100A5', 'ZNF266', 'PATZ1', 'KLF5', 'RNF11', 'SPART', 'COX7A2', 'AZU1', 'ZNRD2', 'SHMT2', 'GSAP', 'PAAF1', 'SRSF4', 'CES1', 'TRIM29', 'EXOC3L2', 'BLOC1S3', 'MARK4', 'DDAH2', 'FADS3', 'GPC1', 'GYPC', 'SPATA31A1', 'RBM3', 'KLB', 'DGAT2', 'ELOVL6', 'PPP1R15A', 'HYOU1', 'DNAJC3', 'CRELD2', 'NOXO1', 'SLC22A11', 'R3HDM2', 'SLC17A1', 'ISL1', 'DNAJC7', 'CREB3L4', 'NSD1', 'VHL', 'DEPDC5', 'NPRL3', 'NPRL2', 'KLHL22', 'AKR1C2', 'ITGB2', 'RAD23A', 'DCD', 'HSD17B1', 'GLIPR1', 'USP28', 'SLC11A2', 'RPS4X', 'BCL2L10', 'CETN2', 'REEP4', 'GRIN3A', 'CERT1', 'POU4F3', 'H4C12', 'DIXDC1', 'KRT31', 'MYO1G', 'AKAP13', 'ADAMTS2', 'HGFAC', 'TLE3', 'HM13', 'WDR1', 'LMAN1', 'EID1', 'ATP2B4', 'RAB1A', 'TM4SF1', 'SSR3', 'ACER1', 'ACER2', 'ACER3', 'TM2D3', 'RHOB', 'HEPH', 'AGXT', 'LRRK1', 'PDCD10', 'P4HA1', 'GNG2', 'TNPO1', 'PPP1R16B', 'SYNE1', 'SPATA18', 'LTBP3', 'SLC1A6', 'DIO1', 'DIO2', 'CXCL3', 'SMCHD1', 'LRIF1', 'CYP11B1', 'TMEM39A', 'SEC23A', 'ID4', 'ADGRA3', 'LRRTM3', 'TXNRD2', 'BYSL', 'DDX56', 'WDR75', 'KLHL7', 'KBTBD6', 'NAT1', 'PTGES3', 'FCGR3B', 'THADA', 'FOXL2', 'NUDT3', 'HECW2', 'HIP1', 'BIN2', 'LMO4', 'NETO1', 'TBC1D10B', 'RAB35', 'ABL2', 'IFNL2', 'PRKAR2B', 'HBP1', 'GPR22', 'DUS4L', 'CYTL1', 'HLA-DQA2', 'C1QB', 'HLA-F', 'WNT7B', 'WNT8A', 'GPX2', 'IL26', 'CEND1', 'GNAT2', 'CTNNBIP1', 'ELP3', 'LAMC1', 'NID2', 'TPM3', 'MEF2A', 'PITX1', 'GFRA2', 'MAP4K2', 'KRT72', 'KRT25', 'GCNT2', 'CXADR', 'IGSF3', 'NR5A1', 'SLC4A10', 'NRG3', 'ZRSR2', 'UPP1', 'DYRK2', 'ELF4', 'MYBL1', 'FAT1', 'REXO2', 'SGK3', 'CAMK1D', 'CDC123', 'JAZF1', 'TSPAN8', 'DAB2IP', 'ZFAND2A', 'PSMG2', 'PELI1', 'TNNI3', 'AXIN1', 'DCAF1', 'OLA1', 'SMYD3', 'RCOR1', 'HTR2C', 'CRIP3', 'NCS1', 'CACNA1E', 'KATNB1', 'NAP1L1', 'FOXA3', 'USP3', 'LRIG3', 'PRPF31', 'SLC22A2', 'SLC47A1', 'DDX20', 'ELK4', 'TGIF1', 'TNC', 'ACTN4', 'CAPG', 'CXCR6', 'BPHL', 'RPS2', 'TIMM23', 'DTX3L', 'PARP14', 'HABP2', 'DNMBP', 'KRT13', 'PDE11A', 'PRDM13', 'MPRIP', 'BNC1', 'TAF7', 'TAF7L', 'GAPDHS', 'INCENP', 'SLC41A1', 'CDCA7', 'C1orf112', 'CCL1', 'MT1H', 'LAMB1', 'MRFAP1', 'MRGBP', 'TSPAN15', 'MAPRE3', 'USP22', 'RDH5', 'GGTA1', 'DEFA4', 'TIRAP', 'NOVA2', 'CREB3', 'RAPGEF4', 'CADM2', 'RENBP', 'DLX3', 'CST5', 'SLAMF1', 'UBQLNL', 'RUFY3', 'CD1B', 'CD1C', 'RAG2', 'CD3D', 'NUP93', 'KLK11', 'TENM4', 'KLF7', 'TNFRSF13C', 'DDX53', 'MTX2', 'IRGM', 'JADE2', 'PRDM10', 'SECISBP2', 'SEPSECS', 'GPR162', 'PGD', 'TAC4', 'MSMB', 'NELL1', 'CHST4', 'SORBS1', 'ZNF2', 'RPL37A', 'CLCN7', 'MYBPC3', 'ATP5PF', 'HNRNPA2B1', 'FEZ1', 'TUBAL3', 'STK40', 'GALNS', 'HHLA2', 'PSME1', 'PDP2', 'HP1BP3', 'SLC23A1', 'CST4', 'CCR9', 'MADCAM1', 'VAT1', 'SYNPO', 'TREM1', 'ATP2A1', 'RBM38', 'PSMD13', 'CELA1', 'STOML2', 'FCRL1', 'POLD4', 'CLIC3', 'PBX3', 'SAMM50', 'TIMM22', 'IL34', 'ZNF367', 'ATF7', 'LPAR2', 'PADI1', 'MCU', 'BTG3', 'G0S2', 'MAPK10', 'H1-5', 'MEN1', 'CRB1', 'YWHAE', 'NT5E', 'COL11A1', 'UCN3', 'KMT2C', 'SIGLEC14', 'KIF1B', 'COX7C', 'TPCN1', 'CCL19', 'VPS33B', 'N6AMT1', 'TUBB2A', 'BTC', 'TBC1D3C', 'ZRANB1', 'YJU2', 'POLR2I', 'DOK3', 'TBK1', 'RGS20', 'NRCAM', 'EMP3', 'ADAMTS9', 'LIN7A', 'DOCK9', 'CLIC1', 'ARL1', 'MAST3', 'LPCAT4', 'CAMK2D', 'TM6SF2', 'OPN1MW', 'EIF2A', 'EI24', 'MED31', 'RPS27A', 'ARHGAP4', 'DPM1', 'RPL36AL', 'MED6', 'PSMA3', 'SLC29A3', 'TUG1', 'CD5L', 'AKAP4', 'CD24', 'NANP', 'ACOX2', 'ACOX3', 'DSPP', 'CD93', 'LRRN2', 'TEAD1', 'ABLIM3', 'GPR21', 'ZHX3', 'TOP3B', 'TSC22D3', 'USP17L2', 'CD74', 'CASP12', 'EPHA5', 'CARTPT', 'NKG7', 'CKLF', 'LRP4', 'GDPD3', 'MAP2K6', 'LMX1B', 'PGRMC2', 'PGRMC1', 'TAF15', 'MAPK15', 'HPS1', 'NPR1', 'ORAI3', 'EPHB4', 'SIGLEC1', 'RETREG1', 'RETSAT', 'MICAL2', 'CTAG1A', 'MRPS26', 'MRPS17', 'MRPL51', 'MRPL18', 'SLC25A33', 'MTHFD1L', 'RAC2', 'WWC2', 'ACADS', 'GRIK4', 'CD164', 'TUSC2', 'HECW1', 'PKHD1L1', 'LAMA2', 'SEMA6A', 'MORC3', 'TRIM21', 'GRIP1', 'GRID2IP', 'SCN3B', 'GRIA3', 'GRIP2', 'IL25', 'CWC27', 'TULP4', 'HOMER1', 'RAD21', 'SHOX2', 'ALDH1A3', 'GCGR', 'SLC14A1', 'NHLH2', 'MAFB', 'ERRFI1', 'NDRG1', 'GPR19', 'PLD5', 'DEK', 'CD244', 'ADGRA2', 'PRDM5', 'GLI2', 'VAV1', 'FOXJ2', 'ZC3H12D', 'CCL28', 'TACC2', 'RND3', 'CCDC170', 'STK33', 'CNTN1', 'SMOC1', 'MSI1', 'MSI2', 'TNFSF18', 'RGS6', 'TUBA3D', 'GPC3', 'CD55', 'GNAQ', 'CALN1', 'PYROXD2', 'FANCG', 'ADGRF5', 'ABHD5', 'ISLR2', 'EN1', 'SART1', 'MYH7B', 'PORCN', 'RSPO2', 'LGI4', 'TRIB2', 'HOXA6', 'CDKL5', 'MYH8', 'IGFN1', 'NPHS1', 'TMC8', 'ZNF577', 'GLUD2', 'CUL9', 'LTB', 'SPIB', 'SEZ6', 'KCNA2', 'KCNS2', 'KCNS1', 'CDKL1', 'SLC10A2', 'CLPTM1', 'PAK6', 'GLS2', 'EFNA2', 'ACVR1C', 'ZNF7', 'ENOSF1', 'PACSIN3', 'MEAK7', 'EIF5A2', 'ASNS', 'RHOXF1', 'TBX20', 'FCER1A', 'TFF3', 'CGN', 'MARVELD3', 'PNP', 'IL19', 'KCNJ6', 'CTSF', 'CYC1', 'MED13', 'ZBTB7C', 'WWTR1', 'TBCD', 'RNF213', 'DNAH7', 'PHLDA2', 'ELAVL4', 'ALKBH8', 'DPPA3', 'OR10A3', 'CD63', 'ITGAV', 'FOLR2', 'ABCA2', 'SV2B', 'HECTD1', 'RFC4', 'NABP1', 'MMS19', 'KIF15', 'ACKR1', 'SGCG', 'VAPB', 'RMDN3', 'PRMT5', 'MYO1B', 'DGKB', 'GPRC5D', 'XCL1', 'PFKP', 'NWD1', 'TCF19', 'EDARADD', 'GREM1', 'CCT6A', 'NRP2', 'MYLK3', 'GAL', 'CFHR3', 'RAMP3', 'FCRL3', 'FCRLA', 'IGSF6', 'LUZP1', 'PLEKHM1', 'ATP13A2', 'VPS13C', 'DNAJC6', 'MCEMP1', 'UXS1', 'GSDMD', 'ERAP2', 'ZBTB7B', 'YPEL2', 'PLEK', 'BTN3A1', 'CYTIP', 'HIF1AN', 'MATK', 'FBXO7', 'RPS20', 'DR1', 'NCAN', 'BCAN', 'SLC6A9', 'PCYT2', 'CBX5', 'PRG2', 'MAGED2', 'FAP', 'SCN9A', 'UBQLN1', 'NEIL3', 'MNX1', 'PTTG1IP', 'VPS37A', 'GLIS3', 'RGS3', 'RPS19', 'UTS2', 'JMJD6', 'OSMR', 'IFT52', 'RPL3', 'ZPR1', 'MYT1L', 'NEUROD6', 'HEXIM1', 'SPINT1', 'PTPRM', 'NBL1', 'ROR1', 'IL13RA1', 'PCDH7', 'FLVCR1', 'PTPA', 'ZNF483', 'TMEM38B', 'CENPW', 'OLFM2', 'SCO1', 'NXPH2', 'UBA5', 'EIF2D', 'MOB1A', 'MOB4', 'CLCN3', 'SVIP', 'SCNN1A', 'BST2', 'RAB3GAP1', 'EPG5', 'DBR1', 'MMUT', 'VDAC3', 'VDAC2', 'TRAPPC2L', 'NODAL', 'SLC5A5', 'PPP1R13B', 'TPRKB', 'OSGEP', 'WDR73', 'LAGE3', 'TP53RK', 'OSTM1', 'PSMB1', 'CLN8', 'IFNL3', 'FAM20C', 'PPFIA3', 'PPME1', 'MARS2', 'SLC12A5', 'ERLIN1', 'RSF1', 'PHACTR1', 'SPTA1', 'PRDM9', 'SLC22A8', 'TJP3', 'ANO1', 'UBQLN2', 'IL10RA', 'IL36RN', 'PRRC1', 'NSUN5', 'DNAH1', 'ATP10B', 'CHMP1A', 'SLC25A39', 'GIPC1', 'TOMM22', 'KIF21B', 'KIF24', 'HTN3', 'ZFYVE26', 'PALB2', 'KIR2DL1', 'KIR2DS4', 'KIR2DL3', 'HLCS', 'TPCN2', 'SAMD9', 'RLN2', 'MALT1', 'HELB', 'URI1', 'SLC39A7', 'NPAT', 'MFSD8', 'CTNS', 'ACVR1', 'EFEMP2', 'MYOM2', 'ZFP14', 'COA7', 'PCNT', 'GLI3', 'COL4A5', 'COL4A4', 'NFIC', 'PPP1CA', 'CCNT1', 'RAD51D', 'CYFIP1', 'CDCA2', 'NCAPG', 'PBK', 'NCAPH', 'NCAPG2', 'MELK', 'ESCO2', 'NUSAP1', 'GINS1', 'CDH3', 'GINS4', 'GPR27', 'STYX', 'CUL1', 'SPON2', 'PIK3CD', 'NLE1', 'HHEX', 'KIAA1549', 'MTM1', 'AMACR', 'HOXB8', 'PSMD12', 'TOX3', 'SLC22A18', 'SRR', 'VPS28', 'VPS25', 'VPS4A', 'CHMP3', 'MBD5', 'ENDOU', 'DAZAP2', 'FOXA2', 'FOXH1', 'HADHA', 'MASP1', 'LAMA3', 'LAMC2', 'FBXO9', 'EPHA3', 'CD48', 'ATAD3A', 'UGT2B28', 'TPH2', 'UBXN4', 'EPAS1', 'ITPA', 'ADGRL3', 'USP19', 'GDAP2', 'IGHMBP2', 'DMXL2', 'CHCHD10', 'GABPA', 'HJV', 'NAPEPLD', 'ERVFRD-1', 'ERVW-1', 'RNF149', 'ARX', 'MIA', 'NLRP11', 'ELAVL2', 'CENPE', 'SWI5', 'RCBTB1', 'KCNH1', 'F9', 'BPTF', 'UROS', 'CYTH3', 'ADGRE2', 'PRLR', 'TTBK2', 'SPTB', 'NTN4', 'PARP2', 'E2F4', 'TFDP2', 'MYH7', 'HAX1', 'CSF3R', 'CHRNA1', 'ARL6IP1', 'GM2A', 'ARHGEF12', 'WTIP', 'RBL2', 'SPRED2', 'SDHAF2', 'TMEM127', 'GNG11', 'ARNT2', 'ETF1', 'DSTYK', 'DDX6', 'FBXL2', 'PAFAH1B1', 'COL6A2', 'COL6A3', 'GALNT13', 'MTAP', 'NADK2', 'CIITA', 'SLC2A3', 'TIGAR', 'TPH1', 'P4HB', 'RANBP9', 'EIF3C', 'CCBE1', 'MATR3', 'DDX3X', 'MLF1', 'PARL', 'TENT2', 'CPEB1', 'CDCP1', 'SERTAD1', 'SMARCD3', 'SSX2', 'WAS', 'WIPI2', 'TRAF3IP3', 'GNLY', 'GTSF1', 'SYCP1', 'ITK', 'DNAJC5', 'SYT13', 'PKLR', 'FBXO3', 'NR2E1', 'CLDN8', 'CDHR3', 'SPNS2', 'VTCN1', 'SPTBN2', 'ABCC3', 'CTBP1', 'ULK3', 'MYLK2', 'FIGLA', 'ZP2', 'SKI', 'FZD2', 'MYCN', 'TK2', 'GEMIN5', 'ASAP2', 'MLLT1', 'STMN2', 'ETNPPL', 'TADA2A', 'LRBA', 'SPTLC1', 'CD320', 'LCP1', 'IP6K3', 'COPB2', 'KDM5A', 'SOX8', 'C9orf152', 'RAB30', 'NRK', 'MRC1', 'ATP11A', 'POLR3E', 'TUBA1A', 'TUBB2B', 'SCUBE2', 'ZP1', 'OCRL', 'FAM72B', 'AMOT', 'OPRK1', 'DAPK2', 'INTS11', 'AMELY', 'YY1AP1', 'USH2A', 'DUX4', 'TANGO2', 'TBX4', 'LARP4', 'CCL13', 'SLC19A3', 'NDEL1', 'ASH1L', 'CSE1L', 'YARS2', 'MAP1S', 'DEF6', 'RLF', 'SLC52A2', 'SLC52A3', 'HBS1L', 'LARP1B', 'TNNI2', 'TAP2', 'SEC14L2', 'ATP11C', 'LTBP2', 'MUC4', 'LAMB2', 'MELTF', 'LIPA', 'SLC13A1', 'TOX', 'SLCO2A1', 'MACC1', 'KLF8', 'USP44', 'MTMR2', 'SPRR1B', 'ZFX', 'ZFY', 'E4F1', 'P2RY6', 'BOP1', 'MYO1C', 'FOSL2', 'BET1L', 'MAGEA10', 'HUS1', 'CBLL2', 'CSN2', 'BRF1', 'VPS26A', 'VPS29', 'NDUFA13', 'MKS1', 'CYP4V2', 'ARHGAP24', 'LZTR1', 'SMARCB1', 'UBA1', 'ELAVL3', 'PRSS12', 'CASP4', 'PFN1', 'GCDH', 'OXA1L', 'EGFL7', 'CLCN2', 'MS4A1', 'SLC22A17', 'UNC13A', 'KIFAP3', 'MKRN3', 'CIP2A', 'TPPP', 'CCDC6', 'SLC6A5', 'MAGOH', 'PDCD5', 'PDIA2', 'SUMF1', 'DEAF1', 'PPP1R9B', 'SHC4', 'SULT1C4', 'SULT1A2', 'MBTPS2', 'EEF1A2', 'ART3', 'TTYH1', 'CDC73', 'USP25', 'FTSJ1', 'AFF3', 'AFF2', 'GNPAT', 'NANOGP8', 'PEMT', 'ABCB4', 'SLC34A2', 'SMOC2', 'ARID1B', 'TYK2', 'BSND', 'COMMD1', 'RAB4A', 'SLC16A2', 'SERPINB3', 'OR2A4', 'EBF2', 'YARS1', 'RANBP2', 'SEC31A', 'TPM2', 'PNOC', 'SUOX', 'APOBEC3G', 'TK1', 'IGSF11', 'DDN', 'MYH14', 'GJB4', 'CDH23', 'SARS1', 'CDK19', 'ATRIP', 'TRPM1', 'PI3', 'POLN', 'EP400', 'CHD5', 'ATG4A', 'SCN3A', 'HGSNAT', 'PTPRF', 'PROP1', 'PLK5', 'PLK4', 'DFFA', 'AKR7A2', 'ALDH5A1', 'GDAP1', 'FKRP', 'PEX7', 'FAR1', 'PEX5', 'METTL5', 'RPS7', 'UBAP1', 'FAM135B', 'NAA25', 'KTN1', 'DPT', 'COPS2', 'KRT6C', 'ZNF217', 'KCNJ4', 'TDP2', 'LTBP1', 'WWP2', 'IGFBP6', 'DYNLL2', 'MMP11', 'RINL', 'IRX3', 'GAB2', 'USP13', 'NFIL3', 'MTHFD1', 'SLC38A10', 'DUOX1', 'P2RX1', 'IFI30', 'TRAIP', 'PANX1', 'GRAMD1B', 'PIR', 'TMSB10', 'RBP1', 'EIF1', 'TMSB4X', 'FOXN4', 'COL4A2', 'KLF12', 'CAP2', 'NFIA', 'USB1', 'IGFBPL1', 'STAU1', 'TFDP1', 'FXR1', 'HOXA11', 'HOXD9', 'PBX1', 'DLX1', 'E2F7', 'SIK1', 'ENDOV', 'ZPBP', 'ZNF133', 'MAGI1', 'SPATA48', 'BPIFB1', 'RIMBP2', 'FGF14', 'COX18', 'ELOVL5', 'OSTC', 'NKAIN4', 'CAMTA1', 'RPL18', 'RPS15', 'RPS21', 'YTHDF3', 'MAP4', 'CNTNAP4', 'NEURL4', 'COBL', 'SCGB2A1', 'TONSL', 'GPR65', 'GPR4', 'DISP2', 'IL17RA', 'COL16A1', 'EFNA3', 'WRAP73', 'CPEB4', 'ALG3', 'ALG5', 'MGAT4C', 'NCOA4', 'POTEM', 'APOO', 'APOOL', 'GOT2', 'TEFM', 'SCNN1D', 'PITPNM1', 'HCN2', 'FBXL19', 'BTD', 'MYH2', 'CDC37', 'TRRAP', 'PYDC1', 'NPNT', 'CSTA', 'DEGS1', 'MYLIP', 'CNGA3', 'IGF2BP3', 'CHRM1', 'TWF2', 'COL14A1', 'LTBP4', 'FBLN2', 'LUM', 'XYLT1', 'RPGR', 'GNMT', 'BLMH', 'FSIP2', 'DPEP1', 'NUFIP2', 'UBD', 'LAPTM4B', 'RAD54B', 'ALDH3A2', 'RNF24', 'KIF20A', 'PI16', 'ITGA11', 'NFATC3', 'GSDMA', 'ZFP82', 'PIK3IP1', 'ARHGAP27', 'RPP14', 'PCLAF', 'CCNB2', 'RSPO3', 'GP1BB', 'ICAM2', 'KIF5A', 'CLEC4D', 'SMS', 'CD81', 'MUC6', 'GOLPH3', 'PLOD2', 'PAICS', 'MDGA1', 'NAAA', 'CLEC1B', 'PLXNB3', 'ADAM23', 'BEGAIN', 'HCCS', 'S1PR3', 'TAP1', 'MYO6', 'DLL3', 'IZUMO1', 'SPAG6', 'PLCZ1', 'CAPZA3', 'SLAMF7', 'CD37', 'DSCAML1', 'GPR18', 'UHRF2', 'RABEP1', 'SLCO3A1', 'MAN2A1', 'ALYREF', 'SUPT5H', 'GPC6', 'CD83', 'SVEP1', 'NOC3L', 'SPAST', 'MED28', 'IL12A', 'WSB1', 'IL17C', 'GNL2', 'APELA', 'CDK11B', 'OSR1', 'PDGFC', 'NXN', 'LEFTY1', 'HPN', 'SLC25A5', 'POLE3', 'MPHOSPH8', 'POLE4', 'MIR221', 'MIR222', 'MIR21', 'MIR372', 'MIR30B', 'MIR30D', 'MIR31', 'MIR30A', 'MIR654', 'H19', 'PVT1', 'MEG8', 'MIR146A', 'MIR1263', 'MIR215', 'MIR551A', 'MIR296', 'MALAT1', 'MIR17', 'MIR106A', 'PTCSC3', 'MIR335', 'SCARNA6', 'SNORD55', 'SNORA20', 'TEX41', 'MIR155', 'MIR543', 'HCCAT5', 'KCNQ1OT1', 'MIR124-3', 'MIR760', 'MEG3', 'MIR137', 'MIR19B1', 'MIR203A', 'SNORD95', 'MIR885', 'MIR9-3', 'MT-RNR1', 'VTRNA2-1', 'TERC', 'MIR1323', 'MIR125A', 'MIR34A', 'MIR424', 'MIR29B2CHG', 'MIR28', 'MIR204', 'MIRLET7C', 'MIR192', 'MIR10A', 'MIR10B', 'MIR375', 'MIR6895', 'MIR6791', 'MIR518F', 'MIR223', 'MIR664A', 'MIR7704', 'ZNF503-AS1', 'PRDM10-DT', 'PWRN2', 'TRS-AGA2-3', 'SNORD3B-1', 'NEAT1', 'BDNF-AS', 'BACE1-AS', 'CDKN2B-AS1', 'XIST', 'CDR1-AS', 'PCAT1', 'MIR29B1', 'MIR490', 'MIR7-3', 'MIR145', 'PRAL', 'MIR1343', 'MIR107', 'MIR1245A', 'MIR6507', 'MIR568', 'MIR140', 'LINC01587', 'MIR3613', 'JPX', 'MIR18A', 'MIR206', 'MIR34B', 'MIR34C', 'HOTAIR', 'MIR126', 'CD27-AS1', 'MIR224', 'GAS5', 'MIR141', 'MIR143', 'DANCR', 'MIR1301', 'MIR98', 'ERICD', 'MIR570', 'MIR3127', 'MIR95', 'MIR132', 'MIR15A', 'MIR320A', 'MIR1202', 'MIR935', 'MIR217', 'MIR127', 'MIR27A', 'MIR326', 'MIR29A', 'MIR548E', 'MIR216A', 'MIR599', 'MIR150', 'MIR191', 'TLX1NB', 'MIR448', 'MIR5588', 'MIR3658', 'MIR567', 'MIR3908', 'MIR1973', 'MIR185', 'MIR136', 'MIR195', 'MIR205', 'MIR139', 'MIR452', 'MIR186', 'MIR342', 'MIR449A', 'LINC00458', 'MIR6776', 'MIR3620', 'MIR4747', 'MIR212', 'MIR130A', 'MIR675', 'MIR15B', 'MIR574', 'LINC-ROR', 'MIR622', 'TRU-TCA1-1', 'SNORA73A', 'MIR99A', 'MIR27B', 'LINC-PINT', 'MIR382', 'MIR182', 'MIR181C', 'MIR497', 'MIR122', 'MIR22', 'MIR485', 'MIR142', 'MIR197', 'MIR1295A', 'MIR146B', 'MIR200B', 'MIR4497', 'MIR3178', 'TTN-AS1', 'MIR134', 'MIR144', 'MIR590', 'MIR361', 'LINC00303', 'LINC00628', 'MIR532', 'MIR663A', 'TALAM1', 'MIR181A1', 'MIR1976', 'MIR1913', 'SNHG19', 'GRASLND', 'LINC00639', 'MIR26A1', 'MIR26B', 'MIR328', 'MIR384', 'MIR496', 'NORAD', 'RN7SK', 'MIR483', 'MIR451A', 'MIR486-1', 'MIR208B', 'MIR133B', 'MIR208A', 'MIR23B', 'MIR19A', 'MIR449B', 'NRON', 'FAS-AS1', 'MIR20A', 'MIR106B', 'MIR301A', 'MIR374A', 'MIR378A', 'MT-RNR2', 'LINC00871', 'CCDC26', 'MIR520E', 'MIR210', 'MIR5703', 'MIR383', 'MIR6879', 'MIR3648-1', 'MIR663B', 'MIR183', 'MIR381', 'MIR200A', 'MIR199A2', 'MIR99B', 'MIR499A', 'MIR184', 'MIR96', 'MIR378B', 'MIR379', 'MIR425', 'MIR135B', 'MIR1295B', 'MIR585', 'MIR503', 'MIR4454', 'MIR200C', 'MIR409', 'MIR16-1', 'SNHG1', 'MIR4513', 'MIR3591', 'MIR3135B', 'MIR377', 'MIR320B1', 'LINC00862', 'LINC02911', 'MIR373', 'MIR23A', 'MIR628', 'MIR505', 'MIR1972-1', 'MIR718', 'MIR3138', 'MIR630', 'MIR575', 'MIR636', 'MIR1265', 'KCNQ1DN', 'MIAT', 'MIR564', 'MIR432', 'MIR572', 'MIR652', 'MIR9-1', 'MIR9-2', 'LSINCT5', 'MIR431', 'MIR1225', 'SNORD87', 'MIR30C1', 'MIR363', 'MIR29C', 'MIR433', 'GRM7-AS3', 'MIR2113', 'MIR33B', 'MIR151A', 'MIR423', 'HCP5', 'MIR130B', 'MIR340', 'LINC01191', 'PWAR4', 'MIR339', 'MIR1248', 'MIR30E', 'LINC02605', 'MIR766', 'MIR20B', 'MIR100', 'MIR193A', 'MIRLET7I', 'LINC01194', 'MIR152', 'MIR504', 'MIR198', 'MIR595', 'MIR25', 'TRR-TCT2-1', 'MIR193B', 'MIR338', 'MIR199B', 'MIR1-1', 'MIR455', 'TDRG1', 'PWAR1', 'MIR494', 'FBXW7-AS1', 'MIR17HG', 'MIR668', 'MIR371A', 'TRI-AAT9-1', 'MIR1538', 'MIR337', 'MIR211', 'MIR214', 'RNU1-1', 'MIR638', 'BCYRN1', 'CARMN', 'SNORA73B', 'LINC00470', 'HIF1A-AS2', 'EGOT', 'MT-TG', 'IFNG-AS1', 'SNORD46', 'LINC01017', 'MIR4535', 'MIR8085', 'MIR6133', 'MIR12136', 'MIR1303', 'MIR181B2', 'MIR181B1', 'MIR93', 'MIR615', 'LINC01080', 'MIR33A', 'LINC02989', 'MIR942', 'MIR4313', 'RMST', 'MIR604', 'TRE-TTC3-1', 'MIR4306', 'MIR4478', 'DISC1FP1', 'MIR2681', 'MIR1915', 'MIR506', 'MIR5787', 'MIR3665', 'MIR3615', 'MIR501', 'MIR1825', 'TTTY15', 'LINC00908', 'LINC00861', 'LINC00996', 'MIR511', 'MIR4639', 'MIR124-1HG', 'PLUT', 'MIR551B', 'MIR4500', 'MIR345', 'PTCSC2', 'MIR3674', 'PCA3', 'MT-TD', 'HOTTIP', 'VTRNA1-3', 'MIR324', 'CCAT1', 'MIR454', 'MIR219A1', 'MIR593', 'MIR598', 'MIR8073', 'MIR6820', 'MIR6794', 'MIR3196', 'MIR744', 'MIR6799', 'MIR323A', 'MIR5188', 'MIR3679', 'ZNF667-AS1', 'MIR429', 'MIR5100', 'MIR7977', 'Glucose', 'Lipopolysaccharides', 'Dietary Fiber', 'Phosphoribosyl Pyrophosphate', 'Hyaluronic Acid', 'Vancomycin', 'Ceramides', 'Starch', 'Pentosephosphates', 'Glycogen', 'Sphingomyelins', 'Fluorodeoxyglucose F18', 'Gentamicins', 'Sugars', 'Galactose', 'Doxorubicin', 'Anthracyclines', 'Polysaccharides', 'Mannose', 'Dextrans', 'Alginates', 'Agar', 'Ascorbic Acid', 'Trehalose', 'Sucrose', 'Heparin', 'Inositol', 'Etoposide', 'Heparitin Sulfate', 'Glycosaminoglycans', 'Maltose', 'Oligosaccharides', 'Aclarubicin', 'Bleomycin', 'Streptozocin', 'Deoxyribose', 'Ginsenosides', 'Lactulose', 'Amino Sugars', 'Sugar Alcohols', 'Sorbitol', 'Xylitol', 'Galactitol', 'Glucosamine', 'Anthocyanins', 'Saponins', 'Heparin, Low-Molecular-Weight', 'Clindamycin', 'Aminoglycosides', 'Inositol Phosphates', 'Teicoplanin', 'Keratan Sulfate', 'Lipid A', 'G(M1) Ganglioside', 'Gangliosides', 'Deoxyglucose', 'Glycosphingolipids', 'Sulfoglycosphingolipids', 'Glyceraldehyde', 'Mannitol', 'Glycolipids', 'Sialic Acids', 'Acetylgalactosamine', 'Cellobiose', 'Isomaltose', 'Lactose', 'Melibiose', 'Dithiothreitol', 'Acarbose', 'Glycosides', 'Ribose', 'Xylose', 'Topiramate', 'Amikacin', 'G(M3) Ganglioside', 'Blood Glucose', 'N-Acetylneuraminic Acid', 'Disaccharides', 'Acetylglucosamine', 'Glucuronic Acid', '2,3-Diphosphoglycerate', 'Inositol 1,4,5-Trisphosphate', 'Monosaccharides', 'Hesperidin', 'Enoxaparin', 'Fondaparinux', 'Tinzaparin', 'Dalteparin', 'Digoxin', 'Dehydroascorbic Acid', 'Nucleosides', 'Chondroitin Sulfates', 'Fructosamine', 'Ouabain', 'Sepharose', 'Canagliflozin', 'Glycerol', 'Glucuronides', 'Glycopeptides', 'Hexoses', 'Alginic Acid', 'Fructose', 'Pentoses', 'Chitosan', 'Tobramycin', 'Phytic Acid', 'Calcium Gluconate', 'Glycosylphosphatidylinositols', 'Glucosinolates', 'Carrageenan', 'Trioses', 'Erythritol', 'Chitin', 'Hexosamines', 'Phlorhizin', 'Lincomycin', 'Cellulose', 'Fucose', 'Zanamivir', 'Lincosamides', 'Globosides', 'Chondroitin', 'Ristocetin', 'Lignin', 'Ferric Oxide, Saccharated', 'Daunorubicin', 'Adenosine Diphosphate Ribose', 'Rhamnose', 'Isosorbide Dinitrate', 'Glucosylceramides', 'Tragacanth', 'Icodextrin', 'Chromomycin A3', 'Holothurin', 'Glycerylphosphorylcholine', 'Streptomycin', 'Arbutin', 'Cardenolides', 'Glycerophosphates', 'Epirubicin', 'Cerebrosides', 'Glyceryl Ethers', 'Psychosine', 'Puromycin Aminonucleoside', 'Teniposide', 'Pentosan Sulfuric Polyester', 'Atractyloside', 'Hypromellose Derivatives', 'Teichoic Acids', 'Puromycin', 'Digitonin', 'Idarubicin', 'Arabinose', 'Diatrizoate Meglumine', 'Heptoses', 'Deoxy Sugars', 'Meglumine', 'Dermatan Sulfate', 'Acetyldigoxins', 'Nadroparin', 'Spectinomycin', 'Neomycin', 'Plicamycin', 'O-Acetyl-ADP-Ribose', 'Neuraminic Acids', 'Sugar Phosphates', 'Quillaja Saponins', 'Lactosylceramides', 'Phospholipid Ethers', 'Uronic Acids', 'Sucralfate', 'Digitalis Glycosides', 'Netilmicin', 'Glucans', 'Dihydroxyacetone Phosphate', 'Digitoxin', 'Chromomycins', 'Heparinoids', 'Dibekacin', 'Glucosides', 'Trisaccharides', 'Meglumine Antimoniate', 'Dietary Carbohydrates', '3-O-Methylglucose', 'Kanamycin', 'Galactosides', 'Nucleotides', 'Glucaric Acid', 'Novobiocin', 'Glucose-6-Phosphate', 'Tetroses', 'Ketoses', 'Galactolipids', 'Paromomycin', 'Medigoxin', 'Metrizamide', 'Guanosine Diphosphate Mannose', 'Hexuronic Acids', 'Hexosephosphates', 'Galactosamine', 'Adenosine Diphosphate Glucose', 'O Antigens', 'Raffinose', 'Galactans', 'Tartrates', 'Diphosphoglyceric Acids', 'Mannans', 'G(M2) Ganglioside', 'Cyclic ADP-Ribose', 'Erythrityl Tetranitrate', 'Cholesterol', 'Phospholipids', 'Phosphatidylcholines', 'Phosphatidylserines', 'Docosahexaenoic Acids', 'Triglycerides', 'Menthol', 'Sphingolipids', 'Fatty Acids, Nonesterified', 'Fatty Acids, Omega-3', 'Cholesterol Esters', 'Fatty Acids, Unsaturated', 'Eicosapentaenoic Acid', 'Arachidonic Acid', 'Fatty Acids', 'Fatty Acids, Monounsaturated', 'Lysophosphatidylcholines', 'Lipid Peroxides', 'Cholecalciferol', 'Fatty Acids, Volatile', 'alpha-Linolenic Acid', 'Linoleic Acid', 'Oleic Acid', 'Oils, Volatile', 'Oils', 'Dinoprostone', 'Sterols', 'Thromboxane A2', 'Epoprostenol', 'Prostaglandins', 'Lipofuscin', 'Sodium Dodecyl Sulfate', 'Butyrates', 'Calcifediol', 'Capsaicin', 'Fatty Acids, Omega-6', 'Fusidic Acid', 'Phytosterols', 'Endocannabinoids', 'Lipid Bilayers', 'Phosphatidylglycerols', 'Eucalyptol', '3-Hydroxybutyric Acid', 'Glycerophospholipids', 'Calcitriol', 'Diglycerides', 'Phosphatidylinositols', 'Tramadol', 'Valproic Acid', 'Atorvastatin', 'Fatty Acids, Essential', 'Dolichols', 'Monoglycerides', 'Thromboxanes', '15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid', 'Mycophenolic Acid', 'Rapeseed Oil', 'Fats', 'Acetic Acid', 'Castor Oil', 'Palmitates', 'Hexanols', 'Daptomycin', 'Thioctic Acid', 'Phosphatidylethanolamines', 'Fluvastatin', 'Cardiolipins', 'Acetates', 'Propionates', 'Fish Oils', 'F2-Isoprostanes', 'Margarine', 'Butyric Acid', 'Palm Oil', 'Linolenic Acids', 'Venlafaxine Hydrochloride', 'Bimatoprost', 'gamma-Linolenic Acid', '8,11,14-Eicosatrienoic Acid', 'Cholestanol', 'Trans Fatty Acids', '1-Butanol', 'Prostaglandins A', 'Ergocalciferols', 'Cod Liver Oil', 'Palmitic Acid', 'Myristic Acid', 'Leukotrienes', 'Hydroxycholecalciferols', 'Turpentine', 'Withanolides', 'Phosphatidylinositol 4,5-Diphosphate', 'Isoprostanes', 'Misoprostol', 'Prostaglandins I', 'Eicosanoids', 'Lysophospholipids', 'Lecithins', 'Oxysterols', 'Thromboxane B2', 'Prostaglandin D2', 'Corn Oil', 'Ionomycin', 'Latanoprost', 'Iloprost', 'Ethiodized Oil', 'Caspofungin', 'Prostaglandins E', 'Dinoprost', 'Ceroid', '25-Hydroxyvitamin D 2', 'Phosphatidic Acids', 'Linseed Oil', 'Sodium Tetradecyl Sulfate', 'Dolichol Phosphates', 'Plant Oils', 'Oxylipins', 'Isobutyrates', 'Prostaglandins, Synthetic', 'Travoprost', 'Desvenlafaxine Succinate', 'Prostaglandins F', '24,25-Dihydroxyvitamin D 3', 'Olive Oil', 'Octanols', 'Arachidonic Acids', '6-Ketoprostaglandin F1 alpha', 'Alprostadil', 'Coconut Oil', 'Prostaglandins G', 'Phosphatidylinositol Phosphates', 'Micafungin', 'Butanols', 'Hydroxyeicosatetraenoic Acids', 'Dehydrocholesterols', 'Lanosterol', 'Sodium Oxybate', 'Prostaglandin H2', 'Leukotriene B4', 'Lanolin', '12-Hydroxy-5,8,10,14-eicosatetraenoic Acid', 'Soybean Oil', 'Lipoxins', 'Lipopeptides', 'Cilastatin, Imipenem Drug Combination', 'Sorbic Acid', 'tert-Butyl Alcohol', 'Glycerides', 'Gemfibrozil', 'Neuroprostanes', 'Stigmasterol', 'Heptanoates', 'Palmitoyl Coenzyme A', 'Fats, Unsaturated', 'Oleic Acids', 'Stearates', 'Valerates', 'Waxes', 'Sesame Oil', 'Prostaglandin Endoperoxides', 'Cloprostenol', 'Linoleic Acids', 'Farnesol', 'Mupirocin', 'Leukotriene C4', 'Dimyristoylphosphatidylcholine', 'Dihydroxycholecalciferols', 'Dihydrotachysterol', 'Croton Oil', 'Polymyxin B', 'Stearic Acids', 'Hydroxycholesterols', 'Heptanoic Acids', 'Lauric Acids', 'Erucic Acids', 'Hydroxybutyrates', 'Glutathione', 'Cyclosporine', 'Glatiramer Acetate', 'Exenatide', 'Thyrotropin', 'Ghrelin', 'Oxytocin', 'Dipeptides', 'Teriparatide', 'Glutathione Disulfide', 'Echinocandins', 'Luteinizing Hormone', 'Lisinopril', 'Octreotide', 'Sincalide', 'Dactinomycin', 'Insulin Glargine', 'Anserine', 'Insulin Detemir', 'Enalapril', 'Enalaprilat', 'Polyglutamic Acid', 'Insulin Lispro', 'S-Nitrosoglutathione', 'Atazanavir Sulfate', 'Parathyroid Hormone', 'Streptogramin B', 'Certolizumab Pegol', 'Relaxin', 'Menotropins', 'Aspartame', 'Streptogramins', 'Cholecystokinin', 'Phalloidine', 'Insulin Aspart', 'Acetylmuramyl-Alanyl-Isoglutamine', 'Follicle Stimulating Hormone', 'Abciximab', 'Bacitracin', 'N-Formylmethionine Leucyl-Phenylalanine', 'C-Peptide', 'Thymic Factor, Circulating', 'Phosphopeptides', 'Anidulafungin', 'Thyrotropin, beta Subunit', 'Cyclosporins', 'Polylysine', 'Distamycins', 'Polygeline', 'Valinomycin', 'Growth Hormone', 'Prolactin', 'Peptichemio', 'Alpha-Amanitin', 'Oligopeptides', 'Eptifibatide', 'Peptides, Cyclic', 'Tetragastrin', 'Charybdotoxin', 'Pentagastrin', 'Atrial Natriuretic Factor', 'Capreomycin', 'Viomycin', 'Angiotensins', 'Insulin', 'Fas Ligand Protein', 'Arginine Vasopressin', 'N-substituted Glycines', 'Angiotensin II', 'Defensins', 'alpha-Defensins', 'beta-Defensins', 'Microcystins', 'Echinomycin', 'Salivary Cystatins', 'Carnosine', 'Myostatin', 'Insulin, Isophane', 'Leuprolide', 'Chalones', 'Nisin', 'Trimethoprim, Sulfamethoxazole Drug Combination', 'Amoxicillin-Potassium Clavulanate Combination', 'Piperacillin, Tazobactam Drug Combination', 'Ezetimibe, Simvastatin Drug Combination', 'Aminophylline', 'Crack Cocaine', 'Dimenhydrinate', 'Lidocaine, Prilocaine Drug Combination', 'Silica Gel', 'Artemether, Lumefantrine Drug Combination', 'Ophthalmic Solutions', 'Aerosols', 'Buprenorphine, Naloxone Drug Combination', 'Fluticasone-Salmeterol Drug Combination', 'Denosumab', 'Cetuximab', 'Infliximab', 'Palivizumab', 'Rituximab', 'Nivolumab', 'Ipilimumab', 'Trastuzumab', 'Adalimumab', 'Bevacizumab', 'Ranibizumab', 'Omalizumab', 'Checkpoint Kinase 1', 'Alemtuzumab', 'Natalizumab', 'Panitumumab', 'Ustekinumab', 'Basiliximab', 'Daclizumab', 'Platelet Factor 3', 'Receptor-CD3 Complex, Antigen, T-Cell', 'Ki-67 Antigen', 'Variant Surface Glycoproteins, Trypanosoma', 'Lysosomal-Associated Membrane Protein 2', 'Leukocyte Common Antigens', 'Activated-Leukocyte Cell Adhesion Molecule', 'Factor Va', 'Phytochrome A', 'Aflatoxins', 'Tetrodotoxin', 'Muscimol', 'Zearalenone', 'Okadaic Acid', 'Aflatoxin B1', 'Aflatoxin M1', 'Cytochalasin B', 'Gliotoxin', 'Ibotenic Acid', 'Trichothecenes', 'Mycotoxins', 'rs11549465', 'rs4341', 'rs7460', 'rs2070802', 'rs17421511', 'rs10783485', 'rs1800169', 'rs1801131', 'rs1537516', 'rs7832552', 'rs1805086', 'rs1800012', 'rs9939609', 'rs17622656', 'rs9536314', 'rs9527025', 'rs202178565', 'rs2016347', 'rs28933979', 'rs1799945', 'rs429358', 'rs7412', 'rs113488022', 'rs58912633', 'rs2854116', 'rs2854117', 'rs780093', 'rs780094', 'rs1260362', 'rs738409', 'rs2294918', 'rs2281135', 'rs1107946', 'rs671', 'rs732314', 'rs28366133', 'rs144851946', 'rs1396533675', 'rs75733498', 'rs10417628', 'rs550122918', 'rs13120336', 'rs77375493', 'rs577912', 'rs564481', 'rs7955866', 'rs35767', 'rs1800629', 'rs1800795', 'rs755622', 'rs1007888', 'rs180795', 'rs10734411', 'rs387907264', 'rs121913615', 'rs7902929', 'rs2603462', 'rs7561528', 'rs6733839', 'rs10164112', 'rs1057233', 'rs7038172', 'rs2108622', 'rs763252884', 'rs6808178', 'rs115185635', 'rs12497850', 'rs34311866', 'rs3793947', 'rs11060180', 'rs9568188', 'rs2069837', 'rs13306435', 'rs1937', 'rs117530284', 'rs226794', 'rs3027178', 'rs12596324', 'rs6311', 'rs6313', 'rs690705', 'rs1990622', 'rs5848', 'rs779597655', 'rs80358273', 'rs8176719', 'rs687621', 'rs643434', 'rs505922', 'rs121434369', 'rs2687201', 'rs1815739', 'rs2075650', 'rs2032582', 'rs2073618', 'rs3134069', 'rs3134070', 'rs3102735', 'rs4077561', 'rs1805754', 'rs4964779', 'rs406113', 'rs2281082', 'rs974334', 'rs79658334', 'rs17415557', 'rs6056209', 'rs7121', 'rs1800857', 'rs10814274', 'rs17746510', 'rs5645', 'rs1883025', 'rs7503726', 'rs97384', 'rs31574', 'rs6453647', 'rs11135857', 'rs74659977', 'rs58596362', 'rs17081935', 'rs28365927', 'rs2802292', 'rs2764264', 'rs13217795', 'rs13231195', 'rs9400239', 'rs1260326', 'rs16998073', 'rs2943656', 'rs9991501', 'rs2287926', 'rs4842924', 'rs9936385', 'rs2934656', 'rs1801133', 'rs201118034', 'rs11591147', 'rs36212733', 'rs71556729', 'rs35709627', 'rs71556736', 'rs55673514', 'rs6265', 'rs1800469', 'rs1800470', 'rs1982073', 'rs371425292', 'rs572842823', 'rs4149056', 'rs7709243', 'rs6664221', 'rs10881463', 'rs4130113', 'rs387907272', 'rs104893878', 'rs12212067', 'rs12206094', 'rs2184061', 'rs6025', 'rs1799963', 'rs2075800', 'rs2227956', 'rs1043618', 'rs2763979', 'rs1061170', 'rs74827081', 'rs53576', 'rs2420915', 'rs6430491', 'rs2593704', 'rs1907240', 'rs2257129', 'rs2076260', 'rs121434569', 'rs632793', 'rs41300100', 'rs1799983', 'rs2070744', 'rs397514694', 'rs760920350', 'rs138684936', 'rs25487', 'rs4702', 'rs61748181', 'rs63750424', 'rs34208370', 'rs1046896', 'rs1063192', 'rs760391069', 'rs140092351', 'rs1409962577', 'rs2736100', 'rs7726159', 'rs10069690', 'rs2853669', 'rs12696304', 'rs16847897', 'rs10936599', 'rs61753924', 'rs7843014', 'rs121913273', 'rs3750846', 'rs570618', 'rs10922109', 'rs9923231', 'rs9934488', 'rs2296241', 'rs495392', 'rs10848087', 'rs2722372', 'rs7523', 'rs3746625', 'rs988583', 'rs6277', 'rs2295080', 'rs11121704', 'rs1057079', 'rs1064261', 'rs573775', 'rs11246867', 'rs3088051', 'rs10902469', 'rs73105013', 'rs10277', 'rs10830963', 'rs33939927', 'rs34637584', 'rs35870237', 'rs7133914', 'rs33949390', 'rs34778348', 'rs4946936', 'rs11769597', 'rs4988300', 'rs634008', 'rs75932628', 'rs9315202', 'rs7783012', 'rs4732724', 'rs1402972626', 'rs1483581212', 'rs187456378', 'rs17847577', 'rs4531631', 'rs2908007', 'rs1800796', 'rs754486509', 'rs74315408', 'rs56984562', 'rs1994336', 'rs10994359', 'rs104893877', 'rs768838511', 'rs749476922', 'rs1695', 'rs2228001', 'rs11615', 'rs2571244', 'rs57875989', 'rs59733750', 'rs7680591', 'rs57965306', 'rs9898', 'rs72645347', 'rs724561', 'rs751056896', 'rs5882', 'rs708272', 'rs3764261', 'rs1800775', 'rs2303790', 'rs1800624', 'rs1800625', 'rs1558139', 'rs7756935', 'rs1421368', 'rs1805017', 'rs4498351', 'rs28366003', 'rs10636', 'rs1610216', 'rs11574697', 'rs12041331', 'rs1057519783', 'rs75527207', 'rs78655421', 'rs4404327', 'rs63750231', 'rs919741', 'rs1514283', 'rs4646155', 'rs4646176', 'rs2285666', 'rs879922', 'rs78973108', 'rs137854618', 'rs140637', 'rs1444261', 'rs1801232', 'rs12243326', 'rs4132670', 'rs2253310', 'rs17630266', 'rs2755213', 'rs2755209', 'rs398122403', 'rs1060499619', 'rs1286247510', 'rs17070145', 'rs6439886', 'rs6967117', 'rs4725617', 'rs1800801', 'rs3917225', 'rs2234650', 'rs4141134', 'rs2071008', 'rs1917760', 'rs63751273', 'rs34245038', 'rs140593', 'rs174547', 'rs2231142', 'rs3733591', 'rs893006', 'rs2231143', 'rs4147929', 'rs114241159', 'rs2910164', 'rs2431697', 'rs464553', 'rs1028883', 'rs3129753', 'rs4870044', 'rs80356717', 'rs3851179', 'rs8176746', 'rs421016', 'rs4880', 'rs12785878', 'rs10741657', 'rs6013897', 'rs2282679', 'rs207128', 'rs207060', 'rs17847095', 'rs5068', 'rs142380904', 'rs353291', 'rs2222722', 'rs1889470', 'rs863224946', 'rs1060499542', 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'rs1800849', 'rs11046966', 'rs1143623', 'rs3754032', 'rs238358', 'rs20417', 'rs1042114', 'rs700752', 'rs1065656', 'rs4234798', 'rs61752717', 'rs1764391', 'rs5326', 'rs265975', 'rs9347683', 'rs1799811', 'rs2284367', 'rs1155563', 'rs10877012', 'rs4646536', 'rs753529', 'rs1127568', 'rs7604576', 'rs4730250', 'rs2854464', 'rs2287921', 'rs225717', 'rs10774625', 'rs17421627', 'rs9945493', 'rs4669573', 'rs10197851', 'rs11711889', 'rs1117750', 'rs7908652', 'rs7943316', 'rs2242466', 'rs5569', 'rs4646', 'rs13048019', 'rs3849942', 'rs699', 'rs11548779', 'rs1699102', 'rs2282649', 'rs1010159', 'rs63750526', 'rs60369023', 'rs281875362', 'rs4641', 'rs833069', 'rs2071559', 'rs597668', 'rs2245121', 'rs911887', 'rs6413520', 'rs721917', 'rs7078012', 'rs12720208', 'rs4387287', 'rs4452212', 'rs4149573', 'rs1008438', 'rs121434416', 'rs121434415', 'rs3851059', 'rs7087728', 'rs104894833', 'rs121913050', 'rs121434491', 'rs10818488', 'rs2416808', 'rs266729', 'rs7799039', 'rs1042615', 'rs1801270', 'rs1059234', 'rs104893875', 'rs480575', 'rs1001179', 'rs2300181', 'rs4054823', 'rs2208454', 'rs763222419', 'rs2276109', 'rs144848', 'rs1801406', 'rs1805097', 'rs121964971', 'rs150840924', 'rs10149689', 'rs12050077', 'rs1711437', 'rs1800206', 'rs768250675', 'rs17655652', 'rs41279633', 'rs2072183', 'rs217434', 'rs373897970', 'rs4988514', 'rs1776180', 'rs63751235', 'rs5744256', 'rs9568232', 'rs1144393', 'rs16930692', 'rs7955200', 'rs10771283', 'rs267607613', 'rs12289502', 'rs9665943', 'rs1073810', 'rs6254', 'rs121909715', 'rs716508', 'rs7272891', 'rs1997794', 'rs2235751', 'rs910080', 'rs2229765', 'rs1172822', 'rs236114', 'rs7333181', 'rs12425791', 'rs939915', 'rs4073591', 'rs4073590', 'rs11040489', 'rs4930001', 'rs800140', 'rs16928120', 'rs104893768', 'rs8078340', 'rs267606915', 'rs762842457', 'rs2281939', 'rs1799884', 'rs2929970', 'rs1805415', 'rs61755783', 'rs61755793', 'rs28384991', 'rs12272004', 'rs3135506', 'rs2814778', 'rs9332739', 'rs1800255', 'rs174537', 'rs953413', 'rs4841322', 'rs6822', 'rs2234919', 'rs1406830873', 'rs1991517', 'rs121909053', 'rs10757274', 'rs7595412', 'rs892515', 'rs9789480', 'rs3771362', 'rs2288377', 'rs5742612', 'rs867186', 'rs2069901', 'rs4857343', 'rs2069948', 'rs121918339', 'rs121909208', 'rs1138272', 'rs1041981', 'rs3731566', 'rs4140564', 'rs74315452', 'rs118192162', 'rs1143627', 'rs1979277', 'rs780050909', 'rs10040427', 'rs72552732', 'rs77300588', 'rs774792831', 'rs28383481', 'rs11568520', 'rs11568514', 'rs11568513', 'rs11568524', 'rs11568525', 'rs1805009', 'rs505151', 'rs892086', 'rs2066470', 'rs4846048', 'rs3737964', 'rs3783799', 'rs2230500', 'rs1709183', 'rs1800234', 'rs72544141', 'rs66785829', 'rs121912706', 'rs4943794', 'rs2374983', 'rs6910534', 'rs3751591', 'rs1131497', 'rs1970546', 'rs8179176', 'rs1256065', 'rs1256030', 'rs728524', 'rs1255998', 'rs3918242', 'rs8179090', 'rs235754', 'rs235710', 'rs747052707', 'rs56149945', 'rs909253', 'rs771552960', 'rs776197495', 'rs2830102', 'rs2300403', 'rs11575937', 'rs28928902', 'rs1332784619', 'rs1334067073', 'rs59885338', 'rs63750570', 'rs113436208', 'rs5051', 'rs4762', 'rs5498', 'rs7551175', 'rs30187', 'rs143383', 'rs2255991', 'rs1389523308', 'rs1801252', 'rs121908448', 'rs34612342', 'rs36053993', 'rs143353451', 'rs121908380', 'rs662799', 'rs12885300', 'rs6688832', 'rs199951903', 'rs121912691', 'rs2073617', 'rs3798577', 'rs2606345', 'rs1799941', 'rs539528262', 'rs377767406', 'rs185847354', 'rs786201443', 'rs1800947', 'rs34221221', 'rs17602729', 'rs2333227', 'rs61733139', 'rs2542052', 'rs1403543', 'rs9282861', 'rs1222522967', 'rs1799964', 'rs1800871', 'rs28940578', 'rs28940579', 'rs11739136', 'rs846911', 'rs12086634', 'rs846910', 'rs1570360', 'rs2010963', 'rs821616', 'rs2146881', 'rs777902199', 'rs529588584', 'rs387906396', 'rs200606989', 'rs56199535', 'rs1226153645', 'rs61282106', 'rs59981161', 'rs57830985', 'rs56657623', 'rs59914820', 'rs28928900', 'rs56793579', 'rs1498608', 'rs920832709', 'rs1799864', 'rs60934003', 'rs1479320041', 'rs1799814', 'rs4646903', 'rs1136201', 'rs1305821086', 'rs8191979', 'rs1204100257', 'rs121909210', 'rs17125721', 'rs1225178489', 'rs63750306', 'rs1800925', 'rs1800730', 'rs231775', 'rs121912288', 'rs2214102', 'rs2066479', 'rs5030868', 'rs80356682', 'rs1255283120', 'rs199422243', 'rs121912304', 'rs1273172387', 'rs1805085', 'rs1799807', 'rs61754278', 'rs104894139', 'rs1799929', 'rs1799931', 'rs1801279', 'rs1801278', 'rs2854746', 'rs2292354', 'rs62399430', 'rs58542926', 'rs6785049', 'rs2276707', 'rs1128503', 'rs2228570', 'rs228679', 'rs228570', 'rs201141490', 'rs183444295', 'rs17601696', 'rs1434459568', 'rs1885472', 'rs1760904', 'rs1713418', 'rs57629361', 'rs267607621', 'rs267607547', 'rs35074065', 'rs12329760', 'rs333', 'rs763110', 'rs2279115', 'rs4645878', 'rs534125149', 'rs201988637', 'rs1306430934', 'rs201286427', 'rs774822330', 'rs281865082', 'rs6449182', 'rs45573936', 'rs1389340786', 'rs1188451775', 'rs11541794', 'rs199473071', 'rs1800668', 'rs79662648', 'rs76436625', 'rs10263573', 'rs3815221', 'rs7794637', 'rs7784168', 'rs4383910', 'rs7782354', 'rs251796', 'rs344152214', 'rs7205764', 'rs7453920', 'rs73555604', 'rs12666606', 'rs1537371', 'rs6475609', 'rs145265196', 'rs11679458', 'rs11848300', 'rs1189312', 'rs11189312', 'rs10882883', 'rs17108378', 'rs35077384', 'rs10509637', 'rs10509639', 'rs174579', 'rs174626', 'rs12721046', 'rs8187710', 'rs1289543302', 'rs763089663', 'rs771375988', 'rs80356740', 'rs9697983', 'rs1047891', 'rs149693840', 'rs121913520', 'rs121913512', 'rs4293393', 'rs56105708', 'rs34833812', 'rs2227306', 'rs764967314', 'rs779188078', 'rs74315489', 'rs2549794', 'rs2248374', 'rs121918304', 'rs5743708', 'rs1834481', 'rs2043211', 'rs1883832', 'rs10499563', 'rs2236225', 'rs559884313', 'rs57318642', 'rs991967', 'rs2070600', 'rs6475604', 'rs768883316', 'rs560997634', 'rs201159862', 'rs751170930', 'rs756737634', 'rs146991645', 'rs1601703288', 'rs1927830489', 'rs1927831624', 'rs764947941', 'rs752242172', 'rs73195521', 'rs781378335', 'rs756597390', 'rs780478736', 'rs148006212', 'rs768583671', 'rs34949484', 'rs146766120', 'rs111522866', 'rs3875089', 'rs3763040', 'rs335929', 'rs3794396', 'rs576696900', 'rs760632', 'rs1274412848', 'rs11030101', 'rs28722151', 'rs74315431', 'rs121913530', 'rs13030825', 'rs104893736', 'rs964184', 'rs769446', 'rs121912678', 'rs121913507', 'rs111033565', 'rs113993960', 'rs2167270', 'rs3749034', 'rs73885319', 'rs1425706422', 'rs1409112179', 'rs267607161', 'rs28933981', 'rs121918098', 'rs17173608', 'rs2236242', 'rs120074195', 'rs121912438', 'rs121909671', 'rs150991803', 'rs713993048', 'rs141138948', 'rs121908012', 'rs544850971', 'rs10895068', 'rs754875934', 'rs112029032', 'rs113993959', 'rs77010898', 'rs121908755', 'rs28931614', 'rs371323516', 'rs147750704', 'rs587777300', 'rs121434591', 'rs1427407', 'rs66650371', 'rs198389', 'rs1390860312', 'rs730881394', 'rs314277', 'rs314280', 'rs365132', 'rs121908668', 'rs5754227', 'rs869312966', 'rs121908253', 'rs34159654', 'rs75541969', 'rs121908033', 'rs137852802', 'rs28999110', 'rs139329533', 'rs281875364', 'rs1302383392', 'rs63750004', 'rs1057519896', 'rs1057519895', 'rs12148337', 'rs776878433', 'rs1261281771', 'rs945270', 'rs121913514', 'rs1726866', 'rs10246939', 'rs104894584', 'rs35801418', 'rs80338903', 'rs1420175614', 'rs118204453', 'rs775191124', 'rs3742330', 'rs14035', 'rs9623117', 'rs197412', 'rs121913227', 'rs1879282', 'rs80356676', 'rs763122825', 'rs28934568', 'rs7137828', 'rs17514846', 'rs1218889239', 'rs12806698', 'rs2290707', 'rs6296', 'rs1236246272', 'rs55796513', 'rs193922916', 'rs318240735', 'rs1225055065', 'rs753688777', 'rs12478601', 'rs2059807', 'rs4784165', 'rs2479106', 'rs13429458', 'rs10818854', 'rs142993240', 'rs991612107', 'rs745805222', 'rs1361108', 'rs897798', 'rs769450', 'rs189596789', 'rs79972789', 'rs181686584', 'rs11604207', 'rs562787662', 'rs28714259', 'rs75391579', 'rs540839115', 'rs886039762', 'rs12907866', 'rs17601241', 'rs771753477', 'rs746319045', 'rs120074192', 'rs145588689', 'rs2853672', 'rs1064608', 'rs10838738', 'rs12628329', 'rs1800471', 'rs1800468', 'rs143507827', 'rs1184398243', 'rs10503929', 'rs9426', 'rs10418', 'rs1051296', 'rs16862199', 'rs2070358', 'rs12273124', 'rs121913500', 'rs2710873', 'rs71608359', 'rs769499327', 'rs119103229', 'rs1158898827', 'rs559155109', 'rs267607996', 'rs3093061', 'rs3093062', 'rs137853238', 'rs752732851', 'rs138594222', 'rs104886142', 'rs371584776', 'rs866236602', 'rs137852412', 'rs5743618', 'rs267607040', 'rs2209972', 'rs132630304', 'rs769417218', 'rs121912431', 'rs113430717', 'rs3020136', 'rs79784106', 'rs140146885', 'rs11031006', 'rs104895094', 'rs375511250', 'rs1229568621', 'rs372749193', 'rs730880031', 'rs587777574', 'rs79781594', 'rs149744081', 'rs1249016772', 'rs63750652', 'rs2770378', 'rs386833395', 'rs80357906', 'rs786204278', 'rs80359550', 'rs74799832', 'rs121909342', 'rs104894201', 'rs2132039', 'rs587776551', 'rs587782652', 'rs3746266', 'rs6510997', 'rs201866415', 'rs769551404', 'rs1239009061', 'rs560657112', 'rs758978788', 'rs377112763', 'rs1011490341', 'rs121964845', 'rs1135401754', 'rs398123414', 'rs763880042', 'rs1135401755', 'rs527640350', 'rs1135401756', 'rs1135401757', 'rs35036378', 'rs201739205', 'rs183433761', 'rs367732974', 'rs549591993', 'rs200487063', 'rs34104384', 'rs35518301', 'rs72661131', 'rs562962093', 'rs397509430', 'rs33980857', 'rs34598529', 'rs33931746', 'rs33981098', 'rs34500389', 'rs63750953', 'rs281864525', 'rs34166473', 'rs201381696', 'rs371267954', 'rs9904779', 'rs2073438', 'rs11571340', 'rs434473', 'rs2307214', 'rs312462', 'rs838133', 'rs587782529', 'rs28937900', 'rs1064793515', 'rs12979860', 'rs8099917', 'rs17468277', 'rs10941679', 'rs777523310', 'rs747713929', 'rs371769427', 'rs141688754', 'rs1799990', 'rs104894743', 'rs200902980', 'rs1403572095', 'rs606231296', 'rs371194629', 'rs1063320', 'rs806368', 'rs6902771', 'rs7774230', 'rs3020449', 'rs2229774', 'rs7853758', 'rs17863783', 'rs104894021', 'rs773902', 'rs1044396', 'rs7141087', 'rs6542680', 'rs8178616', 'rs147110934', 'rs815625', 'rs63750001', 'rs80356484', 'rs7736552', 'rs11074029', 'rs117496040', 'rs7647863', 'rs9939224', 'rs56156922', 'Hearing Loss', 'Psychomotor Disorders', 'Death', 'Psychomotor Agitation', 'Pain', 'Dementia', 'Delirium', 'Muscular Dystrophy, Duchenne', 'Heart Failure', 'Inflammation', 'Renal Insufficiency, Chronic', 'Renal Insufficiency', 'Fibrosis', 'Kidney Diseases', 'Diabetic Nephropathies', 'Vascular Calcification', 'Urinary Bladder Neoplasms', 'Brain Neoplasms', 'Neoplasms', 'Neoplasm Metastasis', 'Marfan Syndrome', 'Heart Arrest', 'Paresis', 'Neuromuscular Diseases', 'Hypertension', 'Diabetes Mellitus', 'Hyperlipidemias', 'Myocardial Infarction', 'Stroke', 'Hip Fractures', 'Fractures, Bone', 'Cerebral Infarction', 'Infarction', 'Brain Infarction', 'Hypoproteinemia', 'Anemia', 'Venous Thrombosis', 'Pneumonia', 'Stomach Diseases', 'Ulcer', 'Respiratory Tract Diseases', 'Asthma', 'Alzheimer Disease', 'Sarcopenia', 'Hematologic Neoplasms', 'Leukemia, Myeloid', 'Myelodysplastic Syndromes', 'Leukemia, Myeloid, Acute', 'Ovarian Diseases', 'Cardiovascular Diseases', 'Cerebrovascular Disorders', 'Neurodegenerative Diseases', 'Ovarian Neoplasms', 'Immune System Diseases', 'Breast Neoplasms', 'Rupture', 'Neurologic Manifestations', 'Cardiomegaly', 'Cardiomyopathy, Hypertrophic', 'Heart Failure, Diastolic', 'Headache Disorders, Secondary', 'Dry Eye Syndromes', 'Sleep Wake Disorders', 'Myopia', 'Hyperopia', 'Muscular Diseases', 'Brain Diseases', 'Akathisia, Drug-Induced', 'Constipation', 'Acute Kidney Injury', 'Acute Coronary Syndrome', 'Vasculitis', 'Autoimmune Diseases', 'Giant Cell Arteritis', 'Aortic Arch Syndromes', 'Charles Bonnet Syndrome', 'Lung Neoplasms', 'Vasospasm, Intracranial', 'Hemorrhage', 'Dysentery', 'Adenomatous Polyposis Coli', 'Gray Platelet Syndrome', 'Genetic Diseases, Inborn', 'Syncope', 'Death, Sudden, Cardiac', 'Late Onset Disorders', "Sjogren's Syndrome", 'Nervous System Diseases', 'Lymphoma, Non-Hodgkin', 'Xerostomia', 'Postpartum Hemorrhage', 'Infections', 'Sepsis', 'Drug-Related Side Effects and Adverse Reactions', 'Frailty', 'Chediak-Higashi Syndrome', 'Osteoporotic Fractures', 'Fatigue', 'Hearing Disorders', 'Arterial Occlusive Diseases', 'Infarction, Middle Cerebral Artery', 'Job Syndrome', 'Tremor', 'Atrial Fibrillation', 'Thromboembolism', 'Intracranial Hemorrhages', 'Hypotension, Orthostatic', 'Malnutrition', 'Urinary Incontinence', 'Fever', 'Signs and Symptoms, Respiratory', 'Central Nervous System Diseases', 'Parkinson Disease', 'Amyotrophic Lateral Sclerosis', 'Ocular Hypertension', 'Glaucoma', 'Obesity', 'Plaque, Amyloid', 'Cerebral Amyloid Angiopathy', 'Cystic Fibrosis', 'Obesity, Abdominal', 'Arthritis', 'Dementia, Vascular', 'Cough', 'Respiratory Distress Syndrome', 'Dysautonomia, Familial', 'Coronary Artery Disease', 'Communicable Diseases', 'Diarrhea', 'Vomiting', 'Sialic Acid Storage Disease', 'Wounds and Injuries', 'Bone Diseases', 'Hematoma', 'Polyuria', 'Pituitary Diseases', 'Femoral Fractures', 'Pain, Postoperative', 'Musculoskeletal Pain', 'Low Back Pain', 'Premenstrual Syndrome', 'Hernia, Ventral', 'Pelvic Neoplasms', 'Liver Diseases', 'Osteomalacia', 'Sudden Infant Death', 'Bradycardia', 'Immunologic Deficiency Syndromes', 'Acquired Immunodeficiency Syndrome', 'Dyslipidemias', 'Viremia', 'HIV Infections', 'Periodontal Diseases', 'Chronic Disease', 'Cardiac Output, Low', 'Mitochondrial Diseases', 'Heart Diseases', 'Cataract', 'Hyperglycemia', 'Pulmonary Disease, Chronic Obstructive', 'Liver Neoplasms', 'Osteoporosis', 'Drug Hypersensitivity', 'Muscle Weakness', 'Infertility, Female', 'Coma', 'Craniocerebral Trauma', 'Memory Disorders', 'Ataxia', 'Seizures', 'Lung Diseases', 'Lung Diseases, Interstitial', 'Hypoxia', 'Sarcoidosis', 'Idiopathic Pulmonary Fibrosis', 'Sleep Apnea Syndromes', 'Parkinson Disease, Secondary', 'Acute Lung Injury', 'Chronic Kidney Disease-Mineral and Bone Disorder', 'Genu Valgum', 'Hypotension', 'Osteogenesis Imperfecta', 'Fasciculation', 'Discitis', 'Spondylitis', 'Periodontitis', 'Mastocytosis, Systemic', 'Coinfection', 'Blindness', 'Vision Disorders', 'Eye Diseases', 'Atherosclerosis', 'Hypothalamic Neoplasms', 'Neck Pain', 'Refractive Errors', 'Prediabetic State', 'Psychoses, Substance-Induced', 'Hallucinations', 'Adrenal Insufficiency', 'Muscular Atrophy', 'Atrophy', 'Erythema', 'Skin Diseases', 'Leukemia', 'Colorectal Neoplasms', 'Carcinoma, Hepatocellular', 'Respiratory Tract Infections', 'Neuroblastoma', 'Pneumonia, Pneumocystis', 'Kidney Failure, Chronic', 'Skin Neoplasms', 'Melanoma', 'Muscular Disorders, Atrophic', 'Keratosis', 'Hypertrophy', 'Pigmentation Disorders', 'Carcinoma, Squamous Cell', "Hutchinson's Melanotic Freckle", 'Disorders of Sex Development', 'Heart Valve Diseases', 'Rheumatic Heart Disease', 'Aortic Valve Insufficiency', 'Mitral Valve Insufficiency', 'Tricuspid Valve Insufficiency', 'Endocarditis', 'Multiple Sclerosis', 'Aneurysm', 'Lymphopenia', 'Graft vs Host Disease', 'Lewy Body Disease', 'Synucleinopathies', 'Cerebrospinal Fluid Rhinorrhea', 'Camurati-Engelmann Syndrome', 'Osteoarthritis', 'Joint Diseases', 'Arthritis, Rheumatoid', 'Endocrine System Diseases', 'Myalgia', 'Silicosis', 'Pneumoconiosis', 'Heredodegenerative Disorders, Nervous System', 'Substance-Related Disorders', 'Hypoalphalipoproteinemias', 'Metabolic Diseases', 'Respiratory Hypersensitivity', 'Respiratory Insufficiency', 'Femoral Neck Fractures', 'Ossification, Heterotopic', 'Shoulder Fractures', 'Fracture Dislocation', 'Fabry Disease', 'Lysosomal Storage Diseases', 'Cardiomyopathies', 'Prostatic Neoplasms', 'Intellectual Disability', 'Hematoma, Subdural, Chronic', 'Pregnancy Complications, Infectious', 'Back Pain', 'Polyendocrinopathies, Autoimmune', 'Thyrotoxicosis', 'Hypolipoproteinemias', 'Voice Disorders', 'Lipid Metabolism Disorders', 'Carcinoma, Non-Small-Cell Lung', 'Diabetes Mellitus, Type 2', 'Arrhythmias, Cardiac', 'Huntington Disease', 'Musculoskeletal Diseases', 'Lung Injury', 'Glycogen Storage Disease Type II', 'Mitochondrial Encephalomyopathies', 'Acidosis, Lactic', 'Chemical and Drug Induced Liver Injury', 'Peroxisomal Disorders', 'Metabolism, Inborn Errors', 'Arbovirus Infections', 'Diverticular Diseases', 'Inflammatory Bowel Diseases', 'Bacterial Infections', 'Leukopenia', 'Coffin-Lowry Syndrome', 'Sleep Initiation and Maintenance Disorders', 'Brain Injuries, Traumatic', 'Ischemia', 'Epilepsy', 'Neurobehavioral Manifestations', 'Nerve Degeneration', 'Colitis, Ischemic', 'Colonic Polyps', 'Abdominal Pain', 'Gastrointestinal Hemorrhage', 'Guillain-Barre Syndrome', 'Ureteral Obstruction', 'Airway Obstruction', 'Ureteral Neoplasms', 'Shock, Septic', 'Spinal Cord Injuries', 'Urinary Bladder Diseases', 'Visceral Pain', 'Metabolic Syndrome', 'Cerebral Hemorrhage', 'Fanconi Anemia', 'Myotonic Dystrophy', 'Hypotrichosis', 'Tooth Loss', 'Lip Diseases', 'Mouth Diseases', 'Neuroma, Acoustic', 'Myoclonic Epilepsies, Progressive', 'Bone Neoplasms', 'Deafness', 'Tauopathies', 'Frontotemporal Lobar Degeneration', 'Fragile X Syndrome', 'Bundle-Branch Block', 'Dehydration', 'Hypoxia-Ischemia, Brain', 'Bacteriuria', 'Fetal Macrosomia', 'Polycystic Ovary Syndrome', 'Addison Disease', 'Adrenal Gland Neoplasms', 'Critical Illness', 'Tularemia', 'Klatskin Tumor', 'Biliary Dyskinesia', 'Cholangiocarcinoma', 'Gallbladder Neoplasms', 'Jaundice', 'Weight Loss', 'Sensation Disorders', 'Lymphoma, B-Cell', 'Liver Failure', 'Dyspnea', 'Pulmonary Embolism', 'Bone Diseases, Metabolic', 'Abnormalities, Drug-Induced', 'Brain Injury, Chronic', 'Lupus Erythematosus, Systemic', 'Vitamin B 6 Deficiency', 'Conjunctival Diseases', 'Cartilage Diseases', 'Keratitis, Dendritic', 'Microvascular Angina', 'Hypoglycemia', 'Diabetic Angiopathies', 'Sleep Deprivation', 'Fractures, Open', 'Ventricular Fibrillation', 'Peritoneal Neoplasms', 'Splenic Diseases', 'Edema', 'Cerebral Small Vessel Diseases', 'Amnesia', 'Sclerosis', 'Hepatitis B', 'Hepatitis, Viral, Human', 'Urolithiasis', 'Kidney Calculi', 'Diabetic Cardiomyopathies', 'Diabetes Mellitus, Type 1', 'Chagas Disease', 'Stomach Neoplasms', 'Soft Tissue Neoplasms', 'Peripheral Arterial Disease', 'Eyelid Neoplasms', 'Sebaceous Gland Neoplasms', 'Carcinoma, Basal Cell', 'Lymphoma', 'Carcinoma, Merkel Cell', 'Brain Damage, Chronic', 'Amyloidosis', 'Ketosis', 'Carcinogenesis', 'Colitis', 'Hemolytic-Uremic Syndrome', 'Anemia, Hemolytic', 'Thrombocytopenia', 'Hypertension, Pulmonary', 'Heart Block', 'Multiple Organ Failure', 'Labor Pain', 'Keratoderma, Palmoplantar', 'Sleep Paralysis', 'REM Sleep Behavior Disorder', 'Restless Legs Syndrome', 'Lymphedema', 'Cardiovascular Abnormalities', 'Calcinosis', 'Constriction, Pathologic', 'Heart Failure, Systolic', 'Heterotaxy Syndrome', 'Asthenia', 'Neutropenia', 'Plaque, Atherosclerotic', 'Movement Disorders', 'Ageusia', 'Blood Loss, Surgical', 'Facial Pain', 'Chest Pain', 'Kyphosis', 'Agnosia', 'Status Epilepticus', 'Trigeminal Neuralgia', 'Multiple Myeloma', 'Smoke Inhalation Injury', 'Graft Occlusion, Vascular', 'Pancreatitis, Graft', 'Brain Injuries', 'Dental Plaque', 'Aphasia', 'Supranuclear Palsy, Progressive', 'Retinal Degeneration', 'Sinusitis', 'Pneumococcal Infections', 'Aging, Premature', 'Aneuploidy', 'Somatosensory Disorders', 'Osteonecrosis', 'Neurogenic Inflammation', 'Vascular System Injuries', 'Jaw, Edentulous', 'Lung Diseases, Obstructive', 'Angina Pectoris', 'Hand-Arm Vibration Syndrome', 'Hypocalcemia', 'Hepatitis, Autoimmune', 'Liver Cirrhosis, Biliary', 'Cholangitis, Sclerosing', 'Radiation Pneumonitis', 'Malaria', 'Liver Cirrhosis', 'Anophthalmos', 'Nephritis, Interstitial', 'Gastrointestinal Diseases', 'Gastritis', 'Stomach Ulcer', 'Invasive Fungal Infections', 'Bacteremia', 'Dysbiosis', 'Dyskinesia, Drug-Induced', 'Kartagener Syndrome', 'Epilepsies, Partial', 'Drug Resistant Epilepsy', 'Glucose Intolerance', 'DiGeorge Syndrome', 'Leukoencephalopathies', 'Progeria', 'Skin Abnormalities', 'Coronavirus Infections', 'Proteostasis Deficiencies', 'Infertility, Male', 'Aortic Valve Stenosis', 'Thrombosis', 'Blood Coagulation Disorders', 'Vision, Low', 'Prostatic Hyperplasia', 'Chronic Pain', 'Macular Degeneration', 'Choroidal Neovascularization', 'Retinal Neoplasms', 'Tuberculosis', 'Glucose Metabolism Disorders', 'Dyscalculia', 'Cardio-Renal Syndrome', 'AIDS-Related Complex', 'Postoperative Cognitive Complications', 'Cardiac Complexes, Premature', 'Thrombophilia', 'Heart Rupture', 'Tinnitus', 'Sleep Disorders, Circadian Rhythm', 'Long QT Syndrome', 'Hepatitis B, Chronic', 'Hearing Loss, Central', 'Papilledema', 'Hearing Loss, Sudden', 'Necrosis', 'Migraine Disorders', 'Nephrosis, Lipoid', 'Confusion', 'Glomerulonephritis', 'Cleidocranial Dysplasia', 'Klebsiella Infections', 'Paraplegia', 'Crohn Disease', 'Growth Disorders', 'Sex Cord-Gonadal Stromal Tumors', 'Venous Thromboembolism', 'Osteosarcoma', 'Sarcoma', 'Thoracic Outlet Syndrome', 'Epilepsy, Absence', 'Sick Sinus Syndrome', 'Neoplasms, Experimental', 'Arteriosclerosis', 'Small Cell Lung Carcinoma', 'Carcinoma, Small Cell', 'Thyroid Neoplasms', 'Thyroiditis, Autoimmune', 'Intervertebral Disc Degeneration', 'Tongue, Fissured', 'Hernia', 'Werner Syndrome', 'Hepatitis E', 'Waterborne Diseases', 'Headache', 'Diurnal Enuresis', 'Postoperative Hemorrhage', 'Phenylketonurias', 'Pancreatic Neoplasms', 'Sleep Apnea, Obstructive', 'Cardiomyopathy, Dilated', 'Burning Mouth Syndrome', 'Staphylococcal Infections', 'Communication Disorders', 'Cold Injury', 'Xanthomatosis, Cerebrotendinous', 'Primary Ovarian Insufficiency', 'Migraine without Aura', 'Tachypnea', 'Ankle Injuries', 'Peripheral Nervous System Diseases', 'Fistula', 'Acute Pain', 'Gait Ataxia', 'Deglutition Disorders', 'Hypercholesterolemia', 'Alcoholism', 'Gangliosidosis, GM1', 'Cervical Intraepithelial Neoplasia', 'Carcinoma, Pancreatic Ductal', 'Blister', 'Serotonin Syndrome', 'Reflex, Abnormal', 'Fatty Liver', 'Urologic Neoplasms', 'Testicular Neoplasms', 'Pelvic Floor Disorders', 'Fanconi Syndrome', 'Myopathy, Central Core', 'Brain Ischemia', 'Severe Acute Respiratory Syndrome', 'Conjunctivitis, Acute Hemorrhagic', 'Cystitis', 'Urinary Bladder, Overactive', 'Cystitis, Interstitial', 'Panniculitis', 'Pancreatic Diseases', 'Pancreatitis', 'Erythema Nodosum', 'Whooping Cough', 'Distal Myopathies', 'Pelger-Huet Anomaly', 'Cholecystitis, Acute', 'Gangrene', 'Intraoperative Awareness', 'Paralysis', 'Bites and Stings', 'Uterine Cervicitis', 'Spinal Stenosis', 'Polyps', 'Ossification of Posterior Longitudinal Ligament', 'Angiodysplasia', 'von Willebrand Diseases', 'Pleural Effusion', 'Granuloma', 'Pleural Effusion, Malignant', 'Hyperparathyroidism', 'Mandibular Nerve Injuries', 'Adrenocortical Hyperfunction', 'Nephrotic Syndrome', 'Proteinuria', 'Carotid Artery Diseases', 'Hypothalamic Diseases', 'Tooth Diseases', 'Non-alcoholic Fatty Liver Disease', 'Sjogren-Larsson Syndrome', 'Hemophilia A', 'Blood Coagulation Disorders, Inherited', 'Hair Diseases', 'Hemorrhagic Disorders', 'Atrial Remodeling', 'Hyperalgesia', 'Short Bowel Syndrome', 'Tetany', 'Urinary Retention', 'Hirschsprung Disease', 'Peripheral Vascular Diseases', 'Carcinoma in Situ', 'Neoplasms, Cystic, Mucinous, and Serous', 'Myocarditis', 'Rheumatic Diseases', 'Corneal Diseases', 'Uterine Inertia', 'Hantavirus Pulmonary Syndrome', 'Limb Deformities, Congenital', 'Lower Extremity Deformities, Congenital', 'Hip Dislocation, Congenital', 'Fungemia', 'Invasive Pulmonary Aspergillosis', 'Hereditary Central Nervous System Demyelinating Diseases', 'Perceptual Disorders', 'Polyneuropathies', 'Vertigo', 'Nystagmus, Pathologic', 'Wasting Syndrome', 'Pneumonia, Aspiration', 'Head and Neck Neoplasms', 'Hydrocephalus', 'Tendinopathy', 'Collagen Diseases', 'Pneumothorax', 'Homocystinuria', 'Hyperlipoproteinemia Type II', 'Muscle Hypotonia', 'Albuminuria', 'Fractures, Compression', 'Tuberculosis, Multidrug-Resistant', 'Cholelithiasis', 'Cholecystitis', 'Lithiasis', 'Unconsciousness', 'Malformations of Cortical Development', 'Depression, Postpartum', 'Hepatic Veno-Occlusive Disease', 'Blood Platelet Disorders', 'Arthritis, Juvenile', 'Pharyngeal Diseases', 'Pleurisy', 'Disseminated Intravascular Coagulation', 'Cytomegalovirus Infections', 'Malocclusion', 'Meningococcal Infections', 'Dermatofibrosarcoma', 'Myoclonus', 'Anorexia', 'Disorders of Excessive Somnolence', 'Weight Gain', 'Nocturia', 'Psoriasis', 'Dermatitis, Atopic', 'Hypothyroidism', 'Digestive System Neoplasms', 'Arthralgia', 'Ventricular Dysfunction', 'Placenta Diseases', 'Hypereosinophilic Syndrome', 'Intraabdominal Infections', 'Retinal Diseases', 'Encephalitis', 'CHARGE Syndrome', 'Encephalitis, California', 'Kearns-Sayre Syndrome', 'Neurotoxicity Syndromes', 'Leishmaniasis, Visceral', 'Epilepsy, Temporal Lobe', 'Hepatitis C', 'Osteoma, Osteoid', 'Porphyria, Variegate', 'Surgical Wound Infection', 'Hyperkinesis', 'Keratosis, Actinic', 'Precancerous Conditions', 'Leukodystrophy, Globoid Cell', 'Aortic Aneurysm, Abdominal', 'Aortic Diseases', 'Dilatation, Pathologic', 'Astigmatism', 'Retinoschisis', 'Adenocarcinoma', 'Colonic Neoplasms', 'Hyponatremia', 'Hypogonadism', 'Eunuchism', 'Orchitis', 'Arrhythmogenic Right Ventricular Dysplasia', 'Tachycardia', 'Neuroacanthocytosis', 'Lipoma', 'Muscle Spasticity', 'Muscle Rigidity', 'Polymyalgia Rheumatica', 'Kidney Neoplasms', 'Erectile Dysfunction', 'Sexual Dysfunction, Physiological', 'Hernia, Inguinal', 'Gonorrhea', 'Pelvic Inflammatory Disease', 'Hyperemia', 'Motor Neuron Disease', 'Toothache', 'Pruritus', 'Exanthema', 'Common Variable Immunodeficiency', 'Parkinsonian Disorders', 'Hypokinesia', 'Stomatognathic Diseases', 'Cryptosporidiosis', 'Drug Overdose', 'Basal Ganglia Diseases', 'Choriocarcinoma', 'Blind Loop Syndrome', 'Gingival Overgrowth', 'Synovitis', 'Dystonia', 'Lymphatic Metastasis', 'Breast Neoplasms, Male', 'Myelitis', 'Polycythemia', 'Hematologic Diseases', 'Respiratory Syncytial Virus Infections', 'Hyperhomocysteinemia', 'Brain Diseases, Metabolic', 'Fetal Alcohol Spectrum Disorders', 'Cachexia', 'Leukemia, Lymphocytic, Chronic, B-Cell', 'Learning Disabilities', 'Varicose Ulcer', 'Gastroenteritis', 'Postoperative Nausea and Vomiting', 'Endometrial Neoplasms', 'Ankle Fractures', 'Pulmonary Atresia', 'Latent Tuberculosis', 'Tuberculosis, Meningeal', 'Lymphoma, Mantle-Cell', 'Dermatitis, Seborrheic', 'Thyroid Diseases', 'Craniofacial Abnormalities', 'Central Nervous System Neoplasms', 'Spinal Dysraphism', 'Stomach Volvulus', 'Facial Injuries', 'Maxillofacial Injuries', 'Acidosis', 'Hypertriglyceridemia', 'Meningitis, Aseptic', 'Rubella', 'Choroideremia', 'Overbite', 'Familial Mediterranean Fever', 'Pyelonephritis', 'Muscle Cramp', 'Oculocerebrorenal Syndrome', 'Tooth, Impacted', 'Congenital Hyperinsulinism', 'Insulin Resistance', 'Olfaction Disorders', 'Tibial Neuropathy', 'Tibial Fractures', 'Neoplastic Syndromes, Hereditary', 'Trauma, Nervous System', 'Hereditary Angioedema Type III', 'Adenomatous Polyps', 'Breakthrough Pain', 'Behcet Syndrome', 'Hashimoto Disease', 'Mesenteric Vascular Occlusion', 'Glioma', 'Endometriosis', 'Prostatitis', 'Optic Nerve Neoplasms', 'Glomus Tumor', 'Subarachnoid Hemorrhage', 'Adenoma', 'Cardiotoxicity', 'Cumulative Trauma Disorders', 'Granuloma, Plasma Cell', 'Hip Dislocation', 'Nausea', 'Obesity, Maternal', 'Esotropia', 'Strabismus', 'AIDS Arteritis, Central Nervous System', 'Esophageal Motility Disorders', 'Femoral Neuropathy', 'Somnambulism', 'Pseudarthrosis', 'Anaphylaxis', 'Cheilitis', 'Fibroma', 'Opportunistic Infections', 'Foot Ulcer', 'Thyroid Cancer, Papillary', 'Thyroid Carcinoma, Anaplastic', 'Muscular Dystrophies', 'Malabsorption Syndromes', 'Anemia, Megaloblastic', 'Eclampsia', 'Denys-Drash Syndrome', 'Hyperuricemia', 'Tachycardia, Ventricular', 'Flushing', 'Esophageal Squamous Cell Carcinoma', 'Intermittent Claudication', 'Nephrolithiasis', 'Crystal Arthropathies', 'Nematode Infections', 'Skin Ulcer', 'Cockayne Syndrome', 'Osteochondritis', 'Xeroderma Pigmentosum', 'Nail-Patella Syndrome', 'Glaucoma, Open-Angle', 'Ascites', 'Esophageal and Gastric Varices', 'Cholangitis', 'Hypertriglyceridemic Waist', 'Adenocarcinoma of Lung', 'Hyperplasia', 'Malformations of Cortical Development, Group I', 'Neuroendocrine Tumors', 'Carcinoma', 'Iatrogenic Disease', 'Osteolysis', 'Amniotic Band Syndrome', 'Glioblastoma', 'Neural Tube Defects', 'Disease Susceptibility', 'Urinary Tract Infections', 'Eye Infections, Fungal', 'Fractures, Spontaneous', 'Rheumatic Fever', 'Meningeal Neoplasms', 'Melkersson-Rosenthal Syndrome', 'Gastroparesis', 'Cerebral Palsy', 'Lactation Disorders', 'Facial Dermatoses', 'Microcephaly', 'Hypoadrenocorticism, Familial', 'Leg Ulcer', 'Insulinoma', 'Papillomavirus Infections', 'Meniere Disease', 'Orthostatic Intolerance', 'Signs and Symptoms, Digestive', 'Vitreous Hemorrhage', 'Dysplastic Nevus Syndrome', 'Lipodystrophy', 'Cardiac Output, High', 'Sleepiness', 'Pelizaeus-Merzbacher Disease', 'Consciousness Disorders', 'Mobility Limitation', 'Tooth Attrition', 'Hyperphosphatemia', 'Ear Diseases', 'Death, Sudden', 'Gait Disorders, Neurologic', 'Sphingolipidoses', 'Gliosis', 'Migraine with Aura', 'Fecal Incontinence', 'Adrenoleukodystrophy', 'Liver Diseases, Alcoholic', 'Occupational Stress', 'Cancer Pain', 'Contracture', 'End Stage Liver Disease', 'Lichen Sclerosus et Atrophicus', 'Diabetic Foot', 'Dysgeusia', 'Bone Malalignment', 'Meningitis', 'Chromosome Aberrations', 'Lichenoid Eruptions', 'Tooth Erosion', 'Shy-Drager Syndrome', 'Myotonia', 'Niemann-Pick Disease, Type A', 'Hemoglobinopathies', 'Hematoma, Subdural', 'Azoospermia', 'Ocular Motility Disorders', 'Lymphohistiocytosis, Hemophagocytic', 'Pancytopenia', 'Nervous System Malformations', 'Uterine Diseases', 'Mucositis', 'Myeloproliferative Disorders', 'Multiple Chronic Conditions', 'Embolism, Fat', 'Hypopituitarism', 'Vulvovaginitis', 'Porencephaly', 'Intraoperative Complications', 'Joint Dislocations', 'Peptic Ulcer', 'Common Cold', 'Tooth Injuries', 'Machado-Joseph Disease', 'Dysarthria', 'Oculomotor Nerve Diseases', 'Sertoli Cell-Only Syndrome', 'Colorectal Neoplasms, Hereditary Nonpolyposis', 'Foreign Bodies', 'Mental Fatigue', 'Alveolar Bone Loss', 'Bone Resorption', 'Gingivitis', 'Upper Extremity Deformities, Congenital', 'Pulmonary Alveolar Proteinosis', 'Hyperbilirubinemia', 'Pain Insensitivity, Congenital', 'Hereditary Breast and Ovarian Cancer Syndrome', 'Sarcoma, Kaposi', 'Kidney Tubular Necrosis, Acute', 'Bilateral Vestibulopathy', 'Benign Paroxysmal Positional Vertigo', 'Choroiditis', 'Ebstein Anomaly', 'Leukemia, Myelomonocytic, Chronic', 'Hemorrhagic Fever with Renal Syndrome', 'Meningitis, Bacterial', 'Hypesthesia', 'Facial Paralysis', 'Postoperative Complications', 'Hernias, Diaphragmatic, Congenital', 'Bronchial Spasm', 'Multiple Trauma', 'Dentin Sensitivity', 'Rhinitis, Allergic', 'Lissencephaly', 'Nutrition Disorders', 'Hemostatic Disorders', 'Pulmonary Aspergillosis', 'Carcinoma, Acinar Cell', 'Reperfusion Injury', 'DNA Repair-Deficiency Disorders', 'Congenital Abnormalities', 'Bone Marrow Failure Disorders', 'Ataxia Telangiectasia', 'Thoracic Injuries', 'Congenital, Hereditary, and Neonatal Diseases and Abnormalities', 'Arteritis', 'Lafora Disease', 'Ependymoma', 'Atrioventricular Block', 'Acromegaly', 'Pituitary Neoplasms', 'Hand Injuries', 'Crush Injuries', 'Cerebral Intraventricular Hemorrhage', 'Arteriovenous Malformations', 'Central Nervous System Vascular Malformations', 'Cross Infection', 'Obstetric Labor, Premature', 'Vestibular Diseases', 'Fetal Diseases', 'Inert Gas Narcosis', 'Foodborne Diseases', 'Takotsubo Cardiomyopathy', 'Ventricular Remodeling', 'Anemia, Sickle Cell', 'Hemolysis', 'Gout', 'Adenocarcinoma, Mucinous', 'Neoplasms, Multiple Primary', 'Poroma', 'Papilloma', 'Arthritis, Psoriatic', 'Torsades de Pointes', 'Shock', 'Hypoalbuminemia', 'Vitamin K Deficiency', 'Anhedonia', 'Mutism', 'Astrocytoma', 'Oligodendroglioma', 'Trismus', 'Hyperkeratosis, Epidermolytic', 'Arteriolosclerosis', 'Cryoglobulinemia', 'Leukocytosis', 'Pemphigus, Benign Familial', 'Pyruvate Carboxylase Deficiency Disease', 'Coagulation Protein Disorders', 'Factor XIII Deficiency', 'Bronchopulmonary Dysplasia', 'Respiratory Sounds', 'Exocrine Pancreatic Insufficiency', 'Syncope, Vasovagal', 'Pediatric Obesity', 'Neonatal Abstinence Syndrome', 'Enterovirus Infections', 'Pseudoxanthoma Elasticum', 'Thyroid Nodule', 'Neuralgia', 'Hepatolenticular Degeneration', 'Hemangioma, Cavernous, Central Nervous System', 'Embryo Loss', 'Retinal Detachment', 'Ecchymosis', 'Enthesopathy', 'Epilepsy, Tonic-Clonic', 'Embolism', 'Shock, Hemorrhagic', 'Jaw Diseases', 'White Coat Hypertension', 'Mucopolysaccharidosis III', 'Nephrosclerosis', 'Chronobiology Disorders', 'Pseudomonas Infections', 'Pneumoperitoneum', 'Coronaviridae Infections', 'Eosinophilic Esophagitis', 'Hyperacusis', 'Lupus Nephritis', 'Intracranial Aneurysm', 'Urogenital Abnormalities', 'Malaria, Cerebral', 'Hyperpigmentation', 'Demyelinating Diseases', 'Bankart Lesions', 'Esophageal Neoplasms', 'Intracranial Arteriosclerosis', 'Stroke, Lacunar', 'Alcoholic Neuropathy', 'Cluster Headache', 'Emphysema', 'Dental Caries', 'Infertility', 'Brain Diseases, Metabolic, Inborn', 'Lordosis', 'Fat Necrosis', 'Urinary Incontinence, Stress', 'Vulvar Neoplasms', 'Basal Ganglia Cerebrovascular Disease', 'Radiculopathy', 'Neoplasm Invasiveness', 'Extranodal Extension', 'Hodgkin Disease', 'Lymphoma, Follicular', 'Coronary Stenosis', 'Diplopia', 'Compassion Fatigue', 'Brain Stem Neoplasms', 'Diverticulitis, Colonic', 'Diverticulitis', 'Dysuria', 'Dyspareunia', 'Lymphoproliferative Disorders', 'Hypothermia', 'Brain Edema', 'Color Vision Defects', 'Hypertrophy, Left Ventricular', 'Prostatic Diseases', 'Taste Disorders', 'Biliary Tract Neoplasms', 'Poisoning', 'Breech Presentation', 'Spinal Injuries', 'Prader-Willi Syndrome', 'Cutaneous Fistula', 'Uremia', 'Apnea', 'Radiation Injuries', 'Rhinitis', 'Hypertension, Renal', 'Schistosomiasis', 'Opisthorchiasis', 'Muscular Atrophy, Spinal', 'Nervous System Autoimmune Disease, Experimental', 'Colitis, Ulcerative', 'Pulmonary Arterial Hypertension', 'Hemangiosarcoma', 'Pleural Diseases', 'Gerstmann Syndrome', 'Squamous Cell Carcinoma of Head and Neck', 'Acute Disease', 'Dyskeratosis Congenita', 'Hemochromatosis', 'Tetralogy of Fallot', 'Glioma, Subependymal', 'Carpal Tunnel Syndrome', 'Mitral Valve Stenosis', 'Neoplasms, Neuroepithelial', 'Choroid Diseases', 'Deaf-Blind Disorders', 'Coxa Magna', 'Diabetic Neuropathies', 'Zoonoses', 'Tonsillar Neoplasms', 'Streptococcal Infections', 'Salter-Harris Fractures', 'Angina, Stable', 'Ventricular Dysfunction, Right', 'AIDS Dementia Complex', 'Factor XII Deficiency', 'Hereditary Autoinflammatory Diseases', 'Macrophage Activation Syndrome', 'Osteoarthritis, Hip', 'Liver Cirrhosis, Alcoholic', 'Retinoblastoma', 'Pulmonary Fibrosis', 'Appendicitis', 'Catastrophic Illness', 'Accidental Injuries', 'Retinal Vein Occlusion', 'Pulmonary Valve Insufficiency', 'Aspartylglucosaminuria', 'Pericarditis', 'Cerebrovascular Trauma', 'Williams Syndrome', 'Paraneoplastic Syndromes', 'Wounds, Nonpenetrating', 'Obstetric Labor Complications', 'Primary Dysautonomias', 'Pregnancy, Prolonged', 'Hyperinsulinism', 'Herpes Zoster', 'Adrenocortical Carcinoma', 'Anastomotic Leak', 'Neuroleptic Malignant Syndrome', 'Urinary Bladder Neck Obstruction', 'Tuberculosis, Spinal', 'Tuberculosis, Pulmonary', 'White Dot Syndromes', 'Thinness', 'Mycoses', 'Demyelinating Autoimmune Diseases, CNS', 'Hepatopulmonary Syndrome', 'Acne Vulgaris', 'Intracranial Arterial Diseases', 'Spinocerebellar Ataxias', 'Tics', 'Congenital Hypothyroidism', 'Ectodermal Dysplasia', 'Patellar Dislocation', 'Lupus Vasculitis, Central Nervous System', 'Biliary Tract Diseases', 'Scoliosis', 'Hematoma, Epidural, Spinal', 'Spinal Fractures', 'Polycystic Kidney Diseases', 'Autoimmune Lymphoproliferative Syndrome', 'Lens Diseases', 'Lymphatic Diseases', 'Vitiligo', 'Urinary Bladder, Neurogenic', 'Myoma', 'Leiomyoma', 'Gingival Recession', 'Ventricular Dysfunction, Left', 'Eye Abnormalities', 'Leg Injuries', 'Plant Poisoning', 'Masked Hypertension', 'Aicardi Syndrome', 'Respiration Disorders', 'Helicobacter Infections', 'Nephritis', 'Nephrosis', 'Bone Marrow Diseases', 'Obesity, Metabolically Benign', 'Aphasia, Wernicke', 'Turner Syndrome', 'Fatigue Syndrome, Chronic', 'Mesothelioma', 'Shock, Cardiogenic', 'Synostosis', 'Phosphorus Metabolism Disorders', 'Congenital Bone Marrow Failure Syndromes', 'Anemia, Aplastic', 'Hypernatremia', 'Hematoma, Subdural, Acute', 'Soft Tissue Injuries', 'Retinitis', 'Hyperkalemia', 'Scotoma', 'Amenorrhea', 'Spinal Diseases', 'Mouth Neoplasms', 'Ventricular Outflow Obstruction', 'Cushing Syndrome', 'Leigh Disease', 'Candidemia', 'Glucosephosphate Dehydrogenase Deficiency', 'Hepatomegaly', 'Primary Myelofibrosis', 'Carotid Stenosis', 'Leukemia, Myelogenous, Chronic, BCR-ABL Positive', 'Heart Defects, Congenital', 'Keratosis, Seborrheic', 'Acanthosis Nigricans', 'Aortic Aneurysm', 'Iliac Aneurysm', 'Corneal Dystrophies, Hereditary', 'Vaginitis', 'Dyspepsia', 'Capillary Leak Syndrome', 'Paraproteinemias', 'Thymus Neoplasms', 'Glomerulosclerosis, Focal Segmental', 'Quadriplegia', 'Pulmonary Heart Disease', 'Tuberous Sclerosis', 'Eczema', 'Peri-Implantitis', 'Parasitic Diseases', 'Mesial Movement of Teeth', 'Brugada Syndrome', 'Stargardt Disease', 'Hepatic Encephalopathy', 'Spinal Cord Diseases', 'Microtrauma, Physical', 'Liver Failure, Acute', 'Lethargy', 'Rhabdomyolysis', 'Menstruation Disturbances', 'Tourette Syndrome', 'Splenomegaly', 'Fractures, Malunited', 'Cholestasis, Extrahepatic', 'Retinal Neovascularization', 'Neurosyphilis', 'Abducens Nerve Diseases', 'Parasitemia', 'Milk Hypersensitivity', 'Toxoplasmosis', 'Hyperhidrosis', 'Prodromal Symptoms', 'Miosis', 'Premenstrual Dysphoric Disorder', 'Dwarfism, Pituitary', 'X-Linked Combined Immunodeficiency Diseases', 'Urinary Incontinence, Urge', 'Vitamin E Deficiency', 'Microvascular Rarefaction', 'Hip Injuries', 'Fallopian Tube Diseases', 'Dental Leakage', 'Gallstones', 'Chondrocalcinosis', 'Chronic Traumatic Encephalopathy', 'Malaria, Vivax', 'Fractures, Stress', 'Lip Neoplasms', 'Aspergillosis, Allergic Bronchopulmonary', 'Scabies', 'Occupational Diseases', 'Ventricular Premature Complexes', 'Hemorrhoids', 'Lens Subluxation', 'Hemorrhagic Fever, Ebola', 'Mandibulofacial Dysostosis', 'Cerebellar Diseases', 'Cholesteatoma', 'Neuroaxonal Dystrophies', 'Language Disorders', 'Skin Diseases, Vesiculobullous', 'Skin Diseases, Eczematous', 'Sciatic Neuropathy', 'Tongue Diseases', 'Thalamic Diseases', 'Neoplasms, Nerve Tissue', 'Cholestasis', 'Anemia, Iron-Deficiency', 'Hypercalcemia', 'Hypervitaminosis A', 'Liver Neoplasms, Experimental', 'Nocturnal Enuresis', 'Pulmonary Edema', 'Prostatic Intraepithelial Neoplasia', 'Hamartoma Syndrome, Multiple', 'Parasomnias', 'Hyperthyroidism', 'Stillbirth', 'Tenosynovitis', 'Bursitis', 'Headache Disorders', 'Systemic Inflammatory Response Syndrome', 'Dysphonia', 'Precursor Cell Lymphoblastic Leukemia-Lymphoma', 'Aneurysm, Ruptured', 'Protein S Deficiency', 'Epilepsies, Myoclonic', 'Myasthenia Gravis', 'Spondylolysis', 'Tibial Meniscus Injuries', 'Rabies', 'Esophageal Achalasia', 'Onycholysis', 'Pulmonary Emphysema', 'Gastroesophageal Reflux', 'Parathyroid Neoplasms', 'Hyperparathyroidism, Primary', 'Multiple Endocrine Neoplasia', 'Clonorchiasis', 'Tachycardia, Atrioventricular Nodal Reentry', 'Ovarian Hyperstimulation Syndrome', 'Scleroderma, Systemic', 'Dermatomyositis', 'Cardiovascular Infections', 'von Willebrand Disease, Type 1', 'Leprosy, Tuberculoid', 'Neuronal Ceroid-Lipofuscinoses', 'Porphyria, Erythropoietic', 'Intra-Articular Fractures', 'Intestinal Diseases', 'Soft Tissue Infections', 'Fasciitis, Necrotizing', 'Substance Withdrawal Syndrome', 'Osteomyelitis', 'Acro-Osteolysis', 'Asymptomatic Infections', 'Epidermal Cyst', 'Striatonigral Degeneration', 'Urination Disorders', 'Malaria, Falciparum', 'Hepatitis D', 'Cellulitis', 'Bronchitis', 'Intracranial Embolism', 'Central Serous Chorioretinopathy', 'Bisphosphonate-Associated Osteonecrosis of the Jaw', 'Arthritis, Infectious', 'Miliaria', 'Intestinal Pseudo-Obstruction', 'Thrombophlebitis', 'Carcinoma, Adenosquamous', 'Reflex Sympathetic Dystrophy', 'Cerebral Arterial Diseases', 'Hypophysitis', 'Waldenstrom Macroglobulinemia', 'Atrial Flutter', 'Medulloblastoma', 'Poliomyelitis', 'Fibromuscular Dysplasia', 'Folic Acid Deficiency', 'Renal Tubular Transport, Inborn Errors', 'Foot Deformities', 'Metatarsus Varus', 'Hallux Valgus', 'Hypokalemia', 'TDP-43 Proteinopathies', 'Leprosy', 'Magnesium Deficiency', 'Anemia, Hemolytic, Autoimmune', 'Anemia, Macrocytic', 'Sinus Thrombosis, Intracranial', 'Varicella Zoster Virus Infection', 'Hallux Rigidus', 'Telangiectasis', 'LEOPARD Syndrome', 'Inappropriate ADH Syndrome', 'Alcoholic Intoxication', 'Gitelman Syndrome', 'Hemophilia B', 'Pelvic Organ Prolapse', 'Diabetes, Gestational', 'Prion Diseases', 'Dental Pulp Necrosis', 'Sotos Syndrome', 'Opioid-Related Disorders', 'Arteriovenous Fistula', 'Narcolepsy', 'Lymphadenitis', 'Urticaria', 'Pelvic Pain', 'Menorrhagia', 'Flatulence', 'Rib Fractures', 'Agammaglobulinemia', 'Diabetic Ketoacidosis', 'Cubital Tunnel Syndrome', 'Rothmund-Thomson Syndrome', 'Cranial Nerve Diseases', 'Speech Disorders', 'Nerve Compression Syndromes', 'Spinal Osteophytosis', 'Vitreous Detachment', 'Dengue', 'Testicular Diseases', 'Heart Septal Defects, Atrial', 'Retroperitoneal Fibrosis', 'Aortitis', "Mikulicz' Disease", 'Eosinophilia', 'Puberty, Delayed', 'Wallerian Degeneration', 'Mediastinal Cyst', 'Retinal Arterial Macroaneurysm', 'Osteoarthritis, Knee', 'Glomerulonephritis, Membranous', 'Purpura Fulminans', 'Chromosomal Instability', 'Conjunctivitis', 'Cafe-au-Lait Spots', 'Small Fiber Neuropathy', 'Coronary Thrombosis', 'Jaw Abnormalities', 'Alkaptonuria', 'Colonic Diseases', 'Clostridium Infections', 'Neoplasms, Second Primary', 'Encephalomyelitis, Autoimmune, Experimental', 'Fibromyalgia', 'Bell Palsy', 'Earache', 'Teratozoospermia', 'Vasculitis, Central Nervous System', 'Catheter-Related Infections', 'Pars Planitis', 'Dermatitis, Contact', 'Dermatitis', 'Wiskott-Aldrich Syndrome', 'Disease Models, Animal', 'Hypoparathyroidism', 'Agranulocytosis', 'Carcinoma, Ovarian Epithelial', 'Conjunctivitis, Allergic', 'Gingival Hemorrhage', 'Pre-Eclampsia', 'Short Rib-Polydactyly Syndrome', 'Myiasis', 'Catatonia', 'Craniosynostoses', 'Lymphocytosis', 'Canavan Disease', 'Peroneal Neuropathies', 'Leukoaraiosis', 'Athletic Injuries', 'Myositis', 'Polymyositis', 'Hyper-IgM Immunodeficiency Syndrome', 'Paratuberculosis', 'Sphincter of Oddi Dysfunction', 'Sleep-Wake Transition Disorders', 'Stiff-Person Syndrome', 'Disease Progression', 'Endomyocardial Fibrosis', 'Trisomy', 'Pupil Disorders', 'Retinal Artery Occlusion', 'Eyelid Diseases', 'Peritonitis, Tuberculous', 'Cell Transformation, Viral', 'Uterine Cervical Neoplasms', 'Contusions', 'Gastrointestinal Stromal Tumors', 'Amyloidosis, Familial', 'Duodenal Diseases', 'Gastric Outlet Obstruction', 'Retinal Necrosis Syndrome, Acute', 'Osteoarthropathy, Primary Hypertrophic', 'Orbital Neoplasms', 'Carcinoma, Adenoid Cystic', 'Solitary Fibrous Tumors', 'Leukemia, Promyelocytic, Acute', 'Status Asthmaticus', 'Onychomycosis', 'Tinea Capitis', 'Hemiplegia', 'Thoracic Diseases', 'Angina, Unstable', 'Travel-Related Illness', 'Irritable Bowel Syndrome', 'Celiac Disease', 'Spinal Cord Compression', 'Labyrinth Diseases', 'Encephalomyelitis, Acute Disseminated', 'Discrete Subaortic Stenosis', 'Sexual Infantilism', 'Graves Disease', 'Hepatic Insufficiency', 'Ear Neoplasms', 'Essential Tremor', 'Dermatitis, Exfoliative', 'Double Outlet Right Ventricle', 'Anterior Compartment Syndrome', 'Tendon Injuries', 'Respiratory Paralysis', 'Graves Ophthalmopathy', 'Paralysis, Hyperkalemic Periodic', 'Carcinoma, Mucoepidermoid', 'Enteritis', 'Dihydropyrimidine Dehydrogenase Deficiency', 'Optic Nerve Diseases', "Colles' Fracture", 'Vestibular Neuronitis', 'Nervous System Neoplasms', 'Vascular Remodeling', 'Protein-Energy Malnutrition', 'Adrenal Cortex Neoplasms', 'Pheochromocytoma', 'Urethral Neoplasms', 'Hemifacial Spasm', 'Hematuria', 'Cell Transformation, Neoplastic', 'Urologic Diseases', 'Creutzfeldt-Jakob Syndrome', 'Budd-Chiari Syndrome', 'Diffuse Neurofibrillary Tangles with Calcification', 'Meningitis, Pneumococcal', 'Ventricular Septal Rupture', 'Pulmonary Valve Stenosis', 'Compartment Syndromes', 'Tooth Avulsion', 'Myotoxicity', 'Cri-du-Chat Syndrome', 'Calculi', 'Vitreoretinopathy, Proliferative', 'Epidermodysplasia Verruciformis', 'Auditory Perceptual Disorders', 'Hydronephrosis', 'Bronchopneumonia', 'Intracranial Hemorrhage, Hypertensive', 'Cryopyrin-Associated Periodic Syndromes', 'Femur Head Necrosis', 'Rectal Neoplasms', 'Retinal Perforations', 'Diabetes Insipidus', 'Hypophosphatemia', 'Urogenital Neoplasms', 'Leishmaniasis', 'Arthritis, Experimental', 'Scleral Diseases', 'Virilism', 'Kidney Diseases, Cystic', 'Thrombocythemia, Essential', 'Encephalomyelitis', 'Optic Neuritis', 'Trichomonas Infections', 'Halitosis', 'Ciliopathies', 'Heat Stroke', 'Epilepsy, Frontal Lobe', 'Venous Insufficiency', 'Persistent Vegetative State', 'Korsakoff Syndrome', 'Polycythemia Vera', 'Gonadal Disorders', 'Spondylosis', 'Lysosomal Storage Diseases, Nervous System', 'Tic Disorders', 'Corneal Edema', 'Aneurysm, False', 'Thrombotic Microangiopathies', 'Purpura, Thrombotic Thrombocytopenic', 'Spasm', 'Central Cord Syndrome', 'Scrub Typhus', 'Arnold-Chiari Malformation', 'Cerebrospinal Fluid Leak', 'Tuberculoma', 'Bronchiolitis', 'Stenosis, Pulmonary Artery', 'Malocclusion, Angle Class II', 'Hyperandrogenism', 'Pulmonary Atelectasis', 'Leukoplakia', 'Neuroschistosomiasis', 'Herpesviridae Infections', 'Knee Injuries', 'West Nile Fever', 'Cleft Palate', 'Thyroid Hormone Resistance Syndrome', 'Epilepsy, Reflex', 'Congenitally Corrected Transposition of the Great Arteries', 'Gastritis, Atrophic', 'Hepatorenal Syndrome', 'Wilms Tumor', 'Schistosomiasis japonica', 'Hypopigmentation', 'Uveitis', 'Iridocyclitis', 'Uveomeningoencephalitic Syndrome', 'Uveitis, Anterior', 'Endophthalmitis', 'Protein-Losing Enteropathies', 'Keratitis', 'Drug Eruptions', 'Space Motion Sickness', "Fuchs' Endothelial Dystrophy", 'Leukoplakia, Hairy', 'Epstein-Barr Virus Infections', 'Melanosis', 'Dendritic Cell Sarcoma, Follicular', 'Lesch-Nyhan Syndrome', 'Hyperostosis, Diffuse Idiopathic Skeletal', 'Rotator Cuff Tear Arthropathy', 'Temporomandibular Joint Disorders', 'Babesiosis', 'Myopathies, Structural, Congenital', 'Osteoarthropathy, Secondary Hypertrophic', 'Achondroplasia', 'Perinephritis', 'Atrophic Vaginitis', 'Tachycardia, Supraventricular', 'Pick Disease of the Brain', 'Endotoxemia', 'Neuromyelitis Optica', 'Cleft Lip', 'Vipoma', 'Colitis, Lymphocytic', 'Colitis, Collagenous', 'Smooth Muscle Tumor', 'Epilepsy, Complex Partial', 'Otitis', 'Angioedema', 'Hypoxia, Brain', 'Diverticulum', 'Thalassemia', 'Anemia, Hemolytic, Congenital', 'Illusions', 'Pulpitis', 'Epidermolysis Bullosa Dystrophica', 'Facial Neuralgia', 'Occupational Injuries', 'Osteochondromatosis', 'Headache Disorders, Primary', 'Intracranial Thrombosis', 'Leukoencephalitis, Acute Hemorrhagic', 'Hyphema', 'Orbital Fractures', 'Erysipelas', 'Vaginal Neoplasms', 'Plummer-Vinson Syndrome', 'Putaminal Hemorrhage', 'Legg-Calve-Perthes Disease', 'Proctitis', 'Hemangioma', 'Osteopoikilosis', 'Hypercapnia', 'Postural Orthostatic Tachycardia Syndrome', 'Drug Hypersensitivity Syndrome', 'Hypovolemia', 'Hepatitis C, Chronic', 'Microsatellite Instability', 'Fibrous Dysplasia of Bone', 'Pyoderma Gangrenosum', 'Urea Cycle Disorders, Inborn', 'Ovarian Cysts', 'Mastocytosis, Cutaneous', 'Metaplasia', 'Postmortem Changes', 'Muscular Dystrophy, Emery-Dreifuss', 'Vestibulocochlear Nerve Injuries', 'Dermatitis Herpetiformis', 'Conjunctivitis, Bacterial', 'Iliotibial Band Syndrome', 'Pemphigoid, Bullous', 'Uterine Retroversion', 'Chronic Periodontitis', 'Radicular Cyst', 'Angioedemas, Hereditary', 'Langer-Giedion Syndrome', 'Hemoptysis', 'Muscle Hypertonia', 'Myofascial Pain Syndromes', 'Agraphia', 'Cystadenocarcinoma, Serous', 'alpha-Thalassemia', 'Priapism', 'Legionellosis', 'Periodontal Cyst', 'Urinary Bladder Calculi', 'Hyperoxia', 'Tooth Wear', 'Bruxism', 'Odontoma', 'Tooth Fractures', 'Ankyloglossia', 'Osteophyte', 'Jejunal Neoplasms', 'Gilbert Disease', 'Brachial Plexus Neuropathies', 'Ellis-Van Creveld Syndrome', 'Sacroiliitis', 'Arachnoid Cysts', 'Coronary Aneurysm', 'Mucocutaneous Lymph Node Syndrome', 'Back Injuries', 'Blepharoptosis', 'Amino Acid Metabolism, Inborn Errors', 'Candidiasis, Vulvovaginal', 'Candidiasis, Cutaneous', 'Endocrine Gland Neoplasms', 'Language Development Disorders', 'Myelitis, Transverse', 'Toxoplasmosis, Ocular', 'Encephalitis, Herpes Simplex', 'Trochlear Nerve Diseases', 'Dentin Dysplasia', 'Ulna Fractures', 'Ocular Hypotension', 'Multiple Pulmonary Nodules', 'Hernia, Hiatal', 'Mitochondrial Myopathies', 'Heat Exhaustion', 'Rosacea', 'Nose Diseases', 'Zika Virus Infection', 'Tick-Borne Diseases', 'Rickettsia Infections', 'Tick Infestations', 'Euthyroid Sick Syndromes', 'Polyarteritis Nodosa', 'Systemic Vasculitis', 'Infant, Premature, Diseases', 'Dystocia', 'Fetal Growth Retardation', 'Stomatitis', 'Leukoplakia, Oral', 'Kidney Cortex Necrosis', 'Motion Sickness', 'Vestibulocochlear Nerve Diseases', 'Blepharitis', 'von Willebrand Disease, Type 3', 'Lipodystrophy, Familial Partial', 'Noncommunicable Diseases', 'Siderosis', 'Facial Nerve Injuries', 'Salmonella Infections', 'Purpura', 'Ehlers-Danlos Syndrome', 'Coccidioidomycosis', 'Spondylitis, Ankylosing', 'Penile Induration', 'Bone Diseases, Developmental', 'Duodenal Neoplasms', 'Intestinal Neoplasms', 'Niemann-Pick Disease, Type C', 'Goiter', 'Glaucoma, Angle-Closure', 'Uveal Effusion Syndrome', 'Biliary Fistula', 'Monoclonal Gammopathy of Undetermined Significance', 'Multicystic Dysplastic Kidney', 'Intracranial Arteriovenous Malformations', 'Arrhythmia, Sinus', 'Immune Complex Diseases', 'Coxa Valga', 'Odontodysplasia', 'Odontogenic Tumors', 'Meningoencephalitis', 'Neoplastic Cells, Circulating', 'Tuberculosis, Osteoarticular', 'Amyloid Neuropathies', 'Hammer Toe Syndrome', 'Diverticulosis, Colonic', 'Radial Neuropathy', 'Intra-Abdominal Hypertension', 'Uterine Hemorrhage', 'Leukemia, B-Cell', 'Connective Tissue Diseases', 'Eye Infections', 'Cerebellar Ataxia', 'Cutis Laxa', 'Candidiasis', 'Coloboma', 'Central Nervous System Infections', 'Chickenpox', 'Lentigo', 'Abortion, Threatened', 'Friedreich Ataxia', 'Neoplasm, Residual', 'Lymphoma, T-Cell', 'Rhinitis, Allergic, Seasonal', 'Patellofemoral Pain Syndrome', 'Linear IgA Bullous Dermatosis', 'Retrograde Degeneration', 'Amelogenesis Imperfecta', 'Thyroiditis', 'Carcinoma, Skin Appendage', 'Infarction, Posterior Cerebral Artery', 'Endometritis', 'Overweight', 'Retinal Hemorrhage', 'Pneumocephalus', 'Embolism, Air', 'Pericardial Effusion', 'Anemia, Sideroblastic', 'Pancreatic Fistula', 'Amblyopia', 'Keloid', 'Myofibroma', 'Infratentorial Neoplasms', 'Bronchial Diseases', 'Pressure Ulcer', 'Myosarcoma', 'Eczema, Dyshidrotic', 'Wolfram Syndrome', 'Adrenal Hyperplasia, Congenital', 'Prosopagnosia', 'Aspergillosis', 'von Hippel-Lindau Disease', 'Sarcoma, Clear Cell', 'Heart Injuries', 'Diabetes Insipidus, Neurogenic', 'Fused Teeth', 'Myositis, Inclusion Body', 'Cytochrome-c Oxidase Deficiency', 'Diastema', 'Adenoma, Oxyphilic', 'Intestinal Fistula', 'Supratentorial Neoplasms', 'Coronary Vessel Anomalies', 'Radius Fractures', 'Essential Hypertension', 'Lecithin Cholesterol Acyltransferase Deficiency', 'Alagille Syndrome', 'Laryngismus', 'Facial Nerve Diseases', 'Brain Injuries, Diffuse', 'Cicatrix, Hypertrophic', 'Brief, Resolved, Unexplained Event', 'Vitamin A Deficiency', 'Onchocerciasis', 'Trachoma', 'Mastoiditis', 'Autonomic Nervous System Diseases', 'Neurilemmoma', 'Hallux Varus', 'Gingival Diseases', 'Pleural Neoplasms', 'Tracheal Diseases', 'Philadelphia Chromosome', 'Carcinoma, Ductal', 'Chikungunya Fever', 'Meibomian Gland Dysfunction', 'Endometrial Hyperplasia', 'Meningocele', 'Aortic Aneurysm, Thoracic', 'Pinealoma', 'Asbestosis', 'Rett Syndrome', 'Coronary Occlusion', 'Adenoma, Villous', 'Intestinal Atresia', 'Choledocholithiasis', 'Encephalitis, Tick-Borne', 'Parkinson Disease, Postencephalitic', 'Bulbar Palsy, Progressive', 'Coronary Restenosis', 'Desmoplastic Small Round Cell Tumor', 'Neuromuscular Junction Diseases', 'Carcinosarcoma', 'Gliosarcoma', 'Liposarcoma', 'Precursor T-Cell Lymphoblastic Leukemia-Lymphoma', 'Gaucher Disease', 'Pyuria', 'Primary Graft Dysfunction', 'Pathological Conditions, Signs and Symptoms', 'Coronary Vasospasm', 'Xanthomatosis', 'Dyskinesias', 'Endocarditis, Bacterial', 'CADASIL', 'Intestinal Obstruction', 'Heart Septal Defects, Ventricular', 'Foot Diseases', 'Intestinal Volvulus', 'Pityriasis Rubra Pilaris', 'Condylomata Acuminata', 'Lupus Erythematosus, Cutaneous', 'Hidradenitis Suppurativa', 'Folliculitis', 'Lymphoma, T-Cell, Cutaneous', 'Hidradenitis', 'Dermatitis, Phototoxic', 'Sinus Arrest, Cardiac', 'Fucosidosis', 'Optic Atrophy, Autosomal Dominant', 'Tension-Type Headache', 'Fractures, Avulsion', 'Iron Metabolism Disorders', 'Pancreatic Intraductal Neoplasms', 'Cerebrospinal Fluid Otorrhea', 'Leukemia, Lymphoid', 'Lymphoma, B-Cell, Marginal Zone', 'Asthenopia', 'Focal Epithelial Hyperplasia', 'Tobacco Use Disorder', 'Tachycardia, Sinus', 'Varicose Veins', 'Hemangioblastoma', 'Capsule Opacification', 'Churg-Strauss Syndrome', 'Stenosis, Pulmonary Vein', 'Alert Fatigue, Health Personnel', 'Hepatitis', 'Growth Hormone-Secreting Pituitary Adenoma', 'Chondrosarcoma', 'Pancreaticobiliary Maljunction', 'Hyperemesis Gravidarum', 'Rare Diseases', 'Craniopharyngioma', 'Facial Hemiatrophy', 'Ischemic Attack, Transient', 'Intestinal Polyposis', 'Paroxysmal Hemicrania', 'Horner Syndrome', 'Yang Deficiency', 'Encephalocele', 'Sweating Sickness', "Tietze's Syndrome", 'Periodontal Attachment Loss', 'Spontaneous Perforation', 'Salivary Gland Neoplasms', 'Nociceptive Pain', 'Blood Protein Disorders', 'Thrombocytosis', 'Exfoliation Syndrome', 'Heat Stress Disorders', 'Duodenal Obstruction', 'Optic Neuropathy, Ischemic', 'GATA2 Deficiency', 'Gerstmann-Straussler-Scheinker Disease', 'Mesenteric Ischemia', 'Peritonitis', 'Otitis Media', 'Liposarcoma, Myxoid', 'Spondylarthropathies', 'Tungiasis', 'Shoulder Impingement Syndrome', 'Pancreatitis, Acute Necrotizing', 'Mouth Breathing', 'Appendiceal Neoplasms', 'Genetic Diseases, X-Linked', 'Enterocolitis', 'Spinocerebellar Degenerations', 'Nocardia Infections', 'Equinus Deformity', 'AIDS-Associated Nephropathy', 'Intracranial Hemorrhage, Traumatic', 'Genomic Instability', 'Ureteral Diseases', 'Holoprosencephaly', 'Eye Pain', 'Encephalitis, Varicella Zoster', 'Seroma', 'Scleroderma, Localized', 'Rigor Mortis', 'Rotavirus Infections', 'Trisomy 18 Syndrome', 'Osteoarthritis, Spine', 'Shoulder Dislocation', 'Rotator Cuff Injuries', 'Methemoglobinemia', 'Brenner Tumor', 'Metrorrhagia', 'IgA Deficiency', 'Leiomyosarcoma', 'Peutz-Jeghers Syndrome', 'IgA Vasculitis', 'Nasal Obstruction', 'Anemia, Refractory', 'Pneumonia, Lipid', 'Cicatrix', 'Joint Instability', "Legionnaires' Disease", 'Conjunctival Neoplasms', 'Familial Primary Pulmonary Hypertension', 'Phlebitis', 'Eye Injuries', 'Optic Nerve Injuries', 'Asthma-Chronic Obstructive Pulmonary Disease Overlap Syndrome', 'Fractures, Multiple', 'Carcinoma, Embryonal', 'Teratoma', 'Seminoma', 'Thymoma', 'Smith-Magenis Syndrome', 'Hypoplastic Left Heart Syndrome', 'Leishmaniasis, Cutaneous', 'Crush Syndrome', 'Lung, Hyperlucent', 'Flatfoot', 'Brain Stem Infarctions', 'Corneal Opacity', 'Epilepsy, Generalized', 'Sunburn', 'Maxillary Neoplasms', 'Menopause, Premature', 'Down Syndrome', 'Channelopathies', 'Leukemia, Large Granular Lymphocytic', 'Lymphoma, Large-Cell, Anaplastic', 'Urethritis', 'Antiphospholipid Syndrome', 'Myopia, Degenerative', 'Leukemia, T-Cell', 'Hypokalemic Periodic Paralysis', 'Paralyses, Familial Periodic', 'Labyrinthitis', 'Congenital Microtia', 'Goldenhar Syndrome', 'Rhinitis, Vasomotor', 'Spinal Cord Neoplasms', 'Tinea Pedis', 'Epileptic Syndromes', 'Echinococcosis, Pulmonary', 'Nijmegen Breakage Syndrome', 'Lice Infestations', 'Trigger Finger Disorder', 'Arachnoiditis', 'Escherichia coli Infections', 'Anterior Cruciate Ligament Injuries', 'Ichthyosiform Erythroderma, Congenital', 'Hemarthrosis', 'Carotid Artery Injuries', 'Vertebrobasilar Insufficiency', 'Miller Fisher Syndrome', 'Neuritis', 'Severe Dengue', 'Sarcoidosis, Pulmonary', 'Emphysematous Cholecystitis', 'Cat-Scratch Disease', 'Rhabdoid Tumor', 'Pulmonary Blastoma', 'Whipple Disease', 'Riboflavin Deficiency', 'Tooth Discoloration', 'Focal Dermal Hypoplasia', 'Gallbladder Diseases', 'Urethral Stricture', 'Cheyne-Stokes Respiration', 'Post-Dural Puncture Headache', 'Lyme Disease', 'Vaginal Discharge', 'Intracranial Hypertension', 'Fibrosarcoma', 'Neovascularization, Pathologic', 'Laryngomalacia', 'Corneal Endothelial Cell Loss', 'Familial Hypophosphatemic Rickets', 'Raynaud Disease', 'Epiglottitis', 'Supraglottitis', 'Splenic Infarction', 'Bile Reflux', 'Parental Death', 'Aortic Coarctation', 'Aphasia, Primary Progressive', 'Tonsillitis', 'Carcinoma, Papillary', 'Ectropion', 'Dry Socket', 'Bloom Syndrome', 'Stomatitis, Denture', 'Osteochondrosis', 'Neointima', 'Whiplash Injuries', 'Keratoconjunctivitis', 'Rhabdomyosarcoma, Alveolar', 'Nevus, Blue', 'Heart Neoplasms', 'Typhoid Fever', 'Carcinoma, Large Cell', 'Chronic Urticaria', 'Myocardial Reperfusion Injury', 'Hemorrhagic Fever, Crimean', 'Arm Injuries', 'Herpes Labialis', 'Gingival Hyperplasia', 'Nephrocalcinosis', 'Hypercalciuria', 'Hyperammonemia', 'Gyrate Atrophy', 'Vitamin D Deficiency', 'Obesity Hypoventilation Syndrome', 'Situs Inversus', 'Chiari-Frommel Syndrome', 'Neonatal Sepsis', 'Infant, Newborn, Diseases', 'Mastocytosis', 'Metatarsalgia', 'Angiofibroma', 'Tongue Neoplasms', 'Pelvic Girdle Pain', 'Neck Injuries', 'Sandhoff Disease', 'Epilepsy, Post-Traumatic', 'Granulomatosis with Polyangiitis', 'Oral Ulcer', 'Respiratory System Abnormalities', 'Glossitis, Benign Migratory', 'Acinetobacter Infections', 'Carcinoma, Transitional Cell', 'Enuresis', 'Hypergammaglobulinemia', 'Joint Loose Bodies', 'Pancreatitis, Chronic', 'Sweat Gland Diseases', 'Meningitis, Meningococcal', 'Giardiasis', 'Chorea', 'Epilepsy, Benign Neonatal', 'Complex Regional Pain Syndromes', 'Brain Death', 'Hernia, Femoral', 'Tooth Eruption, Ectopic', 'Erythema Infectiosum', 'Lymphoma, Primary Cutaneous Anaplastic Large Cell', 'Lymphomatoid Papulosis', 'Helminthiasis', 'Abdominal Injuries', 'Jaw Fractures', 'Multiple Acyl Coenzyme A Dehydrogenase Deficiency', 'Stevens-Johnson Syndrome', 'Osteochondrodysplasias', 'Panuveitis', 'Nasopharyngitis', 'Exotropia', 'Hirsutism', 'Red-Cell Aplasia, Pure', 'Mucolipidoses', 'Hepatitis, Alcoholic', 'Athetosis', 'Colic', 'Asphyxia', 'Femoral Neoplasms', 'Cholestasis, Intrahepatic', 'Prolactinoma', 'ACTH-Secreting Pituitary Adenoma', 'Peripheral Nervous System Neoplasms', 'Autoimmune Pancreatitis', 'Dacryocystitis', 'Sialadenitis', 'Periapical Periodontitis', 'Bone Cysts', 'Leukemia, Erythroblastic, Acute', 'Burkitt Lymphoma', 'Vector Borne Diseases', 'Dirofilariasis', 'Anaplasmosis', 'Lymphangiectasis', 'Sturge-Weber Syndrome', 'Hiccup', 'Lacrimal Duct Obstruction', 'Dyslexia', 'Parotid Neoplasms', 'Delayed Emergence from Anesthesia', 'Tay-Sachs Disease', 'Auditory Diseases, Central', 'Coxa Vara', 'Dysmenorrhea', 'Hypoventilation', 'Nail Diseases', 'Urinary Calculi', 'Cerebral Ventricle Neoplasms', 'Pneumovirus Infections', 'Esophagitis', 'Hernia, Abdominal', 'Embolism, Paradoxical', 'Aphakia', 'Lentivirus Infections', 'Hypertension, Renovascular', 'Cerebellar Neoplasms', 'Gait Apraxia', 'Hearing Loss, Noise-Induced', 'Anomia', 'Cardiac Conduction System Disease', 'Neonatal Brachial Plexus Palsy', 'Pellagra', 'Enterocolitis, Necrotizing', 'Myxedema', 'Composite Lymphoma', 'Leptospirosis', 'Spina Bifida Occulta', 'Lung Abscess', 'Empyema', 'Pseudohypoparathyroidism', 'Chromosome Disorders', 'Iris Diseases', 'Kluver-Bucy Syndrome', 'Pneumonia, Mycoplasma', 'Carotid Artery Thrombosis', 'Barth Syndrome', 'Cholera', 'Cattle Diseases', 'Trichothiodystrophy Syndromes', 'beta-Thalassemia', 'Myopathies, Nemaline', 'Myotonia Congenita', 'Ductus Arteriosus, Patent', 'Hyperostosis', 'Slipped Capital Femoral Epiphyses', 'Carcinoma, Neuroendocrine', 'Fibroma, Ossifying', 'Herpangina', 'Hand, Foot and Mouth Disease', 'Brucellosis', 'Pulmonary Veno-Occlusive Disease', 'Screw Worm Infection', 'Candidiasis, Oral', 'Primary Immunodeficiency Diseases', 'Dysgammaglobulinemia', 'Dentofacial Deformities', 'Mandibular Neoplasms', 'Ochronosis', 'Fascioliasis', 'Aniseikonia', 'Epiretinal Membrane', 'Macular Edema', 'Hyperparathyroidism, Secondary', 'Diverticulum, Colon', 'Failed Back Surgery Syndrome', 'Hyalinosis, Systemic', 'Neuromuscular Manifestations', 'Lymphoma, Primary Effusion', 'Yin Deficiency', 'Carcinoma, Islet Cell', 'Paraparesis', 'Nasal Polyps', 'Dupuytren Contracture', 'Esophageal Stenosis', 'Forearm Injuries', 'Echinococcosis', 'Cranial Nerve Injuries', 'Multiple Sulfatase Deficiency Disease', 'Extensively Drug-Resistant Tuberculosis', 'Polyradiculopathy', 'Foot Injuries', 'Osteoradionecrosis', 'Galactosemias', 'Toxoplasmosis, Cerebral', 'Pancreatic Cyst', 'Arcus Senilis', 'Mediastinal Neoplasms', 'Superior Vena Cava Syndrome', 'Intracranial Hypotension', 'Lymphoma, AIDS-Related', 'Histiocytoma, Benign Fibrous', 'Skin Diseases, Metabolic', 'Hemangioendothelioma', 'Ophthalmoplegia', 'Pseudobulbar Palsy', 'Arterio-Arterial Fistula', 'Intestinal Diseases, Parasitic', 'Hyperphagia', 'Mastitis', 'Anterior Wall Myocardial Infarction', "Sister Mary Joseph's Nodule", 'Arthrogryposis', 'Beckwith-Wiedemann Syndrome', 'Hematemesis', 'Usher Syndromes', 'Malformations of Cortical Development, Group II', 'Blindness, Cortical', 'Photophobia', 'Osteosclerosis', 'Fasciitis', 'Li-Fraumeni Syndrome', 'Shwachman-Diamond Syndrome', 'Polydipsia', 'Hearing Loss, Bilateral', 'Adenoma, Pleomorphic', 'Neurogenic Bowel', 'Lead Poisoning', 'Alveolitis, Extrinsic Allergic', 'Brain Abscess', 'Immunoglobulin Light-chain Amyloidosis', 'Bulbo-Spinal Atrophy, X-Linked', 'Pneumonia, Atypical Interstitial, of Cattle', 'Osteoporosis, Postmenopausal', 'Parathyroid Diseases', 'Focal Infection', 'Hypertelorism', 'Hand Deformities, Congenital', 'Scleritis', 'Iritis', 'Blepharospasm', 'Gynecomastia', 'Papilloma, Choroid Plexus', 'Cystadenocarcinoma, Mucinous', 'Anisometropia', 'Hemospermia', 'Herpes Simplex', 'Leukemia-Lymphoma, Adult T-Cell', 'Carcinoma, Signet Ring Cell', 'Salivary Gland Diseases', 'Popliteal Cyst', 'Filariasis', 'Skin Diseases, Parasitic', 'Leukoencephalopathy, Progressive Multifocal', 'Amyloid Neuropathies, Familial', 'Lingual Thyroid', 'Seizures, Febrile', 'Boutonneuse Fever', 'Psoas Abscess', 'Body Weight Changes', 'Chordoma', 'Skin Diseases, Papulosquamous', 'Rhabdomyosarcoma', 'Vitamin B Deficiency', 'Epilepsia Partialis Continua', 'Ichthyosis, X-Linked', 'Autoimmune Hypophysitis', 'Meningitis, Cryptococcal', 'Apraxia, Ideomotor', 'Urethral Diseases', 'Hepatoblastoma', 'Retroperitoneal Neoplasms', 'Paraganglioma', 'Oliguria', 'Chlamydia Infections', 'Azotemia', 'Oligomenorrhea', 'Alcohol Withdrawal Seizures', 'Liver Abscess, Pyogenic', 'Rodent Diseases', 'Mitral Valve Prolapse', 'Alkalosis', 'Temporomandibular Joint Dysfunction Syndrome', 'Synovial Cyst', 'Lennox Gastaut Syndrome', 'Candidiasis, Invasive', 'Pyoderma', 'Tinea', 'Tinea Versicolor', 'Bile Duct Diseases', 'Landau-Kleffner Syndrome', 'Ventricular Flutter', 'Erythema Multiforme', 'Schistosomiasis haematobia', 'Hypocapnia', 'Paresthesia', 'Dracunculiasis', 'Birdshot Chorioretinopathy', 'Factor VII Deficiency', 'Factor XI Deficiency', 'Vulvar Diseases', 'Vulvar Lichen Sclerosus', 'Renal Artery Obstruction', 'Tricuspid Valve Stenosis', 'Diabetes Insipidus, Nephrogenic', 'Empyema, Subdural', 'Cerebral Hemorrhage, Traumatic', 'Retinal Telangiectasis', 'Polyomavirus Infections', 'HIV Seropositivity', 'Liver Abscess', 'Paraneoplastic Endocrine Syndromes', 'Uniparental Disomy', 'Cholesterol Ester Storage Disease', 'Cyanosis', 'Esophageal Diseases', 'Abnormalities, Multiple', 'Chorioretinitis', 'Meningitis, Listeria', 'Purpura, Thrombocytopenic', "Hallermann's Syndrome", 'Dandy-Walker Syndrome', 'Postpericardiotomy Syndrome', 'Biliary Atresia', 'Periprosthetic Fractures', 'Tennis Elbow', 'Long Term Adverse Effects', 'Spastic Paraplegia, Hereditary', 'Solitary Fibrous Tumor, Pleural', 'Lateral Medullary Syndrome', 'Hemoglobinuria, Paroxysmal', 'Superinfection', 'Pudendal Neuralgia', 'Jacobsen Distal 11q Deletion Syndrome', 'Mucopolysaccharidosis I', 'Hernia, Diaphragmatic', 'Corneal Wavefront Aberration', 'Amebiasis', 'Anthracosis', 'Injection Site Reaction', 'Fasciitis, Plantar', 'Respiratory Aspiration', 'Pseudomyxoma Peritonei', 'Laryngostenosis', 'Low Tension Glaucoma', "Agricultural Workers' Diseases", 'Hernia, Obturator', 'Epidermolysis Bullosa', 'Anodontia', 'Encephalitis, Arbovirus', 'Costello Syndrome', 'Jaw Neoplasms', 'Telangiectasia, Hereditary Hemorrhagic', 'Lymphomatoid Granulomatosis', 'Lymphoma, Extranodal NK-T-Cell', 'Multifocal Choroiditis', 'Glycogen Storage Disease Type V', 'Melanoma, Experimental', 'Meningism', 'Alexander Disease', 'Alopecia', 'Postthrombotic Syndrome', 'Klinefelter Syndrome', 'Achlorhydria', 'Esophageal Fistula', 'Carcinoma, Lobular', 'Jaundice, Obstructive', 'Femoracetabular Impingement', 'Synovitis, Pigmented Villonodular', 'Focal Nodular Hyperplasia', 'Langerhans Cell Sarcoma', 'Sexually Transmitted Diseases', 'Mercury Poisoning, Nervous System', 'Orbital Diseases', 'Granuloma, Pyogenic', 'Pneumocystis Infections', 'Leukodystrophy, Metachromatic', 'Alstrom Syndrome', 'Bardet-Biedl Syndrome', 'Epidural Neoplasms', 'Hand Deformities', 'Neoplasm Regression, Spontaneous', 'Callosities', 'Pentalogy of Cantrell', 'Iridocorneal Endothelial Syndrome', 'Bile Duct Neoplasms', 'Puerperal Infection', 'Otitis Externa', 'Blastocystis Infections', 'Deltaretrovirus Infections', 'Mucormycosis', 'Ectromelia, Infectious', 'Isolated Noncompaction of the Ventricular Myocardium', 'Calciphylaxis', 'Rickets, Hypophosphatemic', 'Parotitis', 'Nocturnal Myoclonus Syndrome', 'Wernicke Encephalopathy', 'Moyamoya Disease', 'Microsporidiosis', 'Ameloblastoma', 'Mushroom Poisoning', 'Haemophilus Infections', 'Laryngeal Neoplasms', 'Papillon-Lefevre Disease', 'Paraneoplastic Syndromes, Nervous System', 'Vitamin K Deficiency Bleeding', 'Flank Pain', 'Angiomyolipoma', 'Parakeratosis', 'Polyploidy', 'Panophthalmitis', 'Argyria', 'Myasthenic Syndromes, Congenital', 'Aphasia, Broca', 'Epididymitis', 'Posterior Tibial Tendon Dysfunction', 'Radiodermatitis', 'Otorhinolaryngologic Diseases', 'Hypertension, Malignant', 'Dwarfism', 'Hypospadias', 'Acute Chest Syndrome', 'Lathyrism', 'Acrocephalosyndactylia', 'Hyperlactatemia', 'Pathological Conditions, Anatomical', 'Epidermolysis Bullosa Acquisita', 'Pemphigus', 'Furunculosis', 'Exostoses', 'Chromothripsis', 'Alcohol Amnestic Disorder', 'Microaneurysm', 'Q Fever', 'Purpura, Thrombocytopenic, Idiopathic', 'Retinal Dystrophies', 'Osteopetrosis', 'Rectal Diseases', 'Lymphoma, T-Cell, Peripheral', 'Glaucoma, Neovascular', 'Osteoblastoma', 'Esthesioneuroblastoma, Olfactory', 'Penile Neoplasms', 'Psychophysiologic Disorders', 'Vesico-Ureteral Reflux', 'Nephritis, Hereditary', 'Acneiform Eruptions', 'Hypohidrosis', 'Peritoneal Fibrosis', 'Erythrokeratodermia Variabilis', 'Staphylococcal Food Poisoning', 'Jet Lag Syndrome', 'Morning Sickness', 'Optic Atrophy', 'Central Nervous System Cysts', 'Sciatica', 'Cerebral Amyloid Angiopathy, Familial', 'Osteoma', 'Craniofacial Fibrous Dysplasia', 'Sporotrichosis', 'Neoplasms, Germ Cell and Embryonal', 'Glycosuria', 'Lipid Metabolism, Inborn Errors', 'Adenoma, Acidophil', 'Cholecystolithiasis', 'Vagus Nerve Diseases', 'Ichthyosis', 'Endodermal Sinus Tumor', 'Muscular Dystrophies, Limb-Girdle', 'Microphthalmos', 'Neurofibroma', 'Pachyonychia Congenita', 'Hamartoma', 'Optic Atrophy, Hereditary, Leber', 'Subdural Effusion', 'Premature Ejaculation', 'Mediastinal Diseases', 'Plasmablastic Lymphoma', 'Central Nervous System Parasitic Infections', 'Granulomatous Disease, Chronic', 'Pseudotumor Cerebri', 'Muscular Dystrophy, Facioscapulohumeral', 'Botulism', 'Mucopolysaccharidosis VII', 'Bronchiectasis', 'Atypical Squamous Cells of the Cervix', 'Body Weight', 'Pallor', 'Goiter, Nodular', 'Bronchial Neoplasms', 'Carcinoid Tumor', 'Argininosuccinic Aciduria', 'Lead Poisoning, Nervous System', 'Cryptococcosis', 'Ascorbic Acid Deficiency', 'Mucopolysaccharidosis II', 'Exostoses, Multiple Hereditary', 'Upper Extremity Deep Vein Thrombosis', 'Rhinitis, Allergic, Perennial', 'Leydig Cell Tumor', 'Duodenal Ulcer', 'Myocardial Stunning', 'Alphavirus Infections', 'Sleep Apnea, Central', 'Endarteritis', 'Metabolic Side Effects of Drugs and Substances', 'Epidermolysis Bullosa, Junctional', 'AIDS-Related Opportunistic Infections', 'Hyperlipidemia, Familial Combined', 'Tuberculoma, Intracranial', 'Neurofibrosarcoma', 'Neuroectodermal Tumors', 'Hypopharyngeal Neoplasms', 'Sarcoma, Myeloid', 'Osteochondroma', 'Paranasal Sinus Neoplasms', 'Pallister-Hall Syndrome', 'Serositis', 'Periapical Diseases', 'Leg Length Inequality', 'Hypoglossal Nerve Diseases', 'Adenoma, Chromophobe', 'Cocaine-Related Disorders', 'Epiphyses, Slipped', 'Tracheal Neoplasms', 'Incisional Hernia', 'Hemopneumothorax', 'Fluorosis, Dental', 'Severe Acute Malnutrition', 'Factor X Deficiency', 'Xerophthalmia', 'Psittacosis', 'Malignant Hyperthermia', 'Marijuana Abuse', 'Disease Resistance', 'Mucopolysaccharidosis VI', 'Tumor Lysis Syndrome', 'Symptom Flare Up', 'Rubella Syndrome, Congenital', 'Colonic Pseudo-Obstruction', 'Dental Enamel Hypoplasia', 'Dyspnea, Paroxysmal', "Paget's Disease, Mammary", 'Oligospermia', 'Tuberculosis, Pleural', 'Leiomyomatosis', 'Retinal Drusen', 'Facial Neoplasms', 'Perinatal Death', 'Squamous Intraepithelial Lesions', 'Porphyrias, Hepatic', 'Pantothenate Kinase-Associated Neurodegeneration', 'Lymphangioma, Cystic', 'Hypoaldosteronism', 'Elephantiasis', 'Laron Syndrome', 'Scimitar Syndrome', 'Ankylosis', 'Lymphangioleiomyomatosis', 'Pulmonary Eosinophilia', 'Postpoliomyelitis Syndrome', 'Heel Spur', 'Osteitis', 'Myxoma', 'Jaundice, Neonatal', 'Nevus, Halo', 'Neurocysticercosis', 'Hamman-Rich Syndrome', 'Monkey Diseases', 'Pneumonia, Ventilator-Associated', 'Hypophosphatemia, Familial', 'Plasmacytoma', 'Zollinger-Ellison Syndrome', 'Steatorrhea', 'Anus Neoplasms', 'Epidural Abscess', 'Glycogen Storage Disease Type IIb', 'Alexia, Pure', 'Substance Abuse, Oral', 'HIV-Associated Lipodystrophy Syndrome', 'Hyperargininemia', 'Ascariasis', 'Atrial Premature Complexes', 'Food Hypersensitivity', 'Carcinoma, Intraductal, Noninfiltrating', 'Lipidoses', 'Phantom Limb', 'Lown-Ganong-Levine Syndrome', 'Hearing Loss, Unilateral', 'Leukemia, Hairy Cell', 'Middle Lobe Syndrome', 'Urethral Obstruction', 'Infarction, Anterior Cerebral Artery', 'Sarcoma, Endometrial Stromal', 'Hypertensive Encephalopathy', 'Lymphoma, Large B-Cell, Diffuse', 'Rectovaginal Fistula', 'Retrobulbar Hemorrhage', 'Mandibular Diseases', 'Aortic Stenosis, Supravalvular', 'Citrullinemia', 'Sinoatrial Block', 'Histiocytic Disorders, Malignant', 'Anemia, Hypochromic', 'Paracoccidioidomycosis', 'Adenosarcoma', 'Nails, Malformed', 'Toxemia', 'Embolism, Cholesterol', 'Blue Toe Syndrome', 'Glycogen Storage Disease Type III', 'Infectious Mononucleosis', 'Echogenic Bowel', 'Hemothorax', 'Abortion, Septic', 'Antley-Bixler Syndrome Phenotype', 'Hypersplenism', 'Genital Neoplasms, Male', 'Eye Neoplasms', 'Scheuermann Disease', 'Hypercementosis', 'Brain Stem Hemorrhage, Traumatic', 'Genetic Predisposition to Disease', 'Autonomic Dysreflexia', 'Elephantiasis, Filarial', 'Anuria', 'Prehypertension', 'Brachydactyly', 'Thrombasthenia', 'Afibrinogenemia', 'Adenomyosis', 'Leukemic Infiltration', 'Granulosa Cell Tumor', 'Vitelliform Macular Dystrophy', 'Fallopian Tube Neoplasms', 'Alkalosis, Respiratory', 'Acidosis, Respiratory', 'Diastasis, Bone', 'Tooth Ankylosis', 'Cysts', 'Tetraploidy', 'Syringoma', 'Neurodermatitis', 'Pneumonia of Calves, Enzootic', 'Entropion', 'Ophthalmoplegia, Chronic Progressive External', 'Actinomycosis', 'Asthenozoospermia', 'Mouth, Edentulous', 'Laurence-Moon Syndrome', 'Buruli Ulcer', 'Prostatic Neoplasms, Castration-Resistant', 'Glomerulonephritis, Membranoproliferative', 'Leukemia, Myelomonocytic, Juvenile', 'Laryngitis', 'Granuloma Annulare', 'Hookworm Infections', 'Toxoplasmosis, Congenital', 'POEMS Syndrome', 'Choroid Plexus Neoplasms', 'Hereditary Sensory and Motor Neuropathy', 'Retrognathia', 'Urticaria Pigmentosa', 'Leprosy, Lepromatous', 'Dermatomycoses', 'Cone-Rod Dystrophies', 'Thoracic Neoplasms', 'Enchondromatosis', 'Paramyxoviridae Infections', 'Vasculitis, Leukocytoclastic, Cutaneous', 'Neuralgia, Postherpetic', 'Cryptorchidism', 'Tubular Sweat Gland Adenomas', 'Acute Febrile Encephalopathy', 'Empyema, Pleural', 'Fetal Nutrition Disorders', 'Adenoma, Liver Cell', 'Granuloma, Foreign-Body', 'Leber Congenital Amaurosis', 'Vaccinia', 'Spherocytosis, Hereditary', 'Reticulocytosis', 'Gastric Antral Vascular Ectasia', 'Polyradiculoneuropathy, Chronic Inflammatory Demyelinating', 'Myelinolysis, Central Pontine', 'Syphilis', 'Ectoparasitic Infestations', 'Lipodystrophy, Congenital Generalized', 'Myoclonic Epilepsy, Juvenile', 'Pulmonary Infarction', 'Talipes', 'Cystinuria', 'Foramen Ovale, Patent', 'Chorioamnionitis', 'Leukostasis', 'Vulvodynia', 'Spotted Fever Group Rickettsiosis', 'Ureteral Calculi', 'Multiple Sclerosis, Chronic Progressive', 'Ulnar Neuropathies', 'Abetalipoproteinemia', 'Tooth Abnormalities', 'Organophosphate Poisoning', 'Acrospiroma', 'Thrombocytopenia, Neonatal Alloimmune', 'Angina Pectoris, Variant', 'Phagocyte Bactericidal Dysfunction', 'Glossitis', 'Lichen Planus', 'Adenoviridae Infections', 'Amnesia, Retrograde', 'Kallmann Syndrome', 'Glycogen Storage Disease', 'Carbohydrate Metabolism, Inborn Errors', 'Malignant Catarrh', 'Bezoars', 'Oropharyngeal Neoplasms', 'Aniridia', 'Birt-Hogg-Dube Syndrome', 'Pancreatitis, Alcoholic', 'T-Lymphocytopenia, Idiopathic CD4-Positive', 'Emergence Delirium', 'Eye Diseases, Hereditary', 'Pyomyositis', 'Glycosuria, Renal', 'Myelodysplastic-Myeloproliferative Diseases', 'Vaginosis, Bacterial', 'Emergencies', 'Mononeuropathies', 'Aortic Stenosis, Subvalvular', 'Buschke-Lowenstein Tumor', 'Pneumatosis Cystoides Intestinalis', 'Erythroblastosis, Fetal', 'Trisomy 13 Syndrome', 'Vocal Cord Paralysis', 'Morton Neuroma', 'Tarlov Cysts', 'Bulimia', 'Genu Varum', 'Tachycardia, Sinoatrial Nodal Reentry', 'Laryngeal Diseases', 'Diffuse Axonal Injury', 'Acute Generalized Exanthematous Pustulosis', 'Propionic Acidemia', 'Brachial Plexus Neuritis', 'Choroidal Effusions', 'Autoimmune Diseases of the Nervous System', 'Osteitis Fibrosa Cystica', 'Tracheitis', 'Cytomegalovirus Retinitis', 'Carney Complex', 'Syringomyelia', 'Triple Negative Breast Neoplasms', 'Anomalous Left Coronary Artery', 'Mevalonate Kinase Deficiency', 'Spinal Muscular Atrophies of Childhood', 'Prosthesis Failure', 'Megacolon, Toxic', 'War-Related Injuries', 'Exanthema Subitum', 'Myoepithelioma', 'Caliciviridae Infections', 'Bone Demineralization, Pathologic', 'HIV Enteropathy', 'Lymphadenopathy', 'Epistaxis', 'Hand-Foot Syndrome', 'Vascular Neoplasms', 'Dental Occlusion, Traumatic', 'Ganglioglioma', 'Pancreatitis, Acute Hemorrhagic', 'Severe Combined Immunodeficiency', 'Parotid Diseases', 'Abscess', 'Gonadoblastoma', 'Fraser Syndrome', 'Xanthogranuloma, Juvenile', 'Taeniasis', 'Blast Injuries', 'Enterocolitis, Pseudomembranous', 'Chlamydial Pneumonia', 'Peritonsillar Abscess', 'Sarcoma, Synovial', 'Histiocytoma, Malignant Fibrous', 'Pityriasis', 'Hydroa Vacciniforme', 'Environmental Illness', 'Pituitary ACTH Hypersecretion', 'Chlamydophila Infections', 'Ganglion Cysts', 'Hyperesthesia', 'Anus Diseases', 'Tangier Disease', 'Optic Nerve Glioma', 'Angiolymphoid Hyperplasia with Eosinophilia', 'Pregnancy, Tubal', 'Acatalasia', 'Pectus Carinatum', 'Leukemoid Reaction', 'Osteolysis, Essential', 'Herpes Zoster Ophthalmicus', 'Corneal Ulcer', 'Otosclerosis', 'Neuroma', 'Corneal Injuries', 'Pathologic Processes', 'Arteriosclerosis Obliterans', 'Mesonephroma', 'Hantavirus Infections', 'Hyperventilation', 'Leriche Syndrome', 'Median Arcuate Ligament Syndrome', 'Osteitis Deformans', 'Dyssomnias', 'Brown-Sequard Syndrome', 'Anterior Spinal Artery Syndrome', 'Barotrauma', 'Needlestick Injuries', 'Tuberculosis, Urogenital', 'Thromboangiitis Obliterans', 'Ectopia Cordis', 'Pain, Procedural', 'Brain Contusion', 'Trematode Infections', 'Photosensitivity Disorders', 'Nondisjunction, Genetic', 'Oxyuriasis', 'Subphrenic Abscess', 'Aneurysm, Infected', 'Degloving Injuries', 'Tertiary Lymphoid Structures', 'Keratoconjunctivitis Sicca', 'Fibromatosis, Aggressive', 'Cystadenoma, Serous', 'Cystadenoma, Mucinous', 'Tricuspid Atresia', 'Urinary Fistula', 'Lambert-Eaton Myasthenic Syndrome', 'Polycystic Kidney, Autosomal Recessive', 'HTLV-I Infections', 'Truncus Arteriosus, Persistent', 'Gram-Positive Bacterial Infections', 'Tarsal Tunnel Syndrome', 'Non-ST Elevated Myocardial Infarction', 'Stomatitis, Aphthous', 'Rupture, Spontaneous', 'Necrobiosis Lipoidica', 'Porokeratosis', 'Balanitis', 'Phimosis', 'Hepatitis D, Chronic', 'Fibrocystic Breast Disease', 'Mental Retardation, X-Linked', 'Ancylostomiasis', 'Maternal Death', 'Acanthamoeba Keratitis', 'Arsenic Poisoning', 'Scleroderma, Diffuse', 'Post-Lyme Disease Syndrome', 'Teratocarcinoma', 'Silver-Russell Syndrome', 'Sublingual Gland Neoplasms', 'Hemianopsia', 'Trypanosomiasis', 'Kidney Papillary Necrosis', 'Megalencephaly', 'Chemical and Drug Induced Liver Injury, Chronic', 'Tuberculosis, Lymph Node', 'Mycetoma', 'Loeys-Dietz Syndrome', 'Pregnancy, Angular', 'Infectious Encephalitis', 'Menkes Kinky Hair Syndrome', 'Genital Diseases, Female', 'Leukomalacia, Periventricular', 'Pneumorrhachis', 'Head Injuries, Closed', 'Muir-Torre Syndrome', 'Border Disease', 'Craniofacial Dysostosis', 'Hyperglycinemia, Nonketotic', 'Feline Panleukopenia', 'Lymphogranuloma Venereum', 'Locked-In Syndrome', 'Otorhinolaryngologic Neoplasms', 'Frostbite', 'Vesicular Stomatitis', 'Carcinoma, Verrucous', 'Lacrimal Apparatus Diseases', 'Lymphocytic Choriomeningitis', 'Bernard-Soulier Syndrome', 'Bone Diseases, Endocrine', 'Alcohol Withdrawal Delirium', 'Cracked Tooth Syndrome', "Bowen's Disease", 'Fibroadenoma', 'Fetal Death', 'Retinopathy of Prematurity', 'Trichuriasis', 'Renal Colic', 'Nevus, Pigmented', 'Ileal Diseases', 'Unilateral Breast Neoplasms', 'Bone Cysts, Aneurysmal', 'Giant Cell Tumors', 'Strongyloidiasis', 'Stupor', 'Ehrlichiosis', 'Necrolytic Migratory Erythema', 'ST Elevation Myocardial Infarction', 'Proctocolitis', 'Vascular Ring', 'Vasoplegia', 'Staghorn Calculi', 'Dermatitis, Irritant', 'Pancoast Syndrome', '46, XX Testicular Disorders of Sex Development', 'MPTP Poisoning', 'Hemosiderosis', 'Nephrogenic Fibrosing Dermopathy', 'Susac Syndrome', 'Sneddon Syndrome', 'Pseudophakia', 'Skull Fractures', 'Goiter, Substernal', 'Spondylarthritis', 'Lymphangiectasis, Intestinal', 'Fibroma, Desmoplastic', 'Flavivirus Infections', 'Adenocarcinoma, Bronchiolo-Alveolar', 'Anti-Glomerular Basement Membrane Disease', 'Keratoacanthoma', 'Univentricular Heart', 'Lipomatosis', 'Anorectal Malformations', 'Overnutrition', 'Protozoan Infections', 'Pruritus Ani', 'Protein C Deficiency', 'Urachal Cyst', 'Lupus Erythematosus, Discoid', 'Neoplasm Recurrence, Local', 'Staphylococcal Scalded Skin Syndrome', 'Insomnia, Fatal Familial', 'Cardiomyopathy, Alcoholic', 'Anemia, Pernicious', 'Tuberculosis, Hepatic', 'Protoporphyria, Erythropoietic', 'Prune Belly Syndrome', 'Androgen-Insensitivity Syndrome', 'Clubfoot', 'Hip Contracture', 'Cysticercosis', 'Prolapse', 'Port-Wine Stain', 'Carcinoma, Bronchogenic', 'Keratoconus', 'Splenic Rupture', 'Pain, Intractable', 'Shoulder Pain', 'Chondroblastoma', 'Accessory Atrioventricular Bundle', 'Foot-and-Mouth Disease', 'Encephalomalacia', 'Abdominal Neoplasms', 'Cone Dystrophy', 'Wolf-Hirschhorn Syndrome', 'Enterocolitis, Neutropenic', 'Sialorrhea', 'Retinal Dysplasia', 'Neuroectodermal Tumor, Melanotic', 'Weill-Marchesani Syndrome', 'Margins of Excision', 'Myositis Ossificans', 'Macroglossia', 'Canaliculitis', 'Anencephaly', 'Slit Ventricle Syndrome', 'Polydipsia, Psychogenic', 'Reproductive Tract Infections', 'Rhabdomyosarcoma, Embryonal', 'Steroid Metabolism, Inborn Errors', 'Peritoneal Diseases', 'HIV Wasting Syndrome', 'Sprains and Strains', 'Leukemia, Biphenotypic, Acute', 'Airway Remodeling', 'Endometrial Stromal Tumors', 'Uterine Neoplasms', 'Adenomyoepithelioma', 'Porcine Reproductive and Respiratory Syndrome', 'Tachycardia, Paroxysmal', 'Rheumatoid Vasculitis', 'Classical Lissencephalies and Subcortical Band Heterotopias', 'Wolff-Parkinson-White Syndrome', 'Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis', 'Limbic Encephalitis', 'Aphasia, Conduction', 'Impotence, Vasculogenic', 'Yaws', 'Eccrine Porocarcinoma', 'Dermoid Cyst', 'Endocardial Fibroelastosis', 'Hyperlipoproteinemia Type I', 'Carbamoyl-Phosphate Synthase I Deficiency Disease', 'Psychoses, Alcoholic', 'Gram-Negative Bacterial Infections', 'Corneal Neovascularization', 'Glucagonoma', 'High Pressure Neurological Syndrome', 'Lacerations', 'Non-Filarial Lymphedema', 'Aggressive Periodontitis', 'De Lange Syndrome', 'Tooth Migration', 'Exophthalmos', 'Blastomycosis', 'Cystinosis', 'Intestinal Polyps', 'Foreign-Body Reaction', 'Chromosome Breakage', 'Smith-Lemli-Opitz Syndrome', 'Adenofibroma', 'Listeriosis', 'Lactose Intolerance', 'Meningeal Carcinomatosis', 'Acalculous Cholecystitis', 'WAGR Syndrome', 'Herpes Zoster Oticus', 'Lemierre Syndrome', 'Enteritis, Transmissible, of Turkeys', 'Coma, Post-Head Injury', 'Hydatidiform Mole', 'Livedo Reticularis', 'Asthma, Exercise-Induced', 'Glycogen Storage Disease Type VII', 'Cecal Diseases', 'Angiomyoma', 'Influenza, Human', 'Ileus', 'Mucopolysaccharidosis IV', 'Adenoma, Basophil', 'Porphyria, Acute Intermittent', 'Preleukemia', 'Dysentery, Bacillary', 'Wrist Injuries', 'Barrett Esophagus', 'Vesicovaginal Fistula', 'Carcinoid Heart Disease', 'Malignant Carcinoid Syndrome', 'Opium Dependence', 'Enteropathy-Associated T-Cell Lymphoma', 'Asthma, Aspirin-Induced', 'Lipoid Proteinosis of Urbach and Wiethe', 'Leukemia, Prolymphocytic, T-Cell', 'Kernicterus', 'Neuroaspergillosis', 'Melioidosis', 'Hydrocephalus, Normal Pressure', 'Acanthoma', 'Tick Paralysis', 'Maple Syrup Urine Disease', 'Multiple Endocrine Neoplasia Type 1', 'Trophoblastic Neoplasms', 'Leukemia, Prolymphocytic', 'Amnesia, Transient Global', 'Hyperamylasemia', 'Myotonic Disorders', 'Necrobiotic Xanthogranuloma', 'Necrobiotic Disorders', 'Rickets', 'Larva Migrans', 'Silicotuberculosis', 'Orbital Cellulitis', 'Jaundice, Chronic Idiopathic', 'Otitis Media, Suppurative', 'Mastodynia', 'Massive Hepatic Necrosis', 'Geographic Atrophy', 'Bone Marrow Neoplasms', 'Waardenburg Syndrome', 'Empty Sella Syndrome', 'Monckeberg Medial Calcific Sclerosis', 'Neoplasms, Ductal, Lobular, and Medullary', 'Crigler-Najjar Syndrome', 'Respiratory Tract Neoplasms', 'Articulation Disorders', 'Jejunal Diseases', 'Familial Exudative Vitreoretinopathies', 'Peliosis Hepatis', 'Mouth Abnormalities', 'Gastrinoma', 'Thymus Hyperplasia', 'Hypertension, Pregnancy-Induced', 'Pelvic Infection', 'Febrile Neutropenia', 'Adnexal Diseases', 'Platybasia', 'Duodenitis', 'Chondromatosis', 'Nasal Septal Perforation', 'Abortion, Veterinary', 'Henipavirus Infections', 'Ciliary Motility Disorders', 'Heart Aneurysm', 'Cadmium Poisoning', 'Maxillary Diseases', 'Branchio-Oto-Renal Syndrome', 'Glycogen Storage Disease Type I', 'Pouchitis', 'Thyroiditis, Subacute', 'Otitis Media with Effusion', 'Mediastinitis', 'Multiple Carboxylase Deficiency', 'Adenomatoid Tumor', 'Central Nervous System Venous Angioma', 'Hypertrichosis', 'Cholesteatoma, Middle Ear', 'Congenital Disorders of Glycosylation', 'Hypoprothrombinemias', 'Sheep Diseases', 'Tracheoesophageal Fistula', 'Trigeminal Nerve Diseases', 'Acidosis, Renal Tubular', 'Angelman Syndrome', 'Syphilis, Congenital', 'Pericarditis, Constrictive', 'Isaacs Syndrome', 'Hypertrophy, Right Ventricular', 'Paralysis, Obstetric', 'MELAS Syndrome', 'MERRF Syndrome', 'Polychondritis, Relapsing', 'Digital Dermatitis', 'Reye Syndrome', 'Cerebral Ventriculitis', 'Pyelitis', 'Trichiasis', 'Gynatresia', 'Asthma, Occupational', 'Vocal Cord Dysfunction', 'Latex Hypersensitivity', 'Narcotic-Related Disorders', 'Adenocarcinoma, Scirrhous', 'Polycystic Kidney, Autosomal Dominant', 'Chondromalacia Patellae', 'Paraneoplastic Syndromes, Ocular', 'Hyperoxaluria', 'Alcoholic Korsakoff Syndrome', 'Rhinitis, Atrophic', 'Amaurosis Fugax', 'Oral Submucous Fibrosis', 'Chilaiditi Syndrome', 'Duane Retraction Syndrome', 'Paratyphoid Fever', 'Trench Fever', 'Typhus, Endemic Flea-Borne', 'Furcation Defects', 'Porphyria Cutanea Tarda', 'Urinary Bladder, Underactive', 'Scrapie', 'Myokymia', 'Retroviridae Infections', 'Mycosis Fungoides', 'Paraparesis, Tropical Spastic', 'Erysipeloid', 'Sweet Syndrome', 'Felty Syndrome', 'Actinomycosis, Cervicofacial', 'Smear Layer', 'Endolymphatic Hydrops', 'Glossalgia', 'Epilepsy, Rolandic', 'Krukenberg Tumor', 'Walker-Warburg Syndrome', 'Pulmonary Subvalvular Stenosis', 'Adrenal Gland Diseases', 'Body Remains', 'Hermanski-Pudlak Syndrome', 'Heroin Dependence', 'Serratia Infections', 'Thyroid Crisis', 'Vibrio Infections', 'Hemoglobinuria', 'Retropharyngeal Abscess', 'Petrositis', 'Hyperpituitarism', 'Alcohol-Induced Disorders, Nervous System', 'Colorado Tick Fever', 'Diastasis, Muscle', 'Focal Infection, Dental', 'Wasting Disease, Chronic', 'Hypobetalipoproteinemias', 'Ganglioneuroblastoma', 'Hyperlipoproteinemia Type III', 'Nuchal Cord', 'Craniomandibular Disorders', 'Anaplasia', 'Neoplasms, Vascular Tissue', 'Genital Diseases, Male', 'Myoglobinuria', 'Myocardial Bridging', 'Dysentery, Amebic', 'Inferior Wall Myocardial Infarction', 'Choroid Hemorrhage', 'Yersinia Infections', 'Adenocarcinoma, Papillary', 'Triploidy', 'Vaginal Diseases', 'Adamantinoma', 'Cherubism', 'Nicolau Syndrome', 'Nesidioblastosis', 'Heartburn', 'Neurocutaneous Syndromes', 'Alcohol-Related Disorders', 'Postphlebitic Syndrome', 'Hemobilia', 'Esophageal Spasm, Diffuse', 'Pilomatrixoma', 'Paraparesis, Spastic', 'Peptic Ulcer Hemorrhage', 'Agenesis of Corpus Callosum', 'Gardner Syndrome', 'Salivary Gland Calculi', 'Ichthyosis Bullosa of Siemens', 'Mumps', 'Salivary Duct Calculi', 'Measles', 'Phyllodes Tumor', 'Neoplasms, Fibroepithelial', 'Nephroma, Mesoblastic', 'Nocturnal Paroxysmal Dystonia', 'Ergotism', 'Infectious Bovine Rhinotracheitis', 'Gangliosidoses', 'Embolism and Thrombosis', 'Radiation Injuries, Experimental', 'Periarthritis', 'Arthritis, Reactive', 'Aphonia', 'Lymphoma, Large-Cell, Immunoblastic', 'Basal Ganglia Hemorrhage', 'Sunstroke', 'Olivopontocerebellar Atrophies', 'Kashin-Beck Disease', 'Tuberculosis, Miliary', 'Microstomia', 'Ectodermal Dysplasia 1, Anhidrotic', 'Croup', 'Cystadenocarcinoma', 'Swayback', 'Torsion Abnormality', 'Salpingitis', 'Pasteurella Infections', 'Leukemia L1210', 'Spasms, Infantile', 'Ileitis', 'Abdominal Abscess', 'Histiocytosis, Sinus', 'Leukocyte Disorders', 'Immune Reconstitution Inflammatory Syndrome', 'Immunoblastic Lymphadenopathy', 'Mallory-Weiss Syndrome', 'Blast Crisis', 'Leukoedema, Oral', 'Cystadenocarcinoma, Papillary', 'Subacute Sclerosing Panencephalitis', 'Hyaline Membrane Disease', 'Visceral Prolapse', 'Mirizzi Syndrome', 'Dermatitis, Photoallergic', 'Pseudolymphoma', 'Purine-Pyrimidine Metabolism, Inborn Errors', 'Postgastrectomy Syndromes', 'Eye Hemorrhage', 'Vascular Headaches', 'Uterine Cervical Diseases', 'Musculoskeletal Abnormalities', 'Plague', 'Dermatitis, Occupational', 'Cementoma', 'Sertoli-Leydig Cell Tumor', 'Dendritic Cell Sarcoma, Interdigitating', 'Cocarcinogenesis', 'Herpes Genitalis', 'Idiopathic Hypersomnia', 'Neisseriaceae Infections', 'Meningitis, Escherichia coli', 'Anovulation', 'Neoplasms by Histologic Type', 'Transfusion Reaction', 'Choledochal Cyst', 'Neoplasms, Unknown Primary', 'Lymphangitis', 'Mixed Tumor, Malignant', 'Skull Fracture, Depressed', 'Scurvy', 'Hematoma, Subdural, Spinal', 'Anemia, Hemolytic, Congenital Nonspherocytic', 'Carcinoma, Giant Cell', 'Pericarditis, Tuberculous', 'Leukemia, Monocytic, Acute', 'Tooth Demineralization', 'Treponemal Infections', 'HELLP Syndrome', 'Periostitis', 'Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative', 'Panniculitis, Peritoneal', 'Histiocytosis', 'Zellweger Syndrome', 'Adenocarcinoma, Sebaceous', 'Anal Gland Neoplasms', 'Chromoblastomycosis', 'Porphyrias', 'Entamoebiasis', 'Favism', 'Vertebral Artery Dissection', 'Nasopharyngeal Carcinoma', 'Dermatitis, Toxicodendron', 'Spinal Curvatures', 'Elbow Tendinopathy', 'Noonan Syndrome', 'Lymphatic Vessel Tumors', 'Mannosidase Deficiency Diseases', 'Arachnodactyly', 'Staphylococcal Skin Infections', 'Anemia, Dyserythropoietic, Congenital', 'Tuberculosis, Cutaneous', 'Syphilis, Cardiovascular', 'Gestational Weight Gain', 'Sex Chromosome Disorders of Sex Development', 'Melanoma, Amelanotic', 'Hemangioma, Capillary', 'Cystadenoma', 'Leukemia, Mast-Cell', 'Carcinoma, Medullary', 'Maxillofacial Abnormalities', 'Hypersensitivity, Immediate', 'Chromosome Duplication', 'Epidermolysis Bullosa Simplex', 'Extravasation of Diagnostic and Therapeutic Materials', 'Sarcoma, Alveolar Soft Part', 'Choroid Neoplasms', 'Tracheal Stenosis', 'Skull Neoplasms', 'Spermatocele', 'Angiokeratoma', 'Vascular Fistula', 'Vaginal Fistula', 'Burkholderia Infections', 'Carcinoma, Ehrlich Tumor', 'Ape Diseases', 'Arthropathy, Neurogenic', 'Erythromelalgia', 'Mucopolysaccharidoses', 'Hemangiopericytoma', 'Dysostoses', 'Tuberculosis, Ocular', 'Parvoviridae Infections', 'Histiocytic Sarcoma', 'Adenomatosis, Pulmonary', 'Neoplasms, Hormone-Dependent', 'Uveal Neoplasms', 'Ureterolithiasis', 'Blepharophimosis', 'Bartter Syndrome', 'Causalgia', 'Hydranencephaly', 'Superior Mesenteric Artery Syndrome', 'Ectromelia', 'Neurofibroma, Plexiform', 'Basal Cell Nevus Syndrome', 'Rubinstein-Taybi Syndrome', 'Foot Deformities, Congenital', 'Mycobacterium Infections, Nontuberculous', 'Tetrasomy', 'Carcinoma, Lewis Lung', 'Donohue Syndrome', 'Mast-Cell Sarcoma', 'Proteus Syndrome', 'Slow Virus Diseases', 'Kleine-Levin Syndrome', 'Chondrodysplasia Punctata, Rhizomelic', "Ludwig's Angina", 'Factor V Deficiency', 'Nystagmus, Congenital', 'Klippel-Trenaunay-Weber Syndrome', 'Kasabach-Merritt Syndrome', 'Carotid Body Tumor', 'REM Sleep Parasomnias', 'Gastric Fistula', 'Adrenocortical Adenoma', 'Open Bite', 'Neoplasm Seeding', 'Carcinoma, Papillary, Follicular', 'Jaw Cysts', 'Eisenmenger Complex', 'Central Nervous System Fungal Infections', 'Bland White Garland Syndrome', 'Hyperekplexia', 'Echinococcosis, Hepatic', 'Gingivitis, Necrotizing Ulcerative', 'Apudoma', 'Rhabdomyoma', 'Chromosome Fragility', 'Optic Atrophies, Hereditary', 'Tyrosinemias', 'Erythroplasia', 'Campomelic Dysplasia', 'Cat Diseases', 'Rumination Syndrome', 'Endoleak', 'Pulmonary Adenomatosis, Ovine', 'Ephemeral Fever', 'Chagas Cardiomyopathy', 'Giant Cell Tumor of Bone', 'Syndactyly', 'Hemoperitoneum', 'Atypical Hemolytic Uremic Syndrome', 'Vascular Malformations', 'Leukemia, Myeloid, Accelerated Phase', 'Anemia, Myelophthisic', 'Sex Chromosome Aberrations', 'Intervertebral Disc Displacement', 'Hoarseness', 'Respiratory Tract Fistula', 'Leukemia, Megakaryoblastic, Acute', 'Incontinentia Pigmenti', 'Tracheobronchomalacia', 'Shellfish Poisoning', 'Odontogenic Cysts', 'Hydropneumothorax', 'Giant Cell Tumor of Tendon Sheath', 'Thecoma', 'Meningomyelocele', 'Bladder Exstrophy', 'Refsum Disease, Infantile', 'Cranial Nerve Neoplasms', 'Postcholecystectomy Syndrome', 'Hyperlysinemias', 'Rheumatoid Nodule', 'Hyper-IgM Immunodeficiency Syndrome, Type 1', 'Talipes Cavus', 'Anemia, Refractory, with Excess of Blasts', 'alpha-Mannosidosis', 'Granulomatosis, Orofacial', 'Chills', 'Hydrothorax', 'Pyonephrosis', 'Esophageal Atresia', 'Dumping Syndrome', 'Wounds, Gunshot', 'Refsum Disease', 'Ornithine Carbamoyltransferase Deficiency Disease', 'Stomach Rupture', 'Albinism, Ocular', 'Antithrombin III Deficiency', 'Hemangioendothelioma, Epithelioid', 'Synkinesis', 'Lymphatic Abnormalities', 'Solitary Kidney', 'Immunoproliferative Disorders', 'Liver Diseases, Parasitic', 'Abdomen, Acute', 'Wolman Disease', 'Uterine Cervical Dysplasia', 'Hemoglobin C Disease', 'Shock, Traumatic', 'Nevus, Epithelioid and Spindle Cell', 'Prurigo', 'Ototoxicity']
Pick a random node key, say AHR:
node = nodes['AHR']
print(type(node))
print(len(node))
<class 'list'>
1
So each node is a list of length 1. What’s in that?
type(node[0])
dict
Another dictionary. Let’s get the keys:
print(node[0].keys())
dict_keys(['entity', 'type', 'PMID', 'official full name', 'sentence', 'numbers of articles', 'JT', 'TA', 'IF', 'IF5', 'year', 'date', 'alias names', 'description', 'url', 'mutation position', 'mutation alleles', 'MeSH ID', 'relation', 'external links', 'aging biomarker', 'longevity biomarker'])
for k in node[0].keys():
print(f"{k}: {node[0][k]}")
entity: AHR
type: Gene
PMID: ['33923487', '30716515', '25777082', '33233417', '28633424', '32939877', '24106308', '31640697', '26790370', '25110076', '29102224', '32915475', '32183254', '23406155', '24495120', '18975255', '28057405', '27363826', '33669008', '15592584', '33866778', '23555298', '32965514', '23614742', '32414118', '26857571', '25186463', '30626868', '25680693', '28526404', '34685709', '33527709', '31001893', '33592460', '29908909', '35766906', '36159806', '17070097', '31391494']
official full name: aryl hydrocarbon receptor
sentence: [['The aryl hydrocarbon receptor (AhR) is a transcription factor deeply implicated in health and diseases.', 'Historically identified as a sensor of xenobiotics and mainly toxic substances, AhR has recently become an emerging pharmacological target in cancer, immunology, inflammatory conditions, and aging.', 'Multiple AhR ligands are recognized, with plant occurring flavonoids being the largest group of natural ligands of AhR in the human diet.', 'The biological implications of the modulatory effects of flavonoids on AhR could be highlighted from a toxicological and environmental concern and for the possible pharmacological applicability.', 'Similar to other AhR modulators, flavonoids commonly exhibit tissue, organ, and species-specific activities on AhR.', 'Flavones, flavonols, flavanones, and isoflavones are the main subclasses of flavonoids reported as AhR modulators.', 'Some of the structural features of these groups of flavonoids that could be influencing their AhR effects are herein summarized.', 'However, limited generalizations, as well as few outright structure-activity relationships can be suggested on the AhR agonism and/or antagonism caused by flavonoids.'], ['Our literature review confirmed that these chemicals may disturb thyroid hormones homeostasis, activate aryl hydrocarbon receptor (AhR), and induce oxidative stress, which in turn may initiate a chain of events resulting in impairment of cochlea and hearing loss.'], ['In this view point, we (i) summarize the existing evidence to support a role of environmental toxicants other than UVR in the pathogenesis of EILs, (ii) we argue that activation of aryl hydrocarbon receptor (AHR) signalling by UVR and environmental toxicants is critically involved in triggering and sustaining a crosstalk between melanocytes, keratinocytes and fibroblasts, which then causes the development and persistence of EILs in human skin, and (iii) we discuss clinical implications for the prevention and treatment of EILs resulting from this concept.'], ['Gene pathway analysis unveiled gene networks involved in the regulation of various cellular functions, including acute response to oxidative stress via up-regulation of antioxidative gene transcripts controlled by nuclear factor erythroid-2 related factor 2 (NRF2), and up-regulation of aryl hydrocarbon receptor-controlled detoxifying gene transcripts.'], ['This invitro model maintains a stable phenotype over multiple weeks in both 96- and 384-well formats, supports highly reproducible tissue-like architectures and models pharmacologically- and environmentally important hepatic receptor pathways (ie AhR, CAR, and PXR) analogous to primary human hepatocyte cultures.'], ['Beside activation of AHR-NRF2 pathway in CS-exposed HSE, our results suggested that mitochondrial functions were strongly impacted and oxidized lipids failed to be eliminated promoting skin barrier alteration.'], ['We found that AhR activity and protein levels in human retinal pigment epithelial (RPE) cells, cells vulnerable in AMD, decrease with age.'], ['GLK overexpression selectively promotes IL-17A transcription by inducing the AhR-RORgammat complex in T cells.'], ['The ubiquitously expressed aryl hydrocarbon receptor (AhR) induces drug metabolizing enzymes as well as regulators of cell growth, differentiation and apoptosis.', 'Certain AhR ligands promote atherosclerosis, an age-associated vascular disease.', 'Therefore, we investigated the role of AhR in vascular functionality and aging.', 'Ex vivo, AhR activation reduced the migratory capacity of primary human endothelial cells.', 'AhR overexpression as well as treatment with a receptor ligand, impaired eNOS activation and reduced S-NO content.', 'Furthermore, AhR expression in blood cells of healthy human volunteers positively correlated with vessel stiffness.', 'Thus, AhR seems to have a negative impact on vascular and organismal aging.', 'Finally, our data from human subjects suggest that AhR expression levels could serve as an additional, new predictor of vessel aging.'], ['We studied the effect of melatonin on gene mRNA for the AhR and Nrf2 signal pathways.'], ['FICZ is well known as a high-affinity ligand for aryl hydrocarbon receptor (AHR).', 'The actions of FICZ on the TGF-beta-mediated collagen I expression and nuclear translocation of pSmad2/3 were analyzed in the presence of selective AHR antagonists or in AHR-knockdown NHDFs.', 'The inhibitory actions of FICZ on the TGF-beta-mediated collagen I expression and nuclear translocation of pSmad2/3 were independent of AHR signaling.', 'Another endogenous AHR agonist, kynurenine, also inhibited the TGF-beta-mediated ACTA2 and collagen I upregulation in NHDFs in an AHR-independent manner; however, its effects were insignificant in comparison with those of FICZ.'], ['Immunofluorescence microscopy was used to determine if particulate matter caused activation of the aryl hydrocarbon receptor, and phosphorylation of histone H2AX, a known marker of double-strand DNA breaks.', 'Particulate matter was found to dose-dependently increase cellular viability, activate the aryl hydrocarbon receptor, increase double-strand DNA breaks, and increase the expression of MMP-1, MMP-3, and TGFbeta.'], ['On the other hand, it has been demonstrated that the aryl hydrocarbon receptor (AHR) participates in the inflammatory response.', "However, there is no information concerning the behavior and participation of AHR in the human aging brain or in Alzheimer's disease (AD).", 'We evaluated the expression of AHR in human hippocampal post-mortem tissue and its association with reactive astrocytes by immunohistochemistry.', 'The levels of AHR and glial fibrillar acid protein were higher in elder than in young post-mortem brain samples.', 'We found higher serum levels of AHR in AD patients than in the other participants.'], ['New molecular mechanisms linking sun and environmental factors to skin ageing have been identified: IR affects mitochondrial integrity and specific heat receptors also mediate some of its effects, tryptophan is a chromophore for UVB, and the aryl hydrocarbon receptor (AhR) is activated by light and xenobiotics to alter skin physiology.'], ['Owing, in part, to the ability of xenobiotic ligands to have persistent effects on the immune system in experimental animals, there has been much work to define a physiological role of the aryl hydrocarbon receptor (AhR) and its relationship to human disease.'], ['Expression levels of several oxidoreductase transcripts were strongly induced, most prominent CYP1A1, known to be regulated via the aryl hydrocarbon receptor pathway.'], ["RESULTS: Our candidate study found a significant association between SNP rs2066853 in exon 10 of the aryl hydrocarbon receptor gene AHR and crow's feet."], ['Mechanisms, which EDCs use to induce these skin disorders are complicated, and involve the interference of endogenous hormones and most importantly the activation of the aryl hydrocarbon receptor signal pathway.'], ['Examples include immunomodulation and changes in catecholamine production by histone deacetylase inhibition, anti-inflammatory effects through activity on the aryl hydrocarbon receptor and involvement in protein misfolding.'], ['In this article, studies which provide evidence as to the possible mechanisms by which the aryl hydrocarbon receptor (AhR) acts in this capacity (i.e.', 'Based on findings that the AhR is evolutionarily conserved and necessary for normal fertility, we suggest that the AhR has not only a pathological but also a physiological role in the process of aging.', 'Studies of realistic lifelong AhR activation by dioxins on the hypothalamic-pituitary-ovarian axis and its impact on the transition to reproductive senescence in the aging female are a previously neglected area of research that warrants further consideration.'], ['BACKGROUND: High circulating levels of dioxins and dioxin-like chemicals, acting via the aryl hydrocarbon receptor (AhR), have previously been linked to diabetes.', 'We now investigated whether the serum AhR ligands (AhRL) were higher in subjects with metabolic syndrome (MetS) and in subjects who had developed a worsened glucose tolerance over time.', 'CONCLUSION: These findings support a large body of epidemiologic evidence that exposure to AhR transactivating substances, such as dioxins and dioxin-like chemicals, might be involved in the pathogenesis of MetS and diabetes development.'], ['Differential analysis found networks mimicking developmental processes (activated all-trans-retinoic acid (ATRA, Z-score = 4.5; P = 6 x 10(-13)) and inhibited aryl-hydrocarbon receptor signaling (AhR, Z-score = -2.3; P = 3 x 10(-7))) with RET.', 'Intriguingly, as ATRA and AhR gene-sets were also a feature of endurance exercise training (EET), they appear to represent "generic" physical activity responsive gene-networks.'], ['Aryl hydrocarbon receptor (AHR) is a cytoplasmic ligand-activated transcription factor involved in multiple cellular processes.', 'Tryptophan metabolites as ligands can activate AHR signaling in various diseases such as inflammation, oxidative stress injury, cancer, aging-related diseases, cardiovascular diseases (CVD), and chronic kidney diseases (CKD).', 'Accumulated uremic toxins in the body fluids of CKD patients activate AHR and affect disease progression.'], ['Tobacco smoke contains more than 3800 constituents, including numerous water-insoluble polycyclic aromatic hydrocarbons (PAHs) that trigger aryl hydrocarbon receptor (AhR) signalling pathways.', 'To clarify the involvement of the AhR pathway, we used a stable AhR-knockdown HaCaT cell line.', 'AhR knockdown abolished the increased transcription of the AhR-dependent genes CYP1A1/CYP1B1 and MMP-1 induced by either of the tobacco smoke extracts.', 'Furthermore, the tobacco smoke extracts induced 7-ethoxyresorufin-O-deethylase activity, which was almost completely abolished by AhR knockdown.', 'Likewise, treating fibroblasts with AhR pathway inhibitors, that is, the flavonoids 3-methoxy-4-nitroflavone and alpha-naphthoflavone, blocked the expression of CYP1B1 and MMP-1.', 'These findings suggest that the tobacco smoke extracts induce MMP-1 expression in human fibroblasts and keratinocytes via activation of the AhR pathway.', 'Thus, the AhR pathway may be pathogenetically involved in extrinsic skin ageing.'], ['We found that resveratrol inhibited PM-induced aryl hydrocarbon receptor activation and reactive oxygen species formation in keratinocytes.'], ['Finally, kynurenines represent known ligands of the mammalian aryl hydrocarbon receptor (AHR), and UPEC infection of Ahr(-/-)mice recapitulated the derepressed PMN recruitment observed previously in Ido1(-/-)mice.'], ['Consistent with our in vivo observations, AhR knock-down was sufficient to increase choroidal endothelial cell migration and tube formation in vitro.', 'Moreover, AhR knock-down caused an increase in collagen type IV production and secretion in both retinal pigment epithelial (RPE) and choroidal endothelial cell cultures, increased expression of angiogenic and inflammatory molecules, including vascular endothelial growth factor A (VEGFA) and chemokine (C-C motif) ligand 2 (CCL2) in RPE cells, and increased expression of secreted phosphoprotein 1 (SPP1) and transforming growth factor-beta1 (TGFbeta1) in choroidal endothelial cells.', 'Collectively, our findings identify AhR as a regulator of multiple pathogenic pathways in experimentally induced choroidal neovascularization, findings that are consistent with a possible role of AhR in wet AMD.'], ['We demonstrate that UroA and UAS03 exert their barrier functions through activation of aryl hydrocarbon receptor (AhR)- nuclear factor erythroid 2-related factor 2 (Nrf2)-dependent pathways to upregulate epithelial tight junction proteins.'], ['Because some phytochemicals exert their antioxidant activity by activating aryl hydrocarbon receptor (AhR), leading to subsequent induction of the antioxidant pathway including nuclear factor E2-related factor 2 (Nrf2) and NAD(P)H: quinone oxidoreductase 1 (Nqo1), we investigated whether Cyn also activates the AhR-Nrf2-Nqo1 pathway.', 'Cyn indeed induced the activation (nuclear translocation) of AhR, leading to nuclear translocation of Nrf2 and dose-dependent upregulation of Nrf2 and Nqo1 mRNAs in human keratinocytes.', 'The Cyn-induced AhR-Nrf2-Nqo1 activation was AhR- and Nrf2-dependent, as demonstrated by the observation that it was absent in keratinocytes transfected by siRNA against either AhR or Nrf2.'], ['Principally, SRM1649b facilitated Aryl hydrocarbon receptor (AhR) translocated into nucleus, subsequently activated ERK/MAPK signaling pathway, and upregulated aging-related genes expression.', 'Most important, we found that AhR antagonist efficiently revert the aging of skin cells.'], ['In recent years, aryl hydrocarbon receptor (AhR), a ligand-activated transcription factor, has been considered to be involved in aging phenotypes across several species.', 'Interestingly, many studies have implicated AhR signaling pathways in the aging process and longevity across several species.', 'This review provides an overview of the impact of AhR pathways on various aging hallmarks in the brain and the implications for AhR signaling as a mechanism in regulating aging-related diseases of the brain.', 'We also explore how the nature of AhR ligands determines the outcomes of several signaling pathways in brain aging processes.'], ['Also, damaging the skin barrier seems to be closely related to the increased production of reactive oxygen species (ROS), induction of oxidative stress, activation of aryl hydrocarbon receptor (AhR), and inflammatory cytokines.'], ['Cytotoxic effects, activation of AhR, phosphorylation of p38 kinase and ROS generation were examined in PM-treated HaCaT cells.'], ['oxidative potential, inflammatory potential, aryl hydrocarbon receptor (AhR) agonist activity, and DNA-damage, were measured.', 'The AhR activity was dominated by open burning, followed by vehicle exhaust and NapSOA.'], ['We investigated (i) incidence and prevalence of eczema in elderly women, (ii) its association with long-term TRAP exposure and (iii) the effect modification by AHR polymorphism rs2066853.'], ['Expression of four genes (aryl hydrocarbon receptor [AHR], CD27, CD28, and interleukin-2 receptor subunit alpha [IL2RA; CD25]) in T cells was associated with frailty, independent of age.'], ['Here, we review the elements that affect how tryptophan metabolism is regulated, including inflammation and stress, exercise, vitamins, minerals, diet and gut microbes, glucocorticoids, and aging, as well as the downstream regulatory effects of tryptophan metabolism, including the regulation of glutamate (Glu), immunity, G-protein coupled receptor 35 (Gpr35), nicotinic acetylcholine receptor (nAChR), aryl hydrocarbon receptor (AhR), and dopamine (DA).'], ['The aryl hydrocarbon receptor is a ligand activated transcription factor which regulates biological responses to a variety of environmental pollutants, such as dioxin (2,3,7,8-tetrachlorodibenzo-p-dioxin, TCDD) and cigarette smoke.', 'A role of the AHR in mediating these events is indicated by the observations that the TCDD and CSC-induced decreases in p15(INK4b), p16(INK4a) and p53 expression was accompanied by a corresponding increase in the expression levels of the AHR target gene, CYP1A1.', "In addition, cotreatment with the AHR antagonist, 3'-methoxy-4'-nitroflavone (MNF) blocked the effects of TCDD and CSC on p53 and CYP1A1 expression."], ['The aryl hydrocarbon receptor (AHR) is expressed by immune cells and binds numerous xenobiotics.', 'Given that coordinated shifts in T cell metabolism are essential for T cell responses to numerous challenges, and that humans are constantly exposed to many different types of AHR ligands, this has far-reaching implications for how AHR signaling, particularly during development, durably influences T cell mediated immune responses across the lifespan.']]
numbers of articles: 39
JT: ['Molecules (Basel, Switzerland)', 'Environmental research', 'Experimental dermatology', 'International journal of molecular sciences', 'Toxicological sciences : an official journal of the Society of Toxicology', 'Experimental dermatology', 'Proceedings of the National Academy of Sciences of the United States of America', 'Journal of biomedical science', 'Scientific reports', 'Bulletin of experimental biology and medicine', 'Journal of dermatological science', 'FASEB journal : official publication of the Federation of American Societies for Experimental Biology', 'International journal of molecular sciences', 'International journal of cosmetic science', 'Annals of the New York Academy of Sciences', 'Planta medica', 'Journal of dermatological science', 'Reviews in endocrine & metabolic disorders', 'Nutrients', 'Reproductive biology', 'Endocrinology and metabolism (Seoul, Korea)', 'PLoS genetics', 'Cellular and molecular life sciences : CMLS', 'Experimental dermatology', 'International journal of molecular sciences', 'Infection and immunity', 'The Journal of pathology', 'Nature communications', 'Toxicology letters', 'Biochemical and biophysical research communications', 'Cells', 'Dermatologic therapy', 'Experimental dermatology', 'The Science of the total environment', 'International journal of hygiene and environmental health', 'British journal of haematology', 'Frontiers in immunology', 'Oral oncology', 'Scientific reports']
TA: ['Molecules', 'Environ Res', 'Exp Dermatol', 'Int J Mol Sci', 'Toxicol Sci', 'Exp Dermatol', 'Proc Natl Acad Sci U S A', 'J Biomed Sci', 'Sci Rep', 'Bull Exp Biol Med', 'J Dermatol Sci', 'FASEB J', 'Int J Mol Sci', 'Int J Cosmet Sci', 'Ann N Y Acad Sci', 'Planta Med', 'J Dermatol Sci', 'Rev Endocr Metab Disord', 'Nutrients', 'Reprod Biol', 'Endocrinol Metab (Seoul)', 'PLoS Genet', 'Cell Mol Life Sci', 'Exp Dermatol', 'Int J Mol Sci', 'Infect Immun', 'J Pathol', 'Nat Commun', 'Toxicol Lett', 'Biochem Biophys Res Commun', 'Cells', 'Dermatol Ther', 'Exp Dermatol', 'Sci Total Environ', 'Int J Hyg Environ Health', 'Br J Haematol', 'Front Immunol', 'Oral Oncol', 'Sci Rep']
IF: [0.0, 8.3, 3.6, 5.6, 3.8, 3.6, 11.1, 11.0, 0.0, 0.7, 0.0, 0.0, 5.6, 2.3, 0.0, 2.7, 0.0, 8.2, 5.9, 2.1, 0.0, 0.0, 8.0, 3.6, 5.6, 3.1, 7.3, 16.6, 3.5, 3.1, 6.0, 3.6, 3.6, 9.8, 6.0, 6.5, 7.3, 0.0, 0.0]
IF5: [0.0, 8.2, 3.7, 6.2, 4.3, 3.7, 12.0, 10.9, 0.0, 0.7, 0.0, 0.0, 6.2, 2.6, 0.0, 3.2, 0.0, 9.3, 6.6, 2.2, 0.0, 0.0, 8.7, 3.7, 6.2, 3.2, 7.5, 17.0, 3.8, 3.2, 6.7, 3.4, 3.7, 9.6, 6.2, 6.2, 8.0, 0.0, 0.0]
year: [2021, 2019, 2015, 2020, 2017, 2021, 2013, 2019, 2016, 2014, 2018, 2020, 2020, 2013, 2014, 2008, 2017, 2016, 2021, 2004, 2021, 2013, 2021, 2013, 2020, 2016, 2015, 2019, 2015, 2017, 2021, 2021, 2019, 2021, 2018, 2022, 2022, 2007, 2019]
date: [20210416, 20190401, 20150601, 20201121, 20170901, 20211101, 20131022, 20191022, 20160121, 20140801, 20180101, 20201101, 20200314, 20130601, 20140301, 20081101, 20170401, 20160901, 20210225, 20041101, 20210401, 20130301, 20210201, 20130501, 20200513, 20160401, 20150101, 20190109, 20150416, 20170701, 20211013, 20210301, 20190701, 20210615, 20180701, 20221001, 20220101, 20070801, 20190807]
alias names: RP85; bHLHe76
description: The protein encoded by this gene is a ligand-activated helix-loop-helix transcription factor involved in the regulation of biological responses to planar aromatic hydrocarbons.
url: https://www.ncbi.nlm.nih.gov/gene/196
mutation position:
mutation alleles:
MeSH ID:
relation: True
external links: [{'NCBI': {'NCBI_URL': 'https://www.ncbi.nlm.nih.gov/gene/196', 'NCBI_ID': '196'}}]
aging biomarker: True
longevity biomarker: False
So what does this tell us? These are annotations of the node that tell us:
The name of the entity (node)
What the type of the node is (a gene, in this case)
The official full name and alias names of the entity.
A URL to the official record of the entity.
A description of the entity.
Some entries tell us about the research papers that include information about the entity:
The number of articles that mention this entity
The PMID (pubmed identity) of the article that were used to get information about the entity. You can enter these numbers at https://pubmed.ncbi.nlm.nih.gov to get the papers themselves.
A sentence containing the entity name from each of the articles.
The JT (journal title) TA (journal title abbreviation) of each article.
The IF (impact factor) and IF5 (five year impact factor) of each of the journals.
The year and date each of the articles was published.
Information about mutations: mutuation position and mutation alleles.
Some external links and the MeSH ID for the Medical Subject Headings database.
Whether the entity is an aging biomarker or a longenvity biomarker.
Let’s now look at one of the edges:
edgekeys = list(edges.keys())
edge = edges[edgekeys[50000]]
for k in edge.keys():
print(f"{k}: {edge[k]}")
source entity: Blindness
relationship: characterized
target entity: Neurodegenerative Diseases
sentence: ['Advanced age-related macular degeneration (AMD), the leading cause of blindness among people over 50 years of age, is characterized by atrophic neurodegeneration or pathologic angiogenesis.']
source: ['blindness']
target: ['atrophic neurodegeneration']
source type: ['Disease']
target type: ['Disease']
PMID: ['30185655']
DP: ['2018 Sep 6']
date: [20180906]
TI: ['Impaired monocyte cholesterol clearance initiates age-related retinal degeneration and vision loss.']
TA: ['JCI Insight']
IF: [8.0]
IF5: [8.5]
method: ['shortest path']
Perhaps the two key properties of the edge are the
source entity and target entity which specify the entity property of the nodes that the edge connects. Let us check that these exist and see what they are:
source_node = nodes[edge['source entity']]
for k in source_node[0].keys():
print(f"{k}: {source_node[0][k]}")
entity: Blindness
type: Disease
PMID: ['35743984', '35742861', '35259614', '35239183', '35195542', '35094227', '34794419', '34782457', '34721402', '34695546', '34605605', '34572041', '34475488', '34426259', '34397018', '34388669', '34338961', '34313391', '34310874', '34298993', '34239945', '34201393', '34127677', '34088286', '34079244', '34022179', '33926642', '33917258', '33848003', '33826856', '33769566', '33751148', '33607015', '33591358', '33468208', '33375833', '33371261', '33362238', '33355716', '33341602', '33315052', '33309690', '33276809', '33275949', '33271081', '33255657', '33172148', '33151944', '33129920', '33079232', '33066702', '33053313', '33031188', '32964799', '32956341', '32924282', '32831993', '32770042', '32759996', '32737203', '32691052', '32666702', '32664778', '32634010', '32446621', '32443320', '32434914', '32348512', '32318056', '32153203', '32116056', '32017889', '31994475', '31813309', '31775013', '33438587', '31712067', '31653841', '31614715', '31611107', '31586989', '31557880', 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'27490232', '27466183', '27381593', '27373973', '27349759', '27347642', '27288727', '27213766', '27197072', '27156261', '27155572', '27150090', '27130547', '27109004', '27108144', '27031563', '27029644', '27013848', '26990907', '26959126', '26936827', '26861912', '26857947', '26854823', '26843396', '26838669', '26823705', '26801916', '26794210', '26771984', '26692726', '26691988', '26626701', '26618454', '26545238', '26508081', '26456751', '26443605', '26443334', '26432918', '26427395', '26420424', '26394754', '26391448', '26369397', '26369358', '26319346', '26311237', '26302445', '26284546', '26278693', '26260587', '26258992', '26239828', '26198091', '26119516', '26113213', '26054436', '25974263', '25957278', '25915531', '25904772', '25884924', '25868986', '25827171', '25812482', '25714363', '25675254', '25603915', '25543336', '25446438', '25411476', '25395684', '25260885', '25200490', '25069775', '25058422', '25046669', '25027944', '25001000', '24949869', '24879089', '24819336', '24809393', '24780906', '24748782', '24670995', '24665132', '24518755', '24518073', '24447403', '24400641', '24369445', '24346621', '24340512', '24335067', '24335068', '24303860', '24291520', '24282482', '24169698', '24160756', '24144491', '24130789', '24098751', '24083358', '24053669', '23865606', '23837226', '23800298', '23763217', '23700902', '23601964', '23586972', '23585288', '23493534', '23362846', '23341606', '23339719', '23301576', '23284695', '23209669', '23209345', '23185481', '23177625', '23029250', '22961342', '22957525', '22833762', '22794258', '22773900', '22678502', '22595906', '22511635', '22503690', '22469746', '22465421', '22415565', '22410570', '22378827', '22357958', '22273353', '22074583', '21984460', '21984457', '21978083', '21902783', '21898270', '21844367', '21816153', '21805812', '21804464', '21770952', '21750722', '21746733', '21702873', '21609511', '21552568', '21480547', '21437562', '21422745', '21402586', '21386905', '21261412', '21175380', '21107261', '21071745', '21052933', '21048433', '21042291', '20950366', '20879805', '20868255', '20858511', '20703916', '20691201', '20642340', '20565311', '20565250', '20524453', '20471686', '20353264', '20300521', '20206286', '20153746', '20150599', '20107178', '20100100', '20042177', '20030429', '19995201', '19899991', '19890428', '19765487', '19751815', '19740356', '19719805', '19710611', '21141003', '19587596', '19580816', '19567368', '19503764', '19494642', '19409449', '19402586', '19234096', '19222248', '19220938', '19216553', '19191183', '19190732', '19120547', '19111253', '19065428', '19051127', '18983632', '18948096', '18853278', '18850470', '18817863', '18801361', '18772479', '18726954', '18711452', '18667008', '18596911', '18464798', '18448796', '18388961', '18372860', '18326047', '18162041', '18085171', '18026851', '18003870', '17967453', '17967937', '17940554', '17804991', '17572499', '17554167', '17488857', '17363887', '17337062', '17325140', '17322604', '17313944', '17240813', '19450351', '17191188', '17148042', '17101537', '17065483', '17054134', '17031284', '16954704', '16952116', '16949442', '16877387', '16877280', '16816528', '16799233', '16787919', '16764653', '16712466', '16710702', '16632235', '16596316', '16550811', '16531676', '16485860', '16466594', '16374043', '16358134', '16326027', '16310784', '16259644', '16255690', '16226514', '16107273', '16084819', '16053555', '16024844', '16005406', '15954061', '15917104', '15870199', '15845346', '15838737', '15834082', '15790875', '15632016', '15589692', '15185415', '15180834', '15174955', '15152418', '15132296', '15123717', '15115112', '15078664', '15051748', '15036570', '14996628', '19785217', '14964795', '14715066', '14715058', '14711715', '14677729', '14644195', '14628967', '14626365', '14620383', '14560864', '14550396', '12882822', '12831291', '12799231', '12786766', '12786771', '12776220', '12671806', '12598445', '12537645', '12528915', '12408271', '12386068', '12185115', '12099691', '12084753', 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'8431837', '1512393', '1480401', '1639395', '1515797', '1419249', '1683023', '1794004', '2297030', '2255924', '2187687', '2263897', '2788109', '2757994', '3684237', '3552598', '3430853', '3322949', '2837061', '2443394', '4001042', '6706254', '6661922', '6581128', '7112182', '6648586', '6223389', '7324880', '7125439', '7105792', '6992550', '493186', '391520', '830713', '65246', '36439688', '36358978', '36343937', '36321128', '36262710', '36261438', '36200281', '35910837', '35805159', '35690384', '35665540', '35314773', '36835325', '36633858', '36572168', '36565712', '36543693', '36510173', '36130856', '35396573', '34981287', '34670454', '36964267', '36893949', '36808309', '36690073', '35670227', '23312281', '31149787', '16713954', '10688395', '9135934', '25664420', '19100677', '16276278', '4045484', '34569353', '29936867', '23341635', '11285664', '31261189', '1893509', '33581561', '29521211', '23531963', '35636634', '21868404', '17111761', '17060846', '33882813', '31624024', '21191272', '21076360', '15520971', '33406151', '9503868', '37700068', '35216586', '7786707', '28290467', '26315699', '25523434', '18711268', '36070354', '26068610', '12076405', '10672449', '20976099', '17274490', '33845978', '19290039', '9134463', '26084572', '24282228', '3034535', '26093354', '11371479', '8358940', '32971140', '23585309', '21443578', '35459692', '26899286', '23271595', '36433920', '18388842', '8157088', '29343291', '28972029', '26900829', '26245171', '14531650', '31111484', '11045657', '10093310', '31282275', '17197522', '3668564', '25371590', '24835856', '20196930', '19834322', '37910517', '37889504']
official full name: None
sentence: [['It is an opacity of the lens that worsens vision and can lead to blindness.'], ['It is the leading cause of blindness, with no cure.', 'These results indicate that PBM shows great potential to cure RPE degeneration to help patients with blindness.'], ['BACKGROUND AND OBJECTIVE: Age-related macular degeneration (AMD) is the most common cause of blindness in developed countries, especially in people over 60 years of age.'], ['Age-related macular degeneration (AMD) is the leading cause of blindness in the aging population.'], ['Untreated, it can lead to irreversible blindness.'], ['BACKGROUND AND OBJECTIVE: Age-related macular degeneration (AMD) is one of the most common reasons for blindness in the world today.'], ['BACKGROUND: Nearly 1.9% of global blindness is caused by glaucoma and this is sadly high in Africa which is around 15% and In Ethiopia, glaucoma is responsible for 5.2% of blindness.', 'It is also the fifth cause of blindness in Ethiopia.'], ['RPE cell death is the primary cause of blindness in the most prevalent incurable genetic and age-related human disorders, Stargardt disease and age-related macular degeneration (AMD), respectively.'], ['Background: Neovascular age-related macular degeneration (nAMD) is a leading cause of blindness in older people.'], ['Cataract and glaucoma are the major causes of severe visual loss and blindness in older adults.'], ['RESULTS: Most participants younger than 50 years had normal vision, while the cumulative risk of VI and blindness gradually increased after 50-59 years.', 'In participants aged >=50 years, older age, female sex, longer AL and increased severity of MM were risk factors for VI and blindness (all p < 0.05).'], ['Mainly in the elderly population, but also among younger people, such ocular pathologies are the cause of irreversible blindness or impaired, reduced vision.'], ['Visual impairment was classified into low vision and blindness.', 'The abnormal SPMSQ had significantly higher prevalence of low vision (44.52% vs 18.79%) and blindness (8.89% vs 0.93%) compared with normal SPMSQ.', 'The hazard ratios of abnormal SPMSQ in low vision and blindness were 2.34 (95% CI 2.17-2.52), and 5.13 (95% CI 4.50-5.85), after adjustment for confounders.'], ['HPL treatment may eventually represent a pragmatic and cost-effective alternative to corneal transplant to treat damages of the corneal endothelium which is a major cause of blindness worldwide.'], ['Increasing age (P < 0.001) and male sex (P = 0.01) were the factors significantly associated with blindness.', 'Conclusion: MSVI and blindness were common in our setting with glaucoma and cataract being the most prevalent associated diagnosis.'], ['Even in the presence of these provisions, PAS is fraught with multiple medical, ethical, moral and legal dilemmas and physicians as well as caregivers are quite heterogenous in their outlook.'], ['INTRODUCTION: Diabetic retinopathy is one of the most common causes of blindness in work-aging adults and develops in one third of diabetic patients.'], ['The nuclear factor-erythroid 2-related factor-2 (Nrf2), a major antioxidant transcription factor, is decreased in several age-related diseases including age-related macular degeneration (AMD), the most common cause of blindness among the elderly in western society.'], ['OBJECTIVES: Age-related macular degeneration is a leading cause of irreversible blindness in older people.'], ['Age-related macular degeneration (AMD) is a complex multifactorial neurodegenerative disease that constitutes the most common cause of irreversible blindness in the elderly in the developed countries.'], ['Age-related macular degeneration (AMD), a degenerative disease of the outer retina, is the leading cause of blindness among the elderly.'], ['Retinal diseases are the leading cause of irreversible blindness.'], ['Cataract is the leading cause of blindness among the elderly worldwide and cataract surgery is one of the most common operations performed in the United States.'], ['Specifically, the screening would reduce patients with primary angle closure suspect by 7.7%, primary angle closure by 8.8%, PACG by 16.7%, and visual blindness by 33.3%.'], ['Results: The standardized prevalence of mild visual impairment (<6/12 to >=6/18), moderate to severe visual impairment (MSVI) (<6/18 to >=3/60), and blindness (<3/60) in the better eye were 20.5%, 25.8%, and 3.4%, respectively.'], ['Age-related macular degeneration (AMD) is a progressive eye disease and the most common cause of blindness among the elderly.'], ['Age-related macular degeneration (AMD) is a leading cause of blindness.'], ['Cataracts are the major cause of blindness worldwide, largely resulting from aging and diabetes mellitus.'], ['Age-related macular degeneration (AMD) is a major cause of blindness in older individuals worldwide.'], ['Background: Cataracts are one of the leading causes of blindness in the world and disproportionately affect the elderly people and women.'], ['Age-related macular degeneration (AMD) is the most common cause of blindness in the Western world and is characterised in its latter stages by retinal cell death and neovascularisation and earlier stages with the loss of parainflammatory homeostasis.'], ['Age-related macular degeneration (AMD) is a chronic and progressive degenerative disease of the retina, which culminates in blindness and affects mainly the elderly population.'], ['FUNDING: Wellcome Trust, Commonwealth Scholarship Commission, National Institutes of Health, Research to Prevent Blindness, the Queen Elizabeth Diamond Jubilee Trust, Moorfields Eye Charity, National Institute for Health Research, Moorfields Biomedical Research Centre, Sightsavers, the Fred Hollows Foundation, the Seva Foundation, the British Council for the Prevention of Blindness, and Christian Blind Mission.'], ['Purpose: Refractive errors, particularly myopia, are common and a leading cause of blindness.'], ['BACKGROUND: Neovascular age-related macular degeneration (nAMD) is the most common cause of irreversible vision loss and blindness among the older people aged 50 and over.'], ['Low vision and blindness are major health issues affecting ageing population.'], ['Age-related macular degeneration (AMD) is the leading cause of blindness affecting the elderly in the Western world.'], ['RATIONALE: Age-related macular degeneration (AMD) is the most prevalent form of irreversible blindness in the developed world.'], ['Age-related macular degeneration (AMD) is a chronic, multifactorial disease and a leading cause of irreversible blindness in the elderly population in the Western Hemisphere.'], ['In the first experiment, we tested whether this effect transferred to visual exploration during a change detection task (under change blindness conditions), which was the case.'], ['Purpose: Age-related macular degeneration (AMD) is one of the leading causes of blindness among the elderly, and the exact pathogenesis of the AMD remains unclear.'], ['METHODS: We extracted data from the Global Vision Database (2017) and Global Burden of Disease Study (2017) to highlight temporal trends in global blindness since 1990, and provide a narrative overview of how COVID-19 may derail progress toward the goals of VISION 2020.', 'Despite these reductions, crude projections suggest that more than 700 million persons will experience MSVI or blindness by 2050, principally owing to our growing and ageing global population.'], ['The current gold standard of treatment for this worldwide blindness caused by corneal endothelial failure is the corneal transplantation using cadaveric donor corneas.'], ['We fitted hierarchical models to estimate prevalence (with 95% uncertainty intervals [UIs]) of moderate and severe vision impairment (MSVI; presenting visual acuity from <6/18 to 3/60) and blindness (<3/60 or less than 10 visual field around central fixation) by cause, age, region, and year.', 'Age-standardised prevalence of avoidable blindness decreased by -15 4% [-16 8 to -14 3], while avoidable MSVI showed no change (0 5% [-0 8 to 1 6]).', 'However, the number of cases increased for both avoidable blindness (10 8% [8 9 to 12 4]) and MSVI (31 5% [30 0 to 33 1]).', 'The leading global causes of blindness in those aged 50 years and older in 2020 were cataract (15 2 million cases [9% IU 12 7-18 0]), followed by glaucoma (3 6 million cases [2 8-4 4]), undercorrected refractive error (2 3 million cases [1 8-2 8]), age-related macular degeneration (1 8 million cases [1 3-2 4]), and diabetic retinopathy (0 86 million cases [0 59-1 23]).', 'INTERPRETATION: Results suggest eye care services contributed to the observed reduction of age-standardised rates of avoidable blindness but not of MSVI, and that the target in an ageing global population was not reached.'], ['FINDINGS: In 2019, the age-standardised prevalence was 2 57% (uncertainty interval [UI] 2 28-2 86) for moderate vision impairment, 0 25% (0 22-0 29) for severe vision impairment, and 0 48% (0 43-0 54) for blindness in China, which were all below the global average, but the prevalence of moderate and severe vision impairment had increased more rapidly than in other G20 countries from 1990 to 2019.', 'From 1990 to 2019, the number of people with moderate vision impairment increased by 133 67% (from 19 65 to 45 92 million), those with severe vision impairment increased by 147 14% (from 1 89 to 4 67 million), and those with blindness increased by 64 35% (from 5 29 to 8 69 million); in each case, 20 16% of the increase could be explained by population growth.', 'The contributions to these changes by population ageing were 87 22% for moderate vision impairment, 116 06% for severe vision impairment, and 99 22% for blindness, and the contributions by age-specific prevalence were 26 29% for moderate vision impairment, 10 91% for severe vision impairment, and -55 04% for blindness.', 'INTERPRETATION: Although a comprehensive national policy to prevent blindness is in place, public awareness of visual health needs improving, and reducing the prevalence of moderate and severe vision impairment should be prioritised in future work.'], ['Pathological neovascularization in the eye is a leading cause of blindness in all age groups from retinopathy of prematurity (ROP) in children to age-related macular degeneration (AMD) in the elderly.'], ['Age-related macular degeneration is an eye disease that is the main cause of legal blindness in the elderly in developed countries.'], ["Onchocerciasis also known as river blindness is a neglected tropical disease and the world's second-leading infectious cause of blindness in humans; it is caused by Onchocerca volvulus."], ['Age-related macular degeneration (AMD) is the third leading cause worldwide blindness that causes permanent central vision impairment in older people.'], ['Neovascular age-related macular degeneration (nAMD) is the leading cause of blindness in aging populations.'], ['Cataracts or clouding of the lens is the leading cause of blindness in the world.'], ['As the prevalence of age-related vision impairment continues to increase, it will become imperative to understand the unique needs of working-age and older adults with acquired vision impairment who pursue braille.Implications for REHABILITATIONThis study is one of the first to explore the experiences of working-age and older adults with acquired visual impairment who pursue braille rehabilitation training.Rehabilitation professionals must take into account prior learning and reading experiences which may shape the braille learning process.Family members require greater access to resources and support during the training process.There is a significant need for public education to address societal misconceptions about braille and blindness that can lead to a reluctance to use braille.Interactions with other braille users foster more empowering definitions of braille that align with the social model understanding of disability.'], ['PURPOSE: Late presentation of glaucoma often causes blindness.'], ['In Stage1, rural primary health workers approached all individuals aged >=60 years for app-based dementia screening in 12 villages in Hai district, Kilimanjaro Tanzania.In Stage 2, a stratified sub-sample were clinically-assessed for dementia blind to app screening score.'], ['INTRODUCTION: Age-related macular degeneration is the leading cause of blindness in older people in the world.'], ['AIM: Public subsidy of the oxycodone/naloxone controlled release (CR) combination in December 2011 expanded the overall market for oxycodone CR in the general public in Australia; we evaluate its impact in people with cancer.'], ['Age-related macular degeneration (AMD) is a leading cause of severe visual loss and irreversible blindness in the elderly population worldwide.'], ['VI categories included low vision (presenting visual acuity worse than 6/18 to 3/60) and blindness (presenting visual acuity worse than 3/60).'], ['Possible long-term complications of GCA include aneurysm and stenosis of vessels, even in patients with apparently clinically inactive disease; acute blindness is rare during glucocorticoid treatment.'], ['Strong evidence suggests that dysregulated lipid metabolism involving dysfunction of the retinal pigmented epithelium (RPE) underlies the pathogenesis of age-related macular degeneration (AMD), the leading cause of irreversible blindness in the elderly.'], ['Age-related macular degeneration (AMD) is a chronic, multifactorial disorder and a leading cause of blindness in the elderly.'], ['BACKGROUND: Age-related macular degeneration (AMD) is the leading cause of blindness in the elderly individuals.'], ['Crude prevalence of moderate/severe VI and blindness were both 2%.', 'Cataract was found in 73% of the HIV+s with blindness and in 63% of those with moderate/severe VI.'], ['VI was defined as presenting VA 6/18 and included moderate VI ( 6/18-6/60), severe VI ( 6/60 -3/60) and blindness ( 6/120).', 'The prevalence of VI and blindness was 63.6%.', 'Optical correction significantly reduced the prevalence of VI and blindness by 19.5% (p 0.05).', 'The main causes of non-refractive VI and blindness were cataract (54.5%), posterior segment disorders (25.5%) and corneal opacities (20%).', 'CONCLUSION: The prevalence of VI and blindness is high among residents in low-income old age homes living in Durban.', 'Refractive correction and surgical cataract intervention can significantly reduce the burden of VI and blindness among the elderly residents.'], ['Age-related macular degeneration (AMD) is the leading cause of blindness among the elderly.'], ['The overall prevalence of blindness and low vision were 1.5% and 8.2%.', 'The prevalence of blindness and low vision was higher among older individuals (P < .05) and lower (P < .05) among those with the highest education level.', 'Cataract, corneal opacity, and glaucoma were considered as the main causes of blindness, which accounted for 67.9%, 10.7%, and 7.1%, respectively.', 'Cataract, refractive error, and age-related macular degeneration were always considered as the leading causes of low vision, which accounted for 66%, 14.7%, and 5.8%, respectively.Cataract, corneal opacity, and glaucoma were the main causes of blindness and low vision in the population aged 50 years or more.', 'The prevalence of these diseases that causes blindness and low vision was higher than that reported in other studies.'], ['Age-related macular degeneration (AMD) is the leading cause of blindness in the elderly.', 'While the histopathology of the different disease stages is well characterized, the cause underlying the progression, from the early drusen stage to the advanced macular degeneration stage that leads to blindness, remains unknown.'], ['It is considered a clinical emergency because it can lead to irreversible blindness in around 20% of untreated cases.'], ['A common allele (402H) of the complement factor H (FH) gene is the major risk factor for age-related macular degeneration (AMD), the leading cause of blindness in the elderly population.'], ['INTRODUCTION: Age-related macular degeneration (AMD) is the most common cause of blindness among the elderly in the industrialized world.'], ['Introduction: Age-related Macular Degeneration (AMD), a retinal neurodegenerative disease is the most common cause of blindness among the elderly in developed countries.'], ['Age-related macular degeneration (AMD) is a universal leading cause for irreversible blindness in the elderly population.'], ["; Conclusion: Since the course of the ocular involvement in late-onset Behcet's disease is regarded to be relatively mild, it is noteworthy that our study revealed that blindness was noted in 10,5% and posterior uveitis and panuveitis were the most common uveal lesion."], ['The prevalence of bilateral blindness was 1.7% [95%CI: 1.1-2.4].', 'Cataract (43.3%) was the main cause of blindness, followed by glaucoma (30%), age-related macular degeneration (ARMD) (8.3%), other posterior segment diseases (6.7%) and non-trachomatous corneal opacities (5%).', 'The prevalence of blindness and visual impairment increased strongly with age.', 'The data suggest that an expansion of eye care services to reduce avoidable blindness is needed, as ageing will lead to an increase in older people at risk and a higher demand for eye care in the future.'], ['Giant cell arteritis is the most common systemic vasculitis in the elderly and is a potentially life-threatening ophthalmic emergency that can result in irreversible blindness.', 'Without treatment, second eye involvement may occur, resulting in bilateral blindness.'], ['Age-related macular degeneration (AMD) is known as a major cause of irreversible blindness in elderly adults.', 'In 2010, AMD involved 6.6% of all blindness cases around the world.'], ["METHODS: Population data were obtained from the Georgia Governor's Office of Planning and Budget, stratified by age and race and applied to the Prevent Blindness America eye disease prevalence values."], ['Genome-wide association studies (GWAS) have identified genetic variants associated with age-related macular degeneration (AMD), one of the leading causes of blindness in the elderly.'], ['Using national cross-sectional blindness surveys from Nigeria (2005-2007; n = 13,591) and Sri Lanka (2012-2014; n = 5779) we categorized women and men by marital status (married/not-married) and place of residence (urban/rural) concurrently.'], ['Symptomatic patients included amaurosis fugax (n = 3), stroke (n = 16), and transient ischemic attack (n = 25).'], ['Furthermore, the alternative to the reversible (and avoidable) side effects of rapamycin/everolimus are the irreversible (and inevitable) effects of aging: cancer, stroke, infarction, blindness and premature death.'], ['Diabetic retinopathy (DR), a sight-threatening neurovasculopathy, is the leading cause of irreversible blindness in the developed world.'], ['The secondary transfer task, before and after treadmill walking, involved sudden loss of balance in a lean-and-release protocol.'], ['Age-related macular degeneration (AMD) involves the loss of retinal pigment epithelium (RPE) and photoreceptors and is one of the leading causes of blindness in the elderly.'], ['Arm reactions induced by a sudden loss of balance can play an important role in preventing falls and protecting against injury.'], ['Age-related macular degeneration (AMD) is now one of the leading causes of blindness in the elderly population and oxidative stress-induced damage to retinal pigment epithelial (RPE) cells occurs as part of the pathogenesis of AMD.'], ['Age-related macular degeneration (AMD) is a major reason of blindness in the elderly.'], ['Background: Age-related macular degeneration (AMD) is a leading cause of blindness in the ageing population.'], ['The magnitude of cataract pathology is indeed significant as it is the principal cause of blindness worldwide.'], ['Here, we report an autopsy-verified patient with MM2-coritical-type sporadic Creutzfeldt-Jakob disease (MM2C-type sCJD) presenting cortical blindness during a course of glaucoma and age-related macular degeneration, and focus on the difficulties involved in early clinical diagnosis.'], ['Purpose: Age-related macular degeneration (AMD) is the leading cause of blindness in the elderly in Western Countries.'], ['Glaucoma is a common complex disease that leads to irreversible blindness worldwide.'], ['Compared to those with normal vision (visual acuity (VA) >=6/12, risk=9.7%), the 6-year mortality risk was higher among people with VI (<6/18 to >=6/60; risk=28.3%; risk ratio (RR) 1.75, 95% CI 1.28 to 2.40) or severe VI (SVI)/blindness (<6/60; risk=34.9%; RR 1.98, 95% CI 1.04 to 3.80).'], ['The health effects of IAP include acute respiratory infections, chronic obstructive pulmonary disease, pneumoconiosis, cataract and blindness, pulmonary tuberculosis, adverse effects to pregnancy, cancer, and cardiovascular and cerebrovascular disease.'], ['High prevalence of blindness coupled with low public awareness of eye diseases is a severe problem in Pakistan.', 'The majority (68.1%) of respondents were aware that blindness can be prevented and are least aware of age-related macular degradation (31.4%).', 'Among the general population of Pakistan, awareness about prevention of blindness and refractive error was optimum, while awareness of blindness causing eye conditions, like age-related macular degradation was low.'], ['It is the commonest cause of treatable blindness.'], ['Glaucoma is a multifactorial neurodegenerative disease that causes impaired vision and, in advanced cases, blindness.'], ['Age-related macular degeneration (AMD) is the main cause of irreversible blindness among the elderly and require early diagnosis to prevent vision loss, and careful treatment is essential.'], ['BACKGROUND AND OBJECTIVE: Age-related macular degeneration (AMD) is the leading cause of irreversible blindness among the elderly in developed countries.'], ['PURPOSE: With the aging population and the global diabetes epidemic, the prevalence of age-related macular degeneration (AMD) and diabetic macular edema (DME) diseases which are the leading causes of blindness is further increasing.'], ['Non-exudative age-related macular degeneration (NE-AMD) represents the leading cause of blindness in the elderly.'], ['A standardized questionnaire was used to identify factors associated with eye healthcare utilization, visual impairment and/or blindness.'], ['Importance: Vision impairment (VI), including blindness, affects hundreds of millions globally, and 90% of those with VI live in low- and middle-income countries.'], ["Death of the endothelial cells of the choroid may cause abnormal deposits including unesterified and esterified cholesterol beneath RPE cells and within Bruch's membrane that contribute to the progression of age-related macular degeneration (AMD), the most prevalent cause of blindness in older people."], ['Age-related macular degeneration (AMD) is the leading cause of blindness in the elderly in developed countries.'], ['LIMITATIONS: Possible limitations of this study are the presence of a single operator and the absence of blindness of the technique for both patient and assessor.'], ['Importance: Elevated intraocular pressure is a major risk factor for glaucoma, a leading cause of irreversible blindness worldwide.'], ['In conclusion, this novel study supports the merit of SHLP2 in the treatment of AMD, a primary retinal disease that is a leading cause of blindness among the elderly population in the United States as well as worldwide.'], ['CONCLUSIONS: Demographic, social and behavioral factors had impact on the structure and time trends of registered blindness among the Kuwaitis.'], ['Age-related macular degeneration (AMD) is an important cause of blindness.'], ['Nonpacking interventions were associated with an increased rate of blood transfusion (24.5% vs. 21.8%; P = .004), but no significant differences in rates of stroke, blindness, aspiration pneumonia, infectious pneumonia, thromboembolism, urinary/renal complications, pulmonary complications, cardiac complications, or in-hospital mortality.'], ['Advanced age-related macular degeneration (AMD), the leading cause of blindness among people over 50 years of age, is characterized by atrophic neurodegeneration or pathologic angiogenesis.'], ['Age-related macular degeneration (AMD) is a leading cause of blindness in people over 50 years of age in many developed countries.'], ['Diseases and disabilities such as dementia, spinal cord injuries or blindness make the user unable to drive the chair by his or her own.'], ['Background: Cataract is the second leading cause of visual impairment and the first of blindness globally.'], ['BACKGROUND: Population-based data on prevalence, causes of blindness and extent of ophthalmological coverage is required for efficient implementation and evaluation of ocular health programs.', 'Inter-regional and overall prevalence for blindness, severe VI and moderate VI were determined.', 'The age and gender-adjusted prevalence of blindness, severe visual impairment and moderate visual impairment were 1.2% (95% Confidence Interval: 1.0-1.4%), 1.0% (95%CI: 0.8-1.2%) and 5.9% (5.3-6.5%) respectively.', 'Untreated cataract (58.6%), diabetic retinopathy (10.4%) and glaucoma (6.6%) were the commonest causes of blindness.', 'Overall, 86.3% of the causes of blindness were avoidable.', 'Cataract surgical coverage (CSC) in persons for blindness, severe visual impairment and moderate visual impairment was 90%, 86% and 66% respectively.', 'CONCLUSION: Increased patient education and further expansion of ophthalmological services are required to reduce avoidable blindness even further in Malaysia.'], ['Macrophage aging is pathogenic in numerous diseases, including age-related macular degeneration (AMD), a leading cause of blindness in older adults.'], ['Worldwide, neovascular age-related macular degeneration (nAMD) is one of the most common causes of blindness in the elderly.'], ['The incidence for legal blindness was 2.3/100 000.'], ['The lower prevalence of glaucoma visits in regions farther away from ophthalmologist offices may result in delayed detection and blindness in this population.'], ['Macrophage aging is pathogenic in diseases of the elderly, including age-related macular degeneration (AMD), a leading cause of blindness in older adults.'], ['These properties have led to the hypothesis that carotenoids may protect against the development of age-related macular degeneration (AMD), the most common cause of blindness in the aged population >60 years old.'], ['BACKGROUND: Age-related macular degeneration (AMD) is a leading cause of blindness among the elderly characterized by retinal pigment epithelium (RPE) degeneration with accumulation of abnormal intracellular deposits (lipofuscin) and photoreceptor death.'], ['Here, we present, to the best of our knowledge, the first case of Werner syndrome with corneal blindness due to bilateral primary bullous keratopathy.', 'Our patient with Werner syndrome had primary bilateral bullous keratopathy and bilateral corneal blindness for 10 years and was eventually rehabilitated by corneal transplant.', 'Hence, this case highlights the importance of early referral of such patients to the ophthalmologist for prompt diagnosis and early treatment so that blindness could be avoided.'], ['Retinal prostheses have been developed to fight blindness in people affected by outer retinal layer dystrophies.'], ['Cataract is the leading cause of blindness with an estimated 16 million people affected worldwide.'], ['Pathologies affecting the optic nerve and the retina are one of the major causes of blindness.'], ['Background: Age-related macular degeneration (AMD) is the third most common cause of blindness, and the fourth leading cause of visual impairment worldwide, but little is known about the burden of this disease in the most populous country-China.'], ['Background: Glaucoma, the second leading cause of blindness, affects approximately 64.3 million individuals worldwide.'], ['RATIONALE: Age-related macular degeneration (AMD) is one of the leading causes of blindness among the elderly.'], ['Intra-arterial injections without sequelae and those resulting in blindness or necrosis were considered severe complications.', 'Among FDA-reported complications, blindness was significantly associated with dorsal nasal injections (P < .001).', 'Vascular compromise with and without sequela of dermal necrosis and blindness were significantly associated with Radiesse injections P < .001.', 'More serious events include vascular compromise, resulting in necrosis and blindness; these events are also raised in cases involving litigation.'], ['Purpose: Age-related nuclear cataract is the opacification of the clear ocular lens due to oxidative damage as we age, and is the leading cause of blindness in the world.'], ['BACKGROUND: Open Angle Glaucoma (POAG) is the leading causes of irreversible blindness worldwide.'], ['A chronic low-level inflammation contributes to the pathogenesis of age-related macular degeneration (AMD), the most common cause of blindness in the elderly in Western countries.'], ['Age-related macular degeneration (AMD) is the leading cause of irreversible vision loss and blindness in developed nations.'], ['INTRODUCTION: In Denmark, age-related macular degeneration (AMD) is the most common cause of blindness.'], ['Age Related Macular Degeneration (AMD) is the third leading cause of blindness and the first one in the elderly.', 'AMD usually causes central blindness due to loss of photoreceptor cell .'], ["AREAS COVERED: This review covers Leber's congenital amaurosis, choroideremia, retinitis pigmentosa, Usher syndrome, Stargardt disease, Leber's hereditary optic neuropathy, Achromatopsia, and X-linked retinoschisis."], ['Importance: Age-related macular degeneration (AMD) is a leading cause of irreversible blindness among the elderly population globally.'], ['PURPOSE: Age-related macular degeneration (AMD) is an eye disease causing blindness in the elderly.'], ['BACKGROUND: Lutein and zeaxanthin are suggested micronutrient supplements to prevent the progression of age-related macular degeneration (AMD), a leading cause of blindness worldwide.'], ['BACKGROUND: Raising public awareness and knowledge about glaucoma is a key for early case identification and prevention of blindness.'], ["Corneal endothelial cells play a critical role in maintaining corneal transparency and dysfunction of these cells caused by aging, diseases (such as Fuch's dystrophy), injury or surgical trauma, which can lead to corneal edema and blindness."], ['We fitted hierarchical models to estimate the prevalence (by age, country, and sex), in 2015, of mild visual impairment (presenting visual acuity worse than 6/12 to 6/18 inclusive), moderate to severe visual impairment (presenting visual acuity worse than 6/18 to 3/60 inclusive), blindness (presenting visual acuity worse than 3/60), and functional presbyopia (defined as presenting near vision worse than N6 or N8 at 40 cm when best-corrected distance visual acuity was better than 6/12).', "INTERPRETATION: There is an ongoing reduction in the age-standardised prevalence of blindness and visual impairment, yet the growth and ageing of the world's population is causing a substantial increase in number of people affected."], ['Age-related macular degeneration (AMD) is a common cause of irreversible blindness in the elderly in the western world.'], ['Since the circadian system regulates many behavioral and physiological processes, its disruption by external (shift-work, jet-lag) or internal desynchronization (blindness, aging) causes many different health problems.'], ['PURPOSE: Age-related macular degeneration (AMD) is one of the leading causes of blindness in the elderly population.'], ['Glaucoma is the most common optic neuropathy in humans and the leading cause of irreversible blindness worldwide.'], ['Importance: Cataract, one of the most frequent causes of blindness in developed countries, is strongly associated with aging.'], ['Age-related macular degeneration (AMD) is a leading cause of blindness in the elderly.'], ['Corneal blindness is a major cause of blindness in the world and corneal transplantation is the only widely accepted treatment to restore sight in these eyes.'], ['Age-related macular degeneration (AMD), the leading cause of blindness in the elderly, is a complex disease that results from multiple genetic and environmental factors.'], ['Additionally, a close link between the thinning of the retinal nerve fiber (RNFL) and AD patients has been described, while it has been proposed that AD patients suffer from a non-specific type of color blindness (Pache et al., 2003).'], ['Glaucoma is the most common cause of irreversible blindness worldwide.'], ['Age-related macular degeneration (AMD) is the most frequent cause of blindness in the elderly.'], ['Age-related macular degeneration (AMD) is a major cause of blindness in the elderly population.'], ['The other, age-related macular degeneration, is the most common form of blindness in the elderly.'], ['Cumulative incidence of VI and blindness, and factors associated with these outcomes, were estimated.', 'Using WHO definitions, the 6-year cumulative incidence of VI was 11.9% (95%CI [confidence interval]: 10.3-13.8%) and blindness was 1.51% (95%CI: 1.0-2.2%); using the US classification, the cumulative incidence of blindness was 2.70% (95%CI: 1.8-3.2%).', 'Conclusions: The incidence of VI and blindness in this older Kenyan population was considerably higher than in comparable studies worldwide.'], ['Purpose: Age-related macular degeneration (AMD) commonly causes blindness in the elderly.'], ['PURPOSE: Adaptation to blindness can lead to the enhancement of the attentional capacities and working memory in young people.'], ['CONCLUSIONS: Discussions around the applicability of HealthCoin for breakthrough therapies on the horizon, such as gene therapies for blindness and hemophilia B, and the feasibility of instituting such payments through new legislations or demonstration projects could be of great value.'], ['Cataract is the most common cause of blindness and a major cause of visual impairment worldwide.'], ['RESEARCH DESIGN AND METHODS: The meta-analysis of published population studies from 1990 to 2012 for the Global Burden of Disease Study 2010 (GBD) yielded estimated global regional trends in DR among other causes of moderate and severe vision impairment (MSVI; presenting visual acuity <6/18, >=3/60) and blindness (presenting visual acuity <3/60).', 'DR accounted for 2.6% of all blindness in 2010 and 1.9% of all MSVI worldwide, increasing from 2.1% and 1.3%, respectively, in 1990.', 'CONCLUSIONS: The number of persons with visual impairment due to DR worldwide is rising and represents an increasing proportion of all blindness/MSVI causes.', 'Age-standardized prevalence of DR-related blindness/MSVI was higher in sub-Saharan Africa and South Asia.', 'One out of 39 blind people had blindness due to DR, and 1 out of 52 visually impaired people had visual impairment due to DR.'], ['Because adult CECs have no proliferative capacity, the loss of CECs during aging or under pathological conditions would lead to corneal edema, eventually leading to the blindness.'], ["The most common age-related conditions are neurodegenerative disorders such as Parkinson's disease and blindness.", 'Age-related macular degeneration (AMD) is the leading cause of blindness in the elderly.'], ['It is the leading cause of blindness in people over 65 years in industrialized countries.'], ['Age-related macular degeneration (AMD), affecting the retinal pigment epithelium (RPE), is the leading cause of blindness in middle-aged and older people in developed countries.'], ['CONCLUSIONS: Boston type I keratoprosthesis is an effective modality in corneal blindness in elderly patients.'], ['Cataract is the major cause of blindness worldwide.', 'The WHO has estimated around 20 million people have bilateral blindness from cataract, and that number is expected to reach 50 million in 2050.'], ['Age-related macular degeneration (AMD) is the leading cause of blindness in the elderly.'], ['Cataract is considered to be the primary reason for curable blindness that is caused by progressive loss of lens transparency and affects millions of people around the world.'], ['Optic neuropathies are an important cause of blindness worldwide.'], ['Despite a high level of awareness of eye disease such as cataract, only 2 in 10 people could accurately identify cataract as a major cause of poor vision or blindness.', 'Most of the people (52%) blamed bad vision or blindness on dust or other foreign objects getting into the eye, old age (31%), or poor hygiene (16%).'], ['Tracking the number and characteristics of individuals with VI and blindness is especially important given the negative effect of these conditions on physical and mental health.', 'OBJECTIVES: To determine the demographic and geographic variations in VI and blindness in adults in the US population in 2015 and to estimate the projected prevalence through 2050.', 'DESIGN, SETTING, AND PARTICIPANTS: In this population-based, cross-sectional study, data were pooled from adults 40 years and older from 6 major population-based studies on VI and blindness in the United States.', 'Prevalence of VI and blindness were reported by age, sex, race/ethnicity, and per capita prevalence by state using the US Census projections (January 1, 2015, through December 31, 2050).', 'MAIN OUTCOMES AND MEASURES: Prevalence of VI and blindness.', 'By 2050, the numbers of these conditions are projected to double to approximately 2.01 million people with blindness, 6.95 million people with VI, and 16.4 million with VI due to uncorrected refractive error.', 'From 2015 to 2050, the states projected to have the highest per capita prevalence of VI are Florida (2.56% in 2015 to 3.98% in 2050) and Hawaii (2.35% in 2015 and 3.93% in 2050), and the states projected to have the highest projected per capita prevalence of blindness are Mississippi (0.83% in 2015 to 1.25% in 2050) and Louisiana (0.79% in 2015 to 1.20% in 2050).'], ['GCA is the most common vasculitis in adults and affects medium and large arteries and can result in blindness if untreated.'], ['Neovascular eye diseases are a major cause of blindness including retinopathy of prematurity, diabetic retinopathy and age-related macular degeneration in which new vessel formation is driven by hypoxia or metabolic abnormalities affecting the fuel supply.'], ['Systemic glucose toxicity can have devastating effects leading to pancreatic beta cell failure, blindness, nephropathy, and neuropathy, progressing to limb ulceration or even amputation.'], ['Age-related macular degeneration (AMD) is a leading cause of blindness among the aging population.'], ['Corneal endothelial disorders collectively represent a significant healthcare burden in most developed nations, and corneal transplantation is currently the only treatment available for patients with poor visual acuity and corneal blindness secondary to endothelial failure.'], ['Diabetes is the eighth cause of death, the sixth cause of blindness, and the leading cause of end-stage kidney disease and nontraumatic lower limb amputation.'], ['It is also the most common cause of blindness in working-age adults in industrialised nations.'], ['BACKGROUND: Age related macular degeneration (AMD) is the leading cause of irreversible blindness in the elderly population.'], ['Particularly important is the essential role of activated Rac1 in CEC transmigration of the RPE monolayer, an important step in blindness associated with neovascular AMD.'], ['BACKGROUND: Cataract is one of the main causes of blindness in the world.'], ["Age-related macular degeneration (AMD) represents a leading cause of blindness in the elderly, and Stargardt's macular dystrophy (SMD) is the most common form of juvenile-onset macular degeneration."], ['Subretinally-deposited amyloid-beta (Abeta) is an important factor in age-related macular degradation (AMD) often leading to irreversible blindness in the elderly population.'], ['Neovascular age-related macular degeneration (AMD) and polypoidal choroidal vasculopathy (PCV) are leading causes of blindness in aging populations.'], ['BACKGROUND: Central vision loss caused by age-related macular degeneration (AMD) is the leading cause of blindness among the elderly in developed countries.'], ['Age-related macular degeneration (AMD) is a major cause of blindness among the elderly in the developed world.'], ['Method: Visual impairment was measured in 2 ways: self-reporting fair vision or worse (moderate) and self-reporting poor vision or blindness (severe).'], ['Age-related eye diseases, the leading cause of blindness globally and visual impairment in developed countries, are also on the rise due to aging of the population.'], ['Polypoidal choroidal vasculopathy (PCV) is an exudative maculopathy, with clinical features distinct from neovascular age-related macular degeneration (nAMD) which is the leading cause of irreversible blindness in the elderly.'], ['In 206 participants without history of stroke/transient ischemic attack, 27.7% reported stroke symptoms, with sudden loss of comprehension most frequently reported (11.7%).'], ['Age-related cataract formation is the primary cause of blindness worldwide and although treatable by surgical removal of the lens the majority of sufferers have neither the finances nor access to the medical facilities required.'], ['Age-related macular degeneration (AMD) is a disease that causes varying degrees of blindness, which afflicts millions of adults in their later years.'], ['AIM: To determine the perception and attitudes of a rural community regarding the etiology, prevention, and treatment of blindness in adults.', 'Consumption of certain types of food was an important cause of blindness as perceived by 57.9% of the respondents, followed by supernatural forces (41.7%) and aging (19%).', 'Sixty percent of respondents thought blindness could be prevented.', 'Age (P = 0.04) and level of education (P =0.003) significantly affected the beliefs on the prevention of blindness.', 'Over half (56.6%) believed that spectacles could cure all causes of blindness.', 'However, the overall knowledge, attitude, and perceptions of this community need to be redirected to favor the eradication of avoidable blindness.'], ['Advanced age-related macular degeneration (AMD) is the leading cause of blindness in the elderly, with limited therapeutic options.'], ['Cataract is extremely common in people of all skin colours and is a frequent cause of blindness, particularly in the elderly.'], ['Injection in this area is not without risk, including potential blindness.'], ['VI (including blindness) was defined as presenting VA of worse than 20/60 in either eye.'], ['Worldwide, the prevalence of moderate to severe visual impairment and blindness is 285 millions, with 65% of visually impaired and 82% of all blind people being 50 years and older.', 'Cataract accounts for more than half of all blindness globally and gender inequity in access to cataract surgery is the major cause of the higher prevalence of blindness in women.'], ['Glaucoma is a common ocular condition in humans and dogs leading to optic nerve degeneration and irreversible blindness.'], ['In addition, two legal abortions and one second trimester miscarriage occurred.'], ['INTRODUCTION: To put a blindness prevention program into practice in remote districts of Eastern Taiwan, a Mobile Vision Van Unit (MVVU) was established to work as a community eyecare station.', 'The ages of those screened ranged from preschool children to the elderly, and 2073 patients were referred to secondary or tertiary centres in the middle-aged and elderly blindness prevention program.', 'CONCLUSIONS: An MVVU model for blindness prevention is highly feasible in its efficiency and cost-effectiveness in communities with deficient medical resources.'], ['Age-related macular degeneration (AMD) is the leading cause of blindness in the aged people.'], ['Age-related macular degeneration (AMD) is the leading cause of acquired and irreversible blindness among elderly Americans.'], ["ND included: Parkinson's disease, dementia, stroke, hear loss, tinnitus, blindness, vertigo, neurosyphilis, systemic sclerosis, and epilepsy."], ['PURPOSE: To determine whether blindness in older people is associated with increased health service use and mortality.'], ['Cataract is the leading cause of blindness worldwide and accounts for approximately half of all forms of vision loss.'], ['BACKGROUND: Age-related macular degeneration (AMD) is the most common cause of blindness in the elderly, with no therapy available for 90% of patients.'], ['Age-related macular degeneration (AMD) is the leading cause of irreversible blindness in the elderly.'], ['Knowledge of cataract symptoms, how to evaluate them, and a basic understanding of the surgery to correct cataracts make primary care physicians an integral part of treating this leading cause of preventable blindness.'], ['Although rare, more serious complications include infection, foreign body granuloma, intravascular necrosis, and blindness due to embolization into the ophthalmic artery.'], ['PURPOSE: To evaluate frequency, conversion rate, and risk factors for blindness in glaucoma patients treated in European Universities.', 'RESULTS: Unilateral and bilateral blindness were respectively 11.0% and 1.6% at the beginning, and 15.5% and 3.6% at the end of the observation period (7.5+-5.5 years, range:1-25 years); conversion to blindness (at least unilateral) was 1.1%/year.', '134 eyes (97 patients) developed blindness by POAG during the study.', 'CONCLUSIONS: In this series of patients, blindness occurred in about 20%.'], ['CONCLUSIONS: Based on our data comparing human IL-18 to current anti-VEGF-based therapy, clinical deployment of IL-18 for neovascular AMD has the potential to lead to a new adjuvant immunotherapy-based treatment for this severe form of central blindness.'], ['Though pulmonary manifestations are predominant, ocular sarcoidosis (OS) affects 25-50% of patients with sarcoidosis and can lead to blindness.'], ['In the eye, choroidal neovascularization (CNV) causes blindness in patients with age-related macular degeneration (AMD).'], ['Since HIV has become a chronic disease, its long-term effects with respect to visual function loss become more important, as is recently emphasized by a longitudinal study, reporting that AIDS patients with HIV-NRD have higher risks of developing bilateral visual impairment and even blindness than patients without HIV-NRD.'], ['If untreated, ischaemic complications can be catastrophic for the patient, including blindness.'], ['Age-related macular degeneration (AMD) is a degenerative retinal disease that causes blindness in people 60-65 years and older, with the highest prevalence appearing in people 90 years-old or more.'], ['Primary angle-closure glaucoma is potentially a devastating disease, responsible for half of glaucoma-related blindness worldwide.'], ['Age-related macular degeneration (AMD) is the leading cause of blindness among the elderly in developed countries.'], ['Glaucomatous optic neuropathy, an important neurodegenerative condition and the commonest optic neuropathy in humans, is the leading cause of irreversible blindness worldwide.'], ['The Tanjong Pagar Eye Study reported the prevalence and risk factors of glaucoma in a Singapore Chinese population in 1997, which established the higher rates of blindness in this population.', 'Prevalence (95% CI) of blindness caused by secondary glaucoma was 14.3% (5.7%-31.5%), followed by 10.2% (4.4%-21.8%) for PACG and 8.8% (3.8%-18.9%) for POAG.'], ['This phenomenon is called change blindness.', 'Previous research has shown that change blindness increases with age.'], ['Dysfunction of the human trabecular meshwork (HTM) plays a central role in the age-associated disease glaucoma, a leading cause of irreversible blindness.'], ['BACKGROUND: Anterior ischemic optic neuropathy (AION) is characterized by infarction of the optic nerve head due to hypoperfusion of the posterior ciliary arteries and causes sudden blindness in adults on chronic dialysis, but has rarely been described in children.', 'RESULTS: Our 7 patients suffered from acute onset bilateral blindness.', 'CONCLUSIONS: Hypotensive children treated with CCPD are at increased risk of developing AION, which often results in irreversible blindness.'], ['PURPOSE: Cataract is the world-leading cause of blindness.'], ['Second, recent research shows that almost all the TGA patients displayed modifications of their emotional state during the episode, possibly linked to sudden memory loss.'], ['It is a major cause of blindness in the aging population.'], ['BACKGROUND: Age-related Macular Degeneration (AMD) is the leading cause of irreversible and predictable blindness among older adults with serious physical and mental health consequences.'], ['BACKGROUND: Trachoma, caused by Chlamydia trachomatis (Ct), is the leading infectious cause of blindness worldwide.'], ['Age-related macular degeneration is the leading cause of blindness in people over 65 years in industrialized countries.'], ['Visual impairment was identified using Read Code ever recorded for blindness and/or low vision (within electronic medical records).'], ['Age-related macular degeneration (AMD) is a major cause of blindness in older people and is caused by loss of the central region of the retinal pigment epithelium (RPE).'], ['Blindness is a common cause of major sensory loss, with an estimated 39 million people worldwide suffering from total blindness in 2010.', 'In this review, we detail these and other challenges facing developers of cortical visual prostheses in addition to briefly outlining the epidemiology of blindness, and the history of cortical electrical stimulation in the context of visual prosthetics.'], ['Oxidative stress-mediated injury to the retinal pigment epithelium (RPE) is a major factor involved in the pathogenesis of age-related macular degeneration (AMD), the leading cause of blindness in the elderly.'], ['OBJECTIVE: The present population-based study was undertaken to estimate the prevalence, determinants and causes of corneal morbidity and blindness in a rural North Indian population.', 'Prevalence of corneal disease was 3.7% (95% CI 3.4% to 4.1%) and that of corneal blindness was 0.12% (95% CI 0.05% to 0.17%).', 'Corneal diseases contributing to blindness were post-surgical bullous keratopathy (46.2%) and corneal degenerations (23.1%).', 'CONCLUSIONS: The study findings demonstrate that currently ocular trauma, infectious keratitis, post-surgical bullous keratopathy, and corneal degenerations are responsible for the major burden of corneal blindness and morbidity in the Indian population.'], ["Zinc has been very successfully used as a therapeutic modality for the management of acute diarrhea in children, Wilson's disease, the common cold and for the prevention of blindness in patients with age-related dry type of macular degeneration."], ['Decreased incidences of blindness in patients with AMD and increased atheroprotective effect have been observed in the zinc supplemented elderly.'], ['In the developed world, age-related macular degeneration (AMD) is the leading cause of blindness in the elderly, with more than 7.2 million people afflicted in the U.S. alone.'], ['Cellular events responsible for the initiation of major neurodegenerative disorders of the eye leading to blindness, including age-related macular degeneration, Stargardt and Best diseases, are poorly understood.', 'Findings suggest that accumulation of vitamin A dimers such as A2E in the human eye might be responsible for the formation of ubiquitous RPE debris, an early indication of retinal degeneration, and that preventing or reducing the accumulation of vitamin A dimers is a prudent strategy to prevent blindness.'], ['METHODS: Utility assessments using the visual analog scale (VAS), time trade-off (TTO), and standard gamble (SG) were used to obtain utilities scores for arm deformity, monocular blindness, and binocular blindness from a sample of the general population and medical students.', 'RESULTS: All the measures for arm deformity of the 107 volunteers (VAS, 0.80 +- 0.14; TTO, 0.91 +- 0.12; SG, 0.94 +- 0.10) were significantly different (P < 0.001) from the corresponding measures for monocular blindness and binocular blindness.'], ['Public subsidisation and the development of antidotes (such as vitamin K for warfarin) for the new oral anticoagulants may have a positive effect on the under-treatment of AF.'], ['Previous research has shown that aging increases susceptibility to inattentional blindness (Graham and Burke, Psychol Aging 26:162, 2011) as well as individual differences in cognitive ability related to working memory and executive functions in separate studies.', 'Using the inattentional blindness paradigm developed by Most et al.', "(Psychol Rev 112:217, 2005), we investigated whether rates of inattentional blindness could be predicted by participant's performance on the Raven's Advanced Progressive Matrices and a choice-reaction time task."], ['Corneal endothelial transplantation or endothelial keratoplasty has become the preferred choice of transplantation for patients with corneal blindness due to endothelial dysfunction.'], ['Age-related macular degeneration (AMD) is one of the leading causes of blindness worldwide in the elderly population.'], ['Pathologies affecting the posterior segment of the eye are one of the major causes of blindness in developed countries and are becoming more prevalent due to the increase in society longevity.'], ['Retinal ganglion cells (RGC) neuropathy is a progressive optic nerve neuropathy with RGC death and axonal degeneration, and it leads to blindness in the elderly population worldwide.'], ['Age-related macular degeneration (AMD) is a common yet complex retinal degeneration that causes irreversible central blindness in the elderly.'], ['RESULTS: Clinical, biochemical, and molecular data from anterior and posterior eye segment diseases point to OS as the common pathogenic mechanism in the majority of these ocular disorders, many of which are pathologies causing visual impairment, blindness, and subsequent loss of life quality.'], ['Age-related macular degeneration (AMD) is the leading cause of blindness among the elderly.'], ['METHODS: Based on a systematic review of medical literature, prevalence of moderate and severe vision impairment (MSVI; presenting visual acuity <6/18 but >=3/60 in the better eye) and blindness (presenting visual acuity <3/60) was estimated for 1990 and 2010.', 'RESULTS: Age-standardised prevalence of blindness and MSVI decreased from 0.2% to 0.1% (3.314 million to 2.736 million people) and from 1.6% to 1.0% (25.362 million to 22.176 million), respectively.', 'Cataract was the most frequent cause of blindness in all subregions in 1990, but macular degeneration and uncorrected refractive error became the most frequent causes of blindness in 2010 in all high-income countries, except for Eastern/Central Europe, where cataract remained the leading cause.', 'Glaucoma and diabetic retinopathy were fourth and fifth most common causes for blindness for all regions at both times.', 'CONCLUSIONS: In highly developed countries, prevalence of blindness and MSVI has been reduced by 50% and 38%, respectively, and the number of blind people and people with MSVI decreased by 17.4% and 12.6%, respectively, even with the increasing number of older people in the population.', 'In high-income countries, macular degeneration has become the most important cause of blindness, but uncorrected refractive errors continue to be the leading cause of MSVI.'], ['Early blindness results in both structural and functional changes of the brain.'], ['OBJECTIVE: To present regional estimates of the magnitude and temporal trends in the prevalence and causes of blindness and moderate/severe visual impairment (MSVI) in Latin America and the Caribbean (LAC).', 'RESULTS: In the LAC combined region, estimated all-age both-gender age-standardised prevalence of blindness halved from 0.8% (0.6 to 1.1) in 1990 to 0.4% (0.4 to 0.6) in 2010 and MSVI decreased from 4.3% (3.1 to 5.3) to 2.7% (2.2 to 3.4).', 'In the Caribbean, estimated all-age both-gender age-standardised prevalence of blindness decreased from 0.6% (0.4 to 0.8) in 1990 to 0.5% (0.4 to 0.6) in 2010 and MSVI decreased from 3.3% (1.3 to 4.1) in 1990 to 2.9% (1.8 to 3.8).', 'In 2010, cataract continues to contribute the largest proportion of blindness, except in Southern Latin America where macular degeneration is most common.'], ['It primarily affects medium and large arteries of the head and neck and can cause stroke and blindness.'], ['The aim of this study was to assess the health literacy of common ocular diseases, namely cataract, glaucoma, night blindness, trachoma and diabetic retinopathy in Nepal.', 'Participants responded to trained enumerators using verbally administered, semi structured questionnaires on their awareness and knowledge of cataract, glaucoma, diabetic retinopathy, night blindness, and trachoma.', 'RESULTS: The awareness of cataract across the entire sample was 49.6%, night blindness was 48.3%, diabetic retinopathy was 29%, glaucoma was 21.3% and trachoma was 6.1%.', 'Patients presenting to rural outreach clinics had poorer awareness of cataract, glaucoma, diabetic retinopathy, night blindness and trachoma compared to those from a semi-urban community and an urban eye hospital (p<0.05), Old age was directly associated with poorer awareness of cataract, glaucoma, night blindness, trachoma and diabetic retinopathy (p<0.05).', 'Similarly, awareness of cataract, glaucoma, trachoma and night blindness was associated with female gender (p<0.05) whereas awareness of cataract, night blindness, trachoma and diabetic retinopathy was associated with age (p<0.05) but the awareness glaucoma and diabetic retinopathy was associated with camps.'], ['Age-related macular degeneration (AMD) is the most common cause of irreversible visual impairment among people over 50 years of age, accounting for up to 50% of all cases of legal blindness in Western countries.'], ['Progressive inherited retinal degenerative disorders (PIRDDs) are the leading cause of blindness in developed countries, with AMD and RP constituting the majority of PIRDDs.'], ['UNLABELLED: Age related macular degeneration (AMD) is the most frequent cause of blindness in the elderly.'], ['A modest reduction would have significant impact as the numbers of persons affected with these two leading causes of blindness are projected to double in the next decade.'], ["Another major age-related eye disease of the cornea that leads to vision impairment and potentially blindness if left untreated is Fuchs' endothelial corneal dystrophy."], ['Legally, numerous changes in human rights, equality, consent, capacity, and end-of-life laws and professional guidance have consistently re-emphasised the need for greater communication between doctors, patients, their relatives and carers.'], ['Age-related macular degeneration (AMD) is the leading cause of irreversible blindness in the elderly population in the Western world.'], ['In multivariable analysis, after adjusting for age, gender, diabetes, hypertension, body mass index, smoking and education status the mortality HR was 1.9 (95% CI: 1.5-2.5) for blindness; 1.4 (95% CI: 1.2-1.7) for VI; 1.8 (95% CI: 1.4-2.3) for pure nuclear cataract, 1.5 (95% CI: 1.1-2.1) for pure cortical cataract; 1.96 (95% CI: 1.6-2.4) for mixed cataract, 2.0 (95% CI: 1.4-2.9) for history of cataract surgery, and 1.58 (95% CI: 1.3-1.9) for any cataract.', 'When all these factors were included in the model, the HRs were attenuated, being 1.5 (95% CI: 1.1-2.0) for blindness and 1.2 (95% CI: 0.9-1.5) for VI.'], ['Lipofuscin accumulation in retinal pigment epithelial (RPE) cells of the eye implicates the etiologies of Stargardt disease and age-related macular degeneration, a leading cause of blindness in the elderly.'], ['AMD (age-related macular degeneration) is a neurodegenerative disease causing irreversible central blindness in the elderly.'], ['The purpose of this study was to determine the prevalence of VI and blindness and to explore the association between severity of VI and vision-specific QoL among older people living in nursing homes of Kathmandu, Nepal.', 'The prevalence of VI and blindness was 45.57% and its leading cause was cataract, which was followed by age-related macular degeneration, corneal opacity, glaucoma and macular scar.', 'CONCLUSION: VI and blindness are highly prevalent among older people living in nursing homes.'], ['Age-related macular degeneration (AMD) is the most common cause of blindness among the elderly.'], ['Age-related macular degeneration (AMD) is the most common cause of blindness in the elderly population.'], ['Age-related macular degeneration (AMD) is the leading cause of blindness in the elderly population.'], ['AIMS: Age-related macular degeneration (AMD), a major cause of legal blindness in the elderly, is associated with genetic and environmental risk factors, such as cigarette smoking.'], ['Of these, 72.5% knew corneal trauma might cause corneal ulceration, 37.6% knew corneal ulceration might cause blindness and 52.2% had received health education on corneal ulceration.'], ['A reason of this theory depends on the fact that certain disorders of the color eyesight, which include blindness to certain colors, cause blindness to pairs of opponent colors.'], ['Lens cataract is the leading cause of blindness in developing countries.', 'While cataract is primarily a disease of old age and is relatively rare in children, accounting for only four per cent of global blindness, childhood cataract is responsible for a third of the economic cost of blindness.'], ['Screening for open-angle glaucoma in patients with diabetic retinopathy is of utmost importance in the aging Puerto Rico population to prevent blindness.'], ['UNLABELLED: Age related macular degeneration (AMD) is the most frequent cause of irreversible blindness in the elderly population, affecting approximately 30-50 million people around the world.'], ['Age related macular degeneration (AMD) is one of the leading causes of blindness in Western society.'], ['PURPOSE: Cataract is the leading cause of reversible blindness worldwide, and the incidence of cataract surgery is projected to increase as the population ages.'], ['Age-related macular degeneration (AMD), the leading cause of irreversible vision loss and blindness among the elderly in industrialized countries, is associated with the dysfunction and death of the retinal pigment epithelial (RPE) cells.'], ["Zinc has been very successfully used as a therapeutic modality for the management of acute diarrhea in children, Wilson's disease, the common cold and for the prevention of blindness in patients with age-related dry type of macular degeneration and is very effective in decreasing the incidence of infection in the elderly."], ['BACKGROUND: Age-related macular degeneration (AMD) is one of the leading causes of blindness in the elderly worldwide.'], ['Age-related macular degeneration (AMD) is the leading cause of registered blindness among the elderly and affects over 30 million people worldwide.'], ['PURPOSE: Cataract is the leading cause of blindness worldwide, and is particularly common in low- and middle-income countries.', 'IMPLICATIONS FOR REHABILITATION: Cataract is the leading cause of blindness worldwide, and is particularly common in low- and middle-income countries.'], ['RESULTS: Low self-rated care satisfaction was associated with dependency in Instrumental Activities of Daily Living, blindness, faeces incontinence and anxiety, while high self-rated care satisfaction was associated with dependency in Personal Activities of Daily Living.'], ['Thus cell loss due to aging or corneal endothelial disorders leads to corneal edema and blindness-the leading indication for corneal transplantation.'], ['Age-related macular degeneration (AMD) is the leading cause of blindness in the elderly in the developed world.'], ['Age-related macular degeneration (AMD) is a multifactorial disease that represents the most common cause of irreversible visual impairment among people over the age of 50 in Europe, the United States, and Australia, accounting for up to 50% of all cases of central blindness.'], ['BACKGROUND: Age-related macular degeneration (AMD) is the leading cause of blindness in the elderly population.'], ['Age-related macular degeneration (AMD) is the leading cause of irreversible blindness in the elderly population worldwide.'], ['Complement factor H (CFH) is a central regulator of the complement system and has been implicated in the etiology of age-related macular degeneration (AMD), a leading cause of blindness in the elderly.'], ['The prevalence of low vision was 4.06 % (95 % confidence interval, 3.26, 4.56 %); that of blindness was 0.82 % (95 % confidence interval, 0.45, 1.19 %).', 'They would, therefore, benefit from a more aggressive and in-depth eye-care program as a blindness-prevention strategy.'], ['CONCLUSIONS: In contrast to the sudden loss of clinical efficacy of DBS caused by an open circuit, short circuits may arise due to a gradual decrease in impedance, causing the insidious development of neurological symptoms via limited or extended potential fields as well as shortened battery longevity.'], ['BACKGROUND: Some 70% of all cases of blindness in Germany are due to diseases of old age.', 'METHODS: We calculated the age- and sex-standardized prevalence of blindness in Germany using data from the archive of the blind registry of the Rhineland Regional Council (Landschaftsverband Rheinland, LVR) for the years 1978 to 2006.', 'We then validated the findings with the aid of data on blindness and visual impairment from the Statistics on Severe Disability (Schwerbehindertenstatistik, SBS) that are published periodically by the German Federal Statistical Office.', 'There was a corresponding trend in the prevalence of blindness in the Rhineland, which rose from 116.8 to 165.6 per 100,000 persons from 1978 to 1997 but was roughly the same, at 163.1 per 100,000 persons, in 2006.', 'The SBS data on blindness and visual impairment reveal a decline in prevalence from 392 to 372 per 100,000 persons between 1987 and 2005.', 'DISCUSSION: Blindness and visual impairment have become slightly less common in Germany, even though the population is aging.'], ['Age-related macular degeneration (AMD), a progressive condition that is untreatable in up to 90% of patients, is a leading cause of blindness in the elderly worldwide.'], ['RESULTS: The presence rates were 8.5% for blindness, 20.5% for visual impairment and 29% for visual disability including blindness and visual impairment.'], ['With the PVA, the prevalence of blindness and low vision was 3.59% and 15.22%, respectively.', 'Based on the BCVA, the predominant causes of blindness were cataract (70.5%), corneal opacity (8.2%), and glaucoma (6.6%).'], ['Visual acuity worse than 0.5 LogMAR (20/60) and 1.3 LogMAR (20/400) in the better eye was regarded as low vision and blindness, respectively.', 'The cause of blindness was determined by an ophthalmologist and in a person with more than one cause, the most correctable cause was regarded as the main cause.', 'On the basis of presenting visual acuity, the prevalence of low vision and blindness was found to be 1.8% (95% confidence interval (CI): 1.4-2.10) and 0.5% (95% CI: 0.3-0.7), respectively.'], ['Unilateral blindness was found in 80% of PACG, compared to only 36.3% of POAG cases.'], ['Age-related macular degeneration (AMD) is the leading cause of blindness in the elderly worldwide.'], ['Age-Related Macular Degeneration (AMD) is an eye disease that results in progressive and irreversible loss of central vision and is considered as the primary cause of visual impairment, including blindness, in the elderly in industrialized countries.'], ['Age-related macular degeneration (AMD) is the leading cause of irreversible blindness in industrial counties.'], ['Glaucoma, a group of intraocular pressure-related optic neuropathies, is characterized by the slow progressive neurodegeneration of retinal ganglion cells and their axons, resulting in irreversible visual sensitivity loss and blindness.'], ['PURPOSE: Age-related macular degeneration (AMD) is the leading cause of blindness in the elderly.'], ['All measures (VAS, TTO, SG); (0.89 +- 0.07, 0.94 +- 0.08, and 0.95 +- 0.10, respectively) varied (P < .0001) from the corresponding ones for monocular blindness (0.62 +- 0.18, 0.87 +- 0.15, and 0.85 +- 0.20, respectively) and binocular blindness (0.32 +- 0.18, 0.66 +- 0.25, and 0.64 +- 0.28, respectively).'], ['Age-related macular degeneration (AMD) is the leading cause of blindness among the elderly in developed countries.'], ['PURPOSE: To describe the development of the prevalence of blindness and low vision in the German population between 1993 and 2009 with respect to major demographic changes and to investigate how the prevalence of blindness would have developed without demographic aging.', 'RESULTS: The overall prevalence of blindness and low vision in Germany increased between 1993 and 2009 by 12.3% from 314,404 to 352,943 subjects.', 'At the same time, both age-specific prevalence rates as well as the prevalence that was based on a standardized population decreased, matching more than 30,000 fewer cases of blindness in 2009 as compared to 1993.', 'CONCLUSIONS: The increase in absolute prevalence numbers for blindness and low vision implies an increase in the ophthalmic workload.'], ['Treatment of circadian rhythm disorders, whether precipitated by intrinsic factors (e.g., sleep disorders, blindness, mental disorders, aging) or by extrinsic factors (e.g., shift work, jet-lag) has led to the development of a new type of agents called "chronobiotics".'], ['Assessment of binocular acuity revealed blindness in 109 (21.8%) and low-vision in 68 (13.6%).'], ['BACKGROUND: The overall prevalence of blindness from Onchoceriasis in Bushenyi is relatively low, most of which is to be found in the elderly.', 'The prevalence of blindness were 1.9% while 4.1% was visually impaired by acuity criteria alone.'], ['Because the lens becomes naturally more opaque over time, aging is the most important risk factor for developing cataract, which is a major cause of blindness in the world.'], ['The relationships between blindness or low vision and age, gender and education level were analysed.', 'MAIN OUTCOME MEASURES: The main outcome measure was prevalence rates of bilateral blindness and bilateral low vision.', 'The overall age-adjusted prevalence rates were 0.7% (95% confidence interval: 0.5-0.8%) for bilateral blindness and 1.7% (95% confidence interval: 1.4-1.9%) for bilateral low vision.', 'The prevalence rates of blindness and low vision were higher in the elderly and uneducated population (P < 0.05).', 'Eye care planning must focus on treating the avoidable and curable forms of blindness.'], ['Age-related macular degeneration (AMD) is the predominant cause of irreversible blindness in the elderly population.'], ['Age-related macular degeneration (AMD) is the leading cause of irreversible blindness in the elderly.'], ['Age-related macular degeneration (AMD) is the most common cause of blindness in older people in developed countries, and risk for this condition may be classified as genetic or environmental, with an interaction between such factors predisposing to this disease.'], ['UNLABELLED: Though research has examined race as an important factor in defining the scope of glaucoma in the United States, further exploration into other specific factors may help inform the design of preventive services to decrease rates of blindness due to glaucoma among minority groups.'], ['BACKGROUND: Age-related macular degeneration (AMD) is a primary cause of blindness among the elderly in developed countries.'], ["Because lens crystallin proteins do not turn over, the damage they accumulate can lead to cataracts, the world's leading cause of blindness."], ['UNLABELLED: The incidence of age-related macular degeneration (AMD), the main cause of blindness in older patients in the developed countries, is increasing with the ageing population.'], ['AIMS: To assess associations of visual function (VF) and quality of life (QOL) by visual acuity (VA), causes of blindness and types of cataract procedures in Nigeria.'], ['Forty-seven (26.9%) of the elderly had combined low vision associated with hearing impairment and 18 (10.2%) had combined blindness along with hearing impairment.'], ['INTRODUCTION: Diabetic retinopathy is the most common cause of blindness in the UK, with older people and those with worse diabetes control, hypertension, and hyperlipidaemia being most at risk.'], ['Age related macular degeneration (AMD) is the most common cause of blindness amongst the elderly.'], ['Age-related macular degeneration (AMD) is one of the major causes of blindness in aging population that progresses with death of retinal pigment epithelium (RPE) and photoreceptor degeneration inducing impairment of central vision.'], ['PARTICIPANTS: Nationally representative (U.S.) sample of older adults age 65 and older, categorized as having blindness (20/200 or worse), low vision (20/40 to 20/100) or normal vision (better than 20/40).'], ['Age-related macular degeneration (AMD) is the leading cause of blindness among the elderly in developed countries, and its pathogenesis is underlined by genetic and environmental factors.'], ['Age-related cataract is a cause of blindness on a global scale involving genetic and environmental influences.'], ['BACKGROUND: Age-related macular degeneration (AMD) is the leading cause of legal blindness in the elderly population.'], ['When engaged in an attention-demanding task, people are surprisingly vulnerable to inattentional blindness--the failure to notice an unexpected event.', 'Two theories of cognitive aging, attentional capacity models and inhibitory deficit models, make opposite predictions about age differences in susceptibility to inattentional blindness.', 'We tested these predictions using an inattentional blindness paradigm developed by Simons and Chabris (1999) and found that older adults were more likely to experience inattentional blindness than young adults.'], ['It is considered to be the major cause of irreversible blindness in the elderly population in the developed world.'], ['RECENT FINDINGS: Cataract is the leading cause of blindness, especially in developing countries.'], ['PURPOSE: The retinal pigment epithelium (RPE) is considered a primary site of pathology in age-related macular degeneration (AMD), which is the most prevalent form of irreversible blindness worldwide in the elderly population.'], ['It is a main theme of ophthalmologic research, because retinopathies are common causes of blindness in all age groups: age-related macular degeneration in the elderly, diabetic retinopathy in the middle aged, and retinopathy of prematurity and retinoblastoma in children.', 'In this review, we discuss the clinical manifestation, pathogenesis, and current treatment options for angiogenesis-related blindness.', 'In addition, because of the recent introduction of novel strategies, we describe pathogenesis-based treatment options to treat angiogenesis-related blindness.'], ['Cataract formation, the opacification of the eye lens, is one of the leading causes of human blindness worldwide, accounting for 47.8% of all causes of blindness.'], ['AMD, the leading cause of irreversible blindness among the elderly, involves many genetic and environmental risk factors, including oxidative stress and inflammation.'], ['Cataract and age-related macular degeneration (AMD) are two major causes of blindness, with cataract accounting for 48 per cent of world blindness and AMD accounting for 8.7 per cent.'], ['PURPOSE: Age-related macular degeneration is a leading cause of blindness in the elderly.'], ['World Health Organization recommended principal cause of blindness (Visual acuity [VA] < 3/60 in better eye), Severe visual impairment (SVI) (<6/60), low vision (VA < 6/18) and unilateral blindness (VA < 3/60) were designated.', 'The age sex adjusted prevalence of bilateral blindness was 1.28% [95% CI 1.22-1.35], SVI (1.67%), low vision (3.66%) and unilateral blindness (3.61%) in 50 years and older population.', 'CONCLUSIONS: To reduce avoidable blindness, un-operated cataract should be addressed.'], ['PURPOSE: Primary open angle glaucoma (POAG) is a leading cause of irreversible blindness in the elderly.'], ['Cataract will slowly diminish the vision leading to the blindness.'], ['We recently discovered that mRGCs resist neurodegeneration in two inherited mitochondrial disorders that cause blindness, i.e.'], ['The prevalence of presenting bilateral blindness (< 20/200) was 6.9% (95% CI: 5.7-8.1), and 3.1% (95% CI: 2.5-3.7) with best correction.', 'Presenting and best-corrected blindness were both associated with older age and illiteracy; gender and rural/urban residence were not significant.', 'Cataract in one or both eyes was the main cause of bilateral blindness (82.6%), followed by retinal disorders (8.9%).', 'Despite a reportedly high CSR, cataract remains the predominant cause of blindness.'], ['BACKGROUND: Age-related macular degeneration (AMD) is a leading cause of blindness in the elderly.'], ['Two members of the beta-crystallins, CRYBB1 and CRYBB2, have been identified in drusen preparations isolated from the retina of donor eyes of patients with age-related macular degeneration (AMD), the leading cause of blindness in the elderly population of developed countries.'], ['All patients had pathologically proven giant cell arteritis, and three of them progressed to blindness in the end.', 'Early recognition of TMVL is important to make early diagnosis of GCA to prevent blindness.', 'Spontaneous ear pain is extremely rare, and reports have documented delay in diagnosis of GCA resulting in irreversible blindness.'], ['A complex, multifactorial disease in which genetic and environmental factors interact, AMD is the leading cause of blindness in the elderly.'], ["With the world's aging population, it is expected that the number of people affected by glaucoma, the second most common cause of irreversible blindness, will increase considerably."], ['Reducing blindness from cataract requires solutions that can be applied outside operating theatres.'], ['Age-related macular degeneration (AMD) is the most prevalent form of irreversible blindness worldwide in the elderly population.'], ['Age-related macular degeneration (AMD) is a disease leading to severe visual loss and legal blindness in the elderly population.'], ['Zinc supplementation was effective in preventing blindness in 25% of the elderly with dry type of age related macular degeneration.'], ['PURPOSE: Age-related macular degeneration (AMD) is the most common cause of blindness in older people in developed countries, and risk factors for this condition may be classified as genetic and environmental.'], ['Total visual impairment was calculated as the sum of low vision and blindness.'], ['PURPOSE: Age-related macular degeneration (AMD) is the leading cause of blindness among older adults, in which oxidative damage may play a pivotal role.'], ['Lesions frequently result in scar formation that may cause blindness.'], ['METHODS: Recent population-based blindness surveys in established market economies were reviewed.', 'Vision screening and awareness campaigns focusing on the identified risk groups can reduce avoidable blindness considerably.'], ['PURPOSE: To examine the distribution and causes of corneal blindness in a rural Chinese population.', 'An eye was considered to have cornea blindness if the visual acuity was < 20/400 due to a corneal disease.', 'Corneal blindness in at least one eye was present in 48 participants, prevalence of 0.949% (95% CI: 0.682-1.216%) in at least one eye, which included 0.16% prevalence of corneal blindness in both eyes.', 'The most frequent causes of corneal blindness in at least one eye included keratitis during childhood (39.6%), keratitis during adulthood (27.1%), and trauma (20.8%).', 'We found that aging and male gender were associated with prevalence of corneal blindness.', 'Multivariate analysis shows a higher OR of corneal blindness in subjects age 70 and older (1.746) and male gender (1.177).', 'CONCLUSIONS: Corneal blindness is a public health problem in southern Harbin, the majority of which is either preventable or treatable.', 'Eye care planning must focus on corneal blindness as well as cataract.'], ['CONCLUSIONS: The goal of glaucoma treatment is to protect the patient from blindness and visual impairment while keeping the treatment-related decline in quality of life to a minimum.'], ['Although diabetes is clearly linked to macro- and microvasculopathy in multiple organs resulting in cardiovascular and cerebrovascular catastrophic diseases, blindness, and limb amputations, it is the relentless progression of diabetic nephropathy toward becoming the major cause of end-stage renal disease (ESRD) that now challenges budgets and treatment facilities providing hemodialysis, peritoneal dialysis, and kidney transplantation.'], ['Age-related macular degeneration (AMD) is the major reason of blindness of the elderly all over the world.'], ['CONCLUSION: Brazil has adopted legal hallmarks that substantially shifted public practices towards the elderly segment from a philanthropic status to a legitimate right for care and assistance.'], ['Cataract is still the dominant cause of blindness worldwide.'], ['Zinc supplementation has prevented blindness in 25% of the elderly individuals with dry type of AMD.'], ['INTRODUCTION: age-related macular degeneration (ARMD) is a leading cause of blindness in the elderly population.'], ['Recognizing an inherent genetic risk of AMD in these patients will improve their management and potentially help prevent blindness.'], ['In knock-out studies, disruption of CISD2 leads to accelerated aging, blindness and muscle atrophy.'], ['Age-related macular degeneration (AMD) is the leading cause of legal blindness among the elderly population in the industrialized world, affecting about 14 million people in the United States alone.'], ['Blindness incidence increased with advancing age, such as cataract and glaucoma, which are by far the commonest causes of blindness in our sample and in all age groups, glaucomatous neurodegeneration can be treated with developed NAC autoinduction prodrug eye drops equipped with corneal absorption promoters.'], ['The most common diseased state of the RPE becomes manifest in age-related macular degeneration, an increasing cause of blindness in the elderly.'], ['Some of this pathology serves as a sinister preamble to serious conditions such as age-related macular degeneration (AMD) which remains the leading cause of irreversible blindness in the Western world.'], ['This study was carried out to determine the level of correct knowledge about glaucoma and attitudes towards blindness prevention and treatment, and how these factors influence self care practices among teaching hospital workers.', 'Younger people believed blindness prevention and treatment were the highest priorities compared with other diseases.', 'Those who work in the ophthalmic unit and those who had relatives who had been blind from glaucoma also considered blindness treatment to be the highest priority compared with other diseases.'], ['Age-related macular degeneration (AMD) is the leading cause of blindness among older people, and diet has been postulated to alter risk of AMD.'], ['Known as shingles, this disorder can be excruciatingly painful with the potential to cause blindness if the optic nerve becomes involved.'], ['RESULTS: A total of 118 patients underwent CEA for non-disabling stroke, TIA and amaurosis fugax.'], ['Mutations and aging of crystallins cause cataracts, the predominant cause of blindness in the world.'], ['OBJECTIVE: To estimate the prevalence of blindness in the elderly population of Campinas, Brazil, and to describe the coverage and quality of cataract surgery services in the area.'], ['PURPOSE: Cataracts are a major cause of blindness worldwide.'], ['Retinal vein occlusion (RVO) is the second most common retinal vascular disease after diabetic retinopathy and is a common cause of visual morbidity and blindness in the elderly.'], ['METHODS: Focus groups and 1-on-1 interviews were conducted with legally blind U.S. English-speaking adults who served as informal caregivers of adults.'], ['The overall prevalence of bilateral blindness was 4.5% (confidence interval (CI) 95% 3.7%-5.3%).'], ["Change blindness (CB), the inability to detect changes in visual scenes, may increase with age and early Alzheimer's disease (AD)."], ['The gender and age profiles of people attending the clinics were not consistent with equitable blindness prevention.', 'Women and older people should be targeted by future programs to achieve equity of blindness prevention.'], ['Age-related macular degeneration (AMD) is a leading cause of irreversible blindness in the elderly.'], ['METHODS: Some 74 symptomatic (transient ischaemic attack (TIA) 17, amaurosis fugax 34, transient stroke 4, established stroke 10, progressive stroke 9) and 52 asymptomatic patients were studied with US and DSA.'], ['The definitions of blindness (VA < 20/400) and visual impairment (VA < 20/60 to > or = 20/400) were based on the presenting VA in the better eye.', 'The major causes of VI and blindness were identified.', 'The associations of bilateral VI and blindness by age, gender and education were calculated through multiple logistic regression.', 'The prevalence of bilateral blindness and VI was 1.9% (95% confidence interval (CI): 1.6 % to 2.3%) and 8.3%(95% CI: 7.5 % to 9.1%), respectively.', 'We found that age, female gender, and illiteracy were associated with bilateral blindness.', 'The leading cause of bilateral blindness was cataract (70.4%), followed by corneal opacity (8.2%) and glaucoma (5.1%).', 'CONCLUSIONS: Cataract is the dominant cause of bilateral blindness and VI in people over 50 years old in rural southern Harbin.'], ['Age-related macular degeneration (AMD) remains high incidence and accounts for a main cause of blindness in ageing people, but its mechanism is still poorly understood.'], ['Although epidemiological studies have reported the benefit of DHA in the prevention of age-related macular degeneration, the leading cause of blindness in Western countries, the relevance of supplementing patients with DHA is questioned.'], ['BACKGROUND: Rapid stepping reactions are a prevalent response to sudden loss of balance and play a crucial role in preventing falls.'], ['One patient had amaurosis fugax.'], ['A response of "poor" (referred to as poor vision) or "unable to see" (referred to as blindness) was considered visual impairment.', 'The overall prevalence was 6.2% for poor vision, 0.7% for blindness, and 6.8% for either.'], ['Cataracts, glaucoma, and age-related macular degeneration (AMD) are common causes of blindness in the elderly population of the United States.'], ['Dysregulation of the alternative pathway (AP) of complement cascade has been implicated in the pathogenesis of age-related macular degeneration (AMD), the leading cause of blindness in the elderly.'], ['The definitions of visual impairment were based on the pinhole visual acuity (low vision: visual acuity <6/18 to 3/60 in the better eye; blindness: visual acuity <3/60 in the better eye).', 'The prevalence of blindness and low vision based on the pinhole visual acuity was 1.35% (presenting, 1.32%) and 1.84% (presenting, 6.05%) respectively.', 'The prevalence of blindness and low vision grew up exponentially with age (R2=0.9993, F=1385.84, P=0.0007; R2=0.9949, F=195.65, P=0.0051) and down with increasing education level (score test for trend of odds: chi2=30.35, P=0.0000; chi2=22.31, P=0.0000), and was higher among women than men (LR chi2=9.62, P=0.0019; LR chi(2)=5.14, P=0.0234).', 'Therefore, our study highlights an urgent necessity for launching some programs for blindness and low vision prevention, especially on the early treatment of cataract.'], ['This condition remains the leading cause of irreversible blindness in industrialized countries, but its precise pathogenesis has yet to be completely elucidated.'], ['Age-related macular degeneration (AMD) is the leading cause of blindness among the ageing population.'], ['AMD causes irreversible blindness in the elderly.'], ['Although it remains unsubstantiated clinically, experimental results support that the accumulation of lipofuscin is related to an increased risk of choroidal neovascularization due to age-related macular degeneration, a leading cause of legal blindness.'], ['BACKGROUND: Age-related macular degeneration (AMD) is the major cause of blindness in the elderly.'], ['Cataract and lagophthalmos are the main causes of blindness.'], ['Prevalence of VI and blindness was defined according to the WHO criteria (0.5 log MAR <or= VA < 1.2 log MAR and VA >or= 1.2 log MAR) and the European criteria (0.3 log MAR <or= VA < 1 log MAR and VA >or= 1 log MAR) in the better eye.', 'The prevalence of VI and blindness according to the WHO criteria was 6.3 and 2%, respectively.', 'Using the European criteria, the prevalence of VI was 21.1 and 2.4% the prevalence of blindness.'], ['Dual sensory loss may present at any age as a result of genetic defect, accident, injury, disease, or environmental insult; however, most persons develop this condition as a result of age-related disease processes that rarely result in total deafness or blindness.'], ['Tobacco smoking and aging are among the few factors linked to age-related macular degeneration (AMD), a major cause of blindness in the elderly.'], ['Age-related macular degeneration is the leading cause of blindness in the elderly.'], ['Alstrom Syndrome is multisystemic, with cone-rod retinal dystrophy leading to juvenile blindness, sensorineural hearing loss, obesity, insulin resistance with hyperinsulinemia, and type 2 diabetes mellitus.'], ['Legal compulsion of treatment adds its own quota of contention which can be mitigated, but not entirely dispelled, by careful adherence to the law.'], ['OBJECTIVE: Age-related macular degeneration (AMD) is the leading cause of blindness and severe visual impairment among the elderly in the United States.'], ['An allotypic variant of FH, 402His, has been associated with age-related macular degeneration, the leading cause of blindness in the elderly.'], ['Age-related macular degeneration (AMD) is the commonest cause of blindness in the population over 60 years of age and accounts for over 50% of those registered blind in the UK.'], ['Complications such as heart disease, vascular disease, renal failure and blindness (Roberts, 2005) have all been reported.'], ['RESULTS: Cataract is the major cause of bilateral blindness (66.1%).', 'The adjusted prevalence of bilateral cataract blindness (best-corrected visual acuity [BCVA], <20/400) in people 50 years of age and older was 2.3% (95% confidence interval [CI], 1.8%-3.0%), or an estimated 3726 persons.'], ['PURPOSE: It has been suggested that early menopause increases the risk of aging-macula disorder (AMD), the major cause of incurable blindness with a dry and wet late subtype, and that exposure to endogenous or postmenopausal exogenous estrogens reduces this risk.'], ["Attitudinal barriers included: could manage daily work (71%), cataract not mature (68%), could see clearly with the other eye (64%), too busy (57%), female gender (37%), fear of surgery (34%), fear of surgery causing blindness (33%) or death (13%), old age (33%), it is God's will (29%) and worry about cost of surgery (27%)."], ["One of the hallmarks of age-related macular degeneration (AMD), the leading cause of blindness in the elderly in Western societies, is the accumulation of sub-retinal pigment epithelial deposits (sub-RPE deposits), including drusen and basal laminar deposits, in Bruch's membrane (BM)."], ['Cataract is a universal phenomenon in old age and the most common cause of blindness worldover.'], ['INTRODUCTION: Diabetic retinopathy is the most common cause of blindness in the UK, with older people and those with worse diabetic control, hypertension, and hyperlipidaemia being most at risk.'], ['PURPOSE: Choroidal neovascularization associated with age-related macular degeneration is the primary cause of blindness in the elderly in developed countries, due to a number of pathogenic effects, including angiogenesis, cell-mediated inflammation, leukocyte adhesion and extravasation, and matrix remodeling.'], ['Clusterin has been found to be a common protein identified in drusen preparations isolated from the retina of donor eyes of patients with age-related macular degeneration (AMD), the leading cause of blindness in the elderly population of developed countries.'], ['And yet, the quality of life during those additional years is often significantly diminished by the effects of age-related, degenerative diseases, including age-related macular degeneration (AMD), the leading cause of blindness in the elderly worldwide.'], ['PURPOSE: To determine the prevalence of blindness and visual impairment in adults aged 30 years and older in Pakistan and to assess socio-demographic risk factors.', 'The age- and gender-standardized prevalence of blindness was 2.7% (95% confidence interval [CI], 2.4%-2.9%).', 'Rural areas had a higher prevalence of blindness than did urban areas (3.8% vs. 2.5%, P < 0.001).', 'Regional variations in the prevalence of blindness were also identified.'], ['BACKGROUND: Cataract accounts for 50% of blindness globally and remains the leading cause of visual impairment in all regions of the world, despite improvements in surgical outcomes (WHO 2005).'], ['BACKGROUND: Angiogenesis is a key aspect of the wet form of age-related neovascular (AMD), the leading cause of blindness in the elderly population.'], ['In developed countries, age-related macular degeneration (ARMD) is a common cause of blindness in the elderly.'], ['The authors describe an elderly woman with recurrent, probably self-induced, ocular trauma leading to bilateral blindness.', 'The authors are unaware of any previously reported cases of Munchausen syndrome resulting in bilateral blindness and occurring in old age.'], ['OBJECTIVE: To describe the causes of low vision and blindness in a population-based sample of adult Latinos.', 'Consensus diagnosis of independent investigators reviewing all patient data was used to determine the major causes of low vision and blindness in adult Latinos.', 'MAIN OUTCOME MEASURES: Primary causes of vision loss in persons with low vision and blindness.', 'The primary causes of blindness were age-related macular degeneration, diabetic retinopathy, and myopic degeneration, accounting for 63% of the cases of blindness.', 'CONCLUSIONS: Many of the leading causes of low vision and blindness in adult Latinos are potentially preventable and treatable diseases.'], ['PURPOSE: Age-related macular degeneration (AMD), with its complex traits and multiple risk factors, is the leading cause of blindness in the elderly.'], ['AIMS: Prior to establishing a national prevention of blindness program a population based survey was conducted in Cape Verde Islands in1998.', 'The objectives of the survey were to estimate the overall and age-specific prevalence of blindness and low vision, to identify the main disorders causing blindness and low vision, and to estimate the population need for basic eye care services.', 'The prevalence of bilateral blindness (visual acuity in the better eye less than 3/60) was 0.8% (95% confidence interval [CI] 0.5-1.1), of bilateral low vision (6/18 to 3/60 in the better eye) 1.7% (95% CI: 1.3-2.2) and of monocular blindness 1.5% (95% CI: 1.2-2.0).', 'The major causes of blindness were age related cataract and glaucoma (57.7% and 15.4%, respectively, of blind people recruited).', 'Nontrachomatous corneal opacities accounted for 7.7% of bilateral and for 11.5% of monocular blindness.', 'Vascular retinopathy was responsible for 7.7% of bilateral and for 9.6% of monocular blindness.'], ['OBJECTIVES: We tested the hypothesis that modifiable lifestyle factors alter the genetic susceptibility associated with a common coding variant in the complement factor H (CFH) gene, Y402H, for the leading cause of blindness among the elderly, age-related macular degeneration (AMD).'], ['BACKGROUND: Public access defibrillation has been introduced to improve the outcome of patients experiencing out-of-hospital cardiac arrest (OHCA).'], ['A polymorphism in complement factor H has recently been associated with age-related macular degeneration (AMD), the leading cause of blindness in the elderly.'], ['That of functional blindness (presenting visual acuity less than 6/60 in the better eye) was 8.9% (95% CI: 8.4, 12.0, deff = 1.2), and of World Health Organization blindness (but presenting, rather than best corrected, visual acuity of less than 3/60 in the better eye) was 3.9% (95% CI: 3.4, 6.1, deff = 1.0).', 'Cataract was the most common (age-gender adjusted 6.4%, 95% CI: 5.1, 7.3, deff = 1.1) cause of functional blindness.', 'On bivariate analysis, increasing age (P < 0.001), illiteracy (P < 0.001) and unemployment (P < 0.001) were associated with functional blindness.'], ['Vascular complications are a leading cause of blindness, end-stage renal failure, a variety of neuropathies and accelerated atherosclerosis, which could account for disabilities and high mortality rates in patients with diabetes.'], ['Age-related macular degeneration (ARMD) is the leading cause of blindness in the elderly population not only Western but also Asian industrial countries.'], ['Patients with dementia, blindness, and immobility and those who were unable to give informed consent were excluded from this study.'], ["Treatment of circadian rhythm disorders, whether precipitated by intrinsic factors (e.g., sleep disorders, blindness, mental disorders, aging) or by extrinsic factors (e.g., shift work, jet-lag) has led to the development of a new type of agents called 'chronobiotics', among which melatonin is the prototype."], ['Age-related macular degeneration is the commonest cause of blindness in developed countries and the third most common worldwide.'], ['BACKGROUND: To provide information on the prevalence of visual impairment, blindness and the leading causes of visual changes among the elderly in Ife-Ijesha zone of Osun state in Nigeria.', 'They were all screened for various medical problems including eye ailments and blindness according to World Health Organisation (WHO) definition.', 'Cataract (42.3%), glaucoma (32.4%) and uncorrected aphakia (9.9%) were the leading causes of blindness in 69 eyes while 80% of visual impairment was due to cataract alone.', 'CONCLUSIONS: The prevalence of blindness and visual impairment in this study population is high.'], ['Age-related macular disease (AMD) is the leading cause of legal blindness among the elderly in Western nations.'], ['BACKGROUND: Age-related macular degeneration (AMD) affects approximately 10% of persons aged 65-74 years and 30% of those aged 75 and older and is the major cause of blindness in old age.'], ['Our objective was to investigate antioxidant paraoxonase 1 (PON1) activity together with malondialdehyde (MDA) levels to evaluate oxidative stress in patients with age-related macular degeneration (AMD), an important cause of blindness in the elderly population.'], ['CONCLUSION: Some misconceptions were identified, and the fear of blindness was the most mentioned reason for not seeking cataract surgery, which indicates the need for orientation.'], ['Age-related macular degeneration (ARMD) is the foremost cause of blindness among the elderly population in industrialised countries.'], ['Opacities (cataracts) in the lens of the eye are a leading cause of preventable blindness.'], ["SFD shares several pathological features commonly found in the 'wet' or exudative form of age-related macular degeneration (AMD), the most common cause of blindness in the elderly in developed countries."], ['Age-related macular degeneration (AMD) is the leading cause of blindness in developed countries.'], ['Onset of legal blindness resulted in a 78% increase in the likelihood of an IADL limitation (OR for no limitation: 0.22, P < .001).'], ['A cross-sectional study was conducted in the dry month of February 2000 in the Gurage Zone of Ethiopia (population over 1.5 million) to determine the magnitude of trachoma and blindness.'], ['The inclusion criteria were: ability to rise from a chair and walk 6m; no severe cognitive impairment or blindness; age 65 years or older.'], ['These compounds, which are members of the carotenoid family, are thought to prevent or delay the onset of age-related macular degeneration, the leading cause of irreversible blindness in the elderly.'], ['BACKGROUND: Age related macular degeneration (ARMD) is the most frequent cause of blindness among the elderly.'], ['Macular exudative manifestations secondary to choroidal neovascular lesions remain the leading cause of definitive visual impairment and legal blindness in the elderly.'], ['Pressure ulcers were more common among the elderly, men, African Americans, singles, subjects with education less than high school, unemployed, subjects with complete injury, and subjects with history of pressure ulcers, rehospitalization, nursing home stay, and other medical conditions.'], ['Age-related macular degeneration (AMD), for which inflammatory changes have been demonstrated, is the commonest cause of blindness in the elderly.'], ['Age-related macular degeneration (AMD) is the most frequent cause of irreversible blindness in the elderly in developed countries.'], ['Acute retinal vascular occlusive disorders collectively constitute one of the major causes of blindness or seriously impaired vision, and yet there is marked controversy on their pathogeneses, clinical features and particularly their management.', 'with aspirin and/or anti-coagulants; (xv) fibrinolytic agents can dissolve an organized thrombus in the CRV; (xvi) it is beneficial to lower blood pressure in patients with CRVO; (xvii) panretinal photocoagulation used in ischemic retinal venous occlusive disorders has no deleterious side-effects; (xviii) glaucoma or ocular hypertension can cause branch retinal vein occlusion; (xix) branch retinal vein occlusion can cause neovascular glaucoma; (xx) in eyes with CRAO, the artery is usually not completely occluded; (xxi) CRAO is always either embolic or thrombotic in origin; (xxii) amaurosis fugax is always due to retinal ischemia secondary to transient retinal arterial embolism; (xxiii) asymptomatic plaque(s) in retinal arteries do not require a detailed evaluation; (xxiv) retinal function can improve even when acute retinal ischemia due to CRAO has lasted for 20h or more; (xxv) CRAO, like ischemic CRVO, can result in development of ocular neovascularization; (xxvi) panretinal photocoagulation is needed for "disc neovascularization" in CRAO; (xxvii) fibrinolytic agents are the treatment of choice in CRAO; (xxviii) there is no chance of an eye with retinal arterial occlusion having spontaneous visual improvement; (xxix) absence of any abnormality on Doppler evaluation of the carotid artery or echography of the heart always rules out those sites as the source of embolism; and (xxx) absence of an embolus in the retinal artery means the occlusion was not caused by an embolus.'], ['The overall prevalence of visual disability (visual acuity of the better eye <0.5) was 17.7%, including 17.1% with visual impairment and 0.6% with blindness.', 'CONCLUSIONS: The geographic difference in the prevalence of vision-related eye disease, visual impairment, and blindness point to the importance of taking actions that suit local circumstances.', 'Our results also revealed that visual impairment and blindness are important visual health problems in the elderly Taiwanese population.'], ['An increased risk of AMD, which is the most commonly occurring cause of blindness in the United Kingdom, is yet another reason for people to stop smoking and governments to develop public health campaigns against this hazard.'], ['PXF was significantly associated with blindness (adjusted OR, 2.19; 95% CI: 1.16-4.13).', 'Unilateral blindness (41.2%; 95% CI: 29.81-52.39) and visual impairment (45.21%; 95% CI: 34.29-57.13) were also more common with PXF.', 'CONCLUSIONS: The association of PXF with blindness and aging has public health implications for India.'], ['Age-related macular degeneration (AMD) is a leading cause of blindness in the elderly.'], ['In people over 50, age-related macular degeneration (ARMD) has become the most common cause for severe visual loss and legal blindness in all industrialized nations.'], ['The proportion of enucleations and blindness decreased.', 'The progress in surgical techniques led to a significant reduction in the number of blind eyes after injury.', 'The proportion of enucleations and blindness decreased partly due to better surgical techniques, but mostly due to the decrease in injuries with usually poor outcome, such as gunshots, ruptures, and windscreen injuries.'], ['Nearly 36% of the participants selected blindness as the most feared disabling medical condition, which was substantially higher than conditions such as dementia, loss of limbs, deafness or aphasia.'], ['Cataract, a leading cause of blindness worldwide, is a multifactorial eye disease.'], ['Age-related macular degeneration (ARMD) is a major cause of severe vision loss and blindness among older people.'], ['Similarly, because informed consent documents are often written to prevent legal jeopardy, these technical documents, expressed in language sometimes difficult to understand, can prevent comprehension of basic issues, defeating the ethical purpose of human protection.'], ['Both SFD and ML have strong similarities to age-related macular degeneration (AMD), a major cause of blindness in the elderly population of the Western hemisphere.'], ['The problems contributing most to the population burden of disease as assessed by population attributable risk fractions were hemiparesis, arthritis, accidents (unintentional injuries), blindness and other eye diseases, kyphosis, weakness of limbs, deafness, and hypertension.'], ['OBJECTIVES: To estimate the cause-specific prevalence and distribution of blindness and low vision in the United States by age, race/ethnicity, and gender, and to estimate the change in these prevalence figures over the next 20 years.', 'METHODS: Summary prevalence estimates of blindness (both according to the US definition of < or =6/60 [< or =20/200] best-corrected visual acuity in the better-seeing eye and the World Health Organization standard of < 6/120 [< 20/400]) and low vision (< 6/12 [< 20/40] best-corrected vision in the better-seeing eye) were prepared separately for black, Hispanic, and white persons in 5-year age intervals starting at 40 years.', 'The leading cause of blindness among white persons was age-related macular degeneration (54.4% of the cases), while among black persons, cataract and glaucoma accounted for more than 60% of blindness.', 'CONCLUSIONS: Blindness or low vision affects approximately 1 in 28 Americans older than 40 years.', 'The specific causes of visual impairment, and especially blindness, vary greatly by race/ethnicity.'], ['Diabetes is a major cause of new-onset blindness, end-stage renal disease, and nontraumatic amputation in the United States.'], ['Age-related macular degeneration (AMD) is the leading cause of irreversible blindness in people over 60 years of age in the US and many other developed countries.'], ['Recurrent ocular inflammation, which occurs in approximately 50% of cases, is the major morbidity that may eventually lead to blindness.'], ["Cataracts are the leading cause of blindness worldwide, accounting for half of the world's 40 million blind."], ['Wet age-related macular degeneration (AMD) is the leading cause of blindness in the elderly population.'], ['We also show that the MP Raman spectroscopy technology has potential as a novel, highly specific method for rapid screening of carotenoid antioxidant levels in large populations at risk for vision loss from age-related macular degeneration, the leading cause of blindness of the elderly in the developed world.'], ['These pigments, consisting of lutein and zeaxanthin, are taken up from the diet and are thought to play an important role in the prevention of age-related macular degeneration, the leading cause of blindness in the elderly in the Western world.'], ['MAIN OUTCOME MEASURES: Low vision and blindness were defined as a best-corrected visual acuity in the eye with better vision worse than 20/60 to a lower limit of 20/400 and worse than 20/400, respectively, according to World Health Organization categories of visual impairment.', 'The rate of blindness and low vision was estimated to be 0.59% (95% confidence interval, 0.25%, 1.16%) and 2.94% (95% confidence interval, 2.11%, 3.99%), respectively.', 'CONCLUSIONS: The rate of blindness and low vision is close to that reported for other developed countries.'], ['BACKGROUND: Primary open-angle glaucoma (POAG) is a leading cause of blindness in aging adults.'], ['A clue that these new findings are of significance for the pathogenesis of neurodegenerative disease is provided by the observation that OPA-1, a dynamin-related GTPase regulating mitochondrial fusion, is mutated in humans with dominant optic atrophy, which is characterized by degeneration of retinal ganglion cells and childhood blindness.'], ['RESULTS: Cataract is the major cause of bilateral blindness (46.5%).', 'The age and sex adjusted prevalence of bilateral cataract blindness (VA < 3/60) in people of 50 years and older was 2.0% (95% CI: 1.2-3.2%), with a cataract surgical coverage of 92% for males and 73% for females, a significant difference.'], ['Many of them had not separated legally and were not receiving any maintenance from their husbands.'], ['Diabetes is the leading cause of kidney failure, blindness in adults, nervous system damage, and amputations.'], ['Giant cell arteritis as the underlying cause of blindness in the elderly is common in the West but is not seen except on rare occasions in South East Asia.'], ['UV light has often been investigated as a risk factor for the most common cause of blindness, human age-related cataract.'], ['PURPOSE: There is increasing evidence that the complement system may play a significant role in one of the leading diseases causing blindness in the elderly population, age-related macular degeneration.'], ['Lesions frequently result in scar formation, which may cause blindness.'], ['Elderly people often ignore the importance of seeking vision services and care to prevent blindness or visual impairment.'], ["The authors' current recommendation is that intravenous steroids should be given to patients with established visual loss or amaurosis fugax."], ['It has significant morbidity and causes severe visual impairment or blindness of the eye.'], ['Millions of people suffer from a wide variety of ocular diseases, many of which lead to irreversible blindness.', 'The leading causes of irreversible blindness in the elderly--age-related macular degeneration and glaucoma--will continue to effect more individuals as the worldwide population continues to age.'], ['The study enrolled 923 injured patients, of whom 421 were legally intoxicated (blood alcohol concentration [BAC] > or = 50 mg/dL) and 502 were not intoxicated (BAC < 50 mg/dL).'], ['AIMS: To predict the burden of blindness, partial sight, and visual impairment (binocular visual acuity 6/18 or less) due to late stage age related macular degeneration (AMD) in the ageing population of the United Kingdom.'], ['Preclinical safety testing may prevent ocular side effects that can range from mild, reversible blurred vision to permanent blindness.'], ['PURPOSE: To assess the prevalence of visual acuity impairment, blindness, and cataract surgery among older adults in rural southern India.', 'The prevalence of blindness, based on visual acuity worse than 6/60 in both eyes, was 6.0% (95% confidence interval [CI]: 5.1% to 6.9%) with presenting vision, and 2.5% (95% CI: 1.8% to 3.1%) with best correction.', 'Blindness with presenting visual acuity was associated with older age and illiteracy.', 'Cataract was the principal cause of blindness in one or both eyes in 69.4% of those presenting blind, and uncorrected aphakia and other refractive error affected 35.6% in at least one eye.', 'CONCLUSIONS: It appears that much has been done in the prevention of blindness in Sivaganga.', 'Nevertheless, blindness remains an important public health problem, mainly because of cataract and refractive error.', 'Prevention of blindness programs in the area should target these two causes, with special emphasis on the elderly and the illiterate.'], ['People with diabetes are 25 times more likely to develop blindness, 17 times more likely to develop kidney disease, 30-40 times more likely to undergo amputation, two to four times more likely to develop myocardial infarction and twice as likely to suffer a stroke than non-diabetics.'], ['RESULTS: Cataract is the major cause of bilateral blindness (54%), followed by glaucoma (25%).', 'The age and sex adjusted prevalence of bilateral cataract blindness (VA <3/60) in people of 50 years and older was 0.6% (95% CI: 0.4 to 0.9), with a cataract surgical coverage of 75% (people).'], ['AIMS: To estimate the magnitude and the causes of blindness through a community based nationwide survey in Oman.', 'The major causes of blindness were identified among those found blind.', 'RESULTS: A total of 11 417 people were examined (response rate 91.8%) The prevalence of blindness in the Omani population was estimated to be 1.1% (95% CI 0.9 to 1.3), blindness being defined according to the WHO Tenth Revision of the International Classification of Diseases.', 'Prevalence of blindness was clearly related to increasing age, with estimates of 0.08% for the 0-14 age group, 0.1% for the 15-39 age group, 2.3% for the 40-59 age group, and 16.8% for the group aged 60 +.', 'The northern and central regions had a higher prevalence of blindness (1.3% to 3%).', 'The major causes of blindness were unoperated cataract (30.5%), trachomatous corneal opacities (23.7%), and glaucoma (11.5%) CONCLUSIONS: Despite an active eye healthcare programme, blindness due to cataract and trachoma remains a public health problem of great concern in several regions of the sultanate.'], ['Age-related macular degeneration (AMD) is the leading cause of blindness in the elderly.'], ['Prevalence of visual impairment overall (binocular visual acuity <6/18) which was categorised separately into low vision (binocular visual acuity <6/18-3/60) or blindness (binocular visual acuity of <3/60).'], ['Overactive bladder (OAB) is a chronic, distressing condition characterised by symptoms of urgency (sudden overwhelming urge to urinate) and frequency (urinating more than eight times daily), with or without urge urinary incontinence (sudden involuntary loss of urine).'], ['Since it is the leading cause of blindness in the elderly in the developed world, there is a pressing need for better treatment.'], ['The Raman technique is objective and quantitative and may lead to a new method for rapid screening of carotenoid pigment levels in large populations at risk for vision loss from age-related macular degeneration, the leading cause of blindness in the elderly in the United States.'], ['In addition to the previously reported 1.84% prevalence of blindness (presenting distance visual acuity less than 6/60 or central visual field less than 20 degrees in the better eye) in this sample, 1237 people had moderate visual impairment, an adjusted prevalence of 8.09% (95% CI 6.89 to 9.30%).', 'CONCLUSIONS: These data suggest that there is a significant burden of moderate visual impairment in this population in addition to blindness.', 'This impending large burden of moderate visual impairment, the majority of which is due to the relatively easily treatable refractive error and cataract, would have to be taken into account while estimating the eye care needs in India, in addition to dealing with blindness.'], ['OBJECTIVES: To understand the reasons for poor cataract surgery uptake in people with blindness or severe visual impairment in rural South Africa.', 'RESULTS: Fear of surgery and a fatalistic attitude to the inevitability and irreversibility of blindness in old age were the main reasons for failure to attend for surgery.'], ['Drusen are abnormal extracellular matrix deposits characteristic of age-related macular degeneration (AMD), a leading cause of blindness in the aging human population.'], ['Often coexisting with PMR, temporal arteritis can lead to complications, including blindness, stroke, or cardiac sequelae.'], ['Unilateral blindness (acuity <6/60) was found in 7.9% of subjects and bilateral blindness in 1.8%.', 'Because of a rapidly ageing population, healthcare planners in Hong Kong must prepare for an increasing burden of visual disability and blindness.'], ['Variations in these internal and external phase relationships, such as those that occur in blindness, aging, morning and evening, and advanced and delayed sleep-phase syndrome, lead to sleep disruptions and complaints.'], ['Free Fe is cytotoxic, promotes oxidation/lipid peroxidation, has been implicated as a risk factor in cardiac disease, and is itself associated with age-related macular degeneration (ARMD), the leading cause of blindness in aging western societies.'], ['People with wet AMD have several limitations, including inability to read, inability to recognize faces or drive, and the disease often leads to blindness.'], ['Macular degeneration is a leading cause of blindness that affects the aged population.'], ['BACKGROUND: giant cell arteritis (GCA) is a systemic vasculitis that may affect the optic nerve and cause blindness (e.g.'], ['We are revising the rules to automatically adjust each year, based on any increases in the national average wage index, the average monthly earnings guideline we use to determine whether work done by persons with impairments other than blindness is substantial gainful activity; provide that we will ordinarily find that an employee whose average monthly earnings are not greater than the "primary substantial gainful activity amount," has not engaged in substantial gainful activity without considering other information beyond the employee\'s earnings; increase the minimum amount of monthly earnings and the minimum number of self-employed work hours in month that we consider shows that a person receiving title II Social Security benefits based on disability is performing or has performed "services" during a trial work period, and automatically adjust the earnings amount each year thereafter; increase the maximum monthly and yearly Student Earned Income Exclusion amounts we use in determining Supplemental Security Income (SSI) Program eligibility and payment amounts for student children, and automatically adjust the monthly and yearly exclusion amounts each year thereafter.'], ['Age-related macular degeneration (AMD) is the leading cause of legal blindness among the elderly.'], ['Age-related macular degeneration (AMD) is a leading cause of blindness in the elderly population.'], ['OBJECTIVE: To determine the cause of monocular and binocular blindness in a predominantly nonwhite urban community hospital setting.', 'Retinal disease was the leading cause of blindness (90 = 22.7%), with retinal vascular occlusions and retinal detachments accounting for more than half of retinal causes.', 'Trauma was the leading cause of blindness among subjects less than 40 years old and among blind new subjects.', 'The most common cause of blindness among the 40- to 59-year-old age group was diabetes, accounting for 26.1% of cases.', 'Age-related macular degeneration accounted for only 1.3% (n = 5) of blindness.', 'CONCLUSIONS: Retinal diseases, especially retinal vascular occlusions and retinal detachments, are leading causes of blindness in this predominantly nonwhite and uninsured subject population.', 'Diabetes was the leading cause of blindness among the 40- to 59-year-old population.', 'Age-related macular degeneration plays a relatively minor role in the cause of blindness in the study population.'], ['Presenting blindness was associated with increasing age, female gender, lack of schooling, and rural residence.', 'Cataract was the principal cause of blindness in one or both eyes in 67.5% of blind persons, with uncorrected aphakia and other refractive error affecting 18.4% in at least one eye.', 'CONCLUSIONS: Blindness, particularly blindness because of cataract, continues to be a significant problem among the elderly living in remote areas of rural northwest India.'], ['The majority of blind people live in developing countries, and generally, their blindness could have been avoided or cured.', 'Given the success of programmes in combating the most common causes of blindness (infectious diseases and malnutrition) which generally affect the young, and the projected demographic shift, age-related eye disease will become increasingly prevalent.', 'The definition of blindness needs to be rethought, to ensure that people with "economic" blindness are not forgotten.'], ['The macula of the human retina contains extraordinarily high concentrations of lutein and zeaxanthin, xanthophyll carotenoids that appear to play an important role in protecting against age-related macular degeneration, the leading cause of blindness among the elderly.'], ['Health professionals and aged-care workers should be alert to the possibility of this preventable cause of blindness and work collaboratively to ensure that patients receive timely and appropriate treatment.'], ['BACKGROUND: Many individual surveys of blindness have reported slightly higher rates of blindness for women.', 'In order to gain a continent-by-continent and global sense of the burden of blindness by sex we conducted a meta-analysis of published, population-based surveys of blindness.', 'Globally, women bear excess blindness compared to men.', 'The excess of blindness in women was marked among the elderly and not due only to differential life expectancy.', 'CONCLUSION: The excess burden of blindness among women is likely due to a number of factors, which are different in industrialised countries compared to developing countries.', 'Particular attention to gender differences in blindness is needed in the creation of targets for blindness reduction and in the development of interventions.'], ['A logistic regression model predicting depressive symptoms found that the duration of institutionalisation (odds ratio 0.75; 95% confidence interval 0.59-0.94), and functional ability (odds ratio 0.96; 95% confidence interval 0.92-0.99), were independently and inversely associated with depressive mood after controlling for age and duration of blindness.', 'The effects of blindness and living in a long-term care institution were identified.'], ['Seventy-one (22%) of 318 women had bilateral profound visual impairment (blindness), defined as best-corrected visual acuity <3/60 and/or visual field constriction <5 degrees compared with 10 (12%) of 85 men.', 'The age-adjusted rate of blindness or profound visual impairment in the VIP institutional cohort of 5.2% (95% confidence interval [CI], 1.8, 8.6) was significantly greater than in the VIP urban and rural cohorts of 0.13% (95% CI, 0, 0.25) and 0.29% (95% CI, 0, 0.57), respectively.'], ['In Western countries, age-related macular degeneration is the leading cause of legal blindness in the population over 60 years of age, and cataract is the leading cause of visual impairment worldwide.'], ['Visual ischemic complications were observed in 42 (26.1%), and irreversible blindness, mainly due to anterior ischemic optic neuropathy and frequently preceded by amaurosis fugax, was found in 24 (14.9%).', 'Patients with other ischemic complications developed irreversible blindness more frequently.', 'The best predictors of irreversible blindness (permanent visual loss) were amaurosis fugax (OR 12.63) and cerebrovascular accidents (OR 26.51).', 'The presence of other ischemic complications constitutes an alarm for the development of irreversible blindness.'], ['Legal cases were analyzed that involved violence resulting in staff injury, patient assaults on staff, accidents involving the elderly, and patient self harm or injury where there was also an alleged breech in the duty of care.'], ['Increased expression of TIMP-3 is also observed in other degenerative retinal diseases, including the more severe forms of age-related macular degeneration, the most common cause of blindness in the elderly in developed countries.'], ['Age-related macular degeneration (AMD) is a common cause of legal blindness in the developed countries in people older than 50 years of age.', 'AMD complicated by choroidal neovascular membranes (CNV) accounts for 12% of AMD, but for 88% of legal blindness cases.'], ['Orientation and mobility should be offered to any individual who is legally blind or has difficulty with safe travel.'], ['Eye diseases, including cataract and blindness, were also common.'], ['Some patients however, have aggressive neovascular disease resistant to laser treatment, or present at a late stage with advanced fibroproliferative disease, and may progress rapidly to blindness.'], ['Specifically, we are raising from $500 to $700 the average monthly earning guidelines used to determine whether work done by persons with impairments other than blindness is SGA.'], ['PURPOSE: To assess blindness prevalence and that caused specifically by cataract in rural southern China.', 'Differences in blindness prevalence associated with age, gender, and education were explored using logistic regression.', 'RESULTS: Bilateral blindness (presenting visual acuity < 0.10) was found in 4.37% (95% confidence interval, 3.67%-5.06%).', 'Cataract was the principal cause of blindness in at least one eye in 61.5% of blind people, with refractive error responsible for another 10%.', 'CONCLUSIONS: Despite the increased attention given to eye care in Doumen County, blindness remains a major public health problem.'], ['BACKGROUND: Age-related macular degeneration (ARMD) is the most prevalent cause of blindness in the elderly population.'], ['Age-related macular degeneration (AMD) is a heterogeneous group of disorders and is the leading cause of blindness in the elderly.'], ['Ocular findings characteristic of CP include conjunctival cicatrization, subepithelial fibrosis, and symblepharon formation, which may progress to blindness.'], ['In Canada, glaucoma is the second leading cause of blindness in people aged 50 and over, with primary open-angle glaucoma (POAG) accounting for 90% of all cases.'], ['AIM: To determine the level of correct knowledge about common eye disease and attitudes towards blindness prevention and treatment, and how these factors influence self care practices in a population based sample.', 'A subsample of the population was also asked questions to determine their attitudes to blindness prevention and treatment.', 'Younger people believed blindness prevention and blindness treatment were the highest priorities compared with other diseases; people who spoke English at home and people with knowledge of common age related eye disease also considered blindness treatment to be the highest priority compared with other diseases.'], ['Age-related macular degeneration, a major cause of blindness for which no satisfactory treatments exist, leads to a gradual decrease in central high acuity vision.'], ['PURPOSE: To estimate the prevalence of blindness and cataract surgery among older adults in rural China.', 'Cataract was the principal cause of blindness in at least one eye in 48.2% (67/139) of blind people.', 'CONCLUSIONS: Blindness, particularly blindness related to cataract, continues to be a significant problem among the elderly, especially women, in this population-based sample of rural Chinese.'], ['Retinal dystrophies are a heterogeneous group of diseases in which the retina degenerates, leading to either partial or complete blindness.', 'Patients with RP present with narrowing visual fields and night blindness, while those with diseases of the macula lose central vision first.'], ['CONCLUSIONS: This new noninvasive optical method will facilitate studies of ocular carotenoid distributions and their role in degenerative diseases of the eye and may allow for the rapid screening of carotenoid levels in large populations at risk for vision loss from age-related macular degeneration, the leading cause of blindness in the elderly in the United States.'], ['RESULTS: The prevalence of blindness, according to World Health Organization criteria, ranged from 0.1% in subjects aged 55 to 64 years to 3.9% in subjects aged 85 years or older; the prevalence of visual impairment ranged from 0.1% to 11.8%.', 'For persons aged 75 years or older, age-related macular degeneration was the major cause of the increased prevalence of blindness, whereas age-related cataract predominantly caused the increased prevalence of visual impairment.', 'CONCLUSIONS: The hierarchy of causes of blindness and visual impairment is highly determined by age.', 'As yet, little can be done to reduce the exponential increase of blindness; however, adequate implementation of surgery to treat cataract could reduce visual impairment by one third.'], ['BACKGROUND: Age-related macular degeneration (AMD), the leading cause of irreversible blindness and low vision among the elderly, has not been well studied with regard to its impact on daily life.', 'PARTICIPANTS: The study sample consisted of 86 elderly adults (average age, 79 years) with AMD who were legally blind in at least 1 eye.', 'CONCLUSIONS: Elderly persons with AMD causing legal blindness in 1 or both eyes have significant emotional distress and profoundly reduced quality of life and need help with key daily activities.'], ['Barriers to performing CPR centred around legalities and disease transmission.'], ['This case report describes the use of a motorized wheelchair and guide dog by a legally blind patient with severe visual loss due to oculocutaneous albinism.'], ['Ageing is associated with loss of bone tissue, reduction in muscle mass, reduced respiratory function, decline in cognitive function, rise in blood pressure and macular degeneration which predispose to disabling conditions such as osteoporosis, heart disease, dementia and blindness.'], ['Health promotion and disease prevention activities directed at cardiovascular disease may help reduce the rate of AMD-associated blindness among older people.'], ['The chronobiotic effects of melatonin in humans have been mainly studied in circadian rhythm sleep disorders related to jet lag, shift work, blindness or aging.'], ['The study demonstrates clearly the fact that blindness prevalence increases with age and highlights the causes of blindness and low vision in this population.'], ['Paranoid delusional disorder was found to be commoner among females, a third of those having had similar disorder in the past, and was associated with partial blindness and partial deafness.'], ['The prevalence of low vision was 32% while that of blindness was 12.2%.'], ['However, Aboriginal Australians have rates of blindness comparable to Third World countries.', "These data are compared with results for 'blindness' and 'poor vision' from a national survey undertaken in 1976.", "There was a decline in 'poor vision' between surveys (OR = 2.86; 1.86-4.75) but not in 'blindness'."], ['OBJECTIVE: The study was conducted to determine the prevalence rates of blindness and visual impairment in those aged 60 years and above in Singapore and to determine the pickup rate of undiagnosed eye diseases through an active screening programme.'], ['All studies were evaluated on the use of a placebo control, monotherapy, and double blindness.'], ['The present paper studied the influence of long lasting blindness on processes of aging.'], ['PURPOSE: To describe the age-specific and gender-specific rates of blindness and visual impairment in urban adults aged 40 years and older.', 'Age-adjusted rates of blindness were 0.066% in men and 0.170% in women.', 'CONCLUSIONS: Although overall rates of blindness because of visual acuity loss were relatively low, nearly three times more people had visual impairment because of visual field loss than visual acuity loss.', 'These results highlight the need to target blindness prevention programs to the aging population, with a special emphasis on women.'], ['AIMS/BACKGROUND: The late stages of age-related maculopathy (ARM), especially neovascular macular degeneration (ARMD), can severely affect central vision and are the main cause of blindness in the elderly in the Western world.'], ['UNLABELLED: Despite age-related macular degeneration (AMD) being the commonest cause of blindness amongst the elderly in Western society, the incidence of new lesions is poorly documented and the natural history of existing disease remains ill understood.'], ['Despite this, there remains a paucity of quality data concerning the population prevalence of AMD, the commonest cause of blindness in the elderly.'], ['These conditions are the leading causes of blindness among infants, those of working age and the elderly, respectively.'], ['The occurrence of blindness (visual acuity < or = 0.1) and moderate visual impairment (visual acuity 0.2-0.4) was assessed.', 'The study revealed a low incidence of blindness, which is in line with recent reports.'], ['In preparation for the planning of a regional prevention of blindness programme, a population-based survey of blindness and eye disease was conducted in two provinces (Diyarbakir and Mardin) of southeast Turkey.', 'The prevalence of blindness (best vision poorer than 3/60) was 0.4%, and an estimated 1.5% had low vision (best vision poorer than 6/18, but not blind).', 'Compared to the blindness prevalence of 0.2% in the European Economic Community (EEC), the age-standardised prevalence of blindness in southeast Turkey was 8 times as high.', 'The main causes of blindness in the sample were cataract (50%), corneal opacity (15%), glaucoma (12%), phthisis (6%) and optic atrophy (6%).', 'The survey findings suggest that as the age structure of the regional population approaches that of the EEC through the "ageing trend\', a four-fold increase in the burden of blindness might be expected, unless improvements are made in curative and preventive ophthalmic services in parallel with the general development that improves survival.'], ['Age-related macular degeneration (AMD) is the most common cause of blindness in Australia, rising in prevalence from zero in people aged under 55 years to 18.5% in those aged over 85 years.'], ['BACKGROUND: Accurate data on the prevalence of blindness in urban populations is not readily available.'], ['RESULTS: Cataract and macular degeneration were the most common causes of monocular and binocular blindness.', 'The prevalence of monocular and binocular blindness in South Australia in the population aged 50 and over is calculated to be approximately 3.7% and 1.3%, respectively.'], ['BACKGROUND: Age-related macular degeneration (ARMD) is the leading cause of legal blindness in the elderly, causing profound loss of central vision.'], ['CONCLUSIONS: Clinical expressivity of Wagner disease varies from unaffected carriers to bilateral blindness.'], ['Age-related macular degeneration (ARMD), the most common form of the disease, is the leading cause of legal blindness in the elderly population in the United States and in the many developed countries throughout the world.'], ['BACKGROUND: Primary open-angle glaucoma (POAG) is one of the three leading causes of blindness in Australia, often causing considerable visual field loss before the patient becomes symptomatic.'], ['BACKGROUND: Age-related maculopathy (ARM) is the most common cause of blindness in the elderly in the western world.'], ['The expansion of IOL surgery for unilateral blindness is a favourable trend in ensuring financial sustainability of delivery systems; patients can be operated on while still economically productive and able to pay rather than waiting for bilateral blindness and a less favourable economic and social impact.'], ['Furthermore, it may be involved in the events that trigger the changes leading to age-related macular degeneration (AMD), the leading cause of untreatable blindness in the elderly.'], ['The program involves learners in a variety of ethical and legal dilemmas that centers around a patient, her family, and a variety of health care professionals.', 'The interactive program invites viewers to explore the complex ethical and legal dilemmas involved in making life-and-death decisions about her care.'], ['Data on onchocercal lymphatic and skin lesions from 45 communities located in the West African savanna were analysed to determine if the criterion for inclusion in ivermectin mass treatment based on risk of onchocercal blindness needs to be modified.', 'Other lymphatic lesions were almost exclusively found in people older than 30 years living in villages at risk of onchocercal blindness.', 'Permanent skin lesions also affected older people and were 3 times more frequent in villages at risk of onchocercal blindness.', 'No evidence was, therefore, found to change the criterion based on risk of onchocercal blindness presently in use in savanna areas.'], ['OUTCOMES: Delay or prevention of visual deterioration or blindness.'], ['A person has "low vision" when legally blind or partially sighted.'], ['OBJECTIVE--To evaluate the relationships between dietary intake of carotenoids and vitamins A, C, and E and the risk of neovascular age-related macular degeneration (AMD), the leading cause of irreversible blindness among adults.'], ['Macular degeneration is a leading cause of blindness and poor vision in the elderly.'], ['Leading causes of blindness in the elderly include age-related macular degeneration, open-angle glaucoma and cataract.'], ['They had a variety of comorbid conditions at the start of CAPD: Retinopathy (5/7), blindness (3/7), hypertension (5/7), peripheral neuropathy (7/7), peripheral vascular disease (3/7), congestive heart failure (3/7), myocardial infarction (1/7), ischemic heart disease (2/7).'], ['BACKGROUND: Age-related macular degeneration (ARMD) is a major cause of blindness in the elderly.'], ['Vitelliform macular dystrophy (Best disease) is an autosomal dominant macular dystrophy which shares important clinical features with age-related macular degeneration, the most common cause of legal blindness in the elderly.'], ['Among the latter, of particular interest to the pediatric population will be the potential application of melatonin treatment in establishing or reestablishing circadian rhythms in infants and children maintained for long periods under artificial light conditions, as encountered in intensive care units, and in the treatment of sleep and other rhythm disorders associated with developmental delay or blindness.'], ['Five patients were legally blind, and three others had severely impaired vision in one eye.'], ['However, taking into account previous estimates by the World Health Organization and adjusting to the world population of 1990, it is likely that there are at least 35 million blind people if we apply the internationally accepted definition of blindness as vision less than 3/60 ( less than 20/400 or 0.05) in the better eye.', 'Corneal blindness, resulting mainly from trachoma and other infections, is apparently showing a downward trend, but there are still foci of severe disease.', 'It should be possible, by targeting ivermectin distribution programs to high-risk populations, to gradually eliminate onchocerciasis as a cause of blindness; however, the long-term sight-saving effect of ivermectin in cases of established ocular lesions needs to be confirmed.'], ['Ethics must also consider professional responsibility and obligation beyond what might be required to meet the legal basis of practice.', 'Simply being "this side of legal" is not adequate in both an ethical and moral sense.'], ["Because patients with Alzheimer's disease are on a path of declining capacity to give consent, advancement of research with Alzheimer's disease subjects presents challenging and perplexing ethical and legal dilemmas."], ['The prevalence of functional blindness increased with age, from 1% at age 71 to 74 years to 17% in those 90 years of age and older.', 'Age and nursing home residence were significantly (P < 0.05) more strongly associated with blindness (odds ratios 4.8 and 6.1, respectively) than they were with visual impairment.'], ['Locating and characterizing the NCMD gene may be an important step in understanding this group of maculopathies as well as age-related macular degeneration (AMD), a common cause of blindness in the elderly.'], ['MAIN OUTCOME MEASURES: Presenting binocular Snellen 6 m distance acuity and best monocular 3 m Sonksen-Silver acuity to classify prevalence of blindness by World Health Organisation criteria (less than 3/60 in better eye) and American criteria for legal blindness (better eye equal to 6/60 or less) and of low vision by WHO criteria (best acuity 6/18) and visual impairment by American criteria (less than 6/12 or 20/40 but greater than 6/60 or 20/200 in better eye).', 'The prevalence of blindness was 1% by WHO criteria and 3.9% by American criteria.'], ['Severe disability is not a contraindication since patients in wheelchairs have mastered the technique despite paraplegia, an anaesthetic perineum, spinal deformity, intention tremor, mental handicap, old age or blindness.'], ['As legal abortions yield prenatal hearts only in very limited numbers, human embryonic and fetal cardiac tissue and cell cultures could also be used for such research under both physiological and pathological conditions, such as hypoxia or simulated ischemia.'], ['The elderly patient with a new headache needs emergency evaluation for temporal arteritis and rapid corticosteroid treatment if the diagnosis is confirmed, to prevent blindness.'], ['We found that the presence of aging macular degeneration was a more important predictor of the outcome of legal blindness than the thickness of the hemorrhage (P = .03).'], ['The Hong Kong 1981 Census found a high prevalence of blindness in the age group aged 65 and above.', 'Visual defects short of blindness are also a special problem among the elderly and cataract is one of the most important causes.'], ['For example, temporal arteritis with resultant blindness is a feared disorder in the elderly.', 'Transient blindness, headaches, jaw claudication, and an elevated Westergren sedimentation rate suggest this diagnosis.'], ["Trachoma is considered the world's leading preventable cause of blindness, with hundreds of millions of people affected and approximately 6 to 9 million blinded as a result of the disease.", 'In some parts of the world, because of demographics, it is likely that there are more people being exposed to trachoma as children and more will survive to old age when trachomatous blindness develops.'], ['We discuss the implications of these disabilities in terms of the challenges to the aging and blindness service delivery systems.'], ['A population based survey of trachoma and blindness was conducted in a rural Nile Delta hamlet.', 'Estimates of blindness based on this survey and other surveys in Egypt indicate that blindness is still a serious public health problem in rural Egypt.', 'The current crude blindness rate of 1.8% is expected to increase to 2.3% in the year 2000 and to 3.2% in 2020.'], ['The risk of blindness is ten times greater for those over age 65 than for younger individuals.'], ['Partial or complete blindness may occur in patients with either giant cell arteritis or polymyalgia rheumatica, often appearing rapidly after cessation of corticosteroid therapy or rapid reduction of dosage.'], ['It will also be an important factor in the prevention of blindness in Asian nations.'], ['Cataract is one of the major causes of blindness, and it is estimated that over 50,000,000 people suffer from this disability.'], ['In the present study, the causes of blindness were distributed as follows: glaucoma was the only cause in 25%; cataract was one of the causes in 66% and macular degeneration in 24%.'], ['Age-related Macular Degeneration (AMD) is responsible for the majority of registered blindness in the elderly.'], ['The symptoms of polymyalgia rheumatica respond to low-dose corticosteroid therapy, while giant cell arteritis requires higher doses to prevent blindness due to involvement of the temporal artery.'], ['Because loss of sight among the elderly often accompanies other more noticeable afflictions, geriatric blindness is a neglected yet serious problem for many older people.', "As the nation's population grows older, it will be imperative that heretofore separate systems coordinate their efforts to address what the author predicts will be a concomitant increase in geriatric blindness."], ['The following basic metaphors are presented through case material: glaucoma as an accompaniment of aging, as blindness, as pressure, as an abstraction (and a weapon), and as fate.'], ['A small proportion of cases remain resistant to conservative treatment; blind condylotomy (surgical sectioning) of the affected condylar neck is a safe, effective procedure for refractory cases which do not respond to the conservative regimen described.'], ['We have described a case of sudden blindness of the right eye in an 81-year-old white woman with a one-month history of increasingly severe jaw claudication and a normal Westergren sedimentation rate.', 'Isolated jaw claudication in the elderly is of diagnostic importance, and the need for temporal artery biopsy and rapid institution of high-dose steroid therapy to prevent blindness is emphasized.'], ['Published clinic and hospital data, population-based surveys and World Health Organization estimates indicate that 1.2% of the entire population of Africa is blind, and that cataract causes 36% of this blindness.', 'Ocular disease and ophthalmic manpower status questionnaires mailed to every African country in 1982 by the International Eye Foundation support these contentions, and further demonstrate that cataract is the biggest single cause of blindness on the continent.', 'As this form of blindness is so closely related to aging, an estimate of the annual incidence of the condition can be made.'], ['The number of persons eligible because of age declined 9 percent, from 823,000 to 745,000; persons eligible because of blindness increased 1 percent, from 41,000 to 42,000; and persons eligible because of disability increased 1 percent, from 1,076,000 to 1,086,000.'], ['The visual capacity of persons still remaining in the district 1980 was largely independent of all efforts to prevent blindness from glaucoma in the present population.'], ['The ocular disease distribution and causes of blindness in the Navajo Indians are discussed.', 'Trauma, usually associated with alcohol ingestion, is the most common cause of monocular blindness.', 'Corneal scars, glaucoma, and retinal detachment are the other leading causes of blindness.'], ['It is suggested that, if these were carried out, many glaucoma patients would be discovered amongst the elderly population and with effective treatment ophthalmologists would have progressed a long way towards the aim of preventing blindness occurring from this disease.'], ['Corticosteroid therapy should be started promptly in high doses in order to prevent blindness.'], ['A high index of suspicion and frequent testing of the ESR in elderly patients with vague complaints may lead to earlier diagnosis and appropriate therapy and thus may prevent blindness and even death.'], ['It is important to establish the diagnosis of temporal arteritis because the disease is treatable; treatment may prevent blindness and even death.'], ['Cataract, the leading cause of blindness in the United States, chiefly affects the elderly.'], ['Involvement of the eye may produce minimal scarring or permanent blindness.'], ['Age-related macular degeneration (AMD), the leading cause of blindness in elderly populations, involves the loss of central vision due to progressive dysfunction of the retinal pigment epithelium (RPE) and subsequent loss of light-sensing photoreceptors.'], ['Age-related macular degeneration AMD is one of the leading causes of blindness in the elderly population.'], ['Age-related macular degeneration (AMD) is an eye disease, which causes impaired vision that can lead to blindness.'], ['Cataract was the leading cause of blindness 54.1%, followed by refractive error (21.6%), glaucoma (11.7%), and corneal opacities (5.4%).'], ['Background: Glaucoma is the predominant cause of irreversible blindness, particularly the late presentation.', 'Family history of blindness, presenting IOP, type of glaucoma and age were independently associated with late presentation.', 'Patients with family history of blindness had late advanced glaucoma five times higher than those with no family history of blindness.', 'Conclusions: Presence of family history of blindness, high presenting intraocular pressure, pseudoexfoliative glaucoma and old age are risk factors for late presentation of glaucoma.'], ['Human organoids could facilitate research of complex and currently incurable neuropathologies, such as age-related macular degeneration (AMD) which causes blindness.'], ['ENGLISH SUMMARY: Age-related macular degeneration (AMD) is the most common cause of irreversible vision loss and blindness in high-income countries.'], ['Age-related cataract (ARC) is the common cause of blindness globally.'], ['Age-related macular degeneration (AMD), the leading cause of blindness in the elderly, is characterized by the death of retinal pigment epithelium (RPE) and photoreceptors.'], ['Cataract is the leading cause of blindness worldwide and surgery is the only option to treat the disease.'], ['However, conventional injection methods, such as percutaneous injections using a needle, can cause severe complications, such as skin necrosis or blindness due to intravascular injections.'], ['Age-related macular degeneration (AMD) causes legal blindness in older adults worldwide.', 'Deposition of these lipids leads to soft drusen and basal linear deposit (BLinD), a thin layer of soft drusen material in AMD; Pre-BLinD is the precursor.', 'Both ASHS-LIA and pre-BLinD/BLinD accumulate in older adults and start under the macula; 2.', 'ASHS-LIA shares hypofluorescence with soft drusen, known to be physically continuous with pre-BLinD/BLinD.', 'Neither ASHS-LIA nor pre-BLinD/ BLinD are visible by multimodal imaging anchored on current optical coherence tomography, as confirmed with direct clinicopathologic correlation.'], ['Vision is vital for daily activities, and yet the most common eye diseases-cataracts, DR, ARMD, and glaucoma-lead to blindness in aging eyes.'], ['Older adults are at high risk for VI and blindness.', 'Objective: To present updated national epidemiological estimates of VI and blindness in older US adults based on objective visual function testing.'], ['The alpha-crystallin small heat shock proteins contribute to the transparency and refractive properties of the vertebrate eye lens and prevent the protein aggregation that would otherwise produce lens cataracts, the leading cause of human blindness.'], ['94 million people are blind or visually impaired globally, and cataract is the most common cause of blindness worldwide.', 'However, most cases of blindness are avoidable.'], ['CONCLUSION: We conclude that both policymakers and research should overcome their peripheral blindness by learning from and supporting creativity at the margins in future policies and research.'], ['RESULTS: Around 34% of population had low vision (male:30% and female: 38%), while blindness prevalence was 1.63% (males: 1.88% and females: 1.41%).', 'The unadjusted odds of falls were 16% higher among individuals with low vision and 40% higher among individuals with blindness than with normal vision, and comparatively higher odds among females than males.'], ['VI was determined using vision impairment, low vision, and blindness codes (ICD-9-CM, ICD-10-CM).'], ['These data show that although the prevalence rates of vision loss and blindness are decreasing around the world, the actual number of people affected is slowly increasing.'], ['Glaucoma is a leading cause of irreversible blindness worldwide and is characterized by progressive loss of visual function and retinal ganglion cells (RGC).'], ['To fill this gap, here we report data from a cross-sectional study in which a large sample of young and elderly participants (160 participants in total) who were congenitally blind (long-term visual deprivation), adventitiously blind (late onset of blindness), blindfolded sighted (short-term visual deprivation) and sighted (full visual availability) performed a spatial memory task that required egocentric/allocentric distance judgements with regard to memorised stimuli.'], ['Cataract, the leading cause of blindness worldwide, is caused by crystallin protein aggregation within the protected lens environment.'], ['Diabetic retinopathy (DR) is a leading cause of blindness worldwide and a costly complication of diabetes mellitus (DM).'], ['In addition, specialized authors indicate Michelangelo showed some of the neurological symptoms of this disease (blindness in old age, depression, and fever).'], ['Age-related macular degeneration (AMD) is one of the leading causes of irreversible blindness in the elderly population.'], ['Visual acuity worse than 20/60 and 20/400 in the better eye was regarded as low vision and blindness, respectively.', 'RESULTS: According to presenting visual acuity, VI was found in 14.8% (95%CI: 13.1-16.5) of the participants, including low vision in 13.8% (95%CI: 12.2-15.4) and blindness in 1.1% (95%CI: 0.5-1.6).', 'Multivariable logistic regression analysis showed that older age (OR = 1.07(per year)), lower education level (illiterate versus college: OR = 3.55), and lower economic status (middle versus rich: OR = 1.30 and poor versus rich; OR = 1.72) had a significant relationship with an increase in the prevalence of VI, and older age (OR = 1.14(Per year increase)) and diabetes (OR = 2.62) had a significant relationship with blindness.', 'However, cataract (48.3%) was the leading cause of blindness.'], ['In patients with diabetes, atherosclerosis is the main reason for impaired life expectancy, and diabetic nephropathy and retinopathy are the largest contributors to end-stage renal disease and blindness, respectively.'], ['Diabetic retinopathy (DR), age-related macular degeneration (AMD), and glaucoma are the 3 most common causes of irreversible blindness on a global scale.'], ['Loss of human OPA1 leads to dominant optic atrophy, a mitochondrial disease leading to childhood onset blindness.'], ['RESULTS: The model predicts that for every 1000 patients treated with troglitazone, the improved glycemic control could mean that 95 to 140 fewer patients would experience one of the most severe diabetic complications (eg, blindness, end-stage renal disease, amputation), which may increase life expectancy by 2.0 years.'], ['RESULTS: Nonproliferative retinopathy, proliferative retinopathy, and macular edema are predicted in 79, 19, and 52%, respectively, of people with NIDDM; 19% are predicted to develop legal blindness.'], ['AIM: To estimate rates of progression and to asssess the projected lifetime risk of blindness among treated eyes of juvenile-onset primary open glaucoma (JOAG) patients.', 'METHODS: Rates of change of the visual field index of JOAG patients (diagnosed between the age of 10-40 years), with at least 5 year follow up, were used to estimate the lifetime risk of perimetric blindness.', 'Average life expectancy of the population was used to calculate the lifetime risk of perimetric blindness.', 'The projected risk of bilateral blindness among JOAG patients over their lifetime was 10%.', 'CONCLUSIONS: Though the rate of visual field deterioration with treatment, among juvenile glaucoma patients is lower compared to that among other types of primary glaucoma, the projected lifetime risk of perimetric blindness in these eyes is similar, despite the longer duration of disease in this age group.'], ['Osteopetrosis leads to bone marrow failure and blindness due to optic nerve compression.', 'CONCLUSION: Low-dose busulphan conditioning and neonatal SCT leads to prolonged survival of oc/oc mice, reverses osteopetrosis and prevents blindness even at low engraftment levels.'], ['Markov states comprised first-line to fourth-line pharmacological treatments, no treatment, laser therapy, surgery, blindness, and death.', 'First-line or second-line drugs best at controlling intraocular pressure (IOP) reduced laser therapy, surgery, and the prevalence of blindness.'], ['Life expectancy in patients with amaurosis fugax was reduced.', 'Comparing our results to those published for cerebral transient ischaemic attacks, patients with amaurosis fugax have a similar mortality rate but probably have a lower incidence of stroke.', 'Patients with amaurosis fugax who have an occluded or narrowed proximal internal carotid artery have a greater risk of subsequent stroke than those with a normal carotid artery, or an arteriogram (p less than 0.01).'], ['PURPOSE: Cataract and glaucoma are among the leading causes of blindness worldwide in older people, and they are often concomitant.'], ['INTRODUCTION: The neuronal ceroid lipofuscinoses (NCLs) are a subset of lysosomal storage diseases (LSDs) that cause myoclonic epilepsy, loss of cognitive and motor function, degeneration of the retina leading to blindness, and early death.'], ['Leber congenital amaurosis (LCA) associated with retinal pigment epithelium-specific protein 65 kDa (RPE65) mutations is a severe hereditary blindness resulting from both dysfunction and degeneration of photoreceptors.'], ['As antiretroviral therapy makes its way to these countries, however, both life expectancy and the prevalence of blindness related to HIV/AIDS can be expected to increase dramatically.'], ['Though minor vascular occlusions are not uncommon, cases of blindness secondary to facial filler injections are thought to be rare.'], ['The higher mortality rate among the visually impaired suggests that, in this environment, blindness is not only associated with considerable disability but is also associated with a shortened life expectancy, especially for women.'], ['In a second stepping task, participants experienced sudden anterior balance loss in a lean-and-release protocol.'], ['The ocular infection is the major cause of corneal blindness in the Western World.'], ['People with diabetes are at increased risk for blindness, lower extremity amputation, kidney failure, nerve disease, hypertension, ischemic heart disease and stroke.'], ['Critically, visual cortex synchrony was no higher in adult-onset blind than sighted blindfolded participants and did not increase with blindness duration.'], ['Reducing visual impairment and blindness in children in resource-poor countries is one of the key components of the major global prevention of blindness initiative, VISION 2020 the Right to Sight.', 'Much has changed in the past 10-20 years and there is a need to reassess both the magnitude and causes of global childhood blindness and visual impairment.', 'While the widespread implementation of vitamin A supplementation and measles immunisation programmes have led to a reduction in vitamin A deficiency-related blindness in many poor countries, retinopathy of prematurity is now undergoing a third wave of endemicity, particularly in newly industrialising countries in Latin America and Asia.', 'A programmatic approach with a multidisciplinary team is essential to reducing childhood blindness.'], ['Cataract was the cause of 40% of the ocular morbidity and also caused 57% of the blindness.'], ['In addition to end-stage renal disease (ESRD), DM is associated with blindness, accelerated atherosclerosis, dyslipidemia, cardio- and cerebrovascular disease, amputation, poor quality of life, and overall lifespan reduction.'], ['Glucose metabolism impairment is common in thalassaemic patients and early recognition is mandatory because long-term complication can have a detrimental impact on QOL (as blindness or dialysis).'], ['With the introduction of national diabetes eye screening programmes, the prevalence of blindness in working-age adults is falling.'], ['PURPOSE: To assess the impact of 2 strategies for initiating therapy in ocular hypertension (OH) on drug use, intraocular pressure (IOP), and blindness caused by glaucoma.', 'The difference between strategies was 2 days spent in blindness per patient.'], ['PURPOSE: More than 90% of blindness worldwide exists in the developing world, but information on the social and economic burden and the cost-effectiveness of treatment in these settings is often limited or nonexistent.'], ['CONCLUSIONS: Whereas previous reports of the MSCIS data have identified the life expectancies associated with a particular set of demographic (eg, age, gender) and injury-related characteristics (level and completeness of injury; ventilator dependence), the current analysis suggests that consideration of health, economic, and psychosocial factors may make computations of life expectancy more accurate.'], ['Brugia malayi is a human filarial nematode responsible for elephantiasis, a debilitating condition that is part of a broader spectrum of diseases called filariasis, including lymphatic filariasis and river blindness.'], ['Vision loss and blindness are potential complications of leprosy.', 'We sought to determine the relative risk of death in blind leprosy patients compared to nonblind leprosy patients.', 'Young blind leprosy patients had the highest relative risk of death.', 'Excess mortality was not associated with any specific cause of blindness, ocular pathology, or type of disease.'], ['Usher syndrome (USH) is the leading cause of combined deafness and blindness, with USH2A being the most prevalent form.'], ['BACKGROUND: Diabetic retinopathy (DR) has become a leading cause of global blindness as a microvascular complication of diabetes.'], ['A 45-year-old laborer presented with a several year history of episodic bilateral blindness and a more recent onset of "drop attacks."'], ['The estimated current life expectancy, compared with the general British population, ranged from 18.1 to 88.4% depending on the ventilator dependency, level and completeness of injury, age and gender.'], ['The aims of this study were to investigate prior rates of VF loss in patients attending for trabeculectomy and to estimate, in the absence of surgical intervention, lifetime risk of visual impairment, and blindness.', 'Given Scottish life expectancy data, untreated, 61 eyes (52%) would have passed the threshold for visual impairment, whereas 40 (34%) would have passed the threshold demarcating blindness.'], ['Persons with diabetes had 3 times greater odds of blindness.'], ['On the other hand, the increasing life expectancy in developing countries spirals age-related blindness.', 'Human immunodeficiency virus and blindness are both associated with discrimination, stigma and long-term consequences.'], ['Here, using a combination of uni- and multivoxel analyses applied to fMRI data, we extend our previous findings, comprehensively investigating how early and late acquired blindness impact on the cortical regions coding for the deprived and the remaining senses.', 'We additionally show that blindness does not affect the encoding of the acoustic properties of our sounds (e.g.'], ['PURPOSE: To estimate the prevalence of blindness and cataract surgical outcomes in persons 50 years or older above in Takeo Province, Cambodia.', 'The age- and sex-adjusted prevalence of bilateral blindness [presenting visual acuity (PVA) <3/60 in the better eye] was 3.4% (95% confidence interval, 2.8%-4.0%), resulting in an estimated 4187 people blind in Takeo Province.', 'The increased life expectancy in Cambodia and the fact that women constitute 60.6% of the population (aged >=50 years) at Takeo Province could have had an impact on cataract workload and high prevalence of blindness.'], ['BACKGROUND: Cataract is the major cause of global blindness, accounting for 40 to 80% of all blindness in developing countries.'], ['RESULTS: The addition of screening for microalbuminuria and retinopathy followed by appropriate treatment, if detected, were cost saving, with reduction in cumulative incidence of end stage renal disease and blindness respectively, and, in the case of microalbulminuria screening and treatment, an improvement in life expectancy.'], ['By manipulating various arms of the immune response of experimental hosts, we show that filarial nematodes, the parasites responsible for debilitating diseases in humans like river blindness and elephantiasis, accelerate their development in response to the IL-5 driven eosinophilia they encounter when infecting a host.'], ['RESULTS: The key factors related to long-term survival were age, time since injury, neurologic level, and degree of completeness of injury.'], ['Whereas short term effects - decreased learning and food security, and increased anxiety, violence against children, child labor and teen pregnancies - are frequently discussed, the long-term effects of school closures will be much more detrimental across the lifespan of the "Generation Corona": Existing pandemics of inactivity and myopia, already affecting billions of people, are worsening due to less physical exercise and less time spent outdoors, poor diet, weight gain, and increased screen time during lockdowns, causing future increases of stroke, heart attack, cancer, and blindness.'], ['BACKGROUND: Uncontrolled trachoma is a leading cause of blindness.', 'Current global trachoma burden summary measures are presented as disability adjusted life years but have limitations due to inconsistent methods and inadequate population-based data on trachomatous low vision and blindness.', 'TTLE was broken down by VA to derive TTLE with normal vision, TTLE with low vision, and TTLE with blindness.', 'Trichiasis life expectancy with low vision or blindness was 5.1 (95% CI = 3.9-6.4) years (9% [95% CI = 7-11] of remaining life) and 7.6 (95% CI = 6.0-9.1) years (12% [95% CI = 10-15] of remaining life) for males and females, respectively.', 'Women were predicted to live longer and spend a greater proportion of their lives with disabling trichiasis, low vision, and blindness compared to men.', 'CONCLUSIONS: The study shows the future burden associated with doing nothing to control trachoma in Southern Sudan, that is, a substantial proportion of remaining life expectancy spent with trichiasis and low vision or blindness for both men and women, with a disproportionate burden falling on women.'], ['Eye injuries from blunt forces, penetrating objects, burns, or irritating substances cause morbidity, disability, and blindness worldwide.'], ['AS is an autosomal recessive disorder causing early blindness, progressive sensorineural hearing loss, cardiomyopathy, endocrine disorders, metabolic dysfunction, and abbreviated lifespan.'], ['The proportion of patients projected to progress to visual impairment (MD: -14 dB or worse) or statutory blindness (MD: -22 dB or worse) in both eyes before end of expected lifetime was calculated.', 'Of those patients with both eyes followed, 5.2% (CI 4.5%-6.0%) were predicted to progress to statutory blindness, with a further 10.4% (CI 9.4%-11.4%) reaching visual impairment in their lifetime.', 'More than 90% (CI 85.7%-94.3%) of patients predicted to progress to statutory blindness, had an MD worse than -6 dB in at least one eye at presentation.', 'CONCLUSIONS: This modeling exercise indicates that most patients in glaucoma clinics are not at high risk of progressing to statutory blindness.'], ['DHPG, a new virustatic for human cytomegalovirus, appears promising as treatment for the severe CMV-retinitis, which leads rapidly to blindness.'], ['Glaucoma is the second cause of blindness, resulting from a slow and progressive loss of retinal ganglion cells (RGCs) and their axons.'], ['BACKGROUND/AIMS: Cataract is the leading cause of blindness in leprosy patients.'], ['Neurologic sequelae include cranial nerve compression (optic nerve, blindness; auditory nerve, deafness; facial nerve, paresis), hydrocephalus, convulsions, and mental retardation.'], ['Age-related macular degeneration (AMD) is one of the leading causes of blindness worldwide with increasing prevalence owing to increased life expectancy.'], ['Lower-extremity amputation (LEA) risk was based on the type 1 diabetes Swedish inpatient registry, and the risk of blindness was obtained from results of a German-based study.', 'CONCLUSIONS: The model incorporates diabetic complications risk data from a type 1 diabetes population and synthesizes other type 1-specific data to estimate long-term outcomes of CVD, end-stage renal disease, LEA and risk of blindness, along with life expectancy and QALYs.'], ['To estimate the long-term incidence and associated risk factors of blindness (Paper II) and cataract surgery (Paper III) in type 1 diabetes.', 'As demonstrated in Paper II, blindness is an important issue in type 1 diabetes.', 'The 25-year cumulative incidence of blindness was 7.5%.', 'Glycaemic regulation and maculopathy at baseline were both identified as risk factors of blindness.', 'Overall, it was demonstrated that various complications such as mortality, blindness and cataract surgery were high in type 1 diabetes.'], ['PURPOSE: To report the 6-year incidence, causes and risk factors for vision loss (visual impairment (VI) and blindness), among elderly adults in rural southern China.', 'The WHO categories of vision loss were used to define incident cases of VI (3/60<=VA <6/12), moderate-to-severe VI (MSVI) (3/60<=VA<6/18) and blindness (VA <3/60) in the better-seeing eye.', 'Based on presenting and best-corrected VA, respectively, the crude incidence rate of blindness was 0.8% (95% CI 0.5% to 1.1%) vs 0.3% (95% CI 0.1% to 0.5%), for MSVI 6.7% (95% CI 5.7% to 7.6%) vs 4.6% (95% CI 3.8% to 5.4%) and for any VI 16.1% (95% CI 14.5% to 17.6%) vs 12.9% (95% CI 11.6% to 14.1%).'], ['Although cord blood transplantation has significantly extended the lifespan of mucopolysaccharidosis type 1 (MPS1) patients, over 95% manifest cornea clouding with about 50% progressing to blindness.', 'As corneal transplants are met with high rejection rates in MPS1 children, there remains no treatment to prevent blindness or restore vision in MPS1 children.', 'Since MPS1 is caused by mutations in idua, which encodes alpha-L-iduronidase, a gene addition strategy to prevent, and potentially reverse, MPS1-associated corneal blindness was investigated.', 'The collective preclinical data demonstrate safe and efficient IDUA delivery to human corneas, which may prevent and potentially reverse MPS1-associated cornea blindness.'], ['OBJECTIVE: People with diabetes who have chronically higher than normal blood glucose levels are at risk for a variety of health conditions, such as kidney failure, blindness, amputation, and a shortened life expectancy.'], ['In contrast, Sumf1 null mice with complete deficiency in all sulfatase enzyme activities, have very short lifespan with significant pre-wean lethality, owing to a challenging preclinical model.'], ['Patient preferences/utilities showed significant variation: blindness 0.39 (SD, 0.32), lower leg amputation 0.45 (0.34), conventional treatment 0.76 (0.27), and intensive insulin treatment 0.64 (0.32).'], ['One of the most important challenges for modern medicine is the fact of a worldwide increase of diabetic long-term complications such as kidney failure, coronary and peripheral vascular disease, blindness and neuropathy.'], ['Declines were noted in rates of blindness, diabetes-related end-stage kidney disease, lower limbs amputations and diabetes-related mortality.'], ['AIMS: To provide population-based data on the maximum tolerable rate of progression to avoid visual impairment (maxTRoP_VI) and blindness (maxTRoP_BL) from open-angle glaucoma (OAG).', 'Visual impairment was defined as mean deviation (MD) equal to or worse than -12dB and blindness as MD equal to or worse than -24dB.'], ['It is of clinical significance to determine the risk of blindness and its causes to prevent its occurrence.', 'A considerable number of glaucoma patients were found to be blind at the end of their life; with up to 24% unilateral and 10% bilateral blindness.', 'The following factors were associated with blindness: (1) baseline severity of visual field loss: advanced stage of glaucoma or substantial visual field loss at the initial visit; (2) factors influencing progression: fluctuation of intraocular pressure (IOP) during treatment, presence of pseudoexfoliation, poor patient compliance, higher IOP; (3) longer time period: longer duration of disease and older age at death because of a longer life expectancy; and (4) coexistence of other ocular pathology.', 'CONCLUSIONS: Further prevention of blindness in glaucoma patients is needed.', 'To reach this goal, it is important to address the risk factors for blindness identified in this review, especially those that can be modified, such as advanced disease at diagnosis, high and fluctuating IOP, and poor compliance.'], ['Eleven of the studies used the rapid assessment of avoidable blindness (RAAB) method and four used the rapid assessment of cataract surgical services (RACSS) method.'], ["Since the original informed consent did not cover postmortem use of the husband's sperm, a special application for its use was made and subsequently approved by the Israeli Ministry of Health legal advisor."], ['eclampsia, altered mental status, blindness, stroke, clonus, severe headaches, and persistent visual scotomata); or hematological complications (thrombocytopenia-platelet count <150 000/muL, disseminated intravascular coagulation, hemolysis); or3.Uteroplacental dysfunction (such as fetal growth restriction, abnormal umbilical artery Doppler waveform analysis, or stillbirth).It is well established that a number of maternal risk factors are associated with the development of PE: advanced maternal age; nulliparity; previous history of PE; short and long interpregnancy interval; use of assisted reproductive technologies; family history of PE; obesity; Afro-Caribbean and South Asian racial origin; co-morbid medical conditions including hyperglycemia in pregnancy; pre-existing chronic hypertension; renal disease; and autoimmune diseases, such as systemic lupus erythematosus and antiphospholipid syndrome.'], ['Probabilities for development of end stage renal disease (ESRD), blindness, mortality, and direct health care costs were taken from the literature.'], ['This program could be highly effective in preventing blindness in First Nations diabetic patients in British Columbia through early intervention in diabetic retinopathy.'], ['NCLs are distinct lysosomal storage disorders (LSDs) sharing various hallmarks, namely accumulation of protein aggregates and ceroid lipofuscin leading to neurodegeneration and blindness.'], ['Results of the model were expressed as the duration of low vision (worse eye VA>1.0 and better eye VA>0.7 logMAR) and blindness (bilateral VA >1.0 logMAR).', 'Health consequences of blindness and low vision were estimated for depression, hip fractures, institutionalization, and life expectancy.', 'RESULTS: For AMD patients with a 50% probability of VA >1.0 logMAR at 1 year, in one eye, the probability of lifetime bilateral blindness was >47%.', 'The patients would live approximately 7 years with monocular vision >1.0 logMAR and an additional 4 years with bilateral blindness and a >15% probability of depression due to AMD.'], ['The natural history of medically treated patients with cholesterol emboli is compared both with an age and sex matched population and with patients with amaurosis fugax but no visible retinal emboli.'], ['Hypertension is a silent disease that causes increase in cardiovascular, cerebrovascular, renal morbidity and mortality whereas diabetic complications cause heart attack, stroke, blindness and kidney disease.'], ['In nursing homes in Flanders, the rate of CSD has tripled over the past decade, whereas legal euthanasia remains a rare practice.', 'In some cases, CSD can even be considered a substitute for legal euthanasia.'], ['SCD can affect virtually every vascular bed in the eye and can cause blindness in the advanced stages.'], ['The associated complications of diabetes, such as cardiovascular disease, peripheral vascular disease, stroke, diabetic neuropathy, amputations, renal failure, and blindness result in increasing disability, reduced life expectancy, and enormous health costs.'], ['Genetic mutations that disrupt the proper function of the rod circuit contribute to blinding diseases including retinitis pigmentosa and congenital stationary night blindness (CSNB).'], ['Glaucoma is the leading cause of irreversible blindness worldwide, currently affecting around 80 million people.']]
numbers of articles: 723
JT: ['Medicina (Kaunas, Lithuania)', 'International journal of molecular sciences', 'Computers in biology and medicine', 'The Journal of pathology', 'Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society', 'International ophthalmology', 'BMC ophthalmology', 'Proceedings of the National Academy of Sciences of the United States of America', 'Frontiers in immunology', 'Free radical biology & medicine', 'Acta ophthalmologica', 'Cells', 'Scientific reports', 'Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie', 'Nigerian journal of clinical practice', 'Asian journal of psychiatry', 'International ophthalmology', 'Aging cell', 'Advances in clinical and experimental medicine : official organ Wroclaw Medical University', 'International journal of molecular sciences', 'Journal of immunology research', 'International journal of molecular sciences', 'Nature communications', 'BMC public health', 'Clinical interventions in aging', 'The American journal of pathology', 'The Medical clinics of North America', 'International journal of molecular sciences', 'Advances in experimental medicine and biology', "Journal of women's health (2002)", 'British journal of pharmacology', 'Cellular and molecular life sciences : CMLS', 'The Lancet. Global health', 'Investigative ophthalmology & visual science', 'Trials', 'Asia-Pacific journal of public health', 'International journal of molecular sciences', 'PloS one', 'Drugs & aging', 'Cortex; a journal devoted to the study of the nervous system and behavior', 'Investigative ophthalmology & visual science', 'American journal of ophthalmology', 'Stem cell research & therapy', 'The Lancet. Global health', 'The Lancet. Public health', 'International journal of molecular sciences', 'Genes', 'PLoS neglected tropical diseases', 'Journal of controlled release : official journal of the Controlled Release Society', 'Journal of molecular medicine (Berlin, Germany)', 'Nutrients', 'Disability and rehabilitation', 'Journal of glaucoma', 'Journal of geriatric psychiatry and neurology', 'Medwave', 'Asia-Pacific journal of clinical oncology', 'Oxidative medicine and cellular longevity', 'Scientific reports', 'Nature reviews. Rheumatology', 'The Journal of biological chemistry', 'Human molecular genetics', 'Molecular genetics & genomic medicine', 'Ophthalmic epidemiology', 'African journal of primary health care & family medicine', 'Redox biology', 'Medicine', 'Proceedings of the National Academy of Sciences of the United States of America', 'Rheumatology (Oxford, England)', 'Frontiers in immunology', 'Expert opinion on pharmacotherapy', 'Expert opinion on therapeutic targets', 'Molecular therapy : the journal of the American Society of Gene Therapy', 'Current aging science', 'Ophthalmic epidemiology', 'Survey of ophthalmology', 'Biomedical physics & engineering express', 'American journal of ophthalmology', 'Nature communications', 'International journal of environmental research and public health', 'Journal of vascular surgery', 'Aging', 'International journal of molecular sciences', 'Journal of neurophysiology', 'Oxidative medicine and cellular longevity', 'Experimental gerontology', 'Bioscience reports', 'Clinical and experimental pharmacology & physiology', 'F1000Research', "Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie", 'Prion', 'International journal of medical sciences', 'Medicina (Kaunas, Lithuania)', 'BMJ open', 'Current environmental health reports', 'International journal of environmental research and public health', 'Nepalese journal of ophthalmology : a biannual peer-reviewed academic journal of the Nepal Ophthalmic Society : NEPJOPH', 'FEBS open bio', 'PloS one', 'Ophthalmic surgery, lasers & imaging retina', "Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie", 'Free radical biology & medicine', "Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie", 'JAMA ophthalmology', 'International journal of molecular sciences', 'EBioMedicine', 'Diseases of the colon and rectum', 'JAMA ophthalmology', 'Scientific reports', 'Ophthalmic epidemiology', 'The American journal of pathology', 'American journal of rhinology & allergy', 'JCI insight', 'Journal of cell science', 'IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society', 'Journal of global health', 'PloS one', 'EBioMedicine', 'International journal of molecular medicine', 'Acta ophthalmologica', 'BMC health services research', 'JCI insight', 'Eye (London, England)', 'Journal of translational medicine', 'Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation', 'Nature communications', 'Toxicology letters', 'Advanced drug delivery reviews', 'Journal of global health', 'Journal of global health', 'Lipids in health and disease', 'JAMA facial plastic surgery', 'Investigative ophthalmology & visual science', 'Current neuropharmacology', 'Scientific reports', 'Medical hypotheses', 'Danish medical journal', 'Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference', 'Expert opinion on biological therapy', 'JAMA ophthalmology', 'Pharmacoepidemiology and drug safety', 'BMC ophthalmology', 'BMC ophthalmology', 'International journal of medical sciences', 'The Lancet. Global health', 'Molecular medicine reports', 'General and comparative endocrinology', 'Seminars in ophthalmology', 'Mitochondrion', 'JAMA ophthalmology', 'Oncotarget', 'Progress in retinal and eye research', 'Human mutation', 'International psychogeriatrics', 'BioMed research international', 'Scientific reports', 'EMBO molecular medicine', 'Annual review of pathology', 'Investigative ophthalmology & visual science', 'Investigative ophthalmology & visual science', 'Disability and rehabilitation', 'Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research', 'Ophthalmic genetics', 'Diabetes care', 'Experimental eye research', 'Journal of visualized experiments : JoVE', 'The Cochrane database of systematic reviews', 'Human molecular genetics', 'The British journal of ophthalmology', 'Experimental eye research', 'Journal of physiology and biochemistry', 'Anatomical record (Hoboken, N.J. : 2007)', 'Pharmacology & therapeutics', 'Asia-Pacific journal of ophthalmology (Philadelphia, Pa.)', 'JAMA ophthalmology', 'South Dakota medicine : the journal of the South Dakota State Medical Association', 'Biochimica et biophysica acta', 'Methods in molecular biology (Clifton, N.J.)', 'Experimental eye research', 'Journal of tissue engineering and regenerative medicine', 'Annals of global health', 'BMJ clinical evidence', 'Ophthalmic genetics', 'Molecular vision', 'Journal of clinical nursing', 'Seminars in ophthalmology', 'Molecular medicine reports', 'Scientific reports', 'The Cochrane database of systematic reviews', 'Experimental eye research', 'The journals of gerontology. Series B, Psychological sciences and social sciences', 'Diabetes research and clinical practice', 'International journal of clinical and experimental pathology', 'Journal of geriatric psychiatry and neurology', 'PloS one', 'Advances in clinical and experimental medicine : official organ Wroclaw Medical University', 'Middle East African journal of ophthalmology', 'Nature genetics', 'Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology', 'Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]', 'PloS one', 'Maturitas', 'The Veterinary clinics of North America. Small animal practice', 'Human reproduction (Oxford, England)', 'Rural and remote health', 'Experimental eye research', 'Advances in experimental medicine and biology', 'Aging clinical and experimental research', 'Ophthalmology', 'Experimental eye research', 'The journal of gene medicine', 'Ageing research reviews', 'Primary care', 'Journal of cosmetic dermatology', 'PloS one', 'Investigative ophthalmology & visual science', 'Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG', 'Nature communications', 'AIDS patient care and STDs', 'Drugs & aging', 'Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology', 'Acta ophthalmologica', 'Progress in retinal and eye research', 'Neurobiology of disease', 'JAMA ophthalmology', 'Psychological research', 'Oncotarget', 'Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis', 'PloS one', 'Neuropsychology review', 'Antioxidants & redox signaling', 'Contemporary clinical trials', 'PLoS neglected tropical diseases', 'The Cochrane database of systematic reviews', 'BMC medicine', 'Aging', 'Brain research', 'Stem cells translational medicine', 'The British journal of ophthalmology', 'Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS)', 'Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS)', 'Stem cells translational medicine', 'Cell death & disease', 'Annals of plastic surgery', 'PharmacoEconomics', 'Psychological research', 'PloS one', 'Optometry and vision science : official publication of the American Academy of Optometry', 'Progress in retinal and eye research', 'Current diabetes reviews', 'PloS one', 'Clinical interventions in aging', 'Gene therapy', 'The British journal of ophthalmology', 'Cerebral cortex (New York, N.Y. : 1991)', 'The British journal of ophthalmology', 'Clinical and experimental rheumatology', 'BMC ophthalmology', 'Mediators of inflammation', 'Investigative ophthalmology & visual science', 'Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi', 'Investigative ophthalmology & visual science', 'Investigative ophthalmology & visual science', 'Anaesthesia', 'Progress in retinal and eye research', 'PloS one', 'The Journal of biological chemistry', 'ASN neuro', 'Current eye research', 'PloS one', 'PloS one', 'DNA and cell biology', 'Antioxidants & redox signaling', 'Ophthalmic epidemiology', 'Collegium antropologicum', 'Clinical & experimental optometry', 'Boletin de la Asociacion Medica de Puerto Rico', 'Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi', 'Cytokine', 'Acta ophthalmologica', 'Stem cells translational medicine', 'Advances in nutrition (Bethesda, Md.)', 'Ophthalmic genetics', 'Proceedings of the National Academy of Sciences of the United States of America', 'Disability and rehabilitation', 'Journal of clinical nursing', 'PloS one', 'PloS one', 'Mediators of inflammation', 'PloS one', 'Cell reports', 'PloS one', 'Japanese journal of ophthalmology', 'Journal of neurosurgery', 'Deutsches Arzteblatt international', 'Neuron', 'Molecular vision', 'Investigative ophthalmology & visual science', 'Eye (London, England)', 'Investigative ophthalmology & visual science', 'Molecular aspects of medicine', 'Experimental eye research', 'Experimental and molecular pathology', 'Menopause (New York, N.Y.)', 'Investigative ophthalmology & visual science', 'Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery', 'Journal of cell science', 'Ophthalmic epidemiology', 'Recent patents on endocrine, metabolic & immune drug discovery', 'West African journal of medicine', 'West African journal of medicine', 'Rejuvenation research', 'Clinical & experimental ophthalmology', 'Inflammation', 'Proceedings of the National Academy of Sciences of the United States of America', 'Experimental eye research', 'Journal of the National Medical Association', 'Medical science monitor : international medical journal of experimental and clinical research', 'Photochemistry and photobiology', 'PloS one', 'The British journal of ophthalmology', 'Geriatrics & gerontology international', 'BMJ clinical evidence', 'PloS one', 'Stem cells (Dayton, Ohio)', 'The journal of nutrition, health & aging', 'The Tohoku journal of experimental medicine', 'Philosophical transactions of the Royal Society of London. Series B, Biological sciences', 'PloS one', 'Psychology and aging', 'Clinical chemistry and laboratory medicine', 'Current opinion in ophthalmology', 'Investigative ophthalmology & visual science', 'Archives of pharmacal research', 'American journal of therapeutics', 'Laboratory investigation; a journal of technical methods and pathology', 'Clinical & experimental optometry', 'Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics', 'Ophthalmic epidemiology', 'Vision research', 'Journal of medical systems', 'Vision research', 'Ophthalmic epidemiology', 'Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics', 'Ophthalmic genetics', 'Journal of the Medical Association of Thailand = Chotmaihet thangphaet', 'Ophthalmology', 'Journal of biomechanical engineering', 'PloS one', 'Progress in retinal and eye research', 'Experimental eye research', 'Journal of the American College of Nutrition', 'Investigative ophthalmology & visual science', 'Ophthalmic epidemiology', 'American journal of ophthalmology', 'Drugs & aging', 'Ophthalmic epidemiology', 'Current eye research', 'Deutsches Arzteblatt international', 'Clinics in geriatric medicine', 'Experimental gerontology', 'Geriatrics & gerontology international', 'Acta ophthalmologica', 'Current opinion in clinical nutrition and metabolic care', 'Nepalese journal of ophthalmology : a biannual peer-reviewed academic journal of the Nepal Ophthalmic Society : NEPJOPH', 'Current opinion in ophthalmology', 'Journal of molecular biology', 'Molecular & cellular proteomics : MCP', 'Clinical interventions in aging', 'Developments in ophthalmology', 'Biochimica et biophysica acta', 'Tanzania journal of health research', 'American journal of epidemiology', 'American journal of clinical dermatology', 'Annals of the Royal College of Surgeons of England', 'Biochemistry', 'Ophthalmic epidemiology', 'Molecular vision', 'Internal medicine journal', 'Optometry (St. Louis, Mo.)', 'Ophthalmic epidemiology', 'Journal of clinical and experimental neuropsychology', 'Clinical & experimental optometry', 'Experimental eye research', 'The international journal of cardiovascular imaging', 'Ophthalmic epidemiology', 'Experimental gerontology', 'Experimental eye research', 'The journals of gerontology. Series A, Biological sciences and medical sciences', 'Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions', "Canadian journal of ophthalmology. Journal canadien d'ophtalmologie", 'Nutrition reviews', 'PloS one', 'Eye (London, England)', 'Annals of the New York Academy of Sciences', 'Eye (London, England)', 'Medicine and health, Rhode Island', 'The Journal of biological chemistry', 'PLoS medicine', 'Indian journal of leprosy', 'Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation', 'Trends in amplification', 'Experimental eye research', 'The Journal of pharmacology and experimental therapeutics', 'European journal of human genetics : EJHG', 'The journal of ECT', 'Ophthalmology', 'Acta crystallographica. Section F, Structural biology and crystallization communications', 'Postgraduate medical journal', 'British journal of nursing (Mark Allen Publishing)', 'Ophthalmology', 'Investigative ophthalmology & visual science', 'Indian journal of ophthalmology', 'Experimental eye research', 'Journal of the Indian Medical Association', 'BMJ clinical evidence', 'European journal of ophthalmology', 'Ophthalmic genetics', 'Annals of medicine', 'Investigative ophthalmology & visual science', 'The Cochrane database of systematic reviews', 'Retina (Philadelphia, Pa.)', "Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde", 'European journal of ophthalmology', 'Ophthalmology', 'Investigative ophthalmology & visual science', 'Ophthalmic epidemiology', 'Human heredity', 'Circulation journal : official journal of the Japanese Circulation Society', 'The Journal of biological chemistry', 'Clinical & experimental ophthalmology', 'Current drug discovery technologies', 'Human genetics', 'Journal of diabetes and its complications', 'Cancer causes & control : CCC', 'Drug and therapeutics bulletin', 'Indian journal of ophthalmology', 'Aging clinical and experimental research', 'International psychogeriatrics', "Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde", 'Clinics (Sao Paulo, Brazil)', 'Medical hypotheses', 'FEBS letters', 'Expert reviews in molecular medicine', 'Clinical & experimental optometry', 'American journal of ophthalmology', 'Transactions of the Royal Society of Tropical Medicine and Hygiene', 'Archives of physical medicine and rehabilitation', 'Applied spectroscopy', 'The British journal of ophthalmology', 'Progress in retinal and eye research', 'Archives of physical medicine and rehabilitation', 'Neurobiology of aging', 'Proceedings of the National Academy of Sciences of the United States of America', 'Progress in retinal and eye research', 'Japanese journal of ophthalmology', 'The British journal of ophthalmology', 'Investigative ophthalmology & visual science', 'The American journal of pathology', 'Biochimie', 'Croatian medical journal', 'Clinical & experimental ophthalmology', 'Expert opinion on investigational drugs', 'Rehabilitation nursing : the official journal of the Association of Rehabilitation Nurses', 'Aging clinical and experimental research', 'The Journal of biological chemistry', 'The Southeast Asian journal of tropical medicine and public health', 'Archives of ophthalmology (Chicago, Ill. : 1960)', 'Journal of clinical pharmacology', 'Brain research bulletin', 'Expert opinion on pharmacotherapy', 'Journal of agromedicine', 'Hospital medicine (London, England : 1998)', 'Journal of biomedical optics', 'Journal of biomedical optics', 'Ophthalmology', 'Optometry (St. Louis, Mo.)', 'Current opinion in cell biology', 'Ophthalmic epidemiology', 'The International journal of social psychiatry', 'Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs', 'Singapore medical journal', 'Experimental eye research', 'Investigative ophthalmology & visual science', 'Drugs & aging', 'Ophthalmology', 'Clinical & experimental ophthalmology', 'Clinical & experimental ophthalmology', 'Nature reviews. Drug discovery', 'The American journal of emergency medicine', 'The British journal of ophthalmology', 'International journal of toxicology', 'Ophthalmic epidemiology', 'Journal of the Indian Medical Association', 'The British journal of ophthalmology', 'The British journal of ophthalmology', 'Biochemical and biophysical research communications', 'The British journal of ophthalmology', 'Expert opinion on pharmacotherapy', 'Ophthalmology clinics of North America', 'Journal of the Optical Society of America. A, Optics, image science, and vision', 'The British journal of ophthalmology', 'Tropical medicine & international health : TM & IH', 'Experimental eye research', 'Clinical excellence for nurse practitioners : the international journal of NPACE', 'The British journal of ophthalmology', 'Journal of applied physiology (Bethesda, Md. : 1985)', 'American journal of therapeutics', 'Human gene therapy', 'Documenta ophthalmologica. Advances in ophthalmology', "Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie", 'Federal register', 'Nagoya journal of medical science', 'Indian journal of ophthalmology', 'Ophthalmology', 'Ophthalmology', 'Bulletin of the World Health Organization', 'Experimental eye research', 'Clinical & experimental ophthalmology', 'Ophthalmic epidemiology', 'International journal of geriatric psychiatry', 'Ophthalmology', "International journal of fertility and women's medicine", 'Medicine', 'Journal of psychiatric and mental health nursing', 'The Journal of biological chemistry', 'Seminars in ophthalmology', 'International ophthalmology clinics', 'Journal of epidemiology and community health', 'Diabetes/metabolism research and reviews', 'Federal register', 'Ophthalmology', 'Zhonghua yi xue za zhi = Chinese medical journal; Free China ed', "Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde", 'Cutis', 'Chronic diseases in Canada', 'The British journal of ophthalmology', 'Proceedings of the National Academy of Sciences of the United States of America', 'American journal of ophthalmology', 'Eye (London, England)', 'Investigative ophthalmology & visual science', 'Archives of ophthalmology (Chicago, Ill. : 1960)', 'Archives of ophthalmology (Chicago, Ill. : 1960)', 'The Canadian journal of cardiology', 'Archives of physical medicine and rehabilitation', 'Philosophical transactions of the Royal Society of London. Series B, Biological sciences', 'Journal of the American Geriatrics Society', 'Clinical neuropharmacology', 'East African medical journal', 'West African journal of medicine', 'Indian journal of ophthalmology', 'Australian and New Zealand journal of ophthalmology', 'Singapore medical journal', 'Stroke', 'Perceptual and motor skills', 'American journal of ophthalmology', 'The British journal of ophthalmology', 'Eye (London, England)', 'Eye (London, England)', 'Ophthalmic research', 'Acta ophthalmologica Scandinavica', 'Ophthalmic epidemiology', 'The Medical journal of Australia', 'Australian and New Zealand journal of ophthalmology', 'Ophthalmic epidemiology', 'Journal of the American Optometric Association', 'Ophthalmology', 'Survey of ophthalmology', 'Australian and New Zealand journal of ophthalmology', 'Laboratory investigation; a journal of technical methods and pathology', 'Bulletin of the World Health Organization', 'Gerontology', 'Medinfo. MEDINFO', 'Transactions of the Royal Society of Tropical Medicine and Hygiene', "CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne", 'Geriatrics', 'JAMA', 'Kansas medicine : the journal of the Kansas Medical Society', 'Journal of community health', 'Clinical nephrology', 'Journal of the American Optometric Association', 'American journal of human genetics', 'The Journal of pediatrics', 'JAMA', 'Current opinion in ophthalmology', 'Clinics in podiatric medicine and surgery', 'Journal of the American Geriatrics Society', 'Ophthalmology', 'Genomics', 'BMJ (Clinical research ed.)', 'The British journal of general practice : the journal of the Royal College of General Practitioners', 'Therapie', 'Drugs & aging', 'American journal of ophthalmology', 'Singapore medical journal', 'Emergency medicine clinics of North America', 'Scandinavian journal of infectious diseases. Supplementum', 'The Gerontologist', 'The British journal of ophthalmology', 'Ophthalmology', 'Drugs', 'Japanese journal of ophthalmology', 'Free radical biology & medicine', 'Acta ophthalmologica. Supplement', 'Eye (London, England)', 'Postgraduate medicine', 'Health & social work', 'Culture, medicine and psychiatry', 'International dental journal', 'Southern medical journal', 'Social science & medicine (1982)', 'Social security bulletin', 'Acta ophthalmologica', 'Annals of ophthalmology', 'Current medical research and opinion', 'American heart journal', 'Postgraduate medicine', 'Documenta ophthalmologica. Advances in ophthalmology', 'Journal of the American Geriatrics Society', 'Cutis', 'Oxidative medicine and cellular longevity', 'Biomolecules', 'Acta ophthalmologica', 'African health sciences', 'Ethiopian journal of health sciences', 'Nature communications', 'Acta ophthalmologica', 'Oxidative medicine and cellular longevity', 'Cells', 'Ageing research reviews', 'Clinical anatomy (New York, N.Y.)', 'Eye (London, England)', 'International journal of molecular sciences', 'JAMA ophthalmology', 'Experimental eye research', 'Lancet (London, England)', 'Health policy (Amsterdam, Netherlands)', 'BMC public health', 'Disability and health journal', 'Eye (London, England)', 'Cellular and molecular neurobiology', 'Quarterly journal of experimental psychology (2006)', 'Scientific reports', 'Experimental gerontology', 'Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology', 'Translational research : the journal of laboratory and clinical medicine', 'Ophthalmic epidemiology', 'Cell metabolism', 'Asia-Pacific journal of ophthalmology (Philadelphia, Pa.)', 'Current biology : CB', 'Clinical therapeutics', 'Diabetes care', 'Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists)', 'Experimental hematology', 'Journal of glaucoma', 'Journal of neurology, neurosurgery, and psychiatry', 'European journal of ophthalmology', 'Expert opinion on biological therapy', 'Proceedings of the National Academy of Sciences of the United States of America', 'Bulletin of the World Health Organization', 'Current opinion in ophthalmology', 'Bulletin of the World Health Organization', 'Human movement science', 'Current medicinal chemistry', 'The American journal of the medical sciences', 'Neuropsychologia', 'Archives of disease in childhood', 'Nigerian journal of medicine : journal of the National Association of Resident Doctors of Nigeria', 'Transplantation', 'Endocrine, metabolic & immune disorders drug targets', 'The lancet. Diabetes & endocrinology', 'Journal of glaucoma', 'Optometry and vision science : official publication of the American Academy of Optometry', 'Archives of physical medicine and rehabilitation', 'PLoS neglected tropical diseases', 'Leprosy review', 'Communications biology', 'BMC health services research', 'Annals of vascular surgery', 'Spinal cord', 'Eye (London, England)', 'BMC public health', 'Indian journal of ophthalmology', 'eLife', 'Asia-Pacific journal of ophthalmology (Philadelphia, Pa.)', 'The Cochrane database of systematic reviews', 'Diabetologia', 'PLoS biology', 'The journal of spinal cord medicine', 'Trends in neuroscience and education', 'PLoS neglected tropical diseases', 'International journal of nursing studies', 'Disability and rehabilitation', 'Investigative ophthalmology & visual science', 'Documenta ophthalmologica. Advances in ophthalmology', 'Progress in neurobiology', 'The British journal of ophthalmology', 'Clinical orthopaedics and related research', 'Survey of ophthalmology', 'PharmacoEconomics', 'Acta ophthalmologica', 'The British journal of ophthalmology', 'Scientific reports', 'Quality management in health care', 'Journal of inherited metabolic disease', 'Medical care', 'Experimental and clinical endocrinology', 'Israel journal of health policy research', 'The British journal of ophthalmology', 'Journal of glaucoma', 'Revista panamericana de salud publica = Pan American journal of public health', 'Journal of assisted reproduction and genetics', 'International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics', 'Transplantation', 'International journal of circumpolar health', 'Autophagy', 'Investigative ophthalmology & visual science', 'Journal of neurology, neurosurgery, and psychiatry', 'African journal of traditional, complementary, and alternative medicines : AJTCAM', 'Journal of the American Medical Directors Association', 'Annals of tropical paediatrics', 'American journal of therapeutics', 'PloS one', 'Translational vision science & technology']
TA: ['Medicina (Kaunas)', 'Int J Mol Sci', 'Comput Biol Med', 'J Pathol', 'J Neuroophthalmol', 'Int Ophthalmol', 'BMC Ophthalmol', 'Proc Natl Acad Sci U S A', 'Front Immunol', 'Free Radic Biol Med', 'Acta Ophthalmol', 'Cells', 'Sci Rep', 'Biomed Pharmacother', 'Niger J Clin Pract', 'Asian J Psychiatr', 'Int Ophthalmol', 'Aging Cell', 'Adv Clin Exp Med', 'Int J Mol Sci', 'J Immunol Res', 'Int J Mol Sci', 'Nat Commun', 'BMC Public Health', 'Clin Interv Aging', 'Am J Pathol', 'Med Clin North Am', 'Int J Mol Sci', 'Adv Exp Med Biol', 'J Womens Health (Larchmt)', 'Br J Pharmacol', 'Cell Mol Life Sci', 'Lancet Glob Health', 'Invest Ophthalmol Vis Sci', 'Trials', 'Asia Pac J Public Health', 'Int J Mol Sci', 'PLoS One', 'Drugs Aging', 'Cortex', 'Invest Ophthalmol Vis Sci', 'Am J Ophthalmol', 'Stem Cell Res Ther', 'Lancet Glob Health', 'Lancet Public Health', 'Int J Mol Sci', 'Genes (Basel)', 'PLoS Negl Trop Dis', 'J Control Release', 'J Mol Med (Berl)', 'Nutrients', 'Disabil Rehabil', 'J Glaucoma', 'J Geriatr Psychiatry Neurol', 'Medwave', 'Asia Pac J Clin Oncol', 'Oxid Med Cell Longev', 'Sci Rep', 'Nat Rev Rheumatol', 'J Biol Chem', 'Hum Mol Genet', 'Mol Genet Genomic Med', 'Ophthalmic Epidemiol', 'Afr J Prim Health Care Fam Med', 'Redox Biol', 'Medicine (Baltimore)', 'Proc Natl Acad Sci U S A', 'Rheumatology (Oxford)', 'Front Immunol', 'Expert Opin Pharmacother', 'Expert Opin Ther Targets', 'Mol Ther', 'Curr Aging Sci', 'Ophthalmic Epidemiol', 'Surv Ophthalmol', 'Biomed Phys Eng Express', 'Am J Ophthalmol', 'Nat Commun', 'Int J Environ Res Public Health', 'J Vasc Surg', 'Aging (Albany NY)', 'Int J Mol Sci', 'J Neurophysiol', 'Oxid Med Cell Longev', 'Exp Gerontol', 'Biosci Rep', 'Clin Exp Pharmacol Physiol', 'F1000Res', 'Graefes Arch Clin Exp Ophthalmol', 'Prion', 'Int J Med Sci', 'Medicina (Kaunas)', 'BMJ Open', 'Curr Environ Health Rep', 'Int J Environ Res Public Health', 'Nepal J Ophthalmol', 'FEBS Open Bio', 'PLoS One', 'Ophthalmic Surg Lasers Imaging Retina', 'Graefes Arch Clin Exp Ophthalmol', 'Free Radic Biol Med', 'Graefes Arch Clin Exp Ophthalmol', 'JAMA Ophthalmol', 'Int J Mol Sci', 'EBioMedicine', 'Dis Colon Rectum', 'JAMA Ophthalmol', 'Sci Rep', 'Ophthalmic Epidemiol', 'Am J Pathol', 'Am J Rhinol Allergy', 'JCI Insight', 'J Cell Sci', 'IEEE Trans Neural Syst Rehabil Eng', 'J Glob Health', 'PLoS One', 'EBioMedicine', 'Int J Mol Med', 'Acta Ophthalmol', 'BMC Health Serv Res', 'JCI Insight', 'Eye (Lond)', 'J Transl Med', 'Exp Clin Transplant', 'Nat Commun', 'Toxicol Lett', 'Adv Drug Deliv Rev', 'J Glob Health', 'J Glob Health', 'Lipids Health Dis', 'JAMA Facial Plast Surg', 'Invest Ophthalmol Vis Sci', 'Curr Neuropharmacol', 'Sci Rep', 'Med Hypotheses', 'Dan Med J', 'Annu Int Conf IEEE Eng Med Biol Soc', 'Expert Opin Biol Ther', 'JAMA Ophthalmol', 'Pharmacoepidemiol Drug Saf', 'BMC Ophthalmol', 'BMC Ophthalmol', 'Int J Med Sci', 'Lancet Glob Health', 'Mol Med Rep', 'Gen Comp Endocrinol', 'Semin Ophthalmol', 'Mitochondrion', 'JAMA Ophthalmol', 'Oncotarget', 'Prog Retin Eye Res', 'Hum Mutat', 'Int Psychogeriatr', 'Biomed Res Int', 'Sci Rep', 'EMBO Mol Med', 'Annu Rev Pathol', 'Invest Ophthalmol Vis Sci', 'Invest Ophthalmol Vis Sci', 'Disabil Rehabil', 'Value Health', 'Ophthalmic Genet', 'Diabetes Care', 'Exp Eye Res', 'J Vis Exp', 'Cochrane Database Syst Rev', 'Hum Mol Genet', 'Br J Ophthalmol', 'Exp Eye Res', 'J Physiol Biochem', 'Anat Rec (Hoboken)', 'Pharmacol Ther', 'Asia Pac J Ophthalmol (Phila)', 'JAMA Ophthalmol', 'S D Med', 'Biochim Biophys Acta', 'Methods Mol Biol', 'Exp Eye Res', 'J Tissue Eng Regen Med', 'Ann Glob Health', 'BMJ Clin Evid', 'Ophthalmic Genet', 'Mol Vis', 'J Clin Nurs', 'Semin Ophthalmol', 'Mol Med Rep', 'Sci Rep', 'Cochrane Database Syst Rev', 'Exp Eye Res', 'J Gerontol B Psychol Sci Soc Sci', 'Diabetes Res Clin Pract', 'Int J Clin Exp Pathol', 'J Geriatr Psychiatry Neurol', 'PLoS One', 'Adv Clin Exp Med', 'Middle East Afr J Ophthalmol', 'Nat Genet', 'Photochem Photobiol Sci', 'Dermatol Surg', 'PLoS One', 'Maturitas', 'Vet Clin North Am Small Anim Pract', 'Hum Reprod', 'Rural Remote Health', 'Exp Eye Res', 'Adv Exp Med Biol', 'Aging Clin Exp Res', 'Ophthalmology', 'Exp Eye Res', 'J Gene Med', 'Ageing Res Rev', 'Prim Care', 'J Cosmet Dermatol', 'PLoS One', 'Invest Ophthalmol Vis Sci', 'Sarcoidosis Vasc Diffuse Lung Dis', 'Nat Commun', 'AIDS Patient Care STDS', 'Drugs Aging', 'Photochem Photobiol Sci', 'Acta Ophthalmol', 'Prog Retin Eye Res', 'Neurobiol Dis', 'JAMA Ophthalmol', 'Psychol Res', 'Oncotarget', 'Perit Dial Int', 'PLoS One', 'Neuropsychol Rev', 'Antioxid Redox Signal', 'Contemp Clin Trials', 'PLoS Negl Trop Dis', 'Cochrane Database Syst Rev', 'BMC Med', 'Aging (Albany NY)', 'Brain Res', 'Stem Cells Transl Med', 'Br J Ophthalmol', 'J Trace Elem Med Biol', 'J Trace Elem Med Biol', 'Stem Cells Transl Med', 'Cell Death Dis', 'Ann Plast Surg', 'Pharmacoeconomics', 'Psychol Res', 'PLoS One', 'Optom Vis Sci', 'Prog Retin Eye Res', 'Curr Diabetes Rev', 'PLoS One', 'Clin Interv Aging', 'Gene Ther', 'Br J Ophthalmol', 'Cereb Cortex', 'Br J Ophthalmol', 'Clin Exp Rheumatol', 'BMC Ophthalmol', 'Mediators Inflamm', 'Invest Ophthalmol Vis Sci', 'Rev Med Chir Soc Med Nat Iasi', 'Invest Ophthalmol Vis Sci', 'Invest Ophthalmol Vis Sci', 'Anaesthesia', 'Prog Retin Eye Res', 'PLoS One', 'J Biol Chem', 'ASN Neuro', 'Curr Eye Res', 'PLoS One', 'PLoS One', 'DNA Cell Biol', 'Antioxid Redox Signal', 'Ophthalmic Epidemiol', 'Coll Antropol', 'Clin Exp Optom', 'Bol Asoc Med P R', 'Rev Med Chir Soc Med Nat Iasi', 'Cytokine', 'Acta Ophthalmol', 'Stem Cells Transl Med', 'Adv Nutr', 'Ophthalmic Genet', 'Proc Natl Acad Sci U S A', 'Disabil Rehabil', 'J Clin Nurs', 'PLoS One', 'PLoS One', 'Mediators Inflamm', 'PLoS One', 'Cell Rep', 'PLoS One', 'Jpn J Ophthalmol', 'J Neurosurg', 'Dtsch Arztebl Int', 'Neuron', 'Mol Vis', 'Invest Ophthalmol Vis Sci', 'Eye (Lond)', 'Invest Ophthalmol Vis Sci', 'Mol Aspects Med', 'Exp Eye Res', 'Exp Mol Pathol', 'Menopause', 'Invest Ophthalmol Vis Sci', 'Otolaryngol Head Neck Surg', 'J Cell Sci', 'Ophthalmic Epidemiol', 'Recent Pat Endocr Metab Immune Drug Discov', 'West Afr J Med', 'West Afr J Med', 'Rejuvenation Res', 'Clin Exp Ophthalmol', 'Inflammation', 'Proc Natl Acad Sci U S A', 'Exp Eye Res', 'J Natl Med Assoc', 'Med Sci Monit', 'Photochem Photobiol', 'PLoS One', 'Br J Ophthalmol', 'Geriatr Gerontol Int', 'BMJ Clin Evid', 'PLoS One', 'Stem Cells', 'J Nutr Health Aging', 'Tohoku J Exp Med', 'Philos Trans R Soc Lond B Biol Sci', 'PLoS One', 'Psychol Aging', 'Clin Chem Lab Med', 'Curr Opin Ophthalmol', 'Invest Ophthalmol Vis Sci', 'Arch Pharm Res', 'Am J Ther', 'Lab Invest', 'Clin Exp Optom', 'J Ocul Pharmacol Ther', 'Ophthalmic Epidemiol', 'Vision Res', 'J Med Syst', 'Vision Res', 'Ophthalmic Epidemiol', 'J Ocul Pharmacol Ther', 'Ophthalmic Genet', 'J Med Assoc Thai', 'Ophthalmology', 'J Biomech Eng', 'PLoS One', 'Prog Retin Eye Res', 'Exp Eye Res', 'J Am Coll Nutr', 'Invest Ophthalmol Vis Sci', 'Ophthalmic Epidemiol', 'Am J Ophthalmol', 'Drugs Aging', 'Ophthalmic Epidemiol', 'Curr Eye Res', 'Dtsch Arztebl Int', 'Clin Geriatr Med', 'Exp Gerontol', 'Geriatr Gerontol Int', 'Acta Ophthalmol', 'Curr Opin Clin Nutr Metab Care', 'Nepal J Ophthalmol', 'Curr Opin Ophthalmol', 'J Mol Biol', 'Mol Cell Proteomics', 'Clin Interv Aging', 'Dev Ophthalmol', 'Biochim Biophys Acta', 'Tanzan J Health Res', 'Am J Epidemiol', 'Am J Clin Dermatol', 'Ann R Coll Surg Engl', 'Biochemistry', 'Ophthalmic Epidemiol', 'Mol Vis', 'Intern Med J', 'Optometry', 'Ophthalmic Epidemiol', 'J Clin Exp Neuropsychol', 'Clin Exp Optom', 'Exp Eye Res', 'Int J Cardiovasc Imaging', 'Ophthalmic Epidemiol', 'Exp Gerontol', 'Exp Eye Res', 'J Gerontol A Biol Sci Med Sci', 'Catheter Cardiovasc Interv', 'Can J Ophthalmol', 'Nutr Rev', 'PLoS One', 'Eye (Lond)', 'Ann N Y Acad Sci', 'Eye (Lond)', 'Med Health R I', 'J Biol Chem', 'PLoS Med', 'Indian J Lepr', 'Qual Life Res', 'Trends Amplif', 'Exp Eye Res', 'J Pharmacol Exp Ther', 'Eur J Hum Genet', 'J ECT', 'Ophthalmology', 'Acta Crystallogr Sect F Struct Biol Cryst Commun', 'Postgrad Med J', 'Br J Nurs', 'Ophthalmology', 'Invest Ophthalmol Vis Sci', 'Indian J Ophthalmol', 'Exp Eye Res', 'J Indian Med Assoc', 'BMJ Clin Evid', 'Eur J Ophthalmol', 'Ophthalmic Genet', 'Ann Med', 'Invest Ophthalmol Vis Sci', 'Cochrane Database Syst Rev', 'Retina', 'Ophthalmologica', 'Eur J Ophthalmol', 'Ophthalmology', 'Invest Ophthalmol Vis Sci', 'Ophthalmic Epidemiol', 'Hum Hered', 'Circ J', 'J Biol Chem', 'Clin Exp Ophthalmol', 'Curr Drug Discov Technol', 'Hum Genet', 'J Diabetes Complications', 'Cancer Causes Control', 'Drug Ther Bull', 'Indian J Ophthalmol', 'Aging Clin Exp Res', 'Int Psychogeriatr', 'Ophthalmologica', 'Clinics (Sao Paulo)', 'Med Hypotheses', 'FEBS Lett', 'Expert Rev Mol Med', 'Clin Exp Optom', 'Am J Ophthalmol', 'Trans R Soc Trop Med Hyg', 'Arch Phys Med Rehabil', 'Appl Spectrosc', 'Br J Ophthalmol', 'Prog Retin Eye Res', 'Arch Phys Med Rehabil', 'Neurobiol Aging', 'Proc Natl Acad Sci U S A', 'Prog Retin Eye Res', 'Jpn J Ophthalmol', 'Br J Ophthalmol', 'Invest Ophthalmol Vis Sci', 'Am J Pathol', 'Biochimie', 'Croat Med J', 'Clin Exp Ophthalmol', 'Expert Opin Investig Drugs', 'Rehabil Nurs', 'Aging Clin Exp Res', 'J Biol Chem', 'Southeast Asian J Trop Med Public Health', 'Arch Ophthalmol', 'J Clin Pharmacol', 'Brain Res Bull', 'Expert Opin Pharmacother', 'J Agromedicine', 'Hosp Med', 'J Biomed Opt', 'J Biomed Opt', 'Ophthalmology', 'Optometry', 'Curr Opin Cell Biol', 'Ophthalmic Epidemiol', 'Int J Soc Psychiatry', 'J Artif Organs', 'Singapore Med J', 'Exp Eye Res', 'Invest Ophthalmol Vis Sci', 'Drugs Aging', 'Ophthalmology', 'Clin Exp Ophthalmol', 'Clin Exp Ophthalmol', 'Nat Rev Drug Discov', 'Am J Emerg Med', 'Br J Ophthalmol', 'Int J Toxicol', 'Ophthalmic Epidemiol', 'J Indian Med Assoc', 'Br J Ophthalmol', 'Br J Ophthalmol', 'Biochem Biophys Res Commun', 'Br J Ophthalmol', 'Expert Opin Pharmacother', 'Ophthalmol Clin North Am', 'J Opt Soc Am A 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IF: [0.0, 5.6, 7.7, 7.3, 0.0, 1.6, 2.0, 11.1, 7.3, 0.0, 3.4, 6.0, 0.0, 7.5, 0.9, 9.5, 1.6, 7.8, 2.1, 5.6, 4.1, 5.6, 16.6, 0.0, 3.6, 6.0, 0.0, 5.6, 0.0, 0.0, 7.3, 8.0, 34.3, 0.0, 2.5, 2.5, 5.6, 3.7, 2.8, 3.6, 0.0, 4.2, 7.5, 34.3, 50.0, 5.6, 3.5, 3.8, 10.8, 0.0, 5.9, 2.2, 2.0, 2.6, 1.2, 1.9, 0.0, 0.0, 33.7, 0.0, 3.5, 2.0, 1.8, 2.0, 11.4, 1.6, 11.1, 0.0, 7.3, 3.2, 5.8, 12.4, 0.0, 1.8, 0.0, 1.4, 4.2, 16.6, 0.0, 4.3, 0.0, 5.6, 2.5, 0.0, 3.9, 4.0, 0.0, 0.0, 0.0, 2.3, 3.6, 0.0, 2.9, 7.9, 0.0, 0.3, 2.6, 3.7, 0.0, 0.0, 0.0, 0.0, 8.1, 5.6, 11.1, 3.9, 8.1, 0.0, 1.8, 6.0, 2.6, 8.0, 4.0, 0.0, 7.2, 3.7, 11.1, 0.0, 3.4, 2.8, 8.0, 0.0, 7.4, 0.9, 16.6, 3.5, 16.1, 7.2, 7.2, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 1.6, 0.0, 0.0, 8.1, 2.6, 2.0, 2.0, 3.6, 34.3, 3.4, 2.7, 1.7, 0.0, 8.1, 0.0, 17.8, 3.9, 7.0, 0.0, 0.0, 11.1, 0.0, 0.0, 0.0, 2.2, 0.0, 1.2, 16.2, 3.4, 0.0, 0.0, 3.5, 0.0, 3.4, 3.4, 0.0, 13.5, 0.0, 8.1, 0.0, 0.0, 0.0, 3.4, 3.3, 2.9, 0.0, 1.2, 2.2, 4.2, 1.7, 3.4, 0.0, 0.0, 3.4, 0.0, 0.0, 1.4, 2.6, 3.7, 2.1, 0.6, 30.8, 0.0, 2.4, 3.7, 0.0, 0.0, 6.1, 2.1, 3.4, 0.0, 4.0, 13.7, 3.4, 3.5, 13.1, 1.9, 2.3, 3.7, 0.0, 0.0, 16.6, 0.0, 2.8, 0.0, 3.4, 17.8, 6.1, 8.1, 0.0, 0.0, 0.0, 3.7, 5.8, 6.6, 2.2, 3.8, 0.0, 9.3, 0.0, 2.9, 6.0, 0.0, 0.0, 0.0, 6.0, 9.0, 1.5, 0.0, 0.0, 3.7, 0.0, 17.8, 3.3, 3.7, 3.6, 0.0, 0.0, 3.7, 0.0, 3.7, 2.0, 0.0, 0.0, 0.0, 0.0, 0.0, 10.7, 17.8, 3.7, 0.0, 0.0, 2.0, 3.7, 3.7, 3.1, 6.6, 1.8, 0.0, 1.9, 0.0, 0.0, 3.8, 3.4, 6.0, 9.3, 1.2, 11.1, 2.2, 4.2, 3.7, 3.7, 0.0, 3.7, 8.8, 3.7, 2.4, 4.1, 7.7, 16.2, 2.2, 0.0, 0.0, 0.0, 10.6, 3.4, 3.6, 2.7, 0.0, 0.0, 4.0, 1.8, 0.0, 0.0, 0.0, 2.6, 4.0, 0.0, 11.1, 3.4, 3.3, 0.0, 3.3, 3.7, 0.0, 3.3, 0.0, 3.7, 0.0, 5.8, 2.2, 0.0, 3.7, 3.7, 6.8, 3.7, 0.0, 6.7, 4.2, 0.0, 1.9, 0.0, 1.8, 1.8, 0.0, 1.8, 1.8, 0.0, 1.2, 0.0, 13.7, 0.0, 3.7, 17.8, 3.4, 3.5, 0.0, 1.8, 4.2, 2.8, 1.8, 2.0, 7.7, 3.3, 3.9, 3.3, 3.4, 3.1, 0.3, 3.7, 5.6, 7.0, 3.6, 0.0, 0.0, 0.0, 0.0, 7.3, 1.4, 2.9, 1.8, 2.2, 2.1, 0.0, 1.8, 2.2, 1.9, 3.4, 0.0, 1.8, 3.9, 3.4, 0.0, 0.0, 4.2, 6.1, 3.7, 0.0, 0.0, 0.0, 0.0, 0.0, 15.8, 0.0, 3.5, 0.0, 3.4, 3.5, 0.0, 2.5, 13.7, 0.0, 0.0, 0.0, 13.7, 0.0, 3.1, 3.4, 0.0, 0.0, 1.7, 1.2, 0.0, 0.0, 0.0, 0.0, 2.6, 1.7, 13.7, 0.0, 1.8, 1.8, 3.3, 0.0, 4.0, 0.0, 0.0, 3.0, 0.0, 0.0, 3.1, 4.0, 7.0, 2.6, 0.0, 0.0, 3.5, 6.2, 1.9, 4.2, 2.2, 0.0, 3.5, 0.0, 17.8, 0.0, 4.2, 11.1, 17.8, 2.4, 0.0, 0.0, 6.0, 3.9, 1.9, 4.0, 6.1, 1.3, 4.0, 0.0, 0.0, 0.0, 2.9, 3.8, 3.2, 2.4, 0.0, 3.5, 3.5, 13.7, 0.0, 7.5, 1.8, 0.0, 1.3, 2.7, 3.4, 0.0, 2.8, 13.7, 4.0, 4.0, 120.1, 3.6, 0.0, 2.2, 1.8, 0.0, 0.0, 0.0, 3.1, 0.0, 3.2, 0.0, 0.0, 0.0, 3.3, 3.4, 0.0, 0.0, 0.0, 4.2, 4.2, 1.4, 0.0, 0.0, 0.9, 3.1, 13.7, 13.7, 11.1, 3.4, 4.0, 1.8, 4.0, 13.7, 0.0, 1.6, 2.7, 0.0, 1.7, 0.0, 6.3, 0.0, 0.0, 13.7, 0.0, 2.6, 1.6, 0.0, 0.0, 11.1, 4.2, 0.0, 0.0, 0.0, 0.0, 6.2, 0.0, 0.0, 6.3, 1.0, 0.0, 0.0, 3.1, 0.0, 2.7, 8.3, 1.6, 4.2, 0.0, 0.0, 0.0, 2.1, 0.0, 1.8, 0.0, 0.0, 1.8, 0.0, 13.7, 0.0, 0.0, 0.0, 11.1, 3.5, 0.0, 2.2, 0.0, 2.3, 0.0, 0.0, 5.9, 1.1, 0.0, 9.8, 0.0, 0.0, 3.7, 0.6, 6.3, 13.7, 0.0, 0.0, 0.0, 2.6, 2.8, 4.2, 2.7, 1.2, 0.0, 5.7, 0.0, 13.7, 11.5, 2.4, 0.0, 0.0, 0.0, 4.2, 1.5, 0.0, 3.3, 1.1, 0.0, 0.0, 3.4, 0.0, 2.3, 0.0, 4.2, 1.4, 6.3, 1.6, 0.0, 5.5, 3.4, 1.0, 1.2, 16.6, 3.4, 0.0, 6.0, 13.1, 2.4, 0.0, 5.6, 8.1, 3.4, 168.9, 3.3, 0.0, 0.0, 0.0, 4.0, 0.0, 0.0, 3.9, 3.3, 7.8, 1.8, 29.0, 0.0, 9.2, 3.2, 16.2, 0.0, 2.6, 2.0, 0.0, 1.7, 0.0, 11.1, 11.1, 3.7, 11.1, 2.1, 4.1, 3.1, 2.6, 0.0, 0.0, 6.2, 0.0, 0.0, 2.0, 0.0, 0.0, 3.8, 0.6, 5.9, 2.8, 1.5, 2.2, 0.0, 0.0, 3.1, 7.7, 0.0, 0.0, 8.2, 9.8, 1.7, 3.3, 3.8, 8.1, 2.2, 0.0, 1.4, 6.7, 0.0, 4.2, 0.0, 0.0, 3.4, 0.0, 0.0, 1.2, 4.2, 3.0, 0.0, 0.0, 0.0, 2.0, 0.0, 3.1, 0.0, 6.2, 1.3, 13.3, 0.0, 0.0, 0.0, 7.6, 0.0, 4.2, 3.7, 3.0]
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alias names:
description: The inability to see or the loss or absence of perception of visual stimuli.
url: https://www.ncbi.nlm.nih.gov/mesh/68001766
mutation position:
mutation alleles:
MeSH ID: D001766
relation: True
external links: []
aging biomarker: False
longevity biomarker: False
target_node = nodes[edge['target entity']]
for k in target_node[0].keys():
print(f"{k}: {target_node[0][k]}")
entity: Neurodegenerative Diseases
type: Disease
PMID: ['35787298', '35776055', '35759428', '35758053', '35757716', '35745150', '35744030', '35740989', '35735245', '35733234', '35729833', '35729173', '35714584', '35691030', '35684455', '35684039', '35682775', '35682821', '35682574', '35678405', '35675251', '35667301', '35659061', '35649653', '35649647', '35640743', '35626698', '35624290', '35618041', '35617280', '35615975', '35608247', '35605511', '35603072', '35585708', '35583896', '35581575', '35577241', '35569721', '35565661', '35563596', '35551622', '35526766', '35527558', '35491249', '35490966', '35488079', '35486397', '35476749', '35469116', '35458696', '35458096', '35456894', '35456994', '35449033', '35447238', '35447046', '35445358', '35440799', '35435938', '35427151', '35426252', '35421316', '35420136', '35419166', '35418416', '35418452', '35413868', '35411565', '35410438', '35410372', '35410065', '35408987', '35408714', '35405260', '35398340', '35397330', '35395956', '35395402', '35390677', '35383335', '35377407', 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official full name: None
sentence: [['Acting as the pacemaker of female physiological aging, ovary is also considered as the principle player of cancer, cardiovascular diseases, cerebrovascular diseases, neurodegenerative diseases and etc.'], ["In this review, we analyzed and reviewed the current status and possible mechanisms between COVID-19 and several typical neurodegenerative diseases, particularly Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis, hoping to propose the potential direction of further research and concern.", "The keywords used were COVID-19, SARS-CoV-2, neurodegenerative disease, Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis.", 'SARS-CoV-2 neuroinvasion, neuroinflammation, and blood-brain barrier (BBB) dysfunction may contribute to the pathogenesis of neurodegenerative diseases.', 'CONCLUSIONS: Some patients with neurodegenerative diseases have already shown more susceptibility to SARS-CoV-2 infection and significantly higher mortality due to the elderly population with underlying diseases.', 'Moreover, SARS-CoV-2 could cause damage to the central nervous system (CNS) that may substantially increase the incidence of neurodegenerative diseases and accelerate the progression of them.'], ['While these new findings warrant replication in larger study samples, the current data contribute to (1) our understanding of the molecular basis of proteomic changes across various age groups in hippocampus subfields in healthy individuals, and (2) the design and interpretation of future research on the age-associated neurodegenerative disorders.'], ['Cellular stress is a major cause of neurodegenerative diseases.'], ['Bi-directional transcription of Human Endogenous Retroviruses (hERVs) is a common feature of autoimmunity, neurodegeneration and cancer.', 'Higher rates of cancer incidence, neurodegeneration and autoimmunity but a lower prevalence of autoimmune diseases characterize elderly people.'], ['Potential mechanisms underpinning the effects of AGEs include elevated oxidative stress and neuroinflammation, which are both key pathogenetic mechanisms underlying neurodegeneration and mental disorders.'], ['Modulation of miRNAs following physical exercise represents an interesting field of investigation since these non-coding RNAs may be considered defenders against degenerative diseases and as well as useful prognostic markers in skeletal and muscle-skeletal diseases, such as osteoporosis.'], ["Alzheimer's disease (AD) is the most prevalent age-associated neurodegenerative disease."], ['The older population is characterised by an increased susceptibility to infections, a poor response to vaccinations, and a higher risk of developing cancer, vascular diseases and neurodegeneration.'], ['In this study, alphaSyn RT-QuIC was used to analyze lumbar CSF in a clinical cohort from the Swedish BioFINDER study and postmortem ventricular CSF in a neuropathological cohort from the Arizona Study of Aging and Neurodegenerative Disorders/Brain and Body Donation Program (AZSAND/BBDP).'], ['Cognitive aging is a major risk factor for neurodegenerative diseases and has a great impact on the living quality of older individuals.'], ['Fractal scaling in animal behavioral activity, where similar temporal patterns appear repeatedly over a series of magnifications among time scales, governs the complex behavior of various animal species and, in humans, can be altered by neurodegenerative diseases and aging.'], ['Recently, it is becoming clear that, beyond such rare inborn errors, the deterioration of peroxisomal functions contributes to multiple and prevalent diseases such as cancer, viral infection, diabetes, and neurodegeneration.'], ["Parkinson's disease (PD) is one of the prevalent neurodegenerative diseases among aging populations.", 'These findings point towards the use of glycitein in the management of neurodegenerative diseases such as PD.'], ['Neurodegenerative diseases (NDDs) are disorders that affect both the central and peripheral nervous systems.', 'The formation of beta-sheet-rich aggregates of intra- or extracellular proteins in the CNS hallmarks all neurodegenerative proteinopathies.'], ['Adherence to different dietary patterns was evaluated using the Mediterranean diet score (MDS), Mediterranean-DASH Diet Intervention for Neurodegenerative Delay (MIND) score, and Alternate Healthy Eating Index-2010 (AHEI).'], ["Alzheimer's disease (AD) is a progressive neurodegenerative disorder and is the most common cause of dementia in older people."], ['Given the skyrocketing global rates of diabetes and neurodegenerative disorders, there is an urgent need to discover novel biomarkers relevant to the co-morbidity of both conditions to guide future diagnostic approaches.'], ['Neurodegenerative diseases are inseparably linked with aging and increase as life expectancy extends.', 'However, most of all, the prominent pathological feature of neurodegenerative diseases is the toxic buildup of misfolded protein aggregates and inclusion bodies accompanied by an impairment in proteostasis.', "The contribution of mutant or misfolded protein-triggered ER stress and its associated signaling events, such as unfolded protein response (UPR), to the pathophysiology of various neurodegenerative disorders, including Alzheimer's, Parkinson's, and Huntington's disease, amyotrophic lateral sclerosis, and prion disease, is described here.", 'Thus, activating certain UPR components has been shown to alleviate ER stress and its associated neurodegeneration.'], ['This article also discusses the underlying proteinopathies of neurodegenerative diseases (eg, amyloid-beta, paired helical filament tau, alpha-synuclein, and TDP-43 pathology) and vascular pathologies, including tissue injury (eg, infarcts, hemorrhages) with or without vessel disease.'], ["Alzheimer's disease (AD) is a progressive neurodegenerative disease affecting cognitive and functional abilities."], ['Biflavones are a kind of natural compound with a variety of biological activities, which have the capability of reversing diabetes and neurodegenerative diseases.'], ['Based on animal model studies, several mechanisms have been proposed to explain such an association, including central insulin signaling, neurodegeneration, brain amyloidosis, and neuroinflammation.', 'Although biomarkers of brain amyloidosis, neurodegeneration and synaptic plasticity are commonly used to diagnose dementia, especially Alzheimer disease, their role in diabetes remains unclear.'], ['Although the exact cellular mechanisms of glucose consumption are still under investigation, 18F-FDG PET can sensitively detect altered neuronal activity due to neurodegeneration.', 'Various neurodegenerative disorders affect different areas of the brain, which can be depicted as altered 18F-FDG uptake by PET.', 'The differentiation of 3 major neurodegenerative disorders by 18F-FDG PET, Alzheimer disease (AD), frontotemporal dementia (FTD), and dementia with Lewy bodies (DLB), has become standard practice.', '18F-FDG PET is a relatively low cost and widely available imaging modality that can help assess various neurodegenerative disorders in a single test and remains the workhorse in clinical dementia evaluation.'], ['For differential diagnostic use, the primary utility of tau PET is to differentiate AD dementia from other neurodegenerative diseases, as is in line with the conditions for the approval of 18F-flortaucipir by the U.S. Food and Drug Administration for clinical use.'], ['Pre-clinical and clinical data suggest that metformin, via suppression of pro-inflammatory pathways, protection of mitochondria and vascular function, and direct actions on neuronal stem cells, may protect against neurodegenerative diseases.'], ['Neurodegenerative diseases are deteriorating conditions of the nervous system that are rapidly increasing in the ageing population.', 'Increasing evidence suggests that neuroinflammation, largely mediated by microglia, the resident immune cells of the brain, contributes to the onset and progression of neurodegenerative diseases.', 'Hence, microglia are considered a major therapeutic target that could potentially yield effective disease-modifying treatments for neurodegenerative diseases.', 'Here, we review the key roles of microglia in neurodegenerative diseases and provide an update on the current microglial plaforms utilised in neurodegenerative diseases, with a focus on human microglia-like cells derived from peripheral blood mononuclear cells as well as human-induced pluripotent stem cells.', 'The described microglial platforms can serve as tools for investigating disease biomarkers and improving the clinical translatability of the drug development process in neurodegenerative diseases.'], ['However, MNI-ICBM152 represents an average of 152 healthy young adult brains and is vastly different from brains of patients with neurodegenerative diseases.'], ['Their differences and similarities compared to human worth notice by future translational research in degenerative fundus diseases, especially age-related macular degeneration.'], ['Our work supports previous findings, suggesting that the KL-VSHET+ on an APOE epsilon4 genotype background may modulate Abeta and tau pathology, thereby lowering the intensity of neurodegeneration and incidence of cognitive decline in older controls susceptible to AD.'], ['Oxidative stress induced by 4-hydroxynonenal (4-HNE) is closely related to neurodegenerative diseases and aging.'], ['The structural and functional changes associated with T2DM show marked overlap with the effects correlating with age but appear earlier, with disease duration linked to more severe neurodegeneration.', 'T2DM gray matter atrophy occurred approximately 26% +- 14% faster than seen with normal aging; disease duration was associated with increased neurodegeneration.'], ['This article will introduce in detail the composition and source of dural immune cells; as well as the changes in the dural immune landscape under various central nervous system (CNS) diseases (such as aging and neurodegeneration, autoimmune diseases, tumor, infection, stroke and migraine).'], ["Alzheimer's disease (AD) is a common degenerative brain disorder of aging people which shares many clinical and pathological features with canine cognitive dysfunction (CCD)."], ["Dysfunctional mitochondria are a central aspect of aging and neurodegenerative diseases such as Alzheimer's disease (AD)."], ['Importance: Schizophrenia is associated with major cognitive deficits and has been conceptualized as both a neurodevelopmental and a neurodegenerative disorder.'], ["BACKGROUND: Parkinson's disease (PD) is an increasingly common neurodegenerative disease in an aging society."], ['Along with genetic factors, environmental factors, and aging also increase the risks of developing neurodegenerative disorders.'], ["Alzheimer's Disease (AD) is the most prevalent neurodegenerative disease placing a great burden on people living with it, carers and society.", 'We show that EphA1 did not cause neurodegeneration, shorten lifespan or affect memory but flies mis-expressing the wild-type or mutant receptor were hyper-aroused, had reduced sleep, a stronger circadian rhythm and increased clock neuron activity and excitability.'], ['The Mediterranean diet, including walnuts, seems to prevent age-related neurodegeneration.'], ['Most neurodegenerative disorders take decades to develop, and their early detection is challenged by confounding non-pathological ageing processes.', 'Overall, the results describe distinct disease-specific pathomechanisms, both within the brain and peripherally, for the two most common neurodegenerative disorders.'], ['Oxidative stress is a shared pathology of neurodegenerative disease and brain injuries, and is derived from perturbations to normal cell processes by aging or environmental factors such as UV exposure and air pollution.', 'Therefore, oxidative damage and disruption of the BBB is an emergent focus of neurodegenerative disease etiology and progression.', 'We first established doses of hydrogen peroxide to induce chronic damage (modeling aging and neurodegenerative disease) and acute damage (modeling the response to traumatic brain injury) by assessing barrier function via transendothelial electrical resistance in 2D iBMEC monolayers and permeability and monolayer integrity in 3D tissue-engineered iBMEC microvessels.'], ["Alzheimer's disease (AD) is one of the most common, progressive neurodegenerative disorders affecting the aged populations."], ['Plasma biomarkers of amyloid, tau, and neurodegeneration may provide a screening avenue to identify those with CMBs, but evidence is conflicting.'], ['It is not obvious how to define a neurodegenerative disorder.'], ['Aging is a major risk factor for neurodegenerative diseases and, as lifespans are increasing, these health challenges are becoming more prevalent.', 'In this review, we describe the involvement of adult neurogenesis in neurodegenerative diseases and address the molecular mechanistic aspects of neurogenesis that involve some of the key aggregation-prone proteins in the brain (i.e., tau, Abeta, alpha-synuclein, ...).', 'Lastly, we share our outlook on restoring the levels of neurogenesis to physiological levels in elderly individuals and those with neurodegeneration.', 'We suggest that modulating neurogenesis represents a potential target for interventions that could help in the fight against neurodegeneration and cognitive decline.'], ["Alzheimer's disease (AD) is one of the most severe neurodegenerative diseases observed in the elderly population."], ['Objective: To assess and compare the diagnostic value of the magnetic resonance parkinsonism index (MRPI) and other magnetic resonance imaging-based measures of cerebral atrophy to differentiate between PSP, CBD, and other neurodegenerative diseases.', 'Design, Setting, and Participants: This prospective diagnostic study included participants with 4-repeat tauopathies (4RT), PSP, CBD, other neurodegenerative diseases and available MRI who appeared in the University of California, San Francisco, Memory and Aging Center database.'], ['Context: Aging can contribute to a decrease in physical activity as a result of metabolic dysfunction and hormonal imbalance that can cause degenerative joint disease and aging-related inflammation.'], ["Recent studies using dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) with gadolinium-based contrast agents (GBCA) have demonstrated subtle blood-brain barrier (BBB) leaks in the human brain during normal aging, in individuals with age-related cognitive dysfunction, genetic risk for Alzheimer's disease (AD), mild cognitive impairment, early AD, cerebral small vessel disease (SVD), and other neurodegenerative disorders."], ['The molecule is lipophilic and can easily cross the BBB (Blood-Brain Barrier) and hence protects from neurodegenerative diseases.', 'Various in vivo and in vitro studies have demonstrated the role of quercetin and here a detailed review of quercetin as a curative agent in neurodegeneration, diabetes, cancer, and inflammation has been carried out.'], ["The ageing of the population is resulting in neurodegenerative diseases, including Alzheimer's disease (AD), which are an increasing social, economic and medical problem.", 'Our review of the literature in the PubMed database supports the hypothesis that complementary factors, such as proper diet, physical exercise and mental activity, have a positive impact on the prevention of neurodegenerative diseases.', 'Therefore, the introduction of Mediterranean and Asian diets may reduce the risk of the neurodegenerative diseases associated with dementia, whereas dairy products and meat-the main sources of L-carnitine-should be consumed in moderate amounts.'], ['Protein misfolding is a common basis of many neurodegenerative diseases including amyotrophic lateral sclerosis (ALS).', 'Here, we review aspects of DnaJC7 expression, interaction, and function to propose a loss-of-function mechanism by which pathogenic variants in DNAJC7 contribute to defects in DnaJC7-mediated chaperoning that might ultimately contribute to neurodegeneration in ALS.'], ["Parkinson's disease (PD) is an aging-related disease and the second most common neurodegenerative disease after Alzheimer's disease."], ['CONCLUSIONS: We found a significant correlation between Tau (pTau) and neurodegeneration biomarkers (tTau and hippocampus volume) with GCL degeneration and, to a lesser degree, with damage in RFNL.', 'OCT analysis constitutes a non-invasive and unexpensive biomarker that allows the detection of neurodegeneration in cognitively asymptomatic individuals.'], ["Parkinson's disease (PD) is a neurodegenerative disease caused by aging, environmental and genetic factors, and many susceptibility genes have been found to increase the risk for PD."], ['Significant alterations in lipid metabolism and valine, leucine, and isoleucine metabolism, as well as neurodegenerative diseases and sex differences in the pathogenesis of AAA and AOD were identified.'], ['We investigated combining a core AD neuropathology measure (plasma amyloid-beta [Abeta] 42/40) with five plasma markers of inflammation, cellular stress, and neurodegeneration to predict cognitive decline.'], ['Peak energy capacity of the whole person is associated with neurodegeneration.'], ['Voxelwise tau patterns, amyloid, neurodegeneration, cognition, and demographic characteristics were examined.'], ['Our results reveal that PD-associated etiological factors precipitated brain genotoxic stress and detail a useful tool for probing the pathogenic significance in aging and neurodegenerative disorders.'], ['Oxidative stress-induced degeneration and dysfunction of chondrocytes plays a key role in the pathological progression of osteoarthritis (OA), a common degenerative joint disease in the elderly.'], ['Previous studies demonstrated that aging, neurodegeneration, and the level of physical activity are associated with vascular alterations.'], ['If misrepaired, DSBs can lead to cancer, neurodegeneration, immunodeficiency and premature ageing.'], ['Objective: To investigate the combined impact of aerobic exercise and Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) diet on brain cells longevity in spite of sex hormones deficiency in obese postmenopausal women.'], ['MAIN EXPOSURE: A healthy lifestyle score was developed based on five modifiable lifestyle factors: a diet for brain health (Mediterranean-DASH Diet Intervention for Neurodegenerative Delay-MIND diet score in upper 40% of cohort distribution), late life cognitive activities (composite score in upper 40%), moderate or vigorous physical activity (>=150 min/week), no smoking, and light to moderate alcohol consumption (women 1-15 g/day; men 1-30 g/day).'], ['Neurofilament light (Nf-L), a neuronal cytoplasmic protein, is a biomarker of neurodegeneration measurable in biofluids.', "Our findings suggest that Nf-L may serve as a potential biomarker for neurodegeneration, including Parkinson's disease outcomes."], ['BACKGROUND: Development of neurodegeneration in older people has been associated with microglial cell activation triggered by systemic infection.'], ['As the size of the neuroimaging cohorts being increased to address key questions in the field of cognitive neuroscience, cognitive aging, and neurodegenerative diseases, the accuracy of the spatial normalization as an essential preprocessing step becomes extremely important.'], ['Traumatic brain injury (TBI) is associated with the development of a range of neurodegenerative pathologies, including chronic traumatic encephalopathy (CTE).'], ['CONCLUSIONS: Our cellular model may reflect the ER stress-mediated degenerative retina and serve as a pathogenesis-oriented cost-effective rescue strategy for RP patients.'], ['INTRODUCTION: The increase in chronic degenerative diseases poses many challenges to the efficacy and sustainability of healthcare systems, establishing the family and community nurse (FCN) who delivers primary care as a strategic role.'], ['Age-related diseases presenting with high frequencies include neurodegenerative, musculoskeletal, cardiovascular, metabolic diseases and cancer.'], ['Currently, aging is associated with several diseases, such as neurodegenerative diseases, cancer, and other diseases related to oxidative stress.'], ["Parkinson's disease (PD) is a common neurodegenerative disorder that is characterized by loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc)."], ['This imbalance plays an important role in brain aging and age-related neurodegenerative diseases.'], ['Neuroimaging-based brain age paradigm provides an individualized marker to differentiate aberrant brain aging patterns in neurodegenerative diseases.'], ['BACKGROUND: Alpha-synuclein (alpha-syn) exhibits pathological misfolding in many human neurodegenerative disorders.', 'We previously showed that alpha-syn is arginylated in the mouse brain and that lack of arginylation leads to neurodegeneration in mice.', 'CONCLUSION: We propose that alpha-syn arginylation constitutes a potential neuroprotective mechanism that prevents its abnormal accumulation during neurodegeneration and aging in the human brain.'], ['Longitudinal fMRI studies hold great promise for the study of neurodegenerative diseases, development and aging, but realizing their full potential depends on extracting accurate fMRI-based measures of brain function and organization in individual subjects over time.', 'This is especially true for studies of rare, heterogeneous and/or rapidly progressing neurodegenerative diseases.', 'This study also provides the first real-world example of how surface-based spatial Bayesian analysis of task fMRI can further scientific understanding of neurodegenerative disease and other phenomena.'], ['SH2B1, an intracellular adaptor protein, contributes to the signal transduction of several receptor tyrosine kinases and exerts beneficial metabolic effects for body weight regulation; however, whether SH2B1 plays a major role in pathological neurodegeneration in PD has not yet been investigated.', 'This is the first study to examine the molecular underpinnings of SH2B1 against MPTP-induced neurodegeneration through cell autonomous promotion of neuronal survival in an in vivo PD model.'], ['Altered brain growth or rates of decline are implicated in a vast range of psychiatric, developmental and neurodegenerative diseases.'], ['There is substantial interest in the potential for traumatic brain injury to result in progressive neurological deterioration.', 'Given increasing evidence that these proteins may be markers of ongoing neurodegeneration in a range of diseases, we examined their relationship to imaging changes and functional outcome in the months to years following traumatic brain injury.'], ['Importance: Sleep disturbance is common among patients with neurodegenerative diseases.', 'These findings suggest that the subcortical system is a primary mechanism associated with sleep disturbances in the early stages of neurodegenerative diseases.'], ['SIRT2, thus affects most likely multiple cellular processes, such as signaling, gene expression, aging, autophagy, and has been identified as potential drug target in relation to inflammation, neurodegenerative diseases and cancer.'], ['Here we explored the possible relations among variants in 3 genes involved in inflammation and neurodegenerative disorders (APOE: epsilon2/epsilon3/epsilon4; HFE: H63D; C9ORF72: hexanucleotide expansions >= 9 repeats), cognitive/functional impairment (MiniMental State Examination MMSE, Clock Drawing Test CDT, Short Physical Performance Battery SPPB), comorbidities and HIV-related variables in a cohort of > 50 years old PWH (n = 60) with at least 10 years efficient ART.'], ['Here, we examine the role of proteases in aging and age-related neurodegeneration.', "Specifically, we examine how certain proteases promote the progression of Alzheimer's, Huntington's, and/or Parkinson's disease whereas other proteases protect from neurodegeneration.", 'Altogether, these studies indicate the importance of proteases in aging and age-related neurodegeneration.'], ['Aging is the single largest risk factor for many debilitating conditions, including heart diseases, stroke, cancer, diabetes, and neurodegenerative disorders.'], ['Nevertheless, our algorithms offer a broad insight into the clinical heterogeneity of ALS and help to determine the actual subtypes of disease that exist within this fatal neurodegenerative syndrome.'], ["In this review we highlight key aspects of mitochondria's role in CNS' physiology and neurodegenerative disorders, focusing on AD."], ['Although preclinical studies showed that the vitamin D endocrine system plays a role in certain neural cells as well as brain structure and function, there is no evidence to support a beneficial effect of vitamin D in neurodegenerative diseases.'], ['With the aging society, musculoskeletal degenerative diseases are becoming a burden on society, and rotator cuff disease is one of these degenerative diseases.'], ['Cancer and neurodegenerative diseases are two of the leading causes of premature death in modern societies.', 'Their incidence continues to increase, and in the near future, it is believed that cancer will kill more than 20 million people per year, and neurodegenerative diseases, due to the aging of the world population, will double their prevalence.', 'However, whereas in cancer, these alterations lead to cell survival and proliferation, neurodegenerative diseases trigger cell death and apoptosis.', "Here, we review the ten most common signaling pathways altered in cancer and analyze them in the context of different neurodegenerative diseases such as Alzheimer's (AD), Parkinson's (PD), and Huntington's (HD) diseases."], ['Neurodegenerative diseases originate from neuronal loss in the central nervous system (CNS).', 'There is no clear-cut universal mechanism for identifying neurodegenerative diseases, and therefore, they pose a challenge for neurobiology scientists.', 'Prior studies have shown that miRNA levels are altered during the course of the disease, thereby suggesting that these noncoding RNAs may be the contributing factor in neurodegeneration.', 'In this review, we highlight the role of miRNAs in the pathogenesis of neurodegenerative diseases.', 'Third, we focus on the dysregulation of miRNAs and their target genes leading to several neurodegenerative diseases.', 'We list some of the innovative strategies employed to deliver miRNA into target cells and the relevance of these viral and non-viral carrier systems in RNA therapy for neurodegenerative diseases.', 'In summary, this review highlights the relevance of studying brain-enriched miRNAs, the mechanisms underlying their regulation of target gene expression, their dysregulation leading to progressive neurodegeneration, and their potential for biomarker marker and therapeutic intervention.', 'This review thereby highlights ways for the effective diagnosis and prevention of these neurodegenerative disorders in the near future.'], ["Alzheimer's disease (AD) is one of the most complicated progressive neurodegenerative brain disorders, affecting millions of people around the world."], ['It has been shown that healthy elderly skin expresses amyloidogenic proteins, including alpha-Synuclein, which are known to oligomerize and trigger inflammation and neurodegeneration.'], ["INTRODUCTION: : Alzheimer's disease (AD) and Parkinson's disease (PD) are neurodegenerative disorders causing cognitive deficits and motor difficulties in the elderly."], ['Values reported should provide useful normative ranges for how PSD volume adjusts with age, which will serve as a necessary pre-requisite for comparisons to persons with neurodegenerative disorders.'], ['METHODS: We analyzed the distribution of neurodegenerative disease associated proteins in postmortem brain samples from 11 DS cases (6 females, median age 57, range 38-66 years).'], ["Alzheimer's disease (AD) is the common neurodegenerative disease in the center never system and the typical dementia in old people."], ['Thus, a variety of research teams have been using LC-MRI to estimate LC integrity in normal aging and in patients affected by neurodegenerative disorders, where LC integrity my work as a biomarker.'], ['Under pathological conditions, human tau (htau) hyperphosphorylation promotes formation of proteotoxic intracellular amyloid aggregates that may underlie neurodegenerative diseases known as tauopathies, prompting researchers to develop treatments that inhibit htau aggregation as a promising therapeutic strategy.', 'Our findings indicated that ginsenoside Rf prevented tau aggregation and reversed abnormal tau aggregation-induced phenotypes and alleviated neurodegeneration in worms.'], ['Drug dependence on morphine is commonly accompanied by neurodegenerative disorders.'], ["Though activation on a chronic scale will certainly lead to neurodegeneration, this emerging knowledge of a potential beneficial aspect of immune activation allows us to form holistic insights into when, where, and how much immune system activity would need to be tuned to impact the Alzheimer's neurodegenerative cascade."], ['Diffusion metrics predicted amyloid status incrementally over age (AUC=0.84) with modest yet selective associations, where AWF (a marker of axonal density) correlated with speed/executive functions and neurodegeneration, whereas De, (a marker of gliosis/myelin repair) correlated with amyloid deposition and white matter hyperintensity volume.'], ['In this work, we focused on the role of BACH1/NRF2 ratio in the regulation of the anti-oxidant response, proposing their antithetical relation as a valuable target for a therapeutic strategy to test drugs able to exert neuroprotective effects, notably in aging and neurodegenerative diseases.'], ['Neurodegenerative disorders are gaining ever more importance in ageing populations of animals and people.', "Altered insulin signaling and type II diabetes have been linked to the development of Alzheimer's disease (AD) in humans and AD-like neurodegeneration in other long-lived animals."], ['It is a novel member of the sirtuin family that has been shown to have an important role in various molecular pathways in glycolysis, cancer, and neurodegenerative responses.', 'In this review, we summarized the connection between SIRT6 and glycolytic metabolism; discussed recent developments in the involvement of SIRT6 in a variety of life-threatening illnesses, including cancer, neurodegenerative diseases and cardiovascular disease; and explored possible treatment approaches for those diseases with SIRT6.'], ['Indeed, many studies show that fasting ameliorates many biochemical parameters related to cardiovascular and cancer risk, and neurodegeneration.'], ["INTRODUCTION: Parkinson's disease (PD) and Alzheimer's disease (AD) are the most common neurodegenerative diseases in the elderly."], ["Parkinson's disease is a chronic neurodegenerative disease that affects a large portion of the population, especially the elderly."], ['The DNA damage response contains overlapping signalling networks that repair DNA and hence maintain genomic integrity, and aberrant DNA damage responses are increasingly described in neurodegenerative diseases.', 'Neuronal death is thus an important process in neurodegenerative disorders.'], ['In the recent past, stroke research and treatment have become key scientific issues that need urgent solutions, with a sharp focus on stem cell transplantation, which is known to treat neurodegenerative diseases related to traumatic brain injuries, such as stroke.'], ['Adult hippocampal neurogenesis-the generation of new functional neurones in the adult brain-is impaired in aging and many neurodegenerative disorders.'], ['Design, Setting, and Participants: The Imaging-Based Coordinate System for Aging and Neurodegenerative Diseases (iSTAGING) study is an international multicenter consortium investigating brain aging in pooled and harmonized data from 13 studies with more than 35 000 participants, including a subset of individuals with major depressive disorder.'], ["Alzheimer's disease (AD) is a neurodegenerative disease associated with aging, and the number of people affected is rapidly increasing.", 'Turmeric is effective in treating neurodegenerative diseases, but there is no effective way to identify active compounds from their complicated chemical compositions.'], ['Over time Abeta pathology drives neurofibrillary tangle (NFT) pathology, dysfunction of virtually all cell types in the brain, and ultimately, overt neurodegeneration.'], ["DNAm age acceleration was associated with disease risk and/or variable disease phenotypes in several repeat associated neurodegenerative diseases (such as Huntington's disease and Amyotrophic lateral sclerosis)."], ["Parkinson's disease is a neurodegenerative disorder clinically characterized by bradykinesia, rest tremor, rigidity, and postural and gait disturbances, which are frequently observed in older people."], ['The destructive effects of free radicals may also cause harm to membranes, enzymes, and DNA, leading to several human diseases such as cancer, atherosclerosis, malaria, coronavirus disease (COVID-19), rheumatoid arthritis, and neurodegenerative illnesses.'], ["The study's second aim was to evaluate the association between physical and cognitive functions with circulating markers of neurodegeneration and cognitive impairments in elders.", 'However, both trainings may be important factors modifying the concentration of circulating proteins associated with neurodegenerative and cognitive disorders.'], ['In addition, basic and clinically oriented studies that investigate organ/tissue/cell dysfunction in various human diseases, including myopathies, cardiac/brain ischemia-reperfusion injuries, neurodegenerative diseases, cancer, and aging, require precise estimation of mitochondrial function.'], ["It represents an increasingly important public health problem and can depend on normal aging or be linked to different neurodegenerative disorders, including Alzheimer's disease (AD)."], ['Recent evidence indicates that neurodegeneration is a critical element of diabetic retinopathy (DR) pathogenesis.', 'Therefore, neurodegeneration represents an early intervention target to slow and prevent the development of microvascular alterations visible on clinical examination.', 'Clinical features of neurodegeneration are crucial in identifying patients at high risk of developing a vascular impairment and, thus, serve as outcome measures to understand the efficacy of supplementation.', 'The optimal approach for targeting neurodegeneration contemplates the use of topical compounds that possibly act on different elements of the pathogenic cascade.'], ['For patients suffering from neurodegenerative disorders, the behavior and activities of daily living are an indicator of a change in health status, and home-monitoring over a prolonged period of time by unobtrusive sensors is a promising technology to foster independent living and maintain quality of life.'], ["BACKGROUND: A complex network of aging-related homeostatic pathways that are sensitive to further deterioration in the presence of genetic, systemic, and environmental risk factors, and lifestyle, is implicated in the pathogenesis of progressive neurodegenerative diseases, such as sporadic (late-onset) Alzheimer's disease (sAD)."], ['Therefore, autophagy dysfunctions are intimately associated with many human diseases such as cancer, neurodegeneration, obesity, diabetes, infection, and aging.'], ['In mouse models of diseases displaying genome instability, type-I Interferon response is responsible for an important part of the pathological symptoms, including premature aging, short stature, and neurodegeneration.'], ['CCH activates a molecular and cellular injury cascade that leads to breakdown of the blood brain barrier (BBB) and neurodegeneration.'], ["Neurodegenerative diseases such as Alzheimer's disease (AD) are becoming more prevalent in our aging society."], ["Plasma biomarkers related to amyloid, tau, and neurodegeneration (ATN) show great promise for identifying these pathological features of Alzheimer's Disease (AD) as shown by recent clinical studies and selected autopsy studies."], ['This neurodegenerative disease disproportionately affects women.', 'Machine learning indicates sex differences in CT are most relevant early in the ADD neurodegeneration.'], ['This article will review findings regarding the interaction between HIV-1 infection and age-related comorbidities, namely atherosclerosis and neurodegenerative diseases, followed by cognitive outcomes of people with HIV in longitudinal studies.'], ["Epidemiological studies involving data from millions of patients or volunteers have associated PM with increased risk of dementia and Alzheimer's disease in the elderly and cognitive dysfunction and neurodegenerative pathology across all age groups, suggesting that PM may be a risk factor for neurodegenerative diseases.", 'Neurodegenerative diseases affect an increasing population in this aging society, putting a heavy burden on economics and family.', 'Therefore, understanding the mechanism by which PM contributes to neurodegeneration is essential to develop effective interventions.', 'Evidence in human and animal studies suggested that PM induced neurodenegerative-like pathology including neurotoxicity, neuroinflammation, oxidative stress, and damage in blood-brain barrier and neurovascular units, which may contribute to the increased risk of neurodegeneration.', "Interestingly, antagonizing oxidative stress alleviated the neurotoxicity of PM, which may underlie the essential role of oxidative stress in PM's potential effect in neurodegeneration.", 'This review summarized up-to-date epidemiological and experimental studies on the pathogenic role of PM in neurodegenerative diseases and discussed the possible underlying mechanisms.'], ['Transactive response DNA-binding protein of ~43 kDa (TDP-43), a primary pathologic substrate in tau-negative frontotemporal lobar degeneration (FTLD), is also often found in the brains of elderly individuals without FTLD and is a key player in the process of neurodegeneration in brains with and without FTLD.', 'Therefore, we explored whether neurodegeneration also varies due to the morphologic type.', 'Older FTLD-TDP showed a limbic predominant pattern of neurodegeneration.'], ['Higher DQI-I score, Mediterranean-DASH Intervention for Neurodegenerative Delay Diet (MIND) score and "vegetables-fruits" pattern score were associated with greater psychological function.'], ['Osteoarthritis (OA) is a progressive degenerative disease resulting in joint deterioration.'], ['It has a ubiquitous role in the development of numerous noncommunicable maladies including cardiovascular diseases, cancers, neurodegenerative diseases, aging and respiratory diseases.'], ["Zebrafish and medaka have been used extensively in the field of neurology, especially to unveil the mechanisms of neurodegenerative diseases such as Parkinson's and Alzheimer's disease, and recently, these fishes have also been utilized to understand neurodevelopmental disorders such as autism spectrum disorder."], ["Iron accumulates in the ageing brain and in brains with neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), and Down syndrome (DS) dementia.", 'The identification of several proteins that are involved in iron homeostasis, transport, and regulation suggests avenues to explore their function in neurodegenerative diseases.', 'Membrane damage and subsequent impairment of ferroportin and hepcidin causes oxidative stress that contributes to neurodegeneration seen in DS, AD, and in PD subjects.', 'We further propose that a lack of ferritin contributes to neurodegeneration as a consequence of failure to export toxic metals from the cortex in AD/DS and from the substantia nigra and caudate/putamen in PD brain.'], ['Here, we provide an overview on recent findings describing the epigenetic changes that arise during aging and in related maladies such as neurodegeneration and cancer.'], ['P-tau231 was sensitive to the earliest changes of Abeta in the medial orbitofrontal, precuneus and posterior cingulate before global Abeta PET positivity was reached INTERPRETATION: We demonstrate that CSF p-tau231 increases early in development of AD pathology and is a principal candidate for detecting incipient Abeta pathology for therapeutic trial application FUNDING: Canadian Institutes of Health Research (CIHR), Canadian Consortium of Neurodegeneration and Aging, Weston Brain Institute, Brain Canada Foundation, the Fonds de Recherche du Quebec.'], ['The mitochondrial (mt) DNA "common deletion" mutation (mtCDM) is a 4977-bp deletion associated with aging and neurodegenerative diseases.', 'We examined how mtDNA and mtCDM correlate with markers of neurodegeneration and inflammation in people with and without HIV (PWH and PWOH).', 'Our findings suggest mtDNA changes in oral tissues may reflect CNS processes, allowing the use of inexpensive and easily accessible buccal biospecimens as a screening tool for CSF inflammation and neurodegeneration.', 'Confirmatory and mechanistic studies on mt genome alterations by HIV and ART may identify interventions to prevent or treat neurodegenerative complications.'], ["Classified as the second most common neurodegenerative disorder associated with aging after Alzheimer's disease, Parkinson's disease (PD) is the most common movement disorder."], ['BACKGROUND: Air pollution may cause inflammatory and oxidative stress damage to the brain, leading to neurodegenerative disease.'], ['The aging process predisposes numerous homeostatic disorders, metabolic disorders, cardiovascular diseases, neurodegenerative diseases, and cancer.'], ['METHODS: Participants included 75 individuals diagnosed with PD from the Arizona Study of Aging and Neurodegenerative Disorders.'], ['HtrA1 is a serine protease involved in a variety of biological functions regulating many signaling pathways degrading specific components and playing key roles in many human diseases such as neurodegenerative disorders, pregnancy complications and cancer.'], ['ADVANCES IN KNOWLEDGE: Brain iron deposits may be normal, owing to aging, or be pathological, such as neurodegeneration.'], ["BACKGROUND: Astrocytes and microglia react to Abeta plaques, neurofibrillary tangles, and neurodegeneration in the Alzheimer's disease (AD) brain."], ["Alzheimer's disease (AD) has been an intractable neurodegenerative disease among the elderly in the worldwide."], ['Importantly, neurodegeneration appears to occur within these networks in a dissociable manner marked by their covariance patterns.'], ['An argument is made for why medical professionals in the perioperative setting need fundamental training in cognitive-behavioral principles, an understanding of neurodegenerative diseases of aging, and an appreciation of the immediate and long-term medical risks for such patients undergoing anesthesia.', "The author's goal is to encourage readers to consider perioperative cognitive medicine as a new frontier for generating evidence-based care approaches for at-risk older adults with neurodegenerative disorders who require procedures with anesthesia."], ["Alzheimer's disease (AD) is the most common neurodegenerative disease, which results in dementia typically in the elderly.", 'The purpose of this study is not only to determine the potential treatment of AD, but also other related neurodegenerative diseases.'], ["In the ageing brain, neurogenic capability progressively declines while in parallel increases the risk for developing Alzheimer's disease (AD), the main neurodegenerative disorder associated with memory loss."], ['Intervertebral disc degeneration is a very common type of degenerative disease causing severe socioeconomic impact, as well as a major cause of discogenic low back pain and herniated discs, placing a heavy burden on patients and the clinicians who treat them.'], ['Lysosomal peptidases have also been identified as hallmarks of aging and neurodegeneration, playing roles in oxidative stress, mitochondrial dysfunction, abnormal intercellular communication, dysregulated trafficking, and the deposition of protein aggregates in neuronal cells.', 'The aim of this review is to highlight the role of lysosomal peptidases in particular pathological processes of cancer and neurodegeneration and to address the potential of lysosomal peptidases in diagnosing and treating patients.'], ['Recent studies have emphasized the changes in large-scale brain networks related to healthy aging, with the ultimate purpose to aid in differentiating normal neurocognitive aging from neurodegenerative disorders that also arise with age.'], ['FUNDING: National Institute on Aging, Doris Duke Charitable Foundation, German Center for Neurodegenerative Diseases, Japanese Agency for Medical Research and Development.'], ['Rarely do we appreciate the remarkable coordination in reach-to-grasp, until control becomes impaired by neurological injuries such as stroke, neurodegenerative diseases, or even aging.'], ["The observed death of pyramidal neurons in the CA1 region of the hippocampus and its atrophy are considered to be typical changes for post-ischemic brain neurodegeneration and for Alzheimer's disease.", 'The available data suggest that curcumin may be a new therapeutic substance in both regenerative medicine and the treatment of neurodegenerative disorders such as post-ischemic neurodegeneration.'], ['A determination of mitochondria failure in increasing oxidative stress, as well as its implications in neurodegenerative illnesses and apoptosis, is a significant developmental process of focus in this review.', 'In conclusion, the study of secondary components and the use of mitochondrial features in the analysis of various neurodevelopmental diseases has enabled the development of a new class of mitochondrial-targeted pharmaceuticals capable of alleviating neurodegenerative disease states and enabling longevity and healthy ageing for the vast majority of people.'], ['8-oxo-guanine (8OG) is a common base lesion, generated by reactive oxygen species, which has been associated with human diseases such as cancer, aging-related neurodegenerative disorders and atherosclerosis.'], ['CONCLUSION: The association between delirium and cognitive impairment and the possible role of delirium as an early marker of neurodegenerative diseases need to be future investigated.'], ['Senescence and the SASP are major factors in aging, cancer, and degenerative diseases, and interfere with the expansion of adult cells in vitro, yet little is known about how to counteract their induction and deleterious effects.', 'Our work reveals how WNT signals can antagonize senescence and has relevance not only for expansion of adult cells but can also provide new insights into senescence-associated inflammatory and degenerative diseases.'], ['Progressive accumulation of damage is suspected to contribute to neurodegenerative diseases and aging, but the molecular identity of the damage remains largely unknown.'], ["There is a growing number of association studies exploring the gut microbiota's possible role in memory, learning, anxiety, stress, neurodevelopmental and neurodegenerative disorders."], ["This hormetic framework is applied to the assessment of olive polyphenols with respect to their capacity to slow the onset and reduce the magnitude of a wide range of age-related disorders and neurodegenerative diseases, including Alzheimer's Disease and Parkinson's Disease."], ["As the second most common progressive neurodegenerative disorder with increased prevalence in the aging population, Parkinson's disease (PD) affects more than 10 million individuals worldwide with approximately 60,000 new cases occurring each year only in the US."], ['BACKGROUND: Management of degenerative disease of the spine has evolved to favor minimally invasive techniques, including nonrobotic-assisted and robotic-assisted minimally invasive transforaminal lumbar interbody fusion (MIS-TLIF).'], ['Apparently based on the fact that the nervous system and skin share a common ectodermal origin, certain genes and molecular pathways associated with the pathomechanism of neurodegenerative diseases modify their expression with progressing skin aging.'], ['Some clinicians consider the condition as a separate entity among neurodegenerative disorders whereas others find the term unhelpful due to its uncertain prognosis.'], ['METHODS: This 18-month clinical trial longitudinally measured brain structure volumes by magnetic-resonance-imaging using hippocampal-occupancy (HOC) and lateral-ventricle-volume (LVV) expansion scores as neurodegeneration markers.'], ['BACKGROUND: Knee osteoarthritis (KOA) is a chronic degenerative disease characterized by pain, morning stiffness and swelling in the knee joints.'], ['Phenolic compounds can inhibit enzymes associated with the development of human diseases and have been used to treat various common human ailments, including hypertension, metabolic problems, incendiary infections, and neurodegenerative diseases.'], ["Alzheimer's disease (AD) is the most common form of neurodegenerative disorders affecting mostly the elderly."], ['Neurodegenerative diseases are characterized by a progressive loss of neurons of the central nervous system (CNS) and serve as a major cause of morbidity, mortality and functional dependence especially among the elderly.'], ["BACKGROUND: Declining proteostasis with aging contributes to increased susceptibility to neurodegenerative diseases, including Alzheimer's disease (AD)."], ['Subcortical functioning is crucial for behavior, and disrupted function is observed in common neurodegenerative diseases.', 'The results further our understanding of subcortical morphometry and neuroimaging properties, and of normal aging processes which ultimately can improve our understanding of neurodegeneration.'], ['Still, only a few studies have addressed the prevalence and clinical characteristics of pain in neurodegenerative disorders with atypical parkinsonism.', "The existing evidence, although scarce, suggests that, similarly as in Parkinson's disease, individuals with neurodegenerative diseases with atypical parkinsonism might be predisposed to the development of persistent pain.", 'Today, as the global population is aging and we face an epidemic of neurodegenerative disorders, under-treated pain is taking a great toll on an ever-rising number of people.', 'Here, we provide an up-to-date review of the current knowledge on the prevalence of pain, its clinical features, and findings from experimental studies that might signpost altered pain processing in the most prevalent neurodegenerative disorders with atypical parkinsonism: multiple system atrophy, progressive supranuclear palsy, corticobasal syndrome, frontotemporal dementia, and dementia with Lewy bodies.', 'Large-scale, high-quality clinical trials, coupled with pre-clinical research, are urgently needed to reveal the exact pathophysiological mechanisms underpinning heightened pain and pave the path for mechanistically-driven analgesic interventions to be developed, ultimately leading to an improvement in the quality of life of individuals with neurodegenerative disorders.'], ['BACKGROUND: Neurofilament light chain (NFL) level has been suggested as a blood-based biomarker for neurodegeneration in dementia.'], ['Potentially, these models could be applied during routine clinical examinations to detect deviations from healthy ageing, including early-stage neurodegeneration.'], ['It is reported by several scientists that, besides the systemic alteration, LPS also induces neurodegeneration by promoting neuroinflammation upon binding with the stimulation of Toll-like receptor-4 (TLR4) receptors present on glial cells.'], ['Evidences suggest a possible association between neurodegeneration, neuroaxonal alterations and BD.'], ['Various cellular and molecular events have been shown to play a role in the progress of neurodegenerative diseases.'], ['Tauopathy is a term that has been used to represent a pathological condition in which hyperphosphorylated tau protein aggregates in neurons and glia which results in neurodegeneration, synapse loss and dysfunction and cognitive impairments.'], ["BACKGROUND: Alzheimer's disease (AD) is a neurodegenerative impairment mainly recognized by memory loss and cognitive deficits.", 'RESULTS: With several ongoing clinical trials, stem cells and their derivatives (e.g., exosomes) are an emerging and encouraging field in diagnosing and treating neurodegenerative diseases.'], ["Alzheimer's is a neurodegenerative disease with high morbidity and mortality in the elderly, so, detection of its biomarker for definite diagnosis of Alzheimer's in the early stage of disease is a challenge."], ['Declines in physiological functions are the predominant risk factors for age-related diseases, such as cancers and neurodegenerative diseases.'], ["Among them, tauopathies, such as Alzheimer's Disease (AD) and Frontotemporal Lobar degeneration (FTLD-tau), are neurodegenerative disorders pathologically defined by the presence of hyperphosphorylated tau-positive intracellular inclusions known as neurofibrillary tangles (NFTs)."], ['Notably, Thy1-ApoE4/C/EBPbeta mice develop amyloid deposits, Tau aggregates and neurodegeneration in an age-dependent manner, leading to synaptic dysfunction and cognitive disorders.'], ['The advent of the cellular reprogramming of somatic cells, i.e., dermal fibroblasts, to obtain directly induced neurons (iNs) and induced pluripotent stem cell- (iPSC-) derived neurons is technical sound advances that could open the avenues to understand better the contribution of aging toward neurodegeneration.', 'We will address the evidence showing that iNs retain age-related features in contrast to iPSC-derived neurons that lose the aging signatures during the reprogramming to pluripotency, rendering iNs a powerful strategy to deepen our knowledge of the processes driving normal cellular function decline and neurodegeneration in a human adult model.'], ["Alzheimer's disease (AD) is a degenerative brain disease that is the most common cause of dementia."], ["Various microRNAs were recently reported to regulate SIRT2 expression via its 3'-untranslated region (UTR), and single nucleotide polymorphisms in the miRNA-binding sites of SIRT2 3'-UTR were identified in patients with neurodegenerative diseases."], ['Understanding the role of Pin1 in vascular homeostasis is crucial in terms of finding a new possible therapeutic player and target in vascular pathologies, including those affecting the elderly (such as small and large vessel diseases and vascular dementia) or those promoting the full expression of neurodegenerative dementing diseases.'], ["Our previous findings of a higher survival of dopaminergic neurons in the substantia nigra co-expressing Nogo-A in an animal model of Parkinson's disease suggested that Nogo-A may be associated with dopaminergic neurons resilience against Parkinson's disease neurodegeneration."], ['OBJECTIVES: We examined whether previously reported association between PM2.5 exposure and lower white matter volume (WMV) differed between women whose usual diet during the last 3 months before baseline was more or less consistent with a Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND)-like diet, a dietary pattern that may slow neurodegenerative changes.'], ['Global public health efforts to increase human lifespan have increasingly focused on lowering the risk of aging-related diseases, such as diabetes, neurodegenerative diseases, cardiovascular disease, and cancers.'], ["Alzheimer's disease (AD) is the leading type of dementia in aging people and is a progressive condition that causes neurodegeneration, resulting in confusion, memory loss, and deterioration of mental functions."], ['Among these, neurodegenerative diseases will be among the most devastating in terms of their emotional and economic impact on patients, their families, and associated subsidized health costs.', 'Neurodegeneration is accompanied by elevated oxidative damage and inflammation.'], ['The method proposed has an excellent prospect, bringing greater convenience to clinicians in making a better solid decision in clinical diagnosis of neuro-degenerative diseases.'], ['Exercise improves multiple indices of physical performance and stimulates pronounced health benefits reducing a range of pathologies including metabolic, cardiovascular, and neurodegenerative disorders.', 'In this review, we discuss shared benefits and molecular pathways driving the protective effects of endurance exercise on various neurodegenerative diseases in animal models and in humans.'], ["Circadian rhythm dysfunction and sleep disorders have been associated with aging and neurodegenerative diseases including mild cognitive impairment (MCI) and Alzheimer's disease (AD)."], ['This oxidative damage is often associated with cancer, aging, and neurodegenerative disorders.'], ['OBJECTIVES: Degenerative diseases are associated with lower healthy life expectancy and higher mortality.'], ['The objective of this study was to investigate whether effects of Abeta pathology on cognition were mediated by AD pathologies, including tau-related pathology (p-tau), neurodegeneration (t-tau, MRI measurements), axonal injury (NFL), synaptic dysfunction (neurogranin), and neuroinflammation (sTREM2, YKL-40).', 'RESULTS: Tau-related pathology, neurodegeneration, neuroinflammation are correlated with the concentration of Abeta, even in CN participants.', 'In mild cognitive impairment, tau-related pathology (26.15% of total effect) and neurodegeneration (14.8% to 47.0% of total effect) mediate the impact of Abeta on cognition.', 'CONCLUSIONS: In conclusion, early Abeta accumulation has an independent effect on cognitive decline in CN and a tau, neurodegeneration-dependent effect in the subsequent cognitive decline in MCI patients.'], ["BACKGROUND: Alzheimer's disease (AD) is a chronic neurodegenerative disease which has been characterized by progressive development of long onset early disease with complicated etiology, and may cause memory loss, cognitive impairment, and behavioral changes."], ['BACKGROUND: Total tau protein (T-Tau) and neurofilament light chain (NfL) have emerged as candidate plasma biomarkers of neurodegeneration, but studies have not compared how these biomarkers cross-sectionally or longitudinally associate with cognitive and neuroimaging measures.'], ['Background: Literature shows that olfactory impairment (OI) is associated not only with neurodegenerative diseases (NDDs), but also with increased mortality.'], ["BACKGROUND: Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by cognitive decline and memory impairment."], ['Astrocytes undergo senescence in vitro and in age-associated neurodegenerative diseases, but little is known about whether this process also occurs in physiological aging, as well as its functional implication.'], ['This special issue is an important milestone in the evidence supporting MN as a reliable genomic biomarker of developmental and degenerative disease risk.'], ["Alzheimer's disease (AD) is the most prevalent neurodegenerative disorder and the most common form of dementia in the elderly."], ['Spatiotemporal dysregulation of these pathways under oxidative distress conditions is implicated in aging and age-related disorders such as neurodegenerative and cardiovascular diseases and diabetes.'], ["Disrupted iron homeostasis is associated with several neurodegenerative diseases, including Alzheimer's disease (AD), and may be partially modulated by genetic risk factors."], ['SUMMARY: Although healthy diets such as the Mediterranean diet promote brain health throughout life, specific diets, such as the Mediterranean-Dietary Approaches to Stop Hypertension Intervention for Neurodegenerative Delay diet, or specific nutrients (LC n-3 polyunsaturated fatty acids, carotenoids, vitamin D, B vitamins, polyphenols) alone or in combination, may prevent cognitive aging.', 'Diet management approaches to rescue brain energetics defects such as the Modified Mediterranean-ketogenic diet may be promising to prevent neurodegenerative diseases.'], ["Alzheimer's disease (AD) is an irreversible neurodegenerative disease that affects many older people adversely."], ["Parkinson's disease (PD) is a common age-associated neurodegenerative disorder and is frequently accompanied by neuroinflammation."], ['The role of increased brain inflammation in the development of neurodegenerative diseases is unclear.', 'We report that healthy aging and age-related neurodegenerative diseases have different cortical inflammatory signatures that are characterized by increased levels of anti-inflammatory cytokines and call into question the view that increased inflammation underlies the development of age-related neurodegenerative diseases.'], ["Alzheimer's disease (AD) is the most common progressive neurodegenerative disease.", 'The AD brain is marked by severe neurodegeneration, such as the loss of synapses and neurons, atrophy and depletion of neurotransmitter systems, especially in the hip- pocampus and cerebral cortex.'], ['BACKGROUND: Neurodegenerative disorders are a group of age-associated diseases characterized by progressive degeneration of the structure and function of the CNS.', 'Recent studies from our laboratory and others have shown that the BL actively regulates BBB integrity and meningeal lymphatic/glymphatic function in both physiological and pathological conditions, suggesting that it may play an important role in the pathogenesis and/or progression of neurodegenerative disorders.', "In this review, we focus on changes of the BL and its major components during aging and in neurodegenerative disorders, including Alzheimer's disease (AD), Parkinson's disease (PD), and amyotrophic lateral sclerosis (ALS).", 'CONCLUSIONS: Understanding BL changes and the functional significance of these changes in neurodegenerative disorders will fill the gap of knowledge in the field.', 'Our goal is to provide a clear and concise review of the complex relationship between the BL and neurodegenerative disorders to stimulate new hypotheses and further research in this field.'], ["BACKGROUND: Parkinson's disease (PD) is a common neurodegenerative disease affecting the elderly, but there is no blood test for PD diagnosis in the clinic currently."], ['In general, prevention of degenerative diseases of aging requires expertise in metabolism, nutrition, biochemistry and regulatory functions.'], ["Early diagnosis of neurodegeneration-oriented diseases that develop with the aging world is essential for improving the patient's living conditions as well as the treatment of the disease.", "Alzheimer's and Parkinson's diseases are prominent examples of neurodegeneration characterized by dementia leading to the death of nerve cells.", 'Detection of biomarkers, which are distinctive molecules in biological fluids, involved in neurodegeneration processes, has the potential to allow early diagnosis of neurodegenerative diseases.', 'Studies on biosensors, whose main responsibility is to detect the target analyte with high specificity, has gained momentum in recent years with the aim of high detection of potential biomarkers of neurodegeneration process.', "This study aims to provide an overview of neuro-biosensors developed on the basis of biomarkers identified in biological fluids for the diagnosis of neurodegenerative diseases such as Alzheimer's disease (AD), and Parkinson's disease (PD), and to provide an overview of the urgent needs in this field, emphasizing the importance of early diagnosis in the general lines of the neurodegeneration pathway.", 'In this review, biosensor systems developed for the detection of biomarkers of neurodegenerative diseases, especially in the last 5 years, are discussed.'], ['While recent studies have linked excessive brain iron to cognitive function in the context of neurodegenerative disease, little is known regarding the role of brain iron accumulation in cognitive aging in healthy adults.', 'These findings suggest that iron may have a mediating role in cognitive decline and may be an early biomarker of neurodegenerative disease.'], ['Autophagy is a critical protective pathway in neurons and ageing is the primary risk factor for common neurodegenerative diseases.'], ['The expression of Cav-1 in hippocampal neurons and synapses is related to neurodegeneration, cognitive decline, and aging.', 'This review will summarize the role of cav-1 in the development of cancer, neurodegeneration, glaucoma, cardiovascular diseases, and infectious diseases.'], ['In the last few years, however, the research on polyphenols implications in a healthy aging and especially in neurodegeneration and cognition improvement has increased dramatically.'], ['Most chronic diseases like cancer, cardiovascular ailments, neurodegenerative disorders, and autoimmune diseases are caused due to the abnormal functioning of multiple signaling pathways that give rise to critical anomalies in the body.'], ["On the other hand, VDD has frequently been associated with dementia of aging and neurodegenerative diseases (e.g., Alzheimer's, Parkinson's disease)."], ["Although there is a strict regulation mechanism for iron homeostasis in the human body and brain, it is usually inevitably disturbed by genetic and environmental factors, or disordered with aging, which leads to iron metabolism diseases, including many neurodegenerative diseases such as Alzheimer's disease (AD).", 'AD is one of the most common degenerative diseases of the central nervous system (CNS) threatening human health.'], ["Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the most common cause of dementia in aging populations."], ["Autism spectrum disorder (ASD) and Alzheimer's disease (AD) are neurodevelopmental and neurodegenerative disorders affecting two opposite ends of life span, i.e., childhood and old age."], ["INTRODUCTION: Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the most common cause of dementia among the elderly population.", 'NTFs are small proteins with therapeutic potential for human neurodegenerative diseases.'], ["Alzheimer's disease (AD) is a devastating neurodegenerative disorder affecting the aging population."], ['Using RNA sequencing data from 231 temporal cortex and 224 cerebellum samples of patients with AD and progressive supranuclear palsy (PSP), a tauopathy, we identify a striking correlation in the directionality and magnitude of gene expression changes between these two neurodegenerative proteinopathies.', 'AD and other neurodegenerative diseases are likely characterized by common disease or compensatory pathways with widespread perturbations in the whole brain.', 'These findings can be leveraged to develop multifaceted therapies and biomarkers that address these common, complex and ubiquitous molecular alterations in neurodegenerative diseases.'], ['The brain microvasculature is altered in normal aging and in the presence of disease processes, such as neurodegeneration or ischemia, but there are few methods for studying living tissues.', 'We now report that viable microvessels (MV) are readily isolated from brain tissue of subjects enrolled in studies of neurodegenerative diseases who undergo rapid autopsy (performed with <12 h postmortem interval - PMI).', 'Viable human MV allow for temporal and spatial analysis of relevant cellular and ECM components that have implications for microvascular function in neurodegenerative diseases, vascular brain injury, and neurotrauma.'], ['Physical activity may promote AD-related synaptic and cognitive resilience through reduction of pro-inflammatory microglial states.SIGNIFICANCE STATEMENT Physical activity relates to better cognitive aging and reduced risk of neurodegenerative disease, yet the cellular and molecular pathways linking behavior-to-brain in humans are unknown.'], ['These indices are considered predictors of morbidity and mortality as they are frequently altered in patients with chronic degenerative diseases, especially in those with cardiovascular and metabolic diseases.'], ['The precise means through which the neuroanatomical structures and cellular processes that mediate CE may be influenced by age-related neurodegeneration are also almost entirely unknown.'], ['Autophagy, the pathways that degrade cytoplasmic constituents in lysosomes, contribute to most biological processes from aging and neurodegeneration to pathogen restriction and immunity.'], ['Virtually all age-associated neurodegenerative disorders associated with aggregation of neurotoxic proteins are linked to defects in the cellular proteostasis network, including insufficient lysosomal hydrolysis.'], ["Alzheimer's disease (AD) is one of the most prevalent neurodegenerative diseases reported in the aging population across the globe."], ['OBJECTIVE: BRIP1 functions were reasonably well studied in DNA repair; however, there is limited data on its role and regulation during aging and neurodegenerative diseases.'], ['We delivered an online autobiographical writing task to older adult Australians from ISLAND (Island Study Linking Ageing and Neurodegenerative Disease).'], ['The repressor element-1 silencing transcription factor (REST) is a master regulator in neural cells and is believed to be upregulated with senescent stimuli, whereupon it counters hyperexcitability, insulin/insulin-like signaling pathway activity, oxidative stress, and neurodegeneration.', 'This review examines the putative mechanisms that distort the E/I balance with aging and neurodegeneration, and the putative roles of REST in maintaining neuronal homeostasis.'], ['It is becoming increasingly recognized that patients with a variety of neurodegenerative diseases exhibit disordered sleep/wake patterns.', "Here we highlight research describing a potentially reciprocal interaction between impaired sleep and circadian patterns and the accumulation of pathological signs and features in Alzheimer's disease, the most prevalent neurodegenerative disease in the elderly."], ["Parkinson's disease (PD) is the second most common neurodegenerative disease in the elderly population.", 'Similarly to other neurodegenerative diseases, the early diagnosis of PD is quite difficult.'], ["Parkinson's disease (PD) is a neurodegenerative disorder that affects over 10 million aging people worldwide."], ['In addition, we explore the current knowledge on the roles of exosomal miRNAs, lncRNAs, and circRNAs in human health and diseases, including cancers, metabolic diseases, neurodegenerative diseases, cardiovascular diseases, autoimmune diseases, and infectious diseases, to determine their potential implication in biomarker identification and therapeutic exploration.'], ['Although genetic mutations are known in rare familial form, exact cause of neurodegeneration in sporadic AD is still unknown.'], ['Three patterns of multimorbidity were identified: a musculoskeletal pattern, cardiometabolic pattern, and degenerative disease pattern.', 'Among these, the cardiometabolic (adjusted odds ratio (AOR) 1.223; 95% confidence interval (CI) 1.102, 1.357) and degenerative disease (AOR 1.185; 95% CI 1.071, 1.311) patterns were associated with a higher risk of depressive symptoms.'], ["BACKGROUND: Mitochondrial dysfunction is a feature of neurodegenerative diseases, including Alzheimer's disease (AD).", 'Changes in the mitochondrial DNA copy number (mtDNAcn) and increased mitochondrial DNA mutation burden have both been associated with neurodegenerative diseases and cognitive decline.', 'While we found low mtDNAcn in brain regions affected by pathologies, the absence of associations with mtDNA heteroplasmy burden indicates that mtDNA point mutations and small indels are unlikely to be involved in the pathogenesis of late-onset neurodegenerative diseases.'], ['The locus coeruleus is the main noradrenergic nucleus of the brain and is often affected in neurodegenerative diseases.', 'In line with recent post-mortem studies, our in vivo study confirms that locus coeruleus magnetic resonance features are not statistically significantly affected by age between 60 and 80 years, the age range usually evaluated in studies on neurodegenerative diseases.'], ['Short telomeres confer risk of degenerative diseases.'], ['Older people with HIV (PWH) experience increased risk of age-related neurodegenerative disorders and cognitive decline, such as amnestic mild cognitive impairment (aMCI).'], ['Osteoarthritis (OA) is a degenerative joint disease characterized by progressive degeneration of articular cartilage.'], ['In this work, we present a deep learning framework, namely 4D-Degenerative Adversarial NeuroImage Net (4D-DANI-Net), to generate high-resolution, longitudinal MRI scans that mimic subject-specific neurodegeneration in ageing and dementia.'], ["Alzheimer's disease (AD), acknowledged as the most common progressive neurodegenerative disorder, is the leading cause of dementia in the elderly."], ['A small percentage of individuals with pathological hallmarks of neurodegenerative disease are able to maintain normal cognition.', 'Last, to determine the causal impact of MEF2 on cognition in the context of neurodegeneration, we overexpressed Mef2a/c in the PS19 mouse model of tauopathy and found that this was sufficient to improve cognitive flexibility and reduce hyperexcitability.', 'Overall, our findings reveal a previously unappreciated role for MEF2 TFs in promoting CgR, highlighting their potential as biomarkers or therapeutic targets for neurodegeneration and healthy aging.'], ['Finally, major strides in biomarker-based diagnosis of AD and recent advances in targeted therapeutic approaches may have shifted the perspective but also highlight the continuous importance of postmortem analysis of the brain in neurodegenerative diseases.'], ['The attenuation of this association was greater when controlling for indices of cerebrovascular disease pathologies than when controlling for neurodegenerative pathologies (cerebrovascular disease: estimate, 0.019; SE, 0.008; P = .02; neurodegenerative: estimate, 0.022; SE, 0.008; P = .003), but both remained significant.'], ['BACKGROUND: Plasma neurofilament light, a novel biomarker for age-related neurodegenerative disease, may be linked to cardiometabolic risk factors, including body mass index (BMI), the allostatic load total score (ALtotal) and related continuous components (ALcomp).'], ['RECENT FINDINGS: Supraphysiological doses of androgens have been shown to contribute to neurodegeneration, decreased brain-derived neurotrophic factor, increased inflammation and decreased neuronal density in animal studies, which may correspond to changes in mood, cognition and aggression.'], ["Alzheimer's disease (AD) is a chronic neurodegenerative disease characterised by cognitive impairment, behavioural alteration, and functional decline."], ["Alzheimer's disease, the most common form of dementia in the elderly, is a kind of neurodegenerative disease.", 'M6A is related to nervous system development and neurodegenerative diseases.'], ['This study assessed if LV mass index related to cerebrospinal fluid (CSF) biomarkers of microglial activation (sTREM2 [soluble triggering receptor expressed on myeloid cells 2]), axonal injury (NFL [neurofilament light]), neurodegeneration (total-tau), and amyloid-beta, and whether these biomarkers partially accounted for associations between increased LV mass index and white matter damage.'], ['Not only does p53 loss or mutation cause cancer, but hyperactive p53 also drives various pathologies, including developmental phenotypes, premature aging, neurodegeneration, and side effects of cancer therapies.'], ['HDAC3 is required for kidney development and its aberrations actively participate in many pathological processes, such as cancer, cardiovascular diseases, diabetes, and neurodegenerative disorders, and contribute significantly to the pathogenesis of kidney diseases.'], ['Inflammation mediated by microglial cells plays an important role in progression of AD and other neurodegenerative diseases.'], ['Traumatic brain injury (TBI) may increase susceptibility to neurodegenerative diseases later in life.', 'One neurobiological parallel between chronic TBI and neurodegeneration may be accelerated aging and the nature of atrophy across subcortical gray matter structures.', 'These data may support an accelerated aging hypothesis in chronic moderate-severe TBI that coincides with a similar neuropathological profile found in neurodegenerative diseases.'], ["Alzheimer's disease (AD) is the most prevalent neurodegenerative disease in ageing, affecting around 46 million people worldwide but few treatments are currently available."], ['Both conditions are highly prevalent in patients with chronic kidney disease and other degenerative disorders, such as cardiovascular disease.'], ['Neurodegenerative diseases (NDs) are increasingly positioned as leading causes of global deaths.', 'The accelerated aging of the population and its strong relationship with neurodegeneration forecast these pathologies as a huge global health problem in the upcoming years.', 'A major molecular hallmark of most NDs is the accumulation of insoluble and toxic protein aggregates, known as amyloids, in extracellular or intracellular deposits.'], ['Though a direct correlation has not been established, research connecting age-related hearing loss (ARHL)-the number one communication disorder and one of the most prevalent neurodegenerative diseases of our aged population-and inflammaging has gained interest.'], ['However, at the same time, aging comes with complications that impact the development of autoimmunity, neurodegenerative diseases and cancer.'], ['Brain aging hallmarks, which include glial cell activation and inflammation, increased oxidative stress, mitochondrial dysfunction, and cellular senescence, increase the vulnerability of humans to various neurodegenerative diseases.'], ['These complications suggest that neural activity in the central nervous system may be altered in those patients, leading to unexpected conditions, such as neurodegeneration in elderly patients.'], ['The main trend of current research in neurodegenerative diseases (NDDs) is directed towards the discovery of novel biomarkers for disease diagnostics and progression.', 'The pathological features of NDDs suggest that diagnostic markers can be found in peripheral fluids and cells.', "Herein, we investigated the thermodynamic behavior of the peripheral red blood cells (RBCs) derived from patients diagnosed with three common NDDs-Parkinson's disease (PD), Alzheimer's disease (AD), and amyotrophic lateral sclerosis (ALS) and compared it with that of healthy individuals, evaluating both fresh and aged RBCs.", 'We established that NDDs can be differentiated from the normal healthy state on the basis of the variation in the thermodynamic parameters of the unfolding of major RBCs proteins-the cytoplasmic hemoglobin (Hb) and the membrane Band 3 (B3) protein.', 'A common feature of NDDs is the higher thermal stability of both Hb and B3 proteins along the RBCs aging, while the calorimetric enthalpy can distinguish PD from ALS and AD.', "Our data provide insights into the RBCs thermodynamic behavior in two complex and tightly related phenomena-neurodegenerative pathologies and aging, and it suggests that the determined thermodynamic parameters are fingerprints of the altered conformation of Hb and B3 protein and modified RBCs' aging in the studied NDDs."], ["Alzheimer's Disease (AD) is a neurodegenerative disease that affects cognition and is the most common cause of dementia in the elderly."], ['Since Hop is not essential in all eukaryotic cells and organisms, tuning Hop levels or activity might be beneficial for the treatment of cancer and neurodegeneration.'], ["Alzheimer's disease (AD), which mainly occurs in the elderly, is a neurodegenerative disease with a hidden onset, which leads to progressive cognitive and behavioral changes."], ['A growing body of evidence suggests that transposable element dysregulation accompanies brain aging and neurodegenerative disorders, and that transposable element activation is neurotoxic.'], ['Compromised functions in these processes are known hallmarks of both human aging and AD, the ramifications of which are suggested to underpin cognitive declines in aging and neurodegenerative disease.'], ['Diets rich in DHA are inversely proportional to cognitive decline and incidence of neurodegenerative disorders.'], ["Parkinson's disease (PD) is a chronic, neurodegenerative motor disease exhibiting familial and sporadic forms."], ['A cross-sectional paper survey was conducted during the first German lockdown among patients with a diagnosed psychiatric disorder (>= 60 years) or a diagnosed neurodegenerative disease (regardless of their age) from the department for neurodegenerative diseases and geriatric psychiatry at the University of Bonn.'], ['Age-related hearing loss, or presbyacusis, is a prominent chronic degenerative disorder that affects many older people.', 'The progression of age-related neurodegenerative diseases is associated with an altered microenvironment that reflects chronic inflammatory signaling.', 'Although several studies deciphered the molecular mechanisms that regulate microglia/macrophage dysfunction in multiple neurodegenerative diseases, limited studies have assessed the mechanisms underlying macrophage dysfunction in aged cochleae.'], ['OBJECTIVES: We aimed to investigate associations of the Mediterranean-Dietary Approaches to Stop Hypertension (DASH) Intervention for Neurodegenerative Delay (MIND) diet with physical function and grip strength.'], ["Parkinson's disease (PD) is a progressive, age-associated neurodegenerative disorder that affects an estimated 10 million people worldwide.", 'Recently, microRNAs (miRNAs) have emerged as novel therapeutic targets in various diseases, such as cancer and neurodegenerative diseases.', 'MiRNAs have been shown to play roles in various aging and neurodegenerative disease models across phyla.'], ['Understanding the spatiotemporal signaling of sex hormones in the brain can lead to more personalized prevention strategies or therapies combating neurodegenerative diseases.'], ["Hippocampal neurodegeneration, a primary component of Alzheimer's disease pathology, relates to poor cognition; however, the mechanisms underlying this relationship are not well understood."], ['Ribosome biogenesis is an essential, energy demanding process whose deregulation has been implicated in cancer, aging, and neurodegeneration.'], ['One way in which small vessel cerebrovascular disease could contribute to AD is through the promotion of neurodegeneration; the effect of small vessel cerebrovascular disease on neurodegeneration may differ across racial and ethnic groups.', 'Conclusions and Relevance: In this study, small vessel cerebrovascular disease, operationalized as WMH, was associated with subsequent cortical atrophy in regions that overlap with typical AD neurodegeneration patterns, particularly among non-Hispanic Black older adults.', 'Cerebrovascular disease may affect risk and progression of AD by promoting neurodegeneration and subsequent memory decline.'], ['Osteoporosis and neurodegenerative diseases are common diseases in the aging population.', 'Melatonin is a pharmaceutical ingredient in numerous medicines, over-the-counter medicines, nutraceuticals, and dietary supplements, which benefit disease prevention and treatment, including osteoporosis and neurodegenerative diseases.'], ['Recent discoveries of specific microbial taxa and microbial derived metabolites that modulate neuroinflammation and neurodegeneration have provided mechanistic insight into how the gut may modulate the CNS.'], ["Alzheimer's Disease (AD) is a progressive neurodegenerative disease strongly associated with increasing age."], ["BACKGROUND: Parkinson's disease (PD) is a chronic, disabling neurodegenerative disorder."], ['BACKGROUND: Parkinsonian syndromes are heterogeneous chronic neurodegenerative disorders associated with both motor and non-motor symptoms.'], ['The role of gender in brain health and whether women are at increased risk of neurodegenerative disorders leading to dementia are discussed.'], ['Cells expressing high levels of the cyclin-dependent kinase (CDK)4/6 inhibitor p16 (p16High ) accumulate in aging tissues and promote multiple age-related pathologies, including neurodegeneration.'], ['BACKGROUND: Mild cognitive impairment (MCI), as a common neurodegenerative aging disease representing an intermediate stage between normal cognitive functioning and dementia, poses an excessive burden on health care.'], ['Intestinal mucosal barrier dysfunction is an important contributor to metabolic diseases and has also been found to be involved in a variety of other chronic inflammatory conditions, including cancer, neurodegeneration, and aging.'], ['A recent diffusion-weighted imaging (DWI) method allows assessing cortical microstructure via cortical mean diffusivity (cMD), suggested to be more sensitive than macrostructural neurodegeneration.', 'Here, we aimed to investigate the association of cMD with amyloid-beta and tau pathology in older adults, and whether cMD predicts longitudinal cognitive decline, neurodegeneration and clinical progression.', 'Cortical microstructure is a noninvasive biomarker that independently predicts subsequent cognitive decline, neurodegeneration and clinical progression, suggesting utility in clinical trials.'], ["Age-related neurological disorders [ANDs] involve neurodegenerative diseases [NDDs] such as Alzheimer's disease [AD], the most frequent kind of dementia in elderly people, and Parkinson's disease [PD], and also other disorders like epilepsy and migraine."], ['In addition, changes in insulin signaling, caused inter alia insulin resistance, may accelerate brain aging, and affect plasticity and possibly neurodegeneration.'], ['Retinal chronic progressive neurodegeneration, which may occur among the elderly, can lead to different disorders of the eye such as glaucoma, age-related macular degeneration (AMD), and diabetic retinopathy (DR).', 'Typical neurodegenerative diseases of the CSN are a group of pathologies with common characteristics and etiology not fully understood; some risk factors have been identified, but they are not enough to justify all the cases observed.', 'Furthermore, several studies have shown that also ocular disorders present characteristics of neurodegenerative diseases and, on the other hand, CNS pathologies, i.e., Alzheimer disease (AD) and Parkinson disease (PD), which are causes of morbidity and mortality worldwide, show peculiar alterations at the ocular level.'], ["Identifying factors that drive microglial aging may thus be helpful to delay the onset of neurodegenerative diseases, such as Alzheimer's disease (AD)."], ['INTRODUCTION: Blood-based biomarkers of amyloid pathology and neurodegeneration are entering clinical use.', 'DISCUSSION: Multiple variables affect plasma biomarkers of amyloid pathology and neurodegeneration among CU in the general population.'], ["Alzheimer's disease (AD) is a central neurodegenerative disease generally among the elderly; it accounts for approximately 50-75%of total cases of dementia patients and poses a serious threat to physical and mental health."], ['Aging is a biological process that occurs under normal conditions and in several chronic degenerative diseases.'], ['Neurodegenerative diseases and sarcopenia become more prevalent as individuals age and, therefore, represent a serious issue for the healthcare system.'], ["Alzheimer's disease (AD) is a complex neurodegenerative disease in the elderly and the most common cause of human dementia."], ['As endogenous DNA damage is known to contribute to several human diseases, including neurodegeneration, immunodeficiencies, cancer, and aging, the ability of BRD proteins to suppress DNA damage and mutations is likely to provide new insights into the involvement of BRD proteins in these diseases.'], ['The CISD2 (NAF-1) protein plays a key role in regulating cellular homeostasis, aging, cancer and neurodegenerative diseases.'], ['Intervertebral disc degeneration (IDD) is a chronic skeletal muscle degenerative disease, which is considered the main cause of low back pain.', 'Although IDD is considered a natural process in degenerative lesions, it is mainly caused by aging, trauma, genetic susceptibility and other factors.'], ["BACKGROUND: Parkinson's disease (PD) is a common neurodegenerative disease in the elderly population."], ['Loss of this metabolic regulation has been proposed to be a contributor to memory dysfunction associated with neurodegeneration.', 'Within the above scenario, this review will focus on the interplay among oxidative stress (OS), insulin resistance and AMPK dysfunctions in the brain by highlighting how these neurotoxic events contribute to neurodegeneration.'], ['METHODS: The unweighted analytical sample included 1514 Americans aged >= 65 years that were identified as having a CICD without history of stroke, cancers, neurological conditions, or brain damage who participated in at least one-wave of the 2010-2016 waves of the Health and Retirement Study.'], ['The transcriptional repressor RE1-silencing transcription factor (REST) has been associated with aging and higher risk of neurodegenerative disorders.'], ['Indeed, it also universally promotes axon evolution, nervous migration, plasticity as well, it is suggested to be neuroprotective against neurodegenerative diseases.', "Moreover, miRNA-132/212 disorder leads to neural developmental perturbation, and the development of degenerative disorders covering Alzheimer's, Parkinson's, and epilepsy's along with psychiatric perturbations including schizophrenia."], ['In preclinical models, NAD+ repletion extends healthspan and / or lifespan and mitigates several conditions, such as premature ageing diseases and neurodegenerative diseases.', 'In summary, NAD+ precursors have an exciting therapeutic potential for ageing, metabolic and neurodegenerative diseases.'], ['Growing number of studies propose a potential link between periodontitis and neurodegeneration.'], ['CONCLUSION: A HFSS-combined diet caused motor-muscular and sensory dysfunctions, neuroinflammation, and neurodegeneration, whereas metformin counteracted these effects.'], ['miRNA-146a is significantly over-expressed in progressive and often lethal viral- and prion-mediated and related neurological syndromes associated with progressive inflammatory neurodegeneration.', 'In this report, we review the recent data supporting the idea that miRNA-146a may represent a novel and unique sncRNA-based biomarker for inflammatory neurodegeneration in multiple species.'], ['Neuroprotection from oxidative stress is critical during neuronal development and maintenance but also plays a major role in the pathogenesis and potential treatment of various neurological disorders and neurodegenerative diseases.', 'The present study provides deeper insights into plasma-mediated neuroprotection ultimately resulting in the development of novel therapies for a variety of neurological and, in particular, neurodegenerative diseases.'], ["Fragile X-associated tremor/ataxia syndrome (FXTAS) is a neurodegenerative disorder affecting subjects (premutation carriers) with a 55-200 CGG-trinucleotide expansion in the 5'UTR of the fragile X mental retardation 1 gene (FMR1) typically after age 50."], ['Intriguingly mtDNA is potentially exposed to DNA damage that has been attributed to a variety of human diseases, including neurodegeneration, cancer, and premature aging.'], ['Degenerative spinal disease that may require surgical intervention is also prevalent in this susceptible population.'], ['Accordingly, dysregulation of autophagy is closely associated with many human pathophysiological conditions, such as neurodegenerative diseases, aging, and cancer, and autophagy is highlighted as an important therapeutic target for these human diseases.'], ['ETHNOPHARMACOLOGICAL RELEVANCE: Age-related macular degeneration (AMD) is a chronic neurodegenerative disease which causes irreversible central vision loss among the elderly population.'], ["Demonstration of the effectiveness of such technology makes it possible to diffuse its use across all rural areas ('medical deserts') and thus, to improve the early diagnosis of neurodegenerative pathologies, while providing data crucial for basic research."], ["Alzheimer's disease (AD) is a neurodegenerative disease characterized by progressive memory dysfunction and cognitive decline."], ['Interest in NM has revived in recent years due to the alleged link between NM and the particular vulnerability of neuromelanin-containing neurons to neurodegeneration.'], ['Neurodegenerative diseases cause severe impairments in cognitive and motor function.', 'While age and longevity are the main risk factors for neurodegenerative diseases, sex is also an important risk factor.', 'mAR can mediate nicotinamide adenine dinucleotide-phosphate (NADPH) oxidase (NOX)-generated oxidative stress that is associated with several neurodegenerative diseases, such as Alzheimer disease.', 'Understanding of these signaling cascades could provide therapeutic targets for neurodegenerative diseases.'], ["The amyloid beta (Abeta) peptide is believed to play a central role in Alzheimer's disease (AD), the most common age-related neurodegenerative disorder."], ['Declines in mitochondrial proteostasis have been linked to cancer, aging, neurodegeneration, and many other diseases.'], ['A-T is characterized by chronic inflammation, neurodegeneration and premature ageing features that are associated with increased genome instability, nuclear shape alterations, micronuclei accumulation, neuronal defects and premature entry into cellular senescence.', 'We further demonstrate that cGAS and STING inhibition effectively suppresses self-DNA-triggered SASP expression in A-T brain organoids, inhibits astrocyte senescence and neurodegeneration, and ameliorates A-T brain organoid neuropathology.'], ["Alzheimer's disease (AD) is one of the most prevalent neurodegenerative diseases with motor disturbances, cognitive decline, and behavioral impairment.", 'Alpha-lipoic acid (alpha-LA), a natural antioxidant present in food and used as a dietary supplement, has been considered a promising agent for the prevention or treatment of neurodegenerative disorders.', 'The review article aimed at summarizing and discussing the main studies investigating the neuroprotective effects of alpha-LA on cognition as well as its molecular effects, to improve the understanding of the therapeutic potential of alpha-LA in patients suffering from neurodegenerative disorders, supporting the development of clinical trials with alpha-LA.'], ['Age-related macular degeneration (AMD), the leading cause of vision loss in the elderly, is a degenerative disease of the macula, where retinal pigment epithelium (RPE) cells are damaged in the early stages of the disease, and chronic inflammatory processes may be involved.'], ['The impacts of menopause on neurodegenerative diseases, especially the changes in steroid hormones, have been well described in cell models, animal models, and humans.', 'However, the therapeutic effects of hormone replacement therapy on postmenopausal women with neurodegenerative diseases remain controversial.'], ["Alzheimer's disease (AD) is the most prevalent neurodegenerative disease in the elderly."], ["Cumulative studies have recently indicated the neuroprotective role of EPO in preclinical models of acute and chronic neurodegenerative disorders, including Alzheimer's disease (AD)."], ["BACKGROUND: Parkinson's Disease (PD) is a highly prevalent neurodegenerative disease whose incidence is increasing with an aging population."], ["In addition, it has been associated with less age-related cognitive dysfunction and lower incidence of neurodegenerative disorders, particularly Alzheimer's disease."], ['CONCLUSION: The prevalence of chronic neurodegenerative diseases, in particular AD, is currently increasing.'], ['Plasma neurofilament light (NfL) is a marker for neurodegenerative diseases.'], ["INTERPRETATION: Both p-tau217 and p-tau181 had excellent diagnostic performance for differentiating patients with Alzheimer's disease syndromes from other neurodegenerative disorders."], ['Machado-Joseph disease (MJD, also known as spinocerebellar ataxia type 3) is a fatal neurodegenerative disease that impairs control and coordination of movement.', 'Further, they indicate that drugs that target the sirtuin pathway, including sodium valproate and resveratrol, warrant further investigation for the treatment of MJD and related neurodegenerative diseases.'], ["Alzheimer's disease is a neurodegenerative disorder of the elderly described by progressive cognitive debility."], ['Although the mechanisms of action of PGRN are currently unknown, its potential therapeutic application in treating neurodegenerative diseases is huge.'], ["Parkinson's disease is one of the most common neurodegenerative diseases in the elderly population, with a pathophysiology linked to neuroinflammation, complement activation, and oxidative damage.", "Thus, our data demonstrate that polySia avDP20 ameliorates inflammatory dopaminergic neurodegeneration and therefore is a promising drug candidate to prevent Parkinson's disease-related inflammation and neurodegeneration."], ['Deficits in adult neurogenesis may contribute to the aetiology of many neurodevelopmental, psychiatric and neurodegenerative diseases.', 'In this review, we discuss emerging molecular mechanisms underlying AHN that could be embraced in drug discovery to generate novel concepts and targets to treat diseases of ageing including neurodegeneration.'], ['Previous studies indicate that impaired Sonic hedgehog (Shh) signaling contributes to neurological phenotypes associated with DS and neurodegenerative diseases.'], ['BACKGROUND: As common, progressive, and chronic causes of disability and death, neurodegenerative diseases (NDDs) significantly threaten human health, while no effective treatment is available.', 'Given the engagement of multiple dysregulated pathways in neurodegeneration, there is an imperative need to target the axis and provide effective/multi-target agents to tackle neurodegeneration.', 'Two independent investigators followed the PRISMA guidelines and included papers on PI3K/Akt/mTOR and interconnected pathways/mediators targeted by phytochemicals in NDDs.', 'Amongst the emerging targets in neurodegeneration, PI3K/Akt/mTOR is of great importance.', 'Therefore, attenuation of these mediators would be a great step towards neuroprotection in such NDDs.'], ['Huntington disease (HD) is a neurodegenerative disorder caused by a CAG expansion in the HTT gene that codes for an elongated polyglutamine tract in the huntingtin (HTT) protein.'], ['Previous sequencing studies have demonstrated that aging alters gene expression in the PFC, however the extent to which these changes are conserved across species and are meaningful in neurodegeneration is unknown.'], ['Alzheimer disease (AD) is a progressive neurodegenerative disease causing cognitive decline in the aging population.'], ['Most neurodegenerative disorders afflict the ageing population and are often incurable.'], ['Dysregulated mechanisms of the autophagy pathway have been attributed to the etiopathogenesis of various disorders, including neurodegenerative disorders, malignancies, infections, and even aging.'], ['The evidence that the old population is steadily increasing and will triplicate in the next 50 years, together with the fact the elderlies are more prone to develop pathologies such as cancer, diabetes, and degenerative disorders, stimulates an important effort in finding specific countermeasures.'], ['Receiver operator characteristic curves assessed the ability of the FBB to discriminate individuals with frontal lobe features due to a neurodegenerative disease.'], ['Neurodegenerative diseases affect millions of people worldwide and are characterized by the chronic and progressive deterioration of neural function.', "Neurodegenerative diseases, such as Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS), and Huntington's disease (HD), represent a huge social and economic burden due to increasing prevalence in our aging society, severity of symptoms, and lack of effective disease-modifying therapies.", 'Modeling neurodegenerative diseases is difficult because of poor access to human samples (restricted in general to postmortem tissue) and limited knowledge of disease mechanisms in a human context.', 'The advent of human-induced pluripotent stem cell (hiPSC) technology presents an advantageous system that complements animal models of neurodegenerative diseases.'], ['AD is a multifactorial neurodegenerative disease.'], ['Most importantly, this review will answer questions such as whether there is any link between senescent microglia and age-related poor quality sleep and how this exacerbates neurodegenerative disease.'], ['Emerging evidence indicates that cellular senescence could be a critical inducing factor for aging-associated neurodegenerative disorders.'], ['Notwithstanding, a notorious number of recent studies support the use of these drugs to treat very diverse conditions, ranging from cancer to neurodegenerative or mitochondrial diseases.'], ['Neurodegeneration is the most common disease in the elderly population due to its slowly progressive nature of neuronal deterioration, eventually leading to executive dysfunction.', 'This review summarizes different optimization approaches of AAV vectors with their current applications in disease modeling, neural tracing and gene therapy, hence exploring progressive mechanisms of neurodegenerative diseases as well as effective therapy.'], ["Background: Parkinson's Disease (PD) is the second-most common neurodegenerative disease affecting the elderly population."], ['The study of energy metabolic pathways is a major focus within neuroscience research, which is supported by genetic defects in the oxidative phosphorylation mechanism often contributing towards neurodevelopmental disorders and changes in glucose metabolism presenting as a hallmark feature in age-dependent neurodegenerative disorders.', "We further summarize research pertaining to the interplay between metabolic alterations and neurodevelopmental and psychiatric disorders, and expose how an improved understanding of metabolic cell fate control might assist in the development of new concepts to combat age-dependent neurodegenerative diseases, particularly Alzheimer's disease."], ['Many neuro-degenerative diseases are difficult to diagnose in their early stages.'], ["Alzheimer's is a degenerative brain disease with an unspecified cause and pathogenesis which primarily affects older people."], ["Alzheimer's disease is a common progressive neurodegenerative disorder in the elderly."], ["Parkinson's disease (PD) is the second most common neurodegenerative disorder among the elderly, the diagnostic and prognostic of which is based mostly on clinical signs."], ['Alterations in olfactory functions are proposed to be early biomarkers for neurodegeneration.', "Many neurodegenerative diseases are age-related, including two of the most common, Parkinson's disease (PD) and Alzheimer's disease (AD).", 'The utility of OD as a biomarker for neurodegenerative disease diagnosis and future research directions are also discussed.'], ['Progressive aging is a physiological process that represents a central risk factor for the development of several human age-associated chronic diseases, including neurodegenerative diseases.', 'In this chapter, we introduce direct conversion as a practical and easy-to-approach disease model for aging and neurodegenerative disease research.'], ['Neurodegenerative movement disorders (NMDs) are age-dependent disorders that are characterised by the degeneration and loss of neurons, typically accompanied by pathological accumulation of different protein aggregates in the brain, which lead to motor symptoms.', "NMDs include Parkinson's disease, multiple system atrophy, progressive supranuclear palsy, and Huntington's disease, among others.", 'Epigenetic modifications are responsible for functional gene regulation during development, adult life and ageing and have progressively been implicated in complex diseases such as cancer and more recently in neurodegenerative diseases, such as NMDs.', 'Although this research field is still in its infancy in relation to NMDs, an increasing number of studies point towards a role for DNA methylation in disease processes.', 'This review addresses recent advances in epigenetic and epigenomic research in NMDs, with a focus on human brain DNA methylation studies.'], ['BACKGROUND: Osteoarthritis (OA) is a chronic degenerative disease that suppresses middle-aged and older people worldwide.', 'Silent information regulator 1(SIRT-1) is associated with several age-related diseases, such as cardiovascular diseases, neurodegenerative diseases and tumors, etc.'], ['STUDY OBJECTIVES: To identify the association between insomnia symptoms and signs of prodromal neurodegeneration, including an analysis of potential differences between sleep-onset and sleep-maintenance insomnia.'], ['BACKGROUND: Dysphagia can result from shock, trauma, aging, head and neck neoplasms, and some cerebrovascular diseases or neuromotor degenerative disorders.'], ['Aging is the major risk factor for neurodegenerative diseases and affects neurite distributions throughout the brain, yet underlying neurobiological mechanisms remain unclear.', 'In this study, neurite distributions were evaluated in the cortex and white matter in healthy older adults and patients with amnestic mild cognitive impairment (aMCI) that provides fundamental contributions regarding healthy aging and neurodegeneration.'], ['A pioneering body of work has defined the requirement of ATG7 for survival in mice and shown that neural-specific atg7 deletion causes neurodegeneration, but it has not been ascertained whether human life is compatible with ATG7 dysfunction.'], ['To date, there is limited knowledge on their expression in human brain or their involvement in brain aging and neurodegeneration.', 'The aim of this study was to characterise the expression levels of perilipins (Plin1-Plin5) in different cerebral areas from subjects of different age, with or without signs of neurodegeneration.', 'METHODS: We performed real-time RT-PCR, western blotting, immunohistochemistry and confocal microscopy analyses in autoptic brain samples of frontal and temporal cortex, cerebellum and hippocampus from subjects ranging from 33 to 104 years of age, with or without histological signs of neurodegeneration.', 'CONCLUSIONS: Perilipins are expressed in human brain but only Plin2 appears to be modulated with age and neurodegeneration and linked to an inflammatory state.', 'We propose that the accumulation of lipid droplets decorated with Plin2 occurs during brain aging and that this accumulation may be an early marker and initial step of inflammation and neurodegeneration.'], ['In conclusion, our model shows an ability to separate age, disease influence and anatomy using only 2D cross-sectional data that should be useful in large studies into neurodegenerative disease, that aim to combine several data sources.'], ["Many studies have shown that telomere shortening is associated with aging-related diseases, such as cardiovascular diseases, hypertension, diabetes, cancer, and various neurodegenerative diseases, including Alzheimer's disease, vascular dementia, Parkinson's disease, and dementia with Lewy bodies."], ['In this study, we investigate if telomere shortening and immune activation markers are associated with SCA, which is one of the main degenerative diseases in young HIV-infected adults.'], ["The aim of the present study was to investigate to what extent DM could impact on neurodegeneration within the AD continuum, using beta amyloid (A: Abeta1-42 ) and phosphorylated tau (T: p-tau) biomarkers to discriminate patients by Alzheimer's pathological change (A+/T-) and AD (A+/T+), according to the National Institute on Aging and Alzheimer's Association classification."], ['Objective: To conduct a head-to-head comparison of plasma p-tau181 and p-tau231 measured on the single-molecule array (Simoa) platform and p-tau181 and p-tau217 measured on the Meso Scale Discovery (MSD) platform on amyloid and tau positron emission tomography (PET) measures, neurodegeneration, vascular pathology, and cognitive outcomes.'], ['DISCUSSION: Insomnia symptom severity was associated with worse subsequent global cognitive and memory performance, which was especially apparent in APOE epsilon4 allele carriers, suggesting that poor sleep might be particularly detrimental when the brain is already vulnerable to neurodegeneration.'], ['Even after the symptoms of TBI are resolved, insidious molecular processes continue to develop, which often ultimately result in the development of age-associated neurodegenerative disorders.'], ["FUNDING: AC Immune, La Caixa Foundation, Instituto de Salud Carlos III, National Institute on Aging, Wellcome Trust, Jerome Lejeune Foundation, Medical Research Council, National Institute for Health Research, EU Joint Programme-Neurodegenerative Disease Research, Alzheimer's society, Deutsche Forschungsgemeinschaft, Stiftung fur die Erforschung von Verhaltens und Umwelteinflussen auf die menschliche Gesundheit, and NHS National Institute of Health Research Applied Research Collaborations East of England, UK."], ["Mitochondrial dysfunction is found in the brain and peripheral tissues of patients diagnosed with Huntington's disease (HD), an irreversible neurodegenerative disease of which aging is a major risk factor."], ['FUNDING: National Institute on Aging, Eunice Kennedy Shriver National Institute of Child Health and Human Development, German Center for Neurodegenerative Diseases, and Japan Agency for Medical Research and Development.'], ['Age-related macular degeneration (AMD) is a complex multifactorial neurodegenerative disease that constitutes the most common cause of irreversible blindness in the elderly in the developed countries.'], ['Chronic neurodegenerative diseases are complex, and their pathogenesis is uncertain.', 'Exogeneous viruses or other microbes and environmental pollutants may directly induce neurodegeneration by activating brain inflammation.', 'Chronic HERV activation in turn may cause progressive neurodegeneration that thereafter merges in cognitive impairment and dementia in genetically susceptible people.'], ["BACKGROUND AND PURPOSE: Parkinson's disease (PD) is a severe neurodegenerative disease with high morbidity in the elderly population."], ['OBJECTIVE: Late-life changes in cognition and brain integrity are both highly multivariate, time-dependent processes that are essential for understanding cognitive aging and neurodegenerative disease outcomes.'], ['The dopamine receptor-related loci have been suggested to be associated with cognitive functions and neurodegenerative diseases.'], ['Several genes associated with human brain diseases play a protective role in infection, suggesting the relevance of AP in the context of brain aging and neurodegeneration.'], ['Age-related brain iron accumulation is linked with oxidative stress, neurodegeneration and cognitive decline.'], ['Accordingly, abnormalities in the autophagic flux may contribute to many different pathophysiological conditions associated with ageing, including neurodegeneration.', 'Recent data have shown that extra-virgin olive oil (EVOO) polyphenols stimulate cell defenses against plaque-induced neurodegeneration, mainly, through autophagy induction.', '(4) Conclusion: Our results support the idea that EVOO polyphenols act synergistically in autophagy modulation against neurodegeneration.', 'These data confirm and provide the rationale to consider these molecules, alone or in combination, as promising candidates to contrast ageing-associated neurodegeneration.'], ['For this reason, spices have been studied as beneficial sources against neurodegenerative diseases, including AD.', 'In addition, the recommendations and prescriptions of these spices are still permeated by questioning and lack of robust evidence of their effects on neurodegeneration.'], ['Vagus somatosensory evoked potentials (VSEP) and ultrasonography can be used to detect functional and structural changes of the vagus nerve (VN) that are hypothesized to be associated with neurodegenerative diseases.'], ["Resting-state functional magnetic resonance imaging measures pathological alterations in neurodegenerative diseases, including Alzheimer's disease."], ['KEY POINTS: Amyotrophic lateral sclerosis (ALS) is an incurable neurodegenerative disorder of motor neurons, carrying a short survival.', 'ABSTRACT: Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder with a median survival of 3 years.'], ['Our data show that changes in tau and biomarkers of neurodegeneration in the CSF are associated with delirium severity.'], ['Social and economic impacts of neurodegenerative diseases (NDs) become more prominent in our constantly aging population.'], ['Increasing evidence suggests that dysfunction of autophagy is associated with a variety of human pathologies, including aging, cancer, neurodegenerative diseases, heart diseases, diabetes, and other metabolic diseases.'], ['CONCLUSIONS: In China, rheumatic heart disease was still the major cause of the VHD, with a significant increase in degenerative heart disease.'], ['Dual-phase [18F]AV45 positron emission tomography (PET) is highly promising in the assessment of neurodegenerative diseases, allowing to obtain information on both neurodegeneration (early-phase; eAV45) and amyloid deposition (late-phase; lAV45) which are highly complementary; yet eAV45 needs further evaluation.', 'These findings highlight the optimal use of eAV45 to assess neurodegeneration as a validated proxy of [18F]FDG PET.'], ["BACKGROUND: Alzheimer's disease (AD) is a fatal neurodegenerative disorder, and the lesions originate in the entorhinal cortex (EC) and hippocampus (HIP) at the early stage of AD progression."], ['Age-related macular degeneration (AMD), a degenerative disease of the outer retina, is the leading cause of blindness among the elderly.'], ['Lobar cerebral microbleeds (CMBs) and localized non-hemorrhage iron deposits in the basal ganglia have been associated with brain aging, vascular disease and neurodegenerative disorders.'], ["Age-related changes in cellular metabolism can affect brain homeostasis, creating conditions that are permissive to the onset and progression of neurodegenerative disorders such as Alzheimer's and Parkinson's diseases.", 'Taken together, our findings provide a link between metabolite homeostasis and protein homeostasis, which could inspire preventative interventions against neurodegenerative disorders.'], ['This mediation remained evident after controlling for motor abilities and neurodegenerative and vascular brain pathologies.'], ['Aging is one of the most common causes of various neurodegenerative diseases and the perception of environmental cues is also found to regulate the development of neurodegenerative phenotype in several animal models.'], ["Decades of postmortem histology research have demonstrated that the BF cholinergic neurons are selectively vulnerable to aging and age-related neuropathology in degenerative diseases such as Alzheimer's and Parkinson's diseases.", 'Emerging evidence from in vivo neuroimaging research, which permits longitudinal tracking of at-risk individuals, indicates that cholinergic neurodegeneration might play an earlier and more pivotal role in these diseases than was previously appreciated.'], ['Interactions between prion protein (PrP) and tau protein have long been discussed, especially in relation to the pathogenesis of neurodegenerative diseases.'], ['This study determined the prevalence and distribution of neurodegenerative proteinopathies in patients with infection-induced acute or chronic inflammation associated with herpes simplex virus (HSV) encephalitis (n = 13) and neurosyphilis (n = 23).', 'These observations provide insights into deposition of neurodegenerative proteins in neuroinfections, which might have implications for COVID-19 patients with chronic and/or post-infectious neurological symptoms and encephalitis.'], ['CONCLUSION: Although further research with a larger sample size is needed to elucidate the relationships between CDKN2A gene expression in blood and the development of other neurodegenerative diseases, CDKN2A mRNA expression in blood may be a biomarker for differentiating AD from normal aging and other neurodegenerative diseases.'], ['Progressive neurodegenerative diseases represent some of the largest growing treatment challenges for public health in modern society.', "The lack of efficacious treatment options for Alzheimer's disease (AD), as the focus of this review, and other neurodegenerative disorders has encouraged new approaches to address neuroinflammation for potential treatments.", 'Neuroinflammation is the common thread associated with neurodegenerative diseases, but it is yet unknown at what point and how innate immune function turns pathogenic for an individual.', 'This approach is still in its infancy in substantive clinical trials and requires thorough human studies to elucidate the metabolic microbiome profile to design appropriate treatment strategies for early stages of neurodegenerative disease.'], ['Cu imbalance is strongly associated with neurodegeneration in dementia, but a complete biochemical etiology consistent with the clinical, chemical, and genetic data is required to support a causative association, rather than just correlation with disease.'], ['BACKGROUND: Cognitively-defined subgroups are well-documented within neurodegeneration.', 'OBJECTIVE: We examined such profiles in diverse non-demented older adults and considered how resulting subgroups relate to modifiable factors associated with neurodegeneration.', 'CONCLUSION: LPA revealed two average subgroups reflecting level differences in cognition previously reported between non-Latino White and Black adults, and two lower cognition subgroups in domains similar to those documented in neurodegeneration.'], ["In addition, aging and neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease, have become topics of intense interest in biomedical research.", 'But the exact relationship between neurodegenerative diseases and gut microbiota remains unclear.', 'This article summarizes the known interactions between the gut microbiome and neurodegenerative diseases, highlighting assay techniques for the gut microbiome, and we also discuss the potential therapeutic role of microbiome-based therapies in diseases.'], ["BACKGROUND: Parkinson's disease (PD) is a progressive neurodegenerative disease with no cure and few treatment options.", 'Improvements were maintained for as long as treatment continued, for up to one year in a neurodegenerative disease where decline is typically expected.'], ['OBJECTIVE: To assess the role of biomarkers of Alzheimer disease (AD), neurodegeneration, and small vessel disease (SVD) as mediators in the association between diabetes mellitus and cognition.', 'We used structural equation modeling to assess whether latent variables of AD pathology (PET mean amyloid uptake, Abeta42/Abeta40 ratio, and CSF phosphorylated tau), SVD (white matter hyperintensities volume and visual grading), and neurodegeneration (mean cortical thickness, brain parenchymal fraction, hippocampal volume, and mean fluorodeoxyglucose uptake) mediate the association between diabetes and a latent variable of cognition (5 neuropsychological tests), adjusting for potential confounders.', 'The association between diabetes and lower cognition was significantly mediated by higher neurodegeneration (standardized indirect effect: -0.061, 95% confidence interval: -0.089, -0.032), but not mediated by SVD and AD markers.', 'CONCLUSION: In a large clinical cohort in the elderly, diabetes is associated with lower cognition through neurodegeneration, independently of SVD and AD biomarkers.'], ['Exploring aging-related reorganization of the brain modular architecture using metabolic brain network could further our understanding about aging-related neuromechanism and neurodegenerations.'], ['In rodent models, removal of the olfactory bulb results in pathology of the frontal cortex that shows striking similarity with frontal cortex features of patients diagnosed with neurodegenerative disorders.', 'Widely different approaches involving behavioral symptom analysis, histopathological and molecular alterations, genetic and environmental influences, along with age-related alterations in cellular pathways, indicate a strong correlation of olfactory dysfunction and neurodegeneration.', 'Indeed, declining olfactory acuity and olfactory deficits emerge either as the very first symptoms or as prodromal symptoms of progressing neurodegeneration of classical conditions.', 'Here, we review findings that olfactory bulb neuronal processing serves as a marker of neuropsychiatric and neurodegenerative disorders.'], ["Neurodegenerative diseases, e.g., Alzheimer's disease (AD), are a key health problem in the aging population.", 'Increased activity of these enzymes, especially butyrylcholinesterase (BuChE), is observed in neurodegenerative diseases.'], ["The aim of this review is to summarize the main hallmarks of aging processes and certain signaling pathways in association with (putative) beneficial influences of exogenous ketogenic supplements-evoked ketosis on lifespan, aging processes, the most common age-related neurodegenerative diseases (Alzheimer's disease, Parkinson's disease and amyotrophic lateral sclerosis), as well as impaired learning and memory functions."], ['After the Seven Countries Study, many prospective observational studies and trials in diverse populations reinforced the beneficial effects associated with a higher adherence to the Mediterranean diet in reference to the prevention/management of age-associated non-communicable diseases, such as cardiovascular and metabolic diseases, neurodegenerative diseases, cancer, depression, respiratory diseases, and fragility fractures.'], ["Alzheimer's disease (AD), the most common cause of dementia in the elderly, is a neurodegenerative disorder associated with neurovascular dysfunction and cognitive decline."], ['Except for WS, a common trait of the aforementioned progerias is neurodegeneration.'], ["The relation between HHcy and the development of neurodegenerative diseases, such as Alzheimer's disease (AD) and eye diseases, and age-related macular degeneration (AMD) and diabetic retinopathy (DR) in elderly people, has been established.", 'Disruption of the blood barrier function of the brain and retina is one of the most important underlying mechanisms associated with HHcy-induced neurodegenerative and retinal disorders.'], ['Here, a complex neurodegenerative disease-known locally as lytico-bodig and medically as amyotrophic lateral sclerosis and Parkinsonism-dementia complex (ALS/PDC)-reached hyperendemic proportions in the mid-twentieth century but then declined and is now disappearing.'], ['Neurodegenerative disorders affect millions of people and are characterized by cognitive decline and locomotor deficits.', 'Drosophila melanogaster is an emerging neurodegeneration model due to its versatility as a tool for genetic studies.', 'In this Review, we overview cell competition and the new insights related to neurodegenerative disorders, and discuss how research in the field might contribute to the development of new therapeutic targets for these diseases.'], ["Using established AD cut-points for the cerebrospinal fluid concentrations of Abeta42, total-tau and p-tau181, subjects were classified according to the National Institute on Aging-Alzheimer's Association research framework, grouping markers into those of Abeta deposition (A), tau pathology (T) and neurodegeneration (N)."], ['Compromise of the vascular system has important consequences on cognitive abilities and neurodegeneration.'], ['Understanding the phagocytic code, and how it goes wrong, may enable novel therapies for multiple pathologies with too much or too little phagocytosis, such as: infectious disease, cancer, neurodegeneration, psychiatric disease, cardiovascular disease, ageing and auto-immune disease.'], ['The epidemiology of VHD varies substantially around the world, with a predominance of functional and degenerative disease in high-income countries, and a predominance of rheumatic heart disease in low-income and middle-income countries.'], ['RESULTS: 286 aging (ageing) genes and a wide spectrum of 96 associated phenotypes were detected, including late-onset neurodegenerative disorders, cancers, osteoarthritis, and longevity.'], ['Overall, our findings provide evidence of the critical necessity for bespoke clocks of brain aging for advancing research to understand, and eventually prevent, neurodegenerative diseases of aging.'], ['We propose that chronic "degenerative excitotoxicity" leads to sporadic AD, while GluN3A represents a primary pathogenic factor, an early biomarker, and an amyloid-independent therapeutic target.'], ['All COVID-19 cases showed non-SARS-CoV-2-specific changes including hypoxic-agonal alterations, and a variable degree of neurodegeneration and/or pre-existent SVD.', "Although higher in cases with both Alzheimer's pathology and COVID-19, cortical neuroinflammation is not related to COVID-19 per se but mostly to pre-existing neurodegeneration."], ["They are implicated in several neurodegenerative diseases like Alzheimer's and Parkinson's disease.", 'Our results demonstrate CD22 as a broad age-associated modulator of microglia functionality with potential implications for neurodegenerative disorders.'], ['Myelin loss and iron accumulation are cardinal features of aging and various neurodegenerative diseases.', "An emerging hypothesis in Alzheimer's disease research suggests that myelin breakdown releases substantial stores of iron that may accumulate, leading to further myelin breakdown and neurodegeneration.", 'This work establishes a foundation for further investigations of the etiology and sequelae of myelin breakdown and iron accumulation in neurodegeneration and may lead to new imaging markers for disease progression and treatment.'], ['BACKGROUND: Osteoarthritis is the most common degenerative disease of the synovial joints in the elderly population with hip osteoarthritis as the second most commonly affected joint.'], ['There is a need for further studies and well-designed clinical trials, with CoQ10 in a formulation of proven bioavailability, involving a greater number of participants undergoing longer treatments in order to assess the benefits of CoQ10 treatment in neurodegenerative disorders, as well as in metabolic syndrome and its complications.'], ["The National Institute on Aging and Alzheimer's Association (NIA-AA) A/T/(N) [beta-Amyloid/Tau/(Neurodegeneration)] AD research framework, which classifies research participants according to three binary biomarkers [beta-amyloid (A+/A-), tau (T+/T-), and neurodegeneration (N+/N-)], provides an indirect means of identifying such cases.", 'Individuals with A+T-(N+) MCI are thought to have both AD pathologic change, given the presence of beta-amyloid, and non-AD pathophysiology, given neurodegeneration without tau, because in typical AD it is tau accumulation that is most tightly linked to neuronal injury and cognitive decline.', 'Thus, in A+T-(N+) MCI (hereafter referred to as "mismatch MCI" for the tau-neurodegeneration mismatch), non-AD pathology is hypothesized to drive neurodegeneration and symptoms, because beta-amyloid, in the absence of tau, likely reflects a preclinical stage of AD.', 'We compared a group of individuals with mismatch MCI to groups with A+T+(N+) MCI (or "prodromal AD") and A-T-(N+) MCI (or "neurodegeneration-only MCI") on cross-sectional and longitudinal cognition and neuroimaging characteristics.', 'beta-amyloid and tau status were determined by CSF assays, while neurodegeneration status was based on hippocampal volume on MRI.', 'Overall, mismatch MCI was less "AD-like" than prodromal AD and generally, with some exceptions, more closely resembled the neurodegeneration-only group.', 'Longitudinally, mismatch MCI declined more slowly than prodromal AD across all included cognitive domains, while mismatch MCI and neurodegeneration-only MCI declined at comparable rates.', 'Prodromal AD had smaller baseline posterior hippocampal volume than mismatch MCI, and whole brain analyses demonstrated cortical thinning that was widespread in prodromal AD but largely restricted to the medial temporal lobes (MTLs) for the mismatch and neurodegeneration-only MCI groups.'], ['The accumulation of unrepaired DNA lesions is associated with many pathological outcomes in humans, particularly in neurodegenerative diseases and in normal aging.', 'Evidence supporting a causal role for DNA damage in the onset and progression of neurodegenerative disease has come from rare human patients with mutations in DNA damage response genes as well as from model organisms; however, the generality of this relationship in the normal population is unclear.', 'In addition, the relevance of DNA damage in the context of proteotoxic stress-the widely accepted paradigm for pathology during neurodegeneration-is not well understood.'], ['This reflects the spatio-temporal progression of neurodegeneration in AD.', 'This has implications for early detection of neurodegenerative diseases and the study of brain-behaviour relationships.'], ['The benefit of olaparib and other clinically approved PARP inhibitors has already been demonstrated in several experimental models of human diseases, such as neurodegeneration and neuroinflammation, acute hepatitis, skeletal muscle disorders, aging and acute ischemic stroke, protecting, for example, from the deterioration of the blood-brain barrier, restoring the cellular levels of NAD+, improving mitochondrial function and biogenesis and, among other effects, reducing oxidative stress and pro-inflammatory mediators, such as TNF-alpha, IL1-beta, IL-6, and VCAM1.'], ['Mitochondria have taken center stage in the research of normal and pathological processes, including normal tissue homeostasis and metabolism, neurodegeneration, immunity and infectious diseases.'], ["METHODS: We identified non-demented participants without neurodegenerative disease from the National Alzheimer's Coordinating Center Uniform Data Set who converted to DLB at a subsequent visit."], ['Despite remarkable advances, research into neurodegeneration and Alzheimer Disease (AD) has nonetheless been dominated by inconsistent and conflicting theory.', 'Using derivative models, we suggest that this endogenous aging process underpins the pathogenesis and spectrum of neurodegenerative disease.'], ['The rapid pattern of population ageing in recent years increases the risk of appearance of associated neurodegenerative diseases.'], ["Alzheimer's disease is a progressive, irreversible neurodegenerative disease impacting cognition, function, and behavior."], ["Alzheimer's disease is an irreversible neurodegenerative disease, which affects daily life activities and social functioning."], ['In the high-energy environment of the central nervous system, mitochondria contribute to neuroinflammation and aging, which may ultimately drive the pathogenesis of neurodegenerative diseases.'], ['We collected twenty-four post-mortem brain tissue datasets of 3871 and 1820 non-demented males and females, respectively, who died from causes not attributable to neurodegenerative diseases.'], ['Physical exercise benefits cognitive functioning and can protect against neurodegeneration.'], ["Amyloid-beta (Abeta) deposits, pathologic tau, and neurodegeneration are major pathological hallmarks of Alzheimer's disease (AD)."], ['Pharmacological reversal of brain aging is a long-sought yet challenging strategy for the prevention and treatment of age-related neurodegeneration, due to the diverse cell types and complex cellular pathways impacted by the aging process.', 'The age-related expression changes reversed by GLP-1RA encompass both shared and cell type-specific functional pathways that are implicated in aging and neurodegeneration.', 'These results show the feasibility of reversing brain aging by pharmacological means, provide mechanistic insights into the neurological benefits of GLP-1RAs, and imply that GLP-1R agonism may be a generally applicable pharmacological intervention for patients at risk of age-related neurodegeneration.'], ['The study aimed to investigate the relationship between mobile phone use and cognitive impairment using the data of the Prevention and Intervention on Neurodegenerative Disease for Elderly in China (PINDEC) survey.'], ['Osteoarthritis (OA) is a chronic degenerative disorder of the joint and its prevalence and severity is increasing owing to ageing of the population.'], ['Greatly impacted by their environment, microglia go through rapid changes in cell shape, gene expression, and functional behavior during states of infection, trauma, and neurodegeneration.', "Despite the scientific community's growing knowledge in the field of neuroinflammation, the overall success rate of drug treatment for age-related and neurodegenerative diseases remains incredibly low."], ['Moreover, lingonberry intake has been associated with a beneficial effect on preventing and treating brain aging and neurodegenerative disorders.'], ['In this context, research has uncovered relationships between cardiovascular disease (CVD) and the development of neurodegenerative diseases, suggesting that CHD can act as a precursor.'], ['Abdominal aortic aneurysm (AAA) is an age related degenerative vascular disorder, characterized by a progressive dilatation of the vascular wall and high risk of rupture over time.'], ['Nucleocytoplasmic transport (NCT) decline occurs with aging and neurodegeneration.'], ['The hippocampus plays a crucial role in learning and memory, and its progressive deterioration with age is functionally linked to a variety of human neurodegenerative diseases.', 'This rich resource for understanding primate hippocampal aging may provide potential diagnostic biomarkers and therapeutic interventions against age-related neurodegenerative diseases.'], ['Therefore, the effective UPR to internal and external causes is linked to the multiple pathophysiological conditions such as aging, immunity, and neurodegenerative diseases.'], ['The unfolded protein response (UPR) is the main pathway mediating adaptation to ER stress, but it can also trigger deleterious cascades of inflammation and cell death leading to cell dysfunction and neurodegeneration.', 'Whether the mechanisms uncovered in these models are relevant for the etiology of the vast majority of age-related sporadic forms of neurodegenerative diseases is an open question.', 'Furthermore, we highlight the recent association of metabolic syndrome to increased risk to undergo neurodegeneration, where ER stress arises as a common denominator in the pathogenic crosstalk between peripheral organs and the nervous system.'], ['Overall, most of the overlapping proteins were functionally associated with enhanced NMDA receptor mediated glutamatergic signaling, an excitotoxicity mechanism known to affect neurodegeneration.'], ['Neurodegenerative diseases (NDDs) are the primary cause of disabilities in the elderly people.', 'Growing evidence indicates that oxidative stress, mitochondrial dysfunction, neuroinflammation and apoptosis are associated with aging and the basis of most neurodegenerative disorders.', 'This review assesses the food sources of quercetin, its pharmacokinetic profile, structure activity relationship and its pathophysiological role in various NDDs and it also provides a synopsis of the literature exploring the relationship between quercetin and various downstream signalling pathways modulated by quercetin for neuroprotection for eg.', 'Therefore, the aim of the present review was to elaborate on the cellular and molecular mechanisms of the quercetin involved in the protection against NDDs.'], ['Knowledge that the structure of human cognition becomes less diversified and more dependent on general intelligence as a function of cognitive impairment should inform clinical assessment and care for these patients as their neurodegeneration progresses.'], ['Dysregulation of these processes may lead to an increase in phosphorylated TDP-43, ultimately contributing to neurotoxicity and neurodegeneration in disease.'], ['OBJECTIVES: To test the hypothesis that increased aortic stiffening is associated with greater CSF evidence of core Alzheimer disease pathology (beta-amyloid [Abeta], phosphorylated tau [p-tau]), neurodegeneration (total tau [t-tau]), synaptic dysfunction (neurogranin), neuroaxonal injury (neurofilament light [NFL]), and neuroinflammation (YKL-40, soluble triggering receptor expressed on myeloid cells 2 [sTREM2]), we analyzed pulse wave velocity (PWV) data and CSF data among older adults.', 'CONCLUSIONS: Among our oldest participants, >=74 years of age, greater aortic stiffening is associated with in vivo biomarker evidence of neuroinflammation, tau phosphorylation, synaptic dysfunction, and neurodegeneration, but not amyloidosis.', 'Central arterial stiffening may lead to cumulative cerebral microcirculatory damage and reduced blood flow delivery to tissue, resulting in neuroinflammation and neurodegeneration in more advanced age.'], ['We uncover pathways controlling neuronal response to chronic oxidative stress, which is implicated in neurodegenerative diseases.', 'We also determine transcriptomic changes in neurons after perturbation of genes linked to neurodegenerative diseases.'], ['As part of the Ontario Neurodegenerative Disease Research Initiative (ONDRI) and the Canadian Biomarker Integration Network in Depression (CAN-BIND), QA phantom scans were conducted approximately monthly for three to four years at 13 sites across Canada with 3T research MRI scanners.'], ['Exacerbated deposition of extracellular matrix components is a characteristic feature of human muscular dystrophies, neurodegenerative diseases affecting muscle and aging.'], ['The presence of tau or neurodegeneration in the absence of amyloid defines non-AD pathologic change.', 'OBJECTIVE: To examine the relation of in vivo amyloid and neurodegeneration with verbal learning, one of the cognitive abilities affected early in AD, in late middle age.', 'METHODS: This was a cross-sectional study of amyloid and neurodegeneration biomarkers in a community-based cohort of 350 late-middle aged Hispanics without dementia (mean age: 64.15+-3.34; 72.0%women).', 'Neurodegeneration (N) was ascertained as cortical thickness (CT) in AD signature areas using brain magnetic resonance imaging.'], ['METHODS: The weighted analytical sample included 6,036,224 Americans aged at least 65 years old that were identified as having a CICD without history of stroke, cancers, neurological conditions, or brain damage who participated in at least one-wave of the 2010-2016 Health and Retirement Study.'], ['OBJECTIVE: To examine the relationships between anxiety and amyloid-beta, tau deposition, and neurodegeneration.', 'RESULTS: There was a positive correlation between anxiety and amyloid-beta deposition (r = 0.11, p = 0.0017) and a negative correlation between anxiety and neurodegeneration (r = -0.13, p = 0.00022).', 'Non-anxious participants with more amyloid-beta deposition or more severe neurodegeneration displayed accelerated development into anxiety (HR = 2.352, p < 0.0001; HR = 2.254, p < 0.0001).', 'CONCLUSION: Anxiety was associated with amyloid-beta deposition and neurodegeneration in non-dementia elderly.'], ['As a result, aged microglia are no longer capable of establishing effective immune responses and sustaining normal synaptic activity, directly contributing to age-associated cognitive decline and neurodegeneration.'], ["Motivated by findings from neurodegenerative diseases and healthy aging, we tested whether 'motor-relatedness' (the degree to which words are associated with particular human body movements) might moderate such declines."], ['It is a progressive neurodegenerative disease wherein alpha-synuclein, a neuronal protein, aggregates to form toxic structures in nerve cells.'], ['BACKGROUND: Neurofilament light in serum (sNfL) is a biomarker for axonal damage with elevated levels in many neurological disorders, including neurodegenerative dementias.', 'SNfL was mostly helpful to neurologists in confirming or excluding neurodegeneration.', 'Based on our results, we recommend the analysis of the biomarker sNfL to confirm or exclude neurodegeneration in patients below 62 years old and in males.'], ['The project "Factors associated with healthy and pathologically aging in a sample of elderly people over 90 in the city of Madrid" (MADRID+90) brings together a multidisciplinary research team in neurodegenerative diseases that includes experts in epidemiology, neurology, neuropsychology, neuroimaging and computational neuroscience.'], ['STUDY OBJECTIVES: Slow wave and spindle coupling supports memory consolidation, and loss of coupling is linked with cognitive decline and neurodegeneration.'], ['Hence, agents that increase intracellular NAD+ could have beneficial effects in aging and age-related neurodegenerative diseases.', 'Here, we review emerging findings revealing key roles for NAD+ and related metabolites in experimental models of dopaminergic neurodegeneration and in PD patients.'], ['As concerns prospective timing, a first random-effect model showed a medium overall effect of neurodegeneration on timing performance.', 'Concerning retrospective timing, a significant but small effect of neurodegeneration was observed for retrospective judgments.'], ['Aging is the main risk factor for the most important degenerative diseases and this demographic shift poses significant social, economic, and medical challenges.'], ['As progressive, chronic, incurable and common reasons for disability and death, neurodegenerative diseases (NDDs) are significant threats to human health.', 'Besides, the increasing prevalence of neuronal gradual degeneration and death during NDDs has made them a global concern.', 'Since yet, no effective treatment has been developed to combat multiple dysregulated pathways/mediators and related complications in NDDs.', 'Growing studies have reported multiple dysregulated pathways in NDDs, which among those mediator AMP-activated protein kinase (AMPK) and peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha) play critical roles.', "In this line, critical role of flavonoids in the upregulation of AMPK/PGC-1alpha pathway seems to pave the road in the treatment of Alzheimer's disease (AD), Parkinson's disease (PD), aging, central nervous system (brain/spinal cord) damages, stroke, and other NDDs.", 'In the present study, the regulatory role of flavonoids in managing various NDDs has been shown to pass through AMPK/PGC-1alpha signaling pathway.'], ['Technological advances in nucleic acid sequencing have enabled recent breakthroughs that illuminate the roles of somatic mutations in aging and degenerative diseases of the brain.'], ["Alzheimer's disease is a common neurodegenerative disease in the elderly population and a leading cause of dementia."], ['It also remains unclear whether reductions in CBF accelerate neurodegeneration and development of small vessel cerebrovascular disease.'], ['Bioflavonoids have been used in the neurodegeneration and diabetes studies.'], ['Less than 10% of affected individuals will have a primary neurological disorder, for example, dementia, a neurodegenerative disease with varying aetiologies.', "MD occurs in patients with a neurodegenerative disorder, such as AD, Lewy body or Pick's disease and additionally cerebrovascular disease."], ['In addition, we find that flies reared on ethanol exhibit mild climbing defects suggestive of neurodegeneration.'], ["OBJECTIVE: Parkinson's disease (PD) is a chronic neurodegenerative disorder with increasing prevalence in the elderly."], ["Amyloid-beta (Abeta) plaques and tau neurofibrillary tangles are pathological hallmarks of Alzheimer's disease (AD); their contribution to neurodegeneration and clinical manifestations are critical in understanding preclinical AD."], ['BACKGROUND: Alzheimer disease (AD) is a progressive neurodegenerative disorder affecting the elderly with a prevalence of 7.1% in women and 3.3% in men.'], ['Progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD) are neuropathologic subtypes of frontotemporal lobar degeneration with tau inclusions (FTLD-tau), primary tauopathies in which intracellular tau aggregation contributes to neurodegeneration.'], ['We also show the emerging importance of their consumption in the prevention and management of crucial neurodegenerative conditions (alcohol-related brain disorders and aging) and in neuromuscular disorders (Spinal Muscular Atrophy and Amyotrophic Lateral Sclerosis and Duchenne Muscular Dystrophy), where oxidative stress plays a predominant role.'], ["BACKGROUND: Alzheimer's disease (AD) is a neurodegenerative disorder associated with extracellular amyloid-beta peptide deposition and progressive neuron loss."], ["These pathways have been shown to be critical for neurodegenerative disorders such as Alzheimer's disease and more in general for cognitive decline."], ['Growing evidence shows that piRNAs and PIWI proteins are abnormally expressed in various diseases, including cancers, neurodegenerative diseases and ageing, and may be potential biomarkers and therapeutic targets.'], ['Oxidative stress (OS) is one of the most significant propagators of systemic damage with implications for widespread pathologies such as vascular disease, accelerated aging, degenerative disease, inflammation, and traumatic injury.', 'Studies of OS in the brain, for example, have demonstrated how this state contributes to neurodegeneration and altered neural plasticity.'], ['Strength training for 6-12 weeks did not alter plasma IL-1beta, IL-2, IL-6 and TNF-alpha concentration in healthy elderly adults and patients with chronic-degenerative diseases, while 12 weeks of resistance training decreased muscle TNF-alpha mRNA in frail elderly individuals.'], ['Deep grey nuclei of the human brain accumulate minerals both in aging and in several neurodegenerative diseases.', 'In conclusion, the evidence of hypointensity in the caudate nucleus and thalamus at any age or hypointensity in the putamen seen in young subjects should prompt the clinician to consider a neurodegenerative disease.'], ['Seizures in epilepsy can also lead to cognitive deficits, neuroinflammation, and neurodegeneration.'], ["The derivation of human embryonic stem cells followed by the discovery of induced pluripotent stem cells and leaps in genome editing approaches have continuously fueled enthusiasm for the development of new models of neurodegenerative diseases such as Parkinson's disease (PD).", 'All of these contribute to specific vulnerability and, along with aging and environmental factors, might be integrated in a complex stressor-threshold model of neurodegeneration.'], ['Ageing represents the single biggest risk factor for development of neurodegenerative disease.'], ['Mitochondrial dysfunction is mechanistically linked to several neurodegenerative diseases, cancer, and ageing.'], ['It plays a crucial role in different molecular pathways linked to DNA repair, tumorigenesis, glycolysis, gluconeogenesis, neurodegeneration, cardiac hypertrophic responses, etc.', 'Thus, it has emerged as an exciting target of several diseases such as cancer, neurodegenerative diseases, aging, diabetes, metabolic disorder, and heart disease.'], ['Cockayne syndrome (CS) is a DNA repair syndrome characterized by a broad spectrum of clinical manifestations such as neurodegeneration, premature aging, developmental impairment, photosensitivity and other symptoms.'], ["Alzheimer's disease (AD) is a chronic, neurodegenerative brain disorder affecting millions of Americans that is expected to increase in incidence with the expanding aging population."], ["Both defective and excessive mitophagy have been proposed to contribute to age-related neurodegenerative diseases, such as Parkinson's and Alzheimer's diseases, metabolic diseases, vascular complications of diabetes, myocardial injury, muscle dystrophy, and liver disease, among others."], ['Furthermore, a reduction of nuclear Ca2+ levels has been shown to be neurotoxic and a causal factor driving the progression of neurodegenerative disorders, as well as affecting neuronal autophagy.'], ['We found sex differences in age-related DA neurodegeneration and its associated locomotor behavior, where males exhibit significantly greater decreases in both DA neuron number and locomotion during aging compared with females.', 'This offers a new mechanism for sex differences in selective DA neuron vulnerability to age-related DA neurodegeneration.', 'These findings lay the groundwork for the manipulation of DA neuron VGLUT expression as a novel therapeutic strategy to boost DA neuron resilience to age- and PD-related neurodegeneration.'], ['CONCLUSIONS: The present findings on MCR prevalence and associated cognitive and physical domains and inflammatory biomarkers may help to uncover altered pathways and therapeutic targets for intervention during the long preclinical phase of neurodegenerative dementia.'], ['Recent progress in cell-based therapy has greatly contributed to the amelioration of degenerative diseases related to age.'], ['Some natural leaves such as Moringa oleifera, curry leaves, guava leaves, green tea, olive leaves, Ginkgo biloba, thankuni leaves, grape leaves, vasaka leaves, and kulekhara leaves are found to have therapeutic effects against diseases like cancer, diabetes, immunosuppression, hepatic damage, and neurodegenerative disorders.'], ['Cognitive dysfunction is a degenerative disease of the central nervous system, which often associates with ageing brain as well as neurodegenerative diseases.'], ["It can be idiopathic, such as multisystemic atrophy or pure autonomic failure, or secondary to systemic pathologies such as diabetes mellitus, neurodegenerative diseases, Parkinson's disease, dementia syndromes, chronic renal failure, amyloidosis and it may also occur in the elderly."], ['These therapeutic agents possess the following multifunctionalities: (1) compared with frequently used aggregation inhibitors restricted by intrinsically feeble and sensitive noncovalent interactions, multifunctional agents can efficiently block Abeta aggregation by exploiting two or more Abeta-specific inhibition strategies simultaneously; (2) apart from regulating Abeta aggregation, multipronged agents can also target and modulate other pathological factors in AD pathogenesis, such as increased oxidative stress, abnormal copper accumulation, and irreversible neuron loss; (3) multifunctional platforms with both diagnostic and therapeutic modalities through integrating in situ imaging, real-time diagnostics, a multitarget direction, stimuli-responsive drug release, and the blood-brain barrier (BBB) translocation features are instrumental in improving drug levels at trouble sites, diminishing off-target adverse reactions, evaluating therapeutic effects, and averting overtreatment.Given the fact that amyloid aggregation, local inflammation, and metal dyshomeostasis are universal biomarkers shared by various neurodegenerative disorders, this Account provides a perspective for the evolution of customized therapeutic agents with multiple reactivities for other neurodegenerative diseases.'], ['An inverse correlation between the incidence of cancer and neurodegenerative disease has been observed, with the prevalence of cancer peaking around 60 years of age, then slowly tapering off as neurodegenerative diseases increase in the elderly.', 'Likewise, in neurodegenerative disease, a decrease in astrocyte density is observed in early disease states, and senescent astrocytes increase.', 'Because astrocytes coordinate synaptic function, astrocyte dysfunction likely contributes to or causes initial synapse loss and cognitive decline seen in neurodegenerative disease.', 'Disruption to this astrogenic balance could account for the inverse correlation of cell cycle dysregulation resulting in malignant astrocytes and tumorigenesis, and astrocytic senescence and cell death without self-renewal in aging resulting in neurodegenerative disease.'], ['METHODS: Seventy (N = 70) participants (M = 40.13, SD = 7.77 years) received baseline scans as part of the Neurodegeneration in Aging Down Syndrome (NiAD) study at two imaging facilities (36 at the University of Wisconsin-Madison [UW-Madison] and 34 at the University of Pittsburgh Medical Center [UPMC]).'], ["Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the most common form of dementia in the old age population, making it a worldwide concern.", 'Given conclusive scientific findings, saffron and its derivatives might counter neurodegenerative diseases through multiple pathways.'], ["Alzheimer's disease (AD) is by far the most prevalent neurodegenerative disease of aging and is a major burden for patients, caregivers, and the overall health care system."], ['Our data confirm that LOAD is a "multi-hit" disorder and provide evidence for innate inefficient cellular energy management in LOAD that likely predisposes to neurodegenerative disease with age.'], ['Physical activity (PA) demonstrated benefits on brain health, but its relationship with blood biomarkers of neurodegeneration remains poorly investigated.'], ['In conclusion, mTBI accelerates the brain-aging process, and brain-PAD may be capable of evaluating aging-associated issues post-injury, such as increased risks of neurodegeneration.'], ["Hypoxia is pivotal to the pathogeneses of myriad neurological disorders, including Alzheimer's, Parkinson's and other age-related neurodegenerative diseases.", 'Special attention is directed toward the risks vs. benefits of hypoxia exposure to the elderly, and potential therapeutic applications of hypoxia for neurodegenerative diseases.'], ['The latter are also dysregulated in clinical neurodegeneration, such as amyotrophic lateral sclerosis.', 'Here, we provide for the first time in vitro and in vivo evidence for a novel translatable approach to treat neurodegenerative disorders by modulating neurogenesis.'], ['Deregulation of autophagic processes is associated with cancer, neurodegeneration, muscle and heart disease, infectious diseases and aging.'], ['Both cognitive function and white matter (WM) structure are found to be associated with neurodegeneration diseases and correlated with sex during aging.'], ["METHODS: Within the 'Stability of home-based care arrangements for people living with dementia' project (SoCA project) at the German Center for Neurodegenerative Diseases (DZNE), we conducted a meta-study on mixed research."], ['Blocking GAPDH S-nitrosylation, inhibiting p300/CBP, or stimulating Sirtuin1 all protect mice from neurodegeneration, neurobehavioral impairment, and blood and brain accumulation of ac-tau after TBI.'], ['The amyloid precursor protein (APP) is a type I transmembrane protein with unknown physiological function but potential impact in neurodegeneration.'], ['Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease associated with exposure to repetitive head impacts, such as those from contact sports.', 'Neuroimaging is an integral component of the clinical evaluation of neurodegenerative diseases and will likely aid in diagnosing CTE during life.', 'Converging structural and functional imaging evidence together with neuropathological evidence show frontotemporal and medial temporal lobe neurodegeneration, and increased likelihood for a cavum septum pellucidum.'], ['The Mediterranean diet is appraised as the premier dietary regimen and its espousal is correlated with the prevention of degenerative diseases and extended longevity.'], ['Over the last few years there is growing interest in the relationship between diabetes (and impaired insulin signaling) and neurodegenerative diseases, as well as the possible benefit of antidiabetic treatments as neuroprotectors, even in non-diabetic patients.', "We review the existing epidemiological, experimental and clinical evidence that supports the interplay between insulin and neurodegeneration in Parkinson's disease, as well as the role of antidiabetic treatments in this disease."], ['AD is a neurodegenerative disease, and its frequency is often reported to be higher for women than men: almost two-thirds of patients with AD are women.'], ["Introduction: Alzheimer's disease (AD) is the most common neurodegenerative disorder and the primary form of dementia in the elderly."], ['Progression of cognitive decline with or without neurodegeneration varies among elderly subjects.'], ["Additionally, in elderly, PE might represent a remarkable tool reducing cognitive impairments related to the normal aging processes and it has also been found to have an impact in neurodegenerative diseases such as Alzheimer's disease."], ['This article summarizes our recent studies showing that astrocyte senescence plays a critical role in neurodegenerative diseases and integrates extracellular tau into the regulatory loop of senescent astrocyte-mediated neurotoxicity.', 'Human astrocytes in vitro undergoing senescence were shown to acquire the inflammatory senescence-associated secretory phenotype (SASP) and toxicity to neurons, which may recapitulate aging- and disease-associated neurodegeneration.', 'These findings suggest that senescent astrocytes induced by various conditions and insults, including tau exposure, may represent a therapeutic target to inhibit or delay the progression of neurodegenerative diseases.', 'We also discuss the pathological activity of extracellular tau in microglia and astrocytes, the disease relevance and diversity of tau forms, therapeutics targeting senescence in neurodegeneration, and the roles of p53 and its isoforms in astrocyte-mediated neurotoxicity and neuroprotection.'], ['Also, activin/TGFbeta signal through type II and type I receptors, both of which are transmembrane serine/threonine kinases, and the serine/threonine phosphorylation of APs, including Abeta42 serine 8 and alphaS serine 129, may confer pathological significance in neurodegenerative diseases.'], ['Some trace elements (TE) are eminently toxic for humans (e.g., Al, Pb, Hg, Cd) and its presence in the central nervous system has been linked to the etiology of neurodegenerative diseases (ND).', 'More recently, the focus has shifted to the potential role of the imbalances on essential TE levels (e.g., Fe, Cu, Zn, Se) within the brain tissue, and they have also been identified as potentially responsible for the cognitive decline associated with normal ageing and the development of some ND, although their definite role remains unclear.', 'Moreover, since the brain is a highly heterogeneous organ, with anatomically and physiologically very different areas, a detailed mapping of TE distribution across the brain tissue of normal individuals, with an in-depth analysis of TE levels in the different brain regions, is a mandatory prior work so that the results obtained from patients suffering from ND and other brain diseases can be interpreted.'], ['Unless the myelin sheath is repaired, these insults will lead to neurodegeneration.', "Thus, pharmacological intervention that promotes CNS remyelination could have a major impact on patient's lives by delaying or even preventing neurodegeneration."], ["Parkinson's disease (PD) is a heterogeneous neurodegenerative disease characterized by the progressive loss of dopaminergic neurons in the substantia nigra pars compacta and the widespread occurrence of proteinaceous inclusions known as Lewy bodies and Lewy neurites."], ['Neuroinflammation and abnormal mitochondrial function are related to the cause of aging, neurodegeneration, and neurotrauma.'], ['The present review analyzes the neuroprotective role of DHA and AA in the extreme stages of life, emphasizing the importance of these LCPUFA during the first year of life and in the developing/prevention of neurodegenerative diseases associated with aging.'], ['The aberrant expression of HDAC2 and subsequent dysregulation of neuronal gene expression is implicated in neurodegeneration and brain aging.', 'Human induced pluripotent stem cell-derived neurons (hiPSC-Ns) are widely used models for studying neurodegenerative disease mechanisms, but the role of HDAC2 in hiPSC-N differentiation and maturation has not been explored.'], ['Since NLRP3 inflammasome plays a pivotal role in several neurodegenerative disorders, we hypothesized that levels of inflammasome components could help in diagnosis or prognosis of amyotrophic lateral sclerosis (ALS).'], ['They had no increased risk to develop pulmonary conditions, cancer, or neurological conditions.'], ['The increase in life expectancy and the migration of individuals with Chagas disease (ChD) from rural to urban centers exposes them to the development of chronic-degenerative abnormalities that may increase the prevalence of metabolic syndrome (MetS).'], ['Neurodegenerative diseases (ND), as a group of central nervous system (CNS) disorders, are among the most prominent medical problems of the 21st century.', 'ND imposes a psychologic, economic and social burden on the patients and their families.', 'Currently, there is no effective treatment for ND.', 'Since many ND result from the gain of function of a mutant allele, small interference RNA (siRNA) can be a potential therapeutic agent for ND management.', 'Since there are some issues related to siRNA delivery routes, in this review, we focus on the application of siRNA in the management of ND treatment from 2000 to 2020.'], ['If improperly repaired, DSBs can threaten genome integrity and contribute to premature ageing, neurodegenerative disorders and carcinogenesis.'], ["BACKGROUND: Lewy body dementia (LBD), consisting of dementia with Lewy bodies (DLB) and Parkinson's disease dementia (PDD), is the second most common type of neurodegenerative dementia in older people."], ['Taken together, we showed that the dosage of neuronal NELF-A affects multiple aspects of aging in Drosophila by regulating transcription of Hsp genes in the brains, suggesting that targeting transcription elongation might be a viable therapeutic strategy against age-onset diseases like neurodegeneration.'], ['It is a fatal neurodegenerative condition caused by prions that mainly affects elderly patients.'], ['INTRODUCTION: Coronavirus Disease 2019 (COVID-19) poses a substantial threat to the lives of the elderly, especially those with neurodegenerative diseases, and vaccination against viral infections is recognized as an effective measure to reduce mortality.', 'However, elderly patients with neurodegenerative diseases often suffer from abnormal immune function and take multiple medications, which may complicate the role of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines.', 'Currently, there is no expert consensus on whether SARS-CoV-2 vaccines are suitable for patients with neurodegenerative diseases.', 'AREAS COVERED: We searched Pubmed to conduct a systematic review of published studies, case reports, reviews, meta-analyses, and expert guidelines on the impact of SARS-CoV-2 on neurodegenerative diseases and the latest developments in COVID-19 vaccines.', 'We also summarized the interaction between vaccines and age-related neurodegenerative diseases.', 'The compatibility of future SARS-CoV-2 vaccines with neurodegenerative diseases is discussed.', 'The pathogenesis and treatment of neurodegenerative diseases is complex, and these diseases often involve abnormal immune function, which can substantially affect the safety and effectiveness of vaccines.', 'In short, this article provides recommendations for the use of vaccine candidates in patients with neurodegenerative diseases.'], ['We recently demonstrated that brain ischemia triggers an age-dependent deregulation of TDP-43 that was associated with exacerbated neurodegeneration.'], ['We describe how new technologies and large-scale international collaborations are helping to disentangle the effect of genetic and environmental risk factors on brain aging and neurodegenerative diseases.'], ['Ginkgolide B (GB), a small natural molecule from Ginkgo biloba, has been reported to possess pharmacological activities by regulating reactive oxygen species (ROS) in aging-related degenerative diseases.'], ["BACKGROUND: To investigate the association of plasma pTau181, assessed with a new immunoassay, with neurodegeneration of white matter and gray matter cross-sectionally and longitudinally, in aging and Alzheimer's disease.", 'Linear regressions and linear mixed-effect models were used to test the cross-sectional and longitudinal associations between baseline plasma pTau181 and neurodegeneration using voxel-based morphometry.', 'Finally, in cognitively impaired individuals, plasma pTau181 concentrations were negatively correlated with both gray and white matter volume as early as 12 months after baseline, and neurodegeneration increased in an incremental manner until 48 months.', "CONCLUSIONS: Higher levels of plasma pTau181 correlate with neurodegeneration and predict further brain atrophy in aging and Alzheimer's disease.", 'Plasma pTau181 may be useful in predicting AD-related neurodegeneration, comparable to positron emission tomography or cerebrospinal fluid assessment with high specificity for AD neurodegeneration.'], ['Importantly, SARS-CoV-2 triggers de novo type 2 diabetes mellitus (T2DM) linked to age-associated cardiovascular disease (CVD), cancers, and neurodegeneration.'], ['Neurodegeneration in the central nervous system (CNS) is a defining feature of organismal aging that is influenced by peripheral tissues.'], ['Examples reviewed herein include omega-3 fatty acids and dietary fiber for the prevention of CVD, alpha-tocopherol (vitamin E) for the treatment of biopsy-proven nonalcoholic steatohepatitis, vitamin D for the prevention of neurodegenerative diseases, thiamine and alpha-lipoic acid for the treatment of diabetic neuropathy, and the role of folate in cancer epigenetics.'], ['BACKGROUND: People with neurodegenerative disorders show diverse clinical syndromes, genetic heterogeneity, and distinct brain pathological changes, but studies report overlap between these features.', 'Predicted immune cell-type proportions are disrupted across all neurodegenerative disorders.', 'CONCLUSIONS: We identify shared differentially methylated positions in whole blood between neurodegenerative disorders that point to shared pathogenic mechanisms.'], ['The nomenclature and radiological phenotypes of CSVD were published in 2013 based on the unified position of the so-called Centres of Excellence in Neurodegeneration.'], ['Understanding the dynamics of brain networks by applying the entropy parameter could be useful for developing appropriate and personalized rehabilitation programs and for future studies on neurodegenerative diseases.'], ['It could be explained by a shift in balance between direct effects (increased dopamine synthesis) and indirect effects (neurodegeneration and chronic inflammation, which can decrease dopamine levels).'], ['The retina, as the only visually accessible tissue in the central nervous system, has attracted significant attention for evaluating it as a biomarker for neurodegenerative diseases.', 'Our data provide compelling evidence that abnormal tau accumulation can lead to pathology in the retinal NVU, and vascular alterations occur more manifest and earlier than neurodegeneration in the retina.', 'These data suggest that retinal NVU may serve as a potential biomarker for diagnosis and staging of tauopathy as well as a platform to study the molecular mechanisms of neurodegeneration.'], ['BACKGROUND: Mitochondrial dysfunction is a common feature of aging, neurodegeneration, and metabolic diseases.'], ["Idiopathic Parkinson's Disease (iPD) is a common motor neurodegenerative disorder.", 'Furthermore, the greatest challenge is to distinguish iPD from other similar neurodegenerative disorders, "atypical parkinsonisms", such as Multisystem Atrophy, Progressive Supranuclear Palsy and Cortical Basal Degeneration, since they share many phenotypic manifestations, especially in the early stages.', 'The diagnosis of these neurodegenerative motor disorders is essentially clinical.'], ['METHODS: We studied autopsied subjects in the Arizona Study of Aging and Neurodegenerative Disorders who had antemortem olfactory testing and a neuropathological diagnosis of either PD, PSP, or control.'], ['However, ageing remains one of the critical risk factors in contributing to major incapacitating and fatal conditions, including cancer and neurodegeneration.'], ['PD is a progressive neurodegenerative disease affecting more than six million people worldwide.'], ['Defects in telomere integrity result in cell dysfunction and the development of diseases, including neurodegenerative disorders, cancer and premature aging syndromes, among others.'], ['While direct molecular hallmarks of the C9orf72 HRE (repeat RNA foci, dipeptide repeat protein pathology) are well characterized, the mechanisms by which the C9orf72 HRE causes ALS and the related neurodegenerative disease frontotemporal dementia (FTD) remain poorly understood.'], ["Alzheimer's disease (AD) is the most frequent neurodegenerative disorder that commonly causes dementia in the elderly."], ['There is also growing evidence that mTBI is a potential risk factor for accelerated cognitive decline and neurodegeneration.'], ['NR treatment also prevents neurodegeneration, suppresses senescence and neuroinflammation, and improves motor function in Atm-/- mice.'], ['BACKGROUND: Early detection of anxiety symptoms in older people is capital as it may be linked to increased physical/functional disabilities, onset and progression of neurodegenerative disorders, and poor cognitive functioning.'], ['OBJECTIVE: To report the clinical, AV-133 PET, AV-45 PET, and neuropathological findings of three clinically diagnosed dementia patients who were part of the Avid Radiopharmaceuticals AV133-B03 study as well as the Arizona Study of Aging and Neurodegenerative Disorders (AZSAND).'], ['In this paper, we are going to review relevant studies discussing the association between important modifiable factors, known as CR proxies (i.e., educational attainment, occupational complexity, physical activity, social engagement, bilingualism, leisure activities, and Mediterranean diet), and different domains of cognitive function, which are affected either in the process of healthy aging or neurodegenerative diseases.'], ['Moderate to large scale studies have now been conducted in the target tissue of neurodegenerative diseases, the brain, and, through the use of rigorous statistical methodologies, have laid a foundation of validated observations and successful study designs that inform our perspective on the role of the epigenome in these diseases, generate new hypotheses, and guide our path forward for a second generation of studies.', "Thus, the epigenome may be involved at multiple different stages of the sequence of events that leads to human neurodegeneration, and we review the study designs that may begin to guide the development of a more comprehensive perspective on the aging brain's epigenome."], ["Circulating melatonin levels are consistently reduced in the metabolic syndrome, ischemic and non-ischemic cardiovascular diseases and neurodegenerative disorders like the Alzheimer's and Parkinson's diseases."], ['This may reflect a damaging but small impact of HI; explained in part by smaller BV and different microstructure pathways but not via pathology related to AD (amyloid, hippocampal volume, AD cortical thickness) or ongoing neurodegeneration (serum NFL).'], ["The loss of these complementary redox effects may augment oxidative stress during ageing in dopamine-producing cells of mutant PRKN allele carriers, thereby enhancing the risk of Parkinson's-linked neurodegeneration."], ['Brain-specific SIRT6-KO mice present increased DNA damage, learning impairments, and neurodegenerative phenotypes, placing SIRT6 as a key protein in preventing neurodegeneration.'], ['Abdominal aortic aneurysm (AAA) is a chronic inflammatory degenerative aortic disease, which particularly affects older people.'], ['There is a growing evidence that pre-clinical stage of many neurodegenerative diseases involves changes in interactions between astrocytes and neurons.', 'Still, the efficiency of astrocyte-targeting compounds in preventing age-related cognitive decline is yet to be fully explored, in particular in the animal models of neurodegenerative diseases and autophagy impairment.'], ["Background and Objectives: Neurodegenerative diseases that typically affect the elderly such as Alzheimer's disease, Parkinson's disease and frontotemporal dementia are typically characterised by significant cognitive impairment that worsens significantly over time.", 'Materials and Methods: We conducted an in-depth literature review of the state-of-the-art of the contribution of these techniques across these neurodegenerative diseases.', 'Conclusions: Further and more robust studies should evaluate the potentialities and limitations of the application of these promising therapeutic tools to neurodegenerative diseases.'], ['However, an imbalance in brain iron homeostasis caused by aging underlies many neurodegenerative diseases.'], ['The objective of this review is to analyse the effectiveness of EOs as neuroprotective remedies among the four common age-related neurodegenerative diseases.', 'Our review provided useful evidence on EOs as potential neuroprotective remedies for age-related neurodegenerative diseases.'], ['The effects of famine were widespread and affected the structure and function of many organs and tissues, resulted in altered behaviour and increased risks of chronic degenerative diseases and increased mortality.'], ['Additionally, there is limited data published about early psychiatric manifestations of neurodegenerative disorders in the elderly.'], ['Results indicated that CP is particularly vulnerable to aging and neurodegeneration.', 'These data suggest that the decline in CP with age is further impacted by accelerated aging and neurodegeneration, providing insights for improving intervention strategies.'], ['METHODS: To analyze the effect of vascular injuries independently of other pathological conditions, we studied a population-based cohort of nondemented older adults, after the exclusion of people who were diagnosed with neurodegenerative diseases during the 14-year clinical follow-up period.', 'CONCLUSIONS: These cross-sectional and longitudinal findings highlight the links between vascular brain injuries and a differential vulnerability of the subiculum within the hippocampal loop, unbiased of the effect of neurodegenerative diseases, and particularly when vascular injuries affect deep/subcortical structures.'], ['BACKGROUND: Ageing, depression, and neurodegenerative disease are common risk factors for delirium in the elderly.'], ["Neurodegenerative disorders are a diversity of disorders, surrounding Alzheimer's (AD), Parkinson's (PD), Huntington's diseases (HD), and amyotrophic lateral sclerosis (ALS) accompanied by some other less common diseases generally characterized by either developed deterioration of central or peripheral nervous system structurally or functionally.", 'Today, with the viewpoint of an increasingly aging society, the number of patients with neurodegenerative diseases and sociomedical burdens will spread intensely.', 'During the last decade, stem cell technology has attracted great attention for treating neurodegenerative diseases worldwide because of its unique attributes.', 'In the present review, we provide a summary of the therapeutic potential of stem cells and discuss the current status and prospect of stem cell strategy in neurodegenerative diseases, in particular, AD, PD, ALS, and HD.'], ["Together, these results provide novel insights into how human aging affects computations in the brain's navigation system, highlighting the critical role of the hippocampus.SIGNIFICANCE STATEMENT Key structures of the brain's navigation circuit are particularly vulnerable to the deleterious consequences of aging, and declines in spatial navigation are among the earliest indicators for a progression from healthy aging to neurodegenerative diseases."], ["BACKGROUND: Alzheimer's disease (AD) is a chronic, neurodegenerative disease resulting in a progressive decline of autobiographical memories (AMs) which favors the development of psycho-behavioral disorders."], ['Objective: Amyotrophic Lateral Sclerosis (ALS) is a heterogeneous neurodegenerative disorder with a median survival of 3 years.'], ['High-throughput screenings in C. elegans have indeed contributed to the breakthrough of a wide variety of candidate compounds involved in extensive fields including neurodegeneration, pathogen infections and metabolic disorders.', 'As illustrative examples, we discuss the utility of C. elegans models of both human neurodegenerative diseases and parasitic nematodes in the drug discovery industry.'], ['We identified three multimorbidity patterns: musculoskeletal, cardio-metabolic, and mental-degenerative diseases.', 'The mental-degenerative disease pattern was associated with BADL disability (OR 1.55, 95%CI 1.40-1.72).'], ['MSCs undergo aging in response to various stresses, and this causes many diseases including degenerative disorders.'], ['However, studies in rodent models of AD and other neurodegenerative diseases raise the possibility that targeting neurogenesis may ameliorate cognitive dysfunction in AD.'], ["Parkinson's Disease (PD) is a common neurodegenerative disease which impacts millions of people around the world."], ['Neurodegenerative diseases (NDs) are incurable and can develop progressively debilitating disorders, including dementia and ataxias.', "Alzheimer's disease and Parkinson's disease are the most common NDs that mainly affect the elderly people.", 'The abnormal changes in glycosylation are associated with the altered biological pathways in NDs.', 'Importantly, specific glycosylation changes in cerebrospinal fluid, blood and urine are valuable for revealing neurodegeneration in the early stages.', 'This review describes the emerging biomarkers based on glycoproteomics in NDs, highlighting the potential applications of glycoprotein biomarkers in the early detection of diseases, monitoring of the disease progression, and measurement of the therapeutic responses.'], ["Parkinson's disease (PD) is the second more common neurodegenerative disease with increasing incidence worldwide associated to the population ageing."], ["BACKGROUND: Parkinson's disease is a progressive neurodegenerative disease and the second most common neurological disease in the world, which usually affects people mainly in later years of life."], ['BACKGROUND: Longitudinal magnetic resonance imaging (MRI) studies have become increasingly important to assess the changes in brain morphology during normal aging and neurodegenerative disorders.'], ['Initially, SWI and related sequences were mostly used to improve the depiction of findings already known from standard two-dimensional T2*-weighted neuroimaging: more microbleeds in patients who are aging or with dementia or mild brain trauma; increased conspicuity of superficial siderosis in Alzheimer disease and amyloid angiopathy; and iron deposition in neurodegenerative diseases or abnormal vascular structures, such as capillary telangiectasia.'], ['Breakdowns and dysfunction of the glymphatic system and meningeal lymphatics play a crucial role in age-related brain changes, the pathogenesis of neurovascular and neurodegenerative diseases, as well as in brain injuries and tumors.', 'A new understanding of how aging, medications, sleep and wake cycles, genetic predisposition, and even body posture affect the brain drainage system has not only changed the idea of brain fluid circulation but has also contributed to an understanding of the pathology and mechanisms of neurodegenerative diseases.'], ['In this article, we detail how progress in brain MRE technology has provided unique insights into healthy brain aging, neurodegeneration, and structure-function relationships.', 'We further discuss additional promising technical innovations that will enhance the specificity and sensitivity for brain MRE to reveal considerably more about brain aging as well as its potentially valuable role as an imaging biomarker of neurodegeneration.'], ['Our increasingly aging society leads to a growing incidence of neurodegenerative diseases.', 'Cell-based additive gene therapies for the increased expression of a protective factor are considered as a promising option to medicate neurodegenerative diseases, such as age-related macular degeneration (AMD).'], ["Melatonin (MLT) is a neurohormone that is regulated by the circadian clock and plays multifunctional roles in numerous neurodegenerative disorders, such as Alzheimer's disease (AD)."], ["Parkinson's disease (PD) is a neurodegenerative disorder linked with aging and primarily involves dopaminergic neuronal loss in the substantia nigra pars compacta (SNpc)."], ['For this reason, NAD+ is often studied in the context of aging, cancer, and neurodegenerative and metabolic disorders.', 'MAJOR CONCLUSIONS: An alteration in the NAD+/NADH ratio or the NAD+ pool size can lead to derailment of the biological system and contribute to various neurodegenerative disorders, aging, and tumorigenesis.'], ['Dysregulation of those processes is likely to increase the risk in multiple aspects of aging-related diseases, including cancers, neurodegenerative disorders, chronic kidney diseases, bone dysplasia and pulmonary fibrosis.'], ["In this review, we focus on some of the dominant paradigms of pathological aging, such as amyotrophic lateral sclerosis (ALS), Alzheimer's disease (AD), and Parkinson's disease (PD), and predict that the antioxidant superoxide dismutase 1 (SOD1), when post-translationally modified by aging-associated oxidative stress, acts as a mechanism to accelerated aging in these age-related neurodegenerative diseases."], ['Clinical data reveal an early impairment of olfaction during normal aging and in the course of neurodegenerative diseases, but the underlying cellular/molecular mechanisms remain obscure.'], ['We conducted a data-driven exploration of distinct AD neurodegeneration subtypes using FDG-PET as a sensitive molecular imaging marker of neurodegenerative processes.', 'CONCLUSIONS: These findings complement recent research efforts on MRI-based identification of distinct AD atrophy subtypes and may provide a potentially more sensitive molecular imaging tool for early detection and characterization of AD-related neurodegeneration variants at prodromal disease stages.'], ['Aging is an important stage of the human life cycle and the primary risk factor for Neurodegenerative Diseases (ND).', 'The new therapies for ND are restricted as they are primarily targeted at final disease progression, including behavioral shifts, neurological disorders, proteinopathies and neuronal failure.', 'Therefore, this approach represents a prophylactic way to target risk factors that rely on their action against ND that does not occur through current pharmacological agents over the life of a person.'], ["Alzheimer's disease is a devastating neurodegenerative disease with a dramatically increasing prevalence and no disease-modifying treatment."], ['It has been shown to be a sensitive and specific biomarker of neurodevelopment and neurodegeneration.'], ['These changes are more evident in older persons with neurodegenerative diseases and cognitive-motoric frailty.', 'They determine the acceleration of neurodegenerative diseases with cognitive and motoric frailty.', 'SUMMARY: The interaction between liver and gut microbiota may accelerate the neurodegenerative diseases and represents a promising marker of prognostic trajectories in older patients.'], ['Immunosenescence contributes to cognitive impairment and neurodegeneration, and those conditions could be attenuated by non-pharmacological anti-inflammatory strategies, such as exercise and supplementation with the amino acid taurine.'], ['CONCLUSIONS: The association between NfL serum levels and brain atrophy and neuropsychological performance in individuals without overt neurological disease is similar to that seen in patients with neurodegenerative diseases.'], ['Numerous studies have shown that SHP2 plays important roles in the regulation of inflammatory diseases, including cancer-related inflammation, neurodegenerative diseases and metabolic diseases.'], ["INTRODUCTION: The locus coeruleus (LC) undergoes extensive neurodegeneration in early Alzheimer's disease (AD)."], ['However, there is a strong connection between DNA repair and neuronal metabolism, mediated by nucleotide salvaging and the poly ADP-ribose (PAR) response, and this connection has been implicated in other age-onset neurodegenerative diseases.'], ["Mitochondrial dysfunction is an established hallmark of aging and neurodegenerative disorders such as Down syndrome (DS) and Alzheimer's disease (AD)."], ['Aging, obesity and type 2 diabetes mellitus are associated with perfusion abnormalities leading to cognitive impairment, neurodegeneration and future development of dementia.'], ['Encouragingly, engaging in EE has been shown to lead to neural improvements, suggesting it is a promising avenue for offsetting hippocampal neurodegeneration in m-sTBI.'], ['Diseases with a significant loss of neurons, structurally and functionally are termed as neurodegenerative diseases.', 'Neurodegenerative diseases are generally caused by depletion of proteins, oxidative and inflammatory stress, environmental changes and so on, with aging being the most important cause.', 'Natural compounds can be used in order to treat neurodegenerative diseases Medicinal plants such as Ginseng, Withania somnifera, Bacopa monnieri, Ginkgo biloba, etc.', 'This review deals with the use of different medicinal plants for the prevention of neurodegenerative diseases.'], ['Systemic infection is an important risk factor for the development cognitive impairment and neurodegeneration in older people.'], ["Alzheimer's disease (AD) is the most common neurodegenerative disease among the elderly."], ["BACKGROUND: Alzheimer's Disease (AD) is a neurodegenerative brain disease in the elderly."], ['BACKGROUND: Due to an ageing demographic and rapid increase of cognitive impairment and dementia, combined with potential disease-modifying drugs and other interventions in the pipeline, there is a need for the development of accurate, accessible and efficient cognitive screening instruments, focused on early-stage detection of neurodegenerative disorders.', 'All patients were assessed for presence of neurodegenerative disorder in accordance with standard investigative procedures.'], ['However, as a neurodegenerative disorder with systemic inflammation, the periphery organs may also play a key role in AD pathology.'], ['However, evidence of an effect on neurodegeneration, which may require longer follow-up period to observe, is more limited.', 'Leveraging biomarkers from a large population-based cohort study of older adults, we investigated whether blood carotenoids were associated with atrophy of the medial temporal lobe (a biomarker of neurodegeneration in aging) over 10 years.', 'CONCLUSIONS: Our results based on a unique long-term prospective evaluation of a neuroimaging biomarker suggest a beneficial role of carotenoids for the prevention of age-related neurodegeneration.'], ['BACKGROUND: Bilateral decompression via unilateral approach (BDUA) is an effective surgical approach for treating lumbar degenerative diseases.'], ["Alzheimer's disease (AD) is a lethal neurodegenerative disorder primarily affecting the aged population.", 'On this basis, we further speculated the roles of TREM2 in different stages of AD, which may shed light to the development of TREM2-targeted strategy for the prevention and treatment of this neurodegenerative disorder.'], ['BACKGROUND: Adult-onset neurodegenerative diseases affect millions and negatively impact health care systems worldwide.', 'Evidence suggests that air pollution may contribute to aggravation of neurodegeneration, but studies have been limited.'], ['BACKGROUND: Age-related macular degeneration (AMD) is a progressive, multifactorial, degenerative disease and the leading cause of severe visual loss in the elderly population.'], ['AD is described as a neurodegenerative disease that gradually compromises memory and learning capacity.'], ["Increased life expectancies have significantly increased the number of individuals suffering from geriatric neurodegenerative diseases such as Alzheimer's disease (AD) and Parkinson's disease (PD).", 'Unfortunately, most recent high-profile clinical trials for neurodegenerative diseases have failed to obtain efficacious results, indicating that novel approaches are desperately needed to treat these pathologies.', 'Furthermore, multiple cell types in the senescent state in the brain, including neurons, microglia, astrocytes, and neural stem cells, have recently been observed in the context of neurodegenerative diseases, suggesting that these senescent cells may play an essential role in the pathological processes of neurodegenerative diseases.', 'Therefore, this review begins by outlining key aspects of cell senescence constitution followed by examining the evidence implicating senescent cells in neurodegenerative diseases.', 'In the final section, we review how cell senescence may be targeted as novel therapeutics to treat pathologies associated with neurodegenerative diseases.'], ['We then analyzed expression of genes in this core sensome in five different datasets from two neurodegenerative disease models at various stages of the diseases and found that, overall, changes in the level of expression of microglial sensome genes are specific to the disease or condition studied.'], ['Here, we review the interplay between vascular and cognitive dysfunctions associated with aging, to disentangle the complex mechanisms underpinning the development and progression of neurodegenerative disorders, with a specific focus on AD.'], ["Nowadays, life expectancy has increased, as a result, neurodegenerative diseases such as Parkinson's and Alzheimer's disease have started to occur more frequently."], ['New models in which aging-related neurodegeneration more closely resembling the combination of pathologies that develop in aging humans, are needed.', 'Furthermore, existing data pertaining to neurodegeneration in these fish is discussed in the context of their reported neuropathologies, along with open questions related to mammalian chronopathologies.', 'Neurogenesis and age-related changes therein are discussed in the context of siRNA and neurodegeneration.', 'Finally, research focus areas are highlighted, and a case is made for the utility of these fish in the study of aging-related neurodegeneration, and to screen for environmental risk factors of aging-related neuropathology.'], ['This leads us to propose that concurrent DSBs and induction of inflammation occurring throughout life may be the underlying cause of ageing, degenerative disorders, and cancer.'], ['Successful segmentation of the total intracranial vault (ICV) and ventricles is of critical importance when studying neurodegeneration through neuroimaging.', 'The pipeline and models are available at: https://icvmapp3r.readthedocs.io and https://ventmapp3r.readthedocs.io to enable further investigation of the roles of ICV and ventricles in relation to normal aging and neurodegeneration in large multi-site studies.'], ['alpha-Klotho is known for its aging-related functions and is associated with neurodegenerative diseases, accelerated aging, premature morbidity, and mortality.'], ["The worldwide increase in the number of patients with dementia is becoming a growing problem, while Alzheimer's disease (AD), a primary neurodegenerative disorder, accounts for more than 70% of all dementia cases."], ["Alzheimer's disease (AD) is the most common neurodegenerative disease among the elderly and has become a growing global health problem causing great concern."], ["BACKGROUND: Aging is associated with most neurodegenerative disorders such as Parkinson's and Alzheimer's diseases.", 'OBJECTIVE: This study addresses a cross-sectional analysis to identify changes in lipid, minerals, and antioxidant capacity as potential biomarkers to the onset of neurodegenerative diseases during aging.'], ['Aging is a driving factor of various age-related diseases, including neurodegenerative diseases, cardiovascular diseases, cancer, immune system disorders, and musculoskeletal disorders.'], ['Brain iron overload has been shown in various neurodegenerative disorders and in normal aging.'], ['Here we report the synthesis of kinetin isosteres with the purine ring replaced by other bicyclic heterocycles, and the biological evaluation of their activity in several in vitro models related to neurodegenerative diseases.'], ["Accumulating transcriptomic studies of aging brains show the splicing disruption is a widespread hallmark of neurodegenerative diseases such as Alzheimer's disease (AD).", 'ExonSkipAD will be a unique resource of transcriptomic diversity research for understanding the mechanisms of neurodegenerative disease development and identifying potential therapeutic targets in AD.'], ['The study included 101 female patients aged 60 years or older scheduled to undergo surgery for degenerative lower extremity diseases.'], ['Besides acting as an intracellular receptor for cyclosporine A, CypA plays a vital role in microorganismal infections, cardiovascular diseases, liver diseases, kidney diseases, neurodegeneration, cancer, rheumatoid arthritis, periodontitis, sepsis, asthma, and aging.'], ['These results corroborate recent findings that argue for an additional downstream role for iron as an effector of neurodegeneration, acting independently of tau or amyloid pathologies.', 'We hypothesize that the level of tissue iron is a trait that dictates the probability of neurodegeneration in AD by ferroptosis, a regulated cell death pathway that is initiated by signals such as glutathione depletion and lipid peroxidation.'], ['The intracranial glymphatic system is the internal environment that maintains brain survival and metabolism, and thus fluid exchange changes in the glymphatic system under various pathological conditions can provide important insights into the pathogenesis and differential diagnosis of many neurodegenerative diseases such as iNPH.'], ['This review covers clinical studies as well as investigations in animal models and will further highlight the emerging link between insulin resistance and neurodegenerative disorders.'], ["BACKGROUND: Myelin loss is a central feature of several neurodegenerative diseases, including Alzheimer's disease (AD)."], ['Finally, CSF inflammatory changes were highly correlated with amyloid, tau, general neurodegeneration, and cognition, while plasma changes were mostly associated with amyloid and cognition.'], ['This article reviews the current literature to identify where Orthopaedic Nurse Practitioners (ONPs) currently fill gaps in care delivery through varied scopes of practice in musculoskeletal trauma, degenerative disease, tumour and bone health.'], ['Motor exercise, such as sport or musical activities, helps with a plethora of diseases by modulating brain functions in neocortical and subcortical regions, resulting in behavioural changes related to mood regulation, well-being, memory, and even cognitive preservation in aging and neurodegenerative diseases.'], ["BACKGROUND: Alzheimer's disease (AD) is the most common neurodegenerative disease characterized by progressive memory loss and cognitive impairment."], ['However, in different pathological conditions, this process is impaired in neuronal cells and lead to a variety of neurodegenerative disease (NDD).', 'We have also elaborated upon various novel therapeutic strategies and their limitations to enhance mitophagy in NDDs that may help in the management of symptoms and increasing the life expectancy of NDD patients.'], ["Advances in molecular positron emission tomography (PET) have enabled anatomic tracking of brain pathology in longitudinal studies of normal aging and dementia, including assessment of the central model of Alzheimer's disease (AD) pathogenesis, according to which TAU pathology begins focally but expands catastrophically under the influence of amyloid-beta (Abeta) pathology to mediate neurodegeneration and cognitive decline."], ['To investigate further, the WTCHP convened a scientific workshop that examined the natural history of cognitive aging and impairment, biomarkers in the pathway of neurodegenerative diseases, the neuropathological changes associated with hazardous exposures, and the evidence of cognitive decline and impairment in the 9/11-exposed population.'], ['The loss of proteostasis over the life course is associated with a wide range of debilitating degenerative diseases and is a central hallmark of human aging.', 'This Review will report on each of these techniques and their successes and shortcomings in an attempt to standardize comparisons between protein oligomers across disciplines, especially in the context of neurodegeneration.'], ['Meanwhile, these findings highlight the importance to better understand TMEM106B function and dysfunction in the context of normal aging and neurodegenerative diseases.'], ['Age-related neurodegenerative diseases are a growing burden to society, and many are sporadic, meaning that the environment, diet and lifestyle play significant roles.', 'Cerebrospinal fluid (CSF)-mediated clearing of brain waste products via perivascular pathways, named the glymphatic system, is receiving increasing interest, as it offers unexplored perspectives on understanding neurodegenerative diseases.', 'The glymphatic system is involved in clearance of metabolic by-products such as amyloid-beta from the brain, and its function is believed to lower the risk of developing some of the most common neurodegenerative diseases.'], ['Caregivers of elderly people with neurodegenerative diseases are highly vulnerable to stressful situations and mood disorders due to their work conditions.', 'This study investigated indexes of stress and depression symptoms in caregivers of the elderly with neurodegenerative diseases, their caffeine intake and the association between stress and depressive symptoms with the salivary biomarkers cortisol, nitric oxide and DNA damage.'], ['This study builds a foundation for future investigations of neurocognitive disorders and neurodegenerative diseases in the oldest old, including centenarians.'], ["BACKGROUND: Quantitative assessment of CBFGM may provide an imaging biomarker for the early detection of those at risk of neurodegenerative diseases, such as Alzheimer's and dementia."], ['Osteoarthritis is the most prevalent joint degenerative disease and has been considered a major cause of severe joint pain and physical disability in the elderly.'], ["Aging is a main risk factor for neurodegenerative disorders including Alzheimer's disease."], ['Defects in mitophagy are associated with various pathological conditions such as neurodegeneration, heart failure, cancer, and aging, further underscoring the biological relevance.'], ["OBJECTIVES: Neurodegenerative diseases (NDs), such as Parkinson's disease and Alzheimer's disease and related dementias, are a leading cause of death and disability in China.", 'Although studies have demonstrated that depression is associated with NDs, little is known about the factors impacting this relationship.', 'This study aimed to explore and identify the risk and protective factors of depression among Chinese older adults with NDs.', 'Among the sample, 334 older adults aged 65 and older with NDs were included in the analysis.', 'CONCLUSION: Our findings suggest that policymakers and healthcare professionals should pay specific attention to the regional disparities of healthcare services and the cultural background to understand the relationship between NDs and depression and improve the well-being of ND patients.'], ['Magnetic sensing of the human brain provides compelling evidence of new electric mechanisms in human brains and may interfere with the evolution of neurodegenerative diseases.'], ['Internal manifestations of premature aging, including peripheral neuropathy, progressive sensorineural hearing loss, and neurodegeneration, are reported in 25% of patients with XP.'], ['Given the tremendous amount of evidence linking neuroinflammation with neural dysfunction, it is no surprise that the Western diet has been implicated in the development of many diseases and disorders of the brain, including memory impairments, neurodegenerative disorders, and depression.'], ['The Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) study is a 3-year, multicenter, randomized controlled trial to test the effects of the MIND diet on cognitive function in 604 individuals at risk for AD.'], ['Cross-linking immunoprecipitation-sequencing data revealed that the RNA-binding proteins bound by most of the deregulated circRNAs include the neurodegeneration-associated FUS, TDP43, FMR1, and ATXN2.'], ["Alzheimer's disease (AD), the most common cause of dementia and neurodegeneration in the elderly, is characterized by deterioration of memory and executive and motor functions."], ['BACKGROUND: Alzheimer disease (AD) is a progressive neurodegenerative disease characterized by impaired memory and cognitive judgment.'], ['OBJECTIVE: The aim of the study was to explore the incidence, severity, mortality rate, clinical features, and risk factors of symptoms of COVID-19 in home-dwelling older people, and its association with type of residence, cognitive deterioration, and neurodegenerative diseases.'], ['Loss of physiological microglial function may increase the propagation of neurodegenerative diseases.', 'Finally, we found strong evidence for iron homeostasis changes in dystrophic microglia, providing a possible molecular mechanism driving the degeneration of microglia in neurodegenerative disease.'], ['Osteoarthritis (OA) is a common chronic degenerative disease that affects the elderly.'], ["Oral ingestion of Pls showed promising health benefits among Alzheimer's disease (AD) patients, suggesting that Pls might have therapeutic potential in other neurodegenerative diseases."], ['Genomic instability caused by a deficiency in the DNA damage response and repair has been linked to age-related cognitive decline and neurodegenerative diseases.', 'Exifone can directly bind to HDAC1 based upon biolayer interferometry assays with kinetic and selectivity profiling, suggesting that HDAC1 is preferentially targeted compared to other class I HDACs and the kinase CDK5, which have also been implicated in neurodegeneration.', 'Taken together, these findings reveal exifone as a potent activator of HDAC1-mediated deacetylation, thereby offering a lead for novel therapeutic development aiming to protect genomic integrity in the context of neurodegeneration and aging.'], ["Interactions among calorie intake, meal frequency, diet quality, and the gut microbiome modulate specific metabolic and molecular pathways that regulate cellular, tissue, and organ homeostasis as well as inflammation during normal brain aging and CNS neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, and multiple sclerosis, among others."], ['Neurons produced by reprogramming of other cell types are used to study cellular mechanisms of age-related neurodegenerative diseases.'], ['Neurodegenerative diseases are characterised by progressive damage to the nervous system including the selective loss of vulnerable populations of neurons leading to motor symptoms and cognitive decline.', "Aging is the primary risk factor of most neurodegenerative diseases including Alzheimer's disease, Parkinson's disease and amyotrophic lateral sclerosis.", 'This review will discuss the current understanding of the role of ubiquitin-dependent processes in the progressive loss of neurons and the emergence of ubiquitin signalling as a target for the development of much needed new drugs to treat neurodegenerative disease.'], ["Disorders of cholesterol metabolism in the brain are linked to neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), and other atypical cognitive deficits that arise at old age.", 'However, the specific role of cholesterol metabolism disorder in the pathogenesis of neurodegenerative diseases has not been fully elucidated.', 'Statins that are a class of lipid-lowering drugs have been reported to have a positive effect on neurodegenerative diseases.', 'Herein, we reviewed the physiological and pathological conditions of cholesterol metabolism and discussed the possible mechanisms of cholesterol metabolism and statin therapy in neurodegenerative diseases.'], ["Alzheimer's disease is a neurodegenerative disorder affecting predominantly the memory of the affected individual."], ['RESULTS: The pandemic associated to COVID-19 has shifted most of the health resources to the emergency area and has consequently left the three main medical areas dealing with the elderly population (oncology, time-dependent diseases and degenerative disease) temporarily "uncovered".'], ['Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) represent two ends of the same disease spectrum of adult-onset neurodegenerative diseases that affect the motor and cognitive functions, respectively.'], ['However, aging is a significant risk factor for neurodegenerative diseases (NDs).', 'Hence, improved life expectancy has led to an increased incidence of NDs.', 'Despite intense research, effective treatments for NDs remain elusive.', 'Recent Advances: As a promising new direction, recent evidence has demonstrated that epigenetic processes modify diverse biochemical pathways, including those related to NDs.', "Here, we review recent advances in elucidating miRNAs' roles in NDs and discuss their potential as therapeutic targets.", 'In particular, neuroinflammation is a major pathological hallmark of NDs and miR146a is a crucial regulator of inflammation.', 'Future Directions: Finally, we explore the possibilities of developing miR146a as a potential biomarker and therapeutic target where additional research may help facilitate the detection and amelioration of neuroinflammation in NDs.'], ["Furthermore, m6A controls protein levels of key genes involved in Alzheimer's disease-associated pathways, suggesting that m6A plays an important role in aging and neurodegenerative disease."], ['As a consequence, cellular processes are affected, which results in the development or progression of several human pathologies, including cancer, diabetes, osteoporosis, and neurodegenerative disorders.'], ['Although microglia in aging and neurodegenerative disease model mice show a loss of homeostatic phenotype and activation of disease-associated microglia (DAM), a correlation between those phenotypes and the degree of neuronal cell loss has not been clarified.', 'Our results implicate a loss of homeostatic microglial function in the progression of AD and other neurodegenerative diseases.'], ['Zn deficiency results in aging, neurodegenerative disease, immune deficiency, abnormal growth, cancer, and other symptoms.'], ['This degradation pathway mediated by CMA plays an important role in regulating glucose and lipid metabolism, transcription, DNA reparation, cell cycle, cellular response to stress and consequently, regulating many aging-associated human diseases, such as neurodegeneration, cancer and metabolic disorders.'], ['Eye movements are studied as biomarkers for pathological changes because they are altered in patients with neurodegenerative disorders.', 'Since the percentage of corrected antisaccade errors was not associated with age but is known to be affected by pathological cognitive decline, it represents a promising candidate preclinical biomarker of neurodegeneration.'], ['The prevalence of neurodegenerative diseases has been significantly increasing in the last decades, and it is expected to continue to grow.'], ['TMEM106B, encoding a lysosome membrane protein, has been recently associated with brain aging, hypomyelinating leukodystrophy and multiple neurodegenerative diseases, such as frontotemporal lobar degeneration (FTLD) and limbic-predominant age-related TDP-43 encephalopathy (LATE).'], ['AIMS: This study, using a surgeon-maintained database, aimed to explore the risk factors for surgery-related complications in patients undergoing primary cervical spine surgery for degenerative diseases.', 'METHODS: We studied 5,015 patients with degenerative cervical diseases who underwent primary cervical spine surgery from 2012 to 2018.'], ['In this study, we have investigated if the lack of CB1r affects noradrenergic neurons in the locus coeruleus (LC), which are vulnerable to age-related changes; their numbers are reduced in patients with neurodegenerative diseases and probably also in healthy aged individuals.'], ["Alzheimer's disease (AD) is one such neurodegenerative disease which mostly affects the elderly population, above the age of 60; marked by cognitive impairment of memory."], ['BACKGROUND AND PURPOSE: Current methods to diagnose neurodegenerative diseases are costly and invasive.', 'CONCLUSIONS: Markers of retinal neurodegeneration are associated with smaller brain volumes.'], ['This discussion is based on a synopsis of 162 published neuroimaging studies (01/2013-12/2019) that applied the FreeSurfer hippocampal subfield segmentation in a broad range of domains including cognition and healthy aging, brain development and neurodegeneration, affective disorders, psychosis, stress regulation, neurotoxicity, epilepsy, inflammatory disease, childhood adversity and posttraumatic stress disorder, and candidate and whole genome (epi-)genetics.'], ['Human induced Pluripotent Stem Cell (hiPSC) models are a valuable new tool for research into neurodegenerative diseases.', 'Neuroinflammation is now recognized as a key process in neurodegenerative disease and aging, and microglia are central players in this.'], ['However, these analyses generally assume static organizational principles, thereby neglecting a fundamental reconfiguration of functional connections in the face of neurodegeneration.', 'Our results shed new light on previous findings obtained by using the graph theory in AD and imply a general principle of the brain in response to neurodegeneration.'], ['With increased longevity and subsequent rise in people with age-related neurodegenerative diseases, protection of neurons from oxidative stress damage has become an important field of study.', 'Therefore, RSP extract can potentially be used/developed as functional food and nutraceuticals in the prevention of many complex neurodegenerative diseases.'], ["Therefore, this review focuses on the role of UPRmt in ageing and ageing-related neurodegenerative diseases such as Alzheimer's disease, Huntington's disease and Parkinson's disease.", 'Considering the pleiotropic actions of UPRmt system, targeting UPRmt pathway may be a potent therapeutic avenue for neurodegenerative diseases, cancers and heart diseases.'], ["CONCLUSIONS: Critical care hospitalization is associated with accelerated brain atrophy in selected brain regions, without increases in amyloid deposition, suggesting a pathogenesis based on neurodegeneration unrelated to Alzheimer''s pathway."], ["Alzheimer's disease (AD) is the most common cause of dementia, typically showing progressive neurodegeneration in aging brains."], ['OBJECTIVE: This study aims to determine whether the sacroiliac (SI) joint motion correlated to pelvic incidence (PI) change from standing to supine position in patients with degenerative spinal diseases.', 'In patients with degenerative diseases, PI was significantly larger on standing position than that on supine position.'], ["Emerging evidence of brain injury on risk of neurodegenerative diseases such as Alzheimer's disease (AD) and chronic traumatic encephalopathy (CTE) have resulted in interest in therapeutic potential of omega-3 fatty acids (n-3FA)."], ['Altered expression of mitochondrial DNA (mtDNA) occurs in ageing and a range of human pathologies (for example, inborn errors of metabolism, neurodegeneration and cancer).'], ['Importance: Parkinson disease (PD) is an increasingly common neurodegenerative disorder in many aging societies.', 'Conclusions and Relevance: In this population-based cohort study, Parkinson disease, a common neurodegenerative disorder common in elderly persons, was independently associated with an increased risk of suicide.'], ['In this comprehensive review, we summarize the critical roles of SIRT6 in the onset and progression of human diseases including cancer, inflammation, diabetes, steatohepatitis, arthritis, cardiovascular diseases, neurodegenerative diseases, viral infections, renal and corneal injuries, as well as the elucidation of the related signaling pathways.'], ['Tau biomarkers may help elucidate the complex relationship between pathology and neurodegeneration in aging.'], ['The progressive accumulation of apoptosis-resistant and secretory active senescent cells (SCs) in animal and human aged tissues may limit lifespan and healthspan and lead to age-related diseases such as cancer, neurodegenerative disorders, and metabolic syndrome.'], ["Aging is a highly complex molecular process, affecting nearly all tissue systems in humans and is the highest risk factor in developing neurodegenerative disorders such as Alzheimer's and Parkinson's disease, cardiovascular disease and Type 2 diabetes mellitus."], ['In patients with established MS, GM involvement and neurodegeneration are associated with accelerated clinical worsening.', 'No qualitative clinical, immunological, histopathological, or neuroimaging features differentiate PPMS and SPMS; both are characterized by imaging findings reflecting neurodegeneration and are also impacted by aging and comorbidities.'], ['In this review, we critically discuss current knowledge of the role of mtDNA copy number regulation in various types of human diseases, including mitochondrial disorders, neurodegenerative disorders and cancer, and during ageing.'], ['PURPOSE OF REVIEW: Locus coeruleus (LC) is the main noradrenergic nucleus of the brain, and its degeneration is considered to be key in the pathogenesis of neurodegenerative diseases.', 'On the contrary, a marked reduction of LC signal was observed in patients suffering from neurodegenerative disorders, with specific features.', 'LC-MRI is a promising tool, which may be used in the future to explore LC pathophysiology as well as an early biomarker for degenerative diseases.'], ["Our aim is to demonstrate that they provide a clinical significance in aging and in frequent neurodegenerative diseases such as Parkinson's disease, Huntington, and amyotrophic lateral sclerosis.", 'We confirm that variability indices are relevant indicators of aging process and neurodegenerative diseases.', 'While CV is sensitive to aging process and pathology, it does not discriminate between specific neurodegenerative diseases.', 'We conclude that the computation of H complements the clinical diagnosis of walking in patients with neurodegenerative diseases and we recommend it as a relevant supplement to classical CV or averaged SI.'], ['Cortical thinning occurs throughout the entire life and extends to late-life neurodegeneration, yet the neurobiological substrates are poorly understood.', 'These findings suggest a role of astrocytes and microglia in promoting and supporting neuronal growth and dendritic structures through life that affects cortical thickness during development, aging, and neurodegeneration.'], ['Several characteristics of aging individuals and their medical care have a potential to augment nocebo susceptibility, such as depression and anxiety, neurodegenerative diseases and chronic pain states, adverse healthcare experiences, generic drug use, age-related stereotypes, and strained patient-physician communication.'], ['BACKGROUND: Lateral recess stenosis (LRS) is a common degenerative disease in the elderly.'], ['Epigenetic aberration is implicated in aging and neurodegeneration.', 'These results have found a novel epigenetic mechanism and a potential therapeutic strategy for AD and related neurodegenerative disorders.'], ["Human DNA methylation data have been used to develop biomarkers of ageing, referred to as 'epigenetic clocks', which have been widely used to identify differences between chronological age and biological age in health and disease including neurodegeneration, dementia and other brain phenotypes.", 'Our findings suggest that previous associations between predicted DNA methylation age and neurodegenerative phenotypes might represent false positives resulting from clocks not robustly calibrated to the tissue being tested and for phenotypes that become manifest in older ages.'], ['BACKGROUND: A considerable portion of the elderly population are increasingly afflicted by degenerative spinal deformity (DSD), which seriously affects patient health-related quality of life (HRQoL).', 'HRQoL index is used across many studies to show correlations between radio-graphical alignment, disability, and pain in patients with DSD.', 'However, imaged structural deformity represents only one aspect for consideration, namely, the disability effect of DSD.', 'We assessed the isokinetic strength of trunk muscle in patients with degenerative spinal deformity (DSD), and investigated its relationship with HRQoL.', 'METHODS: In total, 38 patients with DSD (DSD group) and 32 healthy individuals (control group) were recruited.', 'RESULTS: When compared with the control group, the DSD group showed lower trunk extensor strength at three velocity movements, and higher F/E ratios at 60 and 120 /s (p < 0.05).', 'In DSD group, trunk extensor strength at 60 /s was negatively associated with ODI and RDQ (p < 0.05).', 'CONCLUSIONS: We identified isolated trunk extensor myopathy in DSD, which causes an imbalance in trunk muscle strength.', 'Isokinetic trunk extensor strength at 60 /s and trunk flexor strength at 120 /s can predict disability, and decrease physical HRQoL in DSD patients.'], ['Evidence suggests that mitochondrial function in lymphocytes are potential biomarkers in the progression of neurodegeneration, as peripheral mitochondrial function is associated with mild cognitive impairment (MCI) in the elderly population.'], ['There has been a long argument over whether schizophrenia is a neurodegenerative disorder associated with progressive cognitive impairment.'], ['The results on human SH-SY5Y indicate that the unlabeled N2S2-KDP may perhaps be useful for neurite growth in neurodegenerative disorder.'], ["Olfactory function declines in the early stage of neurodegenerative diseases, including Alzheimer's and Parkinson's diseases.", 'Moreover, the assessment of hyposmia and anosmia is paramount to the diagnosis of neurodegenerative diseases.'], ['We showed that inactivation of one particular gene, fkh-2/FOXG1, enhanced the motility defect, neurodegeneration and reduced longevity in our MJD models.', 'Opposite to genetic inactivation, the overexpression of fkh-2 rescued the impaired motility, shortened-lifespan, and neurodegeneration phenotypes of mutant ATXN3 transgenics.', 'Using our transgenic ATXN3 C. elegans models and the screening of an RNAi library, we gained insights into the pathways contributing to neurodegeneration, and found that FKH-2/FOXG1 has neuroprotective activity.'], ["Parkinson's disease (PD), as the second most common neurodegenerative disease, is caused by complex pathological processes and currently remains very difficult to treat."], ['Given the importance of the DDR in suppressing mutations and human diseases such as neurodegeneration, immunodeficiencies, cancer and aging, RNA modification pathways may be involved in human diseases not solely through their roles in gene expression but also by their ability to impact DNA repair and genome stability.'], ["This distinction is particularly important as the alERC is one of the earliest cortical regions affected by Alzheimer's pathology and related neurodegeneration."], ["Parkinson's disease is the second most common neurodegenerative disorder in old age."], ['AGE-related diseases include physiological aging, neurodegenerative/neuroinflammatory diseases, diabetes mellitus (DM) and its complications, autoimmune/rheumatic inflammatory diseases, bone-degenerative diseases, and chronic renal diseases.'], ['Although the underlying etiologies are unknown in many patients, the TLE-MCI phenotype may be secondary to an accumulation of epilepsy and vascular risk factors, signal the onset of a neurodegenerative disease, or represent a combination of factors.'], ['Niemann-Pick disease type C (NPC) is a neurodegenerative disease in which mutation of NPC1 or NPC2 gene leads to lysosomal accumulation of unesterified cholesterol and sphingolipids.'], ["In normal old (Nold) and Alzheimer's disease (AD) persons, a high cognitive reserve (CR) makes them more resistant and resilient to brain neuropathology and neurodegeneration."], ['BACKGROUND: Vitamins D and K, which are present in human brain, may have a role in neurodegenerative disease.'], ['Establishing transcriptome-based hallmarks of human brain aging will improve the understanding of cognitive aging and neurodegenerative diseases and eventually lead to interventions that delay or prevent brain aging.'], ['Multiple Sclerosis (MS) is a neurodegenerative disease characterized by multiple focal lesions, ongoing demyelination and, for most people, a lack of remyelination.'], ['With an aging population and increased prevalence of neurodegenerative disease, the indication for MRI exams in patients with such implants increases as well.'], ['In the current outbreak of metabolic diseases such as cardiometabolic disorders, cancer and neurodegenerative diseases, metabolomics appears to be ideally situated for the investigation of disease pathophysiology from a metabolite perspective.'], ['In contrast to induced pluripotent stem cell-derived neurons, miRNA-induced neurons (miNs) retain the biological age of the starting fibroblasts through direct fate conversion and thus provide a human neuron-based platform to study cellular properties inherent in aged neurons and model adult-onset neurodegenerative disorders using patient-derived cells.'], ["Alzheimer's disease (AD) is the most prevalent neurodegenerative disorder and the most common form of dementia in the elderly."], ['It has been reported that anti-inflammatory and insulin-sensitizing compounds delay, or reverse, the aging process and prevent metabolic disorders, neurodegenerative disease, and muscle atrophy, improving healthspan and extending lifespan.'], ["Alzheimer's disease (AD) is a type of neurodegenerative dementia caused by the accumulation of abnormal proteins."], ['CONCLUSIONS: This study provides novel associations of genetic factors to Abeta accumulation and AD-related neurodegeneration to influence AD susceptibility.'], ['Tauopathies is a class of neurodegenerative disorders which involves the transformation of physiological tau into pathogenic tau.'], ["These findings suggest that plasma NfL increases in response to amyloid-related neuronal injury in preclinical stages of Alzheimer's disease, but is related to tau-mediated neurodegeneration in symptomatic patients."], ["Due to the aging population in the world, neurodegenerative diseases have become a serious public health issue that greatly impacts patients' quality of life and adds a huge economic burden.", 'Even after decades of research, there is no effective curative treatment for neurodegenerative diseases.', 'Polyunsaturated fatty acids (PUFAs) have become an emerging dietary medical intervention for health maintenance and treatment of diseases, including neurodegenerative diseases.', "Recent research demonstrated that the oxidized metabolites, particularly the cytochrome P450 (CYP) metabolites, of PUFAs are beneficial to several neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease; however, their mechanism(s) remains unclear.", 'We will also discuss the potential mechanism(s) of CYP PUFA metabolites in neurodegeneration, which will ultimately improve our understanding of how PUFAs affect neurodegeneration and may identify potential drug targets for neurodegenerative diseases.'], ['There is considerable debate about whether MCI is a useful clinical diagnosis, or whether the use of the term prevents proper inquiry (by history, examination and investigations) into underlying causes of cognitive symptoms, which can include prodromal neurodegenerative disease, other physical or psychiatric illness, or combinations thereof.'], ['However, in neurodegenerative diseases, whose pathogenesis is closely related to advanced age, ACE2 plays a neurotrophic and protective role by activating the ACE2/Ang-(1-7)/Mas axis, thus inhibiting cognitive impairment.', 'Therefore, during the COVID-19 pandemic, it is crucial to understand the role of ACE2 in neurodegenerative diseases.', 'In this paper, we review the relationship between COVID-19, neurodegenerative diseases, and ACE2, as well as provide recommendations for the protection of elderly patients with neurodegenerative diseases during the COVID-19 pandemic.'], ['This decline is the primary risk factor for prominent human pathologies such as cancer, metabolic disorders, cardiovascular disorders, and neurodegenerative diseases.'], ["Alzheimer's disease (AD) is a neurodegenerative disease which is manifested by a progressive and irreversible decline of cognition, memory loss, a shortened attention span, and changes in personality.", "Recent epidemiological studies show that both metals possibly are etiological factors of multiple neurodegenerative diseases, including Alzheimer's disease (AD)."], ['Finally, we have emphasized the effects of UHHPBR in human cases with rare conditions such as osteoporosis and brain cognition - two age-related degenerative diseases of the elderly population.'], ['Neurodegenerative diseases (NDs) are common chronic diseases related to progressive damage of the nervous system.', 'Globally, the number of people with an ND is dramatically increasing consistent with the fast aging of society and one of the common features of NDs is the abnormal aggregation of diverse proteins.', 'It has been found that the impairment of autophagy is associated with many NDs, suggesting that autophagy has a vital role in the neurodegeneration process.', 'Recently, more and more studies have reported that autophagy inducers display a protective role in different ND experimental models, suggesting that enhancement of autophagy could be a potential therapy for NDs.', "In this review, the evidence for beneficial effects of traditional Chinese medicine (TCM) regulate autophagy in the models of Alzheimer's disease (AD), Parkinson's disease (PD), and other NDs are presented and common autophagy-related mechanisms are identified."], ["This activity is mainly associated with the suppression of oxidative stress, as well as it could be related to neuroprotective, cardioprotective, and metabolic functions.It might be speculated that Klotho, regarded as a neuroprotective factor, may have therapeutical applications in the future in the treatment of demyelinating and neurodegenerative disorders, especially multiple sclerosis (MS) and Alzheimer's disease (AD)."], ["These observations highlight the importance of investigating the association between COVID-19 and age-related neurodegenerative disorders, i.e., Parkinson's and Alzheimer's diseases."], ["Aging drives pathological accumulation of proteins such as tau, causing neurodegenerative dementia disorders like Alzheimer's disease."], ["INTRODUCTION: Ageing leads to physiological cognitive decline that it is worsened in people with neurodegenerative diseases such as Alzheimer's disease."], ['Cell-penetrating peptides are a promising therapeutic strategy for a wide variety of degenerative diseases, ageing, and cancer.'], ['The Montefiore-Einstein Center for the Aging Brain, a specialty multidisciplinary center for the evaluation and management of patients with neurodegenerative disorders, developed a coordinated approach (Coordinated Care At Risk/Remote Elderly program [CCARRE]) to reach our diverse population during the initial Covid-19 crisis in New York City, USA.'], ['Neurodegenerative diseases (ND) can be characterized by degradation and subsequent loss of neurons.', 'ND has been identified as the leading cause of disability-adjusted life years (DALYs) worldwide and is associated with various risk factors such as ageing, certain genetic polymorphisms, inflammation, immune and metabolic conditions that may induce elevated reactive oxygen species (ROS) release and subsequent oxidative stress.', 'Presently, no specific cure or prevention is available for ND patients; the symptoms can be only alleviated via drug treatment or surgery.', 'The evidence and proposed mechanism of OPP on the neuroprotective health may provide a comprehensive natural medicine approach to alleviate the symptoms of neurodegenerative diseases.'], ["More than 50 million people have various forms of cognitive impairment basically caused by neurodegenerative diseases, such as Alzheimer's, Parkinson's, and cerebrovascular diseases as well as stroke.", 'The damaged area in post-stroke dementia may lead to neurodegenerative lesions.', 'These may coexist in various patterns in older people, enhancing the risk, incidence, and progression of cerebrovascular lesions, neurodegenerative disorders, and cognitive impairment, creating a vicious circle.'], ["However, recent studies have shown that tooth loss and occlusal dysfunction may affect brain function and trigger the onset of dementia found in neurodegenerative diseases including Alzheimer's disease."], ['However, people living with HIV experience tradeoffs with quality of life often developing age-associated co-morbid conditions such as cancers, cardiovascular diseases, or neurodegeneration due to chronic immune activation and inflammation.'], ['Neurodegenerative diseases (ND) have been linked to the critical process in aging-cellular senescence.', 'However, the temporal dynamics of cellular senescence in ND conditions is unresolved.'], ['Lewy body disease (LBD) is a spectrum of progressive neurodegenerative disorders characterized by the wide distribution of Lewy bodies and neurites in the central and peripheral nervous system (CNS, PNS).'], ['The Arizona Study of Aging and Neurodegenerative Disorders/Brain and Body Donation Program at Banner Sun Health Research Institute (BSHRI) is a longitudinal clinicopathological study with a current enrollment of more than 900 living subjects for aging and neurodegenerative disease research.', "Since 2018, the program has undertaken banking of scalp fibroblasts derived from neuropathologically characterized donors with Alzheimer's disease, Parkinson's disease, and other neurodegenerative diseases."], ['Aging is a normal human cycle and the most important risk factor for neurodegenerative diseases.'], ['The discovery of the glial-lymphatic or glymphatic fluid clearance pathway in the rodent brain led researchers to search for a parallel system in humans and to question the implications of this pathway in neurodegenerative diseases.'], ["INTRODUCTION: To investigate whether neurodegeneration underlying Parkinson's disease (PD) accounts for a substantial proportion of cases of minimal parkinsonism in the elderly.", 'All subjects did not show findings compatible with PD on 18F-FP-CIT PET scans, and had no evidence of other neurodegenerative disorders.'], ["Alzheimer's Disease (AD) is a progressive multifactorial age-related neurodegenerative disorder that causes the majority of deaths due to dementia in the elderly."], ['BACKGROUND: Knee osteoarthritis (KOA) is a common chronic degenerative disorder with an increasingly prevalence among the older individuals and the leading cause of pain in the elderly.'], ["The vast increase of world's aging populations is associated with increased risk of age-related neurodegenerative diseases such as Parkinson's disease (PD)."], ['Collectively, based on the present findings and those of previous studies, we can conclude that the combination of NIR-T/BSS or NIRS signals and time-frequency analysis opens new frontiers in science, and give possibility to understand and diagnosis of various neurodegenerative and ageing related diseases to improve diagnostic procedures and patient prognosis.'], ['Impairments in autophagy are central to the pathogenesis of many conditions including metabolic and neurodegenerative disorders, cardiovascular and pulmonary diseases, diabetes, and aging.'], ['Similar changes were present in aged human microglia and in damage-associated microglia, indicating that upregulation of mTOR-dependent translation is an essential aspect of microglia priming in aging and neurodegeneration.'], ['The global burden of neurodegenerative diseases underscores the urgent need for innovative strategies to define new drug targets and disease-modifying factors.', "More recently, the considerable attributes of C. elegans have been applied to neurodegenerative diseases, including amyotrophic lateral sclerosis, Alzheimer's disease, Parkinson's disease and Huntington's disease.", 'The anatomical transparency of C. elegans affords the use of co-expressed fluorescent proteins to follow the progression of neurodegeneration as the animals age.', 'Significantly, a completely defined connectome facilitates detailed understanding of the impact of neurodegeneration on organismal health and offers a unique capacity to accurately link cell death with behavioral dysfunction or phenotypic variation in vivo Moreover, chemical treatments, as well as forward and reverse genetic screening, hasten the identification of modifiers that alter neurodegeneration.', 'Here, we outline the methodologies employed to investigate neurodegeneration in C. elegans and highlight numerous studies that exemplify its utility as a pre-clinical intermediary to expedite and inform mammalian translational research.'], ['Thus we report strategies that additionally undermine downstream inflammasome signaling in bats, limiting an overactive immune response against pathogens while potentially producing an antiinflammatory state resistant to diseases such as atherosclerosis, aging, and neurodegeneration.'], ["Alzheimer's disease (AD) is the most common neurodegenerative disease caused by eventually aggregated amyloid beta (Abeta) plaques in degenerating neurons of the aging brain.", 'Even though some cholinesterase inhibitors, NMDA receptor antagonist, and monoclonal antibodies were developed to inhibit neurodegeneration or activate neural regeneration or clear off the Abeta deposits, none of the treatment is effective in improving the cognitive and memory dysfunctions of the AD patients.'], ['The association of elevated CSF iron and copper with tau could represent findings of increased neurodegeneration in these patients.'], ['BACKGROUND: Several dietary components have been shown to be neuroprotective against risk of neurodegeneration.'], ['BACKGROUND: Music-based interventions appear to be efficient approaches to improve emotional, social, and cognitive functioning of patients with neurodegenerative diseases.'], ['Age-related decrease in sirtuins expression induces many pathophysiological processes that could lead to neurodegeneration.'], ["Recent data suggest gut microbiota dysbiosis as a contributing factor in neurodegenerative diseases, such as Parkinson's Disease (PD) and Alzheimer's Disease (AD), and these pathologies may manifest via the microbiota-gut-brain-axis, which comprises bidirectional communication through neuroimmune, neuroendocrine, and direct neural pathways such as the vagus nerve.", 'Preclinical and human clinical trial data reveal exciting potential for novel treatment targets and therapeutic modulation with prebiotics, medicinal herbs, probiotics, and synbiotics in health, aging, and neurodegeneration and are reviewed here.', 'While greater insights and characterization of the microbiota-gut-brain axis have been revealed over the past decade, salient questions related to the pathology, pathogenesis and clinical treatment of the axis in the context of both health and neurodegenerative disease remain and are discussed in this review.'], ["Parkinson's disease (PD) is a common neurodegenerative disorder with the pathological hallmark of alpha-synuclein aggregation."], ['This state of affairs has persisted despite the central importance of glutamate neurotransmission in brain physiology and in disorders such as stroke, epilepsy, schizophrenia, and neurodegenerative diseases.'], ['This frontal alpha oscillation is known to decline significantly during aging and is generated by prefrontal brain regions that are particularly prone to age-related neurodegeneration.'], ['The leading cause of central vision loss, age-related macular degeneration (AMD), is a degenerative disorder characterized by atrophy of retinal pigment epithelium (RPE) and photoreceptors.'], ['However, emerging evidence from animal and human studies has suggested that chronic exposures to air pollution detrimentally change the functioning of the central nervous system with the result being proteinopathy, neurocognitive impairment, and neurodegenerative disease.', "The goal of this report was to explore the neuroscientific support for the hypothesis that inhaled particulate matter might cause an Alzheimer's-like neurodegenerative disease, in order to consider proposed mechanisms and latency periods linking inhaled particulate matter and neurodegeneration, and to propose new directions in this line of research."], ['Oxidative stress alters cell viability, from microorganism irradiation sensitivity to human aging and neurodegeneration.'], ['Neurofibrillary tangles arising from aggregated microtubule-associated protein tau occur in aged brains and are hallmarks of neurodegenerative diseases.'], ['The preventive effects of tocotrienol on vascular disease, cancer, neurodegeneration and aging are attributed to its effects on cellular apoptosis and senescence.'], ['Since mild mitochondrial uncoupling emerged as a valuable therapeutic approach by regulating oxidative stress in most prevalent human diseases including ageing, ischemic reperfusion injury, and neurodegeneration with comparable features of IR inflicted mitochondrial damage.'], ['The research focuses on four selected neurodegenerative diseases: Alzheimer, Parkinson, vascular dementia, and amyotrophic lateral sclerosis.'], ['Nevertheless, the overlapping of neurodegenerative diseases affects the long-term shunt efficacy and this occurrence should be detected before surgery.', 'Conclusions: Low level of P-Tau is a useful CSF biochemical prognostic factor for good clinical outcome at least two years after shunt; meanwhile a lower Abeta1-42 might suggest that the pathophysiology of iNPH could have something in common with other neurodegenerative diseases of the elderly.'], ['Direct cell reprogramming is an excellent alternative and a valuable supplement to the iPSC-based technologies both as a source of mature cells for modeling of neurodegenerative diseases, and as a novel powerful strategy for in vivo cell replacement therapy.'], ["Alzheimer's disease (AD) is a progressive neurodegenerative disorder leading to the most common form of dementia in elderly people.", "Consequently, wine polyphenols health effects, mediated as a function of the individual's oral and gut microbiome are considered one of the recent greatest challenges in the field of neurodegenerative diseases as a promising strategy to prevent or slow down AD progression."], ["Alzheimer's disease (AD) is an age-related dementia and neurodegenerative disorder, characterized by Abeta and tau protein deposition impairing learning, memory and suppressing synaptic plasticity of neurons.", 'Here, we review data supporting the involvement of the glutamatergic system in AD pathophysiology as well as the efficacy of glutamatergic agents in this neurodegenerative disorder.'], ['BACKGROUND: Transcranial direct current stimulation (tDCS) is widely investigated as a therapeutic tool to enhance cognitive function in older adults with and without neurodegenerative disease.'], ['CMA regulates the abundance of many disease-related proteins, with causative roles in neoplasia, neurodegeneration, hepatosteatosis, and other pathologies relevant to human health and aging.'], ['Cellular stress response and neurodegeneration gene signatures were aberrantly expressed in CAVD, pointing to a mechanistic link between chronic inflammation and biological aging.'], ['Although iron has been demonstrated in amyloid plaques and in association with neurodegeneration, it is of insufficient quantity to be reliably detected in the cortex using this implementation of QSM.'], ["BACKGROUND: Mendelian Randomization (MR) studies exploiting single nucleotide polymorphisms (SNPs) predictive of leukocyte telomere length (LTL) have suggested that shorter genetically determined telomere length (gTL) is associated with increased risks of degenerative diseases, including cardiovascular and Alzheimer's diseases, while longer gTL is associated with increased cancer risks.", 'RESULTS: Our analysis shows that, despite the markedly larger ORs of neoplastic disease, the large incidence of degenerative diseases causes the excess incidence attributable to gTL to balance that of neoplastic diseases.'], ['Indeed, this neurodegenerative disorder is not exclusively neurological, but rather may involve multiple tissues and organs.'], ["Adenosine is a neuromodulator that has been involved in aging and neurodegenerative diseases as Alzheimer's disease (AD)."], ['Iron plays important roles in healthy brain but altered homeostasis and concentration have been correlated to aging and neurodegenerative diseases.'], ["Advanced brain aging is commonly regarded as a risk factor for neurodegenerative diseases, for example, Alzheimer's dementia, and it was suggested that sleep disorders such as obstructive sleep apnea (OSA) are significantly contributing factors to these neurodegenerative processes.", 'Our results reveal an association between OSA and brain age, indicating subtle but widespread age-related changes in regional brain structures, in one of the largest general population studies to date, warranting further examination of OSA in the prevention of neurodegenerative diseases.'], ['Compared with all participants who developed cancer as a primary condition, individuals who experienced mental disorders/neurodegenerative disorders and a comorbidity as cardiovascular disease, hypertension, dyslipidemia, diabetes, asthma, or osteoarthritis were 3.36-10.87 times more likely to develop cancer as a tertiary condition.', 'Individuals with neurodegenerative disorders and a comorbidity as hypertension, dyslipidemia, osteoarthritis, or asthma were 5.14-14.15 times more likely to develop mental disorders as a tertiary condition.'], ['Also, the contribution of the proposed predictions of AD is a better selection of patients who need imaging diagnostics for differential diagnosis of AD from other degenerative brain disorders.'], ["BACKGROUND: Parkinson's disease (PD) is a neurodegenerative disease of the elderly, which leads to patients' motor and non-motor disabilities and affects patients' quality of daily life."], ['In both NSCLC and SCLC patients, neither crude nor cumulative incidences of secondary endpoints in the very elderly group, i.e., neurological death, neurological deterioration, local recurrence, repeat SRS, salvage whole brain radiotherapy and SRS-related complications, were shown to be unfavorable to those in the elderly group.'], ["Parkinson's disease (PD) is a progressive neurodegenerative disease resulting from the degeneration of dopaminergic (DAergic) neurons in the substantia nigra pars compacta (SNpc) and subsequent deficit of dopamine in the striatum."], ['The interaction of chronic inflammation with age-associated degeneration places these individuals at increased risk of accelerated aging and other neurodegenerative diseases and no treatments are available that effectively halt these processes.'], ['During the study period we found a substantial increase in the all-age burden of neurodegenerative diseases, despite a substantial decrease in the rates of stroke and infections.'], ["Parkinson's disease (PD) is one of the most common neurodegenerative disorders."], ['Telomeres are protective structures that are shortened during the lifetime, resulting in aging and degenerative diseases.', 'Subjects experiencing aging and degenerative disorders present smaller telomeres than young and healthy ones.', 'I concluded that telomerase is probably a potential and safe treatment for aging and degenerative diseases, demonstrating neither side effects nor risk of cancer in the selected studies.'], ['Recent studies in animal models demonstrate that certain misfolded proteins associated with neurodegenerative diseases can support templated misfolding of cognate native proteins, to propagate across neural systems, and to therefore have some of the properties of classical prion diseases like Creutzfeldt-Jakob disease.', 'The committee concluded that, based on all currently available data, although neurodegenerative disease-associated aggregates of several different non-prion proteins can be propagated from humans to experimental animals, there is currently insufficient evidence to suggest more than a negligible risk, if any, of a direct infectious etiology for the human neurodegenerative disorders defined in part by these proteins.'], ['Most studies focused on cardiovascular disorders (CVD), type 2 diabetes (T2D), and neurodegenerative disorders.'], ['In this review article, we present recent evidence towards the elucidation of the impact of ER on brain physiology and in age-related neurodegenerative diseases.'], ['Neurodegenerative diseases affect the lives of millions of people across the world, being particularly prevalent in the aging population.', 'A common histopathological hallmark of many neurodegenerative diseases is the presence of large pathognomonic protein aggregates, but their role in the disease pathology is unclear and subject to controversy.', 'Multidisciplinary approaches are key for understanding neurodegenerative diseases and may contribute to the development of effective treatments.'], ['As such, inhibition of ferroptosis may be a means to extend healthspan and treat frailty and possibly neurodegenerative diseases that have a reported role for iron dyshomeostasis.'], ['Neurodegenerative disorders are common among aging populations around the globe.', 'In the need to identify an alternative approach, researchers successfully demonstrated the therapeutic utility of plant-derived nutraceuticals in cell and animal models of neurodegenerative conditions.', 'Here, we review the research advances in nanoparticles conjugated nutraceuticals applied in neurodegenerative disorders and discuss their advantages and limitations, clinical trials and toxicity concerns.'], ["In the human-macaque comparison, the two other neurodegenerative diseases (Alzheimer's and Huntington's) are added to the enriched pathways.", 'These results can be useful for understanding the variation in longevity and susceptibility to cancer and widespread neurodegenerative diseases.'], ['Most studies did not examine amyloid, tau, or neurodegeneration biomarkers.', 'Delirium may be associated with neurodegeneration biomarkers, but few to no studies found an association with amyloid and tau biomarkers.'], ['Mutations in mtDNA cause a number of rare, human disorders and are also associated with more common conditions, such as neurodegeneration and biological aging.'], ['Major healthcare challenges involved with caring for the elderly in China include the management of chronic non-communicable diseases (CNCDs), physical frailty, neurodegenerative diseases, cardiovascular diseases, with emerging challenges such as providing sufficient dental care, combating the rising prevalence of sexually transmitted diseases among nursing home communities, providing support for increased incidences of immune diseases, and the growing necessity to provide palliative care for the elderly.'], ["Alzheimer's disease (AD) is the most common neurodegenerative disease, yet there are no disease-modifying treatments available and there is no cure."], ["Easily accessible biomarkers for Alzheimer's disease (AD), Parkinson's disease (PD), frontotemporal dementia (FTD), and related neurodegenerative disorders are urgently needed in an aging society to assist early-stage diagnoses.", 'In this study, we aimed to develop machine learning algorithms using the multiplex blood-based biomarkers to identify patients with different neurodegenerative diseases.', 'We applied machine learning-based frameworks, including a linear discriminant analysis (LDA), for feature extraction and several classifiers, using features from these blood-based biomarkers to classify these neurodegenerative disorders.', 'The developed LDA model with the RF classifier can assist clinicians in distinguishing variable neurodegenerative disorders.'], ['These issues may impact drug use cessation as well as outcomes with aging and age-related neurodegenerative diseases in women.'], ['As such, research on how the human ageing process evolved is vital to understanding the origins of prolonged human lifespan and factors increasing vulnerability to degenerative disease.'], ['Humans are considered uniquely susceptible to neurodegenerative disorders, although recent studies have revealed Abeta and tau pathology in non-human primate brains.'], ['The increase in the average age of the population worldwide is, however, becoming a real concern, since aging is associated with the rapid increase in chronic inflammatory pathologies and degenerative diseases, very frequently dependent on senescent phenomena that occur alongside with senescence.'], ["Proteinopathies are key elements in the pathogenesis of age-related neurodegenerative diseases, particularly Alzheimer's disease (AD), with the nature and location of the proteinopathy characterizing much of the disease phenotype.", 'Our findings provide evidence that compromised DMN connectivity, in the context of preclinical AD, foreshadows neurodegeneration in DMN regions.'], ["We sought to evaluate whether informant questionnaires for basic and instrumental activities of daily living, or for identifying progressive cognitive decline would improve diagnostic predictability of neurodegenerative disorders compared with either the Consortium to Establish a Registry for Alzheimer's Disease (CERAD) neuropsychological test battery or the Mini-Mental State Examination score alone."], ['Osteoporosis is one of the most common age-related degenerative diseases, and its progression correlates with aging and decreased capacity for stem cell differentiation and proliferation in both men and women.'], ['Impaired cargo trafficking and the aggregation of intracellular macromolecules are key features of neurodegeneration, and a hallmark of aged as well as diseased retinal pigment epithelial (RPE) cells in the eye.'], ['Chelation of brain iron is thus a promising therapeutic strategy for improving behavioral outcomes and slowing neurodegeneration in the aforementioned disease states, though the effectiveness of DFO treatment is limited on several accounts.', "These limitations necessitate novel DFO formulations prior to the drug's widespread use in managing neurodegeneration.", 'The clinical progress of chelation therapy with DFO in managing neurodegeneration is also evaluated.', 'DFO is a strong drug candidate for managing neurodegeneration in the aging population, but before it can be routinely implemented as a therapeutic agent, dosing regimens must be standardized, and brain DFO content following drug administration must be understood and controlled via novel formulations.'], ["Alzheimer's disease (AD) is a complex neurodegenerative disorder and the most common type of dementia in the elderly.", 'Our results support the hypothesis that AD is a condition with increased oxidative stress and genomic instability, which may contribute to the neurodegeneration in AD.'], ['METHODS: For the purpose of review, we carried out an extensive literature study to excerpt the series of steps involved in autophagy and to understand the mechanism of autophagic impairment occurring in a range of neurodegenerative and neuropsychiatric disorders like Parkinson, Alzheimer, Depression, Schizophrenia, Autism etc.', 'CONCLUSION: Autophagy is a significant process for the removal of misfolded, abnormal, damaged protein aggregates and nonfunctional cell organelles in order to suppress neurodegeneration.'], ["Alzheimer's disease (AD) is an age-related neurodegenerative disease, of which beta-amyloid (Abeta)-induced toxicity has been suggested as a main cause."], ['This includes the onset and progression of classic degenerative diseases such as cardiovascular disease, kidney failure, neurodegenerative diseases, and cancer.'], ['CONCLUSIONS: The study results demonstrate that odor identification impairment has prognostic value in progressive MS, suggesting that a brief odor identification measure can be a marker of neurodegeneration in progressive MS.'], ["Alzheimer's disease (AD) is a progressive neurodegenerative disease that is the major cause of dementia in older people."], ["The findings highlight a potential opportunity for empirically supported sleep interventions.Implications for rehabilitationParkinson's disease is a progressive neurological condition that impacts patient and caregiver quality of life.Patient sleep problems contribute to greater caregiver burden, sleep problems, and reduced life satisfaction.The findings suggest patient and caregiver sleep may be a worthwhile target for intervention in order to reduce risk of caregiver burden and improve life satisfaction."], ["INTRODUCTION: Alzheimer's disease (AD) is a degenerative brain disease that progresses over time, heavily burdening patients, families, and aging societies worldwide."], ['PURPOSE: A fundamental goal in the drive to understand and find better treatments for dementia is the identification of the factors that render the aging brain vulnerable to neurodegenerative disease.'], ['Accordingly, food as medicine may be the most suitable approach for the treatment of this degenerative disease.'], ["BACKGROUND: alpha-Synuclein (aSyn) aggregation is thought to play a central role in neurodegenerative disorders termed synucleinopathies, including Parkinson's disease (PD).", 'Our findings highlight the importance of membrane-induced self-assembly in aSyn neurotoxicity and suggest that inhibiting this process by targeting the C-terminal domain could slow neurodegeneration in PD and other synucleinopathy disorders.'], ['Osteoarthritis (OA) is the most common degenerative joint disease, predicted to increase in incidence year by year due to an ageing population.'], ['As with most other neurodegenerative diseases, clinical signs of the disease usually show among the elderly population, and most commonly around 60-65 years of age.', 'We recruited 511 patients diagnosed with ALS according to the revised El Escorial criteria, and 236 control cases without a neurodegenerative disease.'], ["Finally, we also review the epidemiology of nOH based on the underlying neurodegenerative disorder (either Parkinson's disease or multiple system atrophy), and the presence of co-morbid conditions such as hypertension and cognitive impairment."], ['The neuroprotective effects of GDNF may be used to develop treatments and therapies to ameliorate neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS).'], ['METHODS: We conducted a descriptive case-control study of a sample of patients diagnosed with primary neurodegenerative dementia.'], ['Indeed, emerging evidence indicates that mitochondrial biogenesis regulators play important roles in the onset and progression of severe neurodegenerative syndromes such as AD, PD and HD.'], ['The molecular signatures of cells in the brain have been revealed in unprecedented detail, yet the ageing-associated genome-wide expression changes that may contribute to neurovascular dysfunction in neurodegenerative diseases remain elusive.'], ["If bilingualism plays an ameliorative role against the expression of neurodegeneration in dementia, it is possible that it could have similar effects for other neurodegenerative disorders, including Multiple Sclerosis, Parkinson's and Huntington's Diseases.", 'Herein, we provide a roadmap that reviews the relevant literatures, highlighting potential links across neurodegenerative disorders and bilingualism more generally.'], ["In other words, our findings suggest that CR compensates the neurodegeneration and allows the maintenance of patients' cognitive performance."], ['Lateral lumbar interbody fusion (LLIF) is a minimally invasive procedure that is commonly used to treat degenerative spine disease.', 'METHODS: Patients who underwent 3D-navigated LLIF for degenerative disease from 2014 to 2019 were included in the analysis.'], ['Besides, since iron plays an important role in both neuroprotection and neurodegeneration, dietary iron homeostasis should be considered with caution.'], ['Among these age-related diseases, neurodegenerative diseases have attracted considerable attention because of their irreversibility, the absence of effective treatment and their relationship with social and economic pressures.', 'Mechanistic (formerly mammalian) target of rapamycin (mTOR), sirtuin (SIRT) and insulin/insulin growth factor 1 (IGF1) signalling pathways are among the most important pathways in ageing-associated conditions, such as neurodegeneration.', 'In this review, we discuss the roles of sirtuin and mTOR in ageing and neurodegeneration, with an emphasis on their regulation of autophagy, apoptosis and mitochondrial energy metabolism.', "The intervention of neurodegeneration using potential antioxidants, including vitamins, phytochemicals, resveratrol, herbals, curcumin, coenzyme Q10 and minerals, specifically aimed at retaining mitochondrial function in the treatment of Alzheimer's disease, Parkinson's disease and Huntington's disease is highlighted."], ['Notwithstanding their detrimental effects on the human life quality and the healthcare system, the majority of human neurodegenerative disorders still remain incurable and non-preventable.', 'A combination of these animal neurodegeneration models, together with genetic and pharmacological screens for cell death modulators will lead to an unprecedented understanding of age-related breakdown of neuronal function and will provide critical insights with broad relevance to human health and quality of life.'], ["Parkinson's disease is a common degenerative disease of the elderly."], ['STUDY OBJECTIVES: Age-related changes in sleep include a reduction in total sleep time and a greater incidence of sleep disorders, and are also an integral part of neurodegenerations.'], ['Outcomes of interest were rate of intravenous tPA administration, hemorrhagic transformation (ICH), in-hospital neurological deterioration, and poor outcome defined as a composite of hospital discharge to long-term care facility or death.', 'There were no differences in ICH or neurological deterioration.', 'Octogenarians were not at risk for ICH or neurological deterioration after tPA administration.'], ['We highlight expression of VISTA across cell types and CNS diseases and discuss the function of VISTA in microglia and during CNS ageing, inflammation and neurodegeneration.'], ['Consequently, the basic question of whether macrostructural changes follow a cytoarchitectonic or functional organization across the adult lifespan and in age-related neurodegenerative disease remained open.'], ['Neurodegenerative disease is an umbrella term for different conditions which primarily affect the neurons in the human brain.', 'In the last century, significant research has been focused on mechanisms and risk factors relevant to the multifaceted etiopathogenesis of neurodegenerative diseases.', 'Currently, neurodegenerative diseases are incurable, and the treatments available only control the symptoms or delay the progression of the disease.', 'This review is aimed at characterizing the complex network of molecular mechanisms underpinning acute and chronic neurodegeneration, focusing on the disturbance in redox homeostasis, as a common mechanism behind five pivotal risk factors: aging, oxidative stress, inflammation, glycation, and vascular injury.', 'Considering the complex multifactorial nature of neurodegenerative diseases, a preventive strategy able to simultaneously target multiple risk factors and disease mechanisms at an early stage is most likely to be effective to slow/halt the progression of neurodegenerative diseases.'], ['Mitochondrial dysfunction plays a major role not only in the pathogenesis of many oxidative stress or age-related diseases such as neurodegenerative as well as mental disorders but also in normal aging.', 'There is evidence that oxidative stress and mitochondrial dysfunction are the most upstream and common events in the pathomechanisms of neurodegeneration.', 'These findings indicate that honeybush extracts could constitute candidates for the prevention of oxidative stress with an impact on aging processes and age-related neurodegenerative disorders potentially leading to the development of a condition-specific nutraceutical.'], ['Because P2X7Rs are localized in the CNS preferentially on microglia, but also at a lower density on neuroglia (astrocytes, oligodendrocytes) the stimulation of this receptor leads to the release of neurodegeneration-inducing bioactive molecules such as pro-inflammatory cytokines, chemokines, proteases, reactive oxygen and nitrogen molecules, and the excitotoxic glutamate/ATP.', "Various neurodegenerative reactions of the brain/spinal cord following acute harmful events (mechanical CNS damage, ischemia, status epilepticus) or chronic neurodegenerative diseases (neuropathic pain, Alzheimer's disease, Parkinson's disease, multiple sclerosis, amyotrophic lateral sclerosis) lead to a massive release of ATP via the leaky plasma membrane of neural tissue.", 'This causes cellular damage superimposed on the original consequences of neurodegeneration.', 'The aim of this review article is to summarize our present state of knowledge on the involvement of P2X7R-mediated events in neurodegenerative illnesses endangering especially the life quality and duration of the aged human population.'], ['OBJECTIVE: To improve epidemiologic knowledge of neurologic deterioration (ND) in patients with acute ischemic stroke (AIS).', 'METHODS: In this prospective observational study, we captured ND prospectively in 29,446 patients with AIS admitted to 15 hospitals in Korea within 7 days of stroke onset.', 'ND was defined as an increase in NIH Stroke Scale (NIHSS) score >=2 (total), or >=1 (motor or consciousness), or any new neurologic symptoms.', 'Change in incidence rate after stroke onset, causes, factors associated with ND, modified Rankin Scale (mRS) score at 3 months and 1 year, and a composite of stroke, myocardial infarction, and all-cause death at 1 year were assessed.', 'RESULTS: ND occurred in 4,299 (14.6%) patients.', 'Old age, female sex, diabetes, early arrival, large artery atherosclerosis as a stroke subtype, high NIHSS scores, glucose level, systolic blood pressure, leukocytosis at admission, recanalization therapy, TIA without a relevant lesion, and steno-occlusion of relevant arteries were associated with ND.', 'CONCLUSIONS: ND should be taken into consideration as a factor that may influence the outcome in acute ischemic stroke.'], ['SGs participate in various biological functions including response to apoptosis, inflammation, immune modulation, and signalling pathways; moreover, SGs are involved in pathogenesis of neurodegenerative diseases, viral infection, aging, cancers and many other diseases.'], ['It is uncertain if tau is directly responsible for these vascular changes by interacting directly with microvessels, and/or if it contributes indirectly via neurodegeneration and concurrent neuronal loss and inflammation.', 'Additional consideration of vascular-directed therapies and strategies that target tau in the vascular space may be required to restore normal function in neurodegenerative disease.'], ['Osteoarthritis (OA) is a degenerative disease resulting in irreversible, progressive destruction of articular cartilage1.'], ['Neurodegenerative diseases, mainly amyotrophic lateral sclerosis, Parkinson, Alzheimer, and rarer diseases, have gained the attention of healthcare service providers due to their impact on the economy of countries where healthcare is a public service.', 'Prostheses could recover some important disabilities such as motion and aphasia, reduce the cost of assistance and increase the life quality of people affected by neurodegenerative diseases.Due to recent advances in the field of artificial intelligence (AI) (deep learning, brain-inspired computational paradigms, nonlinear predictions, neuro-fuzzy modeling), the early prediction of neurodegenerative diseases is possible using state-of-the-art computational technologies.', 'The latest generation of artificial neural networks (ANNs) exploits capabilities such as online learning, fast training, high level knowledge representation, online evolution, learning by data and inferring rules.Wearable electronics is also developing rapidly and represents an important enabling technology to deploy physical and practical (noninvasive) devices using AI-based models for early prediction of neurodegenerative diseases and of intelligent prostheses.Here we describe how to apply advanced brain-inspired methods for inference and prediction, the evolving fuzzy neural network (EFuNN) paradigm and the spiking neural network (SNN) paradigm, and the system requirements to develop a wearable electronic prosthesis for functional rehabilitation.'], ['It is a debilitating, progressive neurodegeneration for which disease-modifying therapies do not exist.', "Previous studies have suggested that, for a subset of patients, dysregulation in hemostasis might be one of the molecular mechanisms that ultimately leads to the development of neurodegeneration resulting in cognitive decline that represents the most prominent symptomatic characteristic of Alzheimer's disease."], ["INTRODUCTION: Neurogranin is known to be significantly elevated in patients with Alzheimer's disease (AD) and may be an effective clinical predictor of cognitive decline and neurodegeneration."], ['Many neurodegenerative disorders, in which aberrant protein conformers aggregate into pathological inclusions, present the chronic activation of the PERK branch of the unfolded protein response.', 'To further investigate the role of the PERK pathway in neurodegenerative disorders, we focused on Down syndrome (DS), in which aging confers a high risk of Alzheimer disease (AD).'], ['INTRODUCTION: A number of MRI methods have been proposed to be useful, quantitative biomarkers of neurodegeneration in ageing.', 'The Calgary Normative Study (CNS) is an ongoing single-centre, prospective, longitudinal study that seeks to develop, test and assess quantitative magnetic resonance (MR) methods as potential biomarkers of neurodegeneration.'], ['The gut microbiome is increasingly implicated in modifying susceptibility to and progression of neurodegenerative diseases (NDs).', 'In this review, we discuss roles for the microbiome in aging and in NDs.', 'We assess animal studies of genetic and environmental models for NDs that investigate how manipulations of the microbiome causally impact the development of behavioral and neuropathological endophenotypes of disease.', 'We additionally evaluate the likely immunological, neuronal, and metabolic mechanisms for how the gut microbiota may modulate risk for NDs.', 'Finally, we speculate on cross-cutting features for microbial influences across multiple NDs and consider the potential for microbiome-targeted interventions for NDs.'], ['The results obtained allow us to affirm that the measurement of CR is considered an essential variable for the diagnosis of neurodegenerative diseases.'], ["It is a progressive neurodegenerative disease that affects elderly people's ability to perform daily living activities."], ['As a nodal mediator of pyruvate metabolism, the mitochondrial pyruvate carrier (MPC) plays a pivotal role in many physiological and pathological processes across the human lifespan, from embryonic development to aging-associated neurodegeneration.'], ['Age-dependent neurodegenerative disorders are a set of diseases that affect millions of individuals worldwide.'], ['BACKGROUND: Degenerative disorders of the lumbar spine decrease the mobility and quality of life of elderly patients.'], ['While cognitive changes in aging and neurodegenerative disease have been widely studied, language changes in these populations are less well understood.'], ['Functional hearing problems may be a preclinical marker of neurofibrillary neurodegeneration, although replication is needed.'], ["Patients with Parkinson's disease (PD) show a common progressive neurodegenerative movement disorder characterized by rigidity, tremors, postural instability, and bradykinesia due to the loss of dopaminergic neurons in the substantia nigra, and is often accompanied by several non-motor symptoms, called parkinsonism."], ["Parkinson's disease (PD) is the most common neurodegenerative motor disorder."], ['The extent of TBI-related neurophysiological abnormalities has been hypothesized to reflect AD-like neurodegeneration because TBI can increase vulnerability to AD.'], ["Alzheimer's disease (AD) is a common neurodegenerative disease with high incidence among old people."], ['Age-related cognitive decline and neurodegenerative diseases are associated with less functional neurogenic niches.', 'Whether this occurs in human neurogenic niches or to which extent T-cell infiltration is also taking place in neurodegenerative diseases remains unknown.', 'Moreover, we also found CD3+ and CD8+ T cells in the SVZ of individuals with neurodegenerative diseases.'], ['Lysosomes are a key component of homeostasis, involved in cell signaling, metabolism, and quality control, and they experience functional compromise in metabolic diseases, aging, and neurodegenerative diseases.'], ["Parkinson's disease (PD) and Alzheimer's disease (AD) are common neurodegenerative disorders of the elderly and, therefore, affect a growing number of patients worldwide."], ['Mitochondrial dysfunction is a hallmark of aging and of neurodegenerative diseases.'], ['This is of particular interest for brain diseases, including neurodegenerative disorders and cancer, in which stem cells are exhausted and transformed, respectively.'], ["Alzheimer's disease (AD) is the most widespread neurodegenerative disorder and has caused a major global health concern with the aging of the population."], ['BACKGROUND AND AIMS: Aging becomes a growing global concern with an increased risk of neurodegenerative diseases (NDs) that mainly consist of cognitive decline and Parkinson disease (PD).', 'As the most commonly prescribed antidiabetic drug, metformin has been shown to have inconsistent roles in the incidence of NDs.', 'We performed a systematic review and meta-analysis of observational studies to evaluate the effect of metformin exposure on onset of NDs.', 'METHODS: The observational studies that investigated the associations between metformin and the incidence of NDs were searched in MEDLINE, Embase and Cochrane Library databases.', 'Meta-analysis found there was no significant effect on incidence of all the subtypes of NDs with metformin exposure (OR 1.04, 95% CI 0.92 to 1.17).', 'CONCLUSION: Metformin has failed to demonstrate a beneficial effect on NDs.', 'In light of current results, how metformin would impact NDs, especially the potential risk of PD, needs to be scrutinized.'], ['Theses reviewed in this issue include "Characterization and Purification of Putative Stem Cells from the Adult Murine Pancreas," "Inhibition of TLR4 Minimizes Islet Damage due to Sterile Inflammation and Improves Islet Transplant Outcomes," "Liquefaction of the Brain Following Stroke Shares Multiple Characteristics with Atherosclerosis and Mediates Secondary Neurodegeneration in an Osteopontin-Dependent Mechanism," "Manipulating the Segregation of Human Mitochondrial DNA," "Role of Mitochondria in Plasma Membrane Repair and Pathogenesis of Muscular Dystrophy," and "The Role of Cytosolic Accumulation of Nuclear DNA in Retinal-Pigment Epithelium Dysfunction and Age-Related Macular Degeneration."'], ['Finally, we demonstrate the existence of a conserved pathway in human iPS-derived microglia-like cells, which are central players in neurodegeneration.'], ['Like most neurodegenerative diseases, CTE is diagnosed conclusively by a neuropathological examination of brain tissue.', 'In 2015, using the McKee proposed criteria for the neuropathological diagnosis of CTE, a consensus panel of expert neuropathologists confirmed CTE as a unique neurodegenerative disease with a pathognomonic lesion and published the preliminary NINDS (National Institute of Neurological Disorders and Stroke) criteria for CTE.'], ['Beneficial effects of the combination of both strategies on cognitive function have been described in both ageing adults and patients with neurodegenerative diseases, such as MS.'], ['Age-related macular degeneration (AMD) is a progressive degenerative disease that is the leading cause of vision loss in the elderly population.'], ['INTRODUCTION: Premutation carriers of the FMR1 gene are at risk of developing fragile X-associated tremor/ataxia syndrome (FXTAS), a neurodegenerative disease characterized by motor, cognitive, and psychiatric decline as well as cerebellar and cerebral white matter pathology.', 'Several studies have documented preclinical sensorimotor issues in aging premutation carriers, but the extent to which sensorimotor brain systems are affected and may represent early indicators of atypical neurodegeneration has not been determined.'], ['Efforts to develop an effective treatment have been challenged by the lack of understanding of the pathological mechanisms underlying neurodegeneration.'], ['Reduced BMI1 expression is unique to LOAD compared to familial early-onset AD (EOAD) and other related neurodegenerative disorders; moreover, reduced expression of this single gene is sufficient to reproduce most LOAD pathologies in cellular and animal models.'], ['Backward walking better differentiates fallers from non-fallers in the elderly and other neurodegenerative diseases; therefore, the objective of this study was to examine both forward and backward walking to determine the strongest, unique contributor that differentiates fallers from non-fallers in persons with multiple sclerosis.'], ['Neurodegenerative diseases represent one of the most important public health problems and concerns, as they are a growing cause of mortality and morbidity worldwide, particularly in the elderly.', 'Both In vitro and in vivo studies have more recognized the convenience of natural products in different preclinical models of neurodegenerative disorders.', "Moreover, they are well recognized to participate in an essential position in the prevention of like treatment of different neurodegenerative diseases, like Alzheimer's disease, Parkinson's disease, epilepsy, and additional neuronal disorders."], ["Studies suggest that concussions may be related to increased risk of neurodegenerative diseases, such as Chronic Traumatic Encephalopathy and Alzheimer's Disease."], ["Alzheimer's disease (AD) is a neurodegenerative disorder that is multifactorial in nature."], ['Overall, this essential role of ATXN2L for embryogenesis raises questions about its role in neurodegenerative diseases and neuroprotective therapies.'], ['In humans, as a hormonal regulator, produced in the pineal grand as well in mitochondria, melatonin is involved in different, complex intracellular signaling pathways, with antioxidant and immune stimulating effects, proving to act as a circadian synchronizer, as a preventive and therapeutic agent in many degenerative diseases, and especially in hormone-dependent cancers.', 'Preclinical or clinical studies showed recently the mechanisms involved in regulating the cellular activity, its role in aging and circadian disturbances and impact on degenerative diseases.', 'This overview includes recent and relevant literature data related to the impact of endogenous and exogeneous melatonin on the prevention of cancer progression and treatment of various degenerative diseases.'], ['The syndrome has been reported after surgery on the corpus callosum and with brain tumours, aneurysms, degenerative diseases of the brain and uncommonly with stroke.'], ["BACKGROUND: Parkinson's disease as a common neurodegenerative disease, has been found to be related to inflammation."], ["Alzheimer's disease (AD) is a progressive neurodegenerative disorder that currently has no cure.", 'Identifying biochemical changes associated with neurodegeneration prior to symptom onset, will provide insight into the biological mechanisms associated with neurodegenerative processes, that may also aid in identifying potential drug targets.', 'The current study therefore investigated associations between plasma neurofilament light chain (NF-L), a marker of neurodegeneration, with plasma metabolites that are products of various cellular processes.', 'Metabolites belonging to biogenic amine (creatinine, symmetric dimethylarginine, asymmetric dimethylarginine; ADMA, kynurenine, trans-4-hydroxyproline), amino acid (citrulline, proline, arginine, asparagine, phenylalanine, threonine) and acylcarnitine classes were observed to have positive correlations with plasma NF-L, suggesting a link between neurodegeneration and biological pathways associated with neurotransmitter regulation, nitric oxide homoeostasis, inflammation and mitochondrial function.', 'Additionally, after stratifying participants based on low/high brain amyloid-beta load (Abeta +-) assessed by positron emission tomography, while creatinine, SDMA and citrulline correlated with NF-L in both Abeta- and Abeta+ groups, ADMA, proline, arginine, asparagine, phenylalanine and acylcarnitine species correlated with NF-L only in the Abeta+ group after adjusting for confounding variables, suggesting that the association of these metabolites with neurodegeneration may be relevant to AD-related neuropathology.', 'Metabolites identified to be associated with plasma NF-L may have the potential to serve as prognostic markers for neurodegenerative diseases, however, further studies are required to validate the current findings in an independent cohort, both cross-sectionally and longitudinally.'], ['Differently, motor and cognitive impairment constitute the most common phenotypic expressions of neurodegeneration.', 'Movement disorders are often characterized by cognitive disturbances, and neurodegenerative dementias often exhibit the occurrence of movement disorders.', "In the present review, we critically reappraised the common clinical and pathophysiological aspects of neurodegeneration in both animal models and patients, looking at motricity as a trait d'union over the spectrum of neurodegeneration and focusing on synaptopathy and oscillopathy as the common pathogenic background."], ["Parkinson's disease (PD) is a common neurodegenerative disease."], ['We next examine overlap with 251 brain differentially expressed gene sets from mouse models of AD and other neurodegenerative disorders.'], ['The factors present in all the stages of cell differentiation are able to counteract neurodegeneration, and to regenerate tissues: It has been possible to regenerate hair follicles in many patients with androgenetic alopecia through transdermal administration of stem cell differentiation stage factors (SCDSFs) by means of cryopass-laser.'], ['In the UK and the Westernised countries, most people die aged 80+ from disabling, chronic and degenerative diseases, having spent several years in poor health.'], ['Microglia and central nervous system (CNS)-infiltrating macrophages, collectively called CNS mononuclear phagocytes (CNS-MPs), play central roles in neurological diseases including neurodegeneration and stroke.'], ["Alzheimer's disease (AD) represents a devastating progressive neurodegenerative disease with a complex pathophysiology, affecting millions of people worldwide.", 'Despite the fact that current evidence on the role of epigenetic dysregulation in aging and AD is convincing, the pioneering field of neuroepigenetics is still facing many challenges that need to be addressed to fundamentally increase our understanding about the underlying mechanisms of this neurodegenerative disorder.'], ["Alzheimer's disease is the most common neurodegenerative disorder, and its prevalence increases with age."], ["Nanosized magnetite is a highly toxic material due to its strong ability to generate reactive oxygen species in vivo, and the presence of magnetite NPs in the brain has been linked with aging and neurodegenerative diseases such as Alzheimer's disease."], ['Osteoarthritis (OA) is a degenerative disease affecting the majority of over 65 year old people and characterized by cartilage degeneration, subchondral abnormal changes, and inflammation.'], ['With an aging population that has been increasing in recent years, the need for the development of therapeutic approaches for treatment of neurodegenerative disorders (ND) has increased.', 'ND, which are characterized by the progressive loss of the structure or function of neurons, are often associated with neuronal death.', "Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS), frontotemporal dementia, Huntington's disease, and prion diseases belong to ND which affect enormous numbers of people globally.", 'There are some main possible reasons for failure in the treatment of neurodegenerative diseases such as limitations introduced by the Blood-Brain Barrier (BBB), the Blood-Cerebrospinal Fluid Barrier (BCFB) and P-glycoproteins.', 'Despite numerous papers published in this filed, there are some unsolved issues that need to be addressed for successful treatment of neurodegenerative diseases.'], ['Due to its tropism in the brain, ASX has recently been studied as a putative neuroprotective molecule capable of delaying or preventing brain aging in different experimental models of brain damage or neurodegenerative diseases.'], ['Our findings provide a new set of markers for healthy brain aging and suggest new targets for therapeutic approaches to neurodegenerative diseases.'], ['Recent studies support a role of senescent cells in age-related morbidity, including neurodegenerative diseases, cardiovascular pathologies, cancers, aging-associated nephrological alterations, chronic pulmonary disease and osteoarthritis, indicating that senescent cells could represent an interesting target for therapeutic exploitation across a range of pathophysiological contexts.'], ['Moreover, to assess the balancing between them, the Small World (SW) parameter is employed, evaluating functional coupling in normal brain aging and in pathological conditions including neurodegeneration.'], ['Aging is the strongest risk factor for metabolic, vascular and neurodegenerative diseases.'], ["Thinning of retinal layers, measured using optical coherence tomography (OCT), is associated with some neurodegenerative disorders such as established Alzheimer's disease and multiple sclerosis.", 'The evidence for retinal layer thinning in both mild cognitive impairment (MCI), a precursor of dementia, and delirium, a potential pre-clinical stage of neurodegenerative disorder, is unclear.'], ['Mutations in the ATM gene in humans result in ataxi A-Telangiectasia disease (A-T) characterized by a variety of symptoms with neurodegeneration and premature ageing among them.'], ["BACKGROUND: Alzheimer's disease (AD) is a progressive neurodegenerative disease that affects aging populations."], ['Given the biological anti-oxidant effect of serum urate, the association of gout with neurodegenerative disorders is being actively explored.'], ['Targeting senescent cells by means of removal, modulation of SASP or through cellular reprogramming represents a novel therapeutic avenue for treating cancer- and age-related diseases such as neurodegeneration, pulmonary fibrosis and renal disease.'], ["Alzheimer's disease (AD) is the most common cause of dementia in the elderly, and the underlying molecular mechanisms of this neurodegenerative disorder are still unclear."], ['Vertebral osteoporotic fractures (21.6%), degenerative spinal disorders (20.9%), and osteoarthritis (20.6%) were the most common indications for opioid use.'], ['Evidence is mounting for the central role of mitochondrial dysfunction in several pathologies including metabolic diseases, accelerated ageing, neurodegenerative diseases and in certain xenobiotic-induced organ toxicity.'], ['BACKGROUND: Osteoarthritis represents a kind of chronic and degenerative joint disease characterized by articular cartilage injury and osteoproliferation.'], ['Major depressive disorder (MDD) has been identified as a risk factor or prodrome for neurodegenerative dementias, suggesting neuropathological overlaps and a continuum between MDD and neurodegenerative disorders.'], ["Alzheimer's Disease (AD) is a neurodegenerative disease that causes complications with thinking capability, memory and behavior."], ['Overall, our study provides a molecular framework for understanding the complex interplay between Abeta, aging, and neurodegeneration within the most vulnerable neurons in AD.'], ['The global increase in neurodegenerative disorders is one of the most crucial public health issues.'], ['As ageing is the main risk factor for dementia-related neurodegeneration, changes in the timing or nature of the cellular hallmarks of normal ageing might be key to understanding the events that convert normal ageing into neurodegeneration.', 'However, owing to a lack of evidence, it is not possible to label cellular senescence as a cause or a consequence of neurodegeneration.'], ['BACKGROUND: Mitochondrial dysfunction causes or contributes to a wide variety of pathologies, including neurodegenerative diseases, cancer, metabolic diseases, and aging.'], ['Critically, when seen in isolation, RBD is a highly specific marker of future synucleinopathy: long-term cohort studies indicate that more than 80% of people who develop isolated RBD will go on to develop an alpha-synuclein related neurodegenerative disorder.', 'Recently, the largest ever study of 1280 polysomnographically-diagnosed RBD subjects from 24 International RBD Study Group sleep centres by a single author group, found an overall conversion rate from iRBD to an overt neurodegenerative syndrome of 6.3% per year.', "RBD is therefore common, representative of a large proportion of sporadic disease, and provides a unique window for the study of prodromal neurodegeneration, whether it be Parkinson's or Dementia."], ['Structural Insights provided could open up a novel paradigm of structure-based design of selective allosteric inhibition of Casp6 towards the treatment of neurodegenerative diseases.'], ['BACKGROUND: Current demographic trends point towards an aging society entailing increasing occurrence and burden of neurodegenerative diseases.', 'In this context, understanding physiological aging and its turning point into neurodegeneration is essential for the development of possible biomarkers and future therapeutics of brain disease.', 'CONCLUSIONS: We here describe the study protocol and baseline findings of the SENIOR observational study which aim is the establishment of integrated, multiparametric maps of normal aging and the identification of early biomarkers for neurodegeneration.'], ['METHODS: To assess the clinical utility of salivary Lf for AD diagnosis, we examine the relationship between salivary Lf and cerebral amyloid-beta (Abeta) load using amyloid-Positron-Emission Tomography (PET) neuroimaging, in two different cross-sectional cohorts including patients with different neurodegenerative disorders.'], ['Aging and neurodegeneration have been reported to affect CP morphology and function and increase protein leakage from blood to the CSF.', 'Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease associated with both upper and lower motor neuron loss, as well as altered proteomic and metabolomic signatures in the CSF.'], ["The movement disorder Parkinson's disease (PD) is the second most frequently diagnosed neurodegenerative disease, and is associated with aging, the environment, and genetic factors."], ['OBJECTIVE: To investigate sex differences in late-onset Alzheimer disease (AD) risks by means of multimodality brain biomarkers (beta-amyloid load via 11C-Pittsburgh compound B [PiB] PET, neurodegeneration via 18F-fluorodeoxyglucose [FDG] PET and structural MRI).'], ['White matter abnormalities of the human brain are implicated in typical aging and neurodegenerative diseases.'], ['NAD+ levels decline in the human brain and other organs with age and this is associated with neurodegeneration and other age-related diseases.'], ["Parkinson's disease (PD), a progressive neurodegenerative disorder, is associated with the destruction of dopamine neurons in the substantia nigra (SN) and the formation of Lewy bodies in basal ganglia.", 'Recently, its significance in regulation of some critical brain functions and usefulness in neurodegenerative diseases such as PD has been suggested.'], ['Cellular senescence has causal roles in mediating osteoporosis, frailty, cardiovascular diseases, osteoarthritis, pulmonary fibrosis, renal diseases, neurodegenerative diseases, hepatic steatosis, and metabolic dysfunction.'], ['In a constantly aging population, the prevalence of neurodegenerative disorders is expected to rise.', 'With this approach, a complete histological characterization of all frozen material can be obtained, and omics studies can be performed on histologically well-defined tissues from both hemispheres thus offering a more complete assessment of neurodegenerative disease mechanisms.'], ["BACKGROUND: The progressive aging of the population will dramatically increase the burden of dementia related to Alzheimer's disease (AD) and other neurodegenerative disorders in the future."], ['We propose that drugs that prevent oxoaldehyde stress or excessive ASA oxidation may protect against age-related cataract and neurodegenerative diseases.'], ["Pluripotent Stem Cells [PSCs] are emerging as an excellent cellular source for the treatment of many degenerative diseases such as diabetes, ischemic heart failure, Alzheimer's disease, etc."], ['BACKGROUND AND AIMS: Increasing evidence suggests that inflammation plays an important role in brain aging and neurodegeneration.'], ['We emphasize the role of alpha-synuclein oligomers as a major dysfunctional signal underlining microglial-mediated phenotypic switch and adaptive response contributing to neurodegeneration.'], ['METHODS: Using data from the Chicago Health and Aging Project (CHAP; n = 1,845) and the Rush Memory and Aging Project (MAP; n = 920), we defined a healthy lifestyle score on the basis of nonsmoking, >=150 min/wk moderate/vigorous-intensity physical activity, light to moderate alcohol consumption, high-quality Mediterranean-DASH Diet Intervention for Neurodegenerative Delay diet (upper 40%), and engagement in late-life cognitive activities (upper 40%), giving an overall score ranging from 0 to 5.'], ['Only 38 resources (38/224, 17.0%) were devoted specifically to carers, addressing the management of health disturbances and diseases of the care recipient and focusing primarily on neurodegenerative diseases.'], ["INTRODUCTION: There has been little work on the relationship between sarcopenia, a progressive skeletal muscle disorder, and age-related neurodegenerative diseases such as Parkinson's disease (PD)."], ["Alzheimer's disease is a progressive and fatal neurodegenerative disease affecting 50 million people worldwide, characterized by memory loss and neuronal degeneration."], ['Background: Intervertebral disc (IVD) degeneration is a common degenerative disease that can lead to collapse or herniation of the nucleus pulposus (NP) and result in radiculopathy in patients.'], ['However, the multimodal nature of dance presents challenges to researchers aiming to identify mechanisms involved when dance is used to combat neurodegeneration or support healthy ageing.'], ['LINKAGE TO OTHER MAJOR THEORIES: This hypothesis is in agreement with two physiopathological explanations of the sAD as a downstream process determined by the early lesions of the hypothalamus and autonomic vegetative system (neurodegeneration), or as a consequence of low neuroinflammation and dysimmunity since the early life aggravated in the elderly (immunosenescence).'], ['Aging is a major risk factor for numerous human pathologies, including cardiovascular, metabolic, musculoskeletal, and neurodegenerative conditions and various malignancies.'], ['However, adipokine, such as chemerin is a novel cytokine, which is secreted by adipose tissue, and are thought to be played major roles in various degenerative diseases.'], ["This narrative review aims to address the topic of balance and wireless sensors in several neurological disorders, including Alzheimer's disease, Parkinson's disease, multiple sclerosis, stroke, and other neurodegenerative and acute clinical syndromes."], ['Our findings are among the first empirical evidence to confirm that adaptation capacity, indexed by ANS flexibility, predicts individual differences in learning and associated neuroplasticity beyond individual characteristics (e.g., age, education, neurodegeneration, total training).'], ["Women's brain health is historically understudied, and little is therefore known about the mechanisms underlying epidemiological sex differences in neurodegenerative diseases, and how female-specific factors may influence women's brain health across the lifespan."], ['However, many disorders and syndromes, such as osteoporosis, neurodegenerative disorders, cognitive decline etc., often come with aging.', 'T1-11 could be a potent agent for postponing senility and preventing aging-related neuroinflammation and neurodegeneration.'], ['Additionally, the role of small RNA biogenesis proteins in the pathogenesis of age-related diseases, including cancer, inflammaging, neurodegeneration, cardiovascular, metabolic and immune disorders, has been conclusively evidenced.'], ['Since the ability to regenerate in the adult mammalian central nervous system is very limited, brain trauma and neurodegeneration are often permanent.'], ['BACKGROUND: Neurodegenerative diseases are public health challenges in aging populations.', 'Early identification of people at risk for neurodegeneration might improve targeted treatment.', 'Optical coherence tomography (OCT) measures the thickness of nerve cell layers in the retina, which is an anatomical extension of the brain and might be indicative of common underlying neurodegeneration.', 'CONCLUSIONS: mGCIPL thickness is associated with cognitive and sensorineural function and has the potential as a marker for neurodegeneration in middle-aged adults.'], ['Neurodegeneration is one of the greatest threats to global public health.', "Neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, and Huntington's disease are among the major causes of chronic neurological conditions in the elderly populations.", 'In this context, traditional medicines offer untapped potentials for discovery and translation of novel molecular targets to human neurodegenerative disease research and clinical neurology.', 'This expert review offers a synthesis of the prospects and challenges of harnessing new molecular targets from traditional medicines, with a view to applications for neuroprotection in human neurodegenerative diseases.'], ['Finally, we need to explore treatment of frailty rather than individual manifestations of frailty (e.g., atherosclerosis, neurodegeneration).'], ['Currently, there are no effective therapeutic approaches to treat or slow the progression of chronic neurodegeneration.'], ["Parkinson's disease (PD) is the second most prevalent late-age onset neurodegenerative disorder, affecting 1% of the population after the age of about 60 years old and 4% of those over 80 years old, causing motor impairments and cognitive dysfunction.", 'Increasing evidence indicates that Mediterranean diet (MD) exerts beneficial effects in maintaining health, especially during ageing and by the prevention of neurodegenerative disorders.', 'Our study demonstrates that HD polyphenolic extract treatment has the potential to partly prevent or even treat ageing-related neurodegenerative diseases and ageing itself.'], ['Moreover, pan-neuronal overexpression of Ldh disrupted circadian locomotor activity rhythms and significantly increased brain neurodegeneration.', 'In contrast, reduction of Ldh in neurons delayed age-dependent neurodegeneration.'], ["Rationale: Monoacylglycerol lipase (Mgll), a hydrolase that breaks down the endocannabinoid 2-arachidonoyl glycerol (2-AG) to produce arachidonic acid (ARA), is a potential target for neurodegenerative diseases, such as Alzheimer's disease (AD)."], ["The purpose of our article is to highlight recent findings that relate mitomiRs to neurodegenerative diseases, including Alzheimer's, Parkinson's, and Huntington's.", 'We also discuss the involvement of mitomiRs in regulating the mitochondrial genome in age-related neurodegenerative diseases.'], ["BACKGROUND: Alzheimer's disease (AD) is a progressive neurodegenerative disease in the elderly.", 'MicroRNA (miRNA) miR-212-3p (miR-212) has been reported to dysregulated in many neurodegenerative diseases including AD.'], ['The inverse relationship between oligomeric alpha-syn levels and GCase activity was more evident in brain regions susceptible to neurodegeneration (i.e., the striatum and hippocampus) than those that are less vulnerable (i.e., the cerebellum and occipital cortex).', "Alterations in oligomeric alpha-syns and their association with GCase in aging brains may explain the vulnerability of certain brain regions to neurodegeneration in Parkinson's disease and dementia with Lewy bodies."], ["INTERPRETATION: Our findings further support the promise of plasma NfL as a biomarker of active neurodegeneration in the detection and tracking of Alzheimer's disease and the evaluation of disease-modifying therapies."], ['Neurodegenerative diseases lead to the death of nerve cells in the brain or the spinal cord.', "A wide range of diseases are included within the group of neurodegenerative disorders, with the most common ones being dementia, Alzheimer's, and Parkinson's diseases.", "The link of a polyphenol found in extra virgin olive oil, namely, tyrosol, with the protein tyrosinase, associated to Parkinson's disease is underlined as a paradigm of affiliation between polyphenols and neurodegenerative disorders."], ['This overview summarises the main themes discussed during the 3rd Symposium on "Nutrition for the Ageing Brain: Moving Towards Clinical Applications" held in Madrid in August 2018, enlarged with the current state of knowledge on how nutrition influences healthy ageing and gives recommendations regarding how the critical field of nutrition and neurodegeneration research should move forward into the future.'], ['OBJECTIVE: To determine the prevalence of dysphagia among an older population and patients with stroke, head and neck cancers (HNCs) or neurodegenerative diseases (NDDs) in China, to identify the factors associated with this condition, and to explore the relationship between dysphagia and nutritional status.', 'RESULTS: A total of 5943 persons met the inclusion criteria and 2341 (39.4%) were identified with dysphagia, including the following: 51.14% of patients with stroke, 34.4% in HNCs, 48.3% in NDDs, and 19.2% of otherwise healthy older adults.', 'CONCLUSION: Dysphagia is prevalent in China among older individuals and people who have suffered a stroke, HNCs, or NDDs.'], ['A constellation of peripheral processes, including metabolic and inflammatory changes, are thought to contribute to neurodegeneration.'], ['Purpose: Pain experience due to spinal degenerative disease decreases activity of daily living and quality of life.', 'The present cross-sectional study was aimed at examining the sex-specific impact of pain severity, psychosocial factors, and insomnia on the disability due to chronic pain arising from spinal degenerative disease.', 'The definition of chronic spinal degenerative disease was (1) pain duration >=3 months, (2) findings of nerve root compression on neurological examination and imaging, and (3) localized neck or lower back pain (not widespread, upper or lower limb pain).'], ['Besides the acute respiratory infection, CoVs are neuroinvasive causing additional inflammation and neurodegeneration.', 'We discuss these potential chronic changes to the central nervous system (CNS) in relation to accelerated brain aging and age-related neurodegenerative disorders.'], ['Importantly, an improper DDR can lead to genome instability, premature ageing and human diseases, including cancer as well as neurodegenerative disorders.'], ["Endogenous NAD+ pool is lower in several chronic and degenerative diseases (e.g., cardiovascular diseases, Alzheimer's and Parkinson's diseases, muscular dystrophies), and also in aging."], ['This reduces the buffering capacity of protein network signalling during aging, thereby increasing the risk of neurodegeneration in the brain.'], ['It is unclear whether cerebrospinal fluid (CSF) phosphatidylcholines (PCs) are associated with neuroimaging measures of amyloid deposition and neurodegeneration (glucose metabolism, cortical thickness, and hippocampal volume), cognitive decline, or risk of mild cognitive impairment (MCI) among cognitively unimpaired older adults.', 'This study investigated the associations of 19 individual CSF PC concentrations and their total sum with cross-sectional and longitudinal measures of amyloid deposition and neurodegeneration, global and domain-specific cognitive z-scores, and risk of MCI among 655 cognitively unimpaired participants, mean age of 71 years, enrolled in the Mayo Clinic Study of Aging.'], ['Previous research has suggested associations between hormones adiponectin, ghrelin and leptin and neurodegenerative disease.'], ['Elevated external details are consistently observed in aging and in neurodegenerative diseases.'], ['Finally, in the context of the nonlocal influence of telomeres on pluripotency and stemness, we discuss major opportunities for progress in molecular understanding of aging-related disorders and neurodegenerative diseases.'], ['Sarcopenia is a chronic degenerative neuromuscular disease closely related to cardiomyopathy and chronic heart failure, which influences the production and release of myokines.'], ['CONCLUSIONS: Higher cardiovascular risk burden may predict decline in episodic memory, working memory, and perceptual speed and is associated with neurodegeneration and vascular lesions in the brain.'], ['Decreased levels of Reelin activity have been postulated as a key factor during neurodegeneration in Alzheimer s disease (AD) and in aging.', 'In addition, a compelling analysis of Reelin levels in neurodegenerative diseases other than AD is missing.'], ['Conversely, ferroptosis is associated with aging and neurodegeneration.'], ['Perturbed ubiquitination has been implicated in human diseases ranging from cancer to neurodegenerative diseases.'], ['Though p9 methylation has been studied in healthy human populations and in the context of cancer, it has not yet been analyzed in neurodegenerative disease, where mitochondrial dysfunction is a prominent and early hallmark of disease progression.', 'CONCLUSION: With mitochondrial dysfunction being an established hallmark of neurodegenerative disease pathophysiology, this work sheds light on the potential molecular underpinnings of this dysfunction.'], ["OBJECTIVE: Damage to locus ceruleus neurons could play a part in the pathogenesis of neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease, and multiple sclerosis because of impairment of the blood-brain barrier and enhanced neuroinflammation.", 'Toxic metals, or alterations in essential trace metals within individual locus ceruleus neurons, could be one factor determining the non-random destruction of locus ceruleus neurons in normal aging and neurodegenerative diseases, and subsequently the sites of the widespread multifocal central nervous system pathology in these disorders.'], ['A growing body of literature indicates that mitochondrial DNA mutations play a major role in ageing, metabolic diseases, neurodegenerative diseases, neuromuscular disorders and cancers.'], ['The inflection point in age-related cognitive decline is important for our understanding of the pathophysiology of neurodegenerative diseases and for timing therapeutic interventions.'], ['In the last decade, cellular senescence and the senescence-associated secretory phenotype (SASP) have emerged as central drivers of aging and many chronic diseases, including cancer, neurodegeneration, heart disease and osteoarthritis.'], ['Recently, epigenetic modifications have been shown to play a potential role in neurodegeneration, but the specific involvement of epigenetic signatures landscaped by heterochromatin has not been studied in AD.'], ['Older adults with epilepsy frequently report changes in memory function, with a concern about degenerative disease.'], ['While deamidation has long been recognized as a critical event in human aging and multiple degenerative diseases, research progress in this field has been restricted by the technical challenges associated with studying this DPM in complex biological samples.'], ["Alzheimer's disease, categorized by the piling of amyloid-beta (Abeta), hyperphosphorylated tau, PHFs, NFTs and mTOR hyperactivity, is a neurodegenerative disorder, affecting people across the globe."], ["CNS neurodegeneration and atrophy are now recognized as biomarkers of AD according to the National Institute on Aging-Alzheimer's Association (NIA-AA) criteria and recent evidence shows that these markers are among the earliest signs of prodromal AD, before the appearance of amyloid."], ['More recently, the vascular component of neurodegeneration has come under renewed scrutiny partly due to increased appreciation of the relationship between neurovascular injury, cardiovascular disease, and senescence.', "Cerebral microbleeds (CMBs) are among the smallest lesions of the cerebrum which can be visualized using MRI to indicate blood-brain barrier (BBB) impairment; as such, this class of hemorrhages are important for the evaluation and macroscale detection of geriatric patients' microscale pathologies associated with neurovascular disease and/or neurodegeneration."], ["Persistent inflammation has been identified as a contributor to aging-related neurodegenerative disorders such as Alzheimer's disease."], ["Six databases were searched (years 2008-2019).Inclusion criteria: Randomized controlled trials (RCTs) or cohort studies; people with impaired cognition due to non-degenerative diseases; and evaluation of ICT-based-ATs' effectiveness regarding activity and participation, including prospective memory, execution of tasks and satisfaction with task execution."], ["Parkinson's disease (PD) is one of the most common neurodegenerative diseases."], ['It is a chronic-progressive neuro-degenerative disease, characterized by several motor disorders.'], ['Although normal aging presents an accumulation of copper and iron in the brain, this becomes more relevant in neurodegeneration.'], ['In humans, genetic mutations, pathologies, certain medical treatments, and aging, result in CoQ deficiencies, which are linked to mitochondrial, cardiovascular, and neurodegenerative diseases.'], ['NAD+ is a redox-active metabolite, the depletion of which has been proposed to promote aging and degenerative diseases in rodents.', 'However, whether NAD+ depletion occurs in patients with degenerative disorders and whether NAD+ repletion improves their symptoms has remained open.'], ['It is essential for the maintenance of genome integrity and thus in the prevention of the development of human diseases, including premature ageing, neurodegenerative diseases and cancer.'], ['Although cross-seeding of amyloidogenic proteins (APs), including amyloid beta and alpha-synuclein, may be critical in the co-morbidity of neurodegenerative disorders, the direct interaction of APs with prion protein (PrP), the central molecule involved in the pathogenesis of CJD, is unlikely.'], ['Osteoarthritis (OA) is one of the most common degenerative joint diseases in aging people.'], ['The physiology of circadian rhythm is expansive, and its link to the neurodegeneration is multifactorial.'], ["Alzheimer's disease (AD) is a chronic neurodegenerative disease affecting the elderly."], ["Thus, upregulating Klotho in the brain may lead to novel therapeutics to people suffering or at risk for neurodegenerative diseases such as Alzheimer's, Parkinson's, and amyotrophic lateral sclerosis, and demyelinating diseases such as multiple sclerosis."], ['Neurodegenerative diseases represent a significant unmet medical need in our aging society.', 'Among the challenges faced by those involved in developing therapeutic drugs for neurodegenerative diseases, the syndromes are often complex, and small animal models do not fully recapitulate the unique features of the human nervous system.', 'Here, we will review current applications and potential future directions for iPSC-based neurodegenerative disease models for critical drug screening.'], ['LTL does not change in the context of degenerative disease for these individuals who are biologically younger than the general population.'], ["AIM AND OBJECTIVE: Parkinson's disease (PD) is the second most common neurodegenerative disease."], ["Parkinson's disease (PD) is an aging-related neurodegenerative disorder characterized by progressive motor impairment.The etiology of PD is poorly understood but likely involves both genetic and environmental factors; the management of the disease is still with symptomatic therapy without any interference on the progression of neurodegeneration."], ['Here, we present a short overview on the role of microglia in human neurodegenerative diseases and provide an update on the current model systems to study microglia, including cell lines, iPSC-derived microglia with an emphasis in their transcriptomic profile and integration into 3D brain organoids.', 'We present various strategies to model and study their role in neurodegeneration providing a relevant platform for the development of novel and more effective therapies.'], ['OBJECTIVE: Osteoarthritis (OA) is a common clinical degenerative disease and has a high incidence in the elderly.'], ["Therefore, we suggest that age has a limited influence on neuronal volume variation in these HF regions, which needs to be compared with similar measurements in neurodegenerative disorders such as Alzheimer's."], ['OBJECTIVE: To examine the association of baseline elevated brain amyloid and neurodegeneration with changes in activities of daily living in participants without dementia (ND; i.e., cognitively unimpaired and participants with mild cognitive impairment) at baseline in the population-based Mayo Clinic Study of Aging.'], ['Direct stereotactic implantation of NPCs alleviated the symptoms of ataxia, acting as a neuroprotectant, supporting future clinical applications of these NPCs in the areas of ataxia as well as other neurodegenerative diseases.'], ["BACKGROUND: The National Institute on Aging and Alzheimer's Association proposed an ATN classification system which divided Alzheimer's disease biomarkers into three binary classes: amyloid deposition (A), tauopathy (T), and neurodegeneration or neuronal injury (N)."], ["These roles therefore, indicate that 17beta-HSD10 may be a possible druggable target for neurodegenerative diseases including Alzheimer's disease (AD), and in hormone-dependent cancer."], ['Research in animals and humans has indicated that polyphenols can delay the age-related decline in learning, memory and neurodegenerative diseases.'], ['Growing amounts of evidence from clinical trials suggest that metformin can effectively reduce the risk of many age-related diseases and conditions, including cardiometabolic disorders, neurodegeneration, chronic inflammation and frailty.'], ["Alzheimer's disease (AD) is the most common neurodegenerative disease among the elderly with a progressive decline in cognitive function significantly affecting quality of life."], ["BACKGROUND: Studies link c-Abl activation with the accumulation of pathogenic alpha-synuclein (alphaS) and neurodegeneration in Parkinson's disease (PD)."], ['No specific therapies for other phenotypes (muscular dystrophy, male infertility, hearing loss, neurodegeneration) exist as yet, but their severity often requires supportive medical intervention.'], ['In neurodegenerative diseases and cognitive decline, potential benefits of KD were previously pointed out, but the published evidence remains scarce.'], ["Alzheimer's disease (AD), a progressive neurodegenerative disorder, is characterized clinically by cognitive decline and pathologically by the development of amyloid plaques."], ['Late-onset NPS should raise suspicions of neurodegeneration.'], ['The Biomedical Sciences are now increasingly unraveling the etiopathogenesis of most chronic degenerative diseases; thus, it will be possible to monitor and treat those that most contribute to the increased frailty of each person, which is now referred to with the misnomer "physiological ageing".', 'These concepts are not banal; indeed, they imply that we must try to avoid the causes of alterations that result later in chronic degenerative diseases.'], ['OBJECTIVE: Therapeutic development in progressive multiple sclerosis (PMS) has been hampered by a lack of reliable biomarkers to monitor neurodegeneration.', 'INL and ONL measures may be novel biomarkers of neurodegeneration in PMS that appear to be unaffected by conventional DMTs.'], ['T1rho, a biomarker that varies according to a feature common to each cascade rather than one that is unique to a particular pathology, has the potential to serve as a metric of neuropathology, theoretically providing a measure for assessing pathological status and for monitoring the neurodegeneration trajectory.'], ['Mutations in TWINKLE cause a number of human disorders associated with mitochondrial dysfunction, neurodegeneration and premature ageing.'], ['BACKGROUND: Deterioration of ionized calcium (Ca2+) handling in neurons could lead to neurodegenerative disease.'], ['Most neurodegenerative diseases and in particular those associated with dementia have been defined as proteinopathies due to the presence of intra- and/or extracellular protein aggregates in the brain of affected individuals.'], ['The modulation by hippocampal amyloid suggests that amyloid is a necessary, but not sufficient, process to drive neurodegeneration in memory-related regions.'], ['Indeed, numerous studies have reported that a ketogenic diet or ketone ester administration alleviates symptoms of neurodegenerative diseases, cardiovascular diseases, and cancers.'], ["Studies have shown that imbalance of these metal ions in the brain is closely related to the onset and progression of Alzheimer's disease (AD), the most common neurodegenerative disorder in the elderly."], ['Overall, non-invasive techniques of neurostimulation may represent a valid approach to mitigate cognitive decline associated with aging and neurodegeneration.'], ['Our work uncovers a dedicated chaperone of pTau and suggests NMNAT as a key node between NAD+ metabolism and Tau homeostasis in aging and neurodegeneration.'], ['BACKGROUND: Although ageing and neurodegenerative diseases, including Alzheimer disease, have been associated with olfaction impairment, studies exploring how to ameliorate this impairment are limited.'], ["Alzheimer's disease, Parkinson's disease and multiple sclerosis will be described as typical neurodegenerative diseases.", 'Neuroinflammation and neurodegenerative diseases seem to be a central manifestation of a peripheral perturbation of the immune machinery.'], ["Poor diet quality (DQ) is associated with poor cognition and increased neurodegeneration, including Alzheimer's disease (AD)."], ['Mitochondrial dysfunction has been associated with several human pathological conditions, including cancer, aging, and neurodegenerative diseases.'], ['Sporadic Creutzfeld-Jakob disease (CJD) is a rare neurodegenerative disorder.'], ['METHODS: We conducted a study on 297 cognitively healthy elderly people from the BioFINDER study and created subgroups excluding people with signs of underlying neuropathology, i.e., abnormal cerebrospinal fluid [CSF] beta-amyloid or phosphorylated tau, CSF neurofilament light (neurodegeneration), or cerebrovascular pathology.', 'Future studies need to investigate if there is a genuine effect of healthy aging on cognitive tests or if this age effect is a proxy for higher prevalence of preclinical neurodegenerative diseases.'], ['Mutations in LMNA cause degenerative disorders including the premature aging disorder Hutchinson-Gilford progeria, but the mechanisms are unknown.'], ['Proteostasis failure worsens with aging and is considered a cause of and a therapeutic target for age-related diseases including neurodegenerative disorders.'], ['Our rationale was to conduct a retrospective study comparing 3 123I-N-omega-fluoropropyl-2beta-carbomethoxy-3beta-(4-iodophenyl)nortropane (123I-FP-CIT) SPECT quantitative methods in patients with neurodegenerative syndromes as referenced to neuropathologic findings.', 'Methods: 123I-FP-CIT-SPECT and neuropathologic findings among patients with neurodegenerative syndromes from the Mayo Alzheimer Disease Research Center and Mayo Clinic Study of Aging were examined.'], ['The roles of MST1 and MST2 in neurological disorders, including brain tumors, cerebrovascular diseases, neurodegenerative disorders, and neuromuscular disorders, are then presented.'], ['Our results indicate that fine tuning of HSP27 concentration could be used as a strategy for cancer therapy, and also for improving neuronal survival in neurodegenerative diseases.'], ['One of the characteristics of the cerebral aging process is the presence of chronic inflammation through glial cells, which is particularly significant in neurodegeneration.', 'These results suggest that AHR participates in the aging process, and probably in the development of neurodegenerative diseases like AD.'], ['BACKGROUND: Brain volume loss measured from magnetic resonance imaging (MRI) is a marker of neurodegeneration and predictor of disability progression in MS, and is commonly used to assess drug efficacy at the group level in clinical trials.', 'GOAL: To understand the relative contributions of neurodegeneration vs. physiological and technical sources of variability to measurements of brain volume loss in individuals.'], ['Next, we consider the biological mechanisms by which these strategies may act by taking into account the main pathways implicated in the development and progression of dementia: neurodegeneration, brain resilience, vascular damage, neuroinflammation, and oxidative stress.'], ['The development of safe and effective treatments for age-associated neurodegenerative disorders is an on-going challenge faced by the scientific field.', 'There are unique challenges in the development of representative laboratory models of neurodegenerative diseases, including the complexity of the human brain, the cumulative and variable contributions of genetic and environmental factors over the course of a lifetime, inability to culture human primary neurons, and critical central nervous system differences between small animal models and humans.', 'While traditional rodent models have advanced our understanding of neurodegenerative disease mechanisms, key divergences such as the species-specific genetic background can limit the application of animal models in many cases.', 'Here we review in vitro human neuronal systems that employ stem cell and reprogramming technology and their application to a range of neurodegenerative diseases.'], ['Additionally, a nematode (Caenorhabditis elegans) model, previously used for investigating the mechanisms of processes such as aging, neurodegeneration, oxidative stress and inflammation, is presented as an emerging approach for the study of polyphenols interacting gut microbiota.'], ['Characterizing the effects of obstructive sleep apnea (OSA) on the aging brain could be key in our understanding of neurodegeneration in this population.'], ['Voice changes caused by natural aging and neurodegenerative diseases are prevalent in the aging population and diminish quality of life.'], ['The studies report DNAm-MRI associations for: neurodevelopment and neurodevelopmental disorders; major depression and suicidality; alcohol use disorder; schizophrenia and psychosis; ageing, stroke, ataxia and neurodegeneration; post-traumatic stress disorder; and socio-emotional processing.'], ['The role protein aggregates play in the pathogenesis of neurodegenerative diseases has been a question since their initial observation.'], ["BACKGROUND: Cerebrospinal fluid tau and neurofilament light (NfL) are two biomarkers of neurodegeneration in Alzheimer's disease.", 'Most studies use a global cognitive composite as the primary outcome, and it is unknown if critical cognitive domain scores are similarly sensitive to rates of decline due to neurodegeneration.'], ["BACKGROUND: Subclinical cardiac dysfunction is associated with decreased cerebral blood flow, placing the aging brain at risk for Alzheimer's disease (AD) pathology and neurodegeneration.", 'OBJECTIVE: This study investigates the association between subclinical cardiac dysfunction, measured by left ventricular ejection fraction (LVEF), and cerebrospinal fluid (CSF) biomarkers of AD and neurodegeneration.', 'CONCLUSIONS: Among cognitively normal older adults, subclinically lower LVEF relates to greater molecular evidence of tau phosphorylation and neurodegeneration.'], ['METHODS: Older persons without dementia at study enrollment (n = 1,010) had annual cognitive testing for up to 24 years (mean = 9.9 years, standard deviation = 5.0), died, and underwent a neuropathologic examination to quantify 9 postmortem markers of common neurodegenerative and cerebrovascular conditions.'], ["Mitochondrial DNA (mtDNA) mutations are considered a possible cause and this mechanism might be shared with the aging process and with other age-related neurodegenerative disorders such as Alzheimer's disease (AD)."], ['This is significant because (i) peroxisomes are important for the innate immune response and (ii) loss of peroxisome function is associated with cellular aging and neurodegeneration.'], ["BACKGROUND: Alzheimer's Disease (AD) is a progressive neurodegenerative disease that threatens the health of the elderly."], ['Performance declines in these dual-tasks may be associated with early signs of neurodegenerative disease and increased risk of falls.'], ["Neurodegenerative diseases, namely Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis, Huntington's disease, and multiple sclerosis are becoming one of the main health concerns due to the increasing aging of the world's population."], ["Alzheimer's disease (AD) is the most common type of neurodegenerative disease."], ['The immune system contributes to neurodegenerative pathologies.'], ['Introduction: Age-related Macular Degeneration (AMD), a retinal neurodegenerative disease is the most common cause of blindness among the elderly in developed countries.'], ["Induced pluripotent stem-cell-based models enable investigation of pathomechanisms in disease-relevant human brain cell types and therefore offer great potential for mechanistic and translational studies on neurodegenerative disorders, such as Alzheimer's disease (AD).", 'While current AD models allow analysis of early disease phenotypes including Abeta accumulation and Tau hyperphosphorylation, they still fail to fully recapitulate later hallmarks such as protein aggregation and neurodegeneration.'], ['In this study, we summarized the role of exosomal-Nrf2 in different age-related diseases, including diabetic foot ulcers, atherosclerosis, chronic heart failure, reproductive cell failures, and neurodegenerative diseases.'], ['Aging is a major cause of many degenerative diseases.'], ["Alzheimer's disease (AD) is a neurodegenerative disease that mainly occurs in old age and involves progressive cognitive impairment."], ['Increasing evidence suggests that sleep problems are not only a consequence of age-related processes, but may independently contribute to developing vascular or neurodegenerative brain disease.'], ['However, as the population ages, there is also an exponential risk to live into the ages where the brain-related frailties and neurodegenerative diseases develop.', "Recent Advances: It is of utmost importance to clarify the influence of diabetes-related metabolic features on brain health and the mechanisms underlying the increased likelihood of developing neurodegenerative diseases, in particular Alzheimer's disease.", 'On this basis, strategies settled to counteract diabetes-induced neurodegeneration encompassing mitochondrial dysfunction, redox status imbalance, and/or insulin dysregulation seem worth to follow.'], ["The brain is highly enriched in lipids, and disruption of lipid homeostasis is related to neurologic disorders as well as neurodegenerative diseases such as Alzheimer's disease (AD)."], ['BACKGROUND: Genetic polymorphisms like apolipoprotein E (APOE) and microtubule-associated protein tau (MAPT) genes increase the risk of neurodegeneration.', 'APOE4 allele may be a risk factor for tau accumulation in former contact sports athletes at high risk of neurodegeneration.', 'FUNDING: Toronto General and Western Hospital Foundations; Weston Brain Institute; Canadian Consortium on Neurodegeneration in ageing; Krembil Research Institute.'], ['Here we examined the associations of moderate alcohol intake with in vivo AD pathologies, including cerebral Abeta deposition, neurodegeneration of AD-signature regions, and cerebral white matter hyperintensities (WMHs) in the living human brain.', 'Additionally, alcohol intake was not related to neurodegeneration of AD-signature regions or cerebral WMH volume.', 'Moderate lifetime alcohol intake may have a beneficial influence on AD by reducing pathological amyloid deposition rather than amyloid-independent neurodegeneration or cerebrovascular injury.'], ['Aging is a major risk factor for the development of neurodegenerative diseases.', "Alzheimer's disease and other neurodegenerative diseases are characterized by abnormal and prominent protein aggregation in the brain, partially due to deficiency in protein clearance.", 'It has been proposed that alterations in microglia phagocytosis and debris clearance hasten the onset of neurodegeneration.'], ['Dysfunction of multiple components of the BBB occurs in aging, inflammatory diseases, traumatic brain injury (TBI, severe or mild repetitive), and in chronic degenerative dementing disorders for which aging, inflammation, and TBI are considered risk factors.', 'BBB permeability changes after TBI result in leakage of serum proteins, influx of immune cells, perivascular inflammation, as well as impairment of efflux transporter systems and accumulation of aggregation-prone molecules involved in hallmark pathologies of neurodegenerative diseases with dementia.', "The current review focusses on pathological mechanisms shared between TBI and neurodegenerative disorders characterized by accumulation of pathological protein aggregates, such as Alzheimer's disease and chronic traumatic encephalopathy."], ['This study aimed at investigating the overlap between sarcopenia and neurodegeneration, as reflected by a low number of motor neurons in patients with Parkinsonian syndromes (PS).', 'The pathologically low MUNIX values found in 75% of our sarcopenic iPD patients provides further support for the existence of a neurodegenerative overlap syndrome with a reduced number of MUs potentially leading to sarcopenia.'], ['Comprehension of the mechanisms of neurogenesis regulation is essential for the development of new therapeutic approaches for currently incurable neurodegenerative diseases and neuroblastomas.'], ['Aim: Globally, neurodegeneration accounts for significant morbidity and mortality among the elderly.', "Millions of people are afflicted with neurodegenerative diseases, with the most notable cases attributed to Alzheimer's, Huntington's, amyotrophic lateral sclerosis and Parkinson's diseases.", 'Sensitive assays that can detect proteopathic anomalies indicative of early neurodegeneration have remained elusive.', 'Conclusion: In the current study, we evaluated single molecule array technology and report specifications to quantitate neurofilament light chain, a bona-fide biomarker for neurodegeneration.'], ['AD considered as an irreversible neurodegenerative disorder with progressive memory impairment moreover cognitive functions, while MCI would be considered as a transitional phase amongst age-related cognitive weakening.'], ['Recent reports highlight regulatory functions of long noncoding RNAs (lncRNAs) in neurodegeneration and aging, but biomedical implications remain limited.', "LINC-PINT also accumulated in several brain regions of Alzheimer's and Huntington's disease patients and decreased with healthy brain aging, suggesting a general role in aging and neurodegeneration for this lncRNA.", 'RNAi-mediated depletion of LINC-PINT exacerbated the death of cultured N2A and SH-SY5Y cells exposed to oxidative stress, highlighting a previously undiscovered neuroprotective role for this tumor-inducible lncRNA in the brains of patients with neurodegenerative disorders.'], ['Diet scores were computed using a validated food frequency questionnaire for the Dietary Approaches to Stop Hypertension (DASH) diet, Mediterranean diet, Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) diet, and Western diets.'], ['Osteoporosis is a degenerative disease that threatens bone health of the elderly (especially postmenopausal women).'], ['Alzheimer disease (AD) is a chronic neurodegenerative disease with a multitude of contributing genetic factors, many of which are related to inflammation.'], ['Changes in human gait resulting from ageing or neurodegenerative diseases are multifactorial.'], ['PURPOSE OF REVIEW: Cognitive decline because of aging and neurodegeneration has become increasingly prevalent.', 'Additional research with sound methodology including sufficient sample sizes, active control groups and meaningful outcome measures of everyday function is needed to elucidate the potential of serious video games and virtual reality in multifactorial neurorehabilitation of cognitive decline in aging and neurodegeneration.'], ['Behavioral performance on these tasks rely on the integrity of the hippocampus and surrounding circuitry, which are brain regions known to be adversely affected in aging and neurodegenerative disorders.'], ['The increasing extension in life expectancy of human beings in developed countries is accompanied by a progressively greater rate of degenerative diseases associated with lifestyle and aging, most of which are still waiting for effective, not merely symptomatic, therapies.', "In light of the results of these trials, recent research has sought to provide information on the biochemical, molecular, epigenetic, and cell biology modifications by plant polyphenols in cell, organismal, animal, and human models of cancer, metabolic, and neurodegenerative pathologies, notably Alzheimer's and Parkinson disease."], ['Our present understanding of neurodegenerative diseases points towards advanced neuronal age as a prerequisite for the development of these disorders.'], ['Furthermore, AV integrative training can serve as an alternative non-pharmacological intervention for combating neurodegeneration in older adults.'], ['Inflammation is associated with increased risk for chronic degenerative diseases, as well as age-related functional declines across many systems and tissues.'], ['METHODS: Fifty-eight patients with OD caused by aging, stroke, or neurodegenerative disease were included in a three-arm, quadruple-blind, randomized clinical trial (NCT02193438).'], ['PATIENTS AND METHODS: 854 individuals in the Arizona Study of Aging and Neurodegenerative Disorders (AZSAND) had subject as well as informant-completed ESS completed within one year of a movement disorder exam and cognitive assessment.'], ['Mesial temporal lobe (MTL) is prominently affected in normal aging and associated with neurodegeneration in AD.'], ["BACKGROUND: Parkinson's disease (PD) is the second most common neurodegenerative disease of the elderly.", 'Considering the intrinsic properties of cell-penetrating peptides (CPPs) for mediating drug delivery of neurotherapeutics across the blood brain barrier (BBB), these might open novel opportunities for the development of new solutions for the treatment of brain-related aspects of PD and other neurodegenerative disorders.'], ["Bioenergetic crisis and chronic low-grade inflammation are hallmarks of brain aging and menopause and have been implicated as a unifying factor causally connecting genetic risk factors for Alzheimer's disease and other neurodegenerative diseases.", 'These dynamic systems of biology are relevant to multiple age-associated neurodegenerative diseases and provide a therapeutic framework for prevention and delay of neurodegenerative diseases of aging.', 'We further discuss a precision hormone replacement therapy approach to target symptom profiles during endocrine and chronological aging to reduce risk for age-related neurodegenerative diseases.'], ["Parkinson's disease (PD) is a neurodegenerative disorder that results in the death of dopaminergic neurons within the substantia nigra pars compacta and the reduction in dopaminergic control over striatal output neurons, leading to a movement disorder most commonly characterized by akinesia or bradykinesia, rigidity and tremor."], ['An unbalanced or dysregulated inflammasome is associated with infectious, inflammatory, and neurodegenerative diseases.'], ['Cell senescence is one of the most important processes determining cell fate and is involved in many pathophysiological conditions, including cancer, neurodegenerative diseases, and other aging-associated diseases.'], ["Parkinson's disease (PD) is a progressive degenerative nervous system disorder and is the second most common neurodegenerative disorder in the elderly population.", 'Understanding this putative pathogenic loop could provide insight into the means by which neurodegeneration progresses in PD, and it may offer possible novel therapeutic strategies.'], ["Recurrent reactivation of HSV1 may lead to neurodegeneration and Alzheimer's disease (AD) pathology."], ['Introduction: Neurodegenerative diseases are those wherein the neurons in the brain or peripheral nervous system lose their function, eventually culminating in neuronal death.', 'As neurotrophic factors possess imperative roles in protecting the neurons and restoring their functionality, design of different modalities to deliver them to the brain would significantly enhance the therapeutic benefits.Areas covered: This review covers the various mechanisms of neurodegeneration, its molecular link with aging, different neurotrophic factor classes and their potentials, current treatment strategies, the challenges associated with the delivery of neurotrophic factors, administration routes, design of different delivery vehicle design, alternative modalities of delivery, and the clinical translational challenges of these strategies.Expert opinion: A deeper molecular level understanding about the complexity of neurodegeneration, discovery of potential biomarkers, which helps identifying the right targets, finding the accurate animal model completely recapitulating the human scenario, and a validated design of clinical trials would immensely help in overcoming the present challenges.'], ['To address this issue, the present study employed voxel-based morphometry in a region of interest-based design to determine the extent to which gray matter volumes of core olfactory and memory areas are associated with olfactory memory performance in an aging population free from neurodegenerative disease.'], ['Finally, we discuss the current evidence implicating these processes in age-related human pathologies, such as neurodegenerative or cardio-metabolic diseases.'], ['In clinical practice, the quality of polysomnographic recordings in children and patients with neurodegenerative diseases may be affected by sensor displacement and diminished total sleep time due to stress during the recording.'], ['Taken together with our previous results, the current study provides a potential mechanism to rationalize enhancement of the TDP-43 cytotoxicity by D169G and highlights again the key roles of ATP in neurodegenerative diseases and ageing.'], ['The objective of this study is to determine time-dependent trends in patient outcomes following ACDF for degenerative disease from 2006 to 2016.'], ['CONCLUSIONS: Depression may be an independent factor representing early neurodegeneration in elder patients with MCI.'], ['Ventricles of the human brain enlarge with aging, neurodegenerative diseases, intrinsic, and extrinsic pathologies.'], ['Studies have shown promising results of nutraceuticals to treat several diseases, such as cancer, neurodegenerative diseases, cardiovascular diseases, etc.'], ['We should remain alert to the fact that even schizophrenic patients can contract neurodegenerative diseases as a dual diagnosis in their clinical course and that they can show complicated symptoms.'], ['This proof of principle has value for personalized muscle assessment in pain, injury, neurological conditions, neuropathies, myopathies and ageing.'], ['Although alterations in the sympathetic nervous system (SNS) with age have been reported, and serious degenerative diseases of the autonomic nervous system such as multiple system atrophy are more likely to strike older people, connections between dysregulated adrenergic receptors and age-associated diseases and phenotypes have not been well studied.'], ['Patient stratification is critical for the sensitivity of clinical trials at early stages of neurodegenerative disorders.'], ['Atypical iron concentration in the basal ganglia is associated with neurodegenerative disorders in aging and cognitive deficits.', 'Atypical basal ganglia tissue iron levels have been linked to impaired cognition in iron deficient children and adults with neurodegenerative disorders.'], ["Alzheimer's disease (AD) is a neurodegenerative disorder characterized by a progressive and irreversible cognitive decline."], ['INTRODUCTION: Advancing age is a major risk factor for a range of diseases such as, cardiovascular disease, diabetes, cancer and neurodegenerative diseases.'], ['Aging-associated neurodegenerative diseases, which are characterized by progressive neuronal death and synapses loss in human brain, are rapidly growing affecting millions of people globally.', "Alzheimer's is the most common neurodegenerative disease and it can be caused by genetic and environmental risk factors."], ['A number of human diseases, particularly neurodegenerative disorders, have been linked to the dysregulation of mitophagy.'], ['Cockayne Syndrome (CS) is a rare neurodegenerative disease characterized by short stature, accelerated aging and short lifespan.'], ['The significant slowing of gait speed while texting from middle age may be a marker of neurodegeneration, a cohort effect, or an appropriate compensatory response to reduce the risk of injury.'], ['Microglia become progressively activated and seemingly dysfunctional with age, and genetic studies have linked these cells to the pathogenesis of a growing number of neurodegenerative diseases.', 'An unbiased CRISPR-Cas9 screen identified genetic modifiers of lipid droplet formation; surprisingly, variants of several of these genes, including progranulin (GRN), are causes of autosomal-dominant forms of human neurodegenerative diseases.', 'We therefore propose that LDAM contribute to age-related and genetic forms of neurodegeneration.'], ["Using established CSF biomarkers, subjects were classified according to the National Institute on Aging-Alzheimer's Association research framework, which groups markers into those of amyloid-beta deposition (A), tau pathology (T), and neurodegeneration (N)."], ['Age-associated decline in NAD+ is implicated as a driving factor in several categories of age-associated disease, including metabolic and neurodegenerative disease, as well as deficiency in the mechanisms of cellular defense against oxidative stress.'], ['This syndrome is associated risk of postoperative delirium and neurological deterioration.'], ['Our data suggest that these generic compounds can plausibly be used for the treatment of various neurodegenerative diseases occurring due to Hirano body formation in brain cells.Communicated by Ramaswamy H. Sarma.'], ['The senescence-associated secretory phenotype (SASP) has recently emerged as a driver of and promising therapeutic target for multiple age-related conditions, ranging from neurodegeneration to cancer.'], ['BACKGROUND: How cerebrovascular disease and neurodegeneration affect each other to impact cognition is not yet known.'], ["Given the pathway's central role in maintaining cellular and physiological homeostasis, dysregulation of mTOR signalling has been implicated in metabolic disorders, neurodegeneration, cancer and ageing."], ["It is estimated that the global prevalence of dementia will rise as high as 24 million and predicted to be double in every 20 years which is attributed to the fact that the ageing population is increasing and so more individuals are at risk of developing neurodegenerative diseases like Alzheimer's."], ['The global burden of neurodegenerative diseases is alarmingly increasing in parallel to the aging of population.', 'Although the molecular mechanisms leading to neurodegeneration are not completely understood, excitotoxicity, defined as the injury and death of neurons due to excessive or prolonged exposure to excitatory amino acids, has been shown to play a pivotal role.', "Despite the anti-excitotoxic drug memantine has shown modest beneficial effects in some patients with dementia, to date, there is no effective treatment capable of halting or curing neurodegenerative diseases such as Alzheimer's disease, Parkinson disease, Huntington's disease or amyotrophic lateral sclerosis.", 'Moreover, we provide a comprehensive and updated state of the art of preclinical and clinical investigations targeting excitotoxic- related mechanisms in order to provide an effective treatment against neurodegeneration.'], ['Interestingly, mitochondrial sirtuin 3 (SIRT3) plays a major role in maintaining mitochondrial function and preventing oxidative stress, and is downregulated in aging and age-associated diseases such as neurodegenerative disorders.'], ['We have found that XFG cells display defects in lysosomes, microtubules, autophagy, and mitochondria resembling defects found in cells from age-related syndromes, such as the main neurodegenerative diseases.'], ['Low levels of Klotho occur in neurodegenerative diseases, kidney disease and many cancers.'], ['Due to their impact on neurodegeneration, we sought to explore neuropsychological profile, cognitive reserve and emotional distress in patients with severe obesity.'], ['Deficiencies in such systems lead to mitochondrial dysfunction, which is a hallmark of aging and many human diseases, such as neurodegenerative diseases, cardiovascular diseases, and cancer.'], ['Mitophagy efficiency decreases with age leading to accumulation of dysfunctional mitochondria enhancing the severity of age-related disorders including neurodegenerative diseases, inflammatory diseases, cancer, diabetes and many more.'], ["Alzheimer's disease (AD) is an ageing-related neurodegenerative disease characterized and diagnosed by deposition of insoluble amyloid-beta (Abeta) plaques in the brain."], ["Here, we summarize current understanding of functional involvement of microglial cells in the most common neurodegenerative disease to affect humans, which is sporadic or late-onset Alzheimer's disease (LOAD).", 'We have demonstrated an in situ correlation between microglial dystrophy and presence of NFD suggesting that neurodegeneration is secondary to aging-related microglial deterioration, a concept founded on the notion that proper neuronal function is dependent on presence of healthy microglia.'], ['Background: Lumbar disc herniation into the dural space is a very rare phenomenon of degenerative lumbar lesions in the elderly population, and its potential pathogenesis and natural course remain unclear.'], ['Recent studies have shown that raising intracellular NAD+ levels represents a promising therapeutic strategy for age-associated degenerative diseases in general and to extend lifespan in small animal models.'], ['This study protocol focuses on the pilot study, which will be conducted by the German Center for Neurodegenerative Diseases (DZNE) (site Witten).'], ['Previous studies in rodents indicate that aging along with neurodegenerative diseases may promote a proinflammatory state and leads to the development of gliosis in the aged brains.'], ['Here, we review the recent advances in the role of delta-secretase in neurodegenerative diseases, with a focus on its biochemical properties and the transcriptional and posttranslational regulation of its activity, and discuss the clinical implications of delta-secretase as a diagnostic biomarker and therapeutic target for neurodegenerative diseases.'], ["BACKGROUND: Alzheimer's disease, the most common cause of dementia among the elderly, is a progressive and irreversible neurodegenerative disease."], ['Conclusions Preexisting cognitive impairment in patients with atrial fibrillation-associated ischemic stroke or transient ischemic attack is common, and associated with imaging markers of cerebral small vessel disease and neurodegeneration, as well as with longer-term functional outcome.'], ['In this review we will discuss recent evidence about the organization of SVZ and hippocampal neurogenic niches, and will report on how human adult neurogenesis may contribute to disease and appears to respond to neurodegeneration.'], ['Osteoarthritis (OA) is a degenerative articular disorder manifested by cartilage destruction, subchondral sclerosis, osteophytes, and synovitis, resulting in chronic joint pain and physical disability in the elderly.'], ["Alzheimer's disease (AD), the leading cause of dementia in the elderly, is a neurodegenerative disorder marked by progressive impairment of cognitive ability."], ['The most represented causes of mortality were similar in the first and in the subsequent period after admission: cardio-cerebrovascular diseases, neurodegenerative diseases, respiratory diseases, and infections.'], ['However, only recently, it has been acknowledged that PA can reverse at least some of the unwanted effects of a sedentary lifestyle, contributing to the treatment of pathologies such as hypertension and diabetes, to the delay of aging and neurodegeneration, and even to the improvement of immunity and cognitive processes.'], ['CONCLUSION: Comorbidity of cerebrovascular disease and Abeta was associated with cognitive decline and neurodegeneration.'], ["Alzheimer's disease (AD) is a devastating neurodegenerative disorder, neuropathologically characterized by hyperphosphorylation of tau and formation of amyloid plaques."], ['Sex-depended differences with regard to glutathione and its biology have also been reported for a number of human pathologies and diseases such as neurodegeneration, cardiovascular diseases and metabolic disorders.'], ['In some cases, several studies have independently found corroborating evidence for this mechanism in the same or related sets of diseases including cancer and neurodegenerative diseases.'], ["Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by lower DHA levels in blood lipids."], ["Consequently, proteins with incorrect conformations are prone to aggregate and accumulate in cells, and this aberrant aggregation of misfolded proteins may trigger various neurodegenerative diseases, such as Parkinson's disease.", 'These results highlight the possibility of using Hsp60 AD as a method of prevention and treatment of neurodegenerative diseases.'], ['Sedentary aging is often characterized by physical dysfunction and chronic degenerative diseases.'], ['Alzheimer disease (AD) is the most common neurodegenerative brain disease that causes cognitive impairment in the elderly.'], ['With an ageing population comes an inevitable increase in the prevalence of age-associated neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS), a relentlessly progressive and universally fatal disease characterized by the degeneration of upper and lower motor neurons within the brain and spinal cord.'], ['The prevalence and the incidence of epilepsy are slightly higher in men compared to women and tend to peak in the elderly, reflecting the higher frequency of stroke, neurodegenerative diseases, and tumors in this age-group.'], ['CONTENT: We describe the following: (a) clinical utility of AD biomarkers; (b) measurement challenges, including development of mass spectrometry-based reference methods and automated immunoassays; (c) development of "appropriate use criteria" (AUC) guidelines for safe/appropriate use of CSF testing for diagnosis of AD developed by neurologists, a neuroethicist, and laboratorians; (d) a framework, sponsored by the National Institute of Aging-Alzheimer\'s Association (NIA-AA), that defines AD on the basis of CSF and imaging methods for detecting amyloid plaque burden, tau tangle pathology, and neurodegeneration.'], ['In contrast to the idea that HVL occurs in late phases of neurodegeneration, recent contributions indicate that it might occur before abnormal amyloid PET occurrence in elderly subjects and that its severity could be only marginally related to APOE variants.'], ['We postulate that epigenetic factors contribute to the observed variability in intellectual disability, as well as at the level of neurodegeneration seen in T21 individuals.'], ['Aging is the most important single risk factor for many chronic diseases such as cancer, metabolic syndrome, and neurodegenerative disorders.'], ['Glaucoma is a neurodegenerative disease characterised by progressive damage to the retinal ganglion cells (RGCs), the output neurons of the retina.'], ['Vascular degenerative disorders of posterior eye are the vision threatening disorders, involving inflammation as one of the main pathological mechanisms.'], ['Whether this reported disparity is associated with a differential level of neurodegeneration and disease stage or with underlying mechanisms separate from amyloid or tau is unclear.', 'Conclusions and Relevance: This study found that African American individuals had lower levels of tau-based biomarkers that were not likely explained by the degree of disease stage or neurodegeneration reflected by hippocampal volumes.'], ['Chronic inflammation, the principle hallmark of PD, forms the basis of neurodegeneration.', 'During the prodromal/asymptomatic stage of age-associated neurodegenerative diseases (i.e., PD and AD), chronic neuroinflammation may act silently as the driver of neuronal dysfunction.', 'Though research has provided an insight over age-related neurodegeneration in PD, elaborative role of NF-kappaB in neuroinflammation is yet to be completely understood and thus requires more investigation.', 'Polyphenols, a group of naturally occurring compound in medicinal plants, have gained attention because of their anti-oxidative and anti-neuroinflammatory properties in neurodegenerative diseases.'], ['Alzheimer disease (AD) is a neurodegenerative disorder characterized pathologically by the accumulation of amyloid-beta (Abeta) plaques and tau neurofibrillary tangles (NFTs).'], ['Neuroinflammation may be a key factor in brain atrophy in aging and age-related neurodegenerative disease.', 'This suggests a link between neuroinflammation, neurodegeneration, and amyloid-independent tauopathy.'], ['Aging is an important risk factor for several human diseases such as cancer, cardiovascular disease and neurodegenerative disorders, resulting from a combination of genetic and environmental factors (e.g., diet, smoking, obesity and stress), which, at molecular level, cause changes in gene expression underlying the decline of physiological function.'], ['Current research begins to mark a new perspective that recognizes the need to establish a preventive strategy for degenerative diseases.'], ['Numerous cellular and animal model studies indicate that an unbalance in p53 isoform expression in specific cell types causes age-related disorders such as cancer, premature ageing, and degenerative diseases.'], ['Reactive oxygen/nitrogen species generated in the human body can cause oxidative damage associated with many degenerative diseases such as atherosclerosis, dementia, coronary heart diseases, aging, and cancer.'], ['Many researchers are actively exploring the relationship between non-selective and selective autophagy and various pathophysiological states in humans, and are studying the molecular mechanisms underlying autophagy regulation in various biological conditions, including cancer, neurodegenerative diseases, cardiovascular diseases, immune responses, development and ageing.'], ['CONCLUSIONS: Quadrant-specific associations exist between RNFL thickness and brain regions vulnerable to aging or neurodegeneration in older adults with normal cognition.', 'These findings would promote further investigations into using RNFL as a noninvasive and less expensive biomarker of neurocognitive aging and AD-related neurodegeneration.'], ['At times of an aging population and increasing prevalence of neurodegenerative disorders, effective medical treatments remain limited.', 'Neuromodulation may possibly have beneficial effects on course of different neurodegenerative disorders compared to medical therapy alone.', "This article is part of the special issue entitled 'The Quest for Disease-Modifying Therapies for Neurodegenerative Disorders'."], ['Importance: Alzheimer disease (AD) is a neurodegenerative disorder characterized by cognitive deterioration and impaired activities of daily living.'], ["BACKGROUND: Alzheimer's disease (AD) is a heterogeneous neurodegenerative disease."], ["Accelerated bone loss is closely associated with Alzheimer's disease (AD), but the relationship between bone mineral density (BMD) and imaging markers of neurodegeneration remains uncertain.", 'These imaging data suggest that osteopenia may contribute to neurodegeneration of a brain network hub associated with AD.'], ['AGEs are strongly associated with aging-related diseases, including cancer, neurodegenerative diseases, and diabetes.'], ["Parkinson's disease (PD) is the second most prevalent neurodegenerative disease in the elderly people."], ['Neuropsychological assessment plays a prominent role in the evaluation and care of patients with neurodegenerative diseases throughout the dynamic course of disease.'], ['A combination of detailed history and examination often will suggest a likely underlying neurodegenerative disorder and guide further diagnostic workup to establish a specific diagnosis.'], ["The combination of massive investment in dementia/Alzheimer's research in the past decade, widespread awareness among researchers and trainees of the opportunities to do research in age-related diseases, and the need for further knowledge of neurodegenerative diseases led to a broad expansion of research efforts."], ['Patients with mild cognitive impairment and dementia have more severe sleep problems, and disturbed sleep and sleep disorders contribute to earlier onset and more rapid progression of neurodegenerative disorders.'], ['This is problematic when, with innovative technology available in so many aspects of life, modern societies expect to have effective treatments for neurodegenerative disorders and mental health conditions that provide something beyond simple symptomatic relief-the expectation is treatment that impacts and mitigates fundamental mechanisms that drive these disorders.'], ['Others experience declines in cognitive and functional capacity that range from mild decrements in certain cognitive functions over time to severe dementia among those with neurodegenerative diseases.', 'Learning and memory functions are also usually reduced, although in the absence of neurodegenerative disease learning and retrieval efficiency rather than memory storage are affected.'], ['Neurodegenerative disorders in the elderly are characterized by gradual loss of memory and cognitive function.', "Oxidative stress caused by reactive oxygen species is associated with progressive neuronal cell damage and death in Alzheimer's disease, one of the most common neurodegenerative disorders."], ['Defective clearance mechanisms result in toxic levels of soluble Abeta40 and Abeta42 oligomers, leading to impaired synaptic function, neurodegeneration and cognitive decline.', 'Understanding the normal versus impaired processing and clearance mechanisms affecting Abeta peptides will assist the development of more effective therapeutic agents to combat this progressive neurodegenerative condition that continues to devastate millions of patients globally.'], ['A pivotal feature that underlies the development of neurodegeneration is the accumulation of protein aggregates.'], ['Our data suggest that IDO inhibition may represent a novel therapeutic approach for the prevention of sarcopenia and possibly other age-associated conditions associated with KYN accumulation such as bone loss and neurodegeneration.'], ['We then consider how variability in cingulate-centered networks could contribute to a range of aging outcomes, including typical aging and unusually successful aging (dubbed "superaging"), as well as early neurodegenerative dementias, including frontotemporal dementia and Alzheimer\'s disease.'], ['On the basis of PET and MRI measures, participants were classified as having normal (A-) or abnormal (A+) amyloid, normal (T-) or abnormal (T+) tau, and normal (N-) or abnormal (N+) neurodegeneration.', 'With the amyloid-tau-neurodegeneration framework, HCTS was overrepresented in the T-(N)+ group, regardless of amyloid status.'], ["Huntington's disease (HD) is an autosomal dominant progressive neurodegenerative disorder mainly affecting the structure and functions of the striatum, cerebral cortex and hippocampus leading to movement disorders, cognitive dysfunctions and emotional disturbances.", 'While the normal Htt protein is vital for the neuronal differentiation and neuroprotection, experimental HD models and postmortem human HD brains have been characterized by neurodegeneration and defects in neuroregenerative plasticity in the basal ganglia and limbic system including the hippocampus.'], ['It has been specially found useful in neurodegenerative diseases and recent evidence points to the positive effects of meditation in preserving gray and white matter in the adult brain.'], ['However, recent evidence suggests post-TBI dementia exists as a distinct neurodegenerative syndrome, confounding AD diagnostic accuracy in clinical settings.'], ['We analysed associations between usual sleep habits and magnetic resonance imaging (MRI) markers of neurodegeneration (brain atrophy), vascular damage (white matter hyperintensities, WMH) and waste clearance (perivascular spaces, PVS) in older community-dwelling adults.'], ['The mechanisms underlying this age-dependent and region-selective neurodegeneration remain unclear.', 'Conversely, NCS-1 knockout exacerbated nigral neurodegeneration and downregulated Cav2.3.', "Thus, Cav2.3 and NCS-1 may constitute potential therapeutic targets for combatting Ca2+-dependent neurodegeneration in Parkinson's disease."], ["Parkinson's disease (PD) and frontotemporal dementia/amyotrophic lateral sclerosis (FTD/ALS) are insidious and incurable neurodegenerative diseases that represent a significant burden to affected individuals, caregivers, and an ageing population."], ["This article is part of the special issue entitled 'The Quest for Disease-Modifying Therapies for Neurodegenerative Disorders'."], ["Alzheimer's disease (AD) is the most prevalent neurodegenerative disorder, with approximately 29 million older people suffering from this disease worldwide.", 'AD is a complex and multifactorial neurodegenerative condition, characterized by complex pathology including oxidative stress, formation of aggregates of amyloid and tau, enhanced immune responses, metal deposition and disturbances in cholinesterase enzymes.'], ["Alzheimer's disease (AD) is the most common neurodegenerative disease, leading to dementia in the aging human brain."], ['Specifically, proteins at dopamine release sites that synthesize and package cytosolic dopamine, modulate its release and reuptake, and alter neuronal excitability show regional differences that provide linkages to the observed sensitivity to neurodegeneration.', 'The aim of this review is to outline the major components of dopamine homeostasis at neurotransmitter release sites and describe the regional differences most relevant to understanding why some, but not all, dopamine neurons exhibit heightened vulnerability to neurodegeneration.'], ["This is a growing area, with research to repurpose current medications affecting mitochondrial function being assessed in cancer, the immune system and neurodegenerative disorders including Parkinson's disease."], ["Chronic pain often occurs in the elderly, particularly in the patients with neurodegenerative disorders such as Alzheimer's disease (AD)."], ['In short, our study systematically explored combinatorial preventive treatment regimens for age-associated multi-morbidity, with an emphasis on neurodegeneration, and provided extensive evidence for their feasibility.'], ['In this study linear regression models were used to disentangle distinctive DMN activity patterns that are more profoundly associated with either normal ageing or a structural marker of neurodegeneration.'], ['Brain iron homeostasis governs both neurotransmission and neurodegeneration; hence, the role of iron in PD progression and neuronal health is apparent.'], ["Parkinson's Disease (PD) is the second most common neurodegenerative disease in the elderly population, with a higher prevalence in men, independent of race and social class; it affects approximately 1.5 to 2.0% of the elderly population over 60 years and 4% for those over 80 years of age."], ["BACKGROUND: The National Institute on Aging and Alzheimer's Association (NIA-AA) have proposed a new Research Framework: Towards a biological definition of Alzheimer's disease, which uses a three-biomarker construct: Ass-amyloid, tau and neurodegeneration AT(N), to generate a biomarker based definition of Alzheimer's disease."], ['Tau is a microtubule-associated protein that becomes dysregulated in a group of neurodegenerative diseases called tauopathies.'], ['Osteoarthritis (OA) is a degenerative chronic disease affecting the whole joint structures.'], ["Quatre themes sont ressortis des donnees: (1) la necessite d'une comprehension commune des cultures autochtones et occidentales dans le cadre des soins de sante; (2) l'amelioration de la communication interculturelle dans les discussions sur la sante; (3) l'ancrage du materiel de promotion de la sante dans la culture, et (4) les strategies autochtones de litteratie en matiere de sante et la sensibilisation aux maladies neurodegeneratives."], ['Additionally, one of the major epidemiologic trends of current times is the increase in chronic and degenerative diseases.'], ["Data included planned data collection acquired within the Consortium pour l'identification precoce de la maladie Alzheimer - Quebec (CIMA-Q) and Canadian Consortium on Neurodegeneration in Aging (CCNA) studies, as well as opportunistic data collection from various protocols."], ['Several studies indicate early brainstem alterations in a myriad of neurodegenerative diseases and dementias.'], ['It is characterized by epileptic seizures and neurodegeneration, and it develops rapidly until finally causing death.'], ["BACKGROUND AND AIM: Parkinson's disease (PD) is the second most prevalent neurodegenerative disorder in old age.", 'However, growing evidence indicates that peripheral processes, including metabolic changes, may precede and contribute to neurodegeneration.'], ['PubMed, PsycINFO, and Web of Science were searched from 2009 to 2019 using the keywords dual task, brain activity, gait, balance, aging, neurodegeneration, and other related search terms.'], ['In this review, we will analyze the applications of Ca2+ imaging in the fruit fly model, highlighting in particular their impact on the study of normal brain function and pathogenesis of neurodegenerative diseases.'], ['BACKGROUND: Life expectancy is increasing all over the world, although neurodegenerative disorders might drastically affect the individual activity of aged people.', 'Agerelated Macular Degeneration (AMD) is a late-onset, neurodegenerative retinal disease that shares several clinical and pathological features with AD, including stress stimuli such as oxidative stress, inflammation and amyloid formations.', 'Changes in the levels of systemic and ocular fluid essential metals might reflect the early stages of AMD, possibly disclosing neurodegeneration pathways shared with AD, which might open to potential early detection.'], ["Parkinson's disease (PD) is a well-known age-related neurodegenerative disorder associated with longer lifespans and rapidly aging populations.", 'Age-mediated degenerative neurological disorders can reduce the quality of life and also impose economic burdens.', 'Recently, natural compounds such as phytochemicals with fewer side effects have been reported as candidate treatments of age-related neurodegenerative diseases.'], ['CONCLUSION: The R4Alz battery is an easy to use psychometric battery with increasing difficulty levels and assumingly ecological validity, being entertaining for older adults, potentially free of demographic effects, and promising as a more accurate and early diagnosis tool of neurodegeneration.'], ['Neurodegenerative diseases (NDs) represent one of the most important public health problems and concerns, as they are a growing cause of mortality and morbidity worldwide, particularly in the elderly.', 'Despite remarkable breakthroughs in our understanding of NDs, there has been little success in developing effective therapies.', 'The use of natural products may offer great potential opportunities in the prevention and therapy of NDs; however, many clinical concerns have arisen regarding their use, mainly focusing on the lack of scientific support or evidence for their efficacy and patient safety.', 'In conclusion, the notable message that emerges is that natural products may represent a great promise for the treatment of many NDs, even if many unknown issues regarding the efficacy and safety of many natural products still remain.'], ["Based on the evidence from animal experiments, where incretin can protect against the pathophysiological processes of neurodegenerative diseases, clinical trials for the treatments of Alzheimer's disease (AD) and Parkinson's disease (PD) patients are currently ongoing."], ['Following recruitment of 65 human subjects in the age range of 70 to 82, we discerned healthy aging (HA) and non-healthy aging (NHA) cohorts discordant in the occurrence of one or more major diseases: (1) cancer, (2) acute or chronic cardiovascular diseases, (3) acute or chronic pulmonary diseases, (4) diabetes, and (5) stroke or neurodegenerative disorders.'], ['Ageing is an inevitable fundamental process for people and is their greatest risk factor for neurodegenerative disease.'], ['OBJECTIVE: Qualitative interpretation in bone scan is often complicated by the presence of degenerative joint disease (DJD), especially in the elderly patient.', 'The aim of this study is to compare objectively 99mTc-MDP tracer uptake between DJD and osseous metastases of the spine using semi-quantitative assessment with SPECT SUV.', 'Lesions were characterized into DJD or bone metastases based on its morphology on low-dose CT. Semi-quantitative evaluation using SUVmax was then performed on 89 DJD and 122 metastatic bone lesions.', 'RESULTS: The mean SUVmax for normal vertebrae was 7.08 +- 1.97, 12.59 +- 9.01 for DJD and 36.64 +- 24.84 for bone metastases.', 'The SUVmax of bone metastases was significantly greater than DJD (p value < 0.05).', 'The cutoff SUVmax value >= 20 gave a sensitivity of 73.8% and specificity of 85.4% in differentiating bone metastases from DJD.', 'The corrected SUVmax for both DJD and bone metastases was smaller with a mean of 6.82 +- 6.02 and 24.77 +- 20.61, respectively.', 'CONCLUSION: SPECT SUVmax was significantly higher in bone metastases than DJD.', 'A cutoff SUVmax of >= 20 can be used to differentiate bone metastases from DJD.'], ['Alexander disease (AxD) is an extremely rare neurodegenerative disorder caused by glial fibrillary acidic protein (GFAP) gene mutations.'], ["Alzheimer's disease (AD) is the most common neurodegenerative disease affecting the elderly worldwide."], ['Physical activity and exercise have become a central component of medical management of chronic illness, particular for the elderly who suffer from neurodegenerative disorders that impair their cognition and mobility.'], ['BACKGROUND: Neurodegeneration with brain iron accumulation (NBIA) is characterized by pathological iron accumulation in the subcortical nuclei and the cortex.', 'This is fundamental to understand the natural age-related iron deposition in the healthy brain prior to using this marker as a potential prognostic or diagnostic tool in neurodegenerative disorders.'], ["BACKGROUND: Blood markers indicative of neurodegeneration (neurofilament light chain; NFL), Alzheimer's disease amyloid pathology (amyloid-beta; Abeta), and neuroinflammation (kynurenine pathway; KP metabolites) have been investigated independently in neurodegenerative diseases.", 'However, the association of these markers of neurodegeneration and AD pathology with neuroinflammation has not been investigated previously.', 'Therefore, the current study examined whether NFL and Abeta correlate with KP metabolites in elderly individuals to provide insight on the association between blood indicators of neurodegeneration and neuroinflammation.', 'CONCLUSIONS: The current study shows that KP metabolite changes are associated with biomarker evidence of neurodegeneration.', 'Finally, the current study suggests that an association between neurodegeneration and neuroinflammation manifests in the periphery, suggesting that preventing cytoskeleton cytotoxicity by KP metabolites may have therapeutic potential.'], ['While imitation of meaningless gestures is a gold standard in the assessment of apraxia in patients with either stroke or neurodegenerative diseases, little is known about potential age-related effects on this measure.'], ['The aging of the world population is increasingly claimed as an alarming situation, since an ever-raising number of persons in advanced age but still physically active is expected to suffer from invalidating and degenerative diseases.'], ['For 30 patients diagnosed with aMCI in each group (n=60), biomarkers of neurodegeneration and amyloidopathy will be used to distinguish between aMCI with normal versus abnormal AD biomarkers.'], ['However, antioxidant defense mechanisms are often impacted negatively by the process of aging and/or degenerative disease leaving RPE susceptible to damage which contributes to retinal dysfunction.'], ["BACKGROUND: Preclinical studies suggest that exposure to general anaesthesia (GA) could cause neurodegeneration consistent with Alzheimer's disease (AD) pathology."], ['RESULTS: Four distinct patterns of multimorbidity were identified (Minimal chronic disease; Degenerative, lifestyle, and mental disorders; Neurological, functional and sensory disorders; and Metabolic, pulmonary and cardiovascular disorders).'], ['An external force causes primary injury, which is followed by secondary injury that triggers chronic neurodegenerative diseases.', 'Therefore, understanding the mechanisms underlying post-TBI secondary injury might provide insights into neurodegenerative diseases.', 'The secondary injury is known to share some physiological features with neurodegenerative diseases.'], ['On this basis, the use of H2S-donors could represent an exciting and intriguing strategy to be pursued for the treatment of neurodegenerative diseases (NDDs).'], ["Neuroinflammation and cholinergic dysfunction, leading to cognitive impairment, are hallmarks of aging and neurodegenerative disorders, including Alzheimer's disease (AD)."], ["Alzheimer's disease (AD) is the most frequent neurodegenerative disorder in the elderly, occurring in approximately 20% of people older than 80."], ["Evidence from the literature suggests that in addition to demonstrated increases in somatic SNVs during aging in normal brains, somatic mutation may also play a role in late-onset, sporadic neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease."], ['Further assessment of healthy aged cohorts that retain intact neurological function will be critical to understand the etiology of neurodegenerative disease and the role of age at risk.'], ['Importantly, mice expressing a hypomorphic STI1 allele presented spontaneous age-dependent hippocampal neurodegeneration and reduced hippocampal volume, with consequent spatial memory deficit.', 'We suggest that impaired STI1 function compromises Hsp70/Hsp90 chaperone activity in mammals and can by itself cause age-dependent hippocampal neurodegeneration in mice.'], ['Altogether, this study demonstrates the major and independent contribution of TDP-43 pathology on neurodegeneration and provides further insight into the regional distribution of TDP-43 in non-FTLD subjects.'], ['Among the many tissues that could have been chosen to explore our hypothesis, to keep the paper manageable, we chose to focus on a selected number of tissues, namely bone, cartilage, muscle, and the brain, which are important for mobility and cognition and affected in several common age-related diseases, including osteoporosis, osteoarthritis, sarcopenia, and neurodegenerative diseases.'], ['For example, the epsilon 2 and epsilon 4 alleles of apolipoprotein E are associated with extreme longevity and late-onset neurodegenerative disease, respectively.'], ["Alzheimer's disease (AD), a neurodegenerative disorder, is the leading cause of dementia in the world whose aetiology is still unclear."], ['She leads the Primary Care Group of the Dementia and Neurodegenerative Diseases Research Network (DeNDRoN), a national network of researchers which aims to explore the whole spectrum of dementia care from diagnosis and early detection, through to advanced dementia and end of life care.'], ['Further studies are needed to determine potential long-term implications of such change in relation to cellular aging and the development of neurodegenerative disorders.'], ["MicroRNAs (miRNAs) have been reported to contribute to the pathophysiology of the Parkinson's disease (PD), an age related-neurodegenerative disorder.", 'Our in-silico analysis identified candidate target genes and TFs, including those related to neurodegeneration and PD.'], ['The finding of an effective cure or treatment for neurodegenerative diseases is one of the biggest challenges for this century.', 'Aging, the primary risk factor for the majority of neurodegenerative disorders, is linked to the impairment of degradative compartments such as lysosomes and autophagosomes.', "Besides, many genetic factors for Alzheimer's disease, Parkinson's disease, or frontotemporal dementia, as examples of frequent neurodegenerative diseases, are causative of endo-lysosomal and autophagosomal dysfunctions.", 'In this review, the interplay between the impairment of degradative compartments, the secretion of EVs, and their pathological/beneficial role in neurodegeneration is described.'], ['The dysregulation of mTOR is involved in human diseases including cancer, cardiovascular diseases, neurodegenerative diseases, and epilepsy.'], ['Osteoarthritis is a degenerative disease that strongly correlates with age and promotes the breakdown of joint cartilage and subchondral bone.'], ["Generally, neurodegenerative diseases, such as Parkinson's, are disorders of aging.", 'The contribution of cellular senescence to neurodegeneration is still unclear.'], ['Aberrant insulin and adipokine signaling has been implicated in cognitive decline associated with both type 2 diabetes mellitus and neurodegenerative diseases.'], ['The acquisition of brain tissue for research purposes is an important endeavour in research on ageing, pathological diagnosis, and the advancement of treatment of neurological or neurodegenerative diseases.'], ['This review revealed that no studies have examined the effects of cardiorespiratory fitness on neurodegenerative disease in Africa.', 'African nations, like many other developing countries, have an aging population that is growing and will face an increased risk of neurodegenerative declines.', 'It is therefore imperative that new research projects be developed to explore the role of the cardiorespiratory fitness in neurodegenerative disease prevention in African nations.'], ["Finally, we constructed a model combining markers for amyloid deposition, tauopathy, and neurodegeneration (ATN), in accordance with the National Institute on Aging and Alzheimer's Association research framework."], ['Aging-related neurodegenerative disorders are frequently associated with the aggregation of multiple amyloidogenic proteins (APs), although the reason why such detrimental phenomena have emerged in the post-reproductive human brain across evolution is unclear.', 'Of relevance, it is noteworthy that cross-seeding (CS) of APs has recently been characterized in cellular and animal models of neurodegenerative disease, and that normal physiological CS of multiple APs has also been observed in lower organisms, including yeast and bacteria.', 'On the other hand, subsequent neurodegeneration caused by APs in parental brain through the antagonistic pleiotropy mechanism in aging, may suggest that synergistically, multiple APs might be more detrimental compared to singular AP in neurodegeneration.', 'Taken together, we suggest that the CS of multiple APs might be involved in both evolvability and neurodegenerative disease in human brain, which may be mechanistically and therapeutically important.'], ['Because AGEs can be a factor in aging and in the development or worsening of many degenerative diseases, it is important to find a way to reduce the PEN levels in our body.'], ['A subanalysis of isolated, non-reoperative MVS for degenerative disease was also performed.'], ["These results illustrate that nanoindentation and topographic analysis of live senescent brain endothelial cells can provide insights into cerebrovascular dysfunction in neurodegenerative diseases such as Alzheimer's disease."], ['This study aimed to examine the relationship between sleep experiences during the young adulthood, midlife, and late-life periods and in vivo cerebral beta-amyloid (Abeta) deposition and AD signature regional neurodegeneration in cognitively normal (CN) old adults.', 'Neither the quality nor duration of sleep during young adulthood was related to Abeta burden or neurodegeneration.'], ['SIRT2 inhibition rescues neurodegenerative disease symptoms and hence SIRT2 is a potential therapeutic target for neurodegenerative disease.'], ['The INECO Frontal Screening (IFS) is a brief neuropsychological screening tool, developed to assess executive dysfunction in neurodegenerative disorders.'], ['CONCLUSION: Subjective hearing loss was not found to be associated with significantly different dementia neuropathology, which counters hypotheses on hearing loss causing permanent neurodegeneration and cognitive decline.', 'Hearing aid users were found to have a lower prevalence of dementia for similar levels of neurodegeneration, suggesting a potential neuroprotective effect of hearing aids.'], ['PURPOSE: In our aging society, the prevalence of degenerative spinal diseases rose drastically within the last years.'], ['However, no increased manifestation of neurodegenerative disorders was reported.', 'CONCLUSIONS: With this case report, we illustrate the necessity of a systematic work-up for neurodegenerative disorders in patients with arachnoid cysts and emerging cognitive decline.'], ["Parkinson's disease is a complex slowly progressive neurodegenerative disorder with motor and non-motor symptoms affecting daily living."], ['There is a gap of knowledge on the beneficial effects of HMB combined with exercise to preserve cognitive functions in aging and age-related neurodegenerative diseases.'], ['With increased life expectancy worldwide, there is an urgent need for improving preventive measures that delay the development of age-related degenerative diseases.', 'In humans, analysis of data from the Atherosclerosis Risk in Communities (ARIC) study revealed that hydration level, assessed at middle age by serum sodium concentration, is associated with markers of coagulation and inflammation and predicts the development of many age-related degenerative diseases 24 years later.', 'The analysis estimates that improving hydration throughout life may greatly decrease the prevalence of degenerative diseases, with the most profound effect on dementia, heart failure (HF), and chronic lung disease (CLD), translating to the development of these diseases in 3 million fewer people in the United States alone.'], ['Aberrant changes in mitochondrial dynamics and cristae structure are associated with ageing and numerous human diseases (e.g., cancer, diabetes, various neurodegenerative diseases, types of neuro- and myopathies).'], ['Pathologic aggregates of tau protein are observed in several neurodegenerative diseases and are used to diagnose and stage disease postmortem.', "This chapter describes the development and characterization of several positron emission tomography radioligands used to detect tau pathophysiology in vivo, and how these ligands are being used in clinical aging and neurodegenerative disease research with a focus on imaging tau aggregates in Alzheimer's disease."], ['The Mediterranean diet is considered as the foremost dietary regimen and its adoption is associated with the prevention of degenerative diseases and an extended longevity.'], ['Dementia, a common age-related disease, is a clinical disorder triggered by neurodegeneration.'], ['Cross-sectional and longitudinal comparisons between these 2 groups were performed for each amyloid, tau, and neurodegeneration (AT(N)) profile.'], ['Furthermore, the exposure of the olfactory system to the external environment make it more susceptible to mechanical injury and trauma, which can cause degenerative neuroinflammation.'], ["The single largest risk factor for etiology of neurodegenerative diseases like Alzheimer's disease is increased age.", "While aged microglia have been frequently identified in neurodegenerative diseases such as Alzheimer's disease, there is no conclusive evidence that proves a causal role.", 'Iron-overloading cultured microglia causes them to take on a senescent phenotype and can cause changes in models of neurodegeneration similar to those observed in patients.', 'This review considers how this model could be used to determine the role of senescent microglia in neurodegenerative diseases.'], ['Patients with CSM had increased risks of neurological deterioration or spinal cord injury with nonoperative management.'], ['These results suggest that MPs may be involved in the pathophysiology of neurodegenerative disorders.'], ['Stress granules regulate RNA translation during cellular stress, a mechanism that is generally presumed to be protective, since stress granule dysregulation caused by mutation or ageing is associated with neurodegenerative disease.', 'This establishes stress granules as a viable therapeutic target not only for hearing loss but also other neurodegenerative diseases.'], ['Over the last several years, an increasing number of reports on brain DNA methylome reported the association between aberrant methylation and the abnormalities in the expression of critical genes known to have critical roles during aging and neurodegenerative diseases.', 'Consequently, the role of methylation in understanding neurodegenerative diseases has been under focus.', 'This review outlines the current knowledge of the human brain DNA methylomes during aging and neurodegenerative diseases.', 'Additionally, we summarize the key aspects and methylated genes identified from brain methylome studies on neurodegenerative diseases.', 'The brain methylome studies could provide a basis for studying the functional aspects of neurodegenerative diseases.'], ["Neurodegenerative disorders, including Alzheimer's disease (AD), are prevalent among the elderly."], ['This axis is gaining ever more traction in fields investigating the biological and physiological basis of psychiatric, neurodevelopmental, age-related, and neurodegenerative disorders.'], ["However, if the iron is excessively deposited in the aged brain, it is closely related to the occurrence of various neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and Friedreich's ataxia."], ["Apart from amyloid beta deposition and tau neurofibrillary tangles, Alzheimer's disease (AD) is a neurodegenerative disorder characterized by neuronal loss and astrocytosis in the cerebral cortex.", 'We stratified the samples by disease status, and discovered that this variant modulates neuronal proportion not only in AD cases, but also several neurodegenerative diseases and in elderly cognitively healthy controls.', 'These results suggest that common pathways are implicated in these neurodegenerative diseases, that implicate neuronal survival.', 'In summary, we identified a protective variant in the TMEM106B gene that may have a neuronal protection effect against general aging, independent of disease status, which could help elucidate the relationship between aging and neuronal survival in the presence or absence of neurodegenerative disorders.'], ['Accordingly, changes in gene expression following the pluripotency transition, and subsequent transitions such as the embryonic-fetal transition, while providing tumor suppressive and antiviral survival benefits also result in a loss of regenerative potential leading to age-related fibrosis and degenerative diseases.'], ['The prevalence of dementia and other neurodegenerative diseases is rapidly increasing in aging nations.', 'Here, we review current brain organoid protocols, the pathophysiology of neurodegenerative disorders, and early studies with brain organoid neurodegeneration models.', 'Altogether, we believe that brain organoids models, improved with classical and emerging molecular and analytic tools, have the potential to unravel the opaque pathophysiological mechanisms of neurodegeneration and devise novel treatments for an array of neurodegenerative disorders.'], ['BACKGROUND: Leukocyte telomere length (LTL) is associated with the aging process and age-related degenerative diseases.'], ['As such, they evolved to play key roles in organismal homeostasis, and defects in these proteins have been linked to a plethora of diseases, including cancer, neurodegeneration, and aging.'], ['Alpha-synuclein (AS), a 14 kDa synaptic protein associated with several neurodegenerative diseases, exists natively within erythrocytes (ERC).'], ['Metformin also retards aging in model organisms and reduces the incidence of aging-related diseases such as neurodegenerative disease and cancer in humans.'], ['Targeting redox-active biometals copper and iron is relevant in the context of protection against the oxidation of biomolecules and the generation of oxidative stress, observed in several conditions and considered an event that might promote sporadic prion diseases as well as other neurodegenerative disorders.'], ['The same elevation caused upregulation of proteins associated with glaucomatous neurodegeneration in the retina and optic nerve, including complement 1q, interleukin 6, and brain-derived neurotrophic factor.'], ['Neuroinflammation, as defined by the activation of microglia and astrocytes, has emerged in the last years as a key element of the pathogenesis of neurodegenerative diseases based on genetic findings and preclinical and human studies.', 'With glial cell activation as a potential therapeutic target in neurodegenerative diseases, the translational research between cell biologists, chemists, physicists, radiologists, and neurologists should be strengthened.'], ['BACKGROUND: Several recent studies have examined the positive effects of physical exercise and equilibrium on individuals with neurodegenerative diseases.'], ['Healthy aging is associated with structural and functional changes in the brain even in individuals who are free of neurodegenerative diseases.'], ["Alzheimer's disease (AD) is the most common progressive human neurodegenerative disorder affecting elderly population worldwide."], ["Epidemiologically, the development of age-related neurodegenerative diseases such as Alzheimer's and Parkinson's disease is associated with pronounced sleep disruption, whereas emerging mechanistic studies suggest that sleep disruption may be causally linked to neurodegenerative pathology, suggesting that sleep may represent a key therapeutic target in the prevention of these conditions.", 'In this review, we discuss the physiology of sleep, the pathophysiology of neurodegenerative disease, and the current literature supporting the relationship between sleep, aging, and neurodegenerative disease.'], ['We hypothesize that the combination of age- and disease-specific changes in cerebral Kyn pathway activity could contribute to reduced neurogenesis and increased excitotoxicity in neurodegenerative disease.'], ['Although amyloidosis is rare, amyloid deposits play a role in several conditions as degenerative diseases.', "Thus, the development of antiamyloid curative treatments may be a rational approach to treat neurodegenerative conditions like Alzheimer's disease in the future."], ['Neurodegenerative diseases are strongly age-related and currently cannot be cured, with a surge of patient numbers in the coming decades in view of the emerging worldwide ageing population, bringing healthcare and socioeconomic challenges.', 'Conversely, defective mitophagy leads to accumulation of damaged mitochondria and cellular dysfunction, contributing to ageing and age-predisposed neurodegeneration.'], ['The microtubule-associated protein tau undergoes aberrant modification resulting in insoluble brain deposits in various neurodegenerative diseases, including frontotemporal dementia (FTD), progressive supranuclear palsy, and corticobasal degeneration.'], ['The current study explores current decision-making practices used by speech language therapists (SLTs) surrounding contexts related to palliative care, dementia, neuro-degenerative diseases, guardianship/family decisions, and other issues relevant to ongoing care of individuals with dysphagia.'], ["For example, progression of age-related neurodegenerative diseases such as Alzheimer's and Parkinson's has been linked to increased inflammation from gut microbiota in old mammals, which, in turn, may be linked bidirectionally with reduced ISC function."], ["Recent genome-wide association studies of Huntington's disease (HD) primarily highlighted genes involved in DNA damage repair mechanisms as modifiers of age at onset and disease severity, consistent with evidence that more DNA repair genes are being implicated in late age-onset neurodegenerative diseases.", 'A potential universal trigger of oxidative DNA damage shared in these late age-onset diseases is the increase of reactive oxygen species (ROS) in human aging, defining an age-related mechanism that has defied other hypotheses of neurodegeneration.', 'We discuss the potential commonality of DNA damage repair pathways in HD and other neurodegenerative diseases.'], ['INTRODUCTION: An ageing population and steady increase in the rates of neoplasms and chronic degenerative diseases poses a challenge for societies and their healthcare systems.'], ['Frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS) are progressive and fatal neurodegenerative disorders showing mislocalization and cytosolic accumulation of TDP-43 inclusions in the central nervous system.', 'The inhibition of TDP-43 proteostasis in the presence of selective inhibitors against the proteasome and macroautophagy systems revealed that these two systems are both severely involved in TDP-43 accumulation and have a strong influence on each other in neurodegenerative disorders associated with TDP-43.'], ['Its etiology and pathogenesis remains unclear, although some theories indicate that myxoid cysts could appear as a result of a mucoid degeneration of the connective tissue, the exit of synovial fluid from the DIJ capsule, repetitive trauma, the herniation of tendon sheaths or synovial linings associated with degenerative joint diseases and osteophytes in the elderly, or due to an overproduction of mucin by fibroblasts (1,3,4).'], ['PURPOSE: To study brain metabolic changes under normal aging and to collect reference data for the study of neurodegenerative diseases.'], ['Long-term survival in this cohort has increased to the point where patients are presenting for noncardiac surgery related to degenerative diseases of aging.'], ['However, regarding all secondary endpoints including neurological death, neurological deterioration, SRS-related complications, leukoencephalopathy, local recurrence, newly-developed tumors, meningeal dissemination, salvage SRS, whole brain radiotherapy and surgery and decreased mini-mental state examination scores, the elderly patient group was not inferior to the non-elderly patient group.'], ['BACKGROUND: Lewy body diseases, a family of aging-related neurodegenerative disorders, entail loss of the catecholamine dopamine in the nigrostriatal system and equally severe deficiency of the closely related catecholamine norepinephrine in the heart.'], ['Future work should confirm these observations at the protein level to better understand how changes in VEGF transcription and translation relate to neurodegenerative disease.'], ["Alzheimer's Disease (AD) is the most common neurodegenerative disorder in the elderly."], ['Although the general roles of several signaling pathways in the pathogenesis of neurodegenerative disorders have so far been identified, the exact pathophysiology of neuronal disorders and their effective treatments have not yet been precisely elucidated.', 'The present review highlights the neuroprotective effects of AST mainly based on its anti-inflammatory, antioxidative, and anti-apoptotic properties that underlies its pharmacological mechanisms of action to tackle neurodegeneration.'], ['These aspects have implications in degenerative diseases and conditions as well as the aging process.'], ['Oxidative stress plays an important role in aging-related neurodegeneration.'], ['Accumulating evidence indicates that exercise can enhance brain function and attenuate neurodegeneration.', "Activated microglia and several pro-inflammatory cytokines play active roles in the pathogenesis of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease."], ["AGEs also play an important role in neurodegenerative diseases including Alzheimer's (AD) and Parkinson's disease (PD)."], ['This makes it so far a unique brain area to study compensatory mechanisms that may prevent neurodegeneration.'], ['BACKGROUND: The Comprehensive Assessment of Neurodegeneration and Dementia (COMPASS-ND) cohort study of the Canadian Consortium on Neurodegeneration in Aging (CCNA) is a national initiative to catalyze research on dementia, set up to support the research agendas of CCNA teams.', 'RESULTS: The CCNA COMPASS-ND cohort includes participants from across Canada with various cognitive conditions associated with or at risk of neurodegenerative diseases.'], ['Cervical degenerative disease is the most common cause of acquired disability in patients over the age of 50.'], ['Human tauopathies are neurodegenerative diseases with accumulation of abnormally phosphorylated and aggregated tau proteins forming neurofibrillary tangles.'], ["BACKGROUND: Asymmetrical patterns of cerebral damage have been widely observed in a range of neurodegenerative diseases, including Alzheimer's disease (AD)."], ['BACKGROUND: Knee osteoarthritis (KOA), the most common type of osteoarthritis, is a chronic degenerative joint disease accompanied by pain and functional limitation for the elderly.'], ['Brain Age Estimation (BAE) has attracted more attention in recent years and it would be so helpful in early diagnosis of some neurodegenerative diseases such as Alzheimer, Parkinson, Huntington, etc.', 'This refers to the effects of neurodegenerative diseases on brain structure while making the whole of it older.'], ['Current insight points towards a multifactorial cause of cognitive decline at old age, in which vascular components like atherosclerosis, arterio(lo)sclerosis, (micro)infarcts, and amyloid angiopathy play an important role alongside other markers of neurodegeneration.', 'The consequent limitations of nosology may be alleviated by addition of a vascular component to the recently introduced amyloid/tau/neurodegeneration etiological classification system for dementia.'], ['The dysregulation of ethanolamine plasmalogens in the circulatory system, especially those containing polyunsaturated fatty acids (PUFA), might be likely associated with neurodegeneration.'], ['CONCLUSION: We provide evidence that the STMS performs similarly to the MoCA in a variety of settings and neurodegenerative syndromes.'], ['With over 400 mutations identified in the LMNA gene (encoding for A-type lamins) associated with more than ten distinct degenerative disorders, the role of lamins as genome caretakers and the contribution of lamins dysfunction to disease are unarguable.'], ['We evaluated sex differences in MRI-based volume loss and differences in predictors of this neurodegeneration in cognitively healthy older adults.'], ['Functional analysis suggests that the pathways involved in neurodegenerative diseases, synaptic vesicle cycle, and endocytosis were overly represented within age- and gender-associated lncRNA-correlating genes.'], ['This atlas can be used as a basis to understand changes in the vasculature during aging and neurodegeneration, as well as vascular and physiological effects in neuroimaging.'], ["Neurodegenerative diseases such as multiple sclerosis, Parkinson's disease, and certain dementias are independent risk factors for BP."], ['The biochemical mechanisms of this devastating neurodegenerative disease have not yet been clearly understood.'], ['The information presented in this article will hopefully fuel further research into the role of GPR39 in neurodegeneration and help in identifying novel therapeutic targets for dementia.'], ['Here we review evidence of melanopsin-expressing cell alterations in aging and neurodegenerative diseases and their correlation with the development of circadian rhythm disorders.'], ['This article reviews the available data looking at the association between circadian dysregulation and cardiometabolic, neurologic, and neurodegenerative disease risk.'], ['Patients under 18 years old, older than 90 years old, known to be affected by neurodegenerative diseases, demyelinating disorders or stroke and/or a brain tumor, were excluded from the study.'], ['The association between Li treatment and BrainAGE was independent of long-term thymoprophylactic response and thus may generalize beyond bipolar disorders, to neurodegenerative disorders.'], ['INTRODUCTION: Hip and knee arthroplasties have revolutionised the management of degenerative joint diseases and, due to an ageing population, are becoming increasingly common.'], ["Neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), and amyotrophic lateral sclerosis (ALS), currently affect more than 6 million people in the United States.", 'Regardless of the underlying cause of the disorder, age is the strongest risk factor for developing these maladies, suggesting that changes that occur in the aging brain put it at increased risk for neurodegenerative disease development.', 'Thus, compounds that have multiple biological activities that can impact the various age-associated changes in the brain that contribute to neurodegenerative disease development and progression are needed.', 'The plant-derived flavonoids have a wide range of activities that could make them particularly effective for blocking the age-associated toxicity pathways associated with neurodegenerative diseases.', 'Overall, the preclinical data strongly support further investigation of specific flavonoids for the treatment of neurodegenerative diseases.'], ['BACKGROUND: Quantifying hippocampal atrophy caused by neurodegenerative diseases is important to follow the course of the disease.'], ['These findings suggest that mTBI initiates a lifelong neurodegeneration process that outweighs the risks associated with sustaining a mTBI at an older age.'], ['Among participants with EAT-10>15 points, women gender and neurodegenerative diseases were more prevalent (p=0.04, p=0.002; respectively); number of chronic diseases, number of drugs and FRAIL score were higher (p=0.001 for each), and HGS, UGS, MNA-SF scores were lower (p=0.002, p=0.01, p<0.001; respectively).', 'CONCLUSION: Dysphagia is associated with frailty irrespective to age, presence of neurodegenerative diseases, number of chronic diseases and drugs.'], ['A correlation between carbonylation of proteins and human disease progression has been shown in ageing, diabetes, obesity, chronic renal failure, neurodegeneration and cardiovascular disease.'], ['Recent years of research on mRGCs have identified a broad number of neurodegenerative diseases in the eye and the brain with altered physiologic light responses, leading to disturbances of non-image forming light response(s).'], ['However, the mechanisms by which microglial gene expression is regulated in a region-specific manner over the course of normal aging and in neurodegenerative disease are only beginning to be deciphered.', 'Our findings suggest that microglial genes show enriched expression in AD-vulnerable brain regions, are upregulated during aging and neurodegeneration in mice, and are upregulated in pathologically affected brain regions in AD.', 'Taken together, our data-driven findings from multiple publicly accessible datasets reemphasize the importance of microglial gene expression alterations in AD and, more importantly, suggest that regional and sex-specific variation in microglial gene expression may be implicated in risk for and progression of neurodegenerative disease.'], ["Age is the main risk factor for a number of human diseases, including neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis, which increasing numbers of elderly individuals suffer.", 'Here, we review the role of mitochondrial oxidative stress in the aging process, with a specific focus on neurodegenerative diseases.', 'Understanding the molecular mechanisms involving mitochondria and oxidative stress in the aging and neurodegeneration may help to identify new strategies for improving the health and extending lifespan.'], ["Importance: A National Institute on Aging and Alzheimer's Association workgroup proposed a research framework for Alzheimer disease in which biomarker classification of research participants is labeled AT(N) for amyloid, tau, and neurodegeneration biomarkers."], ['Introduction: Neuroinflammation is a common pathophysiological mechanism in neurodegenerative diseases (ND).'], ['Even in the absence of neurodegenerative disorders, healthy aging affects perception and cognition.'], ['The purpose of this review is to examine the contribution of inflammation and hypercortisolaemia, which are frequently associated with major depression, to neurodegeneration and how they detrimentally impact on brain energy metabolism.'], ["Purpose/Aim: Alzheimer's disease (AD), the primary cause of dementia in the elderly, is one of the leading age-related neurodegenerative diseases worldwide.", 'Data from an increasing number of studies substantiate a role for the newly discovered "exercise hormone" irisin and its protein precursor FNDC5 in bone loss and AD-associated neurodegeneration.'], ["Translational studies investigating alternative uses of cord blood have also shown that these cells not only stimulate neurogenesis in the aged brain but are also potentially therapeutic in the treatment of adult neurodegenerative disorders including amyotrophic lateral sclerosis, Alzheimer's disease, ischemic stroke, traumatic brain injury, and Parkinson's disease.", 'Although the exact mechanism(s) of action that provide the beneficial effects observed from a cord blood cell-based therapy are currently unknown, several studies using models of neurodegenerative disease have shown these cells are immune-modulatory and anti-inflammatory.'], ['Findings have important implications on interventions, suggesting the potential utility of treatments targeting the brain endothelium and blood brain barrier to combat SVD and associated neurodegenerative diseases.'], ['Recent concern has been raised that the neurocognitive phenotype in the post-ART era has changed to reflect the addition of cortical features, suggestive of synergistic age-related neurodegeneration.'], ['Both a decrease in the level of stem cells and increase in ROS production can lead to the development of different neurodegenerative diseases.'], ['Aging is associated with cognitive decline and increased vulnerability to neurodegenerative diseases.'], ['RESULTS AND DISCUSSION: Common neurological causes of impaired balance and mobility are sensory deficits (reduced vision, peripheral neuropathy, vestibulopathy), neurodegeneration in disorders with an impact on movement control and motoric functions (Parkinsonian syndromes, cerebellar ataxia, vascular encephalopathy) and functional (psychogenic) disorders, particularly a fear of falling.'], ['Aging drives a progressive decline in cognition and decreases synapse numbers and synaptic function in the brain, thereby increasing the risk for neurodegenerative disease.'], ['BACKGROUND: The treatment strategy for evolutive septic arthritis (SA) with coexistent degenerative joint disease is not well established.'], ['BACKGROUND: The incidence of surgery for degenerative cervical spine disease (DCSD) has risen by almost 150% in the USA in the last three decades and stabilized at slightly over 70 operations/100,000 people.', 'METHODS: Data from the Finnish Hospital Discharge Register (FHDR), the Cause of Death Register, and the registers of the Social Insurance Institution were combined to analyze all the primary operations for DCSD or rheumatoid atlanto-axial subluxation (rAAS).', 'CONCLUSIONS: The age-adjusted incidence of surgery for DCSD has risen in Finland by 76%, but the rise has plateaued.', 'Surgery for radiculopathy, especially for foraminal stenosis, increased more steeply than surgery for degenerative medullopathy, with vast regional differences in the operation incidences.'], ['The risk for cardiovascular, stroke, cancer, and neurodegenerative diseases significantly increases with aging, especially in people aged 60 years and older in the USA.'], ['Both have important roles in human diseases such as aging, renal degeneration, neurodegenerative disorders, and cancer.'], ['Aging is the greatest risk factor for most diseases including cancer, cardiovascular disorders, and neurodegenerative disease.', 'In humans, dietary patterns including the Mediterranean, Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) and Okinawan diets are associated with improved age-related health and may reduce neurodegenerative disease including dementia.'], ['As the number of older people increases, so too does the prevalence of neurodegenerative disease.', 'Worldwide, health organisations have identified the need for practical, affordable interventions to slow or delay the onset of neurodegenerative diseases such as dementia, for which there are multiple modifiable risk factors.', 'This narrative review synthesises the evidence for the neurophysiological effects of physical activity, sleep and sedentary behaviour independently, with a particular focus on brain structure, function and neurodegenerative disease risk.'], ['The role of PLCG2 in immune system signaling suggests it may also protect against other neurodegenerative diseases and possibly associates with longevity.', 'We studied the effect of the rs72824905-G on seven neurodegenerative diseases and longevity, using 53,627 patients, 3,516 long-lived individuals and 149,290 study-matched controls.', 'Concluding, rs72824905-G has a protective effect against multiple neurodegenerative diseases indicating shared aspects of disease etiology.'], ["Longstanding psychological stress has been associated with increased risk of neurodegenerative disorders, such as dementia and Alzheimer's disease.", 'In a prospective population study of women (n = 81), we tested if midlife stress (mean age 49 years) was associated with late-life biomarkers of neurodegeneration in cerebrospinal fluid (CSF) (mean age 74 years) in linear regression models.'], ['SNCB is thought to function as an antagonist of alpha-synuclein in neurodegenerative diseases, but the exact role of SNCB remains unclear.'], ['Based on theories of neuronal integrity changes that accompany aging, we assessed the relative contribution of: 1) premorbid cognitive reserve, 2) current brain integrity (gray and white matter markers of neurodegenerative disease), and 3) current cognition (specifically domains of processing speed/working memory, episodic memory, and motor function) on intraoperative neurophysiological variability as measured from a common intraoperative tool, the Bispectral Index Monitor (BIS).'], ['The ready accessibility of HUCPVC constitutes a significant incentive to continue the exploration of their therapeutic potential on neurodegenerative diseases.'], ['Rapamycin (Rap) and its derivatives, called rapalogs, are being explored in clinical trials targeting cancer and neurodegeneration.'], ['METHODS: Data was derived from the Arizona Study of Aging and Neurodegenerative Disorders.'], ['Defects in glucose utilization and mitochondrial dysfunction are hallmarks of nearly all neurodegenerative diseases and are also associated with the cognitive decline that occurs as the brain ages.', 'Chronic neuroinflammation driven by glial activation is commonly implicated as a contributing factor to neurodegeneration and cognitive impairment.'], ["The purpose of the 'First Regional Healthy Aging and Dementia Research Symposium' was to discuss the latest research in healthy aging and dementia research, public health trends related to neurodegenerative diseases of aging, and community-based programs and research studying health, nutrition, and cognition.", 'Healthcare professionals, from geriatricians to social workers working with patients with neurodegenerative diseases, also presented.'], ['One explanation for this lack of treatment effect may be that depressive symptoms can reflect the progression of AD, rather than clinical depression and are a consequence of more severe neurodegeneration.'], ['New biomarkers are currently being developed to allow determinations of multiple pathological processes including neuroinflammation, synaptic dysfunction, metabolic impairment, protein aggregation and neurodegeneration.'], ["Alzheimer's disease (AD) is a neurodegenerative disease considered the major cause of dementia in the elderly."], ['Age-dependent decrease of expression from those two septins involved in synapses reinforces their possible link with cognitive decay and neurodegenerative diseases associated with aging.'], ['Together, these findings establish brain endothelial VCAM1 at the blood-brain barrier as a possible target to treat age-related neurodegeneration.'], ['Neurodegenerative diseases are more common in older individuals and are progressively debilitating.', 'Due to the aging of the American population, the burden of neurodegenerative diseases on the health care infrastructure will likely significantly increase in the near future.', 'Although translation into clinical practice is slow, there are a few examples of instances where precision medicine is making a difference in the care of patients with neurodegenerative diseases that may be driven by genetic background.', 'This article provides a brief overview of the current knowledge of genetic influences on two common neurodegenerative diseases, Alzheimer Disease and Parkinson Disease, as well as ways this knowledge is being tested for a precision medicine approach to care.'], ['Evidence suggests that neurones activate a senescence-like mechanism that could contribute to neurodegeneration.'], ['Recent research has brought attention to the brain pigment due to its possible role in neurodegeneration.'], ['Further, these intrusion error were related to brain amyloid load, indicating their importance as potential primary markers of AD-related neurodegeneration.'], ['OBJECTIVE: As a result of continuously increasing life expectancy, the number of requests for surgery to treat degenerative diseases of the spine in the elderly population will increase.'], ['We developed sensitive cellular assays using human embryonic kidney-293T cells to quantify intracellular self-propagating conformers of Abeta in brain samples from patients with AD or other neurodegenerative diseases.'], ['Neurodegenerative disorders are often characterized by neuronal "slowing," which may be assessed in different ways.'], ['The identification of diagnostic-prognostic biomarkers of dementia has become a global priority due to the prevalence of neurodegenerative diseases in aging populations.'], ["This study investigated the associations of 8 plasma PC levels (PC aa [14:0_14:0], PC aa [16:0_16:0], PC aa [16:0_18:2], PC aa [16:0_22:6], PC aa [18:0_18:0], PC aa [18:0_18:1], PC aa [18:0_20:4], PC aa [18:1_18:1]) with cross-sectional and longitudinal measures of amyloid deposition, Alzheimer's disease-associated neurodegeneration (glucose metabolism and cortical thickness), and cognition (global- and domain-specific) of 1440 cognitively unimpaired participants (47% female, aged 50.7-95.3 years) in the Mayo Clinic Study of Aging."], ['The generation of these unique and important datasets will aid in delineating the molecular mechanisms underpinning primate brain aging, in addition to deciphering the regulatory biochemical cascades governing neurodegenerative disease pathogenesis.'], ["Alzheimer's disease is a neurodegenerative disorder and the most common and devastating form of dementia."], ['This study highlights the need for health care resource allocation to neurodegenerative disorders in an ageing African continent.'], ['If left untreated, hearing loss can perpetuate development of neurodegenerative diseases, including dementia.'], ["There is increasing evidence suggesting that amyloidogenic proteins might form deposits in non-neuronal tissues in neurodegenerative disorders such as Alzheimer's or Parkinson's diseases.", 'Using immunohistochemistry (IHC) and mass spectrometry tissue imaging (MALDI-MSI), fresh frozen human skin samples were analyzed for the expression and localization of neurodegenerative disease-related proteins.'], ['We aimed to estimate the burden of neurodegenerative disorders and its relationship with sociodemographic index in the EMR countries from 1990 to 2016.', 'Neurodegenerative disorders contributed to 5.4% of total DALY and 4.6% of total YLD among the older EMR population (70 years of age or older in 2016).', 'The YLD:DALY ratio of neurodegenerative diseases declined during this period in the low-income but not the high-income EMR countries.', 'With aging of the EMR populations, countries should target the modifiable risk factors of neurodegenerative diseases to control their increasing burden.'], ['However, ageing presents unique challenges in patients with MS largely as a result of their increased frequency of age-related and MS-related comorbidities as well as transition of the disease course from an inflammatory to a neurodegenerative phenotype.'], ['Over the last two decades, the increase in the incidence of neurodegenerative diseases due to the increasingly ageing population has resulted in a major social and economic burden.', 'This review discusses the characteristics and functions of polyphenols that shape their potential therapeutic actions in neurodegenerative diseases while the less-explored gaps in knowledge of these nutrients will also be highlighted.'], ['CONCLUSIONS: These findings are consistent with previous studies and support the hypothesis that delayed primacy may be a useful cognitive marker of early detection of neurodegeneration.'], ["OBJECTIVES: It has been challenging to identify cognitive markers to differentiate healthy brain aging from neurodegeneration due to Alzheimer's disease (AD) that are not affected by age and education."], ['With ageing of the global society, the frequency of ageing-related neurodegenerative diseases such as Alzheimer`s disease (AD) is on the rise worldwide.', 'In search for a treatment approach of AD, we found that inhibition of the angiotensin-converting enzyme (ACE) by a centrally acting ACE inhibitor retards symptoms of neurodegeneration, Abeta plaque formation and tau hyperphosphorylation in experimental models of AD.', 'Initial evidence with AD patients shows that a brain-penetrating ACE inhibitor counteracts the process of neurodegeneration and dementia.'], ['The results indicate that despite neurodegeneration there is still potential to modify connectivity within and between motor and cognitive networks in response to motor training, although these alterations largely bypass the most affected regions in PD.'], ['These chiropractors were associated with treating degenerative spine conditions (OR [odds ratio] 2.25; 95% [confidence interval] CI 1.72-2.94), working in a non-urban area (OR 1.85; 95% CI 1.35-2.54), treating low back pain (referred/radicular) (OR 1.74; 95% CI 1.26-2.40) and lower limb musculoskeletal disorders (OR 1.50; 95% CI 1.15-1.96).'], ['Our findings represent a model for aSyn toxicity that has important implications for understanding synucleinopathies and other age-related neurodegenerative diseases.'], ["Alzheimer's disease is a widespread type of neurodegenerative dementia that mainly affects the elderly."], ['AIMS: Osteoarthritis (OA) is a chronic and degenerative joint disease prevalent in the elderly, which is characterized by hypertrophy and reactive hyperplasia of articular cartilage.'], ["Parkinson's disease (PD) is known as a progressive neurodegenerative disorder associated with the reduction of dopamine-secreting neurons and the formation of Lewy bodies in the substantia nigra and basal ganglia routes."], ['Aging-related, nonresolving inflammation in both the central nervous system (CNS) and periphery predisposes individuals to the development of neurodegenerative disorders (NDDs).', 'Inflammasomes are thought to be especially relevant to immune homeostasis, and their dysregulation contributes to inflammation and NDDs.', 'In addition, the small molecule kaempferol (Ka) protected mice against LPS- and SNCA-induced neurodegeneration by inhibiting NLRP3 inflammasome activation as evidenced by the fact that Ka reduced cleaved CASP1 expression and disrupted NLRP3-PYCARD-CASP1 complex assembly with concomitant decreased IL1B secretion.', 'These findings were further confirmed in vivo as knockdown of Atg5 expression or autophagy inhibitor treatment significantly inhibited the Ka-mediated NLRP3 inflammasome inhibition and neurodegeneration amelioration.', 'Thus, we demonstrated that Ka promotes neuroinflammatory inhibition via the cooperation of ubiquitination and autophagy, suggesting that Ka is a promising therapeutic strategy for the treatment of NDDs.', ': intraperitoneally; Ka: kaempferol; KD: knockdown; KO: knockout; LPS: lipopolysaccharide; IL1B: interleukin 1 beta; IL6: interleukin 6; Ly: lysate; MAP1LC3B/LC3B: microtubule-associated protein 1 light chain 3 beta; MPTP: 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; NC: negative control; NDD: neurodegenerative diseases; NLRP3: NLR family, pyrin domain containing 3; OE: overexpression; PD: Parkinson disease; poly-Ub: poly-ubiquitin; PTM: post-translational modification; PYCARD/ASC: PYD and CARD domain containing; Rapa: rapamycin; RFP: red fluorescent protein; SN: supernatant; SNCA: synuclein alpha; SNpc: substantia nigra pars compacta; SQSTM1: sequestosome 1; TH: tyrosine hydroxylase; TNF/TNF-alpha: tumor necrosis factor; Ub: ubiquitin; WT: wild type.'], ['Glaucoma is a multifactorial neurodegenerative disease that causes impaired vision and, in advanced cases, blindness.'], ["PURPOSE OF REVIEW: Nutrition is known to modulate the immune system and may alter neuroinflammatory processes implicated in the pathogenesis of Alzheimer's disease (AD) and progression of neurodegeneration."], ['Osteopaths who treated older adults were more likely to treat shoulder musculoskeletal disorders, degenerative spine disorders, chronic or persistent pain, and tendinopathies.'], ['The results demonstrated that the drug abuser group showed a higher expression of miR-132 and miR-34, suggesting a specific pathway in consumption-induced neurodegeneration.'], ["Alzheimer's disease (AD) is a progressive neurodegenerative disease, characterized by memory loss and multiple cognitive impairments."], ["Inflammation is a common process involved in aging, multiple sclerosis (MS), and age-related neurodegenerative disorders such as Alzheimer's disease (AD) and Parkinson's disease (PD), but there is limited evidence for the effects of aging on inflammation in the central nervous system."], ["BACKGROUND: Alzheimer's disease (AD) is a progressive neurodegenerative disease, and due to various physiological and psychological factors the patients are at risk of nutritional insufficiencies."], ['Presently there are no disease-modifying treatments for any of the neurodegenerative dementias.'], ['The most predictive patient characteristics of a risk of death within 6 to 12 months are: deteriorating performance status, weight loss, persistent symptoms, request for palliative care or treatment withdrawal, impaired activities of daily living, falls +- fractured hip, neurological deterioration, advanced lung disease, and estimated glomerular filtration rate <30 mL/min/1.73 m2 with deteriorating health.'], ['Knee osteoarthritis is one of the most common degenerative diseases causing disability in elderly patients.'], ["Neurodegenerative diseases, primarily Alzheimer's disease, are associated with epilepsy, but the pathophysiological links between the two are poorly understood."], ['Whilst age, renal failure, and pre-existing neurological disease were associated with PACU delirium in the univariable analysis, the multivariable analysis revealed the importance of information derived from the EEG, anaesthetic technique, anaesthesia duration, and history of stroke or neurodegenerative disease.'], ["Parkinson's disease (PD) is the second most common neurodegenerative disease in the elderly, which is clinically characterized by bradykinesia, resting tremor, abnormal posture balance, and hypermyotonia."], ['As metabolic dysfunction is linked to human disease, SIRT4 levels and activities have been implicated in modulating susceptibility to hyperinsulinemia and diabetes, liver disease, cancer, neurodegeneration, heart disease, aging, and pathogenic infections.'], ['Cellular senescence causes a proinflammatory cellular phenotype that impairs tissue regeneration, has been linked to stress, and is implicated in several human neurodegenerative diseases.'], ['Human beings are facing emerging degenerative and cancer diseases, in large part, as a consequence of increased life expectancy.'], ['It has been known for years that many neuromuscular and neurodegenerative diseases are associated with overt production of reactive oxygen species (ROSs), a rise in isoprostanes (biomarker of mitochondrial ROSs in urine or blood) and poor calcium (Ca2+) handing.', 'It is also curious, why so many neurodegenerative diseases of known and unknown etiology start at mid-life or later, such as Multiple Sclerosis (MS), Huntington Disease (HD), AD, Parkinson Disease, and Amyotrophic Lateral Sclerosis (ALS).', 'Is it possible that most, if not all neurodegenerative diseases are manifested through mitochondrial dysfunction?', 'DNP will be addressed as a treatment for "metabesity", an emerging term related to the global comorbidities associated with the over-nutritional phenotype; obesity, diabetes, nonalcoholic steatohepatitis (NASH), metabolic syndrome, cardiovascular disease, but including neurodegenerative disorders and accelerated aging.'], ['More research is needed to define the mechanisms underlying AF-related neurodegeneration.'], ['Here, we employed NII measures in conjunction with cerebrospinal fluid (CSF) biomarker classification (for beta-amyloid (Abeta) and neurodegeneration) to evaluate 200 participants in an ongoing study of memory and aging.', 'NII-derived FA also negatively correlated with CSF t-tau level (a marker of neurodegeneration), suggesting that disruption of WM integrity is associated with increasing neurodegeneration.'], ['Findings suggest that cognitive dispersion may be a sensitive marker of neurodegeneration and functional decline in nondemented older adults.'], ['Recent research has focused on the relationship between neurodegeneration and vitamin D, Klotho and homocysteine levels.'], ['Many processes are involved in aging, and neurodegeneration is one of the aging processes in which the central nervous system is engaged.', 'Not all molecular mechanisms associated with age-related neurodegeneration are fully understood; however, there is a whole range of data on the participation of nicotinic acetylcholine receptors in the processes of aging and neurodegeneration.', 'The decrease in nicotinic acetylcholine receptors is also very important for the pathogenesis of age-related neurodegenerative diseases.'], ['Patients with knowndemyelinating white matter disease, neurodegenerative disorders, cerebrovascular event history, or brain tumors were excluded fromthe study.'], ['Mutations in the LMNA gene -encoding for A-type lamins- are associated with over a dozen of degenerative disorders termed laminopathies, which include muscular dystrophies, lipodystrophies, neuropathies, and premature ageing diseases such as Hutchinson Gilford Progeria Syndrome (HGPS).'], ['Many diseases are related to age, among these neurodegeneration is particularly important.', 'These are well known in the case of glaucoma, less in the case of neurodegeneration of the brain.', 'Intracellular and/or extracellular accumulation of protein aggregates is a key feature of many neurodegenerative disorders.', 'Intra-cell catabolic processes also appear to be common in both glaucoma and neurodegeneration.'], ['Aging leads to numerous changes that affect all physiological systems of the body including the immune system, causing greater susceptibility to infectious disease and contributing to the cardiovascular, metabolic, autoimmune, and neurodegenerative diseases of aging.'], ['Fragile X-associated tremor/ataxia syndrome (FXTAS) is a late-onset neurodegenerative disorder that appears in at least one-third of adult carriers of a premutation (55-200 CGG repeats) in the fragile X mental retardation 1 (FMR1) gene.', "Several studies have shown that mitochondrial dysfunction may play a central role in aging and also in neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease, Huntington's disease as well as in FXTAS."], ['Hct-corrected ASL could be potentially important for CBF threshold decision making in the fields of neurodegenerative disease and neuro-oncology.'], ['Similar observations, sometimes implicating other sections of the hippocampus, have been made for aging populations and for people with neurodegenerative diseases that affect the hippocampus.'], ['More recently its role in ageing processes, including neurodegenerative disorders has emerged, although far more research is required in this area, particularly in humans.', 'Epigenetic pathways may strengthen the links between neurodevelopmental disorders and neurodegenerative diseases.', 'WHAT THIS PAPER ADDS: DNA methylation has relevance to both neurological development and neurodegeneration.'], ['However, little is known about relationships between eye diseases and dementia-related neurodegeneration.'], ['Spatial navigation tasks reveal small differences between normal and pathological aging and may thus disclose potential neuropsychological predictors of neurodegenerative diseases.'], ["BACKGROUND: The UNC5C rs3846455G allele has been linked to poor cognitive resilience against age-related neuropathologies, but this association remains to be replicated, and the allele's effect on hippocampal neurodegeneration needs to be examined."], ['Total joint arthroplasty (TJA) is one of the most common and reliable orthopaedic procedures that has significantly improved the quality of life of patients with degenerative joint diseases.'], ['In recent years, there has been a growing interest, supported by a large number of experimental, epidemiological and clinical studies, about the beneficial effects of some natural products in preventing various age-related pathologic conditions, including brain aging and neurodegeneration.'], ["Since our results, it is possible to conclude that during the aging the PFC' cells adopt transcriptional strategies sex-dependent that could potentially control the development of neurodegenerative diseases."], ['AIM: Increased life expectancy causes a higher prevalence of chronic and degenerative diseases, and greater frailty among older people.'], ["However, it remains unclear whether IR undergoes spatial or temporal changes during different stages of aging or neurodegeneration like Alzheimer's disease (AD)."], ["Likewise, degenerative disorders aside from HAND increase with age and there is evidence of shared pathology between HAND and other neurodegenerative diseases, such as Alzheimer's disease, which can occur with or without co-existing HAND."], ['Purpose: Given the aging Chinese population and the inevitable degenerative process of the spine, more elderly patients with spinal degenerative disease (SDD) are surgical candidates, placing a significant burden on health care resources.', 'Few studies have investigated recent trends in hospital admissions and procedures for SDD in China.', 'This study aimed to identify the trends, if any, in the number of surgical procedures undertaken for SDD in a large patient cohort.', 'Results: Altogether, 38,676 surgery records from 37,897 SDD patients who had undergone surgical treatment were included in our study, among whom 49.60%, 47.81%, and 2.59% were treated because of cervical, lumbar, and thoracic degenerative disease, respectively.', 'Conclusion: Our study showed a significantly increasing surgical workload for addressing SDD in China.', 'Both the public and the health care system should be aware of this increase in chronic degenerative disease in the aging population.'], ["The increased levels of iron found in specific brain regions and their potential contribution to neurodegenerative diseases, including Parkinson's disease, Alzheimer's disease, Huntington's disease and other polyglutamine expansion diseases, amyotrophic lateral sclerosis, Friedreich's ataxia, as well as a number of neurodegenerative diseases with iron accumulation, are discussed.", 'The interactions between neuroinflammation and iron are presented, and the chapter concludes with a review of current clinical studies and discussion of the potential and efficacy of iron chelation therapy in the treatment of neurodegenerative diseases.'], ['DISCUSSION: The study showed that adjustable shoulder HA is a safe and effective treatment option for various degenerative disorders of the shoulder joint.'], ["Those with mTBIs and pre-injury neurological conditions had higher NF-L levels than those with no pre-injury neurological conditions (p < 0.001, Cohen's d = 1.01)."], ['OBJECTIVE: To examine the long-term cognitive trajectories of individuals with normal cognition at baseline and distinct amyloid/tau/neurodegeneration (ATN) profiles.', 'METHODS: Pooling data across 4 cohort studies, 814 cognitively normal participants (mean baseline age = 59.6 years) were classified into 8 ATN groups using baseline CSF levels of beta-amyloid 1-42 as a measure of amyloid (A), phosphorylated tau 181 as a measure of tau (T), and total tau as a measure of neurodegeneration (N).', 'RESULTS: Using different model formulations and cut points for determining biomarker abnormality, only the group with abnormal levels of amyloid, tau, and neurodegeneration (A+T+N+) showed consistently greater cognitive decline than the group with normal levels of all biomarkers (A-T-N-).', 'CONCLUSION: The results are consistent with the hypothesis that both elevated brain amyloid and neurofibrillary tangles are necessary to observe accelerated neurodegeneration, which in turn leads to cognitive decline.'], ['The positive impact of long-term exercise training by delaying the onset of physiological memory loss and the associated neurotrophic and redox peripheral modulation, suggests the effectiveness of exercise as preventive strategy against age-related memory loss and neurodegeneration.'], ['Accumulation of mutations in mitochondrial DNA (mtDNA) is thought to be responsible for mitochondrial, and other, diseases and biological phenomena, such as diabetes, cancer, neurodegenerative diseases, and aging.'], ['The mechanisms identified would also occur in other chronic diseases associated with inflammation, aging and some mental and neurodegenerative diseases.'], ['Drug-induced Parkinsonism (DIP) represents the second most-frequent etiology of Parkinson syndromes after neurodegenerative disorders.'], ['Neurodegenerative disorders are an increasingly common and irreversible burden on society, often affecting the aging population, but their etiology and disease mechanisms are poorly understood.', 'Studying monogenic neurodegenerative diseases with known genetic cause provides an opportunity to understand cellular mechanisms also affected in more complex disorders.', 'We recently reported that loss-of-function mutations in the autophagy adaptor protein SQSTM1/p62 lead to a slowly progressive neurodegenerative disease presenting in childhood.'], ["Alzheimer's disease (AD) is a progressive neurodegenerative disease and the most common cause of dementia in the elderly."], ["Parkinson's disease (PD) is a most common progressive neurodegenerative disease mainly occurring in the elderly."], ['Insomnia is the most common sleep disorder among adults, especially affecting individuals of advanced age or with neurodegenerative disease.'], ["BACKGROUND: Decreased levels of the neuroprotective growth factors, low-grade inflammation, and reduced neurocognitive functions during aging are associated with neurodegenerative diseases, such as Alzheimer's disease."], ['Temporomandibular joint (TMJ) osteoarthritis (OA) is a degenerative disease of the joint that can produce persistent orofacial pain as well as functional and structural changes to its bone, cartilage, and ligaments.'], ['This compound has many properties, including activity against glycation, oxidative stress, inflammation, neurodegeneration, several types of cancer, and aging.'], ["Growing evidence suggests that green tea can also be used as a potential agent to mediate neurodegenerative diseases, including Alzheimer's disease."], ['Neurodegenerative disorders are related to the progressive functional loss of the brain, often connected to emotional and physical disability and, ultimately, to death.', "Then, we discuss the state-of-theart of brain-on-a-chip platforms including their role in the study of the functional architecture of the brain e.g., blood-brain barrier, or of the most diffuse neurodegenerative diseases like Alzheimer's and Parkinson's.", 'At last, the current limitations and future perspectives of this approach for the development of new drugs and neurodegenerative diseases modeling will be discussed.'], ['Defects in the UPRmt have been linked to aging and are also associated with neurodegenerative diseases.'], ["Nevertheless, we also considered research with frail older adults and those with age-associated neurodegenerative diseases, such as Alzheimer's and Parkinson's disease, and in a few cases molecular and cellular outcome measures from animal studies."], ['Thus, the compound of peptides AEDG, KE, AED, and KED could promote the neuronal differentiation of hPDLSCs and be a promising tool for the study of peptides as a modulator of neurogenesis in neurodegenerative diseases studied in animal models.'], ['There are a number of mechanisms through which chronic HIV disease alone or in combination with antiretroviral therapy and other comorbidities (e.g., drug use, hepatitis C virus (HCV)) might be contributing to HAND in individuals over the age of 50 years, including (1) overlapping pathogenic mechanisms between HIV and aging (e.g., decreased proteostasis, DNA damage, chronic inflammation, epigenetics, vascular), which could lead to accelerated cellular aging and neurodegeneration and/or (2) by promoting pathways involved in AD/ADRD neuropathogenesis (e.g., triggering amyloid beta, Tau, or alpha-synuclein accumulation).'], ['Although the exact pathophysiology of POCD remains unknown, two possible and reliable mechanisms have been proposed: neuroinflammation and neurodegeneration, i.e., amyloid beta accumulation and/or tau protein phosphorylation, by surgery and/or general anesthetics.'], ["Dysfunction in 24-h circadian rhythms is a common occurrence in ageing adults; however, circadian rhythm disruptions are more severe in people with age-related neurodegenerative diseases, including Alzheimer's disease and related dementias, and Parkinson's disease.", 'Manifestations of circadian rhythm disruptions differ according to the type and severity of neurodegenerative disease and, for some patients, occur before the onset of typical clinical symptoms of neurodegeneration.', "Evidence from preliminary studies suggest that circadian rhythm disruptions, in addition to being a symptom of neurodegeneration, might also be a potential risk factor for developing Alzheimer's disease and related dementias, and Parkinson's disease, although large, longitudinal studies are needed to confirm this relationship.", 'The mechanistic link between circadian rhythms and neurodegeneration is still not fully understood, although proposed underlying pathways include alterations of protein homoeostasis and immune and inflammatory function.', 'Furthermore, clinical trials are needed to determine whether circadian interventions could prevent or delay the onset of neurodegenerative diseases.'], ['However, the role of A-type lamin in neurodegeneration is still obscure.'], ['A decline or loss of sensitivity/responsiveness of autophagy is intimately linked with an accelerated rate of ageing as well as many age-related diseases including neurodegeneration, cancer and metabolic disease where damage accumulation exceeds damage removal.'], ['Our cross-sectional data support the potential role of mushrooms and their bioactive compounds in delaying neurodegeneration.'], ['Corpora amylacea are spherical bodies of unknown origin and function, which accumulate in the human brain during the aging process and neurodegenerative disorders.'], ["Alzheimer's disease represents the most common age-related neurodegenerative disorder and a leading cause of progressive cognitive impairment."], ["Parkinson's disease (PD) is a neurodegenerative disease characterized by alpha-synuclein-positive inclusion bodies and loss of neurons, including dopaminergic neurons.", 'Amelioration of the cell loss by genetic depletion of alpha-synuclein suggests that alpha-synuclein is not a bystander but a causative protein of neurodegeneration.', 'N. furzeri can reveal mechanisms underlying PD, especially of the idiopathic form that affects a majority of patients with PD, including alpha-synuclein-dependent neurodegeneration, age-dependent phenotypes, and progression of alpha-synuclein pathology.'], ['Growing recognition of the pivotal role microglia play in neurodegenerative and neuroinflammatory disorders has accentuated the need to characterize their function in health and disease.'], ['The neurodegeneration process initiates alongside aging of the neurons.', 'Despite common treatments that help to prevent the development of disease, the condition of patients with progressive neurodegenerative diseases usually do not completely improve.', 'Currently, the use of flavonoids, especially quercetin for the treatment of neurodegenerative diseases, has been expanded in animal models.', 'It has also been used to treat animal models of neurodegenerative diseases.', 'The treatment of animal models of neurodegeneration using quercetin-involved nanoparticles has shown that improvements are observed in shorter periods and with use of lower concentrations.'], ['Future precision medicine efforts for molecular targeting of neurodegenerative diseases may require analyses not anchored on current clinicopathologic criteria but instead on biological signals generated from large deeply phenotyped aging populations or from smaller but well-defined genetic-molecular cohorts.'], ['Neurodegenerative disorders affect around one billion people worldwide.', 'A progressive neurodegenerative process and neuroinflammation occur, and no current therapies can prevent, slow, or halt disease progression.', 'Neurodegenerative diseases, like in other age-related disorders, the progression of pathology begins many years before the onset of symptoms.', 'Many efforts in this field have led to the conclusion that exits some similar events among these diseases that can explain why the aging brain is so vulnerable to suffer neurodegenerative diseases.', 'This article reviews the current knowledge about these diseases by summarizing the most common features of major neurodegenerative disorders, their causes and consequences, and the proposed novel therapeutic approaches.'], ['Another distinctive finding was the presence of activated microglia in the ventrolateral region of the aged nigra, suggesting sub-threshold neurodegeneration.'], ["Alzheimer's disease (AD) is the most common neurodegenerative disorder and the primary form of dementia in the elderly.", 'One of the main features of AD is the increase in amyloid-beta (Abeta) peptide production and aggregation, leading to oxidative stress, neuroinflammation and neurodegeneration.', 'These results point to a protective effect of the Arabidopsis extract in AD, and prompt its use as a model in studying the impact of complex mixtures derived from plant-based food on neurodegenerative diseases.'], ["Yet, it can be afflicted by a variety of neurodegenerative diseases specifically linked to aging, about which we lack a full biomolecular understanding of onset and progression, such as Alzheimer's disease (AD).", 'This resource can serve as a guide, as well as a point of reference for how specific regions of the brain are affected by aging and neurodegeneration.'], ["In addition, an association between folate status and ageing, dementia and other neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease and amyotrophic lateral sclerosis is discussed."], ['Neurodegenerative diseases are a very important clinical problem for several reasons.'], ["Parkinson's disease (PD) is an aging-related degenerative disorder arisen from the loss of dopaminergic neurons in substantia nigra."], ['The determination of appropriate dietary strategies for the prevention of chronic degenerative diseases, cancer, diabetes, and cardiovascular diseases remains a challenging and highly relevant issue worldwide.'], ["Interestingly, KEGG analysis revealed these lncRNAs were associated with neurodegenerative disorders such as Alzheimer's disease, Huntington's disease and Parkinson's disease."], ["Late-onset Alzheimer's disease (AD) is a complex age-related neurodegenerative disorder that likely involves epigenetic factors."], ['Osteoarthritis and many age-related degenerative joint diseases are correlated with aging mechanisms such as the presence of an inflammatory microenvironment and the impaired link between inflammasomes and autophagy.', 'The purpose of this review is to summarize the main mechanisms implicated in inflammaging and the connection it has with degenerative joint diseases.'], ['Fludeoxyglucose positron emission tomography (FDG-PET) is a promising imaging modality for diagnosing NPH and detecting concomitant degenerative disease.'], ['Olfaction declines with aging and appears to be a prodromal sign of cognitive decline in progressive neurodegenerative diseases.'], ['Increased understanding of these pathologic entities is important for the neurologist who may encounter patients with an unusually slowly progressive degenerative dementia that may appear to meet criteria for Alzheimer disease but who progress to develop symptoms that are unusual for classic Alzheimer disease RECENT FINDINGS: Hippocampal sclerosis has traditionally been associated with hypoxic/ischemic injury and poorly controlled epilepsy, but it is now recognized that hippocampal sclerosis may also be associated with a unique degenerative disease of aging or may be an associated pathologic finding in many cases of frontotemporal lobar degeneration.', 'SUMMARY: Despite advances in dementia diagnosis that suggest that we have identified and unlocked the mysteries of the major degenerative disease states responsible for cognitive decline and dementia in the elderly, diseases such as hippocampal sclerosis, argyrophilic grain disease, and primary age-related tauopathy demonstrate that we remain on the frontier of discovery and that our diagnostic repertoire of diseases responsible for such clinical symptoms remains in its infancy.'], ['Emerging CSF and imaging biomarkers can now detect the key neuropathologic features of the disease (amyloid plaques, neurofibrillary tangles, and neurodegeneration) in living people, allowing for characterization of patients based on biological measures.'], ['OBJECTIVES: Our objective was to examine whether adherence to the Mediterranean-DASH diet intervention for neurodegenerative delay (MIND) was associated with SMC (as measured by the cognitive difficulties scale; CDS) in the NutriNet-Sante cohort.'], ['Human inflammatory or neurodegenerative diseases, such as progressive multiple sclerosis (MS), occur on a background of age-related microglia activation and iron accumulation as well as pre-existing neurodegeneration.', 'Most experimental models for CNS diseases, however, are induced in rodents, which are naturally characterized by a homeostatic microglia phenotype, low cellular iron load and absence of neurodegeneration.'], ['The increase in life expectancy associated with the increase in chronological age and less active people helps in the appearance of chronic and degenerative diseases.'], ['However, postoperative decompensation of an unknown cerebral condition due to the pathophysiology of cirrhosis or undiagnosed neurodegenerative disorders or aging constitute other possibilities that are underrecognized.'], ["Mitochondrial dysfunction is a key feature in both aging and neurodegenerative diseases including Alzheimer's disease (AD), but the molecular signature that distinguishes pathological changes in the AD from healthy aging in the brain mitochondria remain poorly understood."], ['In the present study, a database was conceived for the straightforward retrieval of information on genes involved in skeletal muscle formation, neuromuscular diseases (NMDs), ageing, and neurodegenerative disorders (NDs).', 'The authors believe NeuroMuscleDB provides a platform for obtaining desired information on genes related to myogenesis and their associations with various diseases (NMDs, ageing, and NDs).'], ["It's widely acknowledged that, as a neurodegenerative aging disease representing an intermediate stage between cognitive intactness and Alzheimer's disease (AD), Mild cognitive impairment (MCI) poses an excessive burden on patients' well-being, family members, health-care providers as well as the whole society."], ['BACKGROUND: Given the increasing lifespan of the elderly and the higher proportion of older people in the global population, the incidence rate of neurodegenerative diseases is increasing.'], ['Identifying microglia subpopulations based on their morphology and molecular markers may ultimately help decipher their function and role in neurodegeneration.'], ['PURPOSE: Understanding the healthy brain aging process is key to uncover the mechanisms that lead to pathologic age-related neurodegeneration, including progression to Alzheimer disease (AD).', 'TECPR2 and CINP appear to be "partner" genes in terms of regulation and their associated transcription factors have been previously implicated in AD and neurodegeneration.'], ["Numerous studies on aging-related brain diseases show that some genes identified as risk factors for some of the most common neurodegenerative diseases - such as the allele 4 of APOE gene (APOE4) for Alzheimer's disease (AD) - have a much earlier neuro-anatomical and neuro-physiological impact.", 'The APOE4, an allele classically associated with later-life neurodegenerative disorders as AD, seems in fact to exert a series of very early effects on phenomena of neuroplasticity and synaptogenesis that begin from the earliest periods of life such as the fetal ones.We reviewed some of the findings supporting the hypothesis that APOE polymorphism is an early modifier of various neurobiological aspects across the entire human lifespan - from the in-utero to the centenarian life - during both normal and pathological conditions of the brain.'], ["The drug rapamycin has beneficial effects in a number of animal models of neurodegeneration and aging including mouse models of Alzheimer's disease."], ['These findings present an important baseline from which to assess divergence from normative aging trends in developmental and degenerative disorders, and to further investigate the mechanisms connecting WM microstructure to cognition.'], ['The term comorbidity is used here to distinguish cases with overlapping pathogenic mechanisms, which includes combinations of neurodegenerative proteinopathies from cases with multimorbidity, which is defined as concomitant brain and systemic disorders with different pathogenic mechanisms.', 'This corroborates elucidation of various pathogenic pathways leading to neurodegeneration.'], ["Neurocognitive complications, typically known as HIV-associated neurocognitive disorders (HAND), persist in the era of ARVs and, in addition to risk of HAND, older PWH are also at risk for age-associated, neurodegenerative disorders including Alzheimer's disease (AD)."], ['Epigenetic dysregulation, which leads to the alteration of gene expression in the brain, is suggested as one of the key pathophysiological bases of ageing and neurodegeneration.', "These results suggest that disrupted epigenetic regulation of glutamate receptor transcription underlies the synaptic and cognitive deficits in Alzheimer's disease, and targeting histone methylation enzymes may represent a novel therapeutic strategy for this prevalent neurodegenerative disorder."], ["However, aging is also the primary driver of the dominant human diseases, such as cardiovascular disease, cancer, and neurodegenerative diseases, including Alzheimer's disease."], ["Parkinson's disease is a progressive neurodegenerative disorder of aging."], ['Structural brain markers are studied extensively in the field of neurodegeneration, but are thought to occur rather late in the process.', 'Functional measures such as functional connectivity are gaining interest as potentially more subtle markers of neurodegeneration.', 'More information is needed on how functional connectivity relates to aging, particularly in the absence of overt neurodegenerative disease.', 'Our results reinforce the notion that the aging brain undergoes a reorganization process, and serves as a solid basis for exploring functional connectivity as a preclinical marker of neurodegenerative disease.'], ['CONCLUSIONS: Given the aging population and increasing numbers of patients with memory impairment from neurodegenerative diseases, interest in neuromodulation for memory enhancement will likely expand.'], ['OBJECTIVE: We aimed to examine whether impaired olfaction is associated with cognitive decline and indicators of neurodegeneration in the brain of dementia-free older adults.', 'CONCLUSION: Impaired olfaction predicts faster cognitive decline and might indicate neurodegeneration in the brain among dementia-free older adults.'], ['CR also improves healthspan by preventing the development of various aging-related diseases such as cancer, cardiovascular disease, diabetes, and neurodegeneration.'], ["BACKGROUND: Neurodegenerative diseases are becoming more and more common in today's world.", 'Even though some amount of oxidative damage occurs in all metabolic reactions but their increase from the normal level in organisms causes neurodegenerative diseases.', 'These neurodegenerative disorders like Alzeimers, Parkinsons disease and neuropsychiatric disorders such as schizophrenia, bipolar, depression are caused due to the decline in physiological and psychological functions caused by ROS and RNS.', 'Further, it explains the pathways of neurodegenerative diseases and neuropsychiatric diseases.', 'CONCLUSION: It is clear that neurodegenerative diseases are caused due to excess oxidative stress and alter the functioning of the central nervous system.', 'The central nervous system undergoes neurodegenerative or neuropsychiatric changes.'], ['In particular, a disturbance in the regulation of copper (Cu), characterized by an increase in circulating Cu not bound to ceruloplasmin (non-Cp Cu), is thought to play a role in the development of Alzheimer disease (AD) and other neurodegenerative diseases in the aging population.'], ['Models of the human brain as a complex network of inter-connected sub-units are important in helping to understand the structural basis of the clinical features of neurodegenerative disorders.', 'Although lobar modularity is preserved in the context of neurodegenerative disease, the hub-like organization of networks differs both from normal and between the two forms of dementia.', 'This implies that hubs may be secondary features of the connectivity adaptation to neurodegeneration and may not be an intrinsic property of the brain.'], ['PURPOSE: To present a standardized protocol for multicentric research on dementia linked to neurodegeneration in aging, harmonized on all three major vendor platforms.', 'DATA CONCLUSION: The harmonized Canadian Dementia Imaging Protocol suits the needs of studies that need to ensure quality MRI data acquisition for the measurement of brain changes across adulthood, due to aging, neurodegeneration, and other etiologies.'], ['Neurodegenerative diseases are incurable debilitating disorders characterized by structural and functional neuronal loss.', "Neurodegenerative disorders include Alzheimer's, Parkinson's, and prion diseases among others.", 'While it is widely accepted that aging represents the main risk factor for neurodegeneration, there is still no clear cut-off line between the two conditions.', 'Indeed, many of the pathways that are commonly altered in neurodegeneration-misfolded protein accumulation, chronic inflammation, mitochondrial dysfunction, impaired iron homeostasis, epigenetic modifications-have been often correlated also with healthy aging.', 'When a given threshold is exceeded, all these alterations might give rise to pathological phenotypes that ultimately lead to neurodegeneration.'], ["Due to O-GlcNAc's fundamental roles as a nutrient and stress sensor, it plays an important role in the etiologies of chronic diseases of aging, including diabetes, cancer, and neurodegenerative disease."], ['As aging is characterized by neuroinflammation and neurodegeneration, we further evaluated the role of RR against LPS-induced neuroinflammation.'], ['Manufacture of these day-to-day foods involves extreme temperatures on processing results in the formation of AGEs could independently promote oxidative stress, aging, diabetes, cancer, degenerative diseases, more fascinatingly hormonal disruption is the subject of interest of this review.'], ['METHODS: Patients aged 70 years or more undergoing primary isolated elective mitral valve repair or mitral valve replacement for degenerative disease were obtained from the STS ACSD versions 2.73 and 2.81.'], ['To better understand the word recognition process in aging and in neurodegenerative disorders such as MCI and AD, we investigated the nature of the activation of morphologically related family members in 22 Finnish speakers with AD, 24 with MCI, and 17 cognitively healthy elderly.'], ['Such advances for neurological and neurodegenerative diseases are hindered by the lack of similar specimens.'], ["Advanced Glycation End-Products (AGEs) are created in the last step of protein glycation and can be a factor in aging and in the development or worsening of many degenerative diseases (diabetes, chronic kidney disease, atherosclerosis, Alzheimer's disease, etc.)."], ['However, even though neurodegenerative dementia results in the gradual loss of decision-making capacity, ACP is still extremely rare.'], ["Parkinson's disease (PD) is the second most common neurodegenerative disease in the world.", 'This latent stage of neurodegeneration in PD is a particularly important stage for effective neuroprotective therapies, which might retard the progression or prevent the onset of PD.'], ['There is considerable interest in the pathobiology of tau protein, given its potential role in neurodegenerative diseases and aging.', 'Tau haplotypes confer differing susceptibility to neurodegeneration.', 'Tau may be hyperphosphorylated, and may aggregate as detectable fibrillar deposits in tissues, in both aging and neurodegenerative disease.', 'However, there is extensive overlap, not only between genuine neurodegenerative diseases, but also between aging and disease.', 'The diagnostic process for tauopathies and neurodegenerative diseases in general is challenging in many respects, and may be particularly problematic for postmortem evaluation of former athletes and military service members.'], ['KP metabolites have been involved in the aging process and neurodegenerative diseases.'], ['We investigated predictors of neurodegeneration, measured by MRI-based volume loss, in older adults before diagnosis of cognitive impairment.'], ['Accordingly, we propose evaluating the well-recognized biomarkers of vascular aging (i.e., the leukocyte telomere length and telomerase activity, and reduced levels of endothelial progenitor cells [EPCs]) with RDW, for predicting the risk for vascular aging and onset and prognosis of age-related degenerative arterial diseases, such as sporadic ascending aorta aneurysm (AAA), characterized to have an increased incidence in old people.'], ['Amyotrophic lateral sclerosis (ALS) is a relentlessly progressive neurodegenerative condition that is invariably fatal, usually within 3 to 5 years of diagnosis.', 'Therefore, although iPSC models recapitulate some disease hallmarks, a crucial challenge is to address the disparity between the advanced age of onset of neurodegenerative diseases and the fetal-equivalent maturational state of iPSC-derivatives.'], ['Most intractable tissue-degenerative disorders share a common pathogenic condition, so-called proteinopathy.'], ['BACKGROUND: High literacy levels are believed to partially counteract the negative effects of neurodegenerative diseases.'], ["BACKGROUND: Impairments of postural stability occur with increasing age and in neurodegenerative diseases like the Parkinson's disease (PD)."], ['CONCLUSIONS: Nowadays, the profiles of hospitalized patients with VHD are dominated by the elderly, with degenerative disease and multiple comorbidities, presenting with HF, AF and LV remodeling, who frequently undergo valve intervention, usually via a percutaneous approach.'], ['Genotoxins are also involved in the pathogenesis of several chronic degenerative diseases, including hepatic, neurodegenerative, and cardiovascular disorders; diabetes; arthritis; cancer; chronic inflammation; and ageing.'], ["This 3-year brain imaging study examines the impact of the menopausal transition on Alzheimer's disease (AD) biomarker changes [brain beta-amyloid load via 11C-PiB PET, and neurodegeneration via 18F-FDG PET and structural MRI] and cognitive performance in midlife.", 'Older age was associated with baseline Abeta and neurodegeneration markers, but not with rates of change in these biomarkers.'], ['Chronic degenerative disease of the vertebral column often occurs in pilots exposed to high flight acceleration forces, thus resulting crucial for Air Force Academy to exclude vertebral disease in cadets.'], ['MAIN BODY: Focusing on the impact of common chronic diseases (comorbidities) in aging on pressure ulcers (e.g., cardiovascular diseases, diabetes, chronic pulmonary diseases, renal diseases and neurodegenerative disorders) and the significant complicating conditions e.g., anemia, infectious diseases, malnutrition, hospitalization, incontinence and polypharmacy, frailty and disability becomes important in developing a more complete, inclusive and multidisciplinary approach to prevention of PU in older patients.'], ["Alzheimer's disease (AD) is a neurodegenerative disorder that drastically compromises patients' and relatives' quality of life, besides being a significant economic burden to global public health."], ['These data provide a novel TAp73-dependent target which might have implications in ageing-related diseases such as cancer and neurodegeneration.'], ['To discover protein markers and speed up diagnosis of neurodegenerative diseases accompanied by protein aggregation, proteomic tools have increasingly been used in recent years.'], ["INTRODUCTION: Alzheimer's pathology is a neurodegenerative disease characterized by cognitive impairment and functional disability that causesprogressive restrictions in daily activities."], ['B4GALNT1 is an enzyme essential for the synthesis of complex gangliosides, whose absence leads to progressive neurodegeneration with aging in mice.'], ['All together, these findings link important stem cell regulators like Bmi1/Usp16 and Cdkn2a to Wnt signaling, and have implications for designing therapies for conditions, like DS, aging or degenerative diseases, where the Wnt pathway is hampered.'], ['The functional and structural brain networks are damaged in neurodegenerative diseases.'], ['BACKGROUND: Advancements in the management of human immunodeficiency virus (HIV) now permit HIV-positive patients to have longer life spans, increasing their cumulative risk of developing an advanced degenerative joint disease, necessitating total hip arthroplasty (THA).'], ["Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder caused by a polyglutamine expansion mutation in the huntingtin protein."], ['In this study, we examined the association of a diet specifically developed to promote brain health, called MIND (Mediterranean-DASH Diet Intervention for Neurodegenerative Delay), to the incidence and progression of parkinsonism in older adults.'], ['The inclusion of regions outside the ventricles allowed specificity from atrophic neurodegenerative diseases that are also accompanied by ventricular enlargement.'], ["Alzheimer's disease (AD) is a progressive neurodegenerative disease that represents a major cause of death in many countries."], ['We thus made calcium homeostasis the starting point of our studies, proposing the notion that the consequences of long-term deficiency and/or inefficient utilization of vitamin D may cause the disruption of calcium homeostasis in neurons, this creating a vulnerability of neurons to aging and neurodegeneration.'], ['In humans, methionine oxidation of critical proteins and deficiencies in the methionine sulfoxide reductase system have been linked to age-related diseases, including cancer and neurodegenerative disease.'], ["Alzheimer's disease (AD) is the most prevalent neurodegenerative disorder in the elderly population.", 'Several recent studies demonstrated that food intake-lowering (anorexigenic) peptides have the potential to improve metabolic disorders and that they may also potentially be useful in the treatment of neurodegenerative diseases.'], ['Arterial spin-labeling is a technique to measure cerebral blood flow and is more sensitive than regional volume loss in assessing neurodegenerative diseases and cognitive aging.'], ['MEASUREMENTS: We defined an abnormal (high) 11 C-PiB-PET retention ratio as a standardized uptake value ratio greater than 1.42 (high amyloid; A+), abnormal (reduced) AD signature cortical thickness (neurodegeneration; N+) as less than 2.67 mm (MRI measurement), and biomarker groups according to the combination of abnormality (or not) for amyloid accumulation (A+/A-) and neurodegeneration (N+/N-).'], ['Alzheimer disease (AD), which is associated with chronic and progressive neurodegeneration, is the most prevalent cause of dementia linked to aging.'], ['These particles also appear to play an important role in neurodegenerative diseases of the brain.', 'Thus, our findings allow in-vivo measurement of magnetite in the human brain, and possibly open the door for new studies of neurodegenerative diseases of the brain.'], ['Our findings suggest that BDNF Val66Met and sex should be considered in future endeavors aimed at treating or preventing neurodegenerative disorders.'], ["Alzheimer's disease (AD), a progressive brain disorder, is the most common neurodegenerative disease in older adults."], ['Other useful applications have been demonstrated for patients with heart or neurodegenerative diseases.'], ['INTRODUCTION: Osteoarthritis (OA) is the most common degenerative joint disease in the elderly.'], ['It is a chronic neurodegenerative disease caused by defected folding and aggregation of amyloid beta (Abeta) protein.'], ['Huntington disease (HD) is an autosomal dominant neurodegenerative disorder characterized by motor, behavioral, and cognitive manifestations.', 'Better appreciation of heterogeneous clinical phenomenology and immediate tractable treatment goals coupled with advances in new therapeutics heralds a golden age of HD treatment that will positively impact quality of life and longevity of HD patients and inform advances in other inherited and neurodegenerative neurological disorders.'], ['Importance: Accumulating data suggest that elevated cerebrospinal fluid (CSF) neurofilament light (NfL) and neurogranin (Ng) levels are associated with cognitive decline and may be useful markers of neurodegeneration.'], ['Disrupted sleep is a contributing factor to cognitive ageing, while also being associated with neurodegenerative disorders.'], ["It is a neurodegenerative disorder that is clinically characterized by a slow progressive amnestic mild cognitive impairment similar to Alzheimer's disease."], ["Neurodegenerative diseases (NDs), including Alzheimer's disease (AD) and Parkinson's disease (PD), threaten the health of an ever-growing number of older people worldwide; so far, there are no effective cures.", 'Significant efforts have been devoted to developing new drugs for NDs in recent years, and some small molecules have been shown to be promising in preclinical studies.', 'Here, we summarize recent advances in the brain-targeting liposomal delivery of small hydrophobic molecules (SHMs) and propose strategies for developing liposomal SHMs as disease-modifying neurotherapeutics for NDs.'], ['BACKGROUND: TDP-43 has been identified as a disease-associated protein in several chronic neurodegenerative disorders and increasing evidence suggests its potentially pathogenic role following brain injuries.', 'Importantly, unlike the hallmark neuropathological features associated with chronic neurodegenerative disorders, the TDP-43-positive cytoplasmic inclusions detected after stroke were not phosphorylated.'], ['We quantified markers of cerebrovascular disease (white matter hyperintensities [WMH], presence of infarct, and presence of microbleed) and neurodegeneration (entorhinal cortex volume) and compared them across groups.'], ['Adequate treatment of anxiety symptoms could have a beneficial influence on the risk of developing neurodegenerative diseases.'], ['However, the mechanisms underlying this association with cognitive dysfunction, either through cerebrovascular disease or neurodegeneration, remain poorly understood.', 'We aimed to examine the association of decreased haemoglobin levels with markers of cerebral small vessel disease (CSVD), neurodegeneration and cognitive impairment in an elderly Asian population.'], ['Increased life expectancy impacts directly on the number of older people worldwide with the associated increase in neurodegenerative diseases.'], ["Alzheimer's disease (AD) is a complex neurodegenerative disease and the most common cause of dementia among the elderly."], ['Decline in age- associated cellular functions leads to neurodegeneration and cognitive decline that affect the quality of life.', 'Moreover, approximately 50% of people, aged 65 years and older develop hypertension and are at a high risk of developing cardiovascular insufficiency and incurable neurodegenerative disorders.'], ['BACKGROUND: Dietary habits have become the focus of intensive research in cognitive aging and neurodegenerative diseases, showing potential to promote and maximize cognitive function.'], ['Variation in transmembrane protein 106B (TMEM106B) has been associated with enhanced neuroinflammation during aging and with TDP-43-related neurodegenerative disease, and rs3173615, a missense coding SNP in TMEM106B, has been implicated as a functional variant in these processes.', 'Eighty-six deceased male athletes with a history of participation in American football, informant-reported Caucasian, and a positive postmortem diagnosis of CTE without comorbid neurodegenerative disease were genotyped for rs3173615.'], ['Although cognitive impairment is also frequent during and after depressive episodes, it may occur irrespective of age, which makes it difficult to determine, whether this symptom indicates a risk for or shared mechanisms with neurodegeneration.', 'Complementing research methods and investigations across the life span would be necessary to reveal possible interactions between risk factors for dementia, neurodegeneration, depression, and age.'], ['Cognitive impairment is a common neurodegenerative disease in the elderly.'], ['This study shows that ACMSD is a key regulator of mammalian dietary niacin requirements and NAD+ metabolism and that the ANDY mouse represents a versatile platform for investigating pathologies linked to low NAD+ levels in aging and neurodegenerative diseases.'], ["This hypothesis explains such well-known phenomena as inverse comorbidity of either cancer or Alzheimer's (AD) and other neurodegenerative diseases; higher AD morbidity and lower frequency of many common types of cancer in women vs. men; higher risk of early AD and lower risk of cancer in subjects with Down syndrome; longer life expectancy in women vs. men and much lower sex-dependent differences, if any, in other mammals; increased lifespans due to hypophysectomy or PG hypofunction; and parabiotic effects of blood or plasma transfusions between young and old animals."], ['Protection of neurons against oxidative stress is crucial during neuronal development, maintenance and for treating neurodegenerative diseases.', 'Our findings are in accordance with the increasing evidences pointing towards sex-specific differences in risk and severity of neurodegenerative diseases.'], ['Inherited mitochondrial DNA (mtDNA) diseases were discovered 30 years ago, and their characterization has provided a new perspective on the etiology of the common metabolic and degenerative diseases, cancer, and aging.'], ['In this review, we discuss the main aspects of hypothalamic alterations in AD, the association between interrupted sleep and neurodegeneration, and the possible therapeutic effect of melatonin on these processes.'], ['Conclusions- Vascular growth factors are associated with early MRI markers of small vessel disease and neurodegeneration in middle-aged adults.'], ["Alzheimer's disease (AD) is the most common neurodegenerative disorder in the elderly, which is characterized by the accumulation of amyloid beta (Abeta) plaques, oxidative stress, and neuronal loss."], ['Importantly, the findings indicate that theories of aging and neurodegenerative diseases should take absolute time lived besides relative "age" into consideration.'], ["INTRODUCTION: Aging is the primary risk factor for major human pathologies, including cancer, diabetes, cardiovascular diseases, and neurodegenerative diseases such as Alzheimer's Disease (AD).", 'AD is a progressive degenerative disorder of the brain and is the most common form of dementia.'], ['They are thought to be closely related to some aging diseases such as cardiovascular disorders, neurodegeneration, and tumors.'], ['As such, PlsEtn deficiency may be pathologically relevant in some neurodegenerative disorders such as AD.'], ['Frontal cortical dysfunction is a fundamental pathology contributing to age-associated behavioral and cognitive deficits that predispose older adults to neurodegenerative diseases.'], ['Beta-propeller protein-associated neurodegeneration (BPAN) arises in infancy and is due to mutations in the WDR45 gene on the X chromosome.', 'Because BPAN is a neurodegenerative disease that can cause immobility, a history of BPAN in patients of all ages may be associated with an increased risk of developing ischemic fasciitis.'], ['These results stress the need of defining scoring scales specifically designed for speech disability estimation and monitoring methodologies in degenerative diseases of neuromotor origin.'], ['The application of natural history data can stratify atraumatic degenerative tears according to the risk of nonsurgical treatment and better identify tears where early surgical intervention should be considered.'], ['Limited efficacy of current therapeutic approaches for neurodegenerative disease has led to increased interest in alternative therapies.', "Also, our novel finding that autologous CBP promoted MNC hUCB viability and reduced apoptotic cell death in vitro supports CBP's potential as a sole therapeutic or cell-additive agent in developing therapies for various neurodegenerative diseases."], ['However, data are lacking on the association of BSO before menopause with imaging biomarkers that indicate medial temporal lobe neurodegeneration and Alzheimer disease pathophysiology.', 'White matter hyperintensity volume and biomarkers for medial temporal lobe neurodegeneration (eg, amygdala volume, hippocampal volume, and parahippocampal-entorhinal cortical thickness) on structural MRI and entorhinal white matter fractional anisotropy on diffusion tensor MRI were also measured.'], ['Mitochondrial-derived peptides (MDPs) are rapidly emerging therapeutic targets to combat development of neurodegenerative diseases.'], ['Complex human diseases, including diabetes, obesity, fatty liver disease and aging-related degenerative diseases are associated with alterations in mitochondrial oxidative phosphorylation (OxPhos) function.'], ["Human-induced Pluripotent Stem Cell (hiPSC)-derived models have advanced the study of neurodegenerative diseases, including Parkinson's disease (PD)."], ["BACKGROUND: Neurological disorders are now the leading source of disability globally, and ageing is increasing the burden of neurodegenerative disorders, including Parkinson's disease."], ['The viral envelope protein gp120 has been identified as a potent neurotoxin affecting neurodegeneration via indirect and direct mechanisms involving interactions with chemokine co-receptors CCR5 and CXCR4.', 'This short review focuses on gp120 neurotropism and associated mechanisms of neurotoxicity linked to chemokine receptors CCR5 and CXCR4 with a new perspective on plasma membrane lipid rafts as an active participant in gp120-mediated neurodegeneration underlying HIV induced CNS pathology.'], ['This regulatory connection between NRF2 and AMPK may have an important role in understanding how autophagy is regulated in chronic human morbidities characterized by oxidative stress, such as neurodegenerative diseases, certain cancer types, and in metabolic diseases.-Kosztelnik, M., Kurucz, A., Papp, D., Jones, E., Sigmond, T., Barna, J., Traka, M. H., Lorincz, T., Szarka, A., Banhegyi, G., Vellai, T., Korcsmaros, T., Kapuy, O. Suppression of AMPK/aak-2 by NRF2/SKN-1 down-regulates autophagy during prolonged oxidative stress.'], ['HTRA1 is a potentially effective target for neuroprotective therapy of early AMD and other degenerative diseases of PRCs.'], ['Technologies for imaging the pathophysiology of Alzheimer disease (AD) now permit studies of the relationships between the two major proteins deposited in this disease - amyloid-beta (Abeta) and tau - and their effects on measures of neurodegeneration and cognition in humans.', 'Despite a strong link between Abeta and tau, the relationship between Abeta and neurodegeneration is weak; rather, it is tau that is associated with brain atrophy and hypometabolism, which, in turn, are related to cognition.', 'Although there is support for an interaction between Abeta and tau resulting in neurodegeneration that leads to dementia, the unknown nature of this interaction, the strikingly different patterns of brain Abeta and tau deposition and the appearance of neurodegeneration in the absence of Abeta and tau are challenges to this model that ultimately must be explained.'], ['Reactive oxygen species and oxidative stress are closely associated with various pathologies such as neurodegenerative diseases, ageing and male infertility.'], ['The field of neurodegenerative disease research has seen tremendous advances over the last two decades as new technologies and analytic methods have enabled well-powered human genomic studies.'], ['Dementia is one neurodegenerative syndrome with potential to compromise capacity for remaining engaged in paid employment.'], ['Neurodegenerative diseases cause progressive loss of cognitive and/or motor function and pose major challenges for societies with rapidly aging populations.', 'Human genetics studies have shown that disease-causing rare mutations and risk-associated common alleles overlap in different neurodegenerative disorders.'], ['Theses reviewed in this issue include "Computational Pathology for Quantifying Spatial Heterogeneity in Digital Images of Tissue Sections from Solid Tumors," "Molecular Analysis of Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration Brain Tissue Identifies Disease Mechanisms Associated with Repetitive DNA Elements," "Neuroprotective Potential of the N-Terminal Beta Amyloid Peptide Fragment in the Neurodegeneration, Synaptic Dysfunction and Memory Deficits in Models of Alzheimer\'s Disease," "pH-triggered Self-Assembly of a PEGylated Peptide Amphiphilic Contrast Agent," "Quantitative Approaches for Profiling the T Cell Receptor Repertoire in Human Tissues," and "Regulation and Repair of Neural Stem Cells and the Neurogenic Niche."'], ['The results of our study suggest that DTBM could be a powerful tool for detecting morphological changes of specific white matter pathways in normal brain development and aging, as well as in degenerative disorders.'], ['We examined the relations of the Mediterranean, Dietary Approaches to Stop Hypertension (DASH), and Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) diets to functional disability in the Rush Memory and Aging Project.'], ['As the number of people living with dementia increases, so too will the financial burden these debilitating and degenerative diseases place on private and public resources.'], ['Among mTOR inhibitors, everolimus, which has been developed to improve the pharmacokinetic characteristics of rapamycin, has been extensively profiled in preclinical and clinical studies as anticancer and immunosuppressive agent, but no information is available about its potential effects on neurodegenerative disorders.'], ['Mounting evidence suggests that humanin and other mitochondrial derived peptides play a role in several age-related conditions including neurodegenerative disease.'], ["Alzheimer's disease (AD) is a worldwide progressive neurodegenerative disorder in the elderly."], ['An emerging role of the peroxisome has been identified in many types of diseases, including cancer, neurodegenerative disorders, aging, obesity, and diabetes.'], ['Finally, we discuss how fluoxetine or running are effective in counteracting depression originated from stress or neurodegenerative diseases.'], ['Because it lacks the ability of regeneration, age is a major risk factor for most common neurodegenerative diseases, which caused an irreversible cognitive impairment.'], ["ApoE expression regulation and apoE gene polymorphism have an important connection with neurological or neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's disease (PD), ischemic stroke, and other diseases."], ['OBJECTIVE: To explore the differential associations of neurodegeneration and microvascular lesion load with cognitive decline and dementia in older people and the modifying effect of the APOE genotype on these associations.', 'At baseline, we assessed microvascular lesion load using a summary score for MRI markers of lacunes, white matter hyperintensities (WMHs), and perivascular spaces and neurodegeneration load for markers of enlarged ventricles, smaller hippocampus, and smaller gray matter.', 'Per 1-point increase in microvascular lesion and neurodegeneration score (range 0-3) was associated with multiple adjusted beta-coefficients of -0.35 (95% confidence interval, -0.51 to -0.20) and -0.44 (-0.56 to -0.32), respectively, for the MMSE score and multiple adjusted hazard ratios of 1.68 (1.12-2.51) and 2.35 (1.58-3.52), respectively, for dementia; carrying APOE epsilon4 reinforced the associations with MMSE decline.', 'WMH volume changes during the follow-up mediated 66.9% and 12.7% of the total association of MMSE decline with the baseline microvascular score and neurodegeneration score, respectively.', 'CONCLUSIONS: Both cerebral microvascular lesion and neurodegeneration loads are strongly associated with cognitive decline and dementia.'], ['MATERIAL AND METHODS: We queried the Arizona Study of Aging and Neurodegenerative Disorders (AZSAND) database for dementia cases with AD pathology (1997-2015).'], ["BACKGROUND: Alzheimer's disease (AD) is a progressive neurodegenerative disorder with a high prevalence among the elderly and a huge personal and societal impact."], ["BACKGROUND: Parkinson's disease (PD) is a neurodegenerative disorder which mainly affects the elderly population of various societies."], ['The selective removal of undesired or damaged mitochondria by autophagy, known as mitophagy, is crucial for cellular homoeostasis, and prevents tumour diffusion, neurodegeneration and ageing.'], ['Alzheimer disease (AD) is a progressive neurodegenerative disorder associated with aging and characterized pathologically by the presence of senile plaques, neurofibrillary tangles, and neurite and synapse loss.'], ['Here, we review advances in exploring age-associated neurodegenerative diseases using human cell reprogramming models, and we discuss general concepts, promises, and limitations of the field.'], ['METHODS: Positron emission tomography brain amyloid load, neurodegeneration (hippocampus and basal forebrain volumes adjusted to total intracranial volume, cortical thickness, and 2-deoxy-2-[fluorine-18]fluoro-D-glucose-positron emission tomography metabolism), and brain resting-state functional connectivity were analyzed in 318 cognitively intact older adults from the INSIGHT-preAD cohort (female n = 201, male n = 117).'], ['It also participates in cancer, neurodegenerative disorders, aging and innate immune defense.'], ["Epidemiological studies show that NNMT is a risk factor for psychiatric diseases like schizophrenia and neurodegeneration, especially Parkinson's disease (PD), but its neuronal mechanisms of action remain obscure.", 'In summary, we provide fundamental insights into neuronal NNMT/ANMT-1 as pivotal regulator of behavior, neurodegeneration, and lifespan by controlling neuronal autophagy, potentially influencing PD and schizophrenia risk in humans.'], ["BACKGROUND: Alzheimer's disease (AD) is a chronic neurodegenerative disease with pathological hallmarks including the formation of extracellular aggregates of amyloid-beta (Abeta) known as plaques and intracellular tau tangles."], ['Advanced age-related macular degeneration (AMD), the leading cause of blindness among people over 50 years of age, is characterized by atrophic neurodegeneration or pathologic angiogenesis.', 'Subretinal deposits in these mice progressively worsen with age, with concomitant accumulation of cholesterol metabolites including several oxysterols and cholesterol esters causing lipotoxicity that manifests as photoreceptor dysfunction and neurodegeneration.'], ['During the last decade, spectroscopic techniques have shown great promise in the robust diagnosis of various pathologies, including neurodegenerative diseases and dementia.'], ['The importance of these connections is highlighted by disease models of both cancer and neurodegeneration, in which compromised DNA repair machinery leads to profound defects in protein quality control, and vice versa.'], ['In this way only, we can effectively contribute to challenge one of the important and actual social issue: the prevention of global exhaustion of caregivers of people with neurodegenerative disease.'], ['The specific autophagy responsible for removal of damaged mitochondria (mitophagy) and mitochondrial dynamics constitute neuronal mitochondrial quality control mechanisms and are impaired in neurodegenerative disorders and numerous other diseases.'], ['The Ibadan Brain Ageing, Dementia And Neurodegeneration (IBADAN) Brain Bank, the first organized brain tissue biorepository in sub - Saharan Africa, is set up to accrue, process and store unique brain tissues for future research into a broad spectrum of neurological and psychiatric disorders.'], ['Functional and cognitive outcomes in AD represent probable interactions between effects of brain reserve and cerebral perfusion over neurodegeneration.'], ['Insufficient or dysregulated energy metabolism may underlie diverse inherited and degenerative diseases, cancer, and even aging itself.'], ['Aging is a major risk factor for both genetic and sporadic neurodegenerative disorders.', 'However, it is unclear how aging interacts with genetic predispositions to promote neurodegeneration.', 'Here, we investigate how partial loss of function of TBK1, a major genetic cause for amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) comorbidity, leads to age-dependent neurodegeneration.'], ['The multiple connections between sphingolipids and IIS signaling suggest possible engagement of these compounds in the aging process itself, which creates a vulnerable background for the majority of neurodegenerative disorders.'], ["Parkinson's disease is a progressive neurodegenerative disease increasingly affecting our aging population."], ['BACKGROUND: Cerebral blood flow (CBF) is an emerging biomarker for normal aging and neurodegenerative diseases.'], ["Parkinson's Disease (PD) is a neurodegenerative and debilitating disease that affects 1% of the elderly population.", 'The substituted xanthine molecule is used as a scaffold for the synthesis of new compounds with protective effects in neurodegenerative diseases, including PD, asthma, cancer and others.'], ['Aging is characterized by progressive memory decline that can lead to dementia when associated with neurodegeneration.', 'Regulation of miR-183/96/182 biogenesis is shown to involve the neurodegeneration-related RNA-binding proteins TDP-43 and FUS.', 'Similar alterations in miR-183/96/182, PP1, and R-SMADs are observed in the brains of patients with amyotrophic lateral sclerosis (ALS) or frontotemporal lobar degeneration (FTLD), two neurodegenerative diseases with pathological aggregation of TDP-43.'], ['In this era of aging societies, the number of elderly individuals who undergo spinal arthrodesis for various degenerative diseases is increasing.', 'Our aim in this review is to appraise the current state of knowledge and evidence regarding bone enhancement strategies for spinal fusion for degenerative spinal disorders, and to identify future directions for biological bone enhancement strategies, including pharmacological, cell and gene therapy approaches.'], ["Tau protein accumulation is the most common pathology among degenerative brain diseases, including Alzheimer's disease (AD), progressive supranuclear palsy (PSP), traumatic brain injury (TBI), and over twenty others.", 'Collectively, these findings indicate a strong association between the presence of NFTs and cellular senescence in the brain, which contributes to neurodegeneration.', 'Given the prevalence of tau protein deposition among neurodegenerative diseases, these findings have broad implications for understanding, and potentially treating, dozens of brain diseases.'], ['BACKGROUND: Multimorbidity (defined as >=2 chronic conditions) has been associated with increased risk of mild cognitive impairment and cross-sectionally with imaging biomarkers of neurodegeneration in cognitively unimpaired persons aged >=70 years.', 'CONCLUSIONS: Multimorbidity was associated with biomarker combinations that included neurodegeneration with or without elevated amyloid deposition (ie, A-N+, A+N+).'], ["In this review, we examine the therapeutic potential of the ECS for the treatment of chronic neurodegenerative diseases of the CNS focusing on Alzheimer's disease, Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis.", 'Third, we review the clinical evidence and discuss the future perspectives on how to bridge human and animal studies to develop cannabinoid-based therapies for each neurodegenerative disorder.', 'Finally, we summarize the most relevant opportunities of cannabinoid pharmacology related to each disease and the multiple unexplored pathways in cannabinoid pharmacology that could be useful for the treatment of neurodegenerative diseases.'], ['Symptoms of AD worsen over time due to progressive neurodegeneration, requiring institutional care at the later stage and resulting in a heavy burden on patients, caregivers, and the public-health system.'], ["Alzheimer's disease (AD) is an enervating and chronic progressive neurodegenerative disorder, occurring frequently in the elderly and adversely affecting intellectual capabilities and the cognitive processes."], ['Whilst multiple studies indicate that omega fatty acids can protect against neurodegeneration in older adults, more work is needed in the years preceding the diagnosis of such medical conditions.'], ['Two commonly used semisynthetic second-generation tetracycline derivatives, minocycline and doxycycline, exhibit effective neuroprotective activity in experimental models of neurodegenerative/ neuropsychiatric diseases and no substantial toxicity.'], ['These studies, however, need to be conducted taking into consideration brain region specificity and stage of neurodegeneration in order to provide insights about the pathological role of the identified proteins.', 'RESULTS: Ezrin was identified as a protein that is upregulated in tau-mediated neurodegeneration.', 'CONCLUSION: The results demonstrate that increased Ezrin protein abundance changes are associated with the early stages of neurodegeneration in tauopathy models and human disease.', 'Understanding the role of Ezrin in tauopathies such as AD may provide new insights for targeting tau-mediated neurodegeneration.'], ["Thus, defective P2X7-mediated phagocytosis may contribute to age-related neuro-degenerative diseases including Alzheimer's disease, age-related macular degeneration and primary progressive multiple sclerosis."], ["TDP-43 proteinopathy contributes to the detrimental effect of APOE epsilon4 on late-life cognition through mechanisms independent of Alzheimer's disease pathology, and future research should consider that TDP-43 proteinopathy might be an integral component of APOE-related neurodegeneration."], ['RESULTS: We demonstrated that administration of anti-TLR2 alleviated alpha-synuclein accumulation in neuronal and astroglial cells, neuroinflammation, neurodegeneration, and behavioral deficits in an alpha-synuclein tg mouse model of PD/DLB.'], ['OBJECTIVE: Homeostasis is one of the key concepts of physiology and the basis to understand chronic-degenerative disease and human ageing, but is difficult to quantify in clinical practice.'], ['Metabolic genetic blocks in processing and catabolism of SGC result in development of severe storage disorders, dominated by CNS involvement including marked neuroinflammation and neurodegeneration, the pathophysiological mechanisms of which are still discussed.'], ['The term oligodendrogliopathy highlights the prominent role of altered oligodendrocytes in the pathogenesis of certain neurological diseases, not only in demyelinating diseases and most leukodystrophies, but also in aging and age-related neurodegenerative diseases with abnormal protein aggregates.', "The present review focuses first on general aspects of oligodendrocytes and precursors, and their development and functions, and then introduces and updates alterations and dysfunction of oligodendrocytes in selected neurodegenerative diseases with abnormal protein aggregates such as multiple system atrophy, Lewy body diseases, tauopathies, Alzheimer's disease, amyotrophic lateral sclerosis, frontotemporal lobar degeneration with TDP-43 inclusions (TDP-43 proteinopathies), and Creutzfeldt-Jakob s disease as a prototypical human prionopathy."], ['Selection of regions was based on their different vulnerability to prevalent neurodegenerative diseases in aging.', 'However, no clear relationship can be established between NKT, MDA, COX-2 and CYP2J2 levels, and regional vulnerability to neurodegeneration in old age.'], ['Several regulatory factors that contribute to energy homeostasis have been implicated in the development and progression of many pathological conditions, such as neurodegenerative, metabolic, and cardiovascular disorders, among others.'], ['Neurodegenerative diseases are complex, progressive disorders and affect millions of people worldwide, contributing significantly to the global burden of disease.', "In this chapter, we describe the current state of play for epigenetic research into neurodegenerative disorders including Alzheimer's disease, Parkinson's disease and Huntington's disease.", 'Finally, we discuss how new technological and bioinformatics advances in the field of epigenetics could further progress our understanding about the underlying mechanisms of neurodegenerative diseases.'], ['The growing association between neurodegeneration and inflammation has led researchers to investigate interactions of sirtuins with inflammatory markers in neurodegenerative diseases.'], ['Sphingolipids are bioactive molecules associated with oxidative stress, inflammation, and neurodegenerative diseases, but poorly studied in the context of age-related macular degeneration (AMD), a prevalent sight-threatening disease of the ageing retina.'], ['Relieving toxicity and maintenance of genomic integrity are of clinical importance in relation to erythema/edema and diseases such as cancer, neurodegeneration and premature ageing, respectively.'], ['Eotaxin is increased in neurodegenerative disorders and schizophrenia, and preclinical studies indicate that eotaxin may induce cognitive deficits.'], ['Given the heterogeneous nature of frontotemporal dementia (FTD), sensitive biomarkers are greatly needed for the accurate diagnosis of this neurodegenerative disorder.', 'Circulating miRNAs have been reported as promising biomarkers for neurodegenerative disorders and processes affecting the central nervous system, especially in aging.'], ['11% had PD plus cerebrovascular lesions, 6 cases (6.7%) were cerebrovascular disorders and 8 cases (8.9%) were other neurodegenerative diseases (AD, single cases of multiple system atrophy, progressive supranuclear palsy).'], ['The single greatest risk factor for neurodegenerative diseases is aging.', 'Our results also further develop the potential utility of an in vitro model of senescent microglia for the study of brain aging and neurodegenerative disease.'], ['In this respect, technical developments with ultrasensitive immunoassays and novel mass spectrometry techniques give promise of biomarkers to monitor brain amyloidosis (the Abeta42/40 or APP669-711/Abeta42 ratios) and neurodegeneration (tau and neurofilament light proteins) in plasma samples, but future studies are warranted to validate these promising results further.'], ['Aging is an unequivocal risk factor for chronic neurodegenerative diseases, underscoring the relevance of investigations into the role that DNA alterations may have in the pathogenesis of these diseases.', 'Addressing these issues would shed light on age-related mechanisms impinging upon PD pathogenesis and neurodegeneration in particular.'], ['The progressive loss of structure and function of neurons causes various neurodegenerative diseases which need to be examined using measurable indicators, known as biomarkers.', 'When biologically essential proteins are impaired, it leads to devastating consequences in humans and mammals among which the most prominent is neurodegenerative disease.', 'The genetic and molecular origins of protein misfolding in association with their relationship with neurodegeneration and aging are being studied to better understand and develop treatments.', 'Accumulations of these misfolded proteins form aggregates which is considered as the most prominent cause of many neurodegenerative diseases.', 'This article reviews the misfolded proteins in various neurodegenerative diseases and analyzes the diverse aspects of protein misfolding as a potential agent of biomarkers with an approach for finding an inhibitor for misfolding.'], ["BACKGROUND: The role of the innate immune system in Alzheimer's disease (AD) and neurodegenerative disease susceptibility has recently been highlighted in genetic studies."], ['A comprehensive literature review of iron status in the elderly was undertaken in order to update a previous review (Fairweather-Tait et al, 2014); 138 summarised papers describe research on the magnitude of the problem, aetiology and age-related physiological changes that may affect iron status, novel strategies for assessing iron status with concurrent health conditions, hepcidin, lifestyle factors, iron supplements, iron status and health outcomes (bone mineral density, frailty, inflammatory bowel disease, kidney failure, cancer, cardiovascular, and neurodegenerative diseases).'], ["Alzheimer's disease (AD) is a heterogeneous neurodegenerative disorder and represents the most common form of dementia in the elderly.", 'Seizures have traditionally been related to neuronal loss in the late stages of AD as a consequence of neurodegeneration, however, recent studies indicated that seizures may contribute to the emergence of AD symptoms in early stages of the disease, mainly in familial AD.'], ['While current research on AD has focused on amyloid-betapeptide deposition, tau-pathology, and microglial activation and inflammation, greater attention to the cerebrovascular contribution to this neurodegenerative disease presents an additional target for therapeutic prevention and intervention.'], ['We excluded individuals currently receiving treatment for their dizziness, those with degenerative neurological conditions including cognitive impairment, those unable to walk 20 meters, and those identified at baseline assessment with conditions that required urgent treatment.'], ['However, ALDH2 dysfunction is also involved in a wide range of human pathophysiological situations and is associated with complications such as cardiovascular diseases, diabetes mellitus, neurodegenerative diseases and aging.'], ['This group of rare diseases represents a key model for tackling the pathogenic mechanisms involving mitochondrial biology relevant to much more common disorders that affect our currently ageing population, such as diabetes and metabolic syndrome, neurodegenerative and inflammatory disorders, and cancer.'], ['In addition, several studies have shown that DHEA and DHEAS are neuroprotective under different experimental conditions, including models of ischemia, traumatic brain injury, spinal cord injury, glutamate excitotoxicity, and neurodegenerative diseases.'], ['DHEA/DHEAS possess pleiotropic effects in human aging, bone, metabolic diseases, neurologic function/neurodegenerative diseases, cancer, immune system and disorders, cardiovascular diseases, diabetes, muscle function, sexual dysfunction, and other health conditions.'], ["As a long-term degenerative disorder of the central nervous system that mostly affects older people, Parkinson's disease is a growing health threat to our ever-aging population.", "Drug repurposing, also known as drug repositioning, or the process of finding new uses for existing or abandoned pharmaceuticals, has been recognized as a cost-effective and timeefficient way to develop new drugs, being equally promising as de novo drug discovery in the field of neurodegeneration and, more specifically for Parkinson's disease."], ['Morphological abnormalities of the bounding membranes of the nucleus have long been associated with human diseases from cancer to premature aging to neurodegeneration.'], ['Mitochondrial dysfunction and defective autophagy have been suggested to play important roles in normal aging as well as many neurodegenerative diseases.'], ['Osteoarthritis (OA) is a degenerative chronic disease affecting >300,000 million people around the world as of 2016.'], ["In the Predementia Neuroimaging of Transient Ischemic Attack (PREVENT) study, we will address what disease processes (i.e., Alzheimer's vs. vascular disease) lead to neurodegeneration, brain atrophy, and cognitive decline, and whether imaging measurements of brain iron accumulation using quantitative susceptibility mapping predicts subsequent brain atrophy and cognitive decline.", "Early Alzheimer's pathology will be determined by cerebrospinal fluid samples (including tau, a marker of neuronal injury, and amyloid beta1-42) and by MR measurements of iron accumulation, a marker for Alzheimer's-related neurodegeneration."], ['BACKGROUND: Dual-task paradigms, in which an individual performs tasks separately and then concurrently, often demonstrate that people with neurodegenerative disorders experience more dual-task interference, defined as worse performance in the dual-task condition compared to the single-task condition.'], ["Alzheimer's disease (AD) is an irreversible neurodegenerative disorder with the clinical symptom of the progressive loss of cognitive function and mild cognitive impairment (MCI) is a translational state between cognitive changes of normal aging and AD."], ['Results indicate that time gaps between sessions should be kept constant and that head motion must be taken into account when using RSN to assess aging and neurodegeneration.'], ['BACKGROUND: Alzheimer disease (AD) is a common neurodegenerative disorder with distinct pathological features, with aging considered the greatest risk factor.'], ['The most marked neurodegeneration in patients with DA deficiency is observed in the nigro-striatal DA neurons, which contain abundant TH.', 'However, this decrease in TH is thought to be secondary due to neurodegeneration of DA neurons caused by some as yet unidentified genetic and environmental factors, and thus, TH deficiency may not play a direct role in PD.'], ['The aging of the world population is accompanied by a substantial increase in neurodegenerative disorders, such as dementia.'], ["Tau pathology is one of the most common proteinopathies that associates with age-dependent neurodegenerative diseases including Alzheimer's disease (AD), and various Parkinsonism."], ['However, clinical geriatrics and gerontology research has included cognition and depression in models of physical disability, with less attention to the pathophysiology of neurodegenerative disease.', 'Similarly, AD research generally incorporates limited, if any, measures of physical function and mobility, and therefore often fails to consider the relevance of functional limitations in neurodegeneration.'], ['Misfolding and accumulation of cellular protein aggregates are pathological hallmarks of aging and neurodegeneration.', 'Nutritional interventions abundant in pharmacologically potent polyphenols have demonstrated a therapeutic role for combating protein aggregation associated with neurodegeneration.'], ["INTRODUCTION: elderly's malnutrition is linked, among other factors, to chronic-degenerative diseases, requiring an improvement in the clinical evaluation of nutritional status of this population."], ['BACKGROUND: In neurodegenerative disorders or in normal aging humans a relationship between muscle mass and/or performance and brain volume was observed, that is not dependent on age or other confounding factors.'], ['Brain "inflammaging," a low-grade and chronic inflammation, is a major hallmark for aging-related neurodegenerative diseases.'], ["Neurodegenerative disorders such as Parkinson's disease (PD) and dementia with Lewy bodies (DLB) are characterized by impairment of autophagy."], ['A unique member of the known Sirtuin family, SIRT6 has several different functions in multiple different molecular pathways related to DNA repair, glycolysis, gluconeogenesis, tumorigenesis, neurodegeneration, cardiac hypertrophic responses, and more.', 'Even until very recently, SIRT6 was known more for chromatin signaling but, being a nascent topic of study, more information has been ascertained and its potential involvement in major human diseases including diabetes, cancer, neurodegenerative diseases, and heart disease.', 'In this review, we are primarily concerned with exploring the latest advances in understanding SIRT6 and how it can alter the course of several life-threatening diseases such as processes related to aging, cancer, neurodegenerative diseases, heart disease, and diabetes (SIRT6 has also shown to be involved in liver disease, inflammation, and bone-related issues) and any recent promising pharmacological investigations or potential therapeutics that are of interest.'], ['The right temporal lobe variant of frontotemporal dementia (FTD) is an uncommon progressive neurodegenerative disorder.'], ['Alterations in proteins that function in DNA replication and repair have been implicated in the development of human diseases including cancer, premature ageing, skeletal disorders, mental retardation, microcephaly, and neurodegeneration.'], ['Diffusion-weighted imaging (DWI) is sensitive, if not specific, to early disease-related white matter (WM) change in a variety of traumatic and degenerative brain diseases.'], ['Consequently, these participants attributed all joint complaints or even all physical complaints to RA, disregarding degenerative joint disease and physiological aging as alternative diagnoses.'], ['Neuropathologic evaluation remains the gold standard for determining the presence and severity of aging-related neurodegenerative diseases.'], ['Cockayne Syndrome (CS) is a rare autosomal recessive disorder, which leads to neurodegeneration, growth failure and premature aging.'], ['Oxidative stress is related to ageing and degenerative diseases, including cancer.'], ['BACKGROUND: Oxidative stress (OS) plays a substantial role in inflammatory and neurodegenerative diseases, causing cellular damage and mitochondrial dysfunction.'], ['RESULTS: Using the combination of amyloid (A), tau (T), and neurodegeneration (N) biomarkers, the Framework provides a means of defining the state of patients with regard to Alzheimer pathologic change.'], ['These 3R or 4RTau species are differentially expressed in neurodegenerative diseases.'], ["Regular cognitive follow-up of patients who had cognitive impairment before cancer treatment should monitor symptoms suggestive of neurodegenerative disease and avert the effect of cognitive disorders on patients' autonomy."], ['The cellular and biochemical events that contribute to neurodegeneration and premature aging in CHIP KO models remain poorly understood.'], ['Traumatic brain injury (TBI) is a risk factor for development of chronic neurodegenerative disorders later in life.', "This review summarizes the current knowledge and concepts regarding the connection between long-term consequences of TBI and aging-associated neurodegenerative disorders including Alzheimer's disease (AD), chronic traumatic encephalopathy (CTE), and Parkinsonism, with implications for novel therapy targets.", 'Several aggregation-prone proteins such as the amyloid-beta (Abeta) peptides, tau proteins, and alpha-synuclein protein are involved in secondary pathogenic cascades initiated by a TBI and are also major building blocks of the hallmark pathological lesions in chronic human neurodegenerative diseases with dementia.', 'Impaired metabolism and degradation pathways of aggregation-prone proteins are discussed as potentially critical links between the long-term aftermath of TBI and chronic neurodegeneration.', 'Utility and limitations of previous and current preclinical TBI models designed to study the link between TBI and chronic neurodegeneration, and promising intervention pharmacotherapies and non-pharmacologic strategies to break this link, are also summarized.'], ['Background: Osteoarthritis (OA) is one of the most common degenerative disorders among the elderly population; although aging is the most important cause, research has shown that it is a complex disease with many etiologies.'], ["Understanding short-term cognitive decline in relation to Alzheimer's neuroimaging biomarkers in early stages of the development of neuropathology and neurodegeneration will inform participant recruitment and monitoring strategies in clinical trials aimed at prevention of cognitive impairment and dementia.", 'We categorized each individual based on dichotomous amyloid pathology (A) and hippocampal neurodegeneration (N) status at baseline: A-N-, A+N-, A-N+, A+N+.', 'We conducted linear mixed effects analyses to assess cross-sectional and longitudinal trends in cognitive test z-scores by amyloid and neurodegeneration group.', 'Our results suggest that both amyloid pathology and neurodegeneration have disadvantageous, in part synergistic, effects on prospective cognition.'], ['OBJECTIVE: To investigate the cognitive profile of healthy individuals with increased Cardiovascular Risk Factors, Aging and Dementia (CAIDE) dementia risk score and to explore whether this association is related to vascular burden and CSF biomarkers of amyloidosis and neurodegeneration.'], ['As our brains age, we tend to experience cognitive decline and are at greater risk of neurodegenerative disease and dementia.'], ['We review recent research exploring the protective effects of flavonoids on age-related cognitive decline and neurodegenerative disorders in humans and animals.', 'RECENT FINDINGS: Flavonoids have been found to decrease neuroinflammation, reduce oxidative stress, and mediate neuroplasticity in animal models of neurodegeneration and aging.', 'Flavonoid supplementation, as well as dietary modification to include whole foods high in flavonoids, may provide therapeutic potential for aging individuals experiencing cognitive deficits resulting from neurodegeneration.'], ['Prion diseases are a unique group of chronic neurodegenerative diseases that affect humans and certain domestic and free-ranging animal species.', "Although the pathology during prion disease appears to be restricted to the central nervous system, where it causes extensive neurodegeneration, some prion diseases accumulate to high levels within the secondary lymphoid tissues of the host's immune system as they make their journey from the site of infection to the brain."], ["CONTEXT: Parkinson's disease (PD) is the second common progressive neurodegenerative disease, distressing older men and is prevalent Worldwide."], ['We found the presence of amyloid beta plaques, tau tangles, neurodegeneration, and astrogliosis in the retinal ganglion cell layer of 3xTg-AD mice, already at pre-symptomatic stage.', 'We hypothesize retina as a window through which monitor AD-related neurodegeneration process.'], ['Autophagy, a lysosomal degradation pathway, plays a crucial role in cellular homeostasis, development, immunity, tumor suppression, metabolism, prevention of neurodegeneration, and lifespan extension.'], ['Given the benefits of physical activity for the prevention of neurodegenerative disease and the improvement of the well-being, it appears to be an important low cost therapeutic approach that should be integrated into clinical practice.'], ['Aging and neurodegenerative disease are characterized by genomic instability in neurons, including aberrant activation and mobilization of transposable elements (TEs).'], ["Parkinson's disease (PD) is the second most common age-related neurodegenerative disease in the elderly and the patients suffer from uncontrolled movement disorders due to loss of dopaminergic (DA) neurons on substantia nigra pars compacta (SNpc)."], ["Alzheimer's disease (AD) is a chronic neurodegenerative disease of the elderly that seriously affects the quality of life and the life expectancy of those affected."], ['Human umbilical cord blood cells (HUCBC) have proven useful as potential immunomodulatory therapies in various models of neurodegenerative diseases, including AD.'], ['Evidence from animal-model and human observational studies suggest that childhood lead exposure may raise the risk of adult neurodegenerative disease, particularly dementia, through a variety of possible mechanisms including epigenetic modification, delayed cardiovascular and kidney disease, direct degenerative CNS injury from lead remobilized from bone, and lowered neural and cognitive reserve.', 'Should childhood lead exposure prove pro-degenerative, the next twenty years will provide the last opportunities for possible early intervention to forestall greater degenerative disease burden across the aging lead-exposed population.'], ['OBJECTIVES: To summarize progress over the past five years and its implications for understanding neurodegenerative diseases.'], ['Second, a risk factor may have quantifiably greater impact as a trigger and/or accelerator on a specific component of the biomarker cascade (amyloid, tau, neurodegeneration).'], ['This article attempts to provide such information for the most common degenerative diseases of the spine and musculoskeletal system.'], ['Epigenetic mechanisms play an important role in the development and progression of various neurodegenerative diseases.', 'Further research is necessary to define a detailed role of TRIM59 and KLF4 in neurodegeneration of neurons.'], ['Cardiovascular, cerebrovascular, and neurodegenerative diseases are particularly prevalent in the elderly population.'], ['Neurodegeneration and many other diseases linked to RNA granules are associated with aging.'], ['Within the novel genetic loci are variants associated with neurodegenerative and neurodevelopmental disorders, physical and psychiatric illnesses, and brain structure.'], ["Wnt pathway is involved in synaptic plasticity and neuronal survival, and alterations in Wnt signaling have previously been reported both in aging and neurodegenerative diseases, including Alzheimer's disease (AD)."], ['The mammalian and yeast antioxidant responses are similar and over 25 % of human-degenerative disease related genes have close homologues in yeast.'], ['Together, the sex difference in the association between APOE and CSF measures of tau and the lack of a sex difference in the association with neurofibrillary tangles at autopsy suggest that APOE may modulate risk for neurodegeneration in a sex-specific manner, particularly in the presence of amyloidosis.'], ['Brain aging and associated neurodegeneration constitute a major societal challenge as well as one for the neuroimaging community.', 'A full understanding of the physiological mechanisms underlying neurodegeneration still eludes medical researchers, fuelling the development of in vivo neuroimaging markers.', 'Given the rapid technical advances in fMRI in recent years, this review aims to summarize the physiological basis of fMRI observations in healthy aging as well as in age-related neurodegeneration.'], ['Tea consumption is considered a natural complementary therapy for neurodegenerative diseases.'], ['Changes to these parameters across the lifespan may precede neurodegeneration and contribute to age-related cognitive decline.'], ["BACKGROUND: Disease-associated-microglia (DAM) represent transcriptionally-distinct and neurodegeneration-specific microglial profiles with unclear significance in Alzheimer's disease (AD).", 'METHODS: Weighted co-expression network analysis (WGCNA) was applied to existing microglial transcriptomic datasets from neuroinflammatory and neurodegenerative disease mouse models to identify modules of highly co-expressed genes.', 'These guided in-vivo and in-vitro studies in mouse models of neuroinflammation and neurodegeneration (5xFAD) to determine whether inhibition of pro-inflammatory gene expression and promotion of amyloid clearance was feasible.', 'CONCLUSIONS: We provide a predictive transcriptomic framework of microglial activation in neurodegeneration that can guide pre-clinical studies to characterize and therapeutically modulate neuroinflammation in AD.'], ['The ability to read irregularly spelled words is commonly used to estimate premorbid intelligence, as this ability has been thought to be resistant to early effects of neurodegenerative disorders.'], ['Thus, mitophagy as a potential therapeutic target in AMD and other degenerative diseases is as well explored.'], ['BACKGROUND: Prior studies in C. elegans demonstrated that the expression of aggregation-prone polyglutamine proteins in muscle wall cells compromised the folding of co-expressed temperature-sensitive proteins, prompting interest in whether the accumulation of a misfolded protein in pathologic features of human neurodegenerative disease burdens cellular proteostatic machinery in a manner that impairs the folding of other cellular proteins.'], ["A major challenge in the field of neurodegenerative diseases and brain aging is to identify the body's intrinsic mechanism that could sense the central nervous system (CNS) damage early and protect the brain from neurodegeneration.", 'Accumulating evidence suggests that disease-associated microglia (DAM), a recently identified subset of CNS resident macrophages found at sites of neurodegeneration, might play such a protective role.', 'Here, we propose that microglia are endowed with a dedicated sensory mechanism, which includes the Trem2 signaling pathway, to detect damage within the CNS in the form of neurodegeneration-associated molecular patterns (NAMPs).'], ['Increasing evidence has shown that nucleophagy may play a major role in such human diseases as degenerative disorders, tumorigenesis, malnutrition and metabolic disorders, parakeratosis and psoriasis.', 'Studies indicated that nucleophagy can improve degenerative disorders by delaying premature cell senescence, prevent malnutrition and metabolic disorder via maintaining nuclear structure and releasing nutrients for energy production, and alleviate parakeratosis and psoriasis.'], ["Alzheimer's disease (AD) is a progressive irreversible neurodegenerative disorder characterized by excessive deposition of beta-amyloid (Abeta) oligomers, and neurofibrillary tangles (NFTs), comprising of hyperphosphorylated tau proteins."], ['In addition, based on our in vitro approach, our data suggest that aging may be an important modifier of SG dynamics which could have relevance to the initiation and/or progression of age-related neurodegenerative diseases.'], ['Lysosomal accumulation of undegraded materials is a common feature of lysosomal storage diseases, neurodegenerative disorders, and the aging process.'], ['Retarded growth and neurodegeneration are hallmarks of the premature aging disease Cockayne syndrome (CS).'], ["Some evidence suggests that in the setting of neurodegenerative diseases that manifest with abnormal protein deposition in the brain, such as Alzheimer's disease, reducing IGF1 signaling may serve a protective role by slowing disease progression and augmenting clearance of pathologic proteins to maintain cellular homeostasis."], ['At the same time, oxidative stress is involved in several age-related conditions (ie, cardiovascular diseases [CVDs], chronic obstructive pulmonary disease, chronic kidney disease, neurodegenerative diseases, and cancer), including sarcopenia and frailty.'], ['In the discovery stage, genome-wide logistic and linear regression analyses were done to test the association of genetic variants with disease risk (case or control status) and age at onset in patients with a GRN mutation and controls free of neurodegenerative disorders.', 'After quality control measures, statistical analyses in the discovery stage included 382 unrelated symptomatic GRN mutation carriers and 1146 controls free of neurodegenerative disorders collected from 34 research centres located in the USA, Canada, Australia, and Europe.', 'In the replication stage, 210 patients (67 symptomatic GRN mutation carriers and 143 patients with FTLD without GRN mutations pathologically confirmed as FTLD-TDP type A) and 1798 controls free of neurodegenerative diseases were recruited from 26 sites, 20 of which overlapped with the discovery stage.'], ['Further studies are required to clarify this disease in the context of old age, comorbidity, and possible concomitant neurodegenerative diseases.'], ["Regional myocardial motion indices have the potential to become novel quantitative imaging biomarkers for representing the risk of neurodegenerative disorders, such as Alzheimer's disease (AD)."], ['Although AD is most commonly regarded as a disease of the memory, the entire brain is eventually affected by neuronal dysfunction or neurodegeneration, which brings about a host of other behavioral disturbances.'], ['Ageing, a leading cause of the decline/deficits in human learning, memory, and cognitive abilities, is a major risk factor for age-associated neurodegenerative disorders such as Alzheimer’s disease.', 'Therefore, the impact of DNMTs and DNA methylation on age-associated cognitive functions and neurodegenerative diseases has emerged as a pivotal topic in the field.'], ['INTRODUCTION: Malignant ischemic stroke of the middle cerebral artery (MCA) territory causes neurological deterioration due to the effects of space occupying cerebral edema.'], ['Frailty has been demonstrated to be a predictor of morbidity and mortality in inpatient head and neck surgery, and for surgical intervention for adult spinal deformity and degenerative spine disease.'], ['To better understand the mechanistic underpinnings of WMHs among older adults, this study examined in vivo cerebrospinal fluid biomarkers of beta-amyloid42 deposition (Abeta42), hyperphosphorylated tau pathology, neurodegeneration (total tau), and axonal injury (neurofilament light [NFL]) in relation to log-transformed WMHs volume.'], ['This study is the first to provide a fine-grained and comprehensive taxonomy to parse external details into intuitive subcategories and to validate this protocol in neurodegenerative disorders.'], ["BACKGROUND: Alzheimer's disease (AD) is a devastating neurodegenerative disorder bearing multiple pathological hallmarks suggestive of complex cellular/molecular interplay during pathogenesis."], ["Age-related dementias are now a major mortality factor among most human populations in the world, with Alzheimer's disease (AD) being the leading dementia-causing neurodegenerative disease."], ['Dementia is the most widespread form of neurodegenerative disorder and is associated with an immense societal and personal cost.'], ['The aging of brain in the absence of neurodegenerative diseases, usually called non-pathological brain aging or normal cognitive aging, is characterized by an impairment of memory and cognitive functions.'], ['Conclusions The brain health index is a new image analysis approach that may usefully capture combined visible brain damage in large-scale studies of ageing, neurovascular and neurodegenerative disease.'], ["The scenario is further complicated with the two most prevalent age-related neurodegenerative diseases, Alzheimer's disease (AD) and Parkinson's disease (PD)."], ["Alzheimer's disease (AD) is the most common neurodegenerative disorders in the elderly."], ['In particular, current studies reveal that the peripheral deafferentations of stomatognathic systems may be projected globally into the central nervous system (CNS) and become an associated critical factor in triggering and aggravating neurodegenerative diseases.', 'A growing understanding of the association between DD and brain aging may lead to solutions in treating and preventing cognitive decline and neurodegenerative diseases.'], ['OBJECTIVE: To examine in a 3-year brain imaging study the effects of higher vs lower adherence to a Mediterranean-style diet (MeDi) on Alzheimer disease (AD) biomarker changes (brain beta-amyloid load via 11C-Pittsburgh compound B [PiB] PET and neurodegeneration via 18F-fluorodeoxyglucose [FDG] PET and structural MRI) in midlife.'], ['Biomarkers are grouped into those of beta amyloid deposition, pathologic tau, and neurodegeneration [AT(N)].', 'Although it is possible that beta-amyloid plaques and neurofibrillary tau deposits are not causal in AD pathogenesis, it is these abnormal protein deposits that define AD as a unique neurodegenerative disease among different disorders that can lead to dementia.'], ['We report that a neuroprotective cyclic heptapeptide, CHEC-7, which has been applied systemically as a therapeutic in animal neurodegeneration models, disrupts such aggregates and inhibits amyloidogenesis when added in nanomolar concentrations to human plasma.'], ['The importance of these structures is now unquestioned given the wide range of degenerative diseases that stem from LMNA gene mutations, including muscular dystrophy disorders, peripheral neuropathies, lipodystrophies, and premature aging syndromes.'], ['Therefore, promotion of intracellular NAD+ anabolism represents a promising therapeutic strategy for age-associated degenerative diseases in general, and is essential to the effective realization of multiple benefits of healthy sirtuin activity.', 'Recent Advances: In this review, we describe and discuss recent insights regarding the efficacy and benefits of the NAD+ precursors, nicotinamide (NAM), nicotinic acid (NA), nicotinamide riboside (NR), and nicotinamide mononucleotide (NMN), in attenuating NAD+ decline in degenerative disease states and physiological aging.'], ["Alzheimer's disease (AD) is the most common cause of neurodegenerative disorder in elderly people, and has become a social problem in aging societies globally."], ['During aging we detected a dramatic neurodegeneration including neuron loss and pathological neurofilament abnormalities only in TDP43 mutant cultures.'], ['Impairment of the main noradrenergic nucleus of the human brain, the locus coeruleus (LC), which has been discovered in 1784, represents one of defining factors of neurodegenerative diseases progression.', 'There is a direct correlation between the reduction in noradrenergic innervations and cognitive decline associated with ageing and neurodegenerative diseases.'], ['Moreover, recent evidence suggests that senescence-induced perturbations of the gut-brain axis are involved in the neuroinflammation process, thus raising the hypothesis that preserving gut permeability and preventing frailty-related changes in the microbiota composition might reduce the susceptibility to develop neurodegenerative disorders.'], ['The contribution of these mutations to aging and progress of neurodegenerative diseases is actively studied.'], ['These findings may offer new insights into the implications of TERT in the treatment of stress-induced conditions such as aging, obesity, and neurodegenerative diseases.'], ['DISCUSSION: An impaired sense of smell may serve as a readily accessible early marker of neurodegeneration and improve upon the prevailing delayed diagnoses and underascertainment of MCI/dementia.'], ['Oxidative stress caused by inflammation, intrinsic cell factors or environmental exposures, contributes to the pathogenesis of many degenerative diseases and cancer.'], ['Dementia with Lewy bodies (DLB) is a common neurodegenerative dementia in older people; however, the clinical features, particularly cognitive fluctuations and rapid eye movement sleep disorder, are often hard to elicit, leading to difficulty in making the diagnosis clinically.'], ['Age-related macular degeneration (AMD) is a devastating neurodegenerative disease affecting millions worldwide.'], ['However, a more complete picture reveals significant neurodegeneration and decreased cell survival, neuroinflammation, changes in protein and energy homeostasis and alterations in lipid and cholesterol metabolism.', 'In addition, gene and cell therapies for severe neurodegenerative disorders have recently improved technically in terms of safety and efficiency and have translated to the clinic showing encouraging results.'], ['There is growing evidence that A-T patients suffer from pathologic inflammation that is responsible for many symptoms of this syndrome, including neurodegeneration, autoimmunity, cardiovascular disease, accelerated aging, and insulin resistance.'], ["Amyloids are clearly linked to the pathogenesis of age-related degenerative diseases such as Alzheimer's disease."], ['The enrichment of senescent cells in tissues with age has been associated with tissue dyshomeostasis and age-related pathologies including cancers, neurodegenerative disorders (e.g.', 'Such a connection between cellular autophagy and copper homeostasis is significant, as both have emerged as important facets of age-associated degenerative disease.'], ['BACKGROUND: Cortical gray matter (GM) and white matter (WM) deterioration are signals of neurodegeneration and increased dementia risk; however, their specific etiologies in dementia-free aging is unclear.'], ['The human Sirtuin isoforms, SIRT1-7, are considered attractive therapeutic targets for aging-related diseases, such as type 2 diabetes, inflammatory diseases and neurodegenerative disorders.'], ['Here, we analyzed aged iTDP-43A315T mice, focusing on the spatiotemporal profile and progression of neurodegeneration in upper and lower motor neurons.'], ['Characteristics include progressive neurologic deterioration with extrapyramidal involvement and polyendocrinopathy most notable for hypogonadism starting in early adolescence.'], ["Dysregulation of endolysosomal pH has been linked to aging, amyloidogenesis, synaptic dysfunction, and various neurodegenerative disorders, including Alzheimer's disease."], ['These findings indicate that Rab10 phosphorylation could be responsible for aberrations in the vesicle trafficking observed in AD leading to neurodegeneration.'], ['Scientific proofs are accumulating in experimental models, but, to a minor extent, also in humans, that the ancient practice of calorie restriction could prove an effective way to prevent several degenerative diseases and to postpone the detrimental signs of ageing.'], ["Importantly, aging is also the primary risk factor for the development of neurodegenerative disorders such as Alzheimer's disease.", 'As such, there is an urgent need to provide a greater understanding of both the pathogenesis and treatment of these devastating neurodegenerative disorders.'], ['RESULTS: When using the core CSF biomarkers (Abeta42, total Tau and phosphorylated Tau), 30% of the patients fell into the high-AD-likelihood (HL) group (both amyloid and neurodegeneration markers positive), 30% into the low-AD-likelihood group (all biomarkers negative), 28% into the suspected non-Alzheimer pathophysiology (SNAP) group (only neurodegeneration markers positive) and 12% into the isolated amyloid pathology group (only amyloid-positive).'], ['BACKGROUND: With the global increase in lifespan expectancy, neurodegenerative disorders continue to affect an ever-increasing number of individuals throughout the world.', 'New treatment strategies for neurodegenerative diseases are desperately required given the lack of current treatment modalities.', 'METHODS: Here, we examine novel strategies for neurodegenerative disorders that include circadian clock genes, non-coding Ribonucleic Acids (RNAs), and the mammalian forkhead transcription factors of the O class (FoxOs).', 'RESULTS: Circadian clock genes, non-coding RNAs, and FoxOs offer exciting prospects to potentially limit or remove the significant disability and death associated with neurodegenerative disorders.', 'FoxOs provide exciting prospects to block neuronal apoptotic death and to activate pathways of autophagy to remove toxic accumulations in neurons that can lead to neurodegenerative disorders.', 'CONCLUSION: Continued work with circadian clock genes, non-coding RNAs, and FoxOs can offer new prospects and hope for the development of vital strategies for the treatment of neurodegenerative diseases.'], ['In human it is found in CISD1-3 proteins involved in diabetes, obesity, cancer, aging, cardiovascular disease and neurodegeneration.'], ['Outside the context of severe degenerative diseases that affect the elderly populations, normal visible signs of ageing, notably skin sagging and wrinkles, influence the social and individual perception of peoples.'], ['Results: The most frequent disease among the responders was arterial hypertension (77.58%), followed by degenerative joint disease (62.10%), and circulatory failure (43.23%).', "Lower functional performance was associated with circulatory failure, cerebral stroke, atherosclerosis, Alzheimer's disease, diabetes, Parkinson's disease, degenerative joint disease, and bronchial asthma.", "Conclusion: Circulatory failure, cerebral stroke, atherosclerosis, bronchial asthma, diabetes, degenerative joint disease, Parkinson's disease, and Alzheimer's disease negatively affect functional performance in elderly people."], ["How the 'reserve' hypothesis applies in neurodegenerative disorders such as Huntington's disease (HD) remains unknown.", "We postulate that unless the 'reserve' hypothesis is tested empirically, it is impossible to draw firm conclusions about how task-related neural activity is providing a neuroplastic change in HD and possibly other neurodegenerative disorders."], ['Further work is needed to elucidate whether EDS is a clinical marker of greater sleep instability, synaptic or network overload, or neurodegeneration of wakefulness-promoting centers.'], ['Neurodegeneration represents a global problem due to the progressive increase in the aging population all over the world.', 'In this regard, several risk factors associated with the development of neurodegeneration can be identified, and programs to educate people on the key role of prevention could significantly ameliorate the future picture of the aging population.', 'Here we describe the key role of the pre- and postnatal period of life during the first 1000 days of life, focusing on the importance of nutrition and a healthy lifestyle of mother and offspring for the prevention of neurodegeneration later in life.', 'mediate the genetic and epigenetic signature of offspring which may have long-term effects on the onset of neurodegeneration.'], ['Insights from the genetics and pathology of human neurodegenerative diseases furthermore emphasize the importance of efficient axonal transport of lysosomes and their precursors.'], ['However, they are often associated with pathologies, including neurodegeneration and cancer, and changes in their dynamics are implicated in ageing.'], ["Converging evidence from structural, metabolic and functional connectivity MRI suggests that neurodegenerative diseases, such as Alzheimer's disease, target specific neural networks.", "Here we elucidate the differential effects of ageing and Alzheimer's disease pathology through simultaneous analyses of two functional connectivity MRI datasets: (i) young participants harbouring highly-penetrant mutations leading to autosomal-dominant Alzheimer's disease from the Dominantly Inherited Alzheimer's Network (DIAN), an Alzheimer's disease cohort in which age-related comorbidities are minimal and likelihood of progression along an Alzheimer's disease trajectory is extremely high; and (ii) young and elderly participants from the Harvard Aging Brain Study, a cohort in which imaging biomarkers of amyloid burden and neurodegeneration can be used to disambiguate ageing alone from preclinical Alzheimer's disease."], ["Alzheimer's disease (AD) is a multifactorial progressive neurodegenerative disease."], ['The most common diseases were: circulatory diseases (59.10%), spinal pain syndromes (51.50%), degenerative joint diseases (50.30%), and rheumatic diseases (23.90%).', 'Severe or extreme disability was found in 8.46% of patients with circulatory disease, 9.32% of patients with spinal pain syndromes, 9.34% of patients with degenerative joint diseases, and 12.13% of patients with rheumatic diseases.'], ['An open question, however, is why LFC connectivity is beneficial and supports memory function in the face of neurodegeneration.'], ['Motivation: Oxidative stress and protein damage have been associated with over 200 human ailments including cancer, stroke, neuro-degenerative diseases and aging.'], ['Regarding the physiopathological mechanisms, specific multimodal neuroimaging techniques allowed us to highlight the relevance of diaschisis, the mismatch between neurodegeneration and local Abeta deposition and the regional variation in the mechanisms underlying structural or functional alterations.'], ['Progressive Supranuclear Palsy (PSP) is a rare neurodegenerative disease whose etiopathogenesis remains elusive.', 'We suggest that MSCs could be a novel model system for unravelling cellular processes implicated in this neurodegenerative disorder.'], ['Our aim was to study whether social cognition discriminates bvFTD from other neurodegenerative diseases and psychiatric disorders in patients presenting with late-onset frontal symptoms.', 'METHODS: In this longitudinal multicenter study, besides clinical rating scales for frontal symptoms, social cognition was determined by Ekman 60 Faces test and Faux Pas in addition to neuropsychological tests for other cognitive domains in patients with probable and definite bvFTD (N = 22), other neurodegenerative diseases (N = 24), and psychiatric disorders (N = 33).', 'RESULTS: Total scores from Ekman 60 Faces test were significantly lower in bvFTD than in other neurodegenerative diseases and psychiatric disorders.', 'Ekman 60 Faces test explained 91.2% of the variance of psychiatric disorders and other neurodegenerative diseases versus bvFTD (chi2 = 11.02, df = 1, p = 0.001) and was associated with all other cognitive domains.', 'CONCLUSION: In this clinical sample Ekman 60 Faces test distinguished bvFTD successfully from other neurodegenerative diseases and psychiatric disorders.'], ['Since CI defects are associated with aging and neurodegeneration, it is pertinent to understand its structure-function relationship.', 'Among non-oxidative PTMs, protein phosphorylation is the most intricate regulatory mechanism controlling CI structure and function during normal physiology, aging and neurodegeneration.', 'We surmise that protein phosphorylation, a transient and regulatory event could influence the structure-function relationship of CI thereby impinging on bioenergetics and ultimately contributing to aging and neurodegeneration.'], ['Approximately half of afflicted individuals report either no or relatively unremarkable trauma preceding their diagnosis, raising the possibility that cSDH is a manifestation of degenerative or inflammatory disease rather than trauma.'], ['Reduced density of the alpha4beta2 nicotinic acetylcholine receptor (alpha4beta2-nAChR) in the cortex and hippocampus of the human brain has been reported in aging and patients with neurodegenerative disease.'], ['Other points are also stressed as exemplified in the analysis of human neurodegenerative diseases which are manifested by disease-, region-, and stage-specific modifications commonly in the context of aging.'], ['It is noteworthy that these alterations, when found in excess, are diagnostic for various neurodegenerative diseases, such as Alzheimer disease, Pick disease, progressive supranuclear palsy, corticobasal degeneration, Parkinson disease, Lewy body dementia, and frontotemporal lobar degeneration.'], ['Due to mechanisms of injury and pre-existing degenerative spinal disease, cervical spine fractures are particularly prevalent in elderly patients.'], ['OBJECTIVE: HIV infection and aging are both associated with neurodegeneration.', 'However, whether the aging process alone or other factors associated with advanced age account for the progression of neurodegeneration in the aging HIV-positive (HIV+) population remains unclear.'], ["Alzheimer's disease (AD) is the most common neurodegenerative disease and of continuously rising prevalence."], ['Some CAs, which are abundant in the brain, were recently demonstrated to be activatable by drug-like compounds, affording the possibility to design agents that enhance cognition, with potential therapeutic applications in aging and neurodegenerative diseases as well as tissue engineering.'], ['Insulin-like growth factor 1 (IGF-1) has been associated with osteoporosis, cardiovascular disease, cancer, neurodegenerative diseases, and mortality in middle and older aged adults.'], ['Chronic coffee consumption also appears to protect against some neurodegenerative diseases, and is associated with improved asthma control, and lower risks for liver disease and cancer.'], ["This article is part of the Special Issue entitled 'Metabolic Impairment as Risk Factors for Neurodegenerative Disorders.'"], ['Epilepsy is a neurological condition associated with seizures, neurodegeneration, circuit reorganization, and other structural and functional abnormalities.'], ['The hippocampal formation has been implicated in a growing number of disorders, from neurodegenerative diseases to atypical cognitive ageing and depression.'], ['In our ageing population, neurodegenerative disorders carry an enormous personal, societal and economic burden.', 'Although neurodegenerative diseases are often thought of as clinicopathological entities, increasing evidence suggests a considerable overlap in the molecular underpinnings of their pathogenesis.', 'Here, we describe broadly these concepts and their relevance across neurodegenerative diseases.'], ['As MTL subregions are differentially affected by aging and neurodegenerative diseases, the question was raised whether aging may affect the 2 pathways differentially.'], ['Loss of Ca2+ homeostasis is a key precursor in neuronal dysfunction associated with brain aging and in the pathogenesis of neurodegenerative disorders.', "PMCA activity is also diminished in post-mortem human brain samples from Alzheimer's disease and Parkinson's disease patients and in cell models of these neurodegenerative disorders.", 'Loss of PMCA is likely to contribute to neuronal dysfunction observed in the aging brain and in the development of age-dependent neurodegenerative disorders.'], ["The ageing process involves a complex interplay among various deleterious activities that profoundly disrupt the body's ability to cope with damage, thus increasing susceptibility to pathophysiologies such as neurodegeneration, central obesity, osteoporosis, type 2 diabetes mellitus and atherosclerosis."], ['Although the importance of CoQ10 has been mainly attributed to its role as an agent for energy transduction in mitochondria, new functions for CoQ10 have been described in the recent past years, including anti-inflammatory effects, gene expression regulation and lipid bilayer membranes stabilization, which explain its involvement in aging and age-related diseases such as cardiovascular diseases, renal failure and neurodegenerative diseases.'], ['Combination of NIR-T/BSS and time-frequency analysis may open up new frontiers in the understanding and diagnosis of various neurodegenerative and ageing related diseases to improve diagnostic procedures and patient prognosis.'], ["Since yeast and human brain may share similar strategies in coping with diverse range of critical environmental stresses, the objective of this paper was to discuss the potential role of evolvability of APs in aging-associated neurodegenerative disorders, including Alzheimer's disease and Parkinson's disease.", 'We propose that evolvability might be a physiological function of APs during the reproductive stage and neurodegenerative diseases could be a by-product effect manifested later in aging.'], ["They contain a large variety of novel materials useful for designing and developing new medicines and therapies directed against many aging-associated degenerative disorders, including Alzheimer's disease, Parkinson's disease, stroke, diabetes, osteoporosis, and cancers."], ["The association between Alzheimer's pathology and aneuploidy in regions with limited neurodegeneration is supported by a growing body of in vitro and in vivo data on aneuploidy and beta-amyloid and tau abnormalities.", 'Large-scale studies using high-resolution techniques alongside other sensitive and specific methodologies are now required to assess the true extent of cell- and region-specific aneuploidy in aging and neurodegeneration, and to determine any associations with pathologies.'], ['Emerging evidence suggests that these organelles serve as guardians and modulators of cellular redox balance, and that alterations in their redox metabolism may contribute to aging and the development of chronic diseases such as neurodegeneration, diabetes, and cancer.'], ["In middle and old age, Alzheimer's disease (AD) is a progressive neurodegenerative disorder of brain.", 'Application of behavioral, morphological and molecular biology, and other means were conducted to investigate the effect of allicin, which provide an experimental basis for the reliable application of allicin in the treatment of neurodegenerative diseases.'], ['Cross-sectional associations of PiB+/- status and DVR in motor-related regions (primary motor cortex, putamen, caudate) with gait characteristics were examined using linear regression, adjusted for age, sex, height, body mass index, gait speed and covariates (memory, executive function, visuoperceptual speed, depressive symptoms, cardiovascular risk, ApoE epsilon4, cerebrovascular burden, neurodegeneration, peripheral arterial disease, knee pain).'], ['Neurodegenerative dementias, like Alzheimer disease and dementia with Lewy bodies, are most common in the elderly, while traumatic brain injury and brain tumors are common causes in younger adults.', 'While the recent decade has seen significant advancements in molecular neuroimaging, in understanding clinico-pathologic correlation, and in the development of novel biomarkers, clinicians still await disease-modifying therapies for neurodegenerative dementias.'], ['These may increase with time and associate with late-onset degenerative diseases such as Parkinson disease, Alzheimer disease, and common cancers.'], ['Osteoarthritis (OA) is a degenerative joint disease involving both cartilage and synovium.'], ['With a rapidly aging global human population, finding a cure for late onset neurodegenerative diseases has become an urgent enterprise.', 'However, these efforts are hindered by the lack of understanding of what constitutes the phenotype of aged human microglia-the cell type that has been strongly implicated by genetic studies in the pathogenesis of age-related neurodegenerative disease.'], ['The disruption of this pathway, involved in maintaining mitochondrial integrity, could lead to several disorders (such as neurodegeneration) and aging.'], ['The importance of functional mitochondrial morphology is apparent as morphological defects are related to many human diseases including diabetes mellitus, liver disease, neurodegenerative diseases, aging and cancer.'], ['However, age-related neurodegenerative diseases do not fit the conceptual framework of frailty.', 'A terminology of frailty can and should be developed that connects aging, cognitive decline, and neurodegenerative disease.'], ['SASP in brain could contribute to age-related inflammation and chronic neurodegenerative diseases.'], ['The tendon was ruptured in zone IV with perforation of the gliding floor through which the degenerative pisiform was visible.'], ['Protein concentrations associated with anti-oxidation, aging, and in the prevention of neurotoxic agent production increased by at least 2-folds after the surgery, indicating that the brain may become less susceptible to neurodegeneration.'], ['Brain volume loss (BVL) has gained increasing interest for monitoring tissue damage in neurodegenerative diseases including multiple sclerosis (MS).'], ['In addition, I highlight advances toward the goal of developing drugs for several degenerative diseases of old age at once, including osteoporosis, by targeting shared mechanisms of aging.'], ['Deregulation in bidirectional network, particularly in aging population, leads to several neurodegenerative diseases such as dementia as a one of the major characteristics.'], ['In this review, we confer the promise of cannabidiol, an active ingredient of Cannabis sativa, for preventing or easing SE-induced neurodegeneration, neuroinflammation, cognitive and mood impairments, and the spontaneous recurrent seizures.'], ["We present a framework to explain how they may be integrated with current views on neurodegeneration, focusing mainly on sporadic late-onset neurodegenerative diseases (Parkinson's disease, Alzheimer's disease and amyotrophic lateral sclerosis).", 'We summarize existing views and data to present a model whereby the time of origin and spatial distribution of relevant somatic mutations, combined with any additional risk factors, may partly determine the development and onset age of sporadic neurodegenerative diseases.'], ["Moreover, microglia contribute to some neurodevelopmental disorders such as Nasu-Hakola disease (NHD), and to aged-associated neurodegenerative diseases, such as Alzheimer's disease (AD), Parkinson's disease (PD), and others.", 'This event determines alterations in the microglia activation status, associated with a chronic inflammation phenotype and with the loss of neuroprotective functions that lead to a greater susceptibility to the neurodegenerative diseases of aging.', 'Here, we review the role of the TREM2-DAP12 and CX3CL1-CX3CR1 axes in aged microglia and the involvement of these pathways in physiological CNS aging and in age-associated neurodegenerative diseases.'], ['Interestingly, mice overexpressing nonmutant forms of tau in the absence of frank neurodegeneration also demonstrated similar changes.'], ["Here, we attempted to address 1) the relation between myofiber type grouping and molecular regulators of neuromuscular junction (NMJ) stability; 2) the impact of motor unit remodeling on recruitment during submaximal contractions; 3) the prevalence and impact of motor unit remodeling in Parkinson's disease (PD), an age-related neurodegenerative disease; and 4) the influence of resistance exercise training (RT) on regulators of motor unit remodeling."], ['In theory, human diseases in which a specific cell type degenerates, such as neurodegenerative diseases, can be therapeutically addressed by replacement of the lost cells.'], ["Thus, upregulation of the Klotho gene can potentially alleviate the symptoms and/or prevent the progression of age-associated neurodegenerative diseases such as Alzheimer's disease and demyelinating diseases such as multiple sclerosis."], ['INTRODUCTION: Degenerative disease of the spine is a generic term encompassing a wide range of different disease processes, which leads to spinal instability; traumatic/neoplastic events can accelerate this aging process.'], ['It is a chronic degenerative disorder common in the elderly, particularly in women.'], ['In line with this, significance testing of the intersection of genes associated with these functional foods and GWAS hits for common biological functions (ageing and cognition) and non-communicable diseases (breast cancer, CVD, diabesity, neurodegeneration and psychiatric disorders) identified significant overlap between the EPA/DHA and breast cancer gene sets.'], ["With advancing age there is also a rise in the probability of developing a neurodegenerative disorder such as, e.g., amyotrophic lateral sclerosis, Huntington's disease, Parkinson's disease, or Alzheimer's disease.", 'In all these age-related neurodegenerative disorders, distinct neuron populations within specific brain regions are primarily affected.'], ["The current aging of the world population will increase the number of people suffering from brain degenerative diseases such as Alzheimer's disease (AD)."], ['Histological and neuroimaging studies have implicated the hippocampal region in neuropsychiatric disorders as well as in neurodegenerative diseases.'], ['The prevalence of neurodegenerative diseases of the posterior segment is increased as most of them are related with the elderly.', 'The purpose of the present review is to describe the use of microspheres in chronic neurodegenerative diseases affecting the retina and the optic nerve.', 'Also, a new use of the microspheres in the development of animal models of neurodegeneration of the posterior segment is described.'], ["Alzheimer's disease (AD) is a neurodegenerative disease with increasing incidence across the world and no cure at the present time.", 'The Chinese tree shrew (Tupaia belangeri chinensis) has a closer genetic affinity to primates relative to rodents, and can attain ages of 8 years or older, which represents another advantage for the study of neurodegenerative diseases such as AD compared to primates.'], ['Here, we study the interaction between sports inactivity with prodromal markers for neurodegeneration.'], ["INTRODUCTION: The diagnostic and classificatory performances of all combinations of three core (amyloid beta peptide [i.e., Abeta1-42], total tau [t-tau], and phosphorylated tau) and three novel (neurofilament light chain protein, neurogranin, and YKL-40) cerebrospinal fluid biomarkers of neurodegeneration were compared among individuals with mild cognitive impairment (n = 41), Alzheimer's disease dementia (ADD; n = 35), frontotemporal dementia (FTD; n = 9), and cognitively healthy controls (HC; n = 21), using 10-fold cross-validation."], ['MEASUREMENTS: The relationship between gait and cognition in aging and neurodegeneration was reviewed in the medical literature to highlight the role of brain motor control deficits in fall risk.'], ["As a result of the recently discovered relationship between circadian clock, sleep and neurodegeneration, new prospects of using melatonin for early intervention, to promote healthy physical and mental ageing, are of prime interest in view of the emerging link to the aetiology of Alzheimer's disease."], ['Loss of ATM causes ataxia telangiectasia, a neurodegenerative disorder with pleiotropic symptoms that include cerebellar dysfunction, cancer, diabetes, and premature aging.'], ['Supplementation of spermidine, an autophagy-inducing agent, has been shown to protect against neurodegeneration and cognitive decline in aged animal models.'], ['In this framework, solving current neurodegenerative diseases primarily associated with aging becomes more pressing than ever.', 'An initiative to implement the knowledge that is emerging from circuit-based approaches to tackle neurodegenerative disorders like PD will certainly be tremendously beneficial.'], ["Alzheimer's disease (AD) is a progressive neurodegenerative dysfunction characterized by memory impairment and brings a heavy burden to old people both in developing and developed countries."], ['Here we: (i) investigated longitudinal patterns of brain atrophy; (ii) tested whether atrophy is greatest in sulcal cortical regions; and (iii) showed how atrophy could be used to power intervention trials aimed at slowing neurodegeneration.'], ['This clinical pathologic conference case study illustrates the challenges of formulating clinicopathologic correlations in late-onset neurodegenerative diseases featuring cognitive-behavioral syndromes with underlying multiple proteinopathy.', "Studies on the co-existence and interactions of Alzheimer's disease (AD) with neurodegenerative non-AD pathologies in the aging brain are needed to understand the pathogenesis of neurodegeneration and to support the development of diagnostic biomarkers and therapies."], ['The neuropathology of LRRK2 mutation-related PD, including increased dopaminergic neurodegeneration and Lewy bodies, is indistinguishable from that of idiopathic PD.', "The present study provides the first in vivo and in vitro evidence demonstrating abnormal regulation of 5-HT1AR along with the manifestation of anxiety/depression-like, nonmotor symptom in PD related to LRRK2.SIGNIFICANCE STATEMENT Parkinson's disease (PD), the second most common neurodegenerative disorder, is clinically characterized by motor dysfunctions."], ['Modern medicine has increased the life expectancy, yet this has created an aged society that has more predisposition to degenerative disorders.'], ['Our result suggested that anxiety symptoms are predictive of episodic memory decline in cognitively healthy older adults and may be an early sign of neurodegenerative disorders.'], ["Aging restrains longevity and leads to neurodegenerative diseases including dementia, Alzheimer's disease and lacunar stroke.", 'The impact of aging and the risk of neurodegenerative diseases can be reduced by using probiotics, or preferably by combining probiotics and prebiotics, also known as synbiotics, that can drastically modify the composition of gut microbiome.'], ['Patients with degenerative neurological disease, limitation of therapeutic effort or on chronic mechanical ventilation were excluded.'], ["Mitochondrial dysfunction contributes to biological aging and a wide variety of disorders including metabolic diseases, premature aging syndromes, and neurodegenerative diseases such as Alzheimer's disease (AD) and Parkinson's disease (PD)."], ['Aging in the brain is caused by the loss of neurophysiologic functions due to neurodegeneration.'], ['Biomarkers of neurodegeneration (neurofilaments and tau) will be also be measured.'], ['Microglia and macrophages are the main non-neuronal subsets of myeloid origin in the brain, and are critical regulators in neurodegenerative disorders, where inflammation is a key factor.'], ['Degenerative spine disease has increased in incidence in aging societies, as has the number of older adult patients undergoing spinal surgery.'], ['The aging process is driven by interrelated mechanisms that lead to the emergence of characteristic phenotypes that include changes in body composition, energy production and utilization imbalance, homeostatic dysregulation, and neurodegeneration and loss of neuroplasticity.'], ['Primary progressive apraxia of speech (PPAoS) is a neurodegenerative syndrome characterized by speech apraxia at its onset; as it progresses, it often evolves into total mutism.'], ["Alzheimer's disease (AD) is a neurodegenerative disease that is imposing an increasing burden on society."], ['Common risk factors were heart failure 87 (56.5%), old age (>75 years) 66 (42.8%), hypertension 47 (30.5%), dilated cardiomyopathy 23 (14.9%), degenerative multivalvular heart disease 23 (14.9%) and ischemic heart disease (13.6%).'], ['Osteoarthritis (OA) is a progressively degenerative joint disease, with a very high prevalence rate that is expected to increase worldwide with the ageing of the population.'], ["BACKGROUND: Huntington's disease (HD) is a progressive neurodegenerative disorder that results in a gradual decline in mobility and balance."], ['METHODS: A retrospective review of prospectively collected clinical data of patients over 75 years of age, who underwent mitral valve surgery for degenerative disease, between 2010 and 2013, was carried out.'], ['All completed 2 + cognitive evaluations (maximum = 22), died, and underwent neuropathologic examinations to identify Alzheimer disease (AD), other neurodegenerative diseases, and vascular pathologies.'], ['Most neurodegenerative diseases are proteinopathies, which are characterized by the aggregation of misfolded proteins.'], ['Degenerative diseases are becoming more common with increasing life expectancy of the human population.', 'More than 40% of adults over 60 years old present a combination of risk factors, described as metabolic syndrome, which significantly increases the tendency for developing degenerative diseases, and some types of cancers.'], ['The objective of the proposed study was to assess the neurocognitive and psychological effects of caring for a person with dementia or a related neurodegenerative disease in a sample of Canadian informal caregivers.', 'METHODS: Fifty-seven informal caregivers of a person with dementia or a related neurodegenerative disease (mean age = 66.26, SD = 7.55) and 97 non-caregivers (mean age = 69.16, SD = 4.84) were recruited.'], ['There is a biological plausibility from animal models that vitamin D may influence neurodegenerative disorders, through several mechanisms.'], ['Musculoskeletal conditions of the spine in the older patient commonly include osteoarthritis and spinal stenosis, and the result of these degenerative diseases includes pain, stiffness and a decreased ability to engage in everyday activities.'], ['TEs have functional roles in a variety of biological phenomena such as cancer, neurodegenerative disease, and aging.'], ['It has long been hypothesized that aging and neurodegeneration are associated with somatic mutation in neurons; however, methodological hurdles have prevented testing this hypothesis directly.', 'We used single-cell whole-genome sequencing to perform genome-wide somatic single-nucleotide variant (sSNV) identification on DNA from 161 single neurons from the prefrontal cortex and hippocampus of 15 normal individuals (aged 4 months to 82 years), as well as 9 individuals affected by early-onset neurodegeneration due to genetic disorders of DNA repair (Cockayne syndrome and xeroderma pigmentosum).', 'sSNVs increased approximately linearly with age in both areas (with a higher rate in hippocampus) and were more abundant in neurodegenerative disease.'], ["Parkinson's disease (PD) and Alzheimer's disease (AD) are the most common age-related neurodegenerative disorders."], ['Emerging and preliminary evidence demonstrates, however, a U-shaped risk at both low and high iron status for birth and infant adverse health outcomes including growth, preterm birth, gestational diabetes, gastrointestinal health, and neurodegenerative diseases during aging.'], ['A possible relationship between glaucoma and neurodegenerative diseases such as Alzheimer Disease has been suggested.', 'common features, risk factors and pathophysiological mechanisms gathered in the recent literature do suggest that Alzheimer Disease and glaucoma can be considered both age-related neurodegenerative diseases that may co-exist in the elderly.'], ['These changes predispose HIV-infected persons to comorbid conditions that have been linked to immunosenescence and inflamm-ageing, such as atherosclerosis and cardiovascular disease, neurodegeneration, and cancer.'], ['Amyloid formation is associated with a number of neurodegenerative diseases that affect the independence and quality of life of aging populations.'], ["Both normal aging and neurodegenerative disorders such as Alzheimer's disease (AD) cause morphological changes of the brain.", 'To facilitate making this distinction and thus aid the diagnosis of neurodegenerative disorders, we propose a method for developing a spatio-temporal model of morphological differences in the brain due to normal aging.'], ["Previous evidence from human patients and animal models of neurodegeneration has highlighted the importance to record simultaneously the pattern electroretinogram (P-ERG) and visual evoked cortical potentials (VEPs) to investigate retinal and post-retinal sites of neurodegeneration.In view of the increasing importance of research on experimental models of neurodegenerative diseases, we present here the parametric properties of visual evoked responses in animal models of glaucoma and Alzheimer's disease.", "Glaucoma and Alzheimer's disease (AD) are two distinct multifactorial neurodegenerative and progressive diseases, primarily affecting the elderly."], ['Impairment of TGF-beta1 signaling is associated with exacerbated Abeta deposition and neurofibrillary tangle formation, which increases neurodegeneration.', "Aging and chronic inflammation reduce the canonical TGF-beta1/Smad signaling, facilitating cytotoxic activation of microglia and microgliamediated neurodegeneration This review gathers together evidence for a neuroprotective role of TGF-beta in Alzheimer's disease."], ["Alzheimer's disease is a progressive neurodegenerative disease for which there is no cure and only a few treatments providing little relief."], ['The intrinsic vulnerabilities of these neurons are unclear, and their contribution to neurodegeneration is unknown.'], ['Individuals with a reduction in CSF Abeta levels (an indicator of amyloid accretion into neuritic plaques) as well as evident tau pathology (believed to be linked to neurodegeneration) exhibited lower subiculum volume, lower fornix microstructural integrity, and a trend towards lower cognitive score than individuals who showed only reduction in CSF Abeta.'], ["PSD95 levels are diminished in ageing and neurodegenerative disorders, including Alzheimer's disease and Huntington's disease."], ['In particular, the hyperactivation of the transcription nuclear factor kappaB (NF-kappaB), if is not counterbalanced by the following activation of the nuclear factor (erythroid-derived 2)-like 2 (NFE2L2 or Nrf2), increases the production of oxidative catabolites, as the advanced glycation end products (AGE), which play a key role in the progression of different types of cancer and other degenerative diseases.'], ['Recent studies indicate disruptions to the circadian system in brain injury and neurodegeneration.'], ['FoxO transcription factors oversee proinflammatory pathways, affect nervous system amyloid (Abeta) production and toxicity, lead to mitochondrial dysfunction, foster neuronal apoptotic cell death, and accelerate the progression of degenerative disease.', 'CONCLUSION: Given the ability of FoxOs to not only promote apoptotic cell death in the nervous system, but also through the induction of autophagy offer protection against degenerative disease that can lead to dementia, a fine balance in the activity of FoxOs may be required to target cognitive loss in individuals.'], ['INTRODUCTION: Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease causing an upper and lower motor neuron loss.'], ["Parkinson's disease is a common neurodegenerative disorder in the elderly which when present has a significant influence on surgical management."], ['As more people live longer, age-related neurodegenerative diseases are an increasingly important societal health issue.'], ['Autophagy and DNA repair are biological processes vital for cellular homeostasis maintenance and when dysfunctional, they lead to several human disorders including premature aging, neurodegenerative diseases, and cancer.'], ['The current consensus is that ROS cause oxidative stress, damaging mitochondria and resulting in an energetic crisis that triggers neurodegenerative diseases and accelerates aging.'], ['The accumulation of advanced glycation end products (AGEs) occurs in ageing and in many degenerative diseases as a final outcome of persistent oxidative stress on cells and organs.'], ['Declining activity of AMPK, a critical cellular energy sensor, may therefore contribute to neurodegeneration.'], ['The aging process is the major driver of morbidity and mortality, steeply increasing the risk to succumb to cancer, cardiovascular disease, infection and neurodegeneration.'], ['mRNA turnover controls gene expression under various conditions in aging and neurodegenerative diseases.', 'Polyglutamine (polyQ) diseases and intranuclear inclusion body disease (INIBD) are neurodegenerative diseases characterized by the formation of nuclear inclusions.'], ['Additionally, ursolic acid is capable of modulating the monoaminergic system, an effect that might be involved in its ability to prevent mood and cognitive dysfunctions associated with neurodegenerative and psychiatric conditions.'], ['We identified three multimorbidity patterns, which were mainly labelled as degenerative disorders, digestive/respiratory disorders, cardiovascular/metabolic disorders, respectively.'], ['Patients with minor stroke had less early neurological deterioration and better functional outcome.'], ['OBJECTIVE: To clarify the temporal relationship between systemic inflammation and neurodegeneration, we examined whether a higher level of circulating inflammatory markers during midlife was associated with smaller brain volumes in late life using a large biracial prospective cohort study.', 'CONCLUSIONS: Our prospective findings provide evidence for what may be an early contributory role of systemic inflammation in neurodegeneration and cognitive aging.'], ['Together with previous observational studies on cognitive function, this study lends support to the notion that high serum folate concentrations in older people with VB12 deficiency may be associated with increased neurodegeneration.'], ['This neurodegenerative disorder needs advancement in research and development which can help patients with PD to lead a normal life.'], ['Our findings of cortical sulcal changes in normal ageing could provide a reference for studies of neurocognitive disorders, including neurodegenerative diseases, in the elderly.'], ['Expression of the UPR target genes was elevated in degenerative IVDs in both humans and rats.'], ['BACKGROUND: Degenerative diseases are a major public health concern for the aging population and mesenchymal stem cells (MSCs) have great potential for treating many of these diseases.'], ['OBJECTIVE: To investigate the correlation between the sagittal spinopelvic alignment and the functional outcomes after long instrumented fusion for degenerative thoracolumbar spinal disease.', 'METHODS: Between 2009 and 2013, data of 120 patients with multilevel degenerative thoracolumbar spinal disease who underwent long instrumented fusion were collected retrospectively.'], ["Parkinson's disease (PD) is an age-related neurodegenerative disease characterized by loss of dopaminergic neurons associated with neuroinflammation."], ["Misfolded beta-sheet structures of proteins leading to neurodegenerative diseases like Alzheimer's disease (AD) and Parkinson's disease (PD) are in the spotlight since long.", 'A detailed review of the latest status regarding the interrelationship between functional amyloids, pathogenic amyloids and misfolded prions and therapeutic assessment of functional amyloids for the treatment of neurodegenerative diseases can help identify an alternative medication for neurodegeneration.'], ['This finding not only adds to the recent reports that tau pathology is a feature of these neurodegenerative diseases, but also that tau pathology can manifest in healthy neural tissue transplanted into the brains of patients with two distinct neurodegenerative disorders.'], ['Unlike other synucleinopathies, in this disorder the synaptic protein, alpha-synuclein (alpha-syn), predominantly accumulates in oligodendroglial cells (and to some extent in neurons), leading to maturation defects of oligodendrocytes, demyelination, and neurodegeneration.'], ["Neurodegenerative diseases pose an extraordinary threat to the world's aging population, yet no disease-modifying therapies are available.", 'Although genome-wide association studies (GWASs) have identified hundreds of risk loci for neurodegeneration, the mechanisms by which these loci influence disease risk are largely unknown.', 'Here, we investigated the association between common genetic variants at the 7p21 locus and risk of the neurodegenerative disease frontotemporal lobar degeneration.', 'Finally, we show that genetic variants associated with risk of neurodegenerative diseases beyond frontotemporal lobar degeneration are enriched in CTCF-binding sites found in brain-relevant tissues, implicating CTCF-mediated gene regulation in risk of neurodegeneration more generally.'], ['BACKGROUND AND OBJECTIVES: A huge number of solutions based on computational systems have been recently developed for the classification of cognitive abnormalities in older people, so that individuals at high risk of developing neurodegenerative diseases, such as Cognitive Impairment and Alzheimer?s disease, can be identified before the manifestation of the diseases.', 'The primary objective is to use a regression model to analyze the data set aiming to check which parameters are necessary to achieve high accuracy in the diagnosis of neurodegenerative disorders.', 'CONCLUSIONS: The presented approach is a valuable tool for identifying patients with dementia or MCI and for supporting the clinician in the diagnostic process, by providing an outstanding support decision tool in the diagnostics of neurodegenerative diseases.'], ['Transcriptomic data have become a fundamental resource for stem cell (SC) biologists as well as for a wider research audience studying SC-related processes such as aging, embryonic development and prevalent diseases including cancer, diabetes and neurodegenerative diseases.'], ['d-galactose, a derivative of lactose, is used in animal studies to induce neurodegeneration.'], ["BACKGROUND: Decreased circulating tryptophan (Trp) levels are frequently observed in elderly patients with neurodegenerative disease including Alzheimer's disease."], ["These latency measures have potential to serve as neurocognitive biomarkers of Alzheimer's disease and other insidious neurodegenerative disorders."], ["Numerous epidemiological studies have strongly suggested that multinutrient approaches using the Mediterranean diet (Med diet), dietary approach to systolic hypertension (DASH) and the Mediterranean-DASH diet intervention for neurodegenerative delay (MIND) are associated with a lower risk of cognitive impairment, MCI and Alzheimer's disease in older persons."], ['Dysregulation of mitophagy can lead to human pathologies such as neurodegenerative disorders and contributes to the aging process.'], ["We likewise address the role of GM in neurodegenerative diseases such as Parkinson's and Alzheimer's, and its possible therapeutic use, taking advantage of the fact that centenarians are characterized by an extreme (healthy) phenotype versus patients suffering from age-related pathologies."], ['OBJECTIVE: To estimate the prevalence of elevated brain amyloid and reduced cortical thickness (as a marker for neurodegeneration) in a defined population.'], ["Alzheimer's disease (AD) is a neurodegenerative disorder that preferentially affects individuals of advanced age."], ['Loss of neuronal proteostasis, a common feature of the aging brain, is accelerated in neurodegenerative disorders, including different types of tauopathies.'], ['We used global amyloid from Pittsburgh compound B PET, entorhinal cortex tau uptake (ERC-tau) from tau-PET, and neurodegeneration in AD signature regions from MRI and FDG-PET as surrogates for AD pathophysiology.', 'Using structural equation models (SEMs), we assessed the impact of vascular health on AD biomarker cascade (amyloid leads to tau leads to neurodegeneration) after considering the direct and indirect age, sex, and apolipoprotein E effects.', 'RESULTS: CMC+ participants had significantly greater neurodegeneration than CMC- participants but did not differ by amyloid or ERC-tau.', 'The SEMs showed that (1) vascular health had a significant direct and indirect impact on neurodegeneration but not on amyloid; and (2) vascular health, specifically the presence of hyperlipidemia, had a significant direct impact on ERC-tau.', 'INTERPRETATION: Vascular health had quantifiably greater impact on neurodegeneration in AD regions than on amyloid deposition.'], ['In addition, its short lifespan and importance in the field of aging make it an ideal organism for modeling age-related neurodegenerative disease.', 'As such, this nematode system has demonstrated its value in predicting functional modifiers of human neurodegenerative disorders.', 'Specifically, we present how the causative neurotoxic peptides, amyloid-beta and tau, contribute to disease-like neurodegeneration in C. elegans and how they translate to human disease.', "As technological advances improve the prospects for intervention, the rapidity, unparalleled accuracy, and scale that C. elegans offers researchers for defining functional modifiers of neurodegeneration should speed the discovery of improved therapies for Alzheimer's disease."], ['Recent Advances: Recent work described here has illustrated the power of systems biology to inform our understanding of aging through the study of (i) diet restriction, (ii) neurodegenerative disease, and (iii) biomarkers of aging.'], ['PURPOSE: To determine if Tai Chi (TC) has an impact on long-range correlations and fractal-like scaling in gait stride time dynamics, previously shown to be associated with aging, neurodegenerative disease, and fall risk.'], ['However, despite being the most prevalent neurodegenerative disorder, the number one communication disorder, and one of the top three chronic medical conditions of our aged population; little research has been conducted on the potential role of inflammation in age-related hearing loss (ARHL).'], ["OBJECTIVE: Alzheimer's disease (AD) is a progressive and debilitating neurodegenerative disease; a major health concern in the ageing population with an estimated prevalence of 46 million dementia cases worldwide."], ['The Niemann-Pick type C is a rare neurodegenerative disease that results from loss-of-function point mutations in NPC1 or NPC2, which affect the homeostasis of sphingolipids and sterols in human cells.'], ['Calcifications (vascular wall and parenchymal) occur in the normal aging brain and in neurodegeneration; some associated genes are already described.'], ["Mutation in the triggering receptor expressed on myeloid cells (TREM) 2 gene has been identified as a risk factor for several neurodegenerative diseases including Alzheimer's disease (AD)."], ['However, it is not clear how to implement this in clinical practice and the Belgian law on driving is rather vague in its referral to neurodegenerative brain diseases in general nor does it provide clear-cut instructions for dementia or AD compared to for example driving for patients with epilepsy and as such does not prove to be very helpful.'], ["Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by the presence of extracellular amyloid plaques consisting of Amyloid-beta peptide (Abeta) aggregates and neurofibrillary tangles formed by aggregation of hyperphosphorylated microtubule-associated protein tau."], ['BACKGROUND: MAPT mutations cause neurodegenerative diseases such as frontotemporal dementia but, strikingly, patients with the same mutation may have different clinical phenotypes.'], ['AD biomarkers were measured with a composite score composed of measures of amyloid, phosphorylated tau, and neurodegeneration.'], ['With increased life expectancy comes increased risk of developing age-related cognitive decline and neurodegenerative diseases, such that an increasing proportion of life may be lived with cognitive impairment as age increases.'], ['BACKGROUND: Modern management of human immunodeficiency virus (HIV) infection has afforded patients longevity while increasing the burden of arthroplasty procedures because of the increased risk of osteonecrosis, fragility fractures, and degenerative joint disease.'], ['Age-related cellular, biochemical, and molecular changes in the hippocampus lead to cognitive impairments and greater vulnerability to neurodegenerative disease that varies between the sexes.'], ["The locus coeruleus (LC), a major origin of noradrenergic projections in the central nervous system (CNS), may serve a critical role in the pathogenesis of neurodegenerative disorders such as Alzheimer's disease (AD) and Parkinson's disease (PD).", 'The findings presented demonstrate in vivo T1-weighted FLASH imaging may be used to characterise signal intensity changes across the entire rostrocaudal length of the LC (a corresponding standardised LC map is available for download), which may help to identify how the human LC is differentially affected in aging and neurodegenerative disease.'], ['Levels of vascular endothelial growth factor (VEGF), intercellular adhesion molecule-1 (ICAM-1), and vascular cell adhesion molecule-1 (VCAM-1) have been related to aging and neurodegeneration, but their role in schizophrenia remains uncertain.'], ['Recent attempts have been made to redefine the diagnostic criteria of AD to include markers of neurodegeneration - measurable by FDG-PET - and markers of amyloid accumulation - measurable by amyloid-PET.'], ['However, the contribution of LINE1 to genomic variability during normal aging and in age-related neurodegenerative diseases is poorly understood.'], ["Parkinson's disease (PD) is an aging-associated neurodegenerative disease affecting millions worldwide.", 'The mechanism whereby cholesterol metabolism functionally impacts neurodegeneration induced by alpha-synuclein is undefined.'], ['Neurological deterioration (ND) was defined as an increase of National Institutes of Health Stroke Score (NIHSS) >= 4 points.'], ['Evaluation of behavior and cognition in rodent models underpins mechanistic and interventional studies of brain aging and neurodegenerative diseases, especially dementia.', 'Dietary interventions have been shown to influence various cognitive and behavioral tests in rodents indicating that nutrition can influence brain aging and possibly neurodegeneration.'], ['Serum uric acid (SUA) is an abundant natural antioxidant capable of reducing cellular oxidation, a major cause of neurodegenerative disease.'], ['Pathology has so far not convincingly proved neurodegeneration for the condition but possibly adaptive changes of the brain particularly in the cerebellum are likely.'], ['Hence, controlling mitochondrial dynamics and autophagic flux via AMPK activation might be a useful therapeutic strategy in neurodegenerative diseases to reinstate energy homeostasis and degrade misfolded proteins.', 'In this review article, we discuss briefly the role of AMPK signaling in energy homeostasis, the structure of AMPK, activation mechanisms of AMPK, regulation of AMPK, the role of AMPK in autophagy, the role of AMPK in neurodegenerative diseases, and finally the role of autophagic flux in prion diseases.'], ['Several pathologies such as neurodegeneration and cancer are associated with aging, which is affected by many genetic and environmental factors.'], ['Furthermore, MRI and histological detection were employed to provide more solid evidence that RES injection in an IVDD rabbit model effectively retards the degenerative process of the intervertebral discs in vivo.'], ['Aging is a primary risk factor for both neurodegenerative disorders (NDs) and tumors such as adult-onset brain tumors.', 'Since NDs and tumors are severe, disabling, progressive and often incurable conditions, they represent a pressing problem in terms of human suffering and economic costs to the healthcare systems.', 'Among these compounds, polyphenols are considered to be one of the most bioactive agents in neurodegeneration and tumor prevention.'], ['One of the unsolved mysteries of AD is how the presence of ApoE4 elicits this age-associated, currently incurable neurodegenerative disease.'], ['Up to 15% of the patients developed rapidly progressive cognitive deterioration, which further complicated the differential diagnosis with a neurodegenerative disorder.'], ['Aging is the main risk factor for many chronic degenerative diseases and cancer.'], ['DHA and specifically one of its derivatives known as neuroprotectin D-1 (NPD-1), has neuroprotective properties against brain aging, neurodegenerative diseases and injury caused after brain ischemia-reperfusion episodes.'], ["Taking into account that connexin-43 (Cx43) (together with Cx30) is heavily expressed in astrocytes and that drebrin supports cell-cell contacts, the understanding of details of how brain cells live and die reveals molecular pathology involved in neurodegeneration, Alzheimer's disease (AD), other cognitive disorders, and aging.Bidirectional connexin channels are permeable to Ca2+ ions, IP3, ATP, and cAMP."], ['The closing section highlights the clinical potential of behavioral and neural markers of spatial navigation, with a particular emphasis on neurodegenerative disorders.'], ['Some evidence suggests that neurodegeneration related to aging and disease may preferentially affect the left-usually language- and motor-dominant-hemisphere.', "Here, we used activation likelihood estimation meta-analysis to assess gray matter (GM) loss and its lateralization in healthy aging and in neurodegeneration, namely, mild cognitive impairment (MCI), Alzheimer's dementia (AD), Parkinson's disease (PD), and Huntington's disease (HD).", 'Regions with asymmetric GM decline were located in areas primarily affected by neurodegeneration.'], ["Alzheimer's disease is a major neurodegenerative disorder that leads to severe cognitive deficits in the elderly population."], ["These findings indicate that glucosylsphingosine promotes pathological aggregation of alpha-synuclein, increasing PD risk in GD patients and carriers.SIGNIFICANCE STATEMENT Parkinson's disease (PD) is a prevalent neurodegenerative disorder in the aging population."], ['A growing interest raised around the role of signal transduction systems in a number of human diseases including neurodegenerative diseases, with special regard to the systems related to the phosphoinositide (PI) pathway and AD.'], ['Experimental studies will be instrumental to determine the functional effect of positively selected sites in REST and the role of REST variants in neuropreservation/neurodegeneration.'], ['Amyotrophic lateral sclerosis and frontotemporal lobar degeneration with ubiquitin-positive inclusions are neurodegenerative disorders that share the cytosolic deposition of TDP-43 (TAR DNA-binding protein 43) in the CNS.', 'The well-documented decrease in the efficiency of these clearance systems in aging and neurodegeneration, as well as the genetic evidence that many of the familial forms of TDP-43 proteinopathies involve genes that are associated with them, suggest that a failure of these protein degradation systems is a major factor that contributes to the onset of TDP-43-associated disorders.'], ['These individuals often exhibit other symptoms including progeria and neurodegeneration.', 'This chapter focuses on therapeutic strategies designed to target aspects of the DNA damage response, and examines emerging themes demonstrating mechanistic overlap between DNA repair and neurodegeneration.'], ["The association of lysosomal dysfunction and neurodegeneration has been documented in several neurodegenerative diseases, including Alzheimer's Disease (AD)."], ['FUNDING: Medical Research Council (G9901400) and (G06010220), with support from the National Institute for Health Research Comprehensive Local research networks in West Anglia and Trent, UK, and Neurodegenerative Disease Research Network in Newcastle, UK.'], ["Parkinson's disease (PD) is a common neurodegenerative disorder, with ageing being a major risk factor."], ['This information might be critical to avoid neurological deterioration after cervical laminoplasty or laminoforaminotomy.'], ['Neuroinflammation- and neurodegeneration-induced nerve injury may represent important components of neuropsychiatric lupus (NPSLE).'], ['Accumulation of intracellular misfolded or damaged proteins is associated with both normal aging and late-onset degenerative diseases.', 'Our findings highlight the importance of lysosome acidification in cellular surveillance mechanisms and establish a model for exploring strategies to mitigate neurodegeneration by boosting lysosomal function.'], ["Lewy body dementias are the second most common cause of neurodegenerative dementia in the elderly after Alzheimer's disease (AD)."], ['Amyotrophic lateral sclerosis (ALS) is a devastating late-onset neurodegenerative disorder in which only a small proportion of patients carry an identifiable causative genetic lesion.'], ["Parkinson's disease is characterized by progressively distributed Lewy pathology and neurodegeneration."], ['Since UCP2 is expressed in several brain regions, we investigated in this study whether UCP2 polymorphisms might 1) affect occurrence of neurodegenerative or mental health disorders and 2) affect measures of brain structure and function.', 'No association of UCP2 polymorphisms with the occurrence of neurodegenerative disorders or grey and white matter structure or resting-state functional connectivity was observed.'], ['BACKGROUND: The Mediterranean dietary pattern has been associated with a decreased risk of many degenerative diseases and cognitive function in particular; however, relevant information from Mediterranean regions, where the prototype Mediterranean diet is typically adhered to, have been very limited.'], ['RESULTS: CoQ10 has been applied in different types of neurodegeneration.'], ['Heat shock protein 70, encoded by the HSPA1A gene in humans, is a key component of the machinery that protects neuronal cells from various stress conditions and whose production significantly declines during the course of aging and as a result of several neurodegenerative diseases.'], ['The molecular changes observed in this study are known signs of neurodegeneration and brain aging.'], ['Excessive production of mitochondrial reactive oxygen species (mROS) is strongly associated with mitochondrial and cellular oxidative damage, aging, and degenerative diseases.', 'Recent studies show that the activation of the mitochondrial permeability transition pore (mPTP), which is triggered by mROS and mitochondrial calcium overloading, is enhanced in aged animals and humans and in aging-related degenerative diseases.'], ['An improper response to DNA damage can lead to genome instability, accelerate the aging process and ultimately cause various human diseases, including cancers and neurodegenerative disorders.'], ['We conclude that further classification and longitudinal studies are required to shed more light into the potential role of neurogranin as a pathophysiological biomarker of neurodegenerative diseases.'], ["Reserve in aging and Alzheimer's disease (AD) is defined as maintaining cognition at a relatively high level in the presence of neurodegeneration, an ability often associated with higher education among other life factors.", 'Reserve was quantified as residualized memory performance, accounted for gender and proxies of neurodegeneration (age, hippocampus atrophy, and APOE genotype).'], ['BACKGROUND: Driving is a key functional activity for many older adults, and changes in routine driving may be associated with emerging cognitive decline due to early neurodegenerative disease.'], ["METHODS: In light of the significant role circadian rhythm can hold over the body's normal physiology as well as disease processes, we examined and discussed the impact circadian rhythm and clock genes hold over lifespan, neurodegenerative disorders, and tumorigenesis.", 'CONCLUSION: Future targeting of the pathways of autophagy, mTOR, SIRT1, and Wnt that control mammalian circadian rhythm may hold the key for the development of novel and effective therapies against aging- related disorders, neurodegenerative disease, and tumorigenesis.'], ['Emerging evidence indicates that autophagy dysfunction is closely related to various human diseases including cancer, aging, myopathies and neurodegenerative disorders.'], ["This article brings together nutrition-associated therapeutic approaches with the fields of aging, immunology, neurodegenerative disease, and cancer to propose ways in which diet and nutrition can work with standard-of-care and integrated medicine to help improve the brain's function as it ages."], ['The relationship between sarcopenia and postoperative outcomes after surgery for degenerative spine disease (DSD) has not been investigated.'], ["Alzheimer's disease (AD) is a common, progressive, fatal neurodegenerative disorder, which will play an increasingly important role both socially and financially in the aging populations."], ['BACKGROUND: Elderly patients are increasingly operated for spinal degenerative diseases.'], ["We examined formalin-fixed 10-mm thick coronal brain blocks from 10 CAA patients (five were also diagnosed with Alzheimer's disease, three with dementia with Lewy bodies, and two with CAA only) with dementia and six non CAA patients with neurodegenerative disease."], ["Alzheimer's disease (AD) is an aging-related neurodegenerative disease and accounts for majority of human dementia."], ['This subtype of frailty is deemed important, as it may represent a prodromal phase for neurodegenerative diseases and is potentially a suitable target for early intervention.'], ['Mutations in TDP-43 are associated with proteinaceous inclusions in neurons and are believed to be causative in neurodegenerative diseases such as frontotemporal dementia or amyotrophic lateral sclerosis.'], ['Recently, the increasing economic burden of healthcare caused by people ageing and the increasing incidence of degenerative diseases (e.g.'], ['BACKGROUND AND PURPOSE: Breakdown of BBB integrity occurs in dementia and may lead to neurodegeneration and cognitive decline.'], ['Biochemical risk assessment studies of chemicals that induce DNA lesions are important, because lesions in genomic DNA frequently result in cancer, neurodegeneration, and aging in humans.', 'Individuals with NER-defective xeroderma pigmentosum (XP), in which bulky DNA lesions are not efficiently removed, are cancer-prone and suffer neurodegeneration.'], ['Recent studies suggest that aortic stenosis is not a passive degenerative disease, but an active process involving several pathways, including lipid infiltration, chronic inflammation, fibrosis formation, osteoblast activation, and active valve mineralisation.'], ['Degenerative disease is the most common etiology of MR, AS, and AR, though these forms of VHD also can be caused by congenital valve defects, systemic inflammatory diseases, endocarditis, and many other conditions.'], ['Microglia are essential for CNS homeostasis and innate neuroimmune function, and play important roles in neurodegeneration and brain aging.'], ['CONCLUSIONS: The CAIDE Dementia Risk Score was related to indicators of cerebrovascular changes and neurodegeneration on MRI, and cognition.'], ['On the other side of the coin, many neurodegenerative diseases are associated with epigenetic dysregulation.', "We will discuss examples in the context of psychiatric disorders, including schizophrenia and posttraumatic stress disorders, and also dementia or Alzheimer's disease as the most frequent neurodegenerative disease."], ["AIMS: To investigate the roles of N-myc downstream-regulated gene 2 (NDRG2) in the pathology of aging and neurodegenerative disease such as Alzheimer's disease (AD)."], ['Obesity has been associated with increased chronic neuroinflammation and augmented risk of neurodegeneration.'], ["Alzheimer's disease (AD) is a debilitating age-related neurodegenerative disorder."], ['Knee osteoarthritis (KOA) is a common chronic degenerative disease of the elderly.'], ['The prion paradigm is increasingly invoked to explain the molecular pathogenesis of neurodegenerative diseases involving the misfolding and aggregation of proteins other than the prion protein (PrP).'], ['The success of antioxidant therapy in hyperthyroidism implies that disease is mediated by oxidative stress, which is known as one of the causing agents of ageing, degenerative diseases, and cancer.'], ['In recent years, with the increase in degenerative diseases and the aging population in advanced countries, demands for medical care of older or solitary people have increased continually in hospitals and healthcare institutions.'], ['Together, these systems create a highly integrated molecular communication network that link systemic imbalances with the development of neurodegeneration including insulin regulation, fat metabolism, oxidative markers and immune signaling.', 'Age is a common factor in the development of neurodegenerative disease and probiotics prevent many harmful effects of aging such as decreased neurotransmitter levels, chronic inflammation, oxidative stress and apoptosis-all factors that are proven aggravators of neurodegenerative disease.'], ['A review of all four of these patients with an overgrowth phenotype and PDGFRB mutations revealed postnatal skeletal overgrowth, premature aging, cognitive impairment, neurodegeneration, and a prominent connective tissue component to this complex phenotype.'], ['Helping neurons to compensate for proteotoxic stress and maintain function over time (neuronal compensation) has therapeutic potential in aging and neurodegenerative disease.'], ['These data suggest that SIRT3 is not critical to fight infections and support the safety of SIRT3-directed therapies based on SIRT3 activators or inhibitors for treating metabolic, oncologic and neurodegenerative diseases without putting patients at risk of infection.'], ['BACKGROUND: Huntington disease (HD) is a fatal neurodegenerative disorder involving reduced muscle coordination, mental and behavioral changes, and testicular degeneration.'], ["While rare in children, frequency increases with normal ageing and is high in Alzheimer's disease, dementia with Lewy bodies and other neurodegenerative disorders."], ['Indeed, aging is associated with growing risk factors for illness associated with societal conditions (isolation, maltreatment), and neurodegenerative diseases.'], ['Some of these changes are physiological and parallel the normal aging process, while others might represent pathophysiological mechanisms underlying neurodegenerative disorders.'], ['Brain inflammaging is increasingly considered as contributing to age-related cognitive loss and neurodegeneration.', 'Here, in the mouse model of brain senescence SAMP8, we tested the effects of proinsulin, a promising neuroprotective agent that was previously proven to be effective in mouse models of retinal neurodegeneration.'], ["Additionally, a number of clinical applications of creatine supplementation have been studied involving neurodegenerative diseases (e.g., muscular dystrophy, Parkinson's, Huntington's disease), diabetes, osteoarthritis, fibromyalgia, aging, brain and heart ischemia, adolescent depression, and pregnancy."], ['Emerging evidence suggests that cell senescence plays an important role in aging-associated diseases including neurodegenerative diseases.'], ["Alzheimer's disease (AD) is characterized by substantial neurodegeneration, including both cortical atrophy and loss of underlying white matter fiber tracts.", 'Linear mixed effects models were performed to test the hypothesis that biomarkers for AD, neurodegeneration, and inflammation, or two-year change in those biomarkers, would be associated with worse white matter health overall and/or progressively worsening white matter health over time.', 'These findings suggest that biomarkers for AD, neurodegeneration, and inflammation are potentially important indicators of declining white matter health in a cognitively healthy, late-middle-aged cohort.'], ["Parkinson's disease (PD) is a common neurodegenerative condition affecting more than 8 million people worldwide."], ["Potential individual-level predictors that were related to Alzheimer's disease pathology or genetic risk, neurodegeneration, and vascular risks were collected at baseline."], ['We assessed aging-related neurodegenerative lesions, i.e., misfolded proteins, associated with dementia such as hyperphosphorylated tau (HPtau), Abeta, alpha-synuclein (alphaS), and phosphorylated transactive DNA binding protein 43 (pTDP43) seen in the brain and IAPP seen in the pancreas in subjects with and without DM applying immunohistochemical techniques.'], ['Cervical degenerative disease is one of the most common spinal disorders worldwide, especially in older people.', 'Anterior cervical corpectomy and fusion (ACCF) is a useful method for the surgical treatment of multi-level cervical degenerative disease.', 'Therefore, we designed a non-fusion cervical joint system, namely an artificial cervical vertebra and intervertebral complex (ACVC), to provide a novel treatment for multi-level cervical degenerative disease.', 'In conclusion, ACVC-HA brings new insight to treat cervical degenerative disease.'], ['The rising prevalence of progressive neurodegenerative diseases coupled with increasing longevity poses an economic burden at individual and societal levels.', 'There is currently no effective cure for the majority of neurodegenerative diseases and disease-affected tissues from patients have been difficult to obtain for research and drug discovery in pre-clinical settings.', "Here we review findings from iPSC-based modeling of selected neurodegenerative diseases, including Alzheimer's disease, frontotemporal dementia and spinocerebellar ataxia."], ["SIRT1, the best studied mammalian SIRT is involved in many physiological and pathological processes and changes in SIRT1 have been implicated in neurodegenerative disorders, with SIRT1 having a suggested protective role in Parkinson's disease.", 'CONCLUSIONS: These findings suggests a negative effect of oxidative stress in neurodegenerative disorders and possibly explain the reduced activity of SIRT1 in neurodegenerative disorders.'], ['Bullous pemphigoid, a common autoimmune blister disease in the elderly, is always heralded by pruritic eczematous dermatitis and is often associated with neurodegenerative diseases.', 'We hypothesized that chronic eczematous dermatitis in patients with neurodegenerative diseases may be an early marker of bullous pemphigoid.', 'By conducting retrospective chart review, we found neurodegenerative diseases are more prevalent in elderly patients with chronic eczematous dermatitis.', 'The mean time delay between the diagnosis of neurodegenerative diseases and onset of skin lesions is 4.17years.', 'Together with the well-known association between bullous pemphigoid and neurodegenerative diseases, the results suggested that unlocalized eczematous dermatitis in the elderly may be an early manifestation of bullous pemphigoid.', 'Inter-discipline communication among neurology, dermatology and geriatrics/gerontology is required to tailor specific managements for elderly patients with pruritus and neurodegenerative diseases.'], ['Cognitive reserve (CR) and brain reserve (BR) are protective factors against age-associated cognitive decline and neurodegenerative disorders.'], ["Parkinson's disease (PD) is the second most common neurodegenerative disorder after Alzheimer's disease."], ["BACKGROUND: Parkinson's disease (PD) is the second most common neurodegenerative disease in the elderly."], ['Altered cortical thickness has been observed in aging and various neurodegenerative disorders.'], ['OBJECTIVE: Age-related cognitive impairment and the prevalence of neurodegenerative disease contribute to decreasing quality of life in affected individuals and their families as well as demand considerable societal responsibility.'], ['Our objective was to examine whether abnormalities in neuroimaging measures of amyloid and neurodegeneration are correlated with odor identification (OI) in the population-based Mayo Clinic Study of Aging.'], ['Importantly, accumulating knowledge on the metabolic control of neurogenesis provides a theoretical framework for the trial of new or repurposed drugs capable of interfering with nutrient sensing as enhancers of neurogenesis in the context of neurodegeneration and brain senescence.'], ['Risk of olfactory dysfunction increases with old age and may also result from chronic sinonasal diseases, severe head trauma, and upper respiratory infections, or neurodegenerative diseases.'], ['Chronic and degenerative diseases are the main causes of death in the aging population worldwide.', 'Cell therapy that involves the injection of viable cell into patients is a promising therapeutic strategy in chronic and degenerative diseases.'], ['It has been widely accepted as an anti-tumor program and is also found closely related to embryo development, tissue repair, organismal aging and age-related degenerative diseases.'], ['Aging is the most prominent risk factor triggering several degenerative diseases, such as osteoarthritis (OA).'], ['However, despite these differences, human and mouse microglia also show similarities in morphology and behaviour, such that the mouse is a suitable model for studying the role of microglia, as long as these differences are taken into consideration when delineating new strategies to approach the study of neurodegenerative diseases.'], ['These include non-alcoholic fatty liver disease, hypertension, neurodegenerative diseases, sarcopenia and osteoporosis.'], ["Alzheimer's disease (AD), the main form of dementia in the elderly, is the most common progressive neurodegenerative disease characterized by rapidly progressive cognitive dysfunction and behavior impairment."], ['Context: Accumulation of brain iron is linked to aging and protein-misfolding neurodegenerative diseases.', 'Objective: The aim of this systematic review was to examine evidence from animal and human studies of the effects of high iron intake or peripheral iron status on adult cognition, brain aging, and neurodegeneration.', 'Neurodegenerative disease diagnosis and/or behavioral/cognitive, biochemical, and brain morphologic findings were used to study the effects of iron intake or peripheral iron status on brain health.', 'Conclusions: Human studies are needed to verify whether dietary iron intake levels used in neonates/infants to prevent iron deficiency have effects on brain aging and neurodegenerative disease outcomes.'], ['The aim of this stereological study of 10 structures and 5 subdivisions with and without neurofibrillary degeneration in the brains of 28 individuals 25-102-years-old was to establish the pattern of age-associated neurodegeneration and neuronal loss in the brains of nondemented adults and elderly.'], ['Importance: Gait performance is affected by neurodegeneration in aging and has the potential to be used as a clinical marker for progression from mild cognitive impairment (MCI) to dementia.'], ['Protein misfolding is linked to a rapidly expanding list of human diseases, ranging from neurodegenerative diseases to aging and cancer.'], ['Increased rate of cancers, neurodegenerative disorders, reproductive dysfunction, birth defects, respiratory diseases, cardiovascular diseases and aging have been linked with insecticide exposure.'], ["Understanding why Alzheimer's disease fails to develop in species that are biologically proximal to humans could disclose new therapeutic targets in the chain of events leading to neurodegeneration and dementia."], ["Other Neurological degenerative diseases with potential nutritional components such as Parkinson's disease, frailty of age and Multiple Sclerosis, a disease with increased activity from vitamin D deficiency, may also be related to untreated exocrine pancreatic insufficiency causing impaired absorption of essential dietary elements.", 'Testing of patients with Neurological degenerative diseases for EPI may enable correction of underlying nutritional deficiencies with enzyme replacement as necessary, possibly resulting in improvement of the underlying Neurological condition.'], ['These responses play an important role in carcinogenesis, neurodegeneration, and aging.'], ['Cerebrovascular disease and neurodegenerative causes of cognitive impairment may become more common with advancing age; how these factors interact with HIV-associated cognitive impairment is not yet known.Cerebrospinal fluid HIV RNA escape may occur in up to 10% of patients undergoing lumbar puncture clinically and can be associated with compartmentalized and resistant virus.Changes in antiretroviral therapy in patients with cognitive impairment should be based on current and historic resistance profiles of cerebrospinal fluid and plasma virus, or on potential antiretroviral drug neurotoxicity.'], ['There is substantial interest in using EVs as biomarkers for age-related diseases including cancer, and neurodegenerative, metabolic and cardiovascular diseases.'], ["INTRODUCTION: Alzheimer's disease (AD) is a primary and progressive neurodegenerative disorder, which is marked by cognitive deterioration and memory impairment."], ['OM typically affects the elderly and is often associated with neurodegenerative disease.'], ["BACKGROUND: A new classification for biomarkers in Alzheimer's disease and cognitive ageing research is based on grouping the markers into three categories: amyloid deposition (A), tauopathy (T), and neurodegeneration or neuronal injury (N).", 'Participants were classified as having normal (A-) or abnormal (A+) amyloid using amyloid PET, normal (T-) or abnormal (T+) tau using tau PET, and normal (N-) or abnormal (N+) neurodegeneration or neuronal injury using cortical thickness assessed by MRI.', "Tau PET and neurodegeneration biomarkers were discordant in most individuals who would be categorised as stage 2 or 3 preclinical Alzheimer's disease (A+T+N-, A+T-N+, and A+T+N+; 86% at age 65 years and 51% at age 80 years) or with suspected non-Alzheimer's pathophysiology (A-T+N-, A-T-N+, and A-T+N+; 92% at age 65 years and 78% at age 80 years).", 'INTERPRETATION: Biomarkers of fibrillar tau deposition can be included with those of beta-amyloidosis and neurodegeneration or neuronal injury to more fully characterise the heterogeneous pathological profiles in the population.'], ["Factors influencing the measurement and interpretation of these clinical findings are then discussed, including reproducibility, the influence of comorbidities, secular trends, how 'normality' should best be defined, the problems of extrapolating group data to individuals and the influence of presymptomatic neurodegenerative disease states."], ['Autophagy, a catabolic process necessary for the maintenance of intracellular homeostasis, has recently been the focus of numerous human diseases and conditions, such as aging, cancer, development, immunity, longevity, and neurodegeneration.', 'However, the continued presence of autophagy is essential for cell survival and dysfunctional autophagy is thought to speed up the progression of neurodegeneration.', "Physiologically, neurodegenerative disorders are related to the accumulation of amyloid beta peptide and alpha-synuclein protein aggregation, as seen in patients with Alzheimer's disease and Parkinson's disease, respectively.", 'Even though autophagy could impact several facets of human biology and disease, it generally functions as a clearance for toxic proteins in the brain, which contributes novel insight into the pathophysiological understanding of neurodegenerative disorders.', 'Therefore, this review briefly deliberates on the recent implications of autophagy in neurodegenerative disorder control, and emphasizes the opportunities and potential therapeutic application of applied autophagy.'], ['AIMS: While vascular pathology is a common feature of a range of neurodegenerative diseases, we hypothesized that vascular changes occur in association with normal ageing.'], ['Taken together, our findings demonstrate APOE genotype-dependent effects using human iPSC-derived astrocytes and provide novel evidence that the human iPSC-based model system is a strong tool to explore how apoE isoforms contribute to neurodegenerative diseases.'], ['Methods: Odor identification performance and self-reported olfactory functioning were studied in 2,234 people aged 60-90 years, who were free of neurodegenerative disease and enrolled in the Swedish National Study on Aging and Care in Kungsholmen (SNAC-K) study, Stockholm, Sweden.'], ['OBJECTIVES: To evaluate the association between the Mediterranean diet (MedDiet) and the Mediterranean-DASH diet Intervention for Neurodegeneration Delay (MIND diet) and cognition in a nationally representative population of older U.S. adults.'], ['Collectively, these findings support the use of SnCs as a therapeutic target for treating degenerative joint disease.'], ['NAF-1 and mNT are also implicated in a number of other human pathologies including diabetes, neurodegeneration and cardiovascular disease, as well as in development, differentiation and aging.'], ["Despite the frequent occurrence of olfactory changes at the early stages of neurodegenerative disorders such as Alzheimer's disease, olfactory disorders are rarely assessed in daily clinical practice, mainly due to a lack of standardised assessment tools.", 'The aims of this review were to (1) summarise the existing literature on olfactory disorders in ageing populations and patients with neurodegenerative disorders; (2) present the strengths and weaknesses of current olfactory disorder assessment tools; and (3) discuss the benefits of developing specific olfactory tests for neurodegenerative diseases.', 'CONCLUSION: Otolaryngologists are encouraged to use olfactory tests in older adults to help predict the development of neurodegenerative diseases.'], ["Drug repurposing has been recognized as being equally as promising as de novo drug discovery in the field of neurodegeneration and Parkinson's disease specifically."], ['Importance: While amyloid and neurodegeneration are viewed together as Alzheimer disease pathophysiology (ADP), the factors that influence amyloid and AD-pattern neurodegeneration may be considerably different.', 'Objective: To identify the combined and independent protective factors for amyloid and AD-pattern neurodegeneration in a population-based sample and to test the hypothesis that "exceptional agers" with advanced ages do not have significant ADP because they have protective factors for amyloid and neurodegeneration.'], ["But to the best of the authors' knowledge, researchers so far have investigated the structural complexity only in the context of two restricted networks known as Small-World and Scale-free networks; whereas other aspects of the structural complexity of brain activities may be affected by aging and neurodegenerative disorders such as the Alzheimer's disease and autism spectrum disorder."], [': (1) improvement in cognitive testing; (2) delaying or preventing age-related deterioration of cognitive decline; (3) reducing the risk of neurodegenerative diseases.'], ["Age-related brain atrophy is a common finding, but neurodegenerative diseases such as Alzheimer's disease are associated with accelerated atrophy of the medial temporal lobe."], ['The increasing proportion of people over the age of 65 could lead to a higher incidence of chronic-degenerative diseases and a greater demand for health and social care with a consequent impact on health spending.'], ['Consistent with the ETH, the LCRs score high for developing disease risks, including metabolic syndrome, neurodegeneration, cognitive impairment, fatty liver disease, susceptibility to cancer, and reduced longevity.'], ['Reliable tracking of memory requires assessment instruments that are stable over time to better understand changes potentially attributable to neurodegenerative disease.'], ["The role of monocytes and macrophages in the pathogenesis of neurodegenerative disorders such as Alzheimer's disease (AD) is poorly understood."], ["Onset of neurodegenerative disorders, including Huntington's disease, is strongly influenced by aging."], ['INTRODUCTION: Misfolded tau and amyloid beta (Abeta) proteins progressively accumulate in the human brain, causing altered neuronal function and neurodegeneration.'], ['Moreover, the brains of these mice show increased signs of DNA damage, cell death, and hyperphosphorylated Tau-a critical mark in several neurodegenerative diseases.', "Therefore, SIRT6 and its downstream signaling could be targeted in Alzheimer's disease and age-related neurodegeneration."], ["Alzheimer's disease and Parkinson's disease are two common neurodegenerative diseases of the elderly people that have devastating effects in terms of morbidity and mortality."], ['The immunoregulatory human leukocyte antigen (HLA) complex has been linked to susceptibility for a number of neurodegenerative diseases, including AD; however, studies to date have failed to consistently identify a risk HLA haplotype for AD.'], ['Human insulin is a pivotal protein hormone controlling metabolism, growth, and aging and whose malfunctioning underlies diabetes, some cancers, and neurodegeneration.'], ['OBJECTIVE: To disentangle the contribution of motor impairment and extra-motor manifestations to QoL in subjects with MPS (n=63), manifest PD (n=69), disorders with motor symptoms due to non-neurodegenerative diseases (n=213) and healthy controls (n=258).'], ['Accumulation of DNA damage in the first 1000 days may increase risk of accelerated ageing and degenerative diseases in adult life such as cancers.'], ["A variety of Drosophila mutant lines have been established as potential disease-models to study various disease mechanisms including human neurodegenerative diseases like Alzheimer's disease (AD), Huntington's disease (HD) and Parkinson's disease (PD).", 'Therefore, it is suggested that APPL-knockdown approach can be used as an alternative approach to study neurodegenerative diseases in the fly model.'], ['The development of these functional olive oils may help in prevention of chronic diseases (such as cardiovascular diseases, immune frailty, ageing disorders and degenerative diseases) and improving the quality of life for many consumers reducing health care costs.'], ["Alzheimer's disease (AD) is a degenerative brain disease and the most common cause of dementia."], ["The pathology's effects increase cerebral damage, leading to the rapid onset of neurodegenerative diseases.", 'This review focuses three aspects: the clinical manifestation of diabetes regarding glial and neuronal cells, the association between neurodegeneration and diabetes and summarises some of the pharmacogenomic data obtained from studies of T2DM treatment, focusing on polymorphisms in genes affecting pharmacokinetics, pharmacodynamics and treatment outcome of the most commonly-prescribed oral anti-diabetic drugs (OADs).'], ['Increasing age is the most significant risk factor for neurodegenerative diseases associated with amyloid plaques.', 'To date, nearly three dozen different misfolded proteins targeting brain and other organs have been identified in amyloid diseases and AD, the most prevalent neurodegenerative amyloid disease affecting over 15 million people worldwide.'], ["Membrane lipid composition is altered in the brain during the pathogenesis of several age-related neurodegenerative diseases, including Alzheimer's disease."], ['Further, these data suggest that companion dogs may be a particularly useful animal model for understanding mechanisms of age-related degenerative valve disease and for developing and testing interventions to ameliorate cardiac disease.'], ["Alzheimer's disease (AD) is a chronic, progressive and prevalent neurodegenerative disease characterized by the loss of higher cognitive functions and an associated loss of memory."], ["Neuroinflammation characterized by activation of glial cells is observed in various neurodegenerative diseases including Alzheimer's disease (AD).", 'These findings suggest a novel mechanism of neuroinflammation that may explain prolonged progression of AD and help us to explore preventive and therapeutic strategies to treat neurodegenerative diseases.SIGNIFICANCE STATEMENT Ether-type glycerophospholipids, plasmalogens (Pls), are reduced in the brain of Alzheimer disease (AD) patients.', 'Our findings provide a new insight into the mechanism of neuroinflammation and may help to develop a novel therapeutic approach for neurodegenerative diseases such as AD.'], ["BACKGROUND: Alzheimer's disease (AD) is the most common neurodegenerative dementia of old age, and the leading chronic disease contributor to disability and dependence among older people worldwide."], ["CONCLUSION: These findings highlight the importance of considering sex differences in the interpretation of cognitive data which contribute to clinical diagnosis of neurodegenerative disorders, such as Alzheimer's disease."], ['New lines of evidence suggest that less than 10% of neurodegenerative diseases have a strict genetic aetiology and other factors may be prevalent.'], ['Brain connectivity has been assessed in several neurodegenerative disorders investigating the mutual correlations between predetermined regions or nodes.'], ['Hyperglycemia is a cause of cognitive deterioration, low intelligent quotient, neurodegeneration, brain aging, brain atrophy and dementia.', "It seems that the pathogenesis of hyperglycemia-induced brain injury is complex and includes combination of vascular disease, oxidative stress, neuroinflammation, mitochondrial dysfunction, apoptosis, reduction of neurotrophic factors, acetylcholinesterase (AChE) activation, neurotransmitters' changes, impairment of brain repair processes, impairment of brain glymphatic system, accumulation of amyloid beta and tau phosphorylation and neurodegeneration."], ['While the neurodegeneration and symptomology of PD develop chronically over the years, post-stroke neuronal death and dysfunction develop rapidly in days.'], ['In addition, the acquired insight could be relevant for vestibular patients, patients with neurodegenerative disorders, as well as the elderly population, coping with multisensory deficit syndromes, immobilization, and inactivity.'], ["Oxidative stress and synapse dysfunction are the major neurodegenerative damage correlated to cognitive impairment in Alzheimer's disease (AD).", 'These observations strongly suggest that propolis protects from the neurodegenerative damage in neurons through the properties of various antioxidants.'], ['Methyl glyoxal (MG), a major precursor of advanced glycation end-products, has been identified as significant in the progression of several diseases including aging, diabetes and neurodegenerative diseases as well as causing hepatic damages.'], ['Previously, the contribution of peripheral infection to cognitive decline was largely overlooked however, the past 15 years have established a key role for infectious pathogens in the progression of age-related neurodegeneration.'], ["Parkinson's disease (PD) is a progressive neurodegenerative disorder of the basal ganglia."], ['Phosphodiesterase 10A enzyme (PDE10A) is an important striatal target that has been shown to be affected in patients with neurodegenerative disorders, particularly Huntington s disease (HD).'], ["Mitochondrial and bioenergetic changes are also documented in various age-related neurodegenerative diseases, including Alzheimer's disease (AD).", 'Mitochondrial and bioenergetic dysfunction could, therefore, link neurodegeneration to brain aging.'], ["Most common aging-associated diseases are cardiovascular disease, cancer, arthritis, dementia, cataract, osteoporosis, diabetes, hypertension, and neurodegenerative diseases such as Alzheimer's disease, Huntington's disease, Parkinson's disease, and amyotrophic lateral sclerosis."], ["Alzheimer's disease (AD) is characterized by cognitive dysfunction and progressive neurodegeneration."], ["Aberrant DNA methylation has been observed in the patients with Alzheimer's disease (AD), a common neurodegenerative disorder in the elderly."], ["Mitochondrial dysfunction and DNA damage is intimately connected to ageing and neurodegeneration, including Alzheimer's disease (AD).", 'Defects in BER have been detected in ageing and neurodegeneration.'], ['Loss of proteostasis underlies ageing and neurodegeneration characterized by the accumulation of protein aggregates and mitochondrial dysfunction.', 'Although many neurodegenerative-disease-associated proteins can be found in mitochondria, it remains unclear how mitochondrial dysfunction and protein aggregation could be related.'], ["The aging of the human population is resulting in an increase in the number of people afflicted by neurodegenerative disorders such as Parkinson's disease (PD), creating tremendous socio-economic challenges."], ['CONCLUSIONS: Prolonged sleep duration may be a marker of early neurodegeneration and hence a useful clinical tool to identify those at a higher risk of progressing to clinical dementia within 10 years.'], ['We evaluated if the associations of urine albumin creatinine ratio (ACR) with all-cause and CVD mortality differed depending on serum concentrations of persistent organic pollutants (POPs), strong lipophilic chemical mixtures with very long half-lives, which are recently linked to many degenerative diseases.'], ['Tauopathies include a variety of neurodegenerative diseases associated with the pathological aggregation of hyperphosphorylated tau, resulting in progressive cognitive decline and motor impairment.'], ['However, an accelerated aging effect was not demonstrated, which may suggest that the FA measurements used are not sufficiently sensitive or, alternatively, age-related white matter neurodegeneration is not obvious prior to overt clinical dementia.'], ['The rationale for this approach, as indicated in this report, is supported by growing evidence that neurodegenerative damage and cognitive impairment during advanced aging is accelerated or triggered by a neuronal energy crisis generated by brain hypoperfusion.'], ['Disruption of mitochondria axonal transport, essential for the maintenance of synaptic and neuronal integrity and function, has been identified in neurodegenerative diseases.'], ['This neurodegenerative disease becomes more prevalent with aging, but predisposing genetic and environmental factors also contribute to increased risk.'], ['They are involved in the regulation of iron and reactive oxygen metabolism, and have been associated with the progression of diabetes, cancer, aging and neurodegenerative diseases.'], ["TD induces selective neuronal cell death, neuroinflammation, endoplasmic reticulum (ER) stress and oxidative stress in the brain which are commonly observed in many aging-related neurodegenerative diseases, such as Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD) and progressive supranuclear palsy (PSP).", 'In this study, we for the first time used human induced pluripotent stem cells (hiPSCs)-derived neurons (iCell neurons) to investigate the mechanisms of TD-induced neurodegeneration.', 'It establishes that the iCell neurons are a novel tool to investigate cellular and molecular mechanisms for TD-induced neurodegeneration.'], ['The incidence of neurodegenerative diseases in the developed world has risen over the last century, concomitant with an increase in average human lifespan.', 'A major challenge is therefore to identify genes that control neuronal health and viability with a view to enhancing neuronal health during ageing and reducing the burden of neurodegeneration.', 'These genes are thus novel candidates for a role in neurological health and disease and could now be further investigated to confirm their function and regulation during ageing and neurodegeneration.'], ['We propose that the dysregulation of mitochondrial dynamics leads to age-induced accumulation of unhealthy mitochondria and contributes to alterations linked to aging, such as diabetes and neurodegeneration.'], ["OBJECTIVE: Allele-dependent differences in this pattern of functional connectivity were investigated in patients with very mild neurodegeneration of the Alzheimer's type, carriers and non-carriers of the epsilon4 allele.", 'These differences indicate that the epsilon4 allele is associated with a more profound degree of DMN network breakdown even in the prodromal stage of neurodegeneration.'], ['This provides health professionals with valuable information of neurodegeneration stages, and a potential to provide a better understanding of disease pathology.'], ['Our observations support the view that primary oligodendroglial abnormalities can evoke pathogenically relevant neuroinflammation that drives neurodegeneration, as observed in some forms of multiple sclerosis but also in other, genetically-mediated neurodegenerative disorders of the human nervous system.'], ['Genomic instability is a hallmark of cancer and a common feature of human disorders, characterized by growth defects, neurodegeneration, cancer predisposition, and aging.'], ['Self-association of amyloidogenic proteins is the main pathological trigger in a wide variety of neurodegenerative disorders.'], ['Brain aging is accompanied by increased oxidative stress and what has been termed "neuroinflammation," which might contribute to age-related neurodegenerative diseases.', 'Moreover, gene expression of major anti-oxidative stress responses did not match neuroinflammation in aging or increased regional susceptibility to major neurodegenerative diseases.'], ['Genotoxins are involved in the pathogenesis of several chronic degenerative diseases including hepatic, neurodegenerative and cardiovascular disorders, diabetes, arthritis, cancer, chronic inflammation and ageing.'], ['BACKGROUND: In the aging society, there is a growing number of patients with advanced degenerative disease of the spine.', 'This paper aims to analyse the reasons for failure of surgery for degenerative disease of the lumbar spine.', 'MATERIAL AND METHODS: Histories of patients operated on by one group of surgeons in the Neuroorthopaedic Department of "STOCER" in 2014 and 2015 due to degenerative disease of the lumbar spine were analysed retrospectively.'], ['Montreal cognitive assessment (MoCA) is a test providing a brief screening for people with cognitive impairment due to aging or neurodegenerative syndromes.'], ['Mitochondria play a key role in common neurodegenerative diseases and contain their own genome: mtDNA.', 'Common inherited polymorphic variants of mtDNA have been associated with several neurodegenerative diseases, and somatic deletions of mtDNA have been found in affected brain regions.', 'However, there are conflicting reports describing the role of rare inherited variants and somatic point mutations in neurodegenerative disorders, and recent evidence also implicates mtDNA levels.', 'Based on these findings, single nucleotide variants of mtDNA are unlikely to play a major role in the pathogenesis of these neurodegenerative diseases, but mtDNA levels merit further investigation.'], ['Formation of these protein aggregates leads to AD-like neurodegeneration.'], ['Lipid peroxidation is involved in many disorders and diseases such as cardiovascular disease, cancers, neurodegenerative diseases, and even aging.'], ['The present study corroborates and provides a mechanism to the hypothesis that suggests metal-mediated oxidation of catecholamines contributes to the pathogenesis of neurodegenerative diseases.'], ['CMRGlu has been used as a biomarker of brain aging and neurodegenerative diseases, but the complexity and invasive nature of PET often limits its use in research.'], ['BACKGROUND: Vitamin D plays a role in protecting against chronic degenerative diseases.'], ['Mutations resulting in haploinsufficiency of progranulin (PGRN) cause frontotemporal lobar degeneration with TDP-43-positive inclusions (FTLD-TDP), a devastating neurodegenerative disease.'], ["BACKGROUND: Alzheimer's and Parkinson's disease represent the two most common neurodegenerative disorders, affecting an increasing number of patients worldwide.", "Finally, given the importance of non-coding RNAs in neurodegeneration, their contribution to Alzheimer's and Parkinson's disease will be examined, together with a brief summary of the available miRNA-based biomarker signatures for these two conditions."], ['Genome instability has long been implicated as a salient causal factor in aging and age-related diseases such as cancer and neurodegeneration.'], ["BACKGROUND: Parkinson's disease is the second most common neurodegenerative disorder for which old age is the best known risk.", 'Several other neurodegenerative disorders also produce Parkinson syndrome.'], ['Chorea-Acanthocytosis is a rare, neurodegenerative disorder characterized by progressive loss of locomotor and cognitive function.', 'Vps13 mutant flies showed a shortened life span and age associated neurodegeneration.'], ['We evaluated the efficacy of sunitinib to promote autophagy in the CNS and ameliorate neurodegeneration using LC3-GFP-expressing neuronal cells challenged with low concentrations of Tat and using inducible Tat transgenic mice.', 'Restoration of CDK5 and autophagy were associated with reduced neurodegeneration and behavioral alterations.', 'We conclude that sunitinib might ameliorate Tat-mediated autophagy alterations and may decrease neurodegeneration in aging patients with HAND.'], ['RECENT FINDINGS: We briefly summarize new research and highlight a recent study designed to prospectively identify agrochemicals with the potential to induce neurological diseases and place these discoveries into the already rich neurodegeneration and aging literature.'], ['This age-associated shift in lineage potential is associated with decreased cellular immunity and increased incidence of diseases with prominent inflammatory components including atherosclerosis, autoimmunity, neurodegenerative disease, and carcinogenesis.'], ["Degenerative diseases of the human brain continue to pose one of biomedicine's most intractable problems.", 'Research on human neurodegeneration is now moving from descriptive to mechanistic analyses.', 'We now appreciate that mild cognitive impairment in early AD may be due to synaptic dysfunction caused by accumulation of non-fibrillar, oligomeric Abeta, occurring well in advance of evident widespread synaptic loss and neurodegeneration.', 'This article aims to present a critical overview of current knowledge on the bases of synaptic dysfunction in neurodegenerative diseases, with a focus on AD, and will cover amyloid- and nonamyloid- driven mechanisms.'], ['Aging is a complex phenomenon and its impact is becoming more relevant due to the rising life expectancy and because aging itself is the basis for the development of age-related diseases such as cancer, neurodegenerative diseases and type 2 diabetes.'], ['Interestingly, the 11-gene signature that we identified may represent a cluster of immune and regulatory genes that are deregulated in the hippocampus and possibly other brain regions during aging as well as in some neurodegenerative diseases and low-grade brain tumors.'], ['Prior studies also suggest enrichment of protein-bound 2-AAA as an oxidative post-translational modification of lysyl residues in tissues associated with degenerative diseases of aging.'], ['Although described in a subset of pediatric disorders, new genomic technologies have detected higher than anticipated frequencies of clonal mosaicism in adult population studies, stimulating investigation as to how clonal mosaicism could contribute to chronic human diseases, such as cancer, diabetes and neurodegenerative disorders.'], ['Furthermore, mitochondria and their metabolism have been implicated in aging and several human diseases, including inherited mitochondrial disorders, cardiac dysfunction, heart failure, neurodegenerative diseases, diabetes, and cancer.'], ['Emerging studies suggest that peroxisomal function may also be altered with aging and contribute to the pathogenesis of a variety of diseases, including diabetes and its related complications, neurodegenerative disorders, and cancer.'], ['Rare pleiotropic genetic disorders, Ataxia-telangiectasia (A-T), Bloom syndrome (BS) and Nijmegen breakage syndrome (NBS) are characterised by immunodeficiency, extreme radiosensitivity, higher cancer susceptibility, premature aging, neurodegeneration and insulin resistance.'], ["Progressive neurodegenerative diseases like Alzheimer's disease (AD) or Parkinson's disease (PD) are an increasing threat to human health worldwide.", 'Besides behavioral deficits, neurodegenerative diseases are characterized by histological phenotypes such as neuronal death and axonopathy.', 'Neurodegeneration is then assessed by measuring the size and/or number of vacuoles that have developed in the fly brain.'], ["Alzheimer's disease (AD) is a devastating neurodegenerative disorder without a cure.", 'Oxidative stress has been recognized as a contributing factor in aging and in the progression of multiple neurodegenerative diseases including AD.'], ['This effort can only be enabled by a deep quantitative understanding of the contribution of these factors to neurodegenerative disease, both individually and in combination.'], ['Patients presenting with osseointegrated implants with their respective prostheses installed were included, and they could be carriers of chronic and degenerative diseases, such as diabetes, osteoporosis, hypothyroidism, cardiovascular disease (CVD), and systemic arterial hypertension.'], ["Neurogenic orthostatic hypotension (nOH) is common in patients with neurodegenerative disorders such as Parkinson's disease, multiple system atrophy, pure autonomic failure, dementia with Lewy bodies, and peripheral neuropathies including amyloid or diabetic neuropathy."], ['Dysphagia is commonly associated with the outcomes of neurodegenerative diseases such as SCA6.'], ['Osteoporosis is known as a degenerative disease of the skeletal system and its main complication is fracture, which influences quality of life in the elderly.'], ['Aging is identified by a progressive decline of physiological integrity leading to age-related degenerative diseases, but its causes is unclear.'], ['METHOD: To answer this question we analysed age-related variations in the fractal dimension of a large corpus of digital images (n = 2092) of work created by seven notable artists who experienced both normal ageing and neurodegenerative disorders.', 'RESULTS: The results of our analysis showed that patterns of change in the fractal dimension of the paintings differentiated artists who suffered neurological deterioration from those of normal aging controls.', "Secondly, our work suggests that may be possible to identify a-typical changes in the structure of an artist's work; changes that may be early indicators of the onset of neurological deterioration."], ['AGEs are therefore accepted biomarkers for aging, diabetes, and several degenerative diseases.'], ['Areas covered: This narrative review discusses use of monoamine oxidase inhibitors in the context with chronic neurodegeneration.', 'In patients with chronic neurodegenerative disorders, symptoms, such as depression and apathy, are often treated with drugs that elevate biogenic amine levels.', 'This therapeutic strategy increases biogenic amine turnover, thereby generating neurotoxic aldehydes and enhanced oxidative stress, each of which influence and accelerate the course of neurodegeneration.'], ['The enzyme TDO (tryptophan 2,3-dioxygenase; TDO-2 in Caenorhabditis elegans) is a potential therapeutic target to cancer but is also thought to regulate proteotoxic events seen in the progression of neurodegenerative diseases.'], ['Erythrocyte adaptation to a short-term oxidative stress may serve as a basis for future studies about the impact of more prolonged oxidative events, often associated to aging, drug consumption, chronic alcoholism, hyperglycemia, or neurodegenerative diseases.'], ['Longitudinal observations to assess their potential independent or synergistic, sequential or parallel effects on cognition, disease progression, and other disease-specific biomarkers of neurodegeneration would be required to further clarify the respective role of Alphabeta and tau deposition play in the course of AD.'], ['Dysregulation has been linked to the development of various human diseases, including neurodegeneration and tumorigenesis, infection, and aging.'], ["Human brain aging is the physiological process which underlies as cause of cognitive decline in the elderly and the main risk factor for neurodegenerative diseases such as Alzheimer's disease."], ['We also make an inventory of knowledge about the effects of age and neurodegenerative diseases on social cognition.'], ['Although first discovered and reported as a receptor for advanced glycation end products (AGEs), the expansion of the repertoire of RAGE ligands implicates the receptor in diverse milieus, such as autoimmunity, chronic inflammation, obesity, diabetes, and neurodegeneration.'], ['BACKGROUND: Low-abundance mutations in mitochondrial populations (mutations with minor allele frequency <= 1%), are associated with cancer, aging, and neurodegenerative disorders.'], ['They are thought to contribute to cancer, aging, and neurodegenerative diseases.'], ['Primary and secondary study outcomes were poor functional outcome (modified Rankin Scale 3-6) at 3 months after the stroke onset and neurological deterioration (>=2-point increases on the National Institutes of Health Stroke Scale score during hospitalization), respectively.', 'The frequencies of neurological deterioration and poor functional outcome were significantly higher in patients with pre-stroke dementia than in those without pre-stroke dementia (neurological deterioration, 16.1 vs. 7.1%, p < 0.01; poor functional outcome, 63.7 vs. 27.1%, p < 0.01).', 'Multivariable analysis showed that pre-stroke dementia was significantly associated with neurological deterioration (OR 1.67; 95% CI 1.14-2.41; p < 0.01) and poor functional outcome (OR 2.91; 95% CI 2.17-3.91; p < 0.01).', 'CONCLUSIONS: Pre-stroke dementia was significantly associated with higher risks for poor functional outcome at 3 months after stroke onset as well as for neurological deterioration during hospitalization in patients with acute ischemic stroke.'], ["Parkinson's disease is an age-associated progressive neurodegenerative disorder that has gained crescent social and economic impact due to the aging of the western society."], ['However, the transgenic mice exhibited poor memory, depressive-like behavior, severely decreased dendrites in the hippocampal CA3 region and medial prefrontal cortex indicative of neurodegeneration, hyperphosphorylation of tau at Ser396, and diminished neurogenesis in the dentate gyrus at 50 weeks old.'], ['BACKGROUND: The mechanisms of neurologic deterioration (ND) are not fully understood.', 'The aim of the present study was to evaluate the relationship between CYP genetic variants and CYP metabolite levels with ND in acute ischemic stroke patients.', 'The primary outcome was ND within 10 days on admission.', 'ND was defined as an increase of two or more points in the National Institutes of Health Stroke Scale score.', 'RESULTS: Among 396 patients, 101 patients (25.5%) experienced ND.', 'The plasma levels of 20-HETE and DiHETEs were significantly higher and the EET levels were significantly lower in patients with ND compared to patients without ND.', 'Univariate analyses revealed that old age, diabetes mellitus (DM), higher fasting glucose, and higher hemoglobin A1c (HbA1c) were associated with ND.', 'CYP2C8 rs17110453 CC, EPHX2 rs751141 GG, and CYP4A11 rs9333025 GG were independently associated with ND after adjusting age, DM, fasting glucose, and HbA1c (odds ratio [OR]: 1.60, 95% confidence interval [CI]: 1.02-3.72; OR: 3.01, 95% CI: 1.29-7.13; OR: 2.75, 95% CI: 1.17-6.24, respectively).', 'Also, these polymorphisms were associated with CYP metabolite levels in patients with ND.', 'CONCLUSIONS: ND is fairly common in acute ischemic stroke.', 'Specific CYP gene SNPs are associated with CYP plasma metabolite levels, which may explain their associations with ND.'], ["We demonstrate that neurodegeneration of subcortical structures in Alzheimer's disease is not symmetric."], ['Results and interpretation - Based on the studies on treatment of degenerative lesions and early OA, there is low-level evidence to suggest that cartilage repair is a possible treatment for such lesions, but there are conflicting results regarding the effect of advanced age on the outcome.', 'We concluded that further improvements are needed for direct repair of focal, purely traumatic defects before we can routinely use such repair techniques for the more challenging degenerative lesions.'], ["Emerging findings suggest that fasting, exercise and an intellectually challenging lifestyle can protect neurons against the dysfunction and degeneration that they would otherwise suffer in acute brain injuries (stroke and head trauma) and neurodegenerative disorders including Alzheimer's, Parkinson's and Huntington's disease."], ['Other highly relevant risk factors were activities of daily living (ADL), instrumental ADL, aging, depression, gender, the APOE epsilon4 allele, and comorbidities (depression as well as gastrointestinal, osteoarticular, and neurodegenerative diseases).'], ['We focused analysis on genetic modifiers in pathways related to lipid metabolism, longevity, and neurodegenerative disease.'], ["Parkinson's disease (PD), the second most common progressive neurodegenerative disorder of aging, was long believed to be a non-genetic sporadic origin syndrome."], ['Deformities caused by degeneration represented 67% of the pathology in patients aged over 65 years; however, non-degenerative disease such as adult idiopathic scoliosis and syndromic or congenital deformity represented over 60% of pathology in patients aged less than 65 years.'], ['Aging-associated dysfunction of microglia comprises phenotypes resembling cellular senescence, which could contribute to cognitive impairments observed in various neurodegenerative diseases.'], ['BACKGROUND: Alterations of the sleep-wake cycle are common features of neurodegenerative dementia.'], ['We set forth to determine the cost utility following anterior cervical decompression and fusion (ACDF) for degenerative disease in older patients.', 'METHODS: Patients undergoing ACDF for degenerative diseases were enrolled into prospective longitudinal registry.'], ['The human sense of smell decreases with age, and a poor sense of smell are among the most important prodromal symptoms of several neurodegenerative diseases.', 'While these findings need independent confirmation, they may lead to novel insights into the biology of the sense of smell in older adults and its relationships to neuropsychological and neurodegenerative diseases.'], ['Aging, a complex process associated with various structural, functional and metabolic changes in the brain, is an important risk factor for neurodegenerative diseases and stroke.', 'In addition to gray matter dysfunction, the plasticity and repair capacity of white matter also decrease with aging and contribute to neurodegenerative diseases.', 'Here, we review the common pathophysiological changes, treatments, and the promises and limitations of stem cell therapies in age-related neurodegenerative diseases and stroke.'], ['Increased somatic mitochondrial DNA (mtDNA) mutagenesis causes premature aging in mice, and mtDNA damage accumulates in the human brain with aging and neurodegenerative disorders such as Parkinson disease (PD).'], ['In secondary analyses, we additionally adjusted for neurodegeneration (hippocampal volume, FDG PET SUVR, and cortical thickness) in AD-associated regions.', 'RESULTS: In fully adjusted models including neuroimaging measures of neurodegeneration, higher PiB-PET SUVR across all ROIs was associated with slower gait speed (P < .05 except for the parietal ROI), lower cadence and longer double support time (P <= .05 except for the motor ROI), and greater stance time variability (P < .05).', 'CONCLUSION: PiB-PET SUVR across ROIs, independent of general measures of AD-associated neurodegeneration, is associated with poorer performance on multiple gait parameters among cognitively normal women, aged 50 to 69 years.'], ['These findings may contribute to a better understanding of olfaction and specific cognitive domains known to be affected by aging and implicated in neurodegenerative disease.'], ['In addition, aged WM becomes more susceptible to neurological disorders, such as stroke, traumatic brain injury (TBI), and neurodegeneration.'], ['Multiple sclerosis (MS) is a chronic inflammatory demyelinating disorder of the central nervous system wherein, after an initial phase of transient neurological defects, slow neurological deterioration due to progressive neuronal loss ensues.', 'Over the past years, several mechanisms have been proposed to explain the key drivers of neurodegeneration and disability accumulation in MS.', 'Several lines of evidence suggest that an interaction between MS and SVD may influence MS-related neurodegeneration.'], ['Neuroinflammation is a key event in neurodegeneration and aging, and there is mounting evidence of LRRK2 involvement in inflammatory pathways.'], ['These variations in microglial cells during ageing and in AD could reflect changes in neural-glial interactions which are emerging as key to mechanisms involved in ageing and neurodegenerative disease.'], ['OBJECTIVE With improving medical therapies for chronic conditions, elderly patients increasingly present as candidates for operative intervention for degenerative diseases of the spine.', "METHODS The 2011-2013 American College of Surgeons' National Surgical Quality Improvement Program data set was queried for patients 65 years and older with diagnosis and procedure codes inclusive of degenerative spine disease and lumbar decompression without fusion."], ['Observational evidence links low status of folate and the related B-vitamins (and/or elevated concentrations of homocysteine) with a higher risk of degenerative diseases including cardiovascular disease (CVD), cognitive dysfunction and osteoporosis.', 'Moreover, interventions with the relevant B-vitamins to optimise status may have beneficial effects in preventing degenerative diseases.'], ["Aside from cortical damage associated with age, cerebrovascular and neurodegenerative diseases, it's an outstanding question if factors of global health, including normal variation in blood markers of metabolic and systemic function, may also be associated with individual variation in brain structure."], ['Several single incretin receptor agonists that are approved for the treatment of type 2 diabetes mellitus (T2DM) have been shown to be neuroprotective in cell and animal models of neurodegeneration.', 'In the current study, the neuroprotective effects of twincretin are probed in cell and mouse models of mild traumatic brain injury (mTBI), a prevalent cause of neurodegeneration in toddlers, teenagers and the elderly.'], ['Gonarthrosis is a degenerative disease that affects mainly older people, but whose incidence has increased significantly in the last decade in population under the age of 65.'], ['Ageing, which is fundamental to neurodegeneration and dementia, affects every organ in the body and seems to be encoded partly in a blood-based signature.'], ['Abnormal mitochondrial function compromises integrated growth-related processes such as development and tissue repair, as well as homeostatic mechanisms that counteract ageing and neurodegeneration, cardiovascular disease, and cancer.'], ['The presence of large neurogenic genes, particularly in the mammalian brain and other neural tissues, further offers emerging insight into the etiology of neurodevelopmental and neurodegenerative diseases.'], ["BACKGROUND: Alzheimer's disease is a common neurodegenerative disorder in elderly."], ['Changes in Trp53 expression are associated with the main phase regulating meiotic progression with a peak in the pachytene stage, and Trp53-deficient mice exhibit degenerative syndrome (giant cells).'], ['The tri-nucleotide repeat expansion underlying Huntington disease (HD) results in corticostriatal synaptic dysfunction and subsequent neurodegeneration of striatal medium spiny neurons (MSNs).'], ['Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder characterized by damage of motor neurons.'], ['Recent studies have identified that neurodegenerative diseases are associated with the dysregulation of critical repair enzymes, as well as the misfolding, aggregation and accumulation of modified brain proteins.'], ["BACKGROUND: Alzheimer's disease (AD) is the most widespread age-related neurodegenerative disease."], ['Indeed, it appears that some accelerated aging disorders that show neurodegeneration also have mitochondrial dysfunction.'], ['Throughout the world, people are living longer, and chronic and degenerative diseases are on the rise (Bloom et al.'], ['Differential methylation has a fundamental role in the development and outcome of malignancies, chronic and degenerative diseases and aging.'], ["Given the strong association between protein aggregation, innate immune cell activation and neurodegeneration, the expression and roles of HSPs in the CNS is attracting attention in many neurodegenerative disorders including inflammatory diseases such as multiple sclerosis, protein folding diseases such as Alzheimer's disease and amyotrophic lateral sclerosis, and genetic white matter diseases.", 'Here we review the evidence linking HSPs with neurodegenerative disorders in humans and the experimental animal models of these disorders.'], ['Aging is a multifactorial process determined by molecular, cellular and systemic factors and it is well established that advancing age is a leading risk factor for several neurodegenerative diseases.', 'In fact, the close association of aging and neurodegenerative disorders has placed aging as the greatest social and economic challenge of the 21st century, and age-related diseases have also become a key priority for countries worldwide.', 'Saccharomyces cerevisiae has proven to be an unprecedented experimental model to study the fundamental aspects of aging and to decipher the intricacies of neurodegenerative disorders greatly because the molecular mechanisms underlying these processes are evolutionarily conserved from yeast to human.', 'Here we review different aging theories, common cellular pathways driving aging and neurodegenerative diseases and discuss the major contributions of yeast to the state-of-art knowledge in both research fields.'], ['Aberrant prenylation of proteins is implicated in human pathologies including cancer; neurodegenerative diseases, retinitis pigmentosa, and premature ageing syndromes.'], ["Recently, the relationship between obesity and numerous progressive and aging-related neurodegenerative diseases such as Parkinson's disease (PD) and Alzheimer's disease (AD) have been observed.", 'Thus, the involvement of the most abundant and heterogeneous group of glial cells in neurodegenerative diseases, the astrocytes, is caused by a combination of the failure on their normal homeostatic functions and the increase of toxic metabolites upon pathological event.'], ['NFL predicted neurodegeneration in older adults with very low AD probability.', 'We suggest that factors previously shown to be important for brain degeneration in mild cognitive impairment may also impact changes in normal aging, demonstrating that NFL is likely to indicate AD-independent, age-expected neurodegeneration.'], ['Here we took advantage of a well-characterized rat model that displays substantial individual differences in hippocampal memory during aging, uncontaminated by slowly progressive, spontaneous neurodegenerative disease.', 'By this approach, we aimed to interrogate the underlying neural network substrates that mediate aging as a uniquely permissive condition and the primary risk for neurodegeneration.'], ['The quest for a healthy ageing has led to the extensive study of plant polyphenols with the aim to prevent age-associated deterioration and diseases, including neurodegenerative diseases.'], ['BACKGROUND: Alzheimer s disease, a progressive and degenerative disorder of the brain, is the most common cause of dementia among the elderly.'], ["Alzheimer's disease (AD) is the most common type of progressive neurodegenerative disorder, and is responsible for the most common form of dementia in the elderly."], ['cancer, neurodegeneration, metabolic disorders).'], ['Amyloid formation is associated with a number of neurodegenerative diseases that affect the independence and quality of life of aging populations.'], ['BACKGROUND: The smell sense reduction was considered to represent the potentially warning of early stage of neurodegenerative disorders.'], ['Olive leaves and EVOO contain many phenolics effective against several aging and lifestyle-related diseases, including neurodegeneration, both in animal models and in humans.', 'The need of more clinical studies in humans to confirm the results obtained in animal and cell models to definitely support the utility of these molecules to combat or to delay the symptoms associated to aging-associated neurodegeneration is also stressed.'], ["Alzheimer's disease (AD) is a neurodegenerative disease, in which an accumulation of toxic amyloid beta in the brain precedes the emergence of clinical symptoms."], ['Over the past 20 years, stem cell technologies have become an increasingly attractive option to both study and potentially treat neurodegenerative diseases.'], ['Mutations in the Senataxin gene, SETX are known to cause the neurodegenerative disorders, ataxia with oculomotor apraxia type 2 (AOA2), and amyotrophic lateral sclerosis 4 (ALS4).'], ["Meanwhile, cognitive decline is well known to associate with ageing-related neurodegenerative diseases such as Alzheimer's disease (AD) and Parkinson's disease (PD)."], ['The presented protein-interaction network is relevant to the discoveries of the mechanisms of tumorigenesis, aging, and neurodegeneration.'], ["METHODS: This was a study of plasma tau in prospectively followed patients with AD (n = 179), patients with mild cognitive impairment (n = 195), and cognitive healthy controls (n = 189) from the Alzheimer's Disease Neuroimaging Initiative (ADNI) and cross-sectionally studied patients with AD (n = 61), mild cognitive impairment (n = 212), and subjective cognitive decline (n = 174) and controls (n = 274) from the Biomarkers for Identifying Neurodegenerative Disorders Early and Reliably (BioFINDER) study at Lund University, Sweden."], ["Electroencephalographic functional network studies in pathophysiological aging will be presented, focusing on neurodegenerative disease -such Alzheimer's disease-aiming to discuss whether network science is changing the traditional concept of brain disease and how network topology knowledge could help in modeling resilience and vulnerability of diseases."], ["Parkinson's disease (PD) is the second most common neurodegenerative disease in the elderly caused by dopaminergic neuronal cell death."], ['Common mechanisms in aging and obesity are hypothesized to increase susceptibility to neurodegeneration, however, direct evidence in support of this hypothesis is lacking.', 'This study suggests that at a population level, obesity may increase the risk of neurodegeneration.'], ["Several studies have shown a correlation between neurodegenerative diseases including Alzheimer's disease and Parkinson's disease and protein prenylation."], ['Medical history, that is medication, neurological conditions, diabetes, cardiovascular disease, chronic obstructive pulmonary disease (COPD)/asthma, dementia and mental illness, was obtained from the patient files.'], ['Accumulating reports based on animal models have indicated the importance of this catabolic program in many human pathophysiological conditions, including diabetes, neurodegenerative diseases, aging, and cancers.', 'Many patents and the research literature described in this review have shown promising applications of the relevant autophagy modulators for cancer or neurodegeneration treatments, a few of which are already being considered for clinical evaluation.'], ['These pathways are deregulated in human diseases, including cancer, neurodegeneration, metabolic disorders, muscle atrophy, ageing, and inflammation, reflecting the importance of mitophagy as a cellular housekeeping function.'], ['BACKGROUND: Due to the continuing increase of the elderly population in the western countries, the prevalence of the main chronic diseases (obesity, type 2 diabetes and related metabolic disorders, arterial hypertension, vascular damage due to atherosclerotic process, cancer, chronic obstructive pulmonary disease, neurodegenerative diseases, chronic kidney disease, immune-mediated diseases) is increasing.'], ['Answering this question would allow us to understand how the environment can shape human populations for multiple generations and may help to explain the rapid rise in obesity and neurodegenerative diseases in modern society.'], ['Treating pain in patients with advanced dementia or neurodegenerative diseases that can affect swallowing is particularly challenging because most adjuvant pain medications used to ameliorate neuropathic pain must be taken orally.'], ['BACKGROUND: Clinical studies have suggested beneficial effects of exercise on cognitive function in ageing adults and neurodegenerative diseases such as dementia.', 'Recent work indicates the same for progressive multiple sclerosis (MS), an inflammatory and degenerative disease of the central nervous system (CNS).'], ['BACKGROUND: Mild parkinsonian signs (MPS) are common in older people and are associated with an increased risk of different neurodegenerative diseases.', 'Participants underwent a detailed cognitive test battery, evaluation of prodromal markers for neurodegenerative diseases and history of vascular diseases at each study visit.'], ["Aging is the most important risk factor for human neurodegenerative diseases such as Alzheimer's and Parkinson's diseases.", 'The short lifespan and ample genetic resources of Caenorhabditis elegans (C. elegans) have made this species a favorite model organism for aging research, and the development of proteinopathy models in this organism has helped us to understand how aging processes affect protein aggregation and neurodegeneration.', 'Here, we review the recent literature on proteinopathies in C. elegans models and discuss the insights we have gained into the mechanisms of how aging processes are integrated into the pathogenesis of various neurodegenerative diseases.'], ['Alterations to myelin may be a core pathological feature of neurodegenerative diseases.'], ['Osteoarthritis is a degenerative disease of the joint affecting aging populations worldwide.'], ['INTRODUCTION: Cognitive reserve (CR) was proposed to explain how individual differences in brain function help to cope with the effects of normal aging and neurodegenerative diseases.'], ['Here, we briefly review known functions of eotaxin family members during innate immunity, and then focus on whether and how these molecules might participate in the progression of neurodegenerative diseases.'], ["The inability to effectively halt or cure Alzheimer's disease (AD), exacerbated by the recent failures of high-profile clinical trials, emphasizes the urgent need to understand the complex biochemistry of this major neurodegenerative disease."], ['Reactive oxygen species generated in mitochondria are an important factor contributing to mitochondrial and cellular dysfunction underlying many degenerative diseases, chronic pathologies and aging.'], ['Three patterns were detected as follows: the first pattern with a prevalence of 9.5% covered degenerative diseases (hearing disorder, cataract, joint disease) and cancer; The second pattern with a prevalence of 1.7% was characterized by liver disease, lung disease, gastrointestinal disease; And the third pattern with a prevalence of 22.4% was characterized by cardiovascular diseases (dyslipidaemia, hypertension, coronary heart disease), metabolic diseases (diabetes) and kidney disease.'], ['At least partially through these mechanisms, low omega-3 levels have been associated with CNS-linked disorders such as poor cognition, depression, anxiety disorders, poor anger control, attention deficit hyperactivity disorder (ADHD) and accelerated neurodegeneration in the elderly.Following a brief introduction to the history and chemistry of the omega-3 family of PUFAs, this chapter will provide an overview of the omega-3 fatty acids and how various members of this PUFA family influence central nervous system function leading towards either health or disease.'], ['A deeper understanding of the relationship between NADPH-d-positive fibers in all IC connections and their co-localization with other neurotransmitters and calcium-binding proteins will assist in better defining the function of NO in the context of its interplay with the cerebral cortex, the sequelae of the aging process and neurodegenerative disorders.'], ['Aging is a major risk factor in many forms of late-onset neurodegenerative disorders.'], ['Human corneal endothelial cells are derived from neural crest and because of postmitotic arrest lack competence to repair cell loss from trauma, aging, and degenerative disorders such as Fuchs endothelial corneal dystrophy (FECD).'], ["With its associated, elevated ROS production, the 'hyperactive' state might not cause pathology to cells that are rapidly turned over, but brain cells might accumulate long-term damage leading ultimately to neurodegeneration and the loss of mitochondrial function observed post-mortem.", "Whether the 'hyperactive' state in lymphoblasts is a biomarker specifically of PD or more generally of neurodegenerative disease remains to be determined."], ['Although the Alzheimer disease model does not recapitulate all features of the human disease, it exhibits progressive monoaminergic neurodegeneration.', 'CONCLUSION: ASS234 is a promising alternative drug of choice to treat the cognitive decline and neurodegeneration underlying Alzheimer disease.'], ['Alzheimer disease (AD) is a chronic neurodegenerative disease with no effective cure so far.'], ['OBJECTIVES: Depression in late life has been associated with difficulties in cognitive processing, particularly in the domains of executive function, processing speed and memory, and increases the risk of developing dementia suggesting a neurodegenerative phenotype.', 'Mitochondrial dysfunction is frequently an early event in neurodegenerative illnesses and may be operative in patients with late life depression.'], ["Parkinson's disease (PD) is a neurodegenerative aging disorder in which postmortem PD brain exhibits neuroinflammation, as well as synucleinopathy-associated protein phosphatase 2A (PP2A) enzymatic activity loss."], ["BACKGROUND: Fahr's disease is rare a neurodegenerative idiopathic condition characterized by symmetric and bilateral calcifications of basal ganglia, usually associated with progressive neuropsychiatric dysfunctions and movement disorders."], ['Abeta then triggers an immune response that drives neuroinflammation and neurodegeneration in AD.', 'The specific role of gut microbiota in modulating neuro-immune functions well beyond the gastrointestinal tract may constitute an important influence on the process of neurodegeneration.'], ['Finally, OT could potentially contribute to maintain social capacities of aged people and to ameliorate socially emotional deficits and symptoms of neurodegenerative diseases.'], ['As our capacity to unravel the control and regulatory properties of these networks and their dynamics under normal or pathological conditions broadens, so is our ability to address endogenous rhythms and clocks to improve health-span in human aging, and to manage complex metabolic disorders, neurodegeneration, and cancer.'], ["In the brain, TD causes a cascade of events including mild impairment of oxidative metabolism, neuroinflammation, and neurodegeneration, which are commonly observed in neurodegenerative diseases, such as Alzheimer's disease (AD), Parkinson's disease (PD), and Huntington's disease (HD).", 'Thiamine metabolites may serve as promising biomarkers for neurodegenerative diseases, and thiamine supplementations exhibit therapeutic potential for patients of some neurodegenerative diseases.', 'Experimental TD has been used to model aging-related neurodegenerative diseases.', 'However, to date, the cellular and molecular mechanisms underlying TD-induced neurodegeneration are not clear.', 'Recent research evidence indicates that TD causes oxidative stress, endoplasmic reticulum (ER) stress, and autophagy in the brain, which are known to contribute to the pathogenesis of various neurodegenerative diseases.', 'In this review, we discuss the role of oxidative stress, ER stress, and autophagy in TD-mediated neurodegeneration.', 'We propose that it is the interplay of oxidative stress, ER stress, and autophagy that contributes to TD-mediated neurodegeneration.'], ["Both activation and inhibition of SIRT1 were previously shown to ameliorate neuropathological mechanisms in Huntington's disease (HD), a neurodegenerative disease that selectively affects the striatum and cortex and is commonly linked to mitochondrial dysfunction."], ['In the present study, we provide results from neuropathological analyses of four supercentenarian autopsy cases using conventional and immunohistochemical analysis for neurodegenerative disorders.'], ['The role of autophagy in diverse cellular processes such as metabolic stress, neurodegeneration, cancer, aging, immunity, and inflammatory diseases is being increasingly recognized.'], ['Positive effects have been observed on genes involved in the pathobiology of most prevalent age- and lifestyle-related human conditions, such as cancer, cardiovascular disease and neurodegeneration.'], ['A fundamental question of whether such changes are causal remains to be demonstrated, but it is already clear that well-powered investigations of the human epigenome in the target organ of a neurodegenerative disease are feasible, are implicating new areas of the genome in the disease, and will be an important tool for future studies.'], ["Parkinson's disease (PD) is the second most common neurodegenerative disorder of aging."], ['OBJECTIVE: To investigate the effect of enriching mild cognitive impairment (MCI) clinical trials using combined markers of amyloid pathology and neurodegeneration.', "METHODS: We evaluate an implementation of the recent National Institute for Aging-Alzheimer's Association (NIA-AA) diagnostic criteria for MCI due to Alzheimer disease (AD) as inclusion criteria in clinical trials and assess the effect of enrichment with amyloid (A+), neurodegeneration (N+), and their combination (A+N+) on the rate of clinical progression, required sample sizes, and estimates of trial time and cost."], ['Importance: Preclinical Alzheimer disease (AD) can be staged using a 2-factor model denoting the presence or absence of beta-amyloid (Abeta+/-) and neurodegeneration (ND+/-).', 'Results: Among the 174 participants (81 men [46.6%]; 93 women [53.4%]; mean [SD] age, 65.7 [8.9] years), a proportion (14%-17%) of individuals with neurodegeneration alone (SNAP) later demonstrated Abeta+.'], ['Importance: A substantial proportion of clinically normal (CN) older individuals are classified as having suspected non-Alzheimer disease pathophysiology (SNAP), defined as biomarker negative for beta-amyloid (Abeta-) but positive for neurodegeneration (ND+).'], ["Alzheimer's disease (AD) is a progressive neurodegenerative disease that targets memory and cognition, and is the most common form of dementia among the elderly."], ['Mucopolysaccharidosis type II (MPSII) is a lysosomal storage disorder due to the deficit of the iduronate 2-sulfatase (IDS) enzyme, causing progressive neurodegeneration in patients.'], ['Although there still is conflicting evidence whether schizophrenia is a neurodegenerative disease, cognitive changes in schizophrenia resemble those observed during normal aging.'], ["Huntington's disease (HD) is late-onset, progressive neurodegenerative disorder caused by expansion of polyglutamine (polyQ) repeat within Huntingtin (Htt) protein."], ["Alzheimer's disease (AD) is a progressive neurodegenerative disorder that accounts for the most cases of dementia."], ['NCVI is common in patients with neurodegenerative disorders including dementia.'], ["Emerging evidence suggests that poor oral health influences the initiation and/or progression of diseases such as atherosclerosis (with sequelae including myocardial infarction and stoke), diabetes mellitus and neurodegenerative diseases (such as Alzheimer's disease, rheumatoid arthritis and others)."], ["The most common age-related conditions are neurodegenerative disorders such as Parkinson's disease and blindness."], ["Alzheimer's disease (AD) is a progressive neurodegenerative disease characterised by amyloid beta (Abeta) plaques and tau neurofibrillary tangles in the brain."], ['This review highlights some of the key findings regarding O-GlcNAcylation in models of neurodegenerative diseases.'], ['The validity of the TDP-43 in AD staging scheme is not limited to AD and should be applied to assess TDP-43 pathology in post mortem brains of aged individuals to further elucidate the role of TDP-43 pathology in age associated neurodegeneration.'], ['In the last decade, polyphenols (particularly curcumin, resveratrol and tea catechins) have been under very close scrutiny as potential therapeutic agents for neurodegenerative diseases, diabetes, inflammatory diseases and aging.', 'Evidence from in vitro and in vivo studies on polyphenols have demonstrated that they may play an integral role in preventing and treating diseases associated with neurodegeneration.'], ["Parkinson's disease (PD) is a common neurodegenerative disorder that usually affects the elderly."], ["Alzheimer's disease (AD), one of the neurodegenerative disorders that may develop in the elderly, is characterized by the deposition of beta-amyloid protein (Abeta) and extensive neuronal cell death in the brain."], ['One of the bone diseases most common in an increasingly ageing population is osteoarthritis, also referred to as degenerative joint disease.'], ['The activity of CMA has been shown to decline with age and such decline, correlating with accumulation of damaged/oxidized/aggregated proteins, may contribute to tissue dysfunction and, possibly, neurodegeneration.', 'Herein, we review the recent knowledge regarding the molecular components, regulation and physiology of the CMA pathway, the contribution of impaired CMA activity to poor cellular homeostasis and inefficient response to stress during aging, and discuss the therapeutic opportunities offered by the restoration of CMA-dependent proteolysis in age-associated degenerative diseases.'], ['RESULTS AND DISCUSSION: The high prevalence of degenerative diseases of the joints in old age is analyzed in accordance with the results of the estimations, which showed that, in fact, most of the patients remain undetected, undiagnosed and untreated.'], ["Postmortem human brain grey matter from Brodmann's area (BA) 11 and BA47 derived from a cohort of 209 individuals without psychiatric or neurodegenerative disease, ranging in age from 16 to 91 years, were analysed for KALRN expression by Affymetrix exon array."], ['Pittsburgh compound B (PIB) positron emission tomography (PET) was used to select participants in the Mayo Clinic Study of Aging and the Mayo Alzheimer\'s Disease Research Center with elevated beta-amyloid, designated as "A+," and hippocampal volume and (18)fluorodeoxyglucose (FDG) positron emission tomography were used to characterize participants as having evidence of neurodegeneration ("N+") at the baseline evaluation.', 'Expansion of regional involvement and faster rate of neurodegeneration characterizes progression in the AD pathway.'], ['Outdoor air pollution has been linked to several health effects including oxidative stress and neuroinflammation that may ultimately result in neurodegeneration and cognitive impairment.', 'This review aims to evaluate the relationship between exposure to inhaled ambient particles and neurodegeneration.'], ['This decline suggests that deficiency in ET may be a risk factor, predisposing individuals to neurodegenerative diseases.'], ["Parkinson's Disease (PD) represents one of the most common neurodegenerative disorders in the elderly."], ['Using selected illustrative examples, we draw a picture of the role of proteomic analyses for the many disease contexts from inherited disorders caused by mutation in mitochondrial proteins to complex diseases like cancer, type 2 diabetes and neurodegenerative diseases.'], ['Longitudinal studies will better elucidate the associations between plasma tau, neurodegeneration, and cognition.'], ['The execution of such tasks is especially difficult for the elderly and for people with (neuro-) degenerative disorders.'], ['Mitochondrial dysfunction is pervasive in human pathologies such as neurodegeneration, diabetes, cancer, and pathogen infections as well as during normal aging.'], ['We evaluated 3 AD-related neurodegeneration biomarkers: hippocampal volume adjusted for total intracranial volume (HVa), FDG standardized uptake value ratio (SUVR) in regions of interest linked to AD, and cortical thickness in AD-related regions of interest.', 'CONCLUSIONS: In persons with AD dementia with elevated PiB SUVR, values of each neurodegeneration biomarker were associated with age.'], ["BACKGROUND: Alzheimer's disease (AD) is the most prevalent neurodegenerative disorder worldwide."], ["SIGNIFICANCE: Alzheimer's disease is a neurodegenerative disorder that is projected to exceed more than 100 million cases worldwide by 2050."], ["In recent years, we have witnessed a significant increase in knowledge regarding Lon's involvement in physiological functions, as well as in an expanding array of human disorders, including cancer, neurodegeneration, heart disease, and stroke."], ['This process is accelerated in neurodegenerative disease.'], ['Bone loss associated with degenerative disease and trauma is a clinical problem increasing with the aging population.'], ['In humans, hundreds of mutations in the LMNA gene have been identified and correlated with over a dozen degenerative disorders, referred to as laminopathies.'], ['Based on this knowledge we can better recognize when age-related brain changes vary from these expectations especially during neurodegenerative diseases progression where the functioning of subcortical structures is altered.'], ['PD-associated neurodegeneration is relatively limited to dopaminergic neurons of the substantia nigra pars compacta (SNpc), especially in cases in which patients inherit particular disease-causing mutations.', 'Understanding the mechanisms of neurodegeneration in these forms of PD may not only shed light on avenues leading toward therapeutic strategies in PD and other neurodegenerative diseases, but also on those leading toward understanding natural ageing.', 'Neurodegeneration in PD patients harboring homozygous loss-of-function mutations in the PARK2 gene may result from unbalanced levels of ROS, which are mostly produced in mitochondria and can irreparably damage macromolecules and trigger apoptosis.', 'This review discusses mitochondrial sources of ROS, how ROS can trigger apoptosis, mechanisms by which Parkin loss-of-function may cause neurodegeneration by increasing ROS levels, and concludes with hypotheses regarding selective SNpc dopaminergic neuron vulnerability.'], ['Conversely, dementia onset is associated with a decrease of blood pressure values, probably secondary to neurodegeneration.'], ["BACKGROUND: The use of Serious exerGames (SeG) as enriched environments (EE), which promotes cognitive simulation with physical activity in a positive emotional context, has been proposed to represent a powerful method to slow down the decline due to neurodegenerative diseases (ND), such as Alzheimer's disease (AD).", 'However, so far, no SeG targeting EE has been tested in ND subjects.', 'OBJECTIVE: This study aimed at evaluating the usability and short-term training effects of X-Torp, an action SeG designed for elderly ND subjects with mild cognitive impairment (MCI) and AD.', '10 ND subjects and 8 healthy elderly controls (HEC) were enrolled in a 1-month program with three training sessions per week.', 'ND subjects played less and had a lower game performance compared to HEC.', 'During the sessions, ND subjects maintained a light intensity of aerobic activity, while HEC maintained a moderate intensity.'], ["Recent evidence suggests a strong relationship between MDD and neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), Amyotrophic Lateral Sclerosis (ALS), as well as natural processes of aging.", 'Changes in the neuroplasticity, morphology, and neurotransmission in the brain are seem to be associated to both, MDD and neurodegenerative diseases.', 'This review will highlight the relationship between MDD, the aging process, and neurodegenerative diseases, emphasizing the neurochemical processes involved.'], ['Cerebrovascular aging has a high relationship with stroke and neurodegenerative disease.', 'These results indicate that FGF21 protects against Ang II-induced cerebrovascular aging via improving mitochondrial biogenesis and inhibiting p53 activation in an AMPK-dependent manner, and highlight the therapeutic value of FGF21 in cerebrovascular aging-related diseases such as stroke and neurodegenerative disease.'], ['Old age is the greatest risk factor for most neurodegenerative diseases.'], ['OBJECTIVE: Neuropsychologists have an important role in evaluating patients with fragile X-associated disorders, but most practitioners are unaware of the recently identified neurodegenerative movement disorder known as fragile X-associated tremor ataxia syndrome (FXTAS).', 'The objective of this editorial is to orient the reader to FXTAS and highlight the importance of clinical neuropsychology in describing the fragile X premutation phenotype and the role practitioners may have in assessing and monitoring patients with or at risk for neurodegeneration.', 'CONCLUSIONS: The issue highlights the importance of awareness of fragile X-associated disorders for neuropsychologists, an awareness that must reach beyond neurodevelopmental aspects related to fragile X syndrome into the realm of neurodegenerative disease and aging.'], ['Oxidative stress is involved in the development of aging-related diseases, such as neurodegenerative diseases.'], ['BACKGROUND: Sleep disturbance is implicated in memory function across normal aging and neurodegenerative disease.'], ['Here, we review the complexities involved in the clinical management of FXTAS and consider how targeted treatment for these clinical features of FXTAS will result from advances in our understanding of the molecular mechanisms that underlie this neurodegenerative disorder.'], ['While AMD is a retinal disease, AD is reported to affect not only the brain but also the retina, with Abeta deposits, neurodegeneration and vascular changes.'], ["Altogether, results support the hypothesis that it is the PE's antioxidant asset, which is responsible for its life-prolonging effect and thus could be exploited in the therapeutics of ROS-associated abnormalities including aging and neurodegeneration in eukaryotes."], ['Misfolding and aggregation of proteins (amyloid-beta and tau) in the brain is the primary cause of neurodegeneration in the disease.'], ['Some structurally diverse synthetic compounds, such as SRT1720, SRT1460, Selisistat (EX 527), and AGK2 were used as small molecular SIRT modulators (IC50 = 0.04-100 muM) to treat ischemic stroke, myocardial infarction, neurodegenerative diseases, cancer, aging, and obesity.'], ['Awareness of the Abeta accumulation in these markedly different degenerative disorders has led to an increasing body of work exploring overlapping mechanisms, a prospective biomarker role for Abeta and the potential to use retina as a model for brain related neurodegenerative disorders.'], ['Although the accumulation and deposition of amyloid beta (Abeta) peptides in the brain is viewed as one of the pathological hallmarks of AD and underlies, at least in part, brain cell dysfunction and behavior alterations, the etiology of this neurodegenerative disease is still poorly understood.'], ["Alzheimer's disease (AD) is a devastating neurodegenerative disorder that causes progressive cognitive decline."], ['The inactivation of anti-oxidant enzymes induces oxidative stress in aging, diabetes and neurodegenerative disorders.', 'These results suggest that glycation as well as glycosylation are involved in oxidative stress that is associated with aging, diabetes and neurodegenerative diseases such as AD.'], ['Cluster analysis was used to group individuals based on biomarkers of amyloid pathology (cerebrospinal fluid amyloid-beta42/amyloid-beta40 assay levels), magnetic resonance imaging-derived measures of neurodegeneration/atrophy (cerebrospinal fluid-to-brain volume ratio, and hippocampal volume), neurofibrillary tangles (cerebrospinal fluid phosphorylated tau181 assay levels), and a brain-based marker of vascular risk (total white matter hyperintensity lesion volume).'], ['Here, we will briefly describe the key features of Tau pathology and its heterogeneity across various neurodegenerative diseases bearing cerebral Tau inclusions (i.e., tauopathies).'], ['Alzheimer disease (AD) is a progressive neurodegenerative disease that affects the elderly population with complex etiology.', 'In this review, we focus attention on the oxidative-stress hypothesis of neurodegeneration and we discuss redox proteomics approaches to analyze post-mortem human brain from AD brain.', 'In particular, we discuss the evidence demonstrating the oxidation/dysfunction of a number of enzymes specifically involved in energy metabolism that support the view that reduced glucose metabolism and loss of ATP are crucial events triggering neurodegeneration and progression of AD.'], ['Materials and Methods CMBs are associated with aging and neurodegenerative disorders.'], ['Recently, many clinical and experimental studies have demonstrated the importance of n-3 PUFA in counteracting neurodegeneration and agerelated dysfunctions.', 'METHODS: This review will focus on the neuroprotective effects of n-3 PUFA on cognitive impairment, neuroinflammation and neurodegeneration during normal aging.'], ['Our results might aid in unraveling and controlling check points relevant for ageing-associated aberrant adipogenesis with consequences for the treatment of degenerative diseases such as osteoporosis and for skeletal tissue engineering strategies.'], ['The prevalence of neurodegenerative diseases such as Parkinson disease (PD) will increase substantially, due to the aging of the population and improved treatments leading to better disease-related outcomes.'], ['We also discuss some of the main challenges in the use of iPSCs to model complex, late-onset neurodegenerative diseases such as dementias.'], ['Insights gained from the peculiar susceptibility of retinal ganglion cells to mitochondrial dysfunction are likely to inform therapeutic development for glaucoma and other common neurodegenerative diseases of aging.'], ['Moreover, understanding the mechanisms behind higher susceptibility to AGD of low SES subjects may disclose novel environmental risk factors for AGD and other neurodegenerative diseases.'], ['Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are two fatal neurodegenerative diseases seen in comorbidity in up to 50 % of cases.'], ["Recent evidence suggests these functions may be altered in neurodegenerative diseases such as Alzheimer's (AD) and Parkinson's disease (PD)."], ['While anxiety may affect memory performance, future studies are needed to explore if anxiety symptom may reflect early neurodegeneration that easily escapes clinical attention.'], ['We describe our strategy and discuss how we have used the SSV evaluation system to discover candidate causal variants related to complex neurodegenerative diseases.', 'We present the SSV evaluation system as a powerful tool to guide genetic investigations aiming to uncover SSVs that underlie human complex diseases including neurodegenerative diseases in aging.'], ['Healthy skeletal muscle harbors a robust regenerative response that becomes inadequate after large muscle loss or in degenerative pathologies and aging.'], ["Excitotoxicity has been implicated in the pathogenesis of a myriad of neurodegenerative diseases with distinct etiologies such as Alzheimer's and Parkinson's.", 'Numerous studies link apolipoprotein D (apoD), a secreted glycoprotein highly expressed in the central nervous system (CNS), to maintain and protect neurons in various mouse models of acute stress and neurodegeneration.'], ['Since the discovery that prion diseases can be transmitted to experimental animals by inoculation with afflicted brain matter, researchers have speculated that the brains of patients suffering from other neurodegenerative diseases might also harbor causative agents with transmissible properties.'], ["Therapeutic agents are urgently required to cure several common and fatal neurodegenerative disorders caused by protein misfolding and aggregation, including amyotrophic lateral sclerosis (ALS), Parkinson's disease (PD), and Alzheimer's disease (AD).", 'Protein disaggregases that reverse protein misfolding and restore proteins to native structure, function, and localization could mitigate neurodegeneration by simultaneously reversing 1) any toxic gain of function of the misfolded form and 2) any loss of function due to misfolding.', 'Nevertheless, vicissitudes of aging, environment, or genetics conspire to negate these disaggregase systems in neurodegenerative disease.'], ['Combined hernias represent a frequent clinical condition in the elderly consequent to long-term degenerative damage.'], ['Despite accumulating evidence from animal studies demonstrating that general anesthesia leads to neurodegeneration and cognitive impairment, to date a clear consensus on the impact of anesthetics in humans remains elusive.'], ['Osteoarthritis (OA) is the most prevalent degenerative joint disease with multifactorial etiology caused by risk factors such as ageing, obesity and trauma.'], ["BACKGROUND: Alzheimer's disease (AD) is a neurodegenerative disease of the brain and the most common form of dementia in the elderly.", 'Aneuploidy, a state in which cells have an abnormal number of chromosomes, has been proposed to play a role in neurodegeneration in AD patients.'], ['Combinations of the following phrases that describe the age group ("elderly," "non-elderly," "old," "age") and the disease of interest as well as management ("surgical outcome," "surgery," "cervical spondylotic myelopathy," "cervical degenerative myelopathy") were constructed when searching for relevant articles.'], ['More recently, efforts have shifted to the development of a more accurate model to decipher the precise mechanisms of neurodegeneration, using induced pluripotent stem cells derived from SA SCA7 patients.'], ['BACKGROUND: Dementia with Lewy bodies (DLB) is the second most common neurodegenerative dementia affecting the elderly.'], ['Cell therapy, to replace lost tissue, is a promising approach for the treatment of various neurodegenerative diseases.'], ['During the last years, proteomics has emerged as a large-scale comprehensive approach to characterize and quantify specific olfactory-related proteomes in different biological conditions such as olfactory learning, neurodegeneration, and ageing between others.'], ['Dementia is a neurodegenerative disorder that can have a severe effect on the quality of life of individuals with the condition, and can place considerable strain on informal carers and healthcare systems.'], ['MMP12 was found co-expressed with alpha-SMA, FSP1 and FAP-alpha in human and rat degenerative IVDs.'], ['There is accumulating evidence that the recruitment of tissue-resident and circulating cells is critical for organ homeostasis and effective injury responses, whereas the pathobiology of degenerative diseases, neoplasm and aging, might be rooted in the altered ability of immature cells to migrate.'], ['Augmentation of mast cells and EC cell numbers and the mast cell-nerve association suggest a compensatory mechanism for sensory neurodegeneration.'], ['Given that StARD3 is also involved in cholesterol transportation, a process that is aberrant in neurodegenerative diseases, the potential protective function of lutein against these diseases remains to be explored.'], ['The Keap1-Nrf2-ARE ((Kelch-like ECH-Associating protein 1) nuclear factor erythroid 2 related factor 2-antioxidant response element) pathway is one of the most important defense mechanisms against oxidative and/or electrophilic stresses, and it is closely associated with inflammatory diseases, including cancer, neurodegenerative diseases, cardiovascular diseases, and aging.'], ['Currently no effective disease-modifying treatment exists for the majority of neurodegenerative diseases.'], ["Alzheimer's disease (AD) is a chronic neurodegenerative disorder and is the most common cause of dementia worldwide."], ['Mitochondrial respiration is particularly active during the pathological aging of human cells in neurodegenerative diseases.'], ['Longitudinal analyses are necessary to determine whether higher adiponectin predicts neurodegeneration and cognitive decline.'], ['These changes occur earlier, faster, and to a greater degree as a result of neurodegeneration.'], ['Various BAG3 functions are implicated in disorders including cancer, myopathies, and neurodegeneration.'], ["Alzheimer's disease (AD) is the most common type of dementia and age-related neurodegenerative disease.", 'Elucidating the cellular changes that occur during ageing is an important step towards understanding the pathogenesis and progression of neurodegenerative disorders.'], ['The link between trace elements imbalances (both "toxic" and "essential") in the human brain and neurodegenerative disease has been subject of extensive research.', "More recently, some studies have highlighted the potential role of the homeostasis deregulation of alkali metals in specific brain regions as key factor in the pathogenesis of neurodegenerative diseases such as multiple sclerosis and Alzheimer's disease."], ['DISCUSSION: The combined properties of neuroprotection, neurogenesis, and memory enhancement in a single drug are more likely to be effective for the treatment of age-associated neurodegenerative disorders than any individual activity alone.'], ['DISCUSSION: Cognitive reserve appears to exert a protective effect regarding cognitive decline in normal and pathological populations, thus masking, at least in the early phases of neurodegeneration, the decline of memory, orientation, attention, language, and reasoning skills.'], ['In turn, these metabolic responses can affect the onset of insulin resistance, obesity, neurodegenerative disease, and other age-related diseases.'], ["The brain is particularly vulnerable to disease, and this is reflected in the onset of age-related neurodegenerative diseases such as Alzheimer's disease.", 'Research shows that dysfunction of two barriers in the central nervous system (CNS), the blood-brain barrier (BBB) and the blood-cerebrospinal fluid (CSF) barrier (BCSFB), plays an important role in the progression of these neurodegenerative diseases.'], ["Through its diverse roles in the brain, Klotho has become a new therapeutic target for neurodegenerative diseases such as Alzheimer's disease and demyelinating diseases like multiple sclerosis."], ["DNA modification analysis of twins affected with Alzheimer's disease reveals a potential for accelerated epigenetic assimilation in neurodegenerative disease."], ['BACKGROUND: Apoptosis takes place in naturally occurring neuronal death, but also in aging, neurodegenerative disorders, and traumatic brain injuries.', 'Due to the pivotal role of Casp3 in apoptosis, our approach is relevant for a better comprehension of molecular neurodegeneration in the normal and pathological brain.'], ['Mutant variants of triggering receptor expressed on myeloid cells 2 (TREM2) have recently been linked to late-onset AD and other neurodegenerative disorders.'], ['BACKGROUND: A certain number of mutations in the Microtubule-Associated Protein Tau (MAPT) gene have been identified in individuals with high risk to develop neurodegenerative diseases, collectively called tauopathies.', 'How A152TMAPT causes neurodegeneration remains elusive.'], ['Numerous studies have shown that maintaining a minimum quantity and quality of physical exercise decreases the risk of cardiovascular mortality, sarcopenia, prevents the onset of osteopenia and even exerts a prophylactic role against neurodegeneration.'], ['OBJECTIVE: To test the hypothesis that different forms of neurodegeneration are differentially related to longitudinal cognitive trajectories in old age.'], ['In addition, the study aimed to correlate the expression of Syn with neurodegeneration.'], ['As technology has advanced, our ability to study the anatomical and physiological function of synapses in greater detail has revealed a critical role for both central and peripheral synapses in neurodegenerative disease.', 'Synaptic changes in normal brain ageing will also be discussed and finally the current and prospective treatments for neurodegenerative disorders will be summarised.'], ['Decreased AbetaPP levels may be related to lower allostasis of synapses in the aged brain and their greater susceptibility to dysfunction characteristic of the onset of neurodegenerative disorders.'], ['Our findings suggest that further longitudinal assessment is required to investigate changes in cognitive outcome measures, ideally in conjunction with biological markers of neurodegeneration.'], ["BACKGROUND: Alzheimer's disease (AD) is a common and severe neurodegenerative disorder.", 'CONCLUSIONS: Our results show a consistent evidence of shorter telomeres in AD patients and highlight the importance of the analysis of epigenomic markers associated with neurodegeneration and with the risk for common and severe neurological diseases, such as AD.'], ["We have shown earlier that prolonged administration of recombinant human HSP70 to mice exhibiting Alzheimer's-like neurodegeneration as well as during sepsis reduces the clinical manifestations of these pathologies."], ["Age-related neurodegenerative disorders, like Alzheimer's or Parkinson's disease, are becoming a major issue to public health care.", 'Here, we aim to explore the role of exercise-induced trophic factor enhancement in the prevention or delay of cognitive decline in patients with neurodegenerative diseases.', 'Several trials with elderly individuals and patients with neurodegenerative diseases report exercise induced cognitive improvements and changes on trophic factor levels including BDNF, IGF-I, among others.'], ['Because of the multifactorial nature of this neurodegenerative disorder and its complex relationship with aging, however, it remains unclear whether such changes are the result of nonspecific dysregulation and multisystem failure or instead are part of a coordinated response to cellular dysfunction.'], ["Lead has also been shown to induce latent changes in the aging brain, and has been implicated in the pathogenesis of neurodegenerative diseases, particularly Alzheimer's Disease, and Parkinson's.", 'Epigenetic modification could potentially provide us a mechanism by which the environment, and toxic exposures contribute to the increased susceptibility of adult neurodegenerative disease.'], ['Pathological changes of the aging brain are expressed in a range of neurodegenerative disorders that will impact increasing numbers of people across the globe.', 'We discuss a strategic shift that seeks to identify the environmental causes or contributions to neurodegeneration, and the vision of primary disease prevention by removing or controlling exposure to culpable agents.', "Neurotoxin dosage and/or subject age at exposure might explain the stratified epidemic of neurodegenerative disease on Guam in which high-incidence ALS peaked and declined before that of PD, only to be replaced today by a dementing disorder comparable to Alzheimer's disease."], ['Unique pathologies, such as osteoporosis and degenerative deformities, must be recognized and treated.', 'Management of degenerative deformity must address sagittal plane balance, which includes consideration of pelvic incidence.'], ['Not surprisingly alterations in the biology of the mitochondria have implications in a wide array of diseases including cancer and age-related diseases such as neurodegeneration.'], ['Dysregulated mitochondrial quality control is closely associated with the progression of aging related diseases, such as cancers and neurodegenerative disorders.'], ["Moreover, other data indicate a possible pathogenetic role of subclinical chronic B vitamin deficiency in neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis."], ["We suggest that 'the discrepancy between histology and behavior' may be a universal feature that is associated with various aspects of neurodegenerative diseases.", 'Furthermore, given that the cognitive reserve is specifically observed in human brains, human behavior may be evolutionally distinct from that in other animals, thus, contributing to the differential efficiency of therapy between human and lower animals, an important issue in the therapy of neurodegenerative diseases.', "Overall, it is important to better understand 'the discrepancy between histology and behavior' in the mechanism of neurodegeneration for the development of effective therapies against neurodegenerative diseases."], ['The cytoskeleton not only provides structure, it is an active component of cell function, and in several neurodegenerative disorders, there is evidence of cytoskeletal collapse.'], ['This review resumes the association between mitochondrial function and diseases, especially neurodegenerative diseases.'], ["BACKGROUND: Alzheimer's disease (AD) is a neurodegenerative brain disease that causes cognitive impairment and dementia."], ['We summarize adult neurogenesis in aging, ischemic stroke, traumatic brain injury, and neurodegenerative disease and review the advances of targeting NAMPT in restoring neurogenesis.'], ['The baseline GEPCI-based biomarkers obtain herein could serve to help distinguish age-related changes in brain cellular and hemodynamic properties from changes which occur due to the neurodegenerative diseases.'], ['Prevention of progression in neurological diseases, particularly in multiple sclerosis (MS) but also in neurodegenerative diseases, remains a significant challenge.'], ["An aging population faces an increasing incidence of neurodegenerative disease and the pathological action of nitric oxide in Alzheimer's and Parkinson's diseases may be important therapeutic targets for the future."], ['Base excision repair (BER) is an essential DNA repair pathway involved in the maintenance of genome stability and thus in the prevention of human diseases, such as premature aging, neurodegenerative diseases, and cancer.'], ['The relationship between daily computer use (DCU) and imaging markers of neurodegeneration is unknown.', 'OBJECTIVE: The objective of this study was to examine the relationship between average DCU and volumetric markers of neurodegeneration on brain MRI.', 'Continuous monitoring of daily computer use may detect signs of preclinical neurodegeneration in older individuals at risk for dementia.'], ['CONCLUSION: Diverse sources of baseline and longitudinal data will provide rich opportunities to investigate pathways linking vascular and cerebrovascular health, clinical and pathological AD, and neurodegeneration contributing to novel strategies to delay or prevent cognitive decline.'], ['High levels of caloric expenditure moderated neurodegeneration-associated volume loss in the precuneus, posterior cingulate, and cerebellar vermis.'], ['A lifestyle characterized by experiences of mental stimulation may help to cope aging and HIV-related neurodegeneration.'], ['Sleep-wake cycles are known to be disrupted in people with neurodegenerative disorders.', 'Mechanisms underlying the connection between circadian/sleep dysregulation and neurodegeneration remain unclear, but several recent studies provide interesting possibilities.', 'While mechanistic analysis is under way, it is worth considering treatment of circadian/sleep disruption as a means to alleviate symptoms of neurodegenerative disorders.'], ['However, instability of state control occurring with aging generally and among many neurodegenerative diseases raises the possibility that FIRDA might represent the intrusion of sleep related elements of the EEG into the waking state.'], ["Alzheimer's disease (AD) is the most common neurodegenerative disease, characterized by amyloid plaque deposition and formation of neurofibrillary tangles."], ['Thus, the A152T substitution may augment risk for neurodegenerative diseases by increasing hTau protein levels, promoting network hyperexcitability, and synergizing with the adverse effects of other pathogenic factors.'], ['Accumulation of DNA damage can lead to multiple diseases such as neurodegenerative disorders, cancers, immune deficiencies, infertility, and also aging.', 'Importantly, various point mutations within the FET genes have been implicated in pathological protein aggregation in neurodegenerative diseases, specifically with amyotrophic lateral sclerosis (ALS), and frontotemporal lobe degeneration (FTLD).'], ['Importantly, many neurodegenerative disorders first manifest between midlife and old age, and normative estimates may provide a reference for differential change associated with such disorders.'], ['Therefore, the progression and outcome of neurological and neurodegenerative diseases depend on glial reactions.'], ['The use of transgenic models for the study of neurodegenerative diseases has made valuable contributions to the field.', 'However, some important limitations, including protein overexpression and general systemic compensation for the missing genes, has caused researchers to seek natural models that show the main biomarkers of neurodegenerative diseases during aging.'], ['OBJECTIVE: To investigate the effect of age, sex, APOE4 genotype, and lifestyle enrichment (education/occupation, midlife cognitive activity, and midlife physical activity) on Alzheimer disease (AD) biomarker trajectories using longitudinal imaging data (brain beta-amyloid load via Pittsburgh compound B PET and neurodegeneration via (18)fluorodeoxyglucose (FDG) PET and structural MRI) in an elderly population without dementia.', 'RESULTS: Age was associated with amyloid and neurodegeneration trajectories; APOE4 status appears to influence only the amyloid and FDG trajectories but not hippocampal volume trajectory.'], ['Changes in the content of aggrecan, an essential proteoglycan of articular cartilage, have been implicated in the pathophysiology of osteoarthritis (OA), a prevalent age-related, degenerative joint disease.'], ['Several studies in vitro, in experimental animals and in humans, have provided supportive evidence for neuroprotective effects of quercetin, either against neurotoxic chemicals or in various models of neuronal injury and neurodegenerative diseases.'], ['CONCLUSION: Causal treatments for neurodegenerative diseases are now being developed and tested, and thus a molecular diagnosis is desirable.'], ['Preclinical Research In this review, we discuss epigenetic-driven methods for treating neurodegenerative disorders associated with mitochondrial dysfunction, focusing on carnitinoid antioxidant-histone deacetylase inhibitors that show an ability to reinvigorate synaptic plasticity and protect against neuromotor decline in vivo.'], ["Alzheimer's Disease (AD) is one of the most important neurodegenerative disorders in the 21st century for the continually aging population."], ["Deficiency of insulin signaling has been linked to diabetes and ageing-related neurodegenerative diseases such as Alzheimer's disease (AD).", 'As the derivation of induced pluripotent stem cells (iPSC) involves cell reprogramming, it may provide a means for regaining the control of ageing-associated dysfunction and neurodegeneration via affecting insulin-related signaling.'], ['We reviewed animal and human findings that suggest an overlap between processes of impaired neurogenesis, neurodegeneration, structural, functional, molecular, and cellular modifications in AnxDs, and aging.'], ['In human cell lines and in animal studies, phytoalexins have been shown to be highly beneficial, with protective effects against cancer, cardiovascular disease, neurodegenerative diseases, diabetes, hyperglycemia, as well as potential effects on longevity.'], ['In particular, a body of evidence suggests that neuronal metal ions such as copper, zinc, and iron play important roles in brain function in health and disease states and altered homeostasis and distribution as a common feature across different neurodegenerative diseases and aging.'], ['Nearly 90% of the spinal operations were performed for degenerative disorders, with their number increasing approximately 5-fold from 705 to 3,448.'], ['RATIONALE AND OBJECTIVES: Parkinson disease (PD) is a progressive neurodegenerative disorder affecting motor and cognitive functions.'], ['One of the priority topics of research about aging in nonhuman primates involves neurologic changes associated with cognitive decline and neurodegenerative diseases.'], ["In aging humans, the most common neurodegenerative disorder is Alzheimer's disease (AD), which progressively impairs cognition, behavior, and quality of life.", 'This review describes the commonly reported age-associated neurologic lesions in domestic and laboratory animals and the relationship of these lesions to cognitive dysfunction.', "Also described are the comparative interspecies similarities and differences to AD and other human neurodegenerative diseases including Parkinson's disease and progressive supranuclear palsy, and the spontaneous and transgenic animal models of these diseases."], ['This review provides an overview of the most commonly reported nonneoplastic macroscopic and microscopic pathologic findings in progeroid mouse models (eg, osteoporosis, osteoarthritis, degenerative joint disease, intervertebral disc degeneration, kyphosis, sarcopenia, cutaneous atrophy, wound healing, hair loss, alopecia, lymphoid atrophy, cataract, corneal endothelial dystrophy, retinal degenerative diseases, and vascular remodeling).'], ['SIRT1 plays a key role in the pathophysiology of metabolic diseases and neurodegenerative disorders, and is considered to protect against age-related diseases including cancer.'], ['The incidence of age related disorders (ARDs) such as cardiovascular diseases, cancer, arthritis, dementia, osteoporosis, diabetes, neurodegenerative diseases increase rapidly with aging.'], ['Disruptions in folate-mediated one-carbon metabolism (FOCM) are associated with risk for several pathologies including developmental anomalies such as neural tube defects and congenital heart defects, diseases of aging including cognitive decline, neurodegeneration and epithelial cancers, and hematopoietic disorders including megaloblastic anemia.'], ['At the genomic level, it has been demonstrated that heritable mtDNA mutations and variants affect mammalian stem cell homeostasis and influence the risk for human degenerative diseases during aging.', 'Because such a multitude of stem cell factors and signaling pathways ultimately converge on the mitochondria as the primary mechanism to modulate cellular and organismal longevity, it would be most efficacious to develop technologies to therapeutically target and direct mitochondrial repair in stem cells, as a unified strategy to combat aging-related degenerative diseases in the future.'], ['Drug discovery for neurodegenerative diseases is particularly challenging because of the discrepancies in drug effects between in vitro and in vivo studies.', 'First, few cell culture systems accurately model human aging or neurodegenerative diseases.', 'Our data suggest that BrnAggs could serve as an effective in vitro cell culture system for drug discovery for neurodegenerative diseases.'], ['The term "mild cognitive impairment" was adopted by Petersen in 2004 to describe a period in the course of neurodegenerative disease where cognition is no longer normal relative to age expectations, however, daily functions are not sufficiently disrupted to correlate with the diagnosis of dementia.', 'Neuropsychological assesment plays a substantial role in the diagnosis of MCI, especially in the case of identification of different MCI subtypes or typical profiles of cognitive performance in prodromal phases of neurodegenerative diseases.'], ['Genes mediating neuroinflammation and immune system activation in particular, show significant age-related upregulation creating a state of vulnerability to neurodegenerative and neuropsychiatric disease in the aging brain.', 'In doing so, new avenues for early intervention in age-related neurodegenerative disease could be investigated with potentially significant implications for the development of disease-modifying therapies.'], ['BACKGROUND: Metabolic syndrome (MetS), defined by a constellation of cardiometabolic pathologies, is highly prevalent among veterans, especially veterans with posttraumatic stress disorder (PTSD), and poses a major risk for adverse health outcomes, including neurodegeneration and mortality.', 'CONCLUSIONS: Results from this young veteran sample provide evidence that PTSD confers risk for cardiometabolic pathology and neurodegeneration and raise concern that this cohort may be aging prematurely and at risk for substantial medical and cognitive decline.'], ["BACKGROUND: Alzheimer's disease affects ~13% of people in the United States 65 years and older, making it the most common neurodegenerative disorder."], ['Age-related hearing loss (AHL) is a progressive neurodegenerative disease that is largely silent in its initial stages.'], ['METHODS: PD patients in the Arizona Study of Aging and Neurodegenerative Disorders were assessed with both scales.'], ['Protein deamidation has been proposed to represent a "molecular clock" that progressively disrupts protein structure and function in human degenerative diseases and natural aging.', 'These technological advances will lead to a better understanding of how deamidation contributes to the pathology of biological aging and major degenerative diseases.'], ['Therefore, understanding how this process evolves through the lifespan could offer insights into both the aging process and the development of aging-related neurodegenerative brain diseases.', 'The results offer insights into the aging process, but also offer a new approach to studying the role of iron dysregulation in the evolution of age-related neurodegenerative diseases.'], ["Tau deposition is one of the neuropathological hallmarks in Alzheimer's disease as well as in other neurodegenerative disorders called tauopathies."], ['The lack of effective therapies for neurodegenerative disorders is one of the most relevant challenges of this century, considering that, as the global population ages, the incidence of these type of diseases is quickly on the rise.'], ["Causative treatment strategies for Parkinson's disease (PD) will have to address multiple underlying pathomechanisms to attenuate neurodegeneration.", 'Considering the role of astro- and microglia in PD pathogenesis as well as beneficial effects of ROCK inhibition on neuronal survival and regeneration in neurodegenerative disease models, our data strengthens the importance of the ROCK pathway as a therapeutic target in PD.'], ['CONCLUSION: Mapping of signal phase from ultra-high field MRI data undoubtedly provides a wealth of information about the ageing brain and the effects of neurodegenerative disorders.'], ['Altered REST/NRSF expression has been not only related to deficient brain functions such as neurodegenerative diseases, mental disorders, brain tumors, and neurobehavioral disorders but also highly correlated to brain injuries such as alcoholism and stroke.', 'These findings strongly indicate that REST/NRSF is not only a classical repressor to maintain normal neurogenesis, but it is also a fine fundamental protector against neurodegeneration and other disorders and may be a novel potent therapeutic target for neural disturbances.'], ['Alzheimer disease (AD) is one of the most common neurodegenerative diseases and the most prevalent form of dementia.'], ['Neurodegenerative disorders are characterized by decreased regional cerebral blood flow.'], ["BACKGROUND: Global brain atrophy is present in normal aging and different neurodegenerative disorders such as Alzheimer's disease (AD) and is becoming widely used to monitor disease progression."], ['Hence, when failing mitochondria place the cell in energy crisis there are major effects on gene expression affecting the risk of degenerative diseases, cancer and ageing.'], ['Neurodegenerative disease is more vulnerable to an accelerated brain ageing, which is associated with prospective cognitive decline and disease severity.', 'Therefore, we believe the method can provide a possible way to quantitatively describe the typical and atypical network organization of human brain and serve as a biomarker for presymptomatic detection of neurodegenerative diseases in the future.'], ['The elucidation of some of the mechanisms responsible for hypoperfusion in AD and for the interactions between CVD and AD has led to the identification of several novel therapeutic approaches that have the potential to ameliorate ischaemic damage and slow the progression of neurodegenerative disease.'], ["Noise driven exploration of a brain network's dynamic repertoire has been hypothesized to be causally involved in cognitive function, aging and neurodegeneration."], ["Alzheimer's disease (AD) is a neurodegenerative disorder and the most common cause for dementia, which affects approximately 120 thousand people in Switzerland and 35 million worldwide."], ['Osteoarthritis (OA) is a degenerative disorder of the joint, principally occurring during aging, and characterized by a focal degradation of cartilage.'], ["In this article we will: (i) consolidate some of our still evolving ideas concerning the role of miRNAs in the CNS in normal aging and in health, and in sporadic Alzheimer's disease (AD) and related forms of chronic neurodegeneration; and (ii) highlight certain aspects of the most current work in this research field, with particular emphasis on the findings from our lab of a small pathogenic family of six inducible, pro-inflammatory, NF-kappaB-regulated miRNAs including miRNA-7, miRNA-9, miRNA-34a, miRNA-125b, miRNA-146a and miRNA-155.", 'This group of six CNS-abundant miRNAs significantly up-regulated in sporadic AD are emerging as what appear to be key mechanistic contributors to the sporadic AD process and can explain much of the neuropathology of this common, age-related inflammatory neurodegeneration of the human CNS.'], ['Long term flavonoid supplementation over a period of weeks or months has been extensively investigated and reviewed, particularly with respect to cognitive ageing and neurodegenerative disease.'], ['Activation of the immune system not initiated by an infectious agent, typifies the aging brain and is even more augmented in several neurodegenerative diseases.'], ["Although this type of cognitive impairment is usually considered the second most common form of dementia after Alzheimer's disease, there is increasing recognition of the vascular contribution to neurodegeneration, with both pathologies frequently coexisting."], ["Alzheimer's disease (AD) is an aging-related, degenerative brain disease of adults."], ['Mutations in the Drosophila NTE homolog swiss cheese (sws) cause early-onset, progressive behavioral defects and neurodegeneration characterized by vacuole formation.', 'Indeed, neuron-specific expression of wildtype human NTE is capable of rescuing mobility defects after 10 days of adult life at 29 C, when significant degeneration has already occurred, and significantly extends longevity of mutants at 25 C. These results raise the exciting possibility that late induction of NTE function may reduce or ameliorate neurodegeneration in humans even after symptoms begin.'], ['Age is considered a dominant risk factor in the development of most neurodegenerative disorders.', 'The kynurenine pathway, a major metabolic pathway of tryptophan is altered in the majority of neurodegenerative disorders.', 'We conclude that, the changes that occur in the kynurenine pathway as a result of normal ageing are mechanistically linked to increased inflammatory signalling and have some explanatory potential with regard to age-associated degenerative diseases in the CNS.', 'Of particular interest is the increase in QUIN, a neuroexcitotoxin associated with neurodegeneration.'], ['Molecular chaperone Heat Shock Protein 70 (Hsp70) plays an important protective role in various neurodegenerative disorders often associated with aging, but its activity and availability in neuronal tissue decrease with age.', 'The potential of eHsp70 intranasal treatment to protect synaptic machinery in old animals offers a unique pharmacological approach for various neurodegenerative disorders associated with human aging.'], ['As a consequence, chronic degenerative pathologies and a progressive dependance of people in their third age are becoming more and more common.'], ['Capillary flow patterns were, however, recently shown to limit the extraction efficacy of oxygen in tissue and capillary dysfunction therefore proposed as a source of stroke-like symptoms and neurodegeneration, even in the absence of physical flow-limiting vascular pathology.'], ["For example, simply modifying an animal's living environment to promote sensory stimulation can lead to (but is not limited to) enhancements in hippocampal cognition and neuroplasticity and can alleviate hippocampal cognitive deficits associated with neurodegenerative diseases and aging."], ['Common SNPs in DNA repair genes modify the effects of medical exposure to radiation LTL-related degenerative diseases.'], ['This study provides a better understanding of pathogenic functions of TMEM106B, which is a risk factor for the progression of neurodegenerative diseases that are associated with endosomal defects in the aged brain.'], ["Impairment of proteostasis has a prominent role in the pathophysiology of ageing-related neurodegenerative diseases including Huntington's, Parkinson's, and Alzheimer's disease."], ['Consequently, these progressive dysfunctions facilitate many human pathologies and deficits that are associated with aging, including cardiovascular, musculoskeletal, and neurodegenerative disorders and diseases.'], ['Social exclusion, low social activity, physical inactivity, poor mental performance, and low level of education are among risk factors for development of this neurodegenerative disease, which is consistent with the concept of phenoptosis (Skulachev, V. P., et al.'], ['They often possess strong antioxidant and free radical scavenging abilities, as well as anti-inflammatory action, which are also the basis of other bioactivities and health benefits, such as anticancer, anti-aging, and protective action for cardiovascular diseases, diabetes mellitus, obesity and neurodegenerative diseases.'], ['More importantly, the decreased sense of smell is an early symptom of neurodegenerative diseases such as Parkinson disease (PD) and Alzheimer disease.', 'In conclusion, we provide preliminary evidence that the MAPT locus may play a role in regulating the sense of smell in older adults and therefore offer a potential genetic link between poor sense of smell and major neurodegenerative diseases.'], ['Our results suggest a series of changes across a wide range of proteins in the human temporal lobe that may relate to aging and age-related neurodegenerative disorders.'], ['METHODS MSSIC focuses on lumbar and cervical spine surgery, specifically indications such as stenosis, disk herniation, and degenerative disease.'], ['Individuals at greatest risk of decline seem to be those with evidence of both amyloid-beta and findings suggestive of neurodegeneration.'], ['This suggests that b5R can be a target for therapeutic intervention for aging and neurodegenerative diseases.'], ["Neurodegenerative disorders such as Alzheimer's, Parkinson's and Huntington's diseases have high prevalence among the elderly."], ['BACKGROUND: Neurodegeneration is characterized by progressive neurological deficits due to selective neuronal loss in the nervous system.', "Huntington's disease (HD) is an incurable neurodegenerative disorder.", 'Neurodegeneration in HD patients shows aging-dependent pattern.', 'OBJECTIVE: To clarify possible mechanisms for neurodegeneration, which improves the understanding the aging process.', 'CONCLUSION: Our findings provide evidence that the herbal formula B401 can remedy for aging-dependent neurodegeneration of R6/2 mice via suppressing oxidative stress and apoptosis in the brain.', 'We suggest that the herbal formula B401 can be developed as a potential health supplement for ameliorating aging-dependent neurodegeneration.'], ['Therefore, (18)F-GE180 PET imaging may be useful for longitudinal monitoring of neuroinflammation during AD progression and treatment and may also be useful for other neurodegenerative diseases.'], ['UNLABELLED: The aging population in the U.S. and other developed countries has led to a large increase in the number of patients suffering from degenerative diseases.', 'Here we outline key policy changes and technological challenges that must be addressed to achieve the promise of a major breakthrough in the treatment of degenerative disease.', 'SIGNIFICANCE: Regenerative therapies, in which dysfunctional or degenerating cells, tissues, or organs are repaired or replaced, have the potential to cure chronic degenerative diseases.'], ['Late onset epilepsy is usually secondary to stroke, tumour, trauma or neurodegenerative disorders.'], ['DISCUSSION: Response rates are comparable to other registers reported in the literature, and indicate good interest and support for a research register and for participation in research for the prevention of age-related neurodegenerative diseases and dementia.'], ['Recent findings of brain-derived neurotrophic factors (BDNF) seem to have shed some light upon age-related neurodegenerative diseases and appear to influence energy metabolism, appetite and aspects of neuro-cognitive function.'], ['BACKGROUND: In a 2014 cross-sectional analysis, we showed that amyloid and neurodegeneration biomarker states in participants with no clinical impairment varied greatly with age, suggesting dynamic within-person processes.', '(18)F-fluorodeoxyglucose ((18)F-FDG)-PET and MRI were used to classify individuals as neurodegeneration positive (N(+)) or negative (N(-)).', 'The one exception is the transition to amyloidosis without neurodegeneration, which is most dynamic from age 60 years to 70 years and then plateaus beyond that age.'], ['CONCLUSIONS AND RELEVANCE: In persons selected from a population-based study, elevated amyloid levels at baseline were associated with worse cognition and imaging biomarkers at baseline and with greater clinical decline and neurodegeneration.'], ['However, in spite of the broad repertoire of iPSC-based disease models developed in recent years, increasing evidence suggests that this technology might not be fully suitable for the study of conditions of old age, such as neurodegeneration.', 'The difficulty in recapitulating late-stage features of disease in cells of pluripotent origin is believed to be a discrepancy between the fetal-like nature of iPSC-progeny and the advanced age of onset of neurodegenerative syndromes.'], ["In HIV-infected aging individuals, the potential synergy between immunosenescence and HIV viral loads increases susceptibility to HIV-related brain injury and functional brain network degradation similar to that seen in Parkinson's disease (PD), the second most common neurodegenerative disorder in the aging population."], ['These findings suggest that these age-related alterations may contribute to an increased susceptibility to pathogens or abnormally folded proteins with age in neurodegenerative diseases.'], ['BACKGROUND AND PURPOSE: Knowledge of age-related physiological changes in the human brain is a prerequisite to identify neurodegenerative diseases.'], ['Neurodegenerative diseases are among the most challenging diseases with poorly known mechanism of cause and paucity of complete cure.', "Out of all the neurodegenerative diseases, Alzheimer's disease is the most devastating and loosening of thinking and judging ability disease that occurs in the old age people."], ['Despite the fact that peripapillary RNFL thickness did not statistically differ in comparison to control eyes, the increase in peripapillary thickness in our mild-AD patients could correspond to an early neurodegeneration stage and may entail the existence of an inflammatory process that could lead to progressive peripapillary fiber damage.'], ['As degenerative disease is age-related and inflammation is implicated in its pathogenesis, our findings further support this association.'], ['Combined quantitative proteomic and bioinformatic analyses of the frontal cortex of FTD patients possessing elevated FLNC levels, identified multiple altered protein factors involved in accelerated aging, neurodegeneration and synaptogenesis.Our findings further support the involvement of aberrant FLNC expression levels in FTD pathogenesis.', 'Identification of increased FLNC levels in aged Grn mice and impaired pathways related to aging and neurodegeneration, implies a potential role for FLNC in mediating or accelerating the aging process.'], ["Regenerative medicine using patient's own stem cells (SCs) to repair dysfunctional tissues is an attractive approach to complement surgical and pharmacological treatments for aging and degenerative disorders."], ["Neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease and many others represent a relevant health problem with age worldwide.", 'Efforts have been made in recent years to discover the mechanism of neurodegenerative diseases and prospective therapy that can help to slow down the effects of the aging and prevent these diseases.', 'Since pathogenesis of these diseases involves multiple factors therefore the important task for neuroscientists is to identify such multiple factors and prevent age-associated neurodegenerative diseases.', 'For these neurodegenerative diseases yet we have only palliative therapies and none of them significantly capable to slow down or halt the underlying pathology.', 'Polyphenolic compounds such as flavonoids present in vegetables and fruits are believed to have anti-aging properties and reduce the risk of neurodegenerative diseases.', 'In this review, we elaborate the neuroprotective properties of flavonoids especially their applications in prevention and intervention of different neurodegenerative diseases.', 'Their multi-target properties may allow them to be potential dietary supplement in prevention and treatment of the age-associated neurodegenerative diseases.'], ['Age-related neurodegeneration, in particular, significantly impacts important sensory, motor, and cognitive functions, seriously constraining life quality of many patients.'], ['METHODS: The PD cohort was studied as part of the Arizona Study of Aging and Neurodegenerative Disorders (AZSAND).'], ["Neurodegenerative disorders are characterized by chronic and progressive loss of neurons in structure and function related to aging, such as Alzheimer's disease, the latter characterized by the degeneration of cholinergic neurons in basal forebrain connected to the cerebral cortex and hippocampus."], ['SMCs may be a very early symptom of an insidious neurodegenerative disease process, such as Alzheimer disease.'], ['Unique pathologies, such as osteoporosis and degenerative deformities, must be recognized and dealt with.', 'Management of degenerative deformity must address sagittal plane balance, including consideration of pelvic incidence.'], ['If unrepaired, these highly cytotoxic lesions cause genome instability, tumorigenesis, neurodegeneration or premature ageing.'], ['Based on these findings, we propose that chronic RCAN1 overexpression during aging alters DRP1-mediated mitochondrial fission and thus acts to promote AD-related progressive neurodegeneration.'], ['Primary Open Angle Glaucoma (POAG) is a common neurodegenerative disease characterized by the selective and gradual loss of retinal ganglion cells (RGCs).'], ['UNLABELLED: Misfolded proteins accumulate and aggregate in neurodegenerative disease.', 'We propose a novel pathophysiological function for RAD-23 in the stabilization of mutated proteins that cause neurodegeneration.'], ['Telomere shortening has been associated with biological age and several chronic degenerative diseases.'], ['RBD is a pre-clinical marker for a class of neurodegenerative diseases, the "synucleinopathies", and requires formal polysomnographic evaluation.'], ['Exercise prevents the decline of the hippocampus from aging and ameliorates many neurodegenerative diseases, in part by increasing adult hippocampal neurogenesis but also by activating a multitude of molecular mechanisms that promote brain health.'], ['Dyshomeostasis of both ceramides and sphingosine-1-phosphate (S1P) in the brain has been implicated in aging-associated neurodegenerative disorders in humans.'], ['Compromised autophagy has been implicated in many neurodegenerative diseases, including retinal degeneration.'], ["Alzheimer's disease (AD) is a progressive neurodegenerative disease that represents the most common form of dementia among the elderly.", 'Thus, mitochondrial dysfunction may represent the missing link between aging and sporadic AD, and represent attractive targets against neurodegeneration.'], ['Given that aging is the most important risk factor for most neurodegenerative diseases, our results may have far-reaching implications into other diseases.'], ['Functional loss of the protein has been linked to carcinogenesis, premature aging and neurodegeneration.'], ['in the presence of cancer and/or neurodegenerative disease conditions.'], ['In addition, neuromelanin released by degenerating neurons activates microglia and the latter cause neurons death with further release of neuromelanin, then starting a self-propelling mechanism of neuroinflammation and neurodegeneration.', 'Considering the above issues, age-related accumulation of neuromelanin in dopamine neurons shows an interesting link between aging and neurodegeneration.'], ['This includes the oxidation of RNA, which appears to underlie the detrimental effects of oxidative stress, aging and certain neurodegenerative diseases.'], ['With the increase in the ageing population, neurodegenerative disease is devastating to families and poses a huge burden on society.', 'Here we discuss features of the fly as a model for human neurodegenerative disease.', 'There are many distinct fly models for a range of neurodegenerative diseases; we focus on select studies from models of polyglutamine disease and amyotrophic lateral sclerosis that illustrate the type and range of insights that can be gleaned.'], ["Increasing incidence of neurodegenerative disorders such as Alzheimer's disease and Parkinson's disease has become one of the most challenging health issues in ageing humans.", 'One approach to combat this is to generate genetically modified animal models of neurodegenerative disorders for studying pathogenesis, prognosis, diagnosis, treatment, and prevention.', 'Owing to the genetic, anatomic, physiologic, pathologic, and neurologic similarities between pigs and humans, genetically modified pig models of neurodegenerative disorders have been attractive large animal models to bridge the gap of preclinical investigations between rodents and humans.', "In this review, we provide a neuroanatomical overview in pigs and summarize and discuss the generation of genetically modified pig models of neurodegenerative disorders including Alzheimer's diseases, Huntington's disease, Parkinson's disease, amyotrophic lateral sclerosis, spinal muscular atrophy, and ataxia-telangiectasia."], ["This paper reviews lifestyle and stress as possible factors contributing to AD and meditation's effects on cognition and well-being for reduction of neurodegeneration and prevention of AD."], ["Recent studies indicate that impairment of the normal structure and function of microglia, caused by either intense inflammatory activation (e.g., following infections, trauma, stroke, short-term stress, autoimmune or neurodegenerative diseases) or by decline and senescence of these cells (e.g., during aging, Alzheimer's disease, or chronic unpredictable stress exposure), can lead to depression and associated impairments in neuroplasticity and neurogenesis."], ['Elucidation of the AD mechanism and factors that contribute to the initiation, progression, and spreading of this chronic and fatal neurodegeneration will ultimately result in improved and effective diagnostics and therapeutic strategies.microRNAs (miRNAs) comprise a relatively recently discovered category of 20-24 nucleotide non-coding RNAs that function post-transcriptionally in shaping the transcriptome of the cell, and in doing so, contribute to the molecular-genetics and phenotype of human CNS health and disease.'], ["An age-associated variation in the content of Fe, Cu, Zn and Ca has recently received great interest in neurology, as these elements are implicated in different biochemical mechanisms underlying malicious neurodegenerative disorders, including Parkinson's and Alzheimer's diseases.", 'To do so, substantia nigra tissue specimens, drawn from 37 individuals who deceased without any signs of neurodegeneration, were subjected to spectroscopic studies using synchrotron radiation based X-ray fluorescence.'], ['IMPORTANCE: To understand how a model of Alzheimer disease pathophysiology based on beta-amyloidosis and neurodegeneration predicts the regional anatomic expansion of hypometabolism and atrophy in persons with mild cognitive impairment (MCI).', 'OBJECTIVE: To define the role of beta-amyloidosis and neurodegeneration in the subsequent progression of topographic cortical structural and metabolic changes in MCI.', 'They were further characterized initially by the presence or absence of neurodegeneration (N+ or N-), where the presence of neurodegeneration was defined by abnormally low hippocampal volume or hypometabolism in an Alzheimer disease-like pattern on 18fluorodeoxyglucose (FDG)-positron emission tomography.'], ['Increase in Marinesco bodies, alpha-synuclein, free radicals and so forth in the aging nigral neurons are clear indicators of neurodegeneration.'], ['We recently demonstrated that the frequencies of biomarker groups defined by the presence or absence of both amyloidosis (A+) and neurodegeneration (N+) changed dramatically by age in cognitively non-impaired subjects.', 'Our present objectives were to assess the consequences of defining neurodegeneration in five different ways on the frequency of subjects classified as N+, on the demographic associations with N+, and on amyloidosis and neurodegeneration (A/N) biomarker group frequencies by age.', 'The three continuous individual neurodegeneration measures were moderately correlated (rs = 0.42 to 0.54) but when classified as normal or abnormal had only weak agreement (kappa = 0.20 to 0.29).', "For all definitions of neurodegeneration, (i) the frequency of A-N- was 100% at age 50 and declined monotonically thereafter; (ii) the frequency of A+N- increased from age 50 to a maximum in the mid-70s and declined thereafter; and3 (iii) the frequency of A-N+ (suspected non-Alzheimer's pathophysiology) and of A+N+ increased monotonically beginning in the mid-50s and mid-60s, respectively.", 'Overall, different neurodegeneration measures provide similar but not completely redundant information.', 'Despite quantitative differences, the overall qualitative pattern of the A-N-, A+N-, A-N+, and A+N+ biomarker group frequency curves by age were similar across the five different definitions of neurodegeneration.', 'We conclude that grouping subjects by amyloidosis and neurodegeneration status (normal/abnormal) is robust to different imaging definitions of neurodegeneration and thus is a useful way for investigators throughout the field to communicate in a common classification framework.'], ["Parkinson's disease (PD) is the second most common neurodegenerative disease among the elderly, and it has been associated with both cognitive and postural abnormalities such as Pisa syndrome (PS)."], ['Several studies describing the ultrastructure and extracellular matrix (ECM) of intervertebral discs (IVDs) involve animal models and specimens obtained from symptomatic individuals during surgery for degenerative disease or scoliosis, which may not necessarily correlate to changes secondary to normal aging in humans.'], ['The fields of neurodegenerative disease and dementia research have grown considerably in the last several decades.', 'Clinician recognition of cognitive impairment has increased considerably, national policies which support screening for and documenting cognitive dysfunction now exist, and public awareness of neurodegenerative disease has never been greater.'], ['It was reported that BP is associated with neurodegenerative diseases (ND).', 'We performed a retrospective study in a setting of a Central European university dermatology department on prevalence of ND in 94 BP patients.', '26 out of 94 BP patients had at least one ND.', "ND included: Parkinson's disease, dementia, stroke, hear loss, tinnitus, blindness, vertigo, neurosyphilis, systemic sclerosis, and epilepsy.", 'Since population aging is conceivably responsible for the rising number of BP cases as a result of immunosenescence-related phenomena, the plausible BP-specific immunopathogenetic relationship between BP and ND deserves to be further experimentally explored.'], ['The Dementias are common neurodegenerative diseases which gradually deteriorate and eventually become fatal.'], ['INTRODUCTION: Osteoarthritis (OA) is a degenerative disease characterized by cartilage degradation and subchondral bone alterations.'], ["Parkinson's disease (PD) is a common neurodegenerative disorder, caused by aging, genetic and environmental factors."], ['Next, we discuss the contribution of CVP to neurodegeneration and use hippocampal volume loss over time in a subset of participants categorized as A-V-, A-V+, A+V-, A+V+.'], ["Although monocytes and macrophages could serve as new therapeutic targets for treatment of Alzheimer's disease (AD) and aging of the human innate immune system, its role in the pathogenesis of neurodegenerative disorders such as AD are only poorly understood."], ["Alzheimer's disease (AD) is one of the most serious progressive neurodegenerative diseases among the elderly, therefore the identification of conversion to AD at the earlier stage has become a crucial issue."], ['Lifestyle improvement appears to be the only sustainable approach to face the dramatic chronic-degenerative disease burden of an aging population.', 'A healthy lifestyle, represented by avoiding smoking, following a healthy diet, and practicing physical activity, protects from chronic-degenerative disease onset and progression.'], ['The cross-sectional and longitudinal assessment of the temporal and spatial patterns of tau deposition in the brain will allow a better understanding of the role tau plays in ageing as well as its relationship with cognition, genotype, and neurodegeneration.'], ["In contrast to the successful modeling of early-onset disorders using patient-specific cells, modeling of late-onset neurodegenerative diseases such as Parkinson's disease remains a challenge.", 'Acknowledging aging as a contributing factor in late-onset neurodegenerative disorders represents an important step on the road towards faithfully recreating these diseases in vitro.'], ['The observed prevalence of pairs of chronic conditions exceeded the expected prevalence for several conditions, such as cardiovascular diseases and metabolic disorders, as well as pulmonary diseases and degenerative disorders.'], ['In particular in age-related diseases like neurodegeneration, a correlation between mitochondrial damage and disease onset has been established.', 'In this review we summarize the current knowledge about mitochondrial protein quality control mechanisms in mammalian cells, with a special emphasis on the role in oxidative stress and in neurodegenerative diseases.'], ['The substantia nigra (SN), the source of major dopaminergic pathways in the brain, is particularly vulnerable to changes in the progression of several age-related neurodegenerative diseases.'], ['A growing body of scientific evidence has shown that phytochemicals possess neuroprotective effects and also mitigate neurodegeneration under both in vivo and in vitro conditions.'], ['Understanding the mechanistic basis for the association of DNA damage and DNA repair with aging and age-related diseases, such as neurodegeneration, would give insight into contravening age-related diseases and promoting a healthy life span.'], ['Degenerative spinal deformity afflicts a significant portion of the elderly and is increasing in prevalence.', 'In this narrative review, we review the recent literature on the epidemiology, evaluation, management, and outcomes of degenerative adult spinal deformity (ASD).'], ['In this article, we review the range of degenerative spinal disorders resulting in progressive cervical spinal cord compression and propose the adoption of a new term, degenerative cervical myelopathy (DCM).'], ['OBJECTIVE: To compare the cost-effectiveness of lumbar decompression with and without fusion for degenerative spine disease in elderly vs nonelderly patients.'], ["In anticipation of the aging of the population, we undertook this project to heighten physicians' awareness of age-related spinal disorders, including geriatric odontoid fractures, central cord syndrome, osteoporotic compression fractures, degenerative cervical myelopathy, lumbar spinal stenosis and degenerative spinal deformity."], ['Narrative review was performed for adult degenerative deformity correction, revealing that MIS techniques are feasible for managing such patients with acceptable rates of osseous union and complication.', 'On the basis of largely low-quality, retrospective evidence, we recommend that elderly patients should not be excluded from MIS interventions for symptomatic lumbar degenerative spinal disease.'], ['Of clinical relevance, Hdacs inhibitors are United States Food and Drug Administration-approved cancer therapeutics and are candidate therapies for other common diseases including arthritis, diabetes, epilepsy, heart disease, HIV infection, neurodegeneration, and numerous aging-related disorders.'], ['Aneuploidy is associated with human diseases including mental retardation, neurodegenerative diseases and cancer.'], ['However, the molecular mechanisms by which the truncated tau fragment causes neurodegeneration remain unknown.', 'Our results suggest that Tau-CTF24 contributes to neurodegeneration by enhancing prion-like propagation as well as deteriorating the mechanisms involved in microtubule function.'], ['The accumulation of MG indiscriminately modifies proteins, including important cellular antioxidant machinery, leading to severe oxidative stress, which is implicated in multiple neurodegenerative disorders, aging, and cardiac disorders.'], ["BACKGROUND: Parkinson's disease (PD) is a common neurodegenerative disease affecting the quality of life in the elderly."], ["Parkinson's disease (PD) is a common chronic neurodegenerative disorder associated with aging that primarily caused by the death of dopaminergic neurons in the substantia nigra pars compacta (SN)."], ['Both genome instability and micronutrient imbalance have been identified and implicated in diseases associated with accelerated ageing which potentially leads to an increased risk for the future development of clinically defined neurodegenerative disorders.', 'Currently, there is a need for preventative strategies as well as the identification of robust and reproducible diagnostic biomarkers that will allow identification of those individuals with increased risk for neurodegenerative diseases.', 'Growing evidence suggests cells originating from different somatic tissues derived from individuals that have been clinically diagnosed with neurodegenerative disorders exhibit elevated frequencies of DNA damage compared to tissues of cognitively normal individuals which could be due to malnutrition.'], ["Alzheimer's disease (AD) is a neurodegenerative disease which has a higher prevalence and incidence in older people."], ['In aging humans and/or rodents, NAC supplementation has exerted favorable effects on vascular health, muscle strength, bone density, cell-mediated immunity, markers of systemic inflammation, preservation of cognitive function, progression of neurodegeneration, and the clinical course of influenza-effects which could be expected to lessen mortality and stave off frailty.'], ['Aging is a major risk factor for a number of neurodegenerative disorders.', 'Herein, we also review the available literature regarding the chemistry of luteolin, its herbal sources, and bioavailability as a pharmacological agent for the treatment and management of age-related neurodegenerative disorders.'], ['Our results suggest that genetic variants in genes on 19q13, some of which are involved in brain development and neurodegeneration, may influence the susceptibility to psychosis in LOAD patients.'], ['Impaired mitochondrial maintenance is causally linked to many human pathologies and aging, including diabetes, cancer, and neurodegenerative diseases.'], ['Our findings reveal that the accumulation of this aberrant glycogen accounts for the neurodegeneration and functional consequences, as well as the impaired autophagy, observed in models of this disease.', 'Our findings change the current view of the role of glycogen in the brain and reveal that endogenous neuronal glycogen metabolism is important under stress conditions and that neuronal glycogen accumulation contributes to neurodegenerative diseases and to aging-related corpora amylacea formation.'], ['Due to the aging of society, the number of people who will likely need medical intervention at a time when they will be incapable of making decisions has been increasing, especially within neurodegenerative diseases.'], ["Patterns of EPS in AD show distinct clinical and neuropathological correlates; they share a pattern of presentation similar to that seen in Parkinson's disease, suggesting common pathogenic mechanisms across neurodegenerative diseases."], ['IMPORTANCE: Human episodic memory performance is linked to the function of specific brain regions, including the hippocampus; declines as a result of increasing age; and is markedly disturbed in Alzheimer disease (AD), an age-associated neurodegenerative disorder that primarily affects the hippocampus.'], ["Alzheimer's disease (AD) is the most common neurodegenerative disorder of the brain."], ['Psychiatric symptoms with atypical features (e.g., late-life onset, insidiously worsening course) should prompt careful assessment for neurodegenerative disease.'], ['We then highlight the contribution of FDG-PET to the understanding of the patterns of functional differences in non-degenerative pathologies, normal ageing, and age-related neurodegenerative disorders.'], ['Here, we study FUS, a prion-like protein containing intrinsically disordered domains associated with the neurodegenerative disease ALS.'], ['p25/Cyclin-dependent kinase 5 (Cdk5) has been implicated in the pathogenesis of several neurodegenerative diseases, including AD.'], ['This chapter discusses recent progress in understanding how proteomic profiling of patient samples derived from the central nervous system can elucidate the DPM biology of human neurodegenerative diseases.'], ['Neurodegenerative diseases are a major health concern worldwide.', 'Presymptomatic diagnosis of neurodegenerative disorders is challenging due to the lack of robust biomarkers.', 'Likewise, the design of effective intervention strategies is limited because most neurodegenerative disorders are heterogeneous in nature.', 'Recent biological and technological advances within the field of proteomic promises to provide insight into global proteome changes in neurodegeneration, thus allowing increased understanding of molecular pathways leading to neuronal cell death and the identification of biomarkers.', 'The application of comparative high-throughput proteomic analyses in animal models and human tissues will aid in the identification of both diagnostic and prognostic biomarkers and will provide a platform for a future personalized medicine approach in neurodegeneration.'], ['These findings could provide new clues for unveiling mechanisms underlying iron-related neurodegenerative diseases.'], ['BACKGROUND: Population aging is a global phenomenon whose main consequence is the increase of chronic degenerative diseases, including dementia.'], ["Late-onset Alzheimer's disease (AD) is an irreversible neurodegenerative disease of the elderly characterized by amyloid beta (Abeta) plaques and neurofibrillary tangles."], ["Alzheimer's disease (AD) is the leading cause of dementia and the most common neurodegenerative disease in the elderly.", 'Furthermore, AD has provided the most positive indication to support the fact that inflammation contributes to neurodegenerative disease.'], ["Alzheimer's disease (AD) is a neurodegenerative disorder characterized by fibrillary aggregates of Abeta peptide and tau protein."], ['Changes in signalling in astrocytes, as well as in neurons, may be important in ageing and neurodegeneration.'], ['Alzheimer disease (AD) is one of the most common neurodegenerative disorders widely occurring among the elderly.'], ["BACKGROUND: Alzheimer's disease (AD) is an inexorable neurodegenerative disease that commonly occurs in the elderly."], ['BACKGROUND: Microglia are involved in immune surveillance in intact brains and become activated in response to inflammation and neurodegeneration.'], ["BACKGROUND: Alzheimer's disease (AD), the most common form of dementia in the elderly, is a neurodegenerative disorder associated with a complex pathophysiology."], ['Structural MRI is widely used for investigating brain atrophy in many neurodegenerative disorders, with several research groups developing and publishing techniques to provide quantitative assessments of this longitudinal change.'], ['Isthmic spondylolisthesis treated using total laminectomy or degenerative spondylolisthesis treated using subtotal laminectomy and interbody fusion (IBF) or posterolateral fusion (PLF) were also included in the risk factor analysis.'], ["Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the most common type of dementia among older people."], ["Older adult apolipoprotein-E epsilon 4 (APOE-epsilon4) allele carriers vary considerably in the expression of clinical symptoms of Alzheimer's disease (AD), suggesting that lifestyle or other factors may offer protection from AD-related neurodegeneration.", 'Rather, we hypothesize that PA may protect APOE-epsilon4 allele carriers from selective neurodegeneration of individual fiber populations at locations of crossing fibers within projection and association WM fiber tracts.'], ['The trajectory, or slope, of cognitive decline may provide differentiation of older adults with and without incipient neurodegenerative disease.'], ['Data from non-neuronal cell models and/or models using heterologous expression of FUS mutants suggest cytoplasmic FUS translocation as a pivotal initial event which leads to neurodegeneration depending on a second hit.', 'Finally, neurodegeneration was not specific to layer V cortical neurons perfectly in line with the current model of disease spreading in ALS.'], ['While aberrant endosomal protein sorting has been linked to several neurodegenerative diseases, the mechanisms by which VPS35 mutations and retromer function contribute to PD pathogenesis are not clear.'], ['Their ability to self-renew and differentiate into several lineages makes them a promising tool for cell-based therapies in different types of degenerative diseases.'], ['Circulating amylin oligomers that cross the blood-brain barrier and accumulate in the brain may be an important contributor to diabetic cerebral injury and neurodegeneration.'], ["Alzheimer's disease (AD) is known to be a multifactorial neurodegenerative disorder, and is one of the main causes of dementia in the elderly."], ["MicroRNAs (miRNAs) are emerging as significant regulators of mRNA complexity in the human central nervous system (CNS) thereby controlling distinct gene expression profiles in a spatio-temporal manner during development, neuronal plasticity, aging and (age-related) neurodegeneration, including Alzheimer's disease (AD)."], ["Today, a 're-invention' of its use in fundamental and applied research is paving the way for a better understanding of the mechanisms causing neurodegeneration.", 'The increasing emergence of neurodegenerative disorders is becoming more and more problematic in our ageing society.', 'Despite the huge importance of thoroughly understanding the underlying molecular mechanisms of neurodegeneration, progress has been slow.', 'However, multiple complementary research methods are proving their value, particularly with the work done with S. cerevisiae, which combines well-established, fast genetic and molecular techniques with the ability to faithfully capture key molecular aspects of neurodegeneration.'], ['Longitudinal normative data obtained from a robust elderly sample (i.e., believed to be free from neurodegenerative disease) are sparse.'], ['Participants met strict inclusion criteria for the absence of any active or past neurodegenerative disorders.', 'Thus, it has the ability to differentiate functional dependence due to age-related decline from neurodegenerative disease.'], ['OBJECTIVE: The aim of this study was to investigate the prevalence of olfactory dysfunction and evaluate the relationship between olfactory function and nutritional status, comorbidity, and the results of a neurocognitive test in geriatric patients who do not suffer from neurodegenerative disease.'], ['Dysfunction in the autophagy pathway is associated with several human diseases, from infectious diseases to cancer and neurodegeneration.'], ['It is of critical concern that persistent hyperactivation of mTORC1 is associated with aging and the development of age-related disorders such as obesity, type 2 diabetes mellitus, cancer, and neurodegenerative diseases.'], ['We anticipate that age and sex are important co-factors to take into account when establishing a baseline level for differentiating pathologic neurodegeneration from healthy aging.'], ['Mitochondrial dysfunction has been linked to neurodegenerative diseases, cancer and ageing.'], ['Neurodegenerative diseases are often associated with both normal and premature aging.', 'Cell cycle and DNA replication proteins are frequently found in patients with neurodegenerative diseases.', 'Oxidative stress, which is considered to play an important role in aging and pathogenesis of many neurodegenerative diseases, can induce DNA damage and stimulate cell cycle re-entry by neuronal cells.', "There is also evidence to suggest that cytostatic chemotherapy could decrease dementia in Alzheimer's disease and multiple myeloma, supporting the use of cell cycle inhibitors in the therapy of degenerative diseases."], ['Alteration of DNA methylation is highly associated with aging and neurodegenerative disorders, such as amyotrophic lateral sclerosis (ALS).'], ["INTRODUCTION: Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by the loss of dopaminergic neurons as well as the presence of proteinaceous inclusions named Lewy bodies.", 'In this study, we developed and exploited a recombinant adeno-associated viral (AAV) vector of serotype 9 overexpressing mutated alpha-syn to elucidate the influence of ageing on the dynamics of PD-related neurodegeneration associated with alpha-syn pathology in different mammalian species.', 'RESULTS: Identical AAV pseudotype 2/9 vectors carrying the DNA for human mutant p.A53T alpha-syn were injected into the substantia nigra to induce neurodegeneration and synucleinopathy in mice, rats and monkeys.', 'Unlike mice, monkeys did not exhibit correlations between levels of phosphorylated alpha-syn and neurodegeneration.', 'CONCLUSIONS: In conclusion, AAV2/9-mediated halpha-syn induces robust nigrostriatal neurodegeneration in mice, rats and monkeys, allowing translational comparisons among species.', 'Ageing, however, neither exacerbated nigrostriatal neurodegeneration nor alpha-syn pathology per se.'], ['UNLABELLED: In an increasingly aged population, sleep disturbances and neurodegenerative disorders have become a major public health concern.'], ['Cognitive impairment (CI) can develop during the course of ageing and is a feature of many neurological and neurodegenerative diseases.', 'We discuss pain responding across a large number of neurological and neurodegenerative disorders in which CI is typically present.'], ['CONCLUSIONS: Our findings suggest that inflammation in the CNS increases in normal aging and is intimately related to markers of neurodegeneration in the preclinical stages of AD and SNAP.'], ['Given the concurrent, escalating epidemic of diabetes mellitus and neurodegenerative diseases, two age-related disorders, we aimed to understand the relation between parameters of glucose metabolism and indices of pathology in the aging brain.'], ['Finally, the molecular mechanisms shared among all dementia types including hypoxia, oxidative stress, mitochondrial bioenergetics, neuroinflammation, neurodegeneration, and blood-brain barrier permeability responsible for disease etiology and progression will be discussed.'], ['Univariate and multivariate logistic analyses were performed to identify relationships between factors [age, sex, neurological condition, concomitant disease, American Society of Anesthesiology (ASA) classification, preoperative Karnofsky Performance Scale (KPS) score, tumor location and size, peritumoral edema, and Simpson resection grade] and outcome.'], ['Parkin biology has emerged as an exciting area of pharmaceutical development for several human diseases, including cancer and neurodegeneration.'], ['Autophagy dysfunction was found in aged and neurodegenerative brains.'], ['Aging drives cognitive and regenerative impairments in the adult brain, increasing susceptibility to neurodegenerative disorders in healthy individuals.'], ["Secretion of VGF is increased in cerebrospinal fluid and blood in neurodegenerative disorders like Alzheimer's disease (AD) and VGF is a potential biomarker for these disorders."], ['We focus on diseases arising from age-driven impairment in energy metabolism (obesity, diabetes), the declining capacity to respond homeostatically to proliferative and damaging stimuli (cancer, immune dysfunction), and neurodegeneration.'], ['Yet, in the purely therapeutic sense, there is a distinct clinical and practical separation between age-related degenerative diseases and the background process of aging itself.', 'It is quite possible that biomedical technologies will prove invaluable in treating or alleviating the impact of distinct age-related degenerative diseases such as cardiovascular disease, arthritis or dementia.'], ['Both can be affected by normal aging, neurodegenerative disorder, and brain injury, and there is an increasing interest in studying street-crossing decisions.'], ['BACKGROUND: The aging process promotes a progressive increase in chronic-degenerative diseases.'], ['The underlying mechanisms by which these hormones modulate Abeta accumulation and contribute to neurodegeneration are not completely understood, however they have been shown to regulate Abeta metabolism, enhance its clearance and alter the processing of its parent molecule, the amyloid precursor protein.'], ['We contend that coevolution of Nrf2-activating secondary metabolites by fungi and other extant microbiota may provide prospective compound leads for the design of new therapeutics to target activation of the human Keap1-Nrf2 pathway for treating degenerative diseases of ageing.'], ['Thus, increased zinc in the complex milieu of the ageing and AD brain could reduce the level of normal full-length ApoE and increase other forms that are involved in neurodegeneration.'], ['The recent discovery of 5-hydroxymethylcytosine (5hmC), an epigenetic modifier and oxidation product of 5-methylcytosine (5mC), has broadened the scope and understanding of neural development and neurodegenerative diseases.', 'Although DNA methylation plays an important role in normal neural development and neuroprotection, an altered pathway due to complex interaction with environmental and genetic factors may cause severe neurodegeneration.', 'The levels of 5hmC in brain increase progressively from birth until death, while in patients with neurodegenerative disorders, the levels are found to be highly compromised.', "This article discusses the recent developments in the area of hydroxymethylation, with particular emphasis on the role of 5hmC in neurodegenerative diseases including Alzheimer's disease, Parkinson's diseases and Huntington's disease.", 'Despite compelling evidence on the involvement of 5hmC in neurodegeneration, it is yet to be established whether this epigenetic molecule is the cause or the effect of the onset and progression of neurodegenerative diseases.'], ['Accordingly, the prevalence of chronic and degenerative diseases will increase, among them osteoarthritis, resulting in more and older patients undergoing total joint arthroplasty and thereby also being at risk for associated complications.'], ["Alzheimer's disease (AD) is a progressive neurodegenerative disorder and is the most common form of dementia among the aging population.", 'Micro (mi) RNAs (miR) have gained increasing attention in the investigation of neurodegenerative diseases.'], ['Given the importance of protein ubiquitination in proteome homeostasis of aging brains and neurodegenerative disorders, our finding suggests the significance of epigenetic regulation of this posttranslational modification pathway in the aging brain.'], ['Dysfunction of the proteasome is associated with aging processes and human diseases such as neurodegeneration, cardiomyopathy, and cancer.'], ['METHODS: We devised the Mediterranean-Dietary Approach to Systolic Hypertension (DASH) diet intervention for neurodegenerative delay (MIND) diet score that specifically captures dietary components shown to be neuroprotective and related it to change in cognition over an average 4.7 years among 960 participants of the Memory and Aging Project.'], ['DWI thermometry can thus be used to help to explore the pathophysiology of Parkinsonian syndromes and to differentiate individuals affected by neurodegenerative disease with autonomic dysfunction from those without it.'], ['The aim of this study was to develop a method to quantify CSF particles and evaluate their relationship to aging and neurodegenerative diseases.', 'Our approach provides new methods to investigate CNS lipid biology in relation to neurodegeneration and perhaps develop new biomarkers for diagnosis or treatment monitoring.'], ['Hippocampal sclerosis of aging (HS-Aging) is a neurodegenerative disease that mimics Alzheimer disease (AD) clinically and has a prevalence rivaling AD in advanced age.'], ['LMNA gene mutations are associated with a variety of degenerative diseases and devastating premature aging syndromes such as Hutchinson-Gilford Progeria Syndrome (HGPS) and Restrictive Dermopathy (RD).'], ['Aged dogs are considered the most suitable spontaneous animal model for studying normal aging and neurodegenerative diseases.', 'Further studies on the canine model are needed to clarify the role of age-related changes in UPS activity and HSP expression in neurodegeneration in order to design novel treatment strategies, such as HSP-based therapies, aimed at improving chaperone defences against proteotoxic stress affecting brain during aging.'], ["CSF biomarkers are largely consistent with disease trajectories predicted by beta-amyloid cascade (Hardy, J Alzheimer's Dis 2006;9(Suppl 3):151-3) and tau-mediated neurodegeneration hypotheses for AD, whereas brain atrophy and hypometabolism levels show predicted patterns but exhibit differing rates of change depending on region and disease severity; (3) the assessment of alternative methods of diagnostic categorization."], ['Genes that increase oxidative stress, or are linked to cardiac hypertrophy or neurodegenerative diseases in mammals also affect cardiac ageing in the fruit fly.'], ['The specific signaling mechanisms underpinning neurodegeneration and aging are incompletely understood.', 'Much work has been directed to the search for the etiology of neurodegeneration and aging and to new therapeutic strategies, including not only drugs but also non-pharmacological approaches, such as physical exercise and low-calorie dietary intake.'], ['Neurodegenerative diseases often have prodromal periods of decades in which regional neuronal cell loss occurs prior to clinical presentation.', 'This current study in cognitively normal aging individuals provides the basis for the pursuance of investigations directed towards such neurodegenerative diseases.'], ['BACKGROUND: Oxidative stress is involved in neuronal cell death and mitochondrial dysfunction in neurodegenerative diseases.', 'Therefore, LPE has potential anti-apoptotic effects that may be neuroprotective in neurodegenerative diseases and aging-related dementia.'], ['Using glaucomatous optic neuropathy as an exemplar for neurodegeneration, this study investigates putative factors imparting resistance to neurodegeneration.', 'While it has been known for some years that mitochondrial dysfunction is implicated in neurodegeneration, this study provides a fresh perspective to the field of neurodegeneration by providing, for the first time, evidence that systemic mitochondrial efficiency above normal healthy levels is associated with an enhanced ability to withstand optic nerve injury.', 'These results demonstrate the importance of cellular bioenergetics in glaucomatous disease progression, with potential relevance for other neurodegenerative disorders, and raise the possibility for new therapeutic targets in the field of neurodegeneration.'], ['Anti-aging medicine-oriented groups have intervened on the market with products working on telomerase activation for a broad range of degenerative diseases in which replicative senescence or telomere dysfunction may play an important role.'], ["INTRODUCTION: Neurodegenerative disease diagnoses may be supported by the comparison of an individual patient's brain magnetic resonance image (MRI) with a voxel-based atlas of normal brain MRI.", 'Nonparametric methods are advisable when studying the limits of brain structure in ageing and neurodegenerative disease.'], ['AAV transfection technique was able to highly and stably express TB-4 in human NP cells, which may provide a new pathway for innovation in the treatment of intervertebral disc degenerative diseases.'], ['With ever-increasing elder population, the high incidence of age-related diseases such as neurodegenerative disorders has turned out to be a huge public concern.', 'That indicates the impairment of DNA methylation may be a crucial but reversible mechanism of behavioral and cognitive related neurodegeneration.'], ['It has been demonstrated that both these neurodegenerative diseases are associated with smell dysfunction.', "RESULTS/CONCLUSIONS: Alzheimer's and Parkinson's diseases are both neurodegenerative disorders typically found in the elderly."], ['In the absence of a single preventive or disease-modifying strategy, neurodegenerative diseases are becoming increasingly prevalent in our ageing population.', 'The mechanisms underlying neurodegeneration are poorly understood, making the target-based drug screening strategies that are employed by the pharmaceutical industry fraught with difficulty.'], ['These findings have implications for the understanding of local sleep regulation and conditions such as ageing, depression, and neurodegeneration which are associated with changes in SWs, neural plasticity and circadian rhythmicity.'], ['Genes that are differentially regulated during cellular senescence refer to pathways involved in neurodegeneration, focal adhesion, actin cytoskeleton, proteasome, cell cycle, DNA replication, and oxidative phosphorylation.'], ['OBJECTIVE: Peroxisome proliferator activated receptor gamma-activating drugs show various salutary effects in preclinical models of neurodegenerative disease.'], ['Impaired or dysregulated function of mitoproteases is associated with ageing and with many pathological conditions such as neurodegenerative disorders, metabolic syndromes and cancer.'], ['Cerebrospinal fluid (CSF) alpha-synuclein (ASYN) levels are emerging as a possible biomarker in a number of neurodegenerative conditions; however, there has been little study of such levels in demyelinating conditions with neurodegeneration such as multiple sclerosis (MS).', 'Our results suggest that in a cohort of CIS and MS patients, CSF ASYN levels are decreased, thus providing another possible link between MS and neurodegeneration.', 'We find a similar magnitude of decreased alpha-synuclein compared to a control group in all such MS spectrum conditions; such a decrease may reflect an underlying early neurodegenerative disease process.'], ['In mammalian tissues a deficit of these mechanisms is commonly associated with cellular aging and degenerative diseases related to aging, such as cardiovascular disease, cancer, immune system decline, and neurological pathologies.'], ['Nowadays, it has been clearly demonstrated that Apo D expression is induced and its subcellular location undergoes modifications in stressful and pathological conditions that characterize aging processes and neurodegenerative diseases.', 'In addition, we demonstrated that Apo D tends to accumulate around the nuclear envelope in neurons and glial cells of different brain areas in some neurodegenerative diseases and during human aging, but never inside the nucleus.'], ['Our results indicate that combined physical and cognitive training shows indices of a positive neuroplastic effect in MCI patients and that EEG may serve as a potential index of gains versus cognitive declines and neurodegeneration.'], ['OBJECTIVES: Our objective was to investigate cross-sectional associations between odor identification ability and imaging biomarkers of neurodegeneration and amyloid deposition in clinically normal (CN) elderly individuals, specifically testing the hypothesis that there may be an interaction between amyloid deposition and neurodegeneration in predicting odor identification dysfunction.', 'CONCLUSIONS: In CN elderly, worse odor identification was associated with markers of neurodegeneration.'], ['Baill, has been traditionally used in management of liver diseases and ageing associated neurodegeneration.', 'CONCLUSION: These findings demonstrate that schisantherin A may have potential therapeutic value for neurodegenerative diseases associated with abnormal oxidative stress such as Parkinson s disease.'], ["INTRODUCTION: Alzheimer's disease (AD) is a neurodegenerative disorder characterized by memory loss and personality changes, leading to dementia."], ['INNOVATION: These findings showed for the first time that arginine 213 in the HBD of SOD3 is critical for maintaining proper organ function through moderating the normal innate immune response, which would otherwise lead to chronic inflammation and degenerative diseases in aged mice.'], ['The accumulation of non-heme iron in the brain has been proposed as a harbinger of neural and cognitive decline in aging and neurodegenerative disease, but support for this proposal has been drawn from cross-sectional studies, which do not provide valid estimates of change.'], ['Here, we review the signaling cascades and molecular mechanisms that govern the process of mitophagy and discuss their involvement in ageing and neurodegeneration.'], ['These trends are accompanied by an epidemiological transition towards non-communicable diseases, mental disorders and degenerative diseases as the leading causes of mortality and morbidity in lieu of communicable diseases.'], ['Human aging involves a gradual decrease in cellular integrity that contributes to multiple complex disorders such as neurodegenerative disorders, cancer, diabetes, and cardiovascular diseases.'], ["The failure of neurons to keep optimal intracellular Ca2+ concentrations is a common feature of neurodegeneration by aging and aging-linked neuropathologies, such as Alzheimer's disease (AD).", 'These results point out a link between Ca2+-transporters, aging and neurodegeneration mediated by tau protein.'], ["CONCLUSION: Degenerative diseases like dementia and Parkinson's disease as well as strokes and headaches are frequently encountered neurological diseases in elderly patients in Sub-Saharan Africa."], ["Parkinson's disease (PD) is the second most common neurodegenerative disorder in the elderly people, currently with no cure.", 'We demonstrated that dietary supplementation of the worms with an extract from the cultivated red seaweed Chondrus crispus decreased the accumulation of alpha-synulein and protected the worms from the neuronal toxin-, 6-OHDA, induced dopaminergic neurodegeneration.'], ['However, little is known regarding network organisation of the healthy elderly connectome, a crucial prelude to the systematic study of neurodegenerative disorders.', "These findings provide insights into healthy brain ageing and provide a benchmark for the study of neurodegenerative disorders such as Alzheimer's disease (AD) and frontotemporal dementia (FTD)."], ['Cerebrospinal fluid (CSF) markers of neuronal injury or neurodegeneration may offer usefulness in predicting disease progression and guiding outcome assessments and prognostic decisions in clinical trials of disease-modifying therapies.', 'CONCLUSIONS AND RELEVANCE: Cerebrospinal fluid VILIP-1 levels predict rates of whole-brain and regional atrophy similarly to tau and p-tau181 and may provide a useful CSF biomarker surrogate for neurodegeneration in early symptomatic and preclinical AD.'], ['Understanding age-related network changes may provide solutions for the impact of population aging and diagnosis of neurodegenerative diseases.'], ["Neurodegeneration due to Alzheimer's disease (AD) can progress over decades before dementia becomes apparent.", 'Based on the schema of a well-received model of biomarker dynamics in AD pathogenesis, it has been postulated that SCD symptoms may result from compensatory changes in response to beta-amyloid accumulation and neurodegeneration.'], ['Moreover, the degree of chaperone decline corresponds with the severity of neurodegeneration.', "Finally, we demonstrated that a sustained increase of GRP78 protein over the course of 9 months protected aging nigral DA neurons in the alpha-syn-induced rat model of Parkinson's-like neurodegeneration.", 'Our data indicate that the ER chaperone GRP78 may have therapeutic potential for preventing and/or slowing age-related neurodegeneration.'], ['Knee osteoarthritis (OA) is a highly prevalent chronic degenerative joint disease that mainly affects the elderly population.'], ['It has been suggested that mitochondria play dynamic roles in regulating synaptogenesis and morphological/functional responses of synaptic activity, and thus, deteriorating of mitochondrial function (e.g., deficits of the mitochondrial respiratory enzymes, reduced calcium influx, increased accumulation of mitochondrial DNA defects/apoptotic proteins and impairment of mitochondrial membrane potential) can lead to severe neuronal energy deficit, and in the long run, to modifications in neuronal synapses and neurodegeneration in the ageing brain.', 'Hence, considering the mechanisms by which mitochondrial impairment can lead to neuronal death, the development of neuroprotective molecules that target various mitochondrial pathogenic processes can be effective in the treatment of ageing and age-related neurodegenerative diseases.'], ['Future studies are needed to determine the extent to which this marker of neuroplasticity is sustained over a longer period of time, and is influenced by age, cognitive status, and neurodegenerative disease.'], ["Alzheimer's disease (AD), the most common form of dementia, is a chronic, progressive neurodegenerative disease that manifests clinically as a slow global decline in cognitive function, including deterioration of memory, reasoning, abstraction, language and emotional stability, culminating in a patient with end-stage disease, totally dependent on custodial care."], ['Genes showing increased mRNA/protein disparity in primate brain aging form expression patterns conserved between humans and macaques and are enriched in specific functions involving mammalian target of rapamycin (mTOR) signaling, mitochondrial function and neurodegeneration.'], ['Autophagy was known to be associated with aging in addition to cancer and neurodegeneration.'], ['Exercise is a uniquely effective and pluripotent medicine against several noncommunicable diseases of westernised lifestyles, including protection against neurodegenerative disorders.'], ['Among those with more advanced age, higher pulse pressure was also associated with cerebral amyloidosis in the presence of neurodegeneration and more rapid progression to dementia.'], ["Alzheimer's disease (AD) is the most common neurodegenerative disorder and there is currently no efficient cure for this devastating disease."], ['Mutations in human mitochondrial DNA (mtDNA) can cause mitochondrial disease and have been associated with neurodegenerative disorders, cancer, diabetes and aging.'], ['These neuropathological features and aberrant brain microRNA (miRNA) expression patterns have been implicated in the etiopathogeneses of various neurodevelopmental and aging-related neurodegenerative disorders.'], ['Its aberrant expression has been linked to cancer, neurodegeneration, neuropsychiatric disorders and primary hypogonadism.', 'Reduced levels of these steroids have been linked to depression, anxiety and neurodegeneration.'], ['As models of preceding axonal degeneration, both the tumor necrosis factor (TNF) injection model and hypertensive glaucoma model may be useful in understanding the mechanism of axonal degeneration of RGCs, and the concept of axonal protection can be an attractive approach to the prevention of neurodegenerative optic nerve disease.', 'Like other neurodegenerative diseases, optic nerve degeneration may exhibit autophagic flux impairment resulting from elevated intraocular pressure, TNF, traumatic injury, ischemia, oxidative stress, and aging.'], ['Neurodegeneration is one of the hallmarks of AD, which consequently induces cognitive impairment.'], ['Translational research for neurodegenerative disease depends intimately upon animal models.', 'Unfortunately, promising therapies developed using mouse models mostly fail in clinical trials, highlighting uncertainty about how well mouse models mimic human neurodegenerative disease at the molecular level.', 'We compared the transcriptional signature of neurodegeneration in mouse models of Alzheimer s disease (AD), Parkinson s disease (PD), Huntington s disease (HD) and amyotrophic lateral sclerosis (ALS) to human disease.', 'Spearman s correlation analysis revealed even healthy human aging to be more closely related to human neurodegeneration than any mouse model of AD, PD, ALS or HD.', 'Among potential alternate models of neurodegeneration, mouse prion disease outperformed all other disease-specific models.', 'These findings suggest a more complex and multifactorial pathophysiology in human neurodegeneration than is captured through standard animal models, and suggest that even among conserved physiological processes such as aging, mice are less prone to exhibit neurodegeneration-like changes.', 'This work may help explain the poor track record of mouse-based translational therapies for neurodegeneration and provides a path forward to critically evaluate and improve animal models of human disease.'], ['Thus, neuromelanin appears to serve as a natural contrast agent for nucleus LC that can be used to localize nucleus LC and may have the potential to characterize neurodegenerative disease.'], ['Protein dishomeostasis, aberrant protein folding, and protein aggregation are indeed involved in several diseases including cancer, aging-associated, and neurodegenerative disorders.'], ['Inflammation in the aging brain increases risk for neurodegenerative disease.', 'Chronic peripheral administration of lipopolysaccharide in the RGS10-null mice induces nigral dopaminergic (DA) degeneration, suggesting that RGS10 modulates neuroimmune interactions and may influence susceptibility to neurodegeneration.', 'Because age is the strongest risk factor for neurodegenerative disease, we assessed whether RGS10 expression changes with age and whether aged RGS10-null mice have altered immune cell profiles.'], ["The above findings suggest a novel mechanism for polyphenols' neuroprotective effect in neurodegeneration and galangin as a potential drug candidate for AD therapy."], ['Intervertebral disc (IVD) degeneration is a common degenerative disease, yet much is unknown about the mechanisms during its pathogenesis.', 'Taken together, PGRN may play a critical role in homeostasis of IVD, and may serve as a potential molecular target for prevention and treatment of disc degenerative diseases.'], ['We show that restoration of Kv4 attenuated age-dependent learning and locomotor deficits, slowed the onset of neurodegeneration, and partially rescued premature death seen in Abeta42-expressing animals.'], ['Following an overview of the most relevant evidence for the benefit of DR on neurodegenerative disorders and brain aging and damage in animals and human beings, the article will address the major mechanisms currently believed to participate in these effects, at a tissue (antiinflammation, enhanced adult neurogenesis and neuronal plasticity) and cellular (autophagy and mitochondrial biogenesis) level.'], ['A better understanding of the pathological mechanisms that drive neurodegeneration in individuals with multiple sclerosis is needed to develop therapies that will effectively treat patients in the primary and secondary progressive stages of the disease.', 'We propose that the inflammatory demyelinating disease process in early multiple sclerosis triggers a cascade of events that lead to neurodegeneration and are amplified by pathogenic mechanisms related to brain ageing and accumulated disease burden.', 'Key elements driving neurodegeneration include microglia activation, chronic oxidative injury, accumulation of mitochondrial damage in axons, and age-related iron accumulation in the human brain.'], ['Rhythmic brain activity at low frequencies (<12Hz) during rest are thought to increase in neurodegenerative disease, but findings in healthy neurocognitive aging are mixed.'], ['BACKGROUND AND AIMS: Heat shock proteins (HSPs) have been regarded as cytoprotectants that protect brain cells during the progression of neurodegenerative diseases and from damage resulting from cerebral ischemia.'], ['Misfolded protein aggregates are the hallmark of several neurodegenerative diseases in humans.', 'The main protein constituent of these aggregates and the regions within the brain that are affected differ from one neurodegenerative disorder to another.'], ['Accumulation of dysfunctional mitochondria is observed in ageing and many human diseases such as cancer and various neurodegenerative disorders.'], ['Vascular endothelial growth factor (VEGF) has been implicated in staving off AD-related neurodegeneration.'], ["The major discussion topics included: (1) the biology of tendon stem/progenitor cells (TSPCs) and the potential of stem cell-based tendon therapy using TSPCs and other types of stem cells, namely, embryonic and/or induced pluripotent stem cells (iPSCs), (2) the biological concept and potential impact of cellular senescence on tendon aging, tendon injury repair and the development of degenerative disease, and (3) the effects of tendon cells' mechano-response on tendon cell fate and metabolism."], ['The rate of inflammation increases in elderly individuals, a phenomenon called inflammaging, and is associated with degenerative diseases.'], ['We consider the regression or retrogenesis hypothesis, which argues that order of acquisition in development is reversed in neurodegeneration or pathology.'], ['DS is also a unique genetic system for investigation of pathological and protective mechanisms for accelerated ageing, neurodegeneration, dementia, cancer, and other important common diseases.', 'Our fully isogenic system therefore opens possibilities for modeling mechanisms of developmental, accelerated ageing, and neurodegenerative pathologies caused by T21.'], ["Alzheimer's disease (AD) is a common neurodegenerative disease affecting cognitive function in the elderly, which is characterized by the presence of extracellular deposits of insoluble amyloid-beta plaques and neuronal loss."], ['Our results warrant further investigation in independent and larger cohorts and add to the growing understanding of the genetics and pathobiology of depressive symptoms in aging and neurodegenerative disorders.'], ["Alzheimer's disease (AD) is an irreversible and progressive neurodegenerative disorder."], ['Nucleotide insertions in the last exon of the ferritin light chain cause a neurodegenerative disease known as Neuroferritinopathy, characterized by iron deposition in the brain, particularly in the cerebellum, basal ganglia and motor cortex.'], ['Classically AD has been viewed as a neurodegenerative disease of the elderly, characterized by the extracellular deposition of misfolded amyloid-beta (Abeta) peptide and the intracellular formation of neurofibrillary tangles.'], ['Membrane phospholipids make up a substantial portion of the human brain, and changes in their amount and composition are thought to play a role in the pathogenesis of age-related neurodegenerative disease.'], ['Aging is the principal demographic risk factor for Alzheimer disease (AD), the most common neurodegenerative disorder.', 'Whether klotho can counteract deficits related to neurodegenerative diseases, such as AD, is unknown.'], ['For some glutathione transferase genes there is also a correlation between polymorphisms and onset/outcome of neurodegenerative diseases.', 'Thus, there is a general agreement about the protective effect exerted by glutathione and glutathione transferases but no clear answer about the mechanisms underlying this crucial role in the insurgence of neurodegenerative diseases.'], ['These findings have implications for treating specific diseases, including neurodegeneration and cancer, as well as targeting aging in general.'], ['Major targets are to enhance clearance and to reduce cerebral accumulation of amyloid, decrease hyperphosphorylation of tau and the generation of neurofibrillary tangles, reduce inflammation, and finally progressive neurodegeneration.'], ["INTRODUCTION: Proposed diagnostic criteria (international working group and National Institute on Aging and Alzheimer's Association) for Alzheimer's disease (AD) include markers of amyloidosis (abnormal cerebrospinal fluid [CSF] amyloid beta [Abeta]42) and neurodegeneration (hippocampal atrophy, temporo-parietal hypometabolism on [18F]-fluorodeoxyglucose-positron emission tomography (FDG-PET), and abnormal CSF tau).", 'DISCUSSION: The best criteria combined amyloidosis and neurodegeneration biomarkers, whereas the individual biomarker with the best performance was FDG-PET.'], ["Environmental and genetic factors are likely to be involved in the pathogenesis of Parkinson's disease (PD), the second most prevalent neurodegenerative disease among the elderly."], ['BACKGROUND: A reduction in key antioxidants such as glutathione has been noted in brain tissue undergoing oxidative stress in aging and neurodegeneration.'], ["Parkinson's disease (PD) is an insidious and incurable neurodegenerative disease, and represents a significant cost to individuals, carers, and ageing societies."], ['BACKGROUND: Dementia with Lewy bodies (DLB) is a common cause of neurodegenerative dementia of old age.'], ['Hippocampal atrophy is observed with ageing and age-related neurodegenerative disease.', 'Identification of the genetic correlates of hippocampal volume (HV) and atrophy may assist in elucidating the mechanisms of ageing and age-related neurodegeneration.'], ['The results suggest that the cancer-associated variant of p21cip1 may contribute to the loss of cell cycle control in neurons that may lead to Alzheimer-type neurodegeneration.'], ['Spatial learning and memory in rodents represent close equivalents of human episodic declarative memory, which is especially sensitive to cerebral aging, neurodegeneration, and various neuropsychiatric disorders.'], ['Better understanding of the signalling pathways and cellular events involved in ageing shows that these are characteristic of many chronic degenerative diseases, such as chronic obstructive pulmonary disease (COPD), chronic cardiovascular and metabolic diseases, and neurodegeneration.'], ['Aging results in increased rates of age related disorders like neurodegenerative diseases, cardiovascular diseases, diabetes, cancer, arthritis etc.', "We also checked the potential of silymarin to slow the progression of neurodegenerative disorder like Alzheimer's disease (AD) by using CL4176 C. elegans model for AD."], ['A leaky blood-brain barrier has long been implicated in cognitive dysfunction in aging and neurodegeneration, but reliable human data were lacking.'], ["The brains of patients suffering from Alzheimer's disease (AD) have three classical pathological hallmarks: amyloid-beta (Abeta) plaques, tau tangles, and neurodegeneration, including that of cholinergic neurons of the basal forebrain."], ['Corpora amylacea (CA) are glycoprotein-based depositions that accumulate in the normal aging brain or consecutively to different neuro-degenerative diseases.'], ["PURPOSE OF REVIEW: Alzheimer's disease is a complex multifactorial age-related neurodegenerative disorder."], ['Lots of epidemiological studies have put forward the beneficial effects of dietary polyphenols consumption in the prevention of diseases related to aging i.e vascular pathologies, neurodegeneration, cancers and associated inflammatory processes.'], ['Oxidative stress is thought to be one of the main mediators of neuronal damage in human neurodegenerative disease.'], ["Parkinson's disease (PD) is described as a progressive neurodegenerative disease related to age that influences quality of life (QoL) and leads to depression."], ["Alzheimer's disease (AD) is a progressive neurodegenerative disorder."], ['Loss of astroglial function and astroglial reactivity contributes to the aging of the brain and to neurodegenerative diseases.', 'Changes in astroglia in aging and neurodegeneration are highly heterogeneous and region-specific.', 'Astroglial morphology and function can be regulated through environmental stimulation and/or medication suggesting that astrocytes can be regarded as a target for therapies aimed at the prevention and cure of neurodegenerative disorders.'], ["Pin1 has also been implicated as being neuroprotective in aging-related neurodegenerative disorders including Alzheimer's disease where Pin1 activity is diminished.", 'Given the involvement of Pin1 in pathological processes related to neurodegenerative diseases and to cancer, these findings could have implications for the prevention or treatment of disease.'], ['OBJECTIVE: To investigate whether there is a difference in the cerebral Abeta fragment pattern in brain specimens from non-demented (PA) and demented (AD) individuals expressing the full neuropathological triad of AD (senile plaques, neurofibrillary tangles and neurodegeneration).'], ['Aging is the predominant risk factor for neurodegenerative diseases.', 'Whether chronic inflammation plays a causal role in cognitive decline in aging and neurodegeneration has not been established.', 'Our findings reveal a novel epigenetic mechanism in aging microglia that contributes to cognitive deficits in aging and neurodegenerative diseases.'], ['Participants with a cancer diagnosis (34.7%) had the most favorable functional trajectories (ie, lowest burden of disability), whereas those with neurodegenerative disease (21.1%) had the worst.', 'CONCLUSIONS: The course of disability in the year before hospice differs greatly among older persons but is particularly poor among those with neurodegenerative disease.'], ['Indeed, studies of animal models and human subjects demonstrate robust beneficial effects of regular exercise and intermittent energy restriction/fasting on cognitive function and mood, particularly in the contexts of aging and associated neurodegenerative disorders.'], ['Of particular interest in this regard is the brain, where it has been reported that DNA methylation impacts on neuronal activity, learning and memory, drug addiction and neurodegeneration.'], ['Some age-related neurodegenerative diseases have an etiology that is related to mitochondrial dysfunction.'], ['Projections suggest that the neurodegenerative diseases like PD will surpass cancer as the leading cause of death by the year 2040 [36]; thus presenting an ever-growing challenge to maintain an optimal quality of life of the patients.'], ['CONTEXT: Brain Iron Deposits (IDs) are associated with neurodegenerative diseases and impaired cognitive function in later life, but their cause is unknown.'], ['Redox regulators with antioxidant properties related to active mediators, cellular organelles, and the surrounding environments are all connected within a network and are involved in diseases related to redox imbalance including cancer, ischemia/reperfusion injury, neurodegenerative diseases, as well as normal aging.'], ['IMPORTANCE: Neurodegenerative diseases can cause dysfunction of neural structures involved in judgment, executive function, emotional processing, sexual behavior, violence, and self-awareness.'], ['Protracted systemic inflammation has been associated with adverse effects on cognition and brain structure and may accelerate neurodegenerative disease processes; however, it is less clear whether changes in inflammation are associated with brain structure.'], ["Parkinson's disease (PD) is one of the most common neurodegenerative diseases affecting an increasing number of people worldwide with the aging society."], ['In the central nervous system, senescence and neurodegeneration occur as a consequence of mitochondrial oxidative insults and impaired electron transfer.', 'Accumulated evidence thus far seems to indicate that catechins help prevent neurodegeneration and delay brain function decline.'], ['Failure to maintain mitochondrial health leads to numerous maladies that include late-onset neurodegenerative diseases and cardiovascular disorders.', "FUTURE DIRECTIONS: Delineating how coordinated action of the MQC modules orchestrates physiological responses on both organellar and cellular levels will further elucidate the current picture of MQC's role and function in health, cellular stress, and degenerative diseases."], ['Mitochondrial enzymes monoamine oxidases were thought to be an emerging and useful therapeutic target for neurodegenerative disorders.', 'Monoamine oxidases have two isoforms, A and B. MAO-A is related with metabolism of amine neurotransmitters in the brain whereas MAO-B is concerned with aging related neurodegenerative disorders.'], ['UNLABELLED: Non-enzymatic formation of advanced glycation endproducts (AGEs) is associated with degenerative diseases.', 'It induces tissue aging and degenerative diseases on the one hand, on the other hand, may also have protective effects, indicating a hormetic response.'], ['Chronic traumatic encephalopathy is a neurodegenerative disease produced by accumulated minor traumatic brain injuries; no definitive premortem diagnosis and no treatments are available for chronic traumatic encephalopathy.'], ["Alzheimer's disease (AD) has a complex and progressive neurodegenerative phenotype, with hypometabolism and impaired mitochondrial bioenergetics among the earliest pathogenic events."], ['We selected 148 drivers older than 70 years of age both with and without neurodegenerative diseases (Alzheimer disease-AD and Parkinson disease-PD) from an existing driving database of older adults.'], ['Carnosine and its imidazole-containing dipeptide derivatives are renowned for their anti-aging, antioxidant, membrane protective, metal ion chelating, buffering, anti-glycation/ transglycating activities used to prevent and treat a spectrum of age-related and metabolic diseases, such as neurodegenerative disease, sight threatening eye diseases, Diabetes mellitus and its complications, cancers and other disorders due to their wide spectrum biological activities.'], ['The association of VSEP latencies and SMI was studied in a healthy risk cohort, including 358 elderly subjects, who are in a longitudinal study of risk factors for neurodegenerative disorders.'], ['Cognitive deficits are common in older adults, as a result of both the natural aging process and neurodegenerative disease.'], ['These concepts are relevant to issues in modern human longevity, including inflammation-induced neoplasia and degenerative diseases of the elderly, which are a legacy of human evolution.', 'The hypothesis that we present provides new bases for modern medical problems, such as inflammation-induced neoplasia and degenerative diseases of the elderly.'], ['The protective effects against neurodegeneration could be in part due to the intake of flavonoids that have been associated with several health benefits such as antioxidant and anti-inflammatory activities, increased neuronal signaling, and improved metabolic functions.'], ['Several factors including physical decline and comorbidities in addition to neurodegeneration may be possible sources for MPS.', 'The objective was to examine whether MPS are associated with a history of orthopedic disturbances, vascular diseases or prodromal markers for neurodegeneration.', 'METHODS: The TREND study is a prospective longitudinal cohort study in individuals >50 years with biennial assessments designed to identify prodromal markers for neurodegeneration.', 'In this substudy, 1091 elderly individuals were evaluated for a possible association of MPS with prodromal markers for neurodegeneration, orthopedic disturbances, vascular diseases, as well as cerebral abnormalities.', 'CONCLUSION: MPS might be a sign of early neurodegeneration rather than caused by other motor influencing diseases.'], ["BACKGROUND: Alzheimer's disease (AD) is the most common neurodegenerative disease in the elderly, and close associations between AD and diabetes have been found."], ["Parkinson's disease (PD) is the second most common neurodegenerative disorder, after Alzheimer's disease, affecting the elderly worldwide."], ["Alzheimer's disease (AD) is a neurodegenerative disorder which is the most common cause of dementia in the elderly today."], ['Such imaging studies will comprise non-invasive assessment of the spatial and temporal pattern of tau deposition over time, providing insight into the role tau plays in ageing and helping to establish the relation between cognition, genotype, neurodegeneration, and other biomarkers.'], ["There is increasing evidence that epigenetic modifications may become compromised in aging and increase susceptibility to the development of neurodegenerative disorders such as Alzheimer's disease."], ['Autophagic dysregulation has been suggested in a broad range of neurodegenerative diseases including age-related macular degeneration (AMD).'], ['As our society ages, neurodegenerative disorders like Parkinson`s disease (PD) are increasing in pandemic proportions.', 'Alleviation of PD-related neurodegeneration by spermidine was accompanied by induction of autophagy, suggesting that this cytoprotective process may be responsible for the beneficial effects of spermidine administration.'], ['Here we focused on long-living participants of the Long Life Family Study (LLFS), their offspring, and spouses to: (1) Elucidate whether trade-offs in the effect of the apolipoprotein E e4 allele documented in the Framingham Heart Study (FHS) are a more general phenomenon, and (2) explore potential mechanisms generating age- and gender-specific trade-offs in the effect of the e4 allele on cancer, diseases of the heart, and neurodegenerative disorders assessed retrospectively in the LLFS populations.'], ['Misregulation of autophagy is likely involved in numerous human pathologies including aging, cancer, infections and neurodegeneration, so its biomedical relevance explains the still growing interest in this field.'], ['BACKGROUND: Dietary antioxidants can inhibit reactions accompanying neurodegeneration and thus prevent cognitive impairment.'], ['Degenerative spinal diseases increased 79.7 %.'], ['Frontotemporal dementia (FTD) is a neurodegenerative behavioral disorder that selectively affects the salience network, including the ventral striatum and insula.'], ['We conclude that multiple genes play important roles in HS-Aging, which is a distinctive neurodegenerative disease of aging.'], ['Elevated ROS concentrations are associated with aging, inflammatory and degenerative diseases.'], ["Alzheimer's disease (AD) is one of the most common neurodegenerative disorders, which causes the deterioration of memory and other cognitive abilities of the elderly."], ['Finally, we present a summary of recent studies of orexin in neurodegenerative disease.'], ['The brain is highly susceptible to oxidative stress, which increases during ageing and is considered a major contributor to neurodegeneration.', 'Therefore, the benefit of vitamin E as a treatment for neurodegenerative disorders is still under debate.'], ["Alzheimer's disease certainly represents one of the most relevant neurodegenerative disorders due to its incidence and its huge socio-economic impact.", "Therefore, it is easy to understand why recent literature focuses on the epigenetic modifications associated with Alzheimer's disease and other neurodegenerative disorders."], ['Thus neurodegeneration and aging may lay a foundation that is actually beneficial for this particular type of gene therapy while other gene therapy techniques that target neurons are actually targeting cells that are decreasing as the disease progresses.'], ['BACKGROUND: There is increasing interest in interactions between metabolic syndromes and neurodegeneration.', 'OBJECTIVE: To investigate effects of comorbid DM on cognition in PD independent from PD-specific primary neurodegenerations.', 'CONCLUSION: Diabetes mellitus is independently associated with more severe cognitive impairment in PD likely through mechanisms other than disease-specific neurodegenerations.'], ["We evaluated whether an increase in the Unified Parkinson's Disease Rating Scale part III (UPDRS-III) could be predicted by the presence of risk and prodromal markers for neurodegenerative diseases in elderly individuals without those diseases.", 'Therefore, we analyzed the UPDRS-III score and various risk and prodromal markers known to antecede neurodegenerative diseases in a population-based cohort comprising 807 individuals free of neurodegenerative diseases at baseline.', 'Our data support the assumption that progression of Parkinsonian signs assessed by the UPDRS-III parallels the development of prodromal markers for neurodegenerative diseases in the elderly population.'], ['SAMP10-DeltaSglt2 mice may serve as a unique preclinical model to study the link between aging-related neurodegenerative disorders and T2D.'], ['It belongs to Neurodegeneration with Brain Iron Accumulation, a group of disorders where iron dysregulation is tightly associated with neurodegeneration.'], ['Alterations in stem-cell homeostasis can contribute to the consequences of neurodegenerative diseases, healthy ageing and tissue repair after damage.'], ['BMSCs may be sensitive to age-related diseases and could perpetuate degenerative diseases in which bone remodeling is a contributory factor.'], ['Here, we evaluated the hypothesis that amplitude of these occipital sources is related to neurodegeneration in occipital lobe as measured by magnetic resonance imaging.', 'Neurodegeneration of occipital lobe was indexed by weighted averages of gray matter density, estimated from structural MRIs.', 'These results suggest that the amplitude of occipital sources of resting-state alpha rhythms is related to AD neurodegeneration in occipital lobe along pathologic aging.'], ['Cockayne syndrome (CS) is an accelerated aging disorder characterized by progressive neurodegeneration caused by mutations in genes encoding the DNA repair proteins CS group A or B (CSA or CSB).'], ['Although clusterin is known to be involved in neurodegenerative diseases, ageing, and tumorigenesis, a detailed analysis of the consequences of gain- or loss-of-function approaches has yet to be performed to understand the underlying mechanisms of clusterin functions.', 'To analyze the function of clusterin in neurodegeneration, a transgenic zebrafish was investigated, in which nitroreductase expression is regulated under the control of a neuron-specific huC promoter which is active between the stages of early neuronal precursors and mature neurons.', 'Interestingly, we also observed a dramatic induction of clusterin expression in the brain and spinal cord in these fish, suggesting a direct or indirect role of clusterin in neuronal cell death and thus, more generally, in neurodegeneration.'], ['Beclin-1, a well-known key regulator of autophagy, has been implicated in many disorders, including cancer, aging, and degenerative diseases.'], ['CONCLUSIONS: The effectiveness of the various treatments for cervical spine degenerative disorders is influenced by the overall anatomical conditions of the cervical spine.'], ['Misfolded proteins (MP) are a key component in aging and associated neurodegenerative disorders.', 'In sum, the proposed ESM constitutes a promising framework to clarify intra-brain region to region transference mechanisms associated with aging and neurodegenerative disorders.'], ['Most human neurodegenerative diseases are sporadic, and appear later in life.', 'The defect in retrieval of BiP by the KDEL receptor leads to impaired activities in quality control and autophagy, suggesting that functional defects in the ER chaperones may contribute to the late onset of neurodegenerative diseases.'], ['AD pathogenesis involves neurodegeneration but also aberrant regenerative, or reactive anabolic, burden, while cancer development is driving by uncontrolled proliferation inherent with excessive anabolic activity.', 'SUMMARY: The reduced prevalence of AD in cancer survivors may implicate a strong impact of aberrant neural regenerative burden in neurodegeneration.'], ['Parkinson disease (PD) is a multi-factorial neurodegenerative disorder with loss of dopaminergic neurons in the substantia nigra and characteristic intracellular inclusions, called Lewy bodies.', 'Genetic predisposition, such as point mutations and copy number variants of the SNCA gene locus can cause very similar PD-like neurodegeneration.', 'Our goal was to determine if these cells these neuronal precursor cells already display pathological changes and impaired cellular function that would likely predispose them when differentiated to neurodegeneration.'], ['These findings nominate FASTKD2 as a target for modulating neurodegeneration and suggest potential mechanisms for therapies to combat memory loss in normal cognitive aging and dementia.'], ['Findings suggest MetS, and in particular blood pressure, may represent markers of vascular or neurodegenerative damage in aging populations.'], ['Dysfunctional DJ-1, which lacks this transnitrosylation activity due to mutation or prior oxidation (e.g., sulfonation) of the critical cysteine thiol, could thus contribute to neurodegenerative disorders like PD.'], ["However, though the majority of cases improve after drug cessation, parkinsonian symptoms can persist and should prompt investigation into underlying degenerative parkinsonism, as valproate can unmask idiopathic Parkinson's disease in susceptible individuals."], ["Alzheimer's disease (AD) is a complex neurodegenerative disorder and the primary cause of dementia in the elderly and causes a decrease in cognition, functionality, and behaviour."], ['IMPORTANCE: Pathophysiologic mechanisms leading to loss of white matter integrity and the temporal positioning of biomarkers of white matter integrity relative to the biomarkers of gray matter neurodegeneration and amyloid load in the course of Alzheimer disease (AD) are poorly understood.', 'OBJECTIVE: To investigate the effects of AD-related gray matter neurodegeneration and high beta-amyloid on white matter microstructure in older adults without dementia.', 'Both groups were divided into biomarker-negative, amyloid-positive-only, neurodegeneration-positive-only, and amyloid plus neurodegeneration-positive groups based on their amyloid load shown on carbon 11-labeled Pittsburgh Compound B positron emission tomography, AD hypometabolic pattern shown on fludeoxyglucose F 18 positron emission tomography, and/or hippocampal atrophy shown on magnetic resonance imaging.', 'Conversely, the neurodegeneration-positive-only and amyloid plus neurodegeneration-positive CN and MCI groups consistently had decreased FA in the fornix, which correlated with cognitive performance (rho = 0.38; P < .001).', 'Patients with MCI had more extensive white matter involvement than did those with CN, and the greatest FA decreases were observed in the amyloid plus neurodegeneration-positive MCI group (P < .05; familywise error corrected).', 'CONCLUSIONS AND RELEVANCE: A high amyloid load does not influence diffusion tensor imaging-based measures of white matter integrity in the absence of coexistent gray matter neurodegeneration in older adults without dementia.'], ['Cardiovascular diseases (CVD), cancer, diabetes and neurodegenerative diseases are collectively amounting to more than 60% of non-communicable disease burden across world.'], ['Then based on the gene expression, PPI and signalling pathways data, we investigate the comorbidity association of these 2 infective pathologies with other 7 diseases (heart failure, kidney disorder, breast cancer, neurodegenerative disorders, bone diseases, Type 1 and Type 2 diabetes).'], ["Alzheimer's disease (AD) is a progressive and neurodegenerative disorder that induces dementia in older people.", 'Pathologic characteristics of AD are beta-amyloid plaques, neurofibrillary tangles and neurodegeneration.', 'Recently, stem cell therapy has been shown to be a potential approach to various diseases, including neurodegenerative disorders, and in this review, we focus on stem cell therapies for AD.'], ['Knowing these changes may elucidate structural, metabolic, and functional brain processes over the lifespan, as well vulnerability to neurodevelopmental or neurodegenerative diseases.'], ["Neurofibrillary tangles (NFTs), composed of truncated and hyperphosphorylated tau, are a common feature of numerous aging-related neurodegenerative diseases, including Alzheimer's disease (AD).", 'Here we show that asparagine endopeptidase (AEP), a lysosomal cysteine proteinase, is activated during aging and proteolytically degrades tau, abolishes its microtubule assembly function, induces tau aggregation and triggers neurodegeneration.', 'Inhibition of AEP may be therapeutically useful for treating tau-mediated neurodegenerative diseases.'], ['Among individuals, biological aging leads to cellular and organismal dysfunction and an increased risk of chronic degenerative diseases and disability.'], ['BACKGROUND AND OBJECTIVE: The enigmatic etiology of neurodegenerative diseases poses a challenge for the development of novel and efficient drugs.'], ['Abnormally elevated iron levels have been found in various neurodegenerative diseases.', 'Additionally, iron overload and related neurodegeneration may also occur during aging, but the functional consequences are not clear.'], ["Dysregulation of the nucleolus is considered to be a cellular stress event associated with aging and neurodegenerative disease, including Parkinson's disease (PD)."], ['Sirtuins, a group of class III deacetylases, have gained considerable attention for their positive effects on aging-related disease, such as cancer, cardiovascular disease, neurodegenerative diseases, osteoporosis and COPD.'], ['On X-ray, there was no significant difference between groups in terms of glenohumeral and/or acromioclavicular degenerative changes.'], ['Recent data generated by several laboratories suggest that both aging and age-related neurodegenerative diseases are accompanied by an increase in SASP-expressing senescent cells of non-neuronal origin in the brain.', 'Moreover, this increase correlates with neurodegeneration.'], ['However, its influence on the neurodegeneration that occurs in early AD remains unresolved.'], ['SIRT1 can induce chromatin silencing through the deacetylation of histones and plays an important role as a key regulator of a wide variety of cellular and physiological processes including DNA damage, cell survival, metabolism, aging, and neurodegeneration.', 'It has gained a lot of attention recently because many studies in animal models of demyelinating and neurodegenerative diseases have shown that SIRT1 induction can ameliorate the course of the disease.'], ["Aging is the major risk factor for the development of human neurodegenerative maladies such as Alzheimer's, Huntington's and Parkinson's diseases (PDs) and prion disorders, all of which stem from toxic protein aggregation."], ['Osteoarthritis (OA) is a degenerative disease, which is characterized by articular cartilage destruction, and mainly affects the older people.'], ["This paper summarizes pathological changes that affect microglial cells in the human brain during aging and in aging-related neurodegenerative diseases, primarily Alzheimer's disease (AD)."], ['One-hundred-and-four patients without a history of treatment of stroke and without a diagnosis of neurodegenerative disease (36 men and 68 women), with a mean age of 84.1 +- 5.6 years, hospitalized from May 2013 to June 2013 were included in this study.'], ['In one of the largest voxel-based cross-sectional studies to date, PA and lower BMI may be beneficial to the brain across the spectrum of aging and neurodegeneration.'], ['Participants met strict inclusion criteria for the absence of any active or past neurodegenerative disorders and performed within normal limits on other neuropsychological measures.'], ['Sporadic inclusion-body myositis (s-IBM) is the most common degenerative muscle disease in which aging appears to be a key risk factor.', "The intriguing phenotypic similarities between s-IBM muscle fibers and the brains of Alzheimer and Parkinson's disease patients, the two most common neurodegenerative diseases associated with aging, are also discussed."], ['To address whether underlying neurodegenerative pathology increased susceptibility to acute cognitive change, mice at three stages of neurodegenerative disease progression (ME7 model of neurodegeneration: controls, 12 weeks, and 16 weeks) were assessed for acute cognitive dysfunction upon systemic inflammation induced by bacterial lipopolysaccharide (LPS; 100 mug/kg).', 'CONCLUSION: A human population-based cohort with graded severity of existing cognitive impairment and a mouse model with progressing neurodegeneration both indicate that the risk of delirium increases with greater severity of pre-existing cognitive impairment and neuropathology.'], ['Understanding the mechanisms of neurodegeneration in PD and AD may, therefore, improve efforts to manage and treat PD dementia.'], ['Oxidative stress induced by reactive oxygen species (ROS) is the major cause of degenerative disorders including aging and disease.'], ["In the patient's brain, generalized astrogliosis, and enhanced LC3, ubiquitin, and Tau signals were identified in the regions surrounding macrophage clusters, indicating proinflammation, altered autophagy, and neurodegeneration."], ['BACKGROUND: Loss of brain white matter microstructure is presumed to be an early sign of neurodegenerative disease.', 'CONCLUSIONS: Microstructure of white matter tracts changes with age, and may mark neurodegeneration more sensitively than white matter lesion load and atrophy.'], ["OBJECTIVES: Parkinson's disease (PD) is a multisystem neurodegenerative disease.", 'CONCLUSIONS: Our results suggest that aging, PD-related pathogenesis, and disease duration underlie the multisystem neurodegeneration present in PD.'], ["We aimed to characterise how typical ageing and preclinical Alzheimer's disease overlap in terms of beta-amyloidosis and neurodegeneration.", 'METHODS: We measured age-specific frequencies of amyloidosis and neurodegeneration in individuals with normal cognitive function aged 50-89 years.', "Amyloid status (positive [A(+)] or negative [A(-)]) was determined by amyloid PET with (11)C Pittsburgh compound B. Neurodegeneration status (positive [N(+)] or negative [N(-)]) was determined by an Alzheimer's disease signature (18)F-FDG PET or hippocampal volume on MRI.", 'We determined age-specific frequencies of the four groups (amyloid negative and neurodegeneration negative [A(-)N(-)], amyloid positive and neurodegeneration negative [A(+)N(-)], amyloid negative and neurodegeneration positive [A(-)N(+)], or amyloid positive and neurodegeneration positive [A(+)N(+)]) cross-sectionally using multinomial regression models.', 'INTERPRETATION: Accumulation of amyloid and neurodegeneration are nearly inevitable by old age, but many people are able to maintain normal cognitive function despite these imaging abnormalities.', 'Changes in the frequency of amyloidosis and neurodegeneration with age, which seem to be modified by APOE e4 and sex, suggest that pathophysiological sequences might differ between individuals.'], ["Many chronic diseases seen in the elderly such as atherosclerosis, diabetes, neuro-degenerative disorders, Parkinson's disease and age related macular degeneration (AMD) may be due to chronic inflammation and increased oxidative stress."], ['Joints are prone to damage caused by sports injuries or aging, and such damage regularly progresses to more serious joint disorders, including osteoarthritis, which is a degenerative disease characterized by the thinning and eventual wearing out of articular cartilage, ultimately leading to joint destruction.'], ['INTRODUCTION: Neurodegenerative diseases share common pathologic features including neuroinflammation, mitochondrial dysfunction and protein aggregation, suggesting common underlying mechanisms of neurodegeneration.', 'We undertook a meta-analysis of public gene expression data for neurodegenerative diseases to identify a common transcriptional signature of neurodegeneration.', 'RESULTS: Using 1,270 post-mortem central nervous system tissue samples from 13 patient cohorts covering four neurodegenerative diseases, we identified 243 differentially expressed genes, which were similarly dysregulated in 15 additional patient cohorts of 205 samples including seven neurodegenerative diseases.', 'Evaluation of genes enriched in neurons revealed 70 down-regulated genes, over half not previously associated with neurodegeneration.', 'Comparison with aging brain data (3 patient cohorts, 221 samples) revealed 53 of these to be unique to neurodegenerative disease, many of which are strong candidates to be important in neuropathogenesis (e.g.', 'Finally, we removed genes common to neurodegeneration from disease-specific gene signatures, revealing uniquely robust immune response and JAK-STAT signaling in amyotrophic lateral sclerosis.', 'CONCLUSIONS: Our results implicate pervasive bioenergetic deficits, M1-type microglial activation and gliosis as unifying themes of neurodegeneration, and identify numerous novel genes associated with neurodegenerative processes.'], ["Parkinson's disease (PD) is the second most prevalent neurodegenerative disease among aging individuals, affecting greatly the quality of their life."], ['Atherosclerosis (AT) was once considered to be a degenerative disease that was an inevitable consequence of aging.'], ['BACKGROUND: Object-location memory is critical in every-day life and known to deteriorate early in the course of neurodegenerative disease.'], ["Neurodegenerative diseases, such as Alzheimer's disease (AD), are associated with a decay of circadian rhythms, but it is not clear whether circadian disruption accelerates neuronal and motor decline associated with these diseases."], ['CONCLUSIONS: The use of psychotropic medication in the elderly is associated with increased mortality, independent of concurrent neurodegeneration due to PD.', 'Our findings indicate that neurodegeneration should not be a separate contraindication per se for the use of psychotropic drug in patients with PD, but its use should be based on careful clinical evaluation and follow-up.'], ["Long-term exposure to environmental oxidative stressors, like the herbicide paraquat (PQ), has been linked to the development of Parkinson's disease (PD), the most frequent neurodegenerative movement disorder.", 'Further studies of DAMB signaling in Drosophila could have implications for better understanding DA-related neurodegenerative disorders in humans.'], ['In this study the role of carnosine and related neuron specific naturally-occurring endogenous imidazole-containing dipeptide pharmacoperones (N-acetylcarnosine, carcinine) is revealed presently in a surprisingly large amounts in long-lived human tissues to correct conformational abnormalities leading to distinct neurodegeneration and age-related disease states, treating cognitive deficits, depression and intellectual disabilities.', 'The roles for the carnosine-stimulated/mediated neuronal histamine system are proposed as a danger and physiological response system active in protection from neurodegenerative diseases and in management of cognitive deficits, depression and intellectual disabilities.'], ['Stem cell technologies have created new opportunities to generate unlimited numbers of human neurons in the lab and study neurodegenerative disorders such as amyotrophic lateral sclerosis (ALS) and spinal muscular atrophy (SMA).', 'The problem with these stem cell models lies in the disparity between the advanced age of onset of neurodegenerative disorders and the embryonic nature of the in vitro derived cell types.', 'In this review we discuss experimental methods of in vitro aging of neural cell types as a means to elicit late-onset symptoms in induced pluripotent stem cell (iPSC) models of neurodegenerative disease.'], ['In addition, TDO has been implicated as a key regulator of neurotoxicity involved in neurodegenerative diseases and ageing.'], ["Mitochondrial dysfunction plays an important role in brain aging and has emerged to be an early event in Alzheimer's disease (AD), contributing to neurodegeneration and the loss of physical abilities seen in patients suffering from this disease."], ["Alzheimer's disease (AD), a progressive neurodegenerative disorder that is the most common cause of dementia in the elderly, is characterized by the accumulation of amyloid-beta (Abeta) plaques and neurofibrillary tangles, as well as a progressive loss of synapses and neurons in the brain."], ['Human intravenous immunoglobulin (IVIG) has been indicated as a potential therapy for autoimmune neurological disorders, as well as in many neurodegenerative diseases, with various underlying therapeutic mechanisms such as regulation of T-cell trafficking, cytokines, Fc receptor blocking, and interruption of complement activation cascade.'], ['Therefore, our findings suggest that IVIG treatment may represent an important therapeutic agent for clinical trials designed to prevent and delay the onset of neurodegeneration as well as AD pathology.'], ['Human post-mortem brain tissue, mostly provided by brain banks, is precious because most human neurodegenerative diseases are restricted in their complete forms to human beings.'], ['BER thus maintains genome stability, and prevents the development of human diseases, such as premature aging, neurodegenerative diseases and cancer.'], ['It has been increasingly recognized that co-occurrence of neurodegenerative proteinopathies and other pathologies including cerebrovascular disorders is a frequent event in the brains of both cognitively intact and impaired aged subjects.', 'Although clinical and neuropathological diagnostic criteria of the major neurodegenerative diseases have been improved, major challenges arise from cerebral multimorbidity, and the thresholds to cause clinical overt dementia are ill defined.', 'These data clearly suggest that pathologically deposited proteins in neurodegenerating diseases mutually interact and are influenced by other factors, in particular cardiovascular and cerebrovascular ones, to promote cognitive decline and other clinical symptoms.'], ['A nonfusion stabilization system with motion preservation has been recently used for degenerative spinal diseases with favorable outcomes.'], ['Evidence suggests that normal pressure hydrocephalus (NPH) is underdiagnosed in day to day radiologic practice, and differentiating NPH from cerebral atrophy due to other neurodegenerative diseases and normal aging remains a challenge.'], ["Using expression profiles from postmortem prefrontal cortex samples of 624 dementia patients and non-demented controls, we investigated global disruptions in the co-regulation of genes in two neurodegenerative diseases, late-onset Alzheimer's disease (AD) and Huntington's disease (HD)."], ["Known as Lafora bodies (LBs), these deposits result in the aggressive neurodegeneration seen in Lafora's disease."], ['Cellular events responsible for the initiation of major neurodegenerative disorders of the eye leading to blindness, including age-related macular degeneration, Stargardt and Best diseases, are poorly understood.'], ["Parkinson's disease (PD) is a chronic neurodegenerative disease underpinned by both genetic and environmental etiologic factors."], ['Within the proposed "neurodegeneration paradigm", observations have been put forth for "accelerated aging" in this disorder.'], ['To understand HTR2A signalling changes in psychiatric or neurodegenerative disorders, its normal pattern of brain expression and region specificity during development and ageing needs to be clarified.', 'CONCLUSIONS: Our results show plasticity and region specificity of HTR2A expression regulation in human brain with age, which may be important for the interaction with other neurotransmitter systems and for the occurrence of developmental periods with increased vulnerability to neuropsychiatric or neurodegenerative disorders.'], ['Somatic (acquired) mtDNA mutations are also associated with degenerative diseases and with normal human ageing.'], ["Alzheimer's disease (AD) is a complex neurodegenerative disorder that is the most common form of dementia in the elderly and is characterized by progressive memory loss and cognitive dysfunction."], ["Alzheimer's disease (AD) is the most common neurodegenerative disorder among the elderly individuals."], ['Previous studies of CNPP clean-up workers from Latvia revealed a high occurrence of age-associated degenerative diseases and cancer in young adults, as well as a high mortality as a result of cardiovascular disorders at age 45-54 years.'], ["Alzheimer's disease (AD) is the most common neurodegenerative disorder and the primary form of dementia in the elderly."], ['There is growing evidence that a variety of biochemical processes that underlie the most frequent neurodegenerative diseases may have much in common with those connected with natural aging.', 'These observations, though preliminary, shed the light on a putative contribution of various pathological lipid- and protein-related processes underlying senescence, suggesting a "biochemical link" between the aetiology of the most common neurodegenerative diseases and physiological aging.'], ['XPA patients also exhibit neurodegeneration, leading to cerebellar atrophy, neuropathy, and hearing loss, through a mechanism that has remained elusive.', 'This study underscores the importance of mitophagy in promoting a healthy pool of mitochondria and in preventing neurodegeneration and premature aging.'], ['The role of fusion, in the absence of a degenerative deformity, is uncertain.'], ['METHODS: Data from the Arizona Study of Aging and Neurodegenerative Disorders were used to determine the predictive value of a clinical PD diagnosis, using 2 clinical diagnostic confidence levels, PossPD (never treated or not clearly responsive) and ProbPD (responsive to medications).'], ['Mutations in human CISD2 cause type 2 Wolfram syndrome, a rare neurodegenerative and metabolic disorder associated with a shortened lifespan.'], ["Alzheimer's dementia (AD) is the most common neurodegenerative disorder, which affects 30 million people worldwide."], ['The proton-translocating NADH-quinone oxidoreductase (complex I/NDH-1) is the first and largest enzyme of the respiratory chain which has a central role in cellular energy production and is implicated in many human neurodegenerative diseases and aging.'], ['Mice that lack TERT age much faster and exhibit age-related conditions such as osteoporosis, diabetes and neurodegeneration.'], ['Strong tendency toward statistically significant decreased NAA/Cr in the left cerebral hemisphere, predominantly parietal region and strong tendency toward statistically significant decreased Cho/Cr at the left frontal region were indicative of neurodegeneration and replacement by gliosis.'], ['The PET template currently used for SPM normalization is based on [15O]-H2O images and does not resemble either the specific metabolic features of [18F]-FDG brain scans or the specific morphological characteristics of individual brains affected by neurodegeneration.'], ['For this reason, gangliosides are important diagnostic markers for various brain ailments, including primary and secondary brain tumors and neurodegenerative diseases.'], ['Patients with neurodegenerative diseases, particularly those with right frontal involvement, often present with poor self-awareness of their functional limitations that may exacerbate their already jeopardized decision-making and behaviour.', 'We studied the structural neuroanatomical basis for impaired self-awareness among patients with neurodegenerative disease and healthy older adults.', "One hundred and twenty-four participants (78 patients with neurodegenerative diseases including Alzheimer's disease, behavioural variant frontotemporal dementia, right-temporal frontotemporal dementia, semantic variant and non-fluent variant primary progressive aphasia, and 46 healthy controls) described themselves on the Patient Competency Rating Scale, rating observable functioning across four domains (daily living activities, cognitive, emotional control, interpersonal)."], ['The aim of this systematic review was to identify and evaluate the evidence of the efficacy of stochastic resonance whole-body vibration (SR-WBV) on static, dynamic and functional balance in the elderly and in patients with neurodegenerative diseases.', 'There is only limited evidence that SR-WBV may be effective in improving static, dynamic and functional balance among elderly individuals and patients with neurodegenerative diseases.'], ['Neurodegenerative diseases, such as Alzheimer s Disease (AD), have high prevalence in the elderly population.'], ["Alzheimer's disease (AD) is a progressive degenerative disorder of the brain and is the most common form of dementia.", 'Human buccal cells for instance are accessible in a minimally invasive manner, and exhibit cytological and nuclear morphologies that may be indicative of accelerated ageing or neurodegenerative disorders such as AD.'], ['1H-MRS variability increases due to normal aging and also as a result of atrophy in grey and white matter caused by neurodegeneration.', 'Our findings suggest that knowing the voxel composition of white and grey matter and cerebrospinal fluid is necessary to avoid partial volume variations in a single-voxel study and to decrease part of the variability found in metabolites quantification, particularly in those studies involving elder patients and neurodegenerative diseases.'], ['Therefore, the use of metabolomics can help to unravel the diversity-and to disclose the specificity-of metabolic traits and their alterations in the brain and in fluids such as cerebrospinal fluid and plasma, thus helping to uncover potential biomarkers of aging and neurodegenerative diseases.', 'Here, we review the current applications of metabolomics in studies of CNS aging and certain age-related neurodegenerative diseases such as Alzheimer disease, Parkinson disease, and amyotrophic lateral sclerosis.'], ['The mammalian target of rapamycin (mTOR) signaling pathway is a key developmental pathway involved in mechanisms underlying cellular aging and neurodegeneration.', 'These findings suggest that a dysregulated mTOR pathway may contribute to both early hippocampal developmental abnormalities and hippocampal functional impairment developing before neurodegeneration.'], ['There has been renewed interest in vitamin D since numerous recent studies have suggested that besides its well-established roles in bone metabolism and immunity, vitamin D status is inversely associated with the incidence of several diseases, e.g., cancers, cardio-vascular diseases, and neurodegenerative diseases.'], ['Here, we describe a syndrome in which the cardinal clinical features include short stature, hearing loss, premature aging, telangiectasia, neurodegeneration, and photosensitivity, resulting from a homozygous missense (p.Ser228Ile) sequence alteration of the proliferating cell nuclear antigen (PCNA).', 'Together, our findings detail a mutation of PCNA in humans associated with a neurodegenerative phenotype, displaying clinical and molecular features common to other DNA repair disorders, which we showed to be attributable to a hypomorphic amino acid alteration.'], ["The preliminary longitudinal studies of elderly individuals suggest that longer telomeres are associated with better survival and an advanced oral pharmaconutrition provision with non-hydrolyzed carnosine (or carcinine and patented compositions thereof) is a useful therapeutic tool of a critical telomere length maintenance (allowing indirectly to manipulate with telomerase activity) that may fundamentally be applied in the therapeutic treatment of agerelated sight-threatening eye disorders, Diabetes mellitus, sarcopenia (that is the gradual loss of muscle mass) that can affect elderly people and subjects under the effect of exhausting exercises and physical load, prolong life expectancy, increase survival and chronological age of an organism in health control, smoking behavior, metabolic syndrome increasing the risk of developing cardio-vascular diseases, age-related neurodegenerative diseases, including Alzheimer's disease and cognitive impairment."], ["On the basis of histopathological observations in human brain, we believe that the ability of microglia to provide neuroprotection deteriorates as our brains get older and that such CNS immune senescence is a major factor contributing to the development of aging-related neurodegenerative diseases, notably Alzheimer's disease.", 'There is an analogous situation in the brain, except that here the main impact comes down to diminished neuroprotection and resultant neurodegeneration.'], ['These findings suggest that increasing intake of folate and B6 might reduce Pb-associated increases in homocysteine, a risk factor for cardiovascular disease and neurodegeneration.'], ['Neurodegenerative diseases affecting the macula constitute a major cause of incurable vision loss and exhibit considerable clinical and genetic heterogeneity, from early-onset monogenic disease to multifactorial late-onset age-related macular degeneration (AMD).'], ['Hence, greater MAO-A VT during perimenopause may represent a new target for assessing novel interventions to prevent mood disorders and reduce longer-term risk of neurodegenerative disease.'], ['Haplogroups in mitochondrial DNA (mtDNA) mark individual differences in oxidative potential and are possible determinants of neurodegeneration.'], ['Focal RC defects are also associated with ageing and neurodegenerative disorders, e.g.'], ['Degenerative disorders as causes of EOD are not rare.'], ['Evidence for dramatic neurodegeneration in aging HIV+ persons remains limited and may be different in nature to typical neurodegenerative processes.'], ['Regular nut consumption, berry consumption, or both could possibly be used as an adjunctive therapeutic strategy in the treatment and prevention of several neurodegenerative diseases and age-related brain dysfunction.', 'A number of animal and a growing number of human studies show that moderate-duration dietary supplementation with nuts, berry fruit, or both is capable of altering cognitive performance in humans, perhaps forestalling or reversing the effects of neurodegeneration in aging.'], ['This interest is rooted in the cumulative evidence connecting active oxygen and free radicals with numerous human degenerative disorders, such as cardiovascular diseases, cancer, aging, and atherosclerosis.'], ['While accepted as normal in young children up to 2 years of age, drooling in older children and adolescents is secondary to altered orofacial neuromuscular control during development, and in the elderly it is a consequence of neurodegenerative disease.'], ['OBJECTIVE: Polymerase gamma (POLG) mutations are a common cause of mitochondrial disease and have also been linked to neurodegeneration and aging.', 'We studied the molecular mechanisms underlying POLG-related neurodegeneration using postmortem tissue from a large number of patients.', 'Progressive neurodegeneration primarily affected the cerebellar systems and dopaminergic cells of the substantia nigra.', 'This leads to 2 distinct but overlapping biological processes: a chronic neurodegeneration reflected clinically by progressive ataxia and cognitive impairment, and an acute focal neuronal necrosis that appears to be related to the presence of epileptic seizures.'], ['The current advances in the understanding of the mechanisms and regulation of proteostasis and of the different types of digressions in this process in aging have turned the attention toward the therapeutic opportunities offered by the restoration of proteostasis in age-associated degenerative diseases.'], ['The use of in vivo amyloid imaging agents, such a Pittsburgh Compound-B and markers of neurodegeneration, such as fluoro-2-deoxy-D-glucose (FDG) is able to detect early AD pathological processes and subsequent neurodegeneration.'], ['The cell biology of human neurodegenerative diseases has been difficult to study till recently.', "In this review, we highlight accomplishments made using iPSC models to study neurodegenerative disorders such as Huntington's disease, Parkinson's disease, Amyotrophic Lateral Sclerosis, Fronto-Temporal Dementia, Alzheimer's disease, Spinomuscular Atrophy and other polyglutamine diseases.", 'We also discuss prospects for the future of using of iPSC models of neurodegenerative disorders, including screening and testing of therapeutic compounds, and possibly of cell transplantation in regenerative medicine.'], ['Increasing evidence suggest that activation of the peripheral immune system exacerbates the discordant central inflammatory response and synergistically drives neurodegeneration.'], ['With the increasing prevalence of cognitive decline associated with neurodegenerative diseases among the ageing population, physical exercise, a potent enhancer of adult hippocampal neurogenesis, has emerged as a potential preventative strategy/treatment to reduce cognitive decline.', 'Here we review the functional role of adult hippocampal neurogenesis in learning and memory, and how this form of structural plasticity is altered in neurodegenerative diseases known to involve cognitive impairment.'], ["With advancing age, HIV + individuals may be at increased risk of developing other potential neurodegenerative disorders [especially Alzheimer's disease (AD)]."], ['Clusterin affects inflammation, immune responses, and amyloid clearance, which in turn may result in neurodegeneration.'], ["Alzheimer's disease is a multi-factorial neurodegenerative disorder devastatingly affecting the aged population worldwide."], ['The effect of APOE epsilon4 carriage in this group of subjects does not appear to modify their hypometabolic "AD-like" neurodegeneration.'], ["Alzheimer's disease (AD) is a progressive neurodegenerative disorder and is the most common cause of dementia in the elderly."], ['To elucidate the mechanisms related to the development of type 2 diabetes (T2D) and other degenerative diseases at a molecular level, a better understanding of the changes in the chromatin structure and the corresponding functional changes in molecular pathways is still needed.'], ['Selenoproteins use the rare amino acid selenocysteine (Sec) to act as the first line of defense against oxidants, which are linked to aging, cancer, and neurodegenerative diseases.'], ['Vascular risk factors and comorbidity relationships with cognitive decline and AA are discussed to facilitate strategies for advancing AA research in the area of brain health and neurodegeneration.'], ['Accordingly, glucose hypometabolism within the brain may result in disruption of the normal functions of O-GlcNAc within the brain and thereby contribute to downstream neurodegeneration.', 'In this review we summarize the state of knowledge in the area of O-GlcNAc as it pertains to AD while also addressing some of the basic biochemical roles of O-GlcNAc and how these might contribute to protecting against AD and other neurodegenerative diseases.'], ['Falls are considered as major health hazards for both the elderly and people with neurodegenerative diseases.'], ["The microtubule-associated protein Tau is responsible for a large group of neurodegenerative disorders, known as tauopathies, including Alzheimer's disease."], ['AD, a devastating neurodegenerative disorder, is the most common cause of dementia in the elderly.'], ['AIMS: Recent evidence supports the activation of mechanisms underlying cellular ageing and neurodegeneration in developmental lesions associated with epilepsy.', 'Sections were processed for immunohistochemistry using markers for the evaluation of caspase-3 and neurodegeneration-related proteins/pathways and their expression was correlated with the tumour features and the clinical history of epilepsy.', 'CONCLUSIONS: Our observations in GNT provide evidence of premature activation of mechanisms of neurodegeneration which are associated with the clinical course of epilepsy in patient with GG.'], ['Osteoarthritis (OA) is a chronic degenerative disease leading to aberrance of cartilage structures with unclear or multifactorial mechanisms.'], ['Alzheimer disease, a progressive neurodegenerative disorder, is the most common cause of dementia in the elderly.'], ['Large-scale mitochondrial DNA (mtDNA) deletions are an important cause of mitochondrial disease, while somatic mtDNA deletions cause focal respiratory chain deficiency associated with ageing and neurodegenerative disorders.'], ['Protein degradation is a regulatory process essential to cell viability and its dysfunction is implicated in many diseases, such as aging and neurodegeneration.'], ["Alzheimer's disease (AD) is an incapacitating neurodegenerative disease that slowly destroys brain cells."], ['It has been proposed that a cascade of events including mitochondrial dysfunction, impaired insulin signaling, and metabolic inflammation trigger neurodegeneration in T2DM models.'], ["BACKGROUNDS/OBJECTIVE: Parkinson's disease (PD) is the second most common neurodegenerative disease among the elderly population."], ['To explore the experiences of recruiting care homes and research participation, interviews were conducted with researchers working for the Dementia and Neurodegenerative Diseases Research Network (DeNDRoN) and care home managers.'], ['OBJECTIVE: To test the hypotheses predicted in a hypothetical model of Alzheimer disease (AD) biomarkers that rates of beta-amyloid (Abeta) accumulation on PET imaging are not related to hippocampal neurodegeneration whereas rates of neurodegenerative brain atrophy depend on the presence of both amyloid and neurodegeneration in a population-based sample.', 'RESULTS: At baseline, 148 (59%) were amyloid negative and neurodegeneration negative (A-N-), 29 (12%) amyloid negative and neurodegeneration positive (A-N+), 56 (22%) amyloid positive and neurodegeneration negative (A+N-), and 19 (8%) amyloid positive and neurodegeneration positive (A+N+).', 'High rates of Abeta accumulation were found in those with abnormal amyloid at baseline and were not influenced by hippocampal neurodegeneration at baseline.', 'First, the rate of Abeta accumulation is not influenced by neurodegeneration and thus may be a biologically independent process.', 'Second, Abeta pathophysiology increases or catalyzes neurodegeneration.'], ['However, the precise mechanisms connecting DNA damage with neurodegeneration remain poorly understood.'], ['Furthermore, recent studies have shown that autophagy is critical in wide range of normal human physiological processes, and defective autophagy is associated with diverse diseases, including lysosomal storage disease, myopathies, neurodegeneration and various metabolic disorders.'], ['Thus, evaluating proteins and pathways that are important in age-related neurodegeneration in the developing brain together with the characterization of mechanisms important during brain development with relevance to brain aging are of crucial importance.', 'In the present review we focus on (1) aspects of neurogenesis with relevance to aging; (2) neurodegenerative disease (NDD)-associated proteins/pathways in the developing brain; and (3) further pathways of the developing or neurodegenerating brains that show commonalities.'], ['Aging is a primary risk factor for neurodegenerative disease (ND), and a common assumption has arisen that leukocyte telomere length (LTL) can serve as a predictor of neurological disease.', 'Additional research is needed to determine whether neuronal and glial telomeres shorten during aging and in neurodegenerative disorders, if and how LTL is related to brain cell telomere shortening, and whether telomere shortening plays a causal role in or exacerbates neurological disorders.'], ['This multidisciplinary approach links human evolution with health and provides a complementary perspective on aging and neurodegenerative disease that may help identify key mechanisms and targets for intervention.'], ['Many of the aging-related morbidities, including cancer, cardiovascular disease, neurodegenerative disease, and infectious susceptibility, are linked to a decline in immune competence with a concomitant rise in proinflammatory immunity, placing the process of immune aging at the center of aging biology.'], ["Alzheimer's disease (AD) is a major neurodegenerative disease affecting the elderly."], ['OBJECTIVE: Cardiovascular comorbidities associate with neurodegeneration in the elderly and may contribute to extranigral pathologies and medically refractory axial motor features in Parkinson disease (PD).'], ['Human neurons are functional over an entire lifetime, yet the mechanisms that preserve function and protect against neurodegeneration during ageing are unknown.', 'Moreover, REST potently protects neurons from oxidative stress and amyloid beta-protein toxicity, and conditional deletion of REST in the mouse brain leads to age-related neurodegeneration.', 'Thus, the activation state of REST may distinguish neuroprotection from neurodegeneration in the ageing brain.'], ['In the current work, we review the current knowledge about oxidative stress in AD pathogeny and we suggest future paths that are worth to be explored in animal models and clinical studies, in order to get a better approach of oxidative imbalance in this inexorable neurodegenerative disease.'], ['These challenges require expertise in neurodegenerative disorders and geriatrics.'], ["Age-related cognitive decline is a main predictor of disability among elderly people, and with the continued expansion of the aging population and the increase in life expectancy, the prevalence of mild cognitive impairment and dementia represented by Alzheimer's disease (AD), which is a multifactorial neurodegenerative disorder of older adults, have increased."], ['However, a multi-target approach using combinations of (micro)nutrients might have beneficial effects on cognitive function in neurodegenerative brain disorders like AD leading to synaptic degeneration.'], ['Neurodegenerative disorders of aging represent a growing public health concern.', 'Methods such as epigenetic reprogramming of patient skin fibroblasts to human induced pluripotent stem cells, which can be differentiated into patient-derived neuron subtypes, have generated significant excitement because of their potential to model more accurately aspects of human neurodegeneration.'], ['Excess body weight and adiposity cause insulin resistance, inflammation, and numerous other alterations in metabolic and hormonal factors that promote atherosclerosis, tumorigenesis, neurodegeneration, and aging.'], ["Alzheimer's disease is a progressive neurodegenerative disorder that leads to dementia mainly among the elderly."], ["REM sleep behavior disorder (RBD) appears to have a predilection for some neurodegenerative disorders, especially synucleinopathies such as Parkinson's disease (PD), dementia with Lewy bodies and multiple system atrophy.", 'Idiopathic RBD may foreshadow neurodegenerative diseases, and RBD in patients with PD has several associated clinical factors although their causal or temporal relationships are not known.', 'This review will address the clinical implications of RBD as a preclinical marker of neurodegenerative diseases and PD phenotypes associated with RBD.'], ['PGC-1alpha and mtTFA), are candidates for therapeutic intervention in diverse diseases, like neurodegenerative disorders, metabolic syndrome, sarcopenia, cardiac pathophysiology and physiological processes like aging.'], ['It has been reported that cocoa phytochemicals specifically modulate or interact with specific molecular targets linked to the pathogenesis of chronic human diseases, including cardiovascular diseases, cancer, neurodegenerative diseases, obesity, diabetes, and skin aging.'], ["Functional brain imaging studies have demonstrated reduced task-induced deactivation (TID) of the brain's default mode network (DMN) in a wide range of neurodegenerative diseases involving cognitive symptoms, in conditions with increased risk of Alzheimer's disease, and even in advanced but healthy aging."], ['The increase in BDNF might reflect a compensatory mechanism against early neurodegeneration and seems to be related to inflammation.'], ['Along with this increase the number of age related diseases, such as cardiovascular, neurodegenerative diseases, metabolic impairment and cancer, is also on the rise thereby negatively impacting the burden on health care systems.'], ['Induction of autophagy is also associated with rescue of the tauopathy phenotype, suggesting that formation of GABs may be a compensatory mechanism rather than a trigger of neurodegeneration.', 'Collectively, these data indicate that autophagic gridlock contributes to the development of pathology in aging and neurodegeneration.'], ['In the context of ageing and chronic neurodegeneration, adaptive changes to acute insults are characterized by exaggerated production of pro-inflammatory cytokines by primed microglia coupled with dysfunction of brain-to-immune pathways.'], ['The manifestation of behavioral alterations and learning and memory deficits develop since the fourth week of age, i.e., simultaneously with first signs of neurodegeneration detectable on magnetic resonance imaging and under a light microscope.'], ['Further, TBI can act as a conduit to longer term neurodegenerative disorders.', "Prior studies of glucagon-like peptide-1 (GLP-1) and long-acting GLP-1 receptor agonists have demonstrated neurotrophic/neuroprotective activities across a broad spectrum of cellular and animal models of chronic neurodegenerative (Alzheimer's and Parkinson's diseases) and acute cerebrovascular (stroke) disorders."], ['During past decades, ever-increasing life expectancy, despite the development of a sedentary lifestyle and altered eating habits, has led to a dramatic parallel increase in the prevalence of age-related diseases such as type 2 diabetes mellitus (T2DM) and neurodegenerative disorders.', "Converging evidence from animal and human studies has indicated that insulin resistance in the central nervous system (CNS) is observed in both T2DM and neurodegenerative disorders such as Alzheimer's disease (AD), leading to the hypothesis that impaired neuronal insulin action might be a unifying pathomechanism in the development of both diseases.", 'We also discuss mechanisms and clinical outcomes of neuronal insulin resistance and address the seeming paradox of how impaired neuronal IIS can protect from the development of neurodegenerative disorders.'], ["Aging is the major risk factor for the development of human neurodegenerative maladies such as Alzheimer's, Huntington's and Parkinson's diseases, and prion disorders, all of which stem from toxic protein aggregation.", 'Here we review the recent advances in the field, describe the known mechanistic links between toxic protein aggregation, neurodegenerative disorders and the aging process and delineate recent studies that point at IGF1 signalling inhibitors as promising therapies for the treatment of various late-onset neurodegenerative disorders.'], ['Mitochondria contain their own DNA (mtDNA) with genomic variants that have different physiological and pathological characteristics, including susceptibility to neurodegeneration.'], ['Whether this is a result of active HIV-related neurodegeneration is unclear.'], ['Oxidative stress plays a key role in late onset diseases including cancer and neurodegenerative diseases such as Huntington disease.', 'Indeed, the nuclear factor erythroid 2-related factor 2 (NRF2), a master regulator of the cellular antioxidative stress response, is deregulated in both cancer and neurodegeneration.', 'Similar to NRF2, the tumor suppressor Homologous to the E6-AP Carboxyl Terminus (HECT) domain and Ankyrin repeat containing E3 ubiquitin-protein ligase 1 (HACE1) plays a protective role against stress-induced tumorigenesis in mice, but its roles in the antioxidative stress response or its involvement in neurodegeneration have not been investigated.', 'These findings reveal that the tumor suppressor HACE1 plays a role in the NRF2 antioxidative stress response pathway and in neurodegeneration.'], ['IMPORTANCE: Alzheimer disease (AD) is a neurodegenerative disorder with no effective therapies.'], ['The mechanisms through which HIV and aging lead to neurodegeneration include: abnormal calcium flux, excitotoxicity, signaling abnormalities, oxidative stress and autophagy defects.', 'Recent evidence implicates alterations in neurotrophins in the pathogenesis of neurodegeneration associated with HAND in the context of aging.'], ['However, Nrf2 signalling is impaired in several aging-related diseases, such as chronic pulmonary obstructive disease (COPD), cancer, and neurodegenerative diseases.'], ['Oxidative stress including DNA damage, increased lipid and protein oxidation, are important features of aging and neurodegeneration suggesting that endogenous antioxidant protective pathways are inadequate or overwhelmed.', 'In addition, environmental toxins such as rotenone and paraquat, which are risk factors for the pathogenesis of neurodegenerative diseases, also promote protein oxidation.', 'These could include: (1) radical scavenging antioxidants cannot reverse established damage to proteins and organelles; (2) radical scavenging antioxidants are oxidant specific, and can only be effective if the specific mechanism for neurodegeneration involves the reactive species to which they are targeted and (3) since reactive species play an important role in physiological signaling, suppression of endogenous oxidants maybe deleterious.', 'While not previously considered an antioxidant system we propose that the autophagy-lysosomal activities, may serve this essential function in neurodegenerative diseases by removing damaged or dysfunctional proteins and organelles.'], ['As other research has linked the presence of OSA to a higher likelihood of developing dementia, future studies are necessary to examine if the inhibition of memory consolidation is tied to the onset of neurodegenerative disease.'], ['When supra-patellar bursitis is caused by degenerative disorders, the concept of viscosupplementation treatment may be effective by injecting hyaluronic acid into the bursa.'], ["Alzheimer's disease (AD) is a neurodegenerative disorder characterized by progressive decline in multiple cognitive domains and it becomes the most common cause of dementia in the elderly."], ["S-nitrosylation of the active site of PDI inhibits the PDI activity and links protein misfolding to neurodegenerative diseases like Alzheimer's and Parkinson's diseases.", 'FUTURE DIRECTIONS: The correct oxidative protein folding is critical for the substrate protein stability and function, and protein misfolding is linked to, for example, neurodegenerative diseases.', 'Further understanding on the mechanisms and specific roles of Trx superfamily proteins in oxidative protein folding may lead to drug development for the treatment of bacterial infection and various human diseases in aging and neurodegeneration.'], ['Imaging of the brain provides evidence of neurodegeneration in elderly patients; however, abnormalities in brain structure and their relation to POCD are uncertain.'], ['Several lines of evidence suggest that insulin signalling dysfunction produces these metabolic alterations and underlie the development of these neurodegenerative diseases.', 'The comprehensive knowledge of the molecular mechanisms behind the association of metabolic alterations and cognitive impairment could facilitate the early detection of neurodegenerative diseases in patients with metabolic alterations, with treatment that focus on neuroprotection.'], ['Cerebral amyloid angiopathy (CAA) is a common degenerative disease presenting intracerebral hemorrhage (ICH) in older people.', 'Uric acid (UA) is a natural antioxidant, and may have a beneficial role in neurodegenerative diseases.'], ['Afterwards, we will focus on the relationships linking various biological and lifestyle factors - such as nutrition - that are crucial to obtain a comprehensive picture of ageing and to promote preventing strategies against degenerative neurological diseases.'], ["In the past two decades research has highlighted how implicit memory processes are spared in degenerative disorders, such as Alzheimer's disease (AD), which are characterized by the early onset of explicit memory deficits."], ['In rodents intermittent or periodic fasting protects against diabetes, cancers, heart disease, and neurodegeneration, while in humans it helps reduce obesity, hypertension, asthma, and rheumatoid arthritis.'], ["Neurodegenerative diseases, Alzheimer's disease (AD) and Parkinson's disease (PD), constitute a major worldwide health problem.", 'Notably, copper dyshomeostasis has been shown to underlie the pathophysiology of several neurodegenerative diseases including AD and PD.'], ['Supplementation with Vitamin E can restore the balance and protect against the deteriorating effects of oxidative stress, progression of degenerative diseases, and aging.'], ['Research into mitochondria and cell function has revealed that mitochondrial dynamics is impaired in a large number of aging and neurodegenerative diseases, and in several inherited mitochondrial diseases, and that this impairment involves excessive mitochondrial fission, resulting in mitochondrial structural changes and dysfunction, and cell damage.'], ["Parkinson's disease (PD) is the second most common neurodegenerative disorder.", 'Interestingly, the response to stress conditions and quality control mechanisms is impaired in PD, as well as in other neurodegenerative disorders.', 'Altered rRNA transcription and disruption of nucleolar integrity are associated with neurodegenerative disorders, and with aging.', 'Nucleolar stress can be triggered by genetic and epigenetic factors, and by specific signaling mechanisms, that are altered in neurodegenerative disorders.', 'Emphasis is given to similarities in molecular causes and consequences of nucleolar stress in other neurodegenerative disorders.', 'The mechanisms by which nucleolar stress participates in PD could help identify novel risk factors, and develop new therapeutic strategies to slow down the progressive loss of neurons in neurodegenerative diseases.'], ["Alzheimer's disease (AD) is a neurodegenerative disorder and the most common cause of dementia in the elderly."], ['In humans, aberrant expression of eIF4G is associated with certain forms of cancer and neurodegeneration.'], ['Therefore, quantitative real-time polymerase chain reaction was used to determine the genomic content of rDNA in post mortem samples of parietal cortex from 14 young and 9 elderly individuals with no diagnosis of a chronic neurodegenerative/neurological disease.', 'In addition, rDNA content in that brain region was compared between 10 age-matched control individuals and 10 patients with dementia with Lewy bodies (DLB) which involves neurodegeneration of the cerebral cortex.', "As increased cerebro-cortical rDNA content was previously reported in Alzheimer's disease, neurodegeneration appears to be associated with instability of rDNA."], ["Parkinson's Disease is the second most common progressive neurodegenerative disorder affecting older American adults and is predicted to increase in prevalence as the United States population ages."], ['Many neurodegenerative disorders, diabetes, cancer, fibromyalgia, muscular and cardiovascular diseases have been associated with low CoQ10 levels.'], ['Less known is a new body of research to be discussed in this review, suggesting that ALDH2 dysfunction may contribute to a variety of human diseases including cardiovascular diseases, diabetes, neurodegenerative diseases, stroke, and cancer.'], ["Physical exercise that targets modifiable risk factors and neuroprotective mechanisms may reduce declines in cognitive performance attributed to the normal aging process and protect against changes related to neurodegenerative diseases such as Alzheimer's disease and other types of dementia."], ['The universal Social Security of Costa Rica aspires to develop national screening of neurodegenerative disorders among the elderly, as part of the non-communicable disease agenda.'], ['It is well established that the risk to develop neurodegenerative disorders increases with chronological aging.'], ['OBJECTIVE: The older person is more likely to have pain since degenerative diseases and the effects of cancer are more common after 65 years of age.'], ['OBJECTIVES: We determined whether head trauma was associated with amyloid deposition and neurodegeneration among individuals who were cognitively normal (CN) or had mild cognitive impairment (MCI).'], ['BACKGROUND: Statistical models of normal ageing brain tissue volumes may support earlier diagnosis of increasingly common, yet still fatal, neurodegenerative diseases.', 'This suggests that percentile rank estimates will be required to robustly define the limits of brain tissue volume in normal ageing and neurodegenerative disease.'], ['Considering that Cp can undergo oxidative modifications in the CSF of neurodegenerative diseases, we investigated the effect of oxidation on the deamidation of both NGR motifs and, consequently, on the acquisition of integrin binding properties.'], ['Mouse lines with impaired mitochondrial activity had critically short life spans or severe and rapidly progressing neurodegeneration.'], ['OBJECTIVE: Methylglyoxal (MG), a reactive carbonyl compound formed primarily from triose phosphates, appears to be involved in the molecular mechanisms of diabetes, end-stage renal disease and neurodegenerative diseases.'], ["Inflammatory mechanisms are activated in aging and late-onset neurodegenerative diseases, such as Parkinson's disease (PD)."], ['Of these, 4 patients showed neurological deterioration associated with HARM.'], ['Age-associated ventriculomegaly is typically attributed to neurodegeneration; however, additional factors might initiate or contribute to progressive ventricular expansion.', 'To examine whether loss of ependymal cell coverage resulting in ventricle surface glial scarring can lead directly to ventricle enlargement independent of any other injury or degenerative loss, we modeled in mice the glial scarring found along the lateral ventricle surface in aged humans.', '3D modeling together with volume measurements revealed that mice with ventricle surface scarring developed expanded ventricles, independent of neurodegeneration.'], ['Many clinical and animal studies demonstrate the importance of long-chain polyunsaturated fatty acids (LCPUFA) in neural development and neurodegeneration.', "Last, we will focus on the role of LCPUFA in most common neurodegenerative diseases like Alzheimer's disease and Parkinson's disease.", 'These disorders are characterized by impaired cognition and connectivity and both clinical and animal supplementation studies have shown the potential of LCPUFA to decrease neurodegeneration and inflammation.'], ['Diet in particular has become the object of intense research in relation to cognitive aging and neurodegenerative disease.'], ['Mitochondrial dysfunction is implicated in neurodegeneration and ageing.', 'Relative mitochondrial to cytoplasmic ratios of Hba and Hbb show changing distributions of these proteins during the process of neurodegeneration in the pcd(5j) mouse brain.'], ["OBJECTIVES: Detecting very early markers of neurodegeneration that predate the diagnosis of idiopathic Parkinson's disease (PD) is a crucial research topic for the development of disease-modifying therapeutic interventions."], ['Neurodegeneration, the progressive dysfunction and loss of neurons in the central nervous system (CNS), is the major cause of cognitive and motor dysfunction.', 'The adaptive immune response is implicated in neurodegenerative diseases contributing to tissue damage, but also plays important roles in resolving inflammation and mediating neuroprotection and repair.', 'The growing awareness that the immune system is inextricably involved in mediating damage as well as regeneration and repair in neurodegenerative disorders, has prompted novel approaches to modulate the immune system, although it remains whether these approaches can be used in humans.'], ['SIRT1 overexpression or activation is protective in neurodegenerative diseases.'], ['Studies have demonstrated that microRNAs (miRNAs) play an important role in the regulation of brain development and have a significant impact on brain aging and neurodegeneration.'], ['Old age (>= 75 years) was not associated with neurological deterioration (multivariate-adjusted odds ratio [OR] 0.90, 95% confidence interval [CI] 0.46-1.77), neurological improvement (multivariate-adjusted OR 0.91, 95% CI 0.54-1.53) and symptomatic intracranial hemorrhage (multivariate-adjusted OR 1.11, 95% CI 0.19-8.87).'], ["The immaturity of neurons differentiated from human induced pluripotent stem cells (hiPSCs) presents difficulties for modeling late-onset neurodegenerative disorders such as Parkinson's disease.", '(2013) provide a strategy for inducing aging-related phenotypes in hiPSC-derived neurons, enabling in vitro study of late-onset neurodegenerative diseases.'], ['Exclusion criteria were comorbidities such as physical, psychological, psychiatric or neurodegenerative diseases at the beginning of the study.'], ['CONCLUSION: The association of global WMHs with lower GM volume and higher ventricular volume is independent of age, VRFs and APOE-epsilon4 allele, suggesting that the process of cerebral microvascular disease and neurodegeneration are associated independently of the normal aging process, vascular mechanisms or genetic susceptibility.'], ["Granulovacuolar degeneration (GVD) bodies are spherical vacuoles containing argentophilic and hematoxyphilic granules, and are one of the pathological hallmarks commonly found in hippocampal pyramidal neurons of patients with aging-related neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease."], ['Molecular mechanisms underlying neurodegenerative diseases converge at the interface of pathways impacting cellular stress, protein homeostasis and aging.'], ['Mitochondrial, and more specifically bioenergetic, malfunction is commonly encountered in cancer, degenerative disorders and aging.'], ['PD is the second most common neurodegenerative disorder after Alzheimer disease (AD) and is expected to become progressively more prevalent in our aging societies.'], ['In these subjects brain(18)F-FDG PET is regarded as a reliable biomarker of neurodegeneration.'], ['Changes in brain-derived neurotrophic factor (BDNF) level are implicated in the pathophysiology of cognitive decline in depression and neurodegenerative disorders in older adults.'], ['Although VP is most often associated with degenerative joint disease, it is observed with other pathologies.'], ['Here, we describe recent advances in the understanding of the molecular dynamics, regulation and physiology of CMA, and discuss the evidence in support of the contribution of CMA dysfunction to severe human disorders such as neurodegeneration and cancer.'], ['Similarly, defective myoproteostasis is described as an important contributor to the pathology of several age-related degenerative muscle diseases in humans, e.g., inclusion body myositis.'], ['Parkinson disease is the second most neurodegenerative disease, after Alzheimer disease, that affects up to two million Americans, the overwhelming majority of whom are aged 60 and older.'], ['Brain iron levels are increased with age-related degenerative diseases, but it is not known if this is the cause or a consequence of the disease, and genetic factors are likely to play a role.'], ['Olfactory dysfunction, which can be defined as conductive, sensorineural, or central (typically related to neurodegenerative disorders), is a clinically significant problem, with a high burden on quality of life that is likely to grow in prevalence due to demographic shifts and increased environmental exposures.'], ['Both cellular systems responsible for clearance of misfolded and aggregated proteins, the lysosomal and the proteasomal, have been shown to be malfunctioning in the aged brain and more so in patients with neurodegenerative diseases, including AD.', 'Taken together, this study suggests that a decrease in proteasome activity can, through activation of c-Jun and ERK 1/2, result in several events related to neurodegenerative diseases.', 'Restoration of proteasome activity or modulation of ERK 1/2 and c-Jun function can open new treatment possibilities against neurodegenerative diseases such as AD.'], ["Alzheimer's is a crippling neurodegenerative disease that largely affects aged individuals."], ['Parkinson disease is a prevalent progressive neurodegenerative disorder, especially in western countries and among the elderly.'], ['Down syndrome (DS) is one of the most common genetic causes of intellectual disability characterized by multiple pathological phenotypes, among which neurodegeneration is a key feature.', 'It is reasonable to suggest that changes in the cellular redox status in DS neurons, early from the fetal period, could provide a fertile environment upon which increased aging favors neurodegeneration.'], ['Here we question this assumption by highlighting experimental evidence in support of the alternative hypothesis suggesting that APP and Abeta are part of a neuronal stress/injury system, which is up-regulated to counteract inflammation/oxidative stress-associated neurodegeneration that could be triggered by a brain injury, chronic infections, or a systemic disease.'], ["Subjects with stroke or neurodegenerative diseases other than Alzheimer's disease were excluded."], ['OBJECTIVE: We investigated whether, and the extent to which, vascular and degenerative lesions in the brain mediate the association of diabetes with poor cognitive performance.', 'The association is largely mediated by markers of both neurodegeneration and cerebrovascular disease.'], ['Different topics are covered including disorders related to neural accumulation of iron (i.e., syndromes of neurodegeneration with brain iron accumulation), manganese, copper, or calcium.'], ['Due to the smaller size, greater permeability, increased circulation ability and biocompatibility of these nanoparticles to alleviate oxidative stress, they have become indispensable agents for controlling aging and its associated pathologies, including neurodegenerative diseases, cardiovascular diseases, and pulmonary diseases.'], ['METHODS: Cross-sectional study of 1,649 community-dwelling men aged 80 years or over with no history of terminal illnesses or neurodegenerative diseases.'], ['Decline of cognition and increasing risk of neurodegenerative diseases are major problems associated with aging in humans.', 'Glymphatic dysfunction may pay a hitherto unsuspected role in the pathogenesis of neurodegenerative diseases as well as maintenance of cognition.', 'Further characterization of the glymphatic system in humans may lead to new therapies and methods of prevention of neurodegenerative diseases.'], ['With estimates of dementia expected to rise over the coming decades, there is interest in understanding the factors associated with promoting neuroprotection and limiting neurodegeneration.'], ["PARKINSON'S DISEASE (PD) is the second most common neurodegenerative disorder to affect older adults, after Alzheimer's disease."], ['The recent evidences indicate that autophagy is associated with a number of pathological processes including cancer, muscular disorder and neurodegeneration in addition to longevity.'], ['Such apparently irrelevant immune activity unprovoked by an exogenous infectious agent characterizes the aging brain and is even more pronounced in several neurodegenerative diseases.'], ['PURPOSE OF REVIEW: We present an overview of recent concepts in mechanisms underlying cognitive decline associated with brain aging and neurodegeneration from the perspective of MRI.', 'RECENT FINDINGS: Recent findings challenge the established link between neuroimaging biomarkers of neurodegeneration and age-related or disease-related cognitive decline.', "Studies suggesting that imaging biomarkers of neurodegeneration are independent of amyloid-beta give rise to new hypothesis regarding the pathological cascade in Alzheimer's disease.", "Findings in patients with autosomal-dominant Alzheimer's disease confirm the notion of differential temporal trajectory of amyloid deposition and brain atrophy to add another layer of complexity on the basic mechanisms of cognitive aging and neurodegeneration.", 'SUMMARY: Recent advances in clinical neuroscience, brain imaging and genetics challenge pathophysiological hypothesis of neurodegeneration and cognitive aging dominating the field in the last decade and call for reconsidering the choice of therapeutic window for early intervention.'], ['We find that these supersaturated proteins represent a metastable subproteome involved in pathological aggregation during stress and aging and are overrepresented in biochemical processes associated with neurodegenerative disorders.', 'Thus, the simultaneous analysis of abundance and solubility can rationalize the diverse cellular pathologies linked to neurodegenerative diseases and aging.'], ['Increasing evidence shows that oxidative stress is associated with the pathogenesis of diabetes, obesity, cancer, ageing, inflammation, neurodegenerative disorders, hypertension, apoptosis, cardiovascular diseases, and heart failure.'], ['This review discusses recently available data about CyPA in cardiovascular diseases, viral infections, neurodegeneration, cancer, rheumatoid arthritis, sepsis, asthma, periodontitis and aging.'], ['AGEs have been proposed to be among the main intermediaries involved in several diseases, such as metabolic syndrome, type 2 diabetes mellitus, cardiovascular disease, ovarian aging, inflammation, neurodegenerative disorders and PCOS.'], ['We propose that strong brainstem expression of Apo D throughout adult life contributes to resistance against neurodegenerative disease and age-related degeneration, possibly by preventing oxidative stress and ensuing lipid peroxidation.'], ['IMPORTANCE: Criteria for preclinical Alzheimer disease (AD) propose beta-amyloid (Abeta) plaques to initiate neurodegeneration within AD-affected regions.', 'OBJECTIVE To examine relationships between Abeta and non-Abeta factors as well as neurodegeneration within AD regions in cognitively normal older adults.', 'The study quantified neurodegenerative abnormalities using imaging biomarkers and examined cross-sectional relationships with Abeta deposition; white matter lesions (WMLs), a marker of cerebrovascular disease; and cognitive functions.', 'MAIN OUTCOMES AND MEASURES: For each individual, 3 AD-sensitive neurodegeneration biomarkers were measured: hippocampal volume, glucose metabolism, and gray matter thickness, the latter 2 sampled from cortical AD-affected regions.', 'To quantify neurodegenerative abnormalities, each biomarker was age adjusted, dichotomized into a normal or abnormal status (using cutoff thresholds derived from an independent AD sample), and summarized into 0, 1, or more than 1 abnormal neurodegenerative biomarker.', 'Degree and topographic patterns of neurodegenerative abnormalities were assessed and their relationships with cognitive functions, WML volume, and Abeta deposition (quantified using carbon 11-labeled Pittsburgh compound B positron emission tomography).', 'RESULTS: Of our cognitively normal elderly individuals, 40% (n = 29) displayed at least 1 abnormal neurodegenerative biomarker, 26% (n = 19) of whom had no evidence of elevated Pittsburgh compound B retention.', 'In those people who were classified as having abnormal cortical thickness, degree and topographic specificity of neurodegenerative abnormalities were similar to patients with AD.', 'Accumulation of neurodegenerative abnormalities was related to poor memory and executive functions as well as larger WML volumes but not elevated Pittsburgh compound B retention.', 'CONCLUSIONS AND RELEVANCE: Our study confirms that a substantial proportion of cognitively normal older adults harbor neurodegeneration, without Abeta burden.', 'Associations of neurodegenerative abnormalities with cerebrovascular disease and cognitive performance indicate that neurodegenerative pathology can emerge through non-Abeta pathways within regions most affected by AD.'], ['AMD (age-related macular degeneration) is a neurodegenerative disease causing irreversible central blindness in the elderly.'], ["Parkinson's disease (PD) is a degenerative disorder commonly seen in the elderly, characterized by movement disorders including tremor, akinesia, and loss of postural reflexes."], ['INTRODUCTION: In the last decades the demographics of most Western countries have undergone a deep transformation, which has caused a steady increase in degenerative chronic diseases and has made maintaining health and social support by the welfare system difficult.'], ['Over 300 mutations in the LMNA gene, encoding A-type lamins, are associated with 15 human degenerative disorders and premature aging syndromes.'], ['Accumulation of mitochondrial DNA (mtDNA) mutations has been implicated in a wide range of human pathologies, including neurodegenerative diseases, sarcopenia, and the aging process itself.'], ['Reduced heart rate variability is a strong predictor of cardiovascular risk factors, cardiovascular events, and mortality and thus may be associated with cognitive neurodegeneration.'], ['IHC studies revealed that site-specific overexpression of the hTDP-43 transgene in colonic myenteric plexes resulted in progressive neurodegeneration in this region.', 'While this model may be useful for studying GI tract neurodegeneration, in its present state it does not display a phenotype suitable for testing ALS therapeutics.'], ["Mitochondrial dysfunction occurs early in the course of several neurodegenerative diseases, and is potentially related to increased oxidative damage and amyloid-beta (Abeta) formation in Alzheimer's disease."], ['BACKGROUND: Abdominal aortic aneurysm (AAA) is a complex degenerative disease, which leads to morbidity and mortality in a large portion of the elderly population.'], ['The knowledge thereby generated can be used to develop more targeted rehabilitation approaches, efficient housing adaptation services and societal planning for people with neurodegenerative disorders.'], ['We review findings on neuroplasticity in the aging brain and their relevance for cognitive improvement in patients with neurodegenerative diseases.'], ['Dementia and gait impairments often coexist in older adults and patients with neurodegenerative disease.'], ['OBJECTIVE: To test the hypothesis that neurodegeneration and neuronal density in brainstem aminergic nuclei are related to late-life depressive symptoms.'], ['However, 11/26 (42%) incident amyloid-positive subjects had evidence of neurodegeneration prior to incident amyloid positivity.', 'These 11 could be subjects with combinations of preexisting non-Alzheimer pathophysiologies and tau-mediated neurodegeneration who newly entered the amyloid pathway.', 'Our findings suggest that both "amyloid-first" and "neurodegeneration-first" biomarker profile pathways to preclinical AD exist.'], ['This occurs in patients with advanced heart disease and subsequent heart failure refractory to treatment but also in a patient with an ICD who develops cancer disease, organ failure or other neurodegenerative diseases with poor short-term prognosis.'], ['However, there is currently no neuroimaging evidence to suggest that lifelong bilinguals can retain normal cognitive functioning in the face of age-related neurodegeneration.'], ['However, fluoroquinolone prophylaxis has already been associated with the emergence and spread of resistant bacteria and strictly precludes the subsequent use of fluoroquinolones for initial empirical therapy; in addition, fluoroquinolones should be administered with caution among elderly patients, especially those with more pronounced vascular or degenerative impairment of the central nervous system, cardiac disease or electrolyte disturbances.'], ['BACKGROUND: The global trend of increased life expectancy and increased prevalence of chronic and degenerative diseases will impact on health systems.'], ['These isoforms are ubiquitously expressed in the tissues, and have been implicated in aging, neurodegenerative disorders, cancer progression, and metabolic/cardiovascular diseases including dyslipidemia, diabetes, atherosclerosis and myocardial infarction.'], ['BACKGROUND: Aging and neurodegenerative disease predispose to delirium and are both associated with increased activity of the innate immune system resulting in an imbalance between pro- and anti-inflammatory mediators in the brain.'], ['Our imaging-genetics analysis in a large dataset suggests that while BDNF genetic variation is not specifically associated with a diagnosis of AD, it appears to play a role in AD-related brain neurodegeneration.'], ['Aging is accompanied with several degenerative disorders including cardiovascular, neuronal and metabolic diseases.'], ['Age-specific gene expression plays an important role in several critical events in brain development, including neuronal cell migration, synaptogenesis and neurotransmitter receptor specificity, as well as in aging and neurodegenerative disorders (e.g., Alzheimer disease or amyotrophic lateral sclerosis).'], ['The link between brain iron homeostasis and neurodegenerative disease has been the subject of extensive research.', 'There is increasing evidence of iron accumulation during ageing, and altered iron levels in some specific brain regions in neurodegenerative disease patients have been reported.'], ['Alzheimer disease (AD) is the most common form of dementia and characterized by deposition of amyloid-beta (Abeta) plaques, neurofibrillary tangles consisting of hyperphosphorylated tau, atrophy, and progressive neurodegeneration.'], ['Understanding the effect of aging on MSCs is crucial for both autologous therapy development and allogenic donors in older subjects whom degenerative diseases typically afflict.'], ['Increased neuroinflammation, as measured with [(18)F]-FEPPA PET was not associated with normal aging, suggesting that healthy elderly individuals may serve as useful benchmark against patients with neurodegenerative disorders where neuroinflammation may be present.'], ['We provide a "pragmatic drug repurposing score" for each of these compounds based on type of studies conducted, number of possible mechanisms of action, efficacy in AD and other neurodegenerative disease studies, tolerability profile, and their ability to cross the blood brain barrier.'], ['However, the function of LRG in the brain during aging and neurodegenerative diseases has not been investigated.', 'Accumulation of LRG in the brains of PDD and PSP patients is not a primary etiological factor, but it is thought to be one of the causes of neurodegeneration.'], ["However, age is the main risk factor for neurodegenerative disorders such as Alzheimer's disease (AD) that impact on cognition."], ["BACKGROUND: Gray matter atrophy is regarded as a valid marker of neurodegeneration in Alzheimer's disease (AD), but few studies have investigated in detail the topographic changes associated with normal aging."], ['The findings provide evidence for the large-scale network model of neurodegenerative disease, in which neurodegeneration spreads through intrinsically connected brain networks in a disease specific manner.'], ['Amyotrophic lateral sclerosis (ALS) is a severe neurodegenerative disease principally affecting motor neurons.'], ['No surviving patient had neurological deterioration postoperatively.'], ['Amyotrophic lateral sclerosis (ALS) is a fatal progressive neurodegenerative disorder.'], ['Two of the key areas in which diet is thought to play an important role are in optimizing neurodevelopment in children and in preventing neurodegeneration and cognitive decline during aging.'], ['In an aging society, research involving neurodegenerative disorders is of paramount importance.', 'Here, we provide a brief overview of how flies can be used to analyze molecular mechanisms underlying human neurodegenerative diseases.'], ["Age is one of the key risk factors of several human neurodegenerative disorders such as Alzheimer's disease and Parkinson's disease.", 'We hypothesize that impairment of the brain immunity and BBB integrity can create the optimal condition for viral infection that can further amplify the neuroinflammation mediated by glial cells and neurodegeneration induced and driven by disease modified proteins.'], ['ASCs from older donors failed to ameliorate the neurodegeneration associated with EAE, and mice treated with older donor cells had increased central nervous system inflammation, demyelination, and splenocyte proliferation in vitro compared with the mice receiving cells from younger donors.'], ['An Abeta level relevant to neurodegeneration elicited broad M cytokine and ex-mRNA responses that were significantly greater in the old subjects, but only narrow and age-independent CD4-Tm responses.'], ['Patients with Alzheimer disease (AD) (n=480) or mild cognitive impairment (n=187) and those who were cognitively intact (n=687) were included; patients with stroke or with neurodegenerative diseases other than AD were excluded.'], ['A reduction in mtDNA copy number has been reported in various human pathological conditions such as diabetes, obesity, neurodegenerative disorders, aging and cancer.'], ["In vivo, averaged R2' vs. R2 data points of patients with Parkinson's disease and progressive supranuclear palsy were above the fitted curves of healthy subjects suggesting larger sized iron deposits in these neurodegenerative diseases."], ['We further examine whether meaningful changes in objective sleep physiology are predicted by self-reported sleep measures in MCI patients, and whether incipient neurodegeneration contributes to exacerbate sleep misperception.'], ['Atrophy of the medial temporal lobe (MTL) and basal ganglia (BG) are characteristic of various neurodegenerative diseases in older people.'], ['Here we report the dramatic neuroprotective effect of recombinant human Hsp70 in the bilateral olfactory bulbectomy model (OBX mice) and 5XFAD mouse models of neurodegeneration.', 'These studies demonstrate that exogenous Hsp70 may be a practical therapeutic agent for treatment of neurodegenerative diseases associated with abnormal protein biogenesis and cognitive disturbances, such as AD, for which neuroprotective therapy is urgently needed.'], ["Alzheimer's disease (AD) is the most common neurodegenerative disease that causes dementia in the elderly."], ['Mitochondria are implicated in a variety of degenerative disorders and aging.'], ['Mitochondrial dysfunction is associated with age-related degenerative diseases.', 'Missense mutations in the human Ant1 cause several degenerative diseases which are commonly manifested by fractional mtDNA deletions.'], ['These findings suggest that ApoE4 may increase susceptibility to molecular pathology and modulate the anatomic pattern of neurodegeneration in AD.'], ['Promising indications for use in humans include improving cognition in the elderly and in patients with neurodegenerative disorders.'], ['Diseases including cancer, type 2 diabetes, cardiovascular and immune dysfunction and neurodegeneration become more prevalent as we age, and combined with the increase in average human lifespan, place an ever increasing burden on the health care system.'], ["Alzheimer's disease (AD) is the most common neurodegenerative disorder among older people."], ['The claimed beneficial effects of the Mediterranean diet include prevention of several age-related dysfunctions including neurodegenerative diseases and Alzheimer-like pathology.', 'Our results support, and provide mechanistic insights into, the beneficial effects against Alzheimer-associated neurodegeneration of a polyphenol enriched in the extra virgin olive oil, a major component of the Mediterranean diet.'], ['In humans, age represents risk factor number one for most diseases ultimately leading to death in industrialized countries, namely cardiovascular diseases, cancer and neurodegenerative disorders.'], ['This increase was predominantly localized in close proximity to synapses and occurred earliest and most dramatically in certain regions of the brain, including some but not all regions known to be selectively vulnerable in neurodegenerative diseases, i.e., the hippocampus, substantia nigra, and piriform cortex.'], ['This in turn suggests that peroxisome dysfunction is not only associated with rare inborn errors of peroxisomal metabolism, but also with more common age-related diseases such as neurodegeneration, type 2 diabetes, and cancer.'], ["Alzheimer's disease (AD) is a progressive neurodegenerative disorder of the brain associated with memory impairment, progressive cognitive decline and changes in personality and behavior, with rising incidence among elderly people.", 'Reflecting the world population ageing, the scenario is expected to worsen in the next decades if novel drugs or mechanisms that help to counteract neurodegeneration will not be identified.'], ['In this review, we will discuss both the clinical and the preclinical data related to anesthesia and AD, describe the overlapping pathophysiology of neurodegeneration and provide some insight into the anesthetic care of patients with AD.'], ['CSF biomarkers are consistent with disease trajectories predicted by beta-amyloid cascade (Hardy, J Alzheimers Dis 2006;9(Suppl 3):151-3) and tau-mediated neurodegeneration hypotheses for AD, whereas brain atrophy and hypometabolism levels show predicted patterns but exhibit differing rates of change depending on region and disease severity; (3) the assessment of alternative methods of diagnostic categorization.'], ["INTRODUCTION: Parkinson's disease (PD) is one of the most common neurodegenerative diseases affecting an increasing number of people worldwide with the ageing society."], ['In rhesus monkeys long-term CR reduces the incidence of type 2 diabetes, cardiovascular disease and cancer, and protects against age-associated sarcopenia and neurodegeneration.'], ['Neurodegenerative diseases pose a significant problem for the healthcare system, doctors, and patients.', 'With an aging population, more and more individuals are developing neurodegenerative diseases and there are few treatment options at the present time.', 'Meditation techniques present an interesting potential adjuvant treatment for patients with neurodegenerative diseases and have the advantage of being inexpensive, and easy to teach and perform.', 'There is increasing research evidence to support the application of meditation techniques to help improve cognition and memory in patients with neurodegenerative diseases.', 'This review discusses the current data on meditation, memory, and attention, and the potential applications of meditation techniques in patients with neurodegenerative diseases.'], ['There is intriguing evidence suggesting that protein SQSTM1/p62, together with autophagy, has a role in the pathology of different degenerative diseases.'], ['Animal models have demonstrated that so called enriched environments protect against neurodegenerative diseases, such as dementia.'], ['Cytokines also interfere with neurogenesis during aging and in neurodegenerative diseases.'], ['DNA damage is linked to multiple human diseases, such as cancer, neurodegeneration, and aging.'], ['Parkinson disease (PD) is a multifactorial neurodegenerative disorder with high incidence in the elderly, where environmental and genetic factors are involved in etiology.', 'Here we investigated genome-wide DNA methylation in brain and blood samples from PD patients and observed a distinctive pattern of methylation involving many genes previously associated to PD, therefore supporting the role of epigenetic alterations as a molecular mechanism in neurodegeneration.'], ['Neurodegenerative diseases are characterised by neuronal loss and cerebral deposition of proteins with altered physicochemical properties.', 'During a community-based study we performed comprehensive mapping of neurodegeneration-related proteins and vascular pathology in the brains of 233 individuals (age at death 77-87; 73 examined clinically in detail).'], ['Dysfunction of some sirtuins have been associated with age-related diseases, such as cancer, type II diabetes, obesity-associated metabolic diseases, neurodegeneration, and cardiac aging, as well as the response to environmental stress.'], ['The findings suggest that depressive symptoms in mild dementia could develop due to neurodegeneration in the same neural circuits that are critical for depression across different brain disorders.'], ["Vascular factors are thought to contribute to the development of disease pathology in neurodegenerative dementia such as Alzheimer's disease (AD)."], ["OBJECTIVE: Alzheimer's disease (AD) is a progressive neurodegenerative disorder that affects the corpus callosum (CC), which plays a key role in interhemispheric coupling in high-demand conditions."], ['Accumulating evidence has demonstrated that ROS-modulated autophagy has numerous links to a number of pathological processes, including cancer, ageing, neurodegenerative diseases, type-II diabetes, cardiovascular diseases, muscular disorders, hepatic encephalopathy and immunity diseases.'], ['There is significant oxidative damage in peripheral blood early in the process of neurodegeneration.'], ['We also discuss the PtdIns(3)P effector function of WIPIs in the context of longevity and autophagy-related human diseases, such as cancer and neurodegeneration.'], ['Free radicals and oxidative stress have been recognized as important factors in the biology of aging and in many age-associated degenerative diseases.'], ['The findings suggest that both white matter volume loss and microstructural alterations should be considered more prominently in models of aging and neurodegenerative diseases.'], ["Alzheimer's disease (AD), an age-related neurodegenerative disorder with progressive cognition deficit, is characterized by extracellular senile plaques (SP) of aggregated beta-amyloid (Abeta) and intracellular neurofibrillary tangles, mainly containing the hyperphosphorylated microtubule-associated protein tau."], ['Although HKP is known to be associated with brain injuries and certain neurodegenerative disorders (primarily those involving the frontal lobes and the basal ganglia), an increased tendency to exhibit HKP is also commonly associated with apparently normal aging (i.e., in the absence of known neuropathology).'], ['Adipose tissue dysfunction with obesity is associated with metabolic disease, neurodegeneration, inflammation, and cancer, whereas calorie restriction (CR) decreases both adiposity and disease risk.'], ['Understanding their dynamics in the mammalian allocortex emerges as a critical step to tackle the cellular basis of cognitive decline that occurs during normal aging and in neurodegenerative disorders.'], ['Spontaneous polyploidization arises during stress and has been observed in a variety of pathological conditions, such as cancer and degenerative diseases.'], ['Therefore, it is believed to be the main target of chemical stresses during physiological events such as increased oxidative stress from the degenerative diseases of aging, and higher glucose stress in diabetes mellitus.'], ['This states that accumulation of amyloid beta (Abeta) in the brain triggers a cascade of cellular events leading to neurodegeneration.'], ['Cortical thickness is considered a potentially relevant marker for neurodegenerative diseases.'], ['Human aging is considered as one of the biggest risk factors for the development of multiple diseases such as cancer, type-2 diabetes, and neurodegeneration.'], ['OBJECT: Cervical spondylotic myelopathy (CSM) is a common cervical degenerative disease that affects the elderly population.'], ['With the increase in life expectancy, the improvement of therapeutic arsenal, knowledge and control of chronic degenerative diseases, the world population has reached older age groups.'], ["Alzheimer's disease (AD), which is one of the most common age-associated neurodegenerative disorders, affects millions of people worldwide."], ['Here, we review the current theories of hormetic phenomena in regard to aging and neurodegeneration, with the focus on its underlying mechanism.'], ['OBJECTIVE: To test the hypothesis that the joint presence of beta-amyloidosis and brain injury biomarkers would lead to more rapid neurodegeneration.', 'CONCLUSIONS AND RELEVANCE: Higher rates of medial temporal neurodegeneration occur in CN individuals who, on their initial scans, had abnormal levels of both beta-amyloid and brain injury biomarkers.'], ['Mitochondrial dysfunction has been implicated in numerous human conditions, to include cancer, metabolic diseases, neurodegeneration, diabetes, and aging.'], ["Polymorphisms in SOD2 have been associated with the development of neurodegenerative diseases, such as Alzheimer's and Parkinson's disease, as well as psychiatric disorders, such as schizophrenia, depression and bipolar disorder."], ['Herein, we review the opposing roles of PDGF in the context of HIV-associated neurodegenerative disorder (HAND).'], ['Oxidized bases in DNA have been implicated in cancer, aging and neurodegenerative disease.'], ['AIMS/INTRODUCTION: Glyoxalase 1 catalyses the detoxification of methylglyoxal, a major precursor of advanced glycation end products associated with aging, neurodegenerative diseases, and microvascular complications of diabetes.'], ['INTRODUCTION: Work on human and mouse skeletal muscle by our group and others has demonstrated that aging and age-related degenerative diseases are associated with mitochondrial dysfunction, which may be more prevalent in males.'], ['The isolation of nuclei from these distinct cell populations provides an opportunity to identify cell-type-specific nuclear proteins, histone modifications, and regulation networks that are altered with normal brain aging or neurodegenerative disease.'], ['Blood platelets have been widely proposed as biomarkers in studies of mitochondrial function and aging-related and neurodegenerative diseases.'], ['Brain anatomy variability is a major problem in quantifying functional images in nuclear medicine, in particular relative to aging and neurodegenerative diseases.'], ['In this chapter we are treating yeast cells as a model for oxidative stress response and the consequences of oxidative stress which are one cause for a number of human diseases, including neurodegenerative diseases, which form the main part of this paper.', "A general overview is given how yeast can aid current research in three of the most devastating and at the same time quantitatively most important neurodegenerative diseases of old age: Alzheimer's, Huntington's, and Parkinson's disease."], ['This deterioration is the primary risk factor for major human pathologies, including cancer, diabetes, cardiovascular disorders, and neurodegenerative diseases.'], ['These observations may foster the development of novel, possibly preclinical biomarkers and immunotherapeutic strategies that target alpha-synuclein in neurodegenerative disease.'], ['Although increased physical activity may improve mobility, balance and wellbeing, adherence to exercises and activity programs over the longer term can be challenging, particularly for older people with progressive neurological conditions such as PD.'], ['We review SOD2\'s potential involvement in the progression of neurodegenerative diseases such as stroke and Alzheimer and Parkinson diseases, as well as its potential role in "normal" age-related cognitive decline.', 'We also examine in vivo models of endogenous oxidative damage based upon the loss of SOD2 and associated neurological phenotypes in relation to human neurodegenerative disorders.'], ["These clinical observations suggest that defective NER/TCR might also play a critical role in chronic neurodegenerative disorders (ND), such as Alzheimer's and Parkinson's disease.", 'Involvement of NER/TCR in these disorders is also substantiated by the evidence that aging constitutes the principal risk factor for chronic ND and that this DNA repair mechanism is very relevant for the aging process itself.', 'Our understanding of the exact role of NER/TCR in chronic ND, however, is extremely rudimentary; while there is no doubt that defective NER/TCR can lead to neuronal death, evidence for its participation in the etiopathogenesis of ND is inconclusive thus far.', 'Here we summarize the experimental observations supporting a role for NER/TCR in chronic ND and suggest questions and lines of investigation that might help in addressing this important issue.', 'We also present a preliminary yet unprecedented meta-analysis on human brain microarray data to understand the expression levels of the various NER factors in the anatomical areas relevant for chronic ND pathogenesis.'], ['In light of this, O. degus has recently been identified as a very valuable animal model for research in several medical fields, especially those concerned with neurodegenerative diseases in which risk is associated with aging.'], ['Connectivity metrics based on the k-core may help understand brain network breakdown as cognitive impairment increases, revealing how degenerative diseases affect the human connectome.'], ['RAGE activation has been implicated in ageing as well as in a number of age-related diseases, including atherosclerosis, neurodegeneration, arthritis, stoke, diabetes and cancer.'], ['CLU exerts a small heat shock protein-like stress-induced chaperone activity and has been functionally implicated in numerous physiological processes as well as in ageing and most age-related diseases including tumorigenesis, neurodegeneration, and cardiovascular and metabolic syndromes.'], ['BACKGROUND: Age-related olfactory loss (presbyosmia) substantially decreases quality of life, presages neurodegenerative disease, impairs nutrition, and predicts mortality.'], ['Transcriptome deregulation caused by miRNA dysfunction has been associated to neurodegenerative diseases.', 'Parkinson disease (PD) is the second most common neurodegenerative disease showing deregulation of the coding and small non-coding transcriptome.'], ['An X-ray of her cervical spine showed degenerative discopathies from C4 to C7.'], ['Sirtuins (SIRTs), a family of nicotinamide adenine dinucleotide (NAD)-dependent deacetylases, are emerging as key molecules that regulate aging and age-related diseases including cancers, metabolic disorders, and neurodegenerative diseases.'], ['The recent discovery of a simple method for making induced pluripotent stem cells (iPSC) from human somatic cells was a major scientific advancement that opened the way for many promising new developments in the study of developmental and degenerative diseases.', 'Clinically relevant phenotypes of neurodegenerative pathologies have also been observed using iPSC derived human neuronal cultures.'], ['Aberrant O-GlcNAcylation has been implicated in a plethora of human diseases, including diabetes, cancer, aging, cardiovascular disease, and neurodegenerative disease.'], ["The expression of disease-linked genes in specific neuronal populations of the Drosophila brain, can be used to model human neurodegenerative diseases such as Parkinson's and Alzheimer's (5).", "In Parkinson's disease (PD), the most common neurodegenerative movement disorder, the accelerated loss of DA neurons leads to a progressive and irreversible decline in locomotor function.", 'The identification of such PD-associated alleles provides the experimental basis for the use of Drosophila as a model to study neurodegeneration of DA neurons in vivo.', 'Here we describe two assays that have commonly been used to study age-dependent neurodegeneration of DA neurons in Drosophila: a climbing assay based on the startle-induced negative geotaxis response and tyrosine hydroxylase immunostaining of whole adult brain mounts to monitor the number of DA neurons at different ages.'], ['Aroma and taste greatly condition our food preference, selection and, consumption; the decreased appetite in patients with known neurodegenerative diseases may lead to dietary restrictions that could negatively impact nutritional and health status.'], ["Although the brain's ability to change constantly in response to external and internal inputs is now well recognized the mechanisms behind it in normal aging and neurodegeneration are less well understood.", 'The results of these studies in normal aging and neurodegeneration have emerged reasonably coherent in delineating the main pathology in spite of considerable technical limitations, omnipresent methodological variability, and extraordinary patient heterogeneity.', "The present review provides a TMS perspective of changes in cortical neurophysiology and neurochemistry in normal aging and neurodegeneration by integrating what is revealed in individual TMS measurements of cortical excitability and plasticity in physiological aging, Alzheimer's, Parkinson's, and Huntington's, disease.", 'The paper also reflects on current developments in utilizing TMS as a physiologic biomarker to discriminate physiologic aging from neurodegeneration and its potential as a method of therapeutic intervention.'], ['According to CTCAE (version 3.0) criteria, none of the patients developed radiation-induced neurological status deterioration or necrosis.'], ['Among primates, humans are uniquely vulnerable to many age-related neurodegenerative disorders.'], ['Its characteristics are (1) profound growth deficiency affecting all tissues, including the brain, (2) premature aging marked by cachexia, vascular disease, exocrine deficiency, and osteopenia, but not cancer, and (3) a selective degenerative disorder of central and peripheral myelin and by neuronal loss in the retina and inner ear, and in the cerebellum and basal ganglia where it is associated with calcification.'], ['beta-amyloid storage, neurofibrillary tangle formation, lipofuscin, are relatively well known, we are still looking for a suitable animal model to study the mechanisms of aging and neurodegenerative diseases.'], ['These diseases are often caused by inherited genetic mutations that result in abnormal nervous system development, neurodegeneration, or impaired neuronal function.'], ["Mutation of the human gene superoxide dismutase (hSOD1) triggers the fatal neurodegenerative motorneuron disorder, familial amyotrophic lateral sclerosis (ALS or Lou Gehrig's disease)."], ['Furthermore, lack of symptoms and disorders have a strong influence on good SRH (no leg edema - OR=4.06, CI=1.63-10.12, p<0.01; no headache - OR=2.75, CI=1.34-5.62, p<0.01; no toothache - OR=4.32, CI=1.12-16.68, p<0.05; no hypertension - OR=1.78, CI=1.02-3.14, p<0.05; no degenerative disease - OR=1.88, CI=1.08-3.27, p<0.05).'], ['The increased risk for neurodegenerative and neuropsychiatric disorders associated with extended lifespan has long suggested mechanistic links between chronological age and brain-related disorders, including depression, Recent characterizations of age-dependent gene expression changes now show that aging of the human brain engages a specific set of biological pathways along a continuous lifelong trajectory, and that the same genes that are associated with normal brain aging are also frequently and similarly implicated in depression and other brain-related disorders.'], ['Studies of the neurobiology of aging are beginning to decipher the mechanisms underlying not only the physiology of aging of the brain but also the mechanisms that make people more vulnerable to cognitive dysfunction and neurodegenerative diseases.'], ["Alzheimer's disease begins about two decades before the onset of symptoms or neuron death, and is believed to be caused by pathogenic amyloid-beta aggregates that initiate a cascade of molecular events culminating in widespread neurodegeneration.", 'However, the correspondence between the distribution of plaques and the pattern of neurodegeneration is tenuous.'], ['A chemopreventive activity test for degenerative diseases of the eye revealed that pretreatment with the carrot extract reduced cell death in a retinal ganglion cell line, RGC-5 cells exposed to 1-buthionine- (R,S)-sulfoximine and L-glutamic acid.'], ["Here, we provide an overview of age-related changes in the brain's chromatin structures, highlight potential epigenetic drug targets for cognitive decline and age-related neurodegenerative disease, and discuss opportunities and challenges when studying epigenetic biomarkers in aging research."], ["Apolipoprotein D (Apo D) is a lipid binding protein whose expression is strongly induced in the mammalian brain during aging and age-dependent neurodegenerative diseases such as Alzheimer's disease (AD), where it can play an important function as a neuroprotective and antioxidant protein."], ['Lipofuscin accumulation has been observed in a number of neurodegenerative diseases.'], ['Moreover, as XPC-deficient patients do not present neurodegeneration, premature aging, or developmental clinical symptoms, the results indicate that defects in the repair/tolerance of oxidatively generated DNA lesions are not sufficient to explain these severe clinical features of certain XP patients.'], ['Public health policy should also prioritize chronic degenerative diseases prevention and care for indigenous people.'], ['These data offer evidence for additive adverse effects of high BMI on the brain, especially in areas already vulnerable to aging processes and age-related neurodegenerative diseases.'], ["Mitochondrial dysfunction has been demonstrated in many neurodegenerative disorders, including Alzheimer's disease, Parkinson disease, amyotrophic lateral sclerosis, and some cancers."], ['In humans there are seven Sirtuins (SIRT1-7) that are implicated in various physiological processes including aging and age-related disorders such as neoplasms, cardiovascular, metabolic and neurodegenerative diseases, and inflammation.'], ['BER protects against cancer, aging, and neurodegeneration and takes place both in nuclei and mitochondria.'], ['Reproductive senescence in women is a process that begins with regular menstrual cycles and culminates in menopause followed by gradual development of diseases such as autoimmune diseases, osteoporosis, neurodegenerative diseases, and hormone-dependent cancers.'], ["beta-Amyloid (Abeta) plaque deposition and neurodegeneration within temporoparietal and hippocampal regions may indicate increased risk of Alzheimer's disease (AD).", 'This study examined relationships between AD biomarkers of Abeta and neurodegeneration as well as cognitive performance in cognitively normal older individuals.', 'In the normal older individuals, there was no association between elevated PIB uptake and either the single-modality or the multimodality neurodegenerative biomarkers.', 'The findings indicate that neurodegeneration occurs within AD regions regardless of Abeta deposition and accounts for worse cognition in cognitively normal older people.'], ['The neurobiological basis for cognitive dysfunction may be related to structural changes that reflect neurodegeneration.'], ['Many reports have linked oxidative damage to DNA and the associated avoidance and/or repair processes to carcinogenesis, ageing and neurodegeneration.', 'Cancer incidence increases with age and there is evidence that oxidative stress plays a role in human ageing and neurodegeneration.', 'The present study provides evidence that a decrease in BER of oxidatively damaged DNA may play a role in carcinogenesis, ageing and neurodegeneration.'], ['Multiple factors have been identified regulating the cell levels of RGN transcripts and protein, and an altered expression pattern of this interesting protein has been found in cases of reproductive disorders, neurodegenerative diseases and cancer.'], ["Its complex nervous system, conserved neurological function, and human disease-related loci allow Drosophila to be an ideal model organism for the study of neurodegenerative disease, for which it is used today, aiding research into diseases such as Alzheimer's and Parkinson's, which are becoming more prevalent in today's ageing population."], ['Today, the major challenges for medical science are age-related diseases, including cancer, heart disease, lung disease, renal disease, and late-onset neurodegenerative disease.', 'Of these, only the neurodegenerative diseases represent a class of disease so poorly understood that no general strategies for prevention or treatment exist.', 'The first section of this review summarizes the diversity and common features of the late-onset neurodegenerative diseases, with a particular focus on protein misfolding and aggregation-a recurring theme in the molecular pathology.', 'The second section focuses on the particular case of ALS, a late-onset neurodegenerative disease characterized by the death of central nervous system motor neurons, leading to paralysis and patient death.', 'This review discusses past studies exploring the stability, folding, and misfolding behavior of SOD1, as well as the therapeutic possibilities of using detailed knowledge of misfolding pathways to target the molecular mechanisms underlying ALS and other neurodegenerative diseases.'], ['Loss of endogenous E2 in women at menopause or after surgical oopherectomy leads to an increase risk of stroke, neurodegenerative disease, and cognitive decline.', 'Although a wide array of mechanisms has been proposed for estradiol (E2)-dependent neuroprotection in cerebral ischemia and neurodegenerative disease, most of these mechanisms involve interactions of E2 with one of its cognate receptors, estrogen receptor alpha (ERalpha), estrogen receptor beta (ERbeta), or the G protein-coupled estrogen receptor (GPER).'], ['Mitochondrial DNA has been used to investigate phylogenetic relationships and pathophysiologic roles in aging, degenerative diseases, and cancer.'], ['Because several studies suggest that oxidative stress plays a central role in neurodegeneration, we aimed to investigate the role of the antioxidant glutathione (GSH) in the activation of human A4V Sod1 during chronological aging.'], ['Oxidative stress is a widely recognized cause of cell death associated with neurodegeneration, inflammation, and aging.'], ["Parkinson's disease (PD) is a currently incurable neurodegenerative disorder that affects the aging population.", 'Current efforts for the treatment of PD are directed toward the discovery of compounds that show promise in impeding age-dependent neurodegeneration in PD patients.', 'Overexpression of alpha-Syn in animal models of PD replicates key symptoms of PD, including neurodegeneration.', 'Here, we use the nematode Caenorhabditis elegans as a model system, whereby alpha-Syn toxicity causes dopaminergic neurodegeneration, to test the capacity of valproic acid (VA) to protect neurons.'], ['As human lifespan increases so does the incidence of age-associated degenerative joint diseases, resulting in significant negative socioeconomic consequences.', 'The objectives of this review are to provide an overview of the current knowledge about the sources of endogenous and exogenous damaging agents and how they contribute to age-dependent degenerative joint disease, and highlight animal models of accelerated aging that could potentially be useful for identifying causes of and therapies for degenerative joint diseases.'], ['Base excision repair (BER) is a major DNA repair pathway employed in mammalian cells that is required to maintain genome stability, thus preventing several human diseases, such as ageing, neurodegenerative diseases and cancer.'], ["OBJECTIVE: Alzheimer's disease (AD) pathology of amyloid beta (Abeta) accumulation and neurodegeneration may be relevant to preclinical cognitive decline.", 'The objective of this study was to relate AD-sensitive biomarkers of Abeta and neurodegeneration and their interaction to longitudinal cognitive change in cognitively normal elderly.', 'CONCLUSIONS: Our findings indicate that cognitive trajectories deteriorate at a faster rate in cognitively normal individuals expressing Abeta burden and neurodegeneration within specific AD-sensitive regions.'], ['Moreover, aberrant control of the PI3-K/Akt axis is emerging to be a primary causative node in all major diseases of aging: cancer, type 2 diabetes mellitus (T2DM), heart disease and neurodegeneration.'], ['Mouse lemurs are non-human primate models of cerebral aging and neurodegeneration.'], ['The pathologies associated with aging, such as metabolic syndrome, neurodegeneration, and cancer, are either caused by or exacerbated by a lifetime of chronic stress.'], ['At least in experimental models so far, resveratrol prevents infections, inflammation, neurodegenerative diseases, and cancer.'], ['Analysis of animal models has also implicated epigenetic mechanisms in impaired cognition associated with aging, neurodegenerative disease, and intellectual disability (ID).'], ["Parkinson's disease (PD), following Alzheimer's disease, is the second-most common neurodegenerative disorder in the United States."], ['The pathophysiological mechanisms underlying normal aging and neurodegenerative disorders represent the focus of a bulk of recent research.'], ['Its course is non-linear, dynamic, adaptive to maladaptive, and compensatory to decompensatory, affecting large-scale neural networks through a plethora of mechanistic and signaling pathway alterations that converge into regional and cell type-specific neurodegeneration and, finally, into clinically overt cognitive and behavioral decline.'], ['Accumulation of cytotoxic misfolded and aggregated species may cause cell death, tissue loss, degenerative conformational diseases, and aging.'], ["All four types of responses involve the genetic machineries that underlie a number of complex human diseases such as cancer and neurodegenerative diseases, including Alzheimer's and Parkinson's."], ["Accumulation of tau is a critical event in several neurodegenerative disorders, collectively known as tauopathies, which include Alzheimer's disease and frontotemporal dementia."], ["Altered P-gp function has also been implicated in neurodegenerative diseases such as Alzheimer's and Parkinson's disease."], ['While Alzheimer disease (AD) is considered a neurodegenerative disorder, the importance of chromosome instability in non-neuronal cells is equally important, not only for shedding light on the etiology of the disease, but also for possible diagnostic purposes and monitoring the progress of the disease.'], ["Most prior studies addressing the role of miRNAs in neurodegenerative diseases (NDs) have focused on individual diseases such as Alzheimer's disease (AD), making disease-to-disease comparisons impossible.", 'While we find no apparent changes in isomiR or miRNA editing patterns in correlation with ND pathology, our results validate and extend previous miRNA profiling studies with regard to quantitative changes in NDs.'], ['An inbred prematurely aging rat strain (OXYS) is characterized by high sensitivity to oxidative stress, lipid peroxidation, protein oxidation, DNA rearrangements, and pathological conditions paralleling several human degenerative diseases including learning and memory deterioration.'], ['To date, even less is known about these processes in older adults with neurodegenerative diseases, particularly those which impact on motor functioning.'], ['Mammalian aging is associated with reduced tissue regeneration, increased degenerative disease, and cancer.'], ['Based on these findings, we suggest that post-ischemic treatment with high doses of E2 or certain non-feminizing estrogen analogs may have great therapeutic potential for treatment of brain damage and neurodegeneration associated with ischemia.'], ['An important additional limitation of the study by Guerra and colleagues and all previous post-ICU cognitive outcome studies is the inability to determine what role, if any, cognitive impairments that existed before the critical illness contribute to the diagnosis of new post-ICU dementia and whether such cognitive impairments are stable over time or are progressive like those observed in neurodegenerative diseases.'], ['BDNF is one of the key molecules modulating brain plasticity and it affects cognitive deficit associated with aging and neurodegenerative disease.', "Several studies have shown an altered BDNF production and secretion in a variety of neurodegenerative diseases like Alzheimer's and Parkinson's diseases but also in mood disorders like depression, eating disorders and schizophrenia."], ['Parkinson disease (PD) is a complex neurodegenerative disorder with both motor and nonmotor symptoms owing to a spreading process of neuronal loss in the brain.'], ['Our candidate genes act in pathways implicated in aging and longevity, including neurodegeneration, cognitive function, lipid metabolism, DNA repair, and genome maintenance.'], ["BACKGROUND: Alzheimer's Disease (AD) is a progressive neurodegenerative disease, especially affecting the hippocampus."], ['This unique potential provides significant promise for cell-based therapies to restore tissues or organs destroyed by injuries, degenerative diseases, aging, or cancer.'], ['The lysosomal degradation pathway of autophagy has a crucial role in defence against infection, neurodegenerative disorders, cancer and ageing.'], ['In laboratory animals, calorie restriction (CR) protects against aging, oxidative stress, and neurodegenerative pathologies.'], ['During the past decade, investigators have reported the relationship between disturbance of Sirt1 activation and the onset of aging- and obesity-associated diseases such as diabetes, cardiovascular disease and neurodegenerative disorders.'], ['These same systems are also affected by neurodegenerative diseases.', 'Recent work using techniques for presymptomatic detection of disease in cognitively normal older people has shown that some of the late life alterations in cognition, neural structure, and function attributed to aging probably reflect early neurodegeneration.'], ['BACKGROUND: Whereas many causes and mechanisms of neurodegenerative diseases have been identified, very few therapeutic strategies have emerged in parallel.', 'We then tested the hypothesis that increasing cellular levels of miRNA-22 would achieve neuroprotection in in vitro models of neurodegeneration.', 'As predicted, overexpression of miR-22 inhibited neurodegeneration in primary striatal and cortical cultures exposed to a mutated human huntingtin fragment (Htt171-82Q).', 'Overexpression of miR-22 also decreased neurodegeneration in primary neuronal cultures exposed to 3-nitropropionic acid (3-NP), a mitochondrial complex II/III inhibitor.'], ['Detailed clinical and neuropathological data showed the young and aged HIVE patients had higher viral load, increased neuroinflammation and elevated neurodegeneration; however, aged HIVE postmortem brain tissues showed the most severe neurodegenerative pathology.', 'These data indicate differential alterations in the autophagy pathway in young versus aged HIVE patients and that autophagy reactivation may ameliorate the neurodegenerative phenotype in these patients.'], ["Additionally, the relationship between UPS dysfunction and human neurodegenerative disorders affecting the retina, including Alzheimer's, Parkinson's, and Huntington's diseases, are dealt with, together with numerous instances of retina-specific illnesses with UPS involvement, such as retinitis pigmentosa, macular degenerations, glaucoma, diabetic retinopathy (DR), and aging-related impairments."], ['Accordingly, converging evidence indicates that mutagenic mechanisms of environmental and endogenous sources play a fundamental pathogenic role in degenerative eye diseases.'], ["In traditional practices of medicine, numerous plants have been used to treat cognitive disorders, including neurodegenerative diseases such as Alzheimer's disease (AD) and other memory-related disorders.", 'In western medicine most of the drugs used for the treatment of neurodegenerative disorders are derived from plant sources.', 'This review provides leads for identifying potential new drugs from plant sources for the treatment of neurodegenerative disorders.'], ['We have previously shown that increases in astrocytic monoamine oxidase-B (MAO-B) expression, mimicking that which occurs with aging and in neurodegenerative disease, in a doxycycline (dox)-inducible transgenic mouse model evokes neuropathological similarities to what is observed in the human parkinsonian brain.'], ["Alzheimer's disease (AD) is a progressive neurodegenerative disorder that primarily affects the elderly."], ['With increasing aging population, cognitive deteriorations due to neuro- degenerative diseases or stroke are so commonly observed that it is thought to be inevitable with aging.'], ["Studies in rats and mice have shown that high choline intake during gestation or the perinatal period improves cognitive function in adulthood, prevents memory decline of old age, and protects the brain from damage and cognitive and neurological deterioration associated with epilepsy and hereditary conditions such as Down's and Rett syndromes."], ['In particular, the grafted cells can sustain functional recovery in animal models of a range of neurodegenerative conditions including genetic and idiopathic neurodegenerative diseases of adulthood and aging, ischemic stroke, and brain and spinal cord trauma.'], ['Alzheimers disease (AD) represents the most prevalent neurodegenerative disorder that causes cognitive decline in old age.'], ['RC dysfunctions and deleterious superoxide overproduction are recurrent themes in human pathologies, ranging from neurodegenerative diseases to cancer, and may be instrumental in ageing.'], ['The biomarkers evaluated were brain Abeta load via Pittsburgh compound B (PiB)-positron emission tomography (PET), neuronal dysfunction via (18) F-fluorodeoxyglucose (FDG)-PET, and neurodegeneration via structural magnetic resonance imaging (MRI).'], ['Osteoarthritis (OA) is a degenerative joint disease particularly affecting the elderly population.'], ['Ischemic insults and neurodegenerative diseases are by far the leading cause of mortality and disability.', "It is now clearly established that inflammatory processes play a fundamental role in the pathophysiology of both hypoperfusion/ischemia damage (be it generalized to the whole body, as in the case of shock, or limited to individual organs) and neurodegenerative diseases (Alzheimer's disease, Parkinson's disease, multiple sclerosis, amyotrophic lateral sclerosis).", 'The above arguments support the view that pharmacokinetically suitable agonists at MC3/MC4 melanocortin receptors may represent a completely innovative class of drugs for an effective treatment of both ischemic and neurodegenerative diseases.'], ["Parkinson's disease (PD) is a neurodegenerative disorder characterized by a multifactorial nature due to the reduction in dopamine level in the brain."], ['These findings may have relevant implications in the light of the knowledge that iron accumulates in brain regions of patients suffering from neurodegenerative diseases.'], ["The investigation of cerebral resting-state networks (RSNs) by functional magnetic resonance imaging (fMRI) is a promising tool for the early diagnosis and follow-up of neuropsychiatric and neurodegenerative disorders like Alzheimer's disease (AD)."], ["Alzheimer's disease (AD) is a multifaceted neurodegenerative disorder which is characterized by the progressive deterioration of cognition and the emergence of behavioral and psychological symptoms in aging patients."], ['Bacopa monnieri (brahmi), an Ayurvedic herb, and donepezil, a reversible acetylcholinesterase inhibitor, have been used to reverse cognitive dysfunctions in several neurodegenerative diseases.', 'Taken together, these results suggest that both brahmi and donepezil exert distinct age-related effects on the cell-mediated immune responses through selective modulation of antioxidant enzyme activities and intracellular targets that may influence the therapeutic efficacy of these drugs in neurodegenerative diseases.'], ['Importantly, age is the greatest risk factor for a number of neurodegenerative diseases.'], ['Severe mitochondria deficiency leads to a number of devastating degenerative disorders, yet, mild mitochondrial dysfunction in different species, including the nematode Caenorhabditis elegans, can have pro-longevity effects.'], ["It is not known if this deficit is specific to AD, or also present in other neurodegenerative disorders that can occur in later life, such as Parkinson's disease (PD)."], ['Our previous studies showed that loss of the enzymatic activity of HTRA2 due to a Ser276Cys missense mutation in its catalytic domain is associated with early onset neurodegeneration, multiple tissue atrophy and premature lethality in homozygous htra2 (mnd2) mice, suggesting that HTRA2 is neuroprotective.', 'Notably, this HTRA2 transgene rescues htra2 (mnd2) mice from early onset neurodegeneration, and other phenotypic abnormalities and prevents their early death, indicating that HTRA2 activity in neuronal mitochondria is important for neuronal cell survival.', 'Our findings suggest that HTRA2-regulated protein quality control in the intermembrane space of mitochondria is important for the maintenance of mitochondrial homeostasis, and loss of HTRA2 activity can lead to both neurodegeneration and aging.'], ['HIV+ people who carried the apolipoprotein E4 allele (ApoE4) genotype-which puts them at even greater risk for neurodegeneration-showed additional network structure deficits in temporal and parietal connections.'], ['Studies have demonstrated brain iron deposition in neurodegenerative disease and in normal aging.'], ['Oxidative stress-induced damage to neurons may contribute to cognitive deficits during aging and in neurodegenerative disorders.'], ["Does accelerated cortical atrophy in aging, especially in areas vulnerable to early Alzheimer's disease (AD), unequivocally signify neurodegenerative disease or can it be part of normal aging?", 'While steady decline in cortical thickness is the norm in aging, acceleration in AD-prone regions does not uniquely signify neurodegenerative illness but can be part of healthy aging.'], ['Defects in mitochondrial electron transport chain (ETC) function have been implicated in a number of neurodegenerative disorders, cancer, and aging.'], ['However, alterations in apoptosis have been associated with neurodegeneration in the aging DS brain, with impairments in general growth and with immunological, cardiovascular and oncological alterations.'], ["Alzheimer's disease (AD) is a chronic neurodegenerative disease with well-defined pathophysiological mechanisms, mostly affecting medial temporal lobe and associative neocortical structures."], ['Different factors interact to develop neurodegeneration in patients with dementia and other neurodegenerative disorders.', 'Oxidative stress and the epsilon4 allele of apolipoprotein E (ApoE) are associated with significant alteration in lipid metabolism, in turn connected to a variety of neurodegenerative diseases and aging.', 'To address this issue, we evaluated the effects of antioxidant status and APOE genotype on neurodegeneration in patients with dementia of the Alzheimer type (AD), with vascular dementia (VaD), and in elderly healthy controls.', 'These outcomes further sustain the interaction of oxidative stress and APOE genotype to neurodegeneration.'], ['In the aging retina, free radicals and oxidized lipoproteins are considered to be major causes of tissue stress resulting in local triggers for parainflammation, a chronic status which contributes to initiation and/or progression of many human neurodegenerative diseases such as AMD.'], ['The consumption of vegetables, fruits and flavonoid-rich beverages has been reported to prevent against neurodegenerative diseases, cancer, and ageing.', 'This paper reviews the recent data on (1) the role oxidative stress in the pathology of civilization diseases; (2) the protection against oxidative damage due to the toxicity of ROS/RNS; (3) the cellular and molecular interactions of the (poly)phenolic compounds relevant to the prevention of neurodegenerative diseases and cancer, and (4) the methods for assessing antioxidant capacity.'], ['BACKGROUND: Glaucoma comprises age-related neurodegenerative diseases of retinal ganglion cells, the worldwide prevalence of which is increasing.'], ['Among the human diseases associated with epigenetic factors, aging-related and neurodegenerative diseases are probably the object of most intense research.', 'This review will present the main evidences linking several human diseases to DNA methylation, with particular focus on neurodegenerative diseases, together with a short description of the state-of-the-art of methylation assays.'], ['Chronic kidney disease impairs glomerular filtration rate, and this deterioration is indicated by elevated blood levels of kidney biomarkers such as creatinine and cystatin C. Here we hypothesized that impaired renal function would be associated with brain deficits in regions vulnerable to neurodegeneration.'], ['RESULTS: Overall, the prevalence estimates of multimorbidity were similar for the three different definitions (15% [95%CI 11-18%], 13% [95%CI 10-16%], and 14% [95%CI 11-17%], respectively), and were higher than the prevalence estimates of any specific chronic health condition (hypertension, uncomplicated 9% [95%CI 7-11%], back syndrome with and without radiating pain 6% [95%CI 5-7%], non-insulin dependent diabetes mellitus 3% [95%CI 3-4%]), and degenerative joint disease 3% [95%CI 2%-4%]).'], ['BACKGROUND: As the population ages, changes occur in the epidemiological profile towards the current predominance of chronic degenerative diseases which, when untreated, lead to loss of functional capacity and require long-term assistance.'], ['BACKGROUND AND AIM OF THE STUDY: With the changing age structure of the population, cardiothoracic surgeons must deal with an increasing number of patients suffering from degenerative valve disease.', 'Of these patients, 70% had degenerative disease, 19% endocarditis, and 11% a rheumatic cause, while 24% underwent cardiac redo-surgery.'], ['In this review, we revisit the research progress of miRNAs in C. elegans related with development, aging, cancer, and neurodegenerative diseases and compared the function of miRNAs between C. elegans and human.'], ['It is now emerging that somatic mutations in mitochondrial DNA (mtDNA) are also linked to other complex traits, including neurodegenerative diseases, ageing and cancer.'], ['Amyloid burden and white matter hyperintensities (WMH) are two common markers of neurodegeneration present in advanced aging.'], ['Dehydroepiandrosterone (DHEA), a steroid pro-hormone, decreases with age but an exaggerated decline has been associated with chronic degenerative diseases.'], ['Neurodegenerative disorders constitute a growing concern worldwide.'], ['METHODS: Participants were 104 seniors, 62 women and 42 men, ranging in age from 60 to 88 years (mean 70.6), who reported good general health, no history of degenerative diseases, neurological or any other diseases that could influence swallowing participated.'], ['More recently, we have built a database of proteins modified by carbonylation, glycation and lipid peroxidation products during aging and age-related diseases, such as neurodegenerative diseases.'], ['Protein damage mediated by oxidation, protein adducts formation with advanced glycated end products and with products of lipid peroxidation, has been implicated during aging and age-related diseases, such as neurodegenerative diseases.'], ['MAGL inhibition also prevented neuroinflammation, decreased neurodegeneration, maintained integrity of hippocampal synaptic structure and function, and improved long-term synaptic plasticity, spatial learning, and memory in AD animals.'], ['Although the prevalence of neurodegenerative diseases is increasing as a consequence of the growing aging population, the exact pathophysiological mechanisms leading to these diseases remains obscure.', 'The ability to make an early diagnosis of MS with the support of conventional MRI techniques, provides the opportunity to study neurodegeneration and the underlying pathophysiological processes in earlier stages than in classical neurodegenerative diseases.', 'This review summarizes mechanisms of neurodegeneration common to MS and to Alzheimer disease, Parkinson disease, and amiotrophic lateral sclerosis, and provides a brief overview of the neuroimaging studies employing MRI and PET techniques to investigate and monitor neurodegeneration in both MS and classical neurodegenerative diseases.'], ["Androgens' metabolism and activity are gaining a more and more important role in human physiology particularly referring to aging and to neurodegenerative diseases."], ['This DNA damage increase the frequency of errors in DNA replication, thus causing point mutations or chromosomal rearrangements and has been implicated in aging, cancer, and neurodegenerative diseases.'], ['These enzymes also have primarily protective functions in the development of many age-related diseases, including cancer, neurodegeneration, and cardiovascular disease.'], ['Ostensibly de novo somatic mtDNA mutations, seen in mtDNA maintenance disorders and neurodegenerative disease and aging, will partly be due to the clonal expansion of low-level inherited variants.'], ['The alterations occur very early in the course of neurodegeneration, enabling medical follow-up of persons with increased risk of developing dementia.'], ['Such variability is elevated in neurodegenerative diseases or following traumatic brain injury.'], ['Next to pathological protein folding and impaired protein degradation pathways, alterations of mitochondrial function and morphology were pointed out as further hallmark of neurodegeneration in PD (3-11).', 'Hence, the assays presented here can be utilized as valuable tools to identify pathological features of neurodegeneration and help to define new therapeutic strategies in PD.'], ['In line with this notion, primary mitochondrial defects or alterations in the signaling pathways that converge on or emanate from mitochondria underpin a large number of human diseases, including premature aging, neurodegenerative disorders, cardiovascular disorders, and cancer.'], ['Adiponectin, an adipocytokine released by the adipose tissue and has important roles in the metabolic regulation and inflammatory control, may play an important roles in the physiopathology of psychiatric and neurodegenerative disorders.'], ["Alzheimer's disease (AD) is a complex neurodegenerative disorder and the most common dementia among the elderly."], ['The etiology of oropharyngeal dysphagia can be broad, and includes aging with atrophy, debilitation, stroke, neurodegenerative and muscular diseases, tumor and postsurgical deformity, as well as effects due to medications and drying of the mucosal membranes.'], ["Neurodegenerative disorders are often defined pathologically by the presence of protein aggregates, such as amyloid plaques composed of beta-amyloid (Abeta) peptide in Alzheimer's disease.", 'Our results further contribute to identifying common pathological pathways involved in both aging and progressive neurodegenerative disorders enhancing the understanding of disease pathogenesis.'], ['Recent research has implicated inflammatory processes in the pathophysiology of a wide range of chronic degenerative diseases, although inflammation has long been recognized as a critical line of defense against infectious disease.'], ['Over time the ability to do physical and intellectual work deteriorates, and susceptibility to infectious, metabolic, and neurodegenerative diseases increases, which leads to general fitness decline and ultimately to death.'], ['Growing studies have shown that defects or induced autophagy contributes to many diseases including aging, neurodegeneration, pathogen infection, and cancer.'], ['Here, we further characterize this transgenic strain in order to reveal a possible link between hypeprlipidemia and neurodegeneration.', 'CONCLUSIONS: The results presented here indicate that elevated ApoB-100 level and the consequent chronic hypertriglyceridemia may lead to impaired neuronal function and neurodegeneration, possibly via hyperphosphorylation of tau protein.', 'On account of their specific phenotype, ApoB-100 transgenic mice may be considered a versatile model of hyperlipidemia-induced age-related neurodegeneration.'], ["Then, pertinent to the recent National Institute on Aging and the Alzheimer's Association's consensus statement on the diagnosis of prodromal AD, we focus on assessing the cerebral metabolic changes associated with neurodegenerative diseases that are identified with fluorodeoxyglucose PET, as well as consider the most appropriate roles for amyloid imaging based on recent studies examining the use of PET with tracers having higher retention in brain tissue-harboring plaques composed of insoluble beta-amyloid."], ['Changes of the proteasome make-up during aging may be a priming factor for neurodegenerative diseases, described last.'], ['ROS cause oxidative damage to proteins, lipids, and DNA and are one of the most prominent factors related to neurodegeneration.', 'Several herbal products are beneficial for maintaining nerve cell function and for treating various neurodegenerative disorders by reducing oxidative stress.'], ['On the other hand, the preservation of the adult stem cell pool, and the ability of cells to deal with DNA damage, is essential for normal development, reducing processes of neurodegeneration and premature aging, as one can observe on clinical phenotypes of many human genetic diseases with defects in DNA repair processes.'], ['Cognitive aging is accompanied by a range of structural and functional differences in the brain, even in the absence of neurodegenerative disease.'], ['Mitoplasticity could play a protective role against aging, diabetes, cancer, or neurodegenerative diseases.'], ['Age is the leading risk factor for many of the most prevalent and devastating diseases including neurodegenerative diseases.', 'Based on the premise that astrocytes are key modulators in the progression of oxidative stress associated neurodegenerative diseases, 13 herbal extracts purported to possess anti-ageing properties were tested for their ability to protect U373 human astrocytes from hydrogen peroxide induced cell death.'], ["Alzheimer's disease (AD) is one of the most important neurodegenerative disorders, bringing about huge medical and social burden in the elderly worldwide."], ['From this research effort the picture has emerged of an enzyme at the hub of a complex array of molecular interactions whereby nutrient-triggered signals are translated into several levels of adaptive cell responses, the failure of which underlies diseases as diverse as diabetes, neurodegeneration and cancer.'], ['mnd2 mice die prematurely as a result of neurodegeneration 30-40 days after birth due to loss of the enzymatic activity of the mitochondrial quality control protease HtrA2/Omi.', 'Here, we show that transgenic expression of human HtrA2/Omi in the central nervous system of mnd2 mice rescues them from neurodegeneration and prevents their premature death.'], ['Age is the main risk factor for the prevalent diseases of developed countries: cancer, cardiovascular disease and neurodegeneration.'], ['Reactive Oxygen Species are involved in the pathological development of many important human diseases such as neurodegenerative diseases, cardiovascular processes, diabetes and many others.'], ['In recent years, there has been a growing interest, supported by a large number of experimental and epidemiological studies, in the beneficial effects of some natural compounds in preventing various age-related pathologic conditions, including brain aging and neurodegeneration.'], ['Deregulation of this enzyme is causatively involved in the molecular development of monogenic human diseases, cancer, obesity, type 2 diabetes or neurodegeneration.'], ['The neuronal ceroid-lipofuscinoses (Batten disease) collectively constitute one of the most common groups of inherited childhood onset neurodegenerative disorders, and have also been identified in many domestic and laboratory animals.', 'Elucidation of their functions and interactions in health and disease is a prerequisite for the identification of possible therapeutic targets, but may also further our understanding of the basic mechanisms of neurodegeneration and ageing.'], ['AD is a complex neurodegenerative disorder.'], ["Neurodegenerative diseases are capturing the world's attention as being the next set of diseases we must tackle collectively.", 'Overall, this review will give a general overview of protein and metal chelator coordination environments in neurodegenerative diseases.'], ['Cognitive disorders can be associated with brain trauma, neurodegenerative disease or as a part of physiological aging.'], ["The discovery of alpha-synuclein has had profound implications concerning our understanding of Parkinson's disease (PD) and other neurodegenerative disorders characterized by alpha-synuclein accumulation."], ["These agents are considered to be involved in aging and numerous neurodegenerative diseases, such as Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD) and amyotrophic lateral sclerosis (ALS).", 'In this review we discuss the mechanistic and therapeutic considerations of KP in aging and the main neurodegenerative diseases and review the updated knowledge in this therapeutic field.'], ['In human, CR could delay many diseases associated with aging including cancer, diabetes, atherosclerosis, cardiovascular disease, and neurodegenerative diseases.'], ['The majority of neurodegenerative diseases have an important age component, and thus, understanding the molecular changes that occur during normal aging of the brain is of utmost relevance.'], ['This begets the question on the function of secretagogin in blood cells and if it is correlated to neurodegeneration associated with ageing.'], ['As we demystify its deux de machina, accumulating evidence reveal that mortalin may be "druggable" bidirectionally to either treat cancer or neuro-degenerative disorders.'], ['Mitochondrial dysfunction is linked to apoptosis, aging, cancer, and a number of neurodegenerative and muscular disorders.'], ['Age-related macular degeneration (AMD) is a neurodegenerative disease that causes irreversible central vision loss in the elderly.'], ["The neuronal histaminergic system is involved in many physiological functions and is severely affected in age-related neurodegenerative diseases such as Parkinson's disease (PD) and Alzheimer's disease (AD).", 'The production of neuronal histamine shows diurnal fluctuations in control subjects who had no neuropsychiatric disorders, while this fluctuation was strongly altered in patients with neurodegenerative diseases, including PD and AD.', 'In addition, different alterations shown as expression levels of histidine decarboxylase (the key enzyme for histamine production), histamine-methyltransferase (the histamine deactivating enzyme), and histamine receptors (H(1-4)R) were found in various neurodegenerative disorders.'], ['The increase is consistent with a secondary compensation against neurodegeneration at target areas, and may provide brain reserve against functional impairments at incipient stages of dementia.'], ['A major aim of this study was to distinguish between the effects of healthy aging and neurodegenerative disease on the voluntary control of saccadic eye movements.', 'overlap-gap) saccade reaction time was elevated in the older groups compared to young group, which yielded a strong effect of aging and no specific effect of neurodegenerative disease.', 'Healthy aging, rather than neurodegenerative disease, accounted for the increase in the saccade reaction times to the target that are presented simultaneously with a fixation stimulus.'], ['Age-related neurodegenerative diseases are associated with alterations in gene expression in affected neurons.', "One of the mechanisms that could account for this is altered subcellular localization of transcription factors, which has been observed in human post-mortem brains of each of the major neurodegenerative diseases, including Parkinson's disease (PD)."], ["A growing body of epidemiologic and experimental data point to chronic bacterial and viral infections as possible risk factors for neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease and amyotrophic lateral sclerosis.", 'Indeed, viral and microbial agents have been reported to produce molecular hallmarks of neurodegeneration, such as the production and deposit of misfolded protein aggregates, oxidative stress, deficient autophagic processes, synaptopathies and neuronal death.', 'This review will focus on the contribution given to neurodegeneration by herpes simplex type-1, human immunodeficiency and influenza viruses, and by Chlamydia pneumoniae.'], ['Neurodegeneration and depression are two common co-morbid conditions, particularly within the aging population.', 'The key to neuroinflammation effects on neurodegeneration and depression appears to lie within the dysregulation of the control and release of pro- and anti-inflammatory cytokines.', 'Our main focus will be on what research tells us about the connections between neuroinflammation, neurodegeneration, and depression, and the hope that neuroprotectants research gives people suffering from neurodegeneration and depression stemming from neuroinflammation.'], ['Evolutionary medicine acknowledges that many chronic degenerative diseases result from conflicts between our rapidly changing environment, our dietary habits included, and our genome, which has remained virtually unchanged since the Palaeolithic era.'], ['In recent years the worldwide scenario of health care has been progressively changing in the light of the ageing of the population and the increase in disability related to neurodegenerative disorders in older people.'], ['These SNPs are all contained in genes from the same superfamily, histone deacetylases, which have biological functions that are relevant to MS, neurodegeneration, and aging.'], ['It is now clear that the same systemic inflammatory signals can have severe deleterious effects on brain function when occuring in old age or in the presence of neurodegenerative disease.'], ['BACKGROUND: Minimally invasive transforaminal lumbar interbody fusion (MIS-TLIF) has been successfully used to treat degenerative diseases of the lumbar spine.'], ["Alzheimer's disease (AD) is a human neurodegenerative disease, and its global prevalence is predicted to increase dramatically in the following decades."], ['BACKGROUND/OBJECTIVE: Corticobasal syndrome (CBS) is a rare neurodegenerative disorder characterized by a progressive and asymmetric manifestation of cortical and basal-ganglia symptoms of different origin.'], ['Induced pluripotent stem cell (iPSC) technology can be used to model human disorders, create cell-based models of human diseases, including neurodegenerative diseases, and in establishing therapeutic strategies.', "The expression of molecules that play critical roles in late-onset neurodegenerative diseases by neurons differentiated from the centenarian-iPSCs was compared to that of neurons differentiated from iPSCs derived from familial Alzheimer's disease and familial Parkinson's disease (PARK4: triplication of the alpha synuclein gene) patients.", 'The results indicated that our series of iPSCs would be useful in neurodegeneration research.'], ["This review discusses and integrates up to date evidence from clinical and animal studies investigating the cognitive-enhancing effects of n-3 PUFA during development, child- and adult-hood, as well as old-age with associated neurodegenerative diseases, such as Alzheimer's disease."], ['From a research perspective, imaging Abeta allows us to study relationships between amyloid pathology and changes in cognition, brain structure, and function across the continuum from normal aging to mild cognitive impairment (MCI) to AD; and to monitor the effectiveness of anti-Abeta drugs and relate them to neurodegeneration and clinical symptoms.'], ["Alzheimer's Disease (AD) is a neurodegenerative disorder and the most common cause of dementia among the elderly."], ['Recent observations have indicated an emerging role for TGF-beta in the regulation of mitochondrial bioenergetics and oxidative stress responses characteristic of chronic degenerative diseases and aging.'], ['These data begin to identify biochemical biomarkers of depressive symptoms in older adults that may be useful in investigations of pathophysiological mechanisms of depression in aging and neurodegenerative dementias and as targets of novel treatment approaches.'], ['Cognitive dysfunction following major surgery on the elderly is a significant problem which adds to other cognitive impairments caused by neurodegeneration, cerebrovascular impairments and other causes.'], ['Lipid oxidation is one of the main chemical degradations occurring in biological systems and leads to the formation of compounds that are related to aging and various chronic and degenerative diseases.'], ["ARBs should be tested for the prevention and therapy of neurodegenerative disorders, in particular Alzheimer's disease, affective disorders, such as co-morbid cardiovascular disease and depression, and traumatic brain injury."], ["Neurodegenerative diseases such as Alzheimer's disease (AD) can be understood in the context of the aging of neuroimmune communication."], ['Organophosphorus-induced delayed neuropathy (OPIDN) is a neurodegenerative disorder characterised by ataxia progressing to paralysis with concomitant central and peripheral distal axonopathy.'], ['Abnormal protein aggregates have been suggested as a common pathogenesis of many neurodegenerative diseases.', 'Recent studies have demonstrated that autophagy plays a crucial role in the pathogenesis of neurodegenerative diseases characterized by abnormal protein accumulation, suggesting that regulation of autophagy may be a valuable therapeutic strategy for the treatment of various neurodegenerative diseases.', 'Taken together, these results suggest that regulation of SIRT2 could be a good therapeutic target for a range of neurodegenerative diseases by regulating autophagic flux.'], ['BACKGROUND: Beta-galactosidase is the most widely used biomarker for highlighting the processes of cellular aging, including neurodegeneration.'], ['Taken together, analysis of the biochemistry of aged neurons and the interplay with pathways of neurodegeneration may lead to a better understanding of AD and how to treat and prevent this condition.'], ["These results support the hypothesis that haplotype-specific variation in the MAPT 3' UTR underlies an Abeta-independent mechanism for neurodegeneration in TPD."], ['Interestingly, the latest advances in AMD research also highlight common molecular disease pathways with other neurodegenerative disorders.'], ['These researches provide interesting insight into the relation of neurodegenerative diseases, mitochondrial disorders, and autophagy and are useful for the pathophysiological understanding of both Wolfram syndrome and mitochondrial-mediated premature aging.'], ["The aim of this study was to assess the correlation between serum 25-OHD concentrations and regional cerebral blood flow in neurodegenerative diseases such as Alzheimer's disease (AD) and dementia of Lewy bodies (DLB)."], ['In this review, we propose that navigation deficits may help distinguish patients at higher risk of developing AD dementia from individuals with normal cognitive aging and those with other neurodegenerative diseases.'], ['This study aimed to determine the extent and basis of respiratory deficiency in paraspinal muscles from cases undergoing surgery for degenerative spinal disease and post mortem cases without a history of spinal disease, where age-related histopathological changes were previously reported.'], ['Pre-clinically, both cell-culture and animal studies suggest that anesthetics may cause neuroapoptosis, caspase activation, neurodegeneration, beta-amyloid protein (Abeta) accumulation and oligomerization, and ultimately, deficits in neurocognition.'], ['Dementia is the most common neurodegenerative disease in the elderly.'], ['Finally, the linkage of BER/SSBR deficiency to cancer, aging, and human neurodegenerative diseases, and therapeutic targeting of BER/SSBR are discussed.'], ["BACKGROUND: Alzheimer's disease (AD) is the most frequently diagnosed neurodegenerative disorder affecting humans, with advanced age being the most prominent risk factor for developing AD."], ["CONCLUSION: The potent neuroprotective capacity of EUE, shown in these experiments, may potentially be applied in the prevention or treatment of neurodegenerative diseases such as Alzheimer's disease (AD)."], ['This GSH-CSI method permits us to address regional differences of GSH in the human brain under conditions where oxidative stress has been implicated, including multiple sclerosis, aging and neurodegenerative diseases.'], ['SIRT1 inhibition has been proposed in the treatment of cancer, immunodeficiency virus infections, Fragile X mental retardation syndrome and for preventing or treating parasitic diseases, whereas SIRT2 inhibitors might be useful for the treatment of cancer and neurodegenerative diseases.'], ['Aging and neurodegeneration are often accompanied by a functionally impaired ubiquitin-proteasome system (UPS).'], ['Through a combination of retrospective human studies, small prospective biomarker studies, and experiments in animals, it is now clear that durable consequences of both anesthesia and surgery occur, and that these intersect with the normal processes of aging, and the abnormal processes of chronic neurodegeneration.'], ["Mitochondrial dysfunction represents a common early pathological event in brain aging and in neurodegenerative diseases, e.g., in Alzheimer's (AD), Parkinson's (PD), and Huntington's disease (HD), as well as in ischemic stroke.", 'In summary, the majority of preclinical data indicate beneficial effects of n-3 PUFA in neurodegenerative diseases, whereas most controlled clinical trials did not meet the expectations.'], ['Such may be crucially important to develop means to intervene with their function for therapeutic purposes, which would require functional down-regulation in cancer but up-regulation in, for instance, cardiac or degenerative neuro/neuromuscular diseases.'], ["Oxidative stress is believed to play a central role in the pathogenesis of Alzheimer's disease (AD), a neurodegenerative disease."], ['The global trend of the phenomenon of population ageing has dramatic consequences on public health and the incidence of neurodegenerative diseases.', "Physiological changes that occur during normal ageing of the brain may exacerbate and initiate pathological processes that may lead to neurodegenerative disorders, especially Alzheimer's disease (AD)."], ['Sporadic forms of VaD are caused by degenerative vessel disorders such as atherosclerosis, small vessel disease (SVD) including small vessel arteriosclerosis, arteriolosclerosis, and lipohyalinosis, and cerebral amyloid angiopathy (CAA).', 'Insufficient blood blow and alterations of the perivascular drainage mechanisms of the brain may also lead to a reduced protein clearance from extracellular space and subsequent increase of proteins in the brain parenchyma, such as the amyloid beta-protein, and foster, thereby, the development of AD-related neurodegeneration.'], ["Aging is the major risk factor associated with neurodegenerative diseases, including Alzheimer's disease (AD)."], ['Directed differentiation of hESCs into neuronal populations has galvanized much interest into their potential application in modelling neurodegenerative disease.', 'However, neurodegenerative diseases are age-related, and therefore establishing the maturational comparability of hESC-derived neural derivatives is critical to generating accurate in vitro model systems.', 'In summary, this study highlights the value of genomic indices in refining and validating optimal cell populations appropriate for modelling ageing and neurodegeneration.'], ['An age-associated increase in oxidative damage to nucleic acids, predominantly to RNA, has been recently demonstrated in neurons of human and rodent brains, which may play a fundamental role in the development of age-associated neurodegeneration.', 'Indeed, more prominent levels of neuronal RNA oxidation compared to normal aging have been described in neurodegenerative disorders including Alzheimer disease, Parkinson disease, dementia with Lewy bodies, and amyotrophic lateral sclerosis.', 'Moreover, oxidative damage to RNA has been found also in cellular and animal model of neurodegeneration.', 'While less lethal than mutations in the genome and not inheritable, such sublethal damage to cells might be associated with underlying mechanisms of degeneration, especially age-associated neurodegeneration.', 'Of particular interest, the accumulating evidence obtained from studies on either human samples or experimental models coincidentally suggests that RNA oxidation is a feature in neurons of aging brain and more prominently observed in vulnerable neurons at early-stage of age-associated neurodegenerative disorders, indicating that RNA oxidation actively contributes to the background, the onset, and the development of the disorders.', 'Further investigations aimed at understanding of the processing mechanisms related to oxidative RNA damage and its consequences may provide significant insights into the pathogenesis of neurodegenerative disorders and lead to better therapeutic strategies.'], ['We propose GHK tripeptide as a possible therapeutic agent against age-associated neurodegeneration and cognitive decline.'], ['The most common etiologies for valvular dysfunction in 491 valvular heart surgery patients were RHD (60.3%), degenerative valve disease (15.3%), and endocarditis (4.5%).', 'Strategies to reduce the burden of valvular heart disease will need to address the disparate factors that contribute to RHD as well as degenerative valve disease.'], ['Mitochondrial DNA (mtDNA) deletions are a primary cause of mitochondrial disease and are believed to contribute to the aging process and to various neurodegenerative diseases.'], ['Furthermore, increased TH homo-specific activity leading to an increase in DA may cause toxic reactive oxygen species in the neurons to promote neurodegeneration.'], ['Indeed disrupted neuronal insulin action may underlie the link between diabetes and neurodegenerative disorders.'], ['It has been reported that mitochondrial metabolic and biophysical parameters are associated with degenerative diseases and the aging process.'], ['This review dissects the relationships between activity and assembly defects of the mitochondrial respiratory chain, oxidative damage, and alterations in mitochondrial dynamics, with special focus on their implications for neurodegeneration.'], ['Estrogens have been shown to be protective agents against neurodegeneration and associated cognitive decline in aging females.', 'A unifying model is proposed by which the presence or absence of estrogens during a critical period following the cessation of ovarian function permanently alters the system resulting in decreased or increased risk, respectively, of neurodegeneration and cognitive decline.'], ['The prevalence of neurodegenerative diseases (ND) increases with aging and much of the research involving ROS and OS has emerged from works in this field.', 'This text reviews some recent published articles about the role of OS in ND.', "The search engine looked for the terms 'oxidative stress AND neurodegenerative diseases AND nutrition' in 10 different scientific collections.", 'Biochemical markers for ND lack sensitivity or specificity for diagnosis or for tracking response to therapy today.', 'OS has an intimate connection with ND, albeit low levels of ROS seem to protect the brain.', 'Deleterious changes in mitochondria, OS, calcium, glucocorticoids, inflammation, trace metals, insulin, cell cycle, protein aggregation, and hundreds to thousands of genes occur in ND.', 'The interaction of genes with their environment, may explain ND.', 'Although OS has received much attention over the years, which increased the number of scientific works on antioxidant interventions, no one knows how to stop or delay ND at present.'], ['Current evidence strongly supports a contribution of polyphenols to the prevention of several chronic degenerative diseases such as cancer, atherosclerosis and cardiovascular diseases, central nervous system disorders, as well as aging.', 'The malfunction of the death machinery may play a primary role in various pathologic processes, leading to proliferative or degenerative diseases.'], ['Elevated blood levels of extracellular nucleic acids have been reported in various disease conditions; such as ageing and age-related degenerative disorders, cancer; acute and chronic inflammatory conditions, severe trauma and autoimmune disorders.'], ['Furthermore, the increased susceptibility and limited recovery ability of hApoE4 mice to sleep apnea suggests that early recognition and treatment of the latter in AD patients may restrict the progression and clinical manifestations of this frequent neurodegenerative disorder.'], ['Oxidative stress-induced damage to neurons may contribute to cognitive deficits during aging and in neurodegenerative disorders.'], ['Especially in the last 25 years, AGEs have been implicated in complications related to aging, neurodegenerative diseases, diabetes, and chronic kidney disease.'], ['BACKGROUND: The Mental Health Research Network and Dementia and Neurodegenerative Diseases Research Network were established in the UK to increase research capacity and activity; the former in mental health generally, and the latter specifically in neurodegenerative disorders including dementia.'], ['As blood vessels get older, they often become abnormal in structure and function, thereby contributing to numerous age-associated diseases including ischemic heart and brain disease, neurodegeneration, or cancer.'], ['Oxidative stress contributes to many disease etiologies including ageing, neurodegeneration, and cancer, partly through DNA damage induction (genotoxicity).'], ['Short-term and working memory (WM) capacities are subject to change with ageing, both in normal older adults and in patients with degenerative or non-degenerative neurological disease.'], ['Multimodal studies using amyloid-tracing imaging methods and neurodegeneration biomarkers strongly suggest that neural network discoordination is specifically related to Abeta-mediated functional and potentially reversible disruption of synaptic plasticity rather than a direct consequence to neurodegenerative pathological processes.'], ['Cognitive efficiency decreases with age, and advancing age is the leading risk factor for most neurodegenerative disorders that result in dementia.', 'In the coming years, with increasing numbers of HIV+ patients entering their 60s and 70s, background risk for neurodegenerative disorders will be sufficiently high as to inform this issue on clinical grounds.'], ['Fragile X-associated tremor ataxia syndrome (FXTAS) is a late onset neurodegenerative disease that affects carriers of the fragile X premutation.'], ['IGF-I is a critical promoter of brain development and neuronal survival and plays a role in neuronal rescue during degenerative diseases.'], ['The pathway regulates many major cellular processes and is implicated in an increasing number of pathological conditions, including cancer, obesity, type 2 diabetes, and neurodegeneration.'], ["Despite great advances in identifying essential components and characterizing molecular mechanisms associated with the organelle's biogenesis and function, there is a large gap in our understanding of how peroxisomes are incorporated into metabolic pathways and subcellular communication networks, how they contribute to cellular aging, and where their influence is manifested on the initiation and progression of degenerative disease."], ['The one exception appears to be pain associated with degenerative joint disease (e.g., osteoarthritis) which shows an exponential increase until at least 90 years of age.'], ['CONCLUSIONS: These results support the investigation of the role of the advanced glycation endproduct precursor methylglyoxal in cognitive decline and neurodegeneration in older people.'], ["Reduction in CB expression has been associated with aging and with neurodegenerative disorders, including Alzheimer's disease."], ["Alzheimer's disease (AD), Parkinson's disease (PD), and amyotrophic lateral sclerosis (ALS) are the most common human adult-onset neurodegenerative diseases.", 'They are characterized by prominent age-related neurodegeneration in selectively vulnerable neural systems.', 'Genetic, biochemical, and morphological analyses of human AD, PD, and ALS, as well as their cell and animal models, reveal that mitochondria could have roles in this neurodegeneration.', 'Transgenic mouse models of human neurodegenerative disease are beginning to reveal possible principles governing the biology of selective neuronal vulnerability that implicate mitochondria and the mitochondrial permeability transition pore.', 'This chapter reviews several aspects of mitochondrial biology and how mitochondrial pathobiology might contribute to the mechanisms of neurodegeneration in AD, PD, and ALS.'], ["Deposition of aggregated amyloid beta (Abeta) is a major hallmark of Alzheimer's disease (AD)-a common age-related neurodegenerative disorder.", 'The results presented in this study support a model where Abeta pathology and aging converge, leading to accumulation of the degradation-resistant pE-modified Abeta in the lysosomes, lysosomal dysfunction, and neurodegeneration.'], ['As a consequence of perturbed CNP expression, mice show secondary low-grade inflammation/neurodegeneration.'], ['SIRT1 is involved not in only longevity due to caloric restriction but in a variety of diseases such as diabetes, cardiovascular dysfunction and neurodegeneration.'], ['The disease burden imposed on families is enormous including decision making in relation to presymptomatic diagnosis for late onset neurodegenerative disorders and reproductive choices.'], ['BACKGROUND: Lumbar spinal stenosis (LSS) with neurogenic intermittent claudication is one of the most common degenerative spinal diseases in the elderly.'], ['Oxidative stress and mitochondrial damage are implicated in the evolution of neurodegenerative diseases.'], ['In neurodegenerative disorders of the aging population, misfolded proteins, such as PrP(Sc), alpha-synuclein, amyloid beta protein and tau, can interact resulting in enhanced aggregation, cross seeding and accelerated disease progression.'], ['Basically, SIRTs are mediators of aging process, they have the potential of ameliorating and taking part in important cellular processes associated, such as metabolic homeostasis, tumorigenesis and cancer cell proliferation, inflammatory disorders, cardiovascular diseases and neurodegeneration.'], ['This author has proposed that diabetes-evoked copper dysregulation is an important new target for therapeutic intervention to prevent/reverse organ damage in diabetes, heart failure, and neurodegenerative diseases, and that triethylenetetramine (TETA) is the first in a new class of anti-diabetic molecules, which function by targetting these copper-mediated pathogenic mechanisms.'], ['Voluntary runners are subjected to a massive increase in reactive oxygen/nitrogen species production, which can promote different oxidative stress-related diseases such as premature aging, neurodegenerative disorders, and cancer.'], ['BACKGROUND: ageing is highly associated with neurodegeneration and atrophy of the brain.'], ['Defect in mitochondrial dynamics lead to various pathologies, including several common and some rare neurodegenerative disorders.'], ['This may be due to poor vision limiting performance on cognitive tasks specifically requiring vision, or an association between visual and neurodegenerative disorders.'], ['A pathobiological cascade of biochemical events in the presence of CBH that leads to oxidative stress and neurodegeneration appears to involve multiple biofactors including micronutrients, trace metals, lipids, and pro-oxidants, as reviewed in this special issue of BioFactors.'], ['Microglial activation is a significant contributor to the pathogenesis of many neurodegenerative diseases.'], ['BACKGROUND: Atherosclerosis is a chronic and degenerative disease developing typically in the elderly; nonetheless, a condition of accelerated atherosclerosis can be observed precociously in the presence of some diseases.'], ['Glaucoma, a group of intraocular pressure-related optic neuropathies, is characterized by the slow progressive neurodegeneration of retinal ganglion cells and their axons, resulting in irreversible visual sensitivity loss and blindness.'], ['These altered responses may have particular relevance to neurodegenerative diseases of aging.'], ["Parkinson's disease (PD) is the second most common neurodegenerative disease in the world, and oxidative stress plays an important role in its pathogenesis."], ['Inflammation integrates diverse mechanisms that are associated not only with pathological conditions, such as cardiovascular diseases, type 2 diabetes, obesity, neurodegenerative diseases and cancer, but also with physiological processes like reproduction i.e.'], ['In mammals, autophagy is involved in antigen presentation, tolerance, inflammation and protection against neurodegenerative diseases.'], ["Alzheimer's disease (AD) is the most common neurodegenerative illness affecting the elderly and is characterized by beta-amyloid (Abeta) deposition in the brain (plaques) and in microvessels (Abeta-angiopathy)."], ['Aging increases the risk to develop several neurodegenerative diseases, although the underlying mechanisms are poorly understood.', 'These observations unveil that Bmi1 genetic deficiency recapitulates aspects of physiological brain aging and that Bmi1 over-expression is a potential therapeutic modality against neurodegeneration.'], ['Previous studies have highlighted that GSTM1 has a role in neurodegenerative disorders, but no data have associated the GSTM1 gene with AD risk.'], ["Parkinson's disease is one of the most common neurodegenerative disorders associated with aging, reaching ~ 2% of individuals over 65 years."], ["Within the last few years, there has been a growing interest in the neuroprotective effects of estrogen and the possible beneficial effects of estrogen in neurodegenerative diseases such as stroke, Alzheimer's disease, and Parkinson's disease."], ['Plenty of evidence supports the utility of melatonin in adults for cancer, neurodegenerative disorders, and aging.'], ['After controlling for age and sex, EPS was associated with outdoor occupational activity (age and sex adjusted odd ratio [ORa], 2.22; 95% CI, 1.31-3.37) and with degenerative disorders such as pinguecula (ORa, 1.48; 95% CI, 1.15-1.89) but not with inflammatory disorders such as blepharitis or dry eye.'], ['This study indicates that with the neurodegeneration associated with PD, telomeric and subtelomeric structural alterations occur.'], ['Studies of retinal neurodegeneration have shown alterations in KYNA synthesis in the retina in response to retinal ganglion cell loss.', 'In summary, these findings point to the potential involvement of KYNA in the mechanisms of retinal aging and neurodegeneration.'], ['Such outcomes underlie numerous pathologies, including, but not limited to, carcinogenesis and neurodegeneration, as well as the aging process.'], ['The prevalence of epilepsy increases with age, and mitochondrial oxidative stress is a leading mechanism of aging and age-related degenerative disease, signifying a further involvement of mitochondrial dysfunction in seizure generation.'], ['Human neurodegenerative diseases have the temporal hallmark of afflicting the elderly population.', 'To understand this connection it is necessary to identify the pathways that functionally integrate ageing, chronic maintenance of the brain and modulation of neurodegenerative disease.', 'Here we report that the conserved miRNA miR-34 regulates age-associated events and long-term brain integrity in Drosophila, providing a molecular link between ageing and neurodegeneration.', 'Whereas mir-34 loss triggers a gene profile of accelerated brain ageing, late-onset brain degeneration and a catastrophic decline in survival, mir-34 upregulation extends median lifespan and mitigates neurodegeneration induced by human pathogenic polyglutamine disease protein.'], ['Because binding patterns predict future cognitive decline and increase over time along with clinical decline, [(18)F]FDDNP PET scanning may have practical utility in identifying people at risk for future cognitive decline and in tracking the effectiveness of novel interventions designed to prevent or delay neurodegeneration and cognitive decline.'], ["Alzheimer's disease and dementia with Lewy bodies are the most common neurodegenerative dementias in old age."], ["In this review, we provide an overview of the literature on DNA methylation in neurodegenerative diseases, with a special focus on methylation of 5-position of cytosine base (5mC) and hydroxymethylation of 5-position of cytosine base (5hmC) in the context of neurodegeneration associated with aging and Alzheimer's disease."], ['Moreover, alterations in the genes coding for isoprenylated proteins or enzymes that are involved in both prenylation and maturation processes have been found to be the basis of severe human diseases, such as cancer, neurodegenerative disorders, retinitis pigmentosa, and premature ageing syndromes.'], ["BACKGROUND: Alzheimer's disease (AD) is the most common neurodegenerative disorder in the aging population and is characterized by extracellular plaques in the brain."], ['[(18)F]Flutemetamol-positive MCI subjects showed a large variability in hippocampus volumes, indicating that these subjects were in different stages of neurodegeneration.'], ['Increased oxidative stress has been incriminated in physiological conditions, such as aging and exercise, and in several pathological conditions, including cancer, neurodegenerative diseases, cardiovascular diseases, diabetes, inflammatory diseases, and intoxications.'], ['Among the medical problems, vision (cataract) and degenerative joint disease top the list, followed by neurological problems.'], ['The main primary safety end-point is symptomatic intracerebral haemorrhage defined as any hemorrhage at the 22-36 h post-treatment scan combined with neurological deterioration leading to an increase of one or more points at the National Institutes of Health Stroke Scale.'], ["On the other hand, the resistance of monkeys and apes to tauopathy and AD-related neurodegeneration, in the presence of substantial cerebral Abeta deposition, suggests that a comparative analysis of human and nonhuman primates could yield informative clues to the uniquely human predisposition to Alzheimer's disease."], ['Neurodegenerative diseases (NDs) are some of the most debilitating human illnesses.', 'Research over the past 10 years has provided evidence for a common mechanism of neurodegeneration in which the critical event is the brain accumulation of misfolded protein aggregates.', 'To understand the molecular basis of NDs and to develop therapeutic strategies against them, numerous transgenic rodent models have been produced, which reproduce some (but not all) of the features of these diseases.', 'Importantly, some NDs are not exclusive to human beings, such as transmissible spongiform encephalopathies.'], ["Alzheimer's disease (AD) is a complex neurodegenerative disorder and is the most common form of dementia in the elderly."], ['Autophagy defects are linked to diseases, such as liver failure, neurodegeneration, inflammatory bowel disease, aging and cancer.'], ['Electric lifting chair is a typical assistive product to aid for standing up and sitting down for persons with disability, and it is particularly useful for the elderly persons whose muscular system is weakened by degenerative joint disease.'], ['Cartilage defects, most commonly caused by aging and degenerative disease, have become the primary target of cartilage tissue engineering due to a lack of effective treatments and limited regenerative abilities.', 'In this review, we will summarize some potential factors resulting in cell senescence during cartilage tissue engineering, including ex vivo expansion, donor age, and degenerative diseases, and the challenge in the identification of senescent cells.'], ['Due to these two actions, CoQ(10) is commonly used in clinical practice in chronic heart failure, male infertility, and neurodegenerative disease.'], ["Alzheimer's disease (AD) is a progressive neurodegenerative disease that affects a staggering percentage of the aging population and causes memory loss and cognitive decline."], ['Intake of these fruits may help to prevent age-related neurodegeneration and resulting changes in cognitive and motor function.'], ['OBJECTIVE: : To clarify at which age and at what point in the postoperative period neurological deterioration occurs in patients with cervical spondylotic myelopathy.'], ['Frontotemporal Lobar Degeneration (FTLD) is the most frequent neurodegenerative disorder with a presenile onset.'], ['The degenerative disorders that affect elderly patients dominate the landscape of surgical care in Japan.'], ["An important component of future proactive healthcare is the detection of changes in the individual's physical or cognitive performance, especially for aging and for those with neurodegenerative diseases."], ["In the last twenty years, there has been increased evidence that AGEs could be implicated in the development of chronic degenerative diseases of aging, such as cardiovascular disease, Alzheimer's disease and with complications of diabetes mellitus."], ['The causes and severity of memory impairment in the elderly are diverse, however, so any given case might not necessarily be secondary to a neurodegenerative disorder such as Alzheimer disease.'], ["The most common neurodegenerative disorder afflicting the aging human population is Alzheimer's disease (AD)."], ['Transactive response DNA-binding protein (TARDBP/TDP-43), a heterogeneous nuclear ribonucleoprotein (hnRNP) with diverse activities, is a common denominator in several neurodegenerative disorders, including amyotrophic lateral sclerosis and frontotemporal lobar degeneration.', 'Loss of tdp-1 suppressed defects in transgenic C. elegans expressing TDP-43 or CuZn superoxide dismutase, both of which are associated with proteotoxicity in neurodegenerative diseases.'], ['Altered function of Cdk5 kinase is associated with many forms of neurodegenerative disease in humans.', 'We show here that inactivating the Drosophila Cdk5 ortholog, by mutation of its activating subunit, p35, causes adult-onset neurodegeneration in the fly.', 'Many of these phenotypes are also characteristic of mammalian neurodegenerative disease, suggesting a close relationship between the mechanisms of Cdk5-associated neurodegeneration in fly and human.'], ["Magnetic resonance (MR) provides a non-invasive way to investigate changes in the brain resulting from aging or neurodegenerative disorders such as Alzheimer's disease (AD).", 'We demonstrated the validity of the method for use in clinical studies which provides an alternative to well established techniques to compare different imaging biomarkers for the study of neurodegenerative diseases.'], ['AIMS: There is a growing interest in the understanding of a possible role of DNA repair systems in ageing and neurodegenerative diseases after DNA damage is observed in the brain of individuals affected by neurodegenerative diseases.'], ['The diet in the elderly does not provide a sufficient level of nutrients needed to maintain an adequate healthy status leading to micronutrient deficiencies and impaired immune response with subsequent development of degenerative diseases.'], ["Alzheimer's disease (AD) is a complex neurodegenerative disorder that diverges from the process of normal brain aging by unknown mechanisms."], ["Since then, increasing evidence has indicated that resveratrol may be useful in treating cardiovascular diseases, cancers, pain, inflammation, tissue injury, and in reducing the risk of neurodegenerative disorders, especially Alzheimer's disease (AD).", 'AD is characterized by a progressive dementia, and is one of the most common neurodegenerative disorders in the elderly.'], ["Alzheimer's disease (AD) is the most common form of dementia in the elderly individuals and is associated with progressive neurodegeneration of the human neocortex."], ["However, as a result of the increase in life expectance, neurodegenerative diseases like Alzheimer's and Parkinson's (AD and PD, respectively) are becoming an increasing burden, as aging is their main risk factor.", 'Brain aging and neurodegenerative diseases of the elderly are characterized by oxidative damage, dysregulation of redox metals homeostasis and inflammation.', 'This review will present salient features of the beneficial multi-pharmacological actions of black and green tea polyphenols in aging and neurodegeneration, and speculate on their potential in drug combination to target distinct pathologies as a therapeutic disease modification approach.'], ['Postmenopausal women have an elevated risk of developing a neurodegenerative disease.', 'A deeper understanding of the molecular mechanisms common to all forms of neurodegenerative diseases may hasten the development of protective strategies against chronic age-related deterioration and acute illness, ultimately providing a better quality of life for the elderly.'], ['In addition, aging greatly increases the risk of neurodegenerative disease.'], ['The incidence and prevalence of neurodegenerative diseases (ND) increase with life expectancy.', 'This paper reviews the role of oxidative stress (OS) in ND and pharmacological attempts to fight against reactive oxygen species (ROS)-induced neurodegeneration.', 'Several mechanisms involved in ROS generation in neurodegeneration have been proposed.', 'Since it is necessary to look for genes as the ultimate controllers of all biological processes, this paper also tried to identify gerontogenes involved in OS and neurodegeneration.', 'Since neurons depend on glial cells to survive, recent articles about the functioning of these cells in aging and ND were also reviewed.', 'Although several potential drugs have been screened in in vitro and in vivo models of ND, these results were not translated in benefit of patients, and disappointing results were obtained in the majority of clinical trials.'], ['While rapamycin has been in use for years in transplant patients as an antirejection drug, more recently it has shown promise in treating diseases of aging, such as neurodegenerative disorders and atherosclerosis.', 'In addition to its role in HGPS and normal aging, we discuss the potential of rapamycin for the treatment of age-dependent neurodegenerative diseases.'], ['Decline of these processes is thought to contribute to aging and neurodegenerative diseases.'], ['The recent suggestion of prion-like propagation of neurodegeneration and the finding of neurodegeneration being quite common in middle-aged persons is alarming.'], ['The stimulant effect of methylphenidate has been used for the treatment of major depression, poststroke depression, cognitive enhancement in patients with brain tumors, neurodegenerative disorders, HIV disease, fatigue, and as a treatment for delirium and sedation associated with opioid use.'], ['BACKGROUND: The role of intra- and extra-cranial venous system impairment in the pathogenesis of various vascular, inflammatory and neurodegenerative neurological disorders, as well as in aging, has not been studied in detail.'], ['An important precondition for the successful development of diagnostic assays of cerebrospinal fluid (CSF) biomarkers of age-related neurodegenerative diseases is an understanding of the dynamic nature of the CSF proteome during the normal aging process.'], ["The emergence of longevity in the modern world has brought a sense of urgency to understanding age-related neurodegenerative diseases such as Alzheimer's disease.", 'Unfortunately, there is a lack of consensus regarding the correlation between the pathological substrates of neurodegeneration and dementia status, particularly in the oldest-old.'], ['This article is part of a Special Issue entitled: Imaging Brain Aging and Neurodegenerative disease.'], ['Motor activity of Caenorhabditis elegans is widely used to study the mechanisms ranging from basic neuronal functions to human neurodegenerative diseases.', "Using this system, we identified an adult-onset, ageing-associated motor activity loss in a transgenic nematode line expressing human pathogenic G2019S mutant LRRK2 (leucine-rich repeat kinase 2), the leading genetic cause of Parkinson's disease characterized by dopaminergic neurodegeneration associated motor deficient mainly in elder citizens."], ['Modulation of endogenous cellular defense mechanisms represents an innovative approach to therapeutic intervention in diseases causing chronic tissue damage, such as in neurodegeneration.', 'This paper describes in mechanistic detail how hormetic dose responses are mediated for endogenous cellular defense pathways including sirtuin, Nrfs and related pathways that integrate adaptive stress responses in the prevention of neurodegenerative diseases.'], ['The fifth U.K. meeting on nuclear envelope disease and chromatin brought together international experts from across the field of nuclear envelope biology to discuss the advancements in a class of tissue-specific degenerative diseases called the laminopathies.'], ['RESULTS AND CONCLUSIONS: Epidemiological and prospective studies have related vitamin D deficiency with not only osteoporosis but also cardiovascular disease, diabetes, cancer, infections and neurodegenerative disease.'], ['Parkinson disease (PD) is one of the most common chronic neurodegenerative diseases of the elderly, and it is likely that as populations age PD will become even more prevalent and more of a public health burden.'], ['The etiology of single unprovoked seizure was as follows: stroke, 77 cases (50.3%); cryptogenic, 36 (23.5%); alcoholism, 10 (6.6%); a combination of several causes such as polypathology, 9 (5.9%); degenerative disease, 6 (4.0%); HIV infection, 2 (2.0%), and undetermined causes (2.7%).'], ['In this work, we used standardized thalamic volumetry combined with diffusion tensor imaging, T2 relaxometry, and lesion mapping on large cohorts of controls (N = 255, age range = 6.2-69.1 years) and MS patients (N = 109, age range = 20.8-68.5 years) to demonstrate early age- and lesion-independent thalamic neurodegeneration.'], ['The percentage of elderly people, and consequently the incidence of age-related diseases such as heart disease, cancer, and neurodegenerative diseases, is projected to increase considerably in the coming decades.'], ['Amyotrophic lateral sclerosis (ALS) is the third most common human adult-onset neurodegenerative disease.', 'Nevertheless, the mechanisms of neurodegeneration in ALS are unresolved.', 'Genetic, biochemical, and morphological analyses of human ALS as well as cell and animal models of ALS reveal that mitochondria could have roles in this neurodegeneration.', 'Transgenic mouse models of ALS reveal possible principles governing the biology of neurodegeneration that implicate mitochondria and the mitochondrial permeability transition pore.', 'This paper reviews how mitochondrial pathobiology might contribute to the mechanisms of neurodegeneration in ALS.'], ['Monoamine oxidase (MAO) catalyzes the oxidative deamination of biogenic and exogenous amines and its inhibitors have therapeutic value for several conditions including affective disorders, stroke, neurodegenerative diseases and aging.'], ["In many chronic diseases, including atherosclerosis, several malignancies, neurological disorders, autoimmune diseases, aging, age-related degenerative diseases, and Wilson's disease, the concurrent zinc deficiency may complicate the clinical features, affect adversely immunological status, increase oxidative stress, and lead to the generation of inflammatory cytokines."], ['CSF biomarkers are consistent with disease trajectories predicted by beta-amyloid cascade (Hardy, J Alzheimers Dis 2006;9(Suppl 3):151-3) and tau-mediated neurodegeneration hypotheses for AD, whereas brain atrophy and hypometabolism levels show predicted patterns but exhibit differing rates of change depending on region and disease severity; (3) the assessment of alternative methods of diagnostic categorization.'], ['Parkinson disease is a progressive neurodegenerative disease that affects, among other neurotransmitter systems, the nigrostriatal dopaminergic projection.'], ["Aluminium, iron and copper are all implicated in the aetiology of neurodegenerative diseases including Alzheimer's disease.", 'and overall tissue iron contents were generally high which possibly reflected increased brain iron in ageing and in neurodegenerative disease.', 'and overall tissue copper contents were lower than expected for aged brains but they were commensurate with aged brains showing signs of neurodegenerative disease.', 'When these values are subtracted from tissue digest values the absolute metal contents could be considered as conservative and yet they may still reflect aspects of ageing and neurodegenerative disease in individual brains.'], ['We are reviewing the literature and discuss what can be expected regarding the translation into clinical practice and how the findings can be extended to other neurodegenerative diseases with protein aggregation in brain.'], ['The histopathologic findings include degenerative lesions, fissures, interstitial edema without cellular infiltration, necrosis and neovascularization.'], ['Oxidatively damaged DNA is implicated in various diseases, including neurodegenerative disorders, cancer, diabetes, cardiovascular and inflammatory diseases as well as aging.'], ['One half-century later in life, this pattern of reversals is mirrored in ageing and in neurodegeneration.'], ['Prion diseases are a family of unique fatal transmissible neurodegenerative diseases that affect humans and many animals.'], ["Parkinson's disease (PD) is the most frequent neurodegenerative movement disorder and manifests at old age."], ['Because cobalamin utilization is dependent on its efficient transit through lysosomes, and mounting evidence indicates that lysosomal function deteriorates in aging long-lived post-mitotic cells such as neurons, in the present article we review published data that supports the proposition that impaired lysosomal processing of cobalamin may play a significant role in age-related (neuro) degenerative diseases.'], ['The characteristics of aging in natural animals strongly suggest that the so-called chronic degenerative diseases of humans are not really diseases but actually manifestations of the aging phenotype.'], ['This article is part of a Special Issue entitled: Imaging Brain Aging and Neurodegenerative disease.'], ['In this review we outline the unique characteristics of mitochondrial genetics before detailing important pathological features of mtDNA diseases, focusing on adult neurological disease as well as the role of mtDNA mutations in neurodegenerative diseases, ageing and cancer.'], ['This article is part of a Special Issue entitled: Imaging Brain Aging and Neurodegenerative disease.'], ['To understand whether brain aging contributes to the vulnerability of midbrain to neurodegeneration in PD compared to striatum, we assessed the status of oxidant and antioxidant markers, glutathione metabolic enzymes, glial fibrillary acidic protein (GFAP) expression and mitochondrial complex I(CI) activity in SN (n = 23) and caudate nucleus (n = 24) during physiological aging in human brains.'], ["Alzheimer's disease (AD) is a progressive neurodegenerative disease involving the decline of memory and other cognitive functions."], ['Elderly subjects with advanced dementia are exposed, like all aging individuals, to a wide range of chronic degenerative and progressive medical conditions which can cause pain and discomfort, both physical and psychological.'], ["Pre-lamin A and progerin have been implicated in normal aging, and the pathogenesis of age-related degenerative diseases is termed 'laminopathies'."], ['Regenerative medicine using spluripotent/multipotent stem cells holds a great promise in developing therapies for treating developmental abnormalities, degenerative disorders, and aging-related illness.'], ['Inflammation accompanied by severe oxidative stress plays a vital role in the orchestration and progression of neurodegeneration prevalent in chronic and acute central nervous system pathologies as well as in aging.', 'Our studies suggest that TNFalpha-mediated activation of Mg(2+) -nSMase and NOX in neuronal cells not only produced the neurotoxic intermediates ceramide and ROS but also directly antagonized neuronal survival mechanisms, thus accelerating neurodegeneration.'], ['Moreover, since elevated proteasome capacity results in improved clearance of toxic huntingtin fragments in a yeast model for neurodegenerative diseases, we speculate that the observed lifespan extension originates from prolonged elimination of damaged proteins in old mother cells.'], ['This article is part of a Special Issue entitled: Imaging Brain Aging and Neurodegenerative disease.'], ['Aging is a major risk factor for the progression of neurodegenerative diseases, including Huntington disease (HD).', 'To determine whether Irs2 signaling modulates neurodegeneration in HD, we genetically modulated Irs2 concentrations in the R6/2 mouse model of HD.'], ['On the other hand, an abdominal aortic aneurysm (AAA) represents an age-related degenerative disorder.'], ['Neurodegeneration describes the loss of neuronal structure and function.', 'Numerous neurodegenerative diseases are associated with neurodegeneration.', 'However, the prevalence of major neurodegenerative diseases is increasing with improvements in treating major diseases such as cancers and cardiovascular diseases, resulting in an aging population.', 'The neurological consequences of neurodegeneration in patients can have devastating effects on mental and physical functioning.', 'The causes of most cases of prevalent neurodegenerative diseases are unknown.', 'The role of neurotoxicant exposures in neurodegenerative disease has long been suspected, with much effort devoted to identifying causative agents.', 'In this review, the role of environmental neurotoxicant exposures on neurodegeneration in selected major neurodegenerative diseases is discussed.', 'The special sensitivity the nervous system exhibits to toxicant exposure and unifying mechanisms of neurodegeneration are explored.'], ["Many factors, including the aging process, can cause proteasome impairment leading to formation of abnormal ubiquitin-protein aggregates that are found in most progressive neurodegenerative diseases, including Alzheimer's and Parkinson's diseases.", 'In addition, they can be used to identify compounds potentially capable of preventing a decline in proteasome activity and formation of ubiquitin-protein aggregates associated with neurodegeneration.'], ['They target the factors that damage mitochondria and reverse its effect, thus eliminating the imbalance seen in energy production and restore the normal cellular function, making these antioxidants very powerful alternate strategies for the treatment of cardiovascular cerebrovascular as well as neurodegenerative diseases including AD.'], ["The beginnings of late onset Alzheimer's disease (LOAD) are still unknown; however, the progressive and latent nature of neurodegeneration suggests that the triggering event occurs earlier in life.", 'Aging primates exposed to lead (Pb) as infants exhibited an overexpression of the amyloid-beta protein precursor (AbetaPP), amyloid-beta (Abeta) and enhanced pathologic neurodegeneration.', 'Hence, we deduce that early life exposure to Pb can reprogram gene expression resulting in both upregulation and down-regulation of genes through alternate epigenetic pathways contributing to an enhancement in neurodegeneration in old age.'], ["Alzheimer's disease (AD) is a progressive, neurodegenerative disorder and the most prevalent senile dementia."], ['Patients with idiopathic RBD, particularly those with abnormal subclinical features seen in the synucleinopathies such as decreased striatal dopamine transporters uptake, are the ideal population to be tested with disease-modifying agents in order to stop or slow down neurodegeneration in the brain.'], ['Ageing of populataion world wide has significant contribution as one of the major risk factor for neurodegenerative disorders.'], ['The pathophysiologic mechanisms that cause neurodegeneration resulting in cognitive decline, including protein deposition and neuroinflammation, also play a role in animal models of surgery-induced cognitive decline.', 'With the aging of the population, surgical candidates of advanced age with underlying neurodegeneration are encountered more often, raising concerns that, in patients with this combination, cognitive function will precipitously decline postoperatively.'], ['Research topics included: perinatal asphyxia, aging and the origin of adulthood neurodegenerative disease, neuroprotective strategies, biochemical pulmonology, intrauterine growth retardation and perinatal teratology.'], ['OBJECTIVES: Loss of smell accompanies specific neurodegenerative diseases and may facilitate the early detection of these.'], ['Metabolism-based therapy has been used successfully in the treatment of seizures but study of its use in other neurodegenerative disorders is growing.'], ["Alzheimer's disease (AD) is an age-related progressive neurodegenerative disease affecting thousands of people in the world and effective treatment is still not available."], ['INTRODUCTION: Although white matter hyperintensities (WMHs) are prevalent in the elderly, the clinical significance and the underlying pathophysiological mechanisms of WMHs in neurodegenerative disorders have not been fully clarified.'], ['The molecular mechanisms of aging are the subject of much research and have facilitated potential interventions to delay aging and aging-related degenerative diseases in humans.'], ['White matter injury may be secondary to a range of neurodegenerative disorders, such as the common dementing disorders of the elderly, or may be a consequence of specific white matter disorders, such as multiple sclerosis and the rare leukodystrophies.'], ['We conducted a placebo-controlled study to examine joint and independent effects of estradiol and elevated levels of the stress hormone cortisol on cognition and biomarkers of aging and neurodegenerative disease.'], ["Neurodegenerative diseases (in particular Alzheimer's disease, AD) do also show a strong age-dependent increase in incidence and prevalence among the elderly population."], ['On the basis of these results, modulation of mTORC1 function is a promising target for the development of therapeutics for neurodegenerative diseases and HGPS.'], ['Age is the most important risk factor for neurodegeneration; however, the effects of aging and neurodegeneration on gene expression in the human brain have most often been studied separately.', 'In conclusion, the alternative splicing changes identified in this study provide a new link between aging and neurodegeneration.'], ['BACKGROUND: Corpora amylacea (CAm) are a hallmark of aging and neurodegeneration.', 'CONCLUSIONS: Expression of KAT III in CAm in the human retina and optic nerve indicates that this enzyme may be relevant in mechanisms of neurodegeneration leading to CAm formation.'], ['Recent research suggests a central role for inflammatory mechanisms in cognitive decline that may occur prior to evidence of neurodegeneration.'], ['This effect is matched by profound impacts on age related diseases including reduced risk of cancer, neurodegenerative disorders, autoimmune disease, cardiovascular disease and type II diabetes mellitus.'], ['Psychiatric disorders in the elderly are often related to cerebral neurodegeneration and cerebrovascular disease, although psychosocial risk factors are also important.'], ['Previous research studies have related the insertion/deletion (I/D) polymorphism of the angiotensin I converting enzyme (ACE) gene to cognitive function in various neuropsychiatric or neurodegenerative disorders, but not yet investigated its genetic association with specific cognitive domains.'], ['It has been implicated in many human neurodegenerative diseases, as well as in ageing.'], ['Alzheimer disease (AD) is a neurodegenerative disorder characterized by progressive decline of cognitive function that represents one of the most dramatic medical challenges for the aging population.'], ['Increased aggregation of misfolded proteins is associated with aging, and characterizes a number of neurodegenerative disorders caused by homopolymeric amino acid expansion mutations.'], ['Herbal antioxidants are gradually gaining importance as dietary supplements considering the growing implications of oxidative stress in most degenerative diseases and aging.'], ['Increased generation of ROS/RNS is implicated in the pathogenesis of a variety of human diseases, including neurodegenerative disease, atherosclerosis, cancer, and aging.'], ['This article is part of a Special Issue entitled: Imaging Brain Aging and Neurodegenerative disease.'], ['INTERPRETATION: These findings suggest that APOEepsilon4 allele(s) may show antagonistic pleiotropy on cognition and brain atrophy in SN controls, but may lead to premature aging with neurodegeneration in younger HIV patients prior to the development of HAND.'], ['CONCLUSIONS: To avoid underestimate the severity of the degenerative spine disorder, it thus seems important to recognize the different compensatory mechanisms from the upper part of the trunk to the lower limbs.'], ['As a type of metabolic stress, dietary restriction (DR) is also known to extend life span and increase resistance to age-related neurodegenerative diseases.'], ['Recent reports have demonstrated an association between impaired tubulin acetyltransferase activity and neurodegenerative disease; viewed in this light, our results showing age-dependent accumulation of the SIRT2 neuronal MT deacetylase in wild-type mice suggest a functional link between tubulin acetylation patterns and the aging brain.'], ['Considering the many differences between mice and humans, it is perhaps surprising how well mice model late-onset human neurodegenerative disease.'], ["It is widely accepted that inflammation plays some role in the progression of chronic neurodegenerative diseases such as AD (Alzheimer's disease), but its precise role remains elusive.", 'Therefore a better understanding of how delirium occurs during dementia and how these episodes impact on existing neurodegeneration are now important priorities.'], ['This article is part of a Special Issue entitled: Imaging Brain Aging and Neurodegenerative disease.'], ['OBJECTIVE: This study determined whether CGG repeat length moderates the relationship between age and performance on selective measures of executive function in premutation carriers (PM) who are asymptomatic for a recently described late-onset neurodegenerative disorder, fragile X-associated tremor/ataxia syndrome (FXTAS).'], ['The high prevalence of pruritic inflammatory skin disorders in elderly patients is a consequence of three physiological changes that occur with aging: (1) the epidermal barrier repair is diminished; (2) the immune systems of elderly patients are activated and have defective Th1 function along with enhanced Th2 function (immunosenescense); and (3) neurodegenerative disorders may lead to pruritus by their central or peripheral effects.'], ["Tauopathies, including Alzheimer's disease are the most frequent neurodegenerative disorders in elderly people."], ['Here we summarize evidence to show how progeroid syndromes, integrated with other models, can be valuable tools in addressing questions about the role of stem cell aging in human degenerative diseases of older age and the molecular pathways involved.'], ['Investigation of the pathophysiology and therapies for CAA-associated hemorrhages have been made possible through animal models utilizing species that develop CAA in a similar fashion to humans, such as the squirrel monkey, rhesus monkey, dog and mutant and transgenic mouse strains, which exhibit the age-related development of amyloid plaques, progressive neurodegeneration and CAA-associated hemorrhages.'], ['Aging is a physiologic state in which a progressive decline of organ functions may be accompanied by developing age-related diseases and neurodegenerative diseases.', 'Several reports demonstrate that mitochondria play a key role in aging and some neurodegenerative diseases.', 'In this review we summarize the role of mitochondria dysfunction occurring in aging and neurodegenerative disease, describing novel mitochondria-targeted therapy approach and the new selective molecules and nanocarriers technology as potentially effective in targeting mitochondrial dysfunction.'], ['Topics discussed included the natural history and clinical features of the diseases, clinical and laboratory diagnosis of these rare diseases, therapeutic strategies, mouse models of neurodegeneration, molecular analysis of accelerated aging, impact of transcriptional defects and mitochondrial dysfunction on neurodegeneration, and biochemical insights into mechanisms of NER and base excision repair.'], ['Advances in therapy have also increased the prevalence of patients with chronic and degenerative diseases.'], ['Tauopathies are neurodegenerative disorders characterized by the accumulation of abnormal tau protein leading to cognitive and/or motor dysfunction.'], ['During the repair process, one of the challenges is neurodegeneration, which can develop from interrupted innervations to/from the targets, chronic inflammation, ischaemia, aging or idiopathic neural toxicity.', 'Neurodegeneration, which occurs on the basis of a characteristic vascular and neural web, usually presents as a chronically progressive process with unknown aetiology.', 'Currently, there is no effective treatment to stop or slow down neurodegeneration.', 'We discuss how the blood-brain barrier and neural networks are formed to maintain CNS homeostasis and their contribution to neurodegeneration in diseased conditions.'], ['Iron deposition in the human brain tissue occurs in the process of normal aging and in many neurodegenerative diseases.'], ['We focus on Apolipoprotein D (ApoD), a Lipocalin expressed by glia and strongly induced upon aging, injury or neurodegeneration.'], ['Both TS and DS brains show earlier aging and neurodegeneration.'], ["Alzheimer's disease (AD) is a progressive neurodegenerative disorder of the elderly accounting for the vast majority of dementia."], ['By contrast, ablation of Pin1 prevents cancer, but eventually leads to premature ageing and neurodegeneration.'], ["In this article, we resume the main strides in these fields, mainly aiming at delivering an exhaustive portrait of SOD's involvement in several oxidative stress-triggered threats to human health, including neurodegenerative disorders (amyotrophic lateral sclerosis, Alzheimer's, Parkinson's and Huntington's diseases), cardiovascular diseases, cancer and aging."], ['The aging process and the presence of degenerative diseases lead to losses of strength and proprioceptive acuity.'], ["Alzheimer's disease (AD) is a common neurodegenerative disorder that affects cognitive function in the elderly and has associated genetic variation within the diseased genome."], ['These findings have significant clinical implications for control of swallowing across the age span and in neurodegenerative disease.'], ['The EE paradigm has been proposed as a non-invasive treatment for alleviating age-related memory impairment and neurodegenerative diseases.', 'Results obtained in preclinical models of EE may be relevant to future research into mental and neurodegenerative diseases, stress, aging and development of enviromimetics.'], ['Furthermore, age has a powerful effect on enhanced susceptibility to neurodegenerative diseases and age-dependent enhanced neuroinflammatory processes may play an important role in toxin generation that causes death or dysfunction of neurons in neurodegenerative diseases This review will address current understanding of the relationship between ageing, neuroinflammation and neurodegenerative disease by focusing on the principal mechanisms by which the immune system influences the brain plastic phenomena.', "Also, the present review considers the principal human neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis, multiple sclerosis and psychiatric disorders caused by aging and neuroinflammation."], ["Since basal forebrain cholinergic neurons represent one major neuronal population affected and progressively degenerating in Alzheimer's disease (AD), interest has grown for NGF as a potential therapeutic agent in neurodegenerative disorders linked to aging, particularly for AD.", 'The results obtained with the AD11 anti-NGF mice highlight the fact that the particular mode of NGF neutralization, with an NGF antibody expressed in the brain, selectively interfering with mature NGF versus unprocessed proNGF, plays a major role in the mechanism of neurodegeneration, and could lead to new insights into the mechanisms of human sporadic AD.'], ['Although our results suggest unchanged unconscious FER processing with increasing cognitive impairment, further investigations on unconscious FER and self-awareness of FER capacity in neurodegenerative disorders are required.'], ['Our results suggest that algorithmic approach and graph metrics might be used to identify and track neurodegenerative diseases, however more studies will be needed to evaluate utility of this type of analysis for different disease states.'], ['BACKGROUND: Asymmetric cortical myoclonus is typically thought to be associated with either contralateral cortical structural lesions or degenerative disorders such as corticobasal degeneration when onset is in middle-aged or aged adults.'], ['Intracellular oxidative stress that damages cellular components can contribute to lifestyle-related diseases such as diabetes and arteriosclerosis, and age-related diseases such as cancer and neuronal degenerative diseases.'], ["In this context, neurodegenerative pathologies such as Alzheimer's disease (AD) account for a major part of these protein misfolding diseases."], ["Parkinson's disease (PD), dementia with Lewy bodies (DLB) and multiple system atrophy (MSA) are adult onset neurodegenerative disorders characterised by prominent intracellular alpha-synuclein aggregates (alpha-synucleinopathies).", 'The glial contribution to neurodegeneration in alpha-synucleinopathies was largely underestimated until recently.', 'Accumulating experimental evidence in PD models suggests that astrogliosis and microgliosis act as important mediators of neurodegeneration playing a pivotal role in both disease initiation and progression.'], ['As people age, memory and the ability to carry out tasks often decline and their risk for neurodegenerative diseases increases.'], ['Oxidative stress has been implicated in aging and many human diseases, notably neurodegenerative disorders and various cancers.'], ['Considering the advantage offered by the MMN paradigm used here, these data might be a useful reference point for the assessment of auditory sensory memory in pathological aging (e.g., in neurodegenerative diseases).'], ['INTRODUCTION: Degenerative spine disorders are steadily increasing parallel to the aging of the population with considerable impact on cost and productivity.'], ["BACKGROUND: One of the hallmarks of Alzheimer's disease, and several other degenerative disorders such as Inclusion Body Myositis, is the abnormal accumulation of amyloid precursor protein (APP) and its proteolytic amyloid peptides."], ['Of these, most (48%) were in "stage 3", which corresponds to amyloid pathology with early neurodegeneration.'], ['In this review, the effects of dietary polyphenols on the prevention and/or mitigation of cancer, neurodegenerative diseases, obesity, metabolic syndrome and atherosclerosis will be illustrated.'], ['Toxic effects of aggregated tau and/or dysfunction of soluble tau could both contribute to neural defects in these neurodegenerative diseases.'], ['Basic and clinical researchers in disciplines from central nervous system injury/stroke, mental/addictive disorders, paediatric/developmental disorders and neurodegeneration/ageing identified cardinal examples of neuroplasticity, underlying mechanisms, therapeutic implications and common denominators.'], ['Discovery of human induced pluripotent stem (hiPS) cells has opened new avenues for the treatment of degenerative diseases using patient-specific stem cells to generate tissues and cells for autologous cell-based therapy.'], ["Parkinson's disease (PD) is a late-onset neurodegenerative disease which occurs at more than 1% in populations aging 65-years and over."], ["BACKGROUND: Parkinson's disease (PD) is a chronic neurodegenerative disease expected to cause great costs."], ['Aggregation-prone polyglutamine (polyQ) expansion proteins cause several neurodegenerative disorders, including Huntington disease.'], ['RESULTS: Stroke and neurodegenerative disorders account for most causes of epilepsy in older patients.'], ["Many promising new therapies are progressing through preclinical and clinical development, and offer the potential of improved treatment options for neurodegenerative diseases such as Alzheimer's disease (AD) as well as other disorders that have not been particularly well treated to date like the cognitive impairments associated with schizophrenia (CIAS)."], ['PD is an age-related neurodegenerative disorder that affects as many as 1-2% of persons aged 60 years and older.'], ['Targeting of FOXO factors has also been proposed for the treatment of metabolic dysfunctions such as diabetes mellitus, immunological disorders and neurodegeneration, as well as for the prevention of aging by maintaining the hematopoyetic stem cells niche.'], ['Also, chronic inflammation is closely associated with cardiovascular disease, as well as a broad spectrum of neurodegenerative diseases of aging including AD.'], ['Neurodegenerative diseases are disabling conditions continuously increasing due to aging of population.'], ['To ensure a wide range of EF, 48 participants with diverse neurodegenerative disorders and 21 older neurologically normal ageing participants were included.'], ["Numerous data are now available on the beneficial properties of the polyphenolic compound resveratrol (3,5,4'-trihydroxy-stilbene) including its anti-inflammatory, antioxidant and antitumor effects, its role in the aging process and in the prevention of heart and neurodegenerative diseases."], ['Further studies have described the distribution and etiology of neurodegenerative disease in the population, and determined pathological correlates of cognitive impairment and dementia.'], ['DNA damage plays a major role in various pathophysiological conditions including carcinogenesis, aging, inflammation, diabetes and neurodegenerative diseases.'], ['During mammalian aging, misframed versions of human amyloid precursor protein (hApp) and ubiquitin (hUbb) accumulate in the aggregates characteristic of neurodegenerative diseases, suggesting dysfunctional degradation or clearance.'], ["There is strong evidence that the amyloid-beta peptide (Abeta) plays a crucial role in the pathogenesis of Alzheimer's disease (AD), a lethal neurodegenerative disorder of the elderly."], ["Parkinson's disease (PD) is a common neurodegenerative disease resulting from complex interaction involving genetic and environmental risk factors on background of aging."], ['In a variety of organs, including the skeleton, mutations in components of antioxidant defense pathways have been found to lead to progressive degenerative diseases.'], ["Alzheimer's disease (AD), the most common neurodegenerative disease associated with aging, is still an incurable condition."], ['Maintaining genomic integrity is critical to avoid life-threatening disorders, such as premature aging, neurodegeneration and cancer.'], ["Also discussed are the intriguing phenotypic similarities between s-IBM muscle fibers and the brains of Alzheimer and Parkinson's disease patients, the two most common neurodegenerative diseases associated with ageing."], ["The supplementation of creatine has shown a marked neuroprotective effect in mouse models of neurodegenerative diseases (Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis).", 'As aging and neurodegeneration share pathophysiological pathways, we investigated the effect of oral creatine supplementation on aging in 162 aged wild-type C57Bl/6J mice.'], ["Brain iron increases with age and is abnormally elevated early in the disease process in several neurodegenerative disorders that impact memory including Alzheimer's disease (AD)."], ['This article summarizes the scope of epilepsy in elderly people, highlights cerebrovascular and neurodegenerative diseases as the main underlying etiologies, explores the diagnostic challenges in this age group, including the hurdles and processes in their investigation, and examines pertinent clinical management issues.'], ["Today, Alzheimer's disease (AD) is one of the most important age-related neurodegenerative diseases, but its etiology remains still unknown.", 'Aggresome formation is also observed in other neurodegenerative diseases, suggesting that an activation of similar mechanisms must occur in neurodegeneration as a basic phenomenon.'], ['Mild parkinsonian signs (MPS) may represent the mild end of a disease spectrum that spans from normal aging to neurodegenerative diseases.'], ['Since ApoD shares many properties with the common ancestor of invertebrate Lipocalins, we must benefit from this global comparison with both GLaz and NLaz to understand the complex functions of ApoD in mammalian aging and neurodegeneration.'], ['These results suggest a potential broader role for the peroxisome in cellular aging and the initiation of age-related degenerative disease.'], ['Osteoarthritis is a degenerative joint disease characterized by the thinning and eventual wearing of articular cartilage, and affects millions of people worldwide.'], ['The beneficial properties of the polyphenolic compound resveratrol including its anti-inflammatory, antioxidant, and antitumor effects, its role in the aging process and in the prevention of heart and neurodegenerative diseases are well-known.'], ["During the last century, the world population has shown a staggering increase in its proportion of elderly members and thus, neurodegenerative diseases like Alzheimer's and Parkinson's diseases (AD and PD, respectively) are becoming an increasing burden.", 'Brain aging and neurodegenerative diseases of the elderly are characterized by oxidative damage, dysregulation of redox metals homeostasis and inflammation, supporting a therapeutic use of antioxidants.', 'The scope of this review is to assess and put into perspective salient features of the beneficial brain action of natural, non-toxic green tea catechins in aging-impaired cognition and neurodegenerative diseases and to discuss a scenario concerning their potential, in drug combination, to target distinct pathologies, in the quest for a disease modifying therapy.'], ['TAR DNA-binding protein 43 (TDP-43) plays a key role in the neurodegenerative diseases including amyotrophic lateral sclerosis and frontotemporal lobar degeneration.', 'These results suggest that protein misfolding underlies the aging-dependent neurodegeneration associated with TDP-43 and that the insulin/IGF-1 signaling may be a target for therapies.'], ['BACKGROUND: RBD is a parasomnia that can develop in otherwise neurologically-normal adults as well as in those with a neurodegenerative disease.'], ["Alzheimer's disease is a neurodegenerative disease that is imposing an increasing burden on society, and is the leading cause of senile dementia worldwide."], ['Valvular heart disease remains frequent in industrialised countries since the decrease in frequency of rheumatic heart diseases has been accompanied by an increase in degenerative valve diseases.'], ['BACKGROUND: Hippocampal sclerosis (HpScl) in the elderly is often associated with neurodegeneration.'], ['OBJECTIVE: Neurodegeneration is now accepted as a pathologic hallmark of multiple sclerosis (MS).', 'Evaluation of NfH(SMI35) levels is likely to provide a useful surrogate for measuring the rate of neurodegeneration in MS.'], ['With the aging population in the Western hemisphere, neurodegenerative parkinsonism and dementia will become two of the great public health challenges of this century.', 'It has become clear that factors other than neurodegeneration affect alphaS concentrations in these tissue samples, such as genetic and environmental influences.'], ["Alzheimer's disease (AD) is a neurodegenerative disorder that affects the elderly population."], ["Alzheimer's disease (AD) is the fastest growing neurodegenerative disease in the elderly population, and the search for therapeutic targets and diagnostic AD biomarkers is an exigent issue."], ['Oxidative stress plays a central role in the pathogenesis of diverse chronic inflammatory disorders including diabetic complications, cardiovascular disease, aging, neurodegenerative disease, autoimmune disorders, and pulmonary fibrosis.'], ['Alzheimer disease (AD), a progressive neurodegenerative disorder, is the most common cause of dementia in the elderly.'], ['Amyotrophic lateral sclerosis (ALS) is an idiopathic, fatal neurodegenerative disease of the human motor system.', 'We focus on what is known about ALS and where research is heading-from the small steps of extending longevity, improving therapies, undertaking clinical trials, and compiling population registries to the overarching goals of establishing the measures that guard against onset and finding the triggers for this neurodegenerative disorder.'], ['PNP correlated significantly with markers for vascular disease as well as immune activation (homocysteine and neopterin) similar to earlier findings in patients with neurodegenerative disorders, suggesting common therapeutic options in patients with PNP and dementia.'], ["There are a number of neurodegenerative diseases that cause dementia, including Alzheimer's disease, dementia with Lewy bodies, and frontotemporal dementia, which is subdivided into the behavioral variant, the semantic variant, and nonfluent variant.", 'All of the major neurodegenerative disorders have relatively specific imaging findings that can be identified.', 'New imaging techniques carry the hope of revolutionizing the diagnosis of neurodegenerative disease so as to obtain a complete molecular, structural, and metabolic characterization, which could be used to improve diagnosis and to stage each patient and follow disease progression and response to treatment.'], ['Valvular heart disease remains common in industrialized countries, because the decrease in prevalence of rheumatic heart diseases has been accompanied by an increase in that of degenerative valve diseases.'], ['The accumulation of unhealthy mitochondria results in mitochondrial dysfunction, which has been implicated in aging, cancer, and a variety of degenerative diseases.'], ['Malfunctioning autophagy is observed in many human diseases including cancer, neurodegenerative diseases, cardiac and muscular diseases, infectious and inflammatory diseases, diabetes, and obesity.'], ['Mitochondrial dysfunction has severe cellular consequences and is linked with neurodegenerative diseases and aging.'], ['Parkinson disease (PD) is second only to Alzheimer disease as the most common neurodegenerative disorder in humans.'], ['In conclusion, NPD1 bioactivity potently down regulates inflammatory signaling, amyloidogenic APP cleavage and apoptosis, underscoring the potential of this lipid mediator to rescue human brain cells in early stages of neurodegenerations.'], ['The main causes of a reduced range of motion are degenerative joint diseases and increased stiffness of collagen tissue.'], ["beta-N-methylamino-L-alanine (BMAA) is routinely described in the literature as a potent neurotoxin and as a possible cause of neurodegenerative disorders of aging such as Alzheimer's disease, amyotrophic lateral sclerosis, and the amyotrophic lateral sclerosis/parkinsonism-dementia complex (ALS-PDC) syndrome of Guam.", 'Because there are no known natural sources of BMAA that would make consumption of such amounts possible, and because the toxicity observed was in the same range as the nutritional supplement beta-alanine, the hypothesis that BMAA is an environmental hazard and a contributor to degenerative neurological diseases becomes untenable.'], ['This is mainly attributed to the loss of synaptic connectivity, which is a feature commonly observed in neurodegenerative disorders.'], ['Traditionally, OA has been viewed as a degenerative joint disease characterized by progressive destruction of the articular cartilage and changes in the subchondral bone culminating in joint failure.'], ["Alzheimer's disease (AD), a progressive neurodegenerative disorder, is the leading cause of dementia in the elderly."], ['Notably, accumulation of isomerized proteins could contribute to metabolic dysfunctions in neuronal cells during aging reducing cognitive functions in elderly patients and would eventually promote the development of neurodegenerative diseases.', 'In this review, we summarize recent findings, based mostly on proteomic data, regarding the formation and accumulation of proteins bearing atypical L-isoaspartyl residues as well as PIMT functions during normal aging and in some neurodegenerative diseases.'], ['Mitochondria, which convert energy for the cell, accumulate damage with age, and the resulting mitochondrial dysfunction has been linked to the development of degenerative diseases and aging.'], ["Activation of innate immune mechanisms leading to pro-inflammatory cytokine up-regulation is involved in devastating and disabling human brain illnesses, as Alzheimer's disease (AD), a progressive neurodegenerative disease that causes dementia in the elderly."], ['CONCLUSIONS: This is the first study to correlate neurodegeneration in different populations of cells in the ageing retinas.'], ['More importantly, we introduce for the first time in a degenerative disorder an application of a recently developed tensor index, the "mode" of anisotropy, as well as probabilistic crossing-fibre tractography.', 'Finally, the methods used in this study may have general applicability for other degenerative disorders and, beyond the clinical sphere, they could contribute to a better quantification and understanding of subtle effects generated by normal processes such as visuospatial attention or motor learning.'], ["Studies in peripheral lymphocytes of patients with neurodegenerative diseases, mainly Alzheimer's disease (AD) and Parkinson's disease (PD), revealed an increased micronucleus (MN) frequency in both disorders but originating mainly from chromosome malsegregation events in AD and from chromosome breakage events in PD.", "Studies in other neurodegenerative diseases are largely missing, and some data in premature ageing disorders characterised by neurodegeneration and/or neurological complications, such as Ataxia telangiectasia, Werner's syndrome, Down's syndrome (DS) and Cockayne's syndrome, indicate that MNi increase with ageing in cultured cells."], ['Motivating this effort is the idea that marginal micronutrient deficiencies lead to allocation of scarce cellular resources towards immediate survival at the expense of maintaining genomic integrity, placing the individual at greater risk for degenerative diseases and cancer in old age.'], ['The rate of major complications in this study (12.1%) compares favorably to that reported from other studies of surgery for degenerative deformity.'], ["Alzheimer's disease (AD) is the most prevalent neurodegenerative disease of the elderly and is characterized by regional specificity of neural aberrations associated with higher cognitive functions."], ["The most frequently occurring ailments that are connected with neurodegeneration are: Alzheimer's disease, Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis, and multiple sclerosis.", 'In this review, we present current opportunities of neuroimaging techniques in the diagnosis and differentiation of neurodegenerative disorders.'], ['In contrast, in patients with mild cognitive impairment (MCI, a prodromal stage of AD), and early forms of AD, apparently no cholinergic neurodegeneration but a loss of cholinergic function occurs.'], ['The role of oxidative stress and the beneficial effects of wine polyphenols against cardiovascular, cancer, diabetes, microbial, inflammatory, neurodegenerative and kidney diseases and ageing are reviewed.'], ["Normal aging also imposes a robust constraint on the onset of many neurological diseases, ranging from late onset neurodegenerative diseases, such as Alzheimer's (AD) and Parkinson's diseases (PD), to early onset psychiatric disorders, such as bipolar disorder (BPD) and schizophrenia (SCZ)."], ['BACKGROUND: Worldwide, degenerative eye diseases (age-related maculopathy (ARM), cataract, glaucoma) are the main causes of visual impairment and blindness, which contribute to disability in the elderly.'], ['Finally, BNIP3 and NIX are implicated in mitochondrial quality control, which is important in aging and degenerative disease.'], ['For example, they imply that organismal senescence is a disease process with a broad spectrum of pathological consequences in late life (causing or exascerbating cardiovascular disease, cancer, neurodegenerative disease and many others).'], ["Late onset is a common hallmark character of numerous disorders including human neurodegenerative maladies such as Huntington's, Parkinson's and Alzheimer's diseases.", 'Here, we review these novel studies and discuss the potential of ageing alteration as a therapeutic approach for the treatment of late onset neurodegeneration.'], ['We describe our experience of oxygen-ozone therapy to treat degenerative spine disease in the elderly.', 'The good results obtained indicate that oxygen-ozone therapy is an ideal treatment with no side-effects in elderly patients with degenerative spine disease.'], ["Dementia with Lewy bodies (DLB) and Parkinson's Disease (PD) are neurodegenerative disorders of the aging population characterized by the abnormal accumulation of alpha-synuclein (alpha-syn).", 'Previous studies have suggested that excitotoxicity may contribute to neurodegeneration in these disorders, however the underlying mechanisms and their relationship to alpha-syn remain unclear.'], ['A group of growth factors have been shown to play important roles in amelioration of the malfunction of the neurodegenerative diseases.', 'These results suggest that the rectal non-invasive delivery of the P11 polypeptide-conjugated growth factor is an efficient way for BBB transduction, thus raises the hope of real therapeutic progress against neurodegenerative diseases.'], ["OBJECTIVES: Senescence of the immune system and of endothelial cells can contribute to age-dependent vascular and neurodegenerative disorders including Alzheimer's disease.", 'The aim of this study is an assessment of putative relationships of serum levels of transforming growth factor beta (TGFbeta) and soluble endoglin (sCD105) and neurodegeneration, and of changes of these molecules in the course of ageing.'], ['Despite the abundance and apparent capacity of chaperones and other components of homeostasis to restore folding equilibrium, the cell appears poorly adapted for chronic proteotoxic stress which increases in cancer, metabolic and neurodegenerative diseases.', 'Pharmacological modulation of cellular stress response pathways has emerging implications for the treatment of human diseases, including neurodegenerative disorders, cardiovascular disease, and cancer.', 'This paper describes in mechanistic detail how hormetic dose responses are mediated for endogenous cellular defense pathways, including the possible signaling mechanisms by which the carnitine system, by interplaying metabolism, mitochondrial energetics and activation of critical vitagenes, modulates signal transduction cascades that confer cytoprotection against chronic degenerative damage associated to aging and neurodegenerative disorders.'], ['Thus, isozyme-specific, hPHS-dependent oxidative damage and cytotoxicity caused by neurotransmitters, their precursors, and their metabolites may contribute to neurodegeneration associated with aging.'], ['This process is characterized by accumulation of dysfunctional autophagy-lysosomal vesicles, a compromise of these vesicles leading to damage of intracellular membranes and organelles, necrotic-like intraneuronal destruction and neurodegeneration.'], ['Laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) has been developed and established as an emerging technique in the generation of quantitative images of metal distributions in thin tissue sections of brain samples (such as human, rat and mouse brain), with applications in research related to neurodegenerative disorders.'], ['RESULTS: Among patients with degenerative spinal disease, men had significantly longer rehabilitation stays than women (P < 0.001).', 'Men with degenerative spinal disease had significantly lower discharge Functional Independence Measure scores than women, indicating more dependence in self-care (P < 0.001) and mobility (P < 0.001).', 'Among patients with degenerative spinal disease, men were less likely to walk (odds ratio = 0.58; 95% CI = 0.38-0.87) and less likely to be independent with bladder management (odds ratio = 0.44; 95% CI = 0.31-0.62).', 'Men were more dependent than women at discharge in the etiology group with the least overall disability (degenerative spinal disease) and more independent in mobility than women at discharge in the etiology group with the most overall disability (vascular ischemia).'], ['Positive allosteric modulators of AMPA receptors could provide a therapeutic approach to the treatment of cognitive disorders resulting from aging and/or neurodegenerative diseases, such as Alzheimer disease (AD).'], ['Alzheimer disease (AD) is the most common causes of neurodegenerative disorder in the elderly individuals.'], ['Increased oral intake of iron in the neonatal period leads to a progressive age-related enhancement of dopaminergic neurodegeneration associated with paraquat neurotoxicity.', 'Furthermore, neurodegeneration associated with these combined genetic and environmental risk factors could be attenuated by systemic treatment with the bioavailable antioxidant compound EUK-189.', "These data suggest that environmental factors previously identified as contributors to neurodegeneration associated with sporadic Parkinson's disease may also be candidates for observed variations in symptoms and disease progression in monogenic forms and that this may mechanistically involve increased levels of oxidatively-induced post-translational nitration of alpha-synuclein."], ['Even though a systematic knowledge of placebo effects across the lifespan is lacking, we aim at highlighting specific aspects related to the care of elderly patients and those suffering from neurodegenerative diseases.'], ['Oxidative stress causes damage to multiple cellular components such as DNA, proteins, and lipids, and is implicated in various human diseases including cancer, neurodegeneration, inflammatory diseases, and aging.'], ["Our results highlight the importance of controlling encoding conditions between groups and of taking account of other variables that may influence the participants' performance, such as deficits associated with normal aging, which may mask deficits in neurodegenerative diseases in particular situations."], ['CAA plays an important role in the multimorbid condition of the ageing brain but its contribution to neurodegeneration remains to be elucidated.'], ['GENERAL SIGNIFICANCE: Better comprehension of the mechanism of neurodegeneration in rare recessive disorders, such as neuronal ceroid-lipofuscinoses, is likely to help to better understand mechanisms involved in more complex genetic neurodegenerative conditions, such as those associated with aging.'], ['Because of related health and social impact, there is growing interest in assessing potential relationship between anesthesia and the onset and progression of chronic neurodegenerative disorders, including AD.', 'Currently, preclinical and clinical research is addressed to identify underlying pathomechanisms, patient risk factors, and the use of the least provocative drugs and techniques, to minimize the incidence of chronic neurodegenerative disorders.', 'Therefore, risk factors and pathomechanisms of chronic neurodegenerative disorders, including AD, and persistent postoperative-postanesthesia cognitive dysfunction may overlap.'], ["Oxidative stress, which plays a critical role in the pathogenesis of neurodegenerative diseases such as Alzheimer's disease (AD), is intimately linked to aging, the best established risk factor for AD."], ["BACKGROUND: Human brain aging has received special attention in part because of the elevated risks of neurodegenerative disorders such as Alzheimer's disease in seniors.", 'Recent technological advances enable us to investigate whether similar mechanisms underlie aging and neurodegeneration, by quantifying the similarities and differences in their genome-wide gene expression profiles.', 'CONCLUSIONS: This study establishes a quantitative scale for measuring premature aging in neurodegenerative disease cohorts, and it identifies specific physiological mechanisms common to aging and some forms of neurodegeneration.'], ['Additionally, it has a crucial role in the prevention and treatment of several chronic-degenerative diseases, especially diabetes mellitus. }'], ['Neurofibrillary tangles (NFTs), which consist of highly phosphorylated tau, are hallmarks of neurodegenerative diseases including Alzheimer disease (AD).', 'In neurodegenerative diseases, neuronal dysfunction due to neuronal loss and synaptic loss accompanies NFT formation, suggesting that a process associated with NFT formation may be involved in neuronal dysfunction.'], ['Vascular and neurodegenerative disease commonly cooccur in older persons.'], ['Some mechanisms for this increase are aging; autoimmunity; congenital, metabolic and degenerative disorders; and AIDS.'], ['Therefore, a subtle preoperative radiological diagnosis is warranted and surgery should be performed by experienced hands to avoid neurological deterioration.'], ["Aging is the primary risk factor of neurodegenerative disorders such as Alzheimer's disease (AD)."], ['Many research teams are dealing with the mechanisms of the neurodegeneration.'], ['Neurodegenerative disorders are some of the most feared illnesses in modern society, with no effective treatments to slow or halt this neurodegeneration.', "Several decades after the earliest attempt to treat Parkinson's disease using caffeine, tremendous amounts of information regarding the potential beneficial effect of caffeine as well as adenosine drugs on major neurodegenerative disorders have accumulated.", 'In the first part of this review, we provide general background on the adenosine receptor signaling systems by which caffeine and methylxanthine modulate brain activity and their role in relationship to the development and treatment of neurodegenerative disorders.', 'This is followed by an outline of the major mechanism underlying neuroprotection against neurodegeneration offered by caffeine and adenosine receptor agents.', "In the second part, we discuss the current understanding of caffeine/methylxantheine and its major target adenosine receptors in development of individual neurodegenerative disorders, including stroke, traumatic brain injury Alzheimer's disease, Parkinson's disease, Huntington's disease and multiple sclerosis.", "The exciting findings to date include the specific in vivo functions of adenosine receptors revealed by genetic mouse models, the demonstration of a broad spectrum of neuroprotection by chronic treatment of caffeine and adenosine receptor ligands in animal models of neurodegenerative disorders, the encouraging development of several A(2A) receptor selective antagonists which are now in advanced clinical phase III trials for Parkinson's disease.", 'Importantly, increasing body of the human and experimental studies reveals encouraging evidence that regular human consumption of caffeine in fact may have several beneficial effects on neurodegenerative disorders, from motor stimulation to cognitive enhancement to potential neuroprotection.', 'Thus, with regard to neurodegenerative disorders, these potential benefits of methylxanthines, caffeine in particular, strongly argue against the common practice by clinicians to discourage regular human consumption of caffeine in aging populations.'], ["These findings support the fact that pre-existing dementia is frequent in patients with intracerebral haemorrhage and may be the consequence of two different mechanisms: neurodegeneration with Alzheimer's disease and cerebral amyloid angiopathy in lobar intracerebral haemorrhage versus vascular process in deep intracerebral haemorrhage."], ['Human neurodegenerative maladies share two common key features: a mechanistic link to the accumulation and deposition of aberrantly aggregated proteins and late onset.', 'Invertebrate-based studies have shown that the manipulation of aging by the reduction of the Insulin/IGF signaling (IIS), a prominent aging regulatory pathway, protects model organisms from neurodegeneration-linked toxic protein aggregation.', 'In this article I review the current knowledge on the protective mechanisms that are suppressed by the IIS and discuss the future therapeutic potential of IIS reduction as a treatment for neurodegenerative disorders.'], ['In the mammalian brain, p53 plays critical functions in normal development, tumor suppression, neurodegenerative diseases, and aging.', 'Herein, we focus on the constitutive pro-oxidant activity of p53 in neurons and discuss the potential implication of this finding in the context of neurodegenerative diseases and normal brain aging.'], ["Alzheimer's disease (AD) is the most common neurodegenerative disorder among the elderly, and early detection is of great importance if new therapies are to be effectively administered."], ['Thirty-day mortality in patients undergoing primary elective mitral repair for degenerative disease was 5.1% (2/39).', 'CONCLUSION: Elective mitral repair can be performed with low operative mortality and good long-term outcomes in selected octogenarians with degenerative mitral disease, and is associated with better long-term survival than mitral replacement.', 'The survival benefit associated with surgery for non-degenerative disease is more questionable.'], ['Lack of uniformity of clinical manifestations, the variety of vascular diseases and circulatory factors, the diverse, but often convergent, neuropathological substrates, and the common association with unrelated neurodegenerative diseases in the elderly, make it hard to assume a single clinical approach in the diagnosis and treatment of cognitive impairment of vascular origin.', 'Rather, environmental and genetic risk factors, underlying vascular diseases, associated systemic, metabolic and neurodegenerative diseases and identification of extent and distribution of lesions with morphological and functional neuroimaging methods should be applied in every individual patient.'], ["BACKGROUND: Alzheimer's disease (AD) is a major neurodegenerative disorder leading to amnesia, cognitive impairment and dementia in the elderly."], ['It is well known that calorie restriction (CR) can retard the aging process in organisms ranging from yeast to non-human primates, and delay the onset of numerous age-related diseases including neurodegenerative disorders.', 'Signaling pathways induced by CR are therefore potentially new therapeutic targets for neurodegenerative diseases.', 'We focus in particular on recent findings on sirtuins for prevention of neurodegenerative diseases.'], ["More recently, it became clear that aging is the major known risk factor for several neurodegenerative disorders, such as Alzheimer's disease, Parkinson's disease and Huntington's disease.", 'Here, we review how sirtuins contribute for aging and, in particular, for neurodegeneration and how they are becoming attractive targets for therapeutic intervention.'], ['Mitochondrial dysfunction is a common hallmark of ageing-related diseases involving neurodegeneration.', "Huntington's disease (HD) is one of the most common monogenetic forms of neurodegenerative disorders and shares many salient features with the major sporadic disease of neurodegeneration, such as amyotrophic lateral sclerosis (ALS), Alzheimer's disease (AD) and Parkinson's disease (PD).", 'Recent evidence from the study of transgenic and knockout animal models of HD has stimulated new perspectives on mitochondrial dysfunction in HD and possibly other neurodegenerative diseases.', 'Hence, mitochondrial and transcriptional dysregulation in HD - previously thought to be unrelated mechanisms of neurodegeneration - appear to be directly linked at the molecular level.'], ['Recent evidence posits that mitochondrial abnormalities in this neurodegenerative disorder are associated with changes in mitochondrial dynamics and can be induced by amyloid-beta (Abeta) that progressively accumulates within this organelle, acting as a direct toxin.'], ["It is known that elderly people suffer from cognitive impairment, even without neurodegeneration, as a part of 'normal aging'."], ['New data and literature review are provided evaluating the role of LPO in the pathophysiology of ageing and classically oxidative stress-linked diseases, such as neurodegenerative diseases, diabetes and atherosclerosis (the main cause of cardiovascular complications).'], ["Our hypothesis is that there is 'wear and tear' in the brain, which is the basis of the process of aging, but that stimulation of brain function may slow down brain aging and diminish the risk for neurodegenerative diseases such as Alzheimer's disease (AD), possibly by activating repair mechanisms."], ["Disease severity can also be assessed by increased levels of CSF phospho-tau protein and the ratio of phospho-tau to Abeta (1-42), which might be a useful tool for predicting conversion of NPH individuals to other neurodegenerative disorders including Alzheimer's disease (AD)."], ['Longer years in education were associated with decreased dementia risk and greater brain weight but had no relationship to neurodegenerative or vascular pathologies.', 'More education did not protect individuals from developing neurodegenerative and vascular neuropathology by the time they died but it did appear to mitigate the impact of pathology on the clinical expression of dementia before death.'], ["Thus manganese occupational and dietary overexposure has been shown to cause progressive, permanent, neurodegenerative damage, resulting in syndromes similar to idiopathic Parkinson's disease."], ['The significant prognostic factors were old age, degenerative disease, multiple-level fusion and male.', 'The likelihood of a second operation was high in those with old age, degenerative disease, multiple-level fusion and male.'], ['A parallel literature describes an elevated list of chronic degenerative disease as common in such patients including neurodegenerative conditions, atherosclerosis, nephrosclerosis, hepatic fibrosis and cirrhosis, chronic obstructive and fibrotic lung disease, osteoporosis, chronic periodontitis, various cancers, hair greying, and stem cell suppression.', 'The link between the immunostimulation on the one hand and the elevated and temporally advanced nature of the chronic degenerative diseases on the other appears not to have been made in the literature.'], ['Furthermore, the overlap with the risk haplotype recently reported for frontotemporal dementia provides further evidence of a shared genetic cause for these two neurodegenerative diseases.'], ['To validate the shift in serum N-glycan profile during ageing, we studied serum N-glycan profiles in different age groups of healthy volunteers, patients with dementia, and patients with Cockayne syndrome, a genetic DNA repair disorder involving neurodegeneration and premature ageing.'], ['Epidemiologic data suggest that people who develop neurodegenerative diseases of aging have a decreased risk of cancer.', 'This is intriguing, since there is growing evidence that neurodegeneration and carcinogenesis share a number of biological pathways, such as abnormal entry into the cell cycle.', 'We review the role of Pin1 in cancer and neurodegeneration, discuss the relationship between Pin1 and aging, and explore its potential as a diagnostic and therapeutic target.'], ['Aging and several neurodegenerative diseases bring about changes in the anatomy and physiology of the choroid plexus.'], ['Among these age-related diseases, neurodegenerative diseases have drawn a lot of attention due to their irreversibility, lack of effective treatment, and accompanied social and economical burdens.', "In this review, we discuss the pathogenesis of age-related neurodegenerative diseases including Alzheimer's disease, Parkinson's disease and cerebrovascular disease."], ['In mice, deficiency for the Sir2 family member SIRT6 leads to genomic instability, metabolic defects and degenerative pathologies associated with aging.'], ['Optical coherence tomography (OCT) is a new method that could aid analysis of neurodegeneration in multiple sclerosis (MS) by capturing thinning of the retinal nerve fibre layer (RNFL).'], ['Fibrillar protein aggregates are the major pathological hallmark of several incurable, age-related, neurodegenerative disorders.', 'Our results suggest that MOAG-4/SERF regulates age-related proteotoxicity through a previously unexplored pathway, which will open up new avenues for research on age-related, neurodegenerative diseases.'], ['Moreover, the pathogenesis of age-associated diseases such as epithelial skin cancer and neurodegenerative diseases has been partly attributed to the lack of hormones.'], ['Reactive oxygen and nitrogen species play a critical role in many degenerative diseases and in aging.'], ['Functional and structural MRI studies have increased our understanding of the underlying neurobiological mechanisms of aging and neurodegeneration, but the use of neuroimaging to investigate the effect of cognitive intervention on the brain remains largely unexplored.'], ["Autophagy is associated with tumorigenesis, neurodegenerative diseases, cardiomyopathy, Crohn's disease, fatty liver, type II diabetes, defense against intracellular pathogens, antigen presentation, and longevity."], ['Strikingly, these insoluble proteins are highly over-represented in aggregates found in human neurodegeneration.', 'Together our findings indicate that widespread protein insolubility and aggregation is an inherent part of aging and that it may influence both lifespan and neurodegenerative disease.'], ["Brain iron promotes neurodegeneration in Parkinson's disease (PD)."], ['BACKGROUND: Mitochondrial DNA (mtDNA) haplogroups and single nucleotide polymorphisms (mtSNP) have been shown to play a role in various human conditions including aging and some neurodegenerative diseases, metabolic diseases and cancer.'], ['Increasing evidence from research on several diseases show that oxidative stress is associated with the pathogenesis of diabetes, obesity, cancer, ageing, inflammation, neurodegenerative disorders, hypertension, apoptosis, cardiovascular diseases, and heart failure.'], ['Early life nutritional programming, as well as neurodevelopment may protect against neurodegeneration.'], ['Successful applications of this method include determining changes in the proteasomal activities during aging, anti-aging interventions, cell cycle analysis, and in various disease states including neurodegenerative diseases and cancers.'], ["Mitochondrial dysfunction has long been implicated in the pathogenesis of neurodegenerative disorders such as Parkinson's disease and amyotrophic lateral sclerosis (ALS), and in physiological conditions such as aging.", 'Moreover, electron microscopic study has enabled us to confirm mitochondrial involvement in the pathomechanism of certain neurodegenerative diseases.'], ["Alzheimer's and Parkinson's diseases are the most common neurodegenerative disorders among the aged."], ['We recently discovered that mRGCs resist neurodegeneration in two inherited mitochondrial disorders that cause blindness, i.e.', 'We anticipate that these studies will lead to many other investigations addressing the role of mRGCs and circadian photoreception in the pathogenesis of circadian and sleep abnormalities in neurodegenerative disorders.'], ["Alzheimer's disease (AD) is a neurodegenerative disorder which results in the irreversible loss of cortical neurons, particularly in the associative neocortex and hippocampus."], ['Several genes related to neuroprotection and neurodegeneration were differentially expressed in the hypothalamus of males that continued to mate after castration.'], ['On the other hand, they cause oxidative damage of cellular DNA, protein and lipids, resulting in the initiation or development of numerous diseases such as cancer, cardiovascular diseases, type 2 diabetes mellitus, cataract, rheumatoid arthritis, or different neurodegenerative diseases.'], ['BACKGROUND: With the increase in the elderly population, a growing number of chronic degenerative diseases and a greater dependency on caregivers have been observed.'], ['It is possible to use hormetic strategies (both conditioning hormesis and postexposure conditioning hormesis) to enhance the function of repair processes in aging humans and therefore prevent age-related chronic degenerative diseases and prolong healthy lifespan.'], ['Dysregulation of autophagy, a cellular catabolic mechanism essential for degradation of misfolded proteins, has been implicated in multiple neurodegenerative diseases.'], ['Our results demonstrate that melanopsin retinal ganglion cells resist neurodegeneration due to mitochondrial dysfunction and maintain non-image-forming functions of the eye in these visually impaired patients.'], ["In fact, ROS and RNS have been implicated in the oxidative deterioration of food products, as well as in the pathogenesis of several chronic and/or ageing diseases such as atherosclerosis, diabetes mellitus, chronic inflammation, neurodegenerative disorders, including Alzheimer's disease, and certain types of cancer."], ['Mitochondria may play important roles in metabolic diseases, neurodegeneration, and aging.'], ['Failure to resolve these lesions through one or more DNA-repair processes is associated with genome instability, mitochondrial dysfunction, neurodegeneration, inflammation, aging, and cancer, emphasizing the importance of characterizing the pathways and proteins involved in the repair of oxidative DNA damage.'], ['Altered P-gp function seems to be involved in the pathophysiology of neurodegenerative disease and various neurological and psychiatric disorders.', 'In this review, we highlight changes of P-gp function, as measured with VPM-PET, in aging and in the pathogenesis and progression of neurodegenerative disease, as well as their role in depressive disorders.'], ['At hospital admission, these patients showed a significant higher prevalence of cardiovascular diseases (56.3% vs 53.4%; p = 0.007), neoplasias (32.3% vs 13.7%; p < 0.001), and lower prevalence of neurodegenerative diseases (17.7% vs 20.7%; p < 0.001) than survived patients.', 'In the overall study population, the APOE epsilon2 allele was significantly associated to neurodegenerative diseases (odds ratio = 0.59; 95% confidence interval (CI), 0.37-0.94).'], ['BACKGROUND: Lumbar spinal stenosis is a degenerative disease of the elderly population.'], ['Thus, the BER (SSBR) pathway plays a critical role in maintaining genomic integrity, and may help us to better understand the mechanisms of aging, tumor formation, and degenerative diseases.'], ["BACKGROUND: Parkinson's disease (PD), the second most frequent neurodegenerative disorder at old age, can be caused by elevated expression or the A53T missense mutation of the presynaptic protein alpha-synuclein (SNCA).", 'METHODOLOGY/PRINCIPAL FINDINGS: Here, we used two mouse lines overexpressing human A53T-SNCA and studied striatal dysfunction in the absence of neurodegeneration to understand early disease mechanisms.', 'CONCLUSIONS/SIGNIFICANCE: Taken together, the dysfunctional neurotransmission and impaired synaptic plasticity seen in the A53T-SNCA overexpressing mice reflect early changes within the basal ganglia prior to frank neurodegeneration.'], ["Accumulating evidences suggest that dopaminergic neuronal loss in the substantia nigra pars compacta (SNpc) during ageing and in Parkinson's disease (PD) is linked to neurodegenerative changes like exponential increase in alpha-synuclein expression and protein misfolding.", 'Lewy body formation is also a quintessential observation in neurodegeneration and PD.'], ['OBJECTIVE: The somatotropic axis (growth hormone [GH] and insulinlike growth factor I [IGFI]) play a role in the cognitive deficits seen with aging, GH deficiency, and neurodegenerative disorders such as Alzheimer disease.'], ['SIRT1 activation could thus constitute a potential strategic target in neurodegenerative diseases and in disorders involving disturbances in glucose homeostasis, as well as in dyslipidaemias or cardiovascular diseases.'], ["Neurodegenerative disorders, including Alzheimer's disease (AD) and Parkinson's disease (PD), are common disorders of the central nervous system among aging populations."], ['AD is caused by severe neurodegeneration in the hippocampus and neocortical regions of the brain but the cause of this neuronal loss is unclear.', 'Evidence that FAD mutations inhibit the biological functions of PS combined with absence of haploinsufficiency mutants, support a model of allelic interference where inactive FAD mutant alleles promote autosomal dominant neurodegeneration by also inhibiting the functions of wild type alleles.'], ['Patients with degenerative diseases of the cervical spine, such as ossification of the posterior longitudinal ligament, spondylosis, and canal stenosis, sometimes present with acute spinal cord injury caused by minor trauma.', 'The clinical and radiological features of 94 elderly patients with head injury, 57 men and 37 women aged from 65 to 98 years (mean 76.6 years), were retrospectively analyzed to assess the association of spinal cord injury with degenerative cervical diseases.', 'Degenerative cervical diseases were present in 25 patients, and spinal cord injury was more common in the patients with degenerative diseases (11/25 patients) than in the patients without such diseases (3/69 patients; relative risk = 10.2).', 'The incidence of degenerative cervical diseases seems to be increasing in Japan because life expectancy has increased and the elderly are a rapidly growing part of the population.'], ['Nonetheless, the status of neurodegeneration in schizophrenia is somewhat tenuous and it is possible that brain imaging studies on animal models of the disorder, which may describe progressive alterations to cortical, limbic and ventricular structures similar to those of schizophrenic patients, are necessary to resolve the issue.'], ["Parkinson's disease is the second most common neurodegenerative disease, after Alzheimer's disease, among the aging human population."], ["One of the crucial issues in actual research on memory disorders and particularly in Alzheimer's disease is the development of behavioral tasks accurately testing episodic memory, a type of memory sensitive to aging and altered early during neurodegenerative disorders."], ['Sirt1 activation is also known to be beneficial and protective in both invertebrate and mammalian models of neurodegenerative disease.', "In view of a previously documented role of CCT in modulating polyglutamine-containing protein aggregation and toxicity, we hypothesized that CCT deacetylation may also underlie Sirt1's beneficial effects in several neurodegenerative diseases precipitated by toxic aggregates."], ['Most cases seen in clinical practise are due to kyphotic deformity secondary to inflammatory, degenerative or post-traumatic disorders.'], ['Environmental enrichment has become increasingly utilized in rodent models of aging and neurodegenerative disease in order to prevent or reverse cognitive decline and neuronal dysfunction.', 'Although data from models of neurodegenerative disease are presented, primary emphasis is given to studies of aging rodents and to methodological issues (e.g., age, treatment duration, treatment type) central to the mnemonic effectiveness of enrichment treatment.'], ['It is crucial to unravel the physiological mechanisms that, being disrupted, could lead to neurodegeneration, as this knowledge could ultimately lead to the identification of novel neuroprotective strategies that could be used as therapeutics.', 'Studies exploring this idea are underway and suggest that both methylation abnormalities in AD-related genes due to disruption of mechanisms that regulate the availability of methyl groups (SAM/HCY cycle) and changes of global histone acetylation levels might play a role in neurodegeneration.'], ["Alzheimer's disease (AD) is an age-related, progressive neurodegenerative disorder that occurs gradually and results in memory, behavior, and personality changes."], ['A huge range of pathologies, including neurodegenerative diseases, cancer, diabetes and aging, have been reported to be associated with mitochondrial dysfunction.'], ['The scientific research that has been carried out on Ashwagandha and other ayurvedic herbal medicines may be classified into three major categories, taking into consideration the endogenous or exogenous phenomena that are known to cause physiological disequilibrium leading to the pathological state; (A) pharmacological and therapeutic effects of extracts, purified compounds or multi-herbal mixtures on specific non-neurological diseases; (B) pharmacological and therapeutic effects of extracts, purified compounds or multi-herbal mixtures on neurodegenerative disorders; and (C) biochemical, physiological and genetic studies on the herbal plants themselves, in order to distinguish between those originating from different habitats, or to improve the known medicinal quality of the indigenous plant.', 'Some of the major points on its use in the treatment of neurodegenerative disorders are described below.'], ["Interest in -synuclein has increased markedly following the discovery of a relationship between its dysfunction and several neurodegenerative diseases, including Parkinson's disease."], ['Machado-Joseph disease (MJD) is a late-onset neurodegenerative disorder caused by a polyglutamine (polyQ) expansion in the ataxin-3 protein.'], ['Central nervous system trauma, diseases of the nervous system, and degenerative muscle diseases often result in significant physical impairments and disability.'], ['Osteoporosis is a degenerative disease of the skeletal system, and its major complication is fracture that severely influences the living quality of the middle-aged and the aged.'], ['Biological activities of the nonhydrolyzed carnosine in the oral formulation are based on its antioxidant and antiglycating (transglycating) action that, in addition to heavy metal chelation and pH-buffering ability, makes carnosine an essential factor for preventing sight-threatening eye disorders having oxidative stress in their pathogenesis, neurodegeneration, and accumulation of senile features.'], ['Age-related mitochondrial dysfunction underlies most neurodegenerative diseases, where it is potentiated by disease-specific factors.', 'These parameters lead synergistically with the alterations of the brain aging process to typical signs of neurodegeneration in the later state of the disease, including synaptic dysfunction, loss of synapses and neurites, and finally neuronal loss.'], ["Alzheimer's disease (AD) is a severe chronic neurodegenerative disease.", 'During aging and neurodegeneration, misfolded proteins accumulate and activate the ubiquitin-proteasome system.', 'These results suggest that different mechanisms are involved in regulating the ubiquitin-proteasomal system in different neurodegenerative diseases.'], ['Dietary and pharmacological interventions that target sphingolipid metabolism should be pursued for the prevention and treatment of neurodegenerative disorders.'], ["Alzheimer's disease (AD), the most common neurodegenerative disorder, which affects more than 35 million people worldwide, is characterized by a massive accumulation of tangles and amyloid plaques."], ['Neurodegenerative pathologies associated with aging exhibit clinical and morphological features that are relatively specific to humans.'], ['Although neurodegenerative diseases are most prevalent in the elderly, in rare cases, they can also affect children.', 'CNS pathology causes mental retardation, progressive neurodegeneration, and premature death.', "Many of these features are also found in adult neurodegenerative disorders, such as Alzheimer's, Parkinson's, and Huntington's diseases.", 'The lysosomal involvement in adult neurodegenerative diseases will also be briefly described.'], ['as well as in those related with neurological degenerative diseases (Alzheimer, etc.,) or Smith-Magenis syndrome.'], ['Here we summarize our experimental studies showing that moderate ethanol preconditioning (MEP; 20-30 mM ethanol) of rat brain cultures prevents neurodegeneration due to beta-amyloid, an important protein implicated in AD, and to other neuroinflammatory proteins such as gp120, the human immunodeficiency virus 1 envelope protein linked to AIDS dementia.'], ["However, a similar causative relationship for neurodegenerative diseases, like Alzheimer's disease (AD), has not been investigated yet.", 'Conversely, a developmental immune challenge during mid-gestation, shown to preferentially mimic schizophrenia-like behavioural and neurochemical abnormalities, including impaired Reelin-mediated signaling, prevents progressive neurodegeneration, potentially linked to the immature embryonic immune system at the time of insult, which occludes long-term changes and sub-chronic elevations of inflammatory cytokines.'], ['The incidence and prevalence in those over age 65 of neurodegenerative disorders and chronic diseases, which often have deleterious effects on cognition, are rapidly increasing in western societies.'], ["Alzheimer's disease (AD) is the most common neurodegenerative disorder among the aged worldwide."], ["Parkinson's disease (PD) and amyotrophic lateral sclerosis (ALS) are the second and third most common human adult-onset neurodegenerative diseases, respectively, after Alzheimer's disease.", 'They are characterized by prominent age-related neurodegeneration in selectively vulnerable neural systems.', 'Morphological, biochemical, and genetic, as well as cell and animal model, studies reveal that mitochondria could have a role in this neurodegeneration.', 'Transgenic mouse models of human neurodegenerative disease are beginning to reveal possible principles governing the biology of selective neuronal vulnerability that implicate mitochondria and the mitochondrial permeability transition pore.', 'This review will present how mitochondrial pathobiology might contribute to neurodegeneration in PD and ALS and could serve as a target for drug therapy.'], ['BACKGROUND: Oxidative stress has been implicated in nervous system aging and the pathogenesis of amyotrophic lateral sclerosis (ALS) and other neurodegenerative disorders.'], ["Parkinson's disease (PD) is a neurodegenerative movement disorder affecting about 2% of the human population in old age.", 'L-3,4-Dihydroxyphenylalanine (L-DOPA) in combination with a peripheral aromatic amino acid decarboxylase inhibition has been the most frequently prescribed drug for alleviating symptoms of PD, but a potential contribution of L-DOPA therapy to further neurodegeneration via oxidative stress is still debated.'], ['Here, we review some of the most recent advances in the understanding of mitochondrial stress-control pathways, with a particular focus on how defects in such pathways might contribute to neurodegenerative disease.'], ['In rodents, both dietary restriction and decreased nutrient-sensing pathway activity can lower the incidence of age-related loss of function and disease, including tumors and neurodegeneration.'], ['BACKGROUND: There is a growing evidence that reactive oxygen species (ROS) may cause many pathologic conditions including chronic diseases, neurodegenerative disorders, cancer and aging.'], ['These results imply that mtDNA deletions are unlikely to play any significant role in of murine substantia nigra aging and further call for caution in using mouse models in studies of the role of mtDNA deletions in aging and neurodegeneration.'], ["Alzheimer's disease (AD) is a heterogeneous and progressive neurodegenerative disease which in Western society mainly accounts for clinical dementia.", 'Increasing evidence, support the notion that reduction of cellular expression and activity of antioxidant proteins and consequent augment of oxidative stress are fundamental causes for ageing processes and neurodegenerative diseases., including AD.'], ['Increasing obesity and geriatric populations will continue to result in an array of osteoarthritic degenerative changes such as osteophyte formation.'], ["This agent points to possible interventions for preventing neurodegenerative diseases such as cerebral ischemia, Parkinson's disease, and Alzheimer's disease, as well as for improving brain aging."], ['Classical risk factors such as rheumatic heart disease have now been overtaken by new risk factors including an ageing population, degenerative valve disease and intravenous drug use.'], ['Parkinson disease (PD) is a neurodegenerative disorder that provides a useful model for testing cell replacement strategies to rejuvenate the affected dopaminergic neural systems, which have been destroyed by aging and the disease.'], ['Many neurodegenerative disorders, diabetes, cancer and muscular and cardiovascular diseases have been associated with low CoQ(10) levels, as well as different ataxias and encephalomyopathies.'], ["Brain-derived neurotrophic factor (BDNF) regulates synaptic plasticity and neurogenesis, and BDNF plasma and serum levels have been associated with depression, Alzheimer's disease, and other psychiatric and neurodegenerative disorders."], ['AD is a progressive neurodegenerative disease, which in Western societies accounts for the majority of cases of clinical senile dementia.'], ['GSH deficiency has been observed in aging and in a wide range of pathologies, including neurodegenerative disorders and cystic fibrosis (CF), as well as in several viral infections.'], ['Since modern technology allows production of purified bilobalide with high bioavailability, bilobalide may be useful in developing therapy for diseases involving age-associated neurodegeneration.'], ['Furthermore, ageing and neurodegenerative disorders exaggerate microglial responses following stimulation by systemic immune stimuli such as peripheral inflammation and/or infection.'], ['The accumulation of DNA damage has been widely implicated in premature aging and neurodegeneration.', 'Moreover, most of the major neurodegenerative diseases are characterized by the accumulation of neuronal DNA damage, suggesting that impaired DNA repair mechanisms might be relevant to both premature aging and neurodegeneration.', "Increasing evidence also suggests that an impaired DNA repair, particularly the base excision repair pathway, might play a fundamental role in the development of age-related neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis and Huntington' s disease.", 'Here, we review the current knowledge on the role of DNA repair in premature aging and neurodegenerative diseases.'], ["Parkinson's disease (PD) is the second most common neurodegenerative disorder, marked by progressive increases in movement-related disability, impaired balance, and nonmotor symptoms."], ['The ability to detect mitochondrial DNA (mtDNA) variation within human cells is important not only to identify mutations causing mtDNA disease, but also as mtDNA mutations are being increasingly described in many ageing tissues and in complex diseases such as diabetes, neurodegeneration and cancer.'], ['It represents a new model for inducing neuroinflammation and suggests that increasing GSH levels in glial cells may confer neuroprotection in neurodegenerative diseases, such as Alzheimer disease, which have a prominent neuroinflammatory component.'], ['Patients suffering from XP exhibit exquisite sun sensitivity, high incidence of skin cancer, and in some cases neurodegeneration.'], ['Recent advances using genetically manipulated mouse models demonstrate that selenoproteins offer protection against neurodegeneration primarily through redox regulation.'], ['In rodent models, signaling by Nrf2 defends against oxidative stress and aging-associated disorders, such as neurodegeneration, respiratory diseases, and cancer.', 'However, despite the pro-longevity and antioxidant roles of stress-activated Cnc factors, their activity paradoxically declines in aging model organisms and in humans suffering from progressive respiratory disease or neurodegeneration.'], ['During the past few years, increasing knowledge of these cells has indicated that astrocytes are pivotal characters in neurodegenerative diseases and brain injury.', 'Finally, we will briefly discuss the emerging view of astrocytes as essential characters in neurodegenerative diseases, and how a better understanding of the action of flavonoids might open new avenues to develop therapeutic approaches to these pathologies.'], ["Alzheimer's disease (AD) is a neurodegenerative disorder characterized by cognitive decline with loss of memory."], ["Alzheimer's disease (AD) is a progressive, degenerative disorder of the brain and the most common form of dementia among the elderly."], ['In general, autophagy acts as a cell protector and its dysfunction is correlated with diverse pathologies, such as neurodegeneration, liver, heart and muscle diseases, cancer, inflammation and ageing.'], ['The metabolism of neuroexcitotoxic glutamate is lowered in many neurodegenerative disorders.'], ['This paper reviews the characteristics of sleep disorders found in people at a greater risk of dementia: the elderly adult, patients with mild cognitive impairment (MCI) and those with neurodegenerative diseases.', "In fact, RBDs are suggestive of Lewy body dementia (LBD) and are predictive for neurodegeneration in Parkinson's disease."], ['Ketogenic diets (KDs), successfully used in the therapy of paediatric epilepsy for nearly a century, have recently shown beneficial effects also in cancer, obesity, diabetes, GLUT 1 deficiencies, hypoxia-ischemia, traumatic brain injuries, and neurodegeneration.', "Encouraging results obtained in patients affected by age-related neurodegenerative diseases have prompted new interest on KDs' effect on the aging brain, also considering the poor efficacy of therapies currently used.", 'Thus, further studies are needed to design KDs specifically indicated for single neurodegenerative diseases, and to ameliorate the balance between beneficial and adverse effects in aged subjects.'], ["OBJECTIVES: Parkinson's disease is one of the most common neurodegenerative diseases in the elderly population."], ['Cockayne syndrome (CS) is a human premature aging disorder associated with severe developmental deficiencies and neurodegeneration, and phenotypically it resembles some mitochondrial DNA (mtDNA) diseases.'], ['Deficiency in docosahexaenoic acid (DHA) is associated with impaired visual and neurological development, cognitive decline, macular degeneration, and other neurodegenerative diseases.', 'These in turn support homeostasis during brain and retinal aging, counteract inflammatory signaling, and downregulate events that support the initiation and progression of neurodegenerative disease.'], ['OBJECTIVE: Inflammation plays an important role in many chronic degenerative diseases associated with aging, and social, economic, and behavioral factors that contribute to inflammation may lead to differential burdens of morbidity and mortality in later life.'], ['As in the case of aging, many degenerative disorders also result from progressive mitochondrial deterioration and cellular damage accumulation.', 'Therefore, preventing damage accumulation may delay aging and help to prevent degenerative disorders, especially those associated with mitochondrial dysfunction.'], ['Although the central nervous system plays a direct role in regulating bone mass, primarily through the actions of the hypothalamus, there is little work investigating the possible role of neurodegeneration in bone loss.', 'In this cross-sectional study, we examined the association between bone mineral density (BMD) and neuroimaging markers of neurodegeneration (i.e., global and regional measures of brain volume) in early AD and non-demented aging.', 'These results demonstrate that lower BMD is associated with lower hypothalamic volume in early AD, suggesting that central mechanisms of bone remodeling may be disrupted by neurodegeneration.'], ["Alzheimer's disease (AD) is a devastating age-related neurodegenerative disease."], ["Alzheimer's disease (AD) is a progressive, neurodegenerative brain disease of the elderly characterized by memory loss, cognition, and behavioral abnormalities."], ['The formation of amyloid, a cross-beta-sheet fibrillar aggregate, is associated with a variety of aging-associated degenerative diseases.'], ['This study establishes a reference for future studies of age-related brain changes and neurodegenerative diseases in the elderly.'], ['Tempol was effective in some models of neurodegeneration.'], ['The modified approach (MAPER, multi-atlas propagation with enhanced registration) extends the applicability of multi-atlas based automatic whole-brain segmentation to subjects with ventriculomegaly, as seen in normal aging as well as in numerous neurodegenerative diseases.'], ['BACKGROUND: Advanced glycation endproducts (AGEs), final reaction products of protein with sugars, are known to contribute to various disorders, including diabetes, aspects of aging, and neurodegenerative diseases.'], ['There is evidence of an association between increased bone lead levels and renal disease, degenerative diseases like cataract, and suggestive but not causal association with blood pressure and hypertension.'], ['Research into the pathologic mechanisms of neurodegenerative diseases has revealed that CREB binding protein (CBP) plays an important role in cognitive dysfunction.'], ["Alzheimer's disease (AD), a neurodegenerative disorder, is the most common form of dementia in the elderly individuals.", 'Among the pathogenic mechanisms in AD, chronic systemic inflammation is described and characterized by massive production of proinflammatory cytokines by peripheral blood mononuclear cells (PBMCs), which may contribute to an altered immune response and exacerbation of neurodegeneration.'], ['BACKGROUND: The accumulation and aggregation of alpha-synuclein in nerve cells and glia are characteristic features of a number of neurodegenerative diseases termed synucleinopathies.'], ['Aging is accompanied by a decline in the healthy function of multiple organ systems, leading to increased incidence and mortality from diseases such as type II diabetes mellitus, neurodegenerative diseases, cancer, and cardiovascular disease.'], ['In the future, multi-tracer imaging or development of agents enabling imaging of other protein aggregations in neurodegenerative diseases could further help in the early and differential diagnostics and evaluation of novel treatments.'], ['For decades, it has been acknowledged that oxidative stress due to free radical species contributes to the pathophysiology of aging and neurodegenerative diseases.'], ['In others, the neurodegeneration is large enough to cause neurological disorders (e.g.'], ['Ageing affects many cellular processes that predispose to neurodegeneration, and age-related changes in cellular function predispose to the pathogenesis of PD.', "These may be due to age-related decline in dopaminergic activity, incidental Lewy body disease, degenerative pathologies (early PD and Alzheimer's disease) or vascular pathology."], ["A survey of research activity on nanoparticles (NPs) based on polymeric devices that could cross the blood-brain barrier (BBB) is given along with the presentation of our own data on the development of NPs of n-butyl-2-cyanoacrylate (BCA) for brain delivery to aid the early diagnosis of Alzheimer's disease (AD), a neurodegenerative disorder of the elderly people, the most prevalent form of dementia."], ['These effects are pertinent to the roles of autophagy in normal human physiology, including the early neonatal period and ageing, as well as a variety of diseases, including cancer, neurodegenerative conditions and infectious diseases.'], ['Chronic degenerative diseases, such as muscular dystrophies, are characterized by repeated cycles of segmental necrosis and regeneration involving scattered myofibers.'], ['Axonal degeneration is a common pathologic feature in peripheral neuropathy, neurodegenerative disease, and normal aging.'], ['Such biomarkers of ageing should help on the one hand to characterise this biological age and, as age is a major risk factor in many degenerative diseases, could be subsequently used on the other hand to identify individuals at high risk of developing age-associated diseases or disabilities.'], ["Parkinson's disease (PD) is a chronic neurodegenerative disorder that has a major impact on health and longevity in Eastern countries."], ['At the level of the individual organism ageing is associated with a progressive deterioration of health and quality of life, sharing common features such as: alopecia and grey hair, loss of audition, macular degeneration, neurodegeneration, cardiovascular diseases, osteoporosis, cataract formation, type-2 diabetes, lipodystrophies; a generally increased susceptibility to infection, autoimmune disorders and diseases such as cancer; and an impaired ability to cope with stress.'], ['Depositions of proteins in form of amyloid and non-amyloid plaques are common pathogenic signs of more than 20 degenerative diseases affecting the central nervous system or a variety of peripheral tissues.', 'The detection of specific biomarkers would be useful to develop a differential diagnostic, distinguishing not only different neurodegenerative diseases but also the disease from the non-pathological effects of aging.'], ['Recent advances have been made in our scientific understanding of how berries promote human health and prevent chronic illnesses such as some cancers, heart disease, and neurodegenerative diseases.'], ['Decreased expression and/or activity of antioxidant proteins leads to oxidative stress, accelerated aging, and neurodegeneration.', "Recent findings emphasize a relationship between elevated Hcy levels and neurodegeneration, which can be observed in Alzheimer's and Parkinson's diseases.", 'Recent studies have shown that the heat-shock response (HSR) contributes to cytoprotection in a number of human diseases including inflammation, cancer, aging, and neurodegenerative disorders.', 'L: -Acetylcarnitine (LAC) is proposed as a therapeutic agent for several neurodegenerative disorders and also current evidence suggests that the compound may play a critical role in the modulation of cellular stress response in health and disease conditions.', 'Here, we review the emerging salient concepts highlighting the pathways of neurodegeneration and the role of LAC in modulating the redox-dependent mechanisms responsible for the upregulation of vitagenes in brain that leads to the enhancement of stress tolerance in brain.'], ['These mutations keep the animals functional and pathology-free to later ages, and they can protect against specific ageing-related diseases, including neurodegenerative disease and cancer.'], ['As these patients are at higher risk of conversion to dementia, we propose that an increased serum IL-1beta level is a stage marker of the ongoing brain neurodegeneration in the continuum between normal ageing and AD.'], ['Mitochondrial DNA provides information on the origin of humans, and plays a substantial role in forensics, degenerative diseases, cancers, and aging process.'], ['Future studies in which the effects of specific manipulations of BAT levels and thermogenic activity on disease processes in animal models (diabetes, cardiovascular disease, cancers, neurodegenerative diseases) are determined will establish if and how BAT affects the development and progression of age-related diseases.'], ["Diseases of aging such as Alzheimer's disease, other neurodegenerative diseases, arteriosclerosis, diabetes mellitus, and others may all be contributed to by excess copper and iron."], ['Accordingly, mitochondrial DNA damage was shown to be associated with ageing as well as with numerous human diseases including neurodegenerative disorders and cancer.'], ['Although we know little of the diseases of aging under premodern conditions, in captivity, chimpanzees present a lower incidence of cancer, ischemic heart disease, and neurodegeneration than current human populations.'], ['One is malnutrition in North Korea and China and the other is chronic degenerative disease in Japan, South Korea and China.'], ['OBJECT: The aim of the study was to assess postprocedural neurological deterioration and outcome in patients older than 70 years of age in whom treatment was managed in an interdisciplinary context.', 'Postprocedural neurological deterioration occurred in 30 patients (46.9%), related to ischemia in 19 (29.7%), rebleeding in 1 (1.6%), and hydrocephalus in 10 (15.6%).'], ['Chronic-degenerative diseases are the illnesses that most affect the elderly population, directly related to the growing demand for Enteral Nutrition Therapy.'], ['Previous studies show that free radicals and reactive oxygen species play major roles in the etiology and/or progression of neurodegenerative diseases and aging.'], ["Parkinson's disease is a progressive, neurodegenerative disorder affecting millions of people worldwide."], ["Alzheimer's disease (AD) is a insidious and progressive neurodegenerative disorder of the elderly."], ['Combined expression of the Hq mouse mutation and the tau transgene in the Tau/Hq double mutant mice led to an increase in tau pathology and apoptotic neurodegeneration when compared to single expression of the two mutations.', 'Neurodegeneration was most prominent in the dentate gyrus and was significantly increased in the cerebellum leading to aggravated motor deficits.', 'Functional activity measurements of the mitochondrial respiratory chain (MRC) in the Tau/Hq mice revealed early decreased activities of multiple MRC complexes and depleted ATP levels which preceded neurodegeneration and elevated oxidative stress markers.', 'These results suggest an age-dependent mutual reinforcement of the tau pathology and mitochondrial dysfunction in vivo, which may contribute to neurodegeneration in patients suffering from AD and other age-related tauopathies.'], ['A background of degenerative disease and occult presentation in the elderly may delay diagnosis.'], ['On the other hand, apo D expression has been correlated, in some brain regions, with normal ageing and neurodegenerative diseases.'], ['The human aging process is often accompanied by significant increases in degenerative spine disease.'], ['Recent large clinical trials demonstrating deleterious effects of postmenopausal hormone replacement therapy have raised interest in the use of food products and extracts containing phytoestrogens as potential safe alternatives for menopausal symptoms, age-related cognitive decline and neurodegenerative diseases.', 'Numerous in vitro and in vivo studies show potential neuroprotective properties of phytoestrogens on the brain in conditions ranging from aging to neurodegenerative disease and cerebral ischemia.'], ['Initially, we illustrate well known modifications of cholinergic transmission during physiological (normal aging) and pathological neurodegeneration.'], ['The high frequency of mitochondrial DNA (mtDNA) mutations in somatic mammalian cells, which is more than two orders of magnitude higher than the mutation frequency of nuclear DNA (nDNA), significantly correlates with development of a variety of mitochondrial diseases (neurodegenerative diseases, cardiomyopathies, type II diabetes mellitus, cancer, etc.).'], ['However, it still remains controversial whether depressive symptoms represent a risk factor for AD, whether they are an early symptom of neurodegeneration, or whether they are a reaction to early cognitive deficits.'], ['We present the case of an elderly woman with severe degenerative joint disease of the shoulder and severe COPD in whom spinal cord stimulation was used to provide pain control.'], ['Using an original chronic intermittent restraint stress (CIRS) protocol, we examined the effect of stress on hippocampal neurogenesis and neurodegeneration by immunohistochemical analysis.', 'After short-term CIRS, neurodegeneration in Tg mice was significantly increased in the hippocampus with an earlier onset and progression than in the non-stressed Tg mice.', 'Moreover, after long-term CIRS, transitional neurodegeneration appeared to proceed along the neuronal circuit involved in cognitive function in stressed Tg mice.', 'We conclude from these results that diverse responses against stressful experiences among genetically predisposed individuals could lead to cognitive dysfunction through retardation of neuronal maturation and neurodegeneration.'], ['Fifty-four patients were female performing floor activities for more than 28 times/week or more than 2 hours/week for longer than 10 years significantly increased the risk of degenerative spinal diseases by more than 15 times when being compared to the control.', 'The most predictable activities related to the degenerative spinal diseases were occupational, cooking, and latrine use.', 'CONCLUSION: Floor activities increased the risk of symptomatic degenerative spinal diseases in the Thai population.'], ['The chapter continues with a discussion of some of the diseases caused by defective DNA, especially the trinucleotide repeat expansion diseases (TREDs) and ends with a short account of the development of molecular approaches to prion diseases, myasthenia gravis, and the neurodegenerative diseases of old age.'], ['3D finite element models of human lumbar functional spinal units (FSU) were used for numerical analysis of weightbath hydrotraction therapy (WHT) applied for treating degenerative diseases of the lumbar spine.'], ['These findings, along with studies that show a risk for neurodegenerative disease in those with low testosterone, suggest that sex hormone status may be important for neuroprotection in aging but not modulation of normal day-to-day cognitive function.'], ['CLU has been functionally implicated in several physiological processes as well as in many pathological conditions including ageing, diabetes, atherosclerosis, degenerative diseases, and tumorigenesis.'], ['Friedreich ataxia (FRDA) is a relentlessly progressive neurodegenerative disorder caused by GAA.TTC repeat expansion in the first intron of the FXN gene.'], ["Parkinson's disease is the second most common neurodegenerative disorder, after Alzheimer's disease."], ['We will discuss the evidence that insulin/IGF-1 signaling can enhance the NF-kappaB signaling and subsequently potentiate the aging process and aggravate age-related degenerative diseases.'], ['PURPOSE: Lumbar spinal stenosis (LSS), a degenerative disease encountered in adults > 65 years, is a leading cause of back and lower extremity pain, weakness, impaired sensation and balance.'], ['A wealth of evidence underscores the tight link between oxidative stress, neurodegeneration and aging.', "Here we discuss the implications that oxidation of K(+) channels by ROS might have for the mammalian brain during normal aging, as well as in neurodegenerative diseases such as Alzheimer's and Parkinson's."], ["BACKGROUND: Parkinson's disease (PD) is a common neurodegenerative disorder in the elderly that may lead to both motor and non-motor symptoms with consequent severe impairment of quality of life."], ['As patients progress to dementia, clinical decline and neurodegeneration accelerate and proceed independently of amyloid accumulation.'], ['Arguments are advanced that vitamin D appears to play a major positive role in biogerontology by reducing susceptibility in the elderly to chronic degenerative diseases.'], ['Unexpectedly, AF turned to be associated to AD more often than to VAD, becoming a possible risk factor for this neurodegenerative disease.'], ['These latest findings suggest that genes controlling quiescence are conserved from yeast to humans, and support the use of S. pombe as a model to enhance our understanding of the causes of aging, diabetes, obesity and neurodegeneration.'], ['The onset of age-related neurodegenerative diseases superimposed on a declining nervous system could enhance the motor and cognitive behavioral deficits that normally occur in senescence.', 'Recent studies suggest that consumption of diets rich in antioxidants and anti-inflammatory components such as those found in fruits, nuts, vegetables, and spices, or even reduced caloric intake, may lower age-related cognitive declines and the risk of developing neurodegenerative disease.'], ["Decay of mitochondria and oxidative stress are associated with normal aging, but many neurodegenerative diseases, and particularly Alzheimer's disease (AD), are characterized by a significant increase in the intensity of these traits."], ['Furthermore, this aging-associated, progressive disorder is associated with neuronal loss and postmortem changes that occur in traditional neurodegenerative disorders.'], ["BACKGROUND: Parkinson's disease (PD) is a common neurodegenerative disorder in older people, and half of the world's older population lives in Asia."], ['The success of future neurodegenerative disease (ND) therapies depends partly on accurate antemortem diagnoses.', 'Relatively few prior studies have been performed on large, multicenter-derived datasets to test the accuracy of final clinical ND diagnoses in relation to definitive neuropathological findings.', 'Among subjects meeting final inclusion criteria (N = 2,861 for NACC Registry data), the strength of the associations between clinical diagnoses and subsequent ND diagnoses was only moderate.'], ['Autophagy plays roles in aging, development, neurodegeneration, cancer and immunity.'], ['In fact, cholesterol metabolism and catabolism are affected in this neurodegenerative disorder.'], ['Corticobasal degeneration (CBD) is a rare neurodegenerative disease affecting adults, being characterized clinically by a combination of extrapyramidal signs and focal cortical syndromes.', 'These findings further strengthen the idea that in AD, neurodegeneration with tau and Abeta deposits may begin in the fronto-parietal neocortical areas, which are often preferentially affected in CBD, earlier than, or as early as the medial temporal lobe, and that extrapyramidal signs, such as rigidity and tremor, can occur in the absence of neuronal loss in the basal ganglia and substantia nigra.'], ['The pandemic of chronic degenerative diseases associated with aging demographics mandates development of effective approaches for tissue repair.'], ['Such interventions could potentially treat multiple degenerative brain disorders by mitigating the effects of aging and associated changes in iron, cholesterol, and free radicals on oligodendrocytes and their myelin.'], ['Despite this progress, neurodegenerative diseases that affect higher order thinking and memory continue to increase in prevalence as they take a devastating toll on human productivity in the later years.'], ['However, the contribution of hypoxia and hypoxia-mediated pathways to neurodegeneration remains unclear.'], ["The coalition's purpose is to transform the drug development paradigm for neurodegenerative diseases and serve as a model for other major diseases."], ["Alzheimer's disease (AD) is an irreversible progressive neurodegenerative disease, leading to severe incapacity and death."], ['Brain inflammation is involved in the pathogenesis of neurodegenerative diseases.'], ["BACKGROUND: Brain volume progressively decreases with an increase in atrophy, and the brain becomes more susceptible to degenerative brain diseases such as Alzheimer's disease."], ["OBJECTIVE: Alzheimer's disease (AD) is a neurodegenerative disorder that is the most common cause of dementia in the elderly and is frequently accompanied by emotional disorder, including agitation."], ['OBJECTIVES: To delineate the influences of the Mediterranean diet (MD) on human mortality and age-related morbid conditions, principally the metabolic syndrome, hypertension, cardiovascular disease, excess body weight, cancer, poor bone mineralization and rheumatoid arthritis, and neurodegenerative disorders.'], ["BACKGROUND: Understanding the aetiologies of neurodegenerative diseases such as Alzheimer's disease (AD), Pick's disease (PiD), Progressive Supranuclear Palsy (PSP) and Frontotemporal dementia (FTD) is often hampered by the considerable clinical and molecular overlap between these diseases and normal ageing.", 'METHODOLOGY/PRINCIPAL FINDINGS: We have constructed genome wide expression profiles from snap frozen post-mortem tissue from the medial temporal lobe of patients with four neurodegenerative disorders (5 AD, 5 PSP, 5 PiD and 5 FTD patients) and 5 control subjects.', 'Furthermore, from this dataset we extracted a disease specific set of genes and identified two aging related transcription factors (FOXO1A and FOXO3A) as possible drug targets related to neurodegenerative disease.'], ['In human medicine, mild zinc deficiencies are currently thought to cause chronic metabolic derangement leading to or exacerbating immune deficiency, gastrointestinal problems, endocrine disorders, neurologic dysfunction, cancer, accelerated aging, degenerative disease, and more.'], ['Atherogenic dyslipidaemia associated with a pro-inflammatory pro-thrombotic state in metabolic syndrome and related risk of fatty liver, arthritis, neurodegenerative disorders and certain types of cancers are ideal therapeutic targets for bioactive phytochemicals which can combat oxidative stress induced damage at a sub-cellular level.'], ['We review data pertinent to the mitochondrial biogenesis field, and discuss implications for brain aging and neurodegenerative disease research efforts.'], ['It is quite apparent that the incidence of neurodegenerative diseases in both men and women increases in a logarithmic fashion with age and begins to rise much more rapidly after the age of 60.'], ['The identification of degenerating microglia has given rise to a novel theory of AD pathogenesis, the microglial dysfunction hypothesis, which views the loss of microglial neuroprotection as a central event in neurodegenerative disease development.'], ['With increasing age, however, we found that the overexpression of human wild-type PS1 progressively decreased NMDA-R-mediated synaptic transmission and LTP, without neurodegeneration.'], ["Imaging of patients with Alzheimer's disease has allowed quantitative exploration of the natural history of amyloid deposition and its relationship to neurodegeneration."], ["The focus is on the morphological and biochemical changes that occur in normal aging, and the early neuropathological changes of neurodegenerative diseases, especially Alzheimer's disease (AD)."], ["Alzheimer's disease (AD) is the most prevalent form of neurodegeneration; however, therapies to prevent or treat AD are inadequate."], ['While numerous pathogenic mutations in both mtDNA and nDNA mitochondrial genes have been identified in the past 21 years, the causal role of mitochondrial dysfunction in the common metabolic and degenerative diseases, cancer, and aging is still debated.'], ['Dysfunction of complex I is implicated in many human neurodegenerative diseases.'], ['An effective therapy that successfully decelerates or prevents the progressive neurodegeneration does not exist.'], ['H(2)S releasing drugs may have therapeutic potential in neurodegenerative disorders of aging such as Alzheimer disease and Parkinson disease.'], ['Maintenance of genome integrity is essential for homeostasis and survival as impaired DNA damage response (DDR) may predispose to grave pathologies such as neurodegenerative and immunodeficiency syndromes, cancer and premature aging.'], ['Obesity and the metabolic syndrome (insulin resistance, visceral adiposity and dyslipidemia) wreak havoc on cells throughout the body thereby promoting cardiovascular and kidney disease, and degenerative diseases of the brain and body.'], ['We propose that modulation of p38MAPK activity may provide new avenues for treating certain age-related degenerative diseases.'], ['Our findings suggest that reduction in NEP and IDE activity is not the primary cause of beta-amyloid accumulation in AD, but rather a late-stage phenomenon secondary to neurodegeneration.'], ['Idiopathic RBD (iRBD) has a known association with neurodegenerative diseases such as synucleinopathies.'], ['Fragile X-associated tremor/ataxia syndrome (FXTAS) is a neurodegenerative disorder caused by a CGG repeat expansion in the premutation range (55-200) in the fragile X mental retardation 1 gene.'], ['Methods to potentiate the proliferation of new neuronal or glial cells within the central nervous system from resident NSCs could have therapeutic potential following an insult, such as stroke, or to replace lost cells as a result of a neurodegenerative disease.'], ['Injuries in the craniocervical region corresponded to 43 (19.8%) of the cases; injuries in the cervical subaxial region corresponded to 174 (80.2%) of the cases and were associated with worse neurological lesions.', 'During the hospitalization period, 4 patients presenting as Grade A on the American Spinal Injury Association (ASIA) Scale evolved to Grade C, 1 patient presenting as ASIA Grade A evolved to Grade B, and 2 patients evolved to Grade E. Two patients who had been admitted without neurological lesions evolved to ASIA Grade C (1 patient postsurgery and 1 patient post-traction).'], ['Neurogenic intermittent claudication, caused by lumbar spinal stenosis (LSS), usually occurs after the age of 50 and is one of the most common degenerative spinal diseases in the elderly.'], ['Chronic para-inflammation contributes to the initiation and progression of many human diseases including obesity, type 2 diabetes, atherosclerosis, and age-related neurodegenerative diseases.'], ['p62 is an integral component of inclusions in brains of various neurodegenerative disorders, including Alzheimer disease (AD) neurofibrillary tangles (NFTs) and Lewy bodies in Parkinson disease.'], ['Research in the last decade has indicated not only that autophagy provides cells with oxidizable substrate when nutrients become scarce but also that it can provide protection against aging and a number of pathologies such as cancer, neurodegeneration, cardiac disease, diabetes, and infections.'], ['The presence of misfolding-prone D187N gelsolin appears to exacerbate the age-associated decline in cellular protein homeostasis (proteostasis), reflected by the intracellular deposition of numerous proteins, a characteristic of the most common degenerative muscle disease of aging humans, sporadic inclusion body myositis.'], ['These include infections, degenerative disorders, brain injury and cerebrovascular lesions, principally involving the frontal lobes and basal ganglia.'], ['These findings now provide a novel basis for understanding the ability of exercise to delay the onset and rate of decline in neurodegenerative conditions not typically associated with the hippocampus and suggest that the GH-dependent activation of endogenous NSCs may be effective in reversing or preventing age-related neurodegeneration in humans.'], ["An important corollary to this latter concept is that a promising therapeutic approach against Parkinson's and other neurodegenerative diseases is to prevent alpha-synuclein accumulation."], ['Stress- and mutation-induced protein damages in the cell, causing degenerative diseases and aging, may thus be effectively counteracted by a powerful network of molecular chaperones and of chaperone-related proteases.'], ['Deficiency in docosahexaenoic acid (DHA) is associated with impaired visual and neurological postnatal development, cognitive decline, macular degeneration, and other neurodegenerative diseases.', 'Overall, these results support the concept that NPD1 promotes brain and retina cell survival via the induction of antiapoptotic and neuroprotective gene-expression programs that suppress Abeta42-induced neurotoxicity and other forms of cell injury, which in turn fosters homeostasis during development in aging, as well as during the initiation and progression of neurodegenerative diseases.'], ['One explanation could be that vascular complications of diabetes result in neurodegeneration.', 'Furthermore, postmortem analyses of brains from patients with AD revealed a markedly downregulated expression of insulin receptor (IR), IGF-1 receptor (IGF-1R), insulin receptor substrate (IRS)-1 and IRS-2, and these changes progress with severity of neurodegeneration.', 'These findings raise the question, whether this phenomenon is cause or consequence of neurodegeneration.'], ["Alzheimer's disease (AD) is a late-onset progressive neurodegenerative disorder which results in the irreversible loss of cortical neurons, particularly in the associative neocortex and hippocampus."], ["The role of microglial cells in the pathogenesis of Alzheimer's disease (AD) neurodegeneration is unknown."], ['Their accumulation in the genome is linked to aging and degenerative diseases.'], ['Blindness incidence increased with advancing age, such as cataract and glaucoma, which are by far the commonest causes of blindness in our sample and in all age groups, glaucomatous neurodegeneration can be treated with developed NAC autoinduction prodrug eye drops equipped with corneal absorption promoters.'], ['The motor neuron diseases (MNDs) are a group of related neurodegenerative diseases that cause the relative selective progressive death of motor neurons.', 'Organophosphate-induced delayed neuropathy (OPIDN) is a neurodegenerative disorder characterized by ataxia and progression to paralysis, with a concomitant distal axonal degeneration and secondary demyelination of central and peripheral axons.'], ['In fact, studies in animal models have proven that the transplantation of RPE cells can delay the course of photoreceptor degenerative diseases.'], ['The Dietary Reference Intakes (DRIs) were established to be an indicator of adequacy of dietary nutrients as well as providing levels for adequacy in reducing risk of chronic diseases such as neurodegenerative diseases, cardiovascular diseases, cancers, diabetes mellitus, etc.', 'One particular nutrient that is increasingly discussed as a potential candidate for the generation of a DRI is the omega-3 (n-3) fatty acid docosahexaenoic acid (DHA) due to its potential benefits in reducing risk for cardiovascular disease, role in resolution of inflammation, its importance in cognitive function in infants and inhibiting the progression of neurodegenerative diseases in the elderly.'], ['The RAGE binds multiple ligand families linked to hyperglycemia, aging, inflammation, neurodegeneration, and cancer.'], ['heart failure, coronary heart disease, asthma/COPD, stroke, diabetes mellitus Type 2, degenerative diseases of the joints, depression and others.'], ['Parkinson disease (PD) is an age-related neurodegenerative disorder that affects as many as 1-2% of persons aged 60 years and older.'], ["In a recent issue of NeuroImage, we presented evidence that biased global mean (GM) normalization of brain PET data can generate the appearance of subcortical foci with relative hypermetabolism in patients with Parkinson's disease (PD), and other degenerative disorders."], ['OBJECTIVE: To compare the tensile biomechanical properties of age-matched adult human knee articular cartilage exhibiting distinct stages of degenerative or osteoarthritic deterioration and to determine the relationships between tensile properties and biochemical and structural properties hypothesized to underlie functional biomechanical deterioration.'], ['Osteoporosis and sarcopenia are degenerative diseases frequently associated with aging.'], ["In 'stressed' astroglia, HO-1 hyperactivity promotes mitochondrial sequestration of non-transferrin iron and macroautophagy and may thereby contribute to the pathological iron deposition and bioenergetic failure amply documented in Alzheimer disease, Parkinson disease and other aging-related neurodegenerative disorders."], ['Modulation of endogenous cellular defense mechanisms via the stress response signaling represents an innovative approach to therapeutic intervention in diseases causing chronic damage, such as neurodegeneration and cancer.', 'In this review we discuss the most current and up-to-date understanding of the possible signaling mechanisms by which acetylcarnitine by activating vitagenes can differentially modulate signal transduction cascades inducing apoptosis/cell death in abnormal cancer cells but at the same time enhancing defensive enzymes to protect against carcinogenesis and neurodegeneration in normal cells.'], ['Altogether, our results suggest that functional dynamics of thalamocortical networks differentiate individuals at high risk of developing AD from healthy elderly subjects, supporting the hypothesis that neurodegeneration mechanisms are active years before the patient is clinically diagnosed with dementia.'], ['The biomarkers measured in this assay have been associated with increased risk of accelerated ageing, cancer and neurodegenerative diseases.'], ["BACKGROUND: The conversion of soluble peptides and proteins into polymeric amyloid structures is a hallmark of many age-related degenerative disorders, including Alzheimer's disease, type II diabetes and a variety of systemic amyloidoses."], ["Parkinson's disease is a common neurodegenerative disease in the elderly."], ["In this study, we focused on brain aging and on mechanism involved in neurodegeneration such as events occurring in Alzheimer's disease (AD)."], ['This easily obtainable multipotent cell population has raised expectations for their potential use in cell therapy of neurodegeneration.'], ['Accordingly, sporadic prion and other neurodegenerative diseases, as well as various aging processes, might also be caused by oxidative stress leading to Met oxidation.'], ['They have been as important potential targets for treatment of aging, degenerative diseases, diabetes and obesity.'], ['AGEs act as mediators of neurodegeneration, induce irreversible changes in the extracellular matrix, vascular dysfunction and pro-inflammatory signalling.'], ['The constant ageing of the population has resulted in an increase in chronic conditions such as osteoporosis and neurodegenerative diseases as well as in patient comorbidity.'], ["Amyloid-beta peptide species accumulating in the brain of patients with Alzheimer's disease are assumed to have a neurotoxic action and hence to be key actors in the physiopathology of this neurodegenerative disease."], ['While the reason for iron accumulation is unknown, iron localization correlates with the production of reactive oxygen species in those areas of the brain that are prone to neurodegeneration.'], ['In vivo quantification of these changes might be of use as a novel neuroimaging marker of cholinergic neurodegeneration in AD.'], ['The development of drugs for the treatment of AD that breaks the vicious cycles of oxidative stress and neurodegeneration offer new opportunities.'], ['Mutations in genes that control these pathways are associated with increased genomic instability, neurodegeneration, immunodeficiency, premature aging and tumour predisposition.'], ['Degenerative disease was the most prevalent (77%) etiology.'], ['Alterations in the blood brain barrier and brain vasculature may be involved in neurodegeneration and neuroinflammation.'], ['However, the very same pathophysiological processes comprise the "unbuilding" blocks of aging and insulin-resistance diseases including, neurodegeneration, diabetes mellitus (DM), and non-alcoholic steatohepatitis (NASH).'], ['Moreover, an active lifestyle might prevent or delay loss of cognitive function with aging or neurodegenerative disease.'], ['This process occurs in the brain during aging and neurodegeneration and coincides with impairment of the ubiquitin proteasome system.'], ['The differential sensitivity toward oxidative stress might explain the difference between the range and severity of symptoms in CS and the mild manifestations in UV(s)S patients that are limited to skin photosensitivity without precocious aging or neurodegeneration.'], ['These TDP-43 negative, UBQ-ir inclusions appear to be more related to ageing than neurodegeneration, and are without apparent diagnostic significance.'], ["A growing body of evidence indicates that autophagy is associated with heart disease, cancer and a number of neurodegenerative disorders, such as Alzheimer's, Parkinson's and Huntington's diseases."], ['Mitochondrial DNA (mtDNA) depletion and the resulting mitochondrial malfunction have been implicated in cancer, neurodegeneration, diabetes, aging, and many other human diseases.'], ['Heat shock response contributes to establish a cytoprotective state in a wide variety of human diseases, including inflammation, cancer, aging and neurodegenerative disorders.', 'In the present review we discuss the importance of vitagenes in the cellular stress response and analyse, from a pharmacological point of view, the potential use of dietary antioxidants in the treatment of neurodegenerative disorders in humans.'], ['While less lethal than mutations in the genome and not inheritable, such sublethal damage to cells might be associated with underlying mechanisms of degeneration, especially age-associated neurodegeneration that is commonly found in the elderly population.', 'Indeed, oxidative RNA damage has been described recently in most of the common neurodegenerative disorders including Alzheimer disease, Parkinson disease, dementia with Lewy bodies and amyotrophic lateral sclerosis.', 'Of particular interest, the accumulating evidence obtained from studies on either human samples or experimental models coincidentally suggests that oxidative RNA damage is a feature in vulnerable neurons at early-stage of these neurodegenerative disorders, indicating that RNA oxidation actively contributes to the onset or the development of the disorders.', 'Further investigations aimed at understanding of the processing mechanisms related to oxidative RNA damage and its consequences may provide significant insights into the pathogenesis of neurodegenerative disorders and lead to better therapeutic strategies.'], ['The pathological changes in osteoarthritis--a degenerative joint disease prevalent among older people--start at the molecular scale and spread to the higher levels of the architecture of articular cartilage to cause progressive and irreversible structural and functional damage.'], ['Uncovering the molecular mechanisms is also of great interest to a better understanding of SSC aging and for developing novel therapeutic strategies for degenerative diseases in view of the recent work demonstrating the pluripotent potential of the SSC.'], ['Several experimental models based on genetically modified mice have been used in order to address the role of IL-1 in neurodegeneration and neuroprotection.'], ['The presence of 1 degenerative lesion increased the odds of having the other degenerative lesion by between 1.6 and 2.0 in all patient groups.'], ['A decline in Zn status with ageing may contribute to the development of frailty, including impaired immune function, and increased incidence of age-related degenerative diseases.'], ["Oxidative stress, which plays a critical role in the pathogenesis of neurodegenerative diseases such as Alzheimer's disease (AD), is intimately linked to aging - the best established risk factor for AD.", 'In summary, this work presents a human cell model prepared to mimic the effect of oxidative stress in neurons that might be useful in clarifying the mechanism involved in free radical-induced neurodegeneration.'], ["Alterations in these fine-tuned mechanisms underlie the pathogenesis of severe human diseases including, among others, common neurodegenerative disorders such as Alzheimer's or Parkinson's disease."], ['Sensitivities of the full domain measures were universally high, but information about their specificity against psychiatric and non-progressive neurological conditions and predictive validity is lacking.'], ['Recent studies have highlighted the fact that autophagy plays crucial roles in many aspects of human health including cancer development, neurodegenerative disease, diabetes, and aging.'], ['During clinical practice, degenerative diseases in some patients appear after exposure to a severe psychological stress.', 'This review provides the basis for creating interventions and educational programs during midlife in order to prevent dementia or other neurodegenerative diseases or to halt the progress of neurodegeneration in the early stages.'], ["During the subsequent 20 years there has been an exponential growth in 'mitochondrial medicine', with clinical, biochemical and genetic characterizations of a wide range of mitochondrial diseases and evidence implicating mitochondria in a host of many other clinical conditions including ageing, neurodegenerative illness and cancer."], ["Degenerative neurologic disorders that cause dementia, such as Alzheimer's disease and Parkinson's disease, exacerbate age-related changes in sleep, as do many common comorbid medical and psychiatric conditions."], ['This growth has established DNA repair as a central factor for maintaining genomic stability and preventing cancer, neurodegenerative disease and aging.'], ['Tissue damage caused by oxidative stress has been implicated in aging, carcinogenesis, atherosclerosis and neurodegeneration.', 'In xeroderma pigmentosum (XP) and Cockayne syndrome (CS), oxidative stress is associated with promoted occurrence of skin cancers and progressive neurodegeneration, because decreased DNA repair and persistent DNA damage can result in augmented oxidative nucleotide damage.', 'Also, oxidative nucleotide damage with reduced expression of superoxide dismutases has been identified in the basal ganglia lesions, lending further weight involvement of oxidative stress in neurodegeneration in XPA patients.'], ['However, this phenotype does not explain the progressive neurodegeneration in CS patients.'], ['Recent studies have revealed SIRT1 protects neurons from axonal degeneration or neurodegeneration.'], ['Its mouse/human homologs, lipidosin/bubblegum, have been suggested to participate in X-linked adrenoleukodystrophy (X-ALD), an adreno/neurodegenerative disorder with accumulation of very long chain fatty acids (VLCFA) in tissues and plasma.'], ['Glutathione (GSH) plays an important role in a multitude of cellular processes, including cell differentiation, proliferation, and apoptosis, and as a result, disturbances in GSH homeostasis are implicated in the etiology and/or progression of a number of human diseases, including cancer, diseases of aging, cystic fibrosis, and cardiovascular, inflammatory, immune, metabolic, and neurodegenerative diseases.'], ['Calcific aortic stenosis is a frequent degenerative disease, which represents the most common indication for adult heart valve surgery, and carries substantial morbidity and mortality.'], ["The presence of deep sulci and 'collapsed gyri' (caused by the loss of tissue in patients with neurodegenerative diseases) complicates the tissue segmentation due to partial volume (PV) effects and limited resolution of MRI."], ['Oxidative stress is implicated in the pathogenesis of a variety of human diseases, including neurodegenerative disease, atherosclerosis and cancer, as well as progressive and even normal aging processes.'], ['The phenomenon of microbe-induced cancers raises a number of important biological questions, the solving of which may inform other fields, including aging and degenerative disorders.'], ['Moreover, haploinsufficiency of RelA rescues the early lethality and degenerative syndrome of Sirt6-deficient mice.'], ["Oxidative stress is a key feature during progression of chronic neurodegenerative conditions such as Alzheimer's disease."], ['In humans, this can lead to neurodegeneration and other protein conformational diseases.'], ["Parkinson's disease (PD) is the most prevalent human neurodegenerative movement disorder and is characterized by a selective and progressive loss of the dopaminergic neurons."], ['These genomic screens can be extended to discover genes/proteins that attenuate oxidative stress-induced damage, which is implicated in aging, neurodegenerative disorders, and other diseases.'], ["Alzheimer's disease (AD) is the most common form of neurodegenerative disease associated with dementia in the elderly."], ['Among these conditions are diabetes, neurodegenerative diseases, and cancer.'], ["Mutations of the mitochondrial genome have also been shown to accumulate with age and in common neurodegenerative diseases, such as Parkinson's disease.", 'This review presents recent data to show that the information gained from studying patients with mitochondrial disorders can help our understanding of the role of mitochondrial DNA mutations in brain aging and neurodegeneration.'], ["Alzheimer's disease (AD), the most common neurodegenerative disorder in the aged, is characterized by the cerebral deposition of fibrils formed by the amyloid beta-protein (Abeta), a 40-42 amino acid peptide."], ['Expression of a human gene encoding the PD-associated protein, alpha-synuclein, in C. elegans DA neurons results in dosage and age-dependent neurodegeneration.', 'The presence of GFP serves as a readily visualized marker for following DA neurodegeneration in these animals.', 'We initially demonstrated that alpha-synuclein-induced DA neurodegeneration could be rescued in these animals by torsinA, a protein with molecular chaperone activity.', 'We determined that five of seven genes tested represented significant candidate modulators of PD as they rescued alpha-synuclein-induced DA neurodegeneration.', 'We subsequently examined the yeast candidate genes in our C. elegans alpha-synuclein-induced neurodegeneration assay and successfully validated many of these targets.', 'Multiple stable transgenic lines producing the candidate protein in DA neurons are obtained and then independently crossed into the alpha-synuclein degenerative strain and assessed for neurodegeneration, at both the animal and individual neuron level, over the course of aging.'], ['PURPOSE OF REVIEW: To explore the role of iron physiology in the brain of healthy adults and review how increased brain iron deposition has been associated with common neurodegenerative diseases that affect the elderly.', 'SUMMARY: Pathologic and neurologic imaging coupled with experimentation have increased our understanding of the link between iron and neurodegeneration.', 'A potential implication is that disease-modifying therapies aimed at removing excess iron may one day be part of the armamentarium employed by clinicians to decrease the burden of neurodegenerative diseases in the elderly.'], ['Microglial activation is an important pathogenic component of neurodegenerative disease processes.', 'Imaging techniques may provide a minimally invasive tool to elucidate the complexities and dynamics of microglial function and dysfunction in aging and neurodegenerative diseases.'], ['BACKGROUND: Glaucoma is a chronic neurodegeneration of the optic nerve and one of the leading causes of vision loss in the world among the aging.'], ['The results of the study concluded that the extract of G. lucidum may effective to improve the function of mitochondria in aged rat brain, suggest its possible therapeutic application against ageing associated neurodegenerative diseases.'], ['Perturbed stem cell function contributes significantly to a variety of pathological conditions, eg impaired self-renewal capacity due to cellular senescence contributes to ageing, and degenerative diseases or impaired stem cell differentiation by oncogenic mutations contribute to cancer formation.'], ["Additional clinical research in this field is needed to confirm the existence and severity of such a possible cognitive impact, which may then need to be considered prior to initiating hormonal therapies in the elderly, as many patients may be in the prodromal phase or early stages of a neurodegenerative disorder, such as Alzheimer's disease, and this information may influence treatment decision-making and subsequent management."], ['The dietary essential PUFA docosahexaenoic acid [DHA; 22:6(n-3)] is a critical contributor to cell structure and function in the nervous system, and deficits in DHA abundance are associated with cognitive decline during aging and in neurodegenerative disease.'], ['None fulfilled the criteria for the neuropathologic diagnosis of Alzheimer disease or other neurodegenerative disease.'], ["The benefits of physical exercise on cognitive functioning have been reported in the literature, but the potential benefits to slow the eventual decline in executive functioning (EF) caused by neurodegeneration from Parkinson's Disease (PD) have rarely been studied."], ['The glucose analogue 2-deoxy-D-glucose (2-DG) restrains growth of normal and malignant cells, prolongs the lifespan of C. elegans, and is widely used as a glycolytic inhibitor to study metabolic activity with regard to cancer, neurodegeneration, calorie restriction, and aging.'], ['Because p53 family members play key roles in tumor suppression, development, aging and neurodegeneration, the context and manner by which these transcription factors regulate autophagy may have implications for a wide range of human diseases.'], ['These observations suggest that certain sequential systemic treatment with common sex steroids and their mixture might be effective in the treatment or prevention of degenerative CNS disorders.'], ["It then discusses higher-level hand motor function in age-related neurodegenerative diseases such as mild cognitive impairment, Alzheimer's disease and vascular dementia."], ["Alzheimer's disease (AD) is one of most common chronic neurodegenerative diseases in the elderly."], ['Interestingly, MSH2 deficiency prevented degenerative pathologies in the gastrointestinal tract of MSH2(-/-) Terc(-/-) mice concomitant with a rescue of proliferative defects.'], ["Also discussed are the intriguing phenotypic similarities between s-IBM muscle fibers and the brains of Alzheimer and Parkinson's diseases, the most common neurodegenerative diseases associated with aging."], ['To model Lewy body-associated neurodegeneration, we generated transfectant 3D5 of human neuronal-type in which expression of human wild-type alpha-syn is regulated by the tetracycline off (TetOff)-inducible mechanism.'], ['Epidemiological and clinical studies have linked environmental factors such as diet and lifestyle to cancer, diabetes, atherosclerosis, and neurodegenerative disorders.'], ['Oxidative stress has direct implications in the pathogenesis of age-related neurodegenerative diseases and careful scrutiny of oxidative stress in the CNS has therapeutic implications for future clinical trials.'], ['The aetiology of most neurodegenerative disorders is multifactorial and consists of an interaction between environmental factors and genetic predisposition.', 'Free radicals derived primarily from molecular oxygen have been implicated and considered as associated risk factors for a variety of human disorders including neurodegenerative diseases and aging.', 'The potential of environmental exposure to metals, air pollution and pesticides as well as diet as risk factors via the induction of oxidative stress for neurodegenerative diseases and aging is discussed.', "The role of genetic background is discussed on the light of the oxidative stress implication, focusing on both complex neurodegenerative diseases (Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis) and monogenic neurological disorders (Huntington's disease, Ataxia telangiectasia, Friedreich Ataxia and others).", 'Emphasis is given to role of the repair mechanisms of oxidative DNA damage in delaying aging and protecting against neurodegeneration.', 'The emerging interplay between environmental-induced oxidative stress and epigenetic modifications of critical genes for neurodegeneration is also discussed.'], ['The development of neurodegenerative diseases such as Alzheimer, Parkinson, and Huntington disease is strongly age-dependent.', 'Clioquinol is a metal chelator that has beneficial effects in several cellular and animal models of neurodegenerative diseases as well as on Alzheimer disease patients.', 'These results suggest that the surprising action of clioquinol on several age-dependent neurodegenerative diseases with distinct etiologies might result from a slowing down of the aging process through action of the drug on CLK-1.'], ['Gene expression changes in neuropsychiatric and neurodegenerative disorders, and gene responses to therapeutic drugs, provide new ways to identify central nervous system (CNS) targets for drug discovery.'], ["In the last decade, the budding yeast Saccharomyces cerevisiae has been used as a model system to study the mechanisms of the human aging process and of age-associated neurodegenerative disorders such as Parkinson's, Huntington's, Alzheimer's, and amyotrophic lateral sclerosis."], ['These results suggest a possible influence of APOE genotype on nitric oxide (NO) production that might enhance the effects of age-related specific factor(s) associated with neurodegenerative disorders.'], ['The twentieth century saw an increasing number of people living into old age, and consequently a higher prevalence of age-related chronic degenerative brain disorders.'], ["Alzheimer's disease and other neurodegenerative disorders of aging are characterized by clinical and pathological features that are relatively specific to humans."], ["Could caloric restriction be proposed in the future to prevent or treat neurodegenerative disorders such as Alzheimer's disease?", 'Finally, both exercise and caloric restriction enhance neurogenesis via different mechanisms suggesting that their combination may decrease the risk of neurodegenerative disease.'], ['INTERPRETATION: These data suggest that prostaglandin E(2) signaling via the EP2 receptor functions in the mutant SOD model and more broadly in inflammatory neurodegeneration to regulate expression of a cassette of proinflammatory genes.', 'Inhibition of EP2 signaling may represent a novel strategy to downregulate the inflammatory response in neurodegenerative disease.'], ['The implication of sirtuins in medically important areas such as diabetes, cancer, cardiovascular dysfunction and neurodegenerative disease has further catapulted them to a prominent status as potential targets for nutritional and therapeutic development.'], ['Oxidative stress produced by free radicals has been linked to the development of several diseases such as cardiovascular, cancer, and neurodegenerative diseases.'], ['DNA repair mechanisms constitute major defences against agents that cause cancer, degenerative disease and aging.'], ['Stimulation of cholinergic muscarinic receptors has been shown to provide substantial protection from DNA damage, oxidative stress and mitochondrial impairment, insults that may be encountered by neurons in development, aging, or neurodegenerative diseases.'], ["Neurodegenerative diseases like Alzheimer's disease and Parkinson's disease are gaining increasing relevance in our aging society."], ['BACKGROUND: Osteoarthritis, a degenerative disease that commonly affects older people, is manifested by pain and disability.'], ["BACKGROUND: The view of essential tremor (ET) as a degenerative disorder, which is now gaining support from postmortem studies, is at odds with traditional views of ET as a 'super-healthy' condition characterized by increased longevity and fertility."], ["Neurodegenerative illnesses such as Alzheimer's disease and their debilitating effects pose a major problem as their incidence increases.", "Although clinical management of neurodegenerative diseases usually involves symptomatic treatment, Colostrinin() (CLN), which has efficacy in counteracting neural degradation and in stimulating neural growth, might prove to be a more effective means to deal with the causes of Alzheimer's and other neurodegenerative diseases."], ['Distinct human neurodegenerative diseases share remarkably similar temporal emergence patterns, even though different toxic proteins are involved in their onset.', 'Recently, mechanistic links between the aging process and toxic protein aggregation, a common hallmark of neurodegenerative diseases, have been revealed.', 'The insulin/insulin-like growth factor 1 (IGF1) signalling pathway - a lifespan, metabolism and stress-resistance regulator - links neurodegeneration to the aging process.', 'Here we review this apparent paradox and delineate the therapeutic potential of manipulating the insulin/IGF1 signalling pathway for the treatment of neurodegenerative diseases.'], ['BACKGROUND: Misfolding and pathological aggregation of neuronal proteins has been proposed to play a critical role in the pathogenesis of neurodegenerative disorders.', "Alzheimer's disease (AD) and Parkinson's disease (PD) are frequent neurodegenerative diseases of the aging population.", 'CONCLUSION/SIGNIFICANCE: These results support the contention that Abeta directly interacts with alpha-syn and stabilized the formation of hybrid nanopores that alter neuronal activity and might contribute to the mechanisms of neurodegeneration in AD and PD.'], ["Among the zinc-dependent or 'classic' HDACs, we find that neurodegeneration is most sensitive to levels of Rpd3.", 'Our experiments suggest that longevity promoting strategies may be distinct from those that protect against neurodegeneration in Drosophila challenged with mutant human Htt.'], ['Oxidative stress is strongly implicated in the progressive decline of cognition associated with aging and neurodegenerative disorders.', 'A number of studies indicate that an increase in protein oxidation and lipid peroxidation is associated with age-related neurodegenerative diseases and cellular dysfunction observed in aging brains.'], ["Parkinson's disease is the second most common neurodegenerative disorders after Alzheimer's disease in the elderly.", 'Interleukin-1 (IL-1) is a cytokine that plays an important role in neurodegenerative disease.'], ['In addition to its unique combination of ChE and MAO enzyme inhibition, these results indicate that ladostigil displays neuroprotective activity against oxidative stress-induced cell apoptosis, which might be valuable for aging and age-associated neurodegenerative diseases.'], ['Elucidating the mechanisms underlying selective mitochondrial autophagy not only will help us to understand the mechanisms for erythroid maturation, but also may provide insights into mitochondrial quality control by autophagy in the protection against aging, cancer and neurodegenerative diseases.'], ['Mutations in LMNA give rise to diverse degenerative diseases related to premature ageing.'], ["This has a negative impact on the quality of daily life and is even more prominent in patients suffering from neurodegenerative and psychiatric disorders including Alzheimer's disease, schizophrenia, and depression."], ['We applied our criteria for PPMA: (1) asymmetric symptomatic action myoclonus, (2) >/=65 years of age, (3) cortical myoclonus physiology, (4) no dementia, (5) no associated features of defined neurodegenerative disorders, and (6) no secondary cause found.', 'PPMA is a unique syndrome with characteristic findings that differentiate it from dementias and defined neurodegenerative syndromes.'], ['However, in animals and patients with chronic neurodegenerative disease, multiple sclerosis, stroke and even during normal aging, systemic inflammation leads to inflammatory responses in the brain, an exaggeration of clinical symptoms and increased neuronal death.'], ['The progression of neurodegenerative diseases as well as healthy aging is accompanied by structural changes of the brain.'], ["Alzheimer's disease (AD) is the most common neurodegenerative disorders in the elderly."], ['Autophagy plays a role in innate and adaptive immunity, programmed cell death, as well as prevention of cancer, neurodegeneration and aging.'], ['There is a critical shortage of organs available for donation to patients suffering from degenerative diseases of various organ systems.'], ["The manifestation of misfolded proteins and aggregates is a hallmark of a range of neurodegenerative disorders including Alzheimer's disease, Parkinson's disease, amylotrophic lateral sclerosis, polyglutamine (polyQ) diseases, diabetes and many others."], ['Further, in age-associated neurodegenerative disease, oxidative damage may be exacerbated and associated with additional neuropathology.', 'In combination, antioxidants may be beneficial for promoting healthy brain aging and reducing the risk of neurodegenerative disease.'], ['In particular, (i) mitochondria-dependent programmed cell death pathways have been shown to be critical to PD-related dopaminergic neurodegeneration, (ii) many disease-causing proteins associated with familial forms of PD have been demonstrated to interact either directly or indirectly with mitochondria, (iii) aging-related mitochondrial changes, such as alterations in mitochondrial DNA, are increasingly being associated with PD, and (iv) anomalies in mitochondrial dynamics and intra-neuronal distribution are emerging as critical participants in the pathogenesis of PD.'], ['The sensitivity and specificity of the results are compared with those of a recent analysis, currently considered state of the art for MR studies of neurodegeneration.'], ['Endolysosomal proteases such as cysteinyl and aspartyl cathepsins play diverse roles in inflammatory autoimmune diseases, cancers, and neurodegenerative diseases.'], ['Thus, differential regulation of phosphorylation is important for NFT formation in neurodegenerative diseases with tau pathology.'], ["UNLABELLED: The number of elderly people is increasing considerably in our settings, and with that we have a matching increase in chronic-degenerative diseases - such as Parkinson's Disease (PD), which has balance-related symptoms associated and is increasingly more prevalent in the elderly population."], ['Accumulation of abnormal protein aggregates, detergent-insoluble (DI) proteins and amyloid in the brain are shared features of many neurodegenerative diseases.'], ['The workshop was sponsored by the National Institute of Neurological Disorders and Stroke (NINDS) and the National Institute on Aging (NIA) of the National Institutes of Health (NIH) and the Association for Frontotemporal Dementia (AFTD) with the express purpose of defining opportunities to improve the diagnosis and treatment of patients affected by a neurodegenerative disorder classified as one of the many variants of FTD.', 'The recognition that almost all forms of FTD are due to TDP-43 proteinopathies and tauopathies creates new opportunities for FTD drug discovery targeting pathways of TDP-43 and tau-mediated neurodegeneration.'], ['Iron accumulates in reactive form during aging, PD, and is involved in neurodegeneration.'], ['Since population aging has become a worldwide phenomenon, the burden of the age-related neurodegenerative diseases is expected to increase dramatically in both developed and developing nations.', "Alzheimer's disease is the most common neurodegenerative disorder among old people.", "We propose that an active and stimulating lifestyle in late life as well as an optimal control of vascular and other chronic diseases both at middle age and late life can be two possible intervention strategies to prevent or postpone the onset of dementia, and perhaps other neurodegenerative disorders such as Parkinson's disease."], ["Mitochondrial dysfunction is a consistent finding in neurodegenerative disorders like Alzheimer's (AD) or Parkinson's disease (PD) but also in normal human brain aging."], ['These findings indicate that in addition to its multiple neuroprotective characteristics, ladostigil also possesses antioxidant properties, which might be beneficial for the treatment of oxidative stress (OS) in aging and age-associated neurodegenerative diseases.'], ['FA and MD values of DTI may be used as novel biomarkers for the evaluation of neurodegenerative disorders.'], ['By studying mutations that occur in a group of genes associated with chronic neurodegeneration, the polyglutamine (polyQ) disorders, it has emerged that CAG/glutamine stretches play important roles in transcriptional regulation and protein-protein interactions.'], ['Work in these and other model systems has also provided evidence for the involvement of autophagy in disease processes, such as neurodegeneration, tumorigenesis, pathogenic infection and aging.'], ['This epidemiological survey was conducted to find features of degenerative diseases associated with loss of teeth in the elderly.', 'The degenerative diseases (DM, hypertension, heart disease) were determined by physical examination, laboratory testing and questionnaires.', 'The most common degenerative disease was hypertension (45.5%).', 'There was no significant association between degenerative diseases and the loss of teeth.', 'In conclusion, the loss of teeth was not associated with degenerative diseases, but may have been influenced by local factors such as a low demand for dental hygiene.'], ["Parkinson's disease (PD) is a common age-related neurodegenerative disease and it is critical to develop models which recapitulate the pathogenic process including the effect of the ageing process.", 'For the first time we demonstrate an age dependent neurodegenerative phenotype in human and mouse neurons.'], ['Biological variables and polymorphisms of different genes, important in neurodegeneration or reported to be associated with AD, were investigated as putative risk modifiers.'], ["BACKGROUND: Disease entities such as diabetes, neurodegeneration and cardiovascular disorders affect a significant portion of the world's population."], ["BACKGROUND: Parkinson's disease (PD) is a common neurodegenerative brain disease in developed countries where population of the elderly is high."], ["Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by cognitive impairment with insidious onset.", 'IGF-I is a critical promoter of brain development and neuronal survival, and plays a role in neuronal rescue during degenerative diseases.'], ['Throughout the last 2 decades, experimental evidence from in vitro studies and preclinical models of disease has demonstrated that reactive oxygen and nitrogen species, including the reactive oxidant peroxynitrite, are generated in parenchymal, endothelial, and infiltrating inflammatory cells during stroke, myocardial and other forms of reperfusion injury, myocardial hypertrophy and heart failure, cardiomyopathies, circulatory shock, cardiovascular aging, atherosclerosis and vascular remodeling after injury, diabetic complications, and neurodegenerative disorders.', 'This review focuses on the human data available on the pathophysiological relevance of the peroxynitrite-PARP pathway in a wide range of disparate diseases, ranging from myocardial ischemia/reperfusion injury, myocarditis, heart failure, circulatory shock, and diabetic complications to atherosclerosis, arthritis, colitis, and neurodegenerative disorders.'], ['The neuropathological assessment showed few neurofibrillary tangles (NFT) in the hippocampal formation compatible with Braak staging II, absence of amyloid deposits and other types of neurodegenerative lesions as well as preservation of neuron numbers in locus coeruleus.'], ['In this model, tangles develop independently but relatively slowly during aging; these represent neurodegeneration, but by themselves may not represent AD.', 'In contrast, amyloid may be the driving factor in AD, exacerbating neurofibrillary changes and other neurodegeneration.'], ['In recent years, we have reported on the presence of degenerating microglial cells, which are prominent in the brains of aged humans and humans with neurodegenerative diseases, and this has led us to propose a hypothesis stating that loss of microglia and microglial neuroprotective functions could, at least in part, account for aging-related neurodegeneration.'], ['Circadian instability associated with irritability and mood instability is observed in aging populations as well as in many psychiatric and neurodegenerative disorders.'], ['As scientists began associating mtDNA mutations with dozens of mysterious disorders, as well as the aging process and a variety of chronic degenerative diseases, it became increasingly evident that the information contained in this genome had substantial potential applications to improve human health.'], ['However, aside from clues revealed through examining age-related degenerative diseases, much remains uncertain about imbalances within these pathways during normal aging.'], ['The incidence of neurodegenerative diseases is higher in postmenopausal women that young women.', "Therefore, depression, neurodegenerative diseases such as Alzheimer's and Parkinson's diseases and memory or cognitive dysfunction should be considered, in some cases, a result of metabolic syndrome, and that postmenopausal women are more vulnerable that young women to these diseases Several studies have suggested that the molecular mechanism by which estradiol exerts its neuroprotective effects involves activation of the PI3-k signalling pathway, which is activated by insulin and IGF-1.", 'Numerous clinical studies have demonstrated that the incidence of neurodegenerative diseases in higher in postmenopausal women that young women.'], ['In contrast, little is known about the trajectory and specificity of any cognitive impairment associated with the fragile X premutation (i.e., "carrier status") or its relationship with the recently identified neurodegenerative disorder, fragile X-associated tremor/ataxia syndrome (FXTAS).'], ['Here we discuss the exciting potential of the growth factor and cytokine erythropoietin for the treatment of diseases such as cardiac ischemia, vascular injury, neurodegeneration, and diabetes through the modulation of cellular oxidative stress.'], ['However, recent experimental evidence demonstrates that mitochondrial DNA damage responses play important roles in aging and in the pathogenesis of neurodegenerative diseases.'], ['However, the protective effects of neuronal NEP expression on intraneuronal Abeta42 accumulation and neurodegeneration remain elusive.'], ['We provide a report of a physiological role for human ApoD (hApoD): Flies overexpressing hApoD are long-lived and protected against stress conditions associated with aging and neurodegeneration, including hyperoxia, dietary paraquat, and heat stress.'], ['Triose phosphate isomerase (TPI) deficiency glycolytic enzymopathy is a progressive neurodegenerative condition that remains poorly understood.', 'TPI has a well-characterized role in glycolysis, catalyzing the isomerization of dihydroxyacetone phosphate (DHAP) to glyceraldehyde-3-phosphate (G3P); however, little is known mechanistically about the pathogenesis associated with specific recessive mutations that cause progressive neurodegeneration.'], ['Comorbid conditions differed significantly by case/control status, with cases reporting significantly greater rates of chronic constipation, asthma, diabetes, high blood pressure, bladder or prostate cancer, neurological conditions and depression.'], ['Chronic age-related degenerative disorders, including the formation of chronic leg wounds, may occur due to aging of the stromal tissues and ensuing dysfunctional cellular responses.'], ['Deaths of adults 65+ years predominated in the 1990s and were largely due to degenerative diseases usually associated with aging.'], ['When mental regression is joined by tremor or motor deficits, neurodegenerative disease is commonly considered and the need for neuroimaging is underestimated.', 'Thus, CSH should be taken into account as an important differential diagnosis for demential and neurodegenerative diseases and neuroimaging should be demanded.'], ['Degeneration of microglial cells may be important for understanding the pathogenesis of aging-related neurodegeneration and neurodegenerative diseases.'], ['Nevertheless, the relationship between circadian cycles and autophagy is an intriguing area for future study and has implications for multiple human diseases, including aging, neurodegeneration and cancer.'], ["It was reported that the lack of neurodegeneration in a transgenic mouse model of Alzheimer's disease (AD) (Tg2576 mouse) was associated with increased TTR level in the hippocampus, and that chronic infusion of anti-TTR antibody into the hippocampus of Tg2576 mice led to increased local Abeta deposits, tau hyperphosphorylation and apoptosis."], ['In humans, autophagy has been implicated in many health and disease states, including cancer, neurodegeneration, aging and immunity, while phagocytosis plays a role in immunity and tissue homeostasis.'], ['An ApoD homologous gene in Drosophila, Glial Lazarillo, regulates resistance to stress, and neurodegeneration in the aging brain.'], ['Quantitative findings support the notion that decision making ability declines with age; moreover, it approximates the impairment observed in executive dysfunction due to neurodegeneration.'], ['Of the mammalian forkhead family members in the O class, FoxO1, FoxO3a and FoxO4 can fill a crucial void for the treatment of disorders that include aging, cancer, diabetes, infertility, neurodegeneration and immune system dysfunction.'], ['Recently, the role of neuroinflammation has attracted attention due to its slow onset, chronic nature and its possible role in the development of many different neurodegenerative diseases.', 'In the future, treatment of chronic neuroinflammation may help counteract aspects of neurodegenerative disease.'], ["Evidence has been accumulating for a role of inflammation in the development of Alzheimer's disease (AD), a progressive neurodegenerative disorder causing a common form of dementia in the elderly."], ['Druggable modifiers of proteotoxicity in degenerative diseases, notably the longevity modulators sirtuins, may constitute useful therapeutic targets.'], ['Like other neurodegenerative disorders such as Parkinson, Hungtington or prion diseases, AD is characterized by the formation of amyloid plaques in the central nervous system.'], ['In this report, we applied proteomics approaches to analyze 60 CSF samples derived from patients with neurodegenerative diseases such as MCI and AD.'], ["Parkinson's disease (PD) is one of the most common age-related neurodegenerative diseases caused by both environmental and inherited factors."], ['The Danubian Biobank Consortium (www.danubianbiobank.de) was initiated in 2005 as a network of Danube Universities and associated partner universities between Ulm and Budapest, with a major focus on case/control studies of aging disorders like vascular and metabolic diseases, Type2-diabetes, and neurodegenerative diseases.'], ['Manipulations of sirtuin activities cause activation of anti-apoptotic, anti-inflammatory, anti-stress responses, and the modulation of an aggregation of proteins involved in neurodegenerative disorders.', 'Recently, sirtuins were found to be disease-modifiers in various models of neurodegeneration.', 'Here, we review current data which support the putative therapeutic roles of sirtuin in aging and in neurodegenerative diseases and the feasibility of the development of sirtuin-based therapies.'], ['One clinical expression of enteric neurodegeneration is constipation.', 'However, the aetiology may be multifactorial as disturbances of epithelial, muscle or neural function may all result from neurodegeneration.', 'Understanding neurodegeneration in the enteric nervous system is key to developing treatments to reverse it.', 'Further research is needed to understand and potentially reverse enteric neurodegeneration.'], ['However, if stress persists, it may lead to chronic diseases, ranging from inflammation and cancer to degenerative diseases.'], ['In addition to imposing a heavy burden on family caregivers and society at large, AD and related neurodegenerative disorders are among the most complex and challenging in biomedicine.'], ['Autophagy has been associated with a growing number of pathological conditions, including cancer, myopathies, and neurodegenerative disorders.'], ["Mitochondrial dysfunction may play an important role in the pathogenesis of ageing and age-neurodegenerative diseases such as Alzheimer's disease (AD)."], ['OBJECTIVE: Present experience in diagnosis and treatment for referred otalgia secondary to cervical spine degenerative disease (CSDD).', 'RESULTS: The most common cause for referred otalgia in Group I was Temporomandibular joint (TMJ) dysfunction (46%); most common cervical spine finding in Group II was CSDD (88%).', 'CONCLUSION: As the population in America ages, CSDD in the elderly will begin to emerge as a major etiologic source for referred otalgia.', 'With a targeted medical history and physical examination one can use directed studies to diagnose CSDD-referred otalgia, and this pain can be alleviated with CSPT.'], ["Alzheimer's disease is a major neurodegenerative disease of the brain, the incidence of which increases dramatically in old age."], ['This data suggest that, in Tai Chi Chuan training, elderly people with degenerative joint diseases in the lower extremity should use caution when practicing Tai Chi Chuan.'], ['The purpose of this work is to review the changes that take place in the microtubule associated protein tau during neuronal development, aging and neurodegeneration.', 'In aging, or in neurodegenerative disorders, post translational modifications of tau, such as phosphorylation, could take place, and new tau isoforms may appear.', 'Thus, tau isoforms can be used as markers to follow neuronal development, aging or neurodegeneration.'], ['Cancer, aging, and neurodegeneration are all associated with DNA damage and repair in complex fashions.', 'Cancer and neurodegeneration appear to have complementary relationships to DNA damage and repair.', 'Neurodegeneration however occurs in nondividing neurons in which the persistence of apoptosis in response to reactive oxygen species is, itself, pathological.'], ['Lately, sirtuin activity has been tied to the pathogenesis of HIV, cancer and neurodegenerative disease.'], ["Alzheimer's disease (AD) is a chronic neurodegenerative disorder and the most common cause of dementia."], ["A large body of evidence indicates that sporadic Alzheimer's disease (AD) is a vascular disorder with neurodegenerative consequences and needs to be treated and managed as such.", 'The ensuing metabolic energy crisis initially carves up ischemic-sensitive neurons in the hippocampus and posterior parietal cortex setting up cognitive meltdown and progressive neurodegenerative and atrophic changes in the brain.'], ['For example, autophagic dysfunction is associated with cancer, neurodegeneration, microbial infection and ageing.'], ["Deficient repair activity for 8-hydroxy-2'-deoxyguanine (8-oxoguanine), a premutagenic oxidative DNA damage, has been observed in affected tissues in neurodegenerative diseases of aging, such as Alzheimer's disease, and in ischemia/reperfusion injury, type 2 diabetes mellitus, and cancer."], ['Since neurotrophic factors are not only responsible for neuronal development but also critical for the maintenance of neurons, they represent mediators of high interest within the research of neurodegeneration.', 'Thereby, NGF has been identified as a dynamic pattern during the time course of neurodegeneration in AD.'], ['mtDNA deletions in the brain have been associated with neurodegeneration and aging.', 'CONCLUSION: While aging and neurodegeneration in PD and AD are associated with accumulation of COX- cells and mtDNA deletions, the pathology of MS is not.'], ["Alternatively, inhibitors of SIRT2 may be useful in the treatment of neurodegenerative diseases such as Parkinson's disease."], ["Parkinson's disease (PD) is a common neurodegenerative disorder in the aging population, affecting more than 1% over the age of 65 years.", 'In this review, we present the molecular genetics of PD that are understood today, to help explain the pathways leading to neurodegeneration.'], ['This review presents comparative aspects of the biology of neuromelanin and lipofuscin, as well as a discussion of their hypothesized functions in brain and their possible roles in aging and neurodegenerative disease.'], ['METHODS: Three studies (2 of our own) were designed to evaluate the decline of these two components of attention in normal aging and two neurodegenerative diseases.'], ['Neuropathological findings in elderly suicide victims may include multiple neurodegenerative pathologies.', 'The burden and distribution of neurodegenerative diseases apart from AD, including SVD and LBD, should be assessed as possible pathophysiological factors contributing to late life suicide.'], ['These quantitative data may form the basis for further quantitative studies involving aging or some degenerative diseases that may affect cell bodies and/or dendritic trees of the Golgi-type I and/or Golgi-type II thalamic neurons.'], ['One clinical expression of enteric neurodegeneration is constipation.', 'However, the aetiology may be multifactorial as disturbances of epithelial, muscle or neural function may all result from neurodegeneration.', 'Understanding neurodegeneration in the enteric nervous system is key to developing treatments to reverse it.', 'Further research is needed to understand and potentially reverse enteric neurodegeneration.'], ['Changes in telomere length have been associated with ageing and with certain age-related degenerative diseases.', "These results need to be replicated in larger studies and in cohorts of other neurodegenerative disorders to determine specificity of changes to Alzheimer's patients."], ['Understanding the effect of aging on hMSCs is crucial for autologous therapy development in older subject whom degenerative diseases typically afflict.'], ['Alzheimer disease (AD) is characterized by progressive cognitive decline caused by synaptic dysfunction and neurodegeneration in the brain, and late-onset AD (LOAD), genetically classified as a polygenetic disease, is the major form of dementia in the elderly.'], ['Aging-related neurodegenerative diseases (NDs) are the culmination of many different genetic and environmental influences.', 'Prior studies have shown that RNAs are pathologically altered during the inexorable course of some NDs.', 'Recent evidence suggests that microRNAs (miRNAs) may be a contributing factor in neurodegeneration.', 'Research about miRNAs in the context of neurodegeneration is accumulating rapidly, and the goal of this review is to provide perspective for these new data that may be helpful to specialists in either field.', "Recently published studies pertaining to the roles of miRNAs in NDs--including Alzheimer's disease, Parkinson's disease and triplet repeat disorders-are described."], ['We discuss recent findings from our laboratory and others that identify androgen actions implicated in protecting the brain against neurodegenerative diseases and begin to define androgen cell signaling pathways that underlie these protective effects.', 'Continued elucidation of cell signaling pathways that contribute to protective actions of androgens should facilitate the development of targeted therapeutic strategies to combat AD and other age-related neurodegenerative diseases.'], ['This mouse displays all Alzheimer disease features of neurodegeneration and a broad timely resolution of tau pathology with hyperphosphorylation of tau at younger age (up to 6 months) and abnormal tau phosphorylation and tau aggregation in aged mice (by 10 months).', 'We show that there is an increased neurogenesis during tau hyperphosphorylation and cell cycle events during abnormal tau phosphorylation and tau aggregation preceding neuronal death and neurodegeneration.'], ['Neuronal death is a common feature in neurodegenerative diseases including Alzheimer disease (AD) and Parkinson disease (PD).', 'caloric restriction) may be a promising approach as anti-oxidative strategy against age-associated neurodegenerative diseases.'], ['Alterations in the proteasome proteolytic pathway have been thought to contribute to protein alterations associated with aging and, in fact, dysregulation of the UPS has been linked to several disease states including neurodegenerative diseases, malignancies, and inflammatory-related disorders.'], ['In addition, this strategy is amenable to produce MAbs and identify genes associated with specific disease states, including cancer, neurodegeneration, autoimmunity, and infection with pathogenic agents.'], ['Dysfunction of mitochondria has severe cellular consequences and is linked to ageing and neurodegeneration in human.'], ['In this review, we first describe the functions of some typical naturally originated multipotent anti-AD compounds, then summarize their structural features and reveal that phenolics with certain flexibility predominate in these agents, which are of significance to find novel multipotent drugs to combat AD and other neurodegenerative diseases as well.'], ['Excessive inflammation is considered as a critical factor in many human diseases, including cancer, obesity, type II diabetes, cardiovascular diseases, neurodegenerative diseases and aging.'], ['Biomarkers of ageing should help to characterise this biological age and, as age is a major risk factor in many degenerative diseases,could be subsequently used to identify individuals at high risk of developing age-associated diseases or disabilities.'], ['Although DNA repair has received little attention as a determinant of drug sensitivity, emerging knowledge of mutations and polymorphisms in key human DNA-repair genes may provide a rational basis for improved strategies for therapeutic interventions on a number of tumors and degenerative disorders.'], ["Alzheimer's disease (AD) is a progressive neurodegenerative disorder of the elderly that is characterized by memory loss."], ['Autophagy principally serves an adaptive role to protect organisms against diverse pathologies, including infections, cancer, neurodegeneration, aging, and heart disease.'], ['Pairwise comparisons suggested that neuronal damage associated with NAA/Cr decreases was mainly observed in individuals with ADC, raising issues of synergism between HIV infection and age and possible acceleration of neurological deterioration in an aging HIV-positive population.'], ['These include two trafficking proteins, a conserved cellular scaffold-type protein that modulates G protein signaling, a protein of unknown function, and one gene reported to cause neurodegeneration in knockout mice.'], ['It is well known that iron accumulates in the brains of patients with various neurodegenerative diseases.'], ['The CNS appears to be susceptible to anesthetic neurotoxicity primarily at the extremes of ages, possibly via different pathways: in the neonate, during the period of most intense synaptogenesis, anesthetics can induce excessive apoptosis; in the aging CNS subtle cognitive dysfunction can persist long after clearance of the drug, and processes reminiscent of neurodegenerative disorders may be accelerated (Eckenhoff et al.'], ["Alzheimer's Disease (AD) is a progressive, irreversible neurodegenerative disease."], ['These observations further support the view of MPS as a marker of emerging degenerative brain pathologies.'], ['Neurodegenerative diseases are progressive and incurable and are becoming ever more prevalent.'], ['Melatonin is a recognized antioxidant with high potential as a protective agent in many conditions related to oxidative stress such as neurodegenerative diseases, ischemia/reperfusion syndromes, sepsis and aging.'], ['There is increasing evidence linking mitochondrial dysfunction to neurodegenerative diseases.', 'Mitochondria are critical regulators of cell death, a key feature of neurodegeneration.', 'Mutations in mitochondrial DNA and oxidative stress both contribute to ageing, which is the greatest risk factor for neurodegenerative diseases.', "In the case of Huntington's disease (HD), recent evidence suggests that the coactivator PGC1alpha, a key regulator of mitochondrial biogenesis in respiration, is down-regulated in patients with HD and in several animal models of this neurodegenerative disorder."], ['(2) UCPs may attenuate ROS production and protect against oxidative damage, degenerative diseases and ageing.'], ['Our results thus highlight the importance of access to reliable health care and comprehensive coverage for rational medication use in the management of degenerative diseases.'], ["Alzheimer's disease is a complex neurodegenerative disorder, with aging, genetic and environmental factors contributing to its development and progression."], ['Epidemiological studies show a positive, dose-dependent relationship between plasma total homocysteine (tHcy) concentration and neurodegenerative disease risk.', 'HHcy occurs commonly in the elderly and can contribute to age-related neurodegeneration.'], ['Agents that stimulate NPD1 biosynthesis, NPD1 analogs, or dietary regimens may be useful as new preventive/therapeutic strategies for neurodegenerative diseases.'], ['BACKGROUND: Fragile X-associated tremor/ataxia syndrome (FXTAS) is a recently described, underrecognized neurodegenerative disorder of aging fragile X mental retardation 1 (FMR1) premutation carriers, particularly men.'], ['Several studies have sought to demonstrate that neurodegeneration during disease and in old age is associated with reduced neurotrophic support.', 'Recently, a novel way in which neurotrophins could contribute to neurodegeneration has been suggested.', 'Whether elevated levels of proNGF in targets or of sortilin in neurons contribute to known patterns of age- and disease-related neurodegeneration has not been previously investigated.'], ["Idiopathic Parkinson's disease (PD) is a progressive neurodegenerative disease characterized by dopaminergic neuronal loss within the substantia nigra."], ['If the generation of free radicals exceeds the protective effects of antioxidants, and some co-factors, this can cause oxidative damage which accumulates during the life cycle, and has been implicated in aging, and age dependent diseases such as cardiovascular disease, cancer, neurodegenerative disorders, and other chronic conditions.'], ['It is a progressive neurodegenerative condition that is estimated to dramatically increase in prevalence as the elderly population continues to grow.'], ['Dementia represents the most common neurodegenerative disorders affecting approximately 5% of the elderly population over age 65 years.'], ['BACKGROUND CONTEXT: Lumbar intervertebral disc degeneration (DD) precedes degenerative diseases of the lumbar spine.'], ['Although degenerative diseases of the knee joint may also have detrimental effects on the PTFJ until now, details of arthritic affection of PTFJ in the elderly who have severe femorotibial arthritis have not been described.'], ['The family of 70 intermediate filament genes (including those encoding keratins, desmins, and lamins) is now known to be associated with a wide range of diverse diseases, at least 72 distinct human pathologies, including skin blistering, muscular dystrophy, cardiomyopathy, premature aging syndromes, neurodegenerative disorders, and cataract.'], ['This article reviews the mechanism of action of cannabinoids, examines marketed agents and those in clinical trials, and addresses their role in treatment of chronic pain, cancer, neurodegenerative diseases, and HIV/ AIDS.'], ['Most recently, there has been increased attention on the development of new cognitive techniques to treat persons with progressive neurodegenerative conditions such as Alzheimer disease.'], ["Alterations in the autophagy-lysosomal degradation pathway have been described in normal brain aging and in age-related neurodegenerative diseases including Alzheimer's (AD) and Parkinson's (PD)."], ["Alzheimer's disease (AD) is a neurodegenerative disease characterized by a progressive loss of neurotransmitters, as well as acetylcholinesterase and nicotinic acetylcholine receptors in the central nervous system that leads to learning and memory deficits, among other problems."], ['Hirano bodies are paracrystalline F-actin-rich aggregations associated with a variety of conditions including aging, and neurodegenerative diseases.'], ['The evolution oF cognitive impairment over the liFe span may clariFy whether schizophrenia is best characterized as a neurodevelopmental or neurodegenerative disorder.'], ["The present review discusses the pharmacological basis of the use of W. somnifera in various central nervous system (CNS) disorders, particularly its indication in epilepsy, stress and neurodegenerative diseases such as Parkinson's and Alzheimer's disorders, tardive dyskinesia, cerebral ischemia, and even in the management of drug addiction."], ['The heat-shock response is implicated in a variety of conditions including ischemic diseases, infection and immunity, neurodegeneration, and aging.'], ['The so-called "cholinergic hypothesis" assumes that degenerative dysfunction of the cholinergic system originating in the basal forebrain and innervating several cortical regions and the hippocampus, is related to memory impairment and neurodegeneration found in several forms of dementia and in brain aging.'], ['The mammalian ortholog SIRT1 regulates physiological processes including apoptosis, fat metabolism, glucose homeostasis, and neurodegeneration.'], ['Chronic accumulation of oxidized proteins is linked to neurodegenerative disorders and ageing.'], ['Such low mortality due to degenerative diseases was predetermined by the small percent of the elderly in the age structure (8.4%), which was 2.5-fold lower compared to Russia and developed countries.'], ['These enzymes protect cells from oxidative stress and have been implicated in delaying the aging process and progression of neurodegenerative diseases.'], ['Frontal brain dysfunction may underlie depression both in cerebrovascular disease and neurodegenerative disorders.'], ["Animal experiments and cell biology studies have provided evidence that both estrogens and androgens can play a protective role against Alzheimer's disease (AD) related neurodegeneration."], ['Alzheimer disease (AD) is a neurodegenerative disease that affects cognition, behavior and function.'], ['Laboratory investigation and imaging studies should be based upon the initial findings with emphasis on excluding diagnoses of neurodegenerative diseases, amyloidosis, diabetes, anemia, and vitamin deficiency as the cause.'], ['Thus, for older adults with HIV, declines in both olfaction and psychomotor skills may be early signs of a developing neurodegenerative disorder.'], ['It is now well established that formation and accumulation of AGEs progress during normal aging, and at an extremely accelerated rate under diabetes, thus being implicated in various types of AGE-related disorders such as diabetic vascular complications, neurodegenerative diseases and cancers.'], ['Late-onset seizures are frequently caused by cerebrovascular disease, head trauma, degenerative disorders or CNS tumors.'], ['We envisage that the deorphanisation of the remaining orphan G protein-coupled receptors will further advance our knowledge of nervous system pathophysiology and unveil additional targets for new therapeutic approaches to human diseases, including psychosis, depression, anxiety, pain and aging-associated neurodegenerative disorders.'], ["Parkinson's disease is a common neurodegenerative disorder of unknown cause."], ["Two psychiatric disease cohorts--defined by chronic neurodegeneration (Alzheimer's) or lack thereof (schizophrenia)--were included."], ["Aging-related mitochondrial dysfunction underlies many common neurodegenerative disorders diseases, including Alzheimer's disease (AD).", 'Both are early events in aging and especially in the pathogenesis of aging-related severe neurodegeneration.'], ['Neurodegenerative disorders of the aging population affect over 5 million people in the US and Europe alone.', 'Based on these studies, considerable advances have been made in the past years in developing novel experimental models of neurodegenerative disorders.'], ['In this survey we sought to discover demographic information concerning those who provide front-line care to this population of aged Australians, and we sought also to ascertain how much education in caring for residents who suffer specifically from neurodegenerative disorders (the dementias) and mental illness was provided by the facilities to those who care for such older people.'], ['CONCLUSIONS: The improved body redox status in healthy volunteers undergoing a cycle of hydropinic therapy suggests major benefits from sulfurous water consumption in reducing biomolecule oxidation, possibly furnishing valid protection against oxidative damage commonly associated with aging and age-related degenerative diseases.'], ['The number of elderly individuals in our population is rapidly rising and age-associated neurodegenerative disease is becoming more prevalent.'], ["OBJECTIVE: Insulin-like growth factor-I (IGF-I) deficiency may be involved in cognitive deficits seen with aging and in neurodegenerative diseases such as Alzheimer's disease (AD)."], ['Recently, our laboratory has demonstrated its neuroprotective effects to counter neuronal loss in neurodegenerative diseases.'], ['Progressive supranuclear palsy (PSP) is a neurodegenerative disorder pathologically characterized by neuronal loss and gliosis mainly in specific subcortical nuclei, but also in the cerebral cortex.'], ["Recent structural and functional studies of mitochondria have revealed that abnormalities in mitochondria may lead to mitochondrial dysfunction in aged individuals and those with neurodegenerative diseases, including Alzheimer's disease (AD)."], ['These studies effectively rule out any mechanism for the removal of S-cdA or 8-OH-dA from DNA that requires spontaneous glycosidic bond hydrolysis, and further support the proposed role of cPu in the neurodegeneration observed in xeroderma pigmentosum patients who lack NER.'], ['Furthermore, a disturbed hormone status may partially act towards the manifestation of neurodegenerative diseases.'], ["Associations of radiologists' reporting of i) osteoarthritis, ii) degenerative disease and iii) individual radiographic features of OA, with patient characteristics and clinical details on the GPs' requests, were assessed."], ['Dementia with Lewy bodies (DLB) represents the second most frequent type of neurodegenerative dementia in the elderly.'], ['These results indicate that both Activin-A and -B share the potential to induce neuroprotective activity and thus may have positive impact on aging and neurodegenerative diseases to retard the accelerated rate of neuronal degeneration.'], ["Parkinson's disease (PD) is the most common cause of the parkinsonian syndromes and the most frequent neurodegenerative disease after Alzheimer's disease."], ['First, the compromised ability to perceive pain because of loss of sensory neurons and other comorbid conditions such as dementia and degenerative joint diseases make the assessment of severity source and localization of pain very difficult.'], ['Various neurodegenerative diseases are also associated with changes in mitochondrial function, and these changes both recapitulate and extend those seen in "normal" aging.', 'Unfortunately, attempts to treat neurodegenerative diseases by treating mitochondria-related pathology have thus far minimally impacted affected patients.', 'A better understanding of how mitochondrial function changes in aging and neurodegenerative diseases, though, now suggests new approaches to mitochondrial therapy may prove more efficacious.', 'Increasing ETC capacity, increasing oxidative phosphorylation, or decreasing mitochondrial ROS may yet prove useful for the treatment of brain aging and neurodegenerative diseases, and accomplishing this seems increasingly feasible.', 'This review will discuss the role of mitochondrial function and dysfunction in aging and neurodegenerative diseases, and will focus on potential treatment strategies.'], ['Amyotrophic lateral sclerosis (ALS) is a progressive and fatal neurodegenerative disease with no known effective treatment or cure.'], ['It is essential to characterize the proteome of various regions of human brain because most, if not all, neurodegenerative diseases are region-specific.', 'A number of proteins known to be associated with neurodegenerative diseases were also identified.', 'Detailed characterization of these proteins will supply the necessary information to appropriately interpret proteins associated with aging and/or age-related neurodegenerative diseases.'], ['Due to similarities in cellular and molecular processes, which govern neuronal plasticity in humans and honeybees, the author proposes that the honeybee can be used as a potential and relatively simple model system for understanding human olfactory dysfunction during aging and in neurodegenerative diseases.'], ['Previous findings suggest that the antioxidant-iron chelator green tea polyphenol (-)-epigallocatechin-3-gallate (EGCG) may have a neurorescue impact in aging and neurodegenerative diseases to retard or even reverse the accelerated rate of neuronal degeneration.'], ["The marked microglial reaction in normal aging human substantia nigra, together with the previously reported 35-80% pigmented neuron loss, indicates the presence of a powerful pathologic process that may be additive with specific age-related neurodegenerative diseases, including Parkinson's disease."], ['Activation of sirtuin extends lifespan and promotes longevity and healthy aging in a variety of species, potentially delaying the onset of age-related neurodegenerative disorders.', "In mammalian systems, sirtuin activators protect against axonal degeneration, poly-glutamine toxicity and microglia-mediated amyloid beta toxicity, suggesting the potential therapeutic value of sirtuins in patients with neurodegenerative diseases, such as Alzheimer's disease."], ['Our findings suggest that both metabolites may contribute to the overall neuroprotective activity of their respective parent compounds, further implicating rasagiline and ladostigil as potentially valuable drugs for treatment of a wide variety of neurodegenerative disorders of aging.'], ["Parkinson's disease and Alzheimer's disease are the most common neurodegenerative diseases in the elderly population."], ['We suggest that this literature supports the claim that physical activity enhances cognitive and brain function, and protects against the development of neurodegenerative diseases.'], ["Impaired axonal transport may promote pathogenesis in neurodegenerative disorders, such as Alzheimer's disease (AD)."], ["Alzheimer's and prion diseases belong to a category of conformational neurodegenerative disorders [Prusiner SB (2001) N Eng J Med344, 1516-1526; Sadowski M & Wisniewski T (2007) Curr Pharm Des 13, 1943-1954; Beekes M (2007) FEBS J 274, 575]."], ['This increase is accompanied by the concomitant decline in cognitive and motor performance in the elderly population, even in the absence of neurodegenerative diseases.', "Epidemiological studies have shown that consumption of diets rich in antioxidant and anti-inflammatory agents, such as those found in fruits and vegetables, may lower the risk of developing age-related neurodegenerative diseases such as Parkinson's disease and Alzheimer's disease.", 'Thus, nutritional intervention may exert therapeutic protection against age-related deficits and neurodegenerative diseases.'], ['The calpain gene family and its inhibitors have diverse effects, many related to protein turnover, which appear to affect a range of phenotypes such as diabetes, exercise-induced muscle injury, and pathological events associated with degenerative neural diseases in humans, fertility, longevity, and postmortem effects on meat tenderness in livestock species.'], ['Cellular expression of L-kynurenine aminotransferases (KAT I and II) in the avian and rodent retina and its changes in retinal development and neurodegeneration have been documented.', 'CONCLUSIONS: Presence of kynurenine aminotransferases in CAm in the human retina and optic nerve suggest that both enzymes may be involved in mechanisms of retinal ageing and neurodegeneration leading to CAm formation.'], ['Finally, more elderly patients presented neurological deterioration, although mortality was not significantly different.'], ['The SIR2 gene promotes longevity in a variety of organisms and may underlie the health benefits of caloric restriction, a diet that delays aging and neurodegeneration in mammals.', 'In the inducible p25 transgenic mouse, a model of AD and tauopathies, resveratrol reduced neurodegeneration in the hippocampus, prevented learning impairment, and decreased the acetylation of the known SIRT1 substrates PGC-1alpha and p53.', 'Furthermore, injection of SIRT1 lentivirus in the hippocampus of p25 transgenic mice conferred significant protection against neurodegeneration.', 'Thus, SIRT1 constitutes a unique molecular link between aging and human neurodegenerative disorders and provides a promising avenue for therapeutic intervention.'], ['Mitochondrial DNA (mtDNA) mutations are a common cause of human disease and accumulate as part of normal ageing and in common neurodegenerative disorders.'], ['Idiopathic and genetic causes together with inflammatory and degenerative disorders of ageing have been postulated as contributing to PD.', 'Pro-inflammatory responses are seen in PD patients consistent with apoptotic neurodegeneration.'], ['In a broader context, there is growing interest in dietary HDAC inhibitors and their impact on epigenetic mechanisms affecting other chronic conditions, such as cardiovascular disease, neurodegeneration and aging.'], ['A link between dermatopathological and neurological entities has been implied due to clinical case studies revealing an association between bullous pemphigoid and age-related neurodegenerative disorders.', 'Many neurodegenerative disorders display a specific pattern of neuroanatomical involvement, thus the regionally variable expression of collagen XVII offers new prospects for research.'], ["The mechanistic basis for these signs is unclear, but is likely to be multifactorial, with possible factors including an age-associated decline in dopaminergic nigrostriatal activity, the early development of neurodegenerative (Lewy body or Alzheimer's type) pathologies in the basal ganglia, or the accumulation of vascular pathology in the brain."], ["Prolonged stress in the elderly people may induce neurodegenerative diseases such as Alzheimer's disease."], ['Many lines of evidence suggest that mitochondria have a central role in ageing-related neurodegenerative diseases.', 'However, despite the evidence of morphological, biochemical and molecular abnormalities in mitochondria in various tissues of patients with neurodegenerative disorders, the question "is mitochondrial dysfunction a necessary step in neurodegeneration?"', "In this review, we highlight some of the major neurodegenerative disorders (Alzheimer's disease, Parkinson's disease, Amyotrophic lateral sclerosis and Huntington's disease) and discuss the role of the mitochondria in the pathogenetic cascade leading to neurodegeneration."], ['Advanced glycation endproducts (AGEs) accumulate with age and are associated with degenerative diseases.'], ['Because osteoporosis is a particularly prevalent comorbidity in the elderly population, it must be a concern in all elderly patients with degenerative disease of the lumbar spine.'], ['However with demographic changes towards an aging population in the richer countries, leading to growing demands of ways to combat degenerative disease, science would be remiss not to explore every potential medical solution.'], ['The onset of age-related neurodegenerative diseases superimposed on a declining nervous system could exacerbate the motor and cognitive behavioral deficits that normally occur in senescence.', "In this regard, epidemiological studies indicate that consumption of diets rich in antioxidants and anti-inflammatory compounds, such as those found in fruits and vegetables, may lower the risk of developing age-related neurodegenerative diseases, such as Alzheimer's or Parkinson's diseases (AD and PD)."], ['After human reproductive age, these inflammatory responses contribute also to development of chronic degenerative diseases.'], ['BACKGROUND: Subclinical vascular or degenerative lesions occur in the brain before the clinical expression of dementia.'], ['Thus, PARP plays an important role in the pathogenesis of several diseases, such as, stroke, myocardial infarction, circulatory shock, diabetes, neurodegenerative disorders, including Parkinson and Alzheimer diseases, allergy, colitis and other inflammatory disorders.'], ["On MRI, atrophy is the primary hallmark of neurodegenerative dementias including Alzheimer's disease (AD), while vascular dementia is characterized by the presence of ischemic vascular damage, such as territorial infarcts, lacunes, and white matter hyperintensities.", 'In the present article we present results of four recent MRI studies suggesting the additional involvement of small vessel disease in neurodegenerative disorders.'], ['Functional magnetic resonance imaging (fMRI) is a noninvasive neuroimaging technique that can be used to study the neural correlates of complex cognitive processes, and the alterations in these processes that occur in the course of normal aging or superimposed neurodegenerative disease.'], ["Alzheimer's disease is an irreversible, progressive neurodegenerative disorder leading invariably to death, usually within 7-10 years after diagnosis and is the leading cause of dementia in the elderly.", "Not only is Alzheimer's disease a tragic disease in which people suffer from neurodegeneration in the years to come, it also becomes an incredible burden on the public health system."], ['As neuronal degeneration is a major pathophysiological aspect of human aging, understanding the mechanism of SIRT1 neuroprotection promises novel strategies in clinical intervention of neurodegenerative diseases.'], ['Disturbed methyl group metabolism may be the link between hyperhomocysteinemia and neurodegeneration.'], ["Advanced age and presence of intracerebral amyloid deposits are known to be major risk factors for development of neurodegeneration in Alzheimer's disease (AD), and both have been associated with microglial activation."], ['However attempts to unravel the early, initiating factors in the pathogenesis of dopaminergic neurodegeneration and PD have been limited by the lack of a suitable animal model.', 'PPID results from neurodegeneration of the dopaminergic periventricular neurons that innervate the intermediate lobe of the pituitary.', 'In this review, the similarities and differences in the pathology of neurodegeneration in PPID and PD are compared.', 'The potential utility of the horse as a model of spontaneous dopaminergic neurodegeneration is discussed.'], ['INTRODUCTION: Many older people suffer from degenerative and chronic diseases resulting in chronic pain.'], ['The demand for treatment strategies for damaged musculoskeletal tissue is continuously growing, especially with the increasing number of older people with degenerative diseases of the skeletal system such as osteoarthritis (OA).', 'Because depletion of multipotent cells has been implicated in degenerative joint diseases, cell-based therapies have been proposed for tissue regeneration, especially for cartilage repair.'], ['Seven of the patients had a CNS degenerative disorder and two had a systemic illness known to be associated with myoclonus.'], ['Autosomal dominant spinocerebellar ataxias (AD-SCAs) form a clinically and genetically heterogeneous group of neurodegenerative disorders.'], ["Parkinson's disease (PD) is a progressive neurodegenerative disorder affecting mainly the elderly, although a small proportion of PD patients develop the illness at a much younger age.", "Given that dopaminergic neurons in the substantia nigra are relatively vulnerable to 'stress' and the region has a large population of microglia in comparison to other CNS structures, these events may easily trigger neurodegeneration."], ['AGEs have been implicated in the development of many of the pathological sequelae of diabetes and aging, such as diabetic microangiopathy, ischemic heart disease and neurodegenerative diseases.', "How about the effects of AST-120 on Alzheimer's disease, another AGE-related neurodegenerative disorder?"], ['Lysosomal storage diseases (LSDs) are debilitating genetic conditions that frequently manifest as neurodegenerative disorders.'], ['Because we know that zinc contributes to deposit formation in neurodegenerative diseases, we tested the hypothesis that zinc might be involved in deposit formation in AMD.'], ['Defects in these steps of import have been shown to lead to oxidative stress, neurodegenerative diseases, and metabolic disorders.'], ['The association between apolipoproteins and neurodegeneration is unclear.'], ['Of greater interest is the potential neuroprotective effect of rasagiline and its major metabolite, 1(R)-aminoindan, which may have great utility in a wide variety of neurodegenerative disorders of aging.'], ['The data that have accumulated from use of the 2VO model in the rat permit an understanding of the causative role played by cerebral hypoperfusion in neurodegenerative diseases.', 'Thorough characterization of the model suggests that 2VO in the rat is suitable for the development of potentially neuroprotective strategies in neurodegenerative diseases.'], ['Increased oxidative stress is thus also considered to play a role in the pathogenesis of age-related neurodegenerative disorders such as Alzheimer disease (AD).'], ["A malfunction of the ER stress response caused by aging, genetic mutations, or environmental factors can result in various diseases such as diabetes, inflammation, and neurodegenerative disorders including Alzheimer's disease, Parkinson's disease, and bipolar disorder, which are collectively known as 'conformational diseases'."], ['Ginsenosides or ginseng saponins as the active ingredients have antioxidant, anti-inflammatory, anti-apoptotic and immunostimulant properties, which raised speculations that these compounds could positively affect neurodegenerative disorders and delay neuronal aging.', 'Thus, neuroprotective actions of ginsenosides could come about as a valuable option to slow down neurodegenerative diseases.'], ['Therefore, it was hypothesized that reduced brain Se bioavailability may be involved in the pathogenesis of neurodegenerative disease and normal ageing.'], ['The elderly population, in particular those with certain psychiatric and neurodegenerative illnesses, also can exhibit these behaviors.'], ['However, the increases in chronic degenerative diseases that are partly due to over-nutrition and obesity will be a large burden in an aging society.'], ['We have been performing studies of developing and adult neurons aimed at understanding the effects of global and telomere-directed DNA damage responses in neuronal plasticity and survival in the contexts of aging and neurodegenerative disorders.', "Deficits in specific DNA repair proteins, including DNA-PKcs and uracil DNA glycosylase (UDG), render neurons vulnerable to adverse conditions of relevance to the pathogenesis of neurodegenerative disorders such as Alzheimer's disease and stroke.", 'A better understanding of the molecular mechanisms by which neurons respond to global and telomere-specific DNA damage may reveal novel strategies for prevention and treatment of neurodegenerative disorders.'], ['A growing number of human neurodegenerative diseases are associated with the expression of misfolded proteins that oligomerize and form aggregate structures.', 'In addition to being genetically tractable, C. elegans have rapid growth rates and short life-cycles, providing unique advantages for modeling neurodegenerative diseases of aging caused by the stress of misfolded proteins.'], ['The study took place in the Movement Disorders Unit, Rabin Medical Center, Petah Tiqva, Israel among 26 patients with recurrent falls who had no clinical evidence of a neurodegenerative disease.'], ['These metabolic alterations may be important indicators of low folate status, hyperhomocysteinemia, and neurodegenerative diseases.'], ['Increased longevity is compromised for the quality of life due to prevalence of metabolic derangements and systemic degenerative disorders, as a result of lifestyle changes in modern days.', 'In light of preclinical and clinical studies on adult stem cells, bone marrow transplantation in healthy elderly individuals is likely to promote rejuvenation and prevent onset of degenerative disorders as well as cure prevailing disorders if any.'], ['Multiple regression analysis of regional WMH, vascular risk factors, and diagnosis suggest that these spatial differences may result from the additive effects of vascular and degenerative injury.'], ["BACKGROUND: Parkinson's disease (PD) is the most common neurodegenerative movement disorder, characterized clinically by resting tremor, bradykinesia, postural instability and rigidity."], ['AD is the most frequent neurodegenerative disease of older Americans.'], ['Ataxia telangiectasia (AT), a human hereditary disorder resulting from mutations in the ATM gene, is characterized by a high incidence of lymphoid malignancies, neurodegeneration, immunodeficiency, premature aging, elevated radiosensitivity, and genomic instability.', 'Since then, it has been proposed that oxidative stress contributes to the clinical phenotype of AT, especially carcinogenesis and neurodegeneration, and several animal studies were conducted to determine whether exogenous antioxidants mitigate the symptoms of AT.'], ["Alzheimer's disease (AD) is the most common neurodegenerative disorder in the elderly and is also considered a progeroid genetic syndrome."], ['Citicoline has also been shown to be able to inhibit mechanisms of apoptosis associated to cerebral ischemia and in certain neurodegeneration models, and to potentiate neuroplasticity mechanisms.', 'The other major indication of citicoline is for treatment of senile cognitive impairment, either secondary to degenerative diseases (e.g.'], ['Mitochondrial changes are at the centre of a wide range of maladies, including diabetes, neurodegeneration and ageing-related dysfunctions.'], ['Moreover, the deregulation of PTPC has been involved in several major human pathologies such as cancer, neurodegeneration, ischemia/reperfusion, aging, as well as hepatotoxicity.'], ['It is upregulated in many different forms of neurodegeneration and is thought to represent a defense response against neuronal damage.'], ['First, vitamin C is now known to be involved in several novel physiological phenomena including stem cell differentiation and respiratory development, which likely require pharmacological levels of vitamin C. Secondly, the growing recognition that many ageing-related diseases, including heart disease, neural degeneration and cancer, may have a contributing oxidative damage factor that might be reduced by dietary antioxidants such as vitamin C. In this paper, we hypothesize that high serum-level vitamin C provides important, broad-ranging therapeutic benefits in treating ageing-related degenerative diseases.'], ['Reactive oxygen species (ROS) play a crucial role not only in the physiological signal transduction but also in the pathogenesis of several human diseases such as atherosclerosis, neuro-degenerative diseases, metabolic disorders, aging or cancer amongst others.'], ['Alzheimer disease is a progressive degenerative disorder of the brain characterized by a slow, progressive decline in cognitive function and behavior.'], ["Defective DNA damage response in older human age can generate neurodegenerative disorders such as Alzheimer's or Parkinson diseases."], ['The objectives of this study were to evaluate patients with the prevalence of risk for transfusion, the effect of inflammation on ferritin (F) values and functional iron deficiency in elderly patients with advanced degenerative arthropathy scheduled for hip or knee replacement.'], ["The accumulation of oxidized proteins is known to be linked to some severe neurodegenerative diseases like Alzheimer's, Parkinson's and Huntington's disease."], ['And yet, the quality of life during those additional years is often significantly diminished by the effects of age-related, degenerative diseases, including age-related macular degeneration (AMD), the leading cause of blindness in the elderly worldwide.'], ['A significant increase of the elderly in populations of developed countries is followed by increase morbidity and mortality from main age-related diseases--cardiovascular and neuro-degenerative, cancer, diabetes mellitus, declining in a resistance to infections.'], ['Here, we summarize current literature on DNA damage responses in the mammalian CNS in aging and neurodegeneration.', 'Together, the results reviewed here advocate that mitochondrial DNA damage response plays an important role in aging and in the pathogenesis of neurodegenerative diseases.'], ['In addition, this terrible neurodegenerative disease will increase exponentially over the next two decades due to longer lifespan and an aging "baby-boomer" generation.'], ['This paper reviews current ideas regarding DHA and the oxygenated DHA derivative NPD1, intrinsically triggered biolipid neuroprotectants that along with their associated rescue pathways, contribute to life-or-death decisions of brain cells during homoeostasis, aging and neurodegenerative disease.'], ['Here, we review the involvement of GPCRs and their lipid environment in the development of the major human pathologies associated with aging such as cancer, neurodegenerative disorders and cardiovascular pathologies.'], ['Although an increasing number of genetic factors that may affect the risk of neurodegenerative disorders are being identified, number of findings show that dietary factors play major roles in determining whether the brain age successfully of experiences neurodegenerative disorders.'], ['Vitamin D (or certain of its analogues) could be of interest in the prevention of various aspects of neurodegenerative or neuroimmune diseases.'], ["Thus, hESCs may provide an unlimited cell source for replacement in a number of aging-related neurodegenerative diseases such as Parkinson's disease and Alzheimer's disease as well as other neurological disorders including spinal cord injuries."], ['AGEs increase during aging obviously preferentially in glutamatergic pyramidal neurons in cerebral cortical layers prone to neurodegeneration.'], ['Programmed cell death (PCD) is executed by an active cellular process and is extensively involved in many physiological and pathological processes, including embryonic development and human degenerative diseases.'], ['In fact, there is increasing evidence that disturbance of the normal balance and localization of cathepsins may contribute to neurodegeneration in AD [Nakanishi H. Neuronal and microglial cathepsins in aging and age-related diseases.'], ['Neurodegenerative diseases present the additional problem that cell death signals may interfere with the viability of grafted cells.'], ['The CNS is sensitive to oxidative damage during aging or disease; excellent transgenic models of specific neurodegenerative diseases have been created that reproduce oxidative stress components of the corresponding human disorder.'], ['FUTURE DIRECTIONS: As several metabolic diseases and age-related degenerative disorders are closely associated with oxidative processes in the body, the use of herbs and spices as a source of antioxidants to combat oxidation warrants further attention.'], ["Alzheimer's disease is an age-related progressive neurodegenerative disorder with an enormous unmet medical need."], ["Alzheimer's disease is the most common neurodegenerative disorder in the elderly."], ['While the role of apoptosis in neurodegeneration is well documented in tissue culture and transgenic animal models, in human postmortem AD brain its occurrence and role are discussed controversially.', 'Given the short duration required for the completion of apoptosis and the chronic progressive course of neurodegeneration in Alzheimer disease and related disorders, the detection of rare neurons displaying morphological signs of apoptosis and expression of the activated key-executing enzyme Csp-3 is realistic, although there is significantly increased incidence of cells with DNA fragmentation, mainly glia, and markers for a "proapoptotic" environment in the aged human brain indicate increased susceptibility of neurons to metabolic and other noxious factors.'], ['BACKGROUND AND AIM: A large number of mitochondrial DNA (mtDNA) mutations have been implicated in degenerative diseases and aging.'], ['PURPOSE OF REVIEW: Recent technological developments in neuroimaging have led to new technologies that provide measures of the cerebral pathology of neurodegeneration in living humans.'], ['The contribution of neurodegenerative disease to this risk remains controversial.'], ['The objective of this study was to investigate the association between type 2 diabetes and markers of brain aging on magnetic resonance images, including infarcts, lacunes, and white matter hyperintensities as markers of vascular damage and general and hippocampal atrophy as markers of neurodegeneration in Japanese-American men born between 1900 and 1919 and followed since 1965 in the Honolulu-Asia Aging Study.'], ['There is an increasing interest in how oxidative stress can cause cells to go into apoptosis in both normal ageing and in neurodegenerative disorders.'], ['We evaluated pathomechanisms and systemic manifestations of Alzheimer disease (AD), an aging-related dementing neurodegenerative disorder, by expression profiling.'], ["Attention is focussed on the ROS/RNS-linked pathogenesis of cancer, cardiovascular disease, atherosclerosis, hypertension, ischemia/reperfusion injury, diabetes mellitus, neurodegenerative diseases (Alzheimer's disease and Parkinson's disease), rheumatoid arthritis, and ageing."], ["BACKGROUND: Of the disabling disorders of the elderly, depression is the most common affective disorder and Alzheimer's disease (AD) the most common neurodegenerative disorder."], ["In our previous study, human neural stem cells (HNSCs) transplanted into aged rat brains differentiated into neural cells and significantly improved the cognitive functions of the animals, indicating that HNSCs may be a promising candidate for cell-replacement therapies for neurodegenerative diseases including Alzheimer's disease (AD)."], ['Several human diseases such as neurodegeneration, cancer, aging, retinal dystrophy, and inflammation arise from defects HSPs and protein folding.'], ['RESULTS: AD is a progressive and fatal neurodegenerative disorder characterized by cognitive dysfunctions, particularly in learning and memory, and the emergence of behavioral abnormalities.'], ['Cancer, diabetes, obesity, neurodegeneration, cardiomyopathy and even aging are all associated with mitochondrial dysfunction.'], ['To date, oxidative stress has been implicated in aging or various disorders, including inflammatory or degenerative neurological disorders.'], ['The Human Proteome Organisation Brain Proteome Project aims at coordinating neuroproteomic activities with respect to analysis of development, aging, and evolution in human and mice and at analysing normal aging processes as well as neurodegenerative diseases.'], ['Several lines of evidence suggest that hGSTT1-1 and/or hGSTM1-1 play a role in the deactivation of reactive oxygen species that are likely to be involved in cellular processes of inflammation, ageing and degenerative diseases.'], ['The landmark description of neurofibrillary tangles (NFTs) and senile plaques as the pathological hallmarks of an unusual form of dementia 100 years ago by Alois Alzheimer launched the quest to understand a neurodegenerative disorder that now has become a scourge in the 21st Century due to the unprecedented increase in human life expectancy since 1900.', 'This brief review summarizes insights into mechanisms whereby pathological alterations in tau impair axonal transport resulting in neurodegeneration and how these insights are being exploited now to develop novel therapeutic interventions for the treatment of AD.'], ['The pathology of these and other neurodegenerative disorders, including polyglutamine diseases, is characterised by the presence of inclusion bodies in brain tissue of affected patients.', 'To date, parkin is the only E3 confirmed to have a direct causal role in neurodegenerative disorders.', 'In this review, we will discuss the role(s) of E3s in neurodegenerative disorders.'], ['Presbyosmia has been ascribed to idiopathic causes despite recognition that many neurodegenerative diseases also induce loss of olfactory function and increase in incidence in the aged population.'], ['PURPOSE: Discourse characteristics of adults with right hemisphere brain damage are similar to those reported for healthy older adults, prompting the question of whether changes are due to neurological lesions or normal aging processes.'], ['This article will focus on evidence for anaesthetic toxicity in the central nervous system, which appears to be susceptible to anaesthetic neurotoxicity primarily at the extremes of ages but via different pathways: in the neonate, during the period of most intense synaptogenesis, anaesthetics can induce excessive apoptosis; in the aging brain subtle cognitive dysfunction can persist long after clearance of the drug and processes resembling neurodegenerative disorders may be accelerated.'], ['Increasing our knowledge of this process is not merely of fundamental importance, as mutations of the mitochondrial genome are known to cause a spectrum of clinical disorders and have been implicated in more common neurodegenerative disease and the ageing process.'], ['Children with hereditary severe hyperhomocysteinemia present with a variety of neurological impairment, and mild hyperhomocysteinemia has been associated with neurodegeneration in the elderly.'], ['Although such changes correlate with neuronal atrophy in age-related neurodegenerative disorders and in related models of protein accumulation, the autophagic/lysosomal responses appear to be compensatory reactions.'], ['Oxidative stress has long been suspected to be involved in many disease processes, including carcinogenesis, neurodegeneration and aging, but its mechanisms are largely unknown.'], ['Complex genetic and environmental interactions contribute to abnormal aging and neurodegenerative disorders.', 'Common genetic polymorphisms that affect the response to inflammation and cell injury provide a beginning strategy for dissecting neurodegenerative disorders.', 'The effects of APOE, Hfe, and AAT on glucose, lipid, iron and trace mineral homeostasis may affect normal development and aging of the nervous system in addition to their effects on outcome of toxic environmental and occupational exposures and susceptibility and outcome of neurodegenerative illnesses.'], ['It is also a potent cholinesterase inhibitor and an arylesterase, combating organophosphate poisoning and metabolization of environmental neurotoxins which might be responsible for neurodegeneration with aging.'], ['Conversely, motoneuron groups that appear more resistant to the process of neurodegeneration in ALS (e.g., oculomotor, trochlear, and abducens nuclei) as well as the cerebellum receive only sparse 5-HT input.'], ["Such attrition of the brain's immune system could contribute to the development of neurodegenerative disease by diminishing glial neuroprotection."], ['Research in the brain sciences now holds the promise of therapies that halt and even reverse neurodegeneration, of better diagnostic tools, neural prostheses for the paralysed and drugs for depression and anxiety that are tailored to the individual, thereby eliminating or reducing side effects.'], ['BACKGROUND: Parkinson disease (PD) is primarily a neurodegenerative disorder that affects as many as 1,500,000 people in the United States.'], ['Moreover, transdermal dopaminergic drugs, particularly rotigotine, seem the ideal treatment for patients experiencing restless legs syndrome or periodic limb movement disorder during sleep, disorders that are quite common in elderly people or in association with neurodegenerative diseases.'], ['BACKGROUND AND PURPOSE: Rapid eye movement (REM) sleep behavior disorder (RBD) has a known association with other medical conditions, including narcolepsy and neurodegenerative diseases such as synuclienopathies.'], ["Mitochondrial defects in neurodegenerative diseases include Parkinson's, Alzheimer's and Huntington's disease."], ['Systems biology offers enormous potential to understand the complexity of human brain aging and neurodegenerative diseases.', 'As protocols and methods for improved quantitative high-throughput proteomics constantly improve, this approach will likely continue to provide deeper insight into human brain aging and neurodegenerative diseases.'], ['Unravelling these distinct contributions to the aged phenotype will be critical to the success of any therapeutic application of stem cells in the emerging field of regenerative medicine with respect to tissue injury, degenerative diseases or normal functional declines that accompany ageing.'], ['Twenty-five genes in common with those identified in aging kidneys and several genes involved in neurodegenerative diseases were also detected.'], ['Cholinergic neuron function changes with increasing age and are targeted in neurodegenerative diseases such as AD, thus we compared expression and subcellular localization of 69- and 82-kDa ChAT in necropsy brain samples from control subjects of varying ages and from Alzheimer disease (AD) subjects.'], ['Mitochondrial oxidative stress plays important roles in aging and age-related degenerative disorders.'], ['NPC is a fatal juvenile neurodegenerative disorder characterized by premature neuronal death and somatically altered cholesterol metabolism.', 'However, the molecular mechanisms of neurodegeneration in NPC and AD are largely unknown.', 'This review provides a consolidation of work done using U18666A in the past half century and focuses on the implications of our research findings on the mechanism of U18666A-mediated neuronal apoptosis in primary cortical neurons, which may provide an insight to elucidate the mechanisms of neurodegenerative diseases, particularly NPC and AD, where apoptosis might occur through a similar mechanism.'], ['Free radicals have been associated with pathogenesis of various disorders like cancer, diabetes, cardiovascular diseases, autoimmune diseases, neurodegenerative disorders and are implicated in aging.'], ['Consequently, the identification of targets for these proteins is of particular interest for a better understanding of the consequences of AGE-modification in aging, neurodegenerative diseases and diabetes.'], ['These findings also indicate that Reticulon proteins could be considered as new putative drug targets in therapies of neurodegenerative disorders.'], ['This review considers the basic principles of mitochondrial genetics which govern both the behaviour and investigation of pathogenic mtDNA mutations summarizing recent advances in this area, and an assessment of the ongoing debate into the role of somatic mtDNA mutations in neurodegenerative disease, ageing and cancer.'], ['The pathological expansion of unstable trinucleotide repeats is known to cause neurodegenerative diseases.', 'In this paper we hypothesize the possible role of glutamine deamidation as a signaling event in the pathogenesis of neurodegenerative diseases associated with triplet repeat expansion.'], ['Hypoxia is implicated in aging and neurodegenerative diseases.'], ["In addition to being a common disease requiring treatment, glaucoma is also a model system for other degenerative diseases, and many of the concepts originally developed in relation to neurodegenerative diseases such as Alzheimer's disease are under investigation for glaucoma."], ['Damage to mtDNA is therefore an important contributor to human ageing, cancer and neurodegenerative diseases.'], ['Argyrophilic grain disease (AgD) is a relatively newly described neurodegenerative disease with late-onset dementia.'], ['The demonstration of this study may allow further exploration of the use of siRNA for scientific research and the treatment of disc degenerative diseases.'], ["Alzheimer's disease (AD) is associated with accumulations of amyloid-beta (Abeta) peptides, oxidative damage, mitochondrial dysfunction, neurodegeneration, and dementia."], ['This theory proposed that, because of their high reactivity, reactive oxygen species (ROS) would lead to unavoidable and potentially deleterious by-products, and such an increasingly damaging process could be responsible for degenerative diseases and aging.'], ['Although there is a consistent aging-related upregulation of microglial activation markers in experimental animals and humans that could be interpreted as aging-related neuroinflammation, it is generally difficult to show a direct correlation between ostensible microglial activation and neurodegeneration.', 'The concept of microglial senescence offers a novel perspective on aging-related neurodegeneration, namely that neurodegeneration could also occur secondary to microglial degeneration.'], ['We conclude, based on the previously described heritability of both albumin (h(2) = 0.40) and total cholesterol (h(2) = 0.50) in this population, that underlying genetic factors associated with both chronic degenerative diseases and biological aging may have important implications for understanding mortality patterns in this community.'], ['The second hypothesis proposes that the relationship between deteriorated neighborhood conditions and social relationships will depend upon whether older study participants have strong social skills.'], ['The occurrence of degenerative spinal disease subsequent to dystonic movement disorders has been neglected and has received more attention only recently.', 'To characterize better the particular features of degenerative spinal disease in patients with dystonia and to analyze operative strategies, we reviewed the available published data.', 'Epidemiologic studies reveal that degenerative spinal disorders in patients with dystonia and choreoathetosis occur much earlier than in the physiological aging process.'], ['Increasing evidence demonstrates that oxidative stress causes damage to cell function with aging and is involved in a number of age-related disorders including atherosclerosis, arthritis, and neurodegenerative disorders.'], ['No significant correlation was observed between lower back pain and radiographic evidence of degenerative spinal disease.'], ['Everyone ages, but only some will develop a neurodegenerative disorder in the process.', 'Emerging evidence on protein interaction networks that monitor and respond to the normal ageing process suggests that successful neural ageing is possible for most people, but also cautions that cures for neurodegenerative disorders are unlikely in the near future.'], ['Participants reported no clinical symptoms relating to dysphagia, neurological impairments, or degenerative diseases.'], ['Repair in degenerative disease seems to be feasible, with good long-term results.'], ["Based on the fact that Alzheimer's disease is a progressive neurodegenerative disorder that is characterised by cognitive impairment, and that neuroinflammation is now recognised as a prominent feature in Alzheimer's pathology, we have concluded that targeting PDE4 with selective inhibitors may offer a novel therapy aimed at slowing progression, prevention and, eventually, therapy of Alzheimer's disease."], ['RESULTS: The following diagnoses were established: widened perivascular spaces in 11 cases, foci most probably associated with brain aging -21, with migraine -15, ischaemic changes -52, vasculitis -12, hypoxic-ischaemic changes -8, haemorrhagic foci -11, inflammatory changes -20, multiple sclerosis -50, central pontine and extrapontine myelinolysis -7, metastases -7, changes caused by radio-and chemotherapy - 8, lesions associated with neurometabolic diseases - 10, CNS degenerative diseases - 13, eclampsia - 1.'], ['Neurodegeneration involving both motor and nonmotor systems may be associated with weight loss in PD.'], ['Argyrophilic grain disease (AGD) is a progressive degenerative disease of the human brain, the prevalence of which increases with advancing age.'], ['There is now strong evidence implicating the generation of reactive oxygen species (ROS) and the corresponding response to oxidative stress as key factors in the pathogenesis of several human diseases including cancer, atherosclerosis, and neurodegenerative disorders, and in ageing.'], ["Alzheimer's disease (AD) is a progressive neurodegenerative disorder whose clinical manifestations appear in old age.", 'In this review, we present evidence for the developmental basis of neurodegeneration and discuss mechanisms that may explain how perturbations during development can have long-term or delayed consequences in the aging brain.'], ["OBJECTIVES: Primitive reflexes (PR) generally disappear early in life but may reappear later, in which case they are often associated with chronic neurological conditions, such as dementia or Parkinson's disease."], ['In this review, we describe the features of brain aging and age-associated neurodegeneration in a small lemurian primate, the Microcebus murinus, also referred to as the mouse lemur.', 'Among elderly mouse lemurs, the majority show normal brain aging, whereas approximately 20% develop neurodegeneration.', 'This Microcebus age-associated neurodegeneration is characterized by a massive brain atrophy, abundant amyloid plaques, a cytoskeletal Tau pathology and a loss of cholinergic neurons.', 'While elderly mouse lemurs with normal brain aging maintain memory function and social interaction, animals with age-associated neurodegeneration lose their cognitive and social capacities and demonstrate certain similarities with age-associated human AD.', 'We conclude that M. murinus is an interesting primate model for the study of normal brain aging and the biochemical dysfunctions occurring in age-associated neurodegeneration.'], ['Lesion studies suggest that respiratory cell death might explain morbidity and mortality associated with neurodegenerative disorders and ageing.'], ['Further, patterns of AD pathology correlate with regions of lower Pin1 expression in normal human brain; Pin1 knockout mice suffer neurodegeneration; and Pin1 can ameliorate p-tau pathology by isomerizing p-tau, facilitating its trans-specific dephosphorylation and restoring its ability to bind to and restabilize microtubules and thence cytoskeletal integrity.', 'We also show that Pin1 associates with lipofuscin when lipofuscin accumulations become marked and correlate with susceptibility to neurodegenerative disease.', 'Our data are consistent with the possibility that neuronal Pin1 deficits may be a contributory factor in neurodegeneration associated with aging.'], ["In Alzheimer's disease, multiple pathogenic events, including genetic factors, accumulation of aberrant or misfolded proteins, protofibril formation, ubiquitin-proteasome system dysfunction, excitotoxic reactions, oxidative and nitrosative stress, mitochondrial injury, synaptic failure, altered metal homeostasis, dysfunction of axonal and dendritic transport, and chaperone misoperation may converge in pathogenic pathways leading to premature death and neurodegeneration.", 'Some of these mechanisms are common to several neurodegenerative disorders, which differ depending upon the gene(s) affected and the involvement of specific genetic networks, together with epigenetic factors and environmental events.'], ['Good evidence exists that early nutrition affects key risk factors for chronic degenerative diseases of middle and later life, such as osteoporosis and cardiovascular disease.'], ['Since oxidative stress plays an important role in brain aging, and in many neurodegenerative disorders, to further understand the mechanistic underpinnings of clusterin expression, in this study, we examined clusterin expression in human neuroblastoma cells under conditions of increased production of reactive oxygen species and lipid peroxidation.'], ['Many current drugs increase the average lifespan by preventing fatal diseases or by slowing down the progressive degenerative diseases that increase mortality.'], ['Oxidative stress contributes to the process of aging as well as a variety of chronic degenerative diseases.'], ['In addition, the increasing life expectancy in the Western world raises the social importance and the economical impact of age-related neurodegenerative disorders since the incidence of Alzheimer disease and Parkinson disease is higher in the elderly.'], ["DWI/DTI measure of water diffusion has been proven to be invaluable for the study of many neurodegenerative diseases (e.g., Alzheimer's disease and Creutzfeldt-Jakob disease) that predominantly involve GM."], ['Costs associated with oxygen use are free radical and reactive oxygen metabolite (ROM) formations, which create oxidative stress and contribute to various processes including aging, degenerative diseases and cancer.'], ['Intriguing are the phenotypic similarities between s-IBM muscle fibers and the brains of Alzheimer disease, the most common neurodegenerative disease of older persons.'], ["Accumulation of AGEs is a characteristic feature of the aging brain and contributes to the development of neurodegenerative diseases such as Alzheimer's disease (AD)."], ['Progressive supranuclear palsy (PSP) is a neurodegenerative disorder, which may possibly be induced by oxidative stress.'], ['The human health risks from clinical and animal research studies are reviewed, including aldehydes as haptens in allergenic hypersensitivity diseases, respiratory allergies, and idiosyncratic drug toxicity; the potential carcinogenic risks of the carbonyl body burden; and the toxic effects of aldehydes in liver disease, embryo toxicity/teratogenicity, diabetes/hypertension, sclerosing peritonitis, cerebral ischemia/neurodegenerative diseases, and other aging-associated diseases.'], ['Aside acute focal recurrent inflammation and diffuse chronic neurodegeneration, accelerated ageing-related mechanisms may operate in the central nervous system of multiple sclerosis patients.'], ['The heat shock response contributes to establishing a cytoprotective state in a wide variety of human diseases, including inflammation, cancer, aging and neurodegenerative disorders.', 'Acetylcarnitine is proposed as a therapeutic agent for several neurodegenerative disorders, and there is now evidence that it may play a critical role as modulator of cellular stress response in health and disease states.'], ['Increasing evidence suggests that oxidative damage is associated with normal aging and several neurodegenerative diseases.'], ["In particular, we demonstrate that the age induced alterations of healthy heart rate dynamics asymptotically resemble those in so-called primary autonomic failure with neurogenic SNS dysfunction and in other neurodegenerative disorders, including Parkinson's disease even without known autonomic abnormalities."], ['The complex interplay between inflammatory mediators, ageing, genetic background, and environmental factors may ultimately regulate the outcome of acute CNS injury and progression of chronic neurodegeneration, and be critical for development of effective therapies for CNS diseases.'], ['The adjacent testicular parenchyma was atrophied and the rete testis showed some associated degenerative lesions related to arteriosclerosis.'], ['Age-related degeneration of brain white matter (WM) has received a great deal of attention, with recent studies demonstrating that such changes are correlated with cognitive decline and increased risk for the development of age-related neurodegenerative disease.'], ['Producing these characteristic neuropathological lesions in animals causes progressive neurodegeneration and in some cases similar behavioral disruptions to those seen in AD patients.'], ['Family history of neurodegenerative disease, particularly DAT, were more prevalent among NMCI and converted DAT subjects.'], ['However, higher levels or a broader distribution of PPT1 expression, or both, will be required for more complete correction of this neurodegenerative disease.'], ['Alzheimer disease (AD), an age-related neurodegenerative disorder with progressive loss of memory and deterioration of comprehensive cognition, is characterized by extracellular senile plaques of aggregated beta-amyloid (Abeta), and intracellular neurofibrillary tangles that contain hyperphosphorylated tau protein.'], ['This study aimed to determine the forces required to cause partial or total detachment of a heart valve prosthesis in patients with age-related degenerative diseases exposed to MRI.'], ['Cognitive impairment in normal aging and neurodegenerative diseases is accompanied by altered morphologies on multiple scales.'], ['This shift from efficient to inefficient aggregate clearance could occur with aging, offering an explanation for the age-associated nature of these neurodegenerative diseases.'], ["INTRODUCTION: Reactive oxygen species (ROS) have been implicated in neurodegeneration and seem to be involved in the physiology and pathophysiology of several diseases, including normal aging and Alzheimer's disease (AD)."], ["In addition to the well-documented mood-stabilizing effects of lithium in manic-depressive illness patients, recent in vitro and in vivo studies in rodents and humans have increasingly implicated that lithium can be used in the treatment of acute brain injuries (e.g., ischemia) and chronic neurodegenerative diseases (Alzheimer's disease, Parkinson's disease, tauopathies, and Huntington's disease).", 'Importantly, neurogenesis, that is, birth/maturation of functional new neurons, continues to occur throughout the lifetime in human adult brains (e.g., hippocampus); the neurogenesis is impaired by multiple not-fully defined factors (e.g., aging, chronic stress-induced increase of glucocorticoids, and excitotoxicity), accounting for brain atrophy in patients with depressive illness and neurodegenerative diseases.'], ["In this article, we propose that the Arrhenius rate law has a profound impact on aging and a variety of neurodegenerative disorders including Alzheimer's disease, and we review the supporting evidence.", 'Given the exponential temperature dependency of all biochemical factors, cooler body temperatures may promote longevity and combat neurodegenerative disorders.', 'This promises to offer extraordinary yet unexplored weapons against two formidable enemies of the human body: aging and neurodegenerative disorders.', 'In view of the known rapid progressive neurodegeneration associated with ALS, minute variations in core body temperature may, in fact, demonstrate statistically significant differences in disease progression.'], ["They have been observed to occur more frequently both with normal aging and with neurodegenerative diseases such as Alzheimer's disease (AD)."], ['Losses of working and long-term memory are hallmarks of human aging and may signal impending neurodegenerative disease.'], ["PURPOSE OF REVIEW: The aim of this article is to review the role of immunotherapy in the removal of proteins which accumulate abnormally in neurodegenerative disorders associated with dementia, in particular amyloid-beta accumulation in Alzheimer's disease.", 'Immunotherapy for removal of the proteins which accumulate in other neurodegenerative disorders associated with dementia such as prion proteins and alpha-synuclein are in the early stages of development.'], ['tHcy may potentiate neurotoxic and vasculopathic processes, including amyloid beta protein (Abeta) metabolism, implicated in neurodegenerative diseases.'], ['However, certain oxidized proteins are poorly handled by cells, and together with possible alterations in the rate of production of oxidized proteins, may contribute to the observed accumulation and damaging actions of oxidized proteins during ageing and in pathologies such as diabetes, arteriosclerosis and neurodegenerative diseases.'], ["Age-related changes in hippocampal regions also may be harbingers of more severe decrements to come from neurodegenerative disorders such as Alzheimer's disease (AD)."], ['With life expectancy increasing continuously, the effects of neurodegeneration on brain function are a topic of ever increasing importance.', "Specifically, in order to elucidate whether brain-activation patterns in Alzheimer's disease (AD) and in healthy aging follow general rules in the context of degeneration and compensation, it is necessary to compare functional brain-activation patterns during different states of neurodegeneration.", 'This article integrates the findings of functional activation studies at different stages of neurodegeneration: in healthy aging, in subjects at high risk of developing dementia, in subjects with mild cognitive impairment (MCI), and in patients suffering from AD.'], ["Neural transplantation of the stem cells are already applied to clinical trials for many degenerative neurological diseases, including Huntington\\'s disease, Parkinson\\'s disease, and strokes."], ['Modern stereological techniques offer a more rigorous approach for quantifying neuropathological changes associated with aging and degenerative disease.'], ['These mutations may contribute to changes in brain function during normal aging and neurodegenerative disorders.'], ['The interleukin-1 (IL-1) pro-inflammatory cytokine family participates in inflammatory processes and vessel damage involved in neurodegeneration.'], ['The role sirtuins may play in modifying and protecting neurons in patients with neurodegenerative diseases is still unknown.', "However, a recent report of Huntington's disease revealed that Sirtuin protects neurons in a Huntington's disease mouse model, suggesting that sirtuins may protect neurons in patients with neurodegenerative diseases, such as AD."], ['The high incidence of age-related diseases in the increasing population of elderly people has stimulated interest in the search for protective agents that have the capability of preventing premature aging and delaying the onset of degenerative disorders.'], ['Implications for neuroeconomics and neurodegenerative diseases are discussed.'], ["Defective insulin receptor signalings are associated with the dementia in normal aging and patients with age-related neurodegenerative diseases (e.g., Alzheimer's disease); the cognitive impairment can be reversed with systemic administration of insulin in the euglycemic condition."], ['Somatic mutations of mitochondrial DNA have been detected in various pathologies such as cancer, neurodegenerative diseases, cardiac disorders and aging in general.'], ['Osteoarthritis (OA) is a chronic degenerative disorder of multifactorial etiology characterized by loss of articular cartilage and periarticular bone remodelling.'], ['The cumulative results tend to favor the reimplantation technique in terms of longevity of the reconstruction, particularly in congenital degenerative disorders of the aortic wall, whereas remodeling appears to exhibit a more physiologic behavior of the reconstructed valve and re-suspension serves as a simplified approach particularly in acute type A dissection.'], ['Mutations in mitochondrial DNA (mtDNA) are involved in a variety of pathologies, including cancer and neurodegenerative diseases, as well as in aging.'], ['OBJECTIVE: Since mitochondrial DNA (mtDNA) mutations have been established to associate with the aging process and some degenerative diseases, we investigated the correlation between idiopathic osteoarthritis (OA) and the 4977-bp mtDNA deletion.'], ['On one hand, reduced IGF-I activity is associated with significant morbidity in adulthood with an increased risk of developing cardiovascular disease, diabetes, osteoporosis and neurodegenerative diseases.'], ['These diverse functions of presenilins in cortical development and function and neuronal survival have important implications for the pathogenesis of neurodegenerative dementia.'], ["Parkinson's disease is a progressive neurodegenerative disorder caused by the loss of midbrain dopaminergic neurons."], ['Parkinson disease (PD) and Alzheimer disease (AD), the two most common neurodegenerative disorders in American adults, are of purely genetic origin in a minority of cases and appear in most instances to arise through interactions among genetic and environmental factors.', 'In this article we hypothesize that environmental exposures in early life may be of particular etiologic importance and review evidence for the early environmental origins of neurodegeneration.'], ['The search for effective treatments that prevent oxidative stress associated with premature ageing and neurodegenerative diseases is an important area of neurochemical research.'], ['Nonetheless, and since humans not only are the longest-lived primate but feature the largest brain, one hypothesis is that a gradual optimization of the human mitochondrion occurred in the hominid lineage driven by the need to optimize the aerobic energy metabolism to delay neurodegeneration.'], ['Finally, we propose that neuroactive hormone therapy may provide significant improvement in some cognitive deficits in all stages of human life and in cases of neurodegenerative diseases.'], ["BACKGROUND AND AIMS: Parkinson's disease (PD) is one of the most frequent neurodegenerative disorders characterized by bradykinesia, tremor at rest, and rigidity."], ['The mechanism of neurodegeneration caused by beta-amyloid in Alzheimer disease is controversial.'], ['Because disturbances in intracellular transport and protein secretion mechanisms are associated with a number of ageing-associated neurodegenerative diseases, cell-permeable PEP inhibitors may be useful for the application in a variety of related clinical conditions.'], ['Dementia with Lewy bodies (DLB) is the second most common cause of neurodegenerative dementia in older people that has only been recognized in the past decade and that remains widely underdiagnosed.'], ["Interest in inhibitors of monoamine oxidase type B (MAO B) has grown in recent years, due to their therapeutic potential in aging-related neurodegenerative diseases, such as Parkinson's disease and Alzheimer's disease."], ['Moreover, we have found that this pathology can be reduced by controlling the activity of an endogenous calpain inhibitor known as calpastatin, providing a possible approach for the treatment of diverse neurodegenerative disorders, including AD.'], ['It has been shown that apo E increased the production of nitric oxide (NO) from human monocyte-derived macrophages (MDM); this effect could represent an important link between tissue redox balance and inflammation, since inflammation and oxidative stress are involved in chronic neurodegenerative disorders.'], ['Understanding the effects of aging on gene expression in the human brain is of particular interest, because of its relation to both normal and pathological neurodegeneration.', 'These results demonstrate the diversity of aging patterns present within the human brain, as well as how rapidly genome-wide patterns of aging can evolve between species; they may also have implications for the oxidative free radical theory of aging, and help to improve our understanding of human neurodegenerative diseases.'], ['Increased PLD activities in acute and chronic neurodegeneration as well as in inflammatory processes are evidently due to astrogliosis and may be associated with protective responses of tissue repair and remodeling.'], ['Several major diseases of old age, including atherosclerosis, macular degeneration and neurodegenerative diseases are associated with the intracellular accumulation of substances that impair cellular function and viability.'], ['DM1 has been suspected to be due to premature aging, that is known to be sustained by increased free radicals levels and/or decreased antioxidants activities in neurodegenerative disorders.'], ['Ageing and neurodegenerative conditions are often associated with proteasome dysfunction, possibly mediated by zinc and/or copper ions.', "Studies have shown that (i) the olfactory lobe is normally enriched in carnosine and zinc, (ii) carnosine can suppress copper and zinc toxicity in olfactory neurones, (iii) olfactory dysfunction is often associated with neurodegenerative conditions and (iv) elevated levels of zinc are found in brains of Alzheimer's patients.", 'It is suggested that nasal administration of carnosine should be explored as a possible way of suppressing zinc/copper-mediated proteasome inhibition and consequent neurodegeneration.'], ['Mitochondrial ROS mutates the mtDNA and mtDNA mutations have been associated with a wide range of age-related diseases including neurodegenerative diseases, cardiomyopathy, diabetes and various cancers.'], ['For example, intermittent fasting results in increased production of brain-derived neurotrophic factor (BDNF), which increases the resistance of neurons in the brain to dysfunction and degeneration in animal models of neurodegenerative disorders; BDNF signaling may also mediate beneficial effects of intermittent fasting on glucose regulation and cardiovascular function.'], ['BMSC were obtained from patients undergoing primary total hip arthroplasty for end-stage degenerative joint disease.'], ['Chronic and degenerative disease, including CVD and joint problems, were a source of substantial morbidity among the studied communities.'], ['Furthermore, recently, AGE-their receptor (RAGE) interaction was also involved in neurodegenerative diseases, melanoma growth, expansion and metastasis.'], ['These results raise the possibility of stimulation of inherent precursor cells of aged individuals or AD patients to replace neurons lost in aging and/or neurodegeneration.'], ['OBJECTIVE: Although epidemiological and clinical studies suggest that hormone replacement therapy (HRT) may protect against cognitive disorders and neurodegenerative diseases, the relation between estrogen and cognition in postmenopausal women remains controversial.'], ['Mitochondrial dysfunctions have been implicated in the pathophysiology of several age-related diseases including age-related macular degeneration (AMD), a progressive neurodegenerative disease affecting primarily the retinal pigment epithelium (RPE).'], ['CONCLUSIONS: Despite the paucity of human research, basic animal models and clinical data overwhelmingly support the notion that exercise treatment is a major protective factor against neurodegeneration of varied etiologies.', "We conclude that people prone to chronic distress, brain ischemia, brain trauma, and the aged are at increased risk for neurodegenerative diseases such as Alzheimer's."], ["Age- related neurodegenerative diseases, especially Alzheimer's disease (AD), are an important health problem globally.", 'This review discusses the role of reactive oxygen and nitrogen species in the pathogenesis of AD and examines the relevance of antioxidant therapy in altering and/or inhibiting neurodegeneration associated with the disease.'], ["It has recently become clear that AGEs also influence physiological aging and neurodegenerative diseases such as Alzheimer's disease (AD) and amyotrophic lateral sclerosis (ALS)."], ['Disruption of telomere maintenance and/or telomerase expression contributes to the etiology of some degenerative diseases and may participate in the process of aging.'], ['Although vascular lesions and white matter changes can explain the cognitive disorders seen in stroke patients, an underlying neurodegenerative disorder may contribute to the development of PSD.'], ['Importantly, there is increasing recognition that fundamental processes involved in prion propagation--seeded aggregation of misfolded host proteins--are of far wider significance, not least in understanding the commoner neurodegenerative diseases that pose such a major and increasing challenge for healthcare in an ageing population.'], ['Deficiency in complex I function has been associated with various human diseases including neurodegenerative diseases and the aging process.'], ['This study stresses the importance of analyzing early phase BOLD responses and not only using one model of the BOLD response in neurodegenerative diseases.'], ["Increased modification and crosslinking of proteins by advanced glycation end products (AGEs) is a characteristic feature of aging, and contributes to the formation of many of the lesions of neurodegenerative diseases including neurofibrillary tangles and amyloid plaques in Alzheimer's disease."], ['Participants reported no clinical symptoms relating to dysphagia, neurologic impairments, or degenerative diseases, and were asked to swallow 10 ml of barium sulfate solution (10% w/v) three times.'], ['Actual fields of research in neurobiology are not only aimed at understanding the different aspects of brain aging but also at developing strategies useful to preserve brain compensatory capacity and to prevent the onset of neurodegenerative diseases.', 'The scientific debate on the role of zinc and of some zinc-binding proteins in aging and neurodegenerative disorders, as well as on the beneficial effect of zinc supplementation in aged brain and neurodegeneration, is extensively discussed in this review.'], ['The aim of the present work is to study whether the circulating SSAO is also altered in this neurodegenerative disease.'], ['Argyrophilic grain disease (AGD) constitutes a neurodegenerative disorder that occurs in the brains of the elderly and affects 5% of all patients with dementia.'], ['While the superoxide radical and SOD have been implicated in many disease states including inflammatory diseases, diseases of ischemia and reperfusion, neurodegenerative diseases, and cancer, as well as more subtle roles in cell signaling and perhaps in immune function, SOD is not yet in widespread usage in human clinical medicine.'], ['Pharmacoepidemiological data, analytical data from human tissue and body fluids, and mechanistic data mostly from murine models all have implicated oxidation products of two fatty acids, arachidonic acid (AA) and docosahexaenoic acid (DHA), in the pathogenesis of neurodegeneration.', 'Here we review the biochemistry of AA and DHA oxidation, both enzyme-catalyzed and free radical mediated, and summarize those studies that have investigated these oxidation products as effectors of neurodegeneration and biomarkers of AD.', 'Given the evolving appreciation for toxicity associated with current pharmaceuticals used to block AA and DHA oxidation, we close by speculating on likely areas of future research directed at suppressing this facet of neurodegeneration.'], ['Although accumulating evidence from basic science studies using animal models suggests that estradiol plays a critical neuroprotective role against multiple types of neurodegenerative diseases and injuries, recent clinical studies have reported either inconclusive or untoward effects of hormone therapy on the brain.'], ['These findings suggest that microglial cells become increasingly dysfunctional with advancing age and that a loss of microglial cell function may involve a loss of neuroprotective properties that could contribute to the development of aging-related neurodegeneration.'], ['Oxidative stress is thought to play an important role in the initiation and progression of renal, cardiovascular, neoplastic, and neurodegenerative diseases.'], ['Neuronal death progresses over the entire lifespan but manifests clinically in late adulthood, resembling the course of a slow neurodegenerative disorder.'], ['While meat intake has been related to increased risk for a variety of chronic diseases, an abundant consumption of vegetables, fruits, cereals, nuts, and legumes all have been independently related with a lower risk for several chronic degenerative diseases, such as ischemic heart disease, diabetes, obesity, and many cancers.'], ['Furthermore, it is possible that the development of disruptive behaviors and psychosis, in MCI subjects with no previous history of psychiatric illness, constitutes a strong indication that there is an underlying neurodegenerative disorder.'], ['Nevertheless, several reports support the concept that flavonoid intake inhibits certain biochemical processes of brain aging, and might thus prevent to some extent the decline of cognitive functions with aging as well as the development or the course of neurodegenerative diseases.'], ['PD is a progressive neurodegenerative disorder affecting an estimated 78,000 Australians.'], ["Protein aggregation can be secondary to external insults or aging, however, inherited forms of neurodegenerative diseases, such as familial Parkinson's, Huntington's or familial Alzheimer's disease, are directly linked to the mutant proteins aggregation."], ['The hypothesis that neurotoxins may play a role in neurodegenerative disorders remains an elusive one, given that epidemiologic studies often provide conflicting results.', 'Although these conflicting results may result from methodological differences within and between studies, the complexity of chemical disruption of the central nervous system cannot be ignored in attempts to evaluate this hypothesis in different neurodegenerative disorders.', 'For example, although dose reflects "that amount of chemical transferred to the exposed subject", factors such as time and concentration in the organism, the ability to access the central nervous system, and how a compound reaches the central nervous system (routes of administration) or secondarily affects other organ systems leading to central nervous system disruption are clearly important to the concept of neurotoxic risk in neurodegenerative disorders.', 'Added complexity in the study of neurotoxins in human neurodegeneration is derived from data showing that agents may have additive, potentiating, synergistic, or antagonistic effects.', 'Additional limitations in research design along with the populations and methods that are sued to study neurotoxins in human neurodegenerative disorders often fail to meet other criteria such as linking the severity and onset with duration and exposure level.', 'Therefore, although studies of agents such as MTPT provide compelling models of neurotoxins and neurodegeneration in humans, disorders such as ALS, PD, and particularly AD will require additional effort if research is to determine the contribution (presence or absence) of neurotoxins to these neurologic disorders.'], ['This is especially true for neurodegenerative disorders, in which the first steps in pathogenesis are often not accessible in human patients.', "We summarize histopathological and biochemical, cognitive and behavioral observations made in heterozygous APP23 mice, thereby emphasizing the model's contribution to clarification of neurodegenerative disease mechanisms."], ['Ataxia-telangiectasia mutated (ATM) is the gene product mutated in ataxia-telangiectasia (A-T), which is an autosomal recessive disorder with symptoms including neurodegeneration, cancer predisposition and premature aging.'], ['The extrapyramidal, frontal lobe, and limbic systems apparently play an important role, to different degrees, in what can be viewed as a multisystem neurodegenerative syndrome clearly different from "aging."'], ['Before this procedure may be applied to patients with neurodegenerative diseases, its feasibility in elderly healthy participants and a possible age effect on the measurement have to be investigated.'], ['The challenge to understand the effects of ageing represents a "new frontier" in research, both to prevent degenerative diseases and to reduce their consequences.'], ['Environmental as well as nutritional factors are now well acknowledged to interact with the individual genetic background for the development of several diseases, including cancer, cardiovascular disease, and neurodegenerative diseases.'], ['It is presently unknown whether these modifications are a consequence of neurodegeneration or play a pathogenetic role.'], ['However, during the 20th century, age, frailty, disability, and chronic degenerative diseases have been decoupled to some extant in the most long-lived human populations.'], ['Sirtuins represent a new class of evolutionary conserved histone deacetylases, originally identified in yeast, that have emerging pathogenetic roles in cancer, diabetes, muscle differentiation, heart failure, neurodegeneration and aging.'], ['We investigated the incidence of PD and other neurodegenerative diseases among 1,001 first-degree relatives of 162 patients with PD and 851 relatives of 147 controls representative of the population of Olmsted County, Minn., USA.', 'Relatives with PD or other neurodegenerative diseases were ascertained using the family study method.'], ['Alzheimer disease (AD) is the most common neurodegenerative disorder in the elderly and is also considered a progeroid genetic syndrome.'], ['However, current approaches do not significantly modify the course of neurodegeneration or of the aging process, and they offer limited and transient benefit to many patients.'], ['This myelin-centered model of the human brain asserts that unique vulnerabilities of myelin, especially late-developed myelin, and the oligodendrocytes that produce it are directly pertinent to many uniquely human neuropsychiatric diseases including late-life neurodegenerative disorders such as AD.', 'Such treatments can be expected to have a wide spectrum of efficacy and impact multiple human disease processes including potentially slowing brain aging and thus provide opportunities for primary prevention of age-related degenerative disorders such as AD.'], ["We conclude that Cu2+-dependent Abeta-mediated inhibition of COX may be an important contributor to the neurodegeneration process in Alzheimer's disease."], ['Recent evidence indicates that oxidative stress is central to the pathogenesis of a wide variety of degenerative diseases, aging, and cancer.'], ['In summary, carbonyl scavengers might offer a promising therapeutic strategy to reduce the neurotoxicity of reactive carbonyl compounds, providing a potential benefit for patients with age-related neurodegenerative diseases.'], ["Therefore, this brief review aims to summarise existing information on MT expression during CNS ageing, and to examine the possible involvement of this protein in the course of human neurodegenerative disease, as exemplified by Alzheimer's disease."], ["A glia-mediated, inflammatory immune response is an important component of the neuropathophysiology of Alzheimer's disease, of the midlife neurodegeneration of Down's syndrome, and of other age-related neurodegenerative conditions."], ["ApoE4 also accelerates Alzheimer disease pathogenesis in Down's syndrome and many other chronic neurodegenerative conditions, as is well-supported by animal models."], ['Iron accumulates in brain regions associated with neurodegenerative diseases of PD, AD, amyotrophic lateral sclerosis and Huntington disease.'], ['Several neurodegenerative diseases are associated with modifications of Q10 levels.'], ['UNLABELLED: Until recently brain-behavior relationships in healthy ageing and neurodegenerative disease were based on studies of the state of the brain after its final outcome, death.', 'In this talk we will present new data on how this semantic system is affected by healthy ageing, lesions and neurodegenerative disease.', "Neurodegenerative disease: We will contrast two patient groups: Patients with a progressive word finding and semantic memory deficit (primary progressive aphasia, most often due to frontotemporal degeneration) and patients with an isolated episodic memory deficit (incipient Alzheimer's disease, mild cognitive impairment)."], ['Stem cells are proposed to provide the potential to cure degenerative diseases and to give important clues regarding human development and aging.'], ['MITOMAP (http://www.MITOMAP.org), a database for the human mitochondrial genome, has grown rapidly in data content over the past several years as interest in the role of mitochondrial DNA (mtDNA) variation in human origins, forensics, degenerative diseases, cancer and aging has increased dramatically.'], ['Estradiol is neuroprotective in animal models of neurodegeneration.'], ['These results may depend on the fact that in AD patients high HC plasma levels (possibly associated with high glycine levels and/or excessive glutamate release) have favored neurodegeneration and, once this pathological process has been triggered off, the plasma HC levels become independent of the "physiological" aging-induced increase of HC plasma levels.'], ['Accumulating evidences indicate that ceramide is closely involved in apoptotic cell death in neurodegenerative disorders and aging.', 'We examined ceramide levels in the cerebrospinal fluid (CSF) or brain tissues from patients with neurodegenerative disorders and the mechanism of how intra- and extracellular ceramide was regulated during neuronal apoptosis.', "We screened the ceramide levels in the CSF of patients with neurodegenerative disorders, and found that ceramide was significantly increased in patients with Alzheimer's disease (AD) than in patients with age-matched amyotrophic lateral sclerosis (ALS) and other neurological controls."], ['Identification of cerebrospinal fluid (CSF) biomarkers of the common age-related neurodegenerative diseases would be of great value to clinicians because of the difficulties in differential diagnoses of these diseases in clinical practice.', 'However, before undertaking a rational approach to CSF protein biomarkers of age-related neurodegeneration, we must first systematically identify CSF proteins and determine whether their levels change with normal aging.', 'These data not only expand substantially our current knowledge regarding human CSF proteins, but also supply the necessary information to appropriately interpret protein biomarkers of age-related neurodegenerative diseases.'], ['Progesterone, testosterone and estradiol prevent neuronal loss in the central nervous system in different experimental animal models of neurodegeneration.'], ['RESULTS: Neuropsychological and neuropathological correlations thus far suggest that there are centenarians who demonstrate no evidence of neurodegenerative disease.'], ['Among the neurodegenerative diseases associated with ageing, amyotrophic lateral sclerosis (ALS) remains the most devastating.'], ['Unsteadiness of somato-sensory or proprioception is common in the elderly so is degenerative disorder of central control in brain.'], ['On the other hand, experiments in cell culture indicate that NM can activate microglia, eliciting the release of cytotoxic factors that can induce neurodegeneration.'], ['Mitochondrial dysfunction associated with mutant mitochondrial DNA (mtDNA) has been suggested in bipolar disorder, and comorbidity with neurodegenerative diseases was often noted.'], ['We had in view the effect of the oxidative aggression as determinant factor in atherogenic process associated with degenerative psychoorganic disturbances.', 'It was studied a group of old people distributed in two subgroups: a) 51 old people with atherosclerosis (AS) and b) 57 old people with atherosclerosis associated with degenerative psychoorganic disturbances determined by chronic ethylism.', 'The obtained results emphasize an important aggression exerted by the lipid peroxides against the old people organism, aggression that is amplified by the chronic ethylism with appearance of the degenerative psychoorganic disturbances.', 'Generally, the antioxidant defense capacity of the old people organism is depressed, especially in the group with atherosclerosis associated with degenerative psychoorganic disturbances engendered by excessive and chronic alcohol intake.'], ['Degenerative diseases and aging may be manifestations of a decreased capacity to maintain adequate ubiquinol levels.'], ['Molecular chaperones, because of their properties in protein quality control, afford conformational flexibility to proteins and serve to integrate stress-signaling events that influence aging and a range of diseases including cancer, cystic fibrosis, amyloidoses, and neurodegenerative diseases.'], ["Alzheimer's disease is a neurodegenerative disorder associated with aging and cognitive decline."], ["Alzheimer's disease (AD) is a progressive neurodegenerative illness and the most frequent cause of dementia in the elderly."], ['Thus, functional polymorphisms at the genes encoding inflammatory proteins could influence the overall risk of developing these neurodegenerative disorders.'], ["Although visual hallucinations in the elderly are often associated with dementia with Lewy body (DLB), Alzheimer's disease and delirium, they are excluded from the diagnosis of typical CBS, as are cognitive or psychiatric disturbances, sleep disorders and focal neurological lesions."], ['To clarify the significance of Lewy body (LB)-related alpha-synucleinopathy in aging and various neurodegenerative disorders, its incidence and topographic pattern were examined in 260 brains of elderly patients, including 116 autopsy-proven cases of Alzheimer disease (AD), 71 cases of clinically and autopsy-proven Parkinson disease (PD), 38 of dementia with Lewy bodies (DLB), 8 patients with progressive supranuclear palsy (PSP), one with senile tremor, and 26 age-matched controls without neuropsychiatric disorders.', 'However, the basic mechanisms of LB-related AS-pathology and their pathogenic and clinical relevance in aged brain and neurodegenerative disorders await further elucidation.'], ['Based on precedents set by studies of other age-related degenerative diseases, we have focused our laboratory work on senescence as the cause of age-dependent decline in chondrocytes and on the impact of excessive mechanical stresses in promoting senescence.'], ['INCL leads to retinal blindness, neurodegeneration, and early death.'], ['Transcript profiling of the brains of the Cln5-/- mice revealed altered expression in several genes involved in neurodegeneration, as well as in defense and immune response, typical of age-associated changes in the CNS.', 'In general, the progressive pathology of the Cln5-/- brain mimics the symptoms of the corresponding neurodegenerative disorder in man.'], ['The number of cases with degenerative spinal diseases comprised 78.2% of the total number of spine surgery cases.'], ['In recent years, the role of selenium in the prevention of a number of degenerative conditions including cancer, inflammatory diseases, thyroid function, cardiovascular disease, neurological diseases, aging, infertility, and infections, has been established by laboratory experiments, clinical trials, and epidemiological data.'], ["Although current research on brain aging is dominated by Alzheimer's disease (AD), many other brain changes arise during middle age in humans and in rodent models that are independent of AD-like neurodegeneration.", 'Mice are valuable models for these aspects of aging because most genotypes show little neurodegeneration, and none accumulate beta-amyloid unless human transgenes are introduced.'], ['Neuropsychological and neuropathological correlations thus far suggest that there are centenarians who demonstrate no evidence of neurodegenerative disease.'], ['To identify gene expression related to neurodegeneration, beside the presence of amyloid deposition, we used control brains with abundant amyloid plaques, derived from cognitively normal elderly subjects.', 'This protein, which is highly inducible by both type I and type II interferons, was not previously associated with the neurodegenerative disease.'], ['Oxidative damage to DNA may play an important role in both normal ageing and in neurodegenerative diseases.'], ['BACKGROUND AND PURPOSE: It has been shown that heterogeneity of cerebral glucose metabolism is increased in neuropsychiatric degenerative diseases.'], ['Accumulating evidence suggest that oxidative stress resulting in reactive oxygen species generation and inflammation play a pivotal role in neurodegenerative diseases, supporting the implementation of radical scavengers, transition metal (e.g., iron and copper) chelators, and nonvitamin natural antioxidant polyphenols in the clinic.', "As a consequence, green tea polyphenols are now being considered as therapeutic agents in well controlled epidemiological studies, aimed to alter brain aging processes and to serve as possible neuroprotective agents in progressive neurodegenerative disorders such as Parkinson's and Alzheimer's diseases."], ['The cholinergic systems have roles in various neurophysiologic functions, such as learning, memory, and cognition, whereas normal aging and neurodegenerative diseases have been associated with changes in nAChRs.'], ['Recent studies have shown that the heat shock response contributes to establishing a cytoprotective state in a wide variety of human diseases, including ischemia and reperfusion damage, inflammation, cancer, as well as metabolic and neurodegenerative disorders.', 'Particularly, manipulation of endogenous cellular defense mechanisms, via the heat shock response, through nutritional antioxidants or pharmacological compounds, may represent an innovative approach to therapeutic intervention in diseases causing tissue damage, such as neurodegeneration.'], ['The protease has proposed physiological roles in antigen presentation by the MHC class II system, in the biogenesis of the vasoconstrictor peptide endothelin, and in neurodegeneration associated with brain ischemia and aging.'], ['BACKGROUND: Frontotemporal dementia (FTD) is a neurodegenerative disease with early symptoms of personality change and/or language disorder.'], ["Its acronym recalls the basic discovery (Murakami et al., 2000) from which drug(s) will hopefully be developed that are useful for neuroprotection and repair in conditions such as post-traumatic and postischemic lesions, as well as defects proper to normal aging and neurodegenerative diseases, that is, principally Alzheimer's disease."], ['By analogy to neurodegenerative disorders, one could refer to osteoarthritis as the "M. Alzheimer" of articular cartilage.'], ["Rather than tell clinicians and patients what they might expect today from yesterday's procedure, this chapter surveys the role of joint replacement in the treatment of degenerative disease, assesses the associated fiscal burden on society and notes the significant gaps in our current knowledge."], ['The advanced stage of the glycation process (one of the post-translational modifications of proteins) leads to the formation of advanced glycation end-products (AGEs) and plays an important role in the pathogenesis of angiopathy in diabetic patients, in aging, and in neurodegenerative diseases.'], ['Because many degenerative disorders are age related, deteriorating immunity in aging patients might impose additional risk.', 'If widely cross-reactive, the agonist might effectively counteract a variety of neurodegenerative disorders.'], ['CONCLUSION: It is possible that the TNF -308 A allele is maintained during aging because subjects who are heterozygous for this polymorphism possess the optimal inflammatory response with regard to protection against age-related neurodegeneration.'], ['INTERPRETATION: Total joint replacement is an acceptable treatment for degenerative joint disease in alkaptonuric patients, with implant survival comparable to that found in patients with osteoarthritis.'], ["Recent evidence suggests that mitochondria are closely linked with the aging process and degenerative disorders such as Alzheimer's disease and Parkinson's disease."], ['Abnormal proteinaceous deposits are found in the brain of patients with many different neurodegenerative diseases.'], ["BACKGROUND: Alzheimer's disease (AD), a progressive degenerative disorder of the brain, is the most common cause of cognitive impairment in the elderly.", 'With the use of ChEI and NMDA-receptor antagonist therapy, the symptoms and outcomes of this devastating neurodegenerative disease can be improved and its course altered.'], ['Recent studies have shown elevated plasma concentrations of 24-hydroxycholesterol in patients with AD and vascular dementia, suggesting increased brain cholesterol turnover during neurodegeneration.'], ['There is increasing awareness of the role of genetics as a factor that can dramatically alter susceptibility to all disease, especially environmentally induced chronic disease, such as cancer, asthma, diabetes, cardiovascular disease, and neurodegenerative disorders.'], ['BACKGROUND: Abnormal interactions of copper or iron in the brain with metal-binding proteins (such as amyloid-beta peptide [Abeta] or neuromelanin) that lead to oxidative stress have emerged as important potential mechanisms in brain ageing and neurodegenerative disorders.', 'The therapeutic significance of metal dysregulation in neurodegenerative disorders has remained difficult to test.', ': The experimental and transgenic-animal studies of metal-protein interactions are convincing but do not provide conclusive answers either about causality or whether this strategy will protect against neurodegeneration in human beings.', 'The development of optimal second-generation MPACs is a desirable goal and may permit greater insights into the significance of metal-protein interactions across several neurodegenerative disorders.'], ['These results raise the possibility that HIV-related brain inflammation disturbs neuronal protein turnover through the ubiquitin-proteasome apparatus, and might increase the prevalence of age-associated neurodegenerative diseases by decreasing synaptic protein turnover through the proteasome.'], ["The second generation of therapeutic strategies for Alzheimer's disease (AD) embraces the Amyloid Hypothesis, which asserts that through a series of events not completely understood, misfolding of the amyloid-beta (Abeta) peptide is a primary event eliciting neurodegeneration and AD pathology."], ['CPN is not only a degenerative disease, but also has regenerative aspects with a high cell proliferative rate in affected tubules.'], ['We propose that free radicals are critical to cell damage in aged brain and endogenous, and that exogenous antioxidants, therefore, may play effective roles in therapeutic strategies for age-related neurodegenerative disorders.'], ["Alzheimer's disease (AD), the most common form of dementia, is a progressive, degenerative disorder of the central nervous system."], ['Extensive literature demonstrates that aging is accompanied by olfactory loss and hyposmia/anosmia which is also a feature of several neurodegenerative disorders.', 'This review summarizes our present knowledge about the pathological changes in the olfactory system during aging and in various neurodegenerative diseases.'], ['More than 20 syndromes among the significant and increasing number of degenerative diseases of neuronal tissues are known to be associated with diabetes mellitus, increased insulin resistance and obesity, disturbed insulin sensitivity, and excessive or impaired insulin secretion.', 'Discussed in further detail are disturbances of glucose metabolism including impaired glucose tolerance and both insulin-dependent and non-insulin-dependent diabetes caused by neurodegeneration in humans and mice, sometimes accompanied by degeneration of pancreatic beta-cells.', 'Preliminary conclusions suggest that many of the diabetogenic neurodegenerative disorders are related to alterations in oxidative phosphorylation (OXPHOS) and mitochondrial nutrient metabolism, which coincide with aberrant protein precipitation in the majority of affected individuals.'], ["As the alpha4 subunit decreases with ageing and degenerative diseases such as Alzheimer's disease, whereas alpha7 increases in astrocytes in Alzheimer's disease, the findings further indicate the therapeutic relevance of nicotinic agonists such as nicotine."], ["Recent findings suggest the possibility that infectious agents may increase the risk of common age-related neurodegenerative disorders such as Alzheimer's disease (AD) and Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS) and stroke.", 'While scenarios can be envisioned whereby viruses such as Chlamydia pneumoniae, herpes simplex and influenza promote damage to neurons during aging, there is no conclusive evidence for a major role of these pathogens in neurodegenerative disorders.'], ['Local synthesis of PROG in the brain and the neuroprotective and promyelinating effects of this neurosteroid offer interesting therapeutic possibilities for the prevention and treatment of neurodegenerative diseases, for accelerating regenerative processes and for preserving cognitive functions during aging.'], ["Amyloid-imaging agents could also serve as surrogate markers in early diagnosis and neuropathogenesis studies of Alzheimer's disease and other aging-related neurodegenerative disorders."], ["Although dementia is most common, schizophrenia and schizoaffective disorder, delusional disorder, bipolar disorder, and Parkinson's disease, as well as other psychiatric and neurodegenerative disorders, can also occur in this population."], ["These studies highlight the function of H2O2 in processes of learning and memory and their change in elderly individuals, irrespective of neurodegeneration found in Alzheimer's patients."], ['This deficiency in mitochondrial energetic capacity is considered the cause of aging and age-related degenerative diseases.'], ['These results provide the first link between two different macular degenerative disease genes and imply the possibility of a common pathogenic mechanism behind different forms of macular degeneration.'], ['These phosphorylated forms are not only important because of their abundance in aging lenses and the implications for cataract but also because they have been identified in patients with degenerative brain disease.'], ['In the present paper, we have reviewed the principal studies on red cell membrane abnormalities associated with neurodegenerative disorders.', 'We have reviewed the mechanism(s) of the loss of red cell membrane stability and of the precocious red cell aging in neurodegenerative disorders.'], ['Parkinsonism is a symptom of a number of neurodegenerative disorders in the elderly.'], ['OBJECTIVES: To examine the association of chronic degenerative diseases with locomotor activity limitation and social participation among older British women.'], ['Intraneuronal Abeta42 accumulation is also associated with neurodegeneration.'], ['Caloric restriction remains the only intervention known that prevents neurodegeneration of ageing in the ENS, and mechanisms involved in this phenomenon are discussed.'], ['This process has given rise to new health problems, including chronic and degenerative diseases (diseases of affluence).'], ['Recent molecular biology research on neurodegenerative diseases, including parkinsonisms, has identified mutations in the genes that code for the proteins alpha-synuclein and tau, which have been used to classify them into synucleinopathies and tauopathies.'], ['Neurodegenerative diseases are increasingly common in elderly patients, who present a particular anaesthetic challenge.', 'The pathogenesis of neurodegenerative diseases is due to alterations in the transport, degradation and aggregation of proteins.', 'A number of drugs are used in neurodegenerative disorders including antidepressants, benzodiazepines, antipsychotics, acetylcholinesterase inhibitors and levodopa.', 'Levodopa, bromocriptine and tricyclic antidepressants are known to cause orthostatic hypotension in patients with neurodegenerative disease.', "For induction of general anaesthesia propofol is a suitable agent in patients with neurodegenerative disease due to its rapid metabolism, but may not be suitable in patients with Parkinson's disease as it can induce spontaneous involuntary movements."], ["Alzheimer's disease (AD) is a neurodegenerative disorder characterized by the presence in the brain of senile plaques which contain an amyloid core made of beta-amyloid peptide (Abeta)."], ['The search for genetic and environmental factors that determine the fate of neurons during the ageing process has been a widespread approach in the battle against neurodegenerative disorders.', 'In addition, we discuss possible links between these two neurodegenerative disorders.', 'Their imbricate features point to a spectrum of neurodegeneration (tauopathies, synucleinopathies, amyloidopathies) that need further intense investigation to find the missing links.'], ['Previously described associations between low testosterone levels and frontal lobe dysfunction in normal aged men, together with these results, suggest that the hormonal deficiency may act as a "second hit" to impair cognitive function in neurodegenerative disease.'], ['Data from retrospective studies and meta-analyses suggest that elderly patients with high-grade gliomas have a poorer outcome than younger patients, possibly because of the presence of comorbidity, resistance to cancer therapy, genetic aberrations, different histology, neurodegeneration, or age discrimination.'], ['There are currently numerous clinical trials involving administration of antioxidants in a variety of conditions such as coronary heart disease, cataract, cancer and neurodegenerative diseases.'], ['Since platelet glutamate uptake is decreased in neurodegenerative disorders, we performed a morphological and molecular characterization of platelet glutamate transporters.'], ['The presence of Abeta in these extracellular deposits is an additional indication that some of the pathogenic pathways that give rise to drusen and AMD may be shared with other neurodegenerative diseases characterized by misfolded protein deposition and aggregation.'], ['There is strong evidence from basic sciences and epidemiological studies that both estrogens and androgens play a protective role in neurodegeneration.'], ['On the other hand, circulating AGE and tissue deposits mark the course of diabetes mellitus as well as a variety of other vascular or degenerative diseases.'], ['Rapid demographic transition without a concomitant epidemiological transition is responsible for the dual load of infections and degenerative diseases in older persons, these being common causes of death.'], ['Dementia with Lewy bodies (DLB) is the second commonest cause of neurodegenerative dementia in older people.', 'Virtually unrecognised 20 years ago, DLB could within this decade be one of the most treatable neurodegenerative disorders of late life.'], ['A combination of both CAA and AS/LH may, therefore, contribute to neurodegeneration in AD.'], ['In this article, we describe the conceptual basis underlying the use of gene therapy for diseases of the aging nervous system, the principal techniques used for gene delivery, and review preclinical animal studies in 4 different classes of neurologic dysfunction: 1) focal neuronal degeneration in the central nervous system; 2) global neuronal dysfunction in the central nervous system; 3) degenerative disease affecting components of the peripheral nervous system; and 4) intractable focal pain.'], ['Though rare at any particular site, multiple somatic mtDNA mutations induced by oxidative damage or by other mechanisms may accumulate with age in the brain and thus could play a role in aging and neurodegenerative diseases.'], ['(2) Thanks to both a cross sectional and a longitudinal study, the rate of postural stability impairment due to aging was precisely estimated, which will be useful to help distinguishing between the part of postural stability impairment attributable to aging from the one due to neuro-degenerative diseases.'], ['These findings have considerable implications for neuroscience in general, including the study of learning and memory, neural network plasticity, aging, neurodegeneration, and the recovery from brain injury.'], ['Since EDS accompanies many neurological disorders, such as neurodegenerative and neuromuscular diseases, neurologists should be familiar with the diagnosis, its major causes and with treatment options.'], ['In particular, manipulation of endogenous cellular defense mechanisms such as the heat shock response, through nutritional antioxidants or pharmacological compounds, represents an innovative approach to therapeutic intervention in diseases causing tissue damage, such as neurodegeneration.', 'Consistent with this notion, maintenance or recovery of the activity of vitagenes, such as the HO gene, conceivably may delay the aging process and decrease the occurrence of age-related neurodegenerative diseases.'], ['This article reviews the efficacy of the pharmacologic management of psychotic symptoms in primary psychotic disorders, affective disorders, and neurodegenerative disorders.', 'However, the absence of published evidence from RCTs in primary psychotic and affective disorders, and the limited evidence in the neurodegenerative illnesses, is notable.'], ['BACKGROUND: Osteoarthritis is the most common degenerative disease in humans.'], ['BACKGROUND: Parkinson disease (PD) is a neurodegenerative disorder that increases sharply after the sixth decade.'], ['Cervical spondylosis is associated with myelopathy and radiculopathy, which sometimes mimic clinical manifestations of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disorder that affects upper and lower motor neurons.'], ['Inclusion criteria were residence in our long-term care facility; a pain intensity score > 4 on a modified Wong Baker Pain Scale; the patient having prescription orders for one or more of the following drugs: propoxyphene, meperidine, or high dosages of acetaminophen (approaching 4 g/day); suspected neuropathic or mixed nociceptive/neuropathic pain; and/or a diagnosis of diabetes, osteoarthritis, or degenerative joint disease.'], ['A decline in mitochondrial function is well recognized in neurodegenerative diseases and aging, and is thought to play a causal role in their biology.', 'A clue that these new findings are of significance for the pathogenesis of neurodegenerative disease is provided by the observation that OPA-1, a dynamin-related GTPase regulating mitochondrial fusion, is mutated in humans with dominant optic atrophy, which is characterized by degeneration of retinal ganglion cells and childhood blindness.', 'A shift in the rate of mitochondrial fission or fusion may provide a new mechanistic explanation for the mitochondrial dysfunction in neurodegenerative diseases and normal aging, and may offer a new target for therapeutic intervention.'], ["Accumulation of insoluble protein deposits and their cross-linking by AGEs (advanced glycation end products) in the brain is a feature of aging and neurodegeneration, especially in AD (Alzheimer's disease)."], ['PURPOSE: Stem cells, the potentially immortal cells capable of self-renewal, are the focus of research for the ultimate cure for degenerative diseases and the key to the mystery of human development and aging.', 'The therapeutic potential of the differentiated cells can modulate the symptoms of degenerative neurological disorders in animal models.'], ['Our ability to utilise this new knowledge to combat the ravages of the ageing process and its associated illnesses--degenerative diseases and cancers offer much hope for the future.'], ['The issue remains open for older adults without serious degenerative neural disease.'], ['Since decreasing DNA repair has been correlated with increasing age, information available on the effect of dietary calorie restriction on DNA repair potential in different species, including humans, is reviewed with special emphasis on brain in view of its uniqueness and the age related appearance of several neurodegenerative disorders.'], ['They appear to require a consistent period of neurodegeneration in order to emerge.'], ["or intracerebral administrations of PREG-S. Central ACh neurotransmission is known to be involved in the regulation of memory processes and is affected in normal aging and severely altered in human neurodegenerative pathologies like Alzheimer's disease."], ['Besides, mitochondrial DNA (mtDNA) deletion and mtDNA proliferation occur frequently in affected tissues of patients with certain degenerative diseases and during aging of the human.'], ['Special focus is afforded to neurodegenerative disease.'], ['However, the neurobiology of heavy metals is now receiving growing interest, since it has been linked to major neurodegenerative diseases.', 'In the present review some metals that could possibly be involved in neurodegeneration are discussed.', "It is an etiopathogenic factor in diseases related to long-term dialysis treatment, and it has been controversially invoked as an aggravating factor or cofactor in Alzheimer's disease as well as in other neurodegenerative diseases.", 'An increased environmental burden of manganese may have deleterious effects on more sensitive subgroups of the population, with sub-threshold neurodegeneration in the basal ganglia, generating a pre-Parkinsonian condition.', 'In the case of zinc, there has as yet been no evidence that it is involved in the etiology of neurodegenerative diseases in humans.'], ['PATIENT SAMPLE: Twenty-four patients with lumbar degenerative diseases on whom posterior surgeries were performed, with the age ranging from 18 to 85 years.'], ['Genetic mutations affect many phenotypes in flies, worms, rodents, and humans which share several diseases or their equivalents, including cancer, neurodegeneration, and infectious disorders as well as their susceptibility to them.'], ['Numerous lines of evidence place signal transduction cascades at the core of many processes having a direct role in neurodegeneration and associated disorders.'], ['Our data can serve as reference for other studies in humans concerning the etiology of alcoholism or other neurodegenerative diseases with the involvement of tetrahydroisoquinolines.'], ["Proteolytic mechanisms have been implicated in the process of ageing, and in many neurodegenerative disorders such as Alzheimer's, Parkinson's and Huntington's diseases, which are most prevalent in old age.", 'Simple model organisms such as the nematode Caenorhabditis elegans and the fruit fly Drosophila melanogaster, which offer the prowess of sophisticated genetic approaches, have contributed to our understanding of ageing and neurodegeneration.', 'Intensive research in these systems has resulted in detailed models of the ageing process, and also of several neurodegenerative diseases, which recapitulate same aspects of the human pathologies.', 'Evidence from investigations in C. elegans implicates deregulated proteolysis as one major determinant of cellular destruction in neurodegeneration and ageing, and suggests that the process depends critically on the activation of calcium-dependent, calpain proteases and lysosomal aspartyl proteases.'], ['However, it must be stressed that so-called stenotic images (sometimes severe) are present on imaging studies in a great number of symptom-free individuals, and that the relationship between degenerative lesions, importance of abnormal images, and complaints is still unclear.'], ['Amyotrophic lateral sclerosis (ALS), once thought to be a rare neurodegenerative disease, affects between 1.2 and 1.8/100,000 individuals.'], ['While there are many examples of people who live for 100 years or more with little evidence of a decline in brain function, many others are not so fortunate and experience a neurodegenerative disorder, such as Alzheimer disease or Parkinson disease.', 'Although an increasing number of genetic factors that may affect the risk for neurodegenerative disorders are being identified, emerging findings suggest that dietary factors play major roles in determining whether the brain ages successfully or experiences a neurodegenerative disorder.', 'Although additional studies are required in humans, the emerging data suggest that high-calorie diets and elevated homocysteine levels may render the brain vulnerable to age-related neurodegenerative disorders, particularly in persons with a genetic predisposition to such disorders.'], ['A palliative care approach has much to offer people in the advanced stages of neurodegenerative diseases, as well as elderly people dying from diseases other than cancer.'], ['The possibility that prenatal toxin exposure may contribute to the development of a neurodegenerative disease of the aged raises interesting new pathogenic questions and draws attention to the possibility that in utero exposure to neurotoxins may represent a here to fore unrecognized cause of PD.'], ['Ubiquitinated proteinaceous inclusions are the hallmark of many neurodegenerative diseases.'], ['This normal aging process in women is associated with increasing health problems such as osteoporosis, cardiovascular disease, neurodegenerative diseases, and cancer.', "Because estrogens such as the Delta(8)-estrogens are relatively less feminizing than the classical estrogen 17beta-estradiol, they may be important in the development of more neuro-specific estrogens that will be useful in the prevention of neurodegenerative diseases, such as Alzheimer's and Parkinson disease, in both men and women."], ["Parkinson's disease (PD) is a progressive neurodegenerative disease with no known cure and affects approximately 1% of the elderly population."], ['We investigated 31 autopsied brains (3-84-year-olds) without traumatic brain injury and neurodegenerative disease.'], ['GFAP may be used as an additional but not exclusive diagnostic tool in the evaluation of neurodegenerative diseases because its levels change with age and respond to senile plaque and tangle formation.'], ['Increases in COX-2 enzymatic activity and prostaglandin production have been associated with neuronal injury in both acute and age-related degenerative neurological diseases.'], ['Since these hormones act as trophic factors for neurones and glia, it is possible that the decrease in sex steroid levels may contribute to the increased risk of neurodegenerative disorders with advanced age.', 'Sex steroids are neuroprotective in several animal models of central and peripheral neurodegenerative diseases, and clinical data suggest that these hormones may reduce the risk of neural pathology in aged humans.'], ['However, the reciprocal influences of neurones on gene expression in muscle and of muscle on age-related neurodegeneration are poorly understood, and, as a result, interventions aimed at delaying or preventing degeneration of the neural component in aging muscle have been largely unsuccessful.'], ['The incidence of cerebrovascular and degenerative neurologic diseases increase with aging, and these disorders are associated with dysphagia and an impaired cough reflex with the increased likelihood of oropharyngeal aspiration.'], ['Such effects are particularly true in healthy ageing individuals and in those who have neurodegenerative diseases.', 'The ability to use imaging to identify structural brain changes associated with different neurodegenerative disease states would be useful for diagnosis and treatment.', 'These methods use mathematical models sensitive to subtle changes in the size, position, shape, and tissue characteristics of brain structures affected by neurodegenerative diseases.'], ['In most cases of DLB, the distribution of alpha-synuclein pathology and neurodegeneration corresponded to stages 5 and 6 of PD pathology.'], ['Alteration of the mitochondrial proteome and altered mitochondrial function has been implicated in a variety of degenerative diseases, heart disease, aging and cancer.'], ['DNA damage is thought to play a relevant role in degenerative diseases and aging.'], ['Cause and effect links between GSH metabolism and diseases such as cancer, neurodegenerative diseases, cystic fibrosis (CF), HIV, and aging have been shown.'], ["Since chorionic gonadotropin increases secretion of a variety of cytokines by monocytes, and induces their inflammatory reaction and phagocytic activity, high LH levels in aging individuals may also activate microglia (mononuclear phagocyte system in the central nervous system) and contribute to the development of Alzheimer's disease and other inflammation-mediated neurodegenerative diseases."], ['AIM: Mitral valve repair for degenerative disease is widely accepted.', 'We reviewed our recent results with mitral valvuloplasty for degenerative disease with attention to the influence of age.', 'METHODS: Thirty-day results of mitral valvuloplasty for degenerative disease between January 1996 and April 2000 were examined retrospectively.'], ["In the United States, Parkinson's disease is the fourth most common neurodegenerative disorder in the elderly, affecting an estimated half a million people."], ['Several years ago ubiquitin immunocytochemistry first demonstrated that ubiquitin protein conjugates are present in intraneuronal inclusions in all the major human chronic neurodegenerative diseases, as well as in inclusions in cerebellar astrocytomas and in hepatocytes in alcoholic liver disease.', 'Therefore, for the first time we have the opportunity to dissect the substrate of memory and the basis of cognitive decline in aging and in chronic neurodegenerative disease.', 'Clearly, further understanding will provide a platform for novel drug development to treat chronic neurodegenerative diseases, including Alzheimer- and Parkinson-related conditions, and possibly psychiatric disorders.'], ['That means that the society of the future will be a double aging society (more older people who are older than before) with all concomitant burdens of degenerative chronic diseases.'], ["Parkinson's disease (PD) is a progressive neurodegenerative disease that is caused by a loss of neurons in the ventral midbrain."], ['For instance, excesses of apoptosis lead to cell loss that accompanies neurodegenerative diseases, whereas genetically determined defects of apoptosis lead to the deregulated cell proliferation typical of cancer.'], ["Alzheimer's disease (AD) is a genetically complex neurodegenerative disorder and the leading cause of dementia of the elderly."], ['CONTEXT: The importance of early identification of dementia has prompted numerous investigations of mild cognitive impairment and the preclinical stages of progressive degenerative disorders.'], ['These data are consistent with the putative benefits of dietary vitamin C and folate intake and the role of cholesterol in age related neurodegeneration.'], ['BACKGROUND: epidemiological studies have shown that poor early growth is associated with cardiovascular and other degenerative diseases.'], ['Cockayne syndrome (CS) is a genetic human disease with clinical symptoms that include neurodegeneration and premature aging.'], ["It has recently become clear that glycation also affects physiological aging and neurodegenerative diseases such as Alzheimer's disease and amyotrophic lateral sclerosis."], ['Inflammaging is considered the common and most important driving force of age-related pathologies, such as neurodegeneration, atherosclerosis, diabetes and sarcopenia, among others, all of which share an inflammatory pathogenesis.'], ['In addition, the mitochondrial genome seems to be particularly prone to DNA damage and acquired mutations may have a role in ageing, cancer and neurodegeneration.'], ['The role of mitochondria in degenerative diseases is widely recognized.'], ['This suggests that visuospatial impairment may develop as an independent sign of neurodegenerative disease, possibly preceding the clinical onset of AD.'], ['There is strong evidence from basic sciences and epidemiological studies that both estrogens and androgens play a protective role in neurodegeneration.'], ['PON-1 is also an arylesterase that hydrolyzes paraoxon, an active toxic metabolite of parathion, thus providing protection against organophosphate poisoning and metabolization of environmental neurotoxins that might be responsible for neurodegeneration with aging.'], ['Alzheimer disease (AD), a progressive neurodegenerative disorder, is the most common cause of dementia in the elderly.'], ["Alzheimer's disease (AD), a progressive, degenerative disorder of the brain, is believed to be the most common cause of dementia amongst the elderly."], ['However, as far as we know, an immunohistochemical study of intracranial calcification in neurodegenerative diseases has not been performed.'], ["Neurodegenerative disorders such as Alzheimer's disease, Lewy-Body dementia, Parkinson's disease and cerebrovascular dementia result in an insidious cognitive and behavioural decline culminating in the development of severe dementia.", 'The aim of the present paper is to present an overview, in the context of a brain aging continuum, at what stage cognition enhancing and/or neuroprotective intervention strategies aimed at stabilising and/or preventing neurodegenerative disease could demonstrate potential clinical benefit.'], ['These results demonstrate that stimulation of muscarinic receptors provides substantial protection from DNA damage, oxidative stress, and mitochondrial impairment, insults that may be encountered by neurons in development, aging, or neurodegenerative diseases.'], ["The dysregulation in the metabolism of beta-amyloid precursor protein and consequent deposition of amyloid-beta (Abeta) has been envisaged as crucial for the development of neurodegeneration in Alzheimer's disease (AD)."], ['These results may offer a histological correlate of functional imaging studies and are relevant in the context of neurodegenerative diseases such as amyotrophic lateral sclerosis, progressive supranuclear palsy, and Guamanian amyotrophic lateral sclerosis/Parkinsonism-dementia, and in studies of normal brain aging.'], ['Oxidative stress has been postulated to be involved in aging and age-related degenerative diseases.'], ['Controlling DNA damage rate to its possible minimum is likely to have an important impact in preventing cancer and other DNA damage-related degenerative diseases including ageing.'], ["Under this hypothesis, abnormal accumulation of Abeta is followed by a cascade of neurotoxic effects, which eventually result in neurodegeneration and development of Alzheimer's disease."], ['Oxidative damage to mitochondrial DNA has been implicated as a causative factor in a wide variety of degenerative diseases, and in cancer and aging.'], ['However, their etiology is poorly understood and it is unclear whether cerebrovascular changes contribute to functional impairments in the absence of neurodegeneration.'], ['The decedents were long-standing participants in the Honolulu-Asia Aging Study, a prospective epidemiologic investigation of stroke, neurodegenerative diseases, and aging.'], ['Cytokines mediate cellular mechanisms subserving cognition (e.g., cholinergic and dopaminergic pathways) and can modulate neuronal and glial cell function to facilitate neuronal regeneration or neurodegeneration.', "As such, there is a growing appreciation of the role of cytokine-mediated inflammatory processes in neurodegenerative diseases such as Alzheimer's disease and vascular dementia."], ['Although previous studies have suggested an increased activation of humoral immunity in neurodegenerative diseases, it remains unclear whether this phenomenon is secondary to lesion formation or contributes directly to their development.', "Immunocytochemical analyses in human autopsy materials revealed the presence of human Fc fragments as well as Fc receptors only in large pyramidal neurons known to be vulnerable in brain aging and Alzheimer's disease, further supporting a possible role of immunoglobulins in neurodegeneration."], ['PURPOSE: Age-related maculopathy (ARM) and cognitive impairment are both neurodegenerative disorders associated with aging and have been hypothesized to share common pathogenic pathways.'], ['The aim of this review is to summarise the recent findings in the fields of carcinogenesis and neurodegenerative diseases, the both disorders are characterised by the contribution of different factors including the inheritance of mutated genes, and the exposure to endogenous or exogenous agents during the life.', 'The mechanism of apoptosis, that is an excellent strategy in order to eliminate damaged cells, seems to be lost during carcinogenesis, while it seems to be involved in the neuronal death in a lot of neurodegenerative disorders.', 'Pathophysiology of neurodegenerative diseases is complex and likely involves multiple overlapping and perhaps redundant pathways of neuronal damage, characterised by the generation of anomalous proteins, often due to mutations in the corresponding gene, and by their subsequent accumulation into or outside specific areas of the brain.'], ['This unprecedented proportion of the population reaching an old age, or even a very old age (25% of women die after 89 years, and 5% after 95 years) is a novel aspect of human demographics, and represents the very last stage of the epidemiological transition, a term coined to describe the transformation of the prevailing health burden in the population, shifting from infectious and communicable pathologies to chronic and degenerative diseases.', 'As a result, India, like many other developing countries, is facing a double burden of disease, i.e., an upsurge of degenerative diseases while the burden from the old agenda (i.e., malaria, tuberculosis) still reaches devastating proportions in the population.', 'The first will be the absolute increase in the number of older persons, with a corresponding increase in degenerative diseases.'], ['The current report focuses on minimum 10-year results of a proximally hydroxyapatite-coated stem in patients with degenerative joint disease, comparing those 45 years and older (n = 229 hips) with younger patients (n = 41 hips).'], ['The elucidation of the pathways and mechanisms by which apoE-isoform and oxidation affect lipoprotein function in the CNS remains a challenge for scientist in the field of neurodegenerative disease.'], ['Aging is associated with increased risk for neurodegenerative disorders, which can cause significant cognitive and physical impairment and shortened lifespan, thereby causing a burden to society.', 'Diets rich in fruits and vegetables have been shown to improve human well-being and to significantly delay the development of pathologic processes, including neurodegenerative disorders.'], ["Cholinergic neurons of the basal forebrain (BFCN) are selectively vulnerable in neurodegenerative disorders of the elderly, particularly in Alzheimer's disease (AD).", 'The depletion of CB from the BFCN is likely to deprive these neurons of the capacity to buffer high levels of intracellular Ca(2+) and thus to leave them vulnerable to pathological processes, such as those in neurodegenerative disorders, which can cause increased intracellular Ca(2+), thus leading to their degeneration.'], ['Here, we review the types of oxidative damage seen in AD, sites involved, possible origin, relationship to lesions, and compensatory changes, and we also consider other neurodegenerative diseases where oxidative stress has been implicated.', 'Although much data remain to be collected, the broad spectrum of changes found in AD are only seen, albeit to a lesser extent, in normal aging with other neurodegenerative diseases showing distinct spectrums of change.'], ['Smoking has also been shown in some epidemiological studies to be protective against the development of neurodegenerative diseases.', 'Treatment with nicotinic agonists may therefore be useful in both slowing the progression of neurodegenerative illnesses, and improving function in patients with the disease.', 'We will also present hypotheses that might address the mechanisms underlying the ability of nAChR function to protect against neurodegeneration or improve cognition, two potentially distinct actions of nicotine.'], ['Oxidative damage to the mitochondrial DNA is implicated in various degenerative diseases, cancer and aging.', 'The importance of mitochondrial ROS in age-related degenerative diseases is further strengthened by studies using animal models, Caenorhabditis elegans, Drosophila and yeast.'], ["We examined the accuracy of clinical criteria to distinguish Alzheimer's disease (AD) and dementia associated with infarcts of the brain, either isolated (vascular dementia) or associated with degenerative lesions (mixed dementia)."], ['Animal models used to study human aging and neurodegeneration do not display all symptoms of these processes as they are found in humans.'], ['Recent studies show a relationship between oxidants, antioxidants, and degenerative disease of aging like cataract formation.'], ['These data suggest NAA/Cr could be a modest predictor of general cognitive function in both healthy elderly and impaired patients, while MI/Cr is a more specific marker for neuropsychologic dysfunction associated with neurodegenerative disease.'], ['Currently, little is known about the mechanisms responsible for the neuronal degeneration seen during both normal aging and neurodegenerative disease; however, among the prime candidates responsible for producing these effects are free radicals.', 'As a result, this inability provides a fertile environment for the subsequent development of neurodegenerative disease.'], ['Membrane lipid domains have been identified in brain and can be modified by different experimental conditions, aging and certain neurodegenerative diseases.'], ['These results suggest that neurotrophin-responsive nGAPs serve as molecular markers of neuronal plasticity during development and aging, and that the neuronal plasticity decreases, at least in certain neuronal circuits, in the aged brain and neurodegenerative diseases.'], ['Conditions associated with aging, such as congestive heart failure and degenerative neurological conditions become more prominent as reported causes of death in the oldest individuals.'], ["The evidence for OS participation as a cause of PD can be summarized as follows: 1) OS is involved in physiological aging, 2) there is ample evidence that OS is significantly enhanced in PD compared to age-matched healthy persons, 3) OS is an early feature of PD because OS-dependent aggregation of proteins in the form of advanced glycation end products can be imaged in Lewy bodies at a time in a person's life, when no phenotype of a neurodegenerative disorder is evident, 4) Experimental models of PD show OS and degeneration of dopaminergic neurons.", 'The toxin-induced neurodegeneration can be blocked by antioxidants, and 5) Activated microglia, known to release free radicals and inflammatory cytokines, are present in brains of Parkinsonian patients.'], ['Biochemically significant mitochondrial defects do occur in AD and are likely to contribute to the overall central nervous system dysfunction in impairing neuronal function and possibly causing neurodegeneration via mechanisms other than apoptosis.'], ['For this purpose the most appropriate conceptual framework is supplied by a preventive model, broadly similar to those already developed for some other forms of chronic degenerative disease.'], ['Ataxia telangiectasia (AT) is a pleiotropic genetic disorder characterized by progressive neurodegeneration, especially of cerebellar Purkinje cells, immunodeficiency, increased incidence of cancer, and premature aging.'], ["The present review summarizes our current knowledge about the chaperone-deficiency in the aging process, as well as the possible involvement of chaperones in neurodegenerative diseases, such as in Alzheimer's, Parkinson's, Huntington- and prion-related diseases.", 'Chaperone-buffered, silent mutations may be activated during the aging process, which leads to the phenotypic exposure of previously hidden features and might contribute to the onset of polygenic diseases, such as atherosclerosis, cancer, diabetes and several neurodegenerative diseases.'], ['Furthermore, the spatial mismatch between amyloid ss-precursor protein (APP) and tau pathologies in cortical brain areas demonstrates that neurodegeneration is not a direct consequence of extracellular Abeta neurotoxicity.'], ['Argyrophilic grain disease (AGD) is a neurodegenerative disorder of the aged human brain associated with the formation of abnormal tau protein in specific neurones and macroglial cells.'], ['The conditions of particular interest for this review are excessive DNA damage (which potentially leads to cancer), cellular destruction in neurodegenerative diseases and aging itself.'], ["Elevated levels of o,o'-dityrosine have been detected in inflammatory lung disease, neurodegenerative disorders, and aging."], ['This evidence of widespread oxidative damage and Abeta deposition is further justification for using the canine model for studying human brain aging and neurodegenerative diseases.'], ["Alzheimer's disease (AD) is the most usual neurodegenerative disorder leading to dementia in the aged human population."], ['Although these findings apply to cells in general under these two stress conditions, the up-regulation of apoE in particular may be a response to cell injury with implications for neurodegeneration such as that found with late-onset AD.'], ['Degenerative heart disease was seen more frequently in the elderly (22.5% vs 2.7%, P =.003).'], ["The authors examined the hypothesis that the concentration of nerve growth factor is lower than normal in the preclinical phase of neurodegenerative dementia, especially Alzheimer's disease."], ['Osteoarthritis (OA) is a common chronic and progressive degenerative joint condition.'], ['With an aging population and the growing burden of degenerative joint disease, the management of this preventable disease remains at the forefront of surgical care.'], ['Any treatment that could positively modulate central neuropeptides levels would provide a promising therapeutic approach to the treatment of cognitive deficits associated with aging and/or neurodegenerative diseases.'], ['Current recommended dietary allowances for vitamins and minerals are based largely on the prevention of diseases of deficiency such as scurvy in the case of vitamin C. Because diseases of development, degenerative disease and aging itself are partly caused by damage to DNA it seems logical that we should focus better our attention on defining optimal requirements of key minerals and vitamins for preventing damage to both nuclear and mitochondrial DNA.'], ['Mitochondrial OXPHOS defects are responsible for a large group of human diseases and have been associated with degenerative disorders and aging.'], ["Alzheimer's disease (AD) is a neurodegenerative disorder and the most common cause of dementia in the industrialised world."], ['Among cholinergic markers, marked decreases in nicotine binding have been most consistently observed in the telencephalic regions of demented patients and are thought to contribute to the cognitive deficits associated with ageing and age-related neurodegenerative diseases.'], ['This widely expressed enzyme constitutes an important repair mechanism for oxidatively damaged proteins, which accumulate during the manifestation of certain degenerative diseases and aging processes.'], ['AAR has already been discussed as a relevant pathophysiological factor in the pathogenesis of diseases of old age such as atherosclerosis, lung emphysema, presbyopia, cataract, degenerative diseases of cartilage and cerebral age-related dysfunctions.'], ['These data indicate that accumulation of the 4977-bp common deletion in mitochondrial DNA in midbrain occurred primarily in neurons, and by this cytological approach, it was not associated with nigral neurodegeneration in the common movement disorders or aging.'], ['Furthermore, we have shown that the lack of estradiol increases the vulnerability of the brain to injury and neurodegeneration.'], ["Alzheimer's disease (AD) is the most common form of neurodegenerative disease, with dementia, in the elderly."], ["Sporadic IBM has an unknown etiology, although affected muscle fibers are characterized by many of the pathobiochemical alterations traditionally associated with neurodegenerative brain disorders such as Alzheimer's disease."], ['The hippocampal formation (HF) is thought to be critically involved in the encoding and retrieval of such associations, consistent with neuroimaging findings that the HF is damaged in early stages of neurodegenerative disease and in older people with AL impairments.'], ["Alzheimer's Disease (AD) is a progressive neurodegenerative disease that is prevalent among the elderly."], ['Quantitative diffusion tensor analysis correlate with normal aging and may help in assessing normal age-related changes and serve as a standard for comparison with neurodegenerative disorders.'], ['Furthermore, the ability of somatic mtDNA mutations to expand (required for their phenotypic expression), as well as their apparently high incidence, reinforces the possibility that these mutations may be involved actively in various physiological processes such as aging and degenerative disease.'], ['Twenty-four of the included patients had degenerative or vascular lesions, or both.'], ["OBJECTIVE: Over the past two decades, a number of systems have been developed for the classification of cognitive and behavioural abnormalities in older people, in order that individuals at high risk of developing neurodegenerative disease, particularly Alzheimer's disease, may be identified well before the disease manifests clinically."], ['However, the in vitro-findings have rarely been compared with histomorphological changes in aging human tissue or in age-related degenerative diseases.'], ["Idiopathic Parkinson's disease (PD) is an age-related neuro-degenerative disorder characterized by slowness, stiffness, resting tremor, gait impairment, and postural instability."], ['The reported association between vascular dysfunction and neurodegenerative diseases prompted us to investigate the effect of l-deprenyl, a MAO-B inhibitor, on low density lipoprotein (LDL) oxidation.', 'Prophylactic use of low doses of l-deprenyl may accord protection against vascular and neurodegenerative diseases associated with aging.'], ['Responses to oxidative stress and their subsequent interactions in tissues result in the deleterious effect of ROS on the cellular function, which culminate in aging and degenerative diseases.'], ['Based on these findings, it is suggested that the increased level of total NF proteins in CSF could be used as a marker for brain aging and neurodegenerative disorders in general, and the levels of pNF-H/M as a marker to discriminate AD from normal brain aging and as well as neurological conditions including VaD.'], ['Taken together, the data provide strong support for the potential utility of telomerase detection and inhibition for cancer, and telomerase activation for degenerative diseases.', 'Unfortunately, the strong link between telomerase and cancer has led some to confuse telomerase activation with cancer, and others to overstate the cancer risk of telomerase activation therapies for degenerative diseases.', 'This extended view of the telomere hypothesis helps explain how telomerase inhibition can be therapeutic in cancer patients, while controlled telomerase activation for degenerative diseases may actually reduce, rather than increase, the frequency of age-related tumorigenesis.'], ['Increase in oxidative stress has been regarded as an important underlying factor for a number of human health problems including cardiovascular diseases, aging, as well as many age-related neurodegenerative diseases.'], ['CONCLUSIONS: Heat shock protein 27 and HSP72 are thus considered to be useful molecular indicators for degenerative change in intervertebral discs.'], ['Herein, the concept of central nervous system (CNS) degenerative diseases as disorders of specific proteins is introduced.'], ['Patients with neurodegenerative disorders also run a higher risk for being depressed.'], ['Discounting and the use of idealised lifetables as a standard increase the burden of mortality of degenerative disease at the end of life.'], ['Recommendations are made for dietary practices to moderate growth in our youth and to postpone development of chronic or degenerative diseases.'], ["However 'there are no diseases peculiar to old age and very few from which it is exempt' (Alfred Worcester, 1855-1951), and so society will inevitably accumulate a significant share of degenerative diseases within the ranks of its senior citizens."], ['Implication of free radicals in aging and in age-dependent susceptibility to neurodegenerative diseases will be discussed in light of this simplified kinetic model.'], ['Analysts have divided the mortality transition into stages: (1) high, pretransitional mortality, (2) early transitional mortality with the decline explained by the conquest of infectious disease, and (3) late transitional mortality largely attributable to degenerative disease.'], ['Free radicals and oxidative stress have been recognized as important factors in the biology of aging and of many age-associated degenerative diseases.'], ['Increase in 3-NT containing protein (3-NT protein) was reported in brains from patients with some neurodegenerative disorders and aging.'], ['Ageing is characterized by a pro-inflammatory status which could contribute to the onset of major age-related diseases such as cardiovascular diseases, neurodegeneration, osteoarthritis and osteoporosis, and diabetes.'], ['These toxic actions can be expressed either as developmental effects or as an increased risk of neurodegenerative diseases in old age.', 'Metals have also been implicated in neurodegenerative diseases, although it is unlikely that they are the sole cause for any of them.'], ['Currently available clinical data suggest olanzapine is predictably safe in treating adult patients of any age with schizophrenia and acute bipolar mania, as well as in treatment of patients with some types of neurodegenerative disorders.'], ['One problem of current interest is the role of endogenous DNA damage and repair in human pathology, especially neurodegeneration exemplified by many XP patients.', 'Cancer and neurodegeneration may represent converse responses of dividing and nondividing cells to mutagenic and lethal effects of DNA damaging agents.', 'Cell death from endogenous oxidative DNA damage (apoptosis) may be antagonistic to malignant transformation in dividing cells but may cause neurodegeneration in nondividing neural tissue.', 'Small reductions in the efficiency of repair, especially transcription-coupled repair, may overemphasize carcinogenesis in mice, while minimizing neurodegeneration, as compared to human patients.'], ['Ageing is accompanied by a general decline of physiological function, especially at later stages, and significant increases in the incidence of cancer and other degenerative diseases.'], ["Increasing evidence suggests that up-regulation of the cAMP-second messenger system is implicated in Alzheimer's disease neurodegeneration.", 'We suggest that increased vascular cAMP immunostaining is mainly localised in the selectively vulnerable targets of neurodegeneration that characterise AD.'], ["Rett and Angelman's syndromes have emerged slowly from their initial classifications as degenerative disorders and static encephalopathies; the terms development and developmental arrest have been used for 200 years."], ['Mitochondrial DNA mutations play a major role in human aging processes and degenerative diseases.'], ['Eyeblink classical conditioning is a useful paradigm for the study of the neurobiology of learning, memory, and aging, which also has application in the differential diagnosis of neurodegenerative diseases expressed in advancing age.'], ['The cholinergic system has long been implicated in cognition, and there is a plethora of data showing that cholinergic deficits parallel cognitive impairments in animal models and those accompanying neurodegenerative diseases or normal aging in humans.', 'Our understanding of the role of histamine in learning and memory is still at its dawn, but progresses are being made to the point of suggesting potential treatment strategies that may produce beneficial effects on neurodegenerative disorders associated with impaired cholinergic function.'], ['Excessive ROS can induce oxidative damage in cell constituents and promote a number of degenerative diseases and aging.', 'Intake of exogenous antioxidants (vitamins E, C, beta-carotene and others) could protect against cancer and other degenerative diseases in people with innate or acquired high levels of ROS.', 'Screening human populations for ROS levels could help identify groups with a high level of ROS that are at a risk of developing cancer and other degenerative diseases.'], ['The neuronal ceroid lipofuscinoses (NCLs) are a group of enigmatic neurodegenerative disorders of children that have in common the storage of autofluorescent lipofuscin, or aging pigment, in the brain.'], ["Neurodegeneration in Alzheimer's disease is a pathologic condition of cells rather than an accelerated way of aging.", "On the other hand, there is cumulative evidence from studies in cultured brain cells and on brains that oxidative stress constitutes a main factor in the modification of normal signaling pathways in neuronal cells, leading to biochemical and structural abnormalities and neurodegeneration as related to the pathogenesis of Alzheimer's disease.", "This review is focused on the main protein aggregates responsible for neuronal death in both sporadic and familial forms of Alzheimer's disease, as well as on the alterations in the normal signaling pathways of functional neurons directly involved in neurodegeneration."], ['This could explain the age-associated increased prevalence of cancers, certain autoimmune diseases, and neurodegenerative disorders in older people.'], ['The PFC is vulnerable to neurodegeneration with healthy aging and Alzheimer disease (AD).'], ["Alzheimer's disease is the most frequent neurodegenerative disorder in the aged population and is characterized by the deposition of the 40/42-residue amyloid beta protein (A beta), a proteolytic fragment of the beta-amyloid precursor protein (APP)."], ["Furthermore, these memory deficits can be reversed by intracerebral infusions of PREG-S. Neurotransmitter systems modulated by this neurosteroid were unknown until our recent report of an enhancement of acetylcholine (ACh) release in basolateral amygdala, cortex, and hippocampus induced by central administrations of PREG-S. Central ACh neurotransmission is involved in the regulation of memory processes and is affected in normal aging and in human neurodegenerative pathologies like Alzheimer's disease."], ['Current recommended dietary allowances for vitamins and minerals are based largely on the prevention of diseases of deficiency such as scurvy in the case of Vitamin C. Because diseases of development, degenerative disease and ageing itself are partly caused by damage to DNA, it seems logical that we should focus better our attention on defining optimal requirements of key minerals and vitamins for preventing damage to both nuclear and mitochondrial DNA.'], ['We have therefore examined the choroid plexus of a case with multiple mitochondrial DNA deletions for evidence of accelerated ageing and compared it with two cases with point mutation mitochondrial DNA disorders and several age-matched and elderly controls with and without clinical and neuropathological evidence of neurodegenerative disease.'], ['Several mechanisms of action are useful in explaining how EGb 761 benefits patients with AD and other age-related, neurodegenerative disorders.'], ['Because brain asymmetry develops prenatally, the recognition of asymmetry in neurodegeneration implies a possible relationship between the development of cerebral laterality and regional vulnerability in neurodegenerative diseases.'], ['Whilst techniques are available to study mtDNA rearrangements at the level of the single cell, recent interest has focused on the possible role of somatic mtDNA point mutations in ageing, neurodegenerative disease and cancer.'], ["The non-beta-amyloid (Abeta) component of Alzheimer's disease amyloid (NAC) and its precursor alpha-synuclein have been linked to amyloidogenesis in several neurodegenerative diseases."], ['In addition, recent experimental observations suggest that neurodegenerative disease pathology may involve alterations in a range of progressive neural inductive and neurodevelopmental events through novel biological mechanisms that result in sublethal impairments in cellular homeostasis within evolving regional neuronal precursor populations containing the mutant proteins, culminating in increased vulnerability of their differentiated neuronal progeny to late-onset apoptosis.', 'Evolving regenerative strategies for both neurodevelopmental and neurodegenerative diseases will likely involve the targeting of vulnerable regional neural precursor populations during "presymptomatic" clinicopathological stages prior to the occurrence of irrevocable neural cell injury and cell death.'], ['It is a relentless, degenerative brain disease, characterized by progressive cognitive impairment.'], ["Alzheimer's disease (AD) is a neurodegenerative disorder of the elderly with a complex etiology due to the interaction between genetic and environmental factors."], ['A significant increase in the number of old people in the populations of developed countries was followed by an increase in morbidity and mortality resulting from main age-related diseases -- cardiovascular, cancer, neurodegenerative, diabetes mellitus, decrease in resistance to infections.'], ['We found that the 5A5A and 5A6A genotype in the elderly was associated with a significantly larger number of degenerative IVDs than the 6A6A (p < 0.05), but there was no significant difference in the young.'], ["Mitochondrial dysfunction is a cause, or major contributing factor in the development, of degenerative diseases, aging, cancer, many cases of Alzheimer's and Parkinson's disease and Type II diabetes (D. C. Wallace, Science 283, 1482-1488, 1999)."], ["INTRODUCTION: Parkinson's disease is one of the commonest neurodegenerative diseases of the elderly."], ['The major role of G6PD is to generate NADPH to protect cells from oxidative damage, which is a major contributing factor to certain degenerative diseases, such as aging and cancer.'], ['In general terms, cancer can be regarded as a degenerative disease of ageing.'], ['The reactive cellular products generated during the peroxidation of membrane lipids have been implicated as causative agents in a variety of degenerative diseases and aging.', 'Targeting of hGSTA4-4 to the mitochondrion holds implications for degenerative diseases associated with oxidative stress that arise from aerobic respiration.'], ['Substantial evidence indicates that bioenergetic dysfunction plays either a primary or secondary role in the pathophysiology of cell death in neurodegenerative and neuromuscular disorders, and even in normal aging.'], ['Therefore, acquired mtDNA mutations might preferentially accumulate in the brain and could play a role in aging and neurodegenerative disorders.'], ["We also consider the possible basis for decreased DeltaPsi(M) in fibroblasts from patients with Parkinson's disease, an age-related neurodegenerative disease."], ['In addition, recent findings have linked alterations in SM metabolism to the pathogenesis of several age-related diseases including cancers and neurodegenerative disorders.'], ['Analysis of the spin mutant will give us new insights into neurodegenerative diseases and aging.'], ['Increasing lines of evidence suggest a key role for mitochondrial damage in neurodegenerative diseases.', 'This paper reviews the mechanisms of N-acetylcysteine action at the cellular level, and the possible usefulness of this antioxidant for the treatment of age-associated neurodegenerative diseases.', 'In view of the above, and because of the ease of its administration and lack of toxicity in humans, the potential usefulness of N-acetylcysteine in the treatment of age-associated mitochondrial neurodegenerative diseases deserves investigation.'], ['Our results demonstrate that the aged brain is capable of providing the necessary environment for HNSCs to retain their pluripotent status and suggest the potential for neuroreplacement therapies in age-associated neurodegenerative disease.'], ["Increasingly, these 'atypical' drugs are being used in the treatment of psychotic or related behavioural disturbances in patients with neurodegenerative disease.", 'The relationship between drug pharmacology and neurotransmitter pathology is essential to understanding the relative efficacy of individual antipsychotic drugs in treating the psychotic and behavioural disturbances of neurodegenerative disorders.'], ['Taken together these data indicate that the immunoneuroendocrine balance is maintained in physiological aging, whereas NK immune dysregulation in DAT could contribute to altering the neuroendocrine functions and to extend the progression of neurodegeneration and dementia.'], ['Respiratory chain deficiency and cell loss and/or apoptosis have been associated with neurodegeneration, heart failure, diabetes mellitus, and aging.'], ["BACKGROUND: Abnormalities at several levels of the hypothalamic-pituitary-adrenal axis, which may promote glucocorticoid dependent neurodegeneration, have been reported in patients with Alzheimer's disease."], ['Mitochondrial DNA (mtDNA) mutations have been proposed as a genomic biomarker in the process of human ageing, degenerative diseases and carcinogenesis.'], ['GBLE inhibited the increase in the products of the oxidative decomposition low-density lipoprotein (LDL), reduced the cell death in various types of neuropathy, and prevented the oxidative damage to mitochondria, suggesting that GBLE exhibits beneficial effects on neuron degenerative diseases by preventing chronic oxidative damage.'], ['For this gene-preserving reason, degenerative spinal disorders will likely be a part of modern societies for the foreseeable eternity of the race.', 'The detailed alterations accruing from the interrelated consequences of and phenomena contributing to acquired degenerative changes of the lumbosacral intervertebral segments as detailed in this discussion highlight the extraordinary problems that are associated with degenerative disease in this region of the spine.'], ['Ordinary degenerative disorders affect MM patients earlier in life than normals.'], ['In ageing and age-related neurodegenerative disorders nAChR deficits are predominantly associated with alpha4-containing receptors, although some studies also indicate the involvement of alpha3 and alpha7 subunits.'], ["Parkinson's disease (PD) is a neurodegenerative disorder of the aging population with unknown etiopathogenesis."], ["INTRODUCTION: Population aging in Brazil has increased the prevalence of neurodegenerative diseases (Parkinson's and Alzheimer's disease) and affective disorders (anxiety, depression), all common in old age."], ['Mice transgenic for lacI (Big Blue) and human mutant (1Gurd(1), Mut hSOD1) or wild type (2Gur, Wt hSOD1) SOD1 genes were used to examine spontaneous mutation, oxidative DNA damage, and neurodegeneration in vivo.', 'This first report of an endogenous factor that can reduce in vivo, the frequency of spontaneous mutation suggests potential strategies for lowering mutagenesis related to aging, neurodegeneration, and carcinogenesis.'], ["Elderly humans have altered cellular redox levels and dysregulated immune responses, both of which are key events underlying the progression of chronic degenerative diseases of ageing, such as atherosclerosis and Alzeimer's disease."], ["This has provided direct evidence for the hypothesis that aberrant, filamentous assembly of tau, a frequent hallmark of a series of human cognitive diseases, including Alzheimer's disease, can directly provoke neurodegeneration."], ["Alzheimer's disease is a degenerative disorder characterised by cerebral atrophy with cortical and subcortical changes."], ["Estrogen replacement therapy in postmenopausal women ameliorates cognitive dysfunction and decreases the risk and/or severity of neurodegenerative conditions such as Alzheimer's disease and stroke.", 'However, neurodegenerative events occur more frequently in elderly women who are chronically hypoestrogenic.'], ['We found no evidence that these somatic mtDNA point mutations accumulate either in the brains of normal elderly individuals or in the brains of individuals with neurodegenerative disease.'], ['The accuracy of DXA, particularly at the lumbar spine, can be affected by several factors such as degenerative diseases.'], ['A better understanding of the molecular signaling mechanisms that permit such cell survival and synaptic plasticity may therefore lead to the development of new preventative and therapeutic strategies for age-related neurodegenerative disorders.', 'Collectively, the available data suggest the that dietary restriction, and physical and mental activity, may reduce both the incidence and severity of neurodegenerative disorders in humans.'], ['Neurodegenerative diseases cost the economies of the developed world billions of dollars per annum.'], ['Ischaemic and degenerative brain diseases are a major health problem leading to a devastating loss of autonomy.'], ["Future studies will be required to address the potential for creatine monohydrate supplementation to attenuate age-related muscle atrophy and strength loss, as well as to protect against age-dependent neurodegenerative disorders such as Parkinson's disease and Alzheimer's disease."], ["Alzheimer's disease is a progressive neurodegenerative disorder with characteristic clinical and neuropathological features."], ['Collectively, our findings suggest that HO-1 over-expression contributes to the pathological iron deposition and mitochondrial damage documented in these aging-related neurodegenerative disorders.'], ['Premature death in transgenic mice that overexpress mutant Amyloid precursor protein is preceded by severe neurodegeneration and apoptosis.'], ["By the anti-apoptotic function, rasagiline may rescue or protect declining neurons in aging and neurodegenerative disorders, such as Parkinson's disease."], ['Although conclusions from early studies remain somewhat preliminary, it is likely that the IGF regulatory system will be a prime target for future studies into the pathogenesis of several age and sex hormone related degenerative disorders.'], ['DR increases resistance of neurons to dysfunction and degeneration, and improves behavioral outcome, in experimental models of AD and other age-related neurodegenerative disorders by a mechanism involving a mild stress response.', 'TERT exhibits neuroprotective properties in experimental models of neurodegenerative disorders suggesting that manipulations that induce telomerase in neurons may protect against age-related neurodegeneration.'], ['Knowledge of the properties of peripheral (tibial) trabecular bone is of major importance for the understanding of degenerative diseases such as osteoarthrosis and osteoporosis, and for the design, fixation and durability of total joint prosthesis.'], ['Activation of this HO-1-MnSOD axis may play an important role in the pathogenesis of Alzheimer disease, Parkinson disease and other free radical-related neurodegenerative disorders.'], ['We examined the presence of ubiquitin-immunoreactive skein-like inclusions (SLI) in the neostriatum and spinal cord in normal individuals and patients with different neurodegenerative diseases.', 'Ubiquitin-immunoreactive SLI in the neostriatum were observed both in the normal individuals and in the patients with a variety of neurodegenerative diseases.', 'In particular, SLI were frequently seen in normal aged subjects and certain neurodegenerative diseases, such as progressive supranuclear palsy and myotonic dystrophy.', 'On the other hand, SLI in the spinal anterior horn were detected in cases of amyotrophic lateral sclerosis, but not in any cases with other neurodegenerative diseases.', 'Our findings indicate that SLI in the neostriatum are ubiquitin-related structures whose occurrence increases by aging, and less frequently accompany several neurodegenerative diseases, and are identical to at least some RLI.'], ['BACKGROUND: Kraepelin originally conceptualized schizophrenia as a degenerative brain disorder.'], ['The expression of the 5-LOX gene is upregulated during neurodegeneration and with aging.', 'We propose that the 5-LOX inflammatory cascade may take part in the process of aging-associated neurodegenerative diseases, and we point to the role of 5-LOX in neurodegeneration and discuss its relevance for anti-inflammatory therapy of AD.'], ['Additionally, aging animals that are kept for prolonged periods of time after chronic brain hypoperfusion, also develop brain capillary degeneration in CA1 hippocampus and neuronal damage extending from the hippocampal region to the temporo-parietal cortex where neurodegenerative tissue atrophy eventually forms.'], ['BACKGROUND: Although oxidative stress has been implicated in the pathogenesis of neurodegenerative diseases, data found in the literature are still a matter of controversy.'], ['We hypothesize that overexpression of TIMP-3 may prove to be a critical step in the progression of a variety of degenerative retinopathies.'], ['In recent years, there has been increased concern that the etiology of some neurodegenerative diseases may be associated with exposure to neurotoxic agents and that subpopulations of humans such as children and the elderly may be differentially sensitive to neurotoxic exposure.'], ['These events contribute to the progressive cognitive decline characteristic of patients with AD, as well as regional anatomic pathology, consisting of synaptic loss, senile plaques, neurofibrillary tangles, tissue atrophy, and neurodegeneration.'], ['increase in number in patients suffering from neurodegenerative diseases.'], ['We propose that two factors converge to initiate cognitive dysfunction and neurodegeneration as expressed in AD brain: (1) advanced aging, and (2) the presence of a condition that lowers cerebral perfusion.'], ['Both aging and age-associated neurodegenerative diseases are associated with various degrees of behavioral impairments, and among the prime candidates responsible for producing the neuronal changes mediating these behavioral deficits appear to be free radicals and the oxidative stress they generate.'], ['Aluminum is a neurotoxic agent for animals and humans that has been implicated as an etiological factor in several neurodegenerative diseases and as a destabilizer of cell membranes.'], ["Recently, inflammatory pathways have been recognized as possible pathophysiological mechanisms of aging-associated neurodegenerations, and slowing of the progression of Alzheimer's disease can be achieved with anti-inflammatory drugs."], ['UNLABELLED: Osteoarthritis (OA) has been characterized as a slowly evolving degenerative disease affecting cartilage and bone, with a multifactorial etiology that may differ depending on the joint site.'], ['These results suggest that overproduction of apoE protein may be a consequence of astroglial response to neurodegeneration in AD and that the determination of CSF apoliprotein levels serves as a clinical marker for monitoring the progression of AD.'], ["Chronic neurodegeneration in the brains of Alzheimer's disease (AD) patients may be mediated, at least in part, by the ability of amyloid beta (Abeta) to exacerbate inflammatory pathways in a conformation-dependent manner."], ['This unpredictability is particularly evident among the frail elderly, who are at the upper extreme of the life cycle and often suffer from central neurodegenerative disorders and/or a significant burden of comorbid medical problems.'], ['It has been hypothesized that striatal neurodegeneration caused by excitotoxic mechanisms and oxidative stress may play an important role in the development of the disorder, and the scope of the present work is to review the evidence supporting this hypothesis.'], ['MtDNA defects and the resulting mitochondrial dysfunction is an important contributor to human degenerative diseases, ageing and cancer; (ii) mtDNA is a significant target of ultraviolet radiation and current work shows that it may be useful as a candidate biomarker of cumulative exposure in skin; and (iii) there is a broad spectrum of skin manifestations that are signs of mitochondrial disorders; in addition, the frequency of skin findings in these syndromes is probably under-reported.'], ['Thus, the relationship between APP and Abeta deposition during brain aging could shed light on the processing of APP into Abeta, neurodegeneration, and possible protection of neurons that are functioning in spawning but senescent salmon.'], ['Additional latency delays are observed in neurodegenerative disorders.'], ['The role of HRT and/or oestrogens in the aetiology, progression and prevention of neurodegenerative disorders is unclear.'], ['Neurodegenerative disorders are among the most challenging and devastating illnesses in medicine.', 'While treatment of patients with progressive neurodegeneration remains daunting, increased knowledge of the aetiology and pathogenesis of these diseases has provided new opportunities and a new understanding of their treatment needs.', "In this article, we briefly describe the effects of ageing on the brain, and introduce two of the major neurodegenerative disorders, Alzheimer's and Parkinson's diseases.", 'Where possible, individuals with neurodegenerative disorders should always be treated by the same dentist.'], ['This has led to an increasing interest in the association between postmenopausal estrogen deficiency and degenerative diseases associated with aging such as cardiovascular disease, osteoporosis and dementia.'], ["Many hypotheses have been developed to explain aging and age-related neurodegenerative disorders; one of the most compelling is the role of oxidative stress to induce changes in protease activity in brains of patients of Alzheimer's disease and prion disease.", 'In this article we would like to point out the importance of a copper(II)-peroxide adduct to promote neurodegenerative diseases such as prion disease and amyotrophic lateral sclerosis through its oxidative protease function.'], ['The profiles of the colored and black groups reflect that of disadvantaged population groups (a high prevalence of infectious disease; relatively young populations), whereas the white donor profile is that of a privileged population group (a high prevalence of degenerative disease; aging population).'], ["Apoptosis is essential for normal human neurodevelopment and is increasingly recognized for its role in various neurodegenerative diseases such as Alzheimer's and Parkinson's diseases.", 'Interestingly, Bcl-2 protein levels are altered in certain neurodegenerative disorders that reveal increased apoptosis.'], ["Synaptic degeneration and death of nerve cells are defining features of Alzheimer's disease (AD) and Parkinson's disease (PD), the two most prevalent age-related neurodegenerative disorders."], ["Citicoline has been extensively used for the treatment of neurodegenerative disorders associated with head trauma, stroke, brain aging, cerebrovascular pathology and Alzheimer's disease."], ['Increased expression of alphaB-crystallin is seen in a number of age-related degenerative diseases.'], ['However, pharmacological approaches which break the vicious cycles of oxidative stress and neurodegeneration offer new opportunities for the treatment of AD.'], ["In order to reveal a possible common process during ageing and Parkinson's disease neurodegeneration, catecholaminergic neurons of five anatomical regions of the brainstem (substantia nigra, central grey substance, ventral tegmental area, peri- and retrorubral area, and locus coeruleus) have been quantified using immunohistochemical staining for tyrosine hydroxylase (TH) on regularly spaced sections, between the rostral and caudal poles of the mesencephalon and in the rostral pole of the pons, in post-mortem samples of 21 control subjects who died at ages 44-110 years."], ['Funding levels at the National Institutes of Health will likely increase in order to expand these emerging fields as well as provide avenues for translating fundamental knowledge into solving the complexities of a number of degenerative diseases influenced heavily by activity/inactivity factors such as cardiopulmonary disease, diabetes, obesity, and the debilitating disorders associated with aging.'], ['The delay of independence and the increasing length of maturation required that the schedule of AD-like neurodegeneration be slowed, otherwise parental caregivers would already have become impaired.'], ['Hence, dysregulation of apoptosis has been implicated in autoimmune disease, acquired immune deficiency syndrome, and other viral (and bacterial) infections, as well as in neurodegenerative disorders and cancer.'], ['Generalised-onset seizures also occur, perhaps as a result of diffuse changes with aging or degenerative disease or to a combination of genetic and environmental factors.'], ['The aging of the population in developed countries has been associated with a growing burden of degenerative joint disease and hip fracture, and this has contributed to a progressive increase in the utilisation of major hip and knee arthroplasty.'], ['APP23 mice on an App-null background developed a similar degree of both plaques and CAA, providing further evidence that a neuronal source of APP/Abeta is sufficient to induce cerebrovascular amyloid and associated neurodegeneration.'], ['Degenerative joint disease, although effecting most persons as they age, is not a certain result of aging and disability as the condition is reduced in the active person.'], ['Mania in old age represents a syndrome involving affective vulnerability in association with neurologic lesions that affect specific areas of the brain.'], ['Oxidative damage to DNA may play a role in both normal aging and in neurodegenerative diseases.'], ['Alpha synuclein has been specifically implicated in neurodegenerative disease.', 'Such a process may be important for lifelong learning and memory functions and may be especially vulnerable to disruption in aging-associated neurodegenerative diseases.'], ['OBJECTIVE: To advance our understanding of the natural history of Abeta in neurodegenerative diseases.'], ['Mitochondrial oxidative damage contributes significantly to a range of human disorders, including neurodegenerative diseases, ischaemia-reperfusion injury and ageing-associated dysfunction.'], ["Moreover we investigated this marker of oxidative stress in patients with Alzheimer's disease (AD), an age-related neurodegenerative disorder in the development of which free radicals have been involved."], ["Huntington's disease (HD) is an autosomal dominant degenerative disease of the central nervous system manifested by involuntary movements (chorea), psychiatric manifestations, and cognitive impairment with a variable age at onset."], ['We propose that two factors need to be present before cognitive dysfunction and neurodegeneration is expressed in AD brain: advanced aging, and the presence of a condition that lowers cerebral perfusion.'], ["Alzheimer's disease (AD) is a chronic neurodegenerative disorder with an impact on public health which continues to increase with the increasing longevity of the population.", 'New strategies will be required to slow, stop or reverse the effects of neurodegeneration in AD.'], ['It is now medically recognized that sagging skin and other signs of degenerative skin conditions, such as wrinkles and age spots, are caused primarily by oxy-radical damage.'], ['The identification of further genes responsible for PD will subsequently lead to first insights into the pathogenesis of one of the most common neurodegenerative disorders in humans.'], ['In summary, research on genetic polymorphisms related to AD and involved in receptors, transporter proteins and the enzymatic machinery of serotonin might enhance our understanding of this devastating neurodegenerative disorder.'], ['Indeed, it might be essential to have an adequate intake of antioxidant nutrients from an early age in order to help prevent the development of, or at least delay the onset of, several degenerative disorders.'], ['Furthermore, LB are occasionally observed in some other neurodegenerative diseases and in normal aging.', 'The absence of alpha-synuclein reactivity in the LB in this symptomless patient corroborates the hypothesis that alpha-synuclein accumulation in LB is an important step in neurodegeneration in PD and DLB, but tones down the role of alpha-synuclein in LB formation in general.'], ['The dog could be used as a natural animal model for the study of normal aging and human neurodegenerative diseases.'], ['The oxidation of lipids and cell membranes generates cytotoxic compounds implicated in the etiology of aging, cancer, atherosclerosis, neurodegenerative diseases, and other illnesses.'], ['METHODS: We used the medical records linkage-system of the Rochester Epidemiology Project to identify all individuals whose records contained documentation of any form of parkinsonism, related neurodegenerative diseases, or tremor of any type.'], ['Individuals in the same age group had a similar range of amounts of both TTAGGG and CCCTAA in the same organ of the same individual, (except for those with unusually low telomeres often had chronic degenerative diseases, and those who had exceptionally high telomere levels often had excellent physical conditions or mental acumen).'], ['An increased [Ca2+]i in AD is consistent with processes leading to neurodegeneration in AD.'], ["Parkinson's disease (PD) is a neurodegenerative disease caused by a multitude of environmental, neurochemical, and genetic factors."], ["Mitochondrial DNA mutations also may play an important role in aging, as well as in common age-related neurodegenerative disorders such as Parkinson's disease."], ['Over the past 10 years, mitochondrial defects have been implicated in a wide variety of degenerative diseases, aging, and cancer.'], ['These observations warrant the reassessment of the conventional concept that the accumulation of pathogenic mutations in mtDNA throughout the aging process is responsible for the decrease of mitochondrial respiration capacity with age and with the development of age-associated neurodegenerative diseases.'], ['A gradual loss of olfactory capability with age and in a number of neurodegenerative diseases is common, and mechanisms underlying these losses are not understood.'], ['This concept envisages that a tissue-bioenergetic decline will be intrinsic to various diseases of the aged and thereby contribute to their pathology, in particular, heart failure, degenerative brain disease, muscle and vascular diseases, as well as other syndromes.'], ['This may also play some role in the pathogenesis of degenerative diseases and the age-dependent progression of the clinical course of mitochondrial diseases.'], ['Apopotic cell death is reported to be prominent in the stable tissues of the failing heart, in cardiomyopathies (CM), in the sinus node of complete heart block, in B cells of diabetes mellitus, and in neurodegenerative diseases.'], ['Details of such an experimental aluminum encephalopathy produced in the rabbit are discussed, along with other aspects of aluminum-induced neurodegeneration.'], ['This and its expression profile raise the possibility that it may be involved in neurodegenerative disease.'], ['A survey of 200 surgically excised valves in 1996, from a single academic center, revealed that degenerative disease is by far the most common type of underlying pathology, both for the mitral valve and the aortic valve.'], ['A number of age-related neuromuscular degenerative diseases also have been associated with mutations in mitochondrial DNA (mtDNA), and progressive accumulation of oxidative damage in mtDNA from neuronal tissues over time has been shown.'], ["Changes in the number of high-affinity nicotine binding sites have been widely reported in specific regions of the human brain during aging and in degenerative neurological diseases associated with aging, such as Alzheimer's disease."], ['In addition, there is an age-associated increase in the metabolic turnover of cellular proteins, such as glial fibrillary acidic protein, in human brain tissue, even without detectable signs of neurodegeneration.', 'Understanding the role of glia in age-associated neurodegenerative disorders may provide new insights into the neurobiology of glia-neuronal interaction and may allow the development of strategies to alter the disease process.'], ["The potential clinical benefit of melatonin as an antioxidant is remarkable, suggesting that it may be of use in the treatment of many pathophysiological disease states including various cancers, hypertension, pulmonary diseases, and a variety of neurodegenerative diseases such as Alzheimer's disease."], ['However, biochemical changes in the aging brain and changes in neurodegenerative disorders are of importance.'], ['The oxidative damage that occurs to DNA may play a role in both normal aging and neurodegenerative diseases, including AD.'], ['Extreme variations in the sulcal patterns of the human cortex have made it difficult to identify diffuse and focal variations in cortical structure in neurodegenerative disease.'], ['Moreover, age-related neurodegenerative diseases may evolve from the interaction between defects in specific neurochemical mechanisms and as-yet undefined pathophysiologic processes.'], ['Our data suggest that environmental neurotoxins metabolized by PON1 might be responsible for neurodegeneration with aging and that the B (Arg) allele form might have genetic susceptibility to PD.'], ['These data suggest that basic gene induction mechanisms, which have been conserved over long periods of evolution, that increase NF-kappaB-DNA binds ing may be fundamental in driving transcription from inflammation-related genes, such as COX-2, that operate in stressed tissues, in normally aging cell lines, and in neurodegenerative disorders that include AD brain.'], ['The search for the causes of neurodegenerative disorders is a major theme in brain research.'], ['RESULTS: Occurrence of clonal expansions of T cells was strikingly high in patients with idiopathic sensory neuropathies (16/20, 80%), with a similar proportion in CIAP (12/15, 80%) and CIAN (4/5, 80%), as compared with elderly normal controls (2/10, 20%), elderly controls with degenerative neurologic diseases (2/10, 20%), and elderly patients with idiopathic chronic inflammatory demyelinating polyneuropathy (2/10, 20%) (all p < 0.005).'], ['As with other synucleins, persyn is believed to be involved in the pathogenesis of human neurodegenerative diseases.', 'Detailed characterization of the human persyn locus is important for further studies of the involvement of persyn in neurodegeneration and malignancy.'], ['Progress in 5-HTT gene inactivation studies are also changing views of the relevance of adaptive 5-HT uptake function in brain development and plasticity as well as processes underlying drug dependence and neurodegeneration.'], ["Alzheimer's disease (AD) and other dementias are common degenerative disorders in the elderly."], ['Diagnosis is sometimes delayed as patients or family members often misattribute obvious manifestations of cognitive decline to normal aging rather than to the onset of a degenerative disease.'], ['Oxidative damage to mitochondrial DNA has been implicated in human degenerative diseases and aging.'], ['BACKGROUND: It has been suggested that the accumulation of damage to mitochondrial DNA is a major cause of age related, degenerative disease.'], ['All of the patients with signs of CVD at autopsy were also found to have some concomitant neurodegenerative disease.'], ['The follow-up progress of the atrophic-degenerative illness leads to overlapping of the specific neuropsychological syndrome by global cognitive impairment.'], ['This study documents the validity and usefulness of our approach in unravelling the neural substrates of cognitive impairment in brain pathology without focal tissue loss such as that seen in neurodegenerative diseases.'], ['However, high-impact and torsional loads may increase the risk of degeneration of normal joints, and individuals who have an abnormal joint anatomy, joint instability, disturbances of joint or muscle innervation, or inadequate muscle strength or endurance probably have a greater risk of degenerative joint disease.'], ['This development together with the as yet unknown etiology of many neurodegenerative disorders has caused an increased interest in the biology and pathophysiology of mitochondria.', 'Dysfunction of mitochondria has been linked to both normal aging and neurodegenerative disorders, with the latter occurring much more frequently at higher age.', 'There is evidence, however, that mutations of the mitochondrial genome may increase the susceptibility to neurodegeneration.'], ['It has been observed that susceptibility to many degenerative diseases increases concurrently with industrialization and rising living standards.'], ['Age-related human neurodegenerative diseases are a major social and medical problem.', 'It is therefore logical to take into consideration every theory with an overall approach to neurodegenerative diseases.', "This environmental proposal relies mainly on data concerning the Western Pacific amyotrophic lateral sclerosis-Parkinsonism-dementia complex (WP ALS-PD) considered as 'a prototypal human neurodegenerative disease' and on extrapolation from it to the bulk of neurodegenerative diseases (NDD).", 'NDD would be due to an accelerated ageing process in certain populations of neurons due to the noxious synergy of (1) increased environmental slow deleterious factors (such as slow toxins) and of (2) decreased environmental protective factors (Mg deficient intake particularly).', 'The post-Second World War decline of the occurrence of WP ALS-PD in all three high incidence disease foci coupled with the absence of demonstrable heritable or transmissible factors had led to focus the search for the cause of this degenerative disease on nontransmissible environmental factors that are disappearing as the susceptible population groups acculturate to modern way.', 'Combined Al intoxication with Ca-Mg deficiencies is a reasonable model to investigate the pathogenesis of neurodegenerative diseases and eventually to screen their treatments.', 'Magnesium deficiency cannot result in neurodegenerative disease.'], ['There is considerable support for the concept that oxygen free radicals and related lipid peroxides play a key role in the pathogenesis of normal senescence and of age-related chronic degenerative diseases, including atherosclerosis.'], ['All subjects underwent a neuropsychological test battery that included tasks found to be sensitive to dopamine alterations in patients with neurodegenerative disease and control tasks.'], ['Neurodegeneration and deposition of fluorescent lipid bodies are the neuropathological hallmarks of this disease.'], ['With the exception of cases in which a neurologic lesion can be demonstrated, the etiology of UUI remains elusive.'], ['He had concomitant decreased functional mobility from degenerative joint disease of both knees, which limited his ambulation capability.'], ["Alzheimer's disease (AD) is a neurodegenerative disorder of the brain characterized by the presence of neuritic amyloid plaques and neurofibrillary tangles."], ['In this work, the tertiary butylhydroperoxide- (t-BuOOH) treated mouse was used as a model to study the oxidative stress that is associated with various neurodegenerative diseases.', 'These results directly implicate DNA damage in neurodegeneration.'], ["The integration of results from this study, and from studies on normal aging and Alzheimer's disease, supports a model suggesting that hippocampal size may be an indicator of long-term memory ability, but only when hippocampal measures reflect aging and degenerative hippocampal atrophy."], ["The present paper addresses some basic problems and their solutions in the actigraphic assessment of movement, motor symptoms, circadian rest-activity rhythms, and nocturnal agitation in healthy elderly and elderly suffering from a neurodegenerative disease (i.e., Parkinson's disease or Alzheimer's disease) and summarizes the results of previous and ongoing research."], ['The central role that alterations of the mitochondria and mtDNA may play in aging and age-related degenerative diseases is discussed in relation to the "Mitochondrial theory of aging."'], ['Oxidative DNA damage is important in aging and the degenerative diseases of aging such as cancer.'], ["Alzheimer's disease (AD) is a common neurodegenerative disorder and a leading cause of death among the elderly."], ['Various neuronal degenerative diseases are characterized by late onset, relentless progression, and finally death.', 'The study of human neurodegenerative diseases is complicated by the difficulty of obtaining tissue samples at various stages of progression, especially early in the course of the disease.', 'Since neurodegeneration occurs in many organisms [3-5], model organisms amenable to genetic and molecular techniques, such as the mouse, offer important advantages.'], ['Accumulation of somatic mutations in the mitochondrial DNA (mtDNA) is a major contributor to human aging and degenerative diseases.'], ['We have examined this question by comparing frontal lobe sections in seven groups of patients: Multi-infarct dementia (n = 6), AD with (n = 10) and without (n = 10) infarcts, age-matched controls with (n = 10) and without (n = 10) infarcts, controls with neurodegenerative diseases other than AD, and young controls (n = 10).'], ['Each of these hormones influences the age-related processes of energy metabolism, fat depot distribution, immune function and neurodegeneration.'], ['One of the most devastating age-associated neurodegenerative disorders, Alzheimer disease, is characterized by neuronal loss and the extracellular deposition in the brain of beta-amyloid peptide, which is presumed to be causally related.'], ['Considering the reasonably high prevalence in the general population of a genetic predisposition to a thermolabile form of the enzyme 5,10-methylenetetrahydrofolate reductase (MTHFR), hyperhomocysteinemia can be seen as the result of multiple genetic and environmental factors leading to vascular and/or neurodegenerative disorders where age-related involutive phenomena represent a common pathogenetic ground.'], ['I have worked as a neurologist in old age homes and chronic hospitals for 30 years, and over this period I have seen thousands of older patients with dementias and other degenerative neurological syndromes.'], ['In adults and older athletes, a further spectrum of injury exists, along with the effects of aging tissues and the concerns of degenerative joint disease.'], ['In a clinically demented patient without vascular or other neurodegenerative lesions, a clinico-pathologic diagnosis of AD (a clinico-pathologic entity) can be made with a high level of confidence by demonstrating, and without counting, plaques and tangles.'], ["West and colleagues optical disector approach likewise shows that neurodegeneration associated within aging individuals' hippocampi is quantitatively and qualitatively distinct from the neuronal loss in AD."], ['At the present time, it is not known whether changes in the BBB contribute to the age-related neurodegenerative diseases or are merely epiphenomena of aging.'], ['Mitochondrial dysfunction is a major contributor to aging and neurodegeneration.'], ["Missense mutations in the beta-amyloid precursor protein gene (APP) co-segregate with a small subset of autosomal dominant familial Alzheimer's disease (FAD) cases wherein deposition of the 39-43 amino acid beta-amyloid (A beta) peptide and neurodegeneration are principal neuropathological hallmarks."], ['Loss of the calcium buffering capacity conferred by CalBP may leave the BFCN vulnerable to damage in neurodegenerative disorders.'], ["Oxidative stress has been implicated in the mechanism of aging and neurodegenerative disorders such as Alzheimer's disease (AD)."], ['Particular emphasis is placed on the chronic degenerative diseases, activities of daily living, and longitudinal patterns of individual change.'], ['METHODS: A 74-year-old patient with history of an epidural abscess underwent elective bilateral total knee arthroplasty for degenerative joint disease.'], ['The progressive aging of the population as a whole, the frequent appearance of degenerative diseases, and the greater frequency of suicide among persons older than 65 years than in younger age groups, are worrisome issues that deserve investigation.'], ['While the onset of neurodegeneration may be tightly programmed, i.e., in a species-specific manner, our data support the idea that the incidence of NPs and NFTs and the progression from NPs to NFTs may vary remarkably, depending on neuronal size.'], ['The diagnosis of degenerative diseases or syndromes in the nervous system in based on their morphological picture.', 'Degenerative syndromes may be classified according to the topography of changes.', 'The cases with two syndromes representative for small infants: progressive poliodystrophy of Alpers type and a degenerative syndrome with cerebral calcifications and disseminated demyelination were examined from this point of view.'], ['Risk factors in this population include genetic vulnerability, psychosocial losses, medical comorbidity, cerebrovascular disease, and neurodegenerative disorders.'], ['Oxidative damage on biological molecules has been proposed as a major cause of alterations observed in aging brain as well as in neurodegenerative diseases.'], ["Parkinson's disease is the one neurodegenerative disorder in which drugs have been demonstrated to be of value."], ['Citicoline is a choline donor involved in the biosynthesis of brain phospholipids and acetylcholine extensively used in the treatment of neurodegenerative diseases.'], ['Hence, these polymorphisms may influence the risk of suffering some types of cancer and other degenerative diseases that are incompatible with extreme longevity.', 'PATIENTS: the three genotypes were determined in 41 nonagenarians (10 males, mean age 92.2 years, range 90-98) free of known malignancies or neurodegenerative diseases.'], ['Chronic deficiency of various vitamins can influence the occurrence of some chronic degenerative diseases such as cancer, cardiovascular pathology, cataract, arthritis, disorders of the nervous system and photosensitivity.'], ['Seizures were attributed to acute stroke (26.1%), trauma (8.7%), subdural haematoma, degenerative diseases of the brain, cerebral metastasis, or central nervous system infections.'], ["Alzheimer's disease is a progressive neurodegenerative disorder that results in tremendous economic and quality-of-life burdens."], ["Parkinson's disease (PD) is a progressive neurological condition that causes considerable disability in the elderly."], ['Such accumulations of activated microglia may contribute towards neurodegeneration via production of cytokines and free radicals.'], ['Major known causes include cerebrovascular disease, brain tumor, degenerative disorders such as Alzheimer disease and cerebral amyloid angiopathy, and toxic-metabolic syndromes such as nonketotic hyperglycemia, postcardiac arrest, and drug-induced seizures.'], ['Oxygen radicals damage biomolecules and may contribute to cellular aging and degenerative disease.'], ['Age-related maculopathy (ARM) is a degenerative disorder of the central part of the retina with a rising prevalence in patients 50 years of age and older, and comprises different histopathological changes.'], ['Investigations of patients with lesions or neurodegenerative disease not involving the cerebellum demonstrate that acquisition of CRs is possible, although prolonged in the case of hippocampal cholinergic disruption.'], ["Accumulation of oxidative DNA damage has been proposed to underlie aging and neurodegenerative diseases such as Alzheimer's Disease (AD)."], ['With advancing age, musculoskeletal soft tissue function declines, susceptibility to degenerative diseases and injuries increases, and the ability to recover from disease or injury declines; these changes increase the probability of impairment (Fig.', 'Surgical procedures can restore mobility for many patients with age-related musculoskeletal injuries or degenerative diseases.'], ['Chronic degenerative diseases are the leading causes of death in developed countries.', 'Mutations in mitochondrial DNA increase the number of oxidative phosphorylation-defective cells, especially in energy-requiring postmitotic tissues such as brain, heart and skeletal muscle, thereby playing an important role in aging and a variety of chronic degenerative diseases.', 'Therefore, these molecular dosimeters can be used as biomarkers in the prevention of chronic degenerative diseases, pursued either by avoiding exposure to adduct-forming agents or by using chemopreventive agents.'], ["To investigate the role of AGEs in Pick's disease, another neurodegenerative disease associated with dementia, we examined the AGE-immunoreaction in Pick's bodies and ballooned neurons, two characteristic neuropathological features of Pick's disease, using antibodies against identified AGE-structures, N epsilon-(carboxymethyl)lysine and pentosidine."], ['Thus, changes in AE structure are likely to contribute to loss of neuron homeostasis during aging and in neurodegenerative diseases.'], ["In this study HDB-type spheroids were found in high incidence in the AD cases, but only two HDB-type spheroids were seen in one case of Pick's disease, and none in any of the other cases of neurodegenerative diseases or in the elderly non-demented controls."], ["There is increasing evidence for a role of defects of mitochondrial DNA in the etiology of neurodegenerative disorders such as Parkinson's and Alzheimer's disease as well as in normal aging."], ["The precautions should extent to other populations especially susceptible to suffer from DIP, such as the elderly or patients with other neurodegenerative disorders, such as Alzheimer's disease."], ["It is proposed that measurement of the rate of atrophy in asymptomatic individuals may be a predictor of Alzheimer's disease and could be used to monitor the effectiveness of therapies designed to retard the rate of neurodegeneration."], ["Growing evidence has indicated the existence of deleterious networks in the brains of neurodegenerative disorders, including Alzheimer's disease.", 'Based on the novel concept, deleterious network, a unifying hypothesis, the deleterious network hypothesis of neurodegenerative diseases, is proposed.', 'This new theory stresses that the deleterious network is just the common pathway of the degenerative disorders, triggering of which by aging, certain genetic or environmental factors leads to a cascade of pathological alterations of the illnesses.', 'It appears that this new theory has synthesized some most appealing hypotheses about neurodegenerative illnesses, providing consistent explanations to a larger number of observations about those diseases than other hypotheses.', 'Because the disorders appear to result from the interactions among the key detrimental factors, it is suggested that the patients of the neurodegenerative diseases should be treated by combinative application of the drugs which can diminish peroxidative damage, calcium mismetabolism, and metabolic compromise.'], ['We investigated the association of non-insulin-dependent (Type 2) diabetes mellitus and depression symptoms in a representative community-dwelling elderly population independently of other conditions such as gender, age, status, disability, cognitive impairment and a number of chronic medical conditions such as chronic obstructive lung disease, degenerative joint disease, heart disease, cirrhosis of the liver, cholelithiasis, peptic ulcer and kidney stones.', 'In multiple linear regression analysis, diabetes mellitus was found to be significantly associated with depression independently of age, gender, loneliness, cognitive impairment, chronic obstructive lung disease, degenerative joint disease, heart diseases, cancer, kidney disease, cirrhosis of the liver and cholelithiasis.'], ['The accumulation of mitochondrial DNA (mtDNA) mutations has been suggested to be an important contributor to human aging and degenerative diseases.'], ['Distinct patterns of age-related alterations in NMDA (MK801 binding) and non-NMDA, AMPA (CNQX), and kainate binding have been identified in human hippocampus and parahippocampal gyrus in normal individuals with no evidence of degenerative brain disease ranging in age from 24 gestational weeks to 94 years.', 'The absence of substantial changes in any subtype examined from middle to old age suggests alterations in transmitter binding to these glutamate receptors are not involved in senescent neurodegeneration.'], ['Lipid peroxidation has been postulated as a cause of neuronal damage in both aging and neurodegenerative disease.', 'In studies of neurodegenerative disease, iron, iron plus ascorbate, or ascorbate alone has been used to stimulate lipid peroxidation.'], ['Accumulation of various mutations in the mitochondrial genome is proposed as an important contributor to aging and degenerative diseases.'], ['OBJECTIVE: It has recently been proposed that increased oxidative stress may play a role in the aging process and age-associated degenerative diseases.'], ['Ataxia telangiectasia (AT) is characterized by neurological deterioration, immunodeficiency, spontaneous chromosomal instability, hypersensitivity to ionizing radiation, predisposition to cancer, particularly T cell leukaemia and lymphoma, and premature ageing.'], ['RESULTS: With the exception of impaired vibration sense (beta = .009, P < .01), loss of upward gaze (beta = .005, P < .01), and bradykinesia (beta = .005, P < .01), all signs were associated with the neurodegenerative syndromes and stroke.', 'CONCLUSION: It is not aging to which many neurological signs should be attributed, but rather to the neurodegenerative syndromes that accompany aging.'], ['This study may contribute, therefore, to a better understanding of the mechanisms underling the excessive loss of dopaminergic neurons in neurodegenerative diseases, such as Parkinsonism, and in the aging process.'], ['In materials from younger cadavers types I, II, IV and V collagens, fibronectin, its receptor, and laminin showed stronger expression in the degenerative lesions than in the normal portions.', 'In the sections from cadavers over the seventh decade, the immunoreaction of extracellular matrices was weak compared with the younger materials, and no increased reaction of extracellular matrices in the degenerative lesions was detected.'], ['BACKGROUND: Both epidemiologic and in vitro studies have indicated the inverse correlation between intake and/or blood concentrations of different carotenoids, retinol, and tocoferol with different chronic and degenerative disturbances (cancer, cardiovascular diseases, cataracts, aging).'], ['As a consequence, emphasis on dietary advice for selecting a nutritionally adequate diet--the primary need of children--declined, whereas emphasis on dietary advice for preventing chronic and degenerative diseases increased.'], ['Based on these findings we have assessed the influence of aging as well as the influence of neurodegeneration on cerebral hemoglobin oxygenation during mental work.', 'Our finding of a regional reduced oxygen supply during activation of brain function may be of relevance to the development and the time course of neurodegeneration.'], ["Nonenzymatic glycation of proteins by glucose leading to the formation of toxic and immunogenic advanced glycation end products (AGEs) may be a major contributor to the pathological manifestations of diabetes mellitus, aging, and, possibly, neurodegenerative diseases such as Alzheimer's."], ['METHODS: From a consecutive autopsy series, we studied 88 patients (85.2 +/- 8.1 years) without degenerative disorders other than DAT.'], ['Even broader are the consequences of mitochondrial (mt) DNA impairment, which has been associated with aging, cancer, and other degenerative diseases.'], ['Special attention is drawn to the removal of herniated discs associated with massive spondylotic degenerative changes.'], ["Idiopathic Parkinson's disease (PD) is a multifactorial neuro-degenerative disorder resulting from environmental factors acting on genetically susceptible individuals with normal aging."], ['This resulted in high levels of obesity and chronic degenerative diseases such as hypertension.'], ["Work in progress will include a variety of non-Alzheimer's dementias and possibly will further increase the value of CSF investigation in neurodegenerative disorders."], ['In some degenerative disorders no such cytopathological hallmarks have been observed; a small number is genetically determined.', "While in Alzheimer's disease (AD) mental decline is mainly related to synaptic and neuritic pathologies, other degenerative disorders show variable substrates of dementia involving different cortical and/or subcortical circuits which may or may not be superimposed by cortical Alzheimer lesions.", 'There are overlaps or suggested relationships between some neurodegenerative disorders, e.g.'], ['The aims of this study were to ascertain vertebral deformity prevalence in elderly men and women and to describe the association between bone mineral density (BMD) at the lumbar spine and femoral neck, severity of spinal degenerative disease and vertebral deformity prevalence.'], ['Physical activity positively influences most structural components of the musculoskeletal system that are related to functional capabilities and the risk of degenerative diseases.'], ['Recent data from neuronal tissue culture support the contribution of the beta-amyloid peptide (beta A) to neurodegeneration in AD, probably by disruption of the intracellular Ca2+ regulation.'], ["Decline in this neurotransmitter receptor is also observed in neurodegenerative disorders, such as Huntington's disease and late-stage Parkinson's disease.", 'These results demonstrate the potential of gene therapy using adenoviral vectors to transfer neurotransmitter receptor proteins to the brain to reverse deficiencies in specific neurodegenerative disorders.'], ["The other important use for CDP-choline is in the treatment of senile cognitive impairment, which is secondary to degenerative diseases (e.g., Alzheimer's disease) and to chronic cerebral vascular disease."], ['Sixty-five patients who underwent wide laminectomy, Cotrel-Dubousset instrumentation, and fusion for lumbar degenerative disorders were reviewed radiographically to investigate the incidence and contributing factors of the postfusion instability at the adjacent segments immediately above or below the level of fusion.'], ['DISH can coexist with other articular diseases, such as degenerative joint disease and rheumatoid arthritis, or can be complicated with myelopathy and fracture.'], ["These bodies are observed more frequently in the elderly and in a number of neurodegenerative diseases including Alzheimer's disease."], ['The role of age-related metabolic acidosis in the pathogenesis of the degenerative diseases of aging warrants consideration.'], ['Neurofilamentous changes in select groups of neurons are associated with the degenerative changes of many human age-related neurodegenerative diseases.'], ['RESULTS: Among the spectrum of rheumatologic disorders frequently encountered in the elderly population are polymyalgia rheumatica, fibromyalgia, giant cell arteritis, crystalline arthropathies (gout and pseudogout), and degenerative joint disease.'], ['Thus, chronic neurodegeneration in AD-affected brain regions may be mediated in part by the ability of A beta to exacerbate inflammatory pathways in a conformation-dependent manner.'], ["It remains to be seen whether the models relevant to APP mutation FAD can be applied to Alzheimer's disease of old age, or indeed other degenerative diseases of later life."], ['OBJECTIVE: To describe the relationship between spinal degenerative disease and bone density in the elderly both cross sectionally and longitudinally.', 'RESULTS: Spinal degenerative disease, of varying severity, was common in this population (osteophytes 69%, disc narrowing 67%, posterior element disease 99%).', 'In comparison, severity of spinal degenerative disease had only a modest but significant relationship with femoral neck bone density in both sexes, but not its rate of change.', 'CONCLUSION: Spinal bone density measurement and its sequential followup may be erroneous in the elderly due to concomitant degenerative disease.', 'Bone density at the femoral neck was much less affected by spinal degenerative disease, which suggests that this site may be more efficacious for both monitoring response to treatment and determining fracture risk in the elderly.'], ['Among 35 Japanese specimens, 23 (66%) were found to have completely normal joint surfaces, 5 (14%) had chondromalacia limited to the dorsal surfaces, 2 (6%) had chondromalacia on the volar surfaces, and 5 (14%) exhibited eburnation consistent with advanced degenerative disease.'], ['PURPOSE: Reactive oxygen intermediates have been implicated in the aging process and degenerative diseases of the eye, including retinopathy of prematurity, cataractogenesis, and macular degeneration.'], ['Recent studies have centered on their kinetic mechanism, their unique predilection for substrates related to the neurotoxic tertiary amine MPTP, and their putative role in aging and in the etiology of neurodegenerative diseases.'], ['To further investigate this hypothesis, we studied the expression of another proliferation-associated antigen, Ki-67, in the brains of patients with AD and other neurodegenerative disorders.', 'Our findings suggest that Ki-67 may be involved in the pathogenesis of neurofibrillary degeneration in AD, other neurodegenerative disorders, normal aging, and neoplasms such as ganglioglioma.'], ['We are an aging society and current demographic trends point to a likely increase in age-related neurodegenerative diseases.', 'The roles of oxidative stress, mitochondrial energy metabolism, and disruption of calcium homeostasis were discussed in relation to excitoxicity and several experimental models of human neurodegenerative diseases.', 'The neurotoxic actions of kainic acid, 3-nitropropionic acid, cyanide, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, and methamphetamine were examined for their relevance as models of human neurodegenerative disorders.', 'The interrelationships among the aging process, the pathophysiology of neurodegenerative diseases, and the mechanism of action of various neurotoxins were addressed from the unifying perspective of the excitotoxic hypothesis of neuronal death.'], ['The authors conclude that (1) the state of the bone-cement interface as seen on the early postoperative radiograph can predict the longevity of a cemented socket with a high degree of probability, and that (2) cementation of an all-polyethylene socket using modern cement technique is an excellent method of fixation for patients 60 years of age and older with degenerative joint disease.'], ['The etiology of neurodegenerative diseases remains enigmatic; however, evidence for defects in energy metabolism, excitotoxicity, and for oxidative damage is increasingly compelling.', 'This may contribute to the delayed onset and age dependence of neurodegenerative diseases.'], ['These accelerated somatic mutations are expressed as premature ageing of the patients with degenerative diseases.'], ['This present work confirms that the microcebe is a good model for studying disfunctions involved in the normal cerebral aging and in some neurodegenerative disorders which affect humans.'], ['In recent years, a variety of chronic degenerative diseases that mainly involve brain, heart and muscle have been shown to result from mutations in mitochondrial DNA (mtDNA).'], ['These results may be relevant to our understanding of selective vulnerability of neuronal systems within the human hippocampal formation in aging and in neurodegenerative diseases.'], ['This review focuses on mutations of mitochondrial DNA (mtDNA) which are an important cause of mitochondrial disorders in humans and are also associated with common neurodegenerative disorders and aging.'], ['DNA repair is an important molecular defense system against agents that cause cancer, degenerative diseases, and aging.'], ["Finally, we suggest that maintenance therapy trials should be extended in several directions: (a) long-term treatment of bipolar and delusional subtypes in the elderly, as well as depression associated with progressive neurodegenerative disorders such as Alzheimer's dementia; (b) assessment of the benefits and risks of long-term therapy with other than tricyclic and monoamine oxidase inhibitor antidepressant agents, such as selective serotonin reuptake inhibitors; and (c) development of models of long-term course, including the interaction of treatments with medical and psychosocial variables that can have a profound impact on illness onset and offset."], ['It has recently been suggested that mitochondrial DNA (mtDNA) mutations are important contributors to human ageing and degenerative diseases.'], ['Abnormalities in the cellular regulation and expression of antioxidant enzymes may have a role in mechanisms of central nervous system aging and neurodegeneration.'], ['The findings provide evidence of a capacity for neuronal plasticity in the elderly human brain, even in the presence of neurodegenerative disorders.'], ["PURPOSE: Increased immunoreactivity (IR) of beta-amyloid and the amyloid-associated proteins tau and amyloid precursor protein (APP) in the brain have been linked to the pathogenesis of neurodegenerative disorders such as Alzheimer's disease."], ['Therefore, other pathophysiological mechanisms different from the cytoskeletal compromise occurring in some neurodegenerative diseases should be involved in aging.'], ['The two chief causes, vascular ectasia and diverticulosis, are degenerative diseases usually found in the elderly.'], ['The accumulation of mitochondrial DNA (mtDNA) mutations has been suggested to be an important contributor to human aging and degenerative diseases.'], ['Alternative diagnostic considerations include neurodegenerative illnesses such as AD, cerebral infarction, neoplasm, and other forms of white matter pathology such as those due to infection, inflammation, a primary demyelinative condition, or metabolic leukodystrophy.'], ['Biological rhythms in blood variables are now fairly well documented in young healthy adults whereas reports in elderly subjects are few for obvious reasons including the difficulty of setting up a group of elderly subjects comparable in age and social background and moreover free of major liver, heart, kidney, bone or any other degenerative disease and consequently not requiring medication.'], ["Neurofibrillary tangles are observed in several neurodegenerative disorders including Alzheimer's disease, progressive supranuclear palsy, and amyotrophic lateral sclerosis/parkinsonism-dementia complex of Guam.", "To investigate whether tau proteins differ biochemically among various neurodegenerative disorders, we analyzed a series of brain samples from Guamanian patients in comparison with Alzheimer's disease, progressive supranuclear palsy, and normal aging."], ['The association of APP mutation with certain familial types of AD strongly suggests that there might be a link between aberrant APP metabolism, protein phosphorylation cascades and the eventual expression of AD pathology (plaques and tangles) and neurodegeneration.'], ['Reactive oxygen species are generated physiologically in cells with a significant increase in certain pathological conditions, such as inflammation, cancer, aging, degenerative disease.'], ['Evidence is accumulating that most of the degenerative diseases that afflict humanity have their origin in deleterious free radical reactions.'], ['These cytoskeletal alterations closely resemble the cell-type-specific alterations in neurofilaments that occur during normal human aging and in diseases associated with aging, indicating that these transgenic animals may serve as models of some aspects of the pathologic features of human neurodegenerative diseases.'], ['Antioxidants have been linked to protection against degenerative diseases associated with aging.'], ["The diagnosis of Alzheimer's disease (AD) neurodegeneration is based on histopathological detection of paired helical filament-associated lesions."], ['The research summarized below collectively suggest that SOD plays an important role in longevity and degenerative disease, but much remains to be learned before manipulation of SOD expression can be considered for effective intervention in either process.'], ['Oxidative damage to DNA may play a role in both normal aging and in neurodegenerative diseases.'], ['All methods have been applied to patients with neurologic, neurosurgical, and psychiatric disease and have provided a rapidly expanding knowledge of the pathophysiology of diseases such as epilepsy, cerebrovascular disease, neoplasms, neurodegenerative diseases, mental illness, and addiction states.'], ['We have studied the immunohistochemical expression of bcl-2 protein in the aged brain and in various human neurodegenerative diseases.'], ["Aging is a major risk factor for several common neurodegenerative diseases, including Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS), Alzheimer's disease (AD), and Huntington's disease (HD).", 'Recent studies have implicated mitochondrial dysfunction and oxidative stress in the aging process and also in the pathogenesis of neurodegenerative diseases.', 'The age-related onset and progressive course of these neurodegenerative diseases may be due to a cycling process between impaired energy metabolism and oxidative stress.'], ['In humans, anecdotal observations have suggested relationships between certain recreational activities and degenerative joint disease.'], ['This could be explained by the existence of at least 2 subgroups of late paranoid psychosis: late-onset schizophrenia and organic paranoid syndrome, the former characterized by first-rank symptoms and less severe brain atrophy, the latter by more severe EEG and CT scan changes with a closer resemblance to degenerative brain disease.'], ['In particular, idazoxan has putative therapeutic effects in patients with a neurodegenerative disorder, namely dementia of frontal type.'], ['In this context, the analysis of the iron-binding protein distribution in the brains of patients affected by neurodegenerative disorders is of particular interest.', 'It is possible that in these neurodegenerative disorders affected neurons either take up or synthesize lactotransferrin to an abnormally elevated rate.'], ['Levels of glial fibrillary acidic protein (GFAP), an astrocyte-specific intermediate filament protein, are altered during development and aging, GFAP also responds dynamically to neurodegenerative lesions.'], ["Deficits of brain nicotinic receptors have been traced in neurodegenerative disorders as Alzheimer's disease and Parkinson's disease."], ["In a neurodegenerative disease, Alzheimer's disease, the situation is reversed with decreased levels of dolichol and increased levels of ubiquinone."], ['CONCLUSION: Degenerative disorders of the lumbar spine in patients over 70 year old can be treated with no anesthetic complications and with 2-year results on par with those of decompressive surgery in younger patients.'], ['Age-related degenerative valve diseases were prominent; senile dystrophic calcification with aortic stenosis mostly in the elderly, anuloaortic ectasia with aortic incompetence mostly in adults, and floppy valve with mitral incompetence in both age groups.', 'Our findings suggest that although age-related degenerative valve diseases are increasing, rheumatic disease still remains the leading cause of valve dysfunction in our country even in the elderly.'], ['Finally, the recent revolution in the study of mitochondrial diseases may further our understanding of other degenerative disorders and even aging.'], ['L-deprenyl is a monoamine-enhancing drug which at low doses selectively inhibits MAO-B, an enzyme whose brain activity has been reported to increase in normal aging and neurodegenerative dementing disorders.'], ['Aging and age-associated neurodegenerative diseases have been proposed to be the result of changes in a in anti-oxidant status and in the production of reactive oxygen species.', 'Preclinical models of these conditions and of cerebral ischemia demonstrate the primary role of protein oxidation in the initial steps of these neurodegenerative diseases.'], ['Articular cartilage from mature animals often develops osteoarthritic degenerative lesions, thus the induction of cell proliferation and of matrix synthesis may be an indication of a tissue repair process in cartilage from maturing animals.'], ['It is concluded that this model is a good tool for in vivo study of the cellular events characteristic for this human neurodegenerative disorder.'], ["Research on Parkinson's disease has led to new hypotheses concerning the mechanisms of neurodegeneration and to the development of neuroprotective agents."], ["Finally, PHF-Tau are powerful biochemical markers of the degenerating process which could be used for setting up an early biological diagnosis test of Alzheimer's disease based upon the immunodetection of PHF antigens in the CSF, as well as for developing experimental models of neurodegeneration."], ['Mitochondrial DNA (mtDNA) mutations have recently been proposed as important contributors to ageing and degenerative diseases.'], ['Cerebral amyloid angiopathy is observed in several brain degenerative disorders, but this pathological condition has received little attention in Gerstmann-Straussler-Scheinker disease (GSS).'], ['Certainly, free radical damage has been implicated in a number of neurodegenerative disorders.'], ['Ames, Shigenaga, and Hagen recently published a thorough review of the relationship between oxidants, antioxidants, and degenerative diseases of ageing.'], ["The nonreplicating adult neuron almost never undergoes tumorigenesis compared with glial cells but gives rise to a variety of age-related degenerative diseases such as Alzheimer's or Parkinson's disease."], ['The examination of middle-aged women specialist teachers of physical education, who have undertaken habitual physical activity over many years, demonstrated a lower prevalence of osteoarthrosis in the knee joints, a greater prevalence of degenerative joint disease in the lumbar spine and a similar prevalence of osteoarthrosis in the hips, compared with a closely age-matched group.'], ['The possible role for mitochondrial deficiencies in certain neurodegenerative diseases and in the ageing process have given additional momentum to research in this area.'], ['Oxidative DNA damage has been implicated in aging, carcinogenesis and other degenerative diseases.'], ['It is possible that such damage may contribute to age-dependent increases in incidence of neurodegenerative diseases.'], ['and O2.- which follows aerobic metabolism is highly enhanced in aging, alcohol consumption and in a variety of degenerative diseases including neoplasias.'], ['From sexual maturity to old age, the mammalian immune system undergoes progressive changes, some of which may predispose individuals to infectious, neoplastic and degenerative diseases.'], ['In order to clarify the sites of predilection for foamy spheroid bodies (FSBs) their regional distribution was studied in 56 persons (30-98 years) without neurodegenerative diseases.'], ["Such a precise determination is currently not possible in individuals with cerebrovascular accidents or other forms of brain injury (e.g., trauma) or degenerative brain disease (e.g., Parkinson's disease)."], ['INTERVENTIONS: The study involved the measurement of the effects of usual treatment for cataracts and other degenerative eye diseases.'], ['Many chronic degenerative diseases, which begin in middle age, are associated with peripheral vascular disease.'], ['Other neurodegenerative disorders associated with dementia were also not identified.'], ['Damage to mitochondrial DNA seems to be involved in the etiology of age-associated degenerative diseases.'], ['It is hypothesized that extension of these microfractures beyond the calcified layer mediates remodeling of the osteochondral junction in aging and degenerative joint disease.'], ['Neuropsychological studies of declining cognitive ability and increasing psychopathology in degenerative neurological diseases in the elderly suggest the following: (1) the physiological basis for affective and thought disorder remains elusive; (2) cognitive capacity and primary psychopathology are not clearly related in degenerative disease; rather neuropsychological studies in this area illustrate a dissociation between accessory (secondary) symptoms of psychopathology and cognitive changes; (3) accessory symptoms of thought disorder may be associated with disorders of the basal ganglia; and (4) current nosology of affective and thought disorders is probably not appropriate when dealing with onset of psychopathology in the elderly.'], ['These results provide evidence that reactive gliosis in this neurodegenerative disorder encompasses some degree of astrocyte hyperplasia in addition to astrocyte hypertrophy.'], ['As patients survive to advanced age, they commonly develop degenerative valvular heart disease as well as degenerative diseases of other organ systems.'], ["Neurodegenerative disorders, such as Alzheimer's disease, are characterized by losses in this type of receptor."], ['CB was lower in most nerve cells in patients than in controls, but markedly increased at the sites of intracellular neurofibrillary tangles (NFTs) and degenerative neurites and/or dendrites in and outside senile plaques (SPs), indicating its close involvement in the metabolisms of various proteins in NFT and SPs.'], ['As neurotoxins, they are believed to be involved in the pathogenesis of a variety of neurodegenerative disorders in which cognition is impaired.'], ['This endogenous DNA damage appears to be a major contributor to aging and to the degenerative diseases associated with aging such as cancer.'], ['Oxidative DNA damage may be implicated in ageing, carcinogenesis and other degenerative diseases.', 'The apparent 7-fold individual variation in oxidative DNA damage carries implications regarding the rate of ageing and the risk of cancer and other degenerative diseases.'], ['Subjective evaluation of the consecutive x-ray films revealed few new degenerative abnormalities.'], ['The accumulation of DNA damage might lead to changes in the expression of genes important for cell survival and, as such, could be a relevant risk factor in the etiology of various age-related diseases, including neurodegenerative diseases.'], ['Reactive oxygen species have been implicated both in the ageing process and in degenerative diseases, including arthritis and cancer.'], ['Particular emphasis is given to diseases related to mitochondrial DNA mutations, a field now encompassing myopathic and encephalopathic syndromes, some more common degenerative disorders, and certain aspects of the aging process.'], ['The present study underlines several aspects of the organization of the neuropeptide-containing neurons of the human cerebral cortex, which are of particular interest in the light of the involvement of these neurons in several neurodegenerative diseases.'], ['Often the main determinant in selecting food is a desire for a healthful diet that will foster longevity and prevent the devastating consequences of chronic degenerative disease.'], ['They often occur in association with the degenerative diseases that are likely to affect this age-group.'], ['Since early signs of chronic degenerative diseases of aging have been seen in autopsies of children, efforts should be made to ensure that prolonged low intakes of vitamin E are avoided in children as well as adults.'], ['The current knowledge of PAF and its role in cardiovascular disease, thromboembolism, cerebral ischaemia and neurodegenerative disorders are discussed in detail.'], ['The indication for surgery was degenerative joint disease (DJD) in one half of the patients and complications to proximal femoral fractures in the other half.', 'There was a lower dislocation rate (4/84) in the DJD group compared to the fracture group (11/78).'], ["During the last decade the importance of reactive oxygen species as major contributors to various types of cancer, heart diseases, cataracts, Parkinson's and other degenerative diseases that come with age, and to natural aging has become apparent."], ['At higher levels of biological organization, this will lead to a loss in the bioenergetic capacity of cells, with concomitant decreases in ATP dependent protein synthesis and specialized physiological function, thus paving the way for age related degenerative diseases.'], ['Defects of the respiratory chain are increasingly recognised as important causes of human disease, and neurodegenerative disorders in particular.'], ['Finally we describe data on the effect of degenerative diseases on the serotonin system and the possible link to increased suicidal behavior in affected patients.'], ['RESULTS: Similarities among non-Japanese and Japanese cases included: (1) male predominance; (2) peak age at onset of symptoms in the sixth decade; (3) clinical presentation, which ranged from asymptomatic to quadriplegia, with progressive or acute onset of neurologic deterioration; (4) greater than 95% localization to the cervical spine, spastic quadriparesis being the most common neurologic presentation; (5) an association with several rheumatic conditions including diffuse idiopathic skeletal hyperostosis (DISH), spondylosis, and ankylosing spondylitis; and (6) neurologic improvement with either conservative or surgical treatment in a significant proportion of patients.'], ['Increased CuZnSOD activity in these age-related neurodegenerative disorders might result in H2O2 overproduction and subsequently promote peroxidative damages within cells.'], ['A growing body of evidence shows that oxygen radicals and other products of free radical reactions are involved in aging and age-related degenerative diseases.'], ['A process comparable to early stages in petite mutagensis occurs in human degenerative diseases and it seems possible that a consequence of exposure to petite mutagens could be an increase in the rate of degenerative diseases or of the aging process.'], ['The project aims at determining how aging influences nutritional status (as determined by measurements and indicators from clinical evaluation, anthropometric, laboratory, and biophysical tests) in a Chronic degenerative disease burden; 5) Use of drugs and medications (both Western and traditional) and 6) physical activity as the direct mediators of nutritional status of the elderly.'], ['The theory may provide the basis for a practical approach for reduction of degenerative diseases in general, extension of life expectancy, and optimization of individual lifestyles.'], ['If some chronic degenerative diseases will be eliminated or will be put at least under control then life expectancy at birth can be as high as 84.3 years.'], ['As infectious diseases decline as causes of mortality, certain degenerative diseases including cardiovascular disease and cancer account for an increasing percentage of deaths.'], ['It is argued that this endogenous DNA damage is a major contributor to aging and the degenerative diseases of aging, such as cancer.', 'It is argued that deficiency of micronutrients, such as dietary antioxidants or folate, is a major contributor to human cancer and degenerative diseases.'], ['The empirical use of these techniques for the extension of human life-span and diminution of human suffering from degenerative diseases is discussed.'], ['The assumption that dementia is a product of normal aging or a functional psychotic disorder of late life was first challenged by Corsellis, who found a strong correlation between the severity of cerebral degenerative change and clinical diagnosis of patients who died in a psychiatric hospital.'], ['These neurites were present in all 11 AD cases, 11 of 14 subjects with other neurodegenerative diseases, and 6 of 8 neurologically normal adult controls, but no dystrophic neurites were seen in 9 fetal and neonatal cases.'], ['Free-radical-mediated pathology has been implicated in the development over time of degenerative diseases and conditions.'], ['Wallerian degeneration might be another cause of leuko-araiosis in neuro-degenerative disorders beside previously reported extra-cerebral predisposing factors and amyloid angiopathy.'], ["The activity of the superoxide dismutase was measured by the polarographic method of catalytic currents in the cerebrospinal fluid of patients with age-related neurologic degenerative diseases, namely, amyotrophic lateral sclerosis and Alzheimer's disease, and of a reference group of normal subjects.", 'The activity mean values were significantly lower (P less than 0.01) in patients with neurologic degenerative diseases than in the reference subjects.', 'The changes of superoxide dismutase activity in the aging brain and in age-related neurologic degenerative diseases are discussed.'], ['Considerations and injuries to the masters-level swimmer closely mirror those found in the younger athlete, but these injuries reflect the impact of tissue aging (degenerative disease).'], ['Corpora amylacea (CA) are one of the conspicuous features of brain tissue in normal aging and neurodegenerative diseases.'], ['In human osteoarthritis and animal models of degenerative joint disease, damage to the structure of cartilage proteoglycan is a central event.'], ['Given that hypothetical cures for major degenerative diseases would reduce overall mortality by 75%, it seems highly unlikely that life expectancy at birth will exceed the age of 85.'], ['However, other degenerative diseases involving several cardiac structures exist, and should be distinguished from age-related cardiac changes.'], ['In humans, anecdotal observations have suggested relationships between recreational activities and degenerative joint disease.'], ['A consequence of the accumulation of this deletion could be a progressive decrease with age of bioenergetic capacity which in turn could influence the rate of ageing and predispose to age-associated degenerative diseases.'], ['The systematic search for etiological factors and mechanisms of pathogenesis of neurodegenerative disorders is perhaps nowhere better exemplified than in the western Pacific.', 'During the past three decades, the opportunistic and multidisciplinary study of hyperendemic foci of amyotrophic lateral sclerosis and parkinsonism-dementia which occur in different cultures, in different ecological zones and among genetically divergent populations have served as natural models that have had a major impact on our thinking and enhanced our understanding of these and other neurodegenerative disorders such as Alzheimer disease and the process of early neuronal aging.', 'These studies clearly demonstrate the philosophy that chronic rather than acute experimental models of toxicity are necessary in order to enhance our understanding of human neurodegenerative disorders with long-latency and slow progression.'], ['For each clinical category, the annual death rate remained constant throughout the observation period, indicating the effects of a steadily progressing degenerative disorder.'], ["These data suggest that (a) ALE is common in old age and is probably the cause of leuko-araiosis in most CT scans in the elderly; (b) ALE may be asymptomatic; (c) the severity of white matter changes may be not related to the severity of neurological deficits; and (d) multiple lacunar infarcts or associated degenerative diseases (i.e., Alzheimer's disease) may be the main cause of dementia in patients with ALE."], ['In view of (i) the increasing proportion of older individuals within technically advanced populations together with the need of this group for health care and (ii) the important role played by diet and food habits in health maintenance, and in the aetiology or progression of degenerative disease, it is vitally necessary to improve upon the current state of knowledge concerning protein and amino acid metabolism and nutrition during the later phases of our lives.'], ["Neither the clinical nor the neuropathological features of this group are typical of Parkinson's or Alzheimer's disease, but suggest a distinct neurodegenerative disorder, part of the Lewy body disease spectrum, in which mental symptoms predominate over motor disabilities and lead to eventual psychogeriatric hospital admission."], ['The present studies establish that there are specific, significant decreases in the neuronal calcium-binding protein (28-kDa calbindin-D) gene expression in aging and in neurodegenerative diseases.', 'Since calbindin gene expression decreased specifically in brain areas known to be particularly affected in aging and in each of the neurodegenerative diseases, these findings suggest that decreased calbindin gene expression may lead to a failure of calcium buffering or intraneuronal calcium homeostasis, which contributes to calcium-mediated cytotoxic events during aging and in the pathogenesis of neurodegenerative diseases.'], ["Deposition of amyloid (A4) protein was assessed in the cerebral cortex of 26 patients dying with various neurodegenerative disorders, other than Alzheimer's disease."], ['Physical dependency, mental disorder and degenerative disease, lack of spouse, being white, poverty, old age, unoccupied nursing home beds, and climate all appear to be determinants of institutional residency among the aged.'], ['The mild, chronic renal failure of aging, and the consequent secondary hyperparathyroidism, might therefore contribute to the development of nervous degenerative diseases.'], ['There was no evidence of either neurodegenerative or premature aging processes.'], ['The therapeutic usefulness of nimodipine appears not to be limited to cerebral ischemia, but may include dementia, age-related degenerative diseases, epilepsy, and ethanol intoxication.'], ['It is proposed that the accumulation of mitochondrial mutations and the subsequent cytoplasmic segregation of these mutations during life is an important contributor both to the ageing process and to several human degenerative diseases.'], ['The results indicate that cytochrome-c-oxidase deficient heart muscle cells represent a degenerative lesion associated with cellular ageing and may be involved in the reduction of myocardial contractile ability in senescence.'], ['Results will be presented, which have been obtained by analysis of age-related events in inbred mice, where regulation, involved in degenerative disease of old age, can be studied in groups of individuals with a relatively constant genetic background.', 'It should be possible to identify appropriate probes for degenerative diseases of old age that can be used for detection of corresponding human genes.', 'To respond to this need, we should learn how to identify individuals at risk from degenerative diseases of old age and how to treat them preventively.'], ['We therefore put forward the hypothesis that key mechanisms which normally control the development and plasticity of neural circuitry, are also involved in neurodegeneration.', 'When intracellular calcium levels are not regulated within normal limits, as may occur in aging, neurodegeneration may occur.'], ['The involvement of NGF in human neurodegenerative diseases is not established but the application of NGF to degenerating cholinergic neurons in Alzheimer patients may prove useful.'], ["Alzheimer's disease is a neurodegenerative disorder characterized by global cognitive decline.", "While tangles appear to be a universal hallmark of dying neurons in several neurodegenerative diseases, amyloid plaques occur in only three conditions including Alzheimer's disease, Down syndrome, and to a limited extent, normal aging."], ['Osteoarthritis (degenerative joint disease) is almost always present to some degree in persons over 60 years of age.'], ['Acute illnesses, particularly respiratory problems, accounted for the majority of geriatric admissions although chronic degenerative disorders, usually cardio-vascular in nature, also played a role.'], ['The anti-human PrP antiserum reacted with the plaques in CJD and GSS, with or without degenerative neurites (neuritic components).'], ['Nabumetone, a nonsteroidal anti-inflammatory drug of the naphthylalkanone class, was studied in an open-label fashion to compare the relative single-dose and steady-state kinetics in young healthy male volunteers and in elderly patients with degenerative joint disease.'], ['Severe degenerative joint disease and metatarsus primus varus with fair to good bone stock are the major criteria.'], ['Incorrect diagnoses included diabetes mellitus, osteoarthritis, degenerative spinal disease, gait disturbance secondary to fall and a thalamic cerebrovascular accident.'], ['The presence of degenerative disease, multiple pathology, and diminished psychological reserve pose greater demands on technical surgical skill and clinical judgment.'], ['Partial cell loss occurs during the course of aging, neurodegenerative diseases, and minor traumatic brain injuries.', "The observation that sprouting also occurs in Alzheimer's disease illustrates that a slow and fractional loss of a neuronal assembly can trigger reactive growth in humans even along with a severe neurodegenerative disease."], ['Once the signs of normal aging are recognized, findings that indicate aging alone can be separated from those that clearly suggest a focal neurologic lesion.'], ['Four initially alert patients suffered neurological deterioration associated with the performance of lumbar puncture, which corresponds to a complication rate of 2.2%.'], ['Thus, mitral valve prolapse and, in the elderly, degenerative lesions have displaced rheumatic and congenital heart diseases as the major conditions underlying endocarditis.'], ['A very important but as yet unanswered concern is whether regular exercise will lead to degenerative joint disease or osteoarthritis.', 'Anecdotal observations in man have suggested relationships between recreational activities and degenerative joint disease.'], ['Pain in the head and neck region is a common symptom in elderly people, with degenerative disease and neoplasms being the most frequent causes.'], ['The clinical, angiographic, macroscopic, and histopathologic characteristics of RDPE and its correlation with macular degenerative abnormalities in the autopsy and clinical eyes are presented.', 'Evaluation of the peripheral fundus is of value in assessing patients with macular degenerative abnormalities.'], ['Degenerative joint disease (DJD) at the hip and spine was scored, and loss of passive joint mobility at the hip was measured.', 'Development of DJD at both the hip and spine was significantly and positively correlated with age.', 'In some individuals, DJD was observed soon after the completion of growth, but pronounced changes seldom occurred before the middle of the second decade of life.'], ['Human chondrocytes isolated from cartilage with moderate to severe osteoarthritis synthesize at least 1 of these stress proteins (Mr 70,000) at physiologic temperature (37 degrees C), whereas chondrocytes isolated from non-pathologic cartilage synthesize this protein only in response to incubation at temperatures above 39 degrees C. The active synthesis of this protein (SP-70) at 37 degrees C is positively correlated with the severity of osteoarthritis and can be a characteristic indicator of this degenerative disease.'], ['Prosthetic valves and degenerative heart disease will undoubtedly become increasingly important underlying heart lesions in patients with endocarditis.'], ['The role of dietary manipulations in the prevention and treatment of chronic degenerative disorders of later life needs further studies before satisfactory conclusions may be drawn.'], ['Inherited and degenerative diseases of the nervous system are overwhelmingly a problem of aging.'], ['In the 20th year degenerative deposits in the conjunctiva begin.', 'They increase in number and above the 60th year all subjects showed degenerative deposits.'], ['They had to execute multistep saccades typically seen in patients with degenerative neurological diseases.'], ['Longevity was greater during the second period, and a decrease in deaths due to status epilepticus was outweighed by an increase in deaths from arterial degenerative disease in the larger number of older patients.'], ['Rehabilitation of the elderly is largely concerned with the management of degenerative disorders and is often complicated by multiple pathology, low expectations (by staff rather than the patient) and social inadequacies.'], ['In addition, the ability of grafted neurons to reinnervate damaged regions of the host brain and to ameliorate some neuroendocrine deficits, cognitive disorders and motoric dysfunctions in young adult rodents has suggested that transplantation therapy may be effective in treating human neurodegenerative diseases and neurotransmitter deficiencies related to aging.'], ['The newly discovered metabolite may prove useful in future studies of dopamine autoxidation and the possibly resultant cytotoxicity in aging and degenerative brain disorders.'], ['A more marked decline is associated with degenerative joint disease.'], ['Degenerative arthropathy and rheumatoid disease produce significant morbidity in elderly dental patients.', 'This procedure may be used for degenerative arthropathy and also for chronic dislocation which has failed to respond to peri-articular injection of sclerosing agents.'], ['The scientific understanding of cancer and degenerative disease is being aided by new methodologies which are now used to approach the problem of environmental and occupational carcinogens and anticarcinogens.', 'It also discusses the use of oxygen radicals as a cause of degenerative disease associated with aging.'], ['Such models may include degenerative diseases, diseases and/or lesions associated with the aging process, and genetic diseases.', 'Three of these are bacterial diseases that currently cause severe and sometimes fatal infections in humans; one is a degenerative disease that is usually progressive and fatal in humans, and one is possibly a genetic disease for which there is currently no animal model.'], ["The extensive ramifications of these noradrenergic terminals mean that the atrophy and loss of nerve cells from locus coeruleus that occurs in old age, and especially so in degenerative diseases of the central nervous system such as Alzheimer's disease and other conditions, will have widespread repercussions for brain function."], ['The contrasts shown between hospital inpatients and old people still at home indicate the progressive consequences of physical and neurological deterioration.'], ["Canine ceroid lipofuscinosis is a degenerative neuronal disorder which has as a distinct pathologic counterpart, neuronal ceroid lipofuscinosis or Batten's disease in humans."], ['The mechanical defects of this degenerative disease render medical treatment ineffectual.'], ['Males experience higher mortality rates in both infectious and degenerative diseases.'], ["Owners should be advised of the behavioral problems that may occur secondary to degenerative diseases and also be persuaded to keep social and environmental changes to a minimum in an old animal's life."], ['The free radical theory of aging provides reasonable explanations for age-associated phenomena, including (i) the relationship of the average life spans of mammalian species to their basal metabolic rates, (ii) the clustering of degenerative diseases in the terminal part of the life span, (iii) the beneficial effect of food restriction on life span, (iv) the greater longevity of females, and (v) the increase in autoimmune manifestations with age.'], ["These findings suggest that many of these patients did not have Parkinson's disease but rather rigid-akinetic syndromes associated with degenerative brain disease."], ['An infection during old age may also be induced by another condition such as degenerative disease, catheterization, malnutrition, or another infection.'], ['Degenerative heart disease was the underlying cardiac factor in nearly half the streptococcal cases, but staphylococci most often affected normal heart valves.'], ["Old people's eating habits are often idiosyncratic and unhealthy; their feeding can reflect such brain disease are dementia, depression, paranoia; poor nutrition can contribute to degenerative brain disease."], ["Fifty unselected institutionalized patients with Down's syndrome were studied to determine the clinical course of precocious aging and mental and neurological deterioration."], ['Degenerative joint disease, almost universally present in the elderly, may not be the basis for the newly developing rheumatic symptoms.'], ['In dementia due to degenerative diseases, metabolic disorders, normal pressure hydrocephalus, and deficiency states, the diffuseness of the abnormalities observed has been emphasized; whereas with cerebrovascular disease and with intracranial massess, the focal nature of the changes has been stressed.'], ['When back pain is a serious symptom in the elderly patient, the physician should look beyond the obvious evidences of degenerative joint disease for these other more serious conditions.'], ['Although degenerative joint disease is a most common type of arthritis in persons past 40 years of age, and associated with an aging process, this case has been presented as an interesting finding because of the early occurrence.'], ['In the groups under study they were thought to represent old thrombi rather than degenerative lesions predisposing to thrombosis.'], ['Some of these may be of occult, degenerative or vascular central nervous system disease origin--entities which are often difficult to incriminate specifically.', 'Treatment follows conventional guidelines with some modifications due to the vulnerability of the ageing patient to degenerative disease and complications of immobilization.'], ['In younger individuals a crippling condition may affect an otherwise healthy body, while in an older person it may be superimposed on other pre-existing degenerative diseases.'], ['Our open-sourced dataset can serve as a brain region reference panel for future studies and help advance research in aging and neurodegenerative diseases.'], ['These results also suggest that NAGLU overexpression could be explored to promote healthy aging and to prevent the onset of neurodegenerative diseases, including AD.'], ['Aging is accompanied by a host of social and biological changes that correlate with behavior, cognitive health and susceptibility to neurodegenerative disease.'], ["OBJECTIVE: Positron emission tomography (PET) allows in vivo evaluation of molecular targets in neurodegenerative diseases, such as Alzheimer's disease.", 'In contrast, [18F]fluoro-2-deoxy-d-glucose (18F-FDG) is a neurodegeneration biomarker used to evaluate cerebral glucose metabolism, indicating neuronal injury and synaptic dysfunction.', 'However, early-phase 11C-PiB appears to provide different information from 18F-FDG about neurodegeneration.'], ['Immunotherapy drugs are transforming the clinical care landscape of major human diseases from cancer, to inflammatory diseases, cardiovascular diseases, neurodegenerative diseases and even aging.'], ['For example, based on the presence of wasteosomes, it seems that aging, sleep disorders, and cerebrovascular pathologies have the highest impact on the glymphatic system, whereas neurodegenerative diseases have a more limited impact.', 'Furthermore, as glymphatic insufficiency is a risk factor for neurodegenerative diseases, information provided by wasteosomes could help to define the strategies and actions that can prevent glymphatic disruptions, thus limiting the risk of developing neurodegenerative diseases.'], ["Background: Alzheimer's disease is the most common neurodegenerative disease worldwide."], ['To measure the progression of AD, we devised rapid bioassays to measure the abundance of isoform-specific Abeta prions in the brains of transgenic (Tg) mice and in postmortem human CNS samples from AD victims and people who died of other neurodegenerative diseases (NDs).'], ["Neurodegenerative diseases, such as Alzheimer's disease (AD), and their associated deterioration of cognitive function are common causes of disability.", 'The slowly developing pathology of neurodegenerative diseases necessitates early diagnosis and monitored long-term treatment.'], ['Cellular senescence plays a pivotal role in the aging and progression of neurodegenerative diseases, including vascular cognitive impairment and dementia (VCID).'], ['Intracellular aggregation of hyperphosphorylated Tau (pTau) in the brain is associated with cognitive and motor impairments, and ultimately neurodegeneration.', 'We find that pTau preferentially accumulates in deep-layer pyramidal neurons, leading to neurodegeneration, and we establish that pTau spreads to oligodendrocytes.', 'We hypothesize that unimpaired subcortical network mechanisms maintain cortical neuronal coordination, counteracting the widespread pTau aggregation, loss of high-firing cells, and neurodegeneration.'], ["Parkinson's disease (PD) is a multisystem alpha-synucleinopathic neurodegenerative disease and the most prevalent neurodegenerative disorder after Alzheimer's disease with a high incidence rate in the elderly population."], ["Alzheimer's disease (AD), is a progressive neurodegenerative disease that affects behavior, thinking, learning, and memory in elderly individuals."], ['The risk of further neurological deterioration and readmission rates were compared between these two groups.', 'There were no statistically significant differences in terms of intervention rate, risk of neurological deterioration in the future, or readmission between them.', 'CONCLUSION: Repeat head CT in mild TBI patients with no neurological deterioration is not recommended, even in patients with a higher risk of ICH progression.'], ['In addition, improvements in mobility and balance were seen in the elderly and people with neurodegenerative diseases.'], ['Alterations of serum N-glycan expression could represent essential contributors to the overall pathophysiology of neurodegenerative diseases and be used as a potential marker to assess MCI diagnosis using non-invasive procedures.', 'It is a process that plays a fundamental role in neuroinflammation, an important process in the progression of neurodegenerative diseases.'], ['Studies of blood and cerebrospinal fluid biomarkers showed that systemic inflammation, neurodegeneration, endothelial activation, oxidative stress, and iron dysregulation are associated with worse cognition in people with HIV.'], ['Furthermore, studies have shown the neuroprotective effect of alpha-Klotho against neuroinflammation on different conditions, such as aging, animal models of neurodegenerative diseases, and ischemic brain injury.'], ['Given the aging population, it is important to better understand neurodegeneration in aging healthy people and to address the increasing incidence of neurodegenerative diseases.', 'The study of sex differences in neurodegeneration can reveal new candidate treatment targets tailored for women and men.', 'Sex chromosome effects on neurodegeneration remain understudied and represent a promising frontier for discovery.', 'Here, we will review sex differences in neurodegeneration, focusing on the study of sex chromosome effects in the context of declining levels of sex hormones during aging.'], ['Tauopathies are a category of neurodegenerative diseases characterized by the presence of abnormal tau protein-containing neurofibrillary tangles (NFTs).'], ['However, identification of changes in the CP remains poorly characterized in obesity, one of the main risk factors of neurodegeneration, including in the absence of frank central nervous system alterations.'], ['BACKGROUND: Impaired cerebrospinal fluid (CSF) dynamics may contribute to the pathophysiology of neurodegenerative diseases, and play a crucial role in brain health in older people; nonetheless, such age-related changes have not been well elucidated.'], ['BACKGROUND: Knee osteoarthritis (KOA) with varus alignment and medial space stenosis is a common degenerative disorder in the elderly.'], ["Huntington's disease (HD) is an inherited neurodegenerative disorder with adult-onset clinical symptoms, but the mechanism by which aging drives the onset of neurodegeneration in patients with HD remains unclear.", 'Reducing miR-29b-3p or chemically promoting autophagy increased the resilience of HD-MSNs against neurodegeneration.'], ['Abeta pathology was measured with 18F-florbetapir-PET, and neurodegeneration was assessed with subregional volume from structural MRI.', 'Our findings suggest that Abeta may indirectly lead to memory impairment through entorhinal-hippocampal circuit dysfunction and neurodegeneration, and provide a mechanism for increased vulnerability of object mnemonic discrimination.SIGNIFICANCE STATEMENT:Mnemonic discrimination is a critical episodic memory process that is performed in the dentate gyrus (DG) and CA3 subfield of the hippocampus, relying on input from entorhinal cortex.', 'This hyperconnectivity was associated with amyloid-beta pathology and neurodegeneration in entorhinal cortex, suggesting aberrantly increased network activity is a pathologic process.'], ['One of the main issues in Western countries is represented by the challenges of aging and age-related diseases, such as neurodegenerative disorders.'], ["Neuroinflammation plays a significant role in the aging process and the pathophysiology of neurodegenerative diseases, such as Alzheimer's disease.", 'However, the majority of evidence of the beneficial effects of walnuts or their components on neuroinflammation and neurodegeneration comes from experimental work, whereas evidence from clinical studies on the beneficial effects is scarcer and less conclusive.', 'This review aims to provide new insights into the neuroinflammation-regulating mechanisms and natural active ingredients of walnuts and the development of walnut-based functional foods for the alleviation of neurodegenerative diseases.'], ['Aging is a very complex process that is accompanied by a degenerative impairment in many of the major functions of the human body over time.', 'Many external and internal signs and symptoms are related with the aging process and senescence, including skin dryness and wrinkles, atherosclerosis, diabetes, neurodegenerative disorders, cancer, etc.'], ['These up-regulated miRNAs in turn down-regulate a family of neurodegeneration-associated messenger RNA (mRNA) targets, including the mRNA encoding the neuron-specific neurofilament light (NF-L) chain protein.', 'While NF-L has been reported to be up-regulated in peripheral biofluids in AD and other progressive and lethal pro-inflammatory neurodegenerative disorders, NF-L is significantly down-regulated within neocortical neurons, and this may account for neuronal atrophy, loss of axonal caliber and alterations in neuronal cell shape, modified synaptic architecture and network deficits in neuronal signaling capacity.', 'This paper reviews and reveals the most current findings on the neurotoxic aspects of LPSs and how these pro-inflammatory glycolipids contribute to the biological mechanism of progressive, age-related and ultimately lethal neurodegenerative disorders.'], ['However, dysregulation of hippocampal neurogenesis with aging, injury, depression and neurodegenerative disease leads to debilitating cognitive impacts.', 'Impaired hippocampal neurogenesis is especially difficult to rescue with increasing age and neurodegeneration.'], ["The relevant social and economic costs associated with aging and neurodegenerative diseases, particularly Alzheimer's disease (AD), entail considerable efforts to develop effective preventive and therapeutic strategies."], ['Furthermore, we discuss how the potential for formation of iG4s in neuronal cells, triggered by repeat expansions in the C9orf72 gene, can lead to the formation of nucleic-acids based pathological aggregates in neurodegenerative diseases like ALS and FTD.'], ['FUNDING: EU Joint Programme-Neurodegenerative Disease Research grant, funded by the National Health and Medical Research Council Australia, and the US National Institute on Aging of the US National Institutes of Health.'], ['In further experiments, HL0285 improved healthspan, enhanced stress resistance, and delayed the progression of neurodegenerative diseases in C. elegans.'], ['Progressive age is the single major risk factor for neurodegenerative diseases.'], ['Histologic, transcriptome, live-imaging, and mechanistic studies reveal a previously unknown pathomechanism: Photoreceptor neurodegeneration via cell extrusion.'], ['Aging and neurodegenerative diseases lead to decline in thinking and memory ability.', 'Magnetic resonance elastography is a technique that can noninvasively image tissue viscoelastic mechanical properties, potentially serving as sensitive biomarkers of aging and neurodegeneration related to functional outcomes.'], ['Aging is the greatest risk factor for the development of neurodegenerative diseases, yet we still do not understand how the aging process leads to pathological vulnerability.', 'This work firmly establishes the marmoset as a model of age-related cognitive impairment.Significance Statement:Understanding the normal aging process is fundamental to identifying therapeutics for neurodegenerative diseases for which aging is the biggest risk factor.'], ["Mounting evidence also suggests that altered expression of Nrf2 is largely involved in aging, neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, Huntington's diseases, Amyotrophic lateral sclerosis, Stroke, Multiple sclerosis and others.", 'The purpose of this article is to detail the essential role of Nrf2 in oxidative stress, antioxidative defense, detoxification, inflammatory responses, transcription factors, proteasomal and autophagic/mitophagic degradation, and metabolism in aging and neurodegenerative diseases.', 'This article also highlights the Nrf2 structural and functional activities in healthy and disease states, and also discusses the current status of Nrf2 research and therapeutic strategies to treat aging and neurodegenerative diseases.'], ["METHODS: This was a sub-study of an ongoing prospective community cohort of China National Clinical Research Center Alzheimer's Disease and Neurodegenerative Disorder Research (CANDOR)."], ['Indeed, due to its higher bioavailability paired with reduced toxicity compared to other stilbenes, PTS has become an attractive drug candidate for the treatment of several disease conditions, including diabetes, cancer, cardiovascular disease, neurodegenerative disorders, and aging.'], ['Due to the rise in the elderly population, age-dependent neurodegenerative disorders are becoming increasingly prevalent.', 'In this review, we discuss the role of Gals in the causation and progression of neurodegenerative disorders.', 'In addition, we discuss the potential use of Gals as a novel therapeutic target for neuroinflammation and restoring tissue damage in neurodegenerative diseases.'], ['Research into assisted living environments -within the area of Ambient Assisted Living (ALL)-focuses on generating innovative technology, products, and services to provide medical treatment and rehabilitation to the elderly, with the purpose of increasing the time in which these people can live independently, whether they suffer from neurodegenerative diseases or disabilities.'], ['BACKGROUND: In the last decade, non-invasive blood-based and neurophysiological biomarkers have shown great potential for the discrimination of several neurodegenerative disorders.'], ['CHI3L1/ YKL40 is a widely investigated chitinase in neurodegenerative diseases and recent studies have shown its involvement in aging and AD.', "Here, we collected microarray datasets from the National Center for Biotechnology Information (NCBI) brain samples of not demented healthy controls (NDHC) who died from causes not attributable to neurodegenerative disorders (n = 460), and of deceased patients suffering from Alzheimer's disease (AD) (n = 697)."], ['BACKGROUND: Neurodegenerative diseases have become an important concern with the accelerated aging process.', 'The aim of this study was to summarize the protective effects of TCQ for motor function, cognition, quality of life, and mood in patients with neurodegenerative diseases.', 'CONCLUSION: TCQ exercise can effectively improve the motor function, global cognitive function, and falls in patients with neurodegenerative diseases.', 'However, the positive effects of TCQ on the quality of life and mood of patients with neurodegenerative diseases need further evidence.'], ['In fact, evidence suggests a possible disruption of the blood-brain barrier and deleterious effects on the CNS, especially in patients who already suffer from other pathologies, such as neurodegenerative disorders.', 'The molecular mechanisms behind these effects on the CNS could involve the dysregulation of mitochondrial physiology, a well-known early marker of neurodegeneration and a hallmark of aging.'], ['Recent research has also shown that irregularities in PTMs can be linked to hearing loss, including age-related hearing loss (ARHL) - the number one communication disorder and one of the top neurodegenerative diseases in our aging population.'], ['Together these results indicate that aging DPP6-KO mice show symptoms of enhanced neurodegeneration reminiscent of dementia associated with a novel structure resulting from synapse loss and neuronal death.'], ['Moreover, we observed that the degenerative neuronal lesions and aberrant behaviors were alleviated in REGgamma OE;PS19 mice.', 'This study provides valuable insights into the novel regulatory mechanisms and potential therapeutic targets for tau-related neurodegenerative diseases.'], ['Common sensory and motor changes in aging adults may be early markers of neurodegeneration.', 'We investigated if midlife sensory and motor functions in Beaver Dam Offspring Study (BOSS) participants (N = 1529) were associated with longitudinal changes in blood-based biomarkers of neurodegeneration (neurofilament light chain (NfL); total tau (TTau)) and AD (amyloid beta (Abeta)).', 'We found consistent relationships between worse baseline hearing and motor function with a faster increase in neurodegeneration, specifically serum NfL level.', 'Future studies with longer follow-up should determine if sensory and motor changes are more reflective of general neurodegeneration than AD-specific pathology and whether sensory and motor tests may be useful screening tools for neurodegeneration risk.'], ['Replication errors and various genotoxins cause DNA double-strand breaks (DSBs) where error-prone repair creates genomic mutations, most frequently focal deletions, and defective repair may lead to neurodegeneration.', 'Our analysis of 50 single neurons from DNA repair-deficient diseases with progressive neurodegeneration (Cockayne syndrome, Xeroderma pigmentosum, and Ataxia telangiectasia) reveals elevated somatic deletions compared to age-matched controls.', 'Distinctive mechanistic signatures and transcriptional associations suggest roles for somatic deletions in neurodegeneration.'], ["Asia has an enormous number of older people and is the primary contributor to the rise in neurodegenerative diseases such as Alzheimer's and Parkinson's disease.", 'The therapy of many neurodegenerative diseases has not yet progressed to the point where it is possible to alter the course of the disease.', 'These findings highlight the pivotal role of preventing and managing hypertension as a risk factor for neurodegenerative disease.', 'Autonomic dysfunction, neuropsychiatric and sleep disturbances can arise in neurodegenerative diseases, resulting in blood pressure variability (BPV).', 'In older people with neurodegenerative disease and hypertension, it is critical to consider 24-h blood pressure monitoring and personalized blood pressure therapy.'], ['Selective neuronal vulnerability (SNV) of specific neuroanatomical regions such as frontal cortex (FC) and hippocampus (HC) is characteristic of age-associated neurodegenerative diseases (NDDs), although its pathogenetic basis remains unresolved.'], ['An overarching goal of aging and age-related neurodegenerative disease research is to discover effective therapeutic strategies applicable to a broad spectrum of neurodegenerative diseases.', 'These findings uncover a previously unrecognized mechanism of Nsp1 in manipulating host translation, which can be leveraged for combating age-related neurodegenerative diseases that are affecting millions of people worldwide and currently without effective treatment.'], ['Biological sex is a factor in many conditions, including aging, neurodegenerative disease, cancer, and more.'], ["Parkinson's disease (PD) is the second most common neurodegenerative disorder, affecting millions each year."], ["Moreover, it has been demonstrated that EA can enhance neuronal viability, reduce neuronal defects, and alleviate damage in neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and cerebral ischemia."], ['Concurrent CSVD burden is more commonly observed in AD-type dementia than in other neurodegenerative diseases.'], ['The AEP-mediated cleavage of these peptides enhances amyloidosis, promotes tau hyperphosphorylation, and ultimately induces neurodegeneration and cognitive impairment.'], ["BACKGROUND: Overexposure to manganese (Mn) can lead to neurodegenerative damage, resulting in manganism with similar syndromes to Parkinson's disease (PD)."], ['Osteoarthritis (OA), a chronic degenerative joint disease, always occurred in the aging population.'], ['Blocking FSH action prevents bone loss, fat gain and neurodegeneration in mice.'], ['We related self-reported liver disease to longitudinal measures of brain structure and cognition, as well as baseline measures of plasma AD/neurodegeneration biomarkers in the Baltimore Longitudinal Study of Aging.'], ['Across the three data sets, the visualization of the smooth trajectory vector fields and superior accuracy on downstream tasks demonstrate the strength of the proposed method over existing self-supervised methods in extracting information related to brain aging, which could help study the impact of substance use and neurodegenerative disorders.'], ['METHODS: We conducted a single-center observational study, including 130 consecutive AD patients (mean age: 70.71 +- 8.50 y, 54.6% women) who attended a center for neurodegenerative diseases.'], ['INTERPRETATION: Brain-PAD was associated with cardiovascular risk, and imaging and biochemical markers of neurodegeneration.'], ["Tauopathies are a family of neurodegenerative diseases which predominately afflict the rapidly growing aging population suffering from various brain disorders including Alzheimer's disease, frontotemporal dementia with parkinsonism-17 and Pick disease.", 'As the only visually accessible region of the central nervous system, in recent years, the retina has attracted extensive attention for its potential as a target for visualizing and quantifying emerging biomarkers of neurodegenerative diseases.'], ['Importance: Decreased cerebral tissue integrity and cerebral blood flow (CBF) are features of neurodegenerative diseases.', 'This work may lay the foundation for investigations to clarify the nature of early brain damage in neurodegeneration.'], ["Alzheimer's disease (AD) is the most prevalent aging-associated neurodegenerative disease, with a higher incidence in women than men."], ['Thus, it can be reasoned that the APOE-epsilon4 allele would also impact neurodegeneration-associated structural brain changes.'], ['Gait behavior is considered an important indicator for the assessment of the general health status and provides a diagnostic observation for neuro-degenerative and musculo-skeletal diseases.'], ["EE improves cognitive function as well as ameliorates depressive and anxiety-like behaviors, making it a potentially effective neuroprotective strategy against neurodegenerative diseases such as Alzheimer's disease (AD).", 'The effectiveness of EE in enhancing brain activity against neurodegeneration is explored with a view to differences present in early and late life EE exposure, with its potential application in human being discussed.'], ['Hyperglycemia is one of the important causes of neurodegenerative disorders and aging.'], ['In vivo, alpha-syn PFF induced progressive neurodegeneration of dopaminergic neurons associated with motor deficits.'], ['Osteoarthritis (OA) is a joint degenerative disease that most affects old age.'], ['BACKGROUND: Grip strength is a widely used and well-validated measure of overall health that is increasingly understood to index risk for psychiatric illness and neurodegeneration in older adults.'], ["Alzheimer's disease (AD) is one of the serious and progressive neurodegenerative disorders in the elderly worldwide.", 'Flavonoids likewise hamper the movement of obsessive indications of neurodegenerative disorders by hindering neuronal apoptosis incited by neurotoxic substances.'], ['Uric acid has been shown to provide a neuroprotective effect in various neurodegenerative diseases through its antioxidant properties.'], ["Healthy aging is an ambitious aspiration for humans, but neurodegenerative disorders, such as Alzheimer's disease (AD), strongly affect quality of life."], ["Beyond cancer, moderate signal strength in embryonic neural cells may be associated with neurodevelopmental disorders, and moderate signals in aging may be associated with neurodegenerative diseases, like Alzheimer's disease."], ['In recent years, the regulation of ferroptosis to treat cancer, immune system disorders, and neurodegenerative diseases have seen an unprecedented surge of interest.'], ['Neurodegenerative disorders are typically characterized by inclusions of misfolded proteins and since lysosomes are an important site for cellular debris clearance, lysosomal dysfunction has been closely linked to neurodegeneration.', 'Consequently, many causal mutations or genetic risk variants implicated in neurodegenerative diseases encode proteins involved in endosomal-lysosomal function.', 'The recognition that TMEM106B can form amyloid fibrils and is present across neurodegenerative diseases sheds new light on TMEM106B as a central player in neurodegeneration and brain health, but also raises important new questions.'], ['Based on this finding, we propose a simple neurodegeneration model that is representative of normal physiological aging.'], ['These findings support the important role of microglia in neurodegeneration, and we speculate that pathology spreads throughout the brain along vulnerable connectivity pathways.'], ["Huntington's disease (HD) is a neurodegenerative disease associated with polyglutamine expansion in the protein Huntingtin."], ["Life expectancy in Western countries is increasing, with concomitant rise in ageing-related pathologies, including Parkinson's and Alzheimer's disease, as well as other neurodegenerative diseases."], ['Findings will provide new and critical insights into the role of undernutrition in neurocognitive ageing, how this role can differ by sex, genetic risk and timing of undernutrition exposure, and how modifications of dietary and physical activity behaviour can reduce the burden of undernutrition and neurodegeneration.'], ['During the aging process, due to aberrations of DNA methylation, biological processes are disrupted, leading to the emergence or progression of a variety of human diseases, including cancer, neurodegenerative disorders, cardiovascular disease and diabetes.'], ['To our knowledge, we provide the first evidence of LOY in the microglia, and highlight its potential roles in aging and the pathogenesis of neurodegenerative disorders such as AD.'], ["Microglia play important roles in maintenance of brain homeostasis, while due to some pathological stimuli in aging-related neurodegenerative diseases including Alzheimer's disease, they are malfunctioning."], ["Many aging-related degenerative diseases such as Alzheimer's disease, Parkinson's disease, and osteoarthritis have an inextricable connection with circadian rhythm.", 'Second, we systemically summarize the role of clock genes in aging and aging-related degenerative diseases.'], ["Alzheimer's disease (AD) is an irreversible, progressive neurodegenerative brain disorder and the most common form of dementia in the elderly with a long presymptomatic phase."], ['The formation of fibrils with neuronal Hb in various neurodegenerative diseases may indicate a common fibrillization pathway and a widespread target that could be applied in neurodegeneration therapy.'], ["BACKGROUND: Parkinson's disease (PD) is one of the most common neurodegenerative diseases in the aging population."], ['A proximity-to-CSF analysis showed that the group of thalamic nuclei situated immediately adjacent to CSF atrophied at a significantly greater atrophy rate (0.59% atrophy per year) than that of the group of nuclei located farther from CSF (0.36% atrophy per year), supporting a growing hypothesis that CSF-mediated factors contribute to neurodegeneration.'], ['Worldwide obesity has risen to record levels generating a major risk factor for metabolic syndrome, diabetes, hypertension, and cardiovascular disease as well as cancer and neurodegenerative diseases.'], ["Progressive iron accumulation in the substantia nigra in the aged human brain is a major risk factor for Parkinson's disease and other neurodegenerative diseases.", 'The current study details the neuronal response to excessive iron accumulation, which is associated with age-related neurodegenerative diseases.'], ['PRCIS: Primary open-angle glaucoma is a neurodegenerative disease highly prevalent in the European adult population, with cases expected to increase over the next 30 years.', 'CONCLUSION: POAG is a neurodegenerative disease that affects a large proportion of the older European population.'], ['We also describe emerging links between immunogenic MN and human diseases including cancer, neurodegenerative diseases and COVID-19.'], ['Lymphoblastoid cell lines (LCLs) have been proposed as an alternative to brain tissue for studying earlier phases of neurodegenerative diseases.', 'The use of LCLs might be appropriate for studying early immune system and inflammation, and some neural features in neurodegenerative dementias.'], ['However, a chronic and maladaptive neuroinflammatory response can exacerbate TBI and contribute to progressive neurodegeneration and long-term neurological impairments.'], ["Despite this, the link between CA and age-related neurodegenerative diseases, particularly Alzheimer's disease (AD), remains poorly defined."], ['The proposed pressure ulcer preventing system will be an efficient healthcare tool for families who had elderly bedridden patients, patients with chronic degenerative disease side effects, and terminal and postsurgical patients, as well as femur fractures, in their homes.'], ["Alzheimer's disease (AD) is the most common neurodegenerative disease in the elderly around the world as well as in China."], ['Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease associated with repetitive head trauma and is characterised by the perivascular accumulation of hyperphosphorylated tau (p-tau) in the depths of cortical sulci.', "Publications were included if they quantitively or qualitatively compared postmortem human tissue pathology in CTE to neuropathologically normal cases or other neurodegenerative diseases such as Alzheimer's disease (AD)."], ['Recent investigations indicated degenerative disease is taking an increasing part in SCI with the growth of the aging population.', 'However, little insight has been gained about the effect of cervical degenerative disease on the spinal cord during dynamic activities.', 'In this work, a dynamic fluid-structure interaction model was developed and validated to investigate the effect of anterior and posterior encroachment caused by degenerative disease on the spinal cord during normal extension and flexion.', 'This suggests that patients with cervical degenerative disease should avoid frequent or excessive flexion and extension which could result in motor function impairment, whereas moderate flexion is safe.'], ["Parkinson's disease (PD) is a common neurodegenerative disease in the elderly population."], ['Brain macrophage populations include parenchymal microglia, border-associated macrophages, and recruited monocyte-derived cells; together, they control brain development and homeostasis but are also implicated in aging pathogenesis and neurodegeneration.', 'Herein, we generate an ontogeny-resolved model of brain myeloid cell heterogeneity in development, homeostasis, and disease and identify cellular targets for the treatment of neurodegeneration.'], ['In addition, multiple changes can occur with ageing-related diseases such as neurodegeneration, atherosclerosis, deconditioning and polypharmacy.'], ["Alzheimer's disease (AD) is a progressive neurodegenerative disease that is ultimately fatal.", 'Interestingly, despite the prevalence of AD in human populations, the full AD phenotype has not been observed in any nonhuman primate (NHP) species, and it has been suggested that NHPs are immune to neurodegenerative diseases such as AD.'], ['Our findings highlight the importance of WM lesion burden in the elderly population, which should be considered in the development of prevention programs for neurodegeneration and cognitive impairment.'], ['BACKGROUND: The quality of the paraspinal muscles has been recommended as a surrogate marker for the evaluation of the severity of the lumbar degenerative diseases (LDD).'], ['INTRODUCTION: Non-amnestic presentations of neurodegenerative dementias, including posterior- and visual-predominant cognitive forms, are under-recognized.', 'As a short, self-report tool, the CPC-Q demonstrates potential to improve detection of non-amnestic neurodegenerative dementias in the clinical setting.'], ['Elevating neuroprotective proteins using adeno-associated virus (AAV)-mediated gene delivery shows great promise in combating devastating neurodegenerative diseases.'], ["BACKGROUND: Idiopathic Parkinson's disease is a slowly progressive neurodegenerative disease."], ['A deep and comprehensive exploration of the UPRmt can provide new directions and strategies for the treatment of human diseases, including aging, neurodegenerative diseases, cardiovascular diseases and diabetes.'], ["Alzheimer's disease (AD) is the most common neurodegenerative disorder in the elderly."], ['While associations between sTREM2 and tau in CSF are established, we sought to determine additional biological correlates of CSF sTREM2 during the prodromal stages of AD by evaluating CSF Abeta species (Abetax-40), a fluid biomarker of blood-brain barrier integrity (CSF/plasma albumin ratio), and CSF biomarkers of neurodegeneration measured in 155 participants from the Vanderbilt Memory and Aging Project.', 'Abetax-40 levels, as well as the CSF/plasma albumin ratio, explained additional and unique variance in sTREM2 levels above and beyond that of CSF biomarkers of neurodegeneration.'], ['Presence (+) or absence (-) of neurodegeneration (N) was assessed using temporal cortical thickness.'], ["Alzheimer's disease (AD) is a neurodegenerative disorder, and no effective treatments are available to treat this disorder."], ['Currently, many non-communicable diseases are threatening global human health, noticeably: diabetes, neurodegenerative diseases, cancer, and other ailment related to chronic inflammation and ageing.'], ['Alterations in the cell autophagic machinery have been implicated in several disease conditions, including neurodegeneration, autoimmunity, cancer, infection, inflammatory diseases, and aging.'], ['The framework of microglia-turned-destroyers may instigate new approaches to counter microglia-driven neurodegeneration in MS.'], ["Alzheimer's disease (AD) is a neurodegenerative disease that seriously affects the life and health of the elderly."], ['Indeed, oxidative stress yields abnormal cysteine oxidations that affect protein function and structure and can lead to neurodegenerative diseases.', 'In a context of population ageing, validation of novel biomarkers for detection of neurodegenerative diseases is important.'], ['Several studies have described changes in the gut microbiome across age groups up to the extreme limits of lifespan, including maladaptations that occur in the context of age-related conditions, such as frailty, neurodegenerative diseases, and cardiometabolic diseases.'], ['Phenotypic variations in the retinal pigment epithelial (RPE) layer are often a predecessor and driver of ocular degenerative diseases, such as age-related macular degeneration (AMD), the leading cause of vision loss in the elderly.'], ["Neuropathological investigations were performed on 10 cases, confirming: Alzheimer's disease only (2 cases), mixed Alzheimer's disease with Lewy bodies (2 cases), mixed Alzheimer's disease with amyloid angiopathy (1 case), moderate non-amyloid small vessel angiopathy (1 case), a non-specific neurodegenerative disorder (1 case), Parkinson's disease with Lewy body dementia (1 case), and Lewy body dementia (2 cases)."], ['In conclusion, continuous, non-full-scale activation of the HIF pathway appears to mediate protection against neurodegeneration via several mechanisms and should be studied as a treatment option for AD.'], ['Adenosine deaminases acting on RNA (ADARs) are RNA-editing enzymes that are also implicated as important regulators of human ageing, and ADAR inactivation causes age-associated pathologies such as neurodegeneration in model organisms3,4.'], ['Understanding normal brain aging physiology is essential to improving healthy human longevity, differentiation, and early detection of diseases, such as neurodegenerative diseases, which are an enormous social and economic burden.'], ["Alzheimer's disease (AD) is a progressive neurodegenerative disorder with growing major health impacts, particularly in countries with aging populations."], ['Subclinical but high glycemia levels in healthy individuals and MPV in AD patients are associated with neurodegeneration in AD-sensitive brain regions but not with amyloid deposition.'], ['Abeta deposition in the medial parietal cortex appears to be the initial stage of AD, but it does not have a strong correlation with neurodegeneration.'], ['Subsequently, we quantified and analyzed vascular alterations in 45AIS and 50 AD patients, two prominent cerebrovascular and neurodegenerative disorders.'], ['Participants described an additional challenge of physicians attributing cognitive decline to normal aging, rather than signs of a neurodegenerative disorder.'], ['We focused on the impact of WML on two neurodegenerative diseases with different pathology.', 'The WML location together with underlying disease related neurodegeneration may play a role in determining the effect of WML on cognition.'], ['One-quarter (26%) of the patients experienced complications: radial head subluxation (1), skin sore (1), degenerative arthropathy (1), pain on movement (2), click in movement of the elbow (5), and local pain (8).'], ['The incidence and prevalence of sleep disorders continue to increase in the elderly populace, particularly those suffering from neurodegenerative and neuropsychiatric disorders.', 'This review focuses on the mechanism and effects of sleep dysfunction in neurodegenerative and neuropsychiatric disorders.', 'Moreover, we explain the perturbation in brainwaves during disturbed sleep and the ocular perspective of neurodegenerative and neuropsychiatric manifestations in sleep disorders.'], ['Lastly, we examine the potential role of GnRH in aging and inflammation and its therapeutic potential for neurodegenerative disease and spinal cord lesions.'], ['Using post-mortem brain samples from eight HIV patients and eight non-neurological disease controls, we identify a subset of CNS phagocytes highly enriched in LGALS3, CTSB, GPNMB and HLA-DR, a signature identified in the context of ageing and neurodegeneration.'], ["Adherence to Mediterranean-DASH Diet Intervention for Neurodegenerative Delay (MIND) may lower the risk of dementia by impacting immunity and cholesterol, which are pathways also implicated by genome-wide association studies of Alzheimer's Dementia (AD)."], ['Ageing and chronic degenerative pathologies demonstrate the shared characteristics of high bioavailability of reactive oxygen species (ROS) and oxidative stress, chronic/persistent inflammation, glycation, and mitochondrial abnormalities.', 'Reinforcing the antioxidant defence system and/or counteracting the deleterious repercussions of immoderate reactive oxygen and nitrogen species (RONS) is critical and may curb the progression of ageing and chronic degenerative syndromes.', "In this review, we summarise the interconnected mechanism of oxidative stress and chronic inflammation that contributes to ageing and chronic degenerative pathologies, including neurodegenerative diseases, such as Alzheimer's disease (AD) and Parkinson's disease (PD), cardiovascular diseases CVD, diabetes mellitus (DM), and chronic kidney disease (CKD).", 'We also highlight potential counteractive measures to combat ageing and chronic degenerative diseases.'], ["As a neurodegenerative disease, Alzheimer's disease (AD) seriously affects the health of older people."], ["Canine cognitive dysfunction (CCD) is a highly prevalent neurodegenerative disease considered the canine analog of early Alzheimer's disease (AD)."], ["Alzheimer's disease (AD) is a progressive neurodegenerative disorder and previous studies have showed its association with accelerated aging."], ["Accumulating evidence demonstrates that impaired mitophagy has been associated with many neurodegenerative diseases, such as Alzheimer's disease (AD), Parkinson's disease (PD) and Huntington's disease (HD), amyotrophic lateral sclerosis (ALS) in a variety of patients and disease models with neural death, oxidative stress and disturbed metabolism, either as the cause or consequence.", 'These findings suggest that modulation of mitophagy may be considered as a valid therapeutic strategy in neurodegenerative diseases.', 'In this review, we summarize recent findings on the mechanisms of mitophagy and its role in neurodegenerative diseases, with a particular focus on mitochondrial proteins acting as receptors that mediate mitophagy in these diseases.'], ['7,843 adults with newly diagnosed dementia without a previous history of dementia or neurodegenerative disease between 2006 and 2013 were identified and included in our study.'], ['Serum neurofilament light chain is a putative biomarker of neurodegeneration in multiple sclerosis, aging, and other neurodegenerative diseases.'], ['In conclusion, the fresh extract has neuroprotective activity that could have a promising role in ameliorating age-related neurodegeneration.'], ['INTRODUCTION: Primary familial brain calcification (PFBC) is a rare neurodegenerative disorder that presents cognitive and movement impairment.'], ['We here assessed the impact of aging and inflammation on dopaminergic neurodegeneration in the hm2alpha-SYN-39 mouse model of PD that carries the human, A30P/A53T double-mutated alpha-synuclein gene.', 'The findings in the hm2alpha-SYN-39 mouse model strengthen the evidence that T cell and glial cell responses are involved in the age-related neurodegeneration in PD.', 'The slow and age-dependent progression of neurodegeneration and neuroinflammation in the hm2alpha-SYN-39 PD rodent model underlines its translational value and makes it suitable for studying anti-inflammatory therapies.'], ['Nicotinamide riboside (NR), a dietary NAD precursor, has been suggested to ameliorate the aging process or neurodegeneration.'], ['Ageing is a complex biological phenomenon representing the major risk factor for developing age-related diseases, such as cardiovascular pathologies, neurodegenerative diseases, and cancer.'], ['Such examples include identifying methylation sites and the genes most strongly predictive of aging-a subset of which have shown strong potential as biomarkers of neurodegenerative disease and cancer; relating epigenetic clock predictions to hallmarks of aging; and using longitudinal studies of DNA methylation to characterize human disease, resulting in the discovery of epigenetic indications of type 1 diabetes and the propensity for psychotic experiences.'], ['Senescent cells are characterized by a durable cell proliferation arrest and the acquisition of a proinflammatory senescence-associated secretory phenotype (SASP), which participates in the progression of neurodegenerative disorders.'], ['All cases were from the Mayo Clinic brain bank for neurodegenerative disorders and most were followed longitudinally in the ALS Clinic.'], ['An older adult with DS or LLD should be monitored for possible cognitive decline or neurodegenerative disorders.'], ['Periodontitis, a chronic, inflammatory disease, induces systemic inflammation and contributes to the development of neurodegenerative diseases.', "The precise etiology of the most common neurodegenerative disorders, such as sporadic Alzheimer's, Parkinson's diseases and multiple sclerosis (AD, PD, and MS, respectively), remains to be revealed.", 'Systemic inflammation can lead to deleterious consequences on the brain if the inflammation is sufficiently severe or if the brain shows vulnerabilities due to genetic predisposition, aging, or neurodegenerative diseases.', 'Currently, the lack of understanding of the pathogenesis of neurodegeneration is hindering treatment development.'], ['We then propose pathways of injury common to various forms of sleep disruption and consider the implications of this injury in aging and in neurodegenerative disorders.'], ['Some studies have found that resistance exercise using an elastic band can prevent chronic health problems such as osteoporosis, degenerative diseases, and frozen shoulders.'], ['We characterized the additive contribution of cerebrovascular biomarkers to amyloid and neurodegeneration biomarkers (AV(N)) when modeling prospective, longitudinal cognitive trajectories within 3 major racial/ethnic groups.', 'Participants (n = 172; age = 69-96 years; 62% women; 31%/49%/20% Non-Hispanic White/Non-Hispanic Black/Hispanic) from the Washington Heights-Inwood Columbia Aging Project were assessed for amyloid (Florbetaben PET), neurodegeneration (cortical thickness, hippocampal volume), and cerebrovascular disease (white matter hyperintensity (WMH), infarcts).'], ['This is a new, unexpected and interesting result, as most studies of the KP in neurodegenerative disease show reduced 3-HAA/AA ratio after diagnosis.'], ['The findings suggest that HIV might interact with age-related neurodegeneration to contribute to cognitive decline in PWH.'], ["Alzheimer's disease (AD) is a chronic neurodegenerative disease characterized by progressive dementia, and amnestic mild cognitive impairment (aMCI) has been defined as a transitional stage between normal aging and AD."], ["Parkinson's disease (PD) is the second most common neurodegenerative disorder, and aging and genetic and environmental exposure can contribute to its pathogenesis.", 'DNA methylation has been suggested to play a pivotal role in neurodevelopment and neurodegenerative diseases.'], ['Elucidation of MG pathogenesis may provide more insight into the pathophysiology of neurodegenerative diseases.'], ['Reduced cerebrovascular response to neuronal activation is observed in patients with neurodegenerative disease.', 'In the present study, we examined the correlation between reduced cerebrovascular response to visual activation (DeltaCBFVis.Act) and subclinical cognitive deficits in a human population of mid-sixties individuals without neurodegenerative disease.', 'Such a correlation would suggest that impaired cerebrovascular function occurs before overt neurodegenerative disease.', 'Cerebrovascular dysfunction could be an early sign of a trajectory pointing towards the development of neurodegenerative disease.'], ["Alzheimer's disease (AD) is the most prominent neurodegenerative disease represented by the loss of memory and cognitive impairment symptoms and is one of the major health imperilments among the elderly.", 'Methamphetamine (METH) is a psychostimulant drug that causes neurodegeneration and detrimental cognitive deficits.', 'Melatonin, an indolamine produced and released by the pineal gland as well as other extrapineal, has been protective against METH-induced neurodegenerative processes, thus rescuing neuronal cell death.'], ['Mitochondria are the major source of reactive oxygen species (ROS), whose aberrant production by dysfunctional mitochondria leads to oxidative stress, thus contributing to aging as well as neurodegenerative disorders and cancer.'], ['BACKGROUND: Gait pattern coordination is affected by several factors (e.g., neurodegeneration), while aging is known to have a significant negative impact.'], ['Such comparisons can further our understanding of which aspects of human aging are evolutionarily conserved or specific to our species, especially given that humans are distinguished by a long lifespan, large brain, and, potentially, more severe neurodegeneration with age.'], ['Standardized cognitive empathy tests could also provide novel approaches in the early detection of developmental vulnerabilities in a range of neurological conditions, and within neuropsychiatric and neurodegenerative disorders in which cognitive empathy is known to be impaired.'], ['OBJECTIVES: Cervical myelopathy (CM) and lumbar canal stenosis (LCS) are common degenerative spinal diseases among the elderly, and the major associated complaints include lower urinary tract symptoms (LUTS).', 'These results would encourage urologists to consider an orthopedic consultation when lower urinary tract dysfunction is identified in patients with degenerative spinal diseases.'], ["Alzheimer's disease (AD) is a slowly progressive brain degenerative disorder which gradually impairs memory, thinking, and ability to perform easy routine tasks.", 'This degenerative disorder mainly targets the elderly people and has imposed an endemic burden on society.'], ['The elderly is liable to suffer from disorders such as neurodegenerative diseases, cancer, and diabetes.'], ['This review outlines general issues facing biomaterial integration and emphasizes the importance of tissue-derived macromolecular components in regulating essential homeostatic, immunological, and pathological processes to increase biomaterial integration for patients suffering from joint degenerative diseases.'], ['Alteration in brain glucose metabolism due to glucose uptake reduction has been described in the onset of certain neurodegenerative disorders.', 'PRACTICAL APPLICATIONS: Available scientific evidence describes oxidative stress as one of the physiological processes contributing to aging-associated neurodegeneration in humans.'], ['Previous studies have shown that mutated forms or reduction of UCH-L1 are related to neurodegenerative disorders, but the mechanisms of pathogenesis are still not well understood.'], ['The lack of effective drugs against these neurodegenerative disorders makes it imperative to identify new strategies for their prevention and treatment.', 'Recent studies have revealed that harnessing the power of the gut microbiota through modification of diet may be a valuable approach for reducing the risk, modulating the symptoms, and ameliorating the pathophysiological aspects of neurodegenerative diseases.', 'This article focuses on several dietary components, which have been demonstrated to affect the gut microbiota-brain axis and therefore could lead to attenuation of specific pathological processes in neurodegenerative diseases.'], ['In addition, we discussed the potential of applying nano-drug delivery to neurodegenerative diseases, such as AD, to overcome the challenge of crossing the blood brain barrier and specifically target molecules/pathways of interest with minimal side effects.'], ['Brain-state-dependent stimulation during slow-wave sleep is a promising tool for the treatment of psychiatric and neurodegenerative diseases.'], ['Neurodegenerative diseases represent a growing healthcare problem, mainly related to an aging population worldwide and thus their increasing prevalence.', "In particular, Alzheimer's disease (AD) and Parkinson's disease (PD) are leading neurodegenerative diseases."], ['Parkinson disease (PD) is a progressive neurodegenerative disease that affects peripheral organs as well as the central nervous system and involves a fundamental role of neuroinflammation in its pathophysiology.'], ['Neurodegenerative diseases are a major health burden.', 'The aim of this study was to evaluate neurodegeneration-associated protein deposition and autophagy as well as microglial activation within and surrounding glioblastoma.', 'Deposition of neurodegeneration-associated proteins was found in the majority of cases (86.4%) but in distant sites.', 'The variety and distribution of distant neurodegeneration-associated protein aggregates observed in the majority of cases, suggest a preexisting rather than a tumor-induced neurodegenerative condition.'], ['We previously reported discovery of Abeta deposition, beta-amyloidopathy, and co-localizing supranuclear cataracts (SNC) in lenses from people with AD, but not other neurodegenerative disorders or normal aging.', 'These results represent the first evidence of AD-related Abeta pathology outside the brain and point to lens Abeta as an optically-accessible AD biomarker for early detection and longitudinal monitoring of this devastating neurodegenerative disease.'], ["BACKGROUND: Amyloid deposition is a primary predictor of Alzheimer's disease (AD) and related neurodegenerative disorders."], ["Currently, with the aging of the world's population and increase of life expectancy, cognitive dysfunction has gradually become a disease of high incidence, which is accompanied by neurodegenerative diseases in elderly individuals."], ['AD is a multifactorial disease that involves neurodegeneration in the brain with mild dementia and deficits in memory and other cognitive domains.'], ['Ferroptosis is linked to numerous disorders, including cardiovascular disease, neurodegeneration, and cancer.', 'In turn, ferroptosis has been linked to the development of various health disorders, including neurodegeneration, cardiovascular disease, and cancer.'], ["Some of these proteins are known to cause a number of degenerative diseases in humans, such as amyloid-beta (Abeta) in Alzheimer's disease (AD), alpha-synuclein in Parkinson's disease (PD), and insulin and its analogues in insulin-derived amyloidosis."], ["Alzheimer's disease (AD) is the most common neurodegenerative disease in the world.", 'Likewise, it analyzes the multiple mutations identified to date through GWAS that are associated with a high or low risk of developing this neurodegeneration.'], ["Alzheimer's disease (AD) is a progressive neurodegenerative disorder that accounts for more than half of all dementia cases in the elderly."], ['Rheumatic diseases cover a wide spectrum of conditions, including primary and secondary degenerative joint diseases and autoimmune inflammatory rheumatic diseases.'], ['Neurotrophic factors are key factors associated with the progression of degenerative neuropathies and gliomas.'], ['While many of the maladies of the 20th century are steadily coming under control, the march of neurodegenerative disorders continues largely unchecked.', 'They represent a group of chronic, progressive and, ultimately, fatal neurodegenerative diseases.'], ['Increased content of senescent cells in the brain, such as glial cells, has been reported to impact cognition both in animal models and human tissue during normal aging and in the context of neurodegenerative disease.'], ['The small size, genetic proximity to humans and prolonged senescence, make this lemur an emerging model for neurodegenerative diseases.'], ['Osteoarthritis (OA) is a common chronic degenerative joint disease associated with a variety of risk factors including aging, genetics, obesity, and mechanical disturbance.'], ['Parkinson disease (PD) is the second most common neurodegenerative disease in the world.'], ['Clinical trials of putative disease-modifying therapies in neurodegeneration have obeyed the century-old principle of convergence, or lumping, whereby any feature of a clinicopathologic disease entity is considered relevant to most of those affected.', 'As individuals affected by the same neurodegenerative disorder do not share the same biological drivers, splitting such disease into small molecular/biological subtypes, to match people to therapies most likely to benefit them, is vital in the pursuit of disease modification.', 'The reconfiguration of disease-modifying efforts for patients with neurodegenerative disorders will require a paradigm shift from lumping to splitting and from proteinopathy to proteinopenia.'], ['BACKGROUND: Neurodegenerative diseases (NDDs) are characterized by progressive neuronal dysfunctionality which results in disability and human life-threatening events.', 'Considering the complex pathophysiological mechanisms behind NDDs, Janus kinase (JAK), insulin receptor substrate (IRS), phosphoinositide 3-kinase (PI3K), and signal transducer and activator of transcription (STAT) seem to play critical roles during neurodegeneration/neuroregeneration.'], ['There is considerable interest in applying this approach to treatments designed to slow or halt the progression of neurodegenerative diseases.', 'In contrast to the enormous progress in oncology, precision medicine in the field of neurodegeneration faces multiple challenges.', 'A critical barrier to advances in this field is the question of whether the common sporadic neurodegenerative diseases (of the elderly) are single uniform disorders (particularly related to their pathogenesis) or whether they represent a collection of related but still very distinct disease states.', 'In this chapter, we briefly touch on lessons from other fields of medicine that might be applied to the development of precision medicine for DMT in neurodegenerative diseases.', 'We conclude with comments on how we can move from this complex disease heterogeneity to the successful application of precision medicine principles in DMT for neurodegenerative diseases.'], ["Obesity is a risk factor for neurodegenerative disease associated with cognitive dysfunction, including Alzheimer's disease.", 'These findings suggest that increased QA is associated with cognitive decline in obesity and that butyrate alleviates neurodegeneration.'], ['Among them, vitamin E has been widely studied in AD, given the plausibility of its various biological functions in influencing neurodegeneration.'], ['Aging and neurodegenerative diseases share common hallmarks, including mitochondrial dysfunction and protein aggregation.', 'Moreover, one of the major issues of the demographic crisis today is related to the progressive rise in costs for care and maintenance of the standard living condition of aged patients with neurodegenerative diseases.', 'There is a divergence in the etiology of neurodegenerative diseases.', 'Still, a disturbed endogenous pro-oxidants/antioxidants balance is considered the crucial detrimental factor that makes the brain vulnerable to aging and progressive neurodegeneration.', "The present review focuses on the complex relationships between oxidative stress, autophagy, and the two of the most frequent neurodegenerative diseases associated with aging, Alzheimer's disease (AD) and Parkinson's disease (PD).", 'Elucidation of the underlying mechanisms involved in deleterious conditions predisposing to neurodegeneration in aging, including the diminished role of melatonin, is important for elaborating precise treatment strategies for the pathogenesis of AD and PD.'], ['Better elucidating optic nerve neurodegeneration remains of interest, specifically investigating human ECM, RGCs, axons, oligodendrocytes, and astrocytes; clarifying the exact processes of aged ocular connective tissue alterations and their ultrastructural impacts; and developing novel technologies and pharmacotherapies that target known genetic, biochemical, matrisome, and neuroinflammatory markers.'], ["As people age, their risks of developing degenerative diseases such as cancer, diabetes, Parkinson's Disease (PD), Alzheimer's Disease (AD), rheumatoid arthritis, and osteoporosis are generally increasing.", 'In most countries, neurodegenerative diseases are generally recognized as the number one cause afflicting the elderly.', 'Although there are many papers on the prevention or suppression of diseases by melatonin, there are very few papers about the effects of melatonin on ER stress in neurons and neurodegenerative diseases.', 'This paper aims to summarize and present the effects of melatonin reported so far, focusing on its effects on neurons and neurodegenerative diseases related to ER stress.', 'Therefore, melatonin is crucial in protecting neurons and treating neurodegeneration against ER stress.'], ['Further preclinical studies for the development of 5-HT7 modulation against neurodevelopmental disorders and neurodegenerative diseases have been ongoing.'], ['In addition, the acute morbidity caused by TBI is implicated in the development of devastating neuropsychiatric and neurodegenerative sequela.', "TBI is associated with the development of a neurodegenerative condition termed 'Punch Drunk syndrome' or 'dementia pugilistica', and the more recently renamed 'chronic traumatic encephalopathy'.", 'Chronic traumatic encephalopathy (CTE) is a slowly progressive neurodegenerative condition caused by a single or repetitive blow to the head.'], ['Research into the functions of nicotinamide adenine dinucleotide (NAD) has intensified in recent years due to the insight that abnormally low levels of NAD are involved in many human pathologies including metabolic disorders, neurodegeneration, reproductive dysfunction, cancer, and aging.'], ["Aging has been recognized as one of the main risk factors for the world's most prevalent diseases such as neurodegenerative disorders, cancer, cardiovascular disease, and metabolic diseases."], ['AD is the most common neurodegenerative disease associated with human aging.'], ['Therefore, it is critical to study age-dependent trajectories of biomarkers in DGM nuclei for understanding brain development and aging, as well as predicting cognitive or neurodegenerative diseases.'], ['While bc1-generated superoxide plays a beneficial signaling role, excess production of superoxide lead to aging and degenerative diseases.'], ['BACKGROUND: Age-related changes in the cerebrovasculature, including blood-brain barrier (BBB) disruption and vascular dementia, are emerging as potential risks for many neurodegenerative diseases.'], ['Unfortunately, data on the efficacy of pharmacologic treatment of depressive symptoms in patients with the neurodegenerative disease remain inconclusive.'], ["Recently, increasing studies are indicating a close association between dysregulated enhancers and neurodegenerative diseases, such as Alzheimer's disease (AD)."], ['The incidence and prevalence of age-related neurodegenerative dementias have been increasing.', 'The keywords used were related to neurodegenerative dementias, ageing and medicinal plants.', 'As a result, there is current clinical and preclinical scientific information on 49 species used in traditional medicine for ageing-related problems, including neurodegenerative dementias.', 'In conclusion, the potential therapeutic effect of the different medicinal plants depends on the type of neurodegenerative dementia and its stage of development, but more clinical and preclinical research is needed to find better, safer and more effective treatments.'], ['Gangliosides (GAs) and sulfatides (STs) are acidic glycosphingolipids that are particularly abundant in the nervous system and are closely related to aging and neurodegenerative disorders.'], ["Parkinson's disease is a health-threatening neurodegenerative disease of the elderly with clinical manifestations of motor and non-motor deficits such as tremor palsy and loss of smell."], ['While Patronin mutants did not affect early mortality, Lis-1 compound heterozygotes (Lis-1x/Lis-1y) had increased early mortality following injury at 20-27 or 0-7 days old compared with Lis-1 heterozygotes (Lis-1x/+), and flies that survived 24 hours after injury had increased neurodegeneration but an unaltered lifespan, indicating that Lis-1 affects TBI outcomes independently of effects on aging.', 'These data suggest that Lis-1 activity is required in the brain to ameliorate TBI outcomes through effects on axonal transport, microtubule stability, and other microtubule proteins such as tau, implicated in chronic traumatic encephalopathy, a TBI-associated neurodegenerative disease in humans.'], ['Neuroinflammation is the hallmark feature of many neurodegenerative disorders, including HIV-1-associated neurocognitive disorders (HAND).'], ['Disrupted biological function, manifesting through the hallmarks of aging, poses one of the largest threats to healthspan and risk of disease development, such as metabolic disorders, cardiovascular ailments, and neurodegeneration.'], ['Background and Objectives: Osteoarthritis (OA) of the knee is a degenerative disorder characterized by damage to the joint cartilage, pain, swelling, and walking disability.'], ["Alzheimer's disease (AD) is a leading neurodegenerative disease with deteriorating cognition as its main clinical sign.", 'The focus of this narrative review is to explore the modes of neurodegeneration taking place in the locus coeruleus during the natural aging process of the trigeminal nerve connections from the teeth and microbial dysbiosis, and to postulate a pathogenetic mechanism due to periodontal damage and/or infection focused on Treponema denticola.'], ["Tauopathies are a heterogeneous group of neurodegenerative disorders that are clinically and pathologically distinct from Alzheimer's disease (AD) having tau inclusions in neurons and/or glia as their most prominent neuropathological feature."], ['When Ass binds to either CD36 or TLR4, it sets off a chain reaction of inflammatory chemokines and cytokines that ultimately results in neurodegeneration.'], ['The SIRT6 deacetylase has been implicated in DNA repair, telomere maintenance, glucose and lipid metabolism and, importantly, it has critical roles in the brain ranging from its development to neurodegeneration.', 'Overall, our results suggest that the reduced levels of SIRT6 in the aging brain and neurodegeneration initiate mitochondrial dysfunction by altering gene expression, ROS production, and mitochondrial decay.'], ["Mitochondrial dysfunction is largely involved in aging; age-related diseases such as cancer, diabetes, and obesity; and neurodegenerative disorders including Alzheimer's disease, Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis, multiple sclerosis, and others."], ['These results encourage further investigations in cognitive impairments and neurodegeneration.'], ['We found that RAE is associated with rapidly evolving regions in the human genome, adaptive signaling processes, and genes linked to age-related diseases such as neurodegeneration and cancer.'], ["Episodic memory deficits are a common consequence of aging and are associated with a number of neurodegenerative disorders (e.g., Alzheimer's disease)."], ['BACKGROUND: In the older general population, neurodegenerative diseases (NDs) are associated with increased disability, decreased physical and cognitive function.'], ['Being hCA VII involved in brain function and metabolism, the newly identified CA activators might be promising hit compounds with potential therapeutic applications in ageing, epilepsy or neurodegeneration.'], ['Ng levels were quantified in three brain regions associated with cognitive change found during ageing and neurodegenerative diseases, namely the middle temporal gyrus, primary visual cortex and the posterior hippocampus using immunohistochemistry.'], ['Twenty-four studies were selected after PubMed, Scopus and Google Scholar searches for the evaluation of moderate alcohol/wine consumption and health effects: eight studies concerned cardiovascular diseases, three concerned type 2 diabetes, four concerned neurodegenerative diseases, five concerned cancer and four were related to longevity.', 'The analysis clearly indicates that wine differs from other alcoholic beverages and its moderate consumption not only does not increase the risk of chronic degenerative diseases but is also associated with health benefits particularly when included in a Mediterranean diet model.'], ['Defects and dysregulation of mitochondrial functions are critically involved in pathological mechanisms contributing to aging, cancer, inflammation, neurodegenerative diseases, and other severe human diseases.'], ["I hope that this perspective, though perhaps too simplified, will bring us closer to the essence of aging-related neurodegenerative disorders and will soon allow us to develop new preventive/therapeutic strategies in our struggle with dementia, Alzheimer's disease, and Parkinson's disease."], ['This review focuses on the roles of SOX transcription factors in stem cell exhaustion and age-related diseases, including neurodegenerative diseases, visual deterioration, chronic obstructive pulmonary disease, osteoporosis, and age-related cancers.'], ['However, the exact mechanism underlying ApoE4 impact on AD progression is unclear, while no effective therapies are available for this highly debilitating neurodegenerative disorder.'], ['Furthermore, these findings provide targets for further pharmacological approaches of mitochondrial diseases and validate iNs as a reliable platform for studies in neuronal aspects of aging, neurodegenerative disorders, and mitochondrial diseases.'], ['However, it remains unclear how biomechanical behavior of the lumbar spine is affected by osteoporosis under whole-body vibration, which is considered a significant risk factor for degenerative spinal disease and is typically present when driving a car.'], ["These studies raise the intriguing possibility that the newly discovered pathways, including the glymphatic system, lymphatic meningeal vessels and skull-brain communication channels, are impaired in aging and neurovascular and neurodegenerative diseases associated with dementia, including Alzheimer's disease (AD) and AD-related dementia."], ['If successful, stem cell therapies offer the potential to treat, for example degenerative diseases.'], ["Secondly, we describe how several age-related neurodegenerative diseases, such as amyotrophic lateral sclerosis and Huntington's disease, are related with defects in nucleocytoplasmic transport."], ['Abnormal proteins also accumulate as a result of age-related neurodegenerative diseases.'], ['Accumulation of somatic mutations in human neurons is associated with aging and neurodegeneration.'], ['Here, we performed a detailed analysis of DKK2 in mouse models of neurodegeneration, and in human AD brain.', "In summary, the difference in microglial expression of the DAM/ARM gene DKK2 between mouse models and human AD brain highlights the increasingly recognized limitations of using mouse models to recapitulate facets of human neurodegenerative disease.Significance StatementThe endogenous negative Wnt regulator Dkk2 is significantly upregulated at the mRNA level in microglia of Alzheimer's disease (AD) mouse models, implying that microglia derived Dkk2 protein may detrimentally contribute to a reduced Wnt signaling tone in the AD brain, a known pathophysiological manifestation.", 'The success of neurodegeneration animal models has relied on pathophysiology that for the most part correctly modelled human disease.', 'Increasingly, however, limitations to the validity of mouse models to recapitulate human neurodegenerative disease have become apparent, as evidenced by the present study by the difference in microglial DKK2 expression between AD mouse models and human AD brain.'], ["OBJECTIVES: Parkinson's disease (PD) is a complex neurodegenerative disorder, affecting 2-3% of the elderly population."], ['Conclusion-The result from the present study depicts that chronic inflammation and lower Vitamin D level influences neurodegeneration and decline in cognitive performance in the elderly population.'], ['The authors hypothesize that the development of tardive parkinsonism might be due to a neurotoxic effect of the pharmacodynamic proprieties of the calcium channel blockers and their metabolites, exerted on post-synaptic striatal neurons and/or a neurotoxic damage on presynaptic DA neurons in patients without an underlying subclinical degenerative parkinsonism, so accounting for the stable and non-progressive course over time.'], ['Specific subfields within the hippocampus have shown vulnerability to chronic stress, highlighting the importance of looking regionally within the hippocampus to understand the role of psychosocial factors in the development of neurodegenerative diseases.'], ['Hyperplastic and degenerative lesions were common morbidities found in this elderly dog population.'], ['The CSF clusterin level decreased at the early stage are related to abnormal Abeta pathology; and the increased levels are associated with tau pathology and neurodegeneration.'], ["Furthermore, we summarize recent evidence suggesting that CD may also be a predisposing factor for the development of age-related neurodegenerative diseases (NDDs) such as Alzheimer's disease (AD), Parkinson's disease (PD), and Huntington's disease (HD), although more investigation is required to prove this link."], ['Aging is a major risk factor for common neurodegenerative diseases.'], ['Our results showed age-related differences in NAA, Cho, and mIns across brain regions, suggesting the presence of neurodegeneration and altered gliosis.'], ['In addition to osteoporosis, vitamin D deficiency has been associated with cardiovascular disease, diabetes, cancer, infections and neurodegenerative disease.'], ['Serum GDF15 levels are correlated with multiple neurodegenerative diseases.'], ["In this study, we investigated the capability of plasma core AD biomarkers in predicting cerebral Abeta deposition burden among the China Aging and Neurodegenerative Disorder Initiative (CANDI) cohort consisting of cognitively normal (CN), mild cognitive impairment (MCI), AD dementia, and non-Alzheimer's dementia disease (Non-ADD)."], ['BACKGROUND AND OBJECTIVES: The specificity of novel blood biomarkers for multiple sclerosis (MS)-related neurodegeneration is unclear because neurodegeneration also occurs during normal aging.', 'To understand which aspects of neurodegeneration the serum biomarkers neurofilament light (sNfL), serum glial fibrillary acidic protein (sGFAP), and serum contactin-1 (sCNTN1) reflect, we here explore their cross-sectional association with disability outcome measures and MRI volumes in a unique cohort of people with MS (PwMS) of the same age.', 'This demonstrates the potential of sNfL and sGFAP as complementary biomarkers of neurodegeneration, reflected by disability, in progressive MS.'], ['Aging causes functional decline and degeneration of neurons and is a major risk factor of neurodegenerative diseases.'], ['BACKGROUND: The Early Detection of Neurodegeneration (EDoN) is a global initiative that aims to explore the potential of wearable technologies and smartphone applications to detect preclinical dementia, with aspirations to validate a digital toolkit for clinical practice.'], ['Hippocampal blood-brain barrier (BBB) permeability may increase in normal healthy ageing and contribute to neurodegenerative disease.'], ['Genetic variation in TMEM106B is known to influence the risk and presentation of several neurodegenerative diseases, especially frontotemporal dementia (FTD) caused by mutations in the progranulin gene (GRN).'], ['Moreover, dysregulated innate and adaptive immune responses in patients with chronic inflammatory conditions, such as inflammatory bowel disease, allergies, and neurodegenerative disorders, are now recognised to occur in parallel with activation of coagulation.'], ['It presents with declines in tissue and cell functions and significant increases in the risks of various aging-related diseases, including neurodegenerative diseases, cardiovascular diseases, metabolic diseases, musculoskeletal diseases, and immune system diseases.'], ['FUNDING: The National Institute on Aging, Riney and Brennan Funds, the Eunice Kennedy Shriver National Institute of Child Health and Human Development, the German Center for Neurodegenerative Diseases, and the Japan Agency for Medical Research and Development.'], ['Translational Relevance: This study contributes to our understanding of retinal neurodegeneration in normal aging and in patients with chronic kidney diseases.'], ['Dietary intake of NAD+ precursors, such as nicotinamide riboside (NR), is a safe and effective avenue for augmenting NAD+ levels in peripheral tissues in humans, yet evidence supporting their ability to raise NAD+ levels in the brain or engage neurodegenerative disease pathways is lacking.'], ['Conclusions and Relevance: Results of this cross-sectional study of 2 observational cohorts suggest that the p-tau abnormality as an early event in AD pathogenesis was associated with amyloid-beta accumulation and highlights the need for careful interpretation of p-tau biomarkers in the context of the amyloid/tau/neurodegeneration, or A/T/(N), framework.'], ['The activities of different histone deacetylases (HDACs) regulate microglial function during development and neurodegeneration.'], ["BACKGROUND: Alzheimer's disease (AD) is the most common form of neurodegenerative dementia among the elderly."], ['Small molecules that bind to Hub1 would be of interest to study the protein-protein interaction of Hub1/Snu66, which is linked to several human pathologies, such as hypercholesterolemia, premature aging, neurodegenerative diseases, and cancer.'], ["Alzheimer's disease (AD) is a common neurodegenerative disorder with progressive cognitive impairment in the elderly."], ['Impaired proteostasis is associated with normal aging and is accelerated in neurodegeneration.', 'In a subset of frontotemporal lobar degeneration with tau pathology (FTLD-tau) cases, pathogenic mutations in the microtubule-associated protein tau (MAPT) gene are sufficient to cause tau accumulation and neurodegeneration.'], ["Alzheimer's disease (AD) is a neurodegenerative disorder of an ever-increasing aging population with various pathological features such as beta-amyloid (Abeta) aggregation, oxidative stress, an impaired cholinergic system, and neuroinflammation."], ['Macronutrients deficiencies could cause kwashiorkor, marasmus, ketosis, growth retardation, wound healing, and increased infection susceptibility, whereas micronutrient - like iron, folate, zinc, iodine, and vitamin A - deficiencies lead to intellectual impairment, poor growth, perinatal complications, degenerative diseases associated with aging and higher morbidity and mortality.'], ['mtDNA-induced inflammation promotes autoimmune- and aging-related degenerative disorders.', 'Taken together, beyond revealing the central role of cristae architecture to prevent mtDNA release and inflammation, our results mechanistically link mitochondrial cristae disorganization and inflammation, two emerging hallmarks of aging and aging-related degenerative diseases.'], ["Aging is a crucial risk factor for common neurodegenerative diseases, such as Alzheimer's disease (AD) and Parkinson's disease (PD).", 'These favorable effects may also be employed in neurodegenerative diseases.', 'Herein, we reviewed the recent progress, both in preclinical studies and clinical trials, regarding these clinically used GLP-1R agonists in aging-related neurodegenerative diseases, mainly AD and PD.'], ['Predicting brain aging can help in the early detection and prognosis of neurodegenerative diseases.'], ["BACKGROUND AND OBJECTIVES: Olfactory function declines with aging and olfactory deficits are one of the earliest features of neurodegenerative diseases, such as Parkinson's disease and Alzheimer's disease."], ["Alzheimer's disease (AD), a devastating neurodegenerative disorder (characterized by a progressive impairment of cognitive functions) in the elderly, is often co-morbid with chronic pain.", 'AD is one of the most common neurodegenerative disorders in the aged population.'], ['Altered oscillations in brain activity during sleep is an early feature of neurodegenerative diseases and be used to identify those on the verge of cognitive decline.', 'The findings strengthen the concept of sleep as a window into neurodegenerative diseases.'], ['Recent conceptualizations view BD as a neurodegenerative disorder characterized by progressive deterioration of grey and white matter (GM, WM) volumes and accelerated brain ageing.'], ["Alzheimer's disease (AD) is the most prevalent neurodegenerative disease caused by the deposition of amyloid beta (Abeta) fibrils forming extracellular plaques and the development of neurofibrillary tangles (NFT) of intracellular hyperphosphorylated tau protein."], ["Positron emission tomography (PET) with 18F-PM-PBB3 (18F-APN-1607, 18F-Florzolotau) enables high-contrast detection of tau depositions in various neurodegenerative dementias, including Alzheimer's disease (AD) and frontotemporal lobar degeneration (FTLD).", 'The methodology for determining reference tissues as optimized here improves the accuracy of 18F-PM-PBB3-PET measurements of tau burdens in a wide range of neurodegenerative illnesses.'], ['As various degenerative diseases are associated with accumulating DNA damage, defining the effects of complementary E* exposures on selenoenzyme activities may enhance the ability of preventative medicine to support healthy aging.'], ['The apparent evolution to a progressive course reflects a partial shift from predominantly localised acute injury to widespread inflammation and neurodegeneration, coupled with failure of compensatory mechanisms, such as neuroplasticity and remyelination.'], ["Alzheimer's disease (AD) is an irreversible neurodegenerative brain disorder that degrades the memory and cognitive ability in elderly people."], ["PRACTICAL APPLICATIONS: Alzheimer's disease (AD) is a degenerative neurological disorder characterized by cognitive and behavioral dysfunction."], ['Central nervous system (CNS) atrophy provides valuable additional evidence of an ongoing neurodegeneration independent of lesion accrual in persons with multiple sclerosis (PwMS).', "The following recommendations were created based on application of patient's and provider's surveys, and various workshops held over a period of 2 years: (1) PwMS should receive basic information on understanding of brain functional anatomy, and explanation of inflammation and neurodegeneration; (2) the expertise for atrophy measurements should be characterized as evolving; (3) quality patient education materials on these topics should be provided; (4) the need for standardization of MRI exams has to be explained and communicated; (5) providers should discuss background on volumetric changes, including references to normal aging; (6) the limitations of brain volume assessments at an individual-level should be explained; (7) the timing and language used to convey this information should be individualized based on the patient's background and disease status; (8) a discussion guide may be a very helpful resource for use by providers/staff to support these discussions; (9) understanding the role of brain atrophy and other MRI metrics may elicit greater patient satisfaction and acceptance of the value of therapies that have proven efficacy around these outcomes; (10) the areas that represent possibilities for positive self-management of MS symptoms that foster hope for improvement should be emphasized, and in particular regarding use of physical and mental exercise that build or maintain brain reserve through increased network efficiency, and (11) an additional time during clinical visits should be allotted to discuss these topics, including creation of specific educational programs."], ['Objective: To assess racial and ethnic disparities in magnetic resonance imaging (MRI) markers of cerebrovascular disease and neurodegeneration in midlife and late life.'], ['Myriads of clinico-phenotypic features, including intellectual disability, early aging and neurodegeneration, and Alzheimer disease (AD)-related dementia are inevitable in DS-population where mitochondrial dysfunctions play the central role.'], ['OBJECTIVE: Differentiating iNPH from other neurodegenerative diseases is challenging.'], ['Demyelination is observed in both healthy aging and age-related neurodegenerative disorders.'], ["Neuroinflammation (NF) is defined as the activation of brain glial cells that are found in neurodegenerative diseases including Alzheimer's disease (AD)."], ['These results suggest that cerebral neurodegenerative and microvascular lesions are common neuropathologies linking anosmia with MCI in older adults.'], ["Alzheimer's disease (AD), the most common type of senile dementia, is a chronic neurodegenerative disease characterized by cognitive dysfunction and behavioral disability."], ['Exposures: Neuropathologic examination identified the presence of macroscopic and microscopic infarcts, atherosclerosis, arteriolosclerosis, cerebral amyloid angiopathy, and common neurodegenerative pathologies (Alzheimer disease, limbic-predominant age-related transactive response DNA-binding protein 43 encephalopathy, and Lewy bodies).', 'In linear regression models adjusted for demographics and neurodegenerative pathologies, macroscopic infarcts were associated with greater scam susceptibility (estimate [SE], 0.18 [0.07]; P = .009).', 'Conclusions and Relevance: Cerebrovascular pathologies, specifically cerebral infarcts, is linked with greater scam susceptibility in older adults, independent of common neurodegenerative diseases such as Alzheimer disease.'], ['We discovered changes in iron and oxygen homeostasis-related gene expression associated with aging of the brain, and identified dysregulated expression of rare Neurodegeneration with Brain Iron Accumulation (NBIA) genes associated with tau pathology to distinguish PSP from the healthy ageing brain.', 'Our findings reveal potential novel targets for therapy development and have implications beyond PSP for other iron-associated neurodegenerative diseases.'], ["In particular, neurodegenerative disorders including Alzheimer's and Parkinson's disease constitute a major health and socio-economic challenge with increasing incidence in many industrialized countries with aging populations.", 'Further, the ideal candidates for these treatments would be at-risk, or premanifest persons in whom the pathological process of the neurodegenerative disorder has begun, but who are clinically normal and extremely difficult to identify.', 'This review summarizes the current implementation of these imaging biomarkers and the implications for future management of neurodegenerative disorders and CNS drug development in general.'], ['Indeed, many studies investigating gut microbiota have been performed and have shown strong associations between specific microorganisms and metabolic diseases including overweight, obesity, and type 2 diabetes mellitus as well as specific gastrointestinal disorders, neurodegenerative diseases, and even cancer.'], ['The findings are discussed in the context of theories of cognitive ageing and are compared to those found in neurodegenerative disease.'], ['Subclinical depressive symptoms in ageing are linked with neurodegeneration biomarkers in the frontolimbic network including brain areas particularly sensitive to AD.', 'The relationship between depressive symptoms and AD may be partly underpinned by neurodegeneration in common brain regions.'], ["Brain iron deposition is a promising marker for human brain health, providing insightful information for understanding aging as well as neurodegenerations, e.g., Parkinson's disease (PD) and Alzheimer's disease (AD).", 'To comprehensively evaluate brain iron deposition along with aging, PD-related neurodegeneration, from prodromal PD (pPD) to clinical PD (cPD), and AD-related neurodegeneration, from mild cognitive impairment (MCI) to AD, a total of 726 participants from July 2013 to December 2020, including 100 young adults, 189 old adults, 184 pPD, 171 cPD, 31 MCI and 51 AD patients, were included.', 'In conclusion, progressive iron deposition in the SN and RN may characterize PD-related neurodegeneration, namely aging to cPD through pPD.', 'On the other hand, extreme iron deposition in the caudate and putamen may characterize AD-related neurodegeneration.'], ['Importantly, nucleolar alterations are a prominent feature of multiple human pathologies, including cancer and neurodegeneration, as well as being associated with aging.'], ["We examine novel biomarkers potentially associated with delirium, including inflammation, Alzheimer's disease (AD) pathology and neurodegeneration, neuroimaging markers, and neurophysiologic markers."], ['The implications of these findings are discussed in the context of the growing literature on CSF circulatory dysfunction in neurodegeneration and cerebrovascular disease.'], ['Specific thalamic nuclei are implicated in healthy aging and age-related neurodegenerative diseases.'], ['OBJECTIVE: Osteoarthritis (OA) is one of the most common degenerative joint diseases and is associated with autophagy suppression.'], ['Of particular importance, sleep spindles are transient oscillatory events associated with memory consolidation, which are altered in aging and in several psychiatric and neurodegenerative disorders.'], ['It remains unclear, however, how to interpret its scores over time and distinguish age-associated cognitive decline (AACD) from early neurodegeneration.'], ['However, sometimes it can be associated with the decline of cognitive functions, and it is considered a warning for the early stage of neurodegenerative diseases and social impairment.'], ['This neurodegenerative disease process is classically divided into two different pathologies cerebral accumulation of amyloid-beta and hyperphosphorylated neurofibrillary tau tangles.'], ["The aim of this cross-sectional study was to examine whether a history of selective estrogen receptor modifiers (SERMs), tamoxifen and raloxifene, use was associated with cognitive performance, odds of mild cognitive impairment (MCI), or magnetic resonance imaging (MRI) markers of neurodegeneration associated with Alzheimer's disease."], ['Therapeutic strategies enhancing lysosomal function are a promising approach for aging and age-related neurodegenerative diseases.'], ['Age-related macular degeneration (AMD) is a progressive neurodegenerative disease affecting the central area (macula lutea) of the retina.', 'Recent studies suggested that microbiota is a transducer and a modifier of risk factors for neurodegenerative diseases, and mitochondria may be one of the intracellular targets of microbial signaling molecules.', 'These findings support an emerging concept that microbiota-mitochondria disorders may be a crucial pathogenic mechanism of early AMD; and similarly, to other age-related neurodegenerative diseases, new treatment approaches should be targeted at these disorders.'], ["The examination of AD biomarkers and physical functioning may allow for the development of risk profiles, which could stratify a person's risk for neurodegenerative diseases, such as AD, based upon plasma AD biomarkers, physical functioning, ethnicity or a combination of these measures prior to the onset of cognitive impairment."], ["Using three large cohorts of cognitively unimpaired older adults, the Anti-Amyloid Treatment in Asymptomatic Alzheimer's and companion study, Longitudinal Evaluation of Amyloid Risk and Neurodegeneration (N = 447), the Alzheimer's Disease Neuroimaging Initiative (N = 420), and the Harvard Aging Brain Study (N = 190), we attempt to identify regions with high rates of tau accumulation and estimate how these rates evolve over a continuous spectrum of baseline amyloid deposition."], ['Studies with older people have shown a relationship between neurodegenerative diseases and CoQ10 levels.'], ["Hypoxia, that is, an inadequate oxygen supply, is linked to neurodegeneration and patients with cardiovascular disease are prone to Alzheimer's disease (AD)."], ['Nowadays, it becomes of paramount societal importance to support many frail-prone groups in our society (elderly, patients with neurodegenerative diseases, etc.)'], ['Neurodegenerative diseases (NDs) have become a significant threat to an aging human society.'], ["BACKGROUND: Alzheimer's disease (AD) is a chronic neurodegenerative disease and the most common form of dementia, especially in the elderly.", 'In this sense, recent studies indicate that the dual-specificity tyrosine phosphorylation regulated kinase 1A (DYRK1A) gene, which is located on chromosome 21q22.2 and overexpressed in Down syndrome (DS), may play a significant role in developmental brain disorders and early onset neurodegeneration, neuronal loss and dementia in DS and AD.', 'Inhibiting DYRK1A may serve to stop the phenotypic effects of its overexpression and, therefore, is a potential treatment strategy for the prevention of age-associated neurodegeneration, including Alzheimer-type pathology.'], ['Older people are more susceptible to these events, due to the continuing search for several chronic degenerative disease treatments.'], ["We review literature on the progressive neurodegenerative disorder, Alzheimer's disease, as an example of pathological cognitive aging in which human females show greater lifetime risk, neuropathology, and cognitive impairment, compared to human males."], ['INTRODUCTION: Neurodegeneration and cognitive decline in aging are growing public health concerns.', 'This study investigates associations between central retinal arteriolar and venular equivalents (CRAE, CRVE) and brain-aging, a sensory and cognitive test composite measure, and macular ganglion cell-inner plexiform layer (mGCIPL) thickness, a biomarker of neurodegeneration.', 'These associations point to potential usefulness of retinal vessel measurements to identify people at higher risk of sensorineural declines and neurodegeneration.'], ['We assess the association between indication for hospitalization and brain neurodegeneration.'], ["Alzheimer's disease (AD), a progressive neurodegenerative disorder, has emerged as the most common form of dementia in the elderly."], ["Alzheimer's disease (AD), an extensive age-associated neurodegenerative disorder.", 'Multi-targeting approaches by means of general antioxidant and anti-inflammatory mechanisms allied with particular receptor and/or enzyme-mediated actions in neuroprotection and neurodegeneration.', 'The definitive goal of AD investigation is to avert the onset of neurodegeneration; thereby it allows successful aging devoid of cognitive decline.'], ['cortical thickness) may not be sensitive to early stages of neurodegeneration.'], ['Neurodegeneration is a degenerative process characterized by the progressive loss of the structure and function of neurons that involves several immune cells.', 'It is the primary cause of dementia and other several syndromes, known as neurodegenerative diseases.', "In particular, several compounds such as astaxanthin, baicalein, glycyrrhizin, St. John's wort, and Ginkgo biloba L. extracts show particular neuroprotective and immunomodulatory abilities, involving several immune cells and some neurotransmitters that play a critical role in neurodegeneration, making them particularly useful in improving the symptoms and progression of neurodegenerative diseases."], ["Huntington's disease (HD) is a neurodegenerative disorder caused by CAG expansions in the huntingtin (HTT) gene."], ['Besides the increased infectious burden, older individuals also have heightened risks of metabolic and neurodegenerative diseases, which have an immunological component.'], ['Neurodegenerative disorders (NDs) are highly prevalent among the aging population.', 'Due to the unavailability of specific therapeutics and diagnostics, the necessity to control or manage NDs raised the demand to investigate and develop efficient alternative approaches.', 'Keeping trends and advancements in view, this report describes both state-of-the-art and challenges in nano-biotechnology-based approaches to manage NDs, toward personalized healthcare management.', "These advancements are useful to design future therapy based on the severity of the patient's neurodegenerative disease.", 'However, we observe a lack of knowledge shared among scientists of a variety of expertise to explore this multi-disciplinary research field for NDs management.', 'Consequently, this review will provide a guideline platform that will be useful in developing novel smart nano-therapies by considering the aspects and advantages of nano-biotechnology to manage NDs in a personalized manner.'], ['DNA damage and DNA repair deficits are linked to ageing and neurodegeneration, and transient neuronal DNA double-strand breaks (DSBs) also occur as a result of neuronal activity.'], ['Collectively, these data suggest the energetic cost of walking may be an early marker of neurodegeneration that contributes to the gait brain connection.'], ['Method: Measurement invariance for sex and education was explored in a brief telephone-administered cognitive battery from the Canadian Longitudinal Study on Aging (CLSA; after excluding persons with neurological conditions N = 12,350 responded in English and N = 1,760 in French).'], ['Sub analysis of patients with degenerative disease showed no difference in long-term survival after propensity weighting (HR 1.4; 95%CI 0.84 - 2.50; p=.282).'], ['OBJECTIVES: Subjective cognitive difficulties in the elderly may serve as potential risk-factors for future, objective decline and conversion to neurodegenerative disorders (e.g., mild cognitive impairment [MCI] and dementia).'], ['Stroke is the leading cause of epilepsy in the elderly, ahead of degenerative diseases, tumors and head injuries.'], ['However, autophagy is commonly altered and compromised in several diseases, including neurodegenerative disorders.'], ['VA deficiency (VAD) increases the risk of neurodegeneration in animal models, but results are inconclusive in humans: particularly in the older adult (OA) population which is at higher risk for micronutrient deficiencies and cognitive impairment.'], ['Applause sign (AS) was shown to be an indicator of frontal subcortical dysfunction in many neurodegenerative diseases.'], ['BACKGROUND: The prevalence of age-related neurodegenerative diseases has risen in conjunction with an increase in life expectancy.'], ['Altered protein folding leading to the formation of structured aggregates such as amyloid fibrils has gained significant attention due to its association with neurodegenerative diseases.', 'Our results suggest that the generic antiamyloid property of chaperone-like proteins, such as alpha-crystallin, can be harnessed to design protein and peptide-based novel therapeutics for prevention and treatment of deadly neurodegenerative diseases.'], ['The modeling of neuropathology on induced neurons obtained by cell reprogramming technologies can fill a gap between clinical trials and studies on model organisms for the development of treatment strategies for neurodegenerative diseases.'], ["Parkinson's disease (PD) is the second most common neurodegenerative disorder in the aging population, and no disease-modifying therapy has been approved to date."], ['The formation and accumulation of advanced glycation end products (AGEs) have been associated with aging and the development, or worsening, of many degenerative diseases, such as atherosclerosis, chronic kidney disease, and diabetes.'], ["These distinct neural signatures of aging and behavior can potentially be used to identify 'super-agers', or individuals at risk for cognitive decline due to aging or neurodegenerative disease."], ['Our findings complement previously described CVRF-related changes in brain water diffusion properties pointing towards myelin loss and neuroinflammation rather than neurodegeneration.'], ['Objective: Strong evidence supports the benefits of exercise for healthy ageing, including reduced risk of neurodegenerative diseases.'], ['Since the hallmarks of aging were summarized in 2013, increasing studies focus on the role of mitochondrial dysfunction in aging and aging-related degenerative diseases, such as neurodegenerative diseases, osteoarthritis, metabolic diseases, and cardiovascular diseases.', 'In this paper, we provide an overview of mitochondrial changes during aging and summarize the advanced studies in mitochondrial therapies for the treatment of degenerative diseases.'], ['BACKGROUND: During biological aging, significant metabolic dysregulation in the central nervous system may lead to cognitive decline and neurodegeneration.'], ['Dementia is the most common neurodegenerative disease in the aging population.'], ['Moreover, transcriptome-wide analyses are starting to reveal changes in messenger RNA modifications in neurodegenerative diseases and in the expression of some RNA modifiers with age.'], ['Conclusions and Relevance: In this cohort study, early adulthood hypertension and BP change were associated with late-life volumetric and WM differences implicated in neurodegeneration and dementia.'], ['However, few longitudinal studies have explored the relationship between sleep habits and imaging markers of brain health, particularly markers of brain waste clearance such as perivascular spaces (PVS), of neurodegeneration such as brain atrophy, and of vascular disease, such as white matter hyperintensities (WMH).'], ['Information of these changes should also be included in future longitudinal studies to investigate different pathways from normal cognitive aging to the cognitive decline characterizing different stages of AD and other neurodegenerative disorders.'], ["FUNDING: AC Immune, La Caixa Foundation, Instituto de Salud Carlos III, National Institute on Aging, Wellcome Trust, Jerome Lejeune Foundation, Medical Research Council, Alzheimer's Association, National Institute for Health Research, EU Joint Programme-Neurodegenerative Disease Research, Alzheimer's Society, Deutsche Forschungsgemeinschaft, Stiftung fur die Erforschung von Verhaltens, Fundacion Tatiana Perez de Guzman el Bueno & European Union's Horizon 2020 und Umwelteinflussen auf die menschliche Gesundheit."], ["Alzheimer's disease (AD) is a common neurodegenerative disease that tends to occur in the elderly."], ['BACKGROUND: Polyphenols have been shown to be effective against many chronic diseases, including neurodegenerative diseases.'], ['Chronic low-grade systemic inflammatory conditions, such as obesity, exacerbate this decline beyond normal ageing and predispose individuals to neurodegenerative diseases, such as dementia.'], ['Mutations in Polbeta can lead to cancer, neurodegenerative diseases, or premature aging.'], ['Glycation and the accumulation of advanced glycation end-products (AGEs) are known to occur during aging, diabetes and neurodegenerative diseases.'], ['The determining role that environmental factors such as diet and lifestyle play on health, life expectancy, and susceptibility to diseases, including cancer and neurodegenerative diseases, is wellestablished.'], ["Old age increases the risk of Alzheimer's disease (AD), the most common neurodegenerative disease, a devastating disorder of the human mind and the leading cause of dementia."], ['However, longevity is accompanied by an accretion in the frequency of age-related neurodegenerative diseases, creating a growing burden, with pervasive social impact for human societies.', 'Its anatomical transparency allows the use of co-expressed fluorescent proteins to track the progress of neurodegeneration.', 'Moreover, the functional conservation of neuronal processes, along with the high homology between nematode and human genomes, render C. elegans extremely suitable for the study of human neurodegenerative disorders.', 'This review describes nematode models used to study neurodegeneration and underscores their contribution in the effort to dissect the molecular basis of human diseases and identify novel gene targets with therapeutic potential.'], ["Aging is an irreversible physiological process in the human body, and the aging characteristics of the body that accompany this process also lead to many other chronic diseases, such as neurodegenerative diseases represented by Alzheimer's disease and Parkinson's disease, cardiovascular diseases, hypertension, obesity, cancer, and so on."], ['Until 2016 - when the results of previous human studies were reviewed - a vast majority of the studies had dealt with age-related neurological diseases, like cerebrovascular and neurodegenerative diseases, multiple sclerosis, as well as some other common diseases in elderly such as migraine, traumatic brain injury and post-traumatic stress disorder, chronic hepatitis and nephrotic syndrome.'], ['Phase separation has been implicated as an important mechanism of protein aggregation diseases, such as neurodegeneration.'], ['It is characterized by progressive cognitive decline and neurodegeneration.'], ['The present approach opens a novel way to the analysis of resting-state fMRI with possible applications for understanding the brain dynamics during aging or neurodegeneration.'], ["A reduction in its function due to ageing has been associated with the development of Alzheimer's disease (AD), a common neurodegenerative disorder characterised by the deposition of neurotoxic amyloid plaque in the brain and cerebral vessel walls."], ['As an apparent model of normative human aging, the macaque is ideal for studying induction and mitigation of neurodegenerative disease.'], ['BACKGROUND: Osteoarthritis (OA) is the most common degenerative disease in joints among elderly patients.'], ['Neurodegenerative diseases are complex multifactorial conditions for which no effective treatments are currently available.', 'Animal models are necessary to understand the causes and progression of neurodegeneration.', 'Nonhuman primates (NHPs) offer significant advantages for the study of neurodegenerative disease.', 'In this review, we discuss the current literature on the use of marmosets as a model of aging and neurodegeneration.', 'We highlight aspects of marmoset physiology associated with aging, such as metabolic alterations, which may help understand their vulnerability to developing a neurodegenerative phenotype that goes beyond normal aging.'], ['Therefore, we would recommend daily supplementation of vitamins (folic acid, B vitamins, VD, CoQ10), especially group B vitamins, as a potential preventive measure to slow cognitive decline and neurodegeneration in the elderly.'], ["Alzheimer's disease (AD) is an aging-related neurodegenerative disease, leading to the progressive loss of memory and other cognitive functions."], ["Aging and metabolic syndrome are associated with neurodegenerative pathologies including Alzheimer's disease (AD) and there is growing interest in the prophylactic potential of probiotic bacteria in this area.", 'In this study, we assessed the neuroprotective potential of the Lab4P probiotic consortium in both age and metabolically challenged 3xTg-AD mice and in human SH-SY5Y cell culture models of neurodegeneration.'], ["Aging-related diseases include focal ischemic stroke and neurodegenerative diseases such as Alzheimer's disease (AD) and Parkinson's disease (PD)."], ['Over 25% reported having contact with >50 patients with dementia or neurodegenerative disease annually.'], ['The question, therefore, arose as to whether our results could possibly be the basis for processes, such as aging/preaging, or, in this context, neurodegeneration.'], ["OS is important not only in relation to aging but also due to its strong impact on neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), Alzheimer's disease (AD), and Parkinson's disease (PD).", 'In this review, we will discuss the aging process in relation to OS, the function of OS in neurodegenerative disorders, and prospective therapeutics capable of relieving neurodegenerative symptoms associated with the pro-oxidative condition.'], ['Optimizing neighbourhood residential density maybe one of the upstream considerations for mitigating against neurodegenerative diseases.'], ['Aging is also a primary risk factor for most neurodegenerative diseases.', 'However, the causal connections among microbiome, amyloid-tau interaction, and neurodegeneration need to be addressed.', 'This paper summarizes the emerging evidence in the literature regarding the link between the oral and gut microbiome and neurodegeneration with a focus on AD.', 'Together, all this evidence suggests that, in some sense, gut microbiota can be seen as an additional hallmark of human aging and neurodegeneration.'], ['Sirtuins are NAD+-dependent deacetylases with beneficial roles in conditions relevant to human health, including metabolic disease, type II diabetes, obesity, cancer, aging, neurodegenerative diseases and cardiac ischemia.'], ['Although poor sleep quality and extreme sleep durations have been associated with brain atrophy and dementia, it is unclear whether sleep disturbances contribute to neural injury in the absence of neurodegeneration and cognitive impairment.'], ['Furthermore, transfer of gut microbiota from healthy individuals to patients can reshape the gut microbiota structure and thus holds the potential to be exploited for the treatment of various neurodegenerative disease.'], ['BACKGROUND: Cerebral venous outflow alterations contribute to central nervous system pathology in aging and neurodegenerative disorders and are potentially linked to underlying cerebral microangiopathy.'], ['Neurofilament light chain (NfL), a neuron-specific protein, has been related to several neurodegenerative diseases.', 'In addition, elevated levels of NfL have also been observed in patients admitted to the hospital for stroke, suggesting that NfL as a biomarker may extend well beyond neurodegenerative diseases.'], ["Olfactory dysfunction is a prevalent symptom and an early marker of age-related neurodegenerative diseases in humans, including Alzheimer's and Parkinson's Diseases."], ["Memory decline is one of the most disabling features observed during normal aging and age-associated neurodegenerative disorders namely Alzheimer's disease (AD) and Parkinson's disease (PD), etc."], ["Alzheimer's disease is one of the common neurodegenerative diseases in the elderly, which mainly manifests as progressively severe cognitive impairment, which seriously affects the quality of life of patients."], ['CONCLUSIONS: Our experimental findings suggest that Q10 supplementation can suppress the progression of neurodegeneration that otherwise impairs learning and memory and reduces synaptic plasticity in our experimental animals.'], ['Emerging evidence show that mycotoxins may induce human neurodegenerative diseases (ND); however, this idea is still unproven.'], ['Axonal loss and demyelination may co-occur with neurodegeneration and astrogliosis ahead of clinically meaningful cognitive decline.'], ['Overnutrition is a risk factor for various human diseases, including neurodegenerative diseases, metabolic disorders, and cancers.', 'Fasting can slow aging in most species and protect against various human diseases, including neurodegenerative diseases, metabolic disorders, and cancers.'], ['It is closely related to the occurrence and development of cancer, neurodegenerative diseases, and aging-related diseases.'], ['Both hippocampal sclerosis and TDP-43 proteinopathy have also been described in chronic traumatic encephalopathy (CTE), a neurodegenerative disease linked to exposure to repetitive head impacts (RHI).'], ["Aging and neurodegenerative disorders, such as Alzheimer's disease (AD), trigger an immune response known as glial activation in the brain."], ["The estrogen/ERalpha pathways are affected by the reduction of estrogens in menopause, and this event may be a risk factor for neurodegeneration associated with Alzheimer's disease in women."], ['Therefore, it is important to understand how age-associated changes in ECM affect accumulation of pathogenic molecules, neuroinflammation, and neurodegeneration in AD patients and in vitro models.'], ["Parkinson's disease (PD) is a degenerative disorder of the central nervous system that affects 1% of the population over the age of 60."], ["Parkinson's disease (PD) is a progressive neurodegenerative disease associated with loss of dopaminergic neurons in the substantia nigra pars compacta.", 'Dihydromyricetin (DHM), a flavonoid derived from Asian medicinal plant, has also shown effectiveness against oxidative damage and neuroinflammation, hallmarks of neurodegenerative diseases.'], ['Cp deficiency especially affected the function of proteins involved in the extension of neuronal projections, synaptic signalling, and cellular mRNA processing, and affected the expression of proteins involved in neurodegenerative disease and diabetes.'], ['BACKGROUND CONTEXT: Dysphagia is one of the postoperative complications of cervical degenerative disorders.'], ["Alzheimer's disease (AD) is one of the progressive neurodegenerative disorders and the most common cause of dementia in the elderly worldwide causing difficulties in the daily life of the patient."], ['Today, the diagnosis and follow-up of all neurodegenerative diseases cannot be performed without radiological imaging, primarily magnetic resonance imaging (MRI).'], ['Circadian rhythms alter with ageing and may be aetiologically linked to neurodegeneration.'], ['Osteoarthritis (OA), one of the major diseases afflicting the elderly, is a type of degenerative joint disease related to cartilage and synovium.'], ['CONCLUSION: The present work provides the basis for future scientific research focused on the dynamic nature of PG calcium deposits and PG soft tissue in normal aging and neurodegenerative diseases.'], ['Here we describe a pathomechanism that might be relevant for our understanding of impaired development and aging-associated neurodegeneration.'], ['Chronic inflammation is frequently invoked as a mechanism of neurodegeneration and yet inflammatory cell infiltrates are seldom seen in brains of these disorders.', 'This IIR without immune cell infiltration leads to neurodegeneration through non-canonical pathways that may accentuate normal aging pathways.'], ["INTRODUCTION: The Alzheimer's disease (AD) continuum begins with a long asymptomatic or preclinical stage, during which amyloid beta (Abeta) is accumulating for more than a decade prior to widespread cortical tauopathy, neurodegeneration, and manifestation of clinical symptoms."], ["Neurodegenerative diseases, including Alzheimer's and Parkinson's disease, are major age-related concerns in elderly people.", 'Since no drug fully addresses the progression of neurodegenerative diseases, advance treatment strategies are urgently needed.', 'This review describes the health-beneficial effects of paraprobiotics in age-associated neurodegenerative diseases.'], ['DISCUSSION: The neural activity changes associated with performance improvement during dual tasking hold promise as cognitive flexibility markers that can potentially help assess cognitive decline in aging and neurodegeneration.'], ['Animal models are employed to investigate the cellular and molecular mechanisms of brain aging and age-related neurodegenerative diseases that underlie cognitive decline.'], ['Common neurological disorders, including neurodegenerative diseases, stroke, epilepsy, autism and psychiatric disorders, affect many people worldwide and threaten their lives and health by inducing movement disorders, behavioral disorders, or a combination of both.', 'In addition, protein homeostasis (proteostasis) impairment occurs in many neurodegenerative diseases, which plays a critical role in the progression of the pathology.', 'Since impaired proteostasis is closely involved in all amyloid diseases, particularly neurodegenerative diseases, grape seeds extract can be a valuable therapeutic agent.'], ['BACKGROUND: Knee osteoarthritis, a chronic degenerative disease, is becoming a public health problem around the world due to increasing life expectancy.'], ['RESULTS: Among Mexican Americans, age (OR = 1.07), depression (OR = 1.09), and MRI-based neurodegeneration (OR = 0.01) were associated with dementia, but none of these factors were associated with MCI.', 'Among non-Hispanic whites, male gender (OR = 0.33), neighborhood deprivation (OR = 1.34), depression (OR = 1.09), and MRI-based neurodegeneration (OR = 0.03) were associated with MCI, while depression (OR = 1.09) and APOEe4 genotype (OR = 4.38) were associated with dementia.'], ["Alzheimer's disease (AD) is the most common progressive neurodegenerative disease associated with advanced age."], ['Background: Knee osteoarthritis, a chronic and degenerative joint disease, is more common among the growing elderly population.'], ["alpha-Synuclein (alphaSyn) plays a major role in the pathogenesis of Parkinson's disease (PD), which is the second most common neurodegenerative disease after Alzheimer's disease.", 'Among the various model systems, Drosophila melanogaster has several advantages for modeling human neurodegenerative diseases.'], ["Alzheimer's disease (AD) is the most prevalent and devastating neurodegenerative disease occurred in the elderly."], ["Early diagnosis of neurodegenerative disorders, such as Alzheimer's Disease (AD), is very important to reduce their effects and to improve both quality and life expectancy of patients.", 'A fundamental aspect for the use of these techniques is the definition of effective features, which allows the system to distinguish the natural alterations of handwriting due to age, from those caused by neurodegenerative disorders.'], ['Niemann-Pick C1 (NPC1) is a Mendelian disorder caused by >300 variants in the NPC1 gene that disrupt cholesterol homeostasis leading to the rapid onset and progression of neurodegenerative disease.'], ["PURPOSE: Huntington's disease is an autosomal dominant neurodegenerative disease."], ['METHODS AND FINDINGS: Between July 6, 1989, and January 1, 2012, we followed participants from the prospective Rotterdam Study aged 45 years and older who were free from NCDs at baseline for incident stroke, heart disease, diabetes, chronic respiratory disease, cancer, and neurodegenerative disease.', 'During 75,354 person-years of follow-up from a total of 9,061 participants (mean age 63.9 years, 60.1% women), 814 participants were diagnosed with stroke, 1,571 with heart disease, 625 with diabetes, 1,004 with chronic respiratory disease, 1,538 with cancer, and 1,065 with neurodegenerative disease.'], ["Mutations in the gene encoding the RNA-binding protein TDP-43 cause amyotrophic lateral sclerosis (ALS), clinically and pathologically indistinguishable from the majority of 'sporadic' cases of ALS, establishing altered TDP-43 function and distribution as a primary mechanism of neurodegeneration."], ['However, the trade-off for cancer resistance is ostensibly increased age-related degenerative diseases, principally in the form of atherosclerosis.'], ['Two members of a gene sub-family encoding these proteins, FBXO7 and FBXO32, have been implicated in the onset and progression of degenerative disease.', 'The third gene in this family, FBXO9, is related to growth signaling, but the role of this gene in degenerative disease pathways has not been thoroughly investigated.'], ['Mutation of CSP in flies, worms and mice reduces lifespan and causes synaptic dysfunction and neurodegeneration.', 'Furthermore, recent studies have revealed that the neurodegenerative disease, adult onset neuronal ceroid lipofuscinosis, is caused by mutations in the human CSPalpha-encoding DNAJC5 gene.', 'Accumulating evidence suggests that the major mechanism by which CSP prevents neurodegeneration is by maintaining the conformation of SNAP-25, thereby facilitating its entry into the membrane-fusing SNARE complex.', 'In this review, we focus on the role of CSP in preventing neurodegeneration and discuss how recent studies of this universal neuroprotective chaperone are being translated into potential novel therapeutics for neurodegenerative diseases.'], ['Transient neurological deterioration occurred in 6 patients (5.9%).'], ["In recent years, iron has been regarded as a common pathological feature of many neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD) and Friedreich's ataxia (FRDA).", 'A number of genes involved in iron transport, storage and regulation have been found associated with initiation and progression of neurodegeneration.', 'Due to the limitation in transgenic rodent model construction and transfection systems, the progress in unraveling the pathogenic role of different iron-related proteins in neurodegenerative diseases has been slow.', 'Drosophila melanogaster, a simple organism which has a shorter lifespan and smaller genome with many conserved genes, and captures many features of human nervous system and neurodegeneration, may help speed up the progress.', 'It is believed that identification of important iron-related genes that can largely stop or even reverse degenerative process in Drosophila models may lead to development of novel therapeutic strategies against neurodegenerative diseases.'], ['In recent years mounting evidence has indicated the implication of these proteins in several mitochondrial diseases including neurodegenerative disorders, myopathies and Type II diabetes mellitus.'], ['PURPOSE OF REVIEW: To summarize key studies and recent thought on the role of neuroinflammation in chronic neurodegeneration, and whether it can be modulated by anesthesia and surgery.', "RECENT FINDINGS: A large and growing body of evidence shows that neuroinflammation participates in the development of neurodegeneration associated with Alzheimer's disease.", 'The peripheral inflammatory response elicited by surgery itself appears to provoke a muted neuroinflammatory response, which enhances ongoing neurodegeneration in some models.', 'Human studies at the intersection of chronic neurodegeneration, neuroinflammation, and surgery/anesthesia are rare.', 'SUMMARY: The perioperative period has the potential to modulate the progression of chronic neurodegenerative diseases.'], ['In addition, a potent and selective SIRT2 inhibitor that ameliorates the alpha-synuclein fibril formation in Parkinson disease has been proposed to treat this kind of neurodegenerative disease.'], ['Niemann-Pick C disease is a fatal progressive neurodegenerative disorder caused in 95% of cases by mutations in the NPC1 gene; the remaining 5% of cases result from mutations in the NPC2 gene.'], ['Although massive neurodegeneration occurred in 1-yr-old mice expressing SOD1(G37R) alone, spinal root axons and motor neurons were remarkably spared in doubly SOD1(G37R);NF-H-transgenic littermates.'], ['Although antibodies to alpha- and beta-synucleins detected abnormal dystrophic neurites in the OE of patients with neurodegenerative disorders, similar pathology was also seen in the OE of controls.'], ['INTRODUCTION: Communicating the diagnosis of a genetic and neurodegenerative disease, such as spinal muscular atrophy (SMA), requires a transmission centered on the patient and/or the family caregiver, ensuring autonomy to those involved and strengthening the doctor-patient relationship.', 'Future research evaluating other neurodegenerative diseases and the development of research protocols are important to improving communication between physicians, patients, and family members.'], ['Autosomal dominant adult-onset neuronal ceroid lipofuscinosis (ANCL) is a rare neurodegenerative disorder characterised by progressive dementia and premature death.'], ["Considerable diseases still with undefined etiology, such as neurodegenerative conditions, and Huntington's Disease (HD) is one of them."], ["Increased levels of IL-1, IL-6, and TNF in the AD's and PD's patients can be regarded evidence of systemic inflammation associated with each of these neurodegenerative disorders.", 'One of the primary variables in the progression of neurodegenerative disorders is oxidative stress.', 'Many medicinal plants and their secondary metabolites have been claimed to be able to help people with neurodegenerative disorders like AD and PD.', 'In regard to neurodegenerative disorders, numerable plant-based drugs like alkaloids, iridoids, terpenes, flavones are employed for the treatment.'], ['The emergence of degenerative disease after traumatic brain injury is often described as an acceleration of normal age-related processes.'], ['Among children with neurodegenerative disorders, such as neuronopathic mucopolysaccharidoses (MPS disorders), the effects of the pandemic are likely to be even greater.'], ['Spinal muscular atrophy (SMA), the main genetic cause of infant death, is a neurodegenerative disease characterized by the selective loss of motor neurons in the anterior horn of the spinal cord, accompanied by muscle wasting.'], ['In the brain of patients/animals with NPC, as a consequence of the accumulation of free-C in late endosomes/lysosomes (LE/LY) in cells, multiple lipids including complex sphingolipids are accumulated, and almost all patients/animals ultimately develop progressive/fatal neurodegeneration.'], ['A pathological pathway leading from soluble monomeric to insoluble filamentous Tau is characteristic of many human neurodegenerative diseases, which also exhibit dysfunction and death of brain cells.', 'Murine Tau did not contribute significantly to either Tau aggregation or neurodegeneration.', 'To further study the relevance of filament formation for neurodegeneration, we deleted hexapeptides 275VQIINK280 and 306VQIVYK311, either singly or in combination, from human 0N4R Tau with the P301S mutation.', 'The latter had significant levels of sarkosyl-insoluble Tau in brain and spinal cord, and exhibited neurodegeneration.', 'Mice transgenic for P301S Tau with the hexapeptide deletions failed to show significant levels of sarkosyl-insoluble Tau or neurodegeneration.', 'Taken together, we conclude that beta-sheet assembly of human P301S Tau is necessary for neurodegeneration in transgenic mice.'], ['We have examined in this study whether or not increased expression of clusterin is able to protect neuronal cells against intracellular protein aggregation and cytotoxicity, characteristics that are strongly implicated in a range of neurodegenerative diseases.', 'We therefore conclude that increased expression of clusterin can provide an important defense against intracellular proteotoxicity under conditions that mimic specific features of neurodegenerative disease.'], ['BACKGROUND: Amyotrophic lateral sclerosis (ALS) is a progressive debilitating neurodegenerative disease, with a life expectancy of 3-5 years from first symptom.'], ['Despite our knowledge that palmitoyl-protein thioesterase-1 (PPT1)-deficiency causes INCL, the molecular mechanism(s) of neurodegeneration and the drastically reduced lifespan of these patients remain poorly understood.'], ['Furthermore, our results show that FXTAS in women can also develop as a multisystem neurodegenerative disorder with central and peripheral nervous system involvement, and both motor and mental disturbances.'], ['This review focuses on indications, timing and techniques for mitral valve repair in degenerative disease, emphasising the importance of anatomy in surgical outcomes.'], ['Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease in which there is a progressive loss of motor neurons and their connections to muscle, leading to paralysis.'], ['related to glucocorticoid and interleukin-6 activities) vary during lifespan in either sex in either normalcy or neurodegenerative disorders.', 'In women, instead, at menopausal transition, some changes that may predispose to neurodegeneration occurred.', 'In particular, there was (1) an up-regulation of ERs, and a concomitant increase of IL-6 gene expression, events likely due to the loss of the inhibitory control exerted by estradiol (E(2)); (2) an increase of HGR alpha:HGR beta ratio, indicative of an augmented cortisol activity on HGR alpha not sufficiently counteracted by the inhibitory HGR beta function; (3) a reduced CD36 expression, directly related to the increased cortisol activity; and (4) an augmented plasma cortisol:DHEAS ratio, widely recognized as an unfavorable prognostic index for the risk of neurodegeneration.', "CONCLUSIONS: Menopausal transition is a critical phase of women's life where the occurrence of an unfavorable biological milieu would predispose to an increased risk of neurodegeneration."], ['Furthermore, an elevated baseline TNF-alpha level as well as its increased reactivity to an alpha-adrenergic challenge among HIV-1+ individuals, may lead to additional neurodegeneration.'], ['The limited lifespan of human embryonic brain (HEB) cells hampers their therapeutic use for the treatment of neurodegenerative diseases.'], ['This systematic review examines the effect of photobiomodulation (PBM), the application of red to near infrared light on body tissues, on the neuroinflammatory response and oxidative stress in animal models of neurodegenerative diseases.', 'Neurodegenerative diseases are becoming ever more prevalent in the ageing populations across the Western world, with no disease-modifying or neuroprotective treatment options being available.', 'PBM is a non-invasive therapeutic option that has shown efficacy and promising effects in animal models of neurodegenerative disease; many studies have reported neuroprotection and improved behavioural outcomes.', 'To the best of our knowledge, there has been no previous study that has reviewed the anti-inflammatory and the antioxidant effect of PBM in the context of neurodegeneration.', 'This review has examined this relationship in animal models of a range of neurodegenerative diseases.', 'Our review provides further indication that PBM can be developed into an effective non-pharmacological intervention for neurodegenerative diseases.'], ["Alzheimer's disease (AD) is a progressive neurodegenerative disease that still has no permanent cure."], ["Parkinson's disease (PD) is the second most common neurodegenerative disease, affecting the elderly worldwide and causing significant movement impairments.", 'The lack of specific biomarkers for early diagnosis, as well as medication aimed at addressing the pathogenic mechanisms to decelerate the progression of dopaminergic neurodegeneration, are key roadblocks in the management of PD.'], ['Leigh syndrome is a mitochondrial disease characterized by neurodegeneration, neuroinflammation, and early death.', 'As the disease progresses, there is an increase in neurodegeneration and neuroinflammation, thereby leading to deteriorating neurological symptoms, including motor deficits, breathing alterations, and eventually, death of the animal.'], ['The worms generate DPRs (poly-glycine-alanine [poly-GA], poly-glycine-proline [poly-GP]) and poly-glycine-arginine [poly-GR]), display neurodegeneration, and exhibit locomotor and lifespan defects.'], ["Parkinson's disease (PD) is a progressive neurodegenerative disorder with no known cure.", 'Here, we report that adult ringer mutants display progressive locomotor disabilities, reduced lifespan and neurodegeneration.'], ['Rheumatic heart disease (RHD) still affects more patients globally than degenerative valve disease.'], ['Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease, which involves the progressive degeneration of motor neurons.'], ['This review summarizes the current findings from human and animal studies that detail the impact of maternal obesity on aspects of learning, memory, motivation, affective disorders, attention-deficit hyperactivity disorder, autism spectrum disorders, and neurodegeneration in the offspring.'], ['This increased life expectancy is associated with the occurrence of degenerative diseases, including HIV-associated neurocognitive disorders (HAND), which are diagnosed via a complex neuropsychological assessment.'], ['Perturbations of astrocytes trigger neurodegeneration in several diseases, but the glial cell-intrinsic mechanisms that induce neurodegeneration remain poorly understood.', 'Collectively, our findings define chronic activation of the alpha2-Na/K ATPase/alpha-adducin complex as a critical glial cell-intrinsic mechanism of non-cell autonomous neurodegeneration, with implications for potential therapies for neurodegenerative diseases.'], ['Autophagy is also integral to human health and is involved in physiology, development, lifespan and a wide range of diseases, including cancer, neurodegeneration and microbial infection.'], ['The prevalence of neurodegenerative disorders is rising steadily as human life expectancy increases.', "Recently, differential expression of endogenous regulatory small RNAs, known as 'microRNAs' (miRNAs), in patients of Alzheimer's disease, Parkinson's disease and models of ataxia suggest that they might have key regulatory roles in neurodegeneration.", 'miRNAs that can target known mediators of neurodegeneration offer potential therapeutic targets.', 'Our bioinformatic analysis suggests novel miRNA-target interactions that could potentially influence neurodegeneration.'], ['rhomboid-7 mutant flies have severe neurological defects, evidenced by compromised signaling across the first visual synapse, as well as light-induced neurodegeneration of photoreceptors that resembles the human disease.'], ['Retinal degeneration was present in three patients and associated generalized neurodegeneration was present in two.'], ['Many neurodegenerative disorders display protein aggregation as a hallmark, Huntingtin and TDP-43 aggregates being characteristic of Huntington disease and amyotrophic lateral sclerosis, respectively.'], ['As human life expectancy increases, age-related health issues including neurodegenerative diseases continue to rise.', 'In this review, we describe oxidative damage and mitochondrial dysfunction in glaucoma, an age-related neurodegenerative eye disease affecting 80 million people worldwide.'], ['OBJECTIVE: Amyotrophic lateral sclerosis (ALS) is a progressive debilitating neurodegenerative disease with a life expectancy of 3-5 years from initial symptoms.'], ['Krabbe disease is a rare neurodegenerative disorder caused by a deficiency in galactocerebrosidase.'], ["Alzheimer's disease (AD) is a progressive neurodegenerative disorder."], ['With the increased risk of organ failure and neurodegenerative disease associated with our ability to push the boundaries of life expectancy comes an increased pressure to pioneer novel stem cell-based therapeutic approaches.'], ['Expanded polyglutamine repeats in different proteins are the known determinants of at least nine progressive neurodegenerative disorders whose symptoms include cognitive and motor impairment that worsen as patients age.', 'The polyglutamine expansion destabilizes htt leading to protein misfolding, which in turn triggers neurodegeneration and the disruption of energy metabolism in muscle cells.'], ['Increases in life expectancy and cardiovascular adverse events in patients with hypertension highlight the need for new risk-reduction strategies to reduce the burden of degenerative diseases.'], ['mTORC1 has been implicated in many diseases such as cancer, diabetes, and neurodegeneration, and is a target to prolong lifespan.'], ["Accumulation of the microtubule-binding protein tau is a key event in several neurodegenerative disorders referred to as tauopathies, which include Alzheimer's disease, frontotemporal lobar degeneration, Pick's disease, progressive supranuclear palsy and corticobasal degeneration.", 'Thus, understanding the molecular pathways leading to tau accumulation will have a major impact across multiple neurodegenerative disorders.'], ["Huntington's Disease (HD) is a neurodegenerative disorder that is caused by abnormal expansion of a polyglutamine tract in huntingtin (htt) protein.", 'Here we tested whether overexpression of ubiquilin-1 delays or prevents neurodegeneration in R6/2 mice, a well-established model of HD.'], ["BACKGROUND/AIMS: Parkinson's disease (PD) is a common neurodegenerative disease with a chronic disease course."], ["Alzheimer's disease (AD) is the most common progressive neurodegenerative disease.", 'The AD brain is marked by severe neurodegeneration like the loss of synapses and neurons, atrophy and depletion of neurotransmitter systems in the hippocampus and cerebral cortex.'], ['BACKGROUND: Klotho is a longevity and neuroprotective hormone encoded by the KLOTHO gene, and heterozygosity for the KL-VS variant confers a protective effect against neurodegenerative disease.'], ['BACKGROUND: Poor olfaction is common in older adults and might signify broader health implications beyond its role in neurodegeneration.'], ['The global burden of neurodegenerative disorders is significantly increasing as life expectancy rises but currently there is no cure for these conditions.', 'An extensive search on MEDLINE (PubMed) and PEDro databases was conducted selecting clinical trials, Randomized Controlled Trials, and longitudinal studies published in the last 20 years in order to highlight what evidence there is for a role of spa rehabilitative interventions for patients with neurodegenerative diseases, in terms of motor function, symptoms, and quality of life (QoL) improvement and cost-effectiveness.'], ['alpha/beta-tubulins and SNAP-25 expressions are known to be dysregulated in age-related neurodevelopmental and neurodegenerative disorders.'], ['BACKGROUND: Amyotrophic Lateral Sclerosis (ALS) is a progressive neurodegenerative condition with a mean life expectancy of 3 years from first symptom.'], ['This review provides an assessment of the current state of neurodegeneration treatment due to ischemia-reperfusion brain injury and focuses on the role of curcumin in the diet.', 'Due to the pleotropic properties of curcumin, including anti-amyloid, anti-tau protein hyperphosphorylation, anti-inflammatory, anti-apoptotic, and neuroprotective action, as well as increasing neuronal lifespan and promoting neurogenesis, curcumin is a promising candidate for the treatment of post-ischemic neurodegeneration with misfolded proteins accumulation.', 'In conclusion, the evidence available in a review of the literature on the therapeutic potential of curcumin provides helpful insight into the potential clinical utility of curcumin in the treatment of neurological neurodegenerative diseases with misfolded proteins.', 'Therefore, curcumin may be a promising supplementary agent against development of neurodegeneration after brain ischemia in the future.', 'Indeed, there is a rational scientific basis for the use of curcumin for the prophylaxis and treatment of post-ischemic neurodegeneration.'], ['Interestingly, Ala97Ser TTR overexpression in Drosophila causes late-onset fast neurodegeneration and a relatively short lifespan, recapitulating human disease progression.'], ['Neurodegenerative diseases are multifactorial debilitating disorders of the nervous system affecting approximately 30 million individuals worldwide.', 'Mitochondrial dysfunction and oxidative stress have also been implicated in causing neurodegeneration.', 'As life expectancy is increasing, neurodegenerative disorders are becoming a major social issue.'], ['Hereditary spastic paraplegias refer to a heterogeneous group of neurodegenerative disorders resulting from degeneration of the corticospinal tract.', 'Strikingly, deletion of Ubap1 promotes neurodegeneration, potentially mediated by apoptosis.'], ['Altered flow of CSF, for example, has been shown to impair the clearance of pathogenic inflammatory proteins involved in neurodegenerative diseases, such as amyloid-beta.'], ['RECENT FINDINGS: This article summarizes what is known about the disease course in women with MS, how it differs from men, and the current state of knowledge regarding effects of reproductive exposures (menarche, childbearing, menopause) on MS-related inflammation and neurodegeneration.'], ["Alzheimer's Disease (AD) is an age-related neurodegenerative disorder characterized by progressive cognitive impairments and chronic inflammation that affects over 30 million people all over the world.", 'Unfortunately, the currently available anti-AD drugs provide modest symptomatic relief, and they do not reverse the neurodegeneration.'], ['In agreement with its design, the protective effects of MitoQ appear to be targeted specifically to the mitochondrial membrane and our findings suggest that MitoQ may have therapeutic potential for Abeta- and oxidative stress-associated neurodegenerative disorders, particularly AD.'], ['Neurodegenerative diseases cause tremendous suffering for those afflicted and their families.', 'These and other alterations in the Ubiquitin Pathway observed in neurodegenerative diseases have led to the question of whether impairment of the Ubiquitin Pathway on its own can increase mortality or if ongoing neurodegeneration alters Ubiquitin Pathway function as a side-effect.'], ['Niemann-Pick disease type C (NP-C) is a rare neurovisceral disease characterised by progressive neurological deterioration and premature death, and has an estimated birth incidence of 1:120,000.', 'Epidemiological data suggest that bronchopneumonia subsequent to food or fluid aspiration is a major cause of mortality in NP-C and other neurodegenerative disorders.', 'In this article we present findings from a systematic literature review of published data on bronchopneumonia/aspiration pneumonia as a cause of death, and on the occurrence of dysphagia in NP-C and other neurodegenerative diseases.'], ['Cellular mechanisms involved in neurodegeneration and neuroprotection are continuing to be explored, and this paper focuses on some novel discoveries that give further insight into these processes.', 'The objective of this paper is to invite added research into the newly discovered (or postulated) novel mechanisms; and to stimulate discovery of additional mechanisms attending neurodegeneration and neuroprotection.'], ['Top drug candidates were tested in C. elegans models of neurodegeneration-associated aggregation and in a human neuroblastoma cell-culture model of AD-like amyloidosis.'], ['Recent studies suggest that polymorphic variants of GSTOs affect the onset age and progression of neurodegenerative diseases.', 'Although GSTO activity may affect the development and age dependency of several diseases, the mechanism by which GSTO inactivation in neurons regulates the susceptibility to neurodegenerative diseases is unclear.', 'Drosophila Caz is the ortholog of human FUS, which is associated with neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD).', 'These findings demonstrate that GSTO is a critical modulator of the development of neurodegenerative diseases by regulating Caz localization and aggregation in the nervous system of Drosophila.'], ['The smaller gains in life expectancy for non-Indigenous people were linked with improved survival for those with cancer and neurological conditions.'], ['Brain development and deterioration across the lifespan are integral to the etiology of late-life neurodegenerative disease.'], ['At 60-70 months, we found a clear marker of neurodegeneration: significant cell loss detected in the caudate nucleus, putamen and cortex.', 'In summary, our data demonstrate age-dependent neuropathology with later onset of neurodegeneration in TgHD minipigs.'], ["BACKGROUND: Motor neurone disease (MND) is the term for a group of progressive, debilitating, neurodegenerative disorders that affect various aspects of a patient's life, including speech, swallowing, breathing and limb function."], ['These results support a critical role for early dietary influence on the brain vasculature across the lifespan, with consequences for the development of age-related cerebrovascular and neurodegenerative diseases.'], ['It contains recent discoveries in this novel field, focusing on advanced mitochondrial therapies to chronic and degenerative diseases, mitochondrial diseases, lifespan extension, mitohormesis, intracellular signaling, new pharmacological targets and natural therapies.', 'Likewise, other diseases in which mitochondrial dysfunction plays a very important role include neurodegenerative diseases, diabetes or cancer.', 'This is the case of type 2 diabetes or neurodegenerative diseases.', 'Parkinson s Disease (PD) is a very good example of this important mitochondrial component on neurodegenerative diseases.', 'Mitochondrial dysfunctions are the prime source of neurodegenerative diseases and neurodevelopmental disorders.', 'A common hallmark of several neurodegenerative diseases (Huntington s Disease, Alzheimer s Disease and Parkinson s Disease) is the impaired function or expression of PGC-1alpha, the master regulator of mitochondrial biogenesis.'], ['Leigh syndrome is an early onset, often fatal progressive neurodegenerative disorder caused by mutations in the mitochondrial or nuclear DNA.'], ['Altogether, 87 adult skeletons were examined for degenerative joint diseases.'], ['However, these cells have not been used before in a model with more extensive neurodegeneration.'], ['Our results demonstrate a critical role of thymidine metabolism in controlling human telomerase and telomere length, which may be therapeutically actionable in patients with fatal degenerative diseases.'], ["It has been proven effective not only to reduce weight and extend the lifespan in animal models, but also to regulate the development and progression of various neurological diseases such as epilepsy, cerebrovascular diseases (stroke), neurodegenerative disorders (Alzheimer's disease and Parkinson's disease) and autoimmune diseases (multiple sclerosis)."], ['Rugby players are subject to multiple impacts to their head and neck that could have adverse neurological effects and put them at increased risk of neurodegeneration.', 'These preliminary observations provide new insights in the domain, which should now be further investigated on larger cohorts and multicentric longitudinal studies, and further correlated to the likelihood of neurodegenerative diseases and risk factors.'], ["In future, neurodegenerative diseases will take over cancer's place and become the major cause of death in the world, especially in developed countries.", 'Advancements in the medical field and its facilities have led to an increase in the old age population, and thus contributing to the increase in number of people suffering from neurodegenerative diseases.', 'There is an urgent need for therapy that could be able to overcome the deficits of conventional therapy for neurodegenerative diseases.', 'Stem cells, the unspecialized cells with the properties of self-renewing and potency to differentiate into various cells types can become a potent therapeutic option for neurodegenerative diseases.', 'In this review, we discuss the various types of stem cells and their potential use in the treatment of neurodegenerative disease based on published preclinical and clinical studies.'], ['Taken together, these findings establish a close relationship between the formation of alpha-synuclein inclusions in nerve cells and neurodegeneration, accompanied by a shift in microglial cell morphology.'], ["Development of age-related neurodegenerative diseases, such as Alzheimer's disease and related dementias, is associated with pronounced sleep disruption."], ['Epithelial ovarian cancer (EOC) is a chronic and degenerative disease propelled by mutation in BRCA1/2 genes, familial history, smoking and polycystic ovary syndrome.'], ['Clinical interpretation of pulmonary function and exercise tests, however, has been complicated more recently by temporal changes in demographic characteristics (higher life expectancy), anthropometric attributes (increased obesity prevalence), and the surge of polypharmacy in a sedentary population with multiple chronic degenerative diseases.'], ['Defects triggered by >300 NPC1 variants found in the human population inhibit export of NPC1 protein from the endoplasmic reticulum (ER) and/or function in downstream LE/Ly, leading to cholesterol accumulation and onset of neurodegeneration in childhood.'], ['Although our findings underscore the importance of repair for degenerative mitral disease, larger studies with longer term follow-up are needed to reinforce this finding, particularly for younger patients.'], ['Our society is currently experiencing increased lifespan; one of the top causes for the high incidence of neurodegenerative disorders.', 'Many evidences support the protective role of phytochemicals in the prevention of neurodegenerative diseases, particularly (poly)phenols.', 'In this review, we described the use of cellular-based models of neurodegenerative diseases and the benefits of their use as potent tools in the search for bioactive molecules, particularly (poly)phenols.'], ['Infantile neuroaxonal dystrophy (INAD) is a fatal neurodegenerative disorder that typically begins within the first few years of life and leads to progressive impairment of movement and cognition.', 'Interestingly, mutations in PLA2G6 are also causative in two other related neurodegenerative diseases, atypical neuroaxonal dystrophy and Dystonia-parkinsonism.', 'Finally, we show that iPLA2-VIA mutants exhibit increased sensitivity to oxidative stress, progressive neurodegeneration and a severely reduced lifespan.', 'Altogether, these data demonstrate that Drosophila iPLA2-VIA mutants provide a useful model to study human PLA2G6-associated neurodegeneration.'], ['OA is a degenerative disease characterized by cartilage and synovium inflammation that can cause joint stiffness, swelling, pain, and loss of mobility.'], ['Candidate-gene methods were used to comprehensively analyze associations of novel uncommon variants in Caucasians (minor allele frequency~2.5%) located in band 2q22.3 with risks of coronary heart disease (CHD), heart failure (HF), stroke, diabetes, cancer, neurodegenerative diseases (ND), and mortality in the ARIC study, the Framingham Heart Study (N = 4,434), and the Health and Retirement Study (N = 9,676).', 'Meta-analysis of the results from these comprehensive analyses shows that the minor allele increases risks of death by about 50% (p = 4.6x10-9), CHD by 35% (p = 8.9x10-6), HF by 55% (p = 9.7x10-5), stroke by 25% (p = 4.0x10-2), and ND by 100% (p = 1.3x10-3).'], ['In addition to progressive neurodegeneration and high rates of cancer, AT patients have numerous symptoms that can be linked to chronic inflammation.'], ['Mucopolysaccharidosis type IIIC (MPS IIIC) is a lethal disorder, caused by mutations in the heparan-alpha-glucosaminide N-acetyltransferase (HGSNAT) gene and characterized by progressive neurological deterioration, with retinal degeneration as a prominent feature.', 'All patients were diagnosed with non-syndromic RP and did not exhibit neurological deterioration, or any phenotypic features consistent with MPS IIIC.'], ['Furthermore, thanks to new technologies, vaccines now have the potential to make an enormous contribution to the health of modern society by preventing and treating not only communicable diseases in all ages, but also noncommunicable diseases such as cancer and neurodegenerative disorders.'], ["Neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD) and amyotrophic lateral sclerosis (ALS), originate from a loss of neurons in the central nervous system (CNS) and are severely debilitating.", 'The incidence of neurodegenerative diseases increases with age, and they are expected to become more common due to extended life expectancy.', 'Prior studies have shown that microRNAs (miRNAs) are pathologically altered during the inexorable course of some neurodegenerative diseases, suggesting that miRNAs may be the contributing factor in neurodegeneration.', 'Here, we review what is known about the involvement of miRNAs in the pathogenesis of neurodegenerative diseases.', 'We focus in particular on dysregulation of miRNAs which leads to several neurodegenerative diseases from three aspects: miRNA-generating disorders, miRNA-targeting genes and epigenetic alterations.', 'Furthermore, recent evidences have shown that circulating miRNA expression levels are changed in patients with neurodegenerative diseases.', 'A discussion is included with a potential diagnostic biomarker and the possible future direction in exploring the nexus between miRNAs and various neurodegenerative diseases.'], ["Furthermore, aberrant, excessive, insufficient, or mistimed plasticity may represent the proximal pathogenic cause of neurodevelopmental and neurodegenerative disorders such as autism spectrum disorders or Alzheimer's disease."], ['In this review, we discuss recent published evidence that suggests that inflammation in the lung is an important connection between air pollution and chronic inflammatory diseases such as autoimmunity and neurodegeneration, and we highlight the critical role of metabolic stressors produced in the lung.'], ['Therefore understanding the molecular alterations responsible for neurodegeneration has become imperative in order to develop efficient strategies for the therapy.', "Mounting evidence suggests that the essential metal ion copper is intriguingly connected with the established molecular markers of Alzheimer's disease and that copper homeostasis is disturbed in affected individuals, leading to oxidative stress and neurodegeneration."], ["Alzheimer's disease (AD) is a neurodegenerative disorder that severely reduces lifespan."], ['Mesenchymal stem cells (MSCs) have shown a certain therapeutic potential in neurodegenerative diseases including AD due to their neuroinflammatory regulation and neuroprotective effects.'], ['Moreover, the microbiota has been linked with neurodevelopmental, neuropsychiatric, and neurodegenerative disorders.'], ["This association was mediated by higher neurodegeneration and higher white matter hyperintensities load but not by Alzheimer's disease (AD) biomarkers.", 'The hypertension-cognition association is mediated by neurodegeneration and leukoaraiosis.'], ['BACKGROUND CONTEXT: Multiple sclerosis (MS) is an autoimmune, neurodegenerative disease that can lead to significant functional disability.'], ["Alzheimer's disease (AD) is a disabling neurodegenerative disorder that leads to long-term functional and cognitive impairment and greatly reduces life expectancy."], ['In addition to identification of a number of genes whose roles in neurodegeneration were not previously known, our screen also yielded genes involved in chromatin regulation and nuclear/import export- pathways that were previously identified in the context of cell based or neurodevelopmental suppressor screens.', 'Our identification SF2/SRSF1 as a potent suppressor of both neuronal and glial TDP-43 toxicity also provides a convergence with C9orf72 expansion repeat mediated neurodegeneration, where this gene also acts as a downstream mediator.'], ['However, despite nutritional correction, occasional rapid neurological deterioration may develop after PEG placement.', 'We have hypothesized that this decline can be a result of exteroceptive stress during PEG placement and promote neurodegeneration in ALS patients.', 'The aim of the study was comparing different PEG placement protocols of anesthesia (local anesthesia or local anesthesia plus intravenous sedation) in ALS from perspectives of stress load and neurological deterioration profile.', 'Routine biochemical indices, neurodegeneration and stress markers were measured.'], ["WW domain-containing oxidoreductase (WWOX) is known as one of the risk factors for Alzheimer's disease (AD), a neurodegenerative disease."], ["Missense mutations in Valosin-Containing Protein (VCP) are linked to diverse degenerative diseases including IBMPFD, amyotrophic lateral sclerosis (ALS), muscular dystrophy and Parkinson's disease."], ['BACKGROUND: Amyotrophic lateral sclerosis (ALS) is an adult-onset, fatal neurodegenerative disease characterized by progressive loss of upper and lower motor neurons.'], ["The results have implications for developing assessment tools and are discussed within the current theories of age of acquisition and the impact of the neurodegenerative loss of memory in Alzheimer's disease on lexicosemantic processing."], ['Expansions of trinucleotide or hexanucleotide repeats lead to several neurodegenerative disorders, including Huntington disease [caused by expanded CAG repeats (CAGr) in the HTT gene], and amyotrophic lateral sclerosis [ALS, possibly caused by expanded GGGGCC repeats (G4C2r) in the C9ORF72 gene], of which the molecular mechanisms remain unclear.', 'Here, we demonstrated that lowering the Drosophila homologue of tau protein (dtau) significantly rescued in vivo neurodegeneration, motor performance impairments, and the shortened life-span in Drosophila expressing expanded CAGr or expanded G4C2r.', 'Expression of human tau (htau4R) restored the disease-related phenotypes that had been mitigated by the loss of dtau, suggesting an evolutionarily-conserved role of tau in neurodegeneration.', 'Taken together, our results reveal a novel mechanism by which expanded G4C2r causes neurodegeneration via an evolutionarily-conserved mechanism.'], ["Based on reports on human subjects and animal models this review will explore the evidence on how developmental exposure of the known environmental pollutant, lead (Pb), can induce changes in the DNA methylation of genes which later can induce development of neurodegenerative disorders like Alzheimer's disease (AD)."], ['The neurodegenerative disorder spinocerebellar ataxia type 7 (SCA7) is caused by a polyglutamine (polyQ) expansion in the ataxin-7 protein, categorizing SCA7 as one member of a large class of heritable neurodegenerative proteinopathies.', 'When we compared SCA7-D266N mice with SCA7 mice lacking the D266N mutation, we found that SCA7-D266N mice exhibited improved motor performance, reduced neurodegeneration and substantial lifespan extension.'], ['We found that inhibition of Ctr1C expression by RNAi in Abeta-expressing flies significantly reduced copper accumulation in the brains of the flies as well as ameliorating neurodegeneration, enhancing climbing ability, and prolonging lifespan.'], ['Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease characterized by progressive degeneration of motor neurons which brings to muscular atrophy, paralysis and death in 3-5 years from starting symptoms.'], ['Blockade of AT(1) receptors offers a novel and safe therapeutic approach for the treatment of illnesses of increasing prevalence and socioeconomic impact, such as mood disorders and neurodegenerative diseases of the brain.'], ['To identify genes required for maintaining neuronal viability, we screened our collection of Drosophila temperature-sensitive paralytic mutants for those exhibiting shortened lifespan and neurodegeneration.', 'Mutations causing Tpi deficiency in humans are also characterized by progressive neurological dysfunction, neurodegeneration, and early death.'], ["There is emerging evidence that impaired transport is not only causative for a range of motor disorders, but possibly also for Alzheimer's disease (AD) and related neurodegenerative disorders."], ["Although multiple system atrophy (MSA) is a neurodegenerative disorder leading to progressive disability and decreased life expectancy, little is known about patients' own evaluation of their illness and factors associated with poor health-related quality of life (Hr-QoL)."], ["Apoptosis or programmed cell death is considered to be involved in neurodegenerative disorders including Alzheimer's disease (AD)."], ['An unexpected consequence, however, has been an increase in the number of age-related diseases and, in particular, neurodegenerative diseases.', 'A powerful method that can be used to understand the basic mechanisms underlying neurodegenerative diseases is to generate animal models based on manipulating the expression of single genes that are disease causative.', 'This approach has been facilitated by the fact that many neurodegenerative diseases are inherited as autosomal dominant traits such that expression of the mutant gene in a model organism might be expected to recapitulate the disease.', 'During the past few years, the fruit fly, Drosophila melanogaster, has emerged as a powerful tool to model human neurodegenerative diseases.', 'Here, we describe the various approaches utilized to create fly models of human neurodegenerative disease, and how they can aid in our understanding of disease pathogenesis and facilitate drug discovery and testing.'], ['Pharmacological activation of the heat shock response may therefore be a successful therapeutic approach to treating ALS, and possibly other neurodegenerative diseases.'], ['Our findings provide new insights about the neurobiology of VPS13B and highlight previously unreported brain phenotypes while defining Cohen syndrome as a likely new entity of non-progressive infantile neurodegeneration.'], ['BACKGROUND: As people with HIV (PWH) age, it remains unclear whether they are at higher risk for age-related neurodegenerative disorders, e.g., Alzheimer disease (AD), and if so, how to differentiate HIV-associated neurocognitive impairment from AD.'], ["OBJECTIVES: Alzheimer's disease (AD) is a neurodegenerative disorder characterized by the presence of aggregated amyloid-beta (Abeta) peptides."], ['Dynactin-1 (DCTN1)-related Parkinson-plus disorder (Perry syndrome) is an autosomal dominant neurodegenerative disorder characterised by levodopa-resistant parkinsonism, weight loss, mood change and central hypoventilation.', 'Its rarity and clinical overlap with other neurodegenerative diseases increase the risk of delayed or incorrect diagnosis.'], ['Niemann-Pick disease, type C1 (NPC1) is a neurodegenerative disorder with limited treatment options.'], ['The aim of this paper is to gain better understanding of the ocular manifestations of multiple system atrophy (MSA), a neurodegenerative disorder rarely studied in terms of its ophthalmologic features.'], ['Neurodegenerative diseases are going to increase as the life expectancy is getting longer.', "The management of neurodegenerative diseases such as Alzheimer's disease (AD) and other dementias, Parkinson's disease (PD) and PD related disorders, motor neuron diseases (MND), Huntington's disease (HD), spinocerebellar ataxia (SCA), and spinal muscular atrophy (SMA), is mainly addressed to motor and cognitive impairment, with special care to vital functions as breathing and feeding.", 'Given the relevance of pain in neurodegenerative disorders, the comprehensive understanding of mechanisms and predisposing factors, the application and validation of specific scales, and new specific therapeutic trials are needed.'], ['Most existing mouse models of tauopathy overexpress mutant tau at levels that do not occur in human neurodegenerative disease, whereas Tau35 transgene expression is equivalent to less than 10% of that of endogenous mouse tau.', 'Importantly, we found that sodium 4-phenylbutyrate (Buphenyl ), a drug used to treat urea cycle disorders and currently in clinical trials for a range of neurodegenerative diseases, reverses the observed abnormalities in tau and autophagy, behavioural deficits, and loss of synapsin 1 in Tau35 mice.'], ['We found several other examples of derived alleles at other human loci that protect against age-related cognitive deterioration arising from neurodegenerative disease or cerebrovascular insufficiency.'], ["MD's encompass a heterogeneous group of degenerative disorders often characterized by progressive muscle weakness and fragility."], ['Neurodegenerative diseases are characterized by a progressive deterioration of brain function, with a consequent significant decline in the quality of life of patients and their families.', 'This review focuses on the correlation between peripheral inflammatory diseases and neurodegeneration, in particular on the relationship between gastrointestinal disorders and Parkinson's disease, especially through the so called gut-brain axis.'], ['Microtubule-associated protein tau mutations cause a group of neurodegenerative diseases termed tauopathies.', 'These results suggest that LRRK2 and tau do not interact to exacerbate behavioral, biochemical or pathological abnormalities in neurodegeneration and that LRRK2 and tau exert their pathogenic effects through independent mechanisms.'], ['Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder characterized by motoneuron degeneration, resulting in muscle paralysis and death, typically within 1-5 years of diagnosis.'], ['These observations led to the discovery of compounds that either prolong the lifespan of endocannabinoids or tone down their action for the potential future treatment of pain, affective and neurodegenerative disorders, gastrointestinal inflammation, obesity and metabolic dysfunctions, cardiovascular conditions and liver diseases.'], ['Amyotrophic lateral sclerosis (ALS) is an adult-onset neurodegenerative disease characterized by selective loss of motor neurons and progressive muscle wasting.'], ["Parkinson's disease (PD) is a neurodegenerative disorder with progressive impairment in motor and cognitive functioning."], ['METHODS: The database of patients who had undergone GBP by one general surgeon at a university hospital between September 1981 and January 2000 was queried as to weight, body mass index (BMI), pre- and postoperative diabetes, hypertension, and other comorbidities, including sleep apnea, hypoventilation, gastroesophageal reflux, degenerative joint disease, urinary incontinence, venous stasis, and pseudotumor cerebri.'], ['A great amount of experimental and clinical evidence indicated that AD is a complex disorder characterized by widespread neurodegeneration of the CNS, with major involvement of the cholinergic system, causing progressive cognitive decline and dementia.'], ["Alzheimer's disease is a neurodegenerative disorder whose etiology continues to be discussed, to the point that there are different hypotheses that seek to clarify it, in addition to the fact that, given its multifactorial nature, there are different risk factors associated with its development."], ['Amyotrophic Lateral Sclerosis is a devastating neurodegenerative disease causing rapid degeneration of motor neurons and usually leading to death by respiratory failure.'], ['SUMMARY: MSA is a rapidly progressive neurodegenerative disease characterized by a combination of autonomic failure and motor symptoms.', 'MSA is often misdiagnosed as the initial presentation mimics other neurodegenerative disorders.'], ["Emerging data support that plant food based isoflavones have ameliorating effects on a variety of neurodegenerative diseases including Parkinson's disease (PD)."], ["Neurodegenerative diseases such as Parkinson's disease (PD)have increasing incidence, due to lifespan expansion."], ['PURPOSE: Juvenile neuronal ceroid lipofuscinosis (CLN3 disease) is the most common neurodegenerative disorder in childhood with survival until young adult age.'], ["The neurotropic and neuro-invasive properties of HSV are responsible for neurodegenerative illnesses, such as Alzheimer's disease."], ['BACKGROUND: Progressive supranuclear palsy is a neurodegenerative disorder characterized by high functional disability and rapidly progressive dependency.'], ['Disrupted insulin signaling pathways are evident in AD patients and it is understood that type 2 diabetes can increase the risk of developing AD, suggesting a possible link between metabolic disorders and neurodegeneration.'], ['CEMTDD contains about 621 herbs, 4, 060 compounds, 2, 163 targets and 210 diseases, among which most of herbs can be applied into gerontology therapy including inflammation, cardiovascular disease and neurodegenerative disease.'], ['The recent medical literature highlights the lack of new drugs able to prevent or treat neurodegenerative diseases such as Alzheimer disease or Parkinson disease.'], ['The continuously prolonged human lifespan is accompanied by increase in neurodegenerative diseases incidence, calling for the development of inexpensive blood-based diagnostics.', 'This novel workflow allows deep multi-level inspection of RNA-Seq datasets and provides a comprehensive new resource for understanding disease transcriptome modifications in PD and other neurodegenerative diseases.'], ['2-hydroxypropyl-beta-cyclodextrin (HPbetaCD) is a promising experimental therapy for Niemann-Pick type C disease that improved intracellular cholesterol transport, substantially reduced neurodegeneration and hepatic disease, and increased lifespan in npc1 mice.'], ['They also offer a starting-point for novel means of delaying neurodegenerative disease, and/or for strengthening memory function and intellectual capabilities.Finally, creatine biosynthesis has been postulated as a major effector of homocysteine concentration in the plasma, which has been identified as an independent graded risk factor for atherosclerotic disease.'], ['Surgical intervention is limited to specific indications, including spinal instability, progressive neurologic deterioration from bony collapse and compression, intractable pain, and failure of conservative means of treatment.'], ['The strong correlation between pretreatment motor status and treatment outcome underscores the importance of immediate treatment before further neurologic deterioration and before the damage to the spinal cord becomes permanent.', 'In addition, paraplegic patients or severely paraparetic patients with recent neurologic deterioration should be treated with immediate surgical decompression if they are judged reasonably able to tolerate the surgery.'], ["Pre-existing or enhanced cognitive abilities influence symptom onset and severity in neurodegenerative diseases, which improve an individual's ability to deal with neurodegeneration.", 'This process is named cognitive reserve (CR), and it has acquired high visibility in the field of neurodegeneration.', 'However, the investigation of CR has been neglected in the context of cerebellar neurodegenerative disorders.', 'The present study assessed CR and its impact on cognitive abilities in spinocerebellar ataxia type 2 (SCA2), which is a rare cerebellar neurodegenerative disease.'], ["Alzheimer's disease (AD) is the most common neurodegenerative dementia."], ['Based on current findings concerning the parietal lobe in both pathologies, we hypothesize that the increased activity of the parietal lobe in people with VI may diminish the neurodegeneration of this brain region in those who are visually impaired by oculardiseases.'], ["Alzheimer's disease (AD) represents the most common type of neurodegenerative dementia and is characterized by extracellular amyloid-beta (Abeta) deposition, pathologic intracellular tau protein tangles, and neuronal loss."], ['OBJECTIVE: There are minimal data directly comparing plasma neurofilament light (NfL) and glial fibrillary acidic protein (GFAP) in aging and neurodegenerative disease research.', 'Biomarkers reflecting astroglial pathophysiology may capture complex dynamics of aging and neurodegenerative disease.'], ['Here, we will collect evidence showing the value of action observation treatment (AOT) in the recovery of impaired motor abilities for a vast number of clinical conditions, spanning from traumatological patients to brain injuries and neurodegenerative diseases.'], ['Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease.', 'Interference with one class of epigenetic enzymes, histone deacetylases, has been shown to affect neurodegeneration in many preclinical models.'], ['Emerging evidence suggest that dimethylbiguanide (metformin), a first-line drug for type 2 diabetes mellitus, could be neuroprotective in a range of brain pathologies, which include neurodegenerative diseases and brain injury.', 'In this brief review, the findings associated with the effects of metformin in attenuating neurodegenerative diseases are discussed, focusing on HD-associated pathology and the potential underlying mechanisms highlighted by these studies.'], ['The early adulthood emergence of these deficits suggests that they represent aberrant network patterning during development, an early neurodegeneration prodrome, or both.'], ['Brains from these mice were also analysed for signs of neurodegeneration and striatal and cortical volume sizes compared using anatomic 16.4T magnetic resonance imaging (MRI) brain scans.'], ['Interestingly, nerve growth factor (NGF), a neurotrophic factor found in ASC-CM, played a significant role in the protection of neurodegeneration inSOD1(G93A) mouse.'], ['Complete functional complementation demonstrated that the development of severe and rapid neurodegeneration in these mice is independent of the hematopoietic lineage and has clinical implications for treatment of osteopetrosis.'], ['In the period after the discovery of antipsychotics significant changes in morbidity occurred with the prevalence of chronic degenerative diseases, primarily diabetes, hypertension and dyslipidemia.'], ["However, this is accompanied by an increased probability of suffering from neurodegenerative diseases like Alzheimer's disease or Parkinson's disease.", 'Many studies indicate that a variety of environmental factors contribute to the initiation and promotion of neurodegenerative diseases.'], ['For example, C. elegans has provided crucial insights into fundamental biologic processes, such as cell death and cell fate determinations, as well as pathologic processes such as neurodegeneration and microbial susceptibility.'], ['Amyotrophic lateral sclerosis (ALS) is the most common neurodegenerative disease of the motor system.'], ['Transgenic (tg) mice expressing human mutant alpha-Syn or SOD1 develop profound fatal neurologic disease characterized by progressive motor deficits, paralysis, and neurodegeneration.'], ['Silencing of dUbqln in the central nervous system led to age-dependent neurodegeneration and shortened lifespan.'], ["Transplantation of neural stem cells or their derivatives into a host brain and the proliferation and differentiation of endogenous stem cells by pharmacological manipulations are potential treatments for many neurodegenerative diseases and brain injuries, such as Parkinson's disease, brain ischemia and spinal cord injury."], ['Results suggest that the palliative care model has much to offer individuals with degenerative neuromuscular conditions and their families, but it is not yet recognized as an important part of care for young people with MD.'], ['Recent mortality declines have been concentrated at the older ages and in the degenerative diseases.'], ["Neurodegenerative disorders (NDDs) are complex, multifactorial disorders with significant social and economic impact in today's society."], ["BACKGROUND: Parkinson disease (PD) and Alzheimer's disease (AD) are progressive neurodegenerative disorders characterized by loss of selective neurons in discreet part of the brain.", 'Blockade of the angiotensin converting enzyme or ATI receptors provides protection in animal models of neurodegenerative diseases.', 'This was followed by fecundity, larva motility, negative geotaxis assay (climbing) and lifespan as a measure of neurodegeneration.', 'Conclusion: Findings from this study confirmed the neuroprotective action of captopril in genetic or familial forms of neurodegeneration.'], ['Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS) leading to demyelination and neurodegeneration.'], ["Traumatic brain injury (TBI) is a predisposing factor for many neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS), Alzheimer's disease (AD), Parkinson's disease (PD), and chronic traumatic encephalopathy (CTE).", 'Although defects in nucleocytoplasmic transport (NCT) is reported ALS and other neurodegenerative diseases, whether defects in NCT occur in TBI remains unknown.'], ['Future research incorporating tau and other markers of neurodegeneration is needed to clarify the sequence of events that lead to this early, subclinical memory decline.'], ['They subsequently received surgery either for neurological deterioration, or deformity correction in later life.', 'Some 16 patients (66.7%) suffered from late neurological deterioration at a mean of 26 years (8 to 49) after the initial drug treatment.', 'The causes of neurological deterioration were healed disease in nine patients (56.2%), re-activation in six patients (37.5%) and adjacent level spinal stenosis in one patient (6.3%).', 'Eight patients without neurological deterioration received surgery to correct the kyphosis.', 'Three patients who were clinically quiescent with no neurological deterioration were found to have active TB of the spine.', 'Solid fusion was achieved in all cases and no patient suffered from neurological deterioration after 42 years of follow-up.'], ["Alzheimer's disease (AD) is an age-related neurodegenerative disease, of which beta-amyloid (Abeta) induced toxicity was suggested as a main cause."], ["Huntington's disease is a neurodegenerative disorder caused by toxic insertions of polyglutamine residues in the Huntingtin protein and characterized by progressive deterioration of cognitive and motor functions.", 'We demonstrated that overexpression of the human glucose transporter in neurons ameliorated significantly the status of HD flies by increasing their lifespan, reducing their locomotor deficits and rescuing eye neurodegeneration.', 'Overexpression of glucose-6-phosphate dehydrogenase (G6PD), the key enzyme of the PPP, extended significantly the lifespan of HD flies and rescued eye neurodegeneration.'], ["BACKGROUND: Parkinson's disease (PD) is the second most common degenerative disorder of the central nervous system that impairs motor skills and cognitive function.", 'However, the lengthy time frame for the progression of neurodegeneration in PD increases both the time and cost of examining potential therapeutic compounds in mammalian models.'], ['METHODS AND RESULTS: From May 1998 to January 2012, 72 patients underwent elective reconstruction of the ascending aorta for degenerative disease at the department of Cardiothoracic Surgery of the Jessa Hospital, Hasselt, Belgium.'], ['The fragile X-associated tremor/ataxia syndrome (FXTAS) is an adult-onset neurodegenerative disorder caused by CGG trinucleotide repeat expansions in the fragile X mental retardation 1 (FMR1) gene.'], ['OBJECTIVE: Multiple system atrophy (MSA) and progressive supranuclear palsy (PSP), known as atypical parkinsonian syndromes (APS), are neurodegenerative disorders with severe disability and decreased life expectancy.'], ['The group comprised 159 patients undergoing decompression for degenerative spinal disorders who had been participants in a randomised controlled trial of post-operative rehabilitation that had shown no between-group differences at 2 years.'], ['Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease of motor neurons (MNs).'], ['Machado-Joseph disease [MJD, also spinocerebellar ataxia type 3 (SCA3)] and familial amyloid polyneuropathy type I (FAP-I or ATTR V30M) are neurodegenerative disorders, inherited in an autosomal dominant fashion, which have a high prevalence in Portugal, probably due to a founder effect.'], ['More developed countries and regions tend to approximate the wealth model where chronic and degenerative diseases dominate.', 'Still, while life expectations are shorter in countries and regions with lower levels of development, some elderly are afflicted by chronic and degenerative diseases.'], ['Using this inducible expression system, we have tested which transgenes robustly up- or downregulate autophagy and have validated these tools using Lc3-II blots and puncta analysis and disease rescue in a zebrafish model of neurodegeneration.', 'These tools allow the temporal control of autophagy via the administration of tamoxifen and spatial control via tissue or cell-specific ERT2-Gal4 driver lines and will enable the investigation of how cell- or tissue-specific changes in autophagic flux affect processes such as aging, inflammation and neurodegeneration in vivo.Abbreviations: ANOVA: analysis of variance; Atg: autophagy related; Bcl2l11/Bim: BCL2 like 11; d.p.f.'], ['Neurodegenerative diseases are a heterogeneous group of disorders among aging populations worldwide characterized by the progressive degeneration of the structure and function of brain cells and the nervous system.', "Alzheimer's disease and Parkinson's disease are common neurodegenerative diseases (NDs).", 'The pathogenesis is multifactorial, and both neurodegenerative disorders have complex etiology.', 'Ample evidence has implicated that oxidative stress and inflammation contribute to the pathology of neurodegeneration in AD and PD.'], ['These findings suggest the joint role of cerebral small vessel disease and neurodegeneration in the epsilon4-cognition relationship.'], ['As human life expectancy increases, there is an increased prevalence of neurodegenerative disorders and dementia.', 'However, conventional neuroimaging often fails to provide enough diagnostic findings in patients with neurodegenerative disorders.', 'As many neurodegenerative disorders are associated with accelerated iron deposition and/or microhemorrhages in different parts of the brain, SWI can be applied to detect these diagnostic clues.', 'Being familiar with SWI findings in neurodegenerative disorders is critical for an accurate diagnosis.', 'In this paper, the authors review the technical parameters of SWI, physiologic, and pathologic iron deposition in the brain, and the role of SWI in the evaluation of neurodegenerative disorders in daily practice.'], ['Therefore, assessing objective and subjective sleep quality could be clinically useful, as they are both related to important domains of cognition frequently impacted in HIV-associated neurocognitive disorders as well as neurodegenerative disorders associated with aging.'], ['Since Caenorhabditis elegans was first introduced as a genetic model organism by Sydney Brenner, researchers studying it have made significant contributions in numerous fields including investigations of the pathophysiology of neurodegenerative diseases.', "Here we review studies that have attempted to establish genetic models of specific human neurodegenerative diseases (ALS, Alzheimer's Disease, Parkinson's Disease, Huntington's Disease) in C. elegans and what they have contributed to understanding the molecular and genetic underpinnings of each disease."], ['Amyotrophic Lateral Sclerosis (ALS), is a fatal neurodegenerative disorder, with TDP-43 inclusions as a major pathological hallmark.'], ['Moreover, life expectancy is increasing especially in developed countries, however, cases of neurodegenerative diseases have grown in the older members of the population.'], ["An increase in the life expectancy during the last decades in most world countries has resulted in the growing number of people suffering from neurodegenerative disorders, including Alzheimer's disease, Parkinson's disease, frontotemporal dementia, and others.", 'Familial forms of neurodegenerative diseases account for 5-10% of all cases and are caused by mutations in specific genes often resulting in pathological protein deposition.', 'The risk factors for neurodegeneration include trauma, lifestyle, and allelic variants of disease-associated genes with incomplete penetrance.', 'The involvement of adaptive immunity mechanisms (antigen presentation, T cell response, antibody production) in the development of neurodegenerative diseases remains unclear and requires further research, including more detailed studies of the role of identified HLA class II genetic variants.'], ['Persons younger than 85 years with mild cognitive impairment, amyloidosis, and neurodegeneration have lifetime risks of AD dementia greater than 50%.'], ["PC as a specific discipline, as well as a treatment strategy for long-term neurological conditions such as Parkinson's disease (PD), is relatively new, but very important as neurodegenerative disorders in the United Kingdom alone affects approximately 10 million people and there are over 130,000 people with PD."], ['As well known, the increase in life expectancy and the better physical condition of people in western countries will lead in the next 20 years to a dramatic development of neurodegenerative diseases, especially of dementia that could be considered one of the most important problems in clinical, social and economic fields for the future.'], ['Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease caused by loss of motor neurons.'], ['Late-onset, sporadic Alzheimer disease (AD) is a common and lethal neurodegenerative disorder and many germline inherited variants have been found to influence the risk of developing AD.'], ['Aim: Amyotrophic lateral sclerosis (ALS) is a chronic, neurodegenerative disease, which leads to development of malnutrition.'], ['DNA damage repair is implicated in neurodegenerative diseases; however, the relative contributions of various DNA repair systems to the pathology of these diseases have not been investigated systematically.'], ['Taken together, these observations indicate that the neuronal expression of AK1 is induced by Abeta(42) to increase abnormal tau phosphorylation via AMPK-GSK3beta and contributes to tau-mediated neurodegeneration, providing a new upstream modulator of GSK3beta in the pathologic phosphorylation of tau.'], ['Importantly, coexpression of human parkin in LRRK2 G2019S-expressing flies provides significant protection against DA neurodegeneration that occurs with age or in response to rotenone.'], ["Few people would have agreed at the time, but this statement turned out to be prophetic, and this process of 'self-eating' rapidly exploded as a research field, as scientists discovered connections to cancer, neurodegeneration and even lifespan extension."], ['Because most deaths in the United States result from chronic progressive illnesses (eg, cancer and cardiovascular, cerebrovascular, pulmonary, and neurodegenerative diseases) that affect older individuals, discussion focuses on the provisions of the Medicare Hospice Benefit, which has become an important entitlement in efforts to improve care of the dying in this country.'], ['However, neurometabolic and degenerative diseases, as well as certain developmental brain malformations such as anencephaly, can also cause this condition.'], ['Not surprisingly, impairment of mitochondrial homeostasis is tightly associated with the development and progression of a broad spectrum of human pathologies, including neurodegenerative disorders.', 'Here, we survey the intricate interplay between mitophagy and neuroinflammation, highlighting that mitophagy can be a focal point for therapeutic interventions to tackle neurodegeneration.'], ["Here we show that SIRT3 is neuroprotective in Huntington's disease (HD), a motor neurodegenerative disorder caused by an abnormal expansion of polyglutamines in the huntingtin protein (HTT).", 'Notably, SIRT3 fly-ortholog dSirt2 overexpression in HD flies ameliorated neurodegeneration and extended lifespan.'], ['Krabbe disease (KD) is caused by a deficiency of galactosylceramidase (GALC), which induces demyelination and neurodegeneration due to accumulation of cytotoxic psychosine.'], ['INTRODUCTION: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder with no known cure and with an average life expectancy of 3-5 years post diagnosis.'], ['Mutations in PLA2G6 (PARK14) cause neurodegenerative disorders in humans, including autosomal recessive neuroaxonal dystrophy and early-onset parkinsonism.', 'We show that loss of iPLA2-VIA, the fly homolog of PLA2G6, reduces lifespan, impairs synaptic transmission, and causes neurodegeneration.', 'Reducing ceramides with drugs, including myriocin or desipramine, alleviates lysosomal stress and suppresses neurodegeneration.'], ['Neurodegenerative diseases are relentlessly progressive, severely impacting affected patients, families and society as a whole.', 'Wasp and bee venoms and their components are potential means of managing or reducing these effects and provide new alternatives for the control of neurodegenerative diseases.', "In this respect, the present study reviews our current understanding of the mechanisms of action and future prospects regarding the use of new drugs derived from wasp and bee venom in the treatment of major neurodegenerative disorders, including Alzheimer's Disease, Parkinson's Disease, Epilepsy, Multiple Sclerosis and Amyotrophic Lateral Sclerosis."], ['Importantly, even after neurodegeneration and onset of motor dysfunction, removal of cytoplasmic TDP-43 and the concomitant return of nuclear TDP-43 led to neuron preservation, muscle re-innervation and functional recovery.'], ['Inherited mutations in genes related to BER can give rise to disorders involving cancer, immunodeficiency and neurodegeneration.'], ['Recent reports suggest that general anesthetics may be such a factor and may contribute to the development and exacerbation of this neurodegenerative disorder.'], ["Parkinson's disease (PD) is a neurodegenerative disorder characterized by motor and non-motor symptoms and the selective loss of dopaminergic neurons."], ['Transmissible spongiform encephalopathies (TSEs), also known as prion diseases, describe a group of fatal neurodegenerative disorders affecting both humans and animals.', 'In the past 10 years, antibody-based immunotherapy has been considered for other neurodegenerative disorders associated with protein misfolding and, therefore, might also be an effective approach to prevention or treatment of prion disease.'], ['This review addresses the hypothesis that changes in lipid rafts induced by alterations in their ganglioside and/or cholesterol content or the interaction of mutant proteins with them provide the keys to understanding the onset of neurodegeneration that can lead to dementia.'], ["Huntington's disease is a devastating neurodegenerative condition associated with the formation of intraneuronal aggregates by mutant huntingtin.", "Aggregate formation is a property shared by the nine related diseases caused by polyglutamine codon expansion mutations and also by other neurodegenerative conditions like Parkinsons's disease."], ["This exciting data, if confirmed in other long term clinical trials, may herald a new approach for the treatment of this degenerative disease, since more recent studies indicate that Parkinson's disease may eventually turn out to be a neurotoxic event (see Snyder and D'Amato, 1986, for review)."], ["Alzheimer's Disease (AD) is a neurodegenerative disease that has a higher risk in adults with metabolic diseases."], ['Alteration of the levels, localization or post-translational processing of the microtubule associated protein Tau is associated with many neurodegenerative disorders.', 'Here we develop adult-onset models for human Tau (hTau) toxicity in Drosophila that enable age-dependent quantitative measurement of central nervous system synapse loss and axonal degeneration, in addition to effects upon lifespan, to facilitate evaluation of factors that may contribute to Tau-dependent neurodegeneration.', 'Our data establish a molecular and subcellular mechanism necessary and sufficient for the depletion of retromer activity to exacerbate Tau-dependent neurodegeneration.'], ['Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease of motor neurons leading to death within 3 years and without a curative treatment.'], ['Neuropathological examination showed classic changes of lower motor neuron neurodegeneration, in line with those reported in the single molecularly confirmed case published so far, and with findings in rare cases reported prior to the discovery of the gene defect.', 'The presence of significant hemosiderin deposits in the spinal cord and sensory nerve roots with associated tissue and axonal damage provide a plausible explanation for the unexpected sensory symptomatology in this mild lower motor neurodegeneration.'], ['The sequence of cellular events that cause neurodegeneration and ultimately death is poorly understood.'], ['No papers reporting on other lung diseases, neurodegenerative disease or cirrhosis were found.'], ['Developmental and degenerative abnormalities affecting the substructures of the spine can result in compression of the spinal cord and associated neural elements.'], ["Alzheimer's disease (AD) is a progressive neurodegenerative disease increasing in frequency as life expectancy of the world's population increases."], ["Alzheimer's (AD) and Parkinson's (PD) diseases are neurodegenerative diseases presently without effective drug treatments."], ['Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by the progressive loss of motor neurons in the brain and spinal cord.'], ['Amyotrophic lateral sclerosis is a relentless and devastating adult-onset neurodegenerative disease with no known cure.'], ['Among the burgeoning middle classes in some of these countries there are evidences of escalation of degenerative diseases such as diabetes and coronary heart disease.'], ['Neurodegenerative diseases affect millions of people worldwide.', 'The likelihood of developing a neurodegenerative disease rises dramatically as life expectancy increases.', 'Although it has drawn significant attention, there is still a lack of proper effective treatments for neurodegenerative disease because the mechanisms of its development and progression are largely unknown.', 'Increasing evidence suggests that EVs are involved in the pathogenesis of neurodegenerative disorders.', 'In this review, we summarize the recent findings of EVs in neurodegenerative diseases and bring up the limitations in the field.'], ['Mitochondria contain their own DNA (mtDNA) and mutations in mtDNA cause mitochondrial diseases with severe symptoms, such as neurodegeneration and heart disease.'], ["Parkinson's disease (PD) is an acute and progressive neurodegenerative disorder, and diagnosis of the disease at its earliest stage is of paramount importance to improve the life expectancy of patients."], ['Late adulthood and the transition into the later stage of life occasionally leads to neurodegenerative diseases that selectively affect different types of neurons and brain regions, producing motor dysfunctions, cognitive impairment, and psychiatric disorders that are progressive, irreversible, without remission periods, and incurable.', "Huntington's disease (HD) is a common neurodegenerative disorder."], ['Neurodegenerative diseases are linked to a systemic enzyme resistance of toxic aggregated molecules and their pathological consequences.', 'Our results may provide the basis for a new preclinical perspective on therapeutic research in human neurodegenerative diseases.'], ['Mice lacking Ndufs4, encoding NADH: ubiquinone oxidoreductase iron-sulfur protein 4 (NDUFS4) recapitulates the main findings of complex I (cI)-related LS, including severe multisystemic cI deficiency and progressive neurodegeneration.'], ["Using appropriate models of Huntington's disease (HD) is key to finding the molecular mechanisms that contribute to neurodegeneration.", 'Transgenic flies engineered to overexpress the human mutant HTT gene display protein aggregation, neurodegeneration, behavioral deficits and a reduced lifespan.'], ['Clinical trials, observational studies and meta-analysis have demonstrated an antiageing effect of MD accompanied by a reduced risk of age-related pathologies, such as cardiovascular, metabolic and neurodegenerative diseases, as well as cancer.', 'In particular, a new class of proteins called sirtuins have gained the attention of the scientific community because of their antiageing effects, their ability to protect from cardiovascular, metabolic, neurodegenerative diseases, cancer and to extend lifespan in lower organisms as well as in mammals.'], ['Apart from pain, hypercalcemia, and pathologic fracture, progressive tumor can result in neurologic deterioration caused by spinal cord compression or cauda equina involvement.'], ['In developed countries, increased life expectancy is accompanied by an increased prevalence of age-related disorders like cancer and neurodegenerative diseases.', 'Albeit the molecular mechanisms behind the clinically, pathologically and etiologically heterogeneous forms of neurodegeneration are often unclear, impairment of mitochondrial fusion-fission and dynamics emerged in recent years as a feature of neuronal dysfunction and death, pinpointing the need for animal models to investigate the relationship between mitochondrial shape and neurodegeneration.', 'While research on mammalian models is slowed down by the complexity of the organisms and their genomes, the long latency of the symptoms and by the difficulty to generate and analyze large cohorts, the lower metazoan Drosophila melanogaster overcomes these problems, proving to be a suitable model to study neurodegenerative diseases and mitochondria-shaping proteins.', 'Here we will summarize our current knowledge on the link between mitochondrial shape and models of neurodegeneration in the fruitfly.', "This article is part of a Special Issue entitled 'Mitochondrial function and dysfunction in neurodegeneration'."], ['Pathophysiological consequences of improper autophagy give rise to a variety of age-related human diseases such as cancer and neurodegeneration.'], ['The other 16 cases postoperatively showed neurological deterioration (36%), which was transient in 6 but with only minor improvement in 10.'], ['As human life expectancy increases, the incidence of neurodegenerative diseases in older adults has increased in parallel.'], ['These findings highlight the importance of considering sex in neuroimaging studies of aging and neurodegeneration.'], ['In this review, we discuss the role of CMA in combatting oxidative stress during the development of different conditions, such as aging, neurodegeneration, liver diseases, infections, pulmonary disorders, and cancers.'], ["Aging is an inevitable process characterized with progressive loss of physiological integrity and increased susceptibility to cancer, diabetes, cardiovascular, and neurodegenerative diseases; regarding the last, aging is the primary risk factor for Alzheimer's disease (AD), the most common cause of dementia."], ['A better understanding of the pathological mechanisms that drive neurodegeneration in people living with multiple sclerosis (MS) is needed to design effective therapies to treat and/or prevent disease progression.', 'We propose that CNS-intrinsic inflammation and re-modelling of the sub-arachnoid space of the leptomeninges sets the stage for neurodegeneration from the earliest stages of MS.', 'Here we review pathological correlates of MS disease progression, highlight emerging mouse models that mimic key progressive changes in MS, and provide new perspectives on therapeutic approaches to protect against MS-associated neurodegeneration.'], ["Huntington's disease (HD) is a neurodegenerative disorder caused by an expanded polyglutamine tract in the huntingtin (HTT) protein."], ['Human tauopathies represent a heterogeneous group of neurodegenerative disorders characterized by distinct clinical features, typical histopathological structures, and defined ratio(s) of three-repeat and four-repeat tau isoforms within pathological aggregates.'], ['Enzyme deficiency causes abnormal substrate accumulation in lysosomes, leading to progressive and severe neurodegeneration, somatic pathology and early death.'], ['In particular this review aims to discuss common targets and pathways identified which may underlie the functional deficits associated with both pesticide exposure and neurodegeneration.'], ['DS is characterized by complete or segmental chromosome 21 trisomy, which leads to variable intellectual disabilities, progressive memory loss, and accelerated neurodegeneration with age.', 'The profound memory deficits associated with DS-related AD (DS-AD) have been associated with degeneration of several neuronal populations, but mechanisms of neurodegeneration are largely unexplored.', 'The validation of appropriate DS mouse models that mimic neurodegeneration and memory loss in humans with DS can be valuable in the study of novel preventative and treatment interventions, and may be helpful in pinpointing gene-gene interactions as well as specific gene segments involved in neurodegeneration.'], ["Parkinson's disease (PD) is a neurodegenerative illness characterized by various non-motor symptoms that may contribute to disability, impaired quality of life and shortened life expectancy."], ['It is widely accepted that polynucleotides and polypeptides play fundamental roles in the pathogenesis of neurodegenerative diseases.', 'Amyotrophic lateral sclerosis (ALS) is a motoneuron-degenerative disease, the pathogenesis of which requires both cell autonomous and non-cell autonomous processes.'], ['Neurodegenerative diseases (NDs) are chronic degenerative diseases of the central nervous system (CNS), which affect 37 million people worldwide.', 'As the lifespan increases, the NDs are the fourth leading cause of death in the developed countries and becoming increasingly prevalent in developing countries.', 'Although the large majority of studies do not show support for the involvement of pathogenic aetiology in classical NDs, a number of emerging studies show support for possible association of viruses with classical neurodegenerative diseases in humans.', 'Space does not permit for extensive details to be discussed here on non-viral-induced neurodegenerative diseases in humans, as they are well described in literature.Viruses induce alterations and degenerations of neurons both directly and indirectly.', 'Their ability to attack the host immune system, regions of nervous tissue implies that they can interfere with the same pathways involved in classical NDs in humans.', 'Supporting this, many similarities between classical NDs and virus-mediated neurodegeneration (non-classical) have been shown at the anatomic, sub-cellular, genomic and proteomic levels suggesting that viruses can explain neurodegenerative disorders mechanistically.', 'The main objective of this review is to provide readers a detailed snapshot of similarities viral and non-viral neurodegenerative diseases share, so that mechanistic pathways of neurodegeneration in human NDs can be clearly understood.', 'Viruses can guide us to unveil these pathways in human NDs.', 'This will further stimulate the birth of new concepts in the biological research, which is needed for gaining deeper insights into the treatment of human NDs and delineate mechanisms underlying neurodegeneration.'], ['RESULTS: Patients with SCI who were younger and had more severe neurologic lesions, had higher intense risk-taking attitudes, and experienced depression had significantly lower TTO and SG scores than their counterparts.'], ['We emphasize the importance of neural cell surface M6P receptor as a delivery target of neural cell-directed enzyme replacement therapy (NCDERT) for neurodegenerative metabolic diseases.'], ['OBJECTIVE: Friedreich ataxia (FRDA) is an autosomal recessive, neurodegenerative disease.'], ['The mammalian ortholog of yeast Atg6/Vps30, Beclin 1, is an essential autophagy protein that has been linked to diverse biological processes, including immunity, development, tumor suppression, lifespan extension, and protection against certain cardiac and neurodegenerative diseases.'], ['We investigated whether these properties were maintained in a mouse model of neurodegenerative disease.', 'These results suggest that fragment C of tetanus toxin, TTC, provides a potential therapy for neurodegenerative diseases.'], ['Studies have shown that sirtuins have pathophysiological relevance to neurodegeneration, muscle differentiation, inflammation, obesity, and cancer.'], ['The potential therapeutic benefits from human umbilical cord blood (HUCB) cells for the treatment of injuries, diseases, and neurodegeneration are becoming increasingly recognized.'], ['OBJECTIVE: Considering the short remaining life expectancy with glioblastoma multiforme, numerous patients and their referring physicians are hesitant to use aggressive surgical treatment for fear of greater risk of neurological deterioration.', 'Total tumor resection is not associated with a significantly greater risk for neurological deterioration, either in patients with preoperative functional impairment, or in functionally independent patients.'], ['Demonstrating the validity of this concept will also serve the purpose of identifying the subjects with a neurodegenerative disease without any cognitive complaints yet at a very early stage in clinical studies.'], ['BACKGROUND: Cerebral tissue integrity decline and cerebral blood flow (CBF) alteration are major aspects of motor and cognitive dysfunctions and neurodegeneration.'], ['MRE has been used extensively to study aging and neurodegeneration, and to assess individual cognitive differences in adults, but little is known about mechanical properties of the pediatric brain.'], ["Parkinson's disease (PD) is an age-related neurodegenerative disorder."], ['Our findings suggest that the concordance of rs-fMRI metrics may be useful as a candidate biomarker for neurodegenerative disorders such as AD.'], ['Based on the perioperative BMD and X-ray data, we calculated the prevalence of OP in this special population according to sex, age, and spine degenerative disease.'], ['With an increase in life expectancy, the incidence of chronic degenerative pathologies such as dementia has progressively risen.'], ['However, treatment of flies and primary Schwann cells with an antioxidant suppressed the p.N237S-induced neurodegeneration.'], ['Life expectancy has been increasing, and tissue replacement is increasingly needed in patients suffering from various degenerative disorders of the organs.'], ['Mitochondrial dysfunction has previously been implicated in an array of neurodegenerative disorders.'], ['Ataxia-telangiectasia (AT) is a neurodegenerative disorder characterized by ataxia, telangiectasia, and immunodeficiency.'], ['POI women also experience psychological distress and some studies have shown an increased risk of neurodegenerating diseases.'], ['In addition, when these inhibitors are administered to Drosophila melanogaster expressing human Abeta(1-42) in the central nervous system, a prolonged lifespan, increased locomotor activity, and reduced neurodegeneration is observed.'], ['The mechanism by which loss of Pink1 leads to neurodegeneration is not understood.'], ['Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease afflicting the voluntary motor system.'], ['THERAPY AND OUTCOME: Wolfram syndrome is a progressive degenerative disorder with reduced life expectancy.'], ["The etiology of Parkinson's disease, one of the most frequent neurodegenerative disorders in human, is unknown."], ['As the apparent number of putative tissue and cellular targets for metformin has increased, so has interest in re-purposing metformin to treat other diseases that include polycystic ovary syndrome (PCOS), cancer, neurodegenerative diseases and COVID-19.'], ['It has been shown to confer cognitive reserve that might lessen the impact of brain pathology and its impact on cognitive and motor functioning in a variety of neurodegenerative diseases and, for instance, to influence electrical activity [Begum, T., Reza, F., Ahmed, I., & Abdullah, J. M. (2014).'], ['Concomitantly, chronic diseases such as neurodegenerative diseases have emerged as serious clinical problems.'], ['Neurodegenerative diseases (ND) are among the leading causes of disability and mortality.'], ["AREAS COVERED: After evaluating the period from 2010 to early 2018, the areas covered by the reviewed QSAR based therapeutics patents comprise three main fields (drug development, risk assessment and novel QSAR methodologies), and several areas, from cancer and cancer related symptomatology to neurodegenerative diseases, such as Parkinson's disease, or even monitoring several chemical particles carrier-mediums or interface frontiers.", 'Further, the type of compounds described in these types of patents is likely to see an increase in neurodegenerative diseases therapeutics, as the novel methodologies meet the challenging global health needs as human life expectancy increases.'], ['Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder that affects upper and/or lower motor neurons.'], ['Whether sleep and activity abnormalities are primary molecular disruptions of mutant Huntingtin (mutHtt) expression or result from neurodegeneration is unclear.'], ['With increasing lifespan, the incidence of neurodegenerative diseases increases consistently.', 'Neurodegenerative diseases affect approximately 37 million people worldwide and are an important cause of mortality.', 'In addition to established non-viral-induced reasons for neurodegenerative diseases, neuropathic infections and viruses associated with neurodegenerative diseases have been proposed.', 'Viruses that attack the human immune system can also affect the nervous system and interfere with classical pathways of neurodegenerative diseases.', 'Various studies have supported viral- and non-viral-mediated neurodegeneration at the cellular, molecular, genomic and proteomic levels.', 'The main focus of this review is to illustrate the association between viral infections and both neurodegenerative and neurobehavioral diseases, so that the possible mechanism and pathway of neurodegenerative diseases can be better explained.', 'This information will strengthen new concepts and ideas for neurodegenerative and neurobehavioral disease treatment.'], ['Niemann-Pick C (NPC) disease is an inherited, progressive neurodegenerative disorder caused by mutations in the NPC1 or NPC2 gene that result in an accumulation of unesterified cholesterol in late endosomes/lysosomes (LE/L) and impaired export of cholesterol from LE/L to the endoplasmic reticulum (ER).', 'Recent studies demonstrate that administration of cyclodextrin (CD) to Npc1(-/-) mice eliminates cholesterol sequestration in LE/L of many tissues, including the brain, delays neurodegeneration, and increases lifespan of the mice.'], ['Because the symptoms of neurodegenerative diseases generally onset in mid- to late-life, a concomitant increase in the number of persons afflicted with these devastating diseases has occurred.', 'Developing therapies for neurodegenerative diseases is of the highest priority due to the enormous cost of medical care required, as well as for the human suffering involved.', 'The numerous intriguing advances in antibody-based therapies for neurodegenerative diseases are discussed in this review.'], ['Exposure to neurotoxic agents during development or over a significant portion of the lifespan may also result in acceleration of age-related neurodegenerative diseases.'], ['Both experimental and clinical reports indicate the role of intestinal dysbiosis and microbiota host interaction in neurodegeneration.'], ['RESULTS: After the treatment, only the treated group displayed a decrease in C reactive protein (CRP) p<0.001, an increase in serum free carnitine and acetyl carnitine (p<0.05), in Mini Mental state (MMSE) p<0.0001 and 6-walking distance (p<0.0001); ALCAR group vs. placebo group showed a decrease in HDL cholesterol and in CRP (p<0.01), an increase in MMSE score (p< 0.001) and in 6-walking distance (p<0.001) Conclusions: ALCAR treatment delays the incidence and severity of onset in prefrail subjects of degenerative disorders of the elderly, with improvement in memory and cognitive processes.'], ['PURPOSE: This retrospective study investigates oral health and oral care in patients with neurodegenerative and cerebrovascular diseases (CVDs) treated in a dental facility for people with disabilities.', 'RESULTS: Patients with neurodegenerative or CVD had a significantly higher DMFT (21.2 +- 5.8 vs. 18.3 +- 5.9), more decayed teeth (4.3 +- 4.8 vs. 1 +- 1.9), fewer filled teeth (7.9 +- 5.5 vs. 11 +- 5.6), and a higher number of surgical (39.5% vs. 20%) treatments but significantly less conservative (49.3% vs. 73.3%) and prosthetic (15.1% vs. 56.7%) treatments than the control group (p< 0.05).', 'The frequency of toothbrushing and the use of an electric toothbrush were related to lower DMFT in patients with neurodegenerative and CVD.'], ['We focus on 39 general medical conditions to simplify the presentation of results, which cover 10 broad categories: circulatory, endocrine, pulmonary, gastrointestinal, urogenital, musculoskeletal, hematologic, mental, and neurologic conditions and cancer.'], ['The accumulation of epigenetic alterations over the lifespan may contribute to neurodegeneration.', 'The aim of the present study was to identify epigenetic biomarkers for improving diagnostic efficacy in patients with neurodegenerative diseases.', 'We analyzed global DNA methylation, chromatin remodeling/histone modifications, sirtuin (SIRT) expression and activity, and the expression of several important neurodegeneration-related genes.', 'DNA methylation, SIRT expression and activity and neuregulin 1 (NRG1), microtubule-associated protein tau (MAPT) and brain-derived neurotrophic factor (BDNF) expression were reduced in buffy coat samples from patients with neurodegenerative disorders.', 'Our data suggest that these epigenetic biomarkers may be useful in clinical practical for the diagnosis, surveillance, and prognosis of disease activity in patients with neurodegenerative diseases.'], ['Prion diseases are fatal, infectious, and incurable neurodegenerative disorders caused by misfolding of the cellular prion protein (PrPC) into the infectious isoform (PrPSc).'], ["BACKGROUND: Multiple system atrophy (MSA) is a rare neurodegenerative disorder, and its parkinsonian variant can be difficult to delineate from Parkinson's disease (PD)."], ['The progressive reduction of its biosynthesis along the lifespan is being considered as one of the causes underlying neuronal loss in aged people and severe neuronal decline in neurodegenerative diseases.'], ['Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with a median lifespan of 2-3 years after diagnosis.'], ['Importantly, Mlf1 deletion reverses B- and T-cell lymphopenia and significantly ameliorates the progressive striatal and cerebellar neurodegeneration observed in Hax1-/- mice, with a doubling of the lifespan of Mlf1-/-/Hax1-/- animals compared to Hax1-/- animals.'], ['Autosomal recessive cerebellar ataxia (ARCA) comprises a large and heterogeneous group of neurodegenerative disorders.'], ["Alzheimer's disease (AD) is a neurodegenerative disorder which mainly affects elderly population."], ["These data indicate that neurogenesis in the adult brain is more widespread than previously thought and may have implications for our understanding of the pathogenesis and treatment of neurodegenerative disorders such as Parkinson's disease."], ['BACKGROUND: The autosomal dominant spinocerebellar ataxias (SCAs) are a clinically and genetically heterogeneous group of neurodegenerative disorders.'], ['We compared the life-span of myoblasts from eight DMD patients with controls: three individuals with no known neuromuscular disease, three DMD carriers, and three patients with other muscle degenerative diseases.'], ['GM1-gangliosidosis (GM1) is a rare neurodegenerative disorder leading to early mortality and causing progressive decline of physical skills and cerebral functioning.'], ['In neurodegenerative diseases, the value of sDTI is promising but not yet well understood.', 'These results may also encourage the usage of sDTI in other neurodegenerative diseases with spinal cord involvement to explore its capability as selective biomarkers.'], ['Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease that causes motor neuron degeneration.', 'The efficacy of therapeutic hypothermia in chronic neurodegenerative disorders has not been examined.'], ["Lifelong bilingualism may contribute to cognitive reserve (CR) in neurodegenerative diseases as shown by a delay of the age at symptom onset in bilinguals with Alzheimer's disease (AD) and Mild Cognitive Impairment (MCI)."], ['PURPOSE: To compare the odds of central neurodegenerative diseases in patients with open-angle glaucoma (OAG) with the odds in patients without glaucoma (control patients).', "METHODS: An electronic query of patient records at Duke University Health System was performed to identify patients with and without diagnoses of OAG, amyotrophic lateral sclerosis (ALS), Alzheimer's disease (AD), Parkinson's disease (PD), vascular dementia (VD), senile dementia (SD), mild cognitive impairment (MCI), and other neurodegenerative diseases.", 'MAIN OUTCOME MEASURES: Odds ratios comparing the odds of each neurodegenerative disease in OAG patients with the odds in control patients.', 'After adjusting for age, race, and gender, the OR comparing the odds of each neurodegenerative disease in OAG patients with the odds in control patients were as follows: for AD: adjusted OR, 0.84; 95% confidence interval (CI), 0.77-0.93; for ALS: adjusted OR, 0.28; 95% CI, 0.14-0.49); for PD: adjusted OR, 1.00; 95% CI, 0.89-1.13; for VD: adjusted OR, 1.11; 95% CI, 0.99-1.25; for SD: adjusted OR, 1.30; 95% CI, 1.19-1.41; for MCI: adjusted OR, 2.00; 95% CI, 1.79-2.22; and for other neurodegenerative disease: adjusted OR, 1.79; 95% CI, 1.51-2.10.', 'CONCLUSIONS: Open-angle glaucoma patients may have increased odds of SD, MCI, and other neurodegenerative diseases.'], ['Mitochondrial toxicity is involved in many diseases such as cancer, neurodegeneration, type 2 diabetes, cardiovascular diseases and autoimmune diseases.'], ['Amyotrophic lateral sclerosis (ALS) is a common neurodegenerative disorder, but little is known about the exact causes and pathophysiology of this disease.'], ["Because neurogenesis has been implicated in a variety of psychiatric and neurodegenerative illnesses, understanding how reproductive experience alters new neuron production in maternal mammals has far-reaching implications for women's health and wellness across the lifespan."], ['However, in Drosophila models of Tauopathy, neurodegeneration has been observed in the absence of abundant Tau filaments.', 'Flies expressing wild-type Tau-383 showed MC-1 staining, Tau hyperphosphorylation, and neurodegeneration.', 'By contrast, flies expressing Delta306-311 Tau-383 had less MC-1 staining, reduced Tau hyperphosphorylation, and no detectable neurodegeneration.', 'These findings demonstrate that the assembly of Tau into beta-sheets is necessary for neurodegeneration.'], ['Neurodegenerative diseases and chronic cigarette smoking are associated with increased cerebral oxidative stress (OxS).'], ['Amyotrophic lateral sclerosis is a late-onset degenerative disease affecting motor neurons in the spinal cord, brainstem, and motor cortex.'], ['Adult onset neuronal lipofuscinosis (ANCL) is a human neurodegenerative disorder characterized by progressive neuronal dysfunction and premature death.', 'Mutant dnj-14 worms also exhibited age-dependent neurodegeneration of sensory neurons, which was preceded by severe progressive chemosensory defects.', 'In contrast to other worm neurodegeneration models, activation of the Sirtuin, SIR-2.1, was not required, as sir-2.1; dnj-14 double mutants showed full lifespan rescue by resveratrol.', 'The Sirtuin-independent neuroprotective action of resveratrol revealed here suggests potential therapeutic applications for ANCL and possibly other human neurodegenerative diseases.'], ['Spinal muscular atrophy (SMA), a recessive neurodegenerative disease, is characterized by the selective loss of spinal motor neurons.'], ['Intramedullary spinal cord metastases (ISCM) are rare spinal cord neoplasms associated with severe neurological deterioration and poor life expectancy.'], ['OBJECTIVE: Describe the natural history of spinopelvic alignment parameters and their behavior in patients with degenerative spinal deformity.'], ['A class of compounds called STACs, which were identified as activators of Sir2/SIRT1 NAD+-dependent deacetylases, extend the lifespans of multiple species in a Sir2-dependent manner and can delay the onset of age-related diseases such as cancer, diabetes and neurodegeneration in model organisms.'], ['It also plays a neuroprotective role by modulating several biological pathways such as apoptosis, DNA repair, protein aggregation, and inflammatory processes associated with ageing and neurodegenerative diseases.', 'In this review, we have presented an updated Sirtuins and its role in ageing and age-related neurodegenerative diseases (NDDs).'], ["Aggregation of proteins is a prominent hallmark of virtually all neurodegenerative disorders including Alzheimer's, Parkinson's and Huntington's diseases.", 'The results obtained demonstrate that our theranostics platform, integrating photothermal therapy without drugs or other chemicals, combined with advanced imaging to monitor photothermal ablation of aggregates, initiates systemic recovery and thus validates the concept of aggregate-disruption treatments for neurodegenerative diseases in humans.'], ["Alzheimer's disease (AD) is a severe neurodegenerative disease which impacts the quality of life in elderly patients and imposes a significant burden to families and caregivers."], ['BACKGROUND: Primary knee osteoarthritis remains a difficult-to-control degenerative disease.'], ['This pleiotropic kinase has been implicated in various age-related diseases including tumorigenesis, neurodegeneration and diabetes.'], ['In contrast, the 4R isoform leads to greater neurodegeneration and impairments in learning and memory.'], ['OBJECTIVE: To determine the incidence and effects of tricuspid regurgitation (TR) after surgery for mitral valve (MV) repair for mitral regurgitation (MR) due to degenerative disease.', 'CONCLUSIONS: Preoperative TR in patients with MR due to degenerative diseases was associated with longstanding MV disease and adversely affected long-term survival after MV repair.'], ["METHODS/DESIGN: The aim of the Informal Carers of Elderly cohort is to define, through a longitudinal study, profiles of caregivers of older patients with a diagnosis of one of the following diseases: cancer (breast, prostate, colorectal), neurodegenerative diseases (Parkinson's disease, Alzheimer's disease and similar diseases), neurovascular diseases (stroke), sensory diseases (age-related macular degeneration (AMD)) and heart disease (heart failure)."], ["Human tauopathies such as Alzheimer's Disease (AD), frontotemporal dementia with parkinsonism linked to chromosome 17 (FTDP-17), Pick's disease etc., are a group of neurodegenerative diseases which are characterized by abnormal hyperphosphorylation of tau that leads to formation of neurofibrillary tangles.", 'Recapitulating several features of human neurodegenerative disorders, the Drosophila tauopathy model displays compromised lifespan, locomotor function impairment, and brain vacuolization in adult brain which is progressive and age dependent.'], ["Among these diseases are neurodegenerative diseases, such as Alzheimer's and Parkinson's diseases."], ['However, autophagy also crucially contributes to the development of age-related human pathologies, including cancer and neurodegeneration.', 'The PtdIns3P effector function of human WIPI proteins appears to be compromised in cancer and neurodegeneration, and WIPI genes and proteins might present novel targets for rational therapies.'], ['These findings have led to the hypothesis that ET is a syndrome produced by at least two neurodegenerative diseases with more widespread clinical consequences than previously appreciated.'], ['Neuroimaging in younger adults and research on neurodegenerative disorders suggests that perceptual-motor learning relies on the striatum, cerebellum, and prefrontal cortex.'], ['Invertebrate models of several human neurodegenerative diseases have recently been described.', 'Because the basic cell biology of the nervous system is very similar in vertebrates and invertebrates, the sophisticated and rapid genetic analysis feasible in Drosophila and C. elegans promises significant insight into human neurodegenerative syndromes.'], ['OBJECTIVE AND IMPORTANCE: With an aging population and increasing utilization of both cochlear implants (CI) to treat hearing loss and deep brain stimulation (DBS) to treat neurodegenerative movement disorders, more patients will be sequentially implanted with the two devices.'], ['With the increase in life expectancy, the incidence of neurodegenerative disorders and their impact worldwide has been increasing in recent years.', "Neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, and Huntington's disease, have complex and varied mechanisms of pathogenesis.", 'In addition, the association of physical frailty with dementia and neurodegenerative disorders has been demonstrated.', 'Importantly, the activation of SIRT1 has been shown to have very relevant therapeutic potential against neurodegeneration.', 'Nevertheless, few studies have attempted to connect the therapeutic reestablishing of SIRT1 as an approach against circadian disruption in neurodegenerative diseases.', 'In this review, we address: circadian rhythms as an important early biomarker of neurodegenerative disorders; mechanisms for SIRT1 activation and the novel sirtuin-activating compounds (STACs); SIRT1 circadian paradox and subsequent studies in an unprecedented way in the literature; the beneficial role of SIRT1 activation in neurodegeneration; innovative proposals of how circadian-based interventions (e.g., SIRT1 activators) may become an important therapeutic approach against neurodegenerative disorders and how non-pharmacologic interventions (e.g., Mediterranean-style diet) might help in the prevention and/or treatment of these high-burden disorders, while tackling frailty and enhancing robustness.'], ['RECENT FINDINGS: Life expectancy is increasing in the United States, and, accordingly, the prevalence and incidence of dementia associated with age-related neurodegenerative brain disease are rising.'], ['Declines in NAD+ levels are associated with metabolic and inflammatory diseases, aging, and neurodegenerative disorders.'], ['BACKGROUND: Early neurological deterioration (END) occurs in patients with pontine infarction that is adversely associated with a long-term functional outcome.'], ['RESULTS: RBD, with its core objective diagnostic feature of REM-without-atonia (RWA) documented by video-polysomnography, can emerge during the entire lifespan, and can initially present as an idiopathic (isolated) condition (iRBD), or can be associated with a broad spectrum of disorders including narcolepsy, alpha-synuclein neurodegenerative disorders (esp.'], ['Our results suggest that low PF is associated with faster cognitive decline, and both neurodegeneration and vascular brain lesions may underlie the association.'], ['Therefore, there is a great interest in the identification of effective autophagy enhancers with potential nutraceutical or pharmaceutical properties to ameliorate age-related diseases, such as neurodegenerative disorders, and/or promote longevity.'], ['Major etiologies of hypoperfusion include large artery, small artery, and venous disease; other vascular conditions; global hypoxic-ischemic injury; and neurodegeneration.'], ["Alzheimer's Disease (AD) is a devastating neurodegenerative disorder of the brain, clinically characterised by cognitive deficits that gradually worsen over time."], ["A hallmark common to many age-related neurodegenerative diseases, such as Alzheimer's disease (AD), Parkinson's disease (PD), and amyotrophic lateral sclerosis (ALS), is that patients develop proteinaceous deposits in their central nervous system (CNS).", 'As population demographics in many countries continue to shift to higher life expectancy, the incidence of neurodegenerative diseases is also rising.'], ["Since variations in 3',5'-cyclic adenosine monophosphate, 3',5'-cyclic guanosine monophosphate, and/or nitric oxide levels interfere with downstream pathways involved in memory processes, evidence supporting the potential of phosphodiesterase (PDE) inhibitors in contrasting neurodegeneration should be critically considered.", 'Original computational studies were performed to rationalize the emerging evidence that suggests the role of PDE5 inhibitors as multi-target agents against neurodegeneration.'], ['Our results suggest TDP-1/TDP-43 potentiates HASN mediated neurodegeneration in C. elegans.', 'This study indicates a multifunctional role for TDP-1/TDP-43 in neurodegeneration involving HASN.'], ['Moreover, ncRNAs have been found to intricately and dynamically regulate various signaling pathways in neurodegeneration.', 'As such, some antisense transcripts and microRNAs are known to directly affect neurodegeneration in disease contexts.', 'Thus, further understanding of ncRNA biogenesis and effects might aid the discovery of diagnostic biomarkers or development of effective therapeutics for neurodegenerative disorders.', 'Here, we review the ncRNAs that have so far been identified in major neurodegenerative disease etiology and the mechanisms that link ncRNAs with disease-specific phenotypes, such as HTT aggregation in HD, alpha-synuclein in PD, and Abeta plaques and hyperphosphorylated Tau in AD.', 'We also summarize the known lncRNA/miRNA/mRNA networks that participate in neurodegenerative diseases, and we discuss ncRNA-related treatments shown to delay disease onset and prolong lifespan in rodent models.'], ['Increased systemic oxidatively generated nucleoside damage have been found in some neurodegenerative disorders and in BD.'], ["Alzheimer's disease is the most common age-related neurodegenerative disorder and its burden on patients, families, and society grows significantly with lifespan."], ['Understanding how the UPRER modulates pathological tau accumulation will inform neurodegenerative disease mechanisms.'], ['Here, we demonstrate in a well-characterized mouse model of NP-C that a single administration of AAV-mediated gene therapy to the brain can significantly extend lifespan, improve quality of life, prevent or ameliorate neurodegeneration, reduce biochemical pathology and normalize or improve various indices of motor function.'], ['PURPOSE: Multiple sclerosis is a degenerative neurological disease that affects 2.1 million people worldwide.', 'Implications for Rehabilitation Multiple sclerosis is a chronic degenerative neurological disease that the individual lives with for a majority of the lifespan.'], ["A signature feature of age-related neurodegenerative proteinopathies is the misfolding and aggregation of proteins, typically amyloid-beta (Abeta) in Alzheimer's disease (AD) and alpha-synuclein (alpha-syn) in Parkinson's disease (PD), into soluble oligomeric structures that are highly neurotoxic.", 'Taken together, our findings suggest that the plant-derived extracts interfere with shared mechanisms of neurodegeneration in AD and PD.', 'Our work therefore opens new avenues for developing therapeutic applications of these natural plant extracts in the treatment of amyloidogenic neurodegenerative disorders.'], ['Unfortunately, as humans age, they become more prone to suffer from neurodegenerative diseases and neurotoxicity.', 'We discuss whether polyphenols obtained from diet or food supplements are an effective strategy to prevent or treat neurodegeneration.', 'We also discuss the safety, mechanisms of action, and the current and future relevance of polyphenols in clinical treatment of neurodegenerative diseases.', 'As populations age, it is important to discuss the dietary strategies to avoid or counteract the effects of incurable neurodegenerative disorders, which already represent an enormous financial and emotional burden for health care systems, patients, and their families.'], ['Due to a prolonged life expectancy worldwide, the incidence of age-related neurodegenerative disorders such as glaucoma is increasing.'], ['Parkinson Disease (PD) and Huntington Disease (HD) are degenerative neurological diseases, which can result in impairments and activity limitations affecting the upper extremities from early in the disease process.'], ['Amyotrophic Lateral Sclerosis (ALS) is a devastating neurodegenerative disease causing progressive paralysis of the patient followed by death on average 3-5 years after diagnosis.'], ['Throughout Southeast Asia, the number of people living with chronic conditions and degenerative disease has increased proportionately and absolutely.'], ["Idiopathic Parkinson's disease (IPD) represents a common neurodegenerative disorder."], ['The evidence that the elderly are more prone to develop pathologies such as cancer, diabetes and degenerative diseases, together with data showing that the elderly population is steadily increasing, has stimulated an important effort to find specific countermeasures to physiological ageing.'], ['The neuroprotective and anti-inflammatory effects of peroxisome proliferator-activated receptor gamma [PPAR-gamma] agonists decrease cell death and halt the increase in neurodegeneration, which is why they have been given a lot of importance in research.', 'Antidiabetic and anti-inflammatory effects have been observed to be generated by pioglitazone [PG], a selective peroxisome proliferator-activated receptor gamma [PPAR-gamma] agonist that regulates neural plasticity in various neurodegenerative disorders.'], ['Reducing the burden of cell senescence in animal models of cardiometabolic disorders, inflammatory conditions, neurodegenerative diseases, and cancer using pharmaceutical approaches that selectively target senescent cells (ie, senolytics) or that suppress senescence-associated secretory phenotype (ie, senomorphics) holds great promise for the management of chronic age-associated conditions.'], ['We also discuss new evidence indicating that early neuroprotective pathways modulated by Lf could prevent neurodegeneration through anti-inflammatory and immunomodulatory processes.'], ["BACKGROUND: Sporadic or late onset Alzheimer's disease (LOAD) is a multifactorial neurodegenerative disease with aging the most known risk factor."], ["Furthermore, neurodegeneration is accelerated in patients with MS due to the nervous system's loss of remyelination capacity."], ['However, the molecular mechanism by which TDP-43 aggregates form and cause neurodegeneration remains poorly understood.', 'Here we characterized PPIA knock-out mice throughout their lifespan and found that they develop a neurodegenerative disease with key behavioural features of frontotemporal dementia, marked TDP-43 pathology and late-onset motor dysfunction.'], ['Amyotrophic lateral sclerosis (ALS) is an adult-onset neurodegenerative disorder caused by loss of motor neurons.'], ['Chronic low levels of SMN cause accumulation of co-transcriptional R-loops and DNA damage leading to genomic instability and neurodegeneration in SMA.', 'ZPR1 reduces neurodegeneration in SMA mice and prevents degeneration of cultured primary spinal cord neurons derived from SMA mice.', 'In conclusion, ZPR1 is critical for preventing accumulation of co-transcriptional R-loops and DNA damage to avert genomic instability and neurodegeneration in SMA.'], ['However, it is still not fully understood how these mutations lead to neurodegeneration.'], ['Our data also reinforce a novel potential link between ALS and spinal bulbar muscular atrophy (SBMA), another motor neurodegenerative disease mediated by reduced AR function in motor neurons.'], ['INTRODUCTION: Advances in the treatment of HIV infection in the last decades have increased life expectancy of these patients and raise the question of what kind of effect chronic infection and its treatment might exert on the behavior of age-related conditions such as neurodegenerative diseases.', 'DISCUSSION: These findings suggest that HIV infected individuals might be at a higher risk for developing parkinsonism as a manifestation of early neurodegeneration.'], ['This extension of overall survival did not come at the cost of neurological deterioration.'], ['However, the mechanism underlying ApoE4-mediated neurodegeneration remains unclear.', 'We created a transgenic model of neurodegenerative disorder by expressing epsilon3 and epsilon4 isoforms of human ApoE in the Drosophila melanogaster.', 'The genetic models exhibited progressive neurodegeneration, shortened lifespan and memory impairment.', 'Genetic interaction studies between amyloid precursor protein and ApoE in axon pathology of the disease revealed that over expression of hApoE in Appl-expressing neurons of Drosophila brain causes neurodegeneration.', 'Moreover, acute oxidative damage in the hApoE transgenic flies triggered a neuroprotective response of hApoE3 while chronic induction of oxidative damage accelerated the rate of neurodegeneration.'], ['The neuronal ceroid-lipofuscinoses (NCL) is a group of neurodegenerative disorders characterized by epilepsy, visual failure, progressive mental and motor deterioration, myoclonus, dementia and reduced life expectancy.', 'Despite advances in the diagnosis of neurodegenerative disorders mutations in these genes may cause similar phenotypes, which rends difficult accurate candidate gene selection for direct sequencing.'], ["There is no clear evidence proving or disproving that ionising radiation is causally linked with neurodegenerative diseases such as Parkinson's and Alzheimer's.", 'Thus, we want to highlight in general the potential similarities of both the neurodegenerative and radiation-induced pathways.', 'We will propose a mechanistic model for radiation-induced neurodegeneration pointing out mitochondria as a key element.', 'This includes effects of oxidative stress and neuroinflammation-all fundamental players of neurodegenerative diseases.'], ['In this regard, the nematode roundworm, Caenorhabditis elegans, is ideal for examining age-dependent neurodegenerative disease studies.', 'Through expression of the human PD-associated protein (alpha-synuclein in the worm dopamine neurons), neurodegeneration is observed in an age-dependent manner.', 'Here we provide an overview of collaborative studies we have conducted that collectively demonstrate the usefulness of the nematode model to discern functional effectors of dopaminergic neurodegeneration and ER stress that translate to mammalian data in the fields of PD and dystonia.'], ['The Mediterranean diet is associated with a lower incidence of chronic degenerative diseases and higher life expectancy.'], ['Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease associated with a life expectancy of approximately 3 years after symptom onset, but the range of survival extends from a few months for some to decades for approximately 5% of patients.'], ['PMD (Pelizaeus-Merzbacher disease) is a rare neurodegenerative disorder that impairs motor and cognitive functions and is associated with a shortened lifespan.', 'Because inflammation is believed to contribute to axonal degeneration in multiple sclerosis and other neurodegenerative diseases, inflammation in mammals with increased Plp1 gene dosage may also contribute to axonal degeneration described in patients and rodents with PLP1 increased gene dosage.'], ['This study aims to validate previous results in a larger cohort and evaluate the diagnostic accuracy of tear biomarkers to discriminate between individuals with and without neurodegeneration as determined by hippocampal atrophy.'], ['Introduction: Aging brings progressive changes in the physiology of the musculoskeletal system that leads to postural changes and degenerative diseases in elderly.'], ['Amyotrophic lateral sclerosis (ALS) is a highly complex and heterogeneous neurodegenerative disease that affects motor neurons.'], ['From the evidence collected, CSF played an important role in behavioral changes and may be associated with neurodegenerations.'], ['Elevating and/or restoring PGRN levels is an attractive therapeutic strategy and is being investigated for neurodegenerative diseases through multiple mechanisms of action.'], ["As global life expectancy is constantly rising, the early detection of age-related, neurodegenerative diseases, such as Parkinson's disease, is becoming increasingly important."], ['For adult patients, neurodegenerative/memory disorders received TNP evaluations at a higher rate during PC and RO.', 'Data from the RO period suggest that in-person evaluations not surprisingly remain the mainstay; however, for adult patients, and especially older adults with neurodegenerative/memory disorders, TNP may provide an important option for delivery of neuropsychological evaluations.'], ['Mitochondrial dysfunction notably affects a wide range of disorders in aged individuals, including neurodegenerative diseases, cancers, and even senescence.'], ['Patients with multiple system atrophy (MSA), a progressive neurodegenerative disorder of adult onset, were found less than 9 years of life expectancy after onset.'], ['BACKGROUND: Reactive oxygen species are involved in the etiology and progress of many kinds of diseases such as cancer, cardiovascular diseases, inflammatory and neurodegenerative disorders.'], ['Although the efforts for unravelling the complex immunometabolic signaling pathways to explain the association of obesity with type 2 diabetes, cardiovascular diseases, cancer, neurodegenerative diseases and psychiatric disorders, we still do not have all the picture to design effective therapeutic to fight these immunometabolic disease clusters.', 'While the role of dopaminergic pathways in immune-mediated diseases has been intensively investigated in neurodegenerative diseases, dopaminergic immunomodulation in obesity-associated inflammation is largely unknown.'], ['BACKGROUND: Amyotrophic lateral sclerosis (ALS) is an adult-onset neurodegenerative disease progressively affecting upper and lower motor neurons in the brain and spinal cord.'], ['Cellular therapy represents a novel option for the treatment of neurodegenerative disorders such as amyotrophic lateral sclerosis (ALS).'], ["Parkinson's disease is a degenerative disorder of the central nervous system affecting the substantia nigra in the midbrain."], ["Neurodegenerative diseases (NDs), such as Alzheimer's disease and Parkinson's disease, are among the most debilitating neurological disorders, and as life expectancy rises quickly around the world, the scientific and clinical challenges of dealing with them will also increase dramatically, putting increased pressure on the biomedical community to come up with innovative solutions for the understanding, diagnosis, and treatment of these conditions.", 'Despite several decades of intensive research, there is still little that can be done to prevent, cure, or even slow down the progression of NDs in most patients.', 'Here, we analyze the challenges and potential benefits of using human brain tissue for proteomics research toward NDs.'], ['Amyotrophic lateral sclerosis (ALS) is an incurable, chronic, fatal neuro-degenerative disease characterized by progressive loss of moto-neurons and paralysis of skeletal muscles.'], ['As loss of protein homeostasis is a feature of many sporadic and inherited forms of neurodegenerative disorders, the pharmacological inhibition of the IGF-1 receptor represents a promising potential therapeutic strategy for currently untreatable neurodegenerative disorders.', 'However, additional studies are required to determine whether this approach is suitable to delay pathology in clinically relevant models of neurodegenerative disorders.'], ['Inhibition of the insulin/insulin-like growth factor signalling pathway increases lifespan and protects against neurodegeneration in model organisms, and has been considered as a potential therapeutic target.', 'The novel link we describe here has important consequences for the interpretation of genetic experiments in mammalian systems and for evaluating the potential of targeting the IGF-1R receptor or modulating its signalling through the downstream pathway for therapeutic purposes under clinically relevant conditions, such as neurodegenerative diseases, where autophagy stimulation is considered beneficial.'], ['During the epidemiologic transition from rural to industrial in countries such as the United States and Canada, nutritional deficiencies and infectious diseases made way for degenerative diseases such as cardiovascular diseases, cancer, overweight/obesity, and diabetes.'], ['At later ages, multiple studies found evidence suggesting that n-3 PUFA can protect against neurodegeneration and possibly reduce the chance of developing cognitive impairment.'], ['Parkinson disease (PD) is a chronic progressive degenerative disorder that affects over 6 million people worldwide.'], ['These preliminary results further imply that NSC transplantation strategies might have therapeutic promise in treating neurodegenerative diseases often characterized by isolated or global neuronal and glialloss.', 'Both chemotropic and exogenous cell graft mechanisms ofCNS repair are under review for their therapeutic value and it is hoped that one day, these findings will be applied to human neurodegenerative disorders.', "The potential applications for NSC transplantations to treat both isolated and global neurodysfunction in humans are innumerable; these prospects include inherited pediatric neurodegenerative and metabolic disorders such as lysosomal storage diseases including leukodystrophies, Sandhoff disease, hypoxic-ischemic encephalopathy and adult CNS disorders characterized by neuronal or glial cell loss such as Parkinson's disease, multiple sclerosis, stroke and spinal cord injury."], ["With increasing life expectancy, a growing number of individuals are being affected by Parkinson's Disease (PD), a Neurodegenerative Disease (ND)."], ['BACKGROUND: Subcortical brain structures play a key role in pathological processes of age-related neurodegenerative disorders.', 'Mounting evidence also suggests that early-life factors may have an impact on the development of common late-life neurological diseases, including genetic factors that can influence both brain maturation and neurodegeneration.'], ['BACKGROUND: Niemann-Pick disease type C (NPC) is an ultra-rare, progressive, genetic disease leading to impaired lysosomal function and neurodegeneration causing serious morbidity and shortened life expectancy.'], ['These results suggest that curcumin may be able to serve as a potential preventive and therapeutic agent in neurodegenerative brain disorders.'], ['Currently, there is no cure for AD and, once the neurodegenerative disorders are established, patients use pharmacologic therapy to slow the progression of the symptoms and require appropriate care to manage their condition.'], ['Dementia with Lewy bodies is the second most common form of neurodegenerative dementia, yet scarce evidence is available about its prognosis and natural history, which are crucial to inform clinical practice and research.'], ['Amyotrophic lateral sclerosis (ALS) is a devastating progressive neurodegenerative disease characterized by the selective death of motor neurons.', 'Moreover, an increase of IP3R2 expression was observed in other models of chronic and acute neurodegeneration.'], ['A clear link exists between the extension of life expectancy throughout the world and the increased incidence of age-related neurodegenerative disorders.', 'Attempts to develop new therapies have been hampered mainly because of gaps in our current knowledge about the pathogenic mechanism underlying neurodegeneration, making difficult the identification of targets for new drug development, and also because of the lack of biomarkers essential for early diagnosis, patient stratification and follow up of treatment.'], ['They presented a very similar and particular phenotype associating distinctive facial gestalt, severe developmental delay, megacalycosis, progressive neurodegeneration, alacrimi, corneal hypoesthesia and deafness.'], ["BACKGROUND: Microtubule associated protein tau is the major component of the neurofibrillary tangles (NFTs) found in the brains of patients with Alzheimer's disease and several other neurodegenerative diseases."], ['Given the increased life expectancy of human immunodeficiency virus (HIV) infected individuals treated with combination antiretroviral therapy (cART) and the ongoing inflammation observed in the brains of these patients, it is likely that premature neurodegeneration as measured by phospho-tau (p-tau) or increased total tau (t-tau) protein may become an increasing problem.'], ['The human DJ-1 protein is associated with cancer and neurodegenerative disorders, such as Parkinson disease.'], ['The Hexb-/- mouse model of SD shows a progressive neurodegenerative phenotype similar to the human equivalent.', 'Tumor necrosis factor-alpha (TNFalpha), a key modulator of the CNS immune response in models of neurodegeneration, is a hallmark of this activation.', 'This study reveals TNFalpha as a neurodegenerative cytokine mediating astrogliosis and neuronal cell death in SD and points to TNFalpha as a potential therapeutic target to attenuate neuropathogenesis.'], ['Further, we assessed if a treatment with the P2X7 receptor antagonist Brilliant Blue G - a dye that can cross the blood-brain barrier, has low toxicity, and has exhibited therapeutic effects in animal models of neurodegenerative diseases - impact on the disease progression, in male and female ALS mice.'], ['Altered protein homeostasis underlies degenerative diseases triggered by misfolded proteins, including spinal and bulbar muscular atrophy (SBMA), a neuromuscular disorder caused by a CAG/glutamine expansion in the androgen receptor.'], ['Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder affecting predominantly motor neurons.', 'ISGs in astrocytes were activated specifically by endoplasmic reticulum stress-induced neurodegeneration in vitro, implicating a similar process in the presymptomatic stage of SOD1 mutant mice.'], ['Of particular note is the dramatic rise in the incidence of neurodegenerative diseases.', 'AREAS COVERED IN THIS REVIEW: The present review discusses some of the drugs that are now under development with antiapoptotic activity or currently on the market that may have a potential application for the treatment of neurodegenerative diseases.', 'In addition, we discuss the potential application of several compounds, such as NMDA antagonists, JNK inhibitors and GSK-3 inhibitors, for the treatment of neurodegenerative disorders.', 'WHAT THE READER WILL GAIN: This article will review recent developments in the field of apoptosis inhibitors, which might provide future tools for the treatment of the neurodegenerative diseases.', 'TAKE HOME MESSAGE: The treatment of neurodegenerative diseases is a major challenge in medicine.', 'New developments in the field of apoptosis inhibitors may provide future tools for the treatment of the aforementioned neurodegenerative diseases.'], ['These results suggest that Regrapex-R is a potent free radical scavenger, a mitochondrial protector, and a candidate for further studies to assess its ability to protect against neurodegenerative disease and potentially extend lifespan.'], ['The presence of primary neurodegeneration, mental retardation, skin and immune system involvement, or renal tubular acidosis may point to rarer osteopetrosis variants, whereas onset of primarily skeletal manifestations such as fractures and osteomyelitis in late childhood or adolescence is typical of ADO.'], ['Nucleated cell therapy, that is, cellular transplant, is a promising new area of study with its proven efficacy in neuro-degenerative disorders, hematopoietic disorders, diabetes and trauma-induced tissue loss, to name a few.'], ['(3) This mismatch between biology and lifestyle fosters development of degenerative diseases.'], ['Although there is no firm evidence to support the "ideal" or even "appropriate" healthy level of dietary fat, the habitual fat consumption pattern in Japan seems to be a criterion for the recommended allowance both in the quantitative and qualitative points of view as judged from the life expectancy and the incidence of degenerative diseases.'], ["In addition degenerative arthropathies, such as Mseleni's disease, present in some parts of the tropics, merit further study."], ['We also discuss both the therapeutic potential and side effects of IF and PF with a focus on cancer, autoimmunity, neurodegeneration and metabolic and cardiovascular disease.'], ["Alzheimer's disease (AD) is an untreatable neurodegenerative disease that initially manifests as difficulty to remember recent events and gradually progresses to cognitive impairment."], ['Mutants in the gene encoding mitochondrion-associated protein LRPPRC were found to be associated with French Canadian Type Leigh syndrome, a human disorder characterized with neurodegeneration and cytochrome c oxidase deficiency.'], ['Amyotrophic lateral sclerosis (ALS) is a multifactorial neurodegenerative disease involving motor neuron (MN) degeneration in the spinal cord, brain stem and primary motor cortex.'], ['Nitrosative stress, a potential factor in human neurodegeneration, stimulated Sp1 expression and human p11 promoter activity, at least in part, through a Sp1-binding site.'], ['Amyotrophic lateral sclerosis (ALS) is a rapidly progressing neurodegenerative disease that is characterized by motor neuron loss and that leads to paralysis and death 2-5 years after disease onset.'], ['Homozygous dGBA1b mutants exhibit shortened lifespan, locomotor and memory deficits, neurodegeneration, and dramatically increased accumulation of ubiquitinated protein aggregates that are normally degraded through an autophagic mechanism.'], ["Production of protein containing lengthy stretches of polyglutamine encoded by multiple repeats of the trinucleotide CAG is a hallmark of Huntington's disease (HD) and of a variety of other inherited degenerative neurological and neuromuscular disorders."], ['Environmental manganese (Mn) exposure represents an established risk factor for PD occurrence, and both PD and Mn-intoxicated patients display a characteristic extrapyramidal syndrome primarily involving dopaminergic (DAergic) neurodegeneration with shared common molecular mechanisms.', 'To better understand the specificity of DAergic neurodegeneration, we studied Mn toxicity in vivo in Caenorhabditis elegans.', 'Combining genetics and biochemical assays, we established that extracellular, and not intracellular, dopamine (DA) is responsible for Mn-induced DAergic neurodegeneration and that this process (1) requires functional DA-reuptake transporter (DAT-1) and (2) is associated with oxidative stress and lifespan reduction.'], ['Multiple system atrophy (MSA) is a neurodegenerative disorder that occurs sporadically and causes parkinsonism, cerebellar, autonomic, urinary, and pyramidal dysfunction in many combinations.'], ['BACKGROUND: Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease.'], ['METHODS: The analytical sample included 8,383 adults aged >=65-years without history of stroke, cancers, neurological conditions, or brain damage who participated in at least one-wave of the 2010-2016 waves of the Health and Retirement Study.'], ['One of the potential long-term outcomes that we speculate is the development of neurodegenerative diseases as a long-term consequence of SARS-CoV-2 especially in people that have developed severe neurological symptoms.', 'Severe inflammatory reactions and aging are two very strong common links between neurodegenerative diseases and COVID-19.', "We hypothesize that people with neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and aged people are at higher risk of getting the COVID-19 than normal adults.", 'This could then suggest a direct relationship between neurodegenerative diseases, ACE-2 expression, and the susceptibility to COVID-19.'], ['Acid sphingomyelinase deficiency (ASMD) leads to cellular accumulation of sphingomyelin (SM), neurodegeneration, and early death.', 'Oral treatment of ASM-KO mice with a FAAH inhibitor prevented SM buildup; alleviated inflammation, neurodegeneration, and behavioral alterations; and extended lifespan.'], ['This minimally invasive stem cell approach can confer major advantages in the context of cell-mediated therapy for patients with neurodegenerative diseases.'], ["Alzheimer's disease (AD) is the most common progressive neurodegenerative disease.", 'The AD brain is marked by severe neurodegeneration like the loss of synapses and neurons, atrophy and depletion of neurotransmitter systems in the hippocampus and cerebral cortex.'], ['However, many treatment needs remain unsatisfied: tumoral pathologies, AIDS, neurodegenerative diseases, psychiatric pathologies and rare diseases are only a few of the challenges facing research in its attempt to make new and effective therapies available.'], ['Finally, UA has protective effects against several neurodegenerative diseases, suggesting it could have interesting actions on neuronal development and function.'], ["Alzheimer's disease is a neurodegenerative disease with a huge impact on people's quality of life, life expectancy, and morbidity."], ['DESIGN: Participants were 101 older adults with amnestic MCI (M = 71 years, 45% females) in the Canadian Consortium on Neurodegeneration in Aging (CCNA) COMPASS-ND study.'], ["With modern population growth and an increase in the average lifespan, more patients are becoming afflicted with neurodegenerative diseases such as dementia and Alzheimer's.", "Patients with a history of epilepsy, drug abuse, and mental health disorders such as depression have a larger risk of developing Alzheimer's and other neurodegenerative diseases later in life."], ['The role of the accumulation of carbonylated proteins in the progression of several diseases has also been reported in the literature, such as neurodegenerative diseases, diabetes, obesity, aging, and cancer.'], ['Among participants with neuroimaging, participants with RA (n = 33) and without RA (n = 98) had similar amyloid burden and neurodegeneration measures, including regions sensitive to aging and dementia, but greater mean white matter hyperintensity volume relative to the total intracranial volume (mean (SD)% : 1.12 (0.57)% versus 0.76 (0.69)% of TIV, p = 0.01), and had higher mean (SD) number of cortical infarctions (0.24 (0.44) versus 0.05 (0.33), p = 0.02).'], ["Since age is the main risk factor for neurodegenerative diseases, it is reasonable to argue that cellular senescence might play a major role in Alzheimer's disease."], ['The increase in life expectancy of the world population is associated with a higher prevalence of neurodegenerative diseases.', "Alzheimer's Disease (AD) is the most common neurodegenerative disease, affecting currently 43 million people over the world."], ['LOAD is a progressive neurodegenerative disorder that involves the accumulation of beta-amyloid (Abeta) plaques and neurofibrillary tangles in the brains of elderly patients.'], ["Such approaches already are used in the study of Alzheimer's disease (AD), a progressive neurodegenerative disorder that, with the overall increase in life expectancy, will affect an increasing proportion of the population and become an increasingly serious public health concern."], ['Coronary artery disease, autoimmune disorders such as systemic lupus erythematosus or rheumatoid arthritis, history of acute or chronic infectious or hypersensitivity myocarditis, infiltrative processes, hypothyroidism, congenital cardiopathies such as left ventricular noncompaction or Ebstein anomaly, lamin A/C mutations, and pathologic hypervagotony and idiopathic degenerative scleroatrophy of the atrioventricular junctional specialized tissue (Lenegre-Lev disease) are among the most frequent etiologies of complete atrioventricular block in young or middle-aged adults.'], ['Also, due to increasing life expectancy, the number of elderly patients with osteoporosis affected by degenerative and traumatic spinal diseases will increase further.'], ['Conversely, ample evidence that either pharmacological inhibition or activation of sirtuin isoforms is potentially beneficial in study models of cancer and neurodegenerative diseases have been obtained.'], ['BACKGROUND: Amyotrophic lateral sclerosis (ALS) is a progressive, lethal, neurodegenerative disease, currently without any effective therapy.'], ['Neurodegenerative diseases are becoming increasingly common as life expectancy increases.', 'Can model organisms such as Drosophila speed the process of finding cures and treatments for human neurodegenerative diseases?', "Here we focus on the use of Drosophila to identify potential treatments for neurodegenerative diseases such as Huntington's and we discuss how well these therapies translate into mammalian systems."], ["Degenerative neurologic disorders such as Parkinson's disease are becoming more prevalent as life expectancy is improved."], ['Glutamate excitotoxicity is partly responsible for cerebral traumas evoked by ischemia and has been implicated in several neurodegenerative diseases including amyotrophic lateral sclerosis (ALS).', 'This suggests that the dEAAT1-deficient fly provides a powerful genetic model system for molecular analysis of glutamate-mediated neurodegeneration.'], ['Few studies have investigated autobiographical amnesia in neurodegenerative diseases and yet these pathologies are particularly relevant when addressing the issue of theories of long-term memory consolidation.', "In order to test these models, we studied three groups of patients with a neurodegenerative disease predominantly affecting different cerebral structures namely the MTL (13 patients in the early stages of Alzheimer's disease) and the neocortex involving either the anterior temporal lobe (10 patients with semantic dementia) or the frontal lobe (15 patients with the frontal variant of frontotemporal dementia, fv-FTD)."], ['Between 1983 and 1992, one surgeon at Wheeling Hospital in Wheeling, W.Va., performed 121 primary cruciate-sparing total knee arthroplasties on patients with degenerative joint disease.'], ['BACKGROUND: Sex is a significant risk factor in many neurodegenerative disorders.'], ['Among these disorders, neurodegenerative diseases have a significant impact.'], ["According to the literature review, most of the techniques predicted higher accuracy (more than 90%), which is beneficial for assessing and screening neurodegenerative illness, particularly Alzheimer's disease."], ["Neurodegeneration is the destruction of neurons, and once the neurons degenerate they can't revive.", 'This is one of the most concerned health conditions among aged population, more than ~70% of the elderly people are suffering from neurodegeneration.', "Among all of the neurodegenerative diseases, Alzheimer's disease (AD), Parkinson's disease (PD) and Poly-glutamine disease (Poly-Q) are the major one and affecting most of the people around the world and posing excessive burden on the society.", 'Drosophila melanogaster is one of the best animal proven by several eminent scientist and had received several Nobel prizes for uncovering mechanism of human related genes and highly efficient model for studying neurodegenerative diseases due to its great affinity with human disease-related genes.', 'In this review, we are dealing with various types of such nutraceuticals which have potent value in the prevention and curing of the diseases related to neurodegeneration.HighlightsNeurodegeneration is the silently progressing disease which shows its symptoms when it is well rooted.Many chemical drugs (almost all) have only symptomatic relief with side effects.Potent mechanism of neurodegeneration and improvement effect by nutraceuticals is proposed.Based on the Indian Cuisine scientists are trying to find the medicine from the food or food components having antioxidant properties.The best model to study the neurodegenerative diseases is Drosophila melanogaster.Many nutraceuticals having antioxidant properties have been studied and attenuated various diseases are discussed.'], ['Proteinopathy in neurodegenerative diseases is typically characterized by deteriorating activity of specific protein aggregates.'], ['BACKGROUND: Ataxia telangiectasia (A-T) is a neurodegenerative disorder.'], ['The clinical spectrum of NPC disease ranges from a neonatal rapidly progressive fatal disorder to an adult-onset chronic neurodegenerative disease.'], ["Alzheimer's disease (AD) represents the most common neurodegenerative disorder."], ['Hereditary spastic paraplegias (HSPs) are a group of neurodegenerative disorders characterized by degeneration of the longest motor neurons in the corticospinal tract, leading to muscle weakness and spasticity of the lower limbs.'], ['Given that both spontaneous and engineered sheep models of human neurodegenerative diseases already exist, sheep constitute a powerful species in which longitudinal in vivo studies can be conducted.'], ["Alzheimer's disease (AD) is a neurodegenerative disorder that is increasing worldwide due to increased life expectancy."], ['WS is a progressive neurodegenerative disorder, which will probably help us in understanding the positive impact of continuous subcutaneous insulin infusion in prolonging the life span and retarding neuronal damage in WS.'], ['SUMMARY OF THE FINDINGS: SMA is a neurodegenerative disorder with autosomal recessive genetic heredity.'], ['Based on our recent observations, we discuss a possible mechanism for mitochondrial dysfunction resulting in the excessive production of reactive oxygen species, and a role for the hyperoxidative stress status in neurodegeneration in SAMP mice.'], ['BASIC PATHOLOGIES: In the recent years, remarkable progress has been made concerning the identification of molecular mechanisms underlying the pathology of neurodegenerative disorders.', 'Growing evidence indicates that a common basis of many neurodegenerative dementias can be found in increased production, misfolding and pathological aggregation of proteins, such as beta-amyloid, tau protein, a-synuclein, or the recently described ubiquitinated TDP-43.'], ['We examine the allometric (comparative scaling) relationships between rates of neurodegeneration resulting from equivalent mutations in a diverse group of genes from five mammalian species with different maximum lifespan potentials.', 'In both retina and brain, rates of neurodegeneration vary by as much as two orders of magnitude and are strongly correlated with maximum lifespan potential and rates of formation of mitochondrial reactive oxygen and nitrogen species (RONS).', 'This provides a new and unifying framework for investigating neurodegenerative disorders.'], ['Neurodegenerative diseases (NDs) are some of the most important health challenges modern medicine and advanced societies face.'], ['Defects in PQC functions are linked to various human diseases including many aging-associated neurodegenerative diseases.'], ['Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by the selective and progressive loss of motor neurons from the spinal cord, brain stem, and motor cortex.'], ['The steady increase in life-expectancy of world population, coupled to many genetic and environmental factors (for instance, pre- and post-natal exposures to environmental neurotoxins), predispose to the onset of neurodegenerative diseases, whose prevalence is expected to increase dramatically in the next years.', "Recent studies have proposed links between the gut microbiota and neurodegenerative disorders such as Alzheimer's and Parkinson's diseases.", 'Several microbial-derived neurochemicals involved in the gut-microbiota-brain crosstalk seem implicated in the biological and physiological basis of neurodevelopment and neurodegeneration.', 'New technologies are recently born to help understanding the causative role of gut microbes in neurodegeneration.', 'This review aims to make an overview of recent advances in the study of the microbiota-gut-brain axis in the field of neurodegenerative disorders by: (a) identifying specific microbial pathological signaling pathways; (b) characterizing new, advanced engineered tools to study the interactions between human cells and gut bacteria.'], ['In contrast, the oldest age group were more likely to have severe physical health problems, such as cancer, chronic non-cancer pain, neurological conditions and significant cardiopulmonary morbidity.'], ['Selenocysteine can also prevent cancer, neurodegenerative diseases and cardiovascular diseases.'], ['In addition to reviewing recent studies of hydralazine efficacy in animal SCI and ALD models, the Commentary reviews new insights concerning novel lifespan- and healthspan-extending properties of hydralazine obtained during studies in model invertebrate organisms, since the mechanisms involved seem of likely benefit during the treatment of degenerative disease.'], ["The expansion of trinucleotide CAG repeats causes hereditary adult-onset neurodegenerative disorders, such as Huntington's disease, dentatorubral-pallidoluysian atrophy, spinobulbar muscular atrophy and multiple forms of spinocerebellar ataxia (SCA).", 'We generated transgenic Caenorhabditiselegans strains expressing human ATXN3 genes in motoneurons, and animals expressing mutant ATXN3-CAG89 alleles showed decreased lifespan, impaired movement, and rates of neurodegeneration greater than wild-type ATXN3-CAG10 controls.', 'Using these models, we discovered that chemical modulation of the UPRER reduced neurodegeneration and warrants investigation in mammalian models of MJD.'], ["Age-associated neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and the polyglutamine (polyQ) diseases, are becoming prevalent as a consequence of elongation of the human lifespan.", 'Pathological examinations revealed neurodegeneration and intranuclear polyQ protein inclusions accompanied by gliosis, which recapitulate the neuropathological features of polyQ disease patients.', 'Because the accumulation of abnormal proteins is a shared pathomechanism among various neurodegenerative diseases, we suggest that this new marmoset model will contribute toward elucidating the pathomechanisms of and developing clinically applicable therapies for neurodegenerative diseases.'], ['Transactive response DNA-binding protein 43 kDa (TDP-43, also known as TBPH in Drosophila melanogaster and TARDBP in mammals) is the main protein component of the pathological inclusions observed in neurons of patients affected by different neurodegenerative disorders, including amyotrophic lateral sclerosis (ALS) and fronto-temporal lobar degeneration (FTLD).', 'The number of studies investigating the molecular mechanisms underlying neurodegeneration is constantly growing; however, the role played by TDP-43 in disease onset and progression is still unclear.', 'This novel Drosophila model exhibits an evident degenerative phenotype with reduced lifespan and early locomotion defects.', 'Additionally, we show that important proteins involved in neuromuscular junction function, such as syntaxin (SYX), decrease their levels as a consequence of TDP-43 loss of function implying that the degenerative phenotype is a consequence of TDP-43 sequestration into the aggregates.', 'Our data lend further support to the role of TDP-43 loss-of-function in the pathogenesis of neurodegenerative disorders.', 'The novel transgenic Drosophila model presented in this study will help to gain further insight into the molecular mechanisms underlying neurodegeneration and will provide a valuable system to test potential therapeutic agents to counteract disease.'], ['Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease primarily affecting motor neurons in the central nervous system.'], ['The survival and life expectancy rates of people with traumatic and degenerative neurological conditions are increasing, sometimes up to several decades.'], ['We use large samples of longitudinally followed populations from the Framingham Heart Study (FHS) original and offspring cohorts and the Long Life Family Study (LLFS) to investigate gender-specific effects of the ApoE4 allele on human survival in a wide range of ages from midlife to extreme old ages, and the sensitivity of these effects to cardiovascular disease (CVD), cancer, and neurodegenerative disorders (ND).', 'Major human diseases including CVD, ND, and cancer, whose risks can be sensitive to the e4 allele, do not mediate the association of this allele with lifespan in large FHS samples.'], ['Dysfunction of two structurally and functionally related proteins, FUS and TAR DNA-binding protein of 43 kDa (TDP-43), implicated in crucial steps of cellular RNA metabolism can cause amyotrophic lateral sclerosis (ALS) and certain other neurodegenerative diseases.'], ['Neurological deterioration occurred in 14%.'], ['Wolfram syndrome is a rare, autosomal recessive, neurodegenerative disorder presenting with the main clinical symptoms of childhood-onset diabetes mellitus, optic atrophy, diabetes insipidus and deafness (DIDMOAD).'], ['It is associated with increased incidences of seizures, sleep disorders, neurodegenerative diseases, neuroendocrine dysregulation, and psychiatric diseases, as well as non-neurological disorders such as sexual dysfunction, bladder and bowel incontinence, and systemic metabolic dysregulation that may arise and/or persist for months to years post-injury.'], ["The increasing life expectancy in our society results in a continuously growing number of patients suffering from neurodegenerative disorders, particularly Alzheimer's disease (AD).", 'Increased production of specific proteins and their pathologic aggregation in the brain appears to be a pathomechanism which occurs early in the course of many different neurodegenerative diseases.', 'This type of "in vivo histopathology" approach allows the characterization of neurodegenerative disorders on the basis of the underlying pathology rather than on their symptomatic appearance.'], ['Since glutamate toxicity has been proposed as a mechanism for the degeneration of motor neurons in a variety of neurodegenerative diseases, we tested the effects of MSO on the transgenic mouse that overexpresses the mutant human SOD1(G93A) gene, an animal model for the primary inherited form of the human neurodegenerative disease amyotrophic lateral sclerosis (ALS).', 'These results show that in the SOD1(G93A) model of neurodegenerative diseases, the concentration of brain glutamate (determined with (1)H-MRS) can be lowered by inhibiting in vivo the synthesis of glutamine with non-toxic doses of MSO.'], ["Huntington's disease is an autosomal dominant neurodegenerative disorder caused by expansion of a polyglutamine tract in the huntingtin protein that results in intracellular aggregate formation and neurodegeneration.", "Our findings indicate that nonnuclear events induced by cytoplasmic huntingtin aggregation play a central role in the progressive neurodegeneration observed in Huntington's disease."], ['We define persistent vegetative state as a vegetative state present one month after acute traumatic or nontraumatic brain injury or lasting for at least one month in patients with degenerative or metabolic disorders or developmental malformations.', 'Three categories of disorder can cause such a state: acute traumatic and non-traumatic brain injuries; degenerative and metabolic brain disorders, and severe congenital malformations of the nervous system.', 'Patients with degenerative or metabolic disorders or congenital malformations who remain in a persistent vegetative state for several months are unlikely to recover consciousness.'], ["BACKGROUND: Alzheimer's disease (AD) is a progressive neurodegenerative disease that compromises the cognitive system and causes dementia."], ['A healthy neonatal majority present at older ages with sequelae such as developmental disorders, epilepsy, mental health diseases, tumors, and neurodegenerative disease, often during the first 1000 days.'], ['CONCLUSIONS: This work introduces and mechanistically characterizes a new biologic for treating ALS and other complex neurodegenerative diseases.'], ['Neurodegenerative diseases affect over 30 million people worldwide with an ascending trend.', 'Although the pathophysiology of such diseases is partially known, it remains unclear upon which point a disease turns degenerative.', 'For many neurodegenerative diseases the involvement of G protein-coupled receptors (GPCRs), which are key players of neuronal transmission and plasticity, has become clearer and holds great promise in elucidating their biological mechanism.', 'Additionally, the examples discussed here were shown to display relevant alterations in brain signalling and have already been associated with the pathophysiology of certain neurodegenerative diseases.'], ['INTRODUCTION: Intellectual disability, accelerated aging, and early-onset Alzheimer-like neurodegeneration are key brain pathological features of Down syndrome (DS).'], ["This narrative review examines the preclinical and clinical literature of SAMe's metabolism and alterations seen in disease states such as depressive disorders, pain disorders, fatigue, cognition, dementia, use in pregnancy and peripartum, children, adolescents, and adults, to the elderly with and without dementia, stroke, and neurodegeneration, in order to highlight its potential benefit in post-concussive sequelae after TBI."], ['Normal pressure hydrocephalus (NPH) is an important differential diagnosis of neurodegenerative diseases.'], ['Ataxia-telangiectasia (A-T), an autosomal recessive disease caused by mutations in the ATM gene is characterised by cerebellar atrophy and progressive neurodegeneration which has been poorly recapitulated in Atm mutant mice.', 'Consequently, pathways leading to neurodegeneration in A-T are poorly understood.', 'Thus the rat model represents a suitable one for studying neurodegeneration in A-T and adds support for the use of anti-inflammatory drugs for the treatment of neurodegeneration in A-T patients.'], ['About 25% of patients develop a progressive neurodegeneration.'], ['Arimoclomol has been found to be neuroprotective in a number of neurodegenerative disease models, including Amyotrophic Lateral Sclerosis (ALS), and in mutant Superoxide Dismutase 1 (SOD1) mice that model ALS, Arimoclomol rescues motor neurons, improves neuromuscular function and extends lifespan.', 'For example, protein aggregation is a characteristic pathological feature of neurodegenerative diseases including ALS.', 'Therefore, by targeting multiple pathological mechanisms, compounds such as Arimoclomol may be particularly effective in the development of a disease-modifying therapy for ALS and other neurodegenerative disorders.'], ['Importantly, Abeta42 fibril deposits as well as its SDS-soluble form were dramatically reduced upon dZip1 inhibition, resulting in less neurodegeneration, significantly improved cognitive performance, and prolonged lifespan of the Abeta42-transgenic flies.'], ['The increased life expectancy in industrialised countries in the last half century has also brought to a greater incidence of neurological disorders, including neurodegenerative diseases and developing in a rather long time.', "However, partial reproduction of neuropathology and/or cognitive deficits of Alzheimer's disease (AD), vascular dementia and dementia occurring in Huntington's and Parkinson's diseases, or in other neurodegenerative disorders may represent a basis for understanding pathophysiological traits of these diseases and for contributing to their treatments."], ['Intracellular accumulations of filamentous tau inclusions are neuropathological hallmarks of neurodegenerative diseases known as tauopathies.', 'The discovery of multiple pathogenic tau gene mutations in many kindreds with familial frontotemporal dementia with parkinsonism linked to chromosome 17 (FTDP-17) unequivocally confirmed the central role of tau abnormalities in the etiology of neurodegenerative disorders.', 'Furthermore, RW but not hWT mice demonstrated neurodegeneration and a reduced lifespan.'], ['Neurodegenerative diseases, such as Alzheimer disease (AD), Parkinson disease (PD), supranuclear palsy and Huntington disease (HD), are characterized in part by aberrant cerebral TGase activity and by increased cross-linked proteins in affected brain.', 'In support of the hypothesis that TGases contribute to neurodegenerative disease, a recent study shows that knocking out TGase 2 in HD-transgenic mice results in increased lifespan.', 'In neurodegenerative diseases, the brain is under oxidative stress and cystamine can theoretically be converted to the potent antioxidant cysteamine in vivo.', 'In addition to neurodegenerative diseases, aberrant TGase activity is associated with celiac disease.', 'This review focuses on the strategies that have been recently employed in the design of TGase inhibitors, and on the possible therapeutic benefits of selective TGase inhibitors to patients with neurodegenerative disorders or to patients with celiac disease.'], ["Parkinson's disease (PD) is a common neurodegenerative disease characterized by tremor, rigidity, bradykinesia, and loss of postural reflexes."], ['These exciting data, if confirmed in other long-term clinical trials, may herald a neuroprotective approach to the treatment of this degenerative disease.'], ['INTRODUCTION: White matter hyperintensities (WMHs) are common magnetic resonance imaging (MRI) findings in the aging population in general, as well as in patients with neurodegenerative diseases.', 'However, it is not well-understood whether there are disease-specific differences in prevalence and distribution of WMHs in different neurodegenerative disorders.', "METHODS: Data included 976 participants with cross-sectional T1-weighted and fluid attenuated inversion recovery (FLAIR) MRIs from the Comprehensive Assessment of Neurodegeneration and Dementia (COMPASS-ND) cohort of the Canadian Consortium on Neurodegeneration in Aging (CCNA) with eleven distinct diagnostic groups: cognitively intact elderly (CIE), subjective cognitive impairment (SCI), mild cognitive impairment (MCI), vascular MCI (V-MCI), Alzheimer's dementia (AD), vascular AD (V-AD), frontotemporal dementia (FTD), Lewy body dementia (LBD), cognitively intact elderly with Parkinson's disease (PD-CIE), cognitively impaired Parkinson's disease (PD-CI), and mixed dementias.", 'WMH burden was significantly greater in all neurodegenerative dementia groups, likely encompassing areas exclusively impacted by neurodegeneration as well as areas related to cerebrovascular disease pathology.'], ['Deposition of misfolded protein aggregates in key areas of human brain is the quintessential trait of various pertinent neurodegenerative disorders including amyotrophic lateral sclerosis (ALS).'], ["Alzheimer's disease (AD) and Parkinson's disease (PD) are the most common age-related neurodegenerative disorders, affecting several millions of aged people globally.", 'Oxidative stress-induced glial cells activation, neuroinflammation and mitochondrial dysfunction lead to various molecular events in brain neurons causing neuronal cell death in these neurodegenerative disorders.', 'Currently used drugs for treatment of AD and PD only reduce the symptoms of these diseases, but unable to stop the process of neurodegeneration.'], ['Drosophila is an ideal model organism for studying a progressive age-related neurodegenerative disease such as AD since its neuronal organizations and functioning are highly similar to that of humans.'], ['Amyotrophic Lateral Sclerosis (ALS) is a fatal, late-onset, progressive motor neurodegenerative disorder.'], ["Parkinson's disease (PD) is an age-related neurodegenerative disorder characterized by progressive deterioration of motor function and loss of dopaminergic neurons in the substantia nigra."], ['Tauopathies are a family of neurodegenerative diseases characterized by the presence of abnormally hyperphosphorylated Tau protein.'], ['FC, as measured here, might be valuable for early identification of this neurodegeneration.'], ['The hippocampus is particularly susceptible to neurodegeneration.'], ["Huntington's disease (HD) is a fatal, neurodegenerative disorder in which patients suffer from mobility, psychological and cognitive impairments."], ['Similar to SCA17 patients, transgenic flies expressing a mutant hTBP protein with an expanded polyQ tract (hTBP80Q) exhibit progressive neurodegeneration, late-onset locomotor impairment and shortened lifespan.'], ["Abnormal tau build-up is a hallmark of Alzheimer's disease (AD) and more than 20 other serious neurodegenerative diseases."], ["Huntington's disease (HD) is one of the human neurodegenerative diseases for which there is no effective treatment."], ['Although the Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) diet was associated with better cognitive function and lower risk of cognitive impairment, it could not be applied to older Chinese due to the traditional dietary characteristics in China.'], ["Alzheimer's disease(AD) is an age-associated neurodegenerative disease that results in deterioration of memory and cognitive function."], ['Increases in human life expectancy have led to increases in the prevalence of senile dementia and neurodegenerative diseases.', 'Further research is warranted to explore the potential therapeutic and prophylactic utility of sulforaphane for improving learning and memory, especially in those suffering from neurodegenerative disorders.'], ["Parkinson's disease (PD) is one of the most common neurodegenerative disorders that manifest various motor and nonmotor symptoms."], ['INTRODUCTION: Age related neurodegenerative disorders affect millions of people around the world.', 'The role of the gut microbiome (GM) in neurodegenerative disorders has been elucidated over the past few years.', 'Dysbiosis of the gut microbiome ultimately results in neurodegeneration.', "AREAS COVERED: This review is focused on demonstrating the role of the gut microbiome in host physiology in Parkinson's disease (PD) and other neurodegenerative disorders.", "We will discuss how the microbiome will impact neurodegeneration in PD, Alzheimer's Disease (AD), Multiple sclerosis (MS), Amyotrophic Lateral Sclerosis (ALS), and finally discuss how the gut microbiome can be influenced through diet and lifestyle.", 'EXPERT OPINION: Currently, much of the focus has been to study the mechanisms by which the microbiome induces neuroinflammation and neurodegeneration in PD, AD, MS, ALS.', 'Polyphenol prebiotics delivered in combination with probiotics (synbiotics) present an exciting new avenue to harness the microbiome to attenuate immune inflammatory responses which ultimately may influence brain cascades associated with promotion of neurodegeneration across the lifespan.'], ['Prognosis is poor, death occurs at the median age of 39 years with a major cause represented by respiratory failure as a consequence of brain stem atrophy and neurodegeneration.', 'Evidence indicates that specific metabolic diseases (type 1 and type 2 diabetes), neurodegenerative diseases, atherosclerosis, inflammatory pathologies and also cancer are closely related to ER dysfunction.'], ['BACKGROUND: Niemann-Pick disease, type C1 (NPC1) is a lysosomal storage disorder characterised by progressive neurodegeneration.'], ['Here, we have shown that mouse prion disease shows many of the hallmarks of human AD, including progressive terminal neurodegeneration and memory deficits due to a disruption of hippocampal cholinergic innervation.'], ["Changes in emotional/behavioral functioning in adulthood are typically associated with neurodegeneration and individuals with DS are higher risk for dementia of the Alzheimer's type."], ['Although the contribution of neuronal tau to behavioral changes and neuronal loss in neurodegenerative diseases has been studied extensively, the functional consequences of tau deposition in glial cells have been less well characterized.'], ['Proximal spinal muscular atrophy (SMA) is a neurodegenerative disease caused by low levels of the survival motor neuron (SMN) protein.'], ['Amyotrophic lateral sclerosis (ALS) is a devastating and fatal neurodegenerative disease of adults which preferentially attacks the neuromotor system.'], ['An increasing number of neurodegenerative diseases are being linked to mutations in genes encoding proteins required for axonal transport and intracellular trafficking.', 'Together, these data suggest that mutant p150(Glued) causes neurodegeneration in the absence of significant changes in axonal transport, and therefore other functions of dynein/dynactin, such as trafficking in the degradative pathway and stabilization of the NMJ are likely to be critical in maintaining the health of motor neurons.'], ['Ataxia telangiectasia is a rare, multiorgan neurodegenerative disorder with enhanced vulnerability to cancer and infection.'], ['We show that ClC-7 knockout mice additionally display neurodegeneration and severe lysosomal storage disease despite unchanged lysosomal pH in cultured neurons.', 'Such alterations were minor or absent in ClC-3 knockout mice, despite a massive neurodegeneration.'], ["Our knowledge of Parkinson's disease pathophysiology has greatly expanded during the last century, resulting in successful new medical and neurosurgical approaches toward this common neurodegenerative disorder."], ['CONCLUSION: These results suggest that hNT neuron transplantation may be a promising therapeutic strategy for ALS in the later phase of the neurodegeneration.'], ['Sex hormones including oestrogen, progesterone, testosterone and anti-Mullerian hormone are thought have neuroinflammatory effects and are implicated in both neuroprotection and neurodegeneration.'], ['Research on the microbiota of Drosophila has revealed new molecules that regulate the brain-gut axis, and it has been shown that dysbiosis of the fly microbiota worsens lifespan, motor function, and neurodegeneration in AD and PD models.'], ['It may be a suggestive sign of early neurodegeneration and may be a useful clinical tool to identify those at a higher risk of progressing to cognitive impairment.'], ['The purpose of the present study was to project the numbers of surgically treated degenerative spine disease (DSD) in Austria from 2017 until 2080 to provide potential future scenarios that the Austrian Health system might have to face.', 'Information on prevalence of surgically treated DSD was obtained from the Austrian Spine Register.', 'The total number of surgically treated DSD recorded in the Spine Register was 9300 and was estimated to be 9300/11200/13700 in 2080.', 'The number of subjects with surgically treated DSD were expected to increase in the age-strata (main scenario), 100% corresponds to the number in each age and gender stratum: 0-40 years by (male/female) 2%/2%, 40-50years -7%/-7%, 50-59years -11%/-9%, 60-69years 21%/16%, 70-79years 51%/31%, 80-89years 211%/129% and 90+years 698%/411%.', 'CONCLUSIONS: Total numbers of subjects with DSD in Austria will increase from 2017 to 2080.'], ['BACKGROUND: Cognitive impairment is a distinguishing feature of many neurodegenerative diseases.', 'NEW METHOD: The ability to perform executive tasks coupled with a long lifespan makes sheep (Ovis aries) an ideal species for modelling cognitive decline in progressive neurodegenerative conditions.'], ['NCLs are distinct lysosomal storage disorders (LSDs) sharing various hallmarks, namely accumulation of protein aggregates and ceroid lipofuscin leading to neurodegeneration and blindness.'], ['The pathogenic basis behind most neurodegenerative diseases is that the disruption of protein homeostasis (i.e.', 'Misfolded proteins often aggregate and accumulate to trigger neurotoxicity through cellular stress pathways and consequently cause neurodegenerative diseases.', 'Neurodegenerative diseases are age-associated, and their incidence is expected to rise as humans continue to live longer and pursue a greater life expectancy.', "We presently review the sequelae of protein misfolding and aggregation, as well as the role of these phenomena in several neurodegenerative diseases including Alzheimer's disease, Huntington's disease, amyotrophic lateral sclerosis, Parkinson's disease, transmissible spongiform encephalopathies, and spinocerebellar ataxia."], ['Total knee arthroplasty is a well established treatment for degenerative joint disease, which is also performed as a treatment in younger and middle-aged patients who have a significant physical activity and high life expectancy.'], ['Degenerative joint disease is a common age-associated illness that causes pain and thus, in persons with SCI above the T6 level, can serve as a noxious stimulus to trigger autonomic dysreflexia (AD).'], ['The rise in the prevalence of neurodegenerative diseases parallels the rapid increase in human lifespan.'], ["Huntington's disease (HD) is a devastating neurodegenerative disorder which is inherited in an autosomal dominant manner.", 'Furthermore, we found that increasing dosage of Glut1-the Drosophila melanogaster homologue of this glucose transporter-ameliorated HD-relevant phenotypes in fruit flies, including neurodegeneration and life expectancy.'], ['The detrimental consequences of vitamin D dietary deficiency have been documented in other neurodegenerative diseases.'], ["Classical neurodegenerative diseases such as Alzheimer's, Parkinson's, and Huntington's are most commonly seen in older persons.", 'Even though neuronal loss, neuronal death and accumulated toxic proteins are well investigated, the mechanism(s) of neurodegenerative disorders is not yet fully understood.', 'We propose that the patterns of versican V1 and V2 isoforms act as a fine-tuned mechanism for guiding the change of neural microenvironment, and the unbalanced expression of V1 and V2 isoforms may contribute to the pathogenesis of neurodegenerative diseases.'], ['BACKGROUND AIMS: Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder characterized by the loss of brain and spinal cord motor neurons (MN).'], ['Here we show that overexpressing any of three histone deacetylases (HDACs 3, 6, or 11) suppresses CGG repeat-induced neurodegeneration in a Drosophila model of FXTAS.'], ['Activation of neuronal CB(1) cannabinoid receptors attenuates excitotoxic glutamatergic neurotransmission, triggers prosurvival signalling pathways and palliates motor symptoms in animal models of neurodegenerative disorders.', "These findings support a pivotal role for CB(2) receptors in attenuating microglial activation and preventing neurodegeneration that may pave the way to new therapeutic strategies for neuroprotection in Huntington's disease as well as in other neurodegenerative disorders with a significant excitotoxic component."], ['These mechanisms are involved in the pathogenesis of several neurodegenerative disorders.', 'The major target for tetracyclines in neurodegeneration could lie within the complex network that links mitochondria, oxidative stress, poly (ADP-ribose) polymerase-1 and apoptosis.', 'Here, we review the neuroprotective effects of tetracyclines in animal models and in human disease, and we focus on their possible mechanism(s) of action, with special regard to mitochondrial dysfunction in neurodegeneration.'], ['Spinocerebellar ataxia 7 (SCA7) is a neurodegenerative disease caused by a polyglutamine (polyQ) expansion in the ataxin 7 (ATXN7) protein, a member of a multiprotein complex involved in histone acetylation.'], ['Neural tissue grafting can be highly effective and constitutes a potentially curative approach for progressive neurodegenerative disorders such as PD.'], ['Age-related hearing loss, or presbyacusis, is a common degenerative disorder affecting communication and quality of life for millions of older adults.', 'Importantly, novel new imaging methods described here now provide a means to analyze human temporal bones in a way that had not previously been feasible and thereby represent a significant new tool for otopathological evaluation.SIGNIFICANCE STATEMENT:Age-related hearing loss is a common neurodegenerative disorder affecting communication and quality of life.'], ["Friedreich's ataxia (FA) is a devastating, multi-systemic neurodegenerative disease affecting thousands of people worldwide."], ['Therefore, given the sexual steroids fluctuations throughout the entire female lifespan, and considering the role played by sex hormones at the central level, it is not surprising to observe the onset of mood or neurodegenerative disorders over time.'], ['Over the last three decades, neurodegenerative diseases have received increasing attention due to their frequency in the aging population and the social and economic burdens they are posing.', 'In turn, gut microbiota dysbiosis is emerging as a novel player in the pathogenesis of neurodegenerative diseases.', 'This review aims at addressing one of the emerging aspects of neuroscience, particularly the interplay between food bioactive derivatives and neurodegeneration.', 'We will specifically address the role that polyphenols and omega-3 fatty acids play in preventing neurodegenerative diseases and how dietary intervention complements available pharmacological approaches.'], ['This may pave the way for the rational design of drugs to treat humnan neurodegenerative disorders in the future.'], ['OXPHOS dysfunction is associated with a plethora of diseases ranging from rare inherited disorders to common conditions including diabetes, cancer, neurodegenerative diseases, as well as aging.'], ["Among others, Parkinson's disease (PD) has received special attention in that it is a severe and progressive neuro-degenerative disease."], ['Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder, with a 10% genetic linkage, of which 20% of these cases may be attributed to mutations in superoxide dismutase (SOD1).'], ['Muscular dystrophies (MDs) are degenerative diseases which may led to marked functional impairment and reduced life expectancy.'], ["Huntington's disease (HD) is a lethal, autosomal dominant neurodegenerative disorder caused by CAG repeat expansions at exon 1 of the huntingtin (Htt) gene, which encodes for a mutant huntingtin protein (mHtt)."], ["Parkinson's disease (PD), the second most common neurodegenerative disease, impairs motor skills and cognitive function."], ['Amyotrophic lateral sclerosis (ALS) is a progressive fatal neurodegenerative disease characterised by loss of motor neurons that currently has no cure.'], ["This translates into a dramatic increase in disease burden of elderly patients suffering from senile disorders including neurodegenerative diseases, particularly Alzheimer's disease (AD)."], ['As a microscopic but multicellular and genetically tractable animal with a well-defined nervous system and an experimentally tenable lifespan, C. elegans affords significant advantages to researchers attempting to determine causative and therapeutic factors that influence neuronal dysfunction and age-associated neurodegeneration.'], ['In considering the overall causes of death among the Thai population, the leading causes are diet-related chronic degenerative diseases.'], ['PATIENT SAMPLE: All patients between 18 and 40 years of age at the time of the surgery who underwent ACDF due to degenerative cervical disease at Helsinki University Hospital between the years 1990 and 2005 who had filled in the quality of life questionnaires 12 to 28 years after the surgery (281 patients), and a propensity matched control cohort of the general population selected based on age, sex, and smoking status.', 'METHODS: The medical records of all patients who underwent ACDF due to degenerative cervical disease at the age of 18 to 40 years at Helsinki University Hospital between 1990 and 2005 were analyzed retrospectively.'], ['(4) Genetic polymorphisms that reduced expression of MYT1L in the hippocampus resulted in increased expression of ID1 and ID3, decreased levels of the proneural basic HLH (bHLH) transcriptional regulators TCF4 and NEUROD6 and decreased expression of genes involved in long-term potentiation and synaptic transmission, cancer and neurodegeneration.'], ['The 20th century has been characterized by a fantastic advance in life expectancy and by a shift from infectious to chronic degenerative diseases as prevailing causes of death.'], ['Women are therefore living an ever-increasing proportion of their lives in a hypoestrogenic, postmenopausal state, which could contribute to an increased risk of cognitive dysfunction and a variety of neurodegenerative diseases.'], ['Children in the VS and MCSs with acquired brain injury had lower mortality rates and those with degenerative diseases the highest mortality rates.'], ['Thus, leisure activities and having good cognitive reserve counteracting this neurodegeneration.'], ['Knee osteoarthritis (KOA) is a degenerative lower extremity disease that occurs most frequently in the elderly.'], ['Although astrocytosis is known to occur in neurodegenerative diseases, it is currently unknown how the severity of astrocytosis is correlated with the common combinations of pathologies in aging brains.'], ["BACKGROUND: We have proposed that cognitive resilience (CR) counteracts brain damage from Alzheimer's disease (AD) or AD-related dementias such that older individuals who harbor neurodegenerative disease burden sufficient to cause dementia remain cognitively normal."], ['Amyotrophic lateral sclerosis (ALS) is a complex and serious neurodegenerative disorder that develops in consequence of the progressive loss of the upper and lower motor neurons.', 'Numerous lines of evidence indicate that epigenetic changes are linked to aging, as well as neurodegenerative disorders, such as ALS.', 'Here, we provide a narrative review of the role of DNA methylation for this complex neurodegenerative disorder.'], ["Alzheimer's disease (AD) is a degenerative neurological condition that severely affects the elderly and is clinically recognised by a decrease in cognition and memory."], ["The prevalence of neurodegenerative disorders such as Alzheimer's and Parkinson's disease are rising globally.", 'The role of environmental pollution in neurodegeneration is largely unknown.', "Underlying molecular pathways of neurodegeneration are elucidated in pollutant-exposed C. elegans Alzheimer's or Parkinson's models by transcriptomics (RNA-seq), mass spectrometry-based proteomics and omics addressing other biochemical traits.", 'C. elegans models of neurodegenerative diseases are likewise well-suited for high throughput methods that provide a promising strategy to identify resilience pathways of neurosafety and keep up with the number of pollutants, nonchemical exposome factors, and their interactions.'], ["Alzheimer's disease is a devastating neurodegenerative disorder that poses a significant societal burden."], ['Autophagy dysfunction is associated with human diseases and conditions including neurodegenerative diseases, metabolic issues, and chronic infections.'], ['Neurodegenerative disorders are one of the significant challenges to the aging society, as per the United Nations, where 1 in 6 people globally over 65 years of age are expected to suffer by 2050.', 'Sensitive detection and effective monitoring of dopamine can help to diagnose these neurodegenerative disorders at a very early stage, which will help to properly treat these disorders and slow down their progression.', 'Therefore, the nano-bio-engineered biosensor platform being reported can determine deficient dopamine levels in a very selective and sensitive manner, which can help adequately manage neurodegenerative disorders, further slowing down the disease progression.'], ["People's social lives change as they age, and the nature of these changes differ based on whether people are on healthy aging trajectories or are experiencing neurodegenerative diseases that cause dementia, such as Alzheimer's disease and Parkinson's disease."], ["Paget's disease of bone (PDB) is a degenerative disorder affecting the skull and bones."], ['Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease affecting motor neurons.'], ['This commentary provides a novel synthesis of how biological systems adapt to a broad spectrum of environmental and age-related stresses that are underlying causes of numerous degenerative diseases and debilitating effects of aging.'], ['Sirtuin 2 (SIRT2) has been proposed to have a central role on aging, inflammation, cancer and neurodegenerative diseases; however, its specific function remains controversial.', "Recent studies propose SIRT2 pharmacological inhibition as a therapeutic strategy for several neurodegenerative diseases including Alzheimer's disease (AD).", 'These results suggest that, although SIRT2 pharmacological inhibition may have beneficial consequences in neurodegenerative diseases, its pharmacological inhibition at the periphery would not be recommended and the systemic adverse side effects should be considered.', 'This information is essential to maximize the therapeutic potential of SIRT2 inhibition not only for AD but also for other neurodegenerative diseases.'], ['Increasing evidence suggests that ROS may affect many pathological aspects of AD, including Abeta accumulation, tau hyperphosphorylation, synaptic plasticity, and mitochondrial dysfunction, which may collectively result in neurodegeneration in the brain.', 'Further investigation into the relationship between oxidative stress and AD may provide an avenue for effective preservation and pharmacological treatment of this neurodegenerative disease.', 'Since oxidative stress is common in the elderly and may contribute to the pathogenesis of AD, we also shed light on the role of antioxidant and inflammatory pathways in oxidative stress adaptation, which has a potential therapeutic target in neurodegenerative diseases.'], ['CONCLUSION: Elevated levels of IL-8 in older men may possibly be an early indicator of neurodegeneration that relates to PM performance.', 'Future studies should continue to examine PM and inflammation across genders to identify possible mechanisms through which these constructs may indicate neurodegeneration and dementia risk.'], ['Blood-brain barrier (BBB) function deteriorates during aging, contributing to cognitive impairment and neurodegeneration.'], ['However, non-genetic factors, including environmental elements, epigenetic changes, and lifestyle, have grabbed significant attention in recent years regarding the etiology of neurodegenerative diseases (NDD) and age-associated dementia.', 'When fully understood, these epigenetic landscapes could act as vital targets for pharmacogenetic rescue strategies for treating several diseases, including neurodegeneration- and age-induced dementia.', 'Keeping this objective in mind, this updated review summarises the epigenetic changes associated with age and neurodegeneration-associated dementia.'], ['However, the aging brain and subareas of the brain in patients with neurodegenerative disorders tend to accumulate glycogen, the cause and significance of which remain largely unexplored.'], ["As adults live longer with HIV, the neurocognitive burden of physiological and psychosocial stressors can impair everyday functioning and may contribute to the development of neurodegenerative diseases such as Alzheimer's disease."], ["INTRODUCTION: Parkinson's disease is a chronic neurodegenerative multisystemic disorder that affects approximately 2% of the population over 65 years old."], ['With an aging U.S. population, advancements in the treatment of Alzheimer disease (AD) and other neurodegenerative diseases are key to the maximization of health span.', 'In this review, we examine the paradigm of neurotheranostics and how PET biomarkers of amyloid, tau, inflammation, and neurodegeneration could characterize the pathologic stage of AD and therefore allow for personalized therapy.'], ['Conserved induction of MHC-I, Lilrs, and Pilrs with aging and AD opens the possibility of cell-autonomous MHC-I signaling to regulate microglial reactivation with aging and neurodegeneration.'], ['High-resolution omics, particularly single-cell and spatial transcriptomic profiling, are rapidly enhancing our comprehension of the normal molecular diversity of gliovascular cells, as well as their age-related changes that contribute to neurodegeneration.', 'In this review, we present an overview of the molecular features of neurovascular and glial cells that have been recently discovered through omic profiling, with a focus on those that have potentially significant functional implications and/or show cross-species differences between human and mouse, and that are linked to vascular deficits and inflammatory pathways in ageing and neurodegenerative disorders.'], ['METHODS: Prospective cohort study participants were community-dwelling adults without dementia and other degenerative disorders and baseline and follow-up, including N=1054 participants aged >=55 free of cognitive frailty at baseline, with complete baseline (March 6, 2009, to June 11, 2013) and follow-up data at 3-5 years later (January 16, 2013 to August 24, 2018).'], ['We demonstrate SIT on two tasks: predicting longitudinal brain MRIs in patients with various stages of neurodegeneration, and visualizing changes with age and stroke severity in clinical brain scans of stroke patients.'], ["Parkinson's disease (PD) is a relentlessly progressive neurodegenerative disorder with typical motor symptoms that include rigidity, tremor, and akinesia/bradykinesia, in addition to a host of non-motor symptoms."], ['BACKGROUND: High gait variability is associated with neurodegeneration and cognitive impairments and is predictive of cognitive impairment and dementia.'], ["The most common neurodegenerative diseases (NDDs), such as Alzheimer's disease (AD) and Parkinson's disease (PD), are the seventh leading cause of mortality and morbidity in developed countries."], ['Osteoarthritis (OA) is a degenerative joint disease commonly found in middle-aged and older people.'], ['Vestibular agnosia is found in ageing, neurodegeneration and traumatic brain injury, and results in dramatically increased missed BPPV diagnoses.'], ['The significant increase in the elderly population and the high incidence of chronic and degenerative diseases are a matter of concern with regard to issues inherent to promotion of autonomy and preservation of human rights and quality of life in this population group.'], ["Alzheimer's Disease (AD) is a multifactorial, progressive, and chronic neurodegenerative disorder associated with the aging process.", 'Therefore, the microbiota-gut-brain axis has a significant impact on neurodegenerative disorders.', 'Conversely, low levels of omega-3 polyunsaturated fatty acids may be linked to neurodegenerative diseases.'], ['Astrocytic dysfunction is central to age-related neurodegenerative diseases.'], ['There is increasing interest in life space as a holistic measure of function in older adults, but the association between change in life space and incident neurodegenerative disease is unknown.', 'Objective: To evaluate the association between change in life space and cognitive decline or incident neurodegenerative disease over 7 years among community-dwelling older men.', 'Conclusions and Relevance: In this study of 1684 men followed up over 7 years, change in life space was associated with faster cognitive decline and increased likelihood of neurodegenerative illness.', 'Future studies should examine the role of clinician assessments or wearable electronics in tracking life space in older adults at risk of cognitive decline and neurodegenerative illness.'], ["Alzheimer's, Parkinson's, and Huntington's are the most common neurodegenerative diseases that are incurable and affect the elderly population.", 'With the possibility of using insect models to investigate neurodegenerative diseases.'], ['It has been proven that a Klotho deficit may contribute to the development of various nervous system pathologies, such as behavioral disorders or neurodegeneration.'], ["Parkinson's disease (PD) is the second most common neurodegenerative disorder after Alzheimer's disease."], ["It's uncertain whether Abeta is intrinsically toxic or activates downstream neurodegeneration pathways."], ["Neurological diseases, including neurodegenerative and neurodevelopmental disorders, affect nearly one in six of the world's population."], ["There are numerous studies and developed drugs for cognitive dysfunction in neurodegenerative diseases, such as Alzheimer's disease (AD); however, their clinical effectiveness remains equivocal.", 'This review investigated and summarized the regulation of neutrophil function during cognitive impairment caused by various degenerative diseases.'], ["BACKGROUND: Low-grade, chronic inflammation in the central nervous system characterized by glial reactivity is one of the major hallmarks for aging-related neurodegenerative diseases like Alzheimer's disease (AD).", 'The basal forebrain cholinergic neurons (BFCN) provide the primary source of cholinergic innervation of the human cerebral cortex and may be differentially vulnerable in various neurodegenerative diseases.'], ["The impairment of hippocampal neurogenesis in adults may lead to neurodegenerative disease, such as Alzheimer's disease.", 'Miquelianin (quercetin-3-O-beta-d-glucuronide, Q3GA) is a constituent of the nuciferine leaf polyphenol extract (NLPE), and it has protective effects against neurodegeneration.', 'Taken together, the NLPE containing Q3GA to promote neurogenesis involving the upregulation of TrkR and the PI3K/Akt signaling pathway might be potentiated as an alternative strategy for the treatment of neurodegeneration.'], ['Importantly, AAV9 delivery of hPS1 ameliorates neurodegeneration in the cerebral cortex of aged Psen mutant mice, as shown by the reversal of age-dependent loss of cortical neurons and elevated microgliosis and astrogliosis.', 'These results together show that moderate hPS1 expression by AAV9 is sufficient to rescue impaired gamma-secretase activity, synaptic and memory deficits, and neurodegeneration caused by Psen mutations in mouse models.'], ['While brain atrophy and cognitive decline are well-established in the advanced stages of tauopathy, it is unclear how the early pathological processes manifest prior to extensive neurodegeneration.'], ['The imbalance of homeostatic functions that support the exchange of fluids and solutes in the brain tissue is observed both in physiological aging and in the development of pathology of the nervous system with long-term consequences - from impaired synaptic signaling to the development of neurodegenerative diseases.', 'At the same time, the discovery of aquaporin-dependent clearance pathways in the brain made it possible to identify new mechanisms underlying the etiology and progression of neurodegeneration and neuroinflammation.'], ["Alzheimer's disease(AD) is a neurodegenerative disease that occurs mostly in the elderly and is characterized by chronic progressive cognitive dysfunction, which seriously threatens the health and life-quality of patients."], ['Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by progressive loss of motor neurons in the spinal cord.'], ['Successful correlations would provide reference values for the early identification of neurodegeneration in canine patients.', 'Research efforts should work to deliver information using blood biomarkers, comorbidities, and wearable technologies to track and evaluate biometric data associated with neurodegeneration and cognitive decline that can be used by both human and companion animal researchers.'], ['Neurodegenerative diseases (NDs) are a heterogeneous group of aging-associated ailments characterized by interrupting cellular proteostasic machinery and the misfolding of distinct proteins to form toxic aggregates in neurons.', "Neurodegenerative diseases, which include Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS), Huntington's disease (HD), and others, are becoming an increasing threat to human health worldwide.", 'In this review, we elucidate the potential of C. elegans as a versatile platform for systematic dissection of the molecular basis of human disease, focusing on neurodegenerative disorders, and may help better our understanding of the disease mechanisms and search for new therapeutics for these devastating diseases.'], ['Understanding the mechanisms by which exercise affects the brain is essential to understand the brain plasticity following exercise, guiding therapeutic approaches to improve the quality of life, especially in obesity, ageing, neurodegenerative disorders, and following traumatic brain injury.'], ["Human studies consistently identify bioenergetic maladaptations in brains upon aging and neurodegenerative disorders of aging (NDAs), such as Alzheimer's disease, Parkinson's disease, Huntington's disease, and Amyotrophic lateral sclerosis.", 'Axonopathy is often an early sign of neurodegeneration.'], ['BACKGROUND: Patients with dementia with Lewy bodies (DLB) have a higher probability of seizures than in normal aging and in other types of neurodegenerative disorders.', 'This study extends the spectrum of neurodegenerative disorders in which epileptiform discharges occurs at an elevated frequency.', 'It is possible that epileptiform discharges are, therefore, a consequence of neurodegeneration.'], ['Thus, sHLA class I could be considered a biomarker of neurodegeneration in certain HLA class I carriers.'], ['Pig is a good model for human neurodegenerative disease, but our understanding of the regulatory program of the pig hippocampus and its cross-species conservation in humans remains limited.', 'The present study provides a single nucleus-accessible chromatin landscape of the pig hippocampus at different developmental stages and is helpful for the exploration of pigs as a biomedical model in human neurodegenerative diseases.'], ['DISCUSSION: The canonical changes to episodic memory observed in aging and neurodegenerative disease are mirrored in the free recall of real-life events.'], ['Changes in physiological protein structure can lead to protein conformational disorders including neurodegeneration.', 'Therefore, this study signifies the potential of bioflavonoids for future treatment of many proteopathies including neurodegeneration.Communicated by Ramaswamy H. Sarma.'], ["Neurodegenerative diseases remain the most prevalent and unsolved health problems in human society, especially Alzheimer's disease (AD) and Parkinson's disease (PD).", 'The pathogenesis, pathology, and potential clinical treatments of neurodegenerative diseases still require in-depth research.', 'In the wake of the association between pandemics and a growing number of neurodegeneration patients, there has been growing speculation that infections are linked to AD and PD.', 'But how neurodegeneration is related to bacterial chronic infection has not been thoroughly investigated.', 'We observed clustering of the differentially expressed genes (DEGs) in the upstream and downstream of AD and PD-related KEGG pathways, hence confirming their causal association with AD and PD and providing new perspectives on the true cause of neurodegeneration.'], ['Osteoarthritis (OA) is a degenerative disease that leads to joint pain and stiffness and is one of the leading causes of disability and pain worldwide.'], ['On the other hand, longevity has contributed to increased prevalence of age-related diseases, including neurodegenerative disorders, which complicate clinical management, increasing healthcare expenditures.', 'Should neurocognitive disorders in the elderly with lifelong schizophrenia be treated differently than age-related neurodegeneration?'], ["BACKGROUND: Alzheimer's disease (AD) is the most common neurodegenerative disorder in the elderly, resulting in gradual destruction of cognitive abilities."], ['Here we describe an integrated neurodegeneration checkpoint response to early pathological changes that restricts further disease progression and preserves cognitive function.', 'Deletion of REST in the 3xTg and J20 AD mouse models accelerates Abeta deposition and the accumulation of misfolded and phosphorylated tau, leading to neurodegeneration and cognitive decline.', 'Thus, REST mediates a neurodegeneration checkpoint response with multiple molecular targets that may protect against the onset of AD.'], ["Neurodegenerative disorders such as Alzheimer's disease (AD) develop over a preclinical period of many years beginning in midlife."], ['Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) comprise a spectrum of neurodegenerative diseases linked to TDP-43 proteinopathy, which at the cellular level, is characterized by loss of nuclear TDP-43 and accumulation of cytoplasmic TDP-43 inclusions that ultimately cause RNA processing defects including dysregulation of splicing, mRNA transport and translation.'], ['Age-related disorders include neurodegenerative diseases, hypertension, cardiovascular disease, and type 2 diabetes.'], ['Lipid metabolism was reported to be involved in many degenerative diseases.'], ['Pathological aging of the nervous system results in a series of neurodegenerative diseases and can cause disability and death in the elderly.', 'Then by comparing their popularity of use as well as active components based on the research articles, five common Chinese herbal medicines namely Ginseng Radix, Lycii Fructus, Astragali Radix, Coptidis Rhizoma and Ginkgo Folium, were confirmed to be the most related to anti-nervous system aging and neural degenerative diseases.'], ["Alzheimer's disease (AD) is a neurodegenerative disease that occurs especially in advanced ages."], ['Mitochondrial function declines with age, and many pathological processes in neurodegenerative diseases stem from this dysfunction when mitochondria fail to produce the necessary energy required.'], ['Although the sense of smell decreases with disease and aging, olfactory impairment may be correlated with frailty as a symptom of neurodegenerative diseases.'], ["BACKGROUND: Parkinson's disease (PD) is a common neurodegenerative disease in the elderly."], ['In this hypothesis article, we discuss how such current outdated nosology of dementia is a key roadblock to precision medicine and articulate how Network Medicine enables the substitution of clinicopathologic phenotypes with molecular endotypes and propose a new framework to achieve precision and curative medicine for patients with neurodegenerative disorders.'], ["Alzheimer's disease (AD) is a progressive, age-related neurodegenerative disorder that affects a large proportion of the elderly population."], ["METHODS: We measured MGDGs by ultrahigh performance liquid chromatography tandem mass spectrometry in postmortem dorsolateral prefrontal cortex gray matter and subcortical corona radiata white matter samples derived from three cohorts of participants: the Framingham Heart Study, the Boston University Alzheimer's Disease Research Center, and the Arizona Study of Aging and Neurodegenerative Disorders/Brain and Body Donation Program (total n = 288)."], ['Recent epigenetic and transcriptomic characterizations of the nervous system have revealed intricate molecular details about the aging brain and the pathogenesis of neurodegenerative diseases.'], ['Mini-Mental State Examination score <25, brain trauma, neurological disease, neurodegenerative disorders, depression or poor Swedish language skills were criteria for exclusion.'], ['Cockayne syndrome (CS) and UV-sensitive syndrome (UVSS) are rare genetic disorders caused by mutation of the DNA repair and multifunctional CSA or CSB protein, but only CS patients display a progeroid and neurodegenerative phenotype, providing a unique conceptual and experimental paradigm.'], ['These people will be in fact at higher (or lower) risk for many different age-associated diseases, including cardiovascular diseases, neurodegeneration, cancer, etc.', 'An overview of selected biomarkers will be discussed in this regard, in particular we will focus on biomarkers related to metabolic stress response, inflammation, and cell death (in particular in neurodegeneration), all phenomena connected to inflammaging (chronic, low-grade, age-associated inflammation).'], ['Nicotinamide mononucleotide (NMN) is a precursor for NAD+ biosynthesis, and in vitro/in vivo studies have demonstrated that NMN supplementation increases NAD+ concentration and could mitigate ageing-related disorders such as oxidative stress, DNA damage, neurodegeneration and inflammatory responses.'], ['BACKGROUND: Accumulation of deoxyribonucleic acid (DNA) damage diminishes cellular health, increases the risk of developmental and degenerative diseases and accelerates aging.', 'DESIGN: We conducted systematic literature searches of the PubMed database to identify interventional, prospective, cross-sectional, or in vitro studies that explored the association between nutrients and established biomarkers of DNA damage associated with developmental and degenerative disease risk.'], ['Due to their essential functions, dysregulation of nuclear pore complexes (NPCs) is strongly associated with numerous human diseases, including neurodegeneration and cancer[1].'], ["Parkinson's disease (PD) is a common, progressive neurodegenerative disorder characterized by substantia nigra dopamine cell death and a varied clinical picture that affects older people.", 'Recently disease-modifying strategies like cell replacement therapies combined with other therapeutic approaches, such as utilizing natural compounds or biomaterials, are proposed to modify the underlying neurodegeneration.'], ['Aging is an inevitable risk factor for many diseases including cardiovascular diseases, neurodegenerative diseases, cancer, and diabetes.'], ['Life expectancy is increasing throughout the world and coincides with a rise in non-communicable diseases (NCDs), especially for metabolic disease that includes diabetes mellitus (DM) and neurodegenerative disorders.', 'These clinical challenges to address the interplay between metabolic and neurodegenerative disorders warrant innovative strategies that can focus upon the underlying mechanisms of aging-related disorders, oxidative stress, cell senescence, and cell death.', 'Programmed cell death pathways that involve autophagy, apoptosis, ferroptosis, and pyroptosis can play a critical role in metabolic and neurodegenerative disorders and oversee processes that include insulin resistance, beta-cell function, mitochondrial integrity, reactive oxygen species release, and inflammatory cell activation.'], ['It is a severe neurodegenerative disease that primarily affects the elderly and causes significant brain cell death.'], ['The potential of combining SCC with genetic information and blood biomarkers of neurodegenerative diseases for risk assessment of dementia and depression in the absence of dementia among community-dwelling older adults has so far not been explored.', 'Genetic information (APOE epsilon4 genotype) and blood-based biomarkers of neurodegenerative diseases (glial fibrillary acidic protein; GFAP, neurofilament light chain; NfL, phosphorylated tau181; p-tau181) were available in the ESTHER study and were determined with Simoa Technology in a nested case-control design.'], ['Emerging evidence shows that the meninges conduct essential immune surveillance and immune defense at the brain border, and the dysfunction of meningeal immunity contributes to aging and neurodegeneration.'], ['However, the normal function of APP and the importance of that role in neurodegenerative disease is less clear.', 'We recover the Drosophila ortholog of APP, Appl, in an unbiased forward genetic screen for neurodegeneration mutants.'], ['OBJECTIVE: The study explored the change in handwritten signature in neurodegenerative diseases by using of a rater-based approach.', 'CONCLUSION: The findings suggest a resistance of handwritten signature in neurodegenerative diseases and in physiological aging, also suggesting that the signature may be an unreliable indicator of the cognitive status in AD and FTD, at least if subjectively evaluated.'], ['When making a comparison of ACP between HD patients and patients with other neurodegenerative disorders in nursing homes, the ECPs emphasized the similarities.'], ['Understanding the potential relationship between brainstem demyelination and motor function may be useful for the early diagnosis of neurodegenerative diseases and to understand age-related gait impairments that have no apparent cause.', 'free of neurodegenerative diseases or cognitive impairment, myelin content was assessed as the myelin water fraction (MWF), a direct MRI measure of myelin content, and longitudinal and transverse relaxation rates (R1 and R2), which are sensitive MRI measures of myelin content.', 'These original findings provide evidence that the level of brainstem myelination may affect gait performance among cognitively unimpaired adults who are free from any clinically detectable neurodegenerative diseases.', "Further studies are needed to understand the longitudinal changes in brainstem myelination with aging and neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease."], ["Alzheimer's disease (AD) is a severe neurodegenerative disease in older people."], ['The senescence-accelerated prone-8 (SAMP8) mouse strain exhibits early cognitive loss that mimics the deterioration of learning and memory in the elderly and is widely used as a model of aging and neurodegenerative diseases.'], ['Small molecules mimicking calorie restriction to stimulate sirtuin activity are attractive therapeutics against age-related disorders such as cardiovascular diseases, diabetes and neurodegeneration.'], ["Aging is the main risk factor for the appearance of age-related neurodegenerative diseases, including Alzheimer's disease (AD)."], ['Low-dose radiotherapy (LDRT) has been used for decades in the treatment of patients with inflammatory and/or degenerative diseases and has proven a viable option even in cohorts of patients with a rather poor prognosis.'], ['Disruptions in circadian rhythms can occur in healthy aging; however, these changes are more severe and pervasive in individuals with age-related and neurodegenerative diseases, such as dementia.', 'Circadian rhythm alterations are also present in preclinical stages of dementia, for example, in patients with mild cognitive impairments (MCI); thus, providing a unique window of opportunity for early intervention in neurodegenerative disorders.', 'In addition, preliminary evidence indicates that interventions aimed at restoring regular circadian rhythms may prevent or halt the progress of neurodegenerative diseases and mitigate their related cognitive impairments.']]
numbers of articles: 6365
JT: ['Journal of ovarian research', 'European review for medical and pharmacological sciences', 'Omics : a journal of integrative biology', 'The journal of physical chemistry. B', 'Frontiers in immunology', 'Nutrients', 'Medicina (Kaunas, Lithuania)', 'Cells', 'Neurologia i neurochirurgia polska', 'Acta neuropathologica communications', 'International immunopharmacology', 'Scientific reports', 'Molecular cell', 'Acta biochimica Polonica', 'Molecules (Basel, Switzerland)', 'Nutrients', 'International journal of molecular sciences', 'International journal of molecular sciences', 'International journal of molecular sciences', 'Continuum (Minneapolis, Minn.)', 'IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society', 'Journal of materials chemistry. B', 'Advances in clinical chemistry', 'Journal of nuclear medicine : official publication, Society of Nuclear Medicine', 'Journal of nuclear medicine : official publication, Society of Nuclear Medicine', 'Metabolism: clinical and experimental', 'Cells', 'Scientific data', 'Experimental eye research', 'PloS one', 'Bioengineered', 'eLife', 'Cellular immunology', 'Open veterinary journal', 'Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie', 'JAMA psychiatry', 'BMC psychiatry', 'Neuroscience research', 'Neurobiology of disease', 'Nutrients', 'International journal of molecular sciences', 'Fluids and barriers of the CNS', 'International journal of biological macromolecules', "Journal of Alzheimer's disease : JAD", 'Revue neurologique', 'Ageing research reviews', 'Journal of molecular neuroscience : MN', 'JAMA network open', 'Advances in mind-body medicine', 'GeroScience', 'Molecules (Basel, Switzerland)', 'Nutrients', 'International journal of molecular sciences', 'International journal of molecular sciences', "Alzheimer's research & therapy", 'Gene', 'Omics : a journal of integrative biology', 'GeroScience', 'Scientific reports', 'JAMA neurology', 'Science advances', 'Chemical biology & drug design', 'Journal of applied physiology (Bethesda, Md. : 1985)', 'Nucleic acids research', 'Oxidative medicine and cellular longevity', 'BMJ (Clinical research ed.)', 'Neurology', 'Journal of neuroinflammation', 'Human brain mapping', 'Acta neuropathologica communications', 'Stem cell research & therapy', 'International journal of environmental research and public health', 'International journal of molecular sciences', 'Molecules (Basel, Switzerland)', 'Neurobiology of disease', 'Neurobiology of disease', 'NeuroImage. Clinical', 'Translational neurodegeneration', 'NeuroImage', 'Redox biology', 'Nature neuroscience', 'Brain : a journal of neurology', 'JAMA neurology', 'Bioorganic chemistry', 'Metabolic brain disease', 'Aging cell', 'Physiological reviews', 'The Lancet. Digital health', 'Mitochondrion', 'Nutrients', 'International journal of environmental research and public health', 'International journal of molecular sciences', 'Genes', 'Cells', 'Neurobiology of aging', 'Expert review of neurotherapeutics', 'Fluids and barriers of the CNS', "Journal of Alzheimer's disease : JAD", 'Yi chuan = Hereditas', 'Journal of neural transmission (Vienna, Austria : 1996)', 'European journal of pharmacology', 'Neurotoxicity research', 'Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics', 'Annals of neurology', 'Free radical biology & medicine', 'Neurobiology of aging', 'Experimental gerontology', 'Nutrients', 'Parkinsonism & related disorders', 'Sensors (Basel, Switzerland)', 'International journal of molecular sciences', 'International journal of molecular sciences', 'Cells', 'JAMA psychiatry', 'Pharmacological research', 'Molecular neurodegeneration', 'Neurobiology of aging', 'Geriatrics & gerontology international', 'BioFactors (Oxford, England)', 'Experimental gerontology', 'International journal of molecular sciences', 'Nutrients', 'Nutrients', 'Sensors (Basel, Switzerland)', "Journal of Alzheimer's disease : JAD", 'Cells', 'Frontiers in cellular and infection microbiology', 'Theranostics', 'American journal of physiology. Cell physiology', 'Acta neuropathologica', "Alzheimer's research & therapy", 'Topics in antiviral medicine', 'Journal of biomedical science', 'NeuroImage. Clinical', 'The journal of nutrition, health & aging', 'Nature reviews. Rheumatology', 'Molecules (Basel, Switzerland)', 'International journal of molecular sciences', 'International journal of molecular sciences', 'Cells', 'EBioMedicine', 'Journal of neurovirology', 'Clinics (Sao Paulo, Brazil)', 'Environmental research', 'Experimental gerontology', 'Journal of clinical and experimental neuropsychology', 'Bone', 'The British journal of radiology', 'Journal of neuroinflammation', 'Colloids and surfaces. B, Biointerfaces', 'The Journal of neuroscience : the official journal of the Society for Neuroscience', 'Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics', 'Neuropharmacology', 'Neural plasticity', 'Oxidative medicine and cellular longevity', 'FEBS open bio', 'NeuroImage', 'The Lancet. Neurology', 'Scientific data', 'Nutrients', 'Cells', 'Genes', 'Current Alzheimer research', 'Cellular and molecular life sciences : CMLS', 'Proceedings of the National Academy of Sciences of the United States of America', 'Cellular and molecular life sciences : CMLS', 'Mechanisms of ageing and development', 'Experimental gerontology', 'Neurosurgery', 'Advances in experimental medicine and biology', 'BMC geriatrics', 'The American journal of clinical nutrition', 'Transplant immunology', 'Molecules (Basel, Switzerland)', 'Nutrients', 'Molecular neurobiology', 'Biological psychiatry', 'NeuroImage', 'Journal of integrative neuroscience', "Alzheimer's research & therapy", 'NeuroImage', "Naunyn-Schmiedeberg's archives of pharmacology", 'Journal of affective disorders', 'Neurobiology of disease', 'Life sciences', 'Current neuropharmacology', 'Biosensors & bioelectronics', 'Nutrients', 'European journal of medicinal chemistry', 'Progress in neurobiology', 'Oxidative medicine and cellular longevity', 'Biomolecules', 'Cells', 'Cells', 'Cells', 'Environmental health perspectives', 'Food & function', 'Journal of food biochemistry', "Journal of Huntington's disease", 'Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine', 'Ageing research reviews', 'GeroScience', 'Journal of pharmaceutical and biomedical analysis', 'Experimental gerontology', "Alzheimer's research & therapy", 'Current Alzheimer research', "Alzheimer's research & therapy", 'Frontiers in public health', "Journal of Alzheimer's disease : JAD", 'Aging cell', 'Mutation research. Reviews in mutation research', 'Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference', 'Biochimie', 'Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing', 'Current opinion in lipidology', 'TheScientificWorldJournal', 'International journal of molecular sciences', 'Journal of neuroscience research', 'Current Alzheimer research', 'Molecular neurodegeneration', 'European neurology', 'Free radical biology & medicine', 'Journal of pharmaceutical and biomedical analysis', 'Human brain mapping', 'Cell death and differentiation', 'Current molecular pharmacology', 'Current medicinal chemistry', 'Journal of biochemical and molecular toxicology', 'Nutrients', 'International journal of molecular sciences', 'International journal of molecular sciences', 'Biomolecules', 'Molecular biology reports', 'Current opinion in neurobiology', 'The Journal of clinical investigation', 'Microvascular research', 'The Journal of neuroscience : the official journal of the Society for Neuroscience', 'Vascular health and risk management', 'Neuroscience and biobehavioral reviews', 'Biochemical Society transactions', 'PLoS genetics', 'Current drug delivery', "Journal of Alzheimer's disease : JAD", 'Cortex; a journal devoted to the study of the nervous system and behavior', 'Molecular and cellular neurosciences', 'Advances in experimental medicine and biology', 'Sensors (Basel, Switzerland)', 'Glycoconjugate journal', 'Signal transduction and targeted therapy', 'Neurology India', 'Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society', 'Molecular neurodegeneration', 'Brain imaging and behavior', 'Ageing research reviews', 'Journal of neurovirology', 'Best practice & research. Clinical rheumatology', 'Medical image analysis', 'Molecular biology reports', 'Science translational medicine', 'Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics', 'JAMA neurology', 'The Journal of nutrition', 'Current opinion in endocrinology, diabetes, and obesity', 'Cellular and molecular life sciences : CMLS', 'Aging', 'Stroke', 'Annual review of pathology', 'Journal of molecular medicine (Berlin, Germany)', 'Rejuvenation research', 'Cortex; a journal devoted to the study of the nervous system and behavior', 'Ageing research reviews', 'Kidney international', 'Cells', 'Cells', 'Cells', 'Cells', 'International journal of molecular sciences', 'Biomolecules', 'Computers in biology and medicine', 'Cellular and molecular life sciences : CMLS', 'Ageing research reviews', 'Progress in neurobiology', 'Journal of molecular neuroscience : MN', 'Missouri medicine', 'Neuroscience letters', 'European archives of psychiatry and clinical neuroscience', 'Journal of the Association for Research in Otolaryngology : JARO', 'The American journal of clinical nutrition', 'Experimental gerontology', 'Essays in biochemistry', 'Neurobiology of aging', 'Cell death and differentiation', 'JAMA network open', 'Current opinion in pharmacology', 'Frontiers in immunology', 'Frontiers in immunology', "Journal of Parkinson's disease", "Journal of Parkinson's disease", 'Clinics in geriatric medicine', 'Aging cell', 'Medicine', 'World journal of gastroenterology', 'Molecular psychiatry', 'CNS & neurological disorders drug targets', 'International journal of molecular sciences', 'Cells', 'Cells', "Alzheimer's & dementia : the journal of the Alzheimer's Association", "Journal of Alzheimer's disease : JAD", 'Marine drugs', 'Journal of electromyography and kinesiology : official journal of the International Society of Electrophysiological Kinesiology', 'Ageing research reviews', 'Experimental & molecular medicine', 'Free radical biology & medicine', 'Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie', 'Brain research bulletin', 'Free radical biology & medicine', 'Aging clinical and experimental research', 'Aging cell', 'Mechanisms of ageing and development', 'Mechanisms of ageing and development', "Journal of Alzheimer's disease : JAD", 'CNS neuroscience & therapeutics', 'International journal of molecular sciences', 'International journal of molecular sciences', 'International journal of molecular sciences', 'Mitochondrion', 'Neurosurgery', 'Scientific reports', 'Journal of ethnopharmacology', 'BMJ open', 'Journal of neurochemistry', 'European journal of histochemistry : EJH', 'Endocrinology', 'Neurobiology of disease', 'Journal of visualized experiments : JoVE', 'Aging cell', 'Life sciences', 'International journal of molecular sciences', 'International journal of molecular sciences', 'International journal of molecular sciences', 'Metabolic brain disease', 'BMC neurology', 'Journal of internal medicine', 'Current Alzheimer research', 'Translational psychiatry', 'The Lancet. Neurology', 'Molecular brain', 'Journal of molecular neuroscience : MN', 'Scientific reports', 'Glia', 'Ageing research reviews', 'Acta neuropathologica communications', 'Phytomedicine : international journal of phytotherapy and phytopharmacology', 'Neurobiology of disease', 'PloS one', 'Journal of neuropathology and experimental neurology', 'Missouri medicine', 'Oxidative medicine and cellular longevity', 'Nutrients', "Journal of Alzheimer's disease : JAD", 'International journal of molecular sciences', 'International journal of molecular sciences', 'International journal of molecular sciences', 'Cells', 'Biomolecules', 'Mechanisms of ageing and development', 'Current eye research', 'Disease models & mechanisms', 'Chaos (Woodbury, N.Y.)', 'Journal of healthcare engineering', 'Neuroreport', 'Journal of cellular and molecular medicine', 'Ageing research reviews', 'Methods in molecular biology (Clifton, N.J.)', 'Neuropathology and applied neurobiology', 'BMC musculoskeletal disorders', 'Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine', 'European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery', 'Cerebral cortex (New York, N.Y. : 1991)', 'Autophagy', 'Neuropathology and applied neurobiology', 'Medical image analysis', 'Journal of the neurological sciences', 'Aging', 'European journal of neurology', 'JAMA neurology', "Alzheimer's & dementia : the journal of the Alzheimer's Association", 'Trends in neurosciences', 'The Lancet. Neurology', 'Proceedings of the National Academy of Sciences of the United States of America', 'The Lancet. Neurology', 'International journal of molecular sciences', 'International journal of molecular sciences', 'Brain and behavior', 'Neuropsychology', 'Aging', 'Trends in neurosciences', 'Neurobiology of aging', 'International journal of molecular sciences', 'Current Alzheimer research', 'Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia', 'Scientific reports', 'The Journal of physiology', 'The journals of gerontology. Series A, Biological sciences and medical sciences', 'Advances in experimental medicine and biology', 'Advances in experimental medicine and biology', 'BMC cardiovascular disorders', 'NeuroImage. Clinical', 'Hereditas', 'Journal of immunology research', 'Scientific reports', 'Communications biology', 'PloS one', 'Journal of neuroscience research', 'Handbook of clinical neurology', 'Prion', 'Journal of neural transmission (Vienna, Austria : 1996)', "Journal of Alzheimer's disease : JAD", "Journal of Alzheimer's disease : JAD", "Journal of Alzheimer's disease : JAD", "Journal of Alzheimer's disease : JAD", 'Neuroscience bulletin', 'BMC neurology', 'Neurology', 'Brain connectivity', 'International journal of environmental research and public health', 'Molecules (Basel, Switzerland)', 'Nutrients', 'Nutrients', 'Biomolecules', 'International journal of molecular sciences', 'International journal of molecular sciences', 'Journal of the history of the neurosciences', 'Disease models & mechanisms', 'Journal of neurology, neurosurgery, and psychiatry', 'Biology open', 'Frontiers in immunology', 'Nature reviews. Cardiology', 'Archives of gerontology and geriatrics', 'Neurobiology of disease', "Alzheimer's & dementia : the journal of the Alzheimer's Association", 'Brain pathology (Zurich, Switzerland)', 'Frontiers in immunology', 'NeuroImage', 'Journal of Ayub Medical College, Abbottabad : JAMC', 'Mechanisms of ageing and development', 'NeuroImage. Clinical', 'DNA repair', 'NeuroImage', 'Shock (Augusta, Ga.)', 'Disease models & mechanisms', 'Journal of geriatric psychiatry and neurology', 'Scientific reports', 'Current pharmaceutical design', "The journal of prevention of Alzheimer's disease", "The journal of prevention of Alzheimer's disease", 'Journal of neurovirology', 'Mechanisms of ageing and development', 'Preventive medicine', 'Aging cell', 'Communications biology', 'International journal of environmental research and public health', 'Cells', 'Cells', 'International journal of molecular sciences', 'Neuroscience and biobehavioral reviews', 'Mechanisms of ageing and development', 'Nature neuroscience', 'Protein & cell', 'Progress in molecular and subcellular biology', 'Progress in molecular and subcellular biology', 'The European journal of neuroscience', 'Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie', 'Aging', 'GeroScience', 'Neurology', 'Nature neuroscience', 'NeuroImage', 'Methods in molecular biology (Clifton, N.J.)', "Journal of Alzheimer's disease : JAD", "Journal of Alzheimer's disease : JAD", "Journal of Alzheimer's disease : JAD", 'Mechanisms of ageing and development', 'Brain and language', 'Frontiers in cellular and infection microbiology', "Alzheimer's research & therapy", 'PloS one', 'Sleep', 'Mechanisms of ageing and development', 'Behavioural brain research', 'GeroScience', 'Metabolic brain disease', 'Annual review of genomics and human genetics', 'Molecular biology reports', "Journal of Alzheimer's disease : JAD", 'International journal of biological macromolecules', 'BMJ case reports', 'Alcohol (Fayetteville, N.Y.)', 'Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology', 'Human brain mapping', "Alzheimer's research & therapy", 'Acta neuropathologica', 'Current medicinal chemistry', "Alzheimer's research & therapy", 'Nutrients', 'Journal of cellular and molecular medicine', 'Developmental neurobiology', 'Frontiers in immunology', 'Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology', 'Neurochemical research', 'Stem cell research & therapy', 'International journal of molecular sciences', 'International journal of molecular sciences', 'International journal of molecular sciences', 'Cells', 'International journal of molecular sciences', 'International journal of molecular sciences', 'Journal of cell science', 'Aging cell', 'European journal of neurology', 'Theranostics', 'Experimental gerontology', 'Acta neurologica Belgica', 'Arquivos brasileiros de cardiologia', 'Accounts of chemical research', 'Current neuropharmacology', 'Journal of neurodevelopmental disorders', 'Archives of Iranian medicine', 'Neurochemistry international', 'Molecular psychiatry', 'The journals of gerontology. Series A, Biological sciences and medical sciences', 'Journal of neurotrauma', 'Ageing research reviews', 'Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics', 'Advances in cancer research', 'Brain connectivity', 'BMJ open', 'Cell', 'Acta neuropathologica communications', 'Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics', 'Current pharmaceutical biotechnology', 'Frontiers in neuroendocrinology', 'Cellular and molecular life sciences : CMLS', 'Expert opinion on therapeutic targets', 'Experimental gerontology', 'Current pharmaceutical biotechnology', 'Cell cycle (Georgetown, Tex.)', "Journal of Alzheimer's disease : JAD", 'Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS)', 'International journal of molecular sciences', 'Genes', 'International journal of molecular sciences', 'Nutrients', 'International journal of molecular sciences', 'International journal of molecular sciences', 'Journal of the American Medical Directors Association', 'PloS one', 'Current neuropharmacology', 'The FEBS journal', 'BMC neurology', 'Aging cell', 'Revista do Instituto de Medicina Tropical de Sao Paulo', 'Expert review of vaccines', 'Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics', 'Current topics in behavioral neurosciences', 'Free radical biology & medicine', "Alzheimer's research & therapy", 'Drug discovery today', 'Cell metabolism', 'BioFactors (Oxford, England)', 'Genome biology', 'Advances in clinical and experimental medicine : official organ Wroclaw Medical University', 'Mechanisms of ageing and development', 'Neurobiology of aging', 'Acta neuropathologica communications', 'BMC biology', 'Mathematical biosciences and engineering : MBE', 'Movement disorders : official journal of the Movement Disorder Society', 'Developmental biology', 'Clinica chimica acta; international journal of clinical chemistry', 'Ageing research reviews', 'Acta neuropathologica communications', 'eNeuro', 'Ageing research reviews', 'Aging cell', 'Aging clinical and experimental research', "Journal of Alzheimer's disease : JAD", 'The European journal of neuroscience', 'Neurobiology of disease', 'Vitamins and hormones', 'Annals of clinical and translational neurology', 'Acta neuropathologica', 'Aging', 'Journal of atherosclerosis and thrombosis', 'Neurochemical research', 'Medicina (Kaunas, Lithuania)', 'International journal of molecular sciences', 'Molecules (Basel, Switzerland)', 'BMJ open', 'BMJ case reports', 'Clinical interventions in aging', 'Stroke', 'Dementia and geriatric cognitive disorders', 'International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience', 'The Journal of neuroscience : the official journal of the Society for Neuroscience', "Journal of Alzheimer's disease : JAD", 'Amyotrophic lateral sclerosis & frontotemporal degeneration', 'Pharmacology research & perspectives', 'BMC public health', 'Mitochondrion', 'Stem cell reports', 'IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society', 'Journal of neuroscience research', 'Molecular medicine (Cambridge, Mass.)', 'Clinical neurology and neurosurgery', 'Journal of magnetic resonance imaging : JMRI', 'Radiology', 'Reviews in the neurosciences', 'NeuroImage', 'Journal of visualized experiments : JoVE', 'Ageing research reviews', 'Neuroscience letters', 'Molecular metabolism', 'Ageing research reviews', 'GeroScience', 'Pflugers Archiv : European journal of physiology', "Alzheimer's research & therapy", 'CNS & neurological disorders drug targets', 'The Journal of neuroscience : the official journal of the Society for Neuroscience', 'Human brain mapping', 'Current opinion in clinical nutrition and metabolic care', 'Amino acids', 'BMC medicine', 'European journal of medicinal chemistry', "Alzheimer's & dementia : the journal of the Alzheimer's Association", "Journal of Huntington's disease", 'Science advances', 'Nuclear medicine review. Central & Eastern Europe', 'BMJ open', 'Current pharmaceutical biotechnology', 'Cells', 'Analytical chemistry', "The journal of prevention of Alzheimer's disease", "The journal of prevention of Alzheimer's disease", 'Experimental gerontology', 'Clinical nutrition (Edinburgh, Scotland)', 'BMC musculoskeletal disorders', 'Cells', 'Environmental health perspectives', "Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde", 'Molecular genetics and metabolism', 'Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie', 'International journal of molecular sciences', 'Mechanisms of ageing and development', 'Current medicinal chemistry', 'Current aging science', 'Genes', 'Neuroinformatics', 'Molecular neurobiology', 'Nutrients', 'BioMed research international', 'Current aging science', 'Biogerontology', 'NeuroImage', 'Bioorganic & medicinal chemistry', 'Briefings in bioinformatics', 'PloS one', 'Applied microbiology and biotechnology', "Alzheimer's & dementia : the journal of the Alzheimer's Association", 'Clinical interventions in aging', 'Molecular neurobiology', 'International journal of obesity (2005)', 'Scientific reports', 'International journal of orthopaedic and trauma nursing', 'Cells', 'European neurology', 'Mitochondrion', 'Science translational medicine', 'International journal of environmental research and public health', 'The journal of physical chemistry. B', 'BMC medicine', 'Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism', 'Stress (Amsterdam, Netherlands)', 'NeuroImage', 'NeuroImage', 'International journal of molecular medicine', 'Scientific reports', 'The EMBO journal', 'Aging & mental health', 'Scientific reports', 'The Journal of investigative dermatology', 'Nutrients', 'Contemporary clinical trials', 'Movement disorders : official journal of the Movement Disorder Society', 'Proceedings of the National Academy of Sciences of the United States of America', 'Medicine', 'Gerontology', 'Neurobiology of aging', 'Life sciences', 'Advances in experimental medicine and biology', 'ACS chemical neuroscience', 'The Journal of experimental medicine', 'Molecular neurobiology', 'Cell death and differentiation', 'Molecular neurobiology', 'Metabolic brain disease', 'Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology', 'Acta neuropathologica communications', 'Antioxidants & redox signaling', 'Genome biology', 'International journal of molecular sciences', 'Acta neuropathologica communications', 'European journal of nutrition', 'Molecular and cellular biochemistry', 'Vision research', 'The Psychiatric quarterly', 'Acta neuropathologica', 'The bone & joint journal', 'International journal of molecular sciences', 'Mini reviews in medicinal chemistry', 'European journal of neurology', 'Human brain mapping', 'Frontiers in immunology', 'Brain connectivity', 'Journal of food biochemistry', 'Free radical biology & medicine', 'Journal of critical care', 'International journal of molecular sciences', 'Spine', "The journal of prevention of Alzheimer's disease", 'Nature', 'JAMA psychiatry', 'Medicinal research reviews', "Alzheimer's & dementia : the journal of the Alzheimer's Association", 'Cells', 'Pharmacology & therapeutics', 'JAMA neurology', 'FEBS letters', 'Current neurology and neuroscience reports', 'Human movement science', 'Scientific reports', 'Maturitas', 'BMC musculoskeletal disorders', 'Science advances', 'Brain : a journal of neurology', 'BMC musculoskeletal disorders', 'Scientific reports', 'Translational psychiatry', 'Bioorganic chemistry', 'Auris, nasus, larynx', 'Experimental neurology', 'Chemical Society reviews', 'Briefings in functional genomics', 'Neurobiology of aging', 'Einstein (Sao Paulo, Brazil)', 'Molecules (Basel, Switzerland)', 'Epilepsia', 'Molecular genetics and metabolism', 'Cerebral cortex (New York, N.Y. : 1991)', 'The Journal of nutrition', 'Experimental & molecular medicine', 'Frontiers in immunology', 'Physics in medicine and biology', 'BioEssays : news and reviews in molecular, cellular and developmental biology', 'Methods in molecular biology (Clifton, N.J.)', 'Translational psychiatry', 'Aging cell', 'Biomolecules', "Alzheimer's research & therapy", 'Brain research', 'Brain : a journal of neurology', 'Nutrients', 'Age and ageing', 'Aging', 'Aging', 'Frontiers in public health', 'Critical reviews in food science and nutrition', 'Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie', 'Neuro endocrinology letters', 'Reviews in the neurosciences', 'Neurobiology of disease', 'Gerodontology', 'Journal of materials chemistry. B', 'Neurodegenerative disease management', 'Molecules (Basel, Switzerland)', 'Pharmacological research', 'Journal of neuroscience research', 'Frontiers in immunology', 'Aging cell', 'Acta neuropathologica', 'Cells', 'Current pharmaceutical design', 'Frontiers in cellular and infection microbiology', 'Parkinsonism & related disorders', 'International journal of molecular sciences', 'Medicine', 'Oxidative medicine and cellular longevity', 'Scientific reports', 'Journal of applied physiology (Bethesda, Md. : 1985)', 'The Journal of clinical investigation', 'Disease models & mechanisms', 'Proceedings of the National Academy of Sciences of the United States of America', 'Advances in experimental medicine and biology', "Journal of Alzheimer's disease : JAD", "Journal of Parkinson's disease", "Journal of Alzheimer's disease : JAD", 'Bulletin of experimental biology and medicine', 'Journal of evidence-based integrative medicine', 'Aging', 'Molecules (Basel, Switzerland)', 'Anesthesia and analgesia', 'Journal of cellular and molecular medicine', "Journal of Alzheimer's disease : JAD", 'The EMBO journal', 'Neurobiology of disease', 'Annals of clinical and laboratory science', 'Biochimica et biophysica acta. Bioenergetics', 'Clinical interventions in aging', 'Neurological research', 'Biochemistry. Biokhimiia', 'Nutrients', 'International journal of molecular sciences', 'Brain stimulation', 'The Journal of cell biology', 'Physiological genomics', 'NeuroImage', 'PloS one', 'Italian journal of dermatology and venereology', 'International journal of molecular sciences', 'Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference', 'Sleep', 'Frontiers in public health', 'Computer methods and programs in biomedicine', 'International journal of medical informatics', 'Lung cancer (Amsterdam, Netherlands)', 'Pharmacological research', 'Experimental neurology', 'The Lancet. Public health', 'International journal of molecular sciences', 'Molecular and cellular biochemistry', 'Journal of neuropathology and experimental neurology', 'International journal of molecular sciences', 'Mechanisms of ageing and development', 'Trends in cell biology', 'Rejuvenation research', 'Neurochemistry international', 'Bio Systems', 'Journal of the American Geriatrics Society', 'Critical reviews in biochemistry and molecular biology', 'Ageing research reviews', 'Journal of applied physiology (Bethesda, Md. : 1985)', 'International journal of molecular sciences', 'Behavioural pharmacology', 'Philosophical transactions of the Royal Society of London. Series B, Biological sciences', 'Philosophical transactions of the Royal Society of London. Series B, Biological sciences', 'Current medicinal chemistry', 'NeuroImage. Clinical', 'Journal of the American Geriatrics Society', 'International journal of molecular sciences', 'International journal of molecular sciences', 'Molecular pharmaceutics', 'Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology', 'The International journal of neuroscience', 'Phytotherapy research : PTR', 'Oxidative medicine and cellular longevity', 'Multiple sclerosis and related disorders', 'Stem cell research', 'Disability and rehabilitation', 'Brain and behavior', 'Magnetic resonance in medicine', 'Food & function', 'Molecular neurodegeneration', 'International journal of molecular sciences', 'Amyotrophic lateral sclerosis & frontotemporal degeneration', 'Autonomic neuroscience : basic & clinical', 'Cell and tissue research', 'Neurologia (Barcelona, Spain)', 'Mechanisms of ageing and development', 'Nature communications', 'Neuropsychologia', 'International journal of molecular sciences', 'Neurosurgical focus', 'Nutrients', 'Molecular neurobiology', 'Journal of visualized experiments : JoVE', 'The European journal of neuroscience', 'Sleep medicine', 'Clinical neurology and neurosurgery', 'Journal of molecular medicine (Berlin, Germany)', 'Brain : a journal of neurology', 'Oxidative medicine and cellular longevity', 'Oxidative medicine and cellular longevity', 'International journal of molecular sciences', 'Neurology', 'Pharmacological research', 'Acta neuropathologica communications', 'Nature medicine', 'Methods in molecular biology (Clifton, N.J.)', "Journal of Alzheimer's disease : JAD", 'BMJ open', 'Progress in neurobiology', 'BMJ open', 'Cell host & microbe', 'International journal of environmental research and public health', 'International journal of environmental research and public health', 'Biomolecules', 'Frontiers in immunology', 'Journal of orthopaedic surgery and research', 'Cognitive science', 'Neurology', 'Neurochemistry international', 'Brain, behavior, and immunity', 'GeroScience', 'Chemical & pharmaceutical bulletin', 'Aging cell', 'International review of neurobiology', 'Scientific reports', 'Clinical infectious diseases : an official publication of the Infectious Diseases Society of America', 'Cell cycle (Georgetown, Tex.)', 'Mechanisms of ageing and development', 'BMJ open diabetes research & care', 'Rejuvenation research', 'The EMBO journal', 'Seminars in neurology', 'Reviews in the neurosciences', 'Clinical & experimental ophthalmology', 'NeuroImage. Clinical', 'Movement disorders : official journal of the Movement Disorder Society', 'Genes', 'Multiple sclerosis and related disorders', 'CNS & neurological disorders drug targets', 'NeuroImage', 'GeroScience', 'International journal of molecular sciences', 'Reviews in endocrine & metabolic disorders', 'Age and ageing', 'Neuroscience letters', 'Journal of neurochemistry', 'Reviews in the neurosciences', 'Age and ageing', 'Cell reports', 'International journal of molecular sciences', 'Social science & medicine (1982)', 'Journal of visualized experiments : JoVE', 'Brain pathology (Zurich, Switzerland)', 'Medicina (Kaunas, Lithuania)', 'Environmental science & technology', 'Canadian journal of physiology and pharmacology', 'Biomaterials science', 'Marine drugs', 'Neurobiology of aging', 'Mechanisms of ageing and development', 'Pflugers Archiv : European journal of physiology', 'Neurobiology of disease', 'Clinical neurology and neurosurgery', 'Mechanisms of ageing and development', 'Journal of magnetic resonance imaging : JMRI', 'Seminars in arthritis and rheumatism', 'Carcinogenesis', 'Neuroscience letters', 'Aging clinical and experimental research', 'Archives of toxicology', 'Advances in clinical and experimental medicine : official organ Wroclaw Medical University', 'Molecular psychiatry', 'Studies in health technology and informatics', 'Neuron', 'Aging', 'Nature reviews. Neuroscience', 'BMC biology', 'Neurobiology of disease', 'Cell biochemistry and biophysics', "Alzheimer's research & therapy", 'EBioMedicine', 'Acta neuropathologica communications', 'International journal of molecular sciences', 'Neurology', 'Scientific reports', 'Biochemical Society transactions', 'Neurotoxicity research', 'Translational research : the journal of laboratory and clinical medicine', 'Journal of visualized experiments : JoVE', "Journal of Alzheimer's disease : JAD", 'Aging cell', 'Current stem cell research & therapy', 'Experimental gerontology', 'Neuroscience letters', 'Neurology', 'JMIR mHealth and uHealth', 'Experimental gerontology', 'Neurodegenerative disease management', 'Theranostics', 'The European journal of neuroscience', "Alzheimer's & dementia : the journal of the Alzheimer's Association", 'Trends in biochemical sciences', 'Aging', 'Sensors (Basel, Switzerland)', 'Human brain mapping', 'Frontiers in neuroendocrinology', 'Aging', 'Ageing research reviews', 'Ageing research reviews', 'The journals of gerontology. Series A, Biological sciences and medical sciences', 'Omics : a journal of integrative biology', 'Current opinion in HIV and AIDS', 'Antioxidants & redox signaling', 'International journal of molecular sciences', 'Aging', 'Theranostics', 'Cells', 'Biotechnology letters', 'Neuroscience letters', 'The Lancet. Neurology', 'Advances in experimental medicine and biology', 'Ageing research reviews', 'Dysphagia', 'GeroScience', 'Pain research & management', 'GeroScience', 'Essays in biochemistry', 'Experimental gerontology', 'Pharmacological research', 'Neurobiology of aging', 'The journals of gerontology. Series A, Biological sciences and medical sciences', 'Neuropsychologia', 'The Journal of biological chemistry', 'International journal of molecular sciences', 'Journal of the American College of Cardiology', 'Cells', 'Cancer science', 'Journal of medical genetics', 'BMC medical genomics', 'PloS one', 'Open biology', 'Aging', 'Expert review of proteomics', 'Aging cell', 'Revue neurologique', 'Methods (San Diego, Calif.)', 'Current pharmaceutical design', 'International journal of molecular sciences', 'Methods in molecular biology (Clifton, N.J.)', 'Scientific reports', 'Disability and rehabilitation. Assistive technology', 'Neuroscience letters', 'BMC neurology', 'Dalton transactions (Cambridge, England : 2003)', 'Free radical biology & medicine', 'Cell metabolism', 'Advances in experimental medicine and biology', 'Prion', 'Chemico-biological interactions', 'Current neuropharmacology', 'Current neuropharmacology', 'FASEB journal : official publication of the Federation of American Societies for Experimental Biology', 'Molecules (Basel, Switzerland)', 'Journal of the International Neuropsychological Society : JINS', 'Combinatorial chemistry & high throughput screening', 'Advances in experimental medicine and biology', 'Progress in neurobiology', 'European review for medical and pharmacological sciences', 'Journal of anatomy', 'Annals of clinical and translational neurology', 'Cell transplantation', "Journal of Alzheimer's disease : JAD", 'Journal of neurochemistry', 'Advances in experimental medicine and biology', 'Advances in experimental medicine and biology', 'Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology', 'Molecular neurodegeneration', 'Antioxidants & redox signaling', "Alzheimer's research & therapy", 'International journal of molecular sciences', 'Dementia and geriatric cognitive disorders', 'Clinical chemistry and laboratory medicine', 'Annals of neurology', 'The Journal of neuropsychiatry and clinical neurosciences', 'Genes', "Journal of Alzheimer's disease : JAD", 'Advances in experimental medicine and biology', 'Neurology', 'Experimental & molecular medicine', 'Translational neurodegeneration', 'Neurobiology of disease', 'eLife', 'Rhinology', 'Endocrine, metabolic & immune disorders drug targets', 'The British journal of nutrition', 'The Journal of organic chemistry', 'Age and ageing', "Alzheimer's research & therapy", 'Developmental cell', 'Trends in cell biology', 'Journal of nuclear medicine : official publication, Society of Nuclear Medicine', 'Journal of molecular biology', 'Biogerontology', 'International journal of molecular sciences', 'NeuroImage', 'Ageing research reviews', 'Journal of neuroscience research', 'Journal of the science of food and agriculture', 'Human brain mapping', 'Behavioral neuroscience', 'Neuroscience and biobehavioral reviews', 'Autophagy', "Journal of Alzheimer's disease : JAD", "Journal of Alzheimer's disease : JAD", 'Annals of neurology', 'International journal of molecular sciences', 'mBio', 'Current Alzheimer research', 'BMC geriatrics', 'Cells', 'International journal of molecular sciences', 'Frontiers in immunology', 'Expert opinion on therapeutic targets', 'Current opinion in neurobiology', 'Biochimie', 'Ageing research reviews', 'Clinical interventions in aging', 'Journal of sleep research', 'Antioxidants & redox signaling', 'International journal of molecular sciences', 'NeuroImage. Clinical', 'PLoS medicine', 'Glia', 'Experimental neurology', 'Gerontology', 'Biochemistry. Biokhimiia', 'Bioanalysis', 'Computational and mathematical methods in medicine', 'Aging cell', 'The journals of gerontology. Series A, Biological sciences and medical sciences', 'Journal of food science', 'Scientific reports', 'Scientific reports', 'Current opinion in neurology', 'Learning & memory (Cold Spring Harbor, N.Y.)', 'International journal of molecular sciences', 'Experimental gerontology', 'BMC geriatrics', 'Biodemography and social biology', 'Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society', 'Clinical neurology and neurosurgery', 'Neurobiology of aging', 'Pharmacological reports : PR', 'F1000Research', 'Journal of translational medicine', 'International journal of molecular sciences', 'The Journal of biological chemistry', 'Medical hypotheses', 'BMJ open', 'Expert opinion on drug delivery', 'NeuroImage', 'Mechanisms of ageing and development', 'Journal of sleep research', 'Biochemical and biophysical research communications', 'World neurosurgery', 'The journal of nutrition, health & aging', 'Computers in biology and medicine', 'Current pharmaceutical biotechnology', 'Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society', 'Journal of the Royal Society, Interface', 'Rejuvenation research', 'Scientific reports', 'The Journal of neuroscience : the official journal of the Society for Neuroscience', 'Talanta', 'Experimental gerontology', 'International journal of molecular sciences', 'Mitochondrion', 'Nucleic acids research', 'International journal of environmental research and public health', 'Nature neuroscience', "Journal of Alzheimer's disease : JAD", 'Experimental gerontology', 'Medical hypotheses', 'Journal of biomolecular structure & dynamics', 'PLoS biology', 'The journals of gerontology. Series A, Biological sciences and medical sciences', 'Nature reviews. Molecular cell biology', 'Molecular biology reports', 'Current pharmaceutical design', 'Molecular neurodegeneration', 'Advances in protein chemistry and structural biology', 'PloS one', 'Acta medica portuguesa', 'Annual review of biophysics', 'Mechanisms of ageing and development', 'PloS one', 'Glia', 'Clinical interventions in aging', 'Experimental gerontology', 'BMJ open', 'Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie', 'Translational neurodegeneration', 'Current Alzheimer research', 'Journal of the American Heart Association', 'Current opinion in pharmacology', 'Journal of Zhejiang University. Science. B', 'Molecular neurobiology', 'Aging clinical and experimental research', 'Genes', "Journal of Alzheimer's disease : JAD", "Journal of Alzheimer's disease : JAD", 'Redox biology', 'Journal of molecular evolution', 'International journal of molecular sciences', 'International journal of molecular sciences', 'Comprehensive Physiology', 'Medicine', 'Brain : a journal of neurology', 'Neuroepidemiology', 'The journal of applied laboratory medicine', 'Neuro-degenerative diseases', 'Clinical epigenetics', 'Molecules and cells', 'Clinical & experimental optometry', 'Medical hypotheses', 'JAMA network open', 'Neurotoxicity research', 'Acta neuropathologica communications', 'Cerebral cortex (New York, N.Y. : 1991)', 'Aging clinical and experimental research', 'Health informatics journal', 'International journal of molecular sciences', 'Molecules (Basel, Switzerland)', 'Advances in experimental medicine and biology', 'Progress in neuro-psychopharmacology & biological psychiatry', 'Neuropharmacology', 'JAMA neurology', 'Current Alzheimer research', 'Clinical and experimental pharmacology & physiology', 'Trends in endocrinology and metabolism: TEM', 'Biochemical pharmacology', 'Handbook of clinical neurology', 'Handbook of clinical neurology', 'Handbook of clinical neurology', 'Handbook of clinical neurology', 'Handbook of clinical neurology', 'Handbook of clinical neurology', 'Journal of microbiology and biotechnology', 'The FEBS journal', 'Protein and peptide letters', 'Oxidative medicine and cellular longevity', 'Handbook of clinical neurology', 'Neurology', 'The Journal of steroid biochemistry and molecular biology', 'Journal of glaucoma', 'International review of psychiatry (Abingdon, England)', 'Sleep medicine', 'Nature communications', 'Trends in neurosciences', 'Neuropharmacology', 'Medicinal chemistry (Shariqah (United Arab Emirates))', 'Progress in molecular biology and translational science', 'Neurobiology of disease', 'Biochemical Society transactions', 'Journal of neuroinflammation', 'PloS one', 'Scientific reports', 'Oxidative medicine and cellular longevity', 'Mini reviews in medicinal chemistry', "The journal of prevention of Alzheimer's disease", 'The Journal of neuroscience : the official journal of the Society for Neuroscience', 'Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme', 'Canadian journal on aging = La revue canadienne du vieillissement', 'BMC public health', 'Scientific data', 'NeuroImage', 'Advances in neurobiology', 'Experimental gerontology', 'Experimental gerontology', 'Advances in experimental medicine and biology', 'Current Alzheimer research', 'International journal of molecular sciences', "Journal of Alzheimer's disease : JAD", 'International journal of molecular sciences', 'Current drug delivery', 'GeroScience', 'International journal of molecular sciences', 'Annals of nuclear medicine', 'Scientific reports', 'eLife', 'International review of neurobiology', 'BMC neurology', 'Journal of neuroinflammation', 'Neuropsychology, development, and cognition. Section B, Aging, neuropsychology and cognition', 'Aging clinical and experimental research', 'BMJ open', 'Redox biology', 'British journal of anaesthesia', 'Archives of gerontology and geriatrics', 'Frontiers in bioscience (Landmark edition)', 'European journal of medicinal chemistry', 'Aging clinical and experimental research', 'Aging clinical and experimental research', 'Human molecular genetics', 'The journals of gerontology. Series A, Biological sciences and medical sciences', 'Journal of neurochemistry', 'Brain : a journal of neurology', 'Ageing research reviews', 'Aging cell', 'Acta neuropsychiatrica', 'The Keio journal of medicine', 'JAMA network open', 'Scientific reports', 'Journal of neuroscience research', 'Cells', 'Cells', 'Cell stem cell', 'Neurobiology of aging', 'Cell and tissue banking', 'Medicina (Kaunas, Lithuania)', 'The Lancet. Neurology', "Journal of Parkinson's disease", 'Journal of psychosomatic research', 'The Annals of thoracic surgery', 'Biochimica et biophysica acta. Biomembranes', "Alzheimer's research & therapy", 'Ageing research reviews', 'PloS one', 'Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology', 'Surgical and radiologic anatomy : SRA', 'BMC psychiatry', 'Neuro-degenerative diseases', 'Nutrients', 'JCI insight', 'International journal of molecular sciences', 'Progress in molecular biology and translational science', 'Nutrients', 'International journal of molecular sciences', 'Neurobiology of aging', 'Ageing research reviews', 'Journal of neurochemistry', 'Journal of neurosurgery. Spine', 'Journal of neuroimmunology', 'Scientific reports', 'BMB reports', 'Analytical chemistry', 'Physiological reviews', 'Advances in experimental medicine and biology', 'Acta neuropathologica', 'Regenerative medicine', 'Molecular psychiatry', 'Dementia and geriatric cognitive disorders', 'Physiological reviews', "Journal of Alzheimer's disease : JAD", 'Trends in endocrinology and metabolism: TEM', 'Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry', 'Scientific reports', 'European journal of nuclear medicine and molecular imaging', "American journal of Alzheimer's disease and other dementias", 'Scientific reports', 'Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics', 'Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics', 'Journal of neurochemistry', 'Clinical reviews in allergy & immunology', 'Trends in molecular medicine', 'The Journal of biological chemistry', 'Australasian journal on ageing', 'Rejuvenation research', 'Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics', 'Minerva medica', 'International journal of molecular sciences', 'Acta dermatovenerologica Croatica : ADC', 'Clinical neuroradiology', 'A&A practice', 'Journal of neuro-oncology', 'JCI insight', 'Molecular psychiatry', 'Cell death & disease', 'Molecules (Basel, Switzerland)', 'Advances in nutrition (Bethesda, Md.)', 'The Journal of clinical investigation', 'Cells', "Journal of Huntington's disease", 'Dementia and geriatric cognitive disorders', 'The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques', 'Acta neurologica Belgica', 'Neurobiology of aging', "Journal of Alzheimer's disease : JAD", 'Medicine', 'Journal of medical systems', 'Arteriosclerosis, thrombosis, and vascular biology', 'International journal of molecular sciences', 'Mayo Clinic proceedings', 'GeroScience', 'Neurobiology of aging', 'Neurobiology of aging', 'Brain structure & function', 'Frontiers in immunology', 'Accounts of chemical research', 'Current neuropharmacology', 'International journal of molecular sciences', 'Neurologic clinics', 'Brain imaging and behavior', 'The Australian and New Zealand journal of psychiatry', 'BMJ open', 'International journal of molecular sciences', 'NeuroImage. Clinical', 'NeuroImage. Clinical', 'The journal of nutrition, health & aging', 'Current medicinal chemistry', 'Histology and histopathology', 'Frontiers in immunology', 'Oxidative medicine and cellular longevity', 'JAMA', 'Expert review of proteomics', 'Developmental psychology', 'Acta neuropsychiatrica', 'Connective tissue research', 'Cell transplantation', 'Ageing research reviews', 'Current HIV/AIDS reports', 'Neurotoxicity research', 'Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics', 'Zeitschrift fur Gerontologie und Geriatrie', 'Proceedings of the National Academy of Sciences of the United States of America', 'BMC musculoskeletal disorders', 'Acta neurochirurgica', 'GeroScience', 'Journal of cellular physiology', 'Neurobiology of disease', 'Maturitas', 'Acta neuropathologica', 'Neurobiology of aging', 'Experimental eye research', 'PloS one', 'Stem cell reviews and reports', 'PLoS biology', 'Parkinsonism & related disorders', 'Progress in neurobiology', "Journal of Alzheimer's disease : JAD", "Journal of Alzheimer's disease : JAD", 'Current Alzheimer research', 'Neurotoxicity research', 'Functional & integrative genomics', 'Nature medicine', 'Journal of the American Association of Nurse Practitioners', 'Neuropathology and applied neurobiology', 'Biomolecules', 'Neuropsychology', 'Clinical neurology and neurosurgery', 'Science translational medicine', 'Neuropsychologia', 'Aging', 'Neurobiology of aging', 'Cell reports', 'Clinical biochemistry', 'Journal of the neurological sciences', 'Restorative neurology and neuroscience', "Journal of Alzheimer's disease : JAD", 'European journal of neurology', 'Nature reviews. Neurology', 'International journal of molecular sciences', 'Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists', 'Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists', 'Pharmacological research', 'The British journal of radiology', 'Australasian journal on ageing', 'Aging cell', 'Journal of molecular modeling', 'Life sciences', 'Journal of cellular physiology', 'Autophagy', 'FEBS open bio', 'Current nutrition reports', 'Complementary therapies in medicine', 'International journal of molecular sciences', "Journal of Alzheimer's disease : JAD", 'Frontiers in immunology', 'Lipids in health and disease', 'Seminars in neurology', 'Journal of palliative medicine', 'Hong Kong medical journal = Xianggang yi xue za zhi', 'Geriatrie et psychologie neuropsychiatrie du vieillissement', 'British journal of anaesthesia', 'Oxidative medicine and cellular longevity', 'Journal of proteome research', 'Proceedings of the National Academy of Sciences of the United States of America', 'Pharmacological research', 'Cells', 'Stroke', 'NeuroImage. Clinical', 'Neuropsychology', 'Nordic journal of psychiatry', 'Central nervous system agents in medicinal chemistry', 'Turkish journal of medical sciences', 'Sub-cellular biochemistry', 'Sub-cellular biochemistry', 'Sub-cellular biochemistry', 'Genes, brain, and behavior', 'European radiology', 'Cortex; a journal devoted to the study of the nervous system and behavior', 'Developmental medicine and child neurology', "Journal of Alzheimer's disease : JAD", "Journal of Alzheimer's disease : JAD", "Journal of Alzheimer's disease : JAD", 'Indian journal of medical microbiology', 'Hellenic journal of nuclear medicine', 'Neuroscience', 'Geriatrics & gerontology international', 'Aging cell', 'Journal of neurovirology', 'Clinical interventions in aging', 'Metal ions in life sciences', 'Orthopaedics & traumatology, surgery & research : OTSR', 'Journal of neurotrauma', 'Neurology', 'Scientific reports', 'PloS one', 'Acta physiologica (Oxford, England)', 'Clinical neuropharmacology', 'Stem cell reports', 'Current Alzheimer research', 'Neuroscience letters', 'Molecular psychiatry', 'Current Alzheimer research', 'Journal of dental research', 'Acta biochimica Polonica', 'Nutrients', 'Current pharmaceutical design', 'Biochimica et biophysica acta. Molecular basis of disease', 'British journal of sports medicine', 'International journal of immunopathology and pharmacology', 'Journal of neurovirology', 'Journal of anesthesia', 'The Lancet. Neurology', 'International journal of molecular sciences', 'Sub-cellular biochemistry', "Journal of Alzheimer's disease : JAD", 'Scientific reports', 'PloS one', 'Cell reports', 'Glia', 'Reviews in the neurosciences', 'Neurology', 'International journal of molecular sciences', 'Journal of chemical neuroanatomy', 'International journal of molecular sciences', 'Journal of proteome research', 'Critical reviews in food science and nutrition', 'Amino acids', 'Cell death & disease', 'Food research international (Ottawa, Ont.)', 'Interdisciplinary sciences, computational life sciences', 'Acta neuropathologica', 'International journal of molecular sciences', 'Continuum (Minneapolis, Minn.)', 'Neurobiology of aging', 'Continuum (Minneapolis, Minn.)', 'Continuum (Minneapolis, Minn.)', 'Journal of neurology', 'Acta neuropathologica communications', 'Medicine', 'Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society', 'Molecular brain', 'Molecular neurobiology', 'Ageing research reviews', 'PloS one', 'PloS one', 'Alzheimer disease and associated disorders', 'Aging', 'Science translational medicine', 'Human brain mapping', 'Current opinion in neurology', 'Journal of neurovirology', 'Brain : a journal of neurology', 'Biogerontology', 'Cortex; a journal devoted to the study of the nervous system and behavior', 'NeuroImage', 'World neurosurgery', 'Neurology', 'Medicinal research reviews', 'Current pharmaceutical design', 'Alzheimer disease and associated disorders', 'International journal of neural systems', 'Journal of magnetic resonance imaging : JMRI', 'Journal of neuroscience research', 'The Journal of biological chemistry', 'Oxidative medicine and cellular longevity', 'Environment international', 'The Annals of thoracic surgery', 'Cortex; a journal devoted to the study of the nervous system and behavior', 'Neuroscience bulletin', 'Molecules (Basel, Switzerland)', 'Swiss medical weekly', 'ACS chemical neuroscience', "Journal of Alzheimer's disease : JAD", 'Oxidative medicine and cellular longevity', 'Neurobiology of aging', 'Rejuvenation research', 'Aging cell', 'The Journal of pathology', 'Cognitive and behavioral neurology : official journal of the Society for Behavioral and Cognitive Neurology', 'Gait & posture', 'Revista portuguesa de cardiologia', 'Nutrients', 'PloS one', 'Spine', 'BMC geriatrics', "Journal of Alzheimer's disease : JAD", 'Aging', 'Journal of proteomics', 'Nutricion hospitalaria', 'Neuroscience', 'Scientific reports', 'NeuroImage', 'The Journal of arthroplasty', 'Ageing research reviews', 'The journal of nutrition, health & aging', 'NeuroImage. Clinical', 'International journal of molecular sciences', 'Hormones (Athens, Greece)', 'Biochimica et biophysica acta. Molecular basis of disease', 'The Journal of endocrinology', 'AJNR. American journal of neuroradiology', 'Journal of the American Geriatrics Society', 'Handbook of clinical neurology', 'Human brain mapping', 'Neurobiology of aging', 'Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference', 'Physiological research', 'La Tunisie medicale', 'BMC neuroscience', 'Journal of the neurological sciences', 'JAMA neurology', 'Journal of sleep research', 'Clinical neuropathology', 'Drug discovery today', 'Journal of neuroinflammation', "Journal of Alzheimer's disease : JAD", 'The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry', "Alzheimer's research & therapy", 'Neurobiology of aging', 'Journal of cellular and molecular medicine', 'Ageing research reviews', 'Clinical nutrition ESPEN', 'Acta neuropathologica communications', 'Journal of affective disorders', 'Journal of nutritional science and vitaminology', 'Cell reports', 'Aging', 'Scientific reports', 'Nature genetics', 'Neuroendocrinology', 'Stroke', 'International journal of molecular sciences', 'The Journal of comparative neurology', 'Current Alzheimer research', 'European journal of medicinal chemistry', 'Advances in clinical chemistry', 'Aging', 'The American journal of case reports', 'International journal of neural systems', 'The Journal of the American Academy of Orthopaedic Surgeons', 'Journal of cellular and molecular medicine', 'JAMA neurology', 'Scientific reports', 'Journal of molecular endocrinology', 'Human molecular genetics', 'The Lancet. Neurology', 'Current HIV research', 'FASEB journal : official publication of the Federation of American Societies for Experimental Biology', 'The American journal of pathology', 'Nature reviews. Neuroscience', 'Andrologia', 'Nature neuroscience', 'Australian occupational therapy journal', 'Nature neuroscience', 'Rejuvenation research', 'Human brain mapping', 'The journals of gerontology. Series A, Biological sciences and medical sciences', 'Australian health review : a publication of the Australian Hospital Association', 'Experimental neurology', 'Scientific reports', 'Brain research bulletin', 'Histochemistry and cell biology', 'Brain research bulletin', 'Advances in experimental medicine and biology', 'Advances in experimental medicine and biology', 'Neurology', 'Acta neurologica Scandinavica', "Alzheimer's research & therapy", 'Molecular genetics & genomic medicine', 'Nature communications', 'Journal of neurochemistry', 'Annual review of genetics', "Alzheimer's & dementia : the journal of the Alzheimer's Association", 'Fish & shellfish immunology', 'PLoS genetics', 'Journal of neuroinflammation', 'JCI insight', 'The Analyst', 'DNA repair', 'Geriatrie et psychologie neuropsychiatrie du vieillissement', 'Journal of virology', 'Brain research bulletin', "Journal of Alzheimer's disease : JAD", 'PLoS biology', 'Cell', 'Molecular neurobiology', 'PloS one', 'Journal of neuroscience methods', 'Current medicinal chemistry', 'Molecular neurobiology', 'International journal of molecular sciences', 'Aging cell', 'The journals of gerontology. Series A, Biological sciences and medical sciences', 'Biochemical pharmacology', 'Neuroscience research', 'Behavioural brain research', 'Nutrients', 'Journal of neural transmission (Vienna, Austria : 1996)', 'Current Alzheimer research', 'British journal of pharmacology', 'The Lancet. Neurology', 'Molecular neurodegeneration', 'Physiological measurement', 'Glycoconjugate journal', 'Progress in neurobiology', 'Experimental gerontology', 'International review of cell and molecular biology', 'Progress in molecular biology and translational science', 'Experimental gerontology', 'PloS one', 'Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology', 'Neurotoxicity research', "Journal of Alzheimer's disease : JAD", 'Parkinsonism & related disorders', 'ACS chemical neuroscience', 'Journal of internal medicine', 'Cell death & disease', 'Molecular neurobiology', 'Molecular neurodegeneration', 'Mechanisms of ageing and development', 'Seizure', "Journal of Alzheimer's disease : JAD", 'PLoS medicine', 'World journal of gastroenterology', 'Essays in biochemistry', 'Vitamins and hormones', 'Vitamins and hormones', 'Current medicinal chemistry', 'Biochemical Society transactions', 'Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics', 'Experimental gerontology', 'BMC geriatrics', "Journal of Alzheimer's disease : JAD", 'Journal of chromatography. A', 'NeuroImage. Clinical', 'Medicine', 'Journal of neural transmission (Vienna, Austria : 1996)', 'IEEE journal of biomedical and health informatics', 'Journal of biomedical science', 'The journals of gerontology. Series A, Biological sciences and medical sciences', 'Scientific reports', 'Nutricion hospitalaria', 'Clinical nutrition (Edinburgh, Scotland)', 'Proceedings of the National Academy of Sciences of the United States of America', 'Neuroscience letters', 'Biomolecules', 'BMJ case reports', 'Advances in experimental medicine and biology', 'Human brain mapping', 'Clinical rheumatology', 'Journal of neuropathology and experimental neurology', 'Mechanisms of ageing and development', 'Journal of experimental & clinical cancer research : CR', 'Journal of neurosurgical sciences', "Alzheimer's & dementia : the journal of the Alzheimer's Association", 'Acta neuropathologica', 'The oncologist', 'The Journal of neuroscience : the official journal of the Society for Neuroscience', 'Neuropharmacology', 'Indian journal of public health', 'Brain : a journal of neurology', 'Neurology', 'Molecular psychiatry', 'Current nutrition reports', 'Handbook of clinical neurology', 'The International journal of neuroscience', 'Cell death & disease', 'ACS chemical biology', 'Geriatrie et psychologie neuropsychiatrie du vieillissement', 'Cell reports', 'Cell transplantation', 'Journal of molecular modeling', 'Cell transplantation', "Journal of Alzheimer's disease : JAD", "Journal of Alzheimer's disease : JAD", "Alzheimer's research & therapy", 'Journal of medical imaging and radiation oncology', 'Oxidative medicine and cellular longevity', 'Microcirculation (New York, N.Y. : 1994)', 'Gerontology', 'Nature communications', 'Molecular neurobiology', 'Fungal biology', 'JAMA neurology', 'NeuroImage', 'Nutrients', 'PloS one', 'Molecular neurodegeneration', 'Psychological assessment', 'Cellular and molecular life sciences : CMLS', 'Molecular neurodegeneration', 'Cell', 'Current drug targets', 'CNS neuroscience & therapeutics', 'Scientific reports', 'FASEB journal : official publication of the Federation of American Societies for Experimental Biology', 'Cell reports', 'Journal of molecular endocrinology', 'Clinical interventions in aging', 'The Lancet. Neurology', 'World neurosurgery', 'BMC cardiovascular disorders', "Journal of Alzheimer's disease : JAD", 'International journal of molecular sciences', 'Neurologia i neurochirurgia polska', 'Clinical neurology and neurosurgery', 'Neurobiology of aging', 'Journal of neuropsychology', "Alzheimer's research & therapy", 'Biochemistry and cell biology = Biochimie et biologie cellulaire', 'Evidence-based mental health', 'Journal of chemical neuroanatomy', 'International journal of stroke : official journal of the International Stroke Society', 'Advanced drug delivery reviews', 'Neurobiology of aging', 'The Kaohsiung journal of medical sciences', 'Neurology', "Alzheimer's & dementia : the journal of the Alzheimer's Association", 'Rejuvenation research', 'Nucleus (Austin, Tex.)', 'Antioxidants & redox signaling', 'The Analyst', 'Neurobiology of disease', 'The FEBS journal', 'Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver', 'Biochemistry. Biokhimiia', 'Biotechnology letters', "Alzheimer's & dementia : the journal of the Alzheimer's Association", 'Mechanisms of ageing and development', 'Evidence-based mental health', 'Frontiers in immunology', 'Journal of internal medicine', 'Inflammation research : official journal of the European Histamine Research Society ... [et al.]', 'Mechanisms of ageing and development', 'Redox biology', "Journal of Alzheimer's disease : JAD", 'Pharmacology & therapeutics', 'The American journal of pathology', 'The American journal of case reports', 'The Journal of biological chemistry', "Journal of Alzheimer's disease : JAD", 'International journal of molecular sciences', "Journal of Alzheimer's disease : JAD", "Alzheimer's research & therapy", 'Current neurovascular research', 'Scientific reports', 'Mechanisms of ageing and development', 'Clinical interventions in aging', 'Neuroscience and biobehavioral reviews', 'JAMA neurology', 'The Journal of nutritional biochemistry', 'Current opinion in neurobiology', 'Cell death and differentiation', 'Brain : a journal of neurology', 'Pharmacology & therapeutics', 'Medical science monitor : international medical journal of experimental and clinical research', "Alzheimer's research & therapy", 'Bioinformatics (Oxford, England)', "Journal of Alzheimer's disease : JAD", 'Journal of cellular and molecular medicine', 'The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry', 'Journal of chemical neuroanatomy', 'Journal of neurosurgery', 'Journal of nuclear medicine : official publication, Society of Nuclear Medicine', 'Handbook of clinical neurology', 'Handbook of clinical neurology', 'British journal of neurosurgery', 'Human brain mapping', "Journal of Alzheimer's disease : JAD", 'Future medicinal chemistry', 'Experimental gerontology', 'Progress in cardiovascular diseases', 'Neuropharmacology', 'Journal of chemical neuroanatomy', 'Ideggyogyaszati szemle', 'Journal of neurology, neurosurgery, and psychiatry', 'Neurobiology of aging', 'Neuroscience letters', 'Ageing research reviews', 'Critical reviews in food science and nutrition', 'Scientific reports', "Journal of Alzheimer's disease : JAD", 'Methods in molecular biology (Clifton, N.J.)', 'Neuroscience', 'Antioxidants & redox signaling', 'Tissue & cell', 'Gait & posture', 'The American journal of medicine', 'Cell biology international', 'JCI insight', 'Nature communications', 'Journal of radiation research', 'Journal of photochemistry and photobiology. B, Biology', 'The Journal of frailty & aging', 'Chemico-biological interactions', 'The journal of hand surgery Asian-Pacific volume', 'Experimental gerontology', 'Neurobiology of aging', 'Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research', 'Current drug metabolism', 'Molecular neurobiology', 'Neuropathology and applied neurobiology', 'International journal of molecular sciences', 'Proceedings of the National Academy of Sciences of the United States of America', 'Journal of applied physiology (Bethesda, Md. : 1985)', 'Molecular neurobiology', 'Journal of molecular neuroscience : MN', 'Acta bio-medica : Atenei Parmensis', 'Echocardiography (Mount Kisco, N.Y.)', 'The British journal of nutrition', 'Methods in molecular biology (Clifton, N.J.)', 'Molecular and cellular neurosciences', 'Human brain mapping', 'Advanced drug delivery reviews', "Journal of Alzheimer's disease : JAD", 'Clinical neurology and neurosurgery', "Alzheimer's & dementia : the journal of the Alzheimer's Association", 'Journal of the American Geriatrics Society', 'British journal of pharmacology', 'Science signaling', 'Aging', 'Frontiers in neural circuits', 'Neuropharmacology', 'Brain : a journal of neurology', 'Neurocase', 'The Journal of neuroscience : the official journal of the Society for Neuroscience', 'Circulation research', 'International journal of geriatric psychiatry', 'Frontiers in bioscience (Elite edition)', 'Medicina intensiva', 'Journal of visualized experiments : JoVE', 'Critical reviews in eukaryotic gene expression', 'BMJ open', 'Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology', 'World neurosurgery', 'Experimental gerontology', 'Canadian journal on aging = La revue canadienne du vieillissement', 'Journal of molecular neuroscience : MN', 'JNMA; journal of the Nepal Medical Association', 'Journal of biological regulators and homeostatic agents', "Journal of Huntington's disease", 'Heart, lung & circulation', 'Annals of neurology', 'Nature reviews. Neurology', 'Current topics in medicinal chemistry', 'International psychogeriatrics', 'The Proceedings of the Nutrition Society', 'Best practice & research. Clinical rheumatology', 'Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing', 'Science (New York, N.Y.)', 'International journal of molecular sciences', 'Nutrients', 'Current neuropharmacology', 'Mediators of inflammation', 'Journal of molecular recognition : JMR', 'NeuroImage', 'Methods in molecular biology (Clifton, N.J.)', 'Current protein & peptide science', "The journal of prevention of Alzheimer's disease", 'Cortex; a journal devoted to the study of the nervous system and behavior', 'Human brain mapping', 'Brain : a journal of neurology', 'Journal of integrative neuroscience', 'Journal of physiology and pharmacology : an official journal of the Polish Physiological Society', 'Current neurovascular research', 'Acta neurologica Scandinavica', 'Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia', 'eLife', 'International journal of molecular sciences', 'FEBS letters', 'Oxidative medicine and cellular longevity', 'Molecular neurodegeneration', 'Experimental gerontology', 'Neuroscience letters', 'CNS drugs', 'Archives of gerontology and geriatrics', 'The neurologist', 'Neurology', 'The journal of nutrition, health & aging', 'Acta bio-medica : Atenei Parmensis', 'NeuroImage', 'Journal of orthopaedic research : official publication of the Orthopaedic Research Society', 'Stem cell research & therapy', 'Spine', 'Immunological investigations', 'The International journal of neuroscience', 'Brain : a journal of neurology', 'Acta neuropathologica', 'American journal of human genetics', 'Computer methods and programs in biomedicine', 'Nucleic acids research', 'Nutrients', 'BMC geriatrics', "Journal of Alzheimer's disease : JAD", 'Current opinion in clinical nutrition and metabolic care', 'Laboratory investigation; a journal of technical methods and pathology', 'Cellular and molecular life sciences : CMLS', 'Neurology', 'Journal of neural transmission (Vienna, Austria : 1996)', 'Aging cell', 'Annals of neurology', 'ACS chemical neuroscience', 'Antioxidants & redox signaling', 'PloS one', 'Ageing research reviews', 'IEEE transactions on bio-medical engineering', 'Biochimica et biophysica acta. Molecular basis of disease', 'Handbook of clinical neurology', 'Brain pathology (Zurich, Switzerland)', 'Acta neurologica Belgica', 'Neurobiology of disease', 'Molecular neurodegeneration', 'Neurobiology of aging', 'Advances in neurobiology', 'JBJS reviews', 'Aging cell', 'NeuroImage', 'European archives of psychiatry and clinical neuroscience', 'European journal of radiology', 'Biochemistry. Biokhimiia', 'Human molecular genetics', 'PloS one', 'Clinical interventions in aging', "Journal of Alzheimer's disease : JAD", 'European journal of neurology', 'Ageing research reviews', 'Oxidative medicine and cellular longevity', 'Biochemical and biophysical research communications', 'Journal of cellular physiology', 'Molecular neurobiology', 'Neurology', 'Nature communications', 'Prostaglandins, leukotrienes, and essential fatty acids', 'Advances in experimental medicine and biology', 'Neuron', 'Human brain mapping', 'Scientific reports', 'The Journal of neuroscience : the official journal of the Society for Neuroscience', 'Current Alzheimer research', 'Scientific reports', 'FASEB journal : official publication of the Federation of American Societies for Experimental Biology', 'Advances in experimental medicine and biology', 'International journal of molecular sciences', 'Lancet (London, England)', 'Advances in experimental medicine and biology', 'Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association', 'Journal of neuroimmunology', 'Autophagy', 'Molecular brain', 'PloS one', 'Experimental neurology', 'PloS one', 'PloS one', 'Current medicinal chemistry', "Journal of Alzheimer's disease : JAD", 'Aging', 'Aging cell', 'Mutation research', "Journal of Alzheimer's disease : JAD", "Journal of Alzheimer's disease : JAD", "Journal of Alzheimer's disease : JAD", 'Current neurovascular research', 'Biochemical and biophysical research communications', 'Advances in nutrition (Bethesda, Md.)', 'The spine journal : official journal of the North American Spine Society', 'Indian journal of pharmacology', 'Journal of neurosurgical sciences', "Journal of Alzheimer's disease : JAD", 'Biochimica et biophysica acta. Reviews on cancer', 'Clinics in geriatric medicine', 'PloS one', 'The International journal of artificial organs', 'AJNR. American journal of neuroradiology', 'Mutation research. Genetic toxicology and environmental mutagenesis', 'The journal of the Royal College of Physicians of Edinburgh', 'FP essentials', 'Nature neuroscience', "Journal of Alzheimer's disease : JAD", 'Clinical epigenetics', 'CNS neuroscience & therapeutics', 'Molecular neurobiology', 'NeuroImage', 'The American journal of Chinese medicine', 'Prion', 'Pakistan journal of pharmaceutical sciences', 'Sensors (Basel, Switzerland)', 'Cellular and molecular life sciences : CMLS', 'American journal of medical genetics. Part A', 'Scientific reports', 'Scientific reports', 'Neuro-degenerative diseases', 'Neuropathology and applied neurobiology', 'Geriatrie et psychologie neuropsychiatrie du vieillissement', 'Neuroscience', 'Neuropharmacology', 'Journal of the International Society of Sports Nutrition', 'Aging cell', 'Brain imaging and behavior', 'Brain pathology (Zurich, Switzerland)', "Journal of Alzheimer's disease : JAD", "Journal of Alzheimer's disease : JAD", 'PloS one', 'New biotechnology', 'BMC neuroscience', 'Medical hypotheses', 'Human brain mapping', 'International review of neurobiology', 'International journal of medical sciences', "Journal of Alzheimer's disease : JAD", 'Current Alzheimer research', 'Annals of neurology', 'Biochemical pharmacology', 'Chemical senses', 'Materials science & engineering. C, Materials for biological applications', 'Journal of genetics and genomics = Yi chuan xue bao', 'Tissue engineering. Part B, Reviews', 'Journal of neural transmission (Vienna, Austria : 1996)', 'Nutrition research reviews', "Journal of Alzheimer's disease : JAD", 'Nutrition reviews', 'Journal of neuropathology and experimental neurology', 'JAMA neurology', 'Annual review of biochemistry', 'Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association', 'Trends in molecular medicine', 'Medical hypotheses', 'Methods in molecular biology (Clifton, N.J.)', 'AIDS (London, England)', 'Scientific reports', 'NeuroImage. Clinical', 'Parkinsonism & related disorders', 'The Lancet. Neurology', 'Practical neurology', 'BMB reports', 'Neuropathology and applied neurobiology', 'Human molecular genetics', 'The journals of gerontology. Series A, Biological sciences and medical sciences', 'Journal of the American Geriatrics Society', 'Nature medicine', 'PloS one', 'The Journal of laryngology and otology', 'Assay and drug development technologies', 'JAMA neurology', 'Neuroscience letters', 'Postepy higieny i medycyny doswiadczalnej (Online)', 'Acta neurologica Belgica', 'Health policy (Amsterdam, Netherlands)', 'Cold Spring Harbor perspectives in medicine', 'The Clinical neuropsychologist', 'European archives of psychiatry and clinical neuroscience', 'Neuron', "Alzheimer's & dementia : the journal of the Alzheimer's Association", 'Cell reports', 'Drug design, development and therapy', 'PLoS medicine', 'The Journal of biological chemistry', 'Acta neurologica Scandinavica', 'Mutagenesis', 'Neuroscience letters', 'International journal of molecular sciences', 'Yonsei medical journal', 'Current pharmaceutical design', 'Biochemistry. Biokhimiia', 'GeroScience', 'GeroScience', 'Current neuropharmacology', 'The Journal of neuroscience : the official journal of the Society for Neuroscience', 'Current Alzheimer research', 'Comprehensive psychiatry', 'Environmental geochemistry and health', 'Journal of nuclear medicine : official publication, Society of Nuclear Medicine', 'Expert review of clinical pharmacology', 'Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism', 'Journal of neurology', 'Oxidative medicine and cellular longevity', 'Chemico-biological interactions', "Alzheimer's research & therapy", 'Experimental brain research', 'NeuroImage', 'Progress in molecular biology and translational science', 'Progress in molecular biology and translational science', 'Progress in molecular biology and translational science', 'PloS one', 'Neuroscience letters', 'Nature', 'Current opinion in genetics & development', 'Neurology', 'Environmental research', "Journal of Alzheimer's disease : JAD", "Journal of Alzheimer's disease : JAD", 'Journal of photochemistry and photobiology. B, Biology', 'Neuropharmacology', 'BioMed research international', 'Scientific reports', 'Toxicology and applied pharmacology', 'Neurogenetics', 'Trends in molecular medicine', 'Current Alzheimer research', 'BMJ open', 'Human molecular genetics', 'Cell cycle (Georgetown, Tex.)', 'Fly', 'Journal of neuropathology and experimental neurology', 'Nutrients', 'Ortopedia, traumatologia, rehabilitacja', 'Aging clinical and experimental research', 'Acta neuropathologica communications', 'FASEB journal : official publication of the Federation of American Societies for Experimental Biology', 'The Analyst', 'Toxicology in vitro : an international journal published in association with BIBRA', 'NeuroImage', 'Bratislavske lekarske listy', 'Acta neuropathologica communications', 'Current pharmaceutical design', 'Omics : a journal of integrative biology', 'Parkinsonism & related disorders', 'PloS one', 'Journal of neurovirology', 'Current environmental health reports', 'Seminars in hematology', 'CNS & neurological disorders drug targets', 'Redox biology', 'Hippocampus', 'Free radical biology & medicine', 'Current opinion in genetics & development', 'Wiley interdisciplinary reviews. Systems biology and medicine', 'Trends in endocrinology and metabolism: TEM', 'Redox biology', 'Journal of visualized experiments : JoVE', "Journal of Alzheimer's disease : JAD", 'Current topics in developmental biology', 'The journal of contemporary dental practice', 'Journal of neurology', 'Dysphagia', 'Journal of clinical densitometry : the official journal of the International Society for Clinical Densitometry', 'Oncotarget', 'Neuropsychology', 'Histochemistry and cell biology', 'Expert opinion on drug metabolism & toxicology', 'Scientific reports', 'Pflugers Archiv : European journal of physiology', 'Seminars in nuclear medicine', 'Cell biology and toxicology', 'Free radical biology & medicine', 'Geriatrie et psychologie neuropsychiatrie du vieillissement', 'Expert review of proteomics', 'BMC genomics', 'Chemical research in toxicology', 'Cerebrovascular diseases (Basel, Switzerland)', 'Current pharmaceutical design', 'Translational psychiatry', 'Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association', 'Brain : a journal of neurology', 'Acta orthopaedica', 'Free radical biology & medicine', 'Dementia and geriatric cognitive disorders', 'Cold Spring Harbor molecular case studies', 'Human genetics', 'Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association', 'Glia', "Journal of Alzheimer's disease : JAD", 'European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society', 'Molecular neurobiology', 'Ageing research reviews', 'Nature communications', 'Journal of the American Geriatrics Society', 'Journal of clinical and experimental neuropsychology', 'Ageing research reviews', 'Brain pathology (Zurich, Switzerland)', 'Journal of neuroinflammation', 'Brain pathology (Zurich, Switzerland)', 'Journal of neurosurgery. Spine', 'Nutrients', 'NeuroImage', 'Experimental neurology', 'Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie', 'Nature', 'Nature', 'Biology direct', 'PloS one', 'Genetics and molecular research : GMR', 'Neurobiology of disease', 'PloS one', 'Molecular brain', 'Current drug targets', 'Danish medical journal', 'Healthcare quarterly (Toronto, Ont.)', 'Acta cytologica', 'CNS & neurological disorders drug targets', 'Biogerontology', 'Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology', 'Molecular neurobiology', 'Neurobiology of aging', 'Proceedings of the National Academy of Sciences of the United States of America', 'Current neuropharmacology', 'Current Alzheimer research', 'Molecular medicine reports', 'Journal of structural biology', 'FEBS letters', 'BMC neurology', 'Expert review of neurotherapeutics', 'Journal of postgraduate medicine', 'Current Alzheimer research', 'The FEBS journal', 'Behavioural brain research', 'Molecular and cellular biochemistry', 'Neurology', 'Behavioural brain research', 'Neuroscience letters', 'Neurobiology of aging', 'ACS chemical biology', 'International journal of dental hygiene', 'Expert opinion on therapeutic patents', 'The Journal of pathology', 'Current pharmaceutical design', 'Essays in biochemistry', 'Journal of palliative medicine', 'Journal of neuroimmunology', "Alzheimer's research & therapy", 'Experimental & molecular medicine', 'PloS one', 'Drug design, development and therapy', 'Journal of clinical and experimental neuropsychology', 'Clinical immunology (Orlando, Fla.)', "Journal of Alzheimer's disease : JAD", 'Current aging science', 'Archives of gerontology and geriatrics', 'Advances in neurobiology', 'Brain structure & function', 'eLife', 'The American journal of pathology', 'Disease models & mechanisms', 'Journal of psychiatry & neuroscience : JPN', 'Advances in nutrition (Bethesda, Md.)', 'International journal of geriatric psychiatry', 'PloS one', 'BMC neurology', 'Current pharmaceutical design', 'Developmental neurobiology', 'Wiley interdisciplinary reviews. Systems biology and medicine', 'Molecular neurobiology', 'Molecular neurobiology', 'Acta neuropathologica communications', 'Tissue barriers', 'BioFactors (Oxford, England)', 'Acta neuropathologica', 'Biochemical and biophysical research communications', 'Neurology', 'JAMA neurology', 'JAMA neurology', 'Behavioural brain research', 'Cell death & disease', 'Experimental brain research', 'Scientific reports', 'Biomolecular concepts', 'The Yale journal of biology and medicine', 'Periodontology 2000', 'Journal of visualized experiments : JoVE', 'Journal of molecular neuroscience : MN', 'Brain research bulletin', 'Brain pathology (Zurich, Switzerland)', 'Life sciences', 'Wiadomosci lekarskie (Warsaw, Poland : 1960)', 'Molecular medicine reports', 'Journal of the mechanical behavior of biomedical materials', 'Ageing research reviews', 'Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi', 'The European journal of neuroscience', 'Neurobiology of aging', 'Neurotoxicology', 'Biochemical and biophysical research communications', 'Geriatric nursing (New York, N.Y.)', 'Mitochondrion', "Alzheimer's & dementia : the journal of the Alzheimer's Association", 'BMC geriatrics', 'Current biology : CB', 'Neurology', 'Molecular neurodegeneration', 'Antioxidants & redox signaling', 'Free radical biology & medicine', 'NeuroImage', 'European cells & materials', 'Ageing research reviews', 'NeuroImage', 'Mechanisms of ageing and development', 'Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace', "Journal of Alzheimer's disease : JAD", 'Life sciences', 'Experimental cell research', 'Ageing research reviews', 'The Clinical neuropsychologist', 'Free radical research', "Journal of Alzheimer's disease : JAD", 'Nature reviews. Neurology', 'Current Alzheimer research', 'Protoplasma', 'Current Alzheimer research', 'Mini reviews in medicinal chemistry', 'Cellular and molecular life sciences : CMLS', 'Neuroscience and biobehavioral reviews', 'CNS drugs', 'Glycoconjugate journal', 'Brain : a journal of neurology', 'Microscopy research and technique', 'Brain research bulletin', 'Radiology', 'Current neuropharmacology', 'Journal of cellular biochemistry', "American journal of Alzheimer's disease and other dementias", 'Neuropathology and applied neurobiology', 'Pharmacology & therapeutics', 'Journal of neuropathology and experimental neurology', 'Acta neuropathologica', 'Neuroscience', 'International journal of geriatric psychiatry', 'Human mutation', 'Cellular and molecular life sciences : CMLS', 'Molecular neurobiology', 'Cold Spring Harbor perspectives in medicine', 'Molecular biology of the cell', 'International journal of surgery (London, England)', 'Drug and chemical toxicology', 'International journal of molecular medicine', 'Genome biology', 'Neurosurgical focus', 'South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde', 'Neuro-degenerative diseases', 'Journal of tissue engineering and regenerative medicine', 'Proteomics. Clinical applications', 'Nursing standard (Royal College of Nursing (Great Britain) : 1987)', 'Osteoarthritis and cartilage', 'Stem cell reviews and reports', 'Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society', 'PloS one', 'Medicinal research reviews', 'CNS & neurological disorders drug targets', "Journal of Alzheimer's disease : JAD", 'Physical biology', "Journal of Alzheimer's disease : JAD", "Journal of Alzheimer's disease : JAD", 'Trends in pharmacological sciences', 'Scientific reports', 'Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS)', "Alzheimer's & dementia : the journal of the Alzheimer's Association", 'Aging clinical and experimental research', 'Annual review of biochemistry', 'Mammalian genome : official journal of the International Mammalian Genome Society', 'Vitamins and hormones', 'Genome biology', 'Molecular neurodegeneration', "Alzheimer's research & therapy", 'Molecular neurodegeneration', 'Current aging science', 'Neuropsychology', 'Molecular medicine reports', 'Ageing research reviews', "Journal of Alzheimer's disease : JAD", 'The British journal of nutrition', 'The journals of gerontology. Series A, Biological sciences and medical sciences', 'Cell stress & chaperones', 'Expert review of neurotherapeutics', 'Proceedings of the National Academy of Sciences of the United States of America', 'Neurotoxicology', 'Neurotoxicology', 'Instructional course lectures', 'Advances in cancer research', 'Free radical biology & medicine', 'Nutrition reviews', "Journal of Alzheimer's disease : JAD", 'Molecular neurobiology', 'Biochimica et biophysica acta', 'International psychogeriatrics', 'CNS neuroscience & therapeutics', 'NeuroImage', 'Trends in neurosciences', 'Current medicinal chemistry', 'Molecular and cellular biology', "Journal of Alzheimer's disease : JAD", "Journal of Alzheimer's disease : JAD", "Journal of Alzheimer's disease : JAD", 'Journal of neurovirology', 'Trends in endocrinology and metabolism: TEM', 'Sleep', 'Journal of psychiatric research', 'EMBO reports', 'International journal of molecular sciences', 'Neurobiology of aging', 'Current Alzheimer research', 'Biological research', 'Neurology', 'Aging cell', 'Oxidative medicine and cellular longevity', 'Deutsches Arzteblatt international', 'Drug development research', 'Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie', "Journal of Alzheimer's disease : JAD", 'Neural plasticity', 'Medical hypotheses', 'Oxidative medicine and cellular longevity', 'The Tohoku journal of experimental medicine', 'Academic radiology', 'Veterinary pathology', 'Veterinary pathology', 'Veterinary pathology', 'Applied immunohistochemistry & molecular morphology : AIMM', 'Advances in gerontology = Uspekhi gerontologii', 'Biochimie', 'Seminars in cell & developmental biology', 'Journal of neuropathology and experimental neurology', 'Central European journal of public health', 'Current opinion in psychiatry', 'Biological psychiatry', 'Genome medicine', 'Experimental gerontology', 'Movement disorders : official journal of the Movement Disorder Society', 'Mass spectrometry reviews', 'The Journal of neuroscience : the official journal of the Society for Neuroscience', 'Biomolecules', 'Journal of neurochemistry', 'Brain pathology (Zurich, Switzerland)', 'Magnetic resonance in medicine', 'Molecular neurobiology', 'Turkish journal of medical sciences', 'Turkish journal of medical sciences', 'Neuro-degenerative diseases', 'BioEssays : news and reviews in molecular, cellular and developmental biology', 'Computer methods and programs in biomedicine', 'Acta neuropathologica', 'PLoS computational biology', 'Swiss medical weekly', 'Biochimie', 'International journal of molecular sciences', 'Nutrients', 'Neurotoxicology', 'Biochimica et biophysica acta', "Journal of Alzheimer's disease : JAD", 'PloS one', 'Journal of neurochemistry', 'Proceedings of the National Academy of Sciences of the United States of America', 'Annali di igiene : medicina preventiva e di comunita', 'Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism', 'The Journal of neuroscience : the official journal of the Society for Neuroscience', 'International journal of cardiology', 'Molecular brain', 'Cardiovascular research', 'Annual review of biomedical engineering', 'Biochemistry. Biokhimiia', 'Molecules (Basel, Switzerland)', 'Medicine', 'Experimental gerontology', 'Neurosurgical focus', 'Brain : a journal of neurology', 'Age (Dordrecht, Netherlands)', 'Neuromolecular medicine', 'Clinical interventions in aging', 'The Journal of neuroscience : the official journal of the Society for Neuroscience', 'Stem cells translational medicine', 'BMJ case reports', 'PloS one', 'Journal of nutritional science and vitaminology', 'The Lancet. Neurology', 'JAMA neurology', 'Brain research', 'Neuropsychology review', 'Acta neuropathologica', 'AJNR. American journal of neuroradiology', 'European journal of medicinal chemistry', 'BioMed research international', 'Nuclear medicine communications', 'Acta neuropathologica communications', 'Expert reviews in molecular medicine', 'Neurochemistry international', 'Ageing research reviews', 'European journal of neurology', 'Neuroscience letters', 'Neurology', 'The Journal of the American Academy of Orthopaedic Surgeons', 'Nature cell biology', 'Acta neuropathologica', 'PloS one', 'The Journal of neuroscience : the official journal of the Society for Neuroscience', 'Mechanisms of ageing and development', 'Current psychiatry reports', 'Progress in molecular biology and translational science', 'PLoS genetics', 'The Journal of biological chemistry', 'Biogerontology', 'The Journal of neuroscience : the official journal of the Society for Neuroscience', 'PloS one', 'Expert review of clinical pharmacology', 'Progress in neurobiology', 'Journal of cell science', 'Genetics', 'The Journal of pathology', "Journal of Alzheimer's disease : JAD", 'Trends in neurosciences', 'Neurochemical research', 'Metallomics : integrated biometal science', 'JAMA neurology', 'Neurobiology of aging', 'Brain : a journal of neurology', 'Acta neurologica Scandinavica', 'PloS one', 'Current neurology and neuroscience reports', 'Aging clinical and experimental research', 'Psychiatria Danubina', 'Expert opinion on biological therapy', 'Molecular genetics and metabolism', 'Biochimica et biophysica acta', "Journal of Alzheimer's disease : JAD", "Journal of Alzheimer's disease : JAD", 'Journal of the American College of Nutrition', 'Current opinion in neurobiology', 'Development (Cambridge, England)', 'PloS one', 'Current Alzheimer research', 'Brain structure & function', 'Neurochemistry international', 'Cold Spring Harbor perspectives in medicine', 'Neurosurgery', 'Neurosurgery', 'Neurosurgery', 'Neurosurgery', 'Neurosurgery', 'Physiological reviews', 'Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer', 'Human molecular genetics', 'The Journal of biological chemistry', 'Journal of neurosurgical anesthesiology', 'Journal of cellular biochemistry', 'Mutation research', 'European journal of medicinal chemistry', 'Age (Dordrecht, Netherlands)', 'Brain research bulletin', 'Neurobiology of aging', 'Current opinion in cell biology', 'Molecular aspects of medicine', 'Medicine and law', 'Journal of neurology', 'JAMA psychiatry', 'The International journal of neuroscience', 'The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry', 'Neuropsychology review', 'Cell', 'PloS one', 'International review of neurobiology', 'International review of neurobiology', 'NMR in biomedicine', 'Journal of clinical laboratory analysis', 'Journal of neuroscience research', 'BioMed research international', 'Acta neuropathologica', 'Molecular brain', 'CNS & neurological disorders drug targets', 'Molecular neurodegeneration', 'International journal of medical sciences', 'Neuroimmunomodulation', 'NeuroImage', 'European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society', 'Neuroscience', 'NeuroImage', 'Journal of neurology', 'Neurobiology of disease', 'Human molecular genetics', 'Oxidative medicine and cellular longevity', 'Food & function', 'Methods in molecular biology (Clifton, N.J.)', 'Methods in molecular biology (Clifton, N.J.)', 'Methods in molecular biology (Clifton, N.J.)', 'Journal of the International Neuropsychological Society : JINS', 'Aging clinical and experimental research', 'Auris, nasus, larynx', 'Experimental eye research', 'International journal of molecular sciences', 'NeuroImage', 'Nature', 'Rejuvenation research', 'Cellular and molecular neurobiology', 'Acta neuropathologica communications', 'Sleep medicine', 'Pain', 'Neurology', 'Age (Dordrecht, Netherlands)', 'Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism', 'Acta neurochirurgica', 'Neuro-degenerative diseases', 'Biochemical and biophysical research communications', 'Nature medicine', 'Oncotarget', 'Biochimica et biophysica acta', 'Current aging science', 'Assistive technology : the official journal of RESNA', 'Arquivos brasileiros de cardiologia', 'Hormones and behavior', 'Free radical biology & medicine', 'Neurobiology of disease', 'Gene', 'Infection', 'Molecular medicine reports', 'PloS one', 'Biochemical and biophysical research communications', "Alzheimer's & dementia : the journal of the Alzheimer's Association", 'Brain and behavior', 'Journal of neuropathology and experimental neurology', 'Journal of neuropathology and experimental neurology', 'Current opinion in cell biology', 'Oxidative medicine and cellular longevity', "Alzheimer's & dementia : the journal of the Alzheimer's Association", 'The Journal of physiology', 'Current topics in medicinal chemistry', 'NMR in biomedicine', 'BMC complementary and alternative medicine', 'Neurobiology of disease', 'Journal of biomedical materials research. Part A', 'PloS one', 'Chinese medical journal', 'Oncotarget', 'Aging clinical and experimental research', 'Nature reviews. Neurology', 'NeuroImage', 'Oxidative medicine and cellular longevity', 'Annals of neurology', 'Nature reviews. Molecular cell biology', 'Journal of neurochemistry', 'Critical reviews in eukaryotic gene expression', 'Acta histochemica', 'Neural plasticity', 'Neurology', 'Journal of ethnopharmacology', 'Expert opinion on drug discovery', 'Antioxidants & redox signaling', 'The Journal of neuroscience : the official journal of the Society for Neuroscience', 'Biochimica et biophysica acta', 'Le Journal medical libanais. The Lebanese medical journal', 'Biogerontology', 'Biochimica et biophysica acta', 'BMC research notes', 'Marine drugs', 'NeuroImage', 'JAMA neurology', 'CNS neuroscience & therapeutics', 'CNS neuroscience & therapeutics', 'Neurobiology of aging', 'Disease markers', 'Journal of neural transmission (Vienna, Austria : 1996)', 'Brain research bulletin', 'The British journal of nutrition', 'Genome biology', 'Phytomedicine : international journal of phytotherapy and phytopharmacology', 'Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism', 'JAMA neurology', 'Scientific reports', 'Nucleic acids research', 'Glia', 'Molecular and cellular endocrinology', 'Progress in retinal and eye research', 'Molecular medicine reports', 'European journal of pharmacology', 'NeuroImage', 'Analytical chemistry', 'Neurobiology of aging', 'Neuroscience', 'Scientific reports', 'PLoS genetics', 'Seminars in cell & developmental biology', 'The Lancet. Neurology', 'NeuroImage', 'PloS one', "Journal of Parkinson's disease", 'Biochimica et biophysica acta', 'JAMA neurology', 'Journal of orthopaedic research : official publication of the Orthopaedic Research Society', 'Scientific reports', 'Brain and language', 'Stem cells (Dayton, Ohio)', "Journal of Alzheimer's disease : JAD", "Journal of Alzheimer's disease : JAD", 'Acta neurologica Scandinavica', 'PloS one', 'Nature immunology', 'Neurobiology of aging', 'The Journal of neuroscience : the official journal of the Society for Neuroscience', 'Neurochemistry international', 'Aging cell', 'The journal of nutrition, health & aging', "Alzheimer's & dementia : the journal of the Alzheimer's Association", 'Proceedings of the National Academy of Sciences of the United States of America', 'The American journal of clinical nutrition', 'Trends in neurosciences', 'The Cochrane database of systematic reviews', 'PloS one', 'PloS one', 'Brain research', 'The European respiratory journal', 'CNS & neurological disorders drug targets', 'Neuron', 'NeuroImage. Clinical', 'Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie', 'Current opinion in psychiatry', 'Current pharmaceutical biotechnology', 'Redox biology', 'Alternative therapies in health and medicine', 'Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology', 'Neuroscience', 'Biochimica et biophysica acta', 'Neuro-degenerative diseases', 'The Journal of neuroscience : the official journal of the Society for Neuroscience', 'Annals of family medicine', 'Ageing research reviews', 'Nucleic acids research', 'The Journal of clinical investigation', 'Advances in gerontology = Uspekhi gerontologii', 'The journal of nutrition, health & aging', 'BMB reports', 'JAMA neurology', 'Neurobiology of aging', 'Frontiers in bioscience (Landmark edition)', 'Frontiers in bioscience (Landmark edition)', 'Antioxidants & redox signaling', 'Medicinal chemistry (Shariqah (United Arab Emirates))', 'Experimental gerontology', 'Neurologia (Barcelona, Spain)', 'Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics', 'Accident; analysis and prevention', 'Recent patents on drug delivery & formulation', 'Journal of neural transmission (Vienna, Austria : 1996)', 'Seminars in neurology', 'mBio', 'Current medicinal chemistry', 'Parkinsonism & related disorders', 'Drugs & aging', 'CNS drugs', 'Experimental neurology', 'The Lancet. Neurology', 'Neurobiology of disease', 'Autophagy', 'Cell cycle (Georgetown, Tex.)', 'Rejuvenation research', 'Methods (San Diego, Calif.)', 'Psychosomatic medicine', 'Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association', 'The Journal of neuroscience : the official journal of the Society for Neuroscience', 'Journal of neuropathology and experimental neurology', 'Molecules (Basel, Switzerland)', 'Molecular neurobiology', 'Ageing research reviews', 'Nutrients', 'Experimental gerontology', 'Neuroscience', 'Parkinsonism & related disorders', 'Journal of neurology', 'Biochemical and biophysical research communications', 'Neurobiology of disease', 'Nature reviews. Endocrinology', 'Bone', 'Neurobiology of aging', 'Cell metabolism', 'Journal of genetics and genomics = Yi chuan xue bao', 'Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine', 'European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society', 'PLoS computational biology', 'PloS one', 'BMC neurology', 'PloS one', 'Molecular psychiatry', 'Journal of the International Neuropsychological Society : JINS', 'The Journal of neuroscience : the official journal of the Society for Neuroscience', 'Aging clinical and experimental research', 'Molecular biology reports', 'JAMA neurology', 'CNS & neurological disorders drug targets', 'BMC bioinformatics', 'International journal of molecular sciences', 'PloS one', 'Nature medicine', 'Aging', 'Clinical drug investigation', 'NeuroImage', 'Neurobiology of disease', 'Archives of pharmacal research', 'International journal of rheumatic diseases', 'Experimental gerontology', "Journal of Alzheimer's disease : JAD", 'Immunologic research', 'European journal of clinical nutrition', 'Rheumatology international', 'Acta neuropathologica communications', 'Dysphagia', 'Neurobiology of aging', 'The Clinical neuropsychologist', 'Biochimica et biophysica acta', 'The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry', 'CNS & neurological disorders drug targets', 'Nutrients', 'Molecular genetics and metabolism', "Alzheimer's & dementia : the journal of the Alzheimer's Association", 'Acta neurologica Scandinavica', 'The Lancet. Neurology', 'Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS)', 'Cell transplantation', 'Acta neuropathologica communications', 'Molecular neurobiology', 'BioMed research international', 'Journal of neuroscience methods', 'PloS one', 'Parkinsonism & related disorders', 'Human molecular genetics', 'Current pharmaceutical biotechnology', 'Trends in neurosciences', 'Glia', "Journal of Alzheimer's disease : JAD", 'Cell death & disease', 'Current Alzheimer research', 'Current Alzheimer research', 'Journal of neural transmission (Vienna, Austria : 1996)', 'Experimental cell research', 'Journal of neural transmission (Vienna, Austria : 1996)', 'Journal of neurosurgery. Spine', 'Journal of neurology', 'Molecular systems biology', 'Aging cell', 'Cell death & disease', 'BioMed research international', 'Asian journal of psychiatry', 'Neuropathology and applied neurobiology', 'Antiviral therapy', 'The International journal of neuroscience', 'Neurobiology of aging', 'Journal of radiation research', 'BioMed research international', 'Neurochemistry international', 'Autophagy', 'Journal of neurosurgery. Spine', 'Neurology', 'Free radical research', 'Acta clinica Croatica', 'Journal of bioenergetics and biomembranes', 'Biochimica et biophysica acta', 'Journal of the Medical Association of Thailand = Chotmaihet thangphaet', 'Neuroinformatics', 'Advances in experimental medicine and biology', 'Brain : a journal of neurology', 'Research in sports medicine (Print)', 'Computers in biology and medicine', 'Current Alzheimer research', "Journal of Alzheimer's disease : JAD", 'Journal of neuropathology and experimental neurology', 'Journal of neuropathology and experimental neurology', 'Critical reviews in food science and nutrition', 'The Journal of clinical investigation', 'Recent patents on endocrine, metabolic & immune drug discovery', 'Current opinion in immunology', 'Environmental health perspectives', 'Human molecular genetics', 'JAMA psychiatry', 'Environmental health : a global access science source', 'Journal of neuroscience methods', 'Acta neurologica Belgica', 'Current opinion in HIV and AIDS', 'The American journal of clinical nutrition', 'Critical reviews in food science and nutrition', 'Monographs in oral science', 'Annals of neurology', 'The journals of gerontology. Series A, Biological sciences and medical sciences', 'Neurobiology of disease', 'Human molecular genetics', 'BioMed research international', 'BioMed research international', 'Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology', 'The Journal of neuroscience : the official journal of the Society for Neuroscience', 'Journal of molecular neuroscience : MN', 'Neurology', 'Journal of clinical immunology', 'Annals of medicine', 'Proceedings of the National Academy of Sciences of the United States of America', 'Nutrients', 'Chemical Society reviews', 'Sensors (Basel, Switzerland)', 'The European journal of neuroscience', 'Molecular neurobiology', 'Neuropathology and applied neurobiology', 'Current drug targets', 'AJNR. American journal of neuroradiology', 'Human molecular genetics', 'Angewandte Chemie (International ed. in English)', 'Ageing research reviews', 'Neurobiology of disease', 'PloS one', 'BMC medical research methodology', 'Neurology', 'Biochimica et biophysica acta', 'Physiological research', 'Neuroscience', 'Trends in neurosciences', 'Trends in neurosciences', 'Mayo Clinic proceedings', 'Oxidative medicine and cellular longevity', 'Neurology', 'Nature', 'Oxidative medicine and cellular longevity', 'The Annals of pharmacotherapy', 'Geriatrics & gerontology international', 'Acta clinica Belgica', 'Biological psychiatry', 'Aging cell', "Journal of Alzheimer's disease : JAD", "Journal of Parkinson's disease", 'Current pharmaceutical design', 'Critical reviews in food science and nutrition', 'Human brain mapping', 'Journal of psychiatric research', 'Ageing research reviews', 'Translational research : the journal of laboratory and clinical medicine', 'Neuroimmunomodulation', 'Cell cycle (Georgetown, Tex.)', "Alzheimer's & dementia : the journal of the Alzheimer's Association", "Alzheimer's & dementia : the journal of the Alzheimer's Association", 'Swiss medical weekly', 'Annals of neurology', 'PloS one', 'Proceedings of the National Academy of Sciences of the United States of America', 'JAMA neurology', 'Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology', 'PloS one', 'Redox biology', 'PloS one', 'Experimental gerontology', 'Current Alzheimer research', 'Antioxidants & redox signaling', 'PloS one', 'Diabetes/metabolism research and reviews', 'Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology', 'Studies in health technology and informatics', "Journal of Alzheimer's disease : JAD", 'Cell metabolism', 'Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine', 'Ageing research reviews', "Journal of Alzheimer's disease : JAD", 'Biochimica et biophysica acta', 'Current Alzheimer research', 'Ageing research reviews', 'Biochimica et biophysica acta', 'Frontiers in bioscience (Scholar edition)', 'Frontiers in bioscience (Landmark edition)', 'Physiological reviews', 'Clinical interventions in aging', 'Global health action', 'Ageing research reviews', 'Pain medicine (Malden, Mass.)', 'Neurology', 'PloS one', 'The Journal of biological chemistry', 'Pharmacology & therapeutics', 'Metabolism: clinical and experimental', 'Neurobiology of aging', 'Stroke', 'Aging cell', 'Progress in lipid research', 'Mechanisms of ageing and development', 'Mitochondrion', 'Parkinsonism & related disorders', 'Immunology', 'Translational stroke research', 'BMC medical genomics', 'Geriatrics & gerontology international', 'Cell stem cell', 'BMC public health', 'European journal of neurology', 'PloS one', 'Disease models & mechanisms', 'Human genetics', 'Neurology', 'European journal of nuclear medicine and molecular imaging', 'Journal of psychiatric research', 'Clinical anatomy (New York, N.Y.)', 'Cell research', 'Molecular and cellular biology', 'Missouri medicine', 'Mechanisms of ageing and development', 'Clinical anatomy (New York, N.Y.)', 'Molecular and cellular neurosciences', 'Neurobiology of aging', 'Pakistan journal of biological sciences : PJBS', 'Proteomics. Clinical applications', 'Acta neuropathologica communications', "Journal of Alzheimer's disease : JAD", 'Annals of neurology', 'International review of neurobiology', 'Advances in colloid and interface science', 'The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry', 'Rejuvenation research', 'Journal of geriatric psychiatry and neurology', 'Nursing New Zealand (Wellington, N.Z. : 1995)', 'International journal of biological macromolecules', 'Toxicology', 'Current opinion in neurology', 'Cell reports', 'International journal of molecular sciences', 'Cell death & disease', 'Human reproduction (Oxford, England)', 'PloS one', 'JAMA neurology', 'ASN neuro', 'Current drug metabolism', 'Tumori', 'Nucleus (Austin, Tex.)', 'PloS one', 'Hypertension (Dallas, Tex. : 1979)', 'Brain research', 'Neurobiology of aging', 'European journal of clinical investigation', 'Aging clinical and experimental research', 'Expert review of neurotherapeutics', 'Movement disorders : official journal of the Movement Disorder Society', 'JAMA psychiatry', 'Neurology', 'Revista clinica espanola', 'Neuropsychologia', 'Anti-cancer agents in medicinal chemistry', 'BMC public health', 'Reviews in endocrine & metabolic disorders', 'Journal of neuroinflammation', 'PloS one', 'Current pharmaceutical design', 'Brain imaging and behavior', 'Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS)', "Journal of Alzheimer's disease : JAD", 'PloS one', 'NeuroImage', 'Current topics in medicinal chemistry', 'PloS one', 'Supplements to Clinical neurophysiology', 'Supplements to Clinical neurophysiology', 'The Journal of neuroscience : the official journal of the Society for Neuroscience', 'Neurochemistry international', 'European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society', 'PloS one', 'Advances in nutrition (Bethesda, Md.)', 'Journal of neurochemistry', 'Acta virologica', 'Stem cells translational medicine', 'FASEB journal : official publication of the Federation of American Societies for Experimental Biology', 'Diabetes care', 'Mitochondrion', 'NeuroImage', 'Sleep', 'Neurobiology of aging', "Journal of Alzheimer's disease : JAD", 'Oxidative medicine and cellular longevity', 'Journal of proteome research', 'Oxidative medicine and cellular longevity', 'Journal of neurology, neurosurgery, and psychiatry', 'Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques', 'Biochimica et biophysica acta', 'Drug discovery today', 'PloS one', 'Zeitschrift fur Gerontologie und Geriatrie', 'The Journal of neuroscience : the official journal of the Society for Neuroscience', 'Biochimie', 'Current topics in medicinal chemistry', 'The International journal of neuroscience', "Alzheimer's & dementia : the journal of the Alzheimer's Association", 'Expert opinion on therapeutic targets', 'Aging', 'Annals of the New York Academy of Sciences', 'PloS one', 'PloS one', 'PloS one', 'Molecular cell', 'Epigenetics', 'Acta neuropathologica', 'Experimental eye research', 'The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry', 'Journal of neurology', 'Neuropsychology', 'Free radical biology & medicine', 'Neurobiology of disease', 'Biochemical Society transactions', 'Oxidative medicine and cellular longevity', 'Human brain mapping', 'International journal of molecular sciences', 'Neuropsychologia', 'Annals of the New York Academy of Sciences', 'Molecular and cellular neurosciences', 'Trends in cell biology', 'Analytical and bioanalytical chemistry', 'Drugs & aging', 'Neuroscience letters', 'Sub-cellular biochemistry', 'Neurosurgical focus', "Jornal brasileiro de nefrologia : 'orgao oficial de Sociedades Brasileira e Latino-Americana de Nefrologia", 'Journal of theoretical biology', 'International journal of molecular sciences', 'JAMA neurology', 'Autophagy', 'PloS one', 'Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology', 'Nucleic acids research', 'Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association', 'The Journal of surgical research', 'Journal of proteome research', 'Molecular neurobiology', 'Molecular imaging', 'Frontiers in bioscience (Landmark edition)', 'Cell', 'PloS one', 'BMC geriatrics', 'Free radical biology & medicine', 'DNA repair', 'CNS neuroscience & therapeutics', 'Brain connectivity', 'Free radical research', 'Gerontology', 'The journals of gerontology. Series A, Biological sciences and medical sciences', 'RNA biology', 'Age and ageing', 'Molecules and cells', 'Ageing research reviews', 'Trends in endocrinology and metabolism: TEM', 'Journal of visualized experiments : JoVE', 'Critical reviews in food science and nutrition', 'Current Alzheimer research', 'Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al]', 'Neurobiology of aging', 'Handbook of clinical neurology', 'Postepy higieny i medycyny doswiadczalnej (Online)', 'Nature reviews. Neurology', 'Journal of neurogenetics', 'Archives of gerontology and geriatrics', 'Dialogues in clinical neuroscience', 'Dialogues in clinical neuroscience', 'Brain : a journal of neurology', 'Current drug targets', 'JAMA neurology', "Journal of Alzheimer's disease : JAD", 'Experimental eye research', 'Free radical biology & medicine', 'Archives of osteoporosis', 'Brain imaging and behavior', 'Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics', 'Current drug targets', 'Cold Spring Harbor perspectives in biology', 'Brain, behavior, and immunity', 'The Journal of neuroscience : the official journal of the Society for Neuroscience', 'Biochimica et biophysica acta', 'Oncology reports', 'Cellular and molecular life sciences : CMLS', 'The journal of the Royal College of Physicians of Edinburgh', 'Proteins', 'Brain research', 'Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation', 'FEMS yeast research', 'Proceedings of the National Academy of Sciences of the United States of America', 'Neuroscience letters', 'Journal of orthopaedic research : official publication of the Orthopaedic Research Society', 'DNA repair', "Alzheimer's & dementia : the journal of the Alzheimer's Association", 'Experimental gerontology', 'PloS one', 'The Journal of clinical investigation', 'Current pharmaceutical design', 'Biomolecular concepts', 'Movement disorders : official journal of the Movement Disorder Society', 'Current pharmaceutical design', 'Current pharmaceutical design', 'Cell stress & chaperones', 'Trends in genetics : TIG', 'Aging cell', 'ACS chemical neuroscience', 'Neuro-degenerative diseases', "Journal of Alzheimer's disease : JAD", 'Biochimica et biophysica acta', 'Journal of sleep research', 'Cell stem cell', 'Steroids', 'Critical care (London, England)', 'Neuroscience', 'Free radical biology & medicine', 'Mechanisms of ageing and development', 'Molecular neurodegeneration', 'Circulation research', 'Nature', 'Aging cell', 'Archives of pharmacal research', 'Neuron', 'PloS one', 'Journal of neurovirology', 'Molecular neurobiology', 'Mutation research', 'Pharmaceutical biology', 'PloS one', 'Postgraduate medicine', 'Acta medica Indonesiana', 'Clinical chemistry and laboratory medicine', 'Handbook of clinical neurology', 'PloS one', 'PLoS genetics', 'Annals of neurology', 'Frontiers in bioscience (Landmark edition)', 'Current medicinal chemistry', 'Discovery medicine', "Journal of Alzheimer's disease : JAD", "Journal of Alzheimer's disease : JAD", 'Pharmacology, biochemistry, and behavior', 'International immunopharmacology', 'Antioxidants & redox signaling', 'Experimental gerontology', 'Behavioural neurology', 'Autophagy', 'Brain connectivity', 'Movement disorders : official journal of the Movement Disorder Society', 'Schizophrenia research', 'Cerebral cortex (New York, N.Y. : 1991)', 'PloS one', 'Apoptosis : an international journal on programmed cell death', 'Sub-cellular biochemistry', 'Rejuvenation research', 'Mediators of inflammation', 'Mini reviews in medicinal chemistry', 'Drugs & aging', 'Clinical chemistry and laboratory medicine', 'Neurobiology of aging', 'BMC family practice', 'Brazilian journal of physical therapy', 'The Journal of heart valve disease', 'Journal of cellular biochemistry', 'Nature reviews. Genetics', 'The Journal of neuroscience : the official journal of the Society for Neuroscience', 'The European respiratory journal', 'Archives of medical research', 'Jornal da Sociedade Brasileira de Fonoaudiologia', 'Experimental gerontology', 'Oxidative medicine and cellular longevity', 'Cell reports', 'Prion', 'Journal of endocrinological investigation', 'Aging cell', 'The Journal of biological chemistry', 'Human molecular genetics', 'Biomarkers in medicine', 'PloS one', 'Journal of visualized experiments : JoVE', 'Circulation research', 'Neuromolecular medicine', 'Molecular neurobiology', 'Nestle Nutrition Institute workshop series', 'Journal of proteome research', 'Proceedings of the National Academy of Sciences of the United States of America', 'Annual review of physiology', 'Combinatorial chemistry & high throughput screening', 'PloS one', 'Seminars in nuclear medicine', 'Current pharmaceutical design', 'Molecules (Basel, Switzerland)', 'Mutation research', 'NeuroImage', 'Antioxidants & redox signaling', 'Neurochemistry international', 'Ageing research reviews', 'Cell cycle (Georgetown, Tex.)', 'Cell death and differentiation', 'Current biology : CB', 'Current medicinal chemistry', 'Aging clinical and experimental research', 'Organogenesis', 'Biochimica et biophysica acta', "Journal of Alzheimer's disease : JAD", 'Chemical Society reviews', 'Molecules (Basel, Switzerland)', 'Molecular neurobiology', 'Journal of the neurological sciences', 'Oxidative medicine and cellular longevity', 'Future medicinal chemistry', 'Neuroscience letters', 'Current pharmaceutical design', 'Biochimica et biophysica acta', 'Apoptosis : an international journal on programmed cell death', 'Experimental gerontology', "Journal of Alzheimer's disease : JAD", 'Age (Dordrecht, Netherlands)', 'Biochimica et biophysica acta', 'Molecular neurobiology', 'Neurotoxicity research', 'Nutrition research reviews', 'Giornale italiano di medicina del lavoro ed ergonomia', 'Neurobiology of aging', 'Brain, behavior, and immunity', 'Chinese medical journal', 'Journal of radiation research', 'PloS one', 'PloS one', 'Neuropharmacology', 'Advances in pharmacology (San Diego, Calif.)', 'Neurochemistry international', 'Seminars in nephrology', 'Translational psychiatry', 'European journal of anaesthesiology', 'Biochimie', 'Clinical science (London, England : 1979)', 'Annals of the New York Academy of Sciences', 'Chemico-biological interactions', 'Neurochemistry international', 'Clinical interventions in aging', 'International psychogeriatrics', 'Acta neuropathologica', 'Neuron', 'Current opinion in pediatrics', 'Nuclear medicine communications', 'Ageing research reviews', 'Neuropathology and applied neurobiology', 'Current pharmaceutical design', 'Archives of gerontology and geriatrics', 'Progress in molecular biology and translational science', 'Molecular neurodegeneration', 'Journal of ethnopharmacology', 'NMR in biomedicine', 'BioFactors (Oxford, England)', 'Acta neuropathologica', 'Progress in neuro-psychopharmacology & biological psychiatry', 'Prostaglandins, leukotrienes, and essential fatty acids', 'The international journal of biochemistry & cell biology', "Journal of Alzheimer's disease : JAD", 'Molecular neurobiology', 'Experimental gerontology', "Journal of Alzheimer's disease : JAD", 'Journal of neurochemistry', 'Neurotoxicity research', 'Oxidative medicine and cellular longevity', 'PloS one', 'Nucleic acids research', 'Journal of neural transmission (Vienna, Austria : 1996)', 'Biochemical pharmacology', 'Lab on a chip', 'Free radical biology & medicine', 'Hormones and behavior', 'Nutritional neuroscience', 'Nutritional neuroscience', 'Journal of biosciences', 'American journal of physiology. Regulatory, integrative and comparative physiology', 'Schizophrenia research', 'Seminars in dialysis', 'Journal of mental health (Abingdon, England)', 'Circulation research', 'Toxicological sciences : an official journal of the Society of Toxicology', 'Aging & mental health', "Journal of Alzheimer's disease : JAD", 'Journal of neurovirology', 'American journal of medical genetics. Part A', 'Endocrine, metabolic & immune disorders drug targets', 'Cell', 'Biochimica et biophysica acta', 'Pain medicine (Malden, Mass.)', 'The journals of gerontology. Series A, Biological sciences and medical sciences', 'Journal of the neurological sciences', 'Progress in molecular biology and translational science', 'Age (Dordrecht, Netherlands)', 'EMBO molecular medicine', 'Oncology reports', 'Critical reviews in clinical laboratory sciences', 'Journal of neurological surgery. Part A, Central European neurosurgery', 'Neurochemical research', 'Prion', 'Current medicinal chemistry', 'Current medicinal chemistry', 'Journal of medicinal food', 'Age and ageing', 'The international journal of biochemistry & cell biology', 'Age and ageing', 'BioFactors (Oxford, England)', 'Neurochemistry international', 'Human reproduction (Oxford, England)', 'Menopause (New York, N.Y.)', 'PloS one', 'Neuroscience letters', 'Medical hypotheses', 'Advances in experimental medicine and biology', 'Platelets', 'PloS one', 'Journal of the neurological sciences', 'Disease markers', 'Journal of physiology and biochemistry', 'Journal of the Formosan Medical Association = Taiwan yi zhi', 'Cornea', 'Journal of neurogenetics', 'Pharmacological reports : PR', 'Cancer letters', 'Current topics in medicinal chemistry', 'Nature', 'Archives of neurology', 'Neurobiology of aging', 'DNA and cell biology', 'Journal of inherited metabolic disease', 'Neuro-degenerative diseases', 'Neuro-degenerative diseases', 'JPEN. Journal of parenteral and enteral nutrition', 'Indian journal of public health', 'International journal of stroke : official journal of the International Stroke Society', 'Current pharmaceutical design', 'Current pharmaceutical design', 'Neurobiology of disease', 'Seminars in cell & developmental biology', 'IEEE ... International Conference on Rehabilitation Robotics : [proceedings]', 'Tissue engineering. Part B, Reviews', 'International journal of molecular sciences', 'Neurobiology of disease', 'Journal of agricultural and food chemistry', 'Journal of spinal disorders & techniques', 'Current topics in behavioral neurosciences', 'The Journal of bone and joint surgery. American volume', 'Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference', 'Nutrients', 'Reviews in neurological diseases', 'Cytoskeleton (Hoboken, N.J.)', 'The Journal of biological chemistry', 'Disease models & mechanisms', 'Journal of neuroscience methods', 'Genetic testing and molecular biomarkers', 'Age (Dordrecht, Netherlands)', 'PloS one', 'Current pharmaceutical design', "American journal of Alzheimer's disease and other dementias", 'Frontiers in bioscience (Scholar edition)', 'Frontiers in bioscience (Elite edition)', 'Current pharmaceutical biotechnology', 'Oxidative medicine and cellular longevity', 'Autophagy', 'Autophagy', 'Acta neuropathologica', 'The American journal of hospice & palliative care', 'PloS one', 'The American journal of pathology', 'Brain : a journal of neurology', 'Biochimica et biophysica acta', 'Journal of neuroscience methods', 'Biochimica et biophysica acta', 'Biochemical Society transactions', 'Maturitas', 'Neurobiology of disease', 'Epilepsia', 'The Journal of neuroscience : the official journal of the Society for Neuroscience', 'Pharmacological reviews', 'Journal of bioenergetics and biomembranes', 'Bioorganic & medicinal chemistry', 'Archives of toxicology', "Alzheimer's & dementia : the journal of the Alzheimer's Association", 'The neurologist', 'Metallomics : integrated biometal science', 'British journal of pharmacology', 'Chang Gung medical journal', 'Free radical research', 'Nature', 'PloS one', 'Neurogenetics', 'Cellular and molecular life sciences : CMLS', 'Comprehensive Physiology', 'Biochimica et biophysica acta', 'The Journal of pathology', 'Biochimica et biophysica acta', 'Neurochemical research', "Journal of Alzheimer's disease : JAD", 'Aging clinical and experimental research', 'Aging cell', 'Stem cells (Dayton, Ohio)', 'Journal of neuroscience research', 'PLoS genetics', 'Biochimica et biophysica acta', 'The Journal of clinical investigation', 'Journal of vascular surgery', 'Toxicological sciences : an official journal of the Society of Toxicology', 'Methods in molecular biology (Clifton, N.J.)', 'Recent patents on cardiovascular drug discovery', "Journal of Alzheimer's disease : JAD", 'Journal of neurochemistry', 'Journal of the neurological sciences', 'Acta chirurgica Iugoslavica', 'Mayo Clinic proceedings', 'The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians', 'The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry', 'Epilepsy research', 'Biochimica et biophysica acta', 'Parkinsonism & related disorders', 'BMC medicine', 'Expert review of neurotherapeutics', 'Neurobiology of aging', 'Progress in neurobiology', 'Rejuvenation research', 'Genome research', 'Folia neuropathologica', 'Brain, behavior, and immunity', 'Molecular aspects of medicine', 'Canadian journal of psychiatry. Revue canadienne de psychiatrie', 'Neuromolecular medicine', 'Current opinion in structural biology', 'PloS one', 'Nucleus (Austin, Tex.)', 'Free radical research', 'Methods in molecular biology (Clifton, N.J.)', 'Biochimica et biophysica acta', 'NeuroImage', 'European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society', 'Annals of the New York Academy of Sciences', 'Human molecular genetics', 'Biochemical Society transactions', 'Biochemical Society transactions', 'Biochimica et biophysica acta', 'Neurology', 'Seminars in cutaneous medicine and surgery', 'Respiratory physiology & neurobiology', 'Biogerontology', 'Acta neurochirurgica. Supplement', 'Current pharmaceutical design', 'Mechanisms of ageing and development', 'Critical reviews in clinical laboratory sciences', 'PloS one', 'CNS drugs', 'Journal of magnetic resonance imaging : JMRI', 'Glia', 'International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience', 'Medical hypotheses', 'Expert reviews in molecular medicine', 'Expert review of proteomics', 'Archives of gerontology and geriatrics', 'RNA biology', "Journal of Alzheimer's disease : JAD", 'Current topics in behavioral neurosciences', 'CNS & neurological disorders drug targets', 'CNS & neurological disorders drug targets', 'European neurology', 'Neuroscience letters', 'Movement disorders : official journal of the Movement Disorder Society', 'BMB reports', 'Current Alzheimer research', 'Acta neuropathologica', 'Mechanisms of ageing and development', 'Molecular & cellular proteomics : MCP', 'Neurobiology of aging', 'German medical science : GMS e-journal', 'BMC physiology', 'Neurobiology of aging', 'Current topics in medicinal chemistry', 'Neurobiology of aging', 'Brain : a journal of neurology', 'Stem cells (Dayton, Ohio)', 'Bioorganic & medicinal chemistry letters', 'Acta neurologica Scandinavica', 'The Journal of biological chemistry', 'West African journal of medicine', 'Pharmacology, biochemistry, and behavior', 'Archives of gerontology and geriatrics', 'Current drug targets', 'Journal of neuroinflammation', "Annali dell'Istituto superiore di sanita", 'Cognition & emotion', 'Recent patents on food, nutrition & agriculture', "Journal of Alzheimer's disease : JAD", 'Mutation research', 'Aging', 'Analytical chemistry', 'Neuroscience letters', 'Current osteoporosis reports', 'Neuroscience', 'Cell death and differentiation', 'Presse medicale (Paris, France : 1983)', 'Amino acids', 'Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology', 'Expert review of neurotherapeutics', 'Experimental biology and medicine (Maywood, N.J.)', 'Journal of the neurological sciences', 'Experimental gerontology', 'Molecular biology of the cell', 'Stem cell research & therapy', 'Inflammation', "Journal of Alzheimer's disease : JAD", 'Human molecular genetics', 'Sleep medicine', 'The Lancet. Neurology', 'The international journal of cardiovascular imaging', 'Alzheimer disease and associated disorders', 'Neurology', 'Clinical chemistry and laboratory medicine', 'Neurochemical research', "Journal of Alzheimer's disease : JAD", 'Methods in enzymology', 'Acta neurologica Belgica', 'Lancet (London, England)', 'Journal of neural transmission (Vienna, Austria : 1996)', 'Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics', 'Nature reviews. Cardiology', 'PloS one', 'The international journal of biochemistry & cell biology', 'Autophagy', 'The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry', 'PloS one', 'International journal of immunopathology and pharmacology', 'Neurobiology of aging', 'Molecular neurobiology', 'Biochemical and biophysical research communications', 'Translational psychiatry', 'Current aging science', 'Antioxidants & redox signaling', 'Current pharmaceutical design', 'The British journal of ophthalmology', 'NeuroImage', 'Mutagenesis', 'Mutagenesis', 'Spine', "Journal of Alzheimer's disease : JAD", 'Nuclear medicine review. Central & Eastern Europe', 'Behavioural brain research', 'Clinica chimica acta; international journal of clinical chemistry', 'Progress in neurobiology', 'The journal of nutrition, health & aging', 'Antioxidants & redox signaling', 'Philosophical transactions of the Royal Society of London. Series B, Biological sciences', 'Philosophical transactions of the Royal Society of London. Series B, Biological sciences', 'Acta neurochirurgica. Supplement', 'PloS one', 'International journal of pharmaceutics', 'The journal of nutrition, health & aging', 'Neurochemical research', 'Free radical biology & medicine', 'Acta neuropathologica', 'Metallomics : integrated biometal science', 'The journal of spinal cord medicine', 'CNS neuroscience & therapeutics', 'Journal of geriatric psychiatry and neurology', 'Journal of neurochemistry', 'Gerontology', 'Molecules (Basel, Switzerland)', 'Neuropsychologia', 'Neuropathology and applied neurobiology', 'Biochimica et biophysica acta', "Journal of Alzheimer's disease : JAD", "Journal of Alzheimer's disease : JAD", 'PloS one', 'Arquivos brasileiros de cardiologia', 'The Journal of biological chemistry', 'Stroke', 'Discovery medicine', 'Journal of neuro-oncology', 'PloS one', 'Biogerontology', 'Handbook of experimental pharmacology', 'Brain : a journal of neurology', 'Experimental gerontology', 'Antioxidants & redox signaling', "Journal of Alzheimer's disease : JAD", 'European heart journal', 'Journal of the neurological sciences', 'BMC systems biology', 'Current drug targets', 'Current drug targets', 'Current drug targets', 'Current drug targets', 'Life sciences', 'Free radical research', 'Experimental gerontology', 'Journal of psychiatric research', 'Brain : a journal of neurology', 'Journal of environmental monitoring : JEM', 'Clinics in orthopedic surgery', 'Medical hypotheses', 'The Lancet. Neurology', 'Experimental gerontology', 'Current aging science', 'Current aging science', 'Ageing research reviews', 'Trends in biochemical sciences', 'The Lancet. Neurology', 'Cell', 'Experimental gerontology', 'Chemical Society reviews', 'Nature reviews. Neurology', 'Antioxidants & redox signaling', 'PLoS biology', 'Neurobiology of aging', 'BMC cancer', 'The review of diabetic studies : RDS', 'International psychogeriatrics', 'Methods in molecular biology (Clifton, N.J.)', 'Methods in molecular biology (Clifton, N.J.)', 'Current pharmaceutical design', 'Vision research', 'Advances in experimental medicine and biology', 'The Journal of neuroscience : the official journal of the Society for Neuroscience', 'Current medicinal chemistry', 'Trials', 'Rejuvenation research', 'Proceedings of the National Academy of Sciences of the United States of America', 'Brain : a journal of neurology', 'Recent patents on food, nutrition & agriculture', 'Annals of the New York Academy of Sciences', 'Antioxidants & redox signaling', 'Current topics in medicinal chemistry', 'Age (Dordrecht, Netherlands)', 'Acta neurochirurgica', 'DNA repair', 'PloS one', 'Neurochemistry international', 'Neurology', 'Biochimica et biophysica acta', 'Science China. Life sciences', 'Neurobiology of aging', 'Neurologia medico-chirurgica', 'Expert review of neurotherapeutics', 'Progress in lipid research', 'Behavioural brain research', 'Aging cell', 'European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society', 'TheScientificWorldJournal', "Journal of Alzheimer's disease : JAD", 'The Journal of neuroscience : the official journal of the Society for Neuroscience', 'Expert review of proteomics', 'Central nervous system agents in medicinal chemistry', 'CNS & neurological disorders drug targets', 'Neurobiology of disease', 'Physical medicine and rehabilitation clinics of North America', 'Molecular biology reports', 'American journal of therapeutics', 'Molecular neurobiology', 'Current Alzheimer research', 'Biochimica et biophysica acta', 'Biochimica et biophysica acta', 'Neurobiology of aging', 'Journal of inherited metabolic disease', 'Current medicinal chemistry', 'Molecular neurobiology', 'Progress in neurobiology', "Journal of Alzheimer's disease : JAD", "Journal of Alzheimer's disease : JAD", "Journal of Alzheimer's disease : JAD", 'Neuro-Signals', 'Journal of neural transmission (Vienna, Austria : 1996)', 'Expert reviews in molecular medicine', 'Science (New York, N.Y.)', 'Clinica chimica acta; international journal of clinical chemistry', 'Biochimica et biophysica acta', 'Current pharmaceutical design', 'Anatomical science international', 'Neurobiology of aging', 'British journal of biomedical science', 'Rejuvenation research', 'Expert opinion on investigational drugs', 'Genes, brain, and behavior', 'Rejuvenation research', 'Molecules (Basel, Switzerland)', 'Apoptosis : an international journal on programmed cell death', 'Acta neuropathologica', 'Current aging science', 'The American journal of managed care', 'Methods in molecular biology (Clifton, N.J.)', 'FASEB journal : official publication of the Federation of American Societies for Experimental Biology', 'PLoS genetics', 'Mechanisms of ageing and development', 'Science signaling', 'Neurochemical research', 'Current Alzheimer research', 'CNS & neurological disorders drug targets', 'International journal of molecular medicine', 'Neuro-degenerative diseases', 'The journal of nutrition, health & aging', 'Ageing research reviews', 'Journal of preventive medicine and public health = Yebang Uihakhoe chi', 'FASEB journal : official publication of the Federation of American Societies for Experimental Biology', 'The Journal of nutrition', 'The journals of gerontology. Series B, Psychological sciences and social sciences', 'Experimental gerontology', "Journal of Alzheimer's disease : JAD", "Journal of Alzheimer's disease : JAD", "Journal of Alzheimer's disease : JAD", 'Protein science : a publication of the Protein Society', 'NeuroImage', 'Pharmacology & therapeutics', 'NeuroImage', 'Journal of gastroenterology', 'The Israel Medical Association journal : IMAJ', 'Neurobiology of aging', "Journal of Alzheimer's disease : JAD", 'PloS one', 'Annual review of pathology', "Journal of Alzheimer's disease : JAD", "Journal of Alzheimer's disease : JAD", 'NeuroImage', 'Age and ageing', 'Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology', 'Current opinion in cell biology', 'Current pharmaceutical design', 'Acta neuropathologica', 'Frontiers in bioscience (Scholar edition)', 'Parkinsonism & related disorders', 'Current aging science', 'Central nervous system agents in medicinal chemistry', 'Journal of agricultural and food chemistry', 'Methods in molecular biology (Clifton, N.J.)', 'Philosophical transactions of the Royal Society of London. Series B, Biological sciences', 'Dementia and geriatric cognitive disorders', 'BMC genomics', 'Ageing research reviews', 'Chemical research in toxicology', 'Nucleic acids research', 'Proceedings of the National Academy of Sciences of the United States of America', 'Asia Pacific journal of clinical nutrition', 'Journal of neurosurgery', 'Investigacion clinica', 'Mechanisms of ageing and development', 'Expert review of neurotherapeutics', 'Medical hypotheses', 'Neurobiology of aging', 'Aging clinical and experimental research', 'Age (Dordrecht, Netherlands)', 'Medical hypotheses', 'Drugs of today (Barcelona, Spain : 1998)', 'Pharmacopsychiatry', 'Biochemistry. Biokhimiia', 'Expert review of neurotherapeutics', 'Anesthesia and analgesia', 'Experimental neurology', 'Journal of the Medical Association of Thailand = Chotmaihet thangphaet', 'Handbook of clinical neurology', 'Journal of biomechanics', 'The Journal of clinical endocrinology and metabolism', 'Advances in cancer research', 'PLoS genetics', 'The Practitioner', 'Cellular signalling', 'Journal of geriatric physical therapy (2001)', 'Trends in cell biology', 'Drugs & aging', 'Behavioural neurology', 'Biogerontology', 'Archives of gerontology and geriatrics', 'Trends in cell biology', 'The Journal of neuroscience : the official journal of the Society for Neuroscience', 'Journal of neural transmission (Vienna, Austria : 1996)', 'Archives of neurology', 'Journal of epidemiology', 'Journal of neurology', 'Digestive diseases (Basel, Switzerland)', 'Experimental neurology', 'Neuropathology : official journal of the Japanese Society of Neuropathology', 'Clinical and translational science', 'Neurobiology of aging', 'Expert opinion on emerging drugs', 'Cellular and molecular life sciences : CMLS', 'Clinical pharmacology and therapeutics', 'Current Alzheimer research', 'Environmental research', 'Gerontology', 'International journal of geriatric psychiatry', 'Maturitas', 'PloS one', 'Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001)', 'Infectious disorders drug targets', 'Biochimica et biophysica acta', 'International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience', 'Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology', 'The Journal of neuroscience : the official journal of the Society for Neuroscience', 'Current neurology and neuroscience reports', "Journal of Alzheimer's disease : JAD", 'Progress in brain research', 'Genes & development', 'The Journal of biological chemistry', 'Biochimica et biophysica acta', 'Neurobiology of aging', 'Cell cycle (Georgetown, Tex.)', 'Experimental gerontology', 'Developmental cell', 'Journal of neuropathology and experimental neurology', 'Sleep medicine', 'Journal of investigative medicine : the official publication of the American Federation for Clinical Research', 'Stem cells and development', 'Journal of neurosurgery. Spine', 'European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society', 'Progress in retinal and eye research', 'Acta neuropathologica', 'Critical reviews in clinical laboratory sciences', 'Proceedings of the National Academy of Sciences of the United States of America', 'The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry', 'Stem cells (Dayton, Ohio)', 'Current protein & peptide science', 'Current protein & peptide science', 'Prostaglandins, leukotrienes, and essential fatty acids', 'Current Alzheimer research', 'Current Alzheimer research', 'Acta neuropathologica', 'Molecular and cellular biology', 'Clinical interventions in aging', 'Chemico-biological interactions', 'Developments in ophthalmology', 'Prostaglandins, leukotrienes, and essential fatty acids', 'Journal of leukocyte biology', 'International journal of clinical pharmacology and therapeutics', 'Neurology', 'NeuroImage', 'Osteoarthritis and cartilage', 'Journal of the American Geriatrics Society', 'Journal of neurochemistry', 'BioFactors (Oxford, England)', 'Human brain mapping', 'Nature protocols', 'PloS one', 'Neuroscience letters', 'Brain research bulletin', 'Stem cells (Dayton, Ohio)', 'Proceedings of the National Academy of Sciences of the United States of America', 'Obesity reviews : an official journal of the International Association for the Study of Obesity', 'Biochimica et biophysica acta', 'Functional neurology', 'Neurobiology of aging', "Journal of Alzheimer's disease : JAD", 'Biological psychiatry', 'Cell adhesion & migration', 'Cell cycle (Georgetown, Tex.)', 'European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery', 'Journal of neural transmission (Vienna, Austria : 1996)', "Journal of Alzheimer's disease : JAD", 'Trends in neurosciences', 'FASEB journal : official publication of the Federation of American Societies for Experimental Biology', 'Proceedings of the National Academy of Sciences of the United States of America', 'Acta neuropathologica', 'Clinical science (London, England : 1979)', 'Journal of genetics and genomics = Yi chuan xue bao', 'Frontiers in bioscience (Landmark edition)', 'Acta neuropathologica', 'Nature nanotechnology', 'Microscopy research and technique', 'Brain, behavior, and immunity', 'The American journal of sports medicine', 'The Proceedings of the Nutrition Society', 'Aging cell', 'The journals of gerontology. Series A, Biological sciences and medical sciences', 'International journal of geriatric psychiatry', 'Methods in enzymology', "American journal of Alzheimer's disease and other dementias", 'Journal of internal medicine', 'Current psychiatry reports', 'Advances in experimental medicine and biology', 'Advances in experimental medicine and biology', 'The Journal of biological chemistry', 'BMC cell biology', 'The Journal of steroid biochemistry and molecular biology', 'Biological chemistry', 'European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery', 'Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention', 'Current protocols in toxicology', 'Cancer prevention research (Philadelphia, Pa.)', 'Cell', 'Brain pathology (Zurich, Switzerland)', 'Trends in cell biology', 'Genome', 'Methods in molecular biology (Clifton, N.J.)', 'Annals of the New York Academy of Sciences', 'Current topics in medicinal chemistry', 'Annals of the New York Academy of Sciences', 'Current pharmaceutical design', 'Journal of visualized experiments : JoVE', 'Current opinion in clinical nutrition and metabolic care', 'Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology', 'Medical science monitor : international medical journal of experimental and clinical research', 'Experimental gerontology', 'The Journal of pathology', 'Seminars in oncology', 'The Journal of nutrition', 'Journal of neuropathology and experimental neurology', 'Brain and cognition', 'Proceedings of the National Academy of Sciences of the United States of America', 'Autophagy', 'Cell cycle (Georgetown, Tex.)', 'Gerontology', 'Brain research', 'Aging cell', 'Acta neuropathologica', 'Journal of neuropathology and experimental neurology', 'Mutation research', "Journal of Alzheimer's disease : JAD", 'Mutation research', 'The Journal of biological chemistry', 'Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology', 'BioTechniques', 'Cell biochemistry and function', 'History of psychiatry', 'PloS one', 'Current opinion in clinical nutrition and metabolic care', 'Annals of neurology', 'Cellular and molecular life sciences : CMLS', 'Inflammopharmacology', 'Lab on a chip', 'Toxicology letters', 'Analytica chimica acta', 'Journal of clinical nursing', 'Neuroepidemiology', 'Expert opinion on pharmacotherapy', 'Nature reviews. Neuroscience', 'PloS one', 'Human molecular genetics', 'Free radical biology & medicine', 'Neuroscience letters', 'Journal of molecular neuroscience : MN', 'Autophagy', 'PloS one', 'Psychopharmacology', 'Movement disorders : official journal of the Movement Disorder Society', 'Neuroscience', 'NeuroImage', 'Neuroscience letters', 'Biochimica et biophysica acta', 'Current aging science', 'Indian journal of experimental biology', 'Neurochemical research', 'Journal of neurochemistry', 'Human brain mapping', 'CNS & neurological disorders drug targets', 'The European journal of neuroscience', 'Brazilian journal of otorhinolaryngology', 'Brain pathology (Zurich, Switzerland)', "Alzheimer's & dementia : the journal of the Alzheimer's Association", 'Journal of neurochemistry', 'Experimental gerontology', 'Journal of neurology', 'Chemico-biological interactions', 'Journal of Korean medical science', 'Biochimica et biophysica acta', 'Development (Cambridge, England)', 'The Southeast Asian journal of tropical medicine and public health', 'PloS one', "Journal of Alzheimer's disease : JAD", 'Expert opinion on therapeutic targets', 'East African medical journal', 'Endocrine, metabolic & immune disorders drug targets', 'The American journal of pathology', 'Neurobiology of aging', 'Neurobiology of aging', 'Frontiers in bioscience : a journal and virtual library', 'Medical hypotheses', 'International journal of nanomedicine', 'Experimental cell research', 'Infectious disorders drug targets', 'Cortex; a journal devoted to the study of the nervous system and behavior', 'Current neurovascular research', 'DNA repair', 'The Journal of biological chemistry', 'Proceedings of the National Academy of Sciences of the United States of America', 'Genetics', 'BJU international', 'The Journal of investigative dermatology', 'American journal of physical anthropology', 'Zentralblatt fur Neurochirurgie', 'Glia', 'Autophagy', 'Brain pathology (Zurich, Switzerland)', 'Methods in molecular biology (Clifton, N.J.)', 'Aging cell', 'Behavioural neurology', 'Trends in molecular medicine', 'Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie', 'Molecular immunology', 'Human molecular genetics', 'Current Alzheimer research', 'Neuroscience letters', 'Neurotoxicology', 'Studies in health technology and informatics', 'Biochimica et biophysica acta', 'Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society', 'Rejuvenation research', 'Methods in molecular biology (Clifton, N.J.)', 'Hormones (Athens, Greece)', 'Experimental gerontology', 'Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery', 'Trends in biochemical sciences', 'Clinical biomechanics (Bristol, Avon)', 'Current aging science', 'Mechanisms of ageing and development', 'Current pharmaceutical design', 'Rejuvenation research', 'Neuro-degenerative diseases', 'Nature', 'DNA repair', 'Current Alzheimer research', 'Neuromolecular medicine', 'Current opinion in chemical biology', 'The FEBS journal', 'Cellular and molecular life sciences : CMLS', 'Psychotherapy and psychosomatics', 'Suicide & life-threatening behavior', 'Cellular and molecular neurobiology', 'Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society', 'Mechanisms of ageing and development', 'Mechanisms of ageing and development', 'Journal of human genetics', 'Brain pathology (Zurich, Switzerland)', 'Hormones and behavior', 'Genes, brain, and behavior', 'CNS & neurological disorders drug targets', 'Cardiovascular & hematological disorders drug targets', 'Methods in molecular biology (Clifton, N.J.)', 'The EMBO journal', 'Acta pharmacologica Sinica', "Annali dell'Istituto superiore di sanita", 'Biological chemistry', 'Antioxidants & redox signaling', 'Sub-cellular biochemistry', 'Cell', 'NeuroImage', 'Proceedings of the National Academy of Sciences of the United States of America', 'NeuroImage', 'Handbook of experimental pharmacology', 'Journal of molecular neuroscience : MN', 'Movement disorders : official journal of the Movement Disorder Society', 'Journal of cellular and molecular medicine', 'Journal of pineal research', 'Novartis Foundation symposium', 'Novartis Foundation symposium', 'Health economics', 'CNS drugs', 'Clinical chemistry and laboratory medicine', 'Prostaglandins, leukotrienes, and essential fatty acids', 'Neurology', 'Annals of the New York Academy of Sciences', 'Expert review of neurotherapeutics', 'Clinical interventions in aging', 'Clinical interventions in aging', 'Journal of the Medical Association of Thailand = Chotmaihet thangphaet', 'The spine journal : official journal of the North American Spine Society', 'Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA', 'Human mutation', 'Journal of pain & palliative care pharmacotherapy', 'Journal of geriatric psychiatry and neurology', 'Frontiers in bioscience : a journal and virtual library', 'Frontiers in bioscience : a journal and virtual library', 'Acta neuropathologica', "American journal of Alzheimer's disease and other dementias", 'Progress in neuro-psychopharmacology & biological psychiatry', 'Antioxidants & redox signaling', 'Neurochemical research', 'Molecular cell', 'EMBO reports', 'Alaska medicine', 'The Biochemical journal', 'Current opinion in psychiatry', "Journal of Alzheimer's disease : JAD", 'Current Alzheimer research', 'The American journal of medicine', 'Medical science monitor : international medical journal of experimental and clinical research', 'Current pharmaceutical design', 'Epileptic disorders : international epilepsy journal with videotape', 'Neurochemistry international', 'The Lancet. Neurology', 'PloS one', 'Antioxidants & redox signaling', 'Advanced drug delivery reviews', 'International journal of mental health nursing', 'European journal of clinical nutrition', 'Annals of the New York Academy of Sciences', 'Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society', 'Cellular and molecular neurobiology', 'Journal of neural transmission (Vienna, Austria : 1996)', 'Antioxidants & redox signaling', 'Mechanisms of ageing and development', 'Experimental gerontology', 'BMC musculoskeletal disorders', 'Brain : a journal of neurology', 'Journal of neurochemistry', 'Journal of the neurological sciences', 'American journal of therapeutics', 'Antioxidants & redox signaling', 'Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases', 'Molecular & cellular proteomics : MCP', 'The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry', 'Free radical biology & medicine', 'Acta neuropathologica', 'Drug news & perspectives', 'Journal of neurochemistry', 'Regenerative medicine', 'Trends in cognitive sciences', 'Journal of neuroscience research', 'The FEBS journal', 'Sub-cellular biochemistry', 'Genetics', 'Folia neuropathologica', 'Surgical neurology', 'The EMBO journal', 'American journal of human genetics', 'Medical hypotheses', 'Seminars in cancer biology', 'Brain research', 'Movement disorders : official journal of the Movement Disorder Society', 'Medical hypotheses', 'Bioscience reports', 'Experimental gerontology', 'Instructional course lectures', 'Regenerative medicine', 'Annals of the New York Academy of Sciences', 'Annals of the New York Academy of Sciences', 'Journal of neurology, neurosurgery, and psychiatry', 'Current pharmaceutical design', 'Annals of the New York Academy of Sciences', 'Annals of the New York Academy of Sciences', 'Neurochemical research', 'Molecular aspects of medicine', 'Clinical chemistry', 'Rejuvenation research', 'Ageing research reviews', 'Pain medicine (Malden, Mass.)', 'Tissue engineering', 'Neurology', 'Movement disorders : official journal of the Movement Disorder Society', 'British journal of pharmacology', 'Medical hypotheses', 'Autophagy', 'Experimental eye research', 'Biochimica et biophysica acta', 'American journal of epidemiology', 'The American journal of geriatric pharmacotherapy', 'Brain research reviews', 'Clinical chemistry', 'The FEBS journal', 'Acta neurobiologiae experimentalis', 'Journal of neural transmission (Vienna, Austria : 1996)', 'The Consultant pharmacist : the journal of the American Society of Consultant Pharmacists', 'International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition', 'Neuroscience', 'Advances in experimental medicine and biology', 'Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology', 'Clinical chemistry', 'Medical hypotheses', 'Neurology', 'BMC neurology', 'American journal of human genetics', 'The Journal of nutrition', "Journal of Alzheimer's disease : JAD", 'Methods and findings in experimental and clinical pharmacology', 'Experimental physiology', 'Current pharmaceutical design', 'Ophthalmic genetics', 'Medical hypotheses', 'Histology and histopathology', 'American journal of therapeutics', 'Antioxidants & redox signaling', 'Clinical and laboratory haematology', 'Amino acids', 'Annals of medicine', 'Current drug targets', 'Neuroscience', 'Progress in neurobiology', 'Biochemical Society transactions', 'Biochimica et biophysica acta', 'The journal of nutrition, health & aging', 'The journal of nutrition, health & aging', 'Neuroscience', 'Journal of neural transmission (Vienna, Austria : 1996)', 'Apoptosis : an international journal on programmed cell death', 'Neurobiology of aging', 'Transplantation', 'Antioxidants & redox signaling', 'The Medical journal of Australia', 'Brain : a journal of neurology', 'Brain : a journal of neurology', 'Current Alzheimer research', 'Nutrition, metabolism, and cardiovascular diseases : NMCD', 'Current opinion in psychiatry', 'Journal of affective disorders', 'Diabetes care', 'Dementia and geriatric cognitive disorders', 'Neurobiology of aging', 'The international journal of biochemistry & cell biology', 'International journal of geriatric psychiatry', 'Panminerva medica', 'Saudi medical journal', 'Journal of the American Dental Association (1939)', 'Experimental gerontology', 'Journal of the neurological sciences', 'Proteomics', 'Current drug metabolism', "Journal of Alzheimer's disease : JAD", 'Neuro-degenerative diseases', 'Chemical senses', 'American journal of speech-language pathology', 'European journal of anaesthesiology', 'Nucleic acids research', 'Neurobiology of disease', 'Autophagy', 'Mutation research', 'Neurotoxicology', 'Chinese medical journal', 'The International journal of neuroscience', 'Trends in neurosciences', 'Journal of neurology, neurosurgery, and psychiatry', 'The neurologist', 'Drugs & aging', 'Sleep medicine', 'Lancet (London, England)', 'NeuroRx : the journal of the American Society for Experimental NeuroTherapeutics', 'Nature', 'Aging cell', 'Neurobiology of aging', 'Toxicology and applied pharmacology', 'Cellular signalling', 'Journal of controlled release : official journal of the Controlled Release Society', 'Neurotoxicity research', 'Journal of neuropathology and experimental neurology', 'IUBMB life', 'Journal of molecular neuroscience : MN', 'Journal of the neurological sciences', 'Drugs & aging', 'Clinical and experimental dermatology', 'Ceskoslovenska patologie', 'Journal of orthopaedic research : official publication of the Orthopaedic Research Society', 'The Journal of neuroscience : the official journal of the Society for Neuroscience', 'Antioxidants & redox signaling', 'Journal of neuropathology and experimental neurology', 'American journal of human biology : the official journal of the Human Biology Council', 'International journal of aging & human development', 'Stereotactic and functional neurosurgery', 'Current medicinal chemistry', 'Journal of orthopaedic surgery (Hong Kong)', 'Nature reviews. Neuroscience', 'Journal of the American Geriatrics Society', 'Current opinion in anaesthesiology', 'Drugs in R&D', 'Medical science monitor : international medical journal of experimental and clinical research', 'Movement disorders : official journal of the Movement Disorder Society', 'Acta neuropathologica', 'Mechanisms of ageing and development', 'Reviews in the neurosciences', 'Journal of neurology', 'Genes, brain, and behavior', 'Nature reviews. Neuroscience', 'Experimental neurology', 'Methods and findings in experimental and clinical pharmacology', 'The American journal of clinical nutrition', 'Neurobiology of aging', 'Aging cell', 'Indian journal of physiology and pharmacology', 'Nuclear medicine review. Central & Eastern Europe', 'NeuroImage', 'Respiration; international review of thoracic diseases', 'Neurology', 'Neurobiology of aging', 'European journal of neurology', 'Critical reviews in toxicology', 'Brain : a journal of neurology', 'The Journal of nutritional biochemistry', 'Journal of neurochemistry', 'IEEE transactions on bio-medical engineering', 'British journal of pharmacology', 'Journal of andrology', 'Annals of the New York Academy of Sciences', 'NeuroRx : the journal of the American Society for Experimental NeuroTherapeutics', 'Current Alzheimer research', 'Molecular therapy : the journal of the American Society of Gene Therapy', 'Acta pharmacologica Sinica', 'Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance', 'Neuroscience', 'Biochemistry', 'Pharmacopsychiatry', 'Journal of pharmacological sciences', 'Medical hypotheses', 'Journal of intellectual disability research : JIDR', 'Neuroscience', 'Current opinion in neurology', 'Neurology', 'Redox report : communications in free radical research', 'Ageing research reviews', 'Psychiatry research', 'Journal of biochemistry and molecular biology', 'Current Alzheimer research', 'Neurobiology of aging', 'Neurobiology of aging', 'Journal of neurochemistry', 'Endocrine', 'Brain research bulletin', 'Journal of pharmacological sciences', 'Arthritis research & therapy', 'The Journal of the Association of Physicians of India', 'The Annals of thoracic surgery', 'DNA repair', 'Osteoarthritis and cartilage', 'Experimental gerontology', 'The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry', 'Current opinion in biotechnology', 'Environmental health perspectives', 'Journal of neurochemistry', 'Journal of molecular evolution', 'Medical hypotheses', 'Aging clinical and experimental research', 'The Journal of biological chemistry', 'Journal of neurochemistry', 'Movement disorders : official journal of the Movement Disorder Society', 'Bioorganic & medicinal chemistry', 'Biochimica et biophysica acta', 'Brain research', 'PLoS biology', 'Journal of neurochemistry', 'Ageing research reviews', 'Free radical research', 'Biogerontology', 'Gene', 'Annual review of nutrition', 'Biomaterials', 'International archives of occupational and environmental health', 'Medical hypotheses', 'Neurobiology of aging', 'Maturitas', 'Neurobiology of aging', 'International journal of psychiatry in medicine', 'Current Alzheimer research', 'Current Alzheimer research', 'Current molecular medicine', 'Drugs & aging', 'Journal of neurology, neurosurgery, and psychiatry', 'Annals of the New York Academy of Sciences', 'NeuroImage', 'Neurobiology of aging', 'The journals of gerontology. Series A, Biological sciences and medical sciences', 'Progress in neurobiology', 'Neuroscience letters', 'Neuropathology and applied neurobiology', 'Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie', 'The American journal of pathology', 'Endocrine reviews', 'Brain research. Brain research reviews', 'Kidney international', 'Proceedings of the National Academy of Sciences of the United States of America', 'Forum of nutrition', 'Neurocase', 'Journal of physiology and pharmacology : an official journal of the Polish Physiological Society', 'Nursing older people', 'Medical hypotheses', 'Neurologic clinics', 'CNS spectrums', 'The international journal of biochemistry & cell biology', 'Journal of neurology', 'International journal of psychophysiology : official journal of the International Organization of Psychophysiology', 'Journal of neural transmission (Vienna, Austria : 1996)', 'Current drug metabolism', 'Neurobiology of aging', 'Journal of physiological anthropology and applied human science', 'Trends in pharmacological sciences', 'Neuroepidemiology', "Journal of Alzheimer's disease : JAD", 'Journal of neural transmission (Vienna, Austria : 1996)', "Journal of Alzheimer's disease : JAD", 'The Journal of neuroscience : the official journal of the Society for Neuroscience', 'American journal of physiology. Cell physiology', 'Neurotoxicity research', 'Neurotoxicity research', 'Neurobiology of aging', 'Neurobiology of aging', 'Mechanisms of ageing and development', 'Biochimica et biophysica acta', "Bulletin et memoires de l'Academie royale de medecine de Belgique", 'Current urology reports', 'Nucleic acids research', 'Journal of neural transmission (Vienna, Austria : 1996)', 'Journal of neural transmission (Vienna, Austria : 1996)', 'Neuroscience', 'Neurobiology of aging', 'Experimental gerontology', 'Experimental gerontology', 'Expert opinion on investigational drugs', 'Journal of the Medical Association of Thailand = Chotmaihet thangphaet', 'Pigment cell research', 'Genomics', 'Romanian journal of internal medicine = Revue roumaine de medecine interne', 'Romanian journal of internal medicine = Revue roumaine de medecine interne', 'The Journal of biological chemistry', "Journal of Alzheimer's disease : JAD", 'Experimental gerontology', 'Neuroscience letters', 'International clinical psychopharmacology', 'Journal of neural transmission (Vienna, Austria : 1996)', 'Clinical orthopaedics and related research', 'Molecular genetics and metabolism', 'Human molecular genetics', 'Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association', 'Alternative medicine review : a journal of clinical therapeutic', 'Trends in neurosciences', 'Trends in neurosciences', 'IUBMB life', 'Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals', 'Journal of neuroimaging : official journal of the American Society of Neuroimaging', 'The Journal of nutritional biochemistry', 'Journal of nuclear medicine : official publication, Society of Nuclear Medicine', 'Antioxidants & redox signaling', 'Journal of molecular biology', 'The neurologist', 'Journal of molecular neuroscience : MN', 'Rejuvenation research', 'Best practice & research. Clinical rheumatology', 'Medical hypotheses', 'Trends in pharmacological sciences', 'Journal of the American Geriatrics Society', 'Acta orthopaedica Scandinavica', 'Journal of proteome research', 'IUBMB life', 'Clinical therapeutics', 'Neurobiology of aging', 'Molecular interventions', 'The Lancet. Neurology', 'Journal of neurovirology', "Journal of Alzheimer's disease : JAD", 'Toxicologic pathology', 'Clinics in geriatric medicine', 'Journal of molecular neuroscience : MN', 'Ageing research reviews', 'Journal of molecular medicine (Berlin, Germany)', 'Neuropathology and applied neurobiology', 'Ageing research reviews', 'Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society', 'Current pharmaceutical design', 'Psychopharmacology bulletin', 'Molecular neurobiology', 'Annals of the New York Academy of Sciences', 'The Journal of biological chemistry', 'The Journal of biological chemistry', 'Cellular and molecular biology (Noisy-le-Grand, France)', 'Clinical autonomic research : official journal of the Clinical Autonomic Research Society', 'Age and ageing', 'The Journal of neuroscience : the official journal of the Society for Neuroscience', 'Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society', 'Health policy (Amsterdam, Netherlands)', 'Sleep medicine', 'Drugs & aging', 'Journal of neurochemistry', 'Human genetics', 'Neurology', 'Seminars in oncology', 'Clinical nutrition (Edinburgh, Scotland)', 'Neurobiology of aging', 'Experimental eye research', 'Medical hypotheses', 'American journal of cardiovascular drugs : drugs, devices, and other interventions', 'Journal of aging & social policy', 'The Lancet. Neurology', 'Journal of neuropathology and experimental neurology', 'The journals of gerontology. Series A, Biological sciences and medical sciences', 'Neurobiology of aging', 'Neurophysiologie clinique = Clinical neurophysiology', 'Neurobiology of learning and memory', 'Drugs', 'Amino acids', 'Journal of geriatric psychiatry and neurology', 'Journal of advanced nursing', 'Australian family physician', 'Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association', 'Journal of pain & palliative care pharmacotherapy', 'Current opinion in cell biology', 'Biochemical Society transactions', 'The Journal of urology', 'Annals of the Academy of Medicine, Singapore', 'Nutrition (Burbank, Los Angeles County, Calif.)', 'Molecular and cellular biochemistry', 'International journal of geriatric psychiatry', 'Progress in neurobiology', 'Free radical biology & medicine', 'Science of aging knowledge environment : SAGE KE', 'Brain research bulletin', 'The spine journal : official journal of the North American Spine Society', 'Metabolism: clinical and experimental', 'Neurochemical research', 'Cellular and molecular biology (Noisy-le-Grand, France)', 'Ageing research reviews', 'European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society', 'Amyotrophic lateral sclerosis and other motor neuron disorders : official publication of the World Federation of Neurology, Research Group on Motor Neuron Diseases', 'Annals of internal medicine', 'The Medical journal of Australia', 'Frontiers in bioscience : a journal and virtual library', 'Science of aging knowledge environment : SAGE KE', 'The Journal of steroid biochemistry and molecular biology', 'IUBMB life', 'Legal medicine (Tokyo, Japan)', 'Proteomics', 'Annals of neurology', 'Aging cell', 'Aging cell', 'Chest', 'The Lancet. Neurology', 'Acta neuropathologica', 'Basic research in cardiology', 'Mutation research', 'Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie', 'Reproductive biology and endocrinology : RB&E', 'The Journal of cardiovascular surgery', 'Quintessence international (Berlin, Germany : 1985)', 'Drug news & perspectives', 'Sante publique (Vandoeuvre-les-Nancy, France)', 'Molecular neurobiology', 'European journal of ophthalmology', 'Neuroscience letters', 'Archives of neurology', 'Neuroscience letters', 'Age and ageing', 'FASEB journal : official publication of the Federation of American Societies for Experimental Biology', 'Brain research. Brain research reviews', 'Biochemical Society transactions', 'Mutation research', 'Arthritis and rheumatism', 'Neurology', 'Medical hypotheses', 'Dementia and geriatric cognitive disorders', 'Radiology', 'Current drug targets', 'Acta neuropathologica', 'Experimental gerontology', 'The Journal of biological chemistry', 'Drugs & aging', 'The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology', 'Apoptosis : an international journal on programmed cell death', 'Toxicology', 'Pharmacotherapy', 'Oncogene', 'Annals of the New York Academy of Sciences', 'Annals of the New York Academy of Sciences', 'Journal of the American Geriatrics Society', 'Acta neuropathologica', 'American journal of ophthalmology', 'Mutation research', 'Aging clinical and experimental research', 'Clinical orthopaedics and related research', 'The journal of nutrition, health & aging', 'The journal of nutrition, health & aging', 'The Journal of comparative neurology', 'Free radical biology & medicine', 'Journal of neurobiology', 'Mutation research', 'Journal of neurology', 'Journal of cellular and molecular medicine', 'Genetic counseling (Geneva, Switzerland)', 'Journal of the International Neuropsychological Society : JINS', 'Neurobiology of aging', 'Neurobiology of aging', 'Journal of neuroscience research', 'Journal of the American Geriatrics Society', 'Journal of neurology', 'Neuropathology and applied neurobiology', 'International journal of geriatric psychiatry', 'Antioxidants & redox signaling', 'Neurochemistry international', 'Neurology', 'Neuropathology and applied neurobiology', 'Neuro endocrinology letters', 'Toxicology', 'Journal of neurochemistry', 'Molecular neurobiology', 'Cell biology international', 'Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography', 'The American journal of psychiatry', 'Journal of the Medical Association of Thailand = Chotmaihet thangphaet', 'International journal of clinical practice', 'CNS drug reviews', 'Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association', 'Methods (San Diego, Calif.)', 'Neuroscience letters', 'Toxicology letters', 'FASEB journal : official publication of the Federation of American Societies for Experimental Biology', 'Ageing research reviews', 'Parkinsonism & related disorders', 'Recent progress in hormone research', 'Biochemical pharmacology', 'Proceedings of the National Academy of Sciences of the United States of America', 'Journal of cognitive neuroscience', 'Current topics in medicinal chemistry', 'Neurobiology of aging', 'Proceedings of the National Academy of Sciences of the United States of America', 'Acta neuropathologica', 'The Australian and New Zealand journal of psychiatry', 'Experimental gerontology', 'Geriatrics', 'Neurological research', 'Biogerontology', 'Neuroscience letters', 'Oncogene', 'Free radical biology & medicine', 'Spine', "American journal of Alzheimer's disease and other dementias", 'European archives of psychiatry and clinical neuroscience', 'Journal of epidemiology and community health', 'Medical hypotheses', 'Current opinion in lipidology', 'Archives of biochemistry and biophysics', 'Annals of the New York Academy of Sciences', 'Annals of the New York Academy of Sciences', 'Journal of neural transmission (Vienna, Austria : 1996)', 'Experimental gerontology', 'International journal of occupational medicine and environmental health', 'International journal of geriatric psychiatry', 'Environmental and molecular mutagenesis', 'Mechanisms of ageing and development', 'Brain research', 'Pediatric neurology', 'The Journal of investigative dermatology', 'Integrative physiological and behavioral science : the official journal of the Pavlovian Society', 'Behavioural brain research', 'Journal of the American College of Nutrition', 'European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society', 'Archives of medical research', 'Journal of the American Geriatrics Society', 'Archives of neurology', 'The European journal of neuroscience', 'Hormones and behavior', 'Mutation research', 'Neuropathology and applied neurobiology', 'Current drug targets', 'American journal of medical genetics', 'Nucleic acids research', 'Journal of neurochemistry', 'The Anatomical record', 'Biochemical Society symposium', 'Mutagenesis', 'Experimental gerontology', 'The Journal of bone and joint surgery. British volume', 'Journal of drug targeting', 'Annals of the Academy of Medicine, Singapore', 'Japanese journal of cancer research : Gann', 'Mutation research', 'Archives of biochemistry and biophysics', 'Annals of neurology', 'Genomics', 'Biological signals and receptors', 'Mechanisms of ageing and development', 'Molecular and cellular biology', 'Medical hypotheses', 'Neuroreport', 'Expert opinion on pharmacotherapy', 'Annals of the New York Academy of Sciences', 'Proceedings of the National Academy of Sciences of the United States of America', 'Biological psychiatry', 'Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association', 'Antioxidants & redox signaling', 'Radiologic clinics of North America', 'European journal of pediatric surgery : official journal of Austrian Association of Pediatric Surgery ... [et al] = Zeitschrift fur Kinderchirurgie', 'Journal of chemical neuroanatomy', 'Journal of neurology', 'Revista de saude publica', 'Mutation research', 'Mechanisms of ageing and development', 'Current opinion in cell biology', 'Electromyography and clinical neurophysiology', 'Endocrinology', 'American journal of human genetics', 'Aging (Milan, Italy)', 'Brain research', 'Biochemistry and cell biology = Biochimie et biologie cellulaire', 'Journal of human hypertension', 'Current opinion in clinical nutrition and metabolic care', 'The Medical journal of Malaysia', 'Experimental gerontology', 'Experimental gerontology', 'Mechanisms of ageing and development', 'The journal of nutrition, health & aging', 'Experimental gerontology', 'Acta orthopaedica Scandinavica. Supplementum', 'Journal of cellular physiology', 'Acta neuropathologica', 'Biological psychiatry', 'Japanese journal of pharmacology', 'Neurobiology of aging', 'Gerontology', 'The Journal of biological chemistry', 'Environmental health perspectives', 'Alzheimer disease and associated disorders', 'Brain research', 'Annals of the New York Academy of Sciences', 'International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience', 'European journal of biochemistry', 'Medical hypotheses', 'Osteoarthritis and cartilage', 'European neurology', 'Neuroimmunomodulation', 'Harvard review of psychiatry', 'Progress in neurobiology', 'Clinical and experimental dermatology', 'Brain research', 'Biological psychiatry', 'Journal of epidemiology and biostatistics', 'The New Zealand dental journal', 'Journal of submicroscopic cytology and pathology', 'Zeitschrift fur Naturforschung. C, Journal of biosciences', 'Clinical anatomy (New York, N.Y.)', 'Brain research. Developmental brain research', 'Annals of the New York Academy of Sciences', 'Methods and findings in experimental and clinical pharmacology', "Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde", 'European archives of psychiatry and clinical neuroscience', 'Brain : a journal of neurology', 'Journal of applied physiology (Bethesda, Md. : 1985)', 'Neurobiology of aging', 'Biochemical and biophysical research communications', 'Drugs & aging', 'Drugs & aging', 'Proceedings of the National Academy of Sciences of the United States of America', 'Sports medicine (Auckland, N.Z.)', 'The Psychiatric clinics of North America', 'Neuroscience letters', 'Journal of neuroscience research', 'Archives of neurology', 'European journal of biochemistry', 'Free radical biology & medicine', 'Journal of neurology', 'Acta neuropathologica', 'Drugs & aging', 'Bioelectrochemistry and bioenergetics (Lausanne, Switzerland)', 'Journal of neural transmission. Supplementum', 'Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas', 'The Proceedings of the Nutrition Society', 'Acta neuropathologica', 'Veterinary pathology', 'Journal of molecular biology', 'Neurology', 'Acupuncture & electro-therapeutics research', 'Biological psychiatry', 'Movement disorders : official journal of the Movement Disorder Society', 'Annual review of medicine', 'Science (New York, N.Y.)', 'Proceedings of the National Academy of Sciences of the United States of America', 'Annals of the New York Academy of Sciences', 'Annals of the New York Academy of Sciences', 'Annals of the New York Academy of Sciences', 'Annals of the New York Academy of Sciences', 'Clinics in laboratory medicine', 'Genome research', 'Herz', 'Mutation research', 'Brain research. Molecular brain research', 'Microscopy research and technique', 'Biochemical pharmacology', 'International clinical psychopharmacology', 'Journal of neurochemistry', 'Cerebral cortex (New York, N.Y. : 1991)', 'Geriatrics', 'Brain research', 'Journal of neuroscience research', 'Journal of neural transmission (Vienna, Austria : 1996)', 'Neurology', 'Human molecular genetics', 'Biological psychiatry', 'Neurology', 'The American journal of medicine', 'Nucleic acids research', 'Journal of clinical pathology', 'Journal of the American Geriatrics Society', 'Functional neurology', 'Brain : a journal of neurology', 'Instructional course lectures', 'Journal of neuroscience research', 'Environmental health perspectives', 'Magnesium research', 'Mechanisms of ageing and development', 'The American journal of psychiatry', 'Acta neuropathologica', 'Urology', 'Archives of physical medicine and rehabilitation', 'Trends in neurosciences', 'Molecular and chemical neuropathology', 'Biological psychiatry', 'IEEE transactions on rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society', 'Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)', 'Proceedings of the National Academy of Sciences of the United States of America', 'Drugs & aging', 'Current biology : CB', 'Journal of the Formosan Medical Association = Taiwan yi zhi', 'Annals of the New York Academy of Sciences', "Bailliere's clinical endocrinology and metabolism", 'Archives of dermatology', 'Aging (Milan, Italy)', 'Archives of neurology', 'Sports medicine (Auckland, N.Z.)', 'Neurobiology of aging', 'Neurobiology of aging', 'Experimental gerontology', 'Biochemical pharmacology', 'Human molecular genetics', 'Neuroreport', 'Brain research', 'Collegium antropologicum', 'Regional anesthesia', 'Forensic science international', 'Dementia and geriatric cognitive disorders', 'Folia neuropathologica', 'New directions for mental health services', 'Molecular and chemical neuropathology', 'Postgraduate medical journal', 'Methods and findings in experimental and clinical pharmacology', 'Age and ageing', 'European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP)', 'Seizure', 'Clinical therapeutics', 'Drugs & aging', 'Journal of molecular medicine (Berlin, Germany)', 'Archives of internal medicine', 'Analytical biochemistry', 'Microscopy research and technique', 'International review of neurobiology', 'Neurobiology of aging', 'Instructional course lectures', 'Mutation research', 'Neuroscience letters', 'Cellular and molecular biology (Noisy-le-Grand, France)', 'Acta neuropathologica', 'Clinical neuropathology', 'Therapie', 'British medical bulletin', 'Medical hypotheses', 'Diabetes & metabolism', 'American journal of respiratory and critical care medicine', 'Neurobiology of aging', 'Journal of neurochemistry', 'Annals of the New York Academy of Sciences', 'Journal of the American Geriatrics Society', 'Nature genetics', 'Archives of neurology', 'Neuropharmacology', 'Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics', 'JPEN. Journal of parenteral and enteral nutrition', 'The Journal of nutrition', 'Annals of the New York Academy of Sciences', 'Biochemical and biophysical research communications', 'Stroke', 'IARC scientific publications', 'Neurosurgical review', 'Journal of neural transmission (Vienna, Austria : 1996)', 'European journal of clinical nutrition', 'Journal of neural transmission. Supplementum', 'Journal of neural transmission. Supplementum', 'Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA', 'Research quarterly for exercise and sport', 'Life sciences', 'Brain research. Molecular brain research', 'Methods and findings in experimental and clinical pharmacology', 'Journal of spinal disorders', 'Journal of manipulative and physiological therapeutics', 'Neuroreport', 'The journals of gerontology. Series A, Biological sciences and medical sciences', 'Experimental neurology', 'Mayo Clinic proceedings', 'Proceedings of the National Academy of Sciences of the United States of America', 'Journal of the Royal College of Physicians of London', 'The Journal of rheumatology', 'Annals of the Academy of Medicine, Singapore', 'Investigative ophthalmology & visual science', 'FASEB journal : official publication of the Federation of American Societies for Experimental Biology', 'Journal of neuropathology and experimental neurology', 'Toxicology and applied pharmacology', 'Clinical orthopaedics and related research', 'Annals of neurology', 'Biochimica et biophysica acta', "Comptes rendus de l'Academie des sciences. Serie III, Sciences de la vie", 'Leukemia', 'The Journal of comparative neurology', 'Annual review of genetics', 'Annual review of genetics', 'International psychogeriatrics', 'Archives of dermatological research', 'The American journal of pathology', 'Annals of neurology', 'Investigative ophthalmology & visual science', 'Journal of neuropathology and experimental neurology', 'Critical care clinics', 'Biology of reproduction', 'Neuroimaging clinics of North America', 'Hormone research', 'The American journal of pathology', 'Drugs & aging', 'Biochemistry and molecular biology international', 'Australian and New Zealand journal of ophthalmology', 'The Journal of neuroscience : the official journal of the Society for Neuroscience', 'The American journal of clinical nutrition', 'The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society', 'Free radical biology & medicine', 'Annals of neurology', 'The Western journal of medicine', 'Neuroreport', 'Life sciences', 'Southern medical journal', 'Acta psychiatrica Scandinavica', 'Drugs & aging', 'Brain research', 'Brain pathology (Zurich, Switzerland)', 'Neurochemistry international', 'Neurochemistry international', 'Spine', 'Aging (Milan, Italy)', 'Journal of child neurology', 'Progress in neuro-psychopharmacology & biological psychiatry', 'Life sciences', 'Acta anatomica', 'Journal of neural transmission. Supplementum', 'Journal of neural transmission. Supplementum', 'Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie', 'Archives of dermatological research', 'Acta neuropathologica', 'Acta neurobiologiae experimentalis', 'Advances in experimental medicine and biology', 'Geriatrics', 'Public health', 'Current opinion in neurobiology', 'Journal of toxicology and environmental health', 'Annals of neurology', 'Bollettino della Societa italiana di biologia sperimentale', 'Stem cells (Dayton, Ohio)', 'Virchows Archiv. A, Pathological anatomy and histopathology', 'Clinics in geriatric medicine', 'Archives of ophthalmology (Chicago, Ill. : 1960)', 'Clinics in podiatric medicine and surgery', 'Biological psychiatry', 'Molecular and cellular biochemistry', 'Archives of pathology & laboratory medicine', 'Journal of clinical and experimental neuropsychology', 'Neurology', 'Cardiovascular clinics', 'Journal of reproduction and fertility. Supplement', 'Virchows Archiv. A, Pathological anatomy and histopathology', 'Psychopharmacology', 'Annals of the New York Academy of Sciences', 'Carcinogenesis', 'Paraplegia', 'Journal of gerontology', 'Nature', 'Current opinion in rheumatology', 'Neuroscience', 'Journal of the American College of Nutrition', 'Postgraduate medicine', 'Journal of the American College of Nutrition', 'Drugs & aging', 'Clinical orthopaedics and related research', 'Mutation research', 'Mutation research', 'Mutation research', 'Suicide & life-threatening behavior', 'The American journal of medicine', 'EXS', 'EXS', 'Mutation research', 'The Southeast Asian journal of tropical medicine and public health', 'EXS', 'Health policy (Amsterdam, Netherlands)', 'Medical anthropology', 'Mutation research', 'Mechanisms of ageing and development', 'Comprehensive therapy', 'The Journal of comparative neurology', 'The American journal of clinical nutrition', 'Journal of neurology, neurosurgery, and psychiatry', 'Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)', 'Clinics in sports medicine', 'Neurochemical research', 'Seminars in arthritis and rheumatism', 'Science (New York, N.Y.)', 'Aging (Milan, Italy)', 'Rheumatic diseases clinics of North America', 'Biochemistry international', 'Neurotoxicology', 'Neurology', 'Journal of the neurological sciences', 'Age and ageing', 'Journal of the neurological sciences', 'Proceedings of the National Academy of Sciences of the United States of America', 'Neuroscience letters', 'Health services research', 'Experimental gerontology', 'Research in developmental disabilities', 'FASEB journal : official publication of the Federation of American Societies for Experimental Biology', 'Lancet (London, England)', 'The American journal of pathology', 'Genome', 'Annals of the New York Academy of Sciences', 'Progress in growth factor research', 'Annals of medicine', 'Postgraduate medicine', 'The New Zealand medical journal', 'Annals of neurology', 'The American journal of medicine', 'The Journal of foot surgery', 'Age and ageing', 'British journal of hospital medicine', 'Advances in neurology', 'Postgraduate medicine', 'Surgical neurology', 'The American journal of medicine', 'Sports medicine (Auckland, N.Z.)', 'The Journal of otolaryngology', 'Ophthalmology', 'American journal of physical anthropology', 'Arthritis and rheumatism', 'The American journal of medicine', 'Clinics in gastroenterology', 'Gerontology', 'Documenta ophthalmologica. Advances in ophthalmology', 'Annals of neurology', 'Psychological medicine', 'International rehabilitation medicine', 'Neurobiology of aging', 'Journal of neural transmission', 'Journal of neurophysiology', 'International dental journal', 'Journal of toxicology. Clinical toxicology', 'Advances in veterinary science and comparative medicine', 'Mechanisms of ageing and development', 'International dental journal', 'Neurobiology of aging', 'Medical instrumentation', 'Federation proceedings', 'The Veterinary clinics of North America. Small animal practice', 'Proceedings of the National Academy of Sciences of the United States of America', 'Age and ageing', 'Reviews of infectious diseases', 'The Quarterly journal of medicine', 'International journal of obesity', 'Biological psychiatry', 'Journal of the American Geriatrics Society', 'Contemporary neurology series', 'Journal of the American Geriatrics Society', 'Oral surgery, oral medicine, and oral pathology', 'Angiology', 'The Practitioner', 'Canadian Medical Association journal', 'Acta neuropathologica communications', 'International journal of molecular sciences', 'Nature neuroscience', 'Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)', 'Frontiers in immunology', 'Proceedings of the National Academy of Sciences of the United States of America', 'Frontiers in immunology', 'Methods in molecular biology (Clifton, N.J.)', 'Neural plasticity', 'Canadian journal of physiology and pharmacology', 'Cell reports', 'International journal of molecular sciences', 'International journal of molecular sciences', 'International journal of environmental research and public health', 'International journal of environmental research and public health', 'Biomolecules', 'Topics in antiviral medicine', 'Scientific reports', 'The Journal of experimental medicine', 'Acta neuropathologica communications', 'Frontiers in endocrinology', 'Fluids and barriers of the CNS', 'Journal of orthopaedic surgery and research', 'Nature neuroscience', 'The Journal of neuroscience : the official journal of the Society for Neuroscience', 'Nutrients', 'Nutrients', 'Molecules (Basel, Switzerland)', 'International journal of molecular sciences', 'Cells', 'ACS chemical neuroscience', 'Chemical communications (Cambridge, England)', 'The Lancet. Healthy longevity', 'Oxidative medicine and cellular longevity', 'Scientific reports', 'Nature communications', 'The Journal of neuroscience : the official journal of the Society for Neuroscience', 'The Journal of neuroscience : the official journal of the Society for Neuroscience', 'Ageing research reviews', "Alzheimer's research & therapy", 'Molecules (Basel, Switzerland)', 'International journal of molecular sciences', 'International journal of environmental research and public health', "Alzheimer's research & therapy", 'Journal of neuroimmunology', 'Ageing research reviews', 'Aging cell', 'Hearing research', 'Neurobiology of disease', 'The Journal of biological chemistry', 'Neurobiology of aging', 'Nature communications', 'Journal of clinical hypertension (Greenwich, Conn.)', 'Free radical biology & medicine', 'Proceedings of the National Academy of Sciences of the United States of America', 'Neurobiology of aging', 'Free radical biology & medicine', 'International journal of molecular sciences', 'International journal of molecular sciences', 'International journal of molecular sciences', 'Journal of integrative neuroscience', 'Mediators of inflammation', 'eLife', 'Neurobiology of aging', 'Medical image analysis', 'BMC geriatrics', 'The Lancet. Healthy longevity', 'Experimental eye research', 'JAMA network open', 'Brain research', 'Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference', 'Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference', 'Molecular neurobiology', 'Nutrients', 'International journal of molecular sciences', 'International journal of molecular sciences', 'BMC medicine', 'Oxidative medicine and cellular longevity', 'BMC anesthesiology', 'Cell reports', 'Cancer research', 'Journal of neuroinflammation', 'Acta neuropathologica', 'PLoS computational biology', 'Annals of neurology', 'Disease models & mechanisms', 'Biogerontology', 'Nutrition bulletin', 'Epigenomics', 'Genome research', 'Oxidative medicine and cellular longevity', 'Ageing research reviews', 'International journal of molecular sciences', 'International journal of molecular sciences', "Alzheimer's research & therapy", 'NeuroImage', 'Physical medicine and rehabilitation clinics of North America', 'Aging cell', 'Journal of glaucoma', 'Mutation research. Reviews in mutation research', 'Molecular neurobiology', 'Experimental neurology', 'Acta neuropathologica communications', 'Computational intelligence and neuroscience', 'Stem cell research', 'Acta neuropathologica communications', 'Biomechanics and modeling in mechanobiology', 'Computers in biology and medicine', 'Immunity', 'Age and ageing', 'The Journal of comparative neurology', 'Neurology', 'BMC musculoskeletal disorders', 'Journal of clinical and experimental neuropsychology', 'Theranostics', 'Australian journal of general practice', 'Ageing research reviews', 'Computers in biology and medicine', 'Neurobiology of aging', 'JAMA neurology', 'Cells', 'Molecules (Basel, Switzerland)', 'International journal of molecular sciences', 'Neuron', 'Experimental brain research', 'Talanta', 'Mechanisms of ageing and development', 'Proceedings of the National Academy of Sciences of the United States of America', 'BMC geriatrics', 'Cellular and molecular life sciences : CMLS', 'Nature cell biology', 'Neuroimaging clinics of North America', 'Neurobiology of disease', 'Neurobiology of aging', 'Neurochemistry international', 'Journal of neuroimaging : official journal of the American Society of Neuroimaging', 'Journal of the American Geriatrics Society', 'Journal of neural transmission (Vienna, Austria : 1996)', 'Hand (New York, N.Y.)', 'Neuroscience and biobehavioral reviews', 'Hormones and behavior', 'Brain : a journal of neurology', 'Nutrients', 'International journal of molecular sciences', 'Molecules (Basel, Switzerland)', 'Research in veterinary science', 'The journals of gerontology. Series A, Biological sciences and medical sciences', 'Molecular biology reports', 'Neurology', 'Annals of clinical and translational neurology', 'Food & function', 'Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology', 'Neurobiology of disease', 'Aging cell', 'Mechanisms of ageing and development', 'Journal of internal medicine', 'Neuroscience', 'Brain pathology (Zurich, Switzerland)', 'Neurobiology of aging', 'Journal of dental research', 'Trends in neurosciences', 'Alternative therapies in health and medicine', 'Neurobiology of aging', 'Neurobiology of disease', 'Journal of neurovirology', 'Methods (San Diego, Calif.)', 'Human molecular genetics', 'Molecular and cellular neurosciences', 'GeroScience', 'Neurotoxicity research', 'Aging cell', 'Gait & posture', 'Epigenetics', 'Developmental medicine and child neurology', 'Lower urinary tract symptoms', 'Environmental science and pollution research international', 'Stem cell reviews and reports', 'Macromolecular bioscience', 'Journal of food biochemistry', 'Antioxidants & redox signaling', 'Reviews in the neurosciences', 'Pharmacology & therapeutics', 'Journal of sleep research', 'Neuroinformatics', 'Nature reviews. Immunology', 'Brain pathology (Zurich, Switzerland)', 'Experimental eye research', "Alzheimer's research & therapy", 'Translational neurodegeneration', 'Scientific reports', 'International journal of molecular sciences', 'International journal of molecular sciences', 'International journal of molecular sciences', 'International journal of molecular sciences', "Women's health (London, England)", 'Frontiers in immunology', 'Internal medicine journal', 'ASN neuro', 'Scientific reports', 'Communications biology', 'Handbook of clinical neurology', 'Handbook of clinical neurology', 'Phytomedicine : international journal of phytotherapy and phytopharmacology', 'Handbook of clinical neurology', 'The Journal of clinical investigation', 'Nutrients', 'International journal of molecular sciences', 'International journal of molecular sciences', 'International journal of molecular sciences', 'International journal of molecular sciences', 'International journal of molecular sciences', 'Cells', 'Cells', 'International immunopharmacology', 'NeuroImage', 'Journal of bioenergetics and biomembranes', 'Fluids and barriers of the CNS', 'International clinical psychopharmacology', 'Scientific data', 'Phytotherapy research : PTR', 'Talanta', 'Analytical and bioanalytical chemistry', 'Genetics', 'Viruses', 'Nutrients', 'Medicina (Kaunas, Lithuania)', 'International journal of environmental research and public health', 'Neuroscience letters', 'PloS one', 'Cell death & disease', 'Current protocols', 'Neurobiology of aging', 'Cell reports', 'Scientific reports', 'BMC medical research methodology', 'Journal of enzyme inhibition and medicinal chemistry', 'Neurobiology of disease', 'Nutrients', 'International journal of molecular sciences', 'International journal of molecular sciences', 'International journal of molecular sciences', 'International journal of molecular sciences', 'Cells', 'Clinical biomechanics (Bristol, Avon)', 'Neurobiology of disease', 'Sub-cellular biochemistry', 'Sub-cellular biochemistry', 'Sub-cellular biochemistry', 'Neurobiology of aging', 'eNeuro', 'Physics in medicine and biology', 'Neuroscience letters', 'Journal of the neurological sciences', 'Human brain mapping', 'BMC veterinary research', 'BMC neurology', 'Experimental gerontology', 'Molecules and cells', 'NeuroImage', 'Maturitas', 'Brain, behavior, and immunity', 'ACS chemical neuroscience', 'Neurology(R) neuroimmunology & neuroinflammation', 'Science advances', "Alzheimer's & dementia : the journal of the Alzheimer's Association", 'GeroScience', 'Acta neuropathologica', 'Clinical science (London, England : 1979)', 'Signal transduction and targeted therapy', 'The Lancet. Neurology', 'Translational vision science & technology', 'Aging cell', 'JAMA neurology', 'Expert opinion on therapeutic targets', "Journal of Alzheimer's disease : JAD", 'Molecules (Basel, Switzerland)', 'Cells', 'Translational psychiatry', 'Journal of agricultural and food chemistry', 'Journal of preventive medicine and hygiene', 'Cell reports', 'European journal of pharmacology', 'Human brain mapping', 'Neurology', 'Experimental neurology', 'Sleep', 'Journal of affective disorders', 'Neuroscience and biobehavioral reviews', 'NeuroImage', 'Archives of biochemistry and biophysics', 'The Lancet. Neurology', 'Journal of neuroscience methods', 'Journal of food biochemistry', 'Journal of neurology', 'JAMA neurology', 'Mitochondrion', 'World neurosurgery', 'NeuroImage', 'Brain research bulletin', "Alzheimer's & dementia : the journal of the Alzheimer's Association", 'Metabolic brain disease', 'JAMA neurology', 'Annals of neurology', 'Journal of nuclear medicine : official publication, Society of Nuclear Medicine', 'Journal of internal medicine', 'Human brain mapping', 'Molecular psychiatry', 'NeuroImage', 'Trends in biochemical sciences', 'Journal of the American Geriatrics Society', 'Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism', 'Human brain mapping', 'Arthritis & rheumatology (Hoboken, N.J.)', 'Sleep', 'Journal of the American Geriatrics Society', 'European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery', 'Neurochemical research', 'Cancer medicine', 'GeroScience', 'GeroScience', 'The journals of gerontology. Series A, Biological sciences and medical sciences', 'Brain : a journal of neurology', 'The journals of gerontology. Series A, Biological sciences and medical sciences', "Alzheimer's & dementia : the journal of the Alzheimer's Association", 'Journal of neurology', 'Neuroscience bulletin', 'Current medicinal chemistry', 'Current drug safety', 'Current topics in behavioral neurosciences', 'Ophthalmic epidemiology', 'The journals of gerontology. Series A, Biological sciences and medical sciences', 'The European journal of neuroscience', 'Biotechnology and applied biochemistry', 'Cerebral cortex (New York, N.Y. : 1991)', 'Natural product research', 'Brain : a journal of neurology', 'Clinical reviews in allergy & immunology', 'Critical reviews in biotechnology', 'Cellular and molecular neurobiology', 'The journals of gerontology. Series A, Biological sciences and medical sciences', 'The Clinical neuropsychologist', 'Seminars in thoracic and cardiovascular surgery', 'Aging & mental health', 'Acta neurologica Belgica', 'Cell biology and toxicology', 'Nutritional neuroscience', 'Applied neuropsychology. Adult', 'Environmental health : a global access science source', 'ACS chemical neuroscience', 'International journal of molecular sciences', 'International journal of molecular sciences', 'Stem cell research & therapy', 'NeuroImage', 'Communications biology', 'Frontiers in endocrinology', 'Life sciences', 'BMC geriatrics', 'Journal of hypertension', 'Biochemical Society transactions', 'JAMA network open', 'Sleep medicine', 'BMC geriatrics', 'EBioMedicine', 'Journal of integrative neuroscience', 'BMC geriatrics', 'Nutrients', 'International journal of molecular sciences', 'Molecules (Basel, Switzerland)', 'International journal of molecular sciences', 'Biomolecules', 'Biomolecules', 'Marine drugs', 'Frontiers in endocrinology', 'Scientific reports', 'Disease-a-month : DM', 'Science advances', 'Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie', 'Neurobiology of aging', 'Journal of orthopaedic surgery and research', 'Trends in neurosciences', 'Nutrients', 'International journal of molecular sciences', 'International journal of molecular sciences', 'International journal of molecular sciences', 'International journal of environmental research and public health', 'Cells', 'Cells', 'Environmental research', 'Neuroscience', 'American journal of physiology. Cell physiology', 'Neurobiology of aging', 'Neuropharmacology', 'Stroke', 'European journal of epidemiology', 'Aging cell', 'Biogerontology', 'Journal of molecular neuroscience : MN', 'Psychopharmacology', 'Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association', 'Annals of clinical and translational neurology', 'Advanced science (Weinheim, Baden-Wurttemberg, Germany)', 'Experimental biology and medicine (Maywood, N.J.)', 'Acta neuropathologica', 'Journal of neuroscience research', 'Metabolic brain disease', 'Advanced science (Weinheim, Baden-Wurttemberg, Germany)', 'The Journal of biological chemistry', 'Neurotoxicity research', 'Journal of neurochemistry', 'The spine journal : official journal of the North American Spine Society', 'WIREs mechanisms of disease', 'Biomolecules and biomedicine', 'Chronobiology international', 'Apoptosis : an international journal on programmed cell death', 'Medical physics', 'Human molecular genetics', 'Brain pathology (Zurich, Switzerland)', "Alzheimer's & dementia : the journal of the Alzheimer's Association", 'Neuromolecular medicine', 'Cerebral cortex (New York, N.Y. : 1991)', 'Alcohol (Fayetteville, N.Y.)', 'Nutritional neuroscience', 'Current rheumatology reviews', "Journal of Alzheimer's disease : JAD", 'MicroRNA (Shariqah, United Arab Emirates)', 'Nigerian journal of clinical practice', 'International journal of molecular sciences', 'IUBMB life', 'IEEE journal of biomedical and health informatics', 'Nature communications', 'Disability and rehabilitation', 'PLoS medicine', 'Neurobiology of disease', 'PLoS genetics', 'Genetics and molecular research : GMR', 'Seminars in cell & developmental biology', 'Journal of neurosurgery. Spine', 'Sheng li xue bao : [Acta physiologica Sinica]', 'Current molecular medicine', 'Current opinion in anaesthesiology', 'Expert opinion on therapeutic patents', 'Biochimica et biophysica acta', 'Proceedings of the National Academy of Sciences of the United States of America', 'Experimental neurology', 'International journal of environmental research and public health', 'Human molecular genetics', 'Environmental pollution (Barking, Essex : 1987)', 'CNS & neurological disorders drug targets', 'Nature aging', 'Molecular genetics and metabolism', 'Nutrients', 'European journal of pharmacology', 'Acta neuropathologica communications', 'Acta neuropathologica communications', 'Journal of neurology, neurosurgery, and psychiatry', 'Human molecular genetics', 'Neurology', 'Heart, lung & circulation', 'Molecular therapy : the journal of the American Society of Gene Therapy', 'Neurobiology of aging', 'Stress (Amsterdam, Netherlands)', 'Cellular and molecular neurobiology', 'Reviews in the neurosciences', 'Nutritional neuroscience', "Journal of Alzheimer's disease : JAD", 'Glia', 'Nature communications', 'Scientific reports', 'International journal of cardiology', 'Molecular medicine reports', 'International journal of molecular sciences', 'Revista da Sociedade Brasileira de Medicina Tropical', 'Nature neuroscience', 'Nature cell biology', 'Drug discovery today', 'Current biology : CB', 'Pediatrics', 'International journal of molecular sciences', 'Ageing research reviews', 'European review for medical and pharmacological sciences', 'Blood', 'Biochemical and biophysical research communications', 'Stem cell research & therapy', 'PloS one', 'Current hypertension reports', 'The Journal of biological chemistry', 'Human molecular genetics', 'PloS one', 'European neurology', 'Journal of neural transmission. Supplementum', "Journal of Alzheimer's disease : JAD", 'The lancet. Healthy longevity', 'International journal of biometeorology', 'International journal of molecular sciences', 'BMC health services research', 'International journal of molecular sciences', 'Cellular and molecular life sciences : CMLS', 'Inflammopharmacology', 'Brain : a journal of neurology', 'Journal of neurodevelopmental disorders', 'Current neurology and neuroscience reports', 'Current medicinal chemistry', 'Free radical biology & medicine', 'PloS one', 'Orphanet journal of rare diseases', 'Neurotoxicity research', 'International journal of molecular sciences', 'Journal of neurogenetics', 'The Medical journal of Australia', 'European journal of epidemiology', 'Disease models & mechanisms', 'Australian journal of general practice', 'The Journal of pathology', 'Current pharmaceutical design', 'Brain : a journal of neurology', 'Anthropologischer Anzeiger; Bericht uber die biologisch-anthropologische Literatur', 'Experimental neurology', 'Nature genetics', 'European journal of nutrition', 'NeuroImage. Clinical', 'Current stem cell research & therapy', 'Acta neuropathologica communications', 'The Nursing clinics of North America', 'Current protein & peptide science', 'Chest', 'Human molecular genetics', 'The Annals of thoracic surgery', 'Current pharmaceutical design', 'Scientific reports', 'International journal of molecular sciences', 'PLoS genetics', 'Blood', 'Human molecular genetics', 'Proceedings of the National Academy of Sciences of the United States of America', 'Molecular neurobiology', 'Brain topography', 'Mutation research', 'The journal of nutrition, health & aging', 'Neuroscience and biobehavioral reviews', "Journal of Alzheimer's disease : JAD", 'Neurobiology of disease', "Alzheimer's & dementia : the journal of the Alzheimer's Association", 'The spine journal : official journal of the North American Spine Society', 'Genes', 'PLoS genetics', 'Metabolic brain disease', 'Cells', 'Nature communications', 'Acta neuropathologica communications', 'Applied neuropsychology. Adult', 'Neuroscience bulletin', 'Reviews on environmental health', 'Human molecular genetics', 'Neurobiology of aging', 'Current medicinal chemistry', 'Psychoneuroendocrinology', 'Proceedings of the National Academy of Sciences of the United States of America', 'Journal of neurochemistry', 'Movement disorders : official journal of the Movement Disorder Society', 'Neurochemistry international', 'Clinical genetics', 'Nature medicine', 'Neurobiology of disease', 'Clinical infectious diseases : an official publication of the Infectious Diseases Society of America', 'Nutritional neuroscience', 'Practical neurology', 'Human molecular genetics', 'Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia', 'Behavioural neurology', 'Brain : a journal of neurology', 'Proceedings of the National Academy of Sciences of the United States of America', 'Human molecular genetics', 'Current topics in medicinal chemistry', 'Human molecular genetics', 'Journal of neurochemistry', 'Nature reviews. Drug discovery', 'Proceedings of the National Academy of Sciences of the United States of America', 'NeuroRehabilitation', 'Annals of surgery', 'International journal of molecular sciences', 'Gaceta medica de Mexico', 'IEEE/ACM transactions on computational biology and bioinformatics', 'Current opinion in pulmonary medicine', 'Plant foods for human nutrition (Dordrecht, Netherlands)', 'Medicina (Kaunas, Lithuania)', 'Epilepsy & behavior : E&B', 'Current medicinal chemistry', 'Journal of the neurological sciences', "Journal of Alzheimer's disease : JAD", 'Oncotarget', 'Annales pharmaceutiques francaises', 'PLoS computational biology', 'Pediatric research', 'Neuroscience', 'Clinical orthopaedics and related research', 'The Urologic clinics of North America', 'Journal of neurology', "The journal of prevention of Alzheimer's disease", "Journal of Alzheimer's disease : JAD", "Journal of Alzheimer's disease : JAD", 'Journal of the International Neuropsychological Society : JINS', 'Neuroscience and biobehavioral reviews', 'British journal of pharmacology', 'Reviews in the neurosciences', 'NeuroImage. Clinical', 'Human molecular genetics', 'Scientific reports', 'The Journal of biological chemistry', 'Psychiatria Danubina', 'Journal of environmental monitoring : JEM', 'Pediatric research', 'Nature clinical practice. Neurology', 'Reviews in the neurosciences', 'Human molecular genetics', 'Hormone research', 'Journal of palliative care', 'Review of public data use', 'International journal of molecular sciences', 'Nigerian journal of physiological sciences : official publication of the Physiological Society of Nigeria', 'ASN neuro', 'eLife', 'Neurology', 'The bone & joint journal', 'Experimental gerontology', 'PloS one', 'PloS one', 'Acta cardiologica', 'Brain research', 'Neuro-degenerative diseases', 'European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society', 'Brain structure & function', 'Clinical genetics', 'Social science & medicine (1982)', 'Autophagy', 'CNS & neurological disorders drug targets', 'European journal of epidemiology', 'Journal of neuroimaging : official journal of the American Society of Neuroimaging', 'The Clinical neuropsychologist', 'Journal of neurogenetics', 'eLife', 'Current medicinal chemistry', 'Biochemistry. Biokhimiia', "Alzheimer's & dementia : the journal of the Alzheimer's Association", 'International review of neurobiology', 'Current Alzheimer research', 'PloS one', 'American journal of human genetics', 'Nutricion hospitalaria', 'Human molecular genetics', 'Human molecular genetics', 'The Journal of neuroscience : the official journal of the Society for Neuroscience', 'Nature reviews. Molecular cell biology', 'Anesthesiology clinics', 'Neuropsychological rehabilitation', 'Current neuropharmacology', 'Free radical biology & medicine', 'Nature communications', 'BMJ open', 'Cell metabolism', 'Toxins', 'Acta neuropathologica', 'Carcinogenesis', 'Progress in neuro-psychopharmacology & biological psychiatry', 'CNS & neurological disorders drug targets', 'Nature reviews. Neurology', 'Brain research bulletin', 'Human molecular genetics', 'Journal of neural transmission. Supplementum', 'The American journal of drug and alcohol abuse', 'Nature communications', 'Biomaterials', 'Acta neuropathologica communications', 'Brain pathology (Zurich, Switzerland)', 'BMJ open', 'Molecular genetics and metabolism', "Journal of Alzheimer's disease : JAD", 'Progress in neurobiology', 'Molecular therapy : the journal of the American Society of Gene Therapy', 'Brain : a journal of neurology', 'Biomedical and environmental sciences : BES', 'International journal of molecular sciences', 'Reproduction & fertility', 'Biosensors', 'International journal of molecular sciences', 'Acta neuropathologica communications', 'Gene therapy', 'Journal of neuroscience methods', 'Endocrine, metabolic & immune disorders drug targets', 'Journal of palliative medicine', 'Molecular and cellular neurosciences', 'Journal of cellular and molecular medicine', 'Acta neurochirurgica', 'Nutrients', 'Cerebral cortex (New York, N.Y. : 1991)', 'Technology in cancer research & treatment', 'Current Alzheimer research', 'Seminars in immunology', 'Human molecular genetics', 'The Journal of comparative neurology', 'Disease models & mechanisms', 'Cortex; a journal devoted to the study of the nervous system and behavior', 'Current Alzheimer research', "Journal of Parkinson's disease", 'PloS one', 'Virology journal', 'Archives of physical medicine and rehabilitation', 'Annals of neurology', 'American journal of obstetrics and gynecology', 'Current opinion in cell biology', 'Journal of molecular medicine (Berlin, Germany)', 'Anatomical record (Hoboken, N.J. : 2007)', 'Experimental neurology', 'Wiener klinische Wochenschrift', 'Turk psikiyatri dergisi = Turkish journal of psychiatry', 'Journal of magnetic resonance imaging : JMRI', 'NeuroImage', 'Journal of neurovirology', 'Brain connectivity', 'BMC geriatrics', 'Critical reviews in food science and nutrition', 'Neuron', 'Physiological research', 'Brain : a journal of neurology', 'Clinical immunology (Orlando, Fla.)', 'Journal of endocrinological investigation', 'Proceedings of the National Academy of Sciences of the United States of America', 'Proceedings of the National Academy of Sciences of the United States of America', 'Brain : a journal of neurology', 'Klinische Monatsblatter fur Augenheilkunde', 'Progress in growth factor research', 'Current medicinal chemistry', 'PloS one', 'Journal of neurovirology', 'Frontiers in neuroendocrinology', 'Expert opinion on therapeutic patents', 'Current topics in developmental biology', 'Human molecular genetics', 'CNS & neurological disorders drug targets', 'The Journal of biological chemistry', 'Reviews in the neurosciences', 'Canadian journal of public health = Revue canadienne de sante publique', 'Current pharmaceutical design', 'Current pharmaceutical design', 'Disability and rehabilitation', 'PLoS medicine', 'International journal of molecular sciences', 'Acta neuropathologica communications', 'Movement disorders : official journal of the Movement Disorder Society', 'International journal of molecular sciences', 'PloS one', 'Biochimica et biophysica acta. Molecular cell research', 'PloS one', 'Current molecular medicine', 'Proceedings of the National Academy of Sciences of the United States of America', 'Archives of neurology', 'Somatic cell and molecular genetics', 'American journal of medical genetics. Part A', 'NeuroImage. Clinical', 'Cells', 'Neuropsychologia', 'Ophthalmology. Glaucoma', 'Chemosphere', 'Brain research bulletin', 'Journal of neuroscience research', 'Neurobiology of aging', "Journal of Alzheimer's disease : JAD", 'Amyotrophic lateral sclerosis & frontotemporal degeneration', 'Human molecular genetics', 'The Journal of neuroscience : the official journal of the Society for Neuroscience', 'Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia', 'Spine', 'Aging cell', 'The International journal of neuroscience', 'Scientific reports', 'Annals of palliative medicine', 'Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association', 'Scientific reports', 'Neurobiology of disease', 'The Journal of thoracic and cardiovascular surgery', 'Trials', 'Molecular neurobiology', 'Arquivos de neuro-psiquiatria', 'Journal of cell science', 'Movement disorders : official journal of the Movement Disorder Society', 'Cortex; a journal devoted to the study of the nervous system and behavior', 'Journal of neuropathology and experimental neurology', 'Cochlear implants international', 'Aging clinical and experimental research', 'Continuum (Minneapolis, Minn.)', 'mAbs', 'Cerebrovascular diseases (Basel, Switzerland)', 'Sleep & breathing = Schlaf & Atmung', "Alzheimer's & dementia : the journal of the Alzheimer's Association", 'Cell biology and toxicology', 'Journal of magnetic resonance imaging : JMRI', 'Progress in retinal and eye research', 'Biomolecules', 'ACS chemical neuroscience', 'Biochimica et biophysica acta. Molecular basis of disease', 'Journal of biomedical science', 'Translational psychiatry', "Journal of Alzheimer's disease : JAD", 'Nature communications', 'Human molecular genetics', 'Disability and rehabilitation', 'Neuroscience letters', 'Neurotoxicity research', 'Progress in neurobiology', 'Journal of hand therapy : official journal of the American Society of Hand Therapists', 'Biochemical and biophysical research communications', 'Asia-Pacific journal of public health', 'Environmental health perspectives', 'Histology and histopathology', 'CNS & neurological disorders drug targets', 'The lancet. Healthy longevity', 'Nutrients', "Journal of Alzheimer's disease : JAD", 'Neurologia', 'Brain : a journal of neurology', 'Scientific reports', 'Brain : a journal of neurology', 'Human molecular genetics', 'Human molecular genetics', 'The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases', 'Oncotarget', 'Behavioural brain research', 'PloS one', 'Radiation and environmental biophysics', 'Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics', 'Current opinion in biotechnology', 'CNS drugs', 'ASN neuro', 'BMC neurology', 'JNMA; journal of the Nepal Medical Association', 'Scientific reports', 'CNS & neurological disorders drug targets', 'Trends in pharmacological sciences', 'Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference', 'Journal of clinical and experimental neuropsychology', 'Scientific reports', 'Cell transplantation', 'Medicinal chemistry (Shariqah (United Arab Emirates))', 'Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology', 'BMC bioinformatics', 'Journal of tissue engineering and regenerative medicine', 'Journal of long-term effects of medical implants', 'Proteomics. Clinical applications', 'Current gene therapy', 'Neuroscience letters', 'Human molecular genetics', 'Current cardiology reviews', 'Nutritional neuroscience', 'Medical hypotheses', 'Advances in experimental medicine and biology', 'Journal of neurology', 'Biological psychiatry. Cognitive neuroscience and neuroimaging', 'Orphanet journal of rare diseases', 'International journal of molecular sciences', 'Pharmacological research', 'The Lancet. Neurology', 'Human molecular genetics', 'Current pharmaceutical biotechnology', 'European journal of medical genetics', 'Molecular neurodegeneration', 'Molecular neurodegeneration', 'Proceedings of the National Academy of Sciences of the United States of America', 'Human molecular genetics', 'Toxicology', 'PLoS genetics', 'Glia', 'Expert opinion on investigational drugs', 'Rejuvenation research', 'Orphanet journal of rare diseases', 'Clinical and experimental obstetrics & gynecology', 'Preventive medicine', 'Lipids', "Bailliere's clinical rheumatology", 'Nature aging', 'Sensors (Basel, Switzerland)', 'Oncogene', 'Advances in experimental medicine and biology', 'Nature communications', 'Nature', 'PLoS genetics', 'PLoS genetics', 'PLoS genetics', 'Cell transplantation', 'Cellular and molecular life sciences : CMLS', "Journal of Alzheimer's disease : JAD", "Journal of Alzheimer's disease : JAD", 'EMBO molecular medicine', 'Experimental neurology', 'Molecular neurobiology', "Annali dell'Istituto superiore di sanita", 'Rheumatology (Oxford, England)', 'Advances in experimental medicine and biology', 'Ear and hearing', 'Sensors (Basel, Switzerland)', 'Technology in cancer research & treatment', "Journal of Alzheimer's disease : JAD", "The journal of prevention of Alzheimer's disease", 'Ageing research reviews', 'Experimental neurology', 'Alcohol research & health : the journal of the National Institute on Alcohol Abuse and Alcoholism', 'Pacing and clinical electrophysiology : PACE', 'Surgical technology international', 'BioFactors (Oxford, England)', 'Cytotherapy', 'BioEssays : news and reviews in molecular, cellular and developmental biology', 'The Journal of prosthetic dentistry', 'Current biology : CB', 'Brain : a journal of neurology', 'The West Virginia medical journal', 'Journal of neuromuscular diseases', 'Cells', 'Current medical imaging', 'Journal of the American Nutrition Association', 'Molecular psychiatry', 'Journal of medical genetics', 'Orphanet journal of rare diseases', "Journal of Alzheimer's disease : JAD", 'Human molecular genetics', 'Brain : a journal of neurology', 'Metallomics : integrated biometal science', 'Diabetes technology & therapeutics', 'Jornal de pediatria', 'Neurochemical research', 'European journal of nuclear medicine and molecular imaging', 'Nature genetics', 'Frontiers in bioscience (Landmark edition)', 'Methods in molecular biology (Clifton, N.J.)', 'Brain research bulletin', 'Frontiers in cellular and infection microbiology', 'Clinical toxicology (Philadelphia, Pa.)', 'Molecular medicine reports', 'Biochemical pharmacology', 'Disease models & mechanisms', 'eNeuro', 'Disease models & mechanisms', 'PloS one', 'Health & social care in the community', 'PLoS genetics', 'The Journal of biological chemistry', 'Spinal cord', 'Journal of the neurological sciences', 'Journal of neurotrauma', 'Annals of nuclear medicine', 'Journal of the neurological sciences', 'Proceedings of the National Academy of Sciences of the United States of America', 'The New England journal of medicine', 'Current medicinal chemistry', 'Seminars in pediatric neurology', 'Translational neurodegeneration', 'Current neuropharmacology', "Alzheimer's & dementia : the journal of the Alzheimer's Association", 'Military medicine', 'Neurosurgical review', 'Human molecular genetics', 'Photodermatology, photoimmunology & photomedicine', 'Pharmacology & therapeutics', 'PLoS genetics', 'Mechanisms of ageing and development', 'The Journal of neuroscience : the official journal of the Society for Neuroscience', 'Current drug targets. CNS and neurological disorders', 'Southern medical journal', 'Clinical pharmacology and therapeutics', 'NeuroImage. Clinical', 'Archives of biochemistry and biophysics', 'European journal of medicinal chemistry', 'Molecular neurobiology', 'Human molecular genetics', 'Oxidative medicine and cellular longevity', 'Neurobiology of disease', 'Brain connectivity', 'Hippocampus', 'Nucleic acids research', 'Human molecular genetics', 'International journal of molecular sciences', 'Cells', 'The journal of nutrition, health & aging', 'GeroScience', 'Physiology & behavior', 'Medicinal research reviews', 'Expert review of neurotherapeutics', 'Journal of translational medicine', 'Lancet (London, England)', 'The Journal of clinical investigation', 'American journal of medical genetics. Part C, Seminars in medical genetics', 'The Journal of neuroscience : the official journal of the Society for Neuroscience', 'Human molecular genetics', 'CNS neuroscience & therapeutics', 'Human molecular genetics', 'Archives of disease in childhood', 'The EMBO journal', 'Biological psychiatry', 'Amyotrophic lateral sclerosis and other motor neuron disorders : official publication of the World Federation of Neurology, Research Group on Motor Neuron Diseases', 'Autoimmunity reviews', "Journal of Alzheimer's disease : JAD", 'International psychogeriatrics', 'Journal of neurosurgical sciences', 'Journal of neuroscience methods', 'Autophagy', 'Reviews in the neurosciences', 'Journal of biomechanics', 'PM & R : the journal of injury, function, and rehabilitation', 'Comptes rendus biologies', 'Human molecular genetics', 'Neurobiology of aging', 'Archives of medical research', 'Cytotherapy', 'PLoS genetics', 'Brain : a journal of neurology', 'CNS & neurological disorders drug targets', 'The Journal of neuroscience : the official journal of the Society for Neuroscience', 'Advances in neurology', 'The Journal of neuroscience : the official journal of the Society for Neuroscience', 'Human molecular genetics', 'Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology', 'Current pharmaceutical design', 'Current medicinal chemistry', 'Antioxidants & redox signaling', 'Artificial intelligence in medicine', 'ACS chemical neuroscience', 'Acta myologica : myopathies and cardiomyopathies : official journal of the Mediterranean Society of Myology', 'International journal of biological sciences', 'Neuropharmacology', 'PloS one', 'Archives of pharmacal research', 'Disease models & mechanisms', 'Public health nutrition', 'The spine journal : official journal of the North American Spine Society', 'Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology', 'FASEB journal : official publication of the Federation of American Societies for Experimental Biology', 'Trends in endocrinology and metabolism: TEM', 'Pediatric neurology', 'NeuroImage', 'BMC musculoskeletal disorders', 'Journal of neuropathology and experimental neurology', "Alzheimer's research & therapy", 'Anais da Academia Brasileira de Ciencias', 'Molecules (Basel, Switzerland)', 'Environmental science & technology', "The journal of prevention of Alzheimer's disease", 'Molecules and cells', 'International journal of biological macromolecules', 'Neuroscience and biobehavioral reviews', 'Bone', 'The Journal of neuroscience : the official journal of the Society for Neuroscience', 'Ageing research reviews', 'Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology', 'Ageing research reviews', 'Journal of psychosomatic research', 'Neuron', 'Ageing research reviews', 'Disease models & mechanisms', "Journal of Alzheimer's disease : JAD", 'Expert opinion on drug metabolism & toxicology', 'Journal of nuclear medicine technology', 'GeroScience', 'Seminars in cell & developmental biology', 'Gerontology', 'IEEE transactions on medical imaging', 'Handbook of experimental pharmacology', "Alzheimer's research & therapy", 'Cells', 'Cellular signalling', 'Age and ageing', 'Ciencia & saude coletiva', 'Nutrients', 'Redox biology', 'JAMA network open', 'Scientific reports', 'International journal of molecular sciences', 'Age and ageing', 'Neurobiology of aging', 'International journal of molecular sciences', 'International journal of molecular sciences', 'Journal of neuroinflammation', 'Journal of agricultural and food chemistry', 'Proceedings of the National Academy of Sciences of the United States of America', 'Neurobiology of disease', 'Psychiatria Danubina', 'Biochemical and biophysical research communications', 'Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics', 'American journal of veterinary research', 'Ageing research reviews', 'Molecular neurobiology', 'Molecular neurodegeneration', 'Movement disorders : official journal of the Movement Disorder Society', 'HLA', 'Science China. Life sciences', 'The journals of gerontology. Series B, Psychological sciences and social sciences', 'Journal of biomolecular structure & dynamics', 'Studies in health technology and informatics', 'Biochemical pharmacology', 'International journal of molecular sciences', 'Translational neurodegeneration', 'Nature communications', 'Nutrients', 'Acta neuropathologica communications', 'Frontiers in endocrinology', 'Scientific reports', "American journal of Alzheimer's disease and other dementias", 'Chemistry & biodiversity', 'Aging cell', 'Geriatrics & gerontology international', 'Brain research', "Journal of Alzheimer's disease : JAD", 'The journals of gerontology. Series A, Biological sciences and medical sciences', "Journal of Alzheimer's disease : JAD", 'Aging cell', 'Journal of oral rehabilitation', 'Aging cell', 'Ageing research reviews', 'Advances in nutrition (Bethesda, Md.)', 'Advances in nutrition (Bethesda, Md.)', 'FEBS letters', 'Current stem cell research & therapy', 'Current molecular medicine', 'Frontiers in immunology', 'Alzheimer disease and associated disorders', "Alzheimer's research & therapy", 'Nature communications', 'Nature communications', 'Aging clinical and experimental research', 'Journal of the American Medical Directors Association', 'The journals of gerontology. Series A, Biological sciences and medical sciences', 'Molecular neurobiology', 'The journals of gerontology. Series A, Biological sciences and medical sciences', 'The FEBS journal', 'Proteomics', 'Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al]', 'Advanced biology']
TA: ['J Ovarian Res', 'Eur Rev Med Pharmacol Sci', 'OMICS', 'J Phys Chem B', 'Front Immunol', 'Nutrients', 'Medicina (Kaunas)', 'Cells', 'Neurol Neurochir Pol', 'Acta Neuropathol Commun', 'Int Immunopharmacol', 'Sci Rep', 'Mol Cell', 'Acta Biochim Pol', 'Molecules', 'Nutrients', 'Int J Mol Sci', 'Int J Mol Sci', 'Int J Mol Sci', 'Continuum (Minneap Minn)', 'IEEE Trans Neural Syst Rehabil Eng', 'J Mater Chem B', 'Adv Clin Chem', 'J Nucl Med', 'J Nucl Med', 'Metabolism', 'Cells', 'Sci Data', 'Exp Eye Res', 'PLoS One', 'Bioengineered', 'Elife', 'Cell Immunol', 'Open Vet J', 'Biomed Pharmacother', 'JAMA Psychiatry', 'BMC Psychiatry', 'Neurosci Res', 'Neurobiol Dis', 'Nutrients', 'Int J Mol Sci', 'Fluids Barriers CNS', 'Int J Biol Macromol', 'J Alzheimers Dis', 'Rev Neurol (Paris)', 'Ageing Res Rev', 'J Mol Neurosci', 'JAMA Netw Open', 'Adv Mind Body Med', 'Geroscience', 'Molecules', 'Nutrients', 'Int J Mol Sci', 'Int J Mol Sci', 'Alzheimers Res Ther', 'Gene', 'OMICS', 'Geroscience', 'Sci Rep', 'JAMA Neurol', 'Sci Adv', 'Chem Biol Drug Des', 'J Appl Physiol (1985)', 'Nucleic Acids Res', 'Oxid Med Cell Longev', 'BMJ', 'Neurology', 'J Neuroinflammation', 'Hum Brain Mapp', 'Acta Neuropathol Commun', 'Stem Cell Res Ther', 'Int J Environ Res Public Health', 'Int J Mol Sci', 'Molecules', 'Neurobiol Dis', 'Neurobiol Dis', 'Neuroimage Clin', 'Transl Neurodegener', 'Neuroimage', 'Redox Biol', 'Nat Neurosci', 'Brain', 'JAMA Neurol', 'Bioorg Chem', 'Metab Brain Dis', 'Aging Cell', 'Physiol Rev', 'Lancet Digit Health', 'Mitochondrion', 'Nutrients', 'Int J Environ Res Public Health', 'Int J Mol Sci', 'Genes (Basel)', 'Cells', 'Neurobiol Aging', 'Expert Rev Neurother', 'Fluids Barriers CNS', 'J Alzheimers Dis', 'Yi Chuan', 'J Neural Transm (Vienna)', 'Eur J Pharmacol', 'Neurotox Res', 'Neurotherapeutics', 'Ann Neurol', 'Free Radic Biol Med', 'Neurobiol Aging', 'Exp Gerontol', 'Nutrients', 'Parkinsonism Relat Disord', 'Sensors (Basel)', 'Int J Mol Sci', 'Int J Mol Sci', 'Cells', 'JAMA Psychiatry', 'Pharmacol Res', 'Mol Neurodegener', 'Neurobiol Aging', 'Geriatr Gerontol Int', 'Biofactors', 'Exp Gerontol', 'Int J Mol Sci', 'Nutrients', 'Nutrients', 'Sensors (Basel)', 'J Alzheimers Dis', 'Cells', 'Front Cell Infect Microbiol', 'Theranostics', 'Am J Physiol Cell Physiol', 'Acta Neuropathol', 'Alzheimers Res Ther', 'Top Antivir Med', 'J Biomed Sci', 'Neuroimage Clin', 'J Nutr Health Aging', 'Nat Rev Rheumatol', 'Molecules', 'Int J Mol Sci', 'Int J Mol Sci', 'Cells', 'EBioMedicine', 'J Neurovirol', 'Clinics (Sao Paulo)', 'Environ Res', 'Exp Gerontol', 'J Clin Exp Neuropsychol', 'Bone', 'Br J Radiol', 'J Neuroinflammation', 'Colloids Surf B Biointerfaces', 'J Neurosci', 'Neurotherapeutics', 'Neuropharmacology', 'Neural Plast', 'Oxid Med Cell Longev', 'FEBS Open Bio', 'Neuroimage', 'Lancet Neurol', 'Sci Data', 'Nutrients', 'Cells', 'Genes (Basel)', 'Curr Alzheimer Res', 'Cell Mol Life Sci', 'Proc Natl Acad Sci U S A', 'Cell Mol Life Sci', 'Mech Ageing Dev', 'Exp Gerontol', 'Neurosurgery', 'Adv Exp Med Biol', 'BMC Geriatr', 'Am J Clin Nutr', 'Transpl Immunol', 'Molecules', 'Nutrients', 'Mol Neurobiol', 'Biol Psychiatry', 'Neuroimage', 'J Integr Neurosci', 'Alzheimers Res Ther', 'Neuroimage', 'Naunyn Schmiedebergs Arch Pharmacol', 'J Affect Disord', 'Neurobiol Dis', 'Life Sci', 'Curr Neuropharmacol', 'Biosens Bioelectron', 'Nutrients', 'Eur J Med Chem', 'Prog Neurobiol', 'Oxid Med Cell Longev', 'Biomolecules', 'Cells', 'Cells', 'Cells', 'Environ Health Perspect', 'Food Funct', 'J Food Biochem', 'J Huntingtons Dis', 'Proc Inst Mech Eng H', 'Ageing Res Rev', 'Geroscience', 'J Pharm Biomed Anal', 'Exp Gerontol', 'Alzheimers Res Ther', 'Curr Alzheimer Res', 'Alzheimers Res Ther', 'Front Public Health', 'J Alzheimers Dis', 'Aging Cell', 'Mutat Res Rev Mutat Res', 'Annu Int Conf IEEE Eng Med Biol Soc', 'Biochimie', 'Pac Symp Biocomput', 'Curr Opin Lipidol', 'ScientificWorldJournal', 'Int J Mol Sci', 'J Neurosci Res', 'Curr Alzheimer Res', 'Mol Neurodegener', 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'Clin Infect Dis', 'Nutr Neurosci', 'Pract Neurol', 'Hum Mol Genet', 'J Clin Neurosci', 'Behav Neurol', 'Brain', 'Proc Natl Acad Sci U S A', 'Hum Mol Genet', 'Curr Top Med Chem', 'Hum Mol Genet', 'J Neurochem', 'Nat Rev Drug Discov', 'Proc Natl Acad Sci U S A', 'NeuroRehabilitation', 'Ann Surg', 'Int J Mol Sci', 'Gac Med Mex', 'IEEE/ACM Trans Comput Biol Bioinform', 'Curr Opin Pulm Med', 'Plant Foods Hum Nutr', 'Medicina (Kaunas)', 'Epilepsy Behav', 'Curr Med Chem', 'J Neurol Sci', 'J Alzheimers Dis', 'Oncotarget', 'Ann Pharm Fr', 'PLoS Comput Biol', 'Pediatr Res', 'Neuroscience', 'Clin Orthop Relat Res', 'Urol Clin North Am', 'J Neurol', 'J Prev Alzheimers Dis', 'J Alzheimers Dis', 'J Alzheimers Dis', 'J Int Neuropsychol Soc', 'Neurosci Biobehav Rev', 'Br J Pharmacol', 'Rev Neurosci', 'Neuroimage Clin', 'Hum Mol Genet', 'Sci Rep', 'J Biol Chem', 'Psychiatr Danub', 'J Environ Monit', 'Pediatr Res', 'Nat Clin Pract Neurol', 'Rev Neurosci', 'Hum Mol Genet', 'Horm Res', 'J Palliat Care', 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'Clin Immunol', 'J Endocrinol Invest', 'Proc Natl Acad Sci U S A', 'Proc Natl Acad Sci U S A', 'Brain', 'Klin Monbl Augenheilkd', 'Prog Growth Factor Res', 'Curr Med Chem', 'PLoS One', 'J Neurovirol', 'Front Neuroendocrinol', 'Expert Opin Ther Pat', 'Curr Top Dev Biol', 'Hum Mol Genet', 'CNS Neurol Disord Drug Targets', 'J Biol Chem', 'Rev Neurosci', 'Can J Public Health', 'Curr Pharm Des', 'Curr Pharm Des', 'Disabil Rehabil', 'PLoS Med', 'Int J Mol Sci', 'Acta Neuropathol Commun', 'Mov Disord', 'Int J Mol Sci', 'PLoS One', 'Biochim Biophys Acta Mol Cell Res', 'PLoS One', 'Curr Mol Med', 'Proc Natl Acad Sci U S A', 'Arch Neurol', 'Somat Cell Mol Genet', 'Am J Med Genet A', 'Neuroimage Clin', 'Cells', 'Neuropsychologia', 'Ophthalmol Glaucoma', 'Chemosphere', 'Brain Res Bull', 'J Neurosci Res', 'Neurobiol Aging', 'J Alzheimers Dis', 'Amyotroph Lateral Scler Frontotemporal Degener', 'Hum Mol Genet', 'J Neurosci', 'J Clin Neurosci', 'Spine (Phila Pa 1976)', 'Aging Cell', 'Int J Neurosci', 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Brain Res', 'PLoS One', 'Radiat Environ Biophys', 'Neurotherapeutics', 'Curr Opin Biotechnol', 'CNS Drugs', 'ASN Neuro', 'BMC Neurol', 'JNMA J Nepal Med Assoc', 'Sci Rep', 'CNS Neurol Disord Drug Targets', 'Trends Pharmacol Sci', 'Annu Int Conf IEEE Eng Med Biol Soc', 'J Clin Exp Neuropsychol', 'Sci Rep', 'Cell Transplant', 'Med Chem', 'J Neuroimmune Pharmacol', 'BMC Bioinformatics', 'J Tissue Eng Regen Med', 'J Long Term Eff Med Implants', 'Proteomics Clin Appl', 'Curr Gene Ther', 'Neurosci Lett', 'Hum Mol Genet', 'Curr Cardiol Rev', 'Nutr Neurosci', 'Med Hypotheses', 'Adv Exp Med Biol', 'J Neurol', 'Biol Psychiatry Cogn Neurosci Neuroimaging', 'Orphanet J Rare Dis', 'Int J Mol Sci', 'Pharmacol Res', 'Lancet Neurol', 'Hum Mol Genet', 'Curr Pharm Biotechnol', 'Eur J Med Genet', 'Mol Neurodegener', 'Mol Neurodegener', 'Proc Natl Acad Sci U S A', 'Hum Mol Genet', 'Toxicology', 'PLoS Genet', 'Glia', 'Expert Opin Investig Drugs', 'Rejuvenation Res', 'Orphanet J Rare Dis', 'Clin Exp Obstet 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Behav', 'Med Res Rev', 'Expert Rev Neurother', 'J Transl Med', 'Lancet', 'J Clin Invest', 'Am J Med Genet C Semin Med Genet', 'J Neurosci', 'Hum Mol Genet', 'CNS Neurosci Ther', 'Hum Mol Genet', 'Arch Dis Child', 'EMBO J', 'Biol Psychiatry', 'Amyotroph Lateral Scler Other Motor Neuron Disord', 'Autoimmun Rev', 'J Alzheimers Dis', 'Int Psychogeriatr', 'J Neurosurg Sci', 'J Neurosci Methods', 'Autophagy', 'Rev Neurosci', 'J Biomech', 'PM R', 'C R Biol', 'Hum Mol Genet', 'Neurobiol Aging', 'Arch Med Res', 'Cytotherapy', 'PLoS Genet', 'Brain', 'CNS Neurol Disord Drug Targets', 'J Neurosci', 'Adv Neurol', 'J Neurosci', 'Hum Mol Genet', 'Gynecol Endocrinol', 'Curr Pharm Des', 'Curr Med Chem', 'Antioxid Redox Signal', 'Artif Intell Med', 'ACS Chem Neurosci', 'Acta Myol', 'Int J Biol Sci', 'Neuropharmacology', 'PLoS One', 'Arch Pharm Res', 'Dis Model Mech', 'Public Health Nutr', 'Spine J', 'Neuropsychopharmacology', 'FASEB J', 'Trends Endocrinol Metab', 'Pediatr Neurol', 'Neuroimage', 'BMC 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'Mov Disord', 'HLA', 'Sci China Life Sci', 'J Gerontol B Psychol Sci Soc Sci', 'J Biomol Struct Dyn', 'Stud Health Technol Inform', 'Biochem Pharmacol', 'Int J Mol Sci', 'Transl Neurodegener', 'Nat Commun', 'Nutrients', 'Acta Neuropathol Commun', 'Front Endocrinol (Lausanne)', 'Sci Rep', 'Am J Alzheimers Dis Other Demen', 'Chem Biodivers', 'Aging Cell', 'Geriatr Gerontol Int', 'Brain Res', 'J Alzheimers Dis', 'J Gerontol A Biol Sci Med Sci', 'J Alzheimers Dis', 'Aging Cell', 'J Oral Rehabil', 'Aging Cell', 'Ageing Res Rev', 'Adv Nutr', 'Adv Nutr', 'FEBS Lett', 'Curr Stem Cell Res Ther', 'Curr Mol Med', 'Front Immunol', 'Alzheimer Dis Assoc Disord', 'Alzheimers Res Ther', 'Nat Commun', 'Nat Commun', 'Aging Clin Exp Res', 'J Am Med Dir Assoc', 'J Gerontol A Biol Sci Med Sci', 'Mol Neurobiol', 'J Gerontol A Biol Sci Med Sci', 'FEBS J', 'Proteomics', 'Strahlenther Onkol', 'Adv Biol (Weinh)']
IF: [4.0, 3.3, 3.3, 3.3, 7.3, 5.9, 0.0, 6.0, 2.9, 7.1, 5.6, 0.0, 16.0, 1.7, 0.0, 5.9, 5.6, 5.6, 5.6, 0.0, 0.0, 7.0, 0.0, 9.3, 9.3, 9.8, 6.0, 9.8, 3.4, 3.7, 0.0, 7.7, 4.3, 1.2, 7.5, 25.8, 0.0, 2.9, 6.1, 5.9, 5.6, 7.3, 8.2, 4.0, 3.0, 13.1, 3.1, 13.8, 0.0, 5.6, 0.0, 5.9, 5.6, 5.6, 9.0, 3.5, 3.3, 5.6, 0.0, 29.0, 13.6, 3.0, 0.0, 14.9, 0.0, 0.0, 9.9, 9.3, 0.0, 7.1, 7.5, 0.0, 5.6, 0.0, 6.1, 6.1, 0.0, 12.6, 5.7, 11.4, 25.0, 14.5, 29.0, 0.0, 3.6, 7.8, 33.6, 30.8, 0.0, 5.9, 0.0, 5.6, 3.5, 6.0, 4.2, 4.3, 7.3, 4.0, 0.0, 0.0, 0.0, 3.7, 5.7, 11.2, 0.0, 4.2, 3.9, 5.9, 4.1, 0.0, 5.6, 5.6, 6.0, 25.8, 9.3, 15.1, 4.2, 3.3, 6.0, 3.9, 5.6, 5.9, 5.9, 0.0, 4.0, 6.0, 5.7, 12.4, 0.0, 12.7, 9.0, 0.0, 11.0, 0.0, 5.8, 33.7, 0.0, 5.6, 5.6, 6.0, 11.1, 3.2, 0.0, 8.3, 3.9, 2.2, 4.1, 0.0, 9.3, 0.0, 0.0, 5.7, 0.0, 3.1, 0.0, 2.6, 5.7, 48.0, 9.8, 5.9, 6.0, 3.5, 2.1, 8.0, 11.1, 8.0, 0.0, 3.9, 0.0, 0.0, 4.1, 7.1, 1.5, 0.0, 5.9, 0.0, 10.6, 5.7, 1.8, 9.0, 5.7, 0.0, 6.6, 6.1, 6.1, 0.0, 12.6, 5.9, 6.7, 6.7, 0.0, 5.5, 6.0, 6.0, 6.0, 10.4, 6.1, 4.0, 3.1, 0.0, 13.1, 5.6, 3.4, 3.9, 9.0, 2.1, 9.0, 0.0, 4.0, 7.8, 0.0, 0.0, 3.9, 0.0, 0.0, 0.0, 5.6, 4.2, 2.1, 15.1, 2.4, 0.0, 3.4, 0.0, 12.4, 2.7, 4.1, 3.6, 5.9, 5.6, 5.6, 5.5, 2.8, 5.7, 15.9, 3.1, 0.0, 2.9, 8.2, 3.9, 0.0, 2.4, 4.0, 3.6, 3.5, 0.0, 0.0, 3.0, 39.3, 2.7, 2.0, 15.1, 3.2, 13.1, 3.2, 0.0, 10.9, 2.8, 17.1, 5.7, 29.0, 4.2, 0.0, 8.0, 0.0, 8.3, 0.0, 0.0, 2.6, 3.6, 13.1, 19.6, 6.0, 6.0, 6.0, 6.0, 5.6, 5.5, 7.7, 8.0, 13.1, 6.7, 3.1, 0.0, 2.5, 0.0, 0.0, 7.1, 3.9, 6.4, 4.2, 12.4, 13.8, 4.0, 7.3, 7.3, 0.0, 0.0, 3.3, 7.8, 1.6, 4.3, 11.0, 0.0, 5.6, 6.0, 6.0, 14.0, 4.0, 0.0, 0.0, 13.1, 12.8, 0.0, 7.5, 3.8, 0.0, 4.0, 7.8, 0.0, 0.0, 4.0, 5.5, 5.6, 5.6, 5.6, 0.0, 0.0, 0.0, 0.0, 2.9, 0.0, 2.0, 0.0, 6.1, 0.0, 7.8, 6.1, 5.6, 5.6, 5.6, 3.6, 2.6, 11.1, 2.1, 6.8, 48.0, 3.6, 3.1, 0.0, 6.2, 13.1, 7.1, 7.9, 6.1, 3.7, 3.2, 0.0, 0.0, 5.9, 4.0, 5.6, 5.6, 5.6, 6.0, 5.5, 0.0, 2.0, 4.3, 2.9, 0.0, 1.7, 0.0, 13.1, 0.0, 0.0, 2.3, 4.3, 0.0, 3.7, 13.3, 0.0, 10.9, 0.0, 0.0, 0.0, 29.0, 14.0, 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IF5: [4.7, 3.1, 3.0, 3.0, 8.0, 6.6, 0.0, 6.7, 1.9, 7.8, 5.6, 0.0, 18.4, 2.0, 0.0, 6.6, 6.2, 6.2, 6.2, 0.0, 0.0, 6.5, 0.0, 9.0, 9.0, 9.9, 6.7, 10.8, 3.6, 3.8, 0.0, 8.3, 4.8, 1.3, 6.8, 24.0, 0.0, 2.9, 6.0, 6.6, 6.2, 7.5, 7.8, 4.9, 3.0, 14.5, 3.1, 13.0, 0.0, 5.7, 0.0, 6.6, 6.2, 6.2, 9.2, 3.3, 3.0, 5.7, 0.0, 22.2, 15.4, 2.7, 0.0, 16.4, 0.0, 0.0, 10.3, 9.8, 0.0, 7.8, 8.0, 0.0, 6.2, 0.0, 6.0, 6.0, 0.0, 10.9, 7.0, 11.9, 27.7, 14.6, 22.2, 0.0, 3.5, 9.2, 49.4, 30.9, 0.0, 6.6, 0.0, 6.2, 3.9, 6.7, 4.7, 4.4, 7.5, 4.9, 0.0, 0.0, 0.0, 3.6, 7.5, 11.4, 0.0, 4.7, 4.3, 6.6, 4.4, 0.0, 6.2, 6.2, 6.7, 24.0, 8.8, 15.8, 4.7, 3.3, 6.1, 4.3, 6.2, 6.6, 6.6, 0.0, 4.9, 6.7, 5.9, 12.3, 0.0, 16.2, 9.2, 0.0, 10.9, 0.0, 5.1, 29.1, 0.0, 6.2, 6.2, 6.7, 10.0, 2.8, 0.0, 8.2, 4.3, 2.5, 4.5, 0.0, 9.8, 0.0, 0.0, 7.5, 0.0, 4.1, 0.0, 2.5, 7.0, 51.3, 10.8, 6.6, 6.7, 3.9, 3.3, 8.7, 12.0, 8.7, 0.0, 4.3, 0.0, 0.0, 4.9, 7.8, 1.4, 0.0, 6.6, 0.0, 11.9, 7.0, 1.7, 9.2, 7.0, 0.0, 6.3, 6.0, 5.8, 0.0, 10.8, 6.6, 6.5, 10.2, 0.0, 5.8, 6.7, 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alias names:
description: Hereditary and sporadic conditions which are characterized by progressive nervous system dysfunction.
url: https://www.ncbi.nlm.nih.gov/mesh/68019636
mutation position:
mutation alleles:
MeSH ID: D019636
relation: True
external links: []
aging biomarker: False
longevity biomarker: False
The edge also has a
relationship, which specifies how the two nodes are related.
source and target attributes, which are alternative names for the entities and which we will not use.
source type and target type which refer to the type atribute of the source and target nodes.
A range of attributes related to the publications in which the relationship modelled by the edge is described (PMID, DP, TI,TA, IF, IF5).
A list of methods, which we will not use.
A deeper dive into the data#
Let’s do a deeper dive into the data now. We should easily be able to find out what the type of entity, the type of relation, and how many of each there are. This will require us to do a full pass through the data. The edges contain all of the information we need here so we can just iterate through those.
EntityTypes = set()
nodekeys = nodes.keys()
for k in nodekeys:
EntityTypes.add(nodes[k][0]['type'])
print("The entity types are:")
for i in EntityTypes:
print(i)
The entity types are:
Disease
Gene
Peptide
RNA
Pharmaceutical Preparations
Toxin
Mutation
Lipid
Carbohydrate
Protein
How many of each type are there?
EntityCount = dict.fromkeys(EntityTypes,0)
for k in nodekeys:
EntityCount[nodes[k][0]['type']] += 1
print("The entity counts are:")
for i in EntityTypes:
print(f"* {i}: {EntityCount[i]}")
The entity counts are:
* Disease: 3500
* Gene: 5623
* Peptide: 81
* RNA: 387
* Pharmaceutical Preparations: 14
* Toxin: 12
* Mutation: 2215
* Lipid: 176
* Carbohydrate: 210
* Protein: 28
Let’s now repeat for the edges:
RelationTypes = set()
edgekeys = edges.keys()
for k in edgekeys:
RelationTypes.add(edges[k]['relationship'])
#print("The entity types are:")
#for i in RelationTypes:
#print(i)
How many of each type of relation?
RelationCount = dict.fromkeys(RelationTypes,0)
for k in edgekeys:
RelationCount[edges[k]['relationship']] += 1
#print("The relation counts are:")
#for i in RelationTypes:
# print(f"* {i}: {RelationCount[i]}")
Plot some graphs of these
import matplotlib.pyplot as plt
plt.pie(EntityCount.values(), labels=EntityCount.keys())
plt.title('Number of each type of Entity')
Text(0.5, 1.0, 'Number of each type of Entity')
plt.pie(RelationCount.values(), labels=RelationCount.keys())
plt.title('Number of each type of Relation')
Text(0.5, 1.0, 'Number of each type of Relation')
Also interesting to look at the number of times each type of node is connected to each other type of node.
EntityEntityCounts = dict.fromkeys(EntityTypes,0)
for k in EntityEntityCounts.keys():
EntityEntityCounts[k] = dict.fromkeys(EntityTypes,0)
for k in edgekeys:
source = edges[k]['source type'][0]
target = edges[k]['target type'][0]
EntityEntityCounts[source][target] += 1
for k in EntityTypes:
print(EntityEntityCounts[k])
{'Disease': 80822, 'Gene': 6809, 'Peptide': 206, 'RNA': 71, 'Pharmaceutical Preparations': 12, 'Toxin': 7, 'Mutation': 455, 'Lipid': 1126, 'Carbohydrate': 1287, 'Protein': 170}
{'Disease': 12807, 'Gene': 4187, 'Peptide': 76, 'RNA': 50, 'Pharmaceutical Preparations': 1, 'Toxin': 0, 'Mutation': 273, 'Lipid': 317, 'Carbohydrate': 374, 'Protein': 50}
{'Disease': 375, 'Gene': 99, 'Peptide': 19, 'RNA': 0, 'Pharmaceutical Preparations': 0, 'Toxin': 0, 'Mutation': 1, 'Lipid': 12, 'Carbohydrate': 22, 'Protein': 0}
{'Disease': 200, 'Gene': 81, 'Peptide': 0, 'RNA': 7, 'Pharmaceutical Preparations': 0, 'Toxin': 0, 'Mutation': 4, 'Lipid': 3, 'Carbohydrate': 3, 'Protein': 0}
{'Disease': 21, 'Gene': 0, 'Peptide': 0, 'RNA': 0, 'Pharmaceutical Preparations': 0, 'Toxin': 0, 'Mutation': 0, 'Lipid': 0, 'Carbohydrate': 2, 'Protein': 0}
{'Disease': 4, 'Gene': 0, 'Peptide': 0, 'RNA': 0, 'Pharmaceutical Preparations': 0, 'Toxin': 2, 'Mutation': 0, 'Lipid': 0, 'Carbohydrate': 0, 'Protein': 0}
{'Disease': 634, 'Gene': 317, 'Peptide': 1, 'RNA': 1, 'Pharmaceutical Preparations': 0, 'Toxin': 0, 'Mutation': 165, 'Lipid': 17, 'Carbohydrate': 9, 'Protein': 0}
{'Disease': 1737, 'Gene': 248, 'Peptide': 10, 'RNA': 0, 'Pharmaceutical Preparations': 0, 'Toxin': 0, 'Mutation': 20, 'Lipid': 365, 'Carbohydrate': 98, 'Protein': 4}
{'Disease': 1788, 'Gene': 318, 'Peptide': 11, 'RNA': 1, 'Pharmaceutical Preparations': 0, 'Toxin': 0, 'Mutation': 8, 'Lipid': 82, 'Carbohydrate': 256, 'Protein': 9}
{'Disease': 265, 'Gene': 49, 'Peptide': 1, 'RNA': 0, 'Pharmaceutical Preparations': 0, 'Toxin': 0, 'Mutation': 0, 'Lipid': 3, 'Carbohydrate': 11, 'Protein': 4}
Creating the Ontology#
Now we are in a position to create the ontology. A major challenge here is that we need to do this dynamically. Our approach will be to store the classes in a dictionary from where they can still be called.
We will first create the entities.
from owlready2 import *
import types
onto = get_ontology("http://www.dummy.info/new.owl")
with onto:
EntityClass = dict.fromkeys(EntityTypes, None)
print(EntityClass)
for t in EntityTypes:
EntityClass[t] = types.new_class(t, (Thing,))
print(EntityClass[t])
print(EntityClass)
{'Disease': None, 'Gene': None, 'Peptide': None, 'RNA': None, 'Pharmaceutical Preparations': None, 'Toxin': None, 'Mutation': None, 'Lipid': None, 'Carbohydrate': None, 'Protein': None}
new.Disease
new.Gene
new.Peptide
new.RNA
new.Pharmaceutical Preparations
new.Toxin
new.Mutation
new.Lipid
new.Carbohydrate
new.Protein
{'Disease': new.Disease, 'Gene': new.Gene, 'Peptide': new.Peptide, 'RNA': new.RNA, 'Pharmaceutical Preparations': new.Pharmaceutical Preparations, 'Toxin': new.Toxin, 'Mutation': new.Mutation, 'Lipid': new.Lipid, 'Carbohydrate': new.Carbohydrate, 'Protein': new.Protein}
Now we create the relationships. For this, we need to determine the domain and range for each type of relation
RelationDomainRange = dict.fromkeys(RelationTypes,None)
for r in RelationTypes:
RelationDomainRange[r] = {'Domain':set(), 'Range':set()}
for k in edgekeys:
relationtype = edges[k]['relationship']
source = edges[k]['source type']
target = edges[k]['target type']
RelationDomainRange[relationtype]['Domain'].add(source[0])
RelationDomainRange[relationtype]['Range'].add(target[0])
#for r in RelationDomainRange.keys():
# print(f"{r}: {RelationDomainRange[r]}")
Now we have this, we can create the relations
Relations = dict.fromkeys(RelationTypes, None)
with onto:
for t in RelationTypes:
Relations[t] = types.new_class(t, (ObjectProperty,))
domain = list(RelationDomainRange[t]['Domain'])
range = list(RelationDomainRange[t]['Range'])
for d in domain:
Relations[t].domain.append(EntityClass[d])
for r in range:
Relations[t].range.append(EntityClass[r])
Check this this looks sensible against the ones printed out above
print(Relations['conceived'].domain)
print(Relations['noticed'].range)
[new.Disease, new.Gene, new.Disease, new.Gene]
[new.Disease, new.Gene, new.Disease, new.Gene]
Let’s now populate the graph. Start by adding the Entities
TheGraph = dict.fromkeys(nodekeys, None)
for n in nodekeys:
etype = nodes[n][0]['type']
TheGraph[n] = EntityClass[etype](name=n)
TheGraph[n].rel = []
Now the edges
TheGraph = dict.fromkeys(nodekeys, None)
for n in nodekeys:
nodetype = nodes[n][0]['type']
TheGraph[n] = EntityClass[nodetype](name=n)
TheGraph[n].rel = []
for k in edgekeys:
source = edges[k]['source entity']
target = edges[k]['target entity']
TheGraph[source].rel.append(TheGraph[target])
Get the edges for one node.
TheGraph['MLH1'].rel
[new.ARID1A,
new.Neoplasms,
new.Microsatellite Instability,
new.Death,
new.rs1800734,
new.rs749072,
new.rs13098279,
new.rs1800734,
new.rs749072,
new.rs13098279,
new.Colorectal Neoplasms,
new.Celiac Disease,
new.Neoplasms,
new.Hereditary Breast and Ovarian Cancer Syndrome]
Which nodes has the most connections from it? Which node has the most connections to it?
max_links = 0
for n in TheGraph.keys():
if len(TheGraph[n].rel)> max_links:
max_links = len(TheGraph[n].rel)
max_node = n
print(f"{max_node} has the most ({max_links}) outgoing links")
Death has the most (4741) outgoing links
IncomingLinks = dict.fromkeys(nodekeys,0)
for n in TheGraph.keys():
targets = TheGraph[n].rel
for t in targets:
IncomingLinks[t.name] += 1
print(f"{max(IncomingLinks, key=lambda k: IncomingLinks[k])} has the most incoming links ({max(IncomingLinks.values())})")
Death has the most incoming links (6020)